Kornimate/medical-research-clean huggingface dataset:
retinal vascular changes in patients after coronavirus disease 2019 (covid-19)

Conditions: COVID-19

Summary: the study examines changes in retinal oximetry in patients after covid-19 disease. it aims to analyze and quantify possible retinal microvascular abnormalities that may result from possible post-inflammatory damage to the endothelium of the vessels associated with covid-19 disease. retinal vascular involvement may indicate similar changes in the vascular system in other organs.

the retinal blood vessels are the only blood vessels in the body that can be observed directly. patients with covid-19 pneumonia have been shown to have reduced macular vessel density in the foveal region. as a result, some layers of the retina atrophy, reducing oxygen consumption by the retina. based on this, it is expected that patients after covid-19 pneumonia, or after a more severe course of the disease, will have normal arterial retinal oxygen saturation but higher venous retinal oxygen saturation and lower arterio-venous difference than patients after mild disease.

Eligibility criteria:
inclusion criteria: * age over 18 years * history of laboratory-confirmed sars-cov2-infection * transparent ocular media allowing for fundus photography * signed informed consent exclusion criteria: * known eye disease that has been shown to affect retinal oxygen saturation (diabetic retinopathy, vascular occlusions, use of antiglaucoma drugs) * any other serious eye disease (advanced or decompensated glaucoma, retinitis pigmentosa, age-related macular degeneration, ocular tumors) * reduced transparency of the ocular media limiting the visualization of the ocular background and preventing a good quality image from being taken (severe dry eye syndrome, corneal scarring, cataract, significant vitreous haze, vitreous hemorrhage) * significant refractive error not allowing for sharpening of imaging examinations * previous intraocular surgery except cataract surgery if performed more than 3 months before the examination * previous intravitreal application of anti-vascular endothelial growth factor therapy or laser photocoagulation of the retina * previous severe eye injury * acute eye infection * known systemic disease affecting retinal oxygen saturation or causing changes in the ocular background (chronic obstructive pulmonary disease, multiple myeloma, malignant hypertension, hyperglobulinemia) * pregnancy, breastfeeding
molecular reclassification to find clinically useful biomarkers for systemic autoimmune diseases: case-control

Conditions: Healthy Subjects

Summary: connective tissue diseases (ctd) or systemic autoimmune diseases (sads) as they are known today are a group of chronic inflammatory conditions with autoimmune aetiology with few treatment options and difficult diagnosis.brest team contribute to perform a new classification of the following systemic autoimmune diseases in a european union's seventh framework programme. the aim of this research is to constitute a healthy volunteers cohort to compare with systemic autoimmune diseases cohort into molecular clusters instead of clinical entities through the determination of molecular profiles using several "omics" techniques.

the main objective of the precisesads project is to reclassify the individuals affected by sads into molecular clusters instead of clinical entities through the determination of molecular profiles using several "-omics" techniques. the specific objectives of this cross sectional study and sub-study are: 1. to identify a systemic taxonomy for patients with sads by producing the following data in individuals with sads and controls: genetic, epigenomic, transcriptomic, flow cytometric (from peripheral blood mononuclear and polymorphonuclear cells (pbmcs)), metabolomics and proteomic in plasma and urine, exosome analysis, classical serology (antibodies and autoantibodies), and clinical data. 2. to better characterize individual sads at the omics level. 3. to perform clustering analyses to determine the groups of individuals who, differentially from other groups, share specific molecular features (precision medicine). 4. to identify gene expression, methylation profiles through deconvolution methods comparing a mixture of cells with subpopulations determined by flow cytometry with separated cells, cytokine profiles and plasma metabolomics using mass spectrometry, in a substudy of 288 individuals. the clustering process will be data-driven with the aim to find the most homogenous and differentiated clusters of diseases that clearly separate individuals on the basis of, serological, genetic, epigenomic, cellular (cell proportions), metabolomic, proteomic (cytokines, autoantibodies) and transcriptome characteristics and differentiate them from controls and other patient clusters. a total of 2000 patients and 666 controls will be included in the study.

Eligibility criteria:
inclusion criteria: * aged 18 years or older at the time of consent * signed the informed consent form exclusion criteria: * individuals on chronic medication. * individuals suffering from any inflammatory, autoimmune, allergic or infectious condition and if possible without a history of autoimmune disease, particularly thyroid disease or other diseases that may modify cellular profiles in blood. * pregnant women.

