Kornimate/medical-research-clean huggingface dataset:
coagulation parameters in ibd patients

Conditions: Coagulopathy

Summary: 1. to assess the incidence of coagulation disorders in ibd patients in comparison with another normal controlled group 2. risk factors that contribute to development of thrombosis in ibd patients 3. to determine the effectiveness of prophlactive anticoagulant measures 4. to determine the association between disease activity and coagulation parameters

inflammatory bowel disease is a group of disorders associated with chronic, recurrent, and immune system-mediated inflammation of the bowel mucosa . the reported global incidence and prevalence rates for ulcerative colitis vary between 1.2-20.3 and 6-246 per 100000 persons, respectively, and the corresponding figures for crohns disease are 0.03-15.6 and 3.6-214 \[2 in a population based cohort study involving 1160 patients with ulcerative colitis, the complication-related mortality rate was 9.6% during follow-up period of 35 years, in another study, 221 patients with crohns disease were followed up for 33 years, with an overall complication-related mortality rate of of the extra-intestinal manifestations of inflammatory bowel disease (ibd), thromboembolic events represent a major cause of morbidity and mortality with a 3.6 times increased risk in comparison with the general population . although clinical observations suggest an incidence rate between 1 and 8% for thromboembolic events in subjects with ibd, postmortem studies point out to a much higher occurrence rate around 41% . as a matter of fact, these and similar findings have led to an increased interest in the search for the association between ibd and hypercoagulable states as a potential cause of increased morbidity and mortality due to thromboembolic events in ibd . for instance, the existence of documentable prothrombotic abnormalities and a positive history for thromboembolic complications were demonstrated in at least one third of the subjects with ibd in a study by solem et al inflammation and coagulation are two crucial systems that are in balance and constantly influence each other. the impact of inflammation on coagulation has been confirmed by several experimental studies showing that inflammatory mechanism shift the hemostatic balance to favor the activation of coagulation which, in turn, can also sustain inflammation promoting a vicious circle between chronic inflammation and thrombosis

Eligibility criteria:
inclusion criteria: all patients of ibd more than 18 years exclusion criteria: -all ibd patients less than 18 years-all diseases that cause coagulation disorders all diseases that cause coagulation disorders ( liver diseases , collagen diseases, other auto immune disease
statin effects on beta-amyloid and cerebral perfusion in adults at risk for alzheimer's disease

Conditions: Alzheimer's Disease

Summary: the purpose of the research is to see how simvastatin affects a substance in the body called beta-amyloid. beta-amyloid is found in the brain and in the liquid around the brain and spinal cord. high amounts of beta-amyloid may be associated with a greater risk of getting alzheimer's disease. this study will see if simvastatin can lower the amount of beta-amyloid in the spinal fluid. this study will also see if simvastatin affects memory and thinking, blood flow in the brain, and blood vessel function. the investigators hope that future studies show whether simvastatin might prevent memory loss and decrease the chance of developing alzheimer's disease.

studies show that some medicines that lower cholesterol may reduce the risk of developing alzheimer's disease, but this has not yet been proven in humans. we are looking for individuals to participate in this study to see if a cholesterol-lowering medication, called simvastatin affects blood flow to the brain, blood vessel function and a substance in the spinal fluid related to the changes in alzheimer's disease. the sharp study included 88 adults ages 40-72 with parental history of documented alzheimer's disease. the study had 9 visits over the course of 18 months. participants had fasting blood tests collected, completed a medical history questionnaire and medication side effect review, underwent lumbar puncture procedure, completed memory testing, and had ultrasound and mri procedures. participants were randomly assigned to receive either simvastatin or a placebo each night for 18 months.

Eligibility criteria:
inclusion criteria: * parent diagnosed with alzheimer's disease * age 40-72 exclusion criteria: * active liver disease * history of adverse reaction to statins * contraindication to lumbar puncture * elevated creatine kinase and creatinine lab values * use of medications known to interact with statins * history of dementia or mild cognitive impairment * currently pregnant or planning to become pregnant * use of large quantities of grapefruit juice (more than 1 quart per day) * contraindications to mri (for mri sub-study) * currently on cholesterol-lowering medication or use in past 4 months * history of heart attack, heart problems, stroke and/or diabetes * drinking more than a quart of grapefruit juice per day * metal implants, or metal debris in body (mri) * list of medications that interact with simvastatin
comparison of low-dose spiral breast ct with mri in major indications of mri for breast diagnostics

