Kornimate/medical-research-clean huggingface dataset:
probiotics in the management of acute rotavirus diarrhea in bolivian children

Conditions: Diarrhea; Rotavirus Infection

Summary: the purpose of this study is to determine the effect of probiotics in rotavirus acute diarrhea in children. the investigators will compare the effect of two different probiotics products.

acute diarrhea remains being the second most frequent infectious condition in children, producing a high number of admissions yearly. in children below one year of age, rotavirus represents the main etiologic agent, both in developed and developing countries. in bolivia, acute diarrhea affects about 30% of the group below 5 years of age. probiotics appear as one of the alternatives currently under discussion. also, evidence available suggests that probiotics shorten the time of diarrhea and therefore the time of rotavirus excretion. in daily practice, we are often limited by the type and number of probiotics products locally available; moreover, information about combined products is scarce. with this in mind, in this study we compared the efficacy of two commercially available products.

Eligibility criteria:
inclusion criteria: * positive stool sample for rotavirus test exclusion criteria: * severe malnourishment * severe dehydration * use of antibiotics, probiotics or nitazoxanide 2 weeks before admission * systemic infections * severe chronic disease * mixed enteric infections besides rotavirus

Keywords: acute diarrhea rotavirus probiotic children
chronic electrical stimulation of the auditory cortex for intractable tinnitus

Conditions: Hearing Disorders; Hearing Loss; Hyperacusis; Tinnitus

Summary: the purpose of this study is to determine whether chronic electrical stimulation of the primary auditory cortex is effective in the treatment of chronic, severe and intractable tinnitus

severe and chronic tinnitus - the perception of sound in one or both ears or in the head when non-external sound is present - can be disabling and difficult to treat. physiopathology of tinnitus can be considered as similar to neuropathic pain. neuropathic and central pain are treated since ten years by chronic electrical motor cortex stimulation. the hypothesis of this study is that it will be possible to treat severe tinnitus by this stimulation as neuropathic pains are treated by motor cortical stimulation. * principal objective : to evaluate the efficacy of chronic electrical stimulation of the auditory cortex for intractable tinnitus * secondary objective : to evaluate the tolerability and the safety of chronic electrical stimulation of the auditory cortex for intractable tinnitus * study design : randomized, cross over, double blind, study to evaluate the efficacy of the chronic electrical stimulation versus sham in severe and chronic tinnitus * inclusion criteria : patient \>18 years of age and \< 70 years of age permanent and chronic tinnitus during more than 2 years. a score over 19 at the sti (quality of life index for tinnitus) unilateral tinnitus • exclusion criteria : deaf person surgical or anesthetic contraindication history of psychiatric disorder or suicide epilepsia • number of subjects : 10

Eligibility criteria:
inclusion criteria: * patient \> 18 years of age and \< 70 years of age * permanent and chronic tinnitus during more than 2 years * a score over 19 at the sti (quality of life index) exclusion criteria: * deaf person * surgical or anesthetic contraindication * history of psychiatric disorder or suicide * epilepsia

Keywords: hearing disorders, hearing loss, hyperacusis, tinnitus, chronic cortical stimulation, functional magnetic resonance imaging
breathing exercise and invasive pain at hemodialysis patients

Conditions: Pain; Arteriovenous Fistula; Breathing Exercise

Summary: non-pharmacological approaches applied in the prevention of invasive pain due to cannulation in patients treated with arteriovenous fistula and hemodialysis; it is also a cost-effective method that prevents the patient from feeling pain from the application. breathing exercises are a method that can be easily applied before the cannulation procedure. although it is seen that there are limited number of studies on the subject in the literature, it was observed that the duration of breathing exercise application was short (two weeks) in one study and the duration was not specified in the other.

