Kornimate/medical-research-clean huggingface dataset:
development of novel adhesive sports tape modular to facilitate use of discomfort

Conditions: Cardiovascular Disease

Summary: special metals (e.g. germanium, titanium, and π element) can be used to produce far-infrared radiation. the applications of these metals in promoting blood circulation are worth investigating. this clinical trial recruited subjects for using tape made up of ge, ti, and π element developed by green energy nano technology co., ltd. we assumed that the experimental tape can improve the participants' peripheral blood circulation and their quality of life. in this clinical trial, the clinical efficacy and safety of the test products were assessed using physical examination and questionnaires.

this study is made of two open-labeled, two-arm studies. 20 to 80 years old patient diagnosed with varicose veins were included in the study. besides, patient with the following characteristics was excluded: vulnerable group, patient with an open wound at lower limb which cannot be taped, unable to express willingness clearly, dyslexia, and inability to ambulate. the final number of total participant is 86 participants and 66 out of 86 participants were assigned to the first study which is divided into 2 groups, the experimental and control group. the experimental group received the experimental tape as treatment, and the control group didn't receive any treatment. the participants will fill in the questionnaires including visual analogue scale and quality of life on the first day of the study, and fill the same questionnaires seven days later. furthermore, the rest of the 20 participants were assigned to the second study. the researchers evaluate their peripheral blood circulation by segmental blood pressure over pulse volume recording (sbp/pvr), maximum venous outflow over segmental venous capacitance (mvo/svc), and ankle brachial index (abi) before they received the treatment, then the researchers inspect the same indexes after they received the treatment right after the first tests.

Eligibility criteria:
inclusion criteria: * cardiovascular disease (deep vein thrombosis or chronic venous insufficiency) exclusion criteria: * vulnerable populations * wound at lower limb which can not take the intervention * one can not make express consent clearly * dyslexia * who need physical assistance during ambulation * nonfunctional ambulator
serotonin levels in atopic dermatitis patients

Conditions: Dermatologic Disease

Summary: atopic dermatitis (ad) is a chronic pruritic inflammatory skin disease of unknown aetiology. global prevalence rates range from 1%-20%.ad is often worsened by stress and anxiety.plasma levels of 5-ht were found to be positively correlated with the disease severity.

atopic dermatitis (ad) is a chronic pruritic inflammatory skin disease of unknown aetiology. the condition typically starts in infancy with changing presentations over the years. incessant pruritus is the main symptom. main findings include: xerosis, eczematous lesions, ig e reactivity, relapsing course and personal or family history of other atopic diatheses .global prevalence rates range from 1%-20%. ad is often worsened by stress and anxiety. moreover, a mutual relationship between the neuroendocrine system and the immune system; including the skin has been suggested. different mediators are responsible for this relation. serotonin is considered as one of the most important responsible mediators (5-hydroxy-tryptamine; 5-ht) . patients with ad have been reported to have high serum levels of 5-ht. moreover, plasma levels of 5-ht were found to be positively correlated with the disease severity. however and to the best of the investigators' knowledge, no studies have addressed this point in egypt. treatment of ad includes: elimination of triggers, emollients, topical therapies, and systemic modalities including ssris (selective serotonin reuptake inhibitors) and tcas (tricyclic antidepressants) in certain cases. ssris block the reuptake of serotonin, thus increase the concentration of serotonin within synaptic clefts. the mechanism of action in relation to pruritus is not understood, but ssris have been used to treat atopic dermatitis associated pruritus

Eligibility criteria:
inclusion criteria: * all patients with the clinical diagnosis of ad. * age more than 2 exclusion criteria: * age less than 2 years. * any concomitant systemic or dermatological disease. * patients on any topical or systemic treatment during the past one month. * uncooperative patients. * refusal to participate

Keywords: atopic dermatitis serotonin
brain-based understanding of individual language differences after stroke

Conditions: Aphasia; Stroke; Alexia

Summary: strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. the build study aims to understand the brain basis of these individual differences in stroke outcome. participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. each participant will have between three and six sessions, including an mri to measure details of the structure, function, and connections in the brain. the data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. ultimately, we hope that build will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.