Conditions: Breast Cancer Diagnosis

Summary: comparison between two diagnostic modalities for breast cancer diagnosis. two different imaging systems are compared to evaluate the performance of the two systems

the diagnostic quality of mri of the breast has made this method a gold standard in the imaging of senologic lesions. low-dose dedicated breast ct (bct) with single photon-detection (nu:view, developed by ab-ct - advanced breast-ct gmbh) has emerged as a fully 3d imaging modality that uses ionizing radiation comparable to 2d mammography and has its intended use in helping with diagnosis in diagnostic breast imaging. the investigation is designed as a prospective non-randomized intra-individual cohort procedure comparison between the imaging platforms, nu:view and mri. across 3 hospital-based study sites in two countries, study participants (patients who meet study criteria and have consented) sequentially receive nu:view imaging and, with a delay of up to one week (preferably on the same day), mri imaging. at both times, patients receive contrast agent. images generated from breasts are evaluated by three independent radiologists and their scores and interpretations are statistically evaluated. the research aim is to demonstrate non-inferiority of bct compared with mri in major indications of mri for breast diagnostics. the perceived gain in the study is to generate data on clinical performance of the bct device nu:view and on the procedure that could be supportive of a tailored use of nu:view in patients with major indications of mri for breast diagnostics.

Eligibility criteria:
inclusion criteria: 1. sex: female 2. age: at least 18 years 3. inconclusive findings in conventional imaging or preoperative staging or evaluation of therapy response in the neoadjuvant chemotherapy setting or imaging of the breast after breast-conserving therapy or finding the cause of hemorrhagic nipple discharge or prosthesis imaging or screening of women with hereditary or familial increased risk for the development of breast cancer or axillary lymph node metastasis suspected to originate from breast tissue 4. persons able and willing to understand and sign informed consent form exclusion criteria: 1. known pregnancy or breastfeeding 2. presence of brca1 or brca2 allele 3. insufficient renal function (mdrd) 4. dysfunction of the thyroid gland (tsh degradation) 5. known allergy or intolerance against iodine-containing contrast enhancing agents or mri contrast enhancing agents 6. patients with paramagnetic or magnetic material inside the breast, claustrophobia

Keywords: breast ct
study examining the effect of exercise in people with rheumatoid arthritis taking anti-tnfalpha medication

Conditions: Arthritis, Rheumatoid

Summary: the purpose of this study is to determine whether exercise is beneficial for people with rheumatoid arthritis(ra) taking antitnfalpha medication

substantial progress has been made in the medical management of ra over the past decade but at present no drug therapy leads to long-term remission for all patients with ra. people may still continue to experience physical, psychological and functional consequences which could benefit from rehabilitation.little research exists on the effects of exercise for people with ra taking anti-tnfalpha therapy medication. it is proposed to conduct a randomized controlled trial to examine the effects of group exercise therapy in a gym setting or in a hydrotherapy pool compared to a control group.

Eligibility criteria:
inclusion criteria: * patients with ra receiving anti-tnfalpha therapy medication for more than three months * consenting male and female patients aged 18 - 70 years * patients will have a documented diagnosis of ra as classified by the american college of rheumatology (acr) criteria * acr functional class i, ii, iii exclusion criteria: * patients who have attended physiotherapy in the past three months * patients to whom exercise therapy or hydrotherapy are contraindicated * patients who have undergone joint surgery in the past six months

Keywords: arthritis, rheumatoid exercise biological therapy
musculoskeletal pain in long-term dizziness

Conditions: Vestibular Disease; Musculoskeletal Pain; Rehabilitation

Summary: this project is aimed at patients with dizziness believed to be due to conditions in the balance organ in the inner ear (vestibular diseases). dizziness can be bothersome and influence postural control negatively, and can cause secondary musculoskeletal disorders. dizziness can also result in reduced work capacity. the purpose of the project is to strengthen the knowledge base regarding symptom burden, prognosis and treatment of prolonged dizziness. the hypothesis is that musculoskeletal pain at baseline is a prognostic factor for prolonged dizziness.

patients referred to an tertiary otorhinolarynglogical clinic due to dizziness will be invited to participate in the study. the aims are to examine the prevalence, extent and distribution of musculoskeletal pain in patients with prolonged dizziness, and to investigate the associations between musculoskeletal pain, dizziness symptoms, psychological and physical function and health-related quality of life. furthermore, the aim is to monitor the natural course of the dizziness symptoms and functional status in these patients, and examine risk factors for prolonged disability after 6 and 12 months. the hypothesis is that muscle pain and distress at baseline may be independently associated with prolonged complaints at follow-up. finally, patients who still are dizzy and have pain after 12 months will be invited to participate in one of two group interventions a) modified vestibular rehabilitation and b) virtual reality / exergaming. the interventions will be feasibility studies with a pre-post design.

