Kornimate/medical-research-clean huggingface dataset:
pneumatic leg compression and norepinephrine requirements in patients having non-cardiac surgery

Conditions: Hypotension During Surgery

Summary: the plane trial is a randomized, single-center trial investigating whether pneumatic leg compression reduces the amount of norepinephrine needed to keep map above 65mmhg compared to routine care without plc in patients having non-cardiac surgery under general anesthesia


Eligibility criteria:
inclusion criteria: consenting patients ≥45 years scheduled for elective non-cardiac surgery under general anesthesia that is expected to last ≥60 minutes exclusion criteria: patients with the following exclusion criteria: * surgery in which pneumatic calve compression is indicated according to eras guidelines * surgery which interferes with the installation or correct function of plc * sepsis (according to current sepsis-3 definition) * pregnancy * congestive heart failure nyha iii/iv * american society of anesthesiologists (asa) physical status classification v or vi * interference of plc and patient positioning (e.g.; extreme trendelenburg positioning, lithotomy positioning) * contraindications for the use of plc according to the german guideline13 (e.g., extensive thrombophlebitis, thrombosis or suspected thrombosis of the lower limbs, erysipelas, acute phlegmon, limb compartment syndrome, severe uncontrolled arterial hypertension, lymphatic drainage disorder proximal to plc, extensive open soft tissue trauma, autoimmune blistering skin conditions such as iga bullous dermatosis or bullous pemphigoid)

Keywords: stressed volume vasopressor
effects of semi-standarized acupuncture in chronical symptomatic osteoarthritis of the knee through: a randomized controlled trial

Conditions: Osteoarthritis, Knee

Summary: introduction: knee osteoarthritis is a long-term rheumatic disease with a significant impact on the patient's quality of life and the socio-economic development of societies. the usual treatment consists of non-steroidal anti-inflammatory drugs as a palliative measure. the decrease in the beneficial effect and the appearance of serious long-term adverse effects make it necessary to look for other therapeutic procedures. acupuncture is a non-pharmacological treatment that could reduce pain and improve functionality in this condition, however current scientific evidence is limited. a previous study has observed a clinical improvement in the combination of sensitized local and peripheral points in the treatment of knee osteoarthritis but studies with a larger sample are needed to confirm these results. objective: assess the effectiveness of acupuncture using a combination of local and peripheral sensitized points in the treatment of active knee osteoarthritis. methods: a randomized clinical trial will be performed in a hospital centre with 2 groups. the control group will standard treatment plus transcutaneous electrical nerve stimulation, while the intervention group will receive acupuncture in addition to standard care. study outcomes will be pain, quality of life, function, exercise adherence, drug intake, adverse effects, and body mass index. there will be a 12-month post-intervention follow-up.


Eligibility criteria:
inclusion criteria: * usual painful episode of 3 months or more * morning stiffness of 15 minutes or more * pain equal to or greater than 5 on the vas * grade 2 or greater on the kellgren-lawrence scale exclusion criteria: * corticosteroid infiltration in the 3 months prior to recruitment * rehabilitation treatment one month prior to recruitment * with a knee prosthesis * needle phobia * pregnancy * with pacemakers * cardiac arrhythmias

Keywords: acupuncture osteoarthritis, knee
proalgazyme novel algae infusion: applications in immunodeficiency

Conditions: HIV Infections; Hepatitis B; Dyslipidemia

Summary: the purpose of this study is to determine the safety and effects in hiv patients of supplementation (4-20 fl. oz. daily) with proalgazyme, a novel fermentation product of a freshwater algae ecosystem, on markers of immune status, dyslipidemia, inflammation and oxidative stress alone or in combination with haart (highly-active antiretroviral therapy).

hiv infection and interventions such as haart (highly-active antiretroviral therapy) are associated with dyslipidemia and increased markers of inflammatory and oxidative stress. these effects can hasten the progression towards aids and present serious cardiovascular complications. therapeutic agents that can provide immune support with minimal side effects and/or reduce the adverse effects of haart are in high demand worldwide. such agents may help hiv patients to live a better quality of life, and may potentially improve the compliance with traditional therapies including haart. this study is a single-center open-label design to evaluate the safety of proalgazyme novel algae infusion and its effects in varying dosages on markers of immune status, dyslipidemia, inflammation and oxidative stress in patients with hiv or hiv/hbv co-infection, who may also be taking haart.

