Kornimate/medical-research-clean huggingface dataset:
effectiveness of dn with or without mulligan two leg rotation technique on pain rom and joint dysfunction in ko

Conditions: Knee Osteoarthritis

Summary: the objective of study is to determine the effectiveness of dry needling with or without mulligan two leg rotation technique on pain, range of motion and joint dysfunction in knee osteoarthritis. the study will be a single blinded randomized controlled trial conducted at the physical therapy department of hussain memorial hospital, focusing on the treatment of knee osteoarthritis in adults aged 40 to 80 years.

the selection criteria will include patients with a confirmed diagnosis of knee osteoarthritis according to the kellgren and lawrence classification system, persistent symptoms for at least 6 months, and willingness to participate in the study. exclusion criteria will include patients with other joint pathologies, severe psychiatric disorders, unstable medical conditions, or currently enrolled in another clinical trial. the sample size will be 40 patients, and divided into two groups, with group a receiving dry needling combined with mulligan two-leg rotation technique and group b receiving only dry needling.

Eligibility criteria:
inclusion criteria: * adult patients with age 18-65 diagnosed with chronic coccydynia for at least 3 months were recruited. * participants who will be willing \& able to adhere to the study protocol. * including participants who will be attending follow-up appointments \& completing outcome measures. * participants who will be able to understand \& provide written informed consent. * participants with a complete screening of other medical conditions and previous medical records. exclusion criteria: * participants with previous surgery on the coccyx or lumbosacral spine, pregnancy or breastfeeding, history of bleeding disorders or anticoagulant use, active infection, or significant medical condition that could pose a safety risk during the procedures (gib or cesi) was omitted. * patients above the age of 65 were eliminated to reduce confounding by age-related health concerns and to provide a more homogenous study population for more accurate treatment outcomes. * participants with neurological conditions affecting pain perception or sensation were excluded. * participants with known allergies to medications used in the study (local anesthetic, steroid for injections) were not part of the study. * participation in another interventional clinical trial within the past 3 months was not included. * participants who were unable to safely undergo fluoroscopy were also excluded.
observational study of vision improvement in late stage dry amd patients

Conditions: Dry Age-related Macular Degeneration

Summary: the purpose of this study is to assess the vision improvement achieved by patients with late stage dry age-related macular degeneration who received corneal treatments by a low vision aid device.

the purpose of this study is to assess the vision improvement achieved by patients with late stage dry age-related macular degeneration who received corneal treatments by a low vision aid device. patient records for patients with at least 12 months follow-up will be analyzed to determine measures of vision improvement including best spectacle-corrected distance and near visual acuity. analyses will include descriptive statistics and correlation between outcomes and baseline characteristics.

Eligibility criteria:
inclusion criteria: 1. - male or female 2. - any race 3. - patient is at least 50 years old 4. - patient has diagnosed late stage dry age-related macular degeneration in one or both eyes. 5. - treated eyes were pseudophakic at the time of treatment. 6. - patient had moderate to severe baseline vision impairment with best spectacle-corrected distance visual acuity (cdva) of 20/63 or worse (decimal = 0.317 or less; logmar greater than or equal to 0.50) in the treated eye(s). 7. - patient cdva records are available at baseline and at 12 month post-treatment. exclusion criteria: 1. - corneal disease or disorder in either eye. 2. - increased intraocular pressure (above 20 mm hg), glaucoma or history of glaucoma. 3. - presence or history of any other condition or finding that, in the opinion of the investigator, makes the patient unsuitable for retrospective observational study. -

Keywords: dry amd
chen-style tai chi in pulmonary rehabilitation for chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: this study will evaluate the effects of chen-style tai chi compared to conventional exercise in pulmonary rehabilitation for copd patients. half of participants will receive the chen-style tai chi intervention, while the other half will receive the conventional exercise intervention. both groups will receive the same eduction and support during pulmonary rehabilitation.


