Kornimate/medical-research-clean huggingface dataset:
atypical antipsychotic-induced mitochondrial dysfunction in patients with schizophrenia

Conditions: Schizophrenia

Summary: schizophrenia is a serious mental disorder with a global prevalence of 1%. the main cause of this condition is dysfunction in the signaling of neurotransmitters dopamine, serotonin, glutamate and gamma-aminobutyric acid .according to recent research, a disturbed cellular energy state caused by mitochondrial dysfunction is thought to be a factor in the development of schizophrenia. the aim of the treatment of schizophrenia is to reduce symptoms and is mainly based on the monoamine hypothesis. atypical antipsychotics are the first-line of treatment. certain typical and atypical antipsychotic medications have been shown in prior preclinical research to decrease mitochondrial respiratory chain complex i activity. in contrast to individuals who were drug-naive, casademont et al. found a significant decrease in complex i activity with haloperidol and risperidone in one cross-sectional observational study. also, there is evidence suggesting that mitochondrial dysfunction is linked to the extrapyramidal side effects seen with antipsychotics. to date, there are no randomized controlled trials that assess the effect of these drugs on mitochondrial functions. hence, the present randomized controlled trial has been planned to evaluate and compare the clinical and biochemical markers of mitochondrial dysfunction in schizophrenia patients treated with the atypical antipsychotics risperidone and aripiprazole.


Eligibility criteria:
inclusion criteria: * patients meeting the dsm-5 criteria for diagnosis of schizophrenia. * treatment naıv̈ e patients or patients who had not taken any antipsychotic drugs for at least 4 weeks before recruitment. * patients of either sex between the ages of 18 and 60 years. * legally authorized representative (lar) of patients consenting to participate in the study by signing the informed consent form. exclusion criteria: * patients diagnosed with other psychiatric disorders including schizoaffective disorder or schizophrenia with somatoform disorders. * highly agitated patients who need immediate indoor-based treatment. * patients with known mitochondrial disorders (melas, lhon, leigh syndrome, kearnssayre syndrome, merrf etc.) * patients with history of comorbidities like cardiovascular, renal, hepatic, neurological, respiratory or endocrinal diseases or malignancies. * patients with history of substance abuse. * pregnant or lactating mothers.

Keywords: schizophrenia mitochondrial electron transport chain complex aripiprazole risperidone mitochondrial dysfunction
loco-regional analgesia for post-operative pain management in cardiac surgery

Conditions: Pain, Postoperative

Summary: the aim of the study is to evaluate whether loco-regional analgesia reduces post operative pain compared to intravenous analgesia, in patients undergoing cardiac surgery in minithoracotomy. all patients will be randomized to receive locoregional analgesia (treatment group) or intravenous analgesia (control group), at the end of the cardiac intervention.


Eligibility criteria:
inclusion criteria: * patients undergoing minithoracotomy for cardiac surgery, \> 18 years old exclusion criteria: * psychiatric diseases, which might limit pain evaluation; urgent surgery; patients on ecmo; lack of consent

Keywords: post-operative pain loco-regional analgesia minimally invasive surgery
denver garden environment and microbiome study disease

Conditions: Diet Modification; Physical Activity; Weight Gain; Chronic Disease; Lifestyle, Sedentary; Health Behavior

Summary: an interdisciplinary team with extensive garden study experience conducted a pilot randomized controlled clinical trial to see whether gardening reduced risk factors for diseases like cancer and heart disease. the pilot trial will provide preliminary data on associations between human microbiome, diet, physical activity, and social interactions and the outcomes of weight status and key inflammatory biomarkers.

