Kornimate/medical-research-clean huggingface dataset:
a school-based osteoporosis prevention program for adolescent girls

Conditions: Osteoporosis

Summary: the incorporating more physical activity and calcium in teens (impact) study was a behaviorally-based middle school nutrition and physical activity program for the prevention of osteoporosis. the goal of impact was to increase calcium intake and physical activity to help build bone mass in girls.

peak bone mass is achieved during the first twenty years of life, and dietary and activity patterns that contribute to the formation of peak bone mass are developed during childhood. the impact intervention was designed to increase bone density and ultimately prevent osteoporosis during adulthood. impact included physical education, food service, and classroom environmental and behavioral components and was delivered by physical education (pe) specialists, food service personnel, and classroom teachers. a group of 718 sixth grade girls (mean age 11.1) from twelve middle schools in central texas participated in the study. the group was 72% non-hispanic white, 12% hispanic, 5% african american, and 11% other ethnicity. after baseline measurements were completed in the fall of 2000, the twelve middle schools were pair-matched based on school characteristics (ethnicity, % economically disadvantaged, % girls in athletics) to a control (usual health education program) or the impact program. the intervention was implemented for 18 months and consisted of three major components: a pe component, which emphasized daily weight-bearing activities (wba); a health lessons component consisting of sixteen behaviorally-based lessons which emphasized wba, calcium-rich foods, and osteoporosis prevention; and a food service component. outcome measures included physical properties of the students' heel bones, calcium consumption, physical activity, and psychosocial factors believed to be precursors to these behaviors. changes at the school environmental level, such as the number of calcium rich foods offered in the cafeteria and the number of opportunities offered for weight-bearing and aerobic activity, were also assessed.

Eligibility criteria:
inclusion criteria: * girls enrolled in 6th grade of selected schools * student assent * parental consent * no fractures or medications that compromise bone health or strength * enrolled in 2 semesters of physical education

Keywords: weight-bearing physical activity calcium intake school-based health education adolescent girls child nutrition diet
delay to diagnosis in digestive cancerology by the general practitioner related to covid-19 pandemic confinement

Conditions: Neoplasms, Colorectal; General Practitioner; Pandemic, COVID-19; Neoplasm, Liver; Neoplasms Pancreatic; Diagnosis; Advanced Cancer

Summary: objective: the pre-hospital management of cancers is little known in general medicine. the first lockdown related to the covid-19 pandemic led to the closure of health facilities. investigators were interested in the diagnosis and care pathway of digestive cancers in post-confinement in general medicine in nouvelle-aquitaine.

method: patient records discussed in digestive oncology cpr of bordeaux university hospital for the first time from june 1 to august 31, 2020 and over the same period in 2019 were included. a questionnaire on the dates of the first symptoms, first consultation with the general practitioner, imaging examination and access to the specialist was sent to the general practitioner. the primary outcome was time from onset to date of first mdt.

Eligibility criteria:
inclusion criteria: * residing in new aquitaine and * whose general practitioner practiced in new aquitaine * malignant tumors of the esophagus, stomach, small intestine, colon, recto-sigmoid junction, rectum, anus and anal canal, liver and intrahepatic bile ducts, extrahepatic bile ducts, gallbladder and pancreas. * to have had at least one consultation or hospitalization in the digestive pole of the bordeaux university hospital within 6 months after the mdt. exclusion criteria: * patients under 18 years of age, * who had already had a mdt for this cancer, * whose date of first mdt was outside the inclusion dates, * whose new cancer was a digestive metastasis of a primary of another location, * who did not have french health insurance

Keywords: digestive cancer, covid
mitraclip system in australia and new zealand

Conditions: Mitral Regurgitation

Summary: the primary objective of the mitraclip system australia and new zealand (anz) clinical trial is to gather real-world clinical and health-economic outcome data to support the long-term safety, efficacy and economic value of the mitraclip system in the continuum of therapies for treating mr. specifically, the following clinical and economic data will be collected: new york heart association (nyha) functional class, six-minute walk test (6mwt) distance, quality of life (qol) information, echocardiographic measures of left ventricular size and function, and data associated with the index hospitalization, rehospitalizations, concomitant medications and discharge facility to support the mitraclip system economic analysis.

the mitraclip system anz clinical trial is a prospective, observational, single arm, multicenter trial to evaluate the mitraclip device for the treatment of mitral regurgitation (mr). patients will be enrolled at up to 15 investigational sites throughout australia and new zealand. up to 150 patients will be enrolled. patients will be considered enrolled when local or general anesthesia is administered for the mitraclip procedure. patients will be followed at discharge, 30 days, 6 months, 12 months and 24 months. investigational sites will recruit consecutive patients who meet trial enrollment criteria. until enrollment in the mitraclip system anz clinical trial is closed, all patients who undergo a procedure for placement of a mitraclip device at an investigational site should be enrolled in the mitraclip system anz clinical trial.

