Kornimate/medical-research-clean huggingface dataset:
early detection of pancreatic cystic neoplasms

Conditions: Pancreatic Cysts; Intraductal Papillary Mucinous Neoplasm; Pancreatic Mucinous-Cystic Neoplasm; Cystic, Mucinous and/or Serous Neoplasm; Solid Pseudopapillary Tumour of the Pancreas

Summary: this research is being done to learn more about pancreatic cysts. the tests that are currently available are imperfect at determining exactly what type of pancreatic cyst a person has, which cysts contain cancer, or what the risk is of developing cancer in the future. the aim of this study is to use a combination of clinical, imaging, cyst fluid analysis, and molecular markers to try to help develop better tools to answer these questions.

incidental pancreatic cysts are increasingly recognized due to the widespread use of cross-sectional imaging techniques such as ct and mri. a number of lesions in the pancreas can form cysts, including serous cystadenomas (sca), mucinous cystic neoplasms (mcns), intraductal papillary mucinous neoplasms (ipmns), solid-pseudopapillary neoplasms (spns), and pseudocysts. scas and pseudocysts are considered benign; whereas spns are considered malignant and require surgical resection. ipmns and mcns are considered neoplasms with malignant potential, although the exact risk of malignant progression of these cysts is unknown. currently, mcn are all surgically resected, whereas ipmn are resected if they have features suspicious for malignancy. however, current diagnostic tests cannot always reliably distinguish harmless from potentially harmful cysts. recent studies conducted at johns hopkins have shown that each cyst type has unique genetic features that could be used as diagnostic biomarkers. in this study, clinical, imaging data and cyst fluid analysis of individuals with pancreatic cysts will be collected. in patients who undergo an endoscopic ultrasound (eus) procedure, if a fine needle aspiration (eus-fna) is performed, and there is extra cyst fluid left after standard clinical tests have been sent, the extra cyst fluid will be submitted for molecular marker analysis. if an individual undergoes surgery to remove the cyst, cyst fluid will be collected after the cyst has been removed. in addition, a small amount of blood will be collected at the time of the eus or surgical procedure. aims: the general aim is to propose and prospectively validate a diagnostic approach and model for prediction of mucinous versus non-mucinous, and malignant versus non-malignant, pancreatic cysts using a combination of clinical, radiologic, and biomarker characteristics.

Eligibility criteria:
inclusion criteria: * adult patients age 18 years and older with pancreatic cyst. exclusion criteria: * individuals with asa class 4 or greater. * inability to provide informed consent. * pregnancy or lactation.

Keywords: pancreatic cyst ipmn sca spn mcn pancreatic cystic neoplasm
modified early warning score (mews) and quick sequential organ failure assessment (qsofa) in the emergency room

Conditions: Sepsis

Summary: in the development of sepsis treatment of recent years, the demand for medical manpower has increased significantly when patients with sepsis appear because of the expansion of medical care demand and shortened response time related to sepsis due to the shortage of manpower, a more simple and easy-to-operate inspection method is adopted and artificial intelligence technology is used to assist in the evaluation. the applicability of physiological indicators mews and qsofa as sepsis screening tools in emergency department (ed) and predicting sepsis outcome in the emergency department. when patients with sepsis appear, artificial intelligence technology is used to remind the physicians to respond and administer drugs as soon as possible. this is a single-center retrospective study of a group of patients admitted to the emergency department. the medical records were reviewed, mainly based on the hospital site records and the existing vital signs of the patients. attended a hospital emergency room between january 2020 and december 2022. physiological numerical indicators mews and qsofa were all scored to understand the distribution of sepsis.