the pilot study will lead to development of a future, large randomized controlled clinical trial, by fulfilling the following aims: pilot aim 1: demonstrate feasibility of recruitment and ability to perform study procedures. pilot aim 2: demonstrate the ability to measure accurately chronic disease risk factors such as diet, physical activity, weight gain, microbiome characteristics and inflammatory biomarkers. pilot aim 3: provide preliminary results on the efficacy of gardens as a preventive intervention, and estimates for a detailed power analysis for the proposed subsequent larger trial. aim 3a: demonstrate that compared to non-gardeners, gardeners have 1) greater intake of fruits and vegetables; 2) better healthy eating index (hei); 3) lower diet inflammatory index (dii); 4) reduced sedentary time and increased moderate-to-vigorous physical activity (mvpa); and reduced age-associated weight gain. aim 3b: for gardeners and non-gardeners, sample garden soil, gut, skin, and oral microbiome at six time points from april through september to characterize and compare bacterial load, pathogenic taxa, taxonomic diversity, relative dominance, indicator taxa, and metabolomic results. aim 3c: demonstrate that gardening reduces inflammatory biomarkers linked to heart disease and cancer, including crp, il1b, il4, il6, il10, and tnfa, and that the effect of gardening is mediated by diet, weight gain, physical activity and characteristics of the microbiome.

Eligibility criteria:
inclusion criteria: * able to give informed consent in english or spanish * aged 18 or over * currently on the wait list for a new garden * not have gardened in the past 2 gardening seasons exclusion criteria: * is not able to complete the study requirements in spanish or english * aged 17 or younger * has gardened in the past 2 gardening seasons

Keywords: pilot randomized controlled trial community garden health behavior change physical activity diet obesity neighborhood microbiome inflammatory biomarkers
yogurt study in children 2-4 years old attending daycare

Conditions: Infections, Respiratory; Diarrhea

Summary: the purpose of this study is to determine the effectiveness of probiotics (popularly referred to as 'live active culture' or 'good bacteria') in preventing illnesses and consequent absences from school/daycare centers of children two to four years old that attend daycare at least 3 days per week. two yogurt drinks will be administered, one containing a specific strain of probiotic, bb-12. it is hypothesized that children receiving the bb-12 drink will experience fewer illnesses and absences from daycare. in this study, participants will be asked to: 1. give their child 4 oz. of the test yogurt each day for 90 days 2. keep a daily diary of their child's health 3. collect 3 stool samples from their child at the start, middle, and end of the study 4. speak with research personnel on a bi-weekly basis regarding their child's health 5. ensure that their child to consume any yogurts or probiotic-containing products for 110 days of the study


Eligibility criteria:
inclusion criteria: * child aged 2 to 4 years of age * child attends daycare at least 3 days per week exclusion criteria: * caregiver does not speak english or spanish * caregiver does not agree to have their child refrain from cultured dairy products (yogurt) for the 105-day duration of the study * caregiver does not agree to collect a stool sample from their child on day 0, 45, and 105 of the study * caregiver does not have a refrigerator to store the yogurt product at home * child is currently receiving breast milk * child has an allergy or hypersensitivity to milk proteins or other dairy food components such as lactose * child has an allergy or hypersensitivity to strawberry or red food coloring * child has a chronic disease * child has had an infection or been sick 7 days prior to starting study * child has had diarrhea or constipation 7 days prior to starting study * child has a special diet as prescribed by a medical professional * child has received antibiotics, antiseptics, antifungal, corticosteroids, anti-histamines, non steroidal anti-inflammatory drugs within 7 days prior to starting the study * child has a congenital anomaly or birth defect that requires medical care

Keywords: probiotics child, preschool child day care centers health immune system
effect of transcutaneous electrical acupoint stimulation on dysmenorrhea among autoimmune disease women

Conditions: Autoimmune Diseases

Summary: this study will be conducted to investigate transcutaneous electrical acupoint stimulation effect on pain and disease aggravation during menstruation among autoimmune disease women

