Kornimate/medical-research-clean huggingface dataset:
tumor markers in lung cancer: dcamlk-1lk-1

Conditions: Lung Cancer; Smoking

Summary: dcamlk1 is a ca2+ - ca/modulin (cam) - dependent protein kinase that is a marker of stem cells in colonic crypts. mutations within the stem cell population are thought to be responsible for the development of most colorectal carcinomas and studies have shown that dcamlk1 is highly expressed in these tumors. since the lung is an embryological development of the foregut, the investigators speculate that dcamlk1 will also be upregulated in lung cancers. the aim of this pilot study is to measure dcamlk1 levels in the blood of patients with suspected malignant and benign lung diseases, and to correlate dcamkl1 levels with smoking status.

in the investigators' preliminary study dcamkl1 antigen was detected not only in malignant tissue, but also in bal fluid from patients with benign lung disease. this suggests that dcamkl1 expression might be induced by smoking or benign lung diseases. to examine this hypothesis, the investigators will compare dcamlk1 expression in blood from patients with lung cancer to controls who are current or former smokers with benign lung disease. previous work has showed that dcamlk1 is not detectable in the blood of healthy non smoking individuals. to determine whether smoking and or pulmonary inflammation induce dcamlk1 expression, the investigators will obtain serum samples from 20 control patients with lung disease who are seen in the chest clinic at the oklahoma city vamc. smoking histories will be obtained for all participants and dcamlk1 levels will be correlated with smoking status.

Eligibility criteria:
inclusion criteria: * \>45 years of age exclusion criteria: * unable to provide informed consent

Keywords: lung cancer smoking
per-oral endoscopic myotomy

Conditions: Achalasia

Summary: this is a prospective chart review/data collection study of the per oral endoscopic myotomy (poem) procedure, that will include questionnaires administered throughout the study. subjects enrolled will be those intending to have a poem procedure. data will be collected and reviewed through 12 months post-op.


Eligibility criteria:
inclusion: 1. diagnosis of achalasia 2. age 18-75 3. mentally competent to give informed consent 4. scheduled to undergo a poem procedure exclusion: 1. pregnant women 2. any prior surgical treatment for achalasia

Keywords: achalasia myotomy endoscopic myotomy difficulty swallowing
au-ag-cu2o ng with ptt anti drug-resistant microbial keratitis

Conditions: Keratitis, Ulcerative; Antibiotic Resistance, Microbial; Photothermal Therapy

Summary: this clinical study was conducted to evaluate the efficacy and safety of gold-silver cuprous oxide composite nanogels combined with photothermal therapy system in the treatment of severe drug-resistant bacterial keratitis ineffective by traditional antibiotic treatment in human eyes, and to provide translational applications. based on the clinical evidence, a more effective and safe innovative treatment plan for corneal diseases has been developed.


Eligibility criteria:
inclusion criteria: 1. the monocular cases of severe infectious keratitis admitted to our center were diagnosed as fungal keratitis according to their medical history, physical signs and surface secretions smear examination of corneal ulcer lesions (severe was defined as subjects with visual acuity \ 2mm, with extensive infiltration around or with extensive suppuration) 2. after more than 2 weeks of active treatment with antibiotics, there was no effect 3. the researchers communicated with the subjects in detail, and the subjects cooperated well and they voluntarily participated and signed informed consent exclusion criteria: 1. allergic to the drug in this test. 2. pregnant and lactating women. 3. the medical history suggests serious heart, lung, liver, kidney dysfunction. 4. patients with other factors that would affect the results of this result. 5. no signed informed consent.

Keywords: photothermal therapy keratitis, ulcerative antibiotic resistance, microbial
ibuprofen with or without acetaminophen for low back pain

Conditions: Low Back Pain

Summary: this is a randomized clinical trial comparing two interventions for acute low back pain: 1. ibuprofen + acetaminophen 2. ibuprofen + placebo participants will include patients who present to an emergency room for management of low back pain. medication will be dispensed to participants at the time of emergency room discharge. data will be collected from participants by telephone for 1 week.