an average of 312 cannulations per year is performed in a patient who is treated for chronic hemodialysis and has arteriovenous fistula. patients state that they experience moderate to severe pain at a rate of 57-60.9% when accessing the arteriovenous. in cases where access to the fistula cannot be achieved at one time, patients may experience pain due to; patients experience non-compliance with dialysis treatment and their quality of life is adversely affected. this situation causes an increase in the mortality rate, especially with cardiovascular and respiratory system complications. in recent years, breathing exercise, which is one of the methods of distraction, has been used to reduce the invasive pain experienced during blood collection and cannulation procedures. by increasing lung ventilation with breathing, the amount of oxygen entering the body is maximized, and this causes relaxation in the patient. this relaxation also causes the person to relax and reduce the pain they will feel. although studies have found that breathing exercise is effective in reducing invasive pain; no information was given about the exercise method and duration. although in practice, holding the patient's breath during venipuncture and performing the cannulation procedure while giving it is a method frequently applied by the nurse, no study with high evidence supporting the situation has been found in the literature.

Eligibility criteria:
inclusion criteria: * hemodialysis treatment with arteriovenous for at least 3 months * hemodialysis treatment is applied for 3 days and 4 hours a week. * between the ages of 18-65 * pain score ≥ 2 as assessed by visual analogue scale during cannulation of the arteriovenous fistula * absence of advanced heart failure, asthma and chronic obstructive pulmonary disease * able to communicate in turkish * not having any psychiatric disorder that prevents communication * agreeing to participate in the research exclusion criteria: * inability to do breathing exercises properly * presence of infection, edema and scar tissue in the area where the arteriovenous fistula is located * using pain medication before hemodialysis treatment * two or more cannulation attempts for arteriovenous fistula in the same session * presence of neuropathy and peripheral vascular disease * pregnancy * withdrawal from the study at any stage of the research
immunogenicity of influenza vaccinations

Conditions: Influenza

Summary: this study is a randomized immunogenicity study in an enrolled cohort with active surveillance for influenza-like illness (ili). during this study, participants will be randomly assigned to receive an approved cell culture-based influenza vaccine (flucelvax) versus a licensed comparator influenza vaccine (flublok or fluzone). blood samples from participants will be collected for measurement of biomarkers of immune response at baseline (visit 1; day 1), post-vaccination (visit 2; day 29), and post-season (visit 3; day 181). participants will be asked if they wish to also provide saliva specimens at baseline (visit 1; day 1), post-vaccination (visit 2; day 29), and post-season (visit 3; day 181). serum and peripheral blood mononuclear cells (pbmc) and plasma samples will be isolated from whole blood and tested for biomarkers of vaccine immunogenicity, and duration of antibody responses. participants will receive electronic surveys via email or text message weekly asking about changes in health status and new ili symptoms; those reporting illness may be asked to provide a respiratory swab for laboratory testing for influenza and other respiratory viruses and up to 2 additional blood draws (acute \[\<10 days after symptom onset\] and convalescent \[28 days after acute visit if lab-confirmed positive for influenza\]).


Eligibility criteria:
inclusion criteria: 1. adults aged 18-64 years that have not received the current season's influenza vaccine 2. english literate 3. email or text message capability for weekly follow-up 4. intention of receiving influenza vaccine based on acip-cdc guidelines 5. willing to provide written/electronic informed consent 6. intention of being available for entire study period and able to complete all relevant study procedures, including follow-up phone calls and clinic visits exclusion criteria: 1. receipt of the current season's influenza vaccine (receipt after july 1, 2024) 2. history of severe allergic reaction after a previous dose of any influenza vaccine or to an influenza vaccine component 3. receipt of any licensed or investigational live vaccine within 6 weeks or non-live vaccine within 2 weeks prior to enrollment in this study or planning receipt of any vaccines between visits 1 and 2 of the study (approximately within 4 weeks after the receipt of study-administered vaccine) 4. history of guillain-barré syndrome 5. currently pregnant, planning to become pregnant within the first three months of the study per participant self-report 6. bleeding diathesis or condition associated with prolonged bleeding that would, in the opinion of the investigator, contraindicate intramuscular injection. 7. any condition which, in the opinion of the investigators, may pose a health risk to the participant or interfere with the evaluation of the study objectives temporary delay criteria (visit 1) 1. history of febrile illness (\> 100.0°f or 37.8°c) within the past 72 hours prior to vaccine administration

