Kornimate/medical-research-clean huggingface dataset:
treatment of candidal vulvovaginitis using cumin seed extract vaginal suppositories.

Conditions: Infection, Fungal

Summary: fungal infections have increased over the last two decades, largely because of the increasing size of the population at risk, including patients who are immunocompromised, broad-spectrum antibiotics and intravascular catheter users. essential oils and other extracts of plants have evoked interest as sources of natural products. they have been shown to possess antibacterial, antifungal, antiviral, insecticidal and antioxidant properties. to the best of our knowledge, no study has examined the efficacy of cumin seed extract on relieving vulvovaginal candidiasis in vivo.


Eligibility criteria:
inclusion criteria: 1. women were 18-49 years old and were married; 2. they had not used antibiotics, immunosuppressive drugs, or vaginal drugs 14 days before the study; 3. they did not suffer from trichomonal vaginitis, bacterial vaginitis, or cervicitis based on direct smear; 4. candidiasis culture was in agreement with clinical symptoms and patient's complaints. exclusion criteria: 1. pregnant and lactating women; 2. those who had abnormal uterine bleeding; 3. women with diabetes or autoimmune diseases; 4. women refuse to participate in the study.
developing a new mri technique to understand changes in brain tumors after treatment

Conditions: Brain Metastases; Brain Metastases, Adult; Metastatic Brain Tumor; Metastatic Brain Cancer

Summary: the purpose of this study is to develop and test a new magnetic resonance imaging (mri) technique to see if it can be used to tell the difference between tumor growth from worsening of cancer and growth from the effects of treatment in participants who have brain tumors treated with radiation therapy called stereotactic radiosurgery (srs).


Eligibility criteria:
inclusion criteria: healthy volunteers \[for study aim 1 (sa1) and study aim 2 (sa2)\] will be entered into the study if they meet the following criteria: * age ≥ 18 years * able to understand and give informed consent * no known cancer diagnosis patients \[for study aim 1 (sa1)\] will be entered into the study if they meet the following criteria: * age ≥ 18 years * able to understand and give informed consent * at least one untreated brain metastasis \> 1cm (e.g., an enhancing lesion in the brain of a patient with known systemic cancer determined likely to represent metastasis by neuroradiologist) patients \[for study aim 3 (sa3)\] will be entered into the study if they meet the following criteria: * age ≥ 18 years * able to understand and give informed consent * at least one untreated brain metastasis \> 1cm (e.g., an enhancing lesion in the brain of a patient with known systemic cancer determined likely to represent metastasis by neuroradiologist) * planned srs treatment exclusion criteria: healthy volunteers (sa1 \& sa2) and patients (sa1 \& sa3) exclusion criteria: * pregnant or breastfeeding women * pre-existing medical conditions, including the likelihood of developing seizures or claustrophobic reactions, and any greater than normal potential for cardiac arrest * age \< 18 years

Keywords: brain metastases healthy volunteers metastatic brain tumor metastatic brain cancer brain metastases, adult mri untreated brain metastasis cest-mrf chemical exchange saturation transfer magnetic resonance fingerprinting 22-191 memorial sloan kettering cancer center
direct transcranial electrical stimulation in tobacco addiction (tdcs)

Conditions: Adults (male and Female Subjects) with Tobacco Dependence

Summary: in summary, there are currently many therapeutic tools for achieving some degree of control or even cessation of tobacco addictive use. no single therapy seems to have proven itself sufficiently effective to be the preferred treatment axis in the management of this addiction. we can also point out that so far the main treatments aimed at reducing or controlling the craving phenomenon are of a pharmacological nature, thus exposing the participants to the side effects inherent to this type of treatment. in this perspective, the establishment of non invasive brain stimulation (tdcs), acting in a targeted manner on craving and whose effects would be mild and transient, appears quite justified, especially in addition to psychotherapy. in the context of the management of addictive pathologies, the choice of smoking dependence seems relevant to us insofar as this addiction represents a major public health problem.