1. a single-center retrospective study of a cohort of patients admitted to the emergency department 2. to see a doctor in the emergency department of the hospital between january 2020 and december 2022, review their medical records, and focus on the hospital's on-site records and the existing patient's vital signs. 3. the physiological indicators mews and qsofa were scored to understand the distribution of sepsis. 4. remind the doctor when a suspected sepsis patient appears under level 5 triage and use artificial intelligence technology to assist 5. this study will explore the specific improvement practices and effects of improving the response of patients with sepsis when they see a doctor 6. to analyze and evaluate the economics and benefits of this operation mode, improve the accuracy of emergency inspection of sepsis patients and improve the rationality of hospital manpower deployment 7. scheduled progress of the plan: patients who visited the emergency department of the hospital between january 2020 and december 2022 were included in this study under investigation. this is a retrospective study, and patients are required to undergo necessary examinations according to their own conditions, without any interference from the study

Eligibility criteria:
inclusion criteria: * this is a single-center retrospective study of a group of patients admitted to the emergency department. exclusion criteria: * patients with incomplete treatment clinical data, lack of information in medical records, trauma patients

Keywords: sepsis modified early warning score(mews) quick sequential organ failure assessment(qsofa) emergency medicine
temporomandibular bioviscosuplementation (platelet-rich plasma combined with hyaluronic acid) after double-puncture arthrocentesis: a randomized controlled trial

Conditions: Temporomandibular Joint Disorders

Summary: intra-articular injections of hyaluronic acid (ha) or platelet-rich plasma (prp) have been used with temporomandibular joint (tmj) arthrocentesis to improve lubricative properties and influence regenerative processes. a randomized, controlled clinical trial investigated the benefits of complementary bioviscosuplementation (ha+prp) in patients submitted to double-portal tmj arthrocentesis.


Eligibility criteria:
inclusion criteria: * (1) age \>18 years; (2) history of conservative treatment for tmd without significant improvement for at least three months; (3) clinical diagnosis of unilateral or bilateral intra-articular disorder; (3) clinical criteria for unilateral or bilateral tmj arthrocentesis; (4) magnetic resonance imaging (mri) and computed tomography (ct) documenting arthrogenous derangement. exclusion criteria: * the exclusion criteria included: 1) any history of previous tmj surgical intervention or any facial trauma within the last 4 weeks before the study; 2) concomitant other contralateral tmj surgery; 3) severe medical problems or mental illness and pregnancy.

Keywords: hyaluronic acid platelet-rich plasma arthrocentesis viscosuplementation
assessment of sleep complaints in brain tumor survivors

Conditions: Brain Tumors

Summary: survivors of pediatric brain tumors are noted to have increased rates of excessive daytime sleepiness. however, very little data are available regarding the specific sleep disturbances of pediatric brain tumor survivors. children ages 8 to 18 years of age who are at least 5 years from diagnosis and at least 2 years post treatment or observation only for a brain tumor will be targeted to assess the prevalence of sleep complaints. the study focuses on the following objectives: * to estimate sleep disturbance in a cohort of pediatric brain tumor survivors. * estimate the rates of parent- and self-reported excessive daytime sleepiness in pediatric brain tumors * estimate the rates of parent-reported sleep-disordered breathing, including snoring and witnessed apneas, in pediatric brain tumor survivors * estimate the rates of parent- and self-reported behavioral sleep problems, including nocturnal enuresis, bedtime resistance, nighttime awakenings, nightmares, and fatigue in pediatric brain tumor survivors. the study focuses on the following secondary objectives: * to describe bedtime patterns and sleep hygiene of pediatric brain tumor survivors. * estimate the typical parent- and self-reported weekday sleep duration of pediatric brain tumor survivors * estimate the typical parent- and self-reported weekend sleep duration of pediatric brain tumor survivors and if it differs from the weekday sleep duration * estimate the typical parent- and self-reported consistency of sleep hygiene in pediatric brain tumor survivors

this non-therapeutic single arm study will characterize the prevalence and types of sleep complaints of pediatric brain tumor survivors. brain tumor survivors ages 8 to 18 years who are at least 5 years post diagnosis and 2 years post active therapy and their parents/guardians will be approached to participate during clinic visits. if the patient and guardian agree to participate, they will be administered three questionnaires in the clinic during the patient's visit. from the medical record, the following variables will be utilized to characterize the subjects and estimate which groups are at greatest risk of sleep disturbances: * specific brain tumor diagnosis * location of tumor (cerebral hemispheres, parasellar region, posterior fossa, or spine) * age at diagnosis * obesity status * treatment modality (surgery, radiation therapy, and/or chemotherapy vs. observation only)

Eligibility criteria:
inclusion criteria: * age ≥8 to ≤ 18 years of age * brain tumor survivor * ≥5 years post diagnosis * ≥2 years post active cancer-directed therapy or observation only * parents speak and read english fluently * potential participant reads english fluently * potential participant/guardian willing to sign consent exclusion criteria: * survivor of any cancer other than a brain tumor.

