Kornimate/medical-research-clean huggingface dataset:
program for screening and prevention of eating disorders in obese young people in vulnerable neighborhoods of marseille: an action research

Conditions: Obesity

Summary: action research has been developed in this direction in order to use a tool to identify food disorder behavior among obese youths in their neighborhoods and social centers in vulnerable neighborhoods of marseille, with the aim of a multi-professional therapeutic management (psychosocial support, theater) and a specialized orientation. this program consists of the participation of each patient recruited in collective workshops. a total of 60 patients considered. our hypothesis lies in the fact that for young people to participate in an adapted device, taking into account the global needs of young people and their entourage, would limit the deleterious effects of obesity and promote the young person's autonomy and allow him to be a actor in the request for care. the project's objective is to provide support in the form of workshops with patients identified by the marseille hospitals public assistance health center as obese children and adolescents, in a precarious situation; to identify the presence of binge eating disorders and evaluate the impact of participation in these workshops on subsequent management by highly specialized professionals in food disorder behavior.

the mobile team (em) of the marseille hospitals public assistance health center has the mission to inform, screen, support and guide the access to care of people in targeted neighborhoods, said to be vulnerable, by the city's policy of marseille. the health space, a place of welcome and care, is located at a distance from any hospital structure within the most vulnerable neighborhoods of the city.

Eligibility criteria:
inclusion criteria : * boys or girls aged 11 to 17 * reside in the territory of intervention of the mobile team, i.e the 3rd, 14th, 15th and 16th arrondissement of marseille, districts said to be vulnerable by the city's policy. * body mass index greater than or equal to iotf-30 (has, 2011) * social precariousness score epices greater than or equal to 30riteria: * diagnosed eating disorder without medical and/or multi-professional care exclusion criteria: * child with major difficulty of behavior * patient with medical care
pilot study to measure lung biopsy diagnostic yield using always on electromagnetic tip tracked devices

Conditions: Pulmonary Coin Lesion

Summary: the objective of the prospective, multi-center study is to evaluate the ease of use and effectiveness of the spin drive electromagnetic (em) tip tracked steerable devices as a method of sampling subsegmental, less than 3.0 cm, lung lesions through the airway, and beyond the bronchus. measures of diagnostic yield will be compared to the diagnostic yield of similar published historical controls using conventional bronchoscopy.

always on em tip tracked steerable catheters and biopsy devices used with the veran medical technologies system are food and durg administration 510k approved for use in diagnostic pulmonary procedures to locate and sample subsegmental peripheral, less than 3.0 centimeter lung lesions or solitary pulmonary nodules(spn). up to 20 subjects with radiographically confirmed peripheral lung lesions will be asked to participate in the study and proceed with informed consent. an interim analysis of the data will be conducted to determine the need to include an additional 10 patients to achieve statistically significant results at the ninety five percent confidence interval.

Eligibility criteria:
inclusion criteria: * subject provides informed consent * subject is older than 50 years of age with 50% of patients at least 65 years of age * patient has a minimum of 20 pack years * subject scheduled to undergo conventional bronchoscopy as part of their standard medical care * subject has radiographically confirmed sub-segmental peripheral \< 3.0 cm lung lesions * a negative pregnancy test in women of child-bearing potential * subject is willing and able to return for all required follow-up * subject is mentally capable of following study directions exclusion criteria: * subject has pacemaker, implantable cardioverter, and/or defibrillator * subject has any disease or condition that interferes with safe completion of initial or follow-up assessments * pregnant or nursing female subjects, or female subjects of child bearing potential who refuse to take a pregnancy prior to their enrollment in this study * concurrent participation in another study involving investigational drugs or investigational medical devices * inability to read and understand the necessary study documents

Keywords: diagnostic yield electromagnetic tip tracked peripheral lung lesion
chalo! 2.0: a mobile technology based intervention to accelerate hiv testing and linkage to preventive treatment.