Eligibility criteria:
inclusion criteria: * patients referred to an otorhinolaryngological university clinic due to suspected vestibular disorders (dizziness) * patients must be bothered with dizziness at the time of consultation exclusion criteria: * patients uable to fill in questionnaires due language barriers * patients not able to undergo diagnostic and testing procedures * patients with vestibular schwannoma * patients with diving-related inner ear injuries

Keywords: vestibular disease musculoskeletal pain prognosis vestibular rehabilitation
effectiveness if premedication with single dose piroxicam and prednisolone after a single visit root canal treatment .

Conditions: Post-operative Endodontic Pain

Summary: two drugs (piroxicam and prednisolone)are being compared for post operative endodontic pain after a single visit root canal treatment for 74 hours.

to evaluate effectiveness of single dose premedication with piroxicam(20mg) and prednisolone(20mg) on post endodontic pain after a single visit root canal treatment . patient will be recalled every day for 4 days to know the pain scale using visual analogue scale .

Eligibility criteria:
inclusion criteria: 1. patient ages from 20-40 years(28). 2. single rooted tooth with symptomatic irreversible pulpitis. 3. with no analgesic or anti-inflammatory drug taken within a week period before procedure. exclusion criteria: 1. patients presenting with any systemic disease 2. patients already taking premedication for endodontic pain. 3. pregnant or lactating patients. 4. multirooted teeth. 5. teeth with pulpal necrosis. 6. previously treated or initiated root canal treatment. 7. patient presenting with allergy due to drug
study of bc3402 in combination with azacitidine in patients with mds and cmml

Conditions: Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia

Summary: the study is to evaluate safety, pharmacokinetics, pharmacodynamics and efficacy of bc3402 in combination with azacitidine (aza) in subjects with myelodysplastic syndrome (mds) and chronic myelomonocytic leukemia (cmml)


Eligibility criteria:
inclusion criteria: 1. mds and cmml subjects with higher risk; 2. age ≥ 18 years old; 3. eastern cooperative oncology group score of 0\~2; 4. not suitable for or refuse to receive hematopoietic stem cell transplant(hsct); 5. subjects should take effective contraceptive measures 6. must sign the informed consent form (icf), and be able to follow all study procedures. exclusion criteria: 1. prior exposure to anti-tim-3 therapy at any time 2. previous hsct 3. live vaccine administered within 4 weeks prior to start of treatment 4. current use or use within 7 days prior to start of treatment of systemic steroid therapy (\> 10 mg/day prednisone or equivalent) or any immunosuppressive therapy. topical, inhaled, nasal, ophthalmic steroids are allowed. other protocol-defined inclusion/exclusion may apply.
caretaker vs. blood pressure monitoring with invasive arterial pressure monitoring in patients with septic shock

Conditions: Blood Pressure

Summary: caretaker vs. blood pressure monitoring with invasive arterial pressure monitoring in patients with septic shock

the aim of this study is to compare blood pressure obtained using routine blood pressure sphygmomanometer, in patients with invasive arterial pressure monitoring that have septic shock, to a non-invasive device that continuously monitors central blood pressure (caretaker).

Eligibility criteria:
inclusion criteria: * admitted with septic shock, with or without vasopressor support needed. * greater than or equal to 18 years of age. * have an arterial catheter already in place. exclusion criteria: * no arterial catheter in place. * contraindication to the application of the caretaker device due to pre-existing finger injury. * patients in whom use of a bp cuff is contraindicated.
an assessment of goal-directed intraoperative fluid management in hand assisted laparoscopic colectomy

Conditions: Crohn's Disease; Ulcerative Colitis; Rectal Cancer; Colon Cancer; Colon Polyps; Rectal Polyps; Diverticulitis

Summary: the purpose of this study is to find out if guided fluid administration with the esophageal monitor is superior to standard fluid administration and whether use of the hetastarch or lactated ringers offers different benefits with respect to length of stay in the hospital after hand-assisted colorectal surgery.


Eligibility criteria:
inclusion criteria: 1. diagnoses of crohn's disease, ulcerative colitis, rectal or colon cancer, colon or rectal polyps and chronic or subacute diverticulitis 2. subjects who will undergo hand-assisted laparoscopic colectomy for benign or malignant pathology exclusion criteria: 1. patients requiring stoma formation as part of the operative procedure 2. patients undergoing loop ileostomy or colostomy closure thru the stomal site 3. bowel obstruction, coagulopathy, significant renal or hepatic dysfunction (creatinine \>1.6 or liver enzymes \> 50% upper limit of normal values) 4. congestive heart failure, unstable angina, or valvular heart disease with new york heart classification \>2

Keywords: hand-assisted colorectal surgery colorectal disease crohn's diverticulitis colorectal resections
anesthesia for emergency orthopedic surgery

Conditions: Anesthesia

Summary: the aim of this retrospective study is to evaluate the preferred anaesthesia techniques in our clinic for emergency orthopedic surgery at a 1 year period.

this retrospective study included patients of all ages who have undergone emergency orthopedic surgery between january 2015 and december 2015 after approval of the research ethics committee. medical record forms and electronic medical record system of the hospital were used in the analysis of medical data with regard to age, sex, asa score, anaesthesia technique, comorbidities, surgery diagnosis, length of surgery, complications and admission to intensive care unit after surgery.

