Kornimate/medical-research-clean huggingface dataset:
epi off versus epi on corneal collagen cross-linking in keratoconus patients

Conditions: Keratoconus

Summary: to evaluate two different techniques of cross linking: standard epithelium off (cxl epi off) versus trans-epithelial (cxl epi on) cross linking in patient with progressive keratoconus.

the aim of the study is to evaluate two different techniques of cross linking: standard epithelium off (cxl epi off) versus trans-epithelial (cxl epi on) cross linking in patient with progressive keratoconus. forty eyes from 32 patients with progressive keratoconus were prospectively enrolled from june 2014 to june 2015 in this non-blinded, randomized comparative study. twenty eyes were treated by cxl epi off and 20 by clx epi on, randomly assigned and followed for 2 years. all patients underwent a complete ophthalmologic testing that included uncorrected and best corrected visual acuity, central and peripheral corneal thickness, corneal astigmatism, simulated maximum, minimum, and average keratometry, corneal confocal microscopy, schirmer i and break-up time (but) tests, and the ocular surface disease index. intra-and postoperative complications were recorded. the solution used for cxl epi off comprised riboflavin 0.1% and dextran 20.0% (ricrolin), whereas the solution for cxl epi on (ricrolin, te) comprised riboflavin 0.1%, dextran 15.0%, trometamol (tris), and ethylene-diamine-tetra-acetic acid. ultraviolet-a treatment was performed with uv-x system at 3 mw/cm2.

Eligibility criteria:
inclusion criteria: * patients with evolving keratoconus * aged between 18 and 40 years * no evidence of corneal scarring exclusion criteria: * patients with central and paracentral corneal opacities * vogt's striae * previous intraocular surgery * history of herpetic keratitis * history of severe dry eye * concomitant autoimmune diseases.

Keywords: cross-linking
targeted intervention for melanoma prevention

Conditions: Melanoma

Summary: in this study, the researchers will conduct interviews with melanoma patients to describe the sun exposure and sun protection practices of patients and their children. the researchers will use the findings of this interview study to develop a salient intervention targeted to the needs of melanoma patients and their children. the researchers will evaluate the intervention in a randomized, controlled trial. the specific aims of this study are: * to interview 210 melanoma patients with children 12 years of age or younger to describe patients' socio-cognitive and psychological factors, describe patients' and children's sun exposure and sun protection practices, and identify determinants of patients' and children's sun exposure and protective practices. * to develop a targeted behavioral intervention that is designed to increase patients' protective practices to reduce their children's sun exposure, increase patients' self-protective practices, decrease the sun exposure levels of patients and their children, and positively influence socio-cognitive and psychological determinants of child-centered and self-protective practices. * to conduct a randomized, controlled trial in a sample of 360 melanoma patients with children 12 years of age or younger to evaluate the targeted behavioral intervention consisting of print and video materials. the intervention will be assessed for its effects on: 1) child sun exposure and sun protection; 2) patients' protective practices to reduce their children's sun exposure; 3) patients' sun exposure and self-protective practices; and 4) patients' socio-cognitive and psychological factors that facilitate behavior change.

research is to learn about awareness, attitudes, and behaviors related to sun exposure, sun protection, skin examination, and other risk-reducing behaviors. the results of this study will be used to design an educational program on sun protection for persons who have had melanoma and their children. the study will involve a telephone interview that will last about 45 minutes and will be scheduled at your convenience. your participation in this study is completely voluntary and you may refuse to participate. your decision about participating will not affect the care or services you or your family may receive at the university of texas m. d. anderson cancer center.

Eligibility criteria:
inclusion criteria: 1. melanoma patients are eligible if they were diagnosed with in situ, localized, or microscopic stage iii melanoma after january 1, 1988. 2. melanoma patients are eligible if they are the parent of a child 12 years of age or younger and reside with the child. 3. melanoma patients are eligible if they provide informed consent. 4. melanoma patients are eligible if they are 18 years of age or older. 5. melanoma patients are eligible if they are able to speak, read, and write english. 6. melanoma patients are eligible if they meet all inclusion criteria. exclusion criteria: 1) melanoma patients are not eligible if they cannot provide informed consent.