Conditions: Hiv

Summary: while hiv prevalence among msm in india is 10-15 times higher than in the general population (4.3% vs 0.3%), current interventions for indian msm have limited reach. in order to reduce the burden of hiv in msm, innovative, far-reaching prevention and treatment strategies are needed. guided by the increase access to internet-based social and mobile technologies (smt) (e.g. sms, whatsapp, dating apps) globally and in india, this is a 3-arm parallel, pragmatic randomized controlled trial of community-developed, theory based behavioral intervention (chalo! 2.0) delivered via whatsapp (secure sms application) compared to an attention-matched control, or a digital coupon for free hiv testing only control conditions. the primary outcomes are hiv-testing at 6 months (3 months after the end of the intervention) and linkage-to-preventive care (counseling or pre-exposure prophylaxis) at 12 months. the secondary outcomes are the frequency of hiv-testing by 18 months.


Eligibility criteria:
inclusion criteria: * live or work in mumbai or thane * fluent in hindi or english * have had anal sex with men in the past one year * report that they have either never been tested for hiv, are unaware of hiv test results, or are hiv-negative with last hiv test at any time, and have engaged in anal sex since last hiv test * able to provide and verify a whatsapp mobile number and email address * willing to answer online surveys for 18 months exclusion criteria: * participating in a concurrent hiv-related study * intention to move out of the mumbai metropolitan area in the next six months

Keywords: hiv screening hiv testing hiv prevention hiv linkage to care
investigation of correlation between concentrations of glucose in blood and interstitial fluid in type 1 diabetics

Conditions: Type 1 Diabetes

Summary: this is a mono-centre trial performed at the center for clinical research at the medical university graz. there will be a screening information and a study visit.in the study visit arterialized venous blood glucose values will be monitored and subcutaneous sampling of interstitial fluid (isf) with microdialysis for glucose determination will be performed. additionally to the laboratory analysis of the subcutaneous glucose samples, the glucose will be measured with extracorporeal on-line sensors and two marketed devices (guardian rt and glucoday s).the study visit will last 30 hours starting with the insertion of microdialysis catheters in the abdominal subcutaneous tissue and the insertion of the catheters for the glucoday s system and guardian rt system. the primary hypothesis of the study is: interstitial fluid glucose concentration profiles correlate to the arterialized venous blood glucose concentration profile in type 1 diabetic subjects.


Eligibility criteria:
inclusion criteria: * signed informed consent obtained before any trial-related activities. * skin fold thickness of minimally 5 mm * age of patients in the range from 19 to 60 years. * type 1 diabetes exclusion criteria: * severe acute and/or chronic diseases * mental incapacity, unwillingness or language barriers precluding adequate understanding or co-operation. * taking of any vasoactive substances or anticoagulation medication. * diseases of the skin which could interfere with application of the catheters * pregnancy or breastfeeding

Keywords: microdialysis subcutaneous adipose tissue glucose sensor glucose monitoring type 1 diabetes guardian rt glucoday s
antibiotic prophylaxis for simple hand lacerations

Conditions: Simple Hand Lacerations

Summary: research question: in emergency department patients with simple hand cuts, do prophylactic antibiotics reduce the risk of wound infections?

simple hand lacerations, defined as hand lacerations that do not involve special structures such as bones, tendons, vessels, or nerves, are common in the emergency departments. the exact rate of infection in such wounds is unclear. it is also not clear whether prescribing prophylactic antibiotics reduces the risk of infection in simple hand lacerations. the objective of this randomized double blind controlled study is to: 1. identify the rate of infection in simple hand lacerations, 2. identify factors or wound characteristics that increase the risk of infection, and 3. assess whether prescribing prophylactic antibiotics decreases the risk of infections in such wounds compared to placebo.

Eligibility criteria:
inclusion criteria: * all adult patients (≥ 18 years of age) presenting to the ed with simple hand lacerations. anatomically, lacerations distal to the radial carpal ligament will be considered "hand" lacerations. "simple" or "uncomplicated" laceration refers to one that does not involve any special tissue (bone, tendon, blood vessel, or nerve). exclusion criteria: * immunocompromised patients (cancer, chemotherapy, transplant, hiv/aids) * current or recent (within two weeks) use of any antibiotics * allergy to clindamycin or cephalexin * bites (e.g. dog, cat, or human) * lacerations resulted from crush injury * lacerations involving bone, tendon, blood vessel, or nerve * lacerations inflicted more than 12 hours prior to ed visit * pregnant or breast-feeding women

