Kornimate/medical-research-clean huggingface dataset:
variation of comt val158met polymorphism between com-on patients and methadose patients

Conditions: Opioid-related Disorders; Opiate Dependence; Opiate Addiction; Opiate Abuse

Summary: the main objective is to compare the genotypes of the comt val158met polymorphism between opiate-users and opiate-dependent subjects. the secondary objective is to constitute a sample of opiate-users without any lifetime opiate dependence.

the comt enzyme enables the degradation of brain monoamines such as dopamine and is encoded by a single gene for which several polymorphisms are known, including the val158met polymorphism which has been widely studied in various psychiatric disorders, including addictions, as well as in impulsivity. in most studies it is the val allele which is found to be associated with addictive behaviors. the study methadose, which began in 2009, includes opiate-dependent patients substituted by methadone. the preliminary analysis of this study shows a genotype distribution different from that of general population samples, with a greater prevalence of val / val and val / met genotypes. will be included in the com on study subjects who have consumed illicit opiates (heroin, methadone, buprenorphine or morphine) more than 10 times in their life, without ever having the dsm-iv criteria for opiate dependence or abuse. the study will compare, by means of saliva samples, val / val and val / met genotypes between the subjects recruited in com on and those recruited in methadose. will also be included auto-questionnaires to identify psychological factors that may constitute risk or protective factors vis-à-vis the development of dependence.

Eligibility criteria:
inclusion criteria: * patient over 18 years old * caucasian patients * clinical diagnosis of lifetime opiate-using disorder (consumption over 10 times of illicit opiates (heroin, buprenorphine, methadone or morphine)) * not lifetime history of opioid dependence (dsmiv) * patients with health insurance coverage * patient was treated with opioids analgesics to alleviate 2 or 3 in their lives exclusion criteria: * non-caucasian patients * patients who cannot give their consent and/or who refuse the collection of genetic data * patients with no health insurance coverage

Keywords: cross-sectional observational study comt polymorphism opiate-users opiate dependence
diagnosis and treatment strategies in patients with nsclc with or without egfr mutations.

Conditions: Stage IIIB/IV; Non-Small Cell Lung Cancer

Summary: the purpose of this trial is to compare the evolution of patients receiving first line treatment for locally advanced or metastatic lung cancer, taking into account if they were requested or not the egfr mutation test as part of the diagnosis and treatment strategy. there is no assignment to any particular therapeutic strategy.

study of cases and controls on diagnosis and treatment strategies in patients with nsclc with or without egfr mutations.

Eligibility criteria:
inclusion criteria: * patients with confirmed diagnosis of lung adenocarcinoma, stage iiib/iv. * patients under 1st line treatment against lung adenocarcinoma. exclusion criteria: * patients not having the information required by the protocol.

Keywords: non-small cell lung cancer, epidermal growth factor receptor mutation, lung cancer, lung adenocarcinoma
the surveillance of hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: early detection of hepatocellular carcinoma is vita to the prognosis of patient. in this study, the occurrence and development of liver cancer were supervised by imaging examination, and the dysplastic nodules will be distinguished from early hepatocellular carcinoma through macro-imaging and micro-pathological features.


Eligibility criteria:
inclusion criteria: - patients with hepatitis b and cirrhosis accept regular imaging examination. pathological diagnosis of liver cancer. exclusion criteria: - can't tolerate the enhanced imaging examination poor medical compliance
prevalence of flexor hallucis longus tears, associated os trigonum excision, and return to play

Conditions: Ankle Impingement; Tendon Tear

Summary: the study's aim is to determine the incidence of flexor hallucis tendon tears associated with os trigonum excision. the study will then compare the length until functional return to play of the patients who had flexor hallucis tendon tears with concomitant os trigonum excision versus those without flexor hallucis tendon tears who underwent os trigonum excision. lastly, the study will be evaluating the patient complaints and physical exam findings before and after surgery and compare those without flexor hallucis tendon tears to those with flexor hallucis tendon repair.

