Kornimate/medical-research-clean huggingface dataset:
effect of suturing protocols on coronally advanced flap for root coverage outcomes

Conditions: Gingival Recession

Summary: the purpose of this retrospective study is to investigate whether suturing protocols (suture removal timing) influence root coverage outcomes in recession defects treated with a coronally advanced flap (caf) procedure.

the aim of this study is to assess whether the timing of suture removal may influence the number of sites exhibiting complete coverage (crc) or the mean root coverage (mrc) obtained in single-tooth recession-type defects treated by coronally advanced flap (caf). records from patients that underwent a coronally advanced flap (caf) procedure for root coverage will be analyzed. this surgical procedure is aimed at the treatment of root recessions that may arise following periodontal disease or mechanical trauma. the procedure, after obtaining deep local anesthesia, involves a sulcular incision on the buccal side and extending the incision mesially and distally to the base of the adjacent papillae. two vertical incisions are then made at the corner of the adjacent tooth line and extended into the alveolar mucosa. a mixed thickness flap is then elevated and coronally advanced by releasing incisions through the periosteum to allow for flap placement to cover the recession without tension. the papillae are de-epithelized to provide the bed of connective tissue for the adaptation of the flap which is then sutured with single stitches. the records, complete with photographic documentation, of all patients who have undergone this procedure will be identified and will be divided into two groups: those in which the sutures were removed at 2 weeks and those in which the sutures were removed at 3 or more weeks. crc as present or absent (yes/no) and mrc (percentage of roof surface that has been successfully covered) six months after surgery will be assessed in these patients. the presence of patient discomfort on the day of suture removal will be recorded as present / absent to assess whether the permanence of the sutures for longer or shorter influences the patient's perception of the surgery. the results will be compared between the two groups.

Eligibility criteria:
inclusion criteria: * patients not affected by active periodontitis * single recessions on non-restored non-molar teeth * caf protocols using vertical releasing incisions * records of patients clearly reporting timing of suture removals and root coverage outcomes at 6 months exclusion criteria: * adjacent recessions * recessions on molar teeth * coronally advanced flaps without releasing incisions * patients with active periodontitis

Keywords: gingival recession sutures root coverage healing
transdermal nitroglycerin and nifedipine in preterm labor

Conditions: Managing Preterm Labor

Summary: one of the important complications of pregnancy is preterm labor (ptl) and delivery. there are different tocolytic agents to enhance the time of delivery. the aim of this study was to compare the effect of transdermal nitroglycerin (glyceryl trinitrate, gtn) and oral nifedipine for managing preterm labor. this was a randomized clinical trial in women admitted with diagnosis of ptl. group one have received transdermal gtn whereas group two have received oral nifedipine, vital signs, fhr, contractions, dilation and effacement as well as gestation age at the time of delivery have been monitored and evaluated in both groups of patient. our main goal has been delay of delivery to have the most beneficial effect of primary corticosteroid administration for fetus.


Eligibility criteria:
inclusion criteria: * ga between 24 to 34 weeks * early-onset signs of delivery (≥4 uterine contractions during 20 minutes, ≥1 centimeters (cm) of dilation and effacement over 80%). exclusion criteria: * maternal or fetal life-threatening conditions which require emergency termination * multiple pregnancy * premature rupture of membrane * fatal anomaly or intra-uterine fetal death * cervical dilation ≥4 cm * any tocolytic treatment in previous days and positive allergy to gtn
leptin and endothelial function

Conditions: Healthy

Summary: the purpose of this trial was to determine if injections of leptin would improve vascular function in normal-weight, healthy volunteers.

the researchers plan to enroll a total of 15 non-obese (bmi \< 27 kg/m2) otherwise healthy adults into a randomized, double-blinded, cross-over study of the impact of recombinant methionyl human leptin 0.2 mg/kg sc, hereafter called rl, (amgen inc, thousand oaks, calif) versus placebo sc (sorbitol and sodium acetate, ph 4.0 of same volume) in 15 non-obese adults. subjects will have baseline vascular studies performed by brachial artery ultrasonography-flow-mediated dilatation and nitroglycerin mediated dilatation and blood drawn for measures of leptin levels. they will then receive rl sc or placebo sc (randomized order). they will then have vascular studies performed and blood levels drawn every 2 hours for 6 hours total. after completion of day 1, patients will return 1-4 weeks later and repeat the protocol crossed-over to the alternate intervention (rl or placebo).

