Kornimate/medical-research-clean huggingface dataset:
ai support in novice's decision-making for ultrasound fetal weight estimation

Conditions: Fetal Weight; Ultrasound

Summary: the scan-aid study is a prospective, randomized, controlled, and unblinded study that compares the performance of novices in ultrasound fetal weight estimation. the study evaluates the impact of two levels of ai support: a straightforward black box ai and a more detailed explainable ai.

the goal of this randomized controlled clinical trial is to learn which type of artificial intelligence (ai) effects the diagnostic accuracy of ultrasound estimation of fetal weight (efw), when performed by novices, in this study represented by medical students. the study's objectives are: * which type of artificial intelligence support system works for novices in improving the ultrasound fetal weight diagnostic accuracy? * does the artificial intelligence improve image quality, evaluate the cognitive load placed on participants when utilizing ai support, and is the ai system usable for novices? participants will be tasked with conducting an ultrasound estimated fetal weight (efw) using either a simple black box ai or a detailed explainable ai feedback system. the ai systems will assist participants in determining if they have captured the appropriate image for efw. the outcomes will then be compared to those of a control group. ultrasound procedures will be performed on pregnant women with fetuses at a gestational age of 28-42 weeks, who have previously undergone an efw by an expert sonographer or doctor at the clinic within 5 days days leading up to the examinationday. one participant of each randomization arm, will perfrom an efw on the same pregnant woman.

Eligibility criteria:
ultrasound novice participants: inclusion criteria: * medical students with no former fetal or abdominal ultrasound training. * the participants will have to understand spoken and written danish or english. exclusion criteria: • medical students who received formal fetal or abdominal training prior to the inclusion in this study. pregnant women; inclusion criteria: * the participants will have to understand spoken and written danish or english. * bmi \< 30 * gestational age: 28-42 exclusion criteria: * age \> 40 years * fefal anomaly * oligohydramnion * gestational diabetes, diabetes type 1 or 2.

Keywords: artificial intelligence fetal weight estimation novices
dry needle in management of cervicogenic headache

Conditions: Cervicogenic Headache

Summary: headache is an important health problem. it is the commonest type of all signs of illness in the people worldwide. cervicogenic headache is commonest musculoskeletal condition in physiotherapy practice. this study's main objective was to evaluate effectiveness of dry needle with exercise in decreasing pain and improving function in patients with cervicogenic headache.

50 patients were included and assigned randomly to group a and b. group-a received dry needle plus exercise and group-b received dry needle alone. baseline assessment was taken before and after treatment; treatment was given for four weeks twice a week. outcome indicators were measured by visual analog scale, neck disability index and cervical range of motion. the study findings indicate that both groups improve the symptoms of a headache. clinically better improvement was indicated by dry needle plus exercise group than dry needle alone group. as per our results, dry needle plus exercise should be preferred for the management of cervicogenic headache over dry needle alone.

Eligibility criteria:
inclusion criteria: * age between 20-50 years. * male and female both gender * worker in the office. * employed permanently. * self-motivated for working continuously for rehab. * persistent or regular pain in the neck over a span of at least 6 months. exclusion criteria: * cervical spine injury or surgery. * congenital spinal deformity. * participants having age less than 20 or elder than 50 years. * cervical radiculopathy, * the participants had experienced any recent trauma or suffering from dizzy spells, any vascular neurological disorders.

Keywords: dry needle exercise neck pain trigger point
effect of early versus delayed laparoscopic cholecystectomy in patients with grade ii cholecystitis

Conditions: Cholecystitis

Summary: the timing ofthe cholecystectomy in patients with acute cholecystitis is still controversial. in our study, we aimed toinvestigate the effect of early and delayed cholecystectomy on difficultcholecystectomy, morbidity and mortality in patients diagnosed with grade iicholecystitis according to tokyo 2018 guidelines.

