Kornimate/medical-research-clean huggingface dataset:
the effects of phototherapy in preterm infants pda

Conditions: Patent Ductus Arteriosus After Premature Birth; Hyper Bilirubinemia

Summary: the study was designed to assess whether chest shielding during phototherapy reduces the incidence of pda, as assessed by serial echocardiographic examinations, in a population of extremely preterm infants born at lower 30 week gestation.

phototherapy is a therapeutic intervention frequently used for management of neonatal hyperbilirubinaemia in extremely premature infants, especially in the first week when patency of the ductus is a clinical problem. phototherapy has also been implicated in increased ductal patency. one randomized, controlled trial showed that chest shielding during phototherapy reduced the incidence and severity of pda by 50% in preterm infants. these findings were mainly based on clinical evaluation of the ductus with echocardiographic studies performed only on a subgroup of infants noted to have a murmur on clinical examination.

Eligibility criteria:
inclusion criteria: * gestational week ≤ 30 weeks receiving phototherapy due to jaundice and infants who can perform echocardiography before and after treatment will be included in the study. exclusion criteria: * babies with congenital heart disease. * infants with major structural anomalies and infants who can not undergo echocardiography before or after treatment.

Keywords: chest shielding patent ductus arteriosus chest childing
surgical joint registry mbjrf

Conditions: Osteoarthritis, Knee; Osteoarthritis, Hip

Summary: the purpose of this study is to follow the patient's short term and long term clinical outcome after undergoing joint replacement surgery.

this is a registry database. consented subjects will have their medical data collected via a patient questionnaire in either paper or web based application form. data will be collected prospectively and retrospectively and will be entered into the database generated by memorial bone and joint research foundation. collection of data will start during the initial clinic visit as part of standard of care. subjects will be asked to fill out a 4-page "pre-operative hip questionnaire" or "pre-operative knee questionnaire", which includes questions for self-assessment from the hip disability and osteoarthritis outcome score (hoos), knee disability and osteoarthritis outcome score (koos), eq-5d and university of california, los angeles activity (ucla) questionnaires. demographic, intra-operative and additional data will also be collected to correctly identify the subject's specific disease process and treatment plan. subjects will be asked to fill out a post-operative hip and knee questionnaire that is similar to the pre-operative questionnaire to evaluate the improvement in their clinical outcomes. the subjects will be requested to complete the post-operative questionnaires at 6 months and annually thereafter.

Eligibility criteria:
inclusion criteria: * inclusion criteria will be limited to subjects who have consented to undergo elective total joint replacement, hip resurfacing and partial knee surgery, arthroscopy and femoro-actabular impingement (fai) release performed by the pi. * all patients of legal adult age will be eligible for the study. all patients will have an equal chance to participate in the study regardless of race or gender. patients will be enrolled in the order as they are diagnosed by the pi. exclusion criteria: * exclusion criteria will be limited to morbid obesity, active infection, heart failure, lung failure, severe bleeding abnormalities, subject with known metal allergy, subject who cannot legally decide for themselves.

Keywords: registry joint registry oa osteoarthritis osteo arthritis knee hip tka tha
application of ultra-high frequency ultrasonography (uhfus) to the study of gingival tissues

Conditions: Gingivitis; Periodontitis

Summary: gingival inflammation triggered by the accumulation of bacterial is the primary risk factor for the development of periodontitis. clinically, localized signs of inflammation limited to the gingiva, presence of significant bacterial plaque load, and stable attachment levels on the periodontium can be observed in course of gingivitis. the aim of the present study is to compare clinical aspects of gingival tissue in healthy patients versus patients with gingivitis to assess the ultrastructural variations present in course of inflammation. patients with gingivitis and healthy controls will be enrolled. all patients will undergo ultra-high frequency ultrasonographic scans (70 mhz) of gingival tissue on three areas per dental arch (anterior, middle right, middle left). gingival thickness, echogenicity, and vascularization assessed through resisitive index will be evaluated.