Keywords: wounds and lacerations hand infection antibiotics antibacterial agents
body awareness in dentistry students and working dentists

Conditions: Musculoskeletal Diseases; Body Image; Dentistry

Summary: the current study aims to comparison the body awareness and musculoskeletal problems of 1st dentistry students, intern students and working dentists and also investigate the factors affecting the body awareness over the years in dentistry profession.

dentists also have the highest prevalence among the occupational groups providing health services. more than 60% of dentists have pain in at least one of their body parts.pain due to musculoskeletal disorders can affect body awareness of person have chronic pain. body awareness is known as the capacity to distinguish body parts and has an important role in promoting well-coordinated movements. the current study aims to comparison the body awareness and musculoskeletal problems of 1st dentistry students, intern students and working dentists and also investigate the factors affecting the body awareness over the years in dentistry profession.

Eligibility criteria:
inclusion criteria: * the inclusion criteria are being between the ages of 18 and 65 and had been practising dentistry for more than two years for dentists group. exclusion criteria: * the exclusion criteria are had a surgical history of vertebral column or any neurological or inflammatory disorders or trauma history.
cdh - optimisation of neonatal ventilation

Conditions: Congenital Diaphragmatic Hernia

Summary: to determine the appropriate volume (size) of ventilator breath during volume-targetted ventilation for infants born with congenital diaphragmatic hernia.


Eligibility criteria:
inclusion criteria: * congenital diaphragmatic hernia - post-operative mechanically ventilated born at \>34/40 exclusion criteria: * neuromuscular blockade contraindications to ng/og tube insertion
ola to lowest dp in cardiac surgery

Conditions: Lung Collapse

Summary: this study aims to compared the effects in driving pressure of an open-lung strategy with a positive end-expiratory pressure (peep) titrated to best driving pressure (dp) after a rm versus the recommended protective peep of 5 cmh2o without a recruitment manuever in non-obese patients undergoing cardiac surgery.


Eligibility criteria:
inclusion criteria: * non-obese patients scheduled for cardiac surgery (cabg and valve replacement) exclusion criteria: * i) age \ 80yr, ii) pregnancy or breast-feeding status, and iii) patients with previous known respiratory disease, iv) body mass index \>35 kg/m2, v) emergency surgery and vi) hemodynamic instability at entry (need of vasopressors or ionotropes at entry or a ventricular assist device.
lymphedema treatment in head and neck cancer patients

Conditions: Head and Neck Cancer

Summary: the purpose of this research is to evaluate the result of treatment for neck lymphedema on throat pressure in patients who have received radiation therapy for head and neck cancer.

lymphedema is a failure of lymphatic system to transfer fluid from the connective tissue to the circulatory system. the lymphedema seen in patients treated for head and neck cancer can be seen externally on the neck and face, as well as internally in the lining of the throat. in this study, the investigators plan to treat the external lymphedema with a device called the flexitouch plus, which is already approved by the food and drug administration (fda) for lymphedema treatment, and to measure the degree of internal lymphedema using a pressure sensor to detect throat muscle pressure before and after the treatment with the flexitouch plus device.

Eligibility criteria:
inclusion criteria: * patients with tumors of the nasopharynx, oral cavity, oropharynx, hypopharynx, or larynx who will have radiation therapy as part of their treatment plan * both male and females * 18 to 100 years of age exclusion criteria: * significant surgical resection of pharyngeal constrictor muscles * patients with persistent or recurrent disease * patients who have contraindications to use flexitouch plus device

Keywords: head and neck cancer lymphedema treatment
study of high dose interleukin-2 (il-2) and stereotactic body radiation (sbrt) in patients with metastatic renal cancer

Conditions: Renal Cell Carcinoma

Summary: all patients will receive il-2 (14 planned doses with an additional cycle 14 days after the first). responding patients with regressing disease are eligible for up to 6 il-2 cycles. patients assigned to sbrt arm will receive two doses of sbrt on the wednesday and friday before the monday on which il-2 starts.

all patients will receive il-2 at 600,000 international units per kilogram (kg) by intraveneous bolus (ivb) every 8 hours for 14 planned doses with an additional cycle 14 days after the first. responding patients with regressing disease are eligible for up to 6 il-2 cycles. patients assigned to sbrt arm will receive two doses of sbrt at 20 gray (gy) on the wednesday and friday before the monday on which il-2 starts.