the timing ofthe cholecystectomy in patients with acute cholecystitis is still controversial. in our study, we aimed toinvestigate the effect of early and delayed cholecystectomy on difficultcholecystectomy, morbidity and mortality in patients diagnosed with grade ii cholecystitis according to tokyo 2018 guidelines. patients that applied to the emergency department and diagnosed with grade ii acute cholecystitis between december 2019 and june 2021 were included in this study. cholecystectomy was performed within 7 days and 6 weeks after symptom onset. the effect of early and delayed cholecystectomy was observed. the study is single-centered and the patient group graded as grade ii according to the tokyo 2018 guideline acute cholecystitis diagnostic criteria will be included in the study. patients will decide on the treatment method to be applied with their consent. the patients will be divided into two groups as those operated in the early period (first 7 days) and those operated in the late period (\>6 weeks). the parameters to be compared were the rate of conversion from laparoscopic to open, bile duct injury and bile leakage rate, grade ii-iii complication rate in the clavien dindo complication scoring system, morbidity rate in the first 30 days postoperatively, and difficult cholecystectomy rate based on intraoperative imaging findings according to the parkland scoring system. the research will be terminated when the number of 120 patients determined by the power analysis result is reached. chi-square and student's t test will be used for the statistical evaluation of the results of the patients, respectively, for quantitative and continuous variables, and mann-whitney u test (two samples) or kruskal-wallis test (more than two samples) will be used for the analysis of abnormally distributed variables.

Eligibility criteria:
inclusion criteria: * patients with grade ii cholecystitis according to tokyo 2018 guidelines * patients older than 18 years of age exclusion criteria: * patients younger than 18 years of age * patients diagnosed with choledocholithiasis * patients with grade i or grade iii cholecystitis * pregnancy * patients unable to comply with the treatment or who could not consent to the treatment due to their mental state * patients that refused the treatment

Keywords: acute cholecystitis laparoscopic cholecystectomy
clinical performance study protocol for therascreen® kras rgq pcr kit

Conditions: Non-Small Cell Lung Cancer; Colorectal Cancer

Summary: an interventional, prospective clinical performance study protocol, for the testing of dna extracted from tumor tissue biopsy samples, using the therascreen® kras rgq pcr kit, from patients with non-small cell lung cancer and colorectal cancer, screened in amgen's clinical trial (protocol no. 20170543).

this is an interventional, prospective clinical performance study protocol, for the testing of dna extracted from tumor tissue biopsy samples (either core needle (nsclc only) or excisional biopsies), obtained from patients with non-small cell lung cancer (nsclc) and colorectal cancer (crc), using the therascreen® kras rgq pcr kit, (hereafter referred to as kras kit). up to 280 patient tissue samples (from approximately 100 clinical study sites), obtained in the amgen clinical protocol 20170543 study, will be tested using the kras kit. the testing will be performed at the investigational device clinical testing site, neogenomics laboratories, inc., 7256 s. sam houston pkwy w., suite 300, houston, texas, 77085, usa. the primary objective of the amgen clinical study is to evaluate tumor objective response rate (orr) assessed by modified recist 1.1 criteria of amg 510 as a monotherapy in patients using the clinical trial assay, therascreen® kras rgq pcr kit to assess whether to treat patients with kras g12c mutated advanced tumors (nsclc and crc). the clinical data from the study will be used to determine the drug-device efficacy to support future regulatory submissions for the device-drug combination.

Eligibility criteria:
inclusion criteria: * all patients who provided consent (by signing and dating the consent form for amgen protocol no. 20170543), may be included in the device study. exclusion criteria: * patients whose tumor tissue biopsy samples are not clinical trial assay evaluable will be excluded from the study. additionally, patients with samples identified for the study which have insufficient testing material will also be excluded, as will specimens which have undergone decalcification.
the use of domperidone for the relief of refractory upper gastrointestinal gi symptoms

Conditions: Gastroparesis

Summary: to prescribe oral domperidone for patients with upper gi symptoms who have failed or suffered adverse effects from standard medical therapy.

the primary objective of this study is to prescribe oral domperidone for patients with upper gi symptoms who have failed or suffered adverse effects from standard medical therapy

