Kornimate/medical-research-clean huggingface dataset:
investigating the benefits of a 3d camera for recording healing wound dimensions

Conditions: Chronic and Non-healing Wounds

Summary: the study will explore whether a 3d camera data can provide a more accurate baseline measurement (compared to 2d images with manual measurement) to support better clinical decision making in referrals to tissue viability.

chronic and non-healing wounds are a significant problem to manage in community and represent a significant workload in community nursing. the current management for non-healing wounds includes referral to the tissue viability service, using a 2 d photographic image with assessment information. this study will pilot the use of a 3 d camera and associated software that introduces measurement and monitoring of wounds as a specific intervention. the introduction of 3 d measurement and monitoring of wounds will be compared with usual care. with a target recruitment of 30 patients via tissue viability, the pilot will report on the feasibility of using this outcome measure and the effectiveness of monitoring on wound closure or improvement.

Eligibility criteria:
inclusion criteria: * patients must have a non-healing wound and be over 18 years of age the criteria for non-healing wounds is as per 5.1 on the community nursing referral criteria when considering referral of patients to tissue viability: 'would expect that the wounds are deteriorating, chronic, non-healing or static or there are problems with the dressing regime' patients must be willing to provide written informed consent patients must have a registered sheffield general practitioner and be referred to tissue viability for a static or deteriorating wound exclusion criteria: * patients with circumferential leg ulcers patients with deep narrow sinus where the opening is less than 10mm wounds on the face where the image would include the eyes or distinguishing features patients unable to provide written informed consent.
study of stereotactic ablative radiotherapy (sabr) in elderly stage i nsclc

Conditions: Non-Small Cell Lung Cancer

Summary: this study aims to prospectively investigate the efficacy, toxicity and quality of life (qof) of stereotactic ablative radiotherapy (sabr) using a moderate fractionation of 72 gy/6 gy/12 f (bed10 = 115 gy) in a single arm of elderly ( ≥ 70) patients with stage i (2009 uicc) non-small cell lung cancer (nsclc).

this study aims to prospectively investigate the local regional control, overall survival, treatment related toxicities and quality of life (qof) of elderly stage i nsclc patients receiving stereotactic ablative radiotherapy (sabr) with a moderate fractionation of 72 gy/6 gy/12 f (bed10 = 115 gy). patients' general characteristics, treatment modality, dose-volume histogram (dvh) parameters, toxicity profiling, quality of life, pattern of failure as well as survival time will be prospective recorded for the analysis.

Eligibility criteria:
inclusion criteria: * age ≥ 70 * pathologically or cytologically confirmed nsclc * stage t1- 2 n0m0 based on adequate workup * peripheral tumor * eastern cooperative oncology group (ecog) 0-1 * inoperable nsclc exclusion criteria: * pathologically or cytologically confirmed sclc * direct evidence of regional or distant metastasis * central tumor * past history of malignancy * past history of thoracic irradiation * past history of chemotherapy * past history of thoracic surgery * pure bronchioalveolar adenocarcinoma * active systemic, pulmonary or pleural lung diseases * pulmonary infection
the effects of yangxinshi (yxs) on the quality of life and exercise tolerance in patients with chronic heart failure

Conditions: Chronic Heart Failure

Summary: the investigators set out to evaluate the effects of the traditional chinese medicinal mixture under the brand name yangxinshi (yxs) on the prognosis in patients with chronic heart failure when it is combined with the optimal combination drug treatment of heart failure.