Keywords: melanoma sun exposure sun protection interview
cell free dna for the diagnosis and treatment in early nsclc

Conditions: Non-small Cell Lung Cancer

Summary: the aim of the study is to evaluate whether peripheral circulating cell-free tumor dna (cfdna) can aid screening of recurrence after complete resection of early stage non-small cell lung cancer.

during evolution of primary tumor, tumor cells can be released into the bloodstream. it has also been shown that circulating cell-free tumor dna (cfdna) is released from apoptotic or necrotic tumor cells. in a study of cfdna level after surgery in colon cancer patients, they suggested that cfdna could detect recurrence of cancer several months earlier than the conventional follow up studies. following several reports have suggested that cfdna can invade host cells and alter host cell biology to cause cancer metastasis. in this regard, we will collect from non-small cell lung cancer patients cohort who underwent curative resection, and will evaluate whether peripheral cfdna can aid early detection of cancer recurrence. we will also study the genomic signature of cfdna to assess the relationship between cfdna and clinical outcome of non-small cell lung cancer patients.

Eligibility criteria:
inclusion criteria: * all subjects need to sign the informed consent form * all subjects have non-small cell lung cancer which suspected on chest ct or confirmed pathologically preoperatively. * non-small cell lung cancer have to confirmed pathologically after operation * clinical stage i - iiia by ajcc 7th staging system exclusion criteria: * have been undergone chemotherapy or radiotherapy due to non-small call lung cancer * have been diagnosed any type of cancer other than cancer of skin, thyroid, uterine cervix with 3 years before enrollment * recurrent lung cancer * stage iiib, iv by ajcc 7th staging system

Keywords: non-small cell lung cancer recurrence cfdna
mpflr with fascia lata allograft, based on isometry assessment + elmslie-trillat tto

Conditions: Lateral Patellofemoral Dislocation Closed Traumatic; Lateral Patellar Luxation

Summary: the aim of this study is to assess outcomes of mpflr with fascia lata allograft, based on isometry assessment combined with elmslie-trillat tibial tuberosity osteotomy.

medial patellofemoral ligament (mpfl) injury occurs in more than 95% of lateral patellar dislocations. most of these injuries result in subsequent lateral patellar instability. therefore, mpfl reconstruction (mpflr) is often necessary. the aim of this study is to assess outcomes of mpflr with fascia lata allograft, based on isometry assessment combined with elmslie-trillat tibial tuberosity osteotomy. the primary outcome consists of the international knee documentation committee questionnaire (ikdc), the knee injury and osteoarthritis outcome score (koos) and retear rate.

Eligibility criteria:
inclusion criteria: * lateral patellar dislocation with subsequent instability * failure of non-operative treatment exclusion criteria: * active inflammation of the knee; * previous surgeries on the patellofemoral joint; * fractures around the knee
repetitive transcranial magnetic stimulation for the treatment of negative symptoms in schizophrenia patients.

Conditions: Schizophrenia

Summary: this study is to determine whether high frequency repetitive transcranial magnetic stimulation (rtms) is effective in the treatment of negative symptoms in schizophrenia patients

the principal objective of this trial is to investigate the effect of high frequency rtms on negative symptoms in schizophrenia.

Eligibility criteria:
inclusion criteria: * the diagnosis of schizophrenia according to dsm-iv； * 18～55 years old； * schizophrenic illness duration longer than one year; * the sum of negative scores in the range positive and negative symptom score (panss) must be 20 points or higher, at least one item from the area of negative symptoms (n1-n7) must be ≥ 4 points (at least moderate, clinically significant symptoms), and improvement in negative symptom-sum (measuring by panss) must be 10% or lower during the last two weeks before rtms stimulation. * have a stable and consistent drug treatment at least two weeks prior the rtms treatment; * able to adhere to the treatment schedule; * iq≥80; * dextromanual, normal vision and hearing; * signed an informed consent exclusion criteria: * rtms contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure; * acute risk of suicide and impulse； * patients to be diagnosed according to dsm-iv for substance abused, development delayed; * suffering from serious physical disease and can not accept the treatment; * history of epileptic seizures or the presence of epileptic activity documented on the basis of eeg; * difficult to maintain the current drug treatment for at least 1 month; * undergoing ect or mect in last 3 months; * current treatment with anticonvulsant acting drugs such as anticonvulsants, benzodiazepines.