Eligibility criteria:
inclusion criteria: * men and women over the age of 18 * nicotine dependent subjects according to the fagerström test (score ≥5) * subjects consuming daily tobacco. * subjects understanding and reading french and able to express themselves in this language. * signed informed consent to participate indicating that the subject has understood the purpose and the procedures required by the study and agrees to participate in the study and to comply with the requirements and limitations of this study * affiliation to the french social security scheme or beneficiary of such a scheme. * no other method to decrease or stop smoking at the same time as the study. exclusion criteria: * guardianship * pregnant or lactating woman * patient under ame * subject being in the exclusion period of another study or provided for by the "national volunteer file". * subjects with intracranial hypertension * subject unlikely to cooperate with the study and / or weak cooperation anticipated by the investigator. * treatment with buproprion or varenicline in progress * episode or family history of epilepsy, convulsion. * disease causing damage to the brain (aneurysm, tumor, ...). * cochlear or ocular implant. * stimulator or cardiac defibrillator. * presence of metal in the skull (clip on aneurysm, prosthesis, ...). * eczema on the scalp.

Keywords: tobacco addiction transcranial non invasive direct brain stimulation adults
oral self medication versus iv administration of pain killers after caesarian delivery

Conditions: Caesarian Section

Summary: c-section deliveries are painful and need adequate analgesia. in the same time, mothers need early rehabilitation to take care of the baby. hypothesis: early oral self administration of painkillers could be as effective as usual iv administration by nursing staff. purpose of the study: evaluation of the efficacy of a program of self administration of painkillers postoperatively of c-section delivery.

two arms: pcoa group receiving oral self administered multimodal analgesic protocol and iv group receiving same multimodal analgesic protocol administered by nursing staff.

Eligibility criteria:
inclusion criteria: * planned caesarian section exclusion criteria: * delivery bleeding which requires general anaesthetic and other surgical treatment * contraindication of the targetted anaesthetic because of hemostatis dysfunctionments * signed consent form * under 18 years old, toxicomania * do not french speacking * allergia or contraindication to imps * suffer from chronicle disease * do not affiliate to a health protection * do not want to cooperate with the medical staff

Keywords: planned caesarian section, analgesic, pcoa
identification and impact of vaginal flora anomalies among pregnant woman

Conditions: Vaginosis, Bacterial

Summary: this is a prospective multicentric study including six clinical units of gynecology and obstetrics (5 public health hospital and one private team), one research team in clinical microbiology and one center of clinical investigation (cic). there is a correlation between premature delivery and bacterial vaginosis. so, the anomalies of vaginal flora are a potential target for the campaign against prematurity. the main objective of this study is to achieve an objective and reproducible technique of identification and quantification by molecular biology of lactobacilla and all the other micro-organisms involved in vaginal flora anomalies. the secondary objectives are the exhaustive culture of bacteria, the characterisation of intermediate vaginal flora and bacterial vaginosis among pregnant woman by pcr targeting the ribosomic adn 16s coupled with clonage techniques. the number of patient to include is 1000 (time of inclusions: 24 months). the vaginal smears will be realized until 32 weeks of gestation (max: 3 taking of vaginal smears by patient).


Eligibility criteria:
inclusion criteria: * pregnant patients aged more than 18 years and more than 14 weeks of gestation but less than 28 weeks. * multiple pregnancy won't be included. * patient with a risk of premature delivery with a short cervix or a cervix measured at less than 25 mm (measure done by vaginal ultrasound of the cervix). * or patient with a past of premature delivery and/or of late abortion. * symptomatic or asymptomatic patient. * patients consulting for pregnancy follow up or hospitalized in a unit of gynecology and obstetrics involved in the study. * social security cover * written informed consent exclusion criteria: * antecedents : treated hypertension, foetal malformation, apls known, diabetes, renal disease, sle * treated with antibiotics the inclusion's day * dropping consent.

Keywords: to achieve a quality and quantitative molecular biology assay for vaginal flora abnormalities
maternal and neonatal outcomes after membrane sweeping

Conditions: Sepsis; Infection

Summary: this study aim to estimate maternal and neonatal outcomes after membrane sweeping in different group of patients.

sweeping of the membranes is a simple technique usually performed during vaginal examination, in order to initiate labour by increasing local production of prostaglandins.