Eligibility criteria:
inclusion criteria: * fev1 between 30 and 80% of the predicted normal values * fev1/fvc ratio \< 70% exclusion criteria: * patients with very severe copd (gold iv); * patients that had a copd exacerbations within the preceding 2 weeks of the baseline assessments; * significant hypoxemia at rest or during exercise (spo2 \<85%); * already following a rehabilitation program; * have physical limitations that compromises participation to a tai chi and a conventional exercise program

Keywords: copd tai chi pulmonary rehabilitation
a study to evaluate the efficacy and safety of a once-daily investigational nasal spray in adults and adolescents with perennial allergic rhinitis (par).

Conditions: Rhinitis, Allergic, Perennial

Summary: the primary objective of this study is to compare the efficacy and safety of gw685698x 100mcg once daily (qd) aqueous nasal spray with vehicle placebo nasal spray in adult and adolescent subjects (12 years of age and older) with perennial allergic rhinitis (par).

a randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the efficacy and safety of once-daily, intranasal administration of gw685698x aqueous nasal spray 100mcg for 4 weeks in adult and adolescent subjects (12 years of age and older) with perennial allergic rhinitis (par)

Eligibility criteria:
inclusion criteria: * diagnosis of perennial allergic rhinitis (par). * must comply with study procedures and be literate. exclusion criteria: * significant concomitant medical conditions. * use of corticosteroids. * use of allergy medications and some other medications during the study. * current tobacco use. * clinically significant abnormal ecg or laboratory abnormality.

Keywords: allergic rhinitis gw685698x perennial allergic rhinitis
evaluation of the contribution of low-pressure intra-abdominal insufflation for laparoscopic colic resection

Conditions: Colonic Disease

Summary: the laparoscopic surgery requires gas insufflation in the peritoneal cavity and the operator chooses the intraabdominal insufflation pressure. in general, during a conventional laparoscopy, this pressure is 12 to 15 mmhg. the reduction of the intra-abdominal pressure minimizes the parietal trauma due to the insufflation and could lead to a reduction of the postoperative pains and could allow an earlier recovery. in this study, the investigator propose to evaluate the benefits of a low pressure insufflation (6-8 mmhg) with pressure-controlled insufflator in patients with a mild or malignant colon pathology requiring surgical colic resection. the main objective of the study is to demonstrate that the laparoscopic colic resection at low pressure reduces the theoretical hospital stay of one day compared to the conventional laparoscopy.


Eligibility criteria:
inclusion criteria: * colic lesion justifying surgical resection by segmental colectomy, * surgery proposed by laparoscopy, * body mass index (bmi) ≤30 kg/m2, * written informed consent signed by the patient, * patient affiliated to the national french statutory healthcare insurance, system or beneficiary of this regimen. exclusion criteria: * probable realization of a stoma during the procedure, * robot-assisted approach, * contraindication to laparoscopic surgery, * pregnant or likely to be pregnant, * patient deprived of liberty or placed under the authority of a tutor, * patient considered geographically socially or psychologically unable to comply with the study procedure and the medical follow-up.
prevalence of sub-clinical atrial fibrillation in elderly patients with hypertension, detected using an external loop recorder

Conditions: Elderly; Hypertension; Risk Factors for Atrial Fibrillation

Summary: the assert-iii study aims to determine the incidence of sub-clinical (silent) atrial fibrillation (af) among elderly patients with hypertension and at least one other risk factor for af. this will be accomplished by monitoring with a wireless external loop monitor for 30 to 60 days.