Keywords: schizophrenia rtms
influence of a questionnaire on patients' emergency room expectations

Conditions: Emergencies; Satisfaction, Patient; Expectations; Physician-Patient Relations

Summary: the goal of this study is to determine whether a novel questionnaire designed to illicit patient's self-reported expectations across four domains (overall purpose of visit, medication intervention, imaging intervention and disposition) improves patient-provider communication as evaluated by an exit survey during an emergency room visit.


Eligibility criteria:
inclusion criteria: * patients who arrive through the ed main entrance (non-ems) * patients aged 18 years and older * patients who demonstrate decision making capacity * patients who willingly consent to participate exclusion criteria: * patients in distress (physical, emotional, or other) as determined by investigator * patients who demonstrate altered mental status or lack of capacity to consent * patients who require immediate medical intervention including diagnostic and/or treatment intervention * prisoners and patient under involuntary holds
dexmedetomidine improves recovery after cranial aneurysm surgery

Conditions: Aneurysm Cerebral

Summary: dexmedetomidine induces analgesic and sedative effects and is reported to decrease agitation during emergence after general anesthesia in various surgeries. for patients undergoing cranial aneurysm surgeries, a calm anesthesia and emergence is important. in this study, the investigatorstend to observe the effect of dexmedetomidine on maintenance and recovery of patients undergoing cranial aneurysm surgeries.


Eligibility criteria:
inclusion criteria: * patients undergoing cerebral aneurysm embolism under general anesthesia exclusion criteria: * patients with bradycardia or atrioventricular heart block * patients with asa(american society of anesthesiologists) status over 3 * patients with body mass index(bmi)≥30kg/m2 * patients with difficulty in communication * patients with ruptured aneurysm * patients suspected or proved to be pregnant

Keywords: dexmedetomidine general anesthesia cerebral aneurysm
comprehensive geriatric assessment in primary care: a randomised feasibility trial

Conditions: Frailty

Summary: the study aims to explore feasibility of implementing a tailored cga to older adults with frailty and evaluate staff and patients perception of the intervention. in line with this, the objectives of the study are: 1. to assess applicability of finding older adults with frailty using efi and delivering subsequent cga and care planning at patients' home 2. to investigate staff and older adults' perception of cga programme 3. to assess the health care resource usage and cost of the cga programme 4. to measure key health related outcome domains including function, quality of life, loneliness, pain, falls and mobility.


Eligibility criteria:
inclusion criteria: * age 65 to 95 years * efi score \> 0.12 exclusion criteria: * do not meet criteria for frailty based on gait speed, timed up and go test and prisma questionnaire

Keywords: comprehensive geriatric assessment frailty electronic frailty index efi care and support plan primary care
oasis study outcome assessment using sf-36 v2 in stroke patient study(oasis study)

Conditions: Stroke

Summary: 1. to survey the health-related quality of life using the sf-36v2 score of patients with chronic brain infarction in japan 2. chronic brain infarction in japan is better than eu/usa

period:2005-2007 observation time:baseline, 8week, 24week matters investigated: 1. qol determination using sf-36 v2 2. age, sex, brain infarction type, stroke severity (modified rankin scale), side of stroke, complication, smoking, alcohol, dizziness-vertigo-presyncope-light headedness, combination medicine, subjective symptoms, psychic symptoms, rehabilitation, recurrence, evaluation of depression (japan-stroke scale (jss)-d)