Eligibility criteria:
inclusion criteria: * women with a singleton pregnancy and confirmed cephalic presentation at or after 37 weeks of gestation who are candidate for vaginal delivery were eligible for the study exclusion criteria: * women with a multiple pregnancy, nonreassuring cardiotocogram, meconium stained amniotic fluid, major fetal anomalies, hellp (hemolysis, elevated liver enzymes, and low platelets) syndrome, or severe preeclampsia and signs of intrauterine infections were not eligible. * women who are not candidates for vaginal delivery: placenta previa, breech presentation, planned repeat cesarean.

Keywords: membrane sweeping membrane stripping maternal outcomes neonatal outcomes
effect of mit for ci with anxiety

Conditions: Chronic Insomnia; Anxiety Disorders

Summary: this randomized controlled trial aims to investigate the efficacy of mindfulness intervention therapy (mit) in treating chronic insomnia (ci) comorbid with anxiety symptoms.


Eligibility criteria:
inclusion criteria: 1. diagnosed with insomnia disorder according to dsm-5 criteria. 2. pittsburgh sleep quality index (psqi) total score \> 5. 3. age 8 years or older. 4. educational level of at least junior high school. 5. voluntarily agree to participate and provide written informed consent. 6. presence of anxiety symptoms, defined as hamilton anxiety rating scale (hama) score ≥ 14. exclusion criteria: 1. presence of severe physical illnesses or major psychiatric disorders, or at risk of suicide. 2. diagnosed or suspected of having sleep breathing disorders, restless legs syndrome, circadian rhythm sleep disorders, or engaged in shift work. 3. pregnant or breastfeeding women. 4. currently undergoing any psychological therapy.
comparison of treatment failure criteria in hiv-infected children in uganda

Conditions: HIV

Summary: the main goal was to compare clinical and immunological versus clinical, immunological plus viral load criteria for switching to second-line art by comparing 48 week treatment outcomes, including survival rates, viral suppression, failure to thrive, and aids-defining illnesses for treatment experienced children randomized to two switching criteria.

the overall goal of the study was aimed at determining whether the use of the current who criteria alone (clinical and immunologic) to define treatment failure as the trigger for switching to second-line antiretroviral therapy leads to poorer 6 month and 12 month treatment outcomes when compared to combining clinical and immunologic parameters with viral load (vl) monitoring. in addition the study aimed at obtaining plasma samples from treatment experienced children, for future resistance testing. the results of this study may help guide who and national pediatric art programs on the need for routine vl monitoring for children initiating haart in resource limited settings, where virologic tests including resistance testing are not readily available or affordable.

Eligibility criteria:
inclusion criteria: * hiv-infected children, 1 year to 12 years * art experienced and enrolled in an existing treatment program that used clinical and immunologic criteria to monitor response to art. exclusion criteria: * none
the efficacy of adjunctive use of ondansetron in patients with sepsis and septic shock

Conditions: Sepsis; Septic Shock

Summary: sepsis is a systemic inflammatory response that has deleterious effects and considered the leading cause of death in critically ill patients 1 . one of the hallmarks of severe sepsis is the progressive, injurious inflammatory response to infection, mediated by the excessive release of inflammatory mediators and consequently, associated with multiple organs damage 2 . various studies have demonstrated that adverse outcomes in sepsis patients are closely related to the development of myocardial dysfunction 3 . the mortality of sepsis combined with cardiac functional insufficiency has increased significantly to 70%-90% 4 . therefore, targeting cardiac insufficiency and heart injury may represent a novel treatment strategy. several reports documented critical involvement of serotonin 5-hydroxytryptamine in the pathogenesis of sepsis. the aim of the current study is to evaluate the efficacy of ondansetron adjuvant use in patients with sepsis and septic shock.