Keywords: sads healthy volunteers molecular profiles omics techniques
medical need of oac reversal

Conditions: Atrial Fibrillation

Summary: this is a retrospective, observational, claims cohort study to assess, for adult patients initiating an oral anticoagulant for nvaf

this is a retrospective, observational, claims cohort study to assess, for adult patients initiating an oral anticoagulant for nvaf, the incidence rates of emergency surgery, major bleeding due to trauma, and major bleeding due to fracture, overall and stratified by age (\ 75). the secondary objective is to estimate the overall and age stratified incidence of cardiac tamponade and peri-cardiocentesis.

Eligibility criteria:
inclusion criteria: -\>18 year old non-valvular atrial fibrillation (nvaf) patients * prescribed dabigatran, rivaroxaban, apixaban, edoxaban or warfarin * patients with confirmed date of initiation of oacs * patients with a minimum of 6 months of enrolment data prior to index date * has an index date between 14th of march 2011 to 30 june, 2016 exclusion criteria: * patients receiving two or more oral anti-coagulants at the same time at index date * patients with prescriptions of index treatment in the 6 months prior to index date * patients without enrolment period of at least six month in the database
impact evaluation of incisional hernia on muscular and postural function

Conditions: Incisional Hernia

Summary: purpose of study is to assess perioperative functional parameters of the anterior abdominal wall muscles and postural control status in patients with large and giant incisional hernias in a controlled diagnostic study. the study involved 95 patients (100% completed) with a large or giant incisional hernia of the anterior abdominal wall. the participants were divided into three groups by type of hernia repair: bridged hernia repair, rives-stoppa procedure, or tar technique. perioperative functional parameters of the anterior abdominal wall muscles were assessed by tension dynamometry. the postural balance assessments were made by raster photostereography.


Eligibility criteria:
inclusion criteria: * big and giant incisional hernia * hernia without recurrence * age 18-75 exclusion criteria: * acute infection diseases * cancer * orthopedic diseases * terminal status * bmi\>39,9

Keywords: incisional hernia tension dynamometry raster photostereography postural balance hernia repair bridging technique rives-stoppa tar
effect of the plantago ovata husk on the lipid profile of patients with hypercholesterolemia

Conditions: Hypercholesterolemia; Cardiovascular Disease

Summary: the hypothesis of this study is that soluble fibre may contribute to a reduction of the low density lipoprotein cholesterol (ldl-c), and the combined effect with a statin may achieve an optimisation of the cholesterol-lowering effects in adults with several cardiovascular risk factors.

it has been demonstrated that high concentrations of cholesterol and low density lipoprotein cholesterol (ldl, high risk cholesterol) are the major risk factors for heart disease, myocardial infarction and angina pectoris. moreover, these conditions represent the major cause of death in the western world. of the measures established to reduce blood cholesterol levels, the introduction of consumption of dietary fibre is a novelty. the term dietary fibre defines a variety of substances that are found in plants and are resistant to digestion by human gastrointestinal enzymes. the studies performed up until now to determine the effects of fibre on blood lipids have demonstrated that consumption of soluble fibre can reduce cholesterol.

Eligibility criteria:
inclusion criteria: * levels of ldl-c between \>130 mg/dl and \<189 mg/dl * presence at least 1 of the cardiovascular risk factor defined as: * age above 45 years in men and 55 years in women * smoker * high blood pressure * hdl-c \< 40 mg/dl in men and \<46 mg/dl in women * family background of early heart disease * patients who have given informed consent * patients who will be capable of following diet guidelines exclusion criteria: * triglycerides \>350 mg/dl * history of cardiovascular disease * treatment with statins prior to the beginning of the trial and who have not dropped out at least 2 months before the beginning of the study * diabetes mellitus

Keywords: plantago ovata husk soluble fibre hypercholesterolemia cardiovascular risk factor
study to evaluate the benefit of a high frequency ventilation system during lung or breast cancer radiotherapy treatment

Conditions: Lung Cancer; Breast Cancer

Summary: that study combines high frequency percussive ventilation (hfpv) with radiotherapy treatment in patients with tumors that are moving with respiration like breast or lung cancers. the use of a high frequency percussive ventilation system leads to the cessation of respiratory motions while administering radiotherapy (rt) to tumors which allows a reduction of the amount of irradiated normal tissues and which potentially decrease radiation-induced collateral damages.

primary objective : demonstrate the clinical benefit of the hfpv coupled to thoracic radiotherapy in 2 distinct and frequent clinical situations : 1. tomotherapy for lung and left breast tumors. the investigators assume that the volume of irradiated healthy tissue will be much less when using hfpv as compared to free breathing during tomotherapy sessions . 2. in comparison with active breathing control (abc system). the investigators assume that the hfpv will lead to breathing motions cessation the same way as the abc system, but will abrogate pause times when administrating the radiotherapy. this will shorten the radiotherapy sessions for lung patients treated with stereotaxis and for breast cancer patients.