Eligibility criteria:
inclusion criteria: * patients newly diagnosed with heart failure or have been diagnosed with chronic heart failure * patients classified as nyha ii-iv (new york heart association) exclusion criteria: * with severe liver or renal dysfunction * with severe systematic conditions such as infection, malignant hypertension etc. * hemodynamic instability (arrhythmia, acute cardiac infarction, aortic dissection etc.) * not cooperating due to psychomotor deficiency, or with contraindications for exercise testing
tibialis posterior fatigue and plantar pressure

Conditions: Muscle Fatigue

Summary: the purpose of this study is to find out the changes in the measurable parameters of the dynamic and static position of the foot, caused by the tibialis posterior muscle which is activated by the fatigue protocol. the study includes 30 healthy patients whose socio-demographic and descriptive characteristics are held. the changes in the dynamic and static position of foot were measured by pedobarography whereas the level of fatigue was measured by borg fatigue scale.

the purpose of this study is to find out the changes in the measurable parameters of the dynamic and static position of the foot, caused by the tibialis posterior muscle which is activated by the fatigue protocol. the study includes 30 healthy patients whose socio-demographic and descriptive characteristics are held. the changes in the dynamic and static position of foot were measured by pedobarography whereas the level of fatigue was measured by borg fatigue scale. the variables were investigated using shapiro-wilk's test to determine the normality. the student's t-test for paired samples were used to analyse, means (x), standard deviations (sd), 95% confidence intervals (95%ci), mean difference and cohen's d-effect size were calculated. the significance level was set at .05. the effect size was considered 'small' if d= .20; 'medium' if .d=.5; 'large' if d= .8.

Eligibility criteria:
inclusion criteria: * all participants were currently free from congenital or traumatic deformity to either lower extremity, * a history of foot pain, * prior history of surgery to the foot and lower extremity * a traumatic injury to the ankle or foot 12 months prior to the start of data collection. exclusion criteria: * participants were excluded from this study if they had any orthopedic or neurological disorder, need to use an assistive device or orthoses.

Keywords: plantar pressure distribution muscle fatigue tibialis posterior
epidemiological, clinical and biological caracteristics of patients presenting with invasive meningococcal disease

Conditions: Meningococcal Infections

Summary: an unusual increase in cases of invasive meningococcal infection between late 2022 and early 2023. these cases sometimes had atypical presentations (large numbers of bacteremias without meningitis). the distribution of serogroups was also unusual in our center (large number of serotype y meningococcal imd). this development comes after three years marked by the corona-virus-disease-19 pandemic, which led to a profound change in the behaviors involved in the transmission of infectious diseases. barrier measures have considerably reduced the population's exposure to meningococcus, and may have encouraged a reduction in mucosal immunity to this pathogen. the end of 2022 was also marked by intense viral circulation (syncitial respiratory virus-influenza-covid), which may have favored invasive forms.

invasive meningococcal disease (imd) accounts for a small number of cases (500-600 cases/year) in mainland france. despite advances in its management, the disease is still associated with a 10-20% mortality rate and impaired quality of life in 50% of surviving patients. an unusual increase in cases of invasive meningococcal infection during the winter of 2022. these cases often had atypical presentations (large number of bacteremias without meningitis, digestive picture in the foreground). the distribution of serogroups was also unusual at our center (large number of serotype y meningococcal imd). these data appear to be confirmed by santé publique france's national data for 2022, with no warning of the spread of a hyper-virulent clone. this development comes after three years marked by the sars-cov2 pandemic, which led to a profound change in the behaviors involved in the transmission of infectious diseases . barrier measures have considerably reduced the population's exposure to meningococcus, and may have led to a reduction in mucosal immunity to this pathogen. this is particularly true of teenagers and young adults, for whom contact has fallen sharply due to the closure of schools and universities. it would be interesting to see whether this population is more affected this year than in previous years. the end of 2022 was also marked by intense viral circulation (srv-flu-covid), which could have favored invasive forms. evidence of a significant number of viral co-infections could support this hypothesis.

Eligibility criteria:
inclusion criteria: clinical diagnosis of invasive meningococcal infection (defined by the isolation of neisseria meningitis in a normaly steril site (csl, blood, articulation, ..) by pcr or culture. no exclusion criteria
the role of artificial intelligence in endoscopic diagnosis of esophagogastric junctional adenocarcinoma：a single center, case-control, diagnostic study

Conditions: Stomach Neoplasms

Summary: this is a single center, case-control, diagnostic study.the aim of this study is to use deep learning methods to retrospectively analyze the imaging data of gastrointestinal endoscopy in qilu hospital, and construct an artificial intelligence model based on endoscopic images for detecting and determining the depth of invasion of esophagogastric junctional adenocarcinoma.this study will also compare the established ai model with the diagnostic results of endoscopists to evaluate the clinical auxiliary value of the model for endoscopists.the research includes stages such as data collection and preprocessing, artificial intelligence model development, model testing and evaluation. the gastroscopy image dataset constructed by this research institute mainly includes three modes of endoscopic imaging: white light endoscopy, optical enhancement endoscopy (oe), and narrowband imaging endoscopy (nbi).