Eligibility criteria:
inclusion criteria: male or female adult patients, aged 18 years or older with sepsis or septic shock after surgery according to the 2016 third international consensus definitions for sepsis and septic shock exclusion criteria: diagnosis of septic shock longer than 24 hours ago known or suspected disease with a strong indication or contraindication for the study drugs pregnant and lactating women.
dose escalation upper limb rehabilitation in stroke

Conditions: Stroke

Summary: a phase 1, single-ascending dose clinical trial will be conducted. this study will be designed to test increasing doses of multimodal exercise in successive cohorts of six participants (cumulative 3 + 3 design)\[22\] (figure 1). maximum dose is reached when two or more participants experience dlt. dlt, dose-limiting tolerance. the 'dose' will be defined as the ability to reach a fixed maximal level of exercise (type, duration (including session length) in the first two weeks post-stroke without experiencing dose-limiting tolerance (dlt). dlt thresholds will be based on failure to completeshould be less than 80% of prescribed 3-day rehabilitation dose due to pain, rate of perceived exertion, fatigue, or effort required. rehabilitation and measurement sessions will be held at either at the stroke or geriatric units at campus sint-jan, genk or at the rehabilitation unit at sint-barbara, lanaken and cliniques saint-luc with medical services on site. all participants will be monitored for fatigue and pain pre, during and at post-intervention daily. the researchers (pi of project \[dr peter hallet, zol\] postdoctoral researcher \[dr lisa tedesco triccas, uhasselt\] and phd/masters students \[uhasselt) will conduct the clinical tests and will conduct the rehabilitation program.


Eligibility criteria:
inclusion criteria: 1. a first-ever unilateral, diagnosed stroke by a neurologist as defined by the world health organisation, 2. been admitted to the acute hospital for rehabilitation, 3. ul hemiparesis or hemiplegia with a ≥ trace of muscle contraction (≥grade 1 at wrist extensors measured by the mrc scale and severely motor affected by score of 2 or 3 on item number 5 on the nih stroke scale (nihss), 4. the age of \> 18 years and (e) the ability to provide informed consent. exclusion criteria: 1. other neurological impairments that could interfere with the protocol such as multiple sclerosis and parkinson's 2. serious communication, cognitive and language deficits which might hamper the assessment (score of \>1 on the command item of the nihss).
effect of ginseng in type 2 diabetes

Conditions: Type II Diabetes Control

Summary: objective: we aim to evaluate longer term efficacy and safety of ag as an add-on therapy in patients with type 2 diabetes controlled by conventional treatment. materials and methods: a total of 23 type 2 patients are enrolled in the study. utilizing a double-blind, crossover design, the participants are randomized to receive either placebo or american ginseng extract (ag) 1g/meal=3g/day for 8-week, while maintained on their conventional diabetes treatment. following ≥4-week washout period the participants are crossed over to another 8-week treatment arm. throughout the study period, all individuals maintain their original diabetes treatment and regular lifestyle. the primary endpoint is hba1c, and secondary are fasting blood glucose and insulin, blood pressure, serum nitrates/nitrites (nox) and pai-1. safety parameters include liver, kidney and hemostatic functions.


Eligibility criteria:
inclusion criteria: * presence of type 2 diabetes of ≥1 year duration * bmi between 25-35kg/m\^2 * hba1c between 6.5-8.5% exclusion criteria: * patients on insulin therapy * impaired hepatic or renal function * clinically manifested diabetic complications * present cardiac problems * uncontrolled hypoglycemia * cigarette smokers * alcohol consumption (\>2 drinks per week) * taking ginseng or other herb with possible hypoglycemic effect * involvement in any other investigational drug studies * changed medication during the course of the study periods or during the washout period
describing patient with dme, their patient journey and disease progression

Conditions: Diabetic Macular Edema

Summary: this study aims to characterize patients with diabetic macular edema (dme), their progression, the treatment received and associate the functional and physiological outcomes related to the treatment.


Eligibility criteria:
inclusion criteria: all patients ≥18 years, with a dme diagnosis in at least one eye, included in the vestrum database identified during the study period (january 2015 to april 2023) exclusion criteria: patients without the information of laterality will be excluded.
incidence and spectrum of acute kidney injury in cirrhotics and assessment of new biomarkers as early predictors of acute kidney injury

Conditions: Acute Kidney Injury

Summary: 500 patients with normal renal function will be prospectively studied and incidence, spectrum and natural history of aki (acute kidney injury) will be observed in them and in 200 patients with abnormal renal function fulfilling aki (acute kidney injury) criteria will be prospectively studied for 1 year. also biomarkers will be studied and validated as early predictors of aki (acute kidney injury).