Eligibility criteria:
inclusion criteria: * diagnosed as hiv +ve or hiv/hbv +ve * either/or: * had not taken antiretroviral drugs before (pre-haart patients) * were treated with triple drug therapy for at least 3-6 months exclusion criteria: * obese * taking any cholesterol-lowering medications 30 days prior to the start of enrollment and during the course of the study. * enrolled in another clinical study in the past 6 months.

Keywords: proalgazyme hiv haart hscrp oxidative stress cd4+ lymphocytes algae haart adverse effects hbv
clinical pregnancies after cryopreservation of donor oocytes with an open or closed device

Conditions: Infertility

Summary: this randomized pilot study will assess if there is a difference in clinical pregnancies using donor oocytes cryopreserved in either a closed or a semi-closed vitrification device.

oocyte cryopreservation was optimized by the use of a new technique: vitrification. vitrification can be performed using either open devices (where the oocytes are in direct contact with the liquid nitrogen) or closed systems (where the oocytes are never in contact with liquid nitrogen). previous studies have associated the use of open devices to higher oocyte survival rates and better embryo development. however, any beneficial effect on clinical pregnancy rates is yet to be proven. hence, the objective of this study is to compare the clinical pregnancy rates of open and closed oocyte vitrification devices.

Eligibility criteria:
inclusion criteria: * this is a pragmatic randomized clinical trial. hence, all consenting oocyte recipients will be eligible for the study exclusion criteria: * women who do not consent or that cannot comprehend the investigational nature of the study

Keywords: oocyte cryopreservation closed vitrification open vitrification
photodynamic therapy (pdt) versus transpupillary thermotherapy (ttt) in occult choroidal neovascularization (cnv) in age-related macular degeneration (amd)

Conditions: Age-Related Macular Degeneration

Summary: the purpose of this study is to compare the effect of pdt and ttt for the treatment of subfoveal occult cnv in age-related macular degeneration.


Eligibility criteria:
inclusion criteria: * \> 55 years of age, * subfoveal occult only cnv due to amd, * \ 4 disc areas * va \< 0.4 exclusion criteria: * sign of classic cnv, * cnv in other diagnoses than amd,
pet/ct based radiomics for lung cancer (perl)

Conditions: Lung Cancer

Summary: the investigators investigate the utility of fdg pet/ct based radiomics in lung cancer, including diagnosis and prognosis.

recent studies have shown that, in addition to inter-tumor heterogeneity, tumors often display startling intratumoral heterogeneity in various features including histology, gene expression, genotype, and metastatic and proliferative potential, which is often associated with adverse tumor biology. unfortunately, it is difficult to assess intratumoral heterogeneity with random sampling or biopsy as this does not represent the full extent of phenotypic or genetic variation within a tumor. given the limitations of current biopsy strategies, there is an important potential for medical imaging, which has the ability to capture intratumoral heterogeneity in a non-invasive way. borrowed from the concept in genomics and/or proteomics, radiomics was specifically proposed for medical or radiological images. it is a promising technique for improving diagnosis, staging, prognosis, treatment response prediction and potentially allowing personalization of cancer treatment. it is a process of extraction and analysis of high-dimensional image features from radiological images obtained with ct, mr or pet, which could be either qualitative or quantitative. the basic assumption of radiomics is that tumor biology could be captured by radiomic features . the purpose of this study is to investigate the utility of fdg pet/ct based radiomics in lung cancer. four pet/ct centers will be involved in this study, in which more than 1000 patients diagnosed as lung cancer will be retrospectively enrolled.

Eligibility criteria:
inclusion criteria: - all patients diagnosed as lung cancer patients who had a fdg pet/ct scan before treatment between 1 jan, 2013 and 30 december, 2016 in the four collaborative hospitals. exclusion criteria: - the patient without follow-up information

Keywords: lung cancer, fdg, pet/ct, radiomics
comparison of two norepinephrine bolus doses for management of post-spinal hypotension during cesarean delivery

Conditions: Cesarean Section Complications; Spinal Anesthetic Toxicity

Summary: in this study the investigators will compare two doses of norepinephrine bolus (6 mcg and 10 mcg) in management of maternal hypotensive episode after subarachnoid block during cesarean delivery.

