Kornimate/medical-research-clean huggingface dataset:
home-based pulmonary rehabilitation with remote monitoring in pulmonary arterial hypertension

Conditions: Pulmonary Arterial Hypertension

Summary: the purpose of this study is to test new technology and health coaching aimed to help people with pah become more physically active in their daily lives.


Eligibility criteria:
inclusion criteria: * diagnosis of pah, confirmed by right heart catheterization (mean pulmonary artery pressure of 20 mmhg or greater, pulmonary vascular resistance of 3.0 woods units or greater, pulmonary capillary wedge pressure of 15 mmhg or lower). * on pah-specific therapy which is at stable dosing (i.e., not currently titrating therapy). * nyha class ii-iii symptoms. * able to complete a six-minute walk test. exclusion criteria: * patients experiencing syncope or exertional syncope. * patients not experiencing exertional dyspnea. * inability to walk. * patients currently in pulmonary rehab or having completed pulmonary rehab within three months (unlikely to improve).
the correlation between luteal serum progesterone and live birth rate

Conditions: Infertility

Summary: the study design is an observational cohort study. level of serum p4 will be collected on day or+4 as well as on the day of embryo transfer (et) either day or+3 or or+5.


Eligibility criteria:
inclusion criteria: * signed informed consent * bmi \<35kg/m2 exclusion criteria: * no fresh embryo transfer * prior participation in the study
evaluation of patients with known or suspected heart disease

Conditions: Peripheral Artery Disease; Coronary Disease; Diabetes and Heart Failure; Dilated Cardiomyopathy; Heart Failure; Renal Artery Stenosis; Pulmonary Hypertension

Summary: in this study researchers will admit and evaluate patients with known or suspected heart disease referred to the cardiology branch of the national heart, lung, and blood institute (nhlbi). patients participating in this study will undergo a general medical evaluation, including blood tests, urine, examination, chest x-ray and electrocardiogram (ekg). in addition, patients may be asked to have an echocardiogram (ultrasound scan of the heart) and to perform an exercise stress test. these tests are designed to assess the types and causes of patient's heart diseases and to determine if they can participate in other, specific research studies.

the principal mission of the nih is the conduct of research that elucidates biological mechanisms, pathogenesis, and treatment of disease. patients with known or suspected cardiovascular diseases are referred to nhlbi cardiologists for consideration of participation in clinical research protocols. however, eligibility for participation is often uncertain from referral information or even after an outpatient evaluation. the purpose of this protocol is to permit inpatient evaluation of patients for whom participation in clinical research protocols is under consideration in order to determine protocol eligibility by means of conventional laboratory and cardiovascular testing.

Eligibility criteria:
* inclusion criteria: the following is a representative list of the types of patient presentations and potential diagnoses eligible for this protocol: 1. coronary artery disease with angina or inducible myocardial ischemia as determined by noninvasive testing. 2. cardiomyopathies including congestive phenotypes. 3. peripheral artery disease with intermittent claudication or limb-threatening ischemia. 4. renovascular disease with uncontrolled hypertension, intermittent pulmonary edema, or evidence of ischemic nephropathy. 5. upper extremity peripheral artery disease. 6. diabetes with heart failure. 7. pulmonary hypertension. exclusion criteria: pregnancy, for those patients who require catheterization-based diagnostics. inability to provide informed consent.

Keywords: cardiac diagnosis chest pain hypertrophic cardiomyopathy coronary artery disease microvascular angina cardiac investigation follow-up heart disease
md-logic artificial pancreas for automatic type 1 diabetes meals management

Conditions: Type 1 Diabetes

Summary: the mdlap (md-logic artificial pancreas)system is as an automatic system to regulate glucose levels by delivery of insulin operable in clinical trial settings. the safety of the system was proved in previous inpatient and outpatient trials in large number of patients. in the current study we aim to optimize post-prandial closed-loop glycemic control by developing an automated md-bolus calculator and to evaluate its safety and efficacy in controlling postprandial blood glucose when used together with the md-logic artificial pancreas system in type 1 diabetes patients. the study will consist of a pilot study with two segments and a main study segment. the aim of each segment is detailed below: 1. pilot study - segment 1 - hybrid meal bolus ratio the aim of this segment is to evaluate the efficacy and safety of different pre-meal bolus dosing compared to full closed-loop operation with no meal announcement. 2. pilot study - segment 2 - insulin dosing during meal in this segment we would like to test the optimal distribution of insulin delivery during the meal. 3. main study - segment 3 - automatic bolus calculator in this main segment of the study we will use the results and conclusions from the previous two pilot segments to develop the md-bolus calculator for closed-loop control use. the safety and efficacy of this automated insulin bolus calculator will be tested in a randomized cross-over study that will compare postprandial glycemic control under mdlap with and without the use of the md-bolus calculator.