Keywords: influenza immunogenicity
nocturnal hypertension and non-dipping blood pressure

Conditions: Hypertension; Obstructive Sleep Apnea

Summary: the purpose of this study is to determine if high salt diet contributes to high nighttime blood pressure. the investigators will determine if high compared to low salt diet increases 24-hour blood pressure levels. the investigators will also determine if high salt diet affects blood vessel stiffness, cardiac output, and sleep apnea. the study will also determine how high salt diet affects the activity of certain genes related to control of blood pressure. a total of 60 participants will be enrolled in the study.


Eligibility criteria:
inclusion criteria: * nocturnal hypertension exclusion criteria: * stage 2 clinic hypertension * history of congestive heart failure * chronic kidney disease, * diabetes with insulin use * history of a cardiovascular event * pregnant or nursing * current use of continuous positive airway pressure * shift work * a known circadian rhythm disorder

Keywords: nocturnal hypertension non-dipping blood pressure obstructive sleep apnea
next4you: a fully mobile relationships based program for youth in foster care

Conditions: Pregnancy Related; Adolescent Behavior; Sexually Transmitted Diseases

Summary: the purpose of the study is to rigorously evaluate next4you, an innovative, fully mobile program featuring 6 content modules, each containing 8-10 microlessons intended to reduce rates of unintended pregnancy and sexually transmitted infections (sti) and increase essential knowledge, attitudes, and skills among young people aged 16-19 currently in the foster care system in california.

next4you will be tested using a randomized controlled trial (rct) involving approximately 500-600 young people ages 16-19 with former or current experience in the california foster care system. participants will complete an online screener that will assess eligibility (age, foster youth status, county of residence, english proficiency, and access to a device that is wi-fi or cellular enabled). participants will be randomly assigned to receive access to the next4you mobile platform and its microlessons and resources or a control website containing various health promotion materials. participants in both conditions will have four consecutive weeks to explore the content on the platform (defined as the implementation period). self-reported survey data related to attitudes, knowledge, and behavior around romantic relationships and sexual behavior are collected at baseline, as well as 3 months and 9 months after the intervention ends.

Eligibility criteria:
inclusion criteria: age, foster youth status, county of residence, english proficiency, access to a digital device that is wi-fi and/or cellular enabled - exclusion criteria: -

Keywords: pregnancy adolescence sexually transmitted infections decision making prevention education
bioelectrical impedance measurement for predicting treatment outcome in patients with newly diagnosed acute leukemia

Conditions: Acute Undifferentiated Leukemia; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Mast Cell Leukemia; Myeloid/NK-cell Acute Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia

Summary: this clinical trial studies bioelectrical impedance measurement for predicting treatment outcome in patients with newly diagnosed acute leukemia. diagnostic procedures, such as bioelectrical impedance measurement, may help predict a patient's response to treatment for acute leukemia.

primary objectives: i: to determine the feasibility of obtaining standardized phase angle measurements (bioelectrical impedance measurement) on patients hospitalized for treatment of newly diagnosed acute leukemia. ii. to evaluate the association between standardized phase angle measured at the start of therapy and treatment-related outcomes including treatment related mortality (defined as 60-day mortality) iii. evaluate the association of the day 14 standardized phase angle and treatment related outcomes, 30-day mortality, length of hospitalization, transfer to intensive care unit during induction, treatment response (14 day bone marrow response, complete remission), receipt of post-remission therapy, overall survival. iv. an exploratory analysis investigating associations with the primary and secondary outcomes using different ways to categorize the baseline standardized phase angle and, for acute myeloid leukemia (aml) patients, the standardized phase angle measure obtained just prior to the nadir marrow. outline: patients undergo bioelectrical impedance phase angle measurement on day 1 of treatment. patients with aml undergo a second measurement prior to the nadir marrow. patients also undergo bioelectrical impedance measurements prior to any invasive procedures (bone marrow biopsy, leukapheresis, peripherally inserted central catheter \[picc\] line placement, etc.). after completion of study treatment, patients are followed up for two years.