Eligibility criteria:
inclusion criteria: 1. males or females who are 18 years of age or older 2. symptoms or manifestations secondary to gastro esophageal reflux disease (gerd) (e.g., persistent esophagitis, heartburn, upper airway signs or symptoms or respiratory symptoms), gastrointestinal motility disorders such as nausea, vomiting, severe dyspepsia or severe chronic constipation that are refractory to standard therapy. exclusion criteria: 1. i. history of, or current, arrhythmias including ventricular tachycardia, ventricular fibrillation and torsade des pointes. patients with minor forms of ectopy (pacs) are not necessarily excluded. ii. clinically significant bradycardia, sinus node dysfunction, or heart block. iii. prolonged qtc (qtc\>450 milliseconds for males, qtc\>470 milliseconds for females) iv. clinically significant electrolyte disorders. 2. gastrointestinal hemorrhage or obstruction. 3. presence of a prolactinoma (prolactin-releasing pituitary tumor). 4. pregnant or breast feedings female. 5. known allergy to domperidone
treatment of cerebral radiation necrosis with gm1, a prospective study

Conditions: Radiotherapy; Nasopharyngeal Carcinoma; Cerebral Radiation Necrosis; MRI

Summary: cerebral radiation necrosis (crn) is a well-documented late complication of radiation therapy for cancers, and may have a devastating effect on the patient's quality of life (qol). however,crn was once regarded as a progressive and irreversible disease, no standard therapy has been suggested for crn. in our clinical practice, we have used monosialotetrahexosylganglioside (gm1)to treat crn, and found that gm1 can successfully reverse crn. so we carried out this prospective study to test the efficacy of gm1 for crn.


Eligibility criteria:
inclusion criteria: the necrotic mass shown on mri must be measured in two dimensions. no local or regional recurrence, no distant metastasis. karnofsky performance status of at least 70 and were supposed to live more than 6 months. exclusion criteria: * crn combined with local or regional relapse, or with distant metastasis. ② crn combined with other cerebrovascular disease. ③crn combined with the second primary malignancy. ④ crn without neurologic symptoms or signs. ⑤ crn combined with diabetes. ⑥crn patients that were supposed to live less than 6 months.
dispatcher-assisted resuscitation trial (dart)

Conditions: Heart Arrest

Summary: the purpose of this study is to determine whether dispatcher-assisted cpr instructions with compressions and ventilations versus dispatcher-assisted cpr instructions with compressions only improves survival from out-of-hospital cardiac arrests.

out-of-hospital cardiac arrest, a condition characterized by a person suddenly collapsing due to heart stoppage, is a leading cause of death in the united states. in out-of-hospital cardiac arrest, survival is dependent upon what the american heart association has termed the chain of survival which includes quick activation of the 9-1-1 system, prompt cardiopulmonary resuscitation (cpr), early defibrillation, and qualified advanced life support care (paramedic care). cpr allows for some circulation and delivery of oxygen to vital organs when the heart is no longer beating on its own. however, in some instances, the citizen bystander has not been trained in cpr, presenting a circumstance where the cardiac arrest victim may not receive cpr until the arrival of emergency medical services (ems) personnel (i.e., paramedics). the delay in cpr adversely affects outcome and dcreases the chance of survival. in response to this need, the ems division of public health - seattle and king county developed and instituted telephone cpr instructions that could be provided "on-the-spot" during a cardiac arrest by the emergency medical (9-1-1) dispatcher. the instructions are designed to be given over the phone to persons who have not had previous cpr training so that they can initiate cpr prior to the arrival of ems personnel and have been termed "dispatcher-assisted" cpr. the dispatcher instructions provided by the dispatch agencies of king county include the standard "full" cpr protocol of ventilations (breathing into the victim's mouth to inflate the lungs) and chest compressions(pumping on the patients chest to help circulate the blood). the ventilations oxygenate the blood while the chest compressions pump the oxygenated blood forward. this ems program has led to a considerable increase in the proportion of cardiac arrest victims in king county that receive citizen bystander cpr prior to ems arrival and has been associated with improved survival (appendix 1). comparison: dispatcher-assisted cpr instructions with compressions and ventillations compared to dispatcher-assisted cpr instructions with compressions only.