Eligibility criteria:
inclusion criteria: present to emergency room primary for management of lbp, defined as pain originating between the lower border of the scapulae and the upper gluteal folds. flank pain, that is pain originating from tissues lateral to the paraspinal muscles, will not be included. * musculoskeletal etiology of low back. patients with non-musculoskeletal etiologies such as urinary tract infection, ovarian cysts, or influenza like illness will be excluded. the primary clinical diagnosis, at the conclusion of the emergency room visit, must be a diagnosis consistent with non-traumatic, non-radicular, musculoskeletal low back pain. * patient is to be discharged home. * age 18-69 * non-radicular pain. patients will be excluded if the pain radiates below the gluteal folds in a radicular pattern. * pain duration \<2 weeks (336 hours). * prior to the acute attack of lbp, back pain cannot occur more frequently than once per month. * non-traumatic lbp: no substantial and direct trauma to the back within the previous month * functionally impairing back pain: a baseline score of \> 5 on the roland-morris disability questionnaire exclusion criteria: * not available for follow-up * pregnant * chronic pain syndrome defined as use of any analgesic medication on a daily or near-daily basis * allergic to or intolerant of investigational medications
feasibility of a vocational rehabilitation intervention for job retention in workers with ms-rialsm intervention project

Conditions: Multiple Sclerosis; Vocational Rehabilitation

Summary: multiple sclerosis (ms) is an autoimmune demyelinating disease of the central nervous system with both inflammatory and degenerative characteristics that affects approximately 136,000 people in italy. the highest incidence of disease onset occurs between the ages of 20 and 40, which corresponds to the most productive period of a person's life. for this reason, one of the main social consequences of ms is the reduction or abandonment of work activity, which often begins in the early stages of the disease. vocational rehabilitation (vr) interventions, as reported in the literature, are used to manage and reduce work-related difficulties. the goal of vr is to enable individuals who experience difficulties in performing work activities to access, find, and maintain employment. this approach is characterized by its multi-professional and multidimensional nature, involving different types of interventions carried out by various professionals in diverse settings. the overall aim of the project is to define a vocational rehabilitation (vr) protocol to reduce work-related challenges and promote job retention for workers with ms within the italian healthcare and social context. the intervention will be organised into three different areas: rehabilitation, reasonable accommodation and education. participants will receive any of the three interventions or a combination of these. the study will involve a multidisciplinary team of doctors (e.g. neurologist, physiatrist), psychologists, occupational therapists, physiotherapists, social workers, and labour law experts who will be involved according to the subject's specific needs.


Eligibility criteria:
inclusion criteria: * confirmed ms diagnosis * age ≥18 years * currently employed at the beginning of the study entry * have worked at least one day in the last 12 months * msq-job \>=15 * written informed consent exclusion criteria: * presence of other pathologies impacting on work productivity

Keywords: multiple sclerosis vocational rehabilitation occupational rehabilitation return to work work maintenance work placement vocational guidance reasonable accomodation
human intestinal microbiome and surgical outcomes in patients undergoing colorectal cancer surgery

Conditions: Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum

Summary: intro: recent studies on colorectal cancer surgery have been focusing on the role of intestinal microbiome on surgical outcomes. standard perioperative cares, like mechanic bowel preparation (mbp), administration of antibiotics (abt) and surgery-related stress and injury influence the microbiome composition and possibly induce a shift toward a microbiome dysbiotic state, which predisposes to complicated postoperative course. microbiome composition changes and enhanced virulence factors may increase the risk of postoperative complications, such as anastomotic leakage (al), surgical site infection (ssi), and postoperative ileus (pi), which are known to impact on patient's overall survival and cancer recurrence. objective: the primary objective is to investigate if a significant association might exist between the microbiome composition and the occurrence of postoperative complications at 90 days. methods: 3 different microbiome samples will be taken from all patients. two fresh fecal samples for detection of lm and fecal water preparation: a) a day before the surgery before mbp and/or abt (lm1), b) postoperatively after first bowel movement (lm2). one sample will be taken intra-operatively from the stapled resection lines of circular stapler used for forming a colorectal anastomosis, to detect the mam and to perform immunohistochemistry staining for detection of hace1 expression. dna analysis will be performed for all samples. ihc will be performed for detecting hace1 expression in the tumor and colorectal anastomosis tissues using anti-hace1 antibodies. . for proliferation assessment, human colon carcinoma cell lines ht29 will be plated in monolayers and scratched with a single scratch. monolayers will be incubated for 24 hours with fecal water from patients with surgical complications and matched control patients without complications. descriptive statistics will be performed to describe the study population. this project aim to describe microbiome composition and its impact on postoperative complications.


Eligibility criteria:
inclusion criteria: * adult ≥ 18 years old * with histologically confirmed rectal or left colon adenocarcinoma by biopsy material from colonoscopy * having elective colorectal surgery after standardized bowel preparation * affiliated to a social security system * signature of informed consent exclusion criteria: * major surgery 30 days before scheduled colorectal surgery * administration of systemic antibiotic therapy within 30 days prior to planned colorectal surgery * presenting a contraindication to elective colorectal surgery * patient protected by law * pregnant or breastfeeding woman

Keywords: intestinal microbiome colorectal cancer mechanical bowel preparation postoperative complications anastomotic leakage
teaching method with simulation in gestational diabetes mellitus management