Eligibility criteria:
inclusion criteria: * males or females of age \> 18 years * presence of at least 20 teeth * full-mouth plaque score (fmps) \>50% * fmbs \>30% * ability and willingness to give informed consent exclusion criteria: * pregnancy or breastfeeding * pharmacological treatment with antinflammatory drugs, statins, or either local or systemic antibiotics (within the previous 30 days) * smoking habit * dental or periodontal condition requiring immediate treatment * refusal to be enrolled in the study
a clinical trial to evaluate the effectiveness and safety of xiyanping injection in the treatment of mild type of hand, foot, and mouth disease

Conditions: Hand, Foot and Mouth Disease

Summary: the aim of this study is to evaluate the effectiveness and safety of xiyanping injection for mild type of hand, foot, and mouth disease.

by adopting a multi-center, randomized and controlled clinical trial, this study is aimed to evaluate the efficacy and safety of xiyanping injection in the treatment of mild type of hand, foot and mouth disease (hfmd), and designed to combine both observational and interventional methodologies in this research.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of severe hand-foot-mouth disease patients according to hand-foot-mouth disease treatment guidelines 2010 issued by china's ministry of health; more than 1/3 patients should be diagnosed by etiological examination. * less than 48 hours of occurrence of fever and/or occurrence of tetter or herpes. * age of 1-14 years. * patients or their guardians agree to participate in this study and signed the informed consent form. exclusion criteria: * complicated with other serious primary diseases in organ such as congenital heart disease, chronic hepatitis, nephritis and blood diseases, etc. * with history of allergies on traditional chinese medicine. * patients or their guardians suffering from psychiatric diseases. * attending other clinical studies on hfmd after diagnosed.

Keywords: mild type of hand, foot and mouth disease xiyanping injection effectiveness safety
assessment of daily disposable silicone hydrogel lens wear

Conditions: Myopia

Summary: the purpose of this study is to evaluate the effect of an investigational silicone hydrogel soft contact lens on new contact lens wearers (neophytes) compared to a control of spectacle wearers.


Eligibility criteria:
inclusion criteria: * able to read, comprehend and sign an informed consent (or parental consent/subject assent, as appropriate). * willing to comply with the study visit schedule. * ages 15 to 39. * has access to a cellular telephone with text messaging capabilities. * has a current pair of spectacles. * 'neophyte' - in this work, 'neophyte' will be taken to mean any subject who has never been dispensed contact lenses. a subject who has taken part in a non-dispensing clinical study or has been fitted with contact lenses in practice but never went on to actually wear the lenses, will also be classified as a 'neophyte'. * spherical contact lens (cl) prescription between -0.75d and -6.00d and spectacle cylinder equal to or less than 0.75 dc. * monocular best-corrected distance visual acuity (va) ≥ 20/30 snellen in each eye. * subject agrees to "intent" of wearing the cls at minimum 6 hours/day for at least 4 days per week. * they agree not to participate in other clinical research during the duration of this study. exclusion criteria: * active ocular allergy, infection, injury, inflammation, or abnormality (e.g., keratoconus) that might interfere with soft contact lens wear. * prior corneal refractive surgery or corneal irregularity (e.g., keratoconus). * systemic disease, which might interfere with contact lens wear. * medication usage that may be associated with eye dryness. * use of any topical medication such as eye drops or ointment. * pregnant or lactating (by self-report). * aphakia. * grade 2 or greater of any of the following ocular surface signs: corneal edema, corneal vascularization, corneal staining, tarsal conjunctival changes or any other abnormality, which would normally contraindicate contact lens wear. * have participated in any other clinical trial or research in the two weeks prior to starting this study.
personalized treatment for refractory h pylori infection

Conditions: Helicobacter Pylori Infection

Summary: in this study, the investigators develop a personalized treatment according to culture-guided antibiotics plus high-dose proton-pump inhibitor and bismuth to treat refractory h pylori infection.

