s9910, collecting and storing blood and bone marrow samples from patients with hematologic cancer

Conditions: Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms

Summary: rationale: collecting and storing samples of blood and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about diagnosing cancer and how well patients will respond to treatment. purpose: the purpose of this study is to collect and store blood and bone marrow samples from patients with hematologic cancer to be tested in the laboratory.

primary objective: * maintain and expand tissue repositories of highly characterized samples from patients with acute lymphoblastic leukemia, chronic lymphocytic leukemia, acute myeloid leukemia, chronic myelogenous leukemia, or myelodysplastic syndromes. other objectives as funding permits: * develop laboratory assays for rapid and precise diagnosis of leukemia using bone marrow and peripheral blood samples. * determine biologic, genetic, and molecular parameters that distinguish different subtypes of human leukemia with differing responses to therapy, and develop "risk-adapted" therapeutic approaches based on these parameters to tailor therapeutic regimens, randomize or stratify patients in clinical trials, or otherwise assist in therapeutic decision-making. * develop new automated and standardized laboratory methods for the detection and monitoring of therapeutic responsiveness and minimal residual disease in patients and use this information to design clinical trials. outline: patients receive treatment as directed by the southwest oncology group (swog) study to which they are registered. patients undergo collection of peripheral blood (myeloid leukemia) or venous blood (lymphoid leukemia) and bone marrow at baseline, at the time of response or remission, and at the time of progression or relapse. additional collections may take place according to the guidelines of the study in which the patient is registered. specimens are stored for use in laboratory research. projected accrual: samples from a maximum of 1,000 patients will be collected for this study.

Eligibility criteria:
disease characteristics: * currently registered on a southwest oncology group (swog) treatment study for acute lymphoblastic leukemia, chronic lymphocytic leukemia, acute myeloid leukemia, chronic myelogenous leukemia, or myelodysplastic syndromes patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: stage 0 chronic lymphocytic leukemia stage i chronic lymphocytic leukemia stage ii chronic lymphocytic leukemia stage iii chronic lymphocytic leukemia stage iv chronic lymphocytic leukemia recurrent adult acute myeloid leukemia recurrent adult acute lymphoblastic leukemia relapsing chronic myelogenous leukemia refractory chronic lymphocytic leukemia chronic phase chronic myelogenous leukemia accelerated phase chronic myelogenous leukemia blastic phase chronic myelogenous leukemia meningeal chronic myelogenous leukemia untreated adult acute lymphoblastic leukemia untreated adult acute myeloid leukemia adult acute myeloid leukemia with t(8;21)(q22;q22) adult acute myeloid leukemia with t(16;16)(p13;q22) adult acute myeloid leukemia with inv(16)(p13;q22) adult acute myeloid leukemia with 11q23 (mll) abnormalities adult acute myeloid leukemia with t(15;17)(q22;q12) adult acute lymphoblastic leukemia in remission childhood acute lymphoblastic leukemia in remission adult acute myeloid leukemia in remission childhood acute myeloid leukemia in remission recurrent childhood acute myeloid leukemia untreated childhood acute myeloid leukemia and other myeloid malignancies recurrent childhood acute lymphoblastic leukemia untreated childhood acute lymphoblastic leukemia childhood chronic myelogenous leukemia de novo myelodysplastic syndromes previously treated myelodysplastic syndromes secondary myelodysplastic syndromes secondary acute myeloid leukemia atypical chronic myeloid leukemia, bcr-abl1 negative chronic myelomonocytic leukemia juvenile myelomonocytic leukemia myelodysplastic/myeloproliferative neoplasm, unclassifiable childhood myelodysplastic syndromes