Eligibility criteria:
inclusion criteria: * histological confirmation of predominant conventional (clear cell) renal cancer * patients must be ≥ 18 years of age * tumors amenable to sbrt in lungs (central locations preferred), mediastinum, chest wall, bones with a soft tissue component (other than long bones), or liver, liver hilum and associated lymph nodes (inclusive of immediately adjacent masses), 1 - 3 foci; no minimum size, but none greater than 7 cm. patients may have other metastases but only a maximum of 3 will be treated * eastern cooperative oncology group (ecog) performance status of 0-1 * women of childbearing potential must have a negative serum or urine pregnancy test within 72 hours prior to the start of protocol treatment. in addition, women of childbearing potential as well as male patients must agree to take appropriate precautions to avoid pregnancy * patients must agree to participate in the prometheus il-2 patient registry (proclaim registry) * patients must sign a study-specific consent form exclusion criteria: * no metastatic site amenable to sbrt * patients with brain metastases not candidates for radiosurgery alone * previous radiation to sites proposed for sbrt * patients with active systemic, pulmonary, or pericardial infection * pregnant or lactating women, as treatment involves unforeseeable risks to the embryo or fetus * evidence of ischemia on exercise tolerance test, stress thallium study, or baseline ekg * clinically significant underlying pulmonary disease as measured by pulmonary function tests * blood tests within protocol-specified range * need for chronic steroids

Keywords: kidney cancer high dose il-2 sbrt
transcutaneous electrical vagus nerve stimulation to suppress atrial fibrillation

Conditions: Atrial Fibrillation; Inflammation

Summary: atrial fibrillation (af) is the most common cardiac arrhythmia. in previous experimental studies, the investigators found that low-level vagus nerve (vn) stimulation (llvns), at voltages substantially below that which slowed the sinus rate, significantly suppressed af inducibility and decreased af duration. the investigators subsequently developed a non-invasive neuromodulatory therapy, in which llvns was delivered to the auricular branch of the vn located at the tragus, the anterior protuberance of the outer canine ear (low level tragus stimulation; llts). the anti-arrhythmic effects of llts were similar to those of llvns delivered to the cervical vn trunk. more recently, in a proof-of-concept study in humans, the investigators showed that in patients with drug-refractory af undergoing af ablation, llts for just one hour significantly shortened the af duration and decreased inflammatory cytokines. the overall objective of this proposal is to translate in ambulatory patients with paroxysmal af the results of previous studies showing acute suppression of af and inflammation in anesthetized canines as well as humans, in order to examine the long-term therapeutic effects of this approach. the investigators hypothesize that intermittent (1 hour daily) llts for 6 months may result in long-term decrease of af burden and suppression inflammatory cytokines in patients with paroxysmal af. patients will be randomized to either active or sham llts. llts will be delivered through a transcutaneous electrical nerve stimulation (tens) device for 1 hour daily over a 6-month period. af burden will be defined as the percent of time spent in af over a 2-week period, assessed by noninvasive continuous ecg monitoring at baseline and at 6 months. in addition, blood samples will be collected from patients at baseline, and at 3 and 6 months, for cytokine measurement. these investigations will establish the first evidence of the long-term effects of llts on af suppression in patients with paroxysmal af and may provide the basis for a potential expansion of the therapeutic targets of this treatment modality beyond af.


Eligibility criteria:
inclusion criteria: 1. male and female patients older than 21 year old 2. paroxysmal af exclusion criteria: 1. left ventricular dysfunction (left ventricular ejection fraction \<40%) 2. significant valvular disorder (i.e., prosthetic valve or hemodynamically relevant valvular diseases) 3. recent (\<6 months) stroke or myocardial infarction 4. severe heart failure (nyha iv) 5. left atrial dilatation (\>55mm) 6. recurrent vaso-vagal syncopal episodes 7. unilateral or bilateral vagotomy 8. pregnancy or breast feeding 9. sick sinus syndrome, 2nd or 3rd degree av block, bifascicular block or prolonged (pr\>300ms) 1st degree av block.