Eligibility criteria:
inclusion criteria: * age 18 years or older. * mr ≥ 3+ . * transseptal catheterization and femoral vein access feasible. * placement of the mitraclip device on mitral leaflets feasible. * mitral valve orifice area ≥ 4.0 cm2. * written informed consent obtained. * the patient agrees to return for follow-up visits. exclusion criteria: * need for emergency surgery, other cardiac surgery. * coronary artery disease (cad), atrial fibrillation (af), other valve disease. * prior mitral valve repair surgery, mechanical prosthetic valve, or ventricular assist device (vad). * active endocarditis or rheumatic heart disease; leaflets degenerated from endocarditis or rheumatic disease. * transesophageal echocardiography (tee) contraindicated. * known hypersensitivity or contraindication to trial or procedure medications which cannot be managed medically. * currently participating in investigational drug trial or another device trial that has not yet completed the primary endpoint or that interferes with the mitraclip system anz clinical trial. * pregnant or planning pregnancy within next 12 months.

Keywords: mitraclip mitral regurgitation (mr) mitral valve insufficiency percutaneous mitral valve repair congestive heart failure
preoxygenation method with a calibrated leak

Conditions: Preoxygenation; Non Invasive Ventilation

Summary: during preoxygenation, imperfect seal between the face mask and patient's face can induce an inward air leak decreasing its effectiveness. we assume that noninvasive ventilation could cancel the effect of the leak. this is a prospective study. healthy volunteers are randomised in cross-over between spontaneous breathing or noninvasive ventilation pressure support preoxygenation in the presence or absence of a calibrated leak on the inspiratory circuit.

during preoxygenation, imperfect seal between the face mask and patient's face can induce an inward air leak decreasing its effectiveness. we assume that noninvasive ventilation could cancel the effect of the leak. we planned an experimental study with healthy volunteers (residents in anesthesiology). healthy volunteers are randomised in cross-over between preoxygenation through spontaeous breathing or noninvasive ventilation pressure support preoxygenation in the presence or absence of a calibrated leak on the inspiratory circuit. the inspiratory fraction of oxygen is 100%. the exhaled gas (oxygen and carbon dioxide) are monitored.the subjects breathed through a mouthpiece (with a nose clip) connected to an anesthetic ventilator. the primary endpoint is the time to achieve end expiratory fraction of oxygene of 90% or more. the secondary endpoint is the proportion of subject with end expiratory fraction of oxygen of 90% or more after a 3 min period (recommended in clinical guidelines).

Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * any pathological condition * active tobaco
correlation between family functioning and psf

Conditions: Stroke

Summary: in the present study, the investigators investigate the effect of family functioning on psf in neurologic stroke patients in the early stages of the disease by surveying the current status of post-stroke fatigue to provide theoretical support for clinical care.


Eligibility criteria:
inclusion criteria: * patients whose clinical manifestations met the diagnostic criteria for stroke and whose stroke was confirmed by imaging (cranial computed tomography or cranial magnetic resonance imaging) * those with first-episode stroke and in a stable condition * those who were conscious and able to cooperate with the investigation * those who gave informed consent and volunteered to participate in the study exclusion criteria: * patients with severe aphasia * those with severe cognitive impairment who were unable to cooperate with examinations or questionnaires * those with malignant tumours * those with degenerative diseases of the central nervous system, such as parkinson's disease * those who were unable to cooperate with the doctor in the examination for other reasons * those with a previous history of mental illness * those with other recent major stressful life events, such as divorce or death of a loved one * those with pre-stroke fatigue (prsf)

Keywords: post-stroke fatigue family functioning
investigating barriers for decision making in a danish breast cancer screening context

Conditions: Breast Cancer Female; Mammography Screening; Decision Making; Information Seeking Behavior

Summary: the aim is to investigate potential barriers to informed decision making in a breast cancer screening context. this is a necessary step prior to developing and investigating improved information or decision aids in a danish breast cancer screening context.