Eligibility criteria:
inclusion criteria: * breast cancer eligible for tomotherapy or linear accelerator with abc system * lung cancer eligible for curative tomotherapy and with a significant breathing movements amplitude * lung cancer eligible for ablative stereotaxis * who 0 or 1 exclusion criteria: * patients requiring oxygen or not able to lie on the back (dyspnea) * pulmonary functions altered * cardiac insufficiency * patient not able to breathe with the high frequency ventilation system * risk of pneumothorax when experiencing high frequency ventilation
treatment of hereditary angioedema prodrome with recombinant c1-esterase inhibitor (ruconest)

Conditions: Hereditary Angioedema

Summary: to assess the efficacy of recombinant human c1-esterase inhibitor in the management of hae prodrome for preventing the progression from prodrome to an acute angioedema attacks. subjects will either receive ruconest after the first 2 prodromes or during the last 2 prodromes. 5 clinic visits will occur within 24 hours of a prodrome. subjects will complete prodrome severity and angioedema attack diaries

after screening, subjects will be followed in the study for four consecutive prodromes. for prodromes designed to be treated with ruconest, the drug will be administered within 12 hours of prodromal onset and prior to the onset of objective selling. ruconset will be self-administered at home or by a healthcare professional at the recommended dose of 50 iu/kg body weight with maximum dose of 4200 iu as a slow iv injection over 5 minutes subjects will be randomized into two arms after enrollment. subjects in arm a receives ruconest after 1st and 2nd prodrome and no ruconest after 3rd and 4th prodromes. subjects in arm b receive no ruconest after 1st and 2nd prodrome and ruconest after 3rd and 4th prodromes.

Eligibility criteria:
inclusion criteria: * prior diagnosis of hae type 1 and 2, * one or more hae attacks per month, * history of 4 prodromes that proceed to angioedema attacks exclusion criteria: * history of thrombosis or arterial/venous thromboembolic attacks * history of atherosclerosis, morbid obesity, immobility * history of allergy to rabbits or products from rabbits * history of life-threatening immediate allergic reactions to c1 esterase inhibitor preparations

Keywords: prodrome
the effect of anti-cεmx on ige production

Conditions: Atopic Dermatitis

Summary: despite the success of omalizumab that neutralizes free ige in blood and interstitial fluids, treatment of many allergic disorders remains an unmet medical need. omalizumab was approved for patients having serum ige levels in the range of 30-700 iu/ml. omalizumab may not be effective for patients with much higher serum ige levels, such as those with atopic dermatitis. therefore, an alternative approach that targets ige-committed b cells directly and inhibits the synthesis of ige without binding to free ige will be attractive. anti-cεmx mab, developed by dr. tw chang in academia sinica, binds human mige+ cells, including ige-committed lymphoblasts and memory b cells. such anti-cεmx mabs should be able to activate b cell receptor (bcr) signaling, which leads to anergy or apoptosis of mige+ b lymphoblasts, and induces adcc through their fc portion. depletion of mige+ b cells by anti-cεmx treatment would inhibit the formation of ige-producing plasma cells, resulting in a long-term attenuation of ige synthesis that would eventually lead to a desensitized state in allergic patients.

this study will collect blood from patients of high serum ige levels to investigate the function of h4b12, a humanized mab specific for mige+ b cells, and compare the effects of h4b12, omalizumab, and rituxumab on the suppression of ige production and the number of ige-producing plasma cells. these blood specimens will be collected from 50 patients of atopic dermatitis or urticaria with high serum ige levels. fountain biopharma will carry out the following two in vitro assays to measure the efficacy of h4b12: * ige elisa to determine the concentration of ige. * ige elispotto determine the number of ige-producing plasma cells.

Eligibility criteria:
inclusion criteria: * male and female subjects aged ≥ 18 years * clinical diagnosis of atopic dermatitis or chronic urticaria exclusion criteria: -

Keywords: ige atopic dermatitis antibody allergy
tele-cbt following bariatric surgery: randomized control trial