Eligibility criteria:
inclusion criteria: stroke survivors: * age \>=18 * stroke in left hemisphere of brain with or without aphasia, or stroke elsewhere causing aphasia * learned english at 8 years or younger controls: * age \>=18 * no history of brain injury resulting from stroke, trauma, infection (i.e. encephalitis), or tumor * learned english at 8 years or younger exclusion criteria: * history of other brain conditions that could impact interpretation of results (such as multiple sclerosis, premorbid dementia) * severe psychiatric condition that would interfere with participation in the study * history of a learning disability that could impact interpretation of results additional exclusion criteria for mris: * pacemaker or magnetic metal in the body that is not mri compatible * pregnancy * claustrophobia

Keywords: aphasia stroke brain injury speech language reading alexia apraxia
real world effectiveness, persistence, tolerability, and safety of ofatumumab in clinical practice

Conditions: Multiple Sclerosis

Summary: this was a retrospective cohort study using the electronic medical record (emr) database from cleveland clinic. the data was analyzed at start of ofatumumab (omb) therapy (baseline, defined as 6 months prior to omb initiation) and at 6 or 12 months following initiation of omb.


Eligibility criteria:
inclusion criteria: * patients who initiated omb commercially from the time of disease modifying therapy (dmt) approval (august 2020), and * aged 18 years or older at index date, and * patients who met 2017 mcdonald criteria for clinically definite multiple sclerosis (ms), or * patients diagnosed with clinically isolated syndrome (cis) by cleveland clinic ms specialist. exclusion criteria: those who were participating in omb clinical trials (e.g., artios, olikos)

Keywords: clinically isolated syndrome relapsing-remitting multiple sclerosis secondary progressive multiple sclerosis primary progressive multiple sclerosis
a study of the effectiveness and safety of nivolumab plus chemotherapy in participants with untreated advanced/recurrent gastric cancer

Conditions: Stomach Neoplasms

Summary: the purpose of this study is to assess the effectiveness, safety, and actual treatment status of first-line nivolumab plus chemotherapy in participants with untreated advanced / recurrent gastric cancer in a japanese real-world setting.

the time perspective for this observational study is defined as 'retrospective and prospective'.

Eligibility criteria:
inclusion criteria: * histologically confirmed advanced or recurrent gastric cancer * have initiated or are confirmed to receive nivolumab plus chemotherapy as the first-line therapy between the date of approval of nivolumab plus chemotherapy and december 31, 2022. for combination chemotherapy, sox, capeox, or folfox is acceptable * have signed a written informed consent form of their own free will after they have been given an adequate explanation and a full understanding of this study before enrolling in this study. exclusion criteria: * treated with antineoplastic agents as first-line treatment for advanced or recurrent gastric cancer prior to the initiation of nivolumab plus chemotherapy (participants who have received prior perioperative chemotherapy and participants who have received prior bisphosphonates for osseous metastases may be enrolled) * confirmed to be positive for her2 * diagnosed with gastric cancer and have previously received investigational drugs with anti-tumor effects * initiated with nivolumab plus chemotherapy as the first-line treatment for advanced or recurrent gastric cancer at a site other than the study site and were later hospitalized at the study site. * judged by the investigators to be inappropriate for enrollment in this study

Keywords: nivolumab advanced or recurrent gastric cancer
calcium electroporation in patients with cell changes in the esophagus

Conditions: Barretts Esophagus With High Grade Dysplasia

Summary: the aim of this first-in-man study is to evaluate the safety of calcium electroporation used in patients with barrett's esophagus high-grade dysplasia through an endoscopic system.

after being informed about the study and potential risks, all patients give written informed consent. thereafter, patient will get calcium electroporation with biopsies and digital photographs on day 0. we expect to discharge all patients same evening. between day 3-7 an examination is followed by gastroscopy with biopsies and digital photographs. on day 14 the patients are followed in our outpatient clinic. 6 weeks after treatment the patients will undergo endoscopic mucosa resection (emr) or endoscopic submucosa dissection (esd) surgery and thereby the standard care of treatment for barrett's esophagus high-grade dysplasia.

Eligibility criteria:
inclusion criteria: 1. male or female ≥18 years old. 2. histological verified barrett's esophagus high-grade dysplasia (be hgd) 3. expected survival \> 3 months. 4. performance status eastern cooperative oncology group (ecog)/world health organization (who) ≤ 2. 5. platelets ≥ 50 billion/l, international normalized ratio (inr) \< 1.5. medical correction is allowed, e.g. correction of a high international normalized ratio (inr) using vitamin k. 6. subjects must be willing and able to comply with the procedure, such as agreed follow-up visits. 7. sexually active men and fertile women must use adequate contraception during this trial 8. subjects must give written informed consent. exclusion criteria: 1. coagulation disorder that cannot be corrected. 2. subjects with a clinically significant cardiac arrhythmia. 3. concurrent treatment with an investigational medicinal product 4. patients with any other clinical condition or prior therapy that, in the opinion of the investigator, would make the patient unsuitable for the study or unable to comply with the study requirements. 5. pregnancy or lactation a medical doctor will always be responsible for final inclusion of the subject.
psychiatric disorders in addiction - interest of screening and influence on relapse