Keywords: sleep complaints brain tumor survivors
study of car-t therapy in older patients

Conditions: Lymphoma; Refractory B-Cell Lymphoma; Lymphoma, B-Cell; DLBCL NOS; High-grade B-cell Lymphoma; Multiple Myeloma

Summary: this study is being done to find out how older patients respond to car-t cell therapy and how the treatment affects their quality of life. this is a quality of life study and participating in the study does not involve receiving any treatment, other than the standard treatment for participants' disease.


Eligibility criteria:
inclusion criteria: * are ≥60 years old (all cohorts) * have pathologically confirmed, relapsed refractory lymphoid malignancy or plasma cell disorder receiving a commercial car t-cell product (all cohorts) * able to speak and understand english (cohort 1 and 4 only) * have a moca score of less than 26 out of 30 during the ga visit by a geriatrician prior to car t-cell treatment (cohort 4 only) exclusion criteria: * any prior commercial or investigational car t therapy (all cohorts) * current diagnosis of major axis i psychiatric disorder (dsm-iv), major depression, bipolar disorder, or schizophrenia, as per medical records or patient report (cohort 1 only) * history of a neurological disorder, neurodegenerative disease, or traumatic brain injury with loss of consciousness (\>60 minutes), as per medical records or patient report (cohort 1 only) * current ongoing substance abuse and/or history of substance abuse, as per medical records or patient report (cohort 1 only) * history of cns disease (cohort 4 only)

Keywords: lymphoma cart therapy relapsed refractory large b-cell lymphoma high-grade b-cell lymphoma dlbcl nos refractory b-cell lymphoma 19-452 memorial sloan kettering cancer center
next generation sequencing method for the detection of egfr gene mutations in the plasma of patients with lung cancer

Conditions: Carcinoma, Non-small Cell Lung Cancer (NSCLC)

Summary: the study aims to evaluate the plasma-seqsensei™ solid cancer ivd kit ngs diagnostic test (sysmex) before its introduction into routine diagnostics. this is a test for research of egfr mutations in cfdna that needs to be evaluated in a patient population with lung adenocarcinoma already characterized for egfr mutations by a molecular test of reference. the proposed study does not present any risk to participants.


Eligibility criteria:
inclusion criteria: * males or females aged at least 18 years; * patients with advanced or metastatic non-small cell lung cancer at diagnosis or progression who have previously had the cobas® egfr mutation test v2 (roche) performed on a liquid biopsy with a valid result (positive or negative); * availability of 6 ml of plasma. exclusion criteria: * plasma not available in sufficient quantities to perform both tests; * cobas test with invalid result.

Keywords: lung cancer non-small cell lung cancer egfr mutation next generation sequencing plasma
modulation effect of tacs on chronic low back pain

Conditions: Chronic Low-back Pain

Summary: investigating the modulation effect of tacs

investigating the modulation effect of one-month transcranial alternating current stimulation (tacs) for low back pain