Eligibility criteria:
inclusion criteria: patients will be eligible for inclusion if they meet all of the following: 1. age ≥ 80 years 2. history of hypertension or a blood pressure of ≥ 140/90 mmhg 3. attending a primary care clinic, or ambulatory resident of a chronic care facility 4. at least one of the following additional risk factors for developing af: 1. diabetes 2. body mass index ≥ 30 3. history of smoking 4. documented obstructive sleep apnea 5. cardiovascular disease 6. heart failure 7. left ventricular hypertrophy (on ecg or echocardiography) 5. provide written informed consent exclusion criteria: 1. ecg documented history of af or atrial flutter, with an episode duration ≥ 6 minutes 2. existing implanted pacemaker or defibrillator 3. patients considered by the investigator to be unsuitable for study follow-up because the patient: 1. is unreliable concerning the requirements for follow-up during the study and/or compliance with the use of the external loop recorder 2. has a life expectancy less that the expected study duration due to concomitant disease 3. has a condition which in the opinion of the investigator, would not allow current chronic treatment with anticoagultion -

Keywords: atrial fibrillation hypertension risk factors primary care elderly
use of intracameral moxifloxacin for prophylaxis of open globe endophthalmitis

Conditions: Endophthalmitis; Trauma, Corneal

Summary: endophthalmitis is a severe inflammatory eye condition with profound impairment of vision, which can lead to irreversible visual loss and requires immediate treatment. there is no way to completely prevent endophthalmitis, however, through prophylactic methods, it is possible to reduce its incidence. currently, the only technique that has reached category ii of evidence in reducing the risks of endophthalmitis is the use of 5% povidone-iodine eye drops, moments before surgery. in 2007, the european society of cataract and refractive surgery (escrs) released a large multicenter randomized clinical trial, with data on the reduction in the rates of endophthalmitis, using the intracameral antibiotic therapy technique of perioperative cefuroxime. however, much is discussed about the risks related to the technique, such as dilutional errors, contamination, anaphylaxis and cost-effectiveness, which still makes the conduct debatable. the study evaluates the use of intracameral moxifloxacin 0.5% (vigamox®) as prophylaxis in cases of endophthalmitis after open ocular trauma;


Eligibility criteria:
inclusion criteria: * open globe trauma exclusion criteria: * endophthalmitis at the beginning
a study for patients with type 2 diabetes mellitus

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of the study is to compare the human insulin inhalation powder plus oral anti-hyperglycemic medication with injected insulin (neutral protamine hegedom insulin) plus oral anti-hyperglycemic medication on lowering the blood sugar level.


Eligibility criteria:
inclusion criteria: 1. type 2 diabetes mellitus for at least 6 months 2. one or more oral antihyperglycemic medications for at least 12 weeks 3. hba1c equal to or greater than 7.0%, and equal to or less than 10.5% 4. nonsmokers, have not smoked for at least 6 months and agree not to smoke (cigars, cigarettes, or pipes) or use smokeless tobacco for the duration of the study 5. satisfactory lung function results to meet the requirement of the study exclusion criteria: 1. previously received any form of inhaled insulin 2. have a current diagnosis or past history of asthma, chronic obstructive pulmonary disease or other clinically relevant lung disease 3. history or presence of liver disease 4. history or presence of kidney disease
inter costal catheters for video-assisted thoroscopic (vats) lobectomy

Conditions: Lung Cancer Patients

Summary: a pilot study to observe satisfaction of analgesia with intercostal catheters after vats lobectomy.

pain and satisfaction with pain treatment is investigated in a population after vats lobectomy.

Eligibility criteria:
inclusion criteria: age of consent (ie age\>=18) eligible for lobectomy able to comply willing to register postoperatively - exclusion criteria: * do not understand danish

Keywords: lung cancer vats lobectomy
comparison of treatment effect of chinese medicine and western medicine on depression in china and america

Conditions: Depression

Summary: comparison of different assessment methods to evaluate the treatment efficacy of chinese medicine on minor and mild depression.

significant differences show on the evaluation of treatment efficacy of chinese medicine on depression in china and america. choose minor and mild depression patients as trials. one hundred and sixty trials will be included and randomly divided into chinese medicine group (n=40), acupuncture group (n=40), traditional chinese medicine psychology group (n=40) and physical treatment group (n=40). time points of assessment are before treatment, 1 week, 2 weeks, 4weeks, 6 weeks and 12 weeks post treatment.the assessment tools are series of psychological questionnaires. and study the mechanism of treatment efficacy assessment variances by different methods.