Conditions: Psychiatric Disorders

Summary: in complex detoxification hospital units, patients receive a common care system (interviews, therapeutic workshops, support for discharges, etc.). in the event of a relapse during hospitalization, i.e., a relapse into addiction, hospital care is called into question, and discharge is generally considered. a key care issue is therefore to prevent these relapses by identifying risk profiles to strengthen their management. according to studies, psychiatric diagnoses increase the risk of relapse, but we do not fully understand which ones or to what extent. the objective of this study is to analyze the influence of psychiatric diagnoses on the risk of relapse. this would allow for adapting the care of these patients to reduce this risk. the investigators are also seeking to study the value of screening questionnaires in improving the reliability of psychiatric diagnoses.


Eligibility criteria:
inclusion criteria: * subject aged ≥16 * having been hospitalized in the complex withdrawal unit of the strasbourg psychiatric clinic during the period from january 1, 2024 to november 1, 2024 exclusion criteria: * refusal to participate in the study

Keywords: psychiatric disorders addiction complex detox
bfr in overweight sedentary subjects

Conditions: Overweight

Summary: this project should allow the investigators to observe the effects of low load training under partial vascular occlusion (bfr) in comparison with resistance training at low load without partial vascular occlusion in sedentary people overweight on parameters : decrease in fat mass; increase in muscle mass 79; muscle strength; decrease in the energy cost of walking; increase in preferred walking speed; improvement in walking pattern in patients overweight. training under partial vascular occlusion should facilitate physical activity in overweight people as it can be just as effective as a "classic" type training with heavy loads. thus, this device could allow people for who wear heavy loads can present an obstacle to physical activity to feel more involved in the physical activity programs offered in medical or sports centers.

the main objective of this study is to observe the effects of low load training under vascular occlusion (bfr) compared with low load resistance training without vascular occlusion in overweight sedentary people on parameters such as: decrease in fat mass; lower blood sugar levels as well as lower blood triglycerides and cholesterol levels; increased muscle mass; muscle strength; the reduction of the energy cost of walking; increasing the preferred walking speed; improving the walking pattern in overweight patients. 3.2 primary and secondary endpoints the first hypothesis is that the bfr drive will be effective in improving walking economy (thus reducing the energy cost of walking) and increasing the preferred walking speed, by improving walking patterns. the second hypothesis is that bfr training makes it possible to modify the body composition in a slight way and to promote the gain of muscle strength in overweight individuals who do not practice physical activity beforehand. in addition, blood tests will show a decrease in blood sugar, blood triglyceride levels and cholesterol. 3.3 study design this single-center project aims to test the effects of low-load training under partial vascular occlusion (bfr) compared to low-load resistance training without vascular occlusion in overweight sedentary people. the main expected effects are a decrease in fat mass, an increase in muscle mass and strength, a decrease in the energy cost of walking as well as an increase in preferential walking speed. this project is part of a continuity of research in a public health context in order to propose adapted and effective physical activity programs for an overweight population unable to train with heavy loads.

Eligibility criteria:
inclusion criteria: * imc between 25 and 35 * vaccin against covid-19 exclusion criteria: hypertension diabete

Keywords: blood flow restriction
comparison of the analgesic effects of dronabinol and smoked marijuana in daily marijuana smokers

Conditions: Pain Threshold; Mood

Summary: the following study is designed to determine the analgesic efficacy of smoked marijuana (0, 1.98, and 3.56% thc) and oral thc (0, 10, and 20 mg) in the cold-pressor test (cpt), a laboratory model of pain which has predictive validity for clinical use of analgesics. oral thc (dronabinol) is known to have a slower onset and longer duration of action compared with smoked marijuana. therefore, the analgesic effects of oral thc is expected to peak later and last longer than effects produced by smoked marijuana.

laboratory animal studies have demonstrated the analgesic effects of drugs which act on the cannabinoid system, however, these effects have et to be clearly elucidated in humans. to better understand the potential clinical application of cannabinoids for pain management, the following study is designed to determine the analgesic efficacy of smoked marijuana (3.56% thc) and oral thc (20 mg) in the cold-pressor test (cpt), a laboratory model of pain which has predictive validity for clinical use of analgesics. non-treatment seeking marijuana smokers will be recruited for a five-session study during which the analgesic, subjective, and physiologic effects of cannabinoids will be evaluated. determining the efficacy of cannabinoids in an experimental model of pain will provide important endpoints (i.e., dose, route of administration, time course) or this effect to further investigate the potential role for clinical use of smoked marijuana and/or oral thc as analgesics.

