Kornimate/medical-research-clean huggingface dataset:
empower-pulm (pulmonary outcomes in older adults empowered with movement to prevent obesity and weight regain)

Conditions: Obesity; Pulmonary Disease; Dyspnea

Summary: the purpose of this study is to improve the understanding of the effects of weight loss on the lungs in older adults. different types of tests to understand the effects of the empower interventions on lung function will be administered.

this is a randomized clinical trial of the effects of structured aerobic exercise and a sedentary behavior intervention during weight loss on respiratory function. site will enroll 150 older (65-85 years), obese (bmi=30-45 kg/m2), sedentary men and women from empower. empower is a 3-group design where participants will undergo a 9-month weight loss (wl) intervention (6-mo intensive phase and 3-mo reduced contact phase), followed by a 9-month self-managed follow-up phase with minimal contact. the diet element of the interventions is identical across groups, but groups differ by activity intervention: 1) moderate-intensity aerobic exercise (wl+ex); 2) intervening on sb (wl+sitless); or 3) (wl+ex+sitless)

Eligibility criteria:
inclusion criteria: * 65 -85 years of age * bmi = 30-45 kg/m2 * weight stable - no loss or gain (±5%) in past 6 months * sedentary * no contraindication for safe and optimal participation in exercise training * approved for participation by medical director exclusion criteria: * dependent on cane or walker * reported unintentional or intentional weight loss or gain of \>5% in past 6 months * participation in regular resistance training and/or \> 20 mins/day of aerobic exercise in past 6 months * osteroporosis (t-score \<2.3 on hip or spine scan); severe arthritis, or other musculoskeletal disorder; joint replacement or other orthopedic surgery in past 6 mos; joint replacement or other orthopedic surgery planned in next 2 years * uncontrolled resting hypertension (\>160/90 mmhg); * current or recent past (within 1 year) severe symptomatic heart disease, uncontrolled angina, stroke, chronic respiratory disease other than asthma or copd, any disease requiring oxygen use, neurological or hematological disease,; cancer requiring treatment in past year, except non-melanoma skin cancers * serious conduction disorder, new q waves or st-segment depression (\>3mm), or uncontrolled arrhythmia * room air spo2 (oxygen saturation) at rest or with exercise qualifying for supplementary oxygen (spo2≤88%) * abnormal kidney or liver function (2x upper limit of normal); * efgr \< ml/min/1.73m2 * anemia (hb\<14 g/dl in men/\<12.3 g/dl in women); * uncontrolled diabetes (fasting blood glucose \> 140 mg/dl); * deficient levels of vitamin d (25 hydroxyvitamin d level \<20mg/ml) in those not taking a vitamin d supplement * smoker (no nicotine in past yr) * no heavy alcohol use (\>14 drinks/week) * unstable severe depression * regular use of: growth hormones, oral steroids, weight loss medications\* or prescription osteoporosis medications\* * current participation in other research study

Keywords: exercise
effectiveness of standard emergency department psychiatric treatment associated with treatment delivery by a suicide prevention center

Conditions: Suicide Attempted

Summary: very few studies have proved the effectiveness of treatment for suicide attempt patients. our objective is to evaluate the addition of the resources of an suicide prevention centre to standard psychiatric treatment in the emergency department. consecutive suicide attempt patients in 2 emergency departments (multicenter study) were included after standard psychiatric treatment and referral. after written informed consent, psychological assessment (depression, suicide intention) was carried out after randomisation, control patients were given an information card describing the suicide prevention center (spc); experimental patients had a first meeting with a psychologist of the spc. to verify the hypothesis of a decrease in suicidal behaviors in the experimental group, an evaluation of these behaviors was carried out every month during a two year follow-up.