Conditions: Obesity

Summary: bariatric (weight loss) surgery is the most effective treatment for extreme obesity, but surgery does not treat underlying psychological and behavioural issues. currently, psychotherapy ("talk therapy") for eating problems is not routinely offered with surgery, and many people start to regain weight one year later. objective: this study will examine if adding a convenient and accessible psychotherapy by phone one year after surgery will lead to increased weight loss two years after surgery. primary hypothesis: relative to the control group (who will get routine care), the group of individuals who get psychotherapy will have lower weights 2 years after surgery. secondary hypotheses: relative to the control group, the psychotherapy group will report significantly less maladaptive eating behaviours and medical burden, and significantly greater quality of life. method: participants recruited from the bariatric surgery programs at toronto western hospital will be randomly assigned to 1 of 2 groups: 1) control (usual standard of care) or 2) tele-cbt (a 7-session telephone-based cognitive behavioural therapy \[a type of "talk therapy"\] intervention focused on developing coping skills to improve maladaptive thoughts, emotions, and eating behaviours, specifically designed for bariatric surgery patients, delivered 1 year post-surgery). they will have their weight measured and will complete measures of eating behaviour and quality of life prior to the intervention, and again at several time points extending to 2 years post-surgery. implications: if telephone-cognitive behavioural therapy (cbt) is found to improve bariatric surgery outcomes, it could become the standard of care in canadian bariatric surgery programs and beyond, and be routinely offered to patients who cannot feasibly attend cbt sessions due to physical or practical barriers.


Eligibility criteria:
inclusion criteria: * received bariatric surgery 1 year ago * fluent in english * have internet access to complete online questionnaires. exclusion criteria: * current active suicidal ideation * current poorly controlled psychiatric illness that would render tele-cbt very difficult, including serious mental illness (i.e., psychotic disorder, bipolar disorder), severe depression (i.e., current major depressive episode diagnosis and patient health questionnaire \[phq-9\]61 score \> 20), or severe anxiety (i.e., current anxiety disorder diagnosis and generalized anxiety disorder \[gad-7\]62 score \>15) * current poorly controlled medical illness that would render tele-cbt very difficult.

Keywords: obesity bariatric surgery bariatrics cognitive therapy binge eating
comparison of esp block versus serratus block

Conditions: Postoperative Pain

Summary: total 60 patients, american society of anaesthesiology physical status i-ii aged between 18-65 who underwent totally mastectomy will recruit to the study. the patients randomly divided into two groups. ultrasound guided erector spinae plane block (esp) will perform with 15 ml bupivacaine+ 5 ml lidocaine in group esp and ultrasound guided serratus anterior plane (sap) block will perform with 5 ml bupivacaine+ 5 ml lidocaine in group sap. postoperative pain assessment will apply with 11-point numerical rating scale (nrs) and postoperative analgesic requirement will calculate and record with morphine consumption (patient controlled analgesia).

in this study, total 60 patients, american society of anaesthesiology physical status i-ii aged between 18-65 who underwent totally mastectomy will recruit. using with computer randomisation, the patients allocate into two groups. anaesthesia induction will perform with 2 mg/kg propofol, 0.6 mg/kg rocuronium and 2 microgram/kg fentanil and general anaesthesia will maintain with sevoflurane %1-2 +%40-60 o2-n20 mixture and remifentanil infusion. all of the blocks will perform under general anaesthesia. ultrasound guided erector spinae plane block (esp) will perform with 15 ml bupivacaine+ 5 ml lidocaine in group esp and ultrasound guided serratus anterior plane (sap) block will perform with 5 ml bupivacaine+ 5 ml lidocaine in group sap. postoperative pain, analgesic requirement and complications will evaluate. postoperative pain assessment will apply with 11-point numerical rating scale (nrs) and postoperative analgesic requirement will calculate and record with morphine consumption (patient controlled analgesia).

Eligibility criteria:
inclusion criteria: * asa i-ii patients * being volunteer * total mastectomy exclusion criteria: * asa iii and over * renal and hepatic failure * non volunteers * emergency procedures
web-based vs in-person personalized feedback intervention for comorbid substance use and disordered gambling

Conditions: Gambling; Alcohol Consumption; Cannabis

Summary: rates of gambling and substance use behaviors are elevated among emerging adults (ages 18-24), and these behaviors are individually and jointly associated with a host of negative consequences. evidence suggests there is significant overlap between these behaviors as well as comorbidity of associated mental disorders (i.e., pathological gambling and substance abuse/dependence). prior research suggests that a brief in-person delivered personalized feedback intervention (pfi) may be an effective method of reducing these behaviors and their associated consequences among emerging adults. thus, the purpose of this study is to determine the relative efficacy of an in-person delivered pfi versus a web-based pfi in reducing gambling, alcohol and marijuana use behaviors and related-consequences in a sample of emerging adults, as well as explore potential moderators and mediators of intervention efficacy and the longevity of intervention effects (over a period of 18-months).


Eligibility criteria:
inclusion criteria: * endorse disordered gambling behavior (including 1 or more consequence) * meet diagnostic criteria for one or more substance use disorder exclusion criteria: * not meeting inclusion criteria