Eligibility criteria:
inclusion criteria: - group a: 500 patients of cirrhosis with normal baseline renal function will be enrolled group b : 200 patients who present with aki (acute kidney injury) will be enrolled exclusion criteria: * age \ 70 years * preexisting chronic renal disease * patients with obstructive uropathy. * cirrhosis with hcc (hepatocellular carcinoma). * advanced cardiopulmonary disease * pregnancy * patients with extrahepatic malignancy
impact of a bi-annual cdti on the incidence of epilepsy in an onchocerciasis-endemic area

Conditions: Onchocerciasis; Epilepsy

Summary: onchocerciasis is a neglected tropical disease associated with epilepsy, particularly in areas of high onchocerciasis volvulus transmission. onchocerciasis-associated epilepsy is characterised by seizures that start between the ages of five to 18 years. the tropical disease can be controlled through community-directed treatment with ivermectin (cdti). mahenge, in tanzania, had a high prevalence of onchocerciasis and epilepsy despite more than 20 years of annual cdti. hence, the tanzanian neglected tropical diseases control programme has switched from annual to bi-annually cdti since 2019. after this switch, the cdti coverage increased and was sustained in both ivermectin rounds in 2021, and the number of new epilepsy cases decreased. the latter were persons who did not take ivermectin the year they had the first seizures. hence, all ivermectin-eligible children at risk of onchocerciasis should take ivermectin at least annually. overall, increasing the frequency and coverage of the cdti programme should be considered in onchocerciasis-endemic areas with a high prevalence of epilepsy.

background: community-directed treatment with ivermectin (cdti) is used to eliminate onchocerciasis. however, despite 25 years of annual cdti in mahenge, tanzania, the prevalence of onchocerciasis and onchocerciasis-associated epilepsy remained high in certain rural villages. therefore, in 2019, bi-annual cdti was introduced in the area. this study assessed the impact of the programme on the incidence of epilepsy in four villages. methodology: door-to-door epilepsy surveys were conducted prior to (2017/18) and after (2021) implementing bi-annual cdti. all household members were screened for epilepsy symptoms using a validated questionnaire, and suspected cases were examined by a medical doctor to confirm/reject the diagnosis of epilepsy. the prevalence and annual incidence of epilepsy, including nodding syndrome, were calculated with 95% wilson confidence intervals with continuity correction. the latter was also done for cdti coverage in 2021.

Eligibility criteria:
inclusion criteria: whole population - exclusion criteria: no -
regular physical exercise in duchenne muscular dystrophy

Conditions: Muscular Dystrophy, Duchenne

Summary: this study examine whether an evidence-based individual user-preferred exercise program will increase the physical activity level in boys with duchenne muscular dystrophy (dmd).

regular physical activity is recommended in dmd. however, due to progression of muscle weakness and loss of function, a sedentary lifestyle is normal, and disuse of still functioning muscles leads to a secondary deterioration. use of steroids have proven to decrease the rate of progression, and also leads to adverse advents like obesity and osteoporosis. use of muscle strength training and aerobe exercise in dmd, may optimize muscle function, cardio-respiratory fitness and overall physical activity level, in addition to decrease possible adverse advents. in this study, children with dmd attending haukeland university hospital will be invited to participate (n≈14). the participant's physical activity level is registered during a four week baseline period and follow up. at start, 6 months and 12 months, a five day hospital stay will be conducted, both for testing and to prescribe an individual user preferred physical exercise program. the exercise program will be performed at home between the hospital visits. benefits, safety and feasibility of regular physical exercise will be examined during follow-up and end of study. for comparison of the physical activity level and motor function, dmd children attending standards of care follow-up at others norwegian regional pediatric rehabilitation clinics will be invited to participate in a control group.

Eligibility criteria:
inclusion criteria: * patients with conclusive dmd diagnosis * written consent * able to perform physical exercise and answer questions exclusion criteria: * lack of consent * cognitive disabled unable to answer questionnaire, understand instructions, and able to know what they participate in. * language difficulties

Keywords: physical therapy modalities exercise physical activity exercise program muscular dystrophy, duchenne