maternal hypotension after subarachnoid block is a frequent and deleterious complication during cesarean delivery. although prophylaxis against hypotension using vasopressors had become a standard recommendation; the incidence of hypotension is still ∼ 20% . thus; management of maternal hypotension using vasopressor boluses is usually needed . the commonly used vasopressors during cesarean delivery are ephedrine, phenylephrine, and recently norepinephrine. the use of ephedrine is usually accompanied with maternal tachycardia and fetal acidosis. phenylephrine had been the first line for prevention and management of maternal hypotension; however, its use might result in bradycardia and decreased maternal cardiac output . norepinephrine is an alpha adrenergic agonist with weak beta adrenergic agonistic activity; thus, it does not cause significant cardiac depression as phenylephrine does. norepinephrine was introduced for use during cesarean delivery with promising results . few previous studies investigated the efficacy of norepinephrine infusion for prevention of maternal hypotension. a dose-response study had investigated the best dose of norepinephrine for prevention of maternal hypotension. in the aforementioned dose-response study, a dose of 6 mcg was reported as the best dose for prophylaxis against maternal hypotension. no studies had investigated the best bolus dose of norepinephrine for management of a maternal hypotensive episode. in this study the investigators will investigate the efficacy and side effects of two doses of norepinephrine bolus doses (6 mcg and 10 mcg) in management of maternal hypotensive episode after subarachnoid block during cesarean delivery.

Eligibility criteria:
inclusion criteria: * pregnant women * scheduled for cesarean delivery exclusion criteria: * patients with severe cardiac dysfunction * patients with low blood pressure * patients with ante-partum bleeding
prospective, long-term evaluation of the sapien 3 ultra resilia valve

Conditions: Transcatheter Aortic Valve Replacement (TAVR); Aortic-Stenosis; Aortic Insufficiency; Degenerative Valve Disease

Summary: evaluation of clinical outcomes and valve performance of the sapien 3 ultra resilia (s3ur) valve over 10 years.

transcatheter aortic valve replacement (tavr) has become the gold standard treatment for moderate-to-high risk elderly patients with severe symptomatic aortic stenosis. based on the results of randomized trials including low-risk patients, this treatment has been progressively applied to younger (in the sixties and seventies) patients with a low co-morbidity burden. life expectancy in this group is expected to extend beyond 5 years from intervention in the vast majority of patients and beyond 10 years in a high proportion. thus, the issue of valve durability has become one of the most important aspects in the tavr field in recent years. to date, the rates of bioprosthetic valve failure at 8-10 years after tavr have been systematically \<10% in all studies, but some studies have shown some degree of valve structural degeneration in close to one-third of the patients at 8-year follow-up . this subclinical valve degeneration before the 10-year follow-up landmark would represent the initial step in the process of bioprosthetic valve failure, and further valve degeneration leading to clinical symptoms is likely to occur in a significant proportion of these cases. thus, the objective of this stufy is to evaluate the valve hemodynamics of the sapien 3 ultra resilia valve (s3ur) over a long-time period.

Eligibility criteria:
inclusion criteria: 1. patients with severe aortic stenosis undergoing transfemoral tavi with s3ur valve 2. successful implantation of the s3ur valve 3. varc-3 defined technical succes is defined as: * freedom from mortality * successful access, delivery of the device, and retrieval of the delivery system * correct positioning of a single prosthetic heart valve into the proper anatomical location * freedom from surgery or intervention related to the device ( exluding permanent pacemaker) or to a major vascular or access related, or cardiac structural complication exclusion criteria: -

Keywords: tavr sapien 3 ultra resilia valve s3ur
retrospective study of patient surveys

Conditions: Body Fat Disorder

Summary: to collect data from allergan patient surveys (patient surveys) and allergan patient information form (patient information form) to describe: 1. patient demographics 2. treatment patterns 3. patient feedback and overall experience with mms treatment


Eligibility criteria:
inclusion criteria * subject has received mms treatment in the abdomen and/or buttocks (with cooltone prototype) * subject has completed the allergan patient survey and information form on mms experience between july 1, 2019 and december 1, 2019. exclusion criteria • there are no exclusion criteria for this study.
vitamin a bioavailability in lactating women with marginal vitamin a status