Eligibility criteria:
inclusion criteria: 1. patients whose last attack occurred more than 1 month ago 2. outpatients (including hospitalization for rehabilitation) 3. japanese nationality 4. patients who consented to participate in this study 5. group i: patients with dizziness, vertigo, presyncope, and light-headedness which are likely due to secondary chronic cerebral circulation impairment associated with sequelae of brain infarction, and patients for whom ketas (ibudilast) was prescribed group ii: patients without dizziness, vertigo, presyncope, and light-headedness which are likely due to chronic cerebral circulation impairment associated with sequelae of brain infarction exclusion criteria: 1. patients who cannot read, understand and fill in the questionnaire by themselves 2. patients who idle their time away 3. patients who are hospitalized 4. patients who are undergoing treatment for dizziness, vertigo, presyncope, light-headedness which are likely due to chronic cerebral circulation impairment associated with sequelae of brain infarction 5. patients whose dizziness, vertigo, presyncope, and light-headedness is definitely or likely caused by meniere disease, vestibular neuronitis, benign paroxysmal positional vertigo, otitis media, or epilepsy6. patients whom the investigator judges are not suitable to participate in the study

Keywords: brain infarction sf-36 hrqol japan post-stroke syndrome
the effects of using fertile chip in sperm selection for intracytoplasmic sperm injection in unexplained infertility

Conditions: Unexplained Infertility

Summary: the aim of the current study is to evaluate to effectiveness of sperm selection by using fertile chip in unexplained infertile couples on intracytoplasmic sperm injection (icsi) cycles.

the aim of the current study is to evaluate to effectiveness of sperm selection by using fertile chip in unexplained infertile couples on intracytoplasmic sperm injection (icsi) cycles. on study arm sperm selection will be performed by using special microchannel system which is called fertile chip (fc) without using sperm wash procedure. this fc system leads to select lineer motile progressive sperm selection. in control group, sperm selection will be performed by classical way which sperm will be undertaken to sperm wash by gradient method. after selection of sperm in both arms, icsi will be performed. the outcomes of icsi schedule will be assesed by fertilization and clinical pregnancy rates.

Eligibility criteria:
inclusion criteria: * between 20-37 year-old women * normal tubal patency, normal uterine cavity, normal ovulation, * between 20-40 year-old men * normal semen analyse by who criterias * unexplained infertile couples exclusion criteria: * poor ovarian reserve which is diagnosed by bologna criterias * abnormal semen analyse by who sperm criterias * abnormal ovulation problems,tubal patency or uterine cavity

Keywords: icsi sperm selection fertile chip ıcsı outcomes
clinical study of subretinal transplantation of human embryo stem cell derived retinal pigment epitheliums in treatment of macular degeneration diseases

Conditions: Macular Degeneration; Stargardt's Macular Dystrophy

Summary: the purpose of this study was to determine the safety and therapeutic effect of sub-retinal transplantation of human embryo stem cell derived retinal pigment epitheliums (hesc-rpe) in patients with macular degeneration diseases, and explore new treatment modalities for macular degeneration diseases (age-related macular degeneration and stargardt's macular dystrophy).


Eligibility criteria:
inclusion criteria: * aging from 18 to 75 years * must have signed informed consent * at least one visually impaired eye caused by macular degeneration diseases * can not be effectively treated with conventional therapies * best corrected visual acuity scores between 19 and 73 letter in etdrs (early treatment diabetic retinopathy ) eye chart , including 19 and 73 (or the equivalent of snellen eyesight from 20/400 to 20/40) * visual loss caused by macular degeneration diseases exclusion criteria: * eyes with concomitant diseases which will interfere the visual improvement of the study * active intraocular inflammation regardless of the grade of severity * active infection (e.g. conjunctivitis, keratitis, scleritis, uveitis, ophthalmia) * history of uveitis * severe cataract, glaucoma, retinal blood vessels occlusion, retinal detachment, macular hole, vitreous-macula traction * iris neovascularization * patients who have only one functioning eye, or the best corrected vision of untreated eye scores less than 24 letters in etdrs chart(corresponding to 20/320 in snellen chart) * history of intraocular surgery * severe systemic diseases: stroke, coronary heart disease, angina pectoris, renal insufficiency needing dialysis * allergic to sodium fluorescein * uncontrolled hypertension (systolic pressure\>140mmhg,or diastolic pressure\>90mmhg) * coagulative function disorder * system administration of drugs that are toxic to lens, retina, or optic nerve like hydroxychloroquine, phenothiazine, ethambutol, tamoxifen, etc. * involved in other clinical trials of any medicine within 1 month (or within 5 half-life periods) * have maternity plan in 6 months * in pregnancy or lactation period.