Eligibility criteria:
inclusion criteria: * hospitalized for newly diagnosed acute leukemia * receiving induction treatment while hospitalized * willing and able to provide written informed consent exclusion criteria: * presence of a pacemaker or defibrillator * patients pregnant at the time of enrollment * any condition or abnormality which may, in the opinion of the investigator, compromise the safety of patients * unable/unwilling to follow protocol requirements
interpersonal psychotherapy for adolescent girls

Conditions: Depression

Summary: this study will evaluate the efficacy of interpersonal psychotherapy for adolescents (ipt-a) for the treatment of depression and prevention of depression in maltreated and nonmaltreated girls between the ages of 13-15 years old.

child maltreatment poses a serious public health problem and heightens the risk of psychopathology across the life course. adolescence also represents a peak time for the emergence of depressive disorders particularly in girls. effective interventions to prevent and treat depression in low income adolescent girls with or without histories of maltreatment are needed. three groups will be recruited: maltreated depressive symptoms (mds), nonmaltreated depressive symptoms (nds), and a nonmaltreated nonsymptomatic comparison (nnc), comparable in ses, race/ethnicity, and household composition. the mds and nds groups will be randomized into ipt-a or enhanced care (ec). adolescent girls in these groups will receive 13 sessions of therapy. girls in the nnc group will only complete research visits. research assessments will be conducted at t1 (baseline/prior to intervention), t2 (6-weeks mid-intervention), t3 (end of intervention), t4 (1-year post) and t5 (18 months post). girls and their mothers will participate in these research sessions. a multi-level-of-analysis approach, integrating genotyping, hormone assays, cognitive testing, adolescent- and maternal-report, mother-teen observation, and dhs and school records will be utilized to assess the effectiveness of the interventions.

Eligibility criteria:
inclusion criteria: * girls * ages 13-15 years old * low ses status * live in rochester or surrounding counties * girls in the maltreated depressive symptom group will have cps-documented child maltreatment * girls in the nonmaltreated depressive symptom group will not have cps- documented child maltreatment * girls in the nonmaltreated nonsymptomatic comparison group will have no current or past mental illness and no documented child maltreatment exclusion criteria: * taking antidepressants or prescription medications for anxiety * already receiving mental health treatment * actively suicidal * diagnosed with a severe mental disorder * abusing drugs or alcohol * evidence of compromised cognitive ability * evidence of a pervasive developmental disorder * evidence of a major physical or neurological disorder * non-english speaking

Keywords: depression adolescents
rct on telerehabilitation efficacy in parkinson's disease

Conditions: Parkinson Disease

Summary: the implementation of regular prolonged, and effective rehabilitation in people with parkinson's disease is essential for ensuring a good quality of life. however, the continuity of rehabilitation care may find barriers related to economic, geographic, and social issues. in these scenarios, telerehabilitation could be a possible solution to guarantee the continuity of care. this trial aims to investigate the efficacy of non-immersive virtual reality-based telerehabilitation on postural stability in people with parkinson's disease, compared to at-home conventional rehabilitation.

parkinson's disease (pd) is a chronic degenerative pathology characterized by both motor and non-motor symptoms that may have a significant long-term impact on activities of daily living (adl). subjects with pd need continuous, intensive, and tailored rehabilitation in order to improve motor function as well as their quality of life (qol), and to reduce the risk of balance impairment and falls. thus, the implementation of regular prolonged, and effective rehabilitation in people with pd is essential for ensuring well-being. in this scenario, the delivery of rehabilitation services at distance, namely telerehabilitation (tr), is a possible solution to guarantee the continuity of care and physical exercise at home via digital healthcare. although the tr intervention has been proposed as a sustainable and innovative approach in people with pd, there are still conflicting results in the literature about its efficacy. this study aims to investigate the efficacy of non-immersive vr-based tr on postural stability in people with pd, compared to at-home conventional rehabilitation.