Eligibility criteria:
inclusion criteria: * healthy male or female ages 18-50. * bmi \< 27 kg/m2 for lean group exclusion criteria: * any cvd risk factor (diabetes or fasting glucose \> 126 mg/dl * hypertension or measured bp \> 140/90 mmhg * current tobacco smoking within last month * ldl\>160 mg/dl, hdl\<35 mg/dl) * renal insufficiency (creatinine \> 1.4 mg/dl) * thyroid abnormalities (abnormal tsh) * established cvd (any atherosclerosis, or history of peripheral arterial disease, previous stroke, myocardial infarction, angina, heart failure, aortic aneurysms) * usage of medications which impact endothelial function within last month (folate, fish oil, vitamin c or e, l-arginine, blood pressure or lipid-lowering medications, diabetes medications)
outcome of preserved mitral valve apparatus during mitral valve replacement

Conditions: Diseases of Mitral Valves; Abnormality of Mitral Valve Annulus (Disorder); Mitral Valve Replacement

Summary: are there differences in outcome of mitral valve replacement with preservation of mitral apparatus among rheumatic and/or ischemic mitral lesions?. mitral valve replacement with preservation of leaflets, and added coronary artery-bypass surgery, when indicated, is it a feasible and reproducible procedure?. the study was designed to compare outcome after prosthetic mitral replacement with preservation of mitral apparatus for rheumatic valve disease with outcome of replacement for ischemic myocardium and mitral valve disease, the outcomes will be guided by clinical assessment. and echo-cardiograph.

objectives: the aim is to compare outcome of modified preservation of mitral valve apparatus during prosthetic mitral replacement for rheumatic versus myocardial ischemia \&mitral valve disease. methods ;this prospective cross-sectional comparative study will include 50 patients with isolated rheumatic mitral valve disease (group a) and 50 patients with mitral disease and myocardial ischemia (group b), surgery is expected to be performed between 2017 and 2020 at one center. all patients will have modified preservation of mitral apparatus during prosthetic mitral replacement. additionally, group b patients will have bypass grafts to left anterior descending and/or posterior descending / right coronary artery. data will be collected and analyzed. the institutional review board (irb), ethics committee (ec)-approval and consent of each patient were obtained. criteria for inclusion of patients and exclusion of others were determined according to the guide lines. statistical analysis:: qualitative variables and their association among both groups were studied by applying chi-square test and fisher exact test. quantitative variables among both groups were compared by applying independent samples t-test. p \< 0.05 values mean statistically-significant results.

Eligibility criteria:
inclusion criteria:: mitral stenosis (ms) * symptoms are severely limiting and cannot be managed with diuresis and heart rate control. mitral regurgitation(mr): \* acute severe mr require surgical correction for hemo-dynamics and relief of symptoms . chronic primary mitral regurgitation: \* rheumatic heart disease: replacement before irreversible changes occur can be curative. mixed mitral stenosis and mitral regurgitation: * if beta blockers and diuretics do not relieve symptoms, replacement should be performed only in patients who have severe limiting symptoms. * myocardial ischemia associating or complicated with miral valve disease. exclusion criteria * patients showing good response to medical therapy, and cases complicated by: * ineffective endocarditis, * previous myocardial re-vascularization * ischemic ventricular septal defect, * left ventricular aneurysm, * ruptured papillary muscles of mitral apparatus.

Keywords: : preservation of mitral apparatus , mitral valve replacement rheumatic valve disease and ischemia
study evaluating the safety and efficacy of pf-03049423 in subjects with ischemic stroke

Conditions: Ischemic Stroke

Summary: the purpose of this study is to evaluate the safety and tolerability of pf-03049423 following multiple dose administration to subjects with ischemic stroke. the study will also evaluate the efficacy of pf-03049423, relative to placebo, in subjects with ischemic stroke following 90 days of therapy. the study will also explore the relationship between pf-03049423 concentration and blood pressure.

the interim analysis for the poc study a9541004 demonstrated futility, and the study was stopped on the 6th of november 2013. there were no signals of serious safety concern.

Eligibility criteria:
inclusion criteria: * diagnosis of ischemic stroke with an onset within 72 hours prior to start of study agent administration, male or female. * supratentorial ischemic stroke involving the cortex documented by neurological exam and confirmed by mri. * stroke involving upper extremity. * subjects who received thrombolytic therapy may be enrolled and the use of antiplatelet is acceptable. exclusion criteria: * any other severe acute or chronic medical or psychiatric condition besides the stroke. * women of child bearing potential. * uncontrolled hypertension.