very few studies have proved the effectiveness of treatment for suicide attempt patients. our objective is to evaluate the addition of the resources of an existent suicide prevention centre to standard psychiatric treatment in the emergency department. consecutive suicide attempt (self poisoning) patients in 2 emergency departments (multicenter study) were included after standard psychiatric treatment and referral. after written informed consent, psychological assessment (depression, suicide intent scale/sis beck depression inventory, toronto ale, beck hopelessness sc, audit, mini, pdq 4) was carried out after randomisation, control patients were given an information card describing the suicide prevention center (spc); experimental patients had a first meeting with a psychologist of the spc. the number of subjects included should be 405 per group. to verify the hypothesis of a decrease in suicidal behaviors in the experimental group, an evaluation of these behaviors was carried out every month during a two year follow-up the frequency of subsequent suicidal behavior will be monitored by the scrutiny of the emergency dept records. death by suicide will be identified by the examination of information obtained from the national death statistics office (inserm).

Eligibility criteria:
inclusion criteria: * parasuicide by self-poisoning * glasgow score=15 * standard psychiatric treatment exclusion criteria: * no speaking french * committed inpatient

Keywords: suicide parasuicide prevention individual supportive psychotherapy
registry of patient with m. dupuytren and validation of the brief mhq

Conditions: Dupuytren Contracture; Collagen Shrinkage; CRF

Summary: the purpose of this study is the validation of the brief michigan hand questionnaire by patient with morbus dupuytren and to build up a register.

examination of the characteristics of patient with morbus dupuytren and the psychometric properties of the brief michigan hand questionnaire by this patients

Eligibility criteria:
inclusion criteria: * m.dupuytren, over 18y, able to speak and understand german exclusion criteria: * recurrence, pregnancy, incapable of contracting
project rap: family-based hiv prevention in the juvenile drug court

Conditions: HIV/AIDS

Summary: the purpose of this project is to compare the effect of a family-based hiv prevention program to the effect of an adolescent-only health promotion program on adolescent hiv risk and marijuana use among adolescents enrolled in the juvenile drug court (jdc) of the rhode island family court.

adolescents and parents admitted to our study receive either an adolescent-only health education program that focuses on general health risk behaviors related to hiv/aids, smoking, diet and exercise or one that focuses on family-based hiv/aids education through safe decision-making and control of one's emotions as well as parent-child interactions that are associated with dysregulated affect, subsequent parenting deficits and adolescent hiv risk behaviors.

Eligibility criteria:
inclusion criteria: * 13 to 18 years old; * male and female; * in rhode island family court - intake and juvenile drug court program; * english speaking exclusion criteria: * hiv infection (by self-report); * history of sex crimes, * current pregnancy

Keywords: adolescent hiv aids sexual risk family prevention juvenile drug court juvenile justice drug use marijuana
the use of artificial intelligence in the dental x-rays analysis

Conditions: Oral Health; Dental Caries; Periapical Diseases; Tooth Loss

Summary: this cross-sectional study aims to perform a population-based assessment of the incidence of decay, dental fillings, root canal fillings, endodontic lesions, implants, implant and dental abutment crowns, pontic crowns, and missing teeth, taking into account the location.

this cross-sectional study aims to perform a population-based assessment of the incidence of decay, dental fillings, root canal fillings, endodontic lesions, implants, implant and dental abutment crowns, pontic crowns, and missing teeth, considering the location. patients with indications for dental x-ray confirmed by a written referral and with permanent dentition will participate in the study. then, the x-rays will be analyzed by the dentists and the ai-based software after the data has been anonymized. the results will be compared to determine the ai algorithm's sensitivity, specificity, and precision.