the monthly ovarian cycle is characterized by tightly regulated hormones predictably fluctuating throughout the reproductive years. the menstrual cycle plays a role in the exacerbation of rheumatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus, with flares occurring prior to and during menses, respectively given these previous observations, sex hormones are hypothesized to influence the biologic properties of the immune system and skin. women with rheumatoid arthritis (ra) reported increased pain, fatigue, and disease activity right before their period. furthermore, those with systemic lupus erythematosus (sle) experienced similar symptom flares during menses. the transcutaneous electrical acupoint stimulation (teas) is a combination of transcutaneous electrical nerve stimulation (tens) and traditional chi- nese acupoints. . electroacupuncture blocks pain by activating a variety of bioactive chemicals through peripheral, spinal, and supraspinal mechanisms such as the prompt release of β-endorphin and met-enkephalin . corticotrophin-releasing factor and prostaglandin e2 are also involved in electroacupuncture analgesia. there are growing literature to support the relationship between the aggravation of autoimmune disease symptoms during menstruation time which maximizes the negative effect on the female's the daily activities at that time. there is lack of researches on the effect of teas on this point .teas has positive effect on pain during menstrual cycle . the result of this study will help to evaluate the efficacy of teas on pain and disease severity during menstruation in women with autoimmune diseases.

Eligibility criteria:
inclusion criteria: * all women will be diagnosed with rheumatoid arthritis(ra) or systemic lupus erythematosus (sle). * all women will suffer from severe pain during menstruation * age will range from 25-40 years old. * body mass index: 18.5- 30 kg/m² * all women participated in the study will have regular menstrual cycle exclusion criteria: * secondary dysmenorrhea * any other autoimmune diseases not mention in research * cardiac or respiratory diseases * vaginal infection * anemia diseases
an investigation with an intra-vaginal device for stress urinary incontinence

Conditions: Stress Urinary Incontinence

Summary: this is a prospective, randomized, controlled, two-armed multi-center pre-market trial. nighty-six (96) subjects will be recruited at sites in sweden. patients with diagnosed stress urinary incontinence (sui), will be considered as potential study participants. after written informed consent has been acquired, a medical and surgical history, a physical examination (including pelvic examination), and a confirmation of the diagnosis of sui will be performed, followed by a confirmation of the inclusion/exclusion criteria. the study subjects fulfilling all the eligibility criteria will thereafter be randomized 3:1 into either the tvs group or the standard of care (soc) group.


Eligibility criteria:
inclusion criteria: 1. signed informed consent form 2. over the age of 18 years 3. women diagnosed with stress urinary incontinence 4. normal voiding without residual urine ≤100ml 5. leakage of at least 10 grams per 24 hours (based on pad-weight test) 6. provoking test with leakage exclusion criteria: 1. history of dominated urgency's symptoms 2. any contraindication for the investigational device; such as hypersensitivity to silicon rubber 3. unexplained pelvic bleeding or vaginal discharge 4. is hysterectomized,has a history of incontinent surgery or surgery for prolapse correction. 5. the woman is currently using prolapse ring 6. women with prolapse reaching the hymus during coughing. 7. pregnant or suspicion of pregnancy 8. urinary tract or vaginal infection 9. history of not being able to use tampons 10. neurogenic bladder dysfunction 11. the patient is to start, or change an ongoing, pelvic floor training 12. if the patient does not have a well adjusted diuretica, or is to start, or change an ongoing, diuretic treatment 13. the patient is participating in another study on sui 14. any other condition that as judged by the investigator may make follow-up or investigations inappropriate 15. any patient that according to the declaration of helsinki is unsuitable for enrollment

Keywords: vaginal medical device female stress urinary incontinence
change in stroke volume index after diuresis for patients with decompensated heart failure

Conditions: Acute Decompensated Heart Failure

Summary: this is a prospective cohort study for 50 patients admitted to the cardiac care unit requiring clinically-indicated diuretic therapy for congestive heart failure. the purpose of this study is to assess the role of non-invasive cardiac output monitoring (nicom) with the starling fluid management system (baxter medical, deerfield, il) in determining volume status in patients with acute decompensated heart failure requiring intravenous diuretic therapy.


Eligibility criteria:
inclusion criteria: 1. diagnosis of congestive acute decompensated heart failure (preserved or reduced ejection fraction) requiring clinically indicated iv diuresis 2. admission to coronary/cardiac intensive care unit or cardiac step down unit 3. able to provide written informed consent 4. anticipated need for iv diuretics \> 24 hrs exclusion criteria: 1. prisoner, pregnancy or post-partum stage, or age \< 18 years 2. known allergy to sensory material or gel 3. end stage renal disease or need for crrt 4. inability or contraindication to do a passive leg raise with both extremities (i.e., balloon pump, impella, spinal injury, amputation) 5. other situation that might increase subject risk, interfere with study procedures, or confound study findings based on the opinion of the clinician/investigator 6. inability to provide informed consent
amg 193 alone or in combination with other therapies in subjects with advanced thoracic tumors with homozygous mtap-deletion (master protocol) (mtapestry 104).