posterior ankle pain syndrome has many etiologies. two main causes of this are flexor hallucis tendon tear and os trigonum impingement. the current teaching is that patients with flexor hallucis longus tear complain of posterior medial ankle pain and those with posterior lateral ankle pain have an os trigonum impingement. it is also classically understood that patients with flexor hallucis tendon tears take longer to return to their pre-injury level of function. our clinical experience refutes these reports and our study looks to further evaluate it. this study brings back patients who were treated by the study doctor. the patient's preoperative evaluation will be reviewed including clinic notes and imaging. the operative reports for these patients will be reviewed to verify the surgery procedure performed. these patients will be included in the study and we will utilize the american academy of orthopedic surgeons foot, ankle, and lower limb module that they have completed postoperatively. this measure of patient's functional and subjective satisfaction has already been completed by patients at their regularly scheduled follow up appointments and is available for review. prospectively, patients will be asked to return to the clinic for a follow-up evaluation, which includes a standard x-ray. all patients will be consented prior to data collection, minors included in this study will be asked to sign an assent as well. many factors will be assessed such as; a range of motion test of the ankle utilizing goniometric technique, nerve path and function, stability ankle grading, radiologic findings, and patient-reported outcomes filled out pre and postoperatively.

Eligibility criteria:
inclusion criteria: * os trigonum excision with or without a flexor hallucis longus tear in an athletic population (recreational to competitive) * males and females ages 11-50 at time of surgery exclusion criteria: * any other injury that will affect their return to play or recovery process * individuals not actively involved in athletic sport/activity * pregnant women * any other concomitant injuries

Keywords: flexor hallucis longus os trigonum return to play
fingolimod real world experience: the french grand-est cohort

Conditions: Multiple Sclerosis

Summary: objectives: this study describes efficacy and safety of fingolimod in patients treated for at least 6 months in the east of france from january 2011 to december 2014. background: the grand-est is a geographical region in france with a high prevalence of multiple sclerosis (more than 10000 patients registered in the european database for multiple sclerosis (edmus) database). in this region and since january 2011, more than 1014 patients have been treated for at least 6 months with fingolimod, the first oral therapy for patient with very active relapsing-remitting ms. methods: features of patients followed up in the grand-est region and treated with fingolimod in the 6 university hospitals, general hospitals and private neurologists were reviewed in a retrospective study after identification of the clinical files reported in the edmus database.


Eligibility criteria:
inclusion criteria: * patients with ms treated with gilenya because of the disease exclusion criteria: * contraindications of gilenya treatment or receiving gilenya after the 31st of march 2014
denture adhesive is a patient advantageous or prosthetic failure during adaption period: randomized control

Conditions: Dental

Summary: introduction: the complete denture wearers mainly complain of decrease of denture retention which affects on patient's quality of life objective: to evaluate oral health-related quality of life (ohrqol) of denture adhesive for completely edentulous denture wearers. material and methods : 32 patients(new denture wearers) were selected form prosthdontic clinic in three dental faculties in various region in egypt, there were 22 females (68%) and 10 males (46%) were distributed in two groups: conventional group without adhesive and adhesive group with adhesive application n = 16;, in a cross over study. evaluation by oral health impact profile in edentulous adults (ohip-edent) inventory at 1, 2 and 3 months after the insertion of new complete dentures. data were analyzed using 2-way anova test and generalized estimating equations (gees), α = 0.05.

32 patients(new denture wearers) were selected form prosthdontic clinic in three dental faculties in various region in egypt, there were 22 females (68%) and 10 males (46%) were distributed in two groups: conventional group without adhesive and adhesive group with adhesive application n = 16;, in a cross over study. evaluation by oral health impact profile in edentulous adults (ohip-edent) inventory at 1, 2 and 3 months after the insertion of new complete dentures. data were analyzed using 2-way anova test and generalized estimating equations (gees), α = 0.05.

Eligibility criteria:
inclusion criteria: * completely edentulous exclusion criteria: * no

Keywords: denture adhesives, quality of life and ohip-edent
the impact of artificial intelligence electrocardiography on occlusion myocardial infarction management under the value-based payment system

Conditions: OMI - Occlusion Myocardial Infarction; Artificial Intelligence (AI); Electrocardiogram; Cost-effectiveness Analysis

Summary: this trial will prospectively evaluate the impact of integrating ai-ecg within the pay-for-performance program on improving the diagnosis, treatment, and clinical outcomes of occlusion myocardial infarction patients by promoting accurate and timely diagnoses through financial incentives.

the investigators have developed an ai-ecg system that provides real-time notifications for patients with potential occlusion myocardial infarction. this ai algorithm is seamlessly integrated into the hospital information system, allowing for the automatic generation of reports whenever an ecg is performed. the purpose of this study is to evaluate the impact of ai-ecg on the timely diagnosis of stemi, including patients' outcomes and healthcare costs.