Eligibility criteria:
inclusion criteria: * diabetes type 1 * age 14-25 years -\>1yr since diagnosis * insulin infusion pump therapy for at least 3 months * hba1c at inclusion ≤10% * bmi \< 95th percentile for age and sex * patients willing to follow study instructions exclusion criteria: * any condition that influence intestinal absorption or motility such as diabetic gastroparesis, celiac disease or malabsorptive states that could affect postprandial glucose absorption. * any episode of diabetic ketoacidosis within the month prior to study entry and/or severe hypoglycaemia resulting in seizure or loss of consciousness in the month prior to enrolment * any concomitant disease that may influence metabolic control * participation in any other interventional study * known or suspected allergy to trial products * any significant diseases (such as preexisting seizures or epilepsy) or conditions including psychiatric disorders, eating disorder and substance abuse that in the opinion of the investigator is likely to affect the subjects ability to complete the study or compromise patients safety * female subject who is pregnant or planning to become pregnant within the planned study duration.

Keywords: type 1 diabetes artificial pancreas closed loop
olive oil v prostate cancer foundation diet for treatment of prostate cancer

Conditions: Prostate Cancer

Summary: this study compared a plant-based, olive oil diet to the diet recommended by the prostate cancer foundation for weight loss and improvement in some laboratory biomarkers.

dietary treatment of overweight/ obese men with prostate cancer has not been well studied. as men with prostate cancer who are overweight/ obese are at an increase risk of recurrence, metastasis and mortality, elucidating a diet that will both improve biomarkers for prostate cancer and lead to long-term weight management could improve survivorship. the primary objective of this proposal is to compare a plant-based, olive oil (pboo) diet to a conventional diet for weight loss and improvement in metabolic biomarkers (specifically fasting insulin, glucose, and triglycerides) for overweight/ obese men diagnosed with prostate cancer on surveillance or who have had an asymptomatic biochemical failure after primary therapy. the secondary objective is to determine which diet will be more acceptable for long term use. participants will consume for 8 weeks each a conventional diet for treating prostate cancer and a pboo diet for weight loss and improvement in biomarkers with random assignment to the diet order. they will choose one of the diets for 6 months of follow-up. blood samples and body weight will be obtained pre- and post diet and after 6 months of follow-up and compared between the diets. based on earlier work by colleagues of the pi, it is anticipated that the pboo diet will result in better weight loss and biomarkers and will be more acceptable for long-term weight management. this protocol has the potential to elucidate a diet that will improve the body weight and survival of men with prostate cancer.

Eligibility criteria:
inclusion criteria: * prostate cancer, bmi 25.0 to 40.0 kg/m2 exclusion criteria: -

Keywords: dietary treatment
a study to evaluate the efficacy of seasonique for the treatment of cyclic pelvic pain

Conditions: Dysmenorrhea

Summary: this study is being conducted to evaluate the effects of treatment with seasonique an extended-regimen oral contraceptive that utilizes low dose ethinyl estradiol during the typical hormone-free interval. patients will receive 13 weeks of treatment with the option to extend blinded therapy for an additional 13 weeks. the overall study duration will be 6-9 months. patients will be required to record menstrual pain in a daily diary.


Eligibility criteria:
inclusion criteria: * sexually naïve and agree to abstain from sex during the study * moderate to severe menstrual-related pelvic pain * regular spontaneous menstrual cycles exclusion criteria: * any contraindication to the use of oral contraceptives * treatment with an oral contraceptive within the previous 3 months * previous treatment failure with an extended oral contraceptive regimen

Keywords: cyclic pelvic pain dysmenorrhea oral contraceptives
coconut oil to prevent mouth sores in pediatric patients receiving high dose chemotherapy

Conditions: Oral Mucositis

Summary: the purpose of this study is to learn if virgin coconut oil (vco) mouth rinse can help prevent oral mucositis. the study investigator will compare standard of care mucositis prevention rinses with the vco mouth rinse added to the standard of care mucositis prevention rinses. the severity of oral mucositis between the 2 groups will be evaluated. some of the standard of care rinses that can be used to prevent mucositis are normal saline, benadryl (diphenhydramine), mylanta, lidocaine, or other combinations.

this is a randomized, open-label study. the target population is patients ≥ 7 years to 26 years at time of consent who are planning to undergo myeloablative conditioning regimens in preparation hsct. the study will be conducted at levine children's hospital, levine children's cancer and blood disorders clinic and atrium health. subjects will be screened and consented within 28 days prior to admission. the planned treatment period for arm a (standard of care with the addition of vco mouth rinses) or arm b (standard of care) will begin at the start of subject's admission for conditioning, followed by transplant event with day of transplant defined as day 0 and continue through day +45 following transplant or hospital discharge, whichever comes first. a safety follow up visit will occur no sooner than 30 days from last study drug treatment