Eligibility criteria:
inclusion criteria: * cardiac arrest events where cpr is not ongoing but a bystander is willing to attempt with assistance exclusion criteria: * pregnancy * prisoners * cardiac arrest due to asphyxia, drowning, hanging, or electrocution

Keywords: heart arrest cardiopulmonary resuscitation dispatcher
intestinal microbiota impact for prognosis and treatment outcomes in early luminal breast cancer and pancreatic cancer patients

Conditions: Breast Cancer; Pancreas Cancer

Summary: the gut microbiota (gm) can influence as effectiveness of immunotherapy as prognosis factor in cancer patients. the goal of the study to identify gm pattern is associated with poor and favourable treatment outcomes in breast cancer and pancreatic cancer patients for further treatment strategy proper planning.


Eligibility criteria:
inclusion criteria: * untreated early hr+ her2- bc: 1. planned neoadjuvant chemotherapy: dose dense doxorubicin and cyclophosphamide (ac) x 4 every 2 weeks followed by 12 weekly paclitaxel + carboplatin every 21 days for 4 cycles 2. tanyn1-3m0 ki67\>40% g3 3. ecog 0-1 * untreated early hr+ her2- bc: 1. tanyn0m0 ki67\<20% g1 2. ecog 0-1 3. planned induction endocrine therapy (letrozole/anastrazole/tamoxifen) * untreated locally-advanced and/or borderline resectable pancreas cancer: 1. planned (neo)adjuvant chemotherapy: mfolfirinox 2. previous surgery ( only r0 resection) is allowed 3. ecog 0-1 4. histology diagnosis verification * informed consent * eligible blood\&fecal samples and tumor tissue for different time points exclusion criteria: * autoimmune disease * active steroid therapy * ecog \> 2 * any previous therapy for breast cancer * metastatic cancer * antibiotic use less than 28 days * other tumor
combination pill of losartan potassium and hydrochlorothiazide for improvement of medication compliance trial

Conditions: Hypertension

Summary: the purpose of the study is to determine whether combination pill of losartan potassium and hydrochlorothiazide will improve medication compliance among patients with high blood pressure.

despite clear evidence that blood pressure lowering treatment is beneficial for reduction of cardiovascular disease, blood pressure levels are not adequately controlled in many hypertensive patients. more intensive blood pressure lowering treatment is required to achieve maximum reduction of cardiovascular disease. combination pills of blood pressure lowering drugs could be a safe and effective strategy to achieve blood pressure target but there is no randomized evidence that established the beneficial effects of combination pills of blood pressure lowering drugs. the purpose of the study is to determine whether combination pill of losartan potassium and hydrochlorothiazide will improve medication compliance among patients with high blood pressure.

Eligibility criteria:
inclusion criteria: * aged 20 years or above * hypertension defined as blood pressure levels of \>/=140/90mmhg or current use of blood pressure lowering drugs * able to commence combination therapy of angiotensin receptor antagonists and diuretics exclusion criteria: * blood pressure measurements of \>/=200/120mmhg * previous serious adverse events due to angiotensin receptor antagonists or diuretics * known or possible pregnancy * known severe liver dysfunction * known severe kidney disease * known contraindication to angiotensin receptor antagonists or diuretics * taking \>/=4 tablets except for angiotensin receptor antagonists * ace inhibitors, thiazide or thiazide-like diuretics in the morning * current participation in another clinical trial * a high likelihood that the patient is not suitable for the study treatment

Keywords: hypertension combination pill compliance
correlation of different signs for assessment of dry eye syndrome

Conditions: Dry Eye Syndrome

Summary: dry eye syndrome (des) is a highly prevalent ocular condition inducing an inflammatory response of the ocular surface. common symptoms include ocular discomfort, visual impairment and instability of the tear film with potential damage to the ocular surface. the rationale of the present study is to compare signs as assessed with new methods such as measurement of tear film thickness, tear film osmolarity and scattering of the tear film with well established methods for assessment of the severity of des (break up time, staining of the cornea with fluorescein). additionally, impression cytology and determination of tear cytokines/chemokines will be performed to obtain information about inflammatory processes on the ocular surface.