Eligibility criteria:
inclusion criteria: * this study included endoscopic images of patients aged 18 and above who underwent endoscopic examination or treatment * all patients in the case group need to be pathologically confirmed as esophageal gastric junction adenocarcinoma, and a pathologist has conducted a standardized pathological evaluation of the tumor classification of the lesion, including the overall appearance, size, differentiation type, depth of infiltration, presence or absence of lymphatic/vascular invasion, surgical margin status, etc. * the endoscopic images of the control group patients need to be confirmed by biopsy pathology or at least two experienced endoscopists (with operating experience\>5000 cases) to jointly confirm that they have clear benign manifestations exclusion criteria: * the patient has a previous history of endoscopic treatment or surgery for the esophageal gastric junction. * necessary clinical information cannot be provided during the research process (patient age, gender, lesion characteristics, endoscopic manifestations, endoscopic images, etc.) * low quality endoscopic images, such as those severely affected by bleeding, aperture, blurring, defocusing, artifacts, or excessive mucus after biopsy.
optimizing analgesia for endometrial biopsy

Conditions: Analgesia

Summary: comparison of the effectiveness of intrauterine lidocaine-paracervical block-dexketoprofen tromematol- lidocaine spray in endometrial biopsy analgesia


Eligibility criteria:
inclusion criteria: * women aged 18-75 needs endometrial biopsy exclusion criteria: * women with allergies to prilocaine, lidocaine or dexketoprofen trometamol * women with a history of severe uncontrolled cardiovascular disease, diabetes mellitus, pregnancy, vaginal, cervical, or pelvic infection, cervical cancer, or severe cervical stenosis

Keywords: endometrial biopsy intrauterine lidocaine pain management
molecular biomarkers predicting early development of endometrial carcinoma

Conditions: Cancer of Endometrium

Summary: endometrial carcinoma represents the most common gynaecological cancer and the sixth most frequent cancer among women worldwide. the 5-year survival of patients with stage i endometrial carcinoma is 75%-88% versus 50% for stage iii or 15% for stage iv disease. therefore, early detection could improve survival rates. specifically, in the most prevalent, type 1 endometrial cancer develops from hyperplastic endometrium. the aim of the study was to evaluate the utility of cancer gene mutations from endometrial biopsies towards predicting synchronous or metachronous development of malignant lesions. the aim of the study was to evaluate whether endometrial biopsies could already carry mutations in cancer genes useful for predicting or anticipating subsequent cancer development


Eligibility criteria:
inclusion criteria: * age \> 18 years old * patients subjected to endometrial biopsies with previous histopathologically negative and subsequent histopathologically positive for endometrial carcinoma * patient informed consent exclusion criteria: - endometrial carcinoma patients without a previous non-tumour biopsy were excluded

Keywords: biomarkers cancer gene mutations endometrial cancer
humanoid robot vs treatment as usual for loneliness

Conditions: Loneliness; Depression; Stress; Anxiety; Quality of Life

Summary: the investigators are aiming to compare the effects of a humanoid robot intervention to treatment as usual, on loneliness and mental health outcomes in older adults living in long-term care, through an assessor-blinded randomized controlled trial.

seventy-four (n=74) older adults experiencing loneliness in 3 long-term care homes will be randomized 1:1 to an 8-week, twice a week social intervention with the grace humanoid robot vs. a treatment as usual active control. the investigators will assess change (baseline to week 8) in (1) loneliness (primary outcome), (2) depression severity and (3) stress (secondary outcomes), as well as (4) other exploratory outcomes : anxiety, quality of life and reduction in acute healthcare utilization. the investigators will also assess the feasibility and acceptability of the intervention using qualitative methods.