Keywords: phase 2 ischemic stroke safety and efficacy
palliative re-irradiation for progressive diffuse intrinsic pontine glioma (dipg) in children

Conditions: Pediatric Malignant Brain Tumor -Diffuse Intrinsic Pontine Glioma

Summary: although dipg is not curable, re-irradiation with a modest total dose and short treatment time provides good palliation of symptoms, improves quality of life, delays disease progression and has minimal and manageable toxicity. treatment plan: at progression, full radiological and clinical documentation necessary including a neurological exam by a neurologist will be done. progressive patients will be referred to radiotherapy. radiation guidelines: 30.6 gray (gy) will be applied in 1.8 to 2gy fractions in conformal radiation to tumor bed. radiation will be done in standard accelerators and according to standard guidelines used in treatment for all brain tumor patients.


Eligibility criteria:
inclusion criteria: 1. age:1 year-22 years 2. patient/parent consent 3. diagnosis of dipg based on short classic history, clinical signs (long tract signs, cranial nerve deficits and ataxia) and classic mri features (more than 2/3 of the tumor is located within the pons and tumor encompasses more than 60% of the pons) 4. a patient will be eligible for reirradiation if progression is diagnosed following a period of at least 4 months of stable disease after first irradiation. 5. progression may be either clinical (new neurological deficit or worsening of an old deficit in two separate physical examinations) or radiological (tumor growth of \>25%) exclusion criteria: 1. radiation necrosis post first irradiation 2. unstable vital signs 3. less than x months since previous irradiation
pilates on dynamic balance in flexible flat feet

Conditions: Flexible Flatfoot

Summary: flexible flatfoot is one of the most common types of flatfeet. it has an arch that is present in open kinetic chain and lost in closed kinetic chain balance is defined as the process that maintains the center of gravity within the body's support base. pilates exercises is a whole body conditioning program which was initially used for managing low back pain and improving balance in elderly. now-a-days it is used for posture correction and fitness training.

individuals with flatfeet are more unstable when compared with normal individuals during quiet standing. about 10% to 25% of population exhibits a flat foot to varying degrees. in clinical practice, some subjects become symptomatic with feet pain or lower extremity soreness and limitation in their functional activities such as limitation of long-distance walking or running and high-impact sports.patients with flexible flat feet have poorer static and dynamic balance than healthy individuals. taking into consideration effect of flat feet on body alignment, the implication of flat feet on balance have received little attention to date pilates is an individual body-based exercise, it has an advantage in that exercise load can be controlled according to the body's center of balance.pilates based exercise works on the principles of trunk stability, also known as "core stability". "core is described as a box, with the abdominals (transversus) in front, paraspinals (multifidus) in back, diaphragm in top and pelvic floor at the bottom". pilates is a popular form of exercise training program which includes series of stretching and strengthening exercises with proper trunk control and breathing.

Eligibility criteria:
inclusion criteria: 1. subject's age ranged from 18-21 years old 2. subjects had bilateral pronated feet posture according to the navicular drop test by brody method: normal feet (between five and nine mm of navicular drop), a pronated foot (more than 10 mm of navicular drop) 3. body mass index (mbi) ranged from 18.5 to 25 kg/ m2 exclusion criteria: * 1-repeated lower extremity injuries as fractures or deformities. 2-history of surgery to the lower extremity. 3- any neurological deficit affecting balance. 4-any medication can affect the balance. 5- pregnant and breast feeding females
radiosurgery treatment for spasticity associated with stroke, sci & cerebral palsy

Conditions: Spasticity as Sequela of Stroke; Spastic Cerebral Palsy; Spasticity, Muscle

Summary: a scientific study is being done to test a special treatment for people who have spasticity or tight muscles. this treatment is called "stereotactic radiosurgery dorsal rhizotomy." it uses very accurate beams of radiation to target certain nerves in the back to help loosen up the muscles. in this study, people are put into two groups by chance: one group gets the real treatment, and the other group gets a "fake" treatment that doesn't do anything. this fake treatment is called a "sham." doing this helps make sure the study is fair and the results are true. after the people in the study get their treatment, the researchers will watch and see how they do. they will check if their muscles are less stiff and if they have any side effects. by looking at the results from both groups, the researchers can find out if the special treatment really helps people with spasticity. patients who got the "fake" treatment will be eligible to receive the "real" treatment after 6 months.


Eligibility criteria:
inclusion criteria: * chronic spasticity refractory to medical management or in a patient who cannot receive appropriate medical management mediated by one or more spinal nerve roots * age \> 16 (if under 18, patients parents must sign consent). exclusion criteria: * inability to lie supine for simulation \& treatment * inability to visualize the target nerve on either ct or mri imaging * patients with confirmed pregnancy (all women of child-bearing age with intact uterus \& ovaries will be required to undergo a pregnancy test prior to simulation)
pediatric behavioral informatics to prevent cancer

Conditions: Obesity

Summary: the goal of this study is to do formative research which will lead ultimately to the development of a computer-based system called tailored information for diet and exercise or tide for short. tide will target energy balance behaviors to prevent the onset of obesity in children. the system will be used by physicians and parents/primary care givers in pediatric primary care practices with the aim of improving parent-pediatrician interactions related to counseling and anticipatory guidance on energy balance behaviors. the aim of this study is to develop a one-two page, paper-pencil proxy questionnaire that is used to query the parent of the child in the waiting room and assesses topic areas related to energy balance behaviors (ebb). the questionnaire will be referred to as the energy balance behaviors questionnaire (ebb-q). this will require focus groups, cognitive testing of the questionnaire, and survey administration.