Conditions: Diabetes, Gestational

Summary: gestational diabetes mellitus is one of the common risk factors of pregnancy and occurs for the first time during pregnancy. it adversely affects maternal and fetal health and causes an increase in morbidity and mortality rates. in this context, it is very important to identify possible risks for gdm, plan, implement and evaluate initiatives, provide emergency crisis management in a short time without damage, and increase the self-confidence of midwives. in recent years, interest in simulation methods and skill acquisition training in midwifery education has increased. research; in the management of gdm, to increase the satisfaction and self-confidence level of midwifery students in learning, to evaluate the simulation design and educational effectiveness, it was planned to use the scenario-based near-realistic simulation method in the form of randomized control-intervention quantitatively, and in qualitative design to evaluate the students' views on the method and educational effectiveness. the research will make it easier for midwifery students to intervene with the patient in a shorter time, with confidence and with sufficient clinical skills, and patient safety will be increased. in addition, it will allow the reduction of erroneous clinical practices and malpractices. this study aims to evaluate the satisfaction and self-confidence status of midwifery students and the educational effectiveness of the scenario-based simulation method with high closeness to reality in gdm management and to examine the opinions about this method to fill the gap in the literature.


Eligibility criteria:
inclusion criteria: * agreeing to participate in the research, * being a midwifery 3rd year student and taking the "risky pregnancy" course, * those who have no previous clinical experience in gdm (health college, health vocational high school graduate, etc.) exclusion criteria: * to fill in the data collection forms of the study incompletely, * not participating in all applications of simulation training with high proximity to reality, * desire to leave the research.
modulation of sagittal spinal geometry in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: the aim of this study will be to evaluate the the effect of thera togs soft orthotic undergarment on modulation of the spinal geometry and mobility in sagittal plan in children with spastic diplegic cerebral palsy.

forty children with spastic diplegic cp will be assigned and randomly distributed into two equall groups (a\& b). control group (a) will receive conventional rehabilitation program for postural correction 2 hours/3 sessions' weekly/3 successive months. study group (b) will receive conventional rehabilitation protocol as in group (a) plus wearing theratogs soft orthotic undergarment. children evaluation will be carried out before and after the intervention programs to assess postural deviations using the formetric system.

Eligibility criteria:
inclusion criteria: * have a definite diagnosis of spastic diplegia obtained from medical files or personal physicians and supported by magnetic resonance images (mris). * their weight should be less than 40 kg. * the degree of spasticity in the affected lower extremity will ranged between grades (1, 1+\&2) according to modified ashworth scale. * the levels of gross motor function will be selected at level ii according to gross motor function classification system. * the children will be included have the ability to stand alone for five minutes. * children should be able to understand and follow instructions. * the degree of the spinal kyphosis ,for all participated children , in sagittal plane should be not more than 55° as kyphosis above 55° is considered as fixed hyper-kyphosis while exclusion criteria: * children with gmfcs levels iii, iv, and v or use any assistive mobility devices * children suffering from allergic problems in their skin. * children with visual, auditory or cognitive deficits. * fixed and significant deformities of the lower limb and spine. * children with surgical interference for the lower limb and spine within the previous 2 years. * children with seizures. * children with fixed hyper-kyphosis (kyphotic angle is more than 55°). * children who used any medications (e.g., steroids) that affect growth or body composition.
comparative clinical and radiographical evaluation of treatment of angular bone defect related to over erupted tooth using gtr followed by orthodontic intrusion versus orthodontic intrusion followed by gtr

Conditions: Bone Loss; Occlusion

Summary: occlusal prematurity leading to loss of vertical stopping points between teeth can lead to teeth over eruption creating abnormal contact area which favors food accumulation and plaque retention. all these factors can lead to gingival inflammation and bone loss which may be worsen by abnormal occlusal force. thus, orthodontic evaluation and treatment with periodontic therapy is mandatory to achieve proper treatment. aim of the work: to evaluate and compare clinically and radiographically between effect of guided tissue regeneration (gtr) followed by orthodontic intrusion versus orthodontic intrusion followed by gtr in treatment of over erupted tooth with angular bone loss

abstract occlusal prematurity leading to loss of vertical stopping points between teeth can lead to teeth over eruption creating abnormal contact area which favors food accumulation and plaque retention. all these factors can lead to gingival inflammation and bone loss which may be worsen by abnormal occlusal force. thus, orthodontic evaluation and treatment with periodontic therapy is mandatory to achieve proper treatment. aim of the work: to evaluate and compare clinically and radiographically between effect of guided tissue regeneration (gtr) followed by orthodontic intrusion versus orthodontic intrusion followed by gtr in treatment of over erupted tooth with angular bone loss material and methods: twenty teeth in ten cases were selected with at least two teeth with vertical over eruption and angular bone loss with presence of their opposing for spilt mouth study aged from 20- 35 years old. in group 1 (g1), ten teeth over erupted with angular bone loss were treated by gtr followed by orthodontic intrusion whereas, in group two (g2) ten teeth over erupted with angular bone loss were treated by orthodontic intrusion followed by gtr. all cases were evaluated clinically for pocket depth (pd), bleeding on probing (bop), tooth mobility prior starting phase one therapy, at re-evaluation and at six- and 12-months post starting either gtr or orthodontic intrusion. also, radiographical evaluation was assessed using cbct scan at end of re-evaluation, at six- and 12-months post starting either gtr or orthodontic intrusion to evaluate amount of orthodontic intrusion, amount of change of bone area and length related to angular defect in both groups.