Conditions: Thoracic Tumors; Non-small Cell Lung Cancer

Summary: the study aims to determine maximum tolerated dose (mtd) or recommended combination dose of the mta-cooperative prmt5 inhibitor amg 193 administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (mtap)-deleted thoracic tumors. the study also aims to determine the safety profile of amg 193 administered in combination with other therapies in adult participants with metastatic or locally advanced mtap-deleted thoracic tumors.


Eligibility criteria:
inclusion criteria subprotocol a, b, and c * age ≥ 18 years (or ≥ legal age within the country if it is older than 18 years). * tumor tissue (formalin-fixed, paraffin-embedded sample) or an archival block must be available. participants without archived tumor tissue available may be allowed to enroll by undergoing tumor biopsy before amg 193 dosing. * homozygous mtap-deletion * able to swallow and retain po administered study treatment. * disease measurable as defined by recist v1.1. subprotocol a - histologically or cytologically confirmed diagnosis of nsclc. arm a (amg 193 + carboplatin + paclitaxel + pembrolizumab): - predominantly squamous histology. arm b (amg 193 + carboplatin + pemetrexed + pembrolizumab): - predominantly non-squamous histology. arm c (amg 193 + pembrolizumab): - pd-l1 positive. subprotocol b - histologically confirmed nsclc with homozygous mtap-deletion and kras p.g12c mutation. subprotocol c * histologically or cytologically confirmed diagnosis of nsclc with brain metastases. * brain lesion meeting rano-bm criteria for measurable disease. exclusion criteria subprotocol a, b, and c * cardiovascular and pulmonary exclusion criteria as defined in the protocol. * gastrointestinal tract disease causing the inability to take po medication, malabsorption syndrome, requirement for iv alimentation, gastric/jejunal tube feeds, uncontrolled inflammatory gastrointestinal disease (eg, crohn's disease, ulcerative colitis). * history of solid organ transplant. * major surgery within 28 days of first dose of amg 193. * prior treatment with a mat2a inhibitor or a prmt5 inhibitor. * radiation therapy within 28 days of first dose. subprotocol a - autoimmune disease or immunodeficiency disease as defined in the protocol'

Keywords: oncology methylthioadenosine phosphorylase amg 193 prmt5 inhibitor mtap nsclc
intranasal dexmedetomidine sedation at dose of 2 mcg/kg versus 4 mcg/kg in children undergoing mri

Conditions: Anesthesia; Deep Sedation; Magnetic Resonance Imaging; Pediatric ALL

Summary: this study aimed to compare the effectiveness of intranasal dexmedetomidine sedation at dose of 2 mcg/kg and 4 mcg/kg in children undergoing mri at cipto mangunkusumo hospital

ninety-four pediatric subjects who would undergo mri with sedation were recruited. subjects aged between 1-10 years old, asa i-ii, weighed between 1-30 kg were included in this study and assigned into two groups randomly. one group received 2 mcg/kg (ind2 group) and the other group received 4 mcg/kg (ind 4 group) of intranasal dexmedetomidine. randomization was done by the third party, who was not participated in the data collection, by using randomization tool from www.randomizer.org. dose of intranasal dexmedetomidine for each participant was concealed using closed envelope and was opened preprocedure by the second party who prepared the sedation drugs. the doctor, who gave sedation drug to the patient and recorded the data, was also blinded. all patients were blinded to data collection. patients were allowed to drink clear fluid until 2 hours and required to fast for 6 hours before the procedure. baseline heart rate, spo2 was recorded premedication. subjects in ind 2 and ind 4 group received 2 mcg/kg and 4 mcg/kg intranasal dexmedetomidine. intranasal drugs were given 45 minutes before the mri procedure through both nostrils using a 1 ml syringe. patient was maintained in supine position for 1-2 minutes to maximize absorption. after the patient was sedated, peripheral intravenous access was performed. the level of sedation was assessed using rss. heart rate, oxygen saturation, and rss are recorded every 10 minutes until the procedure was done. after the target sedation has been reached, mri started immediately. if the sedation target was not reached and/or the child moved, 0.5 mg/kg rescue dose of propofol would be given. after completing the mri procedure, the patient was then transferred to the recovery room to record the recovery time. outpatients were allowed to go home when they reached aldrete score of 9-10.