Eligibility criteria:
inclusion criteria: * primary care givers or legal guardians of children 4-10 years of age who has attended the last two well-child visits with their child exclusion criteria: * parent cares for a child who is on a special diet prescribed by pediatrician

Keywords: pediatric obesity prevention health behaviors guidelines
urothelial cancer screening in individuals with lynch syndrome using a urine tumor dna panel (ls-uro study)

Conditions: Urothelial Carcinoma; Lynch Syndrome

Summary: lynch syndrome (ls) is an inherited cancer predisposition syndrome caused by pathogenic germline variants in dna mismatch repair (mmr) genes. new cancer screening and diagnostic tools are urgently needed to identify ls-related cancers early enough for curative treatment. urothelial cancers (comprising bladder and upper tract urothelial tumors) are the third most common cancer after colorectal and endometrial cancers in individuals with ls. up to one in four ls individuals will develop urothelial cancer during their lifetime, with the risk varying based on the defective mmr gene. in this clinical trial, we will employ urine tumor dna (utdna) to identify asymptomatic urothelial cancers in lynch syndrome patients, and to investigate the potential benefits of urine tumor dna based screening in this high-risk population.


Eligibility criteria:
inclusion criteria: * willing and able to provide informed consent * diagnosis of lynch syndrome * age 50 - 75 years at study recruitment exclusion criteria: * concurrent urothelial carcinoma

Keywords: lynch syndrome hereditary cancer syndrome screening urothelial neoplasms bladder neoplasms upper tract urothelial neoplasms urogenital diseases liquid biopsies urine tumor dna
evaluation of breast ct

Conditions: Breast Cancer

Summary: the investigators have studied the potential of breast computed tomography (bct) for breast imaging under an nih-funded biomedical research partnership (brp) grant (r01 eb002138-10), and 4 breast ct scanners have been developed that have imaged over 600 women to date (under more than one irb-approved protocol). the brp grant cannot be renewed, and with this (resubmitted) r01 grant application, the investigators seek to finalize the investigators' research in breast ct - the specific aims have been significantly modified as a result of the first critique, and the investigators now focus on a narrower set of remaining issues. this version of the protocol will add breast magnetic resonance imaging (mri) to the experimental procedures.

clinical evaluation: four hundred women who will be having breast biopsy as part of their standard care (birads 4 and 5) will be recruited to undergo additional imaging prior to biopsy, including (research) pre-and post-contrast enhanced breast ct imaging of both breasts, as well as (standard, fda approved) contrast enhanced breast mri. the potential of non-contrast enhanced breast ct will be compared using receiver operating characteristic (roc) methodology against mammography alone, as well as with mammography + tomosynthesis. the breast ct images (including both pre-and post-contrast images) will be compared using roc methodology against standard-of-care contrast-enhanced mri (which includes both non-contrast and contrast images). the results of the clinical trials proposed in this investigation should provide strong evidence in regards to the potential of breast ct for breast cancer screening in the normal risk and high risk populations.

Eligibility criteria:
inclusion criteria: * age at least 35 years old * diagnostic findings from prior mammography highly suggestive of breast malignancy (bi- rads® category 4 or bi-rads® category 5) * not pregnant or breast-feeding * ability to lie motionless for up to 5 minutes exclusion criteria: * recent breast biopsy * history of moderate or severe reaction to contrast agent injection * history of allergy to iodine * history of multiple food and/or drug allergy * currently taking glucophage or glucovance (metformin) * history of chronic asthma * history of diabetes mellitus * renal (kidney) disease, or solitary kidney * recent lab tests showing elevated serum creatinine (≥ 1.5 mg/dl) * recent lab tests showing estimated glomerular filtration rate (egfr) ≤ 60 ml/minute * positive urine pregnancy test or currently breast-feeding * inability to understand the risks and benefits of the study * the standard mri contraindications apply, including but not limited to: having a pacemaker or other implanted electronic device, metal foreign bodies within the eye, aneurysm clips, heart valve prosthesis, vascular stents, coils, intrauterine devices (iuds), inferior vena cava (ivc) filters, gunshot wounds with retained bullet fragments.

Keywords: breast cancer