Conditions: Vitamin A Deficiency

Summary: the study will assess the relative bioavailability and bioefficacy of cryptoxanthin (cx) and beta-carotene (bc) from food sources for increasing breast milk carotenoid and retinol concentrations in lactating bangladeshi women.

the specific aim is to compare the effects of orange-fleshed sweet potatoes and tangerines compared to white-fleshed sweet potatoes and vitamin a as retinyl palmitate on blood and breast milk cryptoxanthin (cx), beta-carotene (bc), and vitamin a (va) concentrations by randomly assigning lactating bangladeshi women to one of four treatment groups for 6 days/week for 3 weeks. the investigators will also compare the relative vitamin a (va) value of bc and cx from food sources by comparing the mean change in breast milk retinol concentrations of the groups that receive tangerines (cx) or orange-fleshed sweet potatoes (bc) with the mean change in breast milk retinol of the group that receives retinyl palmitate.

Eligibility criteria:
inclusion criteria: * healthy women in dhaka, bangladesh * lactating women in their 2nd or 3rd month of lactation who are planning to breast-feed at least 6 months * breast-feeding only one infant * age range 18 to 45 years * not pregnant * serum retinol concentrations \>0.70 umol/l and \<1.10 umol/l * normal concentrations of crp (\<10 mg/l) * at least one arm vein deemed adequate for blood collection, as evaluated by a screening nurse. * willing to consume the test foods daily 6 d/wk for one month exclusion criteria: * health status is not compatible with the inclusion criteria, such as screening blood chemistries indicative of vitamin a deficiency. * severe anemia (hb \<9 mg/dl) * current pregnancy * must not have known allergy to citrus fruit (tangerines or mandarin oranges) or sweet potatoes * must have no obvious psychological or sociological problems-such as alcoholism, drug abuse, or severe and acute mental illness that would influence their ability to sign an inform consent agreement or to participate in study duties and activities

Keywords: lactation cryptoxanthin beta-carotene vitamin a
collecting and storing tissue and dna samples from patients undergoing a donor stem cell transplant

Conditions: Breast Cancer; Chronic Myeloproliferative Disorders; Gestational Trophoblastic Tumor; Graft Versus Host Disease; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms; Neuroblastoma; Ovarian Cancer; Testicular Germ Cell Tumor

Summary: rationale: collecting and storing samples of blood, urine, and tissue from patients undergoing a donor stem cell transplant to test in the laboratory may help the study of graft-versus-host disease in the future. purpose: this research study is collecting and storing tissue and dna samples from patients undergoing a donor stem cell transplant.

objectives: * to establish a dna bank from donor and recipient (prior to transplant) peripheral blood for snp studies. * to establish a tissue bank for gene expression studies using donor and recipient (post-transplant) peripheral blood samples. * to establish a tissue bank for proteomic studies using donor and recipient blood and urine samples. * to establish a tissue bank for various studies using biopsy specimens. * to establish a tissue bank for flow cytometric studies using recipient (post-transplant), and sample from stem cell product. outline: peripheral blood samples are collected from donors prior to stem cell mobilization and from patients prior to starting preparative regimen. samples are studied by single nucleotide polymorphism (snp) analysis, snp array, proteomic analysis, gene expression, and other immunological laboratory methods. blood, urine, and tissue samples are preserved for future studies. extra skin biopsies and gastrointestinal biopsies are performed at diagnosis of graft-vs-host disease and preserved in a tissue bank for flow cytometric studies.

Eligibility criteria:
disease characteristics: * approved for allogeneic stem cell transplantation * sample of the stem cells from donor must meet 1 of the following criteria: * total peripheral blood stem cell dose \> 5 x10\^6 cd34+ cells/kg * marrow cell dose \> 3 x 10\^8 nucleated cells/kg patient characteristics: * platelet count \> 50,000/mm³ (for patients undergoing endoscopic biopsies) * inr \< 1.5 (for patients undergoing endoscopic biopsies) prior concurrent therapy: * see disease characteristics
mechanisms of increased disease severity in ad patients with the il-4ra r576 polymorphism

Conditions: Atopic Dermatitis

Summary: this protocol is primarily looking to see if the il-4ra r576 polymorphism is associated with increased clinical, immunological and microbial markers of disease activity in patients with atopic dermatitis.

for this study, participants ages 6-65 years, who have atopic dermatitis and don't have any of the exclusion criteria will be invited to participate in the study. there will be a 1 time visit where questionnaires, blood draw, skin swab and skin biopsies will be performed.