Keywords: atrial fibrillation neuromodulation inflammation
clinical trial comparing outcomes of breast conserving operations with classic v high-frequency electrocoagulation

Conditions: Breast Cancer

Summary: the aim of this study is to assess the outcomes of breast conserving therapy operation depending on the type of surgical tool used: classic electrocoagulation with higher operative temperatures and high frequency electrocoagulation with lower operative temperatures. the investigators would assess the pain levels, length and amount of the lymphatic secretion as well as quality of life following breast conserving surgery.


Eligibility criteria:
inclusion criteria: * female * age 18-100 * breast cancer * stage iia and ii b (ct1a-3; cn0-1; cm0) * no previous breast surgery * no previous cancer * obtained informed consent exclusion criteria: * stages i, iii, iv * localised breast infection * previous breast surgery for any cause * previous cancer * no voluntary consent

Keywords: breast cancer stage 2 breast conserving therapy sentinel lymph node dissection high frequency electrocoagulation
padua prediction score in cirrhotic patients

Conditions: Portal Thrombosis

Summary: primary objective: to evaluate the predictive role of prediction score on the risk of developing venous thromboembolism in patients with liver cirrhosis admitted to non-surgical wards. secondary objectives: * to estimate the prevalence and incidence of venous thromboembolism in patients with liver cirrhosis admitted to non-surgical wards * to calculate the prevalence in the same subset of patients of major bleeding (defined as bleeding resulting in the patient's death, a drop in hemoglobin \> 2g/l, the need to transfuse \> 2 units of packed red blood cells or bleeding into a critical organ/space including the intracranial, retroperitoneal, intraocular, adrenal, spinal, pericardial districts) related to the application or not of thromboprophylaxis measures (pharmacological and mechanical) study design: the study is single center and it will be divided into two parts, a first retrospective part and a second prospective case control study. methods: adult patients with liver cirrhosis admitted in internal medicine and gastroenterology unit of policlinico agostino gemelli will be enrolled in the prospective study. for the retrospective part of the study, data about cirrhotic patients hospitalized in non-surgical departments of policlinico agostino gemelli will be collected. exclusion criteria will be hospitalization in surgical wards or intensive care units, patients with active bleeding at the time of admission, patients hospitalized for liver transplantation, anticoagulant therapy at therapeutic dosage at the time of admission for indications other than liver cirrhosis (e.g. personal history of thromboembolic events, atrial fibrillation/flutter or mechanical heart valves), contraindications to anticoagulant prophylaxis (recent or ongoing bleeding, creatinine clearance assessed by epi-ckd method \< 15 ml/min, platelet count \< 50 x 10\^9/l), patients hospitalized as elective regimen to perform invasive procedures that contraindicate anticoagulant prophylaxis (e.g. liver biopsy, local treatment of liver neoplasms, ligation of oesophageal varices), double antiplatelet therapy, pregnancy


Eligibility criteria:
inclusion criteria: * written informed consent * age more than 18 years old * diagnosis of liver cirrhosis * hospitalization in a medical department exclusion criteria: * pregnancy * ongoing double anticoagulation or double antiplatelet therapy at the moment of hospitalization * controindications to anticoagulation therapy * hospitalization in surgical environnment
research of resistance to antiplatelet agents and development of tailored treatment model for patients with coronary artery disease

Conditions: Cardiovascular Diseases; Coronary Artery Disease

Summary: the purpose of this study is to evaluate the prognosis of patients with resistance to antiplatelet agent and develop tailored treatment model for patients with coronary artery disease.


Eligibility criteria:
inclusion criteria: * age \>20 * patients with coronary artery disease * patients with peripheral artery disease exclusion criteria: * renal dysfunction * hepatic dysfunction * major surgery planned within 1 year * malignant tumor * history of gastrointestinal bleeding * low or high platelet count

Keywords: antiplatelet agents drug resistance