Eligibility criteria:
inclusion criteria: * indications for dental x-ray confirmed by a written referral from the dentist or physician (both screening tests and tests performed for treatment purposes were allowed) * permanent dentition (after exfoliation is completed) exclusion criteria: * patients with mixed dentition (exfoliation has not finished)
trial of leptin replacement therapy in patients with lipodystrophy

Conditions: Hypoleptinemia; Generalized Lipodystrophy; Partial Lipodystrophy; Insulin Resistance

Summary: lipodystrophies represent a therapeutic challenge with regards to insulin resistance, hypertriglyceridemia and fatty liver which often is coupled with significant adipose tissue loss. the purpose of the study is to examine the safety and efficacy of leptin on subjects with lipodystrophy.

the mechanism by which leptin improves glucose and lipid control is not clear. we will examine the possible mechanisms of leptin action by studying the effects of leptin administration on food intake, insulin resistance, insulin secretory response, hepatic and intramuscular triglyceride stores in a large sample of patients with lipodystrophy. hypothesis: leptin replacement in patients with generalized and partial lipodystrophy and hypoleptinemia will be safe and efficacious in improving the metabolic abnormalities associated with insulin resistance.

Eligibility criteria:
inclusion criteria: * age \> 6 years * partial and generalized lipodystrophy * serum leptin levels less than the 7th percentile of normal values reported by the 3rd national health and nutrition examination survey (less than 7.0 ng/ml in females and less than 3/0 ng/ml in males) * presence of at least one of the following metabolic abnormalities: 1. type 2 diabetes mellitus 2. fasting serum insulin \>20 uu/ml 3. fasting serum triglycerides \> 300 mg/dl 4. previous participation in leptin trial (amgen 991265, gcrc 660) - for part b of the study. exclusion criteria: * known liver disease due to causes other than non-alcoholic steatohepatitis. * hematocrit of less than 30%. * current alcohol or substance abuse. * use of anorexigenic drugs, anabolic steroids, gh and thiazolidinediones * active tuberculosis * psychiatric disorder impeding competence or compliance * malignancies * hiv infection * subjects who have a known hypersensitivity to e. coli derived proteins * other condition, which in the opinion of the clinical investigators would impede completion of the study.

Keywords: lipodystrophy insulin secretory response
a new multimodal treatment approach for children with spastic diplegic cerebral palsy

Conditions: Spastic Diplegic Cerebral Palsy

Summary: combining the advantages of both neuromuscular electrical stimulation and lower limb serial casting to a selected physical therapy program in children with spastic diplegic cerebral palsy to overcome the adverse effects during the period of casting and the long period of rehabilitative interventions, providing a new multimodal treatment approach.


Eligibility criteria:
inclusion criteria: * the children will have grade 2 or 3 on modified ashworth scale. * the children will have level ii, or iii according to the gross motor function classification system. * the children walk with equinus or jump gait patterns with spasticity of the hamstrings and hip flexors in addition to calf muscles spasticity. * children take their antispastic drug use such as baclofen, diazepam or tizanidine. * all children will be able to follow instructions. exclusion criteria: * children will be excluded from the study if they have any problems of the following: * cognitive dysfunction. * poor skin integrity. * history of or recent nonunion fracture. * fixed contractures and deformities. * previous surgery (tendon lengthening). * received botulinum toxin a injections in the last six months. * impaired circulation.

Keywords: diplegia, neuromuscular electrical stimulation, casting.
umbilical cord mesenchymal stem cells transplantation combined with plasma exchange for patients with liver failure

Conditions: Liver Failure

Summary: liver failure (lf) is a dramatic clinical syndrome with massive necrosis of liver cells. although liver transplantation provides an option to cure patients suffering with lf, lack of donors, postoperative complications, especially rejection, and high cost limit its application. previous study showed that bone marrow derived mesenchymal stem cells (bm-mscs) the novel and promising therapeutic strategy, bm-mscs can replace hepatocytes in injured liver, and effectively rescue experimental liver failure and contribute to liver regeneration. plasma exchange (pe) can improve internal environment by removing endotoxin, it helps the liver regeneration and functional recovery and make uc-msc differentiation into hepatocyte like cells, and exert immunomodulatory function. in this study, safety and efficacy of human umbilical cord mesenchymal stem cells (uc-mscs) transplantation combined with plasma exchange (pe) for patients with liver failure caused by hepatitis b virus will be evaluated.

to investigate safety and efficacy of human umbilical cord mesenchymal stem cells (uc-mscs) transplantation combined with plasma exchange (pe) for patients with liver failure caused by hepatitis b virus.