Eligibility criteria:
inclusion criteria: * adults between the ages of 21-45 * current marijuana use * able to perform study procedures * women practicing an effective form of birth control exclusion criteria: * female subjects who are currently pregnant or breastfeeding * current,repeated illicit drug use other than marijuana * presence of significant medical illness * history of heart disease * request for drug treatment * current parole or probation * recent history of significant violent behavior

Keywords: oral thc cannabis pain analgesic effects dronabinol
urogynecological and sexual functions after vecchietti operation

Conditions: Mayer-Rokitansky-Kuster Syndrome

Summary: the aim of this study was to establish the urogynecological and sexual functions after vecchietti operation.

thirteen patients with mrkhs who underwent laparoscopic vecchietti vaginoplasty were included. a control group of 13 age-matched, childless, sexually active women were examined during the same period. all patients underwent the basic evaluation of anatomical outcomes. sexual outcomes were established by polish validated fsfi questionnaire. continence status was assessed by polish validated udi-6 and iiq-7 questionnaires. the udi-6 is subdivided in three domains: stress incontinence, irritative and obstructive discomfort. the iiq-7 measures the implications of urinary incontinence for normal daily functioning.

Eligibility criteria:
inclusion criteria: * patients with mrkhs who underwent laparoscopic vecchietti vaginoplasty * control group of 13 age-matched, childless, sexually active women exclusion criteria: * unability to understand informed consent

Keywords: laparoscopic vecchietti vaginoplasty sexual function urinary incontinence
lateral canthal rhytides with medium depth chemical peel with or without pretreatment with botulinum toxin a

Conditions: Wrinkles

Summary: this study is being done to find out if the use of botulinum toxin prior to a medium strength combination chemical peel (jessner's peel followed by 35% trichloroacetic acid peel) will improve the appearance of crow's feet wrinkles when compared to a chemical peel alone. botulinum toxin type a is a purified substance, derived from a bacteria that block muscular nerve signals. jessner's peel, a combination of resorcinol (14g), salicylic acid (14g), and lactic acid (85%) in ethanol (95%), is a superficial chemical peel. these two products/procedures have been fda approved to improve the appearance of facial wrinkles.

wrinkling in the skin is caused by habitual facial expressions, aging, sun damage, smoking, poor hydration, and various other factors. there are two major types of wrinkles-dynamic and static. dynamic wrinkles, which are due to excessive muscle activity, usually of the face, tend to disappear when you relax your facial muscles. the most common of these dynamic wrinkles are frown lines, forehead wrinkles, and eye wrinkles (or crow's feet). however, if the excessive muscle activity is carried on for too long, these do not disappear completely on relaxation, and are thus called static wrinkles. static wrinkles are formed either by chronic excessive muscle activity or are due to the effects of age and gravity, with a loss of subcutaneous fat. examples of static wrinkles are the nasolabial folds, which are the deep grooves running from the sides of the nose to the corners of the mouth.

Eligibility criteria:
inclusion criteria: * age 30 to 75 years old * in good health * has static and dynamic lateral canthal wrinkles ("crow's feet") * has the willingness and the ability to understand and provide informed consent and communicate with the investigator exclusion criteria: * pregnant or lactating * has received the following treatments: * botulinum toxin injections in the past 6 months * ablative laser procedure in the past 6 months * radiofrequency device treatment in the past 6 months * ultrasound device treatment in the past 6 months * medium to deep chemical peel in the past 6 months * temporary soft tissue augmentation material in the past year * semi-permanent soft tissue augmentation material in the past 2 years * permanent soft tissue augmentation material * is planning to receive within the next 3 months, any cosmetic procedure (such as any chemical peels, botulinum toxin injections, ablative or non-ablative laser procedures, filler injections, radiofrequency procedures, dermabrasion, ultrasound and face lifting procedures) * has an active infection on their face (excluding mild acne * has a history of neuromuscular disorders * has an allergy to albumin * has an allergy to aquaphor and petroleum jelly * has a history of bleeding disorders * is unable to understand the protocol or to give informed consent * has a mental illness
nalmefene gambling study: study of nalmefene hcl in the treatment of pathological gambling

Conditions: Pathological Gambling

Summary: the purpose of this study is to determine if nalmefene is safe and effective in the treatment of pathological gambling.

randomized, double-blind, placebo-controlled, parallel-group, multi-centered, outpatient study to assess the efficacy, safety and tolerability of two doses of nalmefene in patients with current diagnosis of pathological gambling.

Eligibility criteria:
inclusion criteria: * current diagnosis of pathological gambling as defined by diagnostic and statistical manual of mental disorders, fourth edition, text revision (dsm-iv-tr)