Eligibility criteria:
inclusion criteria: * all patients who had orthopedic emergency surgery exclusion criteria: * involvement of incomplete data collection

Keywords: emergency orthopedic surgery anesthesia general anesthesia regional anesthesia
artificial intelligence delivered cardiac magnetic resonance - prospective validation

Conditions: Cardiovascular Diseases; Healthy Volunteers

Summary: cardiac mri (cmr) scanning allows doctors to create detailed images of the heart. however, the need for experienced cardiac radiographers to perform each scan can make cmr's delivery difficult, and some patients in the uk wait more than half a year for a scan. these radiographers must take pictures of different part of the heart, termed "views", each of which must be precisely positioned. the investigators believe they can revolutionise cmr, by using artificial intelligence to automatically position the views so radiographers can focus on more difficult tasks. the investigators have used a retrospective database of pseudonymised (anonymised and linked) cmr scans at our hospital to create these artificial intelligence (ai) algorithms, and they have validated them retrospectively on previous studies. the investigators now wish to test the algorithms prospectively. in this study, the investigators will recruit patients undergoing clinical cmr scans. in addition to the routine images acquired by expert radiographers, the investigators will require a duplicate set of images, positioned and planned by the ai algorithms. the investigators will then compare, within each patient, the ai-planned and expert-radiographer-planned scanning in terms of both speed and image quality.


Eligibility criteria:
inclusion criteria: * adult (aged at least 18 years) exclusion criteria: * children (patients below age 18). * pregnant patients.
trial of vitamin d3 supplementation in paediatric autism

Conditions: Autism

Summary: to build on a recent case study and open label trial, the investigators want to find out if vitamin d supplementation can influence behavioural and core symptoms of autism.

the investigators will assess behavioural and core symptoms of autism before and after 20 weeks of vitamin d supplementation in a double-blind, placebo-controlled trial.

Eligibility criteria:
inclusion criteria: * positive autism diagnostic observation schedule * stable medication regimen * tolerate phlebotomy exclusion criteria: * unstable or very severe autism * epilepsy * renal/liver/gastrointestinal disease
qdot based pvi for atrial fibrillation treatment - the peqasus study

Conditions: Atrial Fibrillation

Summary: peqasus is a worldwide, retrospective, multicenter analysis focusing on qdot based pvi. data of at least 300 patients with qdot based pvi will be collected. all data will be evaluated after anonymization. primary endoints are efficacy and safety.


Eligibility criteria:
inclusion criteria: * suitable for pvi exclusion criteria: * non suitable for pvi

Keywords: catheter abaltion, very high-power short-duration, qdot
dna methylation and lung disease in cystic fibrosis

Conditions: Cystic Fibrosis

Summary: lung disease progression is variable among cystic fibrosis (cf) patients and depends on dna mutations in the cftr gene, polymorphic variations in disease-modifier genes and environmental exposure. the contribution of genetic factors has been extensively investigated, whereas the mechanism whereby environmental factors modulate the lung disease is unknown. because these factors can affect the epigenome, investigators hypothesized that dna methylation variations at disease-modifier genes modulate the lung function in cf patients.

lung disease progression is variable among cystic fibrosis (cf) patients and depends on dna mutations in the cftr gene, polymorphic variations in disease-modifier genes and environmental exposure. the contribution of genetic factors has been extensively investigated, whereas the mechanism whereby environmental factors modulate the lung disease is unknown. because these factors can affect the epigenome, investigators hypothesized that dna methylation variations at disease-modifier genes modulate the lung function in cf patients. the investigators analyzed dna methylation levels in the promoter of fourteen lung disease-modifier genes and showed that dna methylation levels are altered in nasal epithelial and blood cell samples from cf patients. this study disclosed slightly, but significantly differentially methylated regions that collectively may modulate lung disease severity. it also highlighted that complex relationships between genetic and epigenetic factors contribute to the phenotypic variability of cf patients.

Eligibility criteria:
inclusion criteria: * \>18 years old * homozygous for the f508del mutation exclusion criteria: * subjects who have an active cf exacerbation or a recent viral infection on the day of biological samples collection; * pregnant women; * patients who are included in interventional medical trials; * patients who had lung transplantation.

Keywords: lung disease epigenetics dna methylation modifier genes