Eligibility criteria:
inclusion criteria: * living in a ltc home setting in montreal * cognitively healthy, mild cognitive impairment (mci) or mild dementia (mmse score of \>20/clinical opinion of ltc homes staff members) * able to provide consent * loneliness ucla-3 score of ≥ 6 or more (moderate-severe loneliness). exclusion criteria: * do not speak english * inability to provide consent * moderate to severe dementia (mmse score \<18/diagnosis of moderate-severe dementia/clinical opinion of ltc homes staff members) * significant hearing loss * acutely unstable medical illnesses, including delirium, acute cerebrovascular/cardiovascular events within the last 6 months; having a terminal medical diagnosis with prognosis of less than 12 months * high suicide risk (e.g. active suicidal ideation and/or current/recent intent or plan).

Keywords: loneliness humanoid robot depression long-term care stress
a cross-sectional study on the correlation between screen usage and sleep and cognition in medical students

Conditions: Sleep Quality

Summary: the aim of this study is to investigate the effects of screen use within one hour before bedtime on sleep quality and cognitive function in medical graduate students, and to verify the mediating effect of sleep quality between the two. the study adopted a cross-sectional observational design and planned to enroll 508 full-time medical graduate students. the primary endpoints were evaluated using the pittsburgh sleep quality index (psqi) and standardized cognitive tests (n-back, ant, etc.), while secondary endpoints included insomnia severity, anxiety/depression regulation, gut microbiota diversity, and the interaction between physical activity and sleep. data collection includes questionnaire surveys (psqi, isi, gad-7, etc.), cognitive task testing, and analysis of gut microbiota samples. the final result will provide scientific basis for improving the sleep and cognitive health of medical graduate students.


Eligibility criteria:
1. inclusion criteria: 1. full time medical graduate student at southern medical university 2. age ≥ 18 years old 2. exclusion criteria: 1. have taken the following medications within the past month: antibiotics, probiotics, sleeping pills, laxatives, or intestinal cleansers, etc; 2. serious gastrointestinal diseases (inflammatory bowel disease, crohn's disease, gastric cancer, etc.); 3. recently (within one month) experienced major life events (such as the death of a relative, surgery);

Keywords: sleep
the hypertrophic scar prevention of bmt101.

Conditions: Hypertrophic Scar

Summary: an independent evaluator-blind, dose-escalation, untreated-controlled, within-subject, phase 2a therapeutic exploratory clinical trial

as a comparative evaluation between the control group (untreated-control) and the study group (treatment) within a subject, it was decided to assign ten subjects to each of the three dose groups.

Eligibility criteria:
inclusion criteria: * male and female adults aged 19-55 years * those who plan to undergo a revision surgery to remove hypertrophic scar resulted from a previous abdominal surgery * those who voluntarily signed the written consent and agreed to participate in the study. exclusion criteria: * pregnant or lactating women * those with clinically significant systemic disease (e.g. diabetes, hematologic disease, allergic or immunogenic systemic skin disease)

Keywords: scar prevention sirna scar
long-term effects of methadone for cancer pain

Conditions: Cancer Pain

Summary: the methadone is an useful opioid for the cancer pain treatment, mostly used in second or last line during the opioid rotation. the methadone had an anti-mnda effect, and clinicians agree that the methadone could have an effect in neuropathic cancer pain. during a previous study the investigators find that the pain was still improving after the week 2, but they had only a small number of patients still included at this stage and they cannot conclude. the investigators decide to follow up systematically all the patients undergoing a methadone treatment for cancer pain, at day 28, to study the hypothesis about the long-term pain improvement.


Eligibility criteria:
inclusion criteria: * patients with t methadone for cancer pain in opioid rotation * able to fill the questionnaire * performance status (ps) from 0 to 2 exclusion criteria: * patients ps 3 * unable to sign the informed consent

Keywords: methadone cancer pain long term effect
zenith® p-branch® endovascular graft pivotal study

Conditions: Aortic Aneurysm Abdominal

Summary: the zenith® p-branch® pivotal study is a clinical trial approved by fda to study the safety and effectiveness of the zenith® p-branch® endovascular graft in combination with the atrium icast™ covered stents in the treatment of abdominal aortic aneurysms.