Keywords: human embryo stem cell derived retinal pigment epitheliums subretinal transplantation wet age related macular degeneration stargardt's macular dystrophy
influence of circadian clock on hormonal, metabolic, neurocognitive markers in adolescents with and without diabetes

Conditions: T1DM; Sleep Disorders, Circadian Rhythm; ADHD; Memory Impairment

Summary: type 1 diabetes mellitus (t1dm), makes its appearance during childhood and youth, but management implications last till late adulthood. its treatment includes the combination of multiple daily glucose measurements, insulin administration and balanced nutrition. the goals of therapy are to achieve glycemic control (hba1c \< 7.5%), and minimal glycemic excursions. furthermore, recent studies imply that keeping hba1c within target range is not sufficient to prevent complications, attributed mainly to blood glucose level fluctuating from high to low, associated with food intake and adolescents behavior. the current implication of glycemic control on the central nervous system (cns) includes abnormal electrical brain activity, structural changes in brain's white and grey matter, and cognitive impairment. still, little is known on the effect of sleep pattern, including circadian rhythm reversal ("biological clock) on asymptomatic glycemic excursions, and on cns functions. there is no data regarding the association of the biologic clock on cns functionality among adolescents, nonetheless among t1dm adolescents, for whom behavior and circadian rhythm alterations may have harmful effect. the investigators propose a cross-over designed study by examining adolescents with and without t1dm during 2 weeks of regular sleeping pattern (night sleep), and during 2 weeks of sleeping during the day as happens during summer vacation. the main objective of the proposed study is to offer proof of the clinical and metabolic relevance and cognitive effects of the reversal of the circadian clock in adolescents with and t1dm during summer vacations and weekends. study is designed to demonstrate a difference among healthy and diabetics during reversed night/day circadian clocks in the time spent within target range of glucose, performance on neuro cognitive tasks, electrical brain activity, and hormonal profile.


Eligibility criteria:
inclusion criteria: * families living in areas with high access to medical care. * age: 12-18 years old * t1d diagnosis for longer than 1 year * speaking fluent hebrew exclusion criteria: * significant renal or liver function abnormalities * head injuries, * epileptic episodes * psychiatric medications * lack of hebrew abilities * disagreement to comply with all the study requests * history of more than one episode of a severe hypoglycemic event in the past, including loss of consciousness or more than one episode of diabetic ketoacidosis.

Keywords: t1dm hypothalamus cortical brain glucose variability biological clock pediatrics
spasmodic dysphonia interviews

Conditions: Spasmodic Dysphonia; Quality of Life

Summary: previous research has shown that patients with voice disorders often have a lower quality of life and struggle with employment. spasmodic dysphonia (sd) is a voice disorder that causes abrupt and uncontrollable spasms of the voice box, often resulting in the person having lifelong changes in their voice and speech pattern. the current mainstay of treatment is injecting botulinum toxin (bt) injections into the vocal cord to ease the spasms. the same research team conducted a pilot study in april 2021 on patients with sd. the pilot study used questionnaires and short interviews to understand the livelihood of 10 sd patients. it displayed that sd may impact patients' quality of life. the investigators now aim to run an official research project, ethically approved, to explore the following questions further: 1. does sd impact the socio-economic lives of its patients? if so, how? 2. what role does bt play in the socio-economic livelihood of sd patients? to answer these questions, the investigators aim to interview 20 patients with spasmodic dysphonia.


Eligibility criteria:
inclusion criteria: * adults diagnosed with spasmodic dysphonia who have received at least one botulinum toxin injection. exclusion criteria: * below 18 years of age; additional laryngeal condition(s) severely affecting voice.

Keywords: qualitative study interviews quality of life spasmodic dysphonia botulinum toxin laryngology voice disorder