Eligibility criteria:
inclusion criteria: 1. volunteers 18-60 years of age 2. meet the classification criteria of the chronic lbp (having low back pain for more than 6 months) 3. at least 4/10 clinical pain on the 0-10 lbp nrs 4. at least a 10th grade english-reading level; english can be a second language provided that the patients understand all questions used in the assessment measures 5. meeting the mri / meg / eeg screening criteria exclusion criteria: 1. specific causes of back pain (eg, cancer, fractures, spinal stenosis, infections) 2. complicated back problems (eg, prior back surgery, medicolegal issues) 3. the intent to undergo surgery during the time of involvement in the study 4. history of cardiac, respiratory, or nervous system disease that, in the investigator's judgment, precludes participation in the study because of a heightened potential for adverse outcome (for example: asthma or claustrophobia) 5. presence of any contraindications to mri scanning (for example: cardiac pacemaker, metal implants, claustrophobia, pregnancy, cannot lie still in fmri scanner) 6. concomitant autoimmune, chronic, inflammatory, neoplastic, and psychiatric diseases 7. pregnant or lactating 8. conditions making study participation difficult (e.g., paralysis, psychoses, or other severe psychological problems as per the judgment of a study investigator during session 1) 9. active substance abuse disorders (based on subject self-report and drug test) 10. regular use of pain medication such as opioids, nonopioid analgesics, coanalgesics, corticosteroids, or immunomodulatory agents 11. any medical conditions, such as peripheral neuropathy, that could affect the results of qst 12. current use of psychotropic medication
the impact of salpingectomy and single dose systemic methotrexate treatments on ovarian reserve in ectopic pregnancy

Conditions: Ectopic Pregnancy; Infertility

Summary: the investigators aimed to investigate the effects of salpingectomy and methotrexate administration on ovarian reserve in ectopic pregnancy.

in this study, the effects of unilateral laparoscopic salpingectomy and single dose of systemic methotrexate administration on ovarian reserve in patients diagnosed with ectopic pregnancy were investigated.

Eligibility criteria:
inclusion criteria: * ectopic pregnancy diagnosis exclusion criteria: * history of endometriosis, ovarian surgery, systemic chemotherapy, art treatment. * patients treated with multiple doses of methotrexate or different surgical procedure (salpingostomy, milking)

Keywords: ectopic pregnancy ovarian reserve salpingectomy methotrexate
improving care for women with urinary incontinence (empower)

Conditions: Urinary Incontinence

Summary: the overall goal is to improve diagnosis and non-operative management of urinary incontinence in women.

in the study, patients will be screened in primary care offices for symptoms of urinary incontinence. women with positive screening results will be asked if they are interested in participating in an implementation study where women will be assigned to one of the three following groups: 1. usual care plus patient educational opportunities - the patient's urinary incontinence will be managed using standard of care treatment by the patient's primary care provider. patients will be offered educational opportunities about urinary incontinence. 2. nurse navigation - along with the treatment described for "usual care plus patient educational opportunities," a nurse navigator will work with the patient to implement behavioral changes and provide education and physical therapy options. in addition, the navigator will be available to answer the patient's questions in a timely fashion and help the patient move through the care pathway. 3. nurse navigation and chatbot - along with the treatment described for "usual care plus patient educational opportunities" and "nurse navigation," this group will include a chatbot feature which will allow a patient to directly and privately communicate with an artificial intelligence-driven chatbot, also known as a "conversational agent," that will provide education and help the patient navigate the care pathway. all participants will complete questionnaires throughout their enrollment and data will be collected from medical records. the study team will analyze the data at six months after the original appointment/study enrollment, assess adherence to therapy and how the therapy impacted the outcomes the team hopes to improve, such as improvement in symptoms. the study will be implemented over three subsequent time periods called wave 1, wave 2 and wave 3 with primary care practices from two geographic regions being involved in each wave (6 regions total). participants in wave 1 will be followed for a total of 18 months, while participants in wave 2 will be followed for a total of 12 months, and participants in wave 3 will be followed for 6 months. primary care providers at all participating practices will be offered educational opportunities related to urinary incontinence.

Eligibility criteria:
inclusion criteria: 1. female patient having a primary care provider visit at university hospitals (uh) cleveland primary care institute (pci) 2. ≥ 18 years old 3. scores 1 or higher on the international consultation on incontinence questionnaire-urinary incontinence short form (iciq-sf) exclusion criteria: none

Keywords: women female urinary incontinence empowering empower providers bladder leakage incontinence
sportcheck follow-up

Conditions: Cardiovascular Diseases; Childhood Obesity; Hypertension

Summary: the study resembles a four-year follow-up on the influence of physical activity and fitness, blood pressure, bmi and stress on vascular health in primary schoolchildren. it examines the predictive value of retinal vessel diameters for the development of childhood hypertension.

the study aims to examine the usefulness of retinal vessel analysis in childhood cardiovascular prevention. it investigates the long-term influence of physical activity and fitness on retinal vessel diameters, blood pressure, bmi and psychosocial stress in children. the study aims to set new standards for an integrative primary prevention concept to initiate healthy ageing from childhood to adulthood.