they are categorized into three groups: (1) patients who have positive result of culture with equal to or more than three susceptible antibiotics are treated by non-bismuth quadruple therapy (rabeprazole 20 mg q.d.s. and three effective antibiotics), (2) patients who have positive result of culture with one or two susceptible antibiotics are treated by bismuth-containing therapy (rabeprazole 20 mg q.d.s., bismuth subcitrate 120 mg q.d.s. and all the effective antibiotics), and (3) patients who have negative result of culture or whose culture data are unavailable will be treated by (rabeprazole 20 mg q.d.s, amoxicillin 500 mg q.d.s., tetracycline 500 mg q.d.s. and levofloxacin 500 mg o.d.) for 14 days.

Eligibility criteria:
inclusion criteria: h pylori-infected adult patients with at least two previous failed eradication attempts will be enrolled in this study after giving informed consent. * positive results of both rapid urease test and histology, * a positive result of urea breath test, * or a positive result of culture exclusion criteria: * ingestion of antibiotics, bismuth, or proton-pump inhibitor within the prior 4 weeks, * patients with allergic history to the medications used, * patients with previous gastric surgery, * the coexistence of serious concomitant illness (for example, decompensated liver cirrhosis, uremia), * pregnant women.

Keywords: helicobacter pylori third-line therapy antibiotic susceptibility eradication
in vivo optical spectroscopy monitoring in a new model of muscular compartment syndrome

Conditions: Human Volunteers

Summary: muscular compartment syndrome (mcs) is consecutive to an increase in intramuscular compartment pressures, and is a rare but serious postoperative complication. the invos (in vivo optical spectroscopy) monitors tissular oxygenation continuously and non-invasively. the objective is to develop a model mimicking the physiopathology of mcs to assess the interest of the invos in this case.

after inflation of a tourniquet (pressure equal to the mean arterial pressure, we will obtain a model of slight venous congestion and arterial hypoperfusion. a comparison will be made between invos monitoring, sensory deficits, pain, electromyography and invasive pressure.

Eligibility criteria:
inclusion criteria: * healthy volunteers * \>18yr * informed consent * male exclusion criteria: * neuropathies * vascular pathology * actual pain * anti-platelet or anticoagulant therapy * ipsilateral history of fracture

Keywords: human volunteers
predictive character analysis of ganglionic echography for the diagnostic of benin or malignant superficial adenopathy

Conditions: Superficial Adenopathy

Summary: investigators need to establish a formal diagnostic of superficial adenopathy through complementary investigations to find etiologic diagnostic ( echography, adenogram). echography examination should be a guide to take in charge the adenopathy and to predict presence of malignant (primitive) or benin (reactional) character of adenopathy. the aim of this study is to codify the management of adenopathic patient with a diagnostic in 48 hours after examination. this fast diagnostic helps to prevent unnecessary biopsy, to avoid wasting time in case of a serious pathology.


Eligibility criteria:
inclusion criteria: - superficial adenopathy exclusion criteria: - obvious adenopathy

Keywords: superficial adenopathy - echography
effects of active reminders and motivational techniques on oral hygiene and gingival health in orthodontic patients

Conditions: Oral Hygiene; White Spot Lesion; Gingivitis

Summary: this study will compare the use of text message reminders versus multiple in-person sessions of oral hygiene instructions and motivation on improving oral hygiene measurements.

orthodontic treatment (i.e. braces) makes it hard to keep good oral hygiene. the purpose of this research study is to compare the use of text message reminders versus multiple in-person sessions of oral hygiene instructions and motivation on improving oral hygiene measurements. participation in this study will last up to 6 months and will consist of 4 study visits to the vcu orthodontic clinic which are also regular visits for treatment. measurements to assess participant's oral health will be taken during these visits. participants will be randomly assigned to 1 of 4 groups which may include receiving different types of text messages, repeated in-person oral hygiene instructions, or both, or neither.