Eligibility criteria:
inclusion criteria: * according with icd-10 criteria of depression; * age 16-70; * antidepressant and other psychiatric drugs have not been had two weeks before the trial, or the drugs above had been used but have cleaning period of two weeks; * level of education is higher than junior middle school; * course of disease is more than two weeks; * volunteer to join and signed the informed consent exclusion criteria: * pregnancy or lactation; * severe depression or have serious suicidal tendencies * long distance or other causes who can not adherence to treatment

Keywords: depression chinese herb acupuncture psychotherapy transcranial magnetic stimulation
botswana study of uc-781 vaginal microbicide

Conditions: HIV Infections

Summary: this study will test the safety, side effects, and acceptability of two strengths of uc-781 gel when used by women and men in botswana for two weeks.

45 women and 45 men, all healthy and sexually active, 21-45 years old, without hiv infection, will be enrolled in francistown and gaborone, botswana. volunteers will be randomized to receive either 0.1% or 0.25% uc-781 carbomer gel or placebo gel (3 arms. women will be instructed to apply gel intravaginally, morning and evening, and prior to sex (always with male condom use) for 14 consecutive days. men will be instructed to apply gel topically for 14 consecutive nights, before bed, allow to dry overnight, and wash it off in the morning. additionally instructed never to use gel during sex but always to use condoms. volunteers will be seen weekly for evaluation of symptoms, laboratory toxicities, genital exam findings (with colposcopy for women, and plasma drug levels. acceptability will be assessed in focus groups in the month after completing gel use.

Eligibility criteria:
inclusion criteria: * 21-45 years old * citizen of botswana * willing to use condoms for 14 days * pap smear (normal, inflammation, ascus) * regular menses or amenorrhea * lives within 1 hour of a study clinic * pass comprehension test * provide written informed consent exclusion criteria: * genital mucosal disruption at screening * genital surgery within past 8 weeks * pregnant within past 8 weeks * currently breastfeeding * prior hysterectomy * plans to move within 2 months * alt, ast, total bilirubin, or creatinine grade 2 or above * prothrombin or partial thromboplastin time grade 2 or above * in other drug/vaccine safety trial * has more than one sexual partner in past month * unwilling/unsure they can have sex at least twice weekly for 2 weeks * any other condition that investigator believes will interfere with the evaluation of study objectives

Keywords: microbicide hiv prevention botswana preventing acquisition of hiv infection hiv seronegativity
safety and preliminary efficacy study of mts-01 for the prevention of alopecia induced by whole brain radiotherapy

Conditions: Alopecia

Summary: the purpose of this study is to determine if mts-01 is effective in preventing radiotherapy-induced hair loss in patients receiving whole brain radiotherapy

hair loss (alopecia) occurs commonly as a result of external beam radiotherapy to the brain, and contributes to the social isolation and distress of patients with cancer. mts-01 is a topical gel formulation that can be applied to the scalp during delivery of radiotherapy

Eligibility criteria:
inclusion criteria: * is \>/= 18 years of age * has metastatic cancer to the brain for which palliative or prophylactic whole brain radiotherapy is recommended. a histological diagnosis of cancer will be required, however, a biopsy of the brain metastases will not be required * can understand and sign the irb/iec approved informed consent, can communicate with the investigator, and can understand with the requirements of the protocol * has signed the hipaa authorization exclusion criteria: -

Keywords: radiotherapy induced
broncho-vaxom (om 85 bv) in children suffering from atopic dermatitis

Conditions: Atopic Dermatitis

Summary: the objective of this pilot double-blind study was to evaluate the efficacy and the safety of broncho-vaxom 1 capsule (3.5 mg) per day for 9 months compared to placebo on the evolution of the disease in children suffering from atopic dermatitis (ad).

children outpatients of both sexes, aged 6 months to 7 years, with ad confirmed by haniffin-rajka or williams et al, and an ad score (scorad) between 25 and 70 were included and followed for 9 months. patients were randomized to receive either broncho-vaxom 1 capsule (3.5 mg) per day or the corresponding placebo over 9 months. children under general corticotherapy within one month of study start, patients with immunodeficiency, patient's affected body surface area less than 15% or greater than 70% or with known allergy to desonide were excluded. outcome measures were a comparisons between the two groups in the number of ad flares during the study after the first month of treatment. secondary outcome measures were comparisons between the two groups based on scorad evolution, area of eczema, amount of corticoids used and parents/investigator assessments.