Eligibility criteria:
inclusion criteria: 1. male or female participants ≥6 to 65 yrs of age 2. meet ad standard diagnostic criteria exclusion criteria: 1. enrollment in another clinical trial 2. hypersensitivity to an agent used for the skin decolonization protocol 3. use within 4 weeks of systemic treatment with immunosuppressive/immunomodulating drugs (corticosteroids, cyclosporine, mycophenolate, jak inhibitors, azathioprine, methotrexate) 4. phototherapy for ad within 4 weeks 5. treatment with biologics (dupilumab, omalizumab, benralizumab, etc) within sixteen weeks 6. use of topical steroids, topical calcineurin inhibitors or crisaborale within 7 days 7. bleach baths within 7 days of the first visit 8. use of oral or topical antibiotics within 21 days of the beginning of the study 9. asthmatics receiving more than 500 μg per day of inhaled corticosteroids 10. history of (hiv, hepatitis b, hepatitis c, tuberculosis malignancy 11. skin comorbidities that may interfere with assessments: psoriasis, cutaneous t cell lymphoma,, 12. severe ongoing medical illnesses e.g. cardiovascular, renal disease, autoimmune disease. 13. febrile illness at time of visits 14. suspected immune deficiency or family history of primary immunodeficiency
validating an elispot for early detection of an active immune response against covid-19

Conditions: Covid 19

Summary: the rt-pcr on rhino-pharynge sampling highlights the genetic material of the virus and indicates that a subject is infected with sars-cov-2. this test can be in about 30% of false negative cases, it does not allow to date the infection, nor to predict the asymptomatic, mild, moderate or severe evolution of the disease. in terms of public health, we need 1/ to better understand the chronology of the immune response to the virus in the general population and in contacts of index cases; 2/ to know which characteristics of the immune response are protective of future reinfections. finally, in symptomatic subjects, we need biomarkers that predict the evolutionary mode of the disease (moderate vs. severe form).


Eligibility criteria:
inclusion criteria: * age ≥ 18 years, * patients with confirmed sars-cov2 infection (rt pcr positive) * or patients suspected (evocative chest scanner) * or patients exposure to sars-cov2 but no symptoms (patient's family, caregivers) * or patients non exposure to sars-cov2 volunteer subjects (general population) exclusion criteria: * pregnant or breastfeeding female
safety, efficacy of bnt162b2 mrna vaccine in cll

Conditions: Chronic Lymphocytic Leukemia

Summary: on behalf of the israel cll study group the investigators will evaluate the efficacy and safety of bnt162b2 mrna covid-19 vaccine in patients with chronic lymphocytic leukemia


Eligibility criteria:
inclusion criteria: * diagnosis of cll was according to the iwcll criteria * all patients received two 30-μg doses of bnt162b2, administered intramuscularly 3 weeks apart. (pfizer). exclusion criteria: * previous covid19 virus infection

Keywords: cll bnt162b2 mrna covid-19 vaccine
research project: pilot study on oral urea use in patients at high risk of kidney stone recurrence

Conditions: Kidney Stone

Summary: in clinical practice, many patients are not able to modify their habits to achieve a high level of diuresis and fluid intake and therefore are at an elevated risk for stone recurrence. the investigators think that ure-na (osmotic agent) taking could help to increase urine volume and decrease urine concentration, which would be of benefit in the prevention of kidney stones.


Eligibility criteria:
inclusion criteria: * 18 to 60 years of age * high risk for recurrence (1 or more of) bilateral or complex stones, recurrent stones, family history (1st degree relative), non-calcium stones, solitary kidney or anatomical abnormality, nephrocalcinosis, systemic disease with risk of stones (tubular acidosis, cystinuria, etc.) * diuresis \< 1.8 l/24 hours despite recommendations from physicians and/or nutritionist at the kidney stone clinic (as documented in the previous 6 months) exclusion criteria: * patient does not meet 1 of the 3 inclusion criteria * pregnancy or breastfeeding * lack of understanding about the protocol and effects of ure-na * expected inability to adequately increase fluid intake on ure-na