Eligibility criteria:
inclusion criteria: * written informed consent * acute-on-chronic liver failure caused by hepatitis b virus * model for end-stage liver disease (meld) \<30 exclusion criteria: * liver failure caused by other reasons, such as autoimmune diseases, alcohol, drug and so on * history of severe hepatic encephalopathy or variceal bleeding during the last two months before enrollment * severe problems in other vital organs(e.g. the heart, renal or lungs) * severe bacteria infection * tumor on ultrasonography, ct or mri examination * pregnant or lactating women

Keywords: mesenchymal stem cells plasma exchange liver failure hepatitis b virus
a study to evaluate ustekinumab in patients with plaque psoriasis in asia-pacific countries

Conditions: Plaque Psoriasis

Summary: the purpose of this study is to determine how patients use ustekinumab (label-recommended or other/missed dose interval) in asia-pacific countries.

this is an open-label (all people know the identity of the medication), multicenter, phase 4, observational study (no study medication was administered during the study) designed to assess how patients will use ustekinumab (label-recommended or other/missed dose interval) in asia-pacific countries. the study will consist of 4 study visits which will take place over the duration of 1 year. at the first visit (ie, week 0), eligibility for the study will be determined (it will be screening and baseline visit). at each subsequent visit (weeks 16, 28, and 52), exposure to ustekinumab will be recorded, questionnaires for efficacy will be completed, and information about adverse events and concomitant medications will be collected. as many patient reported outcome questionnaires as possible will be administered, depending on the availability of validated translations. safety will be assessed by monitoring of adverse events, vital signs and physical examination.

Eligibility criteria:
inclusion criteria: * have a diagnosis of plaque psoriasis, according to the dermatologists' clinical judgment * agree to initiate treatment with ustekinumab on the same day as enrollment into the study * have not received anti-il12/23 therapies within 6 months prior to enrollment into the study exclusion criteria: * has difficulty understanding questions posed by any of the questionnaires * are currently participating in an investigational drug clinical study

Keywords: plaque psoriasis ustekinumab cnto 1275 asia-pacific
effects of long term calorie restriction on sphingomyelin and amino acids

Conditions: Overweight; Obese

Summary: the effect of weight loss with long-term low calorie diet (lcd) on plasma metabolites is unknown. the aim was to examine whether a lcd-induced weight reduction results in changes in the extended plasma metabolites.

overweight/obese subjects (25≤ bmi \<33 kg/m2) aged 40 to 59 years consumed a lcd (an approximate 100 kcal/day calorie deficit) or a weight-maintenance diet (control) in a randomized, controlled design with 3-year intervention period.

Eligibility criteria:
inclusion criteria: * 25 \<= bmi \< 33 kg/m2 exclusion criteria: * type 2 diabetes * cardiovascular disease * psychiatric problems * any medication use

Keywords: low calorie diet bmi sphingomyelin l-leucine l-phenylalanine
benefits of the xiaxi postural hammock and a xiaxi exercise program

Conditions: Chronic Pain; Low Back Pain; Exercise

Summary: chronic low back pain is one of the main causes of pain, dysfunction and disability worldwide. in spain, 93% of the population has had back pain in the last year, and it is estimated that 50% of sick leave is due to this cause. this entails a great socioeconomic burden, since it is the main cause of absenteeism from work and the excessive use of therapeutic services. musculoskeletal disorders are related and associated with psychologically stressful jobs, that is, with psychosocial factors at work and related work stressors, such as time pressure, low job control, poor social or supervisor support, effort-reward imbalance or work-life conflict. clinical management of both situations encompasses a variety of approaches, including medication and early physical exercise, which have shown promise in reducing pain and improving function. a novel approach to address these problems is the use of xiaxi, a patented postural hammock with multiple angles of inclination that promotes relaxation and elongation of the posterior chain, thereby improving overall well-being. combining the use of xiaxi with a comprehensive program of strengthening, stretching and relaxation exercises could offer benefits in the prevention and reduction of back pain.