in this study, preferences and attitudes towards breast cancer screening, invitation, and decision making among danish women will be investigated. the aim is to gain knowledge about barriers for (informed) decision making in a danish breast cancer screening context. the study will be conducted by sending out an online questionnaire to women aged 44-49 in denmark. the questionnaire will be sent out using the official digital mail system, e-boks, with an invitation, link, and login information to access the online questionnaire. the questionnaire will consist of background questions about the participants, questions related to the current information material and invitation to the danish breast cancer screening program, and questions about decision making and informed choice. women will be randomized to one of three questionnaires: 1) questionnaire with "stage of decision making" to investigate women's decision making process regarding participation in screening, 2) questionnaire with choice framing (presentation of a choice between participation in breast cancer screening or no screening), or 3) questionnaire with opportunity framing (only presentation of screening, no alternative) to investigate decision making process and impact of different framing. the main hypothesis for this study is that 80% of danish women have already made their decision about screening participation when presented to the opportunity framing and 70% when presented to the choice framing. 1000 women will be invited to each group in this study and thus 3000 in total, as this is the minimum number satisfying the requirements for both the main hypothesis and secondary aims (not described in detail here). no similar studies were found, therefore, this sample size calculation is based on proportions of 50% to have enough power in our study. with a desired standard error no larger than 2.5%, 400 women are required (se of a binomial random variable). assuming 40% participation, a study population of 1000 women in each group is required. next, questionnaire data will be linked to register data on sociodemographic factors from statistics denmark. the study is registered at aarhus university's internal records: 2016-051-000001, 2563.

Eligibility criteria:
inclusion criteria: * all women living in denmark in this age group exclusion criteria: * none
combined behavioral approaches with functional electrical therapy in stroke rehabilitation

Conditions: Cerebrovascular Accident

Summary: this project attempts to perform a randomized controlled trial to verify the efficacy and motor control mechanism of the proposed combined functional electrical therapy with distributed constraint-induced therapy or with robot-assisted bilateral training.

two theory-based, task-oriented approaches are distributed cit (dcit) and robot-assisted bilateral training(bat). cit/dcit involves massed practice of the affected arm and restraint of the unaffected arm. bat involves repetitive practice of symmetrical bilateral movements on robot. both are evident to improve motor performance, motor control or daily function in high functioning patients. these dcit and bat have their own limitations for motor-deficit rehabilitation after stroke, i.e. only appropriate for high-functioning or mildly motor impaired patients. functional electrical therapy, an innovative technology, is proposed as an adjunct to these behavioral approaches to assist in movement execution. functional electrical therapy is used to increase the electric activity of muscles for movement and the active range of motion in low functioning patients. combining functional electrical therapy into cit or bat may extend the utility of these two behavioral approaches beyond patients with mild motor deficits and could expedite the progress of motor recovery. this project attempts to perform a randomized controlled trial to verify the efficacy and motor control mechanism of the proposed combined functional electrical therapy with dcit or with bat.

Eligibility criteria:
inclusion criteria: * the onset duration more than 6 months * an initial upper extremity subsection of the fugl-meyer assessment score of 33 to 52 indicating moderate or moderate-to-mild movement impairment * no serious cognitive deficits (a score of more than 24 on the mini mental state exam) * the availability of caregiver for assistance during the 6-hour restraint time of unaffected extremity per day * no balance problems sufficient to compromise safety when wearing the project's constraint device with the assistance of the caregiver * considerable nonuse of the affected upper extremity (an aou score \< 2.5 of motor activity log) exclusion criteria: * exhibit physician determined major medical problems or poor physical conditions that would interfere with participation * excessive pain in any joint that might limit participation

Keywords: functional electrical therapy bilateral arm training constraint induced therapy stroke rehabilitation clinical evaluation kinematic analysis
treatment outcome and prognostic factors for rheumatoid arthritis (ra) patients with interstitial lung disease (ild)

Conditions: Rheumatoid Arthritis; Interstitial Lung Disease

Summary: the objectives of this single center, prospective, non-interventional cohort is to understand patient characteristics, general treatment patterns, effectiveness/safety of conventional disease modifying antirheumatic drug (dmard) and biologic dmard treatments in rheumatoid arthritis patients with ild in the real-world setting

primary objective : comparison of prognosis between ra-ild and ra-non ild patients secondary objectives 1. identification of the prognostic factors or aggravation factors of ild in ra-ild patients 2. identification of the association between ild and autoantibody profiles in ra-ild patients 3. comparison of ra disease activity control between ra-ild and ra-non ild patients using disease activity score (das)28-erythrocyte sedimentation ratio (esr), das28 c-reactive protein (crp), simple disease activity index (sdai) and clinical disease activity index (cdai) 4. comparison of biologic and non-biologic dmard treatment response in ra-ild patients using disease activity parameters the study population will be adult ra patients who have checked a chest computed tomography (ct) scan within 2 years of enrollment. no additional visits or laboratory tests will be done outside the routine clinical practice for ra-non ild patients. for ra-ild patients, high resolution computed tomography (hrct), pulmonary function test (pft) and 6-min walk test will be examined annually to identify the progression of ild. selection of medication including conventional dmards, biologic dmards, glucocorticoid, and inhaler, dosing and treatment duration are at the discretion of the investigator.