Eligibility criteria:
inclusion criteria: * pararenal or juxtarenal aaa ≥5.0 cm in diameter or 2 times the normal aortic diameter * pararenal or juxtarenal aaa with history of growth ≥0.5 cm/year * saccular aneurysm with aortic diameter greater than 1.5 times the normal aortic diameter that is deemed to be at risk for rupture based upon physician interpretation exclusion criteria: * age \<18 years * life expectancy \<2 years * pregnant, breast-feeding, or planning on becoming pregnant within 60 months * inability or refusal to give informed consent by the patient or a legally authorized representative * unwilling or unable to comply with the follow-up schedule * simultaneously participating in another investigative device or drug study. (the patient must have completed the primary endpoint of any previous study at least 30 days prior to enrollment in this study.) * additional medical restrictions as specified in the clinical investigation plan * additional anatomical restrictions as specified in the clinical investigation plan

Keywords: abdominal aortic aneurysm endovascular juxtarenal pararenal fenestrated
efficacy and safety of losartan/chlorthalidone vs losartan/hydrochlorothiazide in essential arterial hypertension

Conditions: Essential Arterial Hypertension

Summary: phase iiib, randomized, double-blind, prospective, multicenter study to evaluate the efficacy and safety of the fixed-dose combination of losartan / chlorthalidone compared with losartan / hydrochlorothiazide in the treatment of patients with essential arterial hypertension.

two groups of patients will be formed, who wil start treatment with the lower dose (losartan 50 mg + chlorthalidone 12.5 mg; losartan 50 mg + hydrochlorothiazide 12.5 mg). blood pressure (bp) figures will be evaluated and, in those patients who do not reach the therapeutic goal, defined as a decrease in systolic blood pressure (sbp) / diastolic blood pressure (dbp) values of 20/10 mmhg with respect to their baseline values or bp \<140 / 90 mmhg, the dose will be escalated to the next available concentration for both treatments (losartan 100 mg + chlorthalidone 25 mg; losartan 100 mg + hydrochlorothiazide 25 mg) at 30 days or during an unscheduled visit. after two months of treatment, the bp figures obtained with the final dose and the proportion of subjects who achieved a decrease in sbp / dbp values of 20/10 mmhg or \<140/90 mmhg with respect to both combinations will be compared, and the frequency of adverse events presented will be described.

Eligibility criteria:
inclusion criteria: * any sex. * that they agree to participate in the study and give their informed consent in writing. * age between 18 and 65 years old at the beginning of the study. * patients with essential arterial hypertension with bp ≥140 / 90 mmhg and \<180/110 mmhg. * women of childbearing potential using a contraceptive method (barrier, oral hormonal, injectable, subdermal), menopausal or surgically sterile. exclusion criteria: * the drug is contraindicated for medical reasons. * glomerular filtration rate ≤30 ml / min x 1.73 m2. * hypersensitivity to any of the components of the formula or other sulfonamides. * patients treated with other diuretics. * patient with a history of vascular disease (cerebrovascular disease, acute coronary syndrome, etc.) and acute renal failure in the last 6 months. * patient with severe complications of type 2 diabetes mellitus (ketoacidosis or hyperosmolar nonketotic coma). * patients participating in another clinical study involving an investigational treatment or participated in one in the previous 4 weeks. * positive pregnancy test, women who are pregnant, breastfeeding or planning a pregnancy while conducting the study. * oncological patients (except basal cell skin cancer) or with serious diseases that, in the opinion of the investigator, have a serious prognosis or a life expectancy of less than 1 year, as well as mental illnesses. * patients diagnosed with gout. * patients whose participation in the study may be influenced (employment relationship with the research center or sponsor, inmates, etc.).

Keywords: hypertension blood pressure diuretic losartan chlorthalidone