Eligibility criteria:
inclusion criteria: * hoehn \& yahr (h\&y) score between ≤3 (on-state); * the absence of moderate and severe dyskinesias assessed by the mds-unified parkinson's disease rating scale (mds-updrs) with a score of items 4.1 and 4.2 \< 3; * the absence of moderate and severe freezing episodes assessed by the mds-updrs with a score of items 2.13 and 3.11 \< 3; * the ability to perform the 6 minutes walking test (6mwt) between 200 m and 600 m; * age ≤ 80 years; * the absence of cognitive impairment measured by the montreal cognitive assessment (moca) total score≥17.54 ; * stabilized drug treatment; * sufficient cognitive and linguistic level to understand and comply with study procedures; * sign informed consent. exclusion criteria: * other neurological pathologies, psychiatric complications, or personality disorders; * blurred or low vision problems; * hearing and speech impairment affecting participation in the study.

Keywords: telerehabilitation parkinson balance continuity of care
an observational study on patients with rheumatoid arthritis treated with mabthera (rituximab)

Conditions: Rheumatoid Arthritis

Summary: this observational study will assess the execution, efficacy and safety of treatment with mabthera in patients with rheumatoid arthritis. data from patients receiving mabthera according to local treatment guidelines will be collected for 29 months. target sample size is 100-200 patients.


Eligibility criteria:
inclusion criteria: * adult patients, \>/= 18 years of age * rheumatoid arthritis * treatment with rituximab exclusion criteria: * unable/unwilling to give informed consent to data collection
trial of robotic versus laparoscopic-assisted radical resection for rectal cancer

Conditions: Rectal Neoplasms

Summary: this study compared robot-assisted total mesorectal excision (rtme) and laparoscopic total mesorectal excision (ltme) with regard to urinary function, sexual function and sphincter- preservation outcomes for low rectal cancer.

urinary and sexual dysfunction are recognized complications of rectal cancer surgery in men. this study compared robot-assisted total mesorectal excision (rtme) and laparoscopic total mesorectal excision(ltme) with regard to these functional outcomes.sphincter- preservation outcomes for low rectal cancer was observed as well.

Eligibility criteria:
inclusion criteria: * 1. patients who are acceptable to two surgical procedures for the robot- assisted or laparoscopy-assisted rectal cancer, are willing to randomized trial; * 2. matching the diagnostic criteria; * 3. aged 18-70 years old; * 4. preoperative tnm staging (ct, laparoscopic exploration): ct1-3n0-3m0 (excluding m1, t4); * 5. preoperative asa 3 scores; * 6. there was no history of malignancy, no other malignant tumors by preoperative examination; * 7. without undergoing definitive treatment, such as radiotherapy, chemotherapy or immunotherapy preoperatively; * 8. the informed consent form was signed by the patient himself(herself)or his principal agent; * 9. in accordance with the international erectile function questionnaire (iief) urinary function scale, the urinary sexual function are normal. exclusion criteria: * 1. age less than 18 years old or more than 70 years old; * 2. previous psychiatric patients or patients refused to sign the informed consent; * 3. attending other related clinical studies on surgical treatment of rectal cancer; * 4. the patient has a history of malignant tumor, or a combination of other malignant tumors; * 5. patients have been treated with definitive treatment: radiotherapy, chemotherapy or immunotherapy; * 6. patients had received otherper abdominal operations (except for laparoscopic cholecystectomy); * 7. asa \>3; * 8. laparoscopic surgical contraindications: such as severe heart lung disease; abdominal wall hernia; diaphragmatic hernia; coagulation disorder; portal hypertension; pregnancy, etc.; * 9. those who has been confirmed to be unable to do a radical resection (t4 stage) for local advanced tumor; * 10. those who have urination sexual dysfunction preoperatively.

Keywords: robot-assisted total mesorectal excision(rtme) laparoscopic total mesorectal excision(ltme) urinary function sexual function sphincter- preservation low rectal cancer