Eligibility criteria:
inclusion criteria: * male or female children aged 6 months to 7 years (in eighth year of life) * children with atopic dermatitis (hanifin-rajka or williams et al criteria) with affected body surface area ≥15% and ≤ 70% * 25 ≤ scorad ≤ 70 * written informed consent obtained from the parents/legal guardian (and the child if applicable) exclusion criteria: * children under general corticotherapy within one month of study start * children with immunodeficiency * children with malignant disease * children with scorad\ 70 * children with affected body surface area \ 70% * children with autoimmune disease * children under immunosuppressive or immunostimulating therapy within 1 month of study start * children whose parents or guardians are unable to comply with the requirements of the protocol e.g.completion of patient's diary card * children with a known allergy or previous intolerance or known hypersensitivity to the trial drug or any of the corticoids used * participation in another clinical trial and/or treatment with an experimental drug within 3 months of study start and during present trial
short term intermittent fasting and insulin resistance

Conditions: Diabetes Mellitus; Non-alcoholic Fatty Liver Disease; Metabolic Syndrome; Obesity

Summary: the purpose of the study is to determine the effect of intermittent fasting on insulin secretion and insulin sensitivity in skeletal muscle and fat distribution.

approximately 250.000 patients are diagnosed with type 2 diabetes (t2dm) in denmark, and world-wide close to 350 million people suffer from diabetes. t2dm develops in genetically susceptible individuals as a result of excess energy intake and insufficient amount of daily physical activity. the pathophysiology encompasses a mismatch between the insulin secretory capacity and insulin sensitivity, predominantly manifested in skeletal muscle as insulin resistance. t2dm is associated with increased morbidity and mortality. the disease is triggered by the individual lifestyle, and thereby the potential for prevention and reversal of the disease in its early years after diagnosis is quite large. one potential way to improve glucose homeostasis is by intermittent fasting, also known as alternate day fasting. intermittent fasting means switching between eating and fasting, and it is a variation of calorie restriction. intermittent fasting has been studied in animals. together with calorie restriction, intermittent fasting is the most efficient way to expand lifespan of many animal species without genetically altering them. a wide range of age related changes are delayed including beneficial effects on hypertension, degenerative brain disease, immune responses, dna repair capacity and glucose homeostasis. fat redistribution with fat translocating from between the organs and the liver to the subcutis. little is known about intermittent fasting in humans. in 2005 the investigators experimentally tested this concept in young healthy males and found that 15 days of alternating days with fast and food intake increased insulin sensitivity by 16% without any changes in body weight. the explanation could be oscillations in cellular energy stores. skeletal muscle contains approximately 80% of the stored glycogen alone by virtue of the muscle mass. the liver has a higher glycogen concentration, but it is much smaller. a single prolonged (\>24 hrs) day of fasting may not decrease muscle glycogen, while the decrease in the liver is very fast. a muscle glycogen lowering effect of continued intermittent fasting would be expected, and experimentally indicated. the intermittent fasting method may appeal to some patients, who do not exercise, and the need for testing this intervention in patients with type 2 diabetes is obvious.

Eligibility criteria:
inclusion criteria: * bmi 28-35 * type 2 diabetes or metabolically healthy * diet or orally administered treatment for type 2 diabetes exclusion criteria: * regular physical activity * other diseases than type 2 diabetes * insulin treatment * alcohol abuse

Keywords: intermittent fasting alternate day fasting diabetes mellitus non-alcoholic fatty liver disease insulin sensitivity