Eligibility criteria:
inclusion criteria: * patients in the emergency department * patients received at least 1 ecg examination. exclusion criteria: * the patients received ecg at the period of inactive ai-ecg system. * patients with a history of coronary angiography within the past 3 days.
rct of evening primrose oil for the treatment of breastfeeding pain

Conditions: Breast Feeding

Summary: breastfeeding related mastalgia is a common post-partum complaint. we propose a double-blind, randomized, placebo-controlled trial that investigates the use of evening primrose oil in the treatment of breastfeeding related mastalgia.


Eligibility criteria:
inclusion criteria: * currently breastfeeding * recent delivery within the trailing 60 days exclusion criteria: * history of seizure disorder
intra testicular artery injection of bone marrow stem cell in management of azoospermia

Conditions: Azoospermia

Summary: azoospermia due to low sperm production (non-obstructive azoospermia) affects approximately 1% of the male population and 10% of men who seek fertility evaluation. testis biopsy reveals that these men have sertoli cell-only pattern, maturation arrest, or hypospermatogenesis. until recently, it was assumed that men with non-obstructive azoospermia were untreatable. indeed, these patients were often referred to as being "sterile" or having "testicular failure." we start to use stem cell in treatment of such patients by injecting the stem cell at the testis and the testicular artery in one group and at the testis only in other group


Eligibility criteria:
inclusion criteria: - azoospermia exclusion criteria: - absent or surgical removed testes

Keywords: stem cell, infertility, azoospermia
effect of mindfulness-based stress reduction intervention on psychological distress and hope among female patients undergoing radiotherapy for breast cancer

Conditions: Breast Cancer Female

Summary: breast cancer is a significant issue in egypt, affecting a large number of women and impacting their psychological well-being. younger patients and those undergoing adjuvant therapy or radiotherapy are particularly susceptible to psychological distress. psychological counseling and support groups can help improve patients' quality of life and social functioning. hope plays a crucial role in the treatment process, as it is associated with positive outcomes and serves as a protective mechanism against stress and disease. mindfulness-based stress reduction (mbsr) is an intervention that can reduce stress and depression in cancer patients. it involves cultivating awareness of the present moment and has positive effects on quality of life. investigating the impact of mbsr on psychological distress and hope in women undergoing radiotherapy for breast cancer is important for providing effective support during treatment. the aim of this study is to: examine the effect of the mindfulness-based stress reduction intervention on psychological distress and hope among female patients undergoing radiotherapy for breast cancer. research hypothesis female patients undergoing radiotherapy for breast cancer who attend mindfulness-based stress reduction intervention sessions exhibit higher levels of hope and lower levels of psychological distress compared to those who receive conventional hospital treatment.


Eligibility criteria:
inclusion criteria: * adult female patients with post-mastectomy (within one to six months). * able to communicate verbally. * able to read and write. * willing to participate in the study. exclusion criteria: * other associated diseases such as (renal disease, ischemic heart disease, liver disease) will e excluded.

Keywords: mindfulness-based stress reduction psychological distress hope female patients radiotherapy breast cancer
an intervention in a primary healthcare setting to reduce lyme neuroborreliosis treatment delay

Conditions: Lyme Neuroborreliosis

Summary: this study evaluates the effect of written and oral information in a primary health care setting on 1) patients referred to specialised examination for lyme neuroborreliosis, 2) delay from patient symptom debut to treatment for lyme neuroborreliosis, and 3) number of borrelia serology tests from primary health care.

lyme neuroborreliosis is among the most common neuroinfections in northern europe. residual symptoms after treatment are a frequent problem in lyme neuroborreliosis, and an association between the delay from symptom debut to antibiotic treatment has been established. in a previous study on funen island, denmark, the delay from day of symptom debut to treatment for lyme neuroborreliosis patients was 24 days. this considerable treatment delay did not change in the 20 years study period. in the danish health system, the general practitioners are the first medical professionals to see the majority of patients. they can refer patients to the hospital for further examination if indicated. many general practitioners use borrelia burgdorferi antibodies (igm/igg) as a screening tool when they suspect lyme disease or see patients with uncharacteristic symptoms. this is unfortunate, as the rash erythema migrans, the most common borreliosis manifestation in europe, is a clinical diagnosis. only around 50% of patients have positive antibodies at time of erythema migrans diagnosis. lyme neuroborreliosis is diagnosed based on symptoms and the results from the cerebrospinal fluid, and cannot be diagnosed based on serology, which only delays the time to diagnoses and treatment. the danish guidelines on lyme borreliosis therefore discourage general practitioners from using borrelia serology. in the before mentioned study from funen island, several patients described multiple contacts to their general practitioners, where the symptoms of lyme neuroborreliosis were not recognized. the cardinal symptom of radicular pain was associated with a longer delay than many of the less common symptoms of lyme neuroborreliosis.