Eligibility criteria:
inclusion criteria: * subjects aged between 1-10 years old undergoing mri * asa i-ii * weighed between 1-30 kg exclusion criteria: * patients who had history of hypersensitivity reaction to dexmedetomidine or showed an allergic reaction due to sedation drugs during mri examination. * patients with cardiorespiratory, liver, kidney problems, risk of difficult airway, undergoing digoxin or beta blocker therapy, and failed to be sedated after 45 minutes since drug administered.
functional review of distal biceps re-insertion

Conditions: Distal Biceps Ruptures

Summary: this study seeks to test the hypothesis that endobutton repair of the ruptured distal biceps successfully restores elbow function.


Eligibility criteria:
inclusion criteria: * primary distal biceps repair with endobutton * at least two years from date of surgery exclusion criteria: * any ipsilateral wrist, forearm, or elbow condition * any contraindication to having an mri
orthostatic hypotension in elderly nursing home residents

Conditions: Orthostatic Hypotension

Summary: in this study the investigators aimed 1. to investigate the prevalence of orthostatic hypotension in elderly nursing home residents. 2. to investigate whether the presence of orthostatic hypotension influences the chance of successful rehabilitation.


Eligibility criteria:
inclusion criteria: * nursing home resident exclusion criteria: * patients at the palliative department * life expectancy \< 4 weeks * patients only temporarily admitted to the nursing home
effects of transverse thoracic mobilization with and without lower trapezius strengthening exercises

Conditions: Mechanical Neck Pain

Summary: mechanical neck pain is a common musculoskeletal problem, worldwide. patients with neck pain often have subjective complaints of muscle stiffness, tension, or tightness in addition to their pain located between the occiput and the third thoracic vertebra approximately 68% of the total population has experienced neck pain at least once in their lifetime, and it easily transforms into a chronic state (that persists for more than 3 months). in today's society, this is conspicuous in many laborers due to the increased use of computers, where the neck and shoulders are maintained in static abnormal postures to look at the computer screens and become vulnerable to cause neck pain. the aim of the study is to determine the comparative effects of transverse thoracic mobilization with and without lower trapezius strengthening exercises on pain, disability and range of motion in patients with mechanical neck pain.

a randomized controlled trial will be conducted in physiotherapy outpatient department of syed medical complex and islam hospital, sialkot. non-probability consecutive sampling will be used to collect the data. sample size of 20 subjects with age group between 18 to 40 years will be taken. data will be collected by using tools numeric pain rate scale (nprs) for pain, neck disability index (ndi) for disability and universal goniometer (ug) for range of motion of neck. an informed consent will be taken. a total of 20 subjects will be selected by following inclusion and exclusion criteria and will equally divided in to two groups by random number generator table. both groups will come thrice per week for a total of 4 weeks. the data will be analyzed using spss software version 25. after assessing normality of data by shapiro-wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups

Eligibility criteria:
inclusion criteria: * males and females between the age range of 18-40 years with mechanical neck pain for at least 3months. * examination- symptoms provoked by neck movement and/or palpation of neck musculature. * trapezius strength test -to assess lower trapezius muscle strength, patient in prone with shoulder 120 degree abducted and resist the shoulder extension diagonally. exclusion criteria: * osteoporosis * tumors * vertebral fractures * diagnosed psychological disorders * neck pain associated with vertigo * history of cervical and thoracic spine injury * cervical radiculopathy * traumatic neck injury * shoulder surgery

Keywords: neck pain trapezius muscle muscle strength range of motion