Eligibility criteria:
inclusion criteria: * all fifth-graders of public primary schools in basel-stadt with an informed consent signed by their parents are included. exclusion criteria: * fifth-graders with motor-or other disabilities that do not allow participation will be excluded.

Keywords: retinal vessels physical activity children psychosocial health
evaluation of efficacy and safety of vardenafil in patients with erectile dysfunction and type 1 diabetes

Conditions: Erectile Dysfunction

Summary: asses efficacy of vardenafil in patients with type 1 diabetes and erectile dysfunction


Eligibility criteria:
inclusion criteria: * men \>/= 18 years of age, with 6 months or longer diagnosis of ed as defined by nih consensus statement, * diabetes type 1 * stable sexual relationship for \> 6 month. exclusion criteria: * primary hypoactive sexual desire * history of myocardial infarction, stroke or life-threatening arrhythmia within prior 6 month * nitrate therapy

Keywords: erectile dysfunction diabetes mellitus type 1 vardenafil
incidence of different surgical technics for colorectal deep infiltrating endometriosis on the post-operative fertility and pregnancy outcomes

Conditions: Endometriosis

Summary: endometriosis is a disease that is very present on the current media scene. its symptoms are very nonspecific and numerous. (dysmenorrhea, dyspareunia, dyschezia, urinary functional signs, infertility, chronic pelvic pain, etc.) its prevalence is estimated at 10% of women and 20% of them have deep pelvic endometriosis. colorectal lesions involving the rectosigmoid junction and the rectum represent the most severe forms and affect 5.3 to 12% of patients with deep pelvic endometriosis. endometriosis is found in 20 to 50% of patients consulting for infertility and the rate of spontaneous pregnancy in patients with deep endometriosis is estimated to be between 8.7 and 13%. surgery appears to improve fertility in women. however, several surgical techniques for deep endometriosis at the digestive level have been described, conservative or radical, without any having demonstrated its superiority both in terms of symptoms and fertility. the aim of this study was to evaluate the incidence of different surgical technics (shaving vs. bowel resection) on post-operative fertility among patients with bowel deep infiltrating endometriosis and the pregnancy outcome


Eligibility criteria:
inclusion criteria: * adult woman (≥18 years old). * woman with a desire to become pregnant and who had undergone surgery for the management of deep digestive endometriosis between september 01, 2009 and october 31, 2016. * woman who has not expressed, after information, the reuse of her data for the purposes of this research. exclusion criteria: * woman who expressed her opposition to participating in the study * woman who had undergone a surgical intervention for the management of deep digestive endometriosis between september 01, 2009 and october 31, 2016 and having no desire to become pregnant * woman under safeguard of justice * woman under guardianship or guardianship

Keywords: colorectal endometriosis deep infiltrating endometriosis fertility surgical technics in endometriosis
open-label extension study for patients who completed a phase 3 double-blind study of peg-uricase for symptomatic gout

Conditions: Gout

Summary: this is an open-label extension phase of two double-blind, placebo-controled phase 3 protocols evaluating peg-uricase in the treatment of hyperuricemic subjects with symptomatic gout. the purpose of this study is to provide a continuation of treatment to subjects completing the double-blind studies and obtain long-term safety and efficacy data.


Eligibility criteria:
inclusion criteria: * completed treatment in one of two double-blind, placebo controlled studies of peg-uricase in subjects with hyperuricemia and symptomatic gout exclusion criteria: * unstable angina * uncontrolled arrhythmia * uncontrolled hypertension * end stage renal disease requiring dialysis * anemia

Keywords: gout chronic gout