Eligibility criteria:
inclusion criteria: subject must meet all the following applicable inclusion criteria to participate in this study: 1. written informed consent, hipaa authorization for release of personal health information, and assent, when applicable from the subject, parent, or legal guardian. 2. age greater than or equal to 7 years to 26 years at the time of consent 3. patients planning to undergo myeloablative conditioning regimens in preparation for hsct 4. ecog performance status of less than or equal to 2 or lansky/karnofsky performance status of greater than or equal to 50 within 7 days prior to date of enrollment. 5. no evidence of mouth lesions at time of enrollment 6. ability of the subject and parent/caregiver to understand and comply with study procedures for the entire length of the study 7. able and willing to swish/spit the oral formulation exclusion criteria: subjects meeting any of the criteria below may not participate in the study: 1. allergy to tree nuts 2. planned discharge home prior to engraftment 3. using coconut oil mouth rinses within 30 days prior to enrollment 4. using additional mouthcare regimens, other than those allowed in the institutional sop, prior to admission with a plan to continue use during admission 5. patient has undergone hsct within the last 90 days prior to admission

Keywords: prevention virgin coconut oil mouth rinse
impact of suvorexant on sympathetic nerve activity and baroreflex function in chronic insomnia

Conditions: Chronic Insomnia

Summary: this study aims to evaluate the effect of suvorexant on sympathetic nerve activity and baroreflex function in subject with chronic insomnia. the investigator's central hypothesis is that suvorexant will reduce sympathetic nerve activity and improve baroreflex function when compared to placebo.

this study will utilize a randomized, double-blind, placebo-controlled experimental approach to determine the effects of 8-wk treatment with suvorexant (belsomra®) on sympathetic nerve activity and baroreflex function in male and female subjects with chronic insomnia. the study will utilize established techniques for assessing sleep (polysomnography), blood pressure (sphygmomanometer and beat-to-beat finger plethysmography), and peripheral sympathetic nerve activity (microneurography). the study will stratify enrollment based upon both age and sex (i.e., male vs. female) because these two covariates are known to influence sympathetic nerve activity and baroreflex function.

Eligibility criteria:
inclusion criteria: * minimum 3 months of clinically diagnosed insomnia * body mass index ≤35 kg/m2 * insomnia severity index (isi) \> 7 arbitrary units (i.e., mild-to-severe insomnia) * pre-menopausal women must have regular menstrual cycles (\~26-30 day cycles) and will be scheduled for microneurography 2-7 days after menstruation to consistently test during the early follicular phase (or low-hormone phase in women on contraceptives) exclusion criteria: * current or prior treatment of suvorexant. * obstructive sleep apnea defined as an apnea-hypopnea index \> 30 using an fda approved home sleep apnea screening devices as used in routine clinical practice. * participants without evidence of clinically significant obstructive sleep apnea on the screening test will undergo an overnight in-laboratory polysomnography to confirm absence of sleep apnea (apnea-hypopnea index of ≥ 30 episodes per hour) and to exclude other sleep disorders (e.g. periodic limb movement arousal index of ≥ 5 episodes per hour) * circadian rhythm sleep disorders * history of meeting dsm-v criteria of major psychiatric disorder * have been clinically-diagnosed with diabetes, cardiovascular disease, or any other unstable or serious medical condition. * current, or use within past month, of psychoactive (other than stable treatment with antidepressant or antianxiety), hypnotic, stimulant or analgesic medication (except occasional non-narcotic analgesics) * shift work or other types of self-imposed irregular sleep schedules * habitual smoking (6 or more cigarettes per week) * habitual alcohol consumption (more than 2 alcoholic drinks per day) * breastfeeding or pregnancy
difficult airway in the bariatric patient: the barintube cohort study

Conditions: Obesity; Bariatric Surgery Candidate

Summary: background: difficult airway in bariatric patients presents significant challenges during anesthesia, impacting patient safety and surgical outcomes. this study aims to estimate the incidence of difficult airway in bariatric patients undergoing surgery. materials and methods: this prospective observational cohort study will be conducted in a single center. patients over 18 years with a bmi ≥ 30 kg/m2 undergoing bariatric surgery and requiring intubation will be included. data will be collected on patient demographics, clinical characteristics, and intubation outcomes. the primary outcome is the occurrence of difficult airway, defined by specific criteria including intubation difficulty and the need for alternative airway management techniques. secondary outcomes include complications related to airway management and overall surgical outcomes. a total of 1290 patients will be included in the study to estimate the incidence of difficult airway within a confidence of 3%. conclusions: difficult airway management in bariatric patients is relatively common and is influenced by specific patient factors. the findings of this study will mainly allow the estimation of difficult airway incidence in patients with bariatric surgery under the new clinical definitions.