Eligibility criteria:
inclusion criteria: * over erupted tooth with angular bone loss with presence of opposing * mobility doesn't exceed grade two * no gingival recession more than 3mm exclusion criteria: * systematic diseases that complicate oral surgery such as hyperparathyroidism, bleeding disorders,....etc. * smokers * patients with negative attitude towards oral hygiene

Keywords: overerupted tooth angular bone loss orthodontic intrusion
chemotherapy for patients with non-small cell lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: the purpose of this study is to assess the efficacy and toxicity of pemetrexed dosing that is tailored to individual patient tolerance in patients with advanced non-small cell lung cancer (nsclc).


Eligibility criteria:
inclusion criteria: * histologic or cytologic diagnosis non-small cell lung cancer (nsclc) (stage iiib or iv) * patients' nsclc must have progressed following one chemotherapy regimen for palliative therapy with or without subsequent targeted biological therapy * disease status must be that of measureable disease as defined by response evaluation criteria in solid tumors (recist) criteria * eastern cooperative oncology group (ecog) performance status 0 to 1 exclusion criteria: * concurrent administration of any other tumor therapy * pregnancy or breast feeding * serious concomitant disorders * inability or unwillingness to take folic acid or vitamin b12 supplementation
evaluation of the 24/7 eeg subq system for ultra long-term recording of patients with epilepsy involving the temporal lobe region.

Conditions: Epilepsy

Summary: the 24/7 eeg™ subq system will be compared to simultaneously recorded video-eeg in the epilepsy monitoring unit (gold standard) and to self-reported seizure log books throughout 12 weeks of outpatient eeg recording. the present study is a 12-week open-label, prospective study with a paired, comparative design for pivotal evaluation of the safety and effectiveness of the 24/7 eegtm subq system in subjects with epilepsy involving the temporal lobe region . 2-5 sites in europe up to 10 sites in us


Eligibility criteria:
inclusion criteria 1. subject is 18-75 years old. 2. semiology of seizures compatible with temporal lobe involvement. 3. paraclinical findings supporting temporal seizure involvement. such proof may consist of: - previous eeg recording interpreted as compatible with temporal involvement or - radiological findings demonstrating pathology in the temporal area (ct, mri, fdg-pet or spect). 4. uncontrolled epileptic seizures. 5. subject has planned clinical emu admission with an admission goal including capturing epileptic seizures, within 12 weeks after the date of uneeg™ subq implant. 6. subject is willing and able to provide written informed consent. 7. subject is able to complete all study-required procedures, assessments and follow-up. exclusion criteria 1. subject has a condition that places him/her at a high at high risk of surgical complications, such as an active systemic infection or a hemorrhagic disease. 2. subject receives frequent (more than 2 days per week) treatment with drugs of the following types: 1. antiplatelets 2. anticoagulants 3. chemotherapeutics 4. non-steroid anti-inflammatory drugs (nsaid) 3. subject has skeletal deformities or damage at the proposed implantation site to an extent that impedes correct electrode placement. 4. subject is involved in therapies with other active implantable devices that deliver electrical energy above the clavicular area, such as implantable brain stimulation, external/transcranial brain stimulation, vagus nerve stimulator (vns) and cochlear implant(s). 5. subject is pregnant 6. subject has contraindicated profession or hobby 7. subject is scheduled to undergo contraindicated treatments/investigations 8. infection at the implant site 9. subject has contraindication to the use of anesthetic used for in/ex plantation. 10. subject is unable to use/operate the device system 11. subject has abnormal laboratory findings as follows: * serum creatinine ≥ 3 times upper reference value * alanine aminotransferase (alt), alkaline phosphatase or bilirubin ≥ 3 times upper reference value * activated partial thromboplastin time (aptt) \&gt; 50 seconds * thrombocyte count \&lt; 50 or \&gt;1000 x 109/l * international normalised ratio (inr) ≥ 1.6 * any other clinical or paraclinical finding that in the opinion of the investigator would interfere with participation in the study or would confound interpretation of the study results.

Keywords: ultra long-term recording of patients with epilepsy