Eligibility criteria:
inclusion criteria: * age \> 18 years. * presence of back pain. exclusion criteria: * have undergone surgery of the spine, ischiosural muscles, psoas-iliac, pectoral and rotator cuff. * to have any structured spinal spine alteration diagnosed by health personnel. * have had a rupture of the ischiosural, psoas-iliac, pectoral and rotator cuff muscles in the last year or during the intervention. * have any type of injury that prevents you from performing the initial assessment in the first week of the procedure. * to have practiced vigorous physical exercise on the day of the investigation or 24 hours before the initial or final assessment. * having eaten large meals on the days of the investigation * less than two hours had elapsed since any prolonged recumbent rest at the start of the assessment.
licorice and home blood pressure, additional study

Conditions: Hypertension,Essential

Summary: out-of-office blood pressure is more strongly associated with cardiovascular risk than office blood pressure. licorice is known to raise blood pressure, but no previous studies have measured the effects on home blood pressure. the aim of this study is to analyze the association between licorice intake and home blood pressure.

for a detailed background, please see clinical trials registration number nct05661721. in brief, out-of-office blood pressure is more strongly associated with cardiovascular risk than office blood pressure. licorice is known to raise blood pressure, but no previous studies have measured the effects on home blood pressure. in a previous study, the response to licorice intake varied between participants. the aim of this study is to analyze the response of the most "licorice sensitive" quartile of participants from the original study to lower dosages of licorice, corresponding to 20 and 50 milligram och ga daily.

Eligibility criteria:
inclusion criteria: * previous participation in the licorice and home blood pressure study (nct05661721). exclusion criteria: * known hypertension, cardiovascular disease, kidney disease, liver disease, hormonal disease, peanut allergy, eating disorder or headache disease (including tension headache and migraine) * known alcohol abuse or drug abuse (including cannabis and anabolic steroids) treatment with hormonal drugs (including oral contraceptives * known intolerance to licorice intake.
the short-term effect of a technology driven weight control (smart) program for obese adults

Conditions: Obesity; Hypertension

Summary: the purpose of this study is to evaluate the short-term effect of a technology based weight reduction program for obese (bmi \> 30 kg/m2) adults in a primary care office.


Eligibility criteria:
inclusion criteria: 1. participant between the ages of 18-65 years. 2. participant with a bmi (body mass index \> 30.0 kg/m2) 3. have access and use email a minimum of 2-days per week. exclusion criteria: 1. participant is not pregnant or lactating: weight loss is not recommended for pregnant women and extra energy requirements are essential for fetal development (butte, wong, treuth, ellis, \& o'brian smith, 2004; durnin, 1991). 2. participant is not currently participating in any structured/self-help weight loss program. the elimination of individuals actively participating in a current weight loss program will reduce the potential of a carry-over effect from these weight loss modalities (fife-shaw, 2006). 3. participant has not attempted weight loss in the past 3 months. same as number two.
influence of intra-canal cryotherapy on post-endodontic pain and interleukin-6 expression using different irrigation protocols: a randomized clinical trial

Conditions: Symptomatic Periapical Periodontitis

Summary: the study was to evaluate the effect of intra-canal cryotherapy on post-endodontic pain and interleukin-6 expression in teeth with symptomatic apical periodontitis using different irrigation protocols.


Eligibility criteria:
inclusion criteria: * anterior or premolar single canal in single rooted teeth. * patients aged 20 to 50 years. exclusion criteria: * patients under anti-inflammatory medication, immune-suppressive chemotherapy or any antibiotic medication for the last 2 months. * pregnant or lactating females. * teeth with endo-perio lesions.

Keywords: cryotherapy interleukins postoperative pain sodium hypochlorite