Eligibility criteria:
inclusion criteria: 1. age 11-20 that have their own mobile device 2. patients have cellular plan that allows them to receive text messages at no extra cost 3. patients that will undergo treatment with full fixed appliances exclusion criteria: 1. patients with significant medical or dental history, including patients with bleeding disorders that would require antibiotic prophylaxis 2. pregnant women
a study to estimate how often post-stroke spasticity occurs and to provide a standard guideline on the best way to monitor its development

Conditions: Spasticity as Sequela of Stroke

Summary: this study will monitor patients during the first year following their stroke. stroke is a very serious condition where there is a sudden interruption of blood flow in the brain. the main aim of the study will be to find out how many of those who experience their first-ever stroke then go on to develop spasticity that would benefit from treatment with medication. spasticity is a common post-stroke condition that causes stiff or ridged muscles. the results of this study will provide a standard guideline on the best way to monitor the development of post-stroke spasticity.


Eligibility criteria:
inclusion criteria: * participant must be aged 18 to 90 years at the time of providing informed consent * first-ever clinical stroke, defined according to world health organization criteria as rapidly developing clinical signs of focal (at times global) disturbance of cerebral function lasting more than 24 hours, within the past 4 weeks; * confirmed paresis of the arms and/or legs which does not resolve within 1 day, according to the nihss score (a score of \> 0 on question 5 or 6 of the scale) within 2 weeks after the stroke * capable of giving informed consent which includes compliance with the requirements and restrictions listed in the icf and in this protocol exclusion criteria: * upper or lower extremity functional impairment prior to stroke per investigator judgement (e.g., modified rankin scale \>2); * presence of significant/major neurological impairment that might affect muscle tone (other than limb paresis); * severe multi-impairment or diminished physical condition before stroke that could have caused paresis/spasticity/motor deficit per investigator judgement; * life expectancy of less than 12 months as a result of severity of stroke or other illnesses (e.g. cardiac disease, malignancy, etc.) * participation in any interventional study
compare wound sampling methods efficacy in microbiology culture

Conditions: Microbial Colonization; Infected Wound; Slough

Summary: slough was a visible indicator of biofilm, which was the most available specimen from acute and chronic wounds. however, studies believed that slough were poorly accurate, and that the levine swab was more recommended for sampling bacterial culture. this study aimed to compare slough with swab sample and analyze the consistency.


Eligibility criteria:
inclusion criteria: 1. patients with acute and chronic wounds who were first seen at the wound care centre of peking university third hospital from october 2022 to october 2023; 2. patients who have followed the wound sample collection sop to simultaneously take wound swabs and putrefactive samples and send them for bacterial culture;; 3. patients aged 18 years or older; exclusion criteria: 1. patients who had been taken only one of the wound samples, either swab or slough; 2. the swab collection did not meet the deifinitions for the exudate method or the levine technique； 3. bacterial culture profile was incomplete didn't meet the requirement of the trial.

Keywords: microbial colonization infected wound slough biofilm sampling
deep learning-based classification and prediction of radiation dermatitis in head and neck patients

Conditions: Radiation Dermatitis; Head and Neck Cancer

Summary: to develop a deep learning-based model to grade the severity of radiation dermatitis (rd) and predict the severity of radiation dermatitis in patients with head and neck cancer undergoing radiotherapy, so as to provide support for doctors' diagnosis and prediction.

1. image acquisition the images of the neck area were collected from the enrolled patients one week before and every week during radiotherapy. the photographs were taken from three angles (front, left and right oblique) of the neck area. 2. grading evaluation each image was individually graded by three experienced radiotherapy experts according to the rd criteria of rtog 3. data analysis construct a dermatitis grading model basing on deep learning. evaluate the performance of model using accuracy, precision, recall, f1-measure, dice value.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old. * histologically or cytologically confirmed head and neck carcinoma confirmed by pathology. * receive radical radiotherapy including neck area * informed consent. exclusion criteria: * unable to cooperate with image acquisition
effect of ectoine after photorefractive keratectomy (prk).