Eligibility criteria:
inclusion criteria: * primary care physicians with a postal code in an area of funen island with a lyme neuroborreliosis incidens of \> 4.6/100.000 * patients with a postal address on funen and a positive borrelia intrathecal antibody test (diagnostic for lyme neuroborreliosis) performed at the department of clinical microbiology, odense university hospital from january 1st 2017 - december 31st 2020 * a borrelia igm/igg serology ordered from primary health care and performed at the department of clinical microbiology, odense university hospital from january 1st 2017 - december 31st 2020 exclusion criteria: * primary care physicians with a postal code in an area of funen island with a lyme neuroborreliosis incidens of \< 4.7/100.000

Keywords: treatment delay primary health care
job adaptation in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the specific aim of this study is to compare the rate of negative work role events in individuals with rheumatoid arthritis compared to healthy controls.

rheumatoid arthritis can cause multiple socio-medical disabilities, with work disability among the most marked. while a major focus has been documenting the rates of job loss and returning patients to the workforce, there is little information about how to foster job retention in those still employed. the goals of this study are to document negative workplace events over 1 year in 122 employed patients with rheumatoid arthritis, and to compare these to 122 healthy controls, who are included to account for the effects of socioeconomic status on employment. events will be recorded with the work domain of the psychiatric epidemiology research life events scale. additional goals are to compared fatigue, physical activity, functional status and sleep disturbances as covariates.

Eligibility criteria:
inclusion criteria: * patients are eligible if they are: * over age 18; * meet american rheumatism association criteria for rheumatoid arthritis; and * are employed for salary or monetary reimbursement. * controls are eligible if they are: * over age 18; * have no major comorbidity; and * are employed for salary or monetary reimbursement. exclusion criteria: * patients and controls are excluded if they: * have cognitive deficits and cannot provide informed consent; * do not speak english or spanish; or * their physicians do not grant permission to enroll them.

Keywords: employment negative workplace events healthy controls fatigue physical activity
adjuvant therapy in pole-mutated and p53-wildtype/nsmp early stage endometrial cancer rainbo blue & taper

Conditions: Endometrial Cancer

Summary: this protocol tests de-escalated adjuvant treatment in patients with pole-mutated or p53wt/nsmp (p53 wildtype/no specific molecular profile) early-stage endometrial cancer (ec). patients may be enrolled in one of two sub-studies * en10.a/rainbo blue: pole-mutated ec * en10.b/taper: p53 wildtype / nsmp ec

this study is being done in order to find out if this new approach is better or worse than the usual approach for early-stage endometrial cancer. the usual approach is defined as the care most people get for early-stage endometrial cancer. the usual approach for patients who are not in a study is treatment with surgery. tissue that is removed as part of this procedure is analyzed in the pathology laboratory to guide the doctor to decide whether or not additional treatment such as radiation and or chemotherapy should be recommended.

Eligibility criteria:
inclusion criteria: * patients must have had surgery consisting of hysterectomy and bilateral salpingo-oophorectomy. lymph node dissection can be performed as per institutional standards. there must be no macroscopic residual disease after surgery. * patients must have histologically confirmed stage i to iii endometrial carcinoma which can be endometrioid, serous, clear cell, un/dedifferentiated, carcinosarcoma or mixed. * patients' eastern cooperative group (ecog) performance status must be 0, 1, or 2. * hiv-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial. * patients' age must be ≥ 18 years. * patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements. * patient is able (i.e. sufficiently fluent) and willing to complete the patient-reported outcomes (pro) questionnaires in either english, french or a validated language * patients must be accessible for treatment and follow-up. patients enrolled on this trial must be treated and followed at the participating centre * protocol treatment is to begin within 10 weeks of hysterectomy/bilateral salpingo-oophorectomy exclusion criteria: * prior neoadjuvant chemotherapy for current endometrial cancer diagnosis. * prior pelvic radiation. * patients with a history of other malignancies, except: carcinoma in-situ without evidence of invasive disease when resected, adequately treated non-melanoma skin cancer, or other tumours curatively treated with no evidence of disease for ≥ 5 years. * clinical evidence of distant metastasis as determined by pre-surgical or post-surgical imaging (ct scan of chest, abdomen and pelvis or whole-body pet-ct scan) * patients with a documented positive surgical margin. * patients with a documented positive peritoneal washings, if performed.