Eligibility criteria:
a. inclusion criteria: * patients who satisfy the 1987 american college of rheumatology (acr) or 2010 acr/eular classification criteria for ra adult patients * patients who are more than 19 years old * patients who have checked chest ct scanning within 2 years * patients who provide a written consent of participating in this study b. exclusion criteria: * patients who are aged under 19 years old * patients who are pregnant * patients who dose not provide a written consent of participating in this study
drug-eluting beads bronchial arterial chemoembolization in stage ii-iii non-small-cell lung cancer patients failed, refused or ineligible to receive standard treatments

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: this is a multicenter, prospective, single-arm clinical study to determine the efficacy and safety of drug-eluting beads bronchial arterial chemoembolization（deb-bace） in stage ii-iii nsclc patients who failed, refused or ineligible to receive standard treatments


Eligibility criteria:
inclusion criteria: 1. patients ≥ 18 years old, of any sex; 2. patients who have histopathological proof of nsclc according to the standard of diagnosis and treatment of primary lung cancer（v2018）; 3. confirmed tnm stage is ii-iii of nsclc; 4. patients who were failed, refused or assessed ineligible by mdt to receive conventional second-line treatments (surgery, chemoradiotherapy, targeted and immunotherapy)； 5. eastern cooperative oncology group (ecog) performance status (ps) score of 0-2; 6. life expectancy of \> 3 months; 7. patients volunteered to participate in this study and signed informed consent, with good compliance; exclusion criteria: 1. patients received interventional therapy (i seeds implantation, ablation, bace) before; 2. a history combined with other malignant tumors and not cured; 3. wbc\<3×109/l、lym\<1.5×109/l、nlr≥3、plt\<50×109/l、hgb\<90 g/l; 4. insufficient of liver and renal function (cr\>176.8 µmol/l; ast and/or alt\>2 folds of normal value)； 5. combined with uncorrectable coagulation dysfunction or active massive hemoptysis; 6. combined with active affection and need antibiotic treatment; 7. uncontrollable hypertension, diabetes, cardiovascular disease with obvious symptoms; 8. known to be hypersensitive to contrast agent; 9. pregnant or breastfeeding women;
improved treatment course for patients with migraine and tension-type headache

Conditions: Migraine; Tension-Type Headache

Summary: the purpose of the study is to improve treatment for newly referred patients with migraine and tension-type headache to the danish headache center. all patients will recieve an electronic questionnaire just before the first visit concerning their current and previous history of headache and headache treatment. half of them will enter a special telephone-intervention (teii) program with two planned phone-calls after 8 and 16 weeks from first visit. the other half of patients will follow the normal follow-up program. all patients will be seen by a headache specialist after 6 months and will be asked to fill in a follow-up electronic questionnaire.


Eligibility criteria:
inclusion criteria: * migraine and/or tension-type headache exclusion criteria: * other headache diagnoses, including cluster headache, medication overuse-headache, other secondary headaches, trigeminal neuralgia. * included in clinical trials at the dhc.
spaced retrieval as treatment for aphasia

Conditions: Aphasia, Acquired; Aphasia Primary Progressive

Summary: spaced repetition training has been found to be more effective than massed repetition for individuals with aphasia. this study seeks to examine the relative efficiency of three kinds of spacing for picture-naming training: traditional random presentation, non-adaptive spaced repetition, and adaptive spaced repetition.

participants undergo a screening evaluation including the quick aphasia battery (administered via teleconferencing software), and a preliminary picture naming test of approximately 300 pictures, used to select individual items for treatment. participants then undertake online picture naming training for 30 minutes a day, over two weeks. pictures are repeated according to three different schedules to be compared: random presentation, non-adaptive spaced repetition, and adaptive spaced repetition. we compare the number of pictures successfully learned and the verbal reaction time for the pictures assigned to the three conditions.

Eligibility criteria:
inclusion criteria: * presence of a post-stroke word finding deficit (i.e. aphasia), or primary progressive aphasia. * ability to evaluate the correctness of one's own responses when subsequently provided the with the correct answer exclusion criteria: * diagnosis of a neurological disorder other than post-stroke or primary progressive aphasia * inability to evaluate the correctness of ones responses when subsequently provided with the correct answer

Keywords: adaptive spaced-retrieval aphasia anomia anki