Conditions: Photorefractive Keratectomy; Corneal Haze

Summary: this is a comparative, open label, parallel group, non interventional study aims to assess the effect of ectoine containing eye drops on stromal haze, pain and epithelial healing after photorefractive keratectomy (prk). the patient apply ectohylo eye drops (ectoine +sodium hyauronate) in the right eye and polyfresh extra eye drops (carboxymethyl cellulose + sodium hyauronate ) in the left eye plus the routine post prk treatment in both eyes. post operative pain , epithelial healing and corneal densitometry is observed in both eyes.

photorefractive keratectomy (prk) is a commonly used operation for laser vision correction. the main fears of this type of laser vision correction is corneal haze, delayed epithelial healing and postoperative severe pain. ectoine is a natural compound that has the ability to protect biological membranes from damage and environmental effects. this study assess the use of ectoine containing eye drops to protect the bare ocular surface and reduce inflammation after prk that will inturn is expected to affect the post operative corneal haze, pain, and epithelial healing .

Eligibility criteria:
inclusion criteria: * patient undergoing prk for myopia and myopic astigmatism when astigmatism is 2.5 diopters or less and myopia with spherical equivalent -4 or less. exclusion criteria: * patient spherical equivalent more myopic than -4 diopters * patients with astigmatism more than 2.5 diopter * patients with anisometropia ( difference \> 2 diopters) * patient with previous ocular surgery * patients with chronic systemic disease that can affect results of laser vision correction (e.g. rheumatoid arthritis) * pregnant and lactating females

Keywords: prk, surface ablation, corneal haze
this study will evaluate the effectiveness of ntx-001, a surgical nerve repair product when used in people with upper extremity nerve lacerations.

Conditions: Peripheral Nerve Injury Upper Limb; Peripheral Nerve Injury (PNI)

Summary: ntx-001 is a single use surgical product intended for use in conjunction with standard suture neurorrhaphy of severed nerves in patients between 18 and 80.

ntx-001 has been developed as a surgical product to be used in conjunction with standard suture neurorrhaphy of a severed nerve. use of ntx-001 is intended to safely accelerate the often slow and diminished return of function in repaired nerves. it often takes months and/or years to determine if function will be restored. by that point, restoration is often incomplete and can result in lifelong motor and/or sensory deficits. by reconnecting (peg-fusion) a substantial number of axons within a severed nerve, the degeneration-regeneration cycle and subsequent atrophy may be reduced or even prevented for those axons and their targets, respectively. ntx-001 (peg-fusion) has the potential to avoid the consequences of protracted denervation of distal target tissues by eliminating the period of total denervation thus reducing the time to stable recovery and providing greater innervation to affected tissues.

Eligibility criteria:
inclusion criteria: * the subject has voluntarily agreed to participate in this study and has signed an institutional review board (irb) approved informed consent form. * the subject is between eighteen (18) and eighty (80) years of age. * the subject has clinical evidence of a sunderland's 4th degree (class ii) or 5th degree (class iii) nerve transection(s) that has resulted in upper extremity nerve impairment that requires surgical treatment. exclusion criteria: * subjects whose nerve repair will occur greater than 48 hours after nerve transection. * subjects requiring nerve repair involving an autograft, allograft or conduit(s). * subjects with multiple transected nerve injuries are allowed into the study only if all injuries are amenable to direct repair. * subjects who, in the judgement of the investigator, are not likely to demonstrate meaningful recovery within a reasonable time frame during follow up due to significant muscle atrophy or other morbidity. * the subject's injury is a result of a suicide attempt or self- harm. * the subject has documented history or clinical signs of any condition where ntx-001 might not prove beneficial (e.g., systemic neuromuscular disease, systemic neurological deficit, or other treatments known to affect the growth and/or physiology of the neural and vascular system). * the subject has a known allergy to polyethylene glycol (peg) or human grade silicone. * the subject is pregnant or breastfeeding. * the subject is currently enrolled in another investigational study or has participated in an investigational study within 30 days prior to screening.

Keywords: transected nerves requiring surgical repair upper extremity