Kornimate/medical-research-clean huggingface dataset:
a randomized, prospective, multicenter study for the role of primary tumor resection in colorectal cancer patients with asymptomatic, synchronous unresectable metastasis

Conditions: Colorectal Cancer

Summary: short description for lay public, include brief statement of the study hypothesis


Eligibility criteria:
inclusion criteria: * age : between 20 and 90 years old * histologically confirmed adenocarcinoma of the colon or the upper rectum * patients with resectable primary colon or upper rectal cancer and unresectable metastatic lesions. * patients with no primary cancer related symptoms. * ecog performance status of 0 - 2 * appropriate organ functions (hepatic transaminases - less than 5 times the normal range; bilirubin - less than 2 times the normal range; creatinine serum - less than 1.5 times the normal range; thrombocyte - more than 100,000/µl; neutrophil - more than 1,500/µl) * asa score of \< 3 * an informed consent form has been signed by the patient. exclusion criteria: * the patient received adjuvant chemotherapy within the past 6 months. * the patient received chemotherapy for metastatic colon cancer. * the patient was planning to have curative surgery for the metastatic lesions. * the primary cancer is unresectable. * patients with peritoneal carcinomatosis. * patients with mid and low rectal cancer (\< 10cm) * patients with primary tumor related complications such as intestinal obstruction, intractable bleeding, and perforation, that needs to be treated. * asa score of \> 4 * the patient has chronic hepatitis or cirrhosis. an asymptomatic hbv or hcv carrier can participate. * patients with an active infection, which need antibiotic therapy, during the randomization period. * pregnant or breastfeeding women * patients who were enrolled in another clinical trial during the time of enrollment (within the 28 day randomization period). * patients with another different malignant tumor during the past 5 years. patients with treated non-melanoma skin cancer or cervical cancer can be enrolled in this study.

Keywords: colorectal cancer primary tumor resection chemotherapy overall survival quality of life
evaluation of ultra-portable ultrasound in general practice

Conditions: Pneumonia; Pleural Effusion; Renal Colic; Hepatic Colic or Cholecystitis; Subcutaneous Abscess or Cyst; Fracture of Long Bones; Intra-uterine Pregnancy or Extra-uterine Pregnancy or Miscarriage; Phlebitis

Summary: this is an interventional multi-centre study comparing two groups of general practitioners with or without an ultrasound scanner over a period of 6 months. the evaluation focuses on the management of patients for 8 pathologies: * pneumonia * pleural effusion * renal colic * hepatic colic or cholecystitis * subcutaneous abscess or cyst * fracture of long bones * intra-uterine pregnancy or extra-uterine pregnancy or miscarriage * phlebitis the principal hypothesis is that there are fewer complementary exams in the group of doctors using ultrasound scanners. the secondary hypotheses are: * there is better patient orientation (emergency care, specialist consultation, return home) in the group of doctors using the ultrasound scanners. * the global cost of the care is lower in the group of doctors using the ultrasound. * using ultrasound during the consultation decreases the anxiety of the patient. * using ultrasound increases the duration of the consultation. * there is no difference between the predicted and the real orientation of the patients.


Eligibility criteria:
inclusion criteria: * patients age 18 and over * consulting their general practitioner for one of the 8 conditions below exclusion criteria: