Kornimate/medical-research-clean huggingface dataset:
pediatric liver database

Conditions: Liver Disease; Liver Transplant

Summary: the purpose of this study is to collect data to examine and characterize the clinical outcomes of pediatric patients diagnosed with any liver disease at children's hospital of wisconsin.

in this study, medical information which is routinely obtained on children with any liver diseases, or children who have had a liver transplant will be entered into a database. no extra tests are done for participating in this study, and no extra visits to the doctor are required. the clinical data collected is then entered into a database and followed longitudinally. the information obtained from this study will help researchers learn more about pediatric liver disease, therefore providing better routine clinical treatment.

Eligibility criteria:
inclusion criteria: * under 18 years of age * newly diagnosed with a liver disease, currently listed for liver transplant, or who are being considered for liver transplantation and evaluated * receive a liver transplant prior to their eighteenth birthday exclusion criteria: * patients decline participation. * patients have no liver diseases.

Keywords: liver transplant
evaluation of salivary biomarker levels of individuals with different periodontal diseases

Conditions: Periodontal Diseases

Summary: the aim of this study is; detection of leucine rich α-2 glycoprotein1 (lrg1), c-reactive protein (crp) levels in saliva samples of periodontally healthy, gingivitis and periodontitis patients and the possible correlation between these values and clinical parameters of periodontal diseases. materials and methods: samples of saliva were obtained from 60 systemically healthy non-smoker individuals with periodontitis (p, n=20), gingivitis(g, n=20) and healthy periodontium (s, n=20). full-mouth clinical periodontal measurements including probing depth (pd), clinical attachment level (cal), bleeding on probing (bop), gingival index (gi) and plaque index (pi) were also recorded. enzyme-linked immunosorbent assay (elisa) was used to determine lrg and crp levels in the biological samples.


Eligibility criteria:
inclusion criteria: * systemically healthy (the determination of healthy volunteers will be based on the statements of the patients in the anamnesis. no additional examinations will be made.) * at least twenty permanent teeth in the mouth * non-smoker * no medication for continuous use * those who have not used antibiotics, anti-inflammatory and systemic corticosteroid drugs in the last 6 months. * not in pregnancy or lactation period. * for the periodontitis group that has not received periodontal treatment in the last 6 months * for the periodontitis group; according to the evaluation made in 6 regions of each tooth, individuals with 30% or more bleeding on probing area, at least 2 teeth not adjacent to each quarter jaw with a depth of 5 mm or more and 4 mm or more attachment loss, coronal 1/3 and more on radiography (horizontal and / or vertical) bone loss * for the gingivitis group; according to the evaluation made in 6 regions of each tooth, individuals with 10% or more bleeding on probing area, having a probing depth of less than 4mm and no attachment loss * for healthy group; according to the evaluation made in 6 regions of each tooth,individuals with less than 10% bleeding on probing area, having a probing depth less than 4mm and no loss of attachment were included in the study. exclusion criteria: * any oral or systemic disease * regularly using a systemic medication * during pregnancy or lactation * received periodontal treatment within the last 6 months. * those who received antibiotic, anti-inflammatory or systemic corticosteroid medication in the last 6 months * smokers are not included in the study
educational videos to improve patient decision making and race disparities in implantable cardioverter defibrillator use

Conditions: Sudden Cardiac Arrest

Summary: the investigators will examine whether an educational video increases patient knowledge about heart failure and the risk of sudden cardiac arrest and leads to greater satisfaction with information provided as compared to usual care. additionally, the investigators will look at whether racial concordance (physician and patient being of the same race) improves satisfaction with the patient's treatment decision and disease knowledge. our hypothesis is that a video in which participants are of the same race as the patient will provide better education and more satisfaction with the treatment decision and may lead to more patients choosing icd therapy.


Eligibility criteria:
inclusion criteria: * class i primary prevention indications for an implantable cardioverter defibrillator (icd). these include: * patients with ejection fraction \<35% due to prior myocardial infarction (mi) who are at least 40 days post-mi and with new york heart association (nyha) functional class ii or iii;or * patients with nonischemic dilated cardiomyopathy (dcm) who have an lvef \< 35% and who meet criteria for nyha functional class ii or iii; or * patients with left ventricular dysfunction due to prior mi who are at least 40 days post-mi, have an left ventricular ejection fraction (lvef) \<30% and are in nyha functional class i-iii; or * patients with nonsustained ventricular tachycardia (vt) due to prior mi, lvef \<40%, and with inducible ventricular fibrillation (vf) or sustained vt at electrophysiological study; and * self identified race as black/african american or white/caucasian
validation of chinese sri questionnaire

Conditions: Chronic Obstructive Pulmonary Disease; Hypercapnic Respiratory Failure

Summary: assessment of health-related quality of life in copd patients with severe chronic respiratory failure requires appropriate and highly specific measurement tools. we attempt to validate the chinese version of the severe respiratory insufficiency questionnaire (sri)


Eligibility criteria:
inclusion criteria: 1. adult copd patients with chronic hypercapnic respiratory failure established on home noninvasive ventilation for at least 1 month 2. patients are in a clinically stable state,without any changes of medication during the previous 4 weeks. exclusion criteria: 1. patient's refusal to participate 2. patients with evidence of acute respiratory failure i.e.patients with worsening of symptoms during the previous 2 weeks, a ph ,7.35, or with signs of respiratory infection

Keywords: copd;sri;reliability;validity;
mindfulness-music intervention for adolescents and young adults with cancer

Conditions: Anxiety; Oncology; Stress

Summary: this study is evaluating how well a music therapy program works to improve anxiety and stress in adolescents and young adults receiving cancer treatment.

this research study will test how well a music therapy program works to improve anxiety and stress in adolescents and young adults receiving cancer treatment. the program is designed to incorporate music-based meditation practices and music making activities (e.g., guitar, drums) to help promote relaxation during cancer treatment.

Eligibility criteria:
inclusion criteria: * age 15 - 39 years of age * have a diagnosis of any cancer * have begun treatment for cancer and plan to receive active cancer treatment (e.g., radiation, chemotherapy, or oral chemotherapy) over the next eight weeks * signed informed consent/assent * willingness to participate in all study activities * speak/read english exclusion criteria: * prognosis \< 3 months, * self-report inability to physically interact with musical instruments (e.g., hold instruments) * documentation of significant hearing impairment (e.g., deaf).

Keywords: anxiety music therapy oncology adolescent and young adults
intratracheal umbilical cord-derived mesenchymal stem cell for the treatment of bronchopulmonary dysplasia (bpd)

Conditions: Bronchopulmonary Dysplasia

Summary: umbilical cord-derived mesenchymal stem cell has been proven effective in the experimental bronchopulmonary dysplasia (bpd).a multi-center study was designed to evaluate the safety and efficacy of the cellular therapy in extremely preterm infants at high risk for bpd.

brochopulmonary dysplasia is a severe chronic lung disease in extremely preterm infants. the morbidity of bpd is increasing in china. the preventive and therapy methods of bpd are still lacking. umbilical cord-derived mesenchymal stem cell has been proven effective in the experimental bronchopulmonary dysplasia (bpd). a multi-center study was designed to evaluate the safety and efficacy of the cellular therapy in extremely preterm infants at high risk for bpd.

Eligibility criteria:
inclusion criteria: * extremely preterm infants who remain on mechanic ventilator after 2 weeks of postnatal age * extremely preterm infants with a x-ray sign of bpd after 2 weeks of postnatal age exclusion criteria: * patients with severe congenital diseases * patients with ivh more than 3 grade * patients with severe sepsis * patients with active pulmonary hemorrhage

Keywords: bronchopulmonary dysplasia mesenchymal stem cell
hemifacial spasm and desflurane

Conditions: Hemifacial Spasm

Summary: patients are chosen to participate in this study because they will undergo a particular type of brain surgery to treat their hemifacial spasm. this surgery is called microvascular decompression (mvd) and involves the facial nerve. the facial nerve is being compressed by one or more blood vessels and this contact produces the facial twitches. the investigators do not know why a blood vessel that touches the facial nerve produces facial twitches. the investigators are interested in investigating this during your surgery. a total of 25 participants are expected to participate in this study.

"intra operative monitoring" (iom) is a standard and routine medical practice for patients having mvd surgery. iom is done to make sure that the hearing and face nerves are not accidentally bumped or damaged during surgery. after anesthetic induction, the neurophysiologist places electrodes for the nerves, on the scalp and muscles. stimulation and monitoring of muscle twitches are all common, safe and painless medical procedures. in this study, the investigators would like to measure the nerve and muscle function on the normal side and compare it to nerve and muscle function on the abnormal side during different levels of the anesthetic desflurane. in order to monitor the normal side of the face one additional set of electrodes will be placed in the facial muscles. the investigators will compare responses to three different levels of anesthetic. the technique used will be motor evoked potentials. the effect of the anesthesia on the lateral spread response will also be examined. this response is evident only on the symptomatic side. these observations will take approximately 10 to 15 minutes and will not delay or lengthen the surgery.

Eligibility criteria:
inclusion criteria: * patients referred to the neurosurgical service for microvascular decompression surgery for hfs * males and females 18 to 75 years of age * otherwise normal neurological exam * signed informed consent exclusion criteria: * botox treatment within the last three months

Keywords: hemifacial spasm microvascular decompression surgery desflurane
synergistic effects of traditional chinese medicine practices and pelvic floor muscle training

Conditions: Maternal Stress

Summary: this study was conducted within a randomized controlled trial framework using a double-blind design. participants were assigned to one of three intervention groups: the pelvic floor muscle training group (pfmt), the pelvic floor muscle training combined with the qigong group (pfmtqg), and the qigong practice group (qg). randomization was performed using a random number table. professional trainers implemented the intervention programs. researchers conducted a 12-week intervention study, with training sessions held thrice weekly. during the trial, participants agreed not to engage in other forms of physical exercise.


Eligibility criteria:
inclusion criteria: * aged 20-35 years. * within 12 months postpartum. * diagnosed with mild to moderate sui. * physically capable of participating in mild to moderate exercise. * provided written informed consent. exclusion criteria: * severe pelvic floor dysfunction. * systemic health conditions that contraindicate physical activity. * pregnant at the time of recruitment or planning pregnancy during the study * prior structured training in qigong or pfmt. * ongoing physiotherapy for pelvic floor health. * participation in other urinary incontinence research. * inability to provide informed consent due to cognitive or language barriers.
safety study of anti-influenza virus monoclonal antibody to treat influenza

Conditions: Influenza, Human

Summary: the purpose of this study is to compare the safety profile in healthy volunteers of a single intravenous administration of tcn-032 as compared with placebo.

influenza is a highly communicable acute respiratory disease that is considered to be one of the major infectious disease threats to the human population. annual vaccination is generally effective only against those strains included in the vaccine. because of the frequent emergence of divergent variants and the periodic emergence of strains with novel hemagglutinin and/or neuraminidase surface proteins that can result in global pandemics, the availability of potent antiviral agents for the prevention and/or treatment of influenza remains an urgent clinical and public health priority.

Eligibility criteria:
inclusion criteria: * healthy volunteers * normal lab tests exclusion criteria: * prior treatment with a monoclonal antibody

Keywords: influenza monoclonal antibody
effect of gastric bypass on patients with type 2 diabetes and/or dyslipidemia

Conditions: Type 2 Diabetes

Summary: this is a retrospective review of patients who have undergone bariatric surgery at vumc and who have type 2 diabetes and/or dyslipidemia. the investigators have previously found that gastric bypass significantly improves diabetes 6-12 months after surgery. the investigators are interested in looking at the longer term results after surgery.

review and record changes in the subject's medication. subjects vitals: weight, blood pressure, and fasting blood values, which include: * hba1c * fasting blood glucose * fasting insulin * lipid panel ( total cholesterol, ldl, hdl and triglycerides) were obtained.

Eligibility criteria:
inclusion criteria: patients who have had diabetes and/or dyslipidemia prior to gastric by-pass. - exclusion criteria:patients who have had type 2 diabetes that was diet controlled at time of surgery; and debilitated patients who are unable to come in for a physical exam. -

Keywords: gastric by-pass on patients with t2dm
non invasive diagnosis of pneumocystis pneumonia

Conditions: Pneumocystis

Summary: incidence and morbi-mortality of pneumocystis pneumonia (pcp) are increasing. early and fast diagnosis and treatment improve pcp prognosis. biological diagnosis is based on the detection of pneumocystis jirovecii, mainly by pcr, in broncho-alveolar lavage (bal) obtained from bronchial fibroscopy. however this invasive exam is not always possible in emergency in suspected patient and others non invasive (sputa) and/or non-targeted (bronchial aspiration) are sent to the laboratory (25% of cases, data from the grenoble university hospital). diagnosis performances of these non invasive/non-targeted samples are not clearly established. in this study, the investigators aimed to establish the diagnosis value of non-invasive and/or non-targeted respiratory samples (oral fluids, sputa and bronchial aspiration) for the pcp diagnosis, compared to the gold-standard (pneumocystis pcr on bal, beta-d-glucans testing on serum and radio-clinical records).


Eligibility criteria:
inclusion criteria: * immunocompromised patient with (i) clinical and/or radiological suspicion of pcp, and (ii) bronchial fibroscopy with contributive bal * no immediate life-threatening conditions (estimated life expectancy \>12h) * no pcp treatment or pcp treatment \< 48h * patient hospitalized in the grenoble alpes university hospital with medical insurance * informed and written consent of the patient or its related exclusion criteria: * pregnancy, breastfeeding * exclusion period of another clinical trial * deprivation of liberty
tnfα monoclonal antibody for acute spinal cord injury

Conditions: Spinal Cord Injuries

Summary: the purpose of this study is to evaluate the safety and effectiveness of subcutaneous injection of tnfα monoclonal antibody cells for the treatment of traumatic acute spinal cord injury. spinal cord injury can be divided into three phases, which are acute (within 2 weeks), sub-acute (2 weeks to 6 months), and chronic (over 6 months). the pathological process of spinal cord injury include primary injury (initial traumatic insult) and a progressive secondary injury cascade characterized by ischemia, proapoptotic signaling, peripheral inflammatory cell infiltration and the release of proinflammatory cytokines. secondary injury plays a key role in the loss of spinal cord function after trauma. so early treatment to prevent the secondary injury is the key to improve prognosis. tnfα monoclonal antibody is a tnf-α inhibitor that could control inflammatory response, and now widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and other autoimmune diseases. in this study, the investigators will treat patients with acute spinal cord injury with tnfα monoclonal antibody and compare with the control group.


Eligibility criteria:
inclusion criteria: * patients aged between 18 and 60 years * traumatic spinal cord injury * asia impairment scale a-d * the injury must be within two weeks * patients submitted written informed consent exclusion criteria: * traumatic spinal cord injury with brain injury or peripheral nerve injury * patients with severe multiple injuries and unstable vital signs * non-traumatic spinal cord injury caused by spinal tumors, hematoma, myelitis, etc. * patients with central spinal cord injury * patients with a completely transected spinal cord * patients with fever or acute infection * ongoing infectious disease, such as tuberculosis, hiv, hepatitis, syphilis, etc. * patients with malignant tumour * patients with neurodegenerative diseases, or any neuropathies * patients with ankylosing spondylitis * patients with a previous history of spinal surgery
isolated versus combined cognitive and motor high-tech rehabilitation

Conditions: Rehabilitation; Multiple Sclerosis; Cognitive Deficit; Motor Deficits

Summary: the first aim of this project is to investigate the effects of different high-tech neurorehabilitation interventions (cognitive, motor, and combined cognitive-motor) on both cognitive and motor disability outcomes in people with multiple sclerosis (ms). the second aim is to identify the cognitive and motor profiles of ms patients who benefit the most from either the combined cognitive-motor rehabilitation intervention or the isolated cognitive or motor treatments.


Eligibility criteria:
inclusion criteria: * presence of mild (one or two neuropsychological tests below the cut-off score, 5th percentile) or severe (more than two neuropsychological tests below the cut-off score, 5th percentile) cognitive impairment, * mild to moderate walking disability with expanded disability status scale (edss) between 3 and 6, * no relapse or associated steroid use in the past three months, * adequate visual and auditory capacity to operate computer software. exclusion criteria: * presence of other neurological disorders than ms, * major psychiatric disorders, * high levels of anxiety and/or depression (score\>20 for depression scale and up to 14 for anxiety scale on italian adaptation of the depression, anxiety and stress scale (dass-21), * substance abuse, * any type of rehabilitation intervention in the month prior to recruitment * pharmacological therapy not well defined and/or changed during the study * presence of paroxysmal vertigo * lower limb botulinum toxin injections within the previous 12 weeks

Keywords: rehabilitation multiple sclerosis cognitive deficits motor deficits
role of cd7 in skin inflammation and psoriasis

Conditions: Psoriasis; Inflammation

Summary: role of cd7 in skin inflammation and psoriasis

psoriasis is a debilitating, chronic inflammatory skin disorder characterized by scaly skin patches caused by infiltration of inflammatory cells into the dermis and epidermis, with secondary epidermal cell (keratinocyte) hyperproliferation. psoriasis is a complex disease and a combination of genetic and environmental factors are likely to be causative. t-cell-mediated immune process, including cytokines (eg. ifn-γ) and chemokines, play an essential role in psoriasis. susceptibility genes for psoriasis map to psors1 in the hla region at chromosome 6p21, psors2 in the chromosome 17q24-q25, and others. recently our colleagues in the academia sinica and we performed a genome-wide linkage analysis with polymorphic microsatellites in one five-generation affected psoriasis kindred, and the result revealed a close linkage at d17s928, close to cd7. cd7+ t cells produce ifn-γ when activated, and have been located in skin inflammatory lesions. therefore, in this study we first want to examine the role of cd7 in skin inflammations conditions. cd7+ cells will be stimulated by a variety of methods, and will be used to treat keratinocyte cultures or be injected intradermally to mice. we will watch for skin inflammation and possible proliferation and changes in keratinocytes. possible changes in cd7 function in patients with psoriasis will be explored, for example, polymorphisms of the cd7 gene may predispose skin inflammation and abnormal interaction with the keratinocytes. cd7- t cells, which could be derived from cd7+ cells and are enriched in skin inflammation lesions, secrete the th2 cytokine il-5. we are also interested in the mechanism and the consequences of this cd7 shift. we hope this study will be helpful in the understanding and management of skin inflammation conditions, including psoriasis.

Eligibility criteria:
inclusion criteria: clinical diagnosis of psoriasis exclusion criteria: -

Keywords: psoriasis, t cell, inflammation, cd7, cytokine