Eligibility criteria:
inclusion criteria: * patients over 18 years of age * patients of both genders * patients diagnosed with bmi greater than or equal to 30 kg/m2 * patients who will undergo bariatric surgery * patients who require intubation for intraoperative ariway management exclusion criteria: * patients who withdraw their consent to participate in the study.

Keywords: bariatric surgery difficult airway videolaringoscopy intubation airway managment obesity and anesthesia preoperative care
determinants of penumbra in acute ischemic stroke patients

Conditions: Acute Ischemic Stroke

Summary: the purpose of the study is to examine the influence of demographic, clinical and laboratory characteristics on the presence and size of penumbra in acute ischemic stroke patients and to determine those of them which related significantly and independently to the presence and size of penumbra. the examined factors will include demographic variables such as age, gender, ethnic background, vascular risk factors and medical history, clinical parameters such as time from stroke onset until arrival to the hospital, results of neurological evaluation by nihss and imaging findings, laboratory tests such as body temperature, blood pressure, glucose level, renal functions etc. and imaging findings - the presence and the size of collateral blood vessels, the state of carotid arteries (by cta). the possible correlation between all this parameters and the presence and the size of penumbra as detected by ctp will be further examined.


Eligibility criteria:
inclusion criteria: * acute ischemic stroke patients hospitalized in rambam health care campus between 2008-2010, and which have underwent neurological evaluation including nihss scale, brain ct, ct angio and ct perfusion. exclusion criteria: * intracranial hemorrhage of any other brain condition

Keywords: stroke penumbra determinants ct perfusion
enhanced recovery after surgery promotes the rehabilitation of patients with acute gastrointestinal perforation in perioperative period

Conditions: Acute Gastrointestinal Perforation; Enhanced Recovery After Surgery

Summary: the enhanced recovery after surgery(eras) has been gradually extended from its initial colorectal surgery to almost all surgical fields. however, there are few reports about the application value of eras in emergency surgery. the goal of this clinical trial is to evaluate the value of eras in the perioperative period of acute gastrointestinal perforation. all the patients will be treated by emergency operation. the changes of crp, pa, pct in plasma 1 hour before operation and 1,3,7 days after operation, the operation time, the amount of bleeding during operation, the recovery time of intestinal function and the time of the first meal after operation,the incidence of postoperative complications, the degree of postoperative pain, the time of first out-of-bed activity, fatigue and mental status, quality of life, the length and the cost of hospital stay will be monitored and recorded.


Eligibility criteria:
inclusion criteria: * age≥14years old and ≤80 years old * the initial diagnosis is acute gastrointestinal perforation exclusion criteria: * patients with unconsciousness,or patients with past psychiatric history * patients with shock and/or severe organ failure * patients who are pregnant * patients with severe spinal deformity who are unable to receive epidural anesthesia

Keywords: acute gastrointestinal perforation enhanced recovery after surgery perioperative period
cord blood transfusion in preterm neonates (cb-trip)

Conditions: Premature Infant Disease; Transfusion Related Complication; Fetal Hemoglobin

Summary: repeated transfusions have been associated with very poor outcome of preterm infants. fetal hemoglobin (hbf) and adult hb (hba) have different affinity for oxygen. the high level of adult hb may contribute to exacerbating the oxidative damage responsible for prematurity diseases. the investigators hypothesized that transfusing red blood cells (rbc) obtained from allogeneic cord blood (cb) of healthy full-term babies (which contains almost exclusively hbf) may prevent the non-physiological decrease of hbf in premature neonates, likewise protecting them from oxygen radical diseases. cord blood transfusion in preterms - cb trip - is a monocentric prospective nonrandomized study aimed to monitor hbf levels in preterm neonates receiving rbc transfusions from either umbilical blood of full-term healthy babies (cb-rbc) and/or from adult donors (a-rbc).

preterm neonates enrolled in this study are monitored for the level of hbf on capillary blood samples, from birth to the week 32 of postmenstrual age (pma). to fulfill the rbc transfusion requirements, rbc concentrates obtained from umbilical blood of full-term healthy babies are utilized, if available; otherwise, rbc concentrates from adult donors are assigned. for every week of pma, neonates undergo a minimum of three hbf determinations, and the median values are considered.

Eligibility criteria:
inclusion criteria: preterm neonates born at pma ≤30 weeks and/or with birth weight ≤1000 g born at the delivery room of fondazione policlinico universitario a. gemelli candidate to receive one or more rbc unit transfusion. exclusion criteria: one or more of the following criteria maternal-fetal immunization hydrops fetalis major congenital malformations associated or not with genetic syndromes previous transfusions hemorrhage at birth congenital infections (such as infections from torch complex) out-born infants the health care team deems it inappropriate to approach the infant's family for informed consent