Eligibility criteria:
inclusion criteria: * men and women aged over 18 years * history of dry eye syndrome for at least 3 months * at least 2 symptoms of dry eye syndrome (foreign body sensation, burning, photophobia, blurred vision, pain, itching) and/or tear break up time \< 10 seconds * normal ophthalmic findings except dry eye syndrome exclusion criteria: * participation in a clinical trial in the 3 weeks preceding the study * symptoms of a clinically relevant illness in the 3 weeks before the first study day * presence or history of a severe medical condition that will interfere with the study aim as judged by the clinical investigator * wearing of contact lenses * intake of dietary supplements in the 3 months preceding the study * glaucoma * treatment with corticosteroids in the 4 weeks preceding the study * topical treatment with any ophthalmic drug in the 4 weeks preceding the study except topical lubricants * ocular infection or clinically significant inflammation * ocular surgery in the 3 months preceding the study * sjögren's syndrome * stevens-johnson syndrome * pregnancy, planned pregnancy or lactating

Keywords: break up time tear film thickness tear film osmolarity objective scattering index impression cytology tear cytokines/chemokines visual acuity fluorescein staining
analysis of blood-based biomarkers of asthma

Conditions: Asthma

Summary: the purpose of this study is to analyze markers of inflammation in blood and in induced sputum for the purpose of identifying molecular markers of specific asthma phenotypes. the investigators' specific interest is demonstrating that periostin levels are higher than normal in blood. the investigators already have solid preliminary data to support this hypothesis, and our goal here is to replicate preliminary findings and extend them by examining further the characteristics of the asthma subgroup with elevated periostin levels.

this is a cross-sectional study in patients with asthma and healthy controls in which we will analyze markers of inflammation in blood and in induced sputum for the purpose of identifying molecular markers of specific asthma phenotypes. our specific interest in demonstrating that periostin levels are higher than normal in blood. we already have solid preliminary data to support this hypothesis, and our goal here is to replicate preliminary findings and extend them by examining further the characteristics of the asthma subgroup with elevated periostin levels. in this regard, we propose detailed phenotyping of the asthmatic subjects and the healthy controls, including measures in induced sputum, exhaled air and detailed physiologic measures including measures of airflow, lung volumes, and methacholine responsiveness. in earlier work we have found that periostin is a marker of th-2 driven asthma, and we will use the data collected here to further explore this possibility. the biospecimens collected here will also allow us to expand existing plasma, dna, rna, and sputum samples in the ucsf airway tissue bank, so that we can continue to build this resource for future research questions.

Eligibility criteria:
asthmatic subjects inclusion criteria 1. male and female subjects between the ages of 18 and 70 years with a history of asthma who may or may not be taking inhaled corticosteroids for asthma control. 2. physician diagnosis of asthma 3. pc20fev1 methacholine ≤ 8.0 mg/ml, except for those taking daily inhaled corticosteroids, for which the pc20 methacholine should be \< 16 mg/ml. 4. ability to provide informed consent. healthy subjects inclusion criteria 1. healthy male and female subjects with no history of asthma between the ages of 18 and 70 years. subjects should not be taking inhaled or oral corticosteroids. 2. no lifetime history of asthma or allergic rhinitis. 3. ability to provide informed consent. exclusion criteria for both subject groups 1. lung disease other than asthma. 2. history of an upper or lower respiratory tract infection in the 4 weeks preceding the study. 3. females who are pregnant or breast-feeding 4. subjects must be non-smokers (patients who have never smoked or patients who have smoked ≤5 cigarettes per month and have a total pack-year smoking history \< 10 packs). 5. use of marijuana \>1 time per month in the last year and use of marijuana in the 6 weeks prior to enrollment 6. use of recreational drugs other than marijuana in the 12 months preceding the study. 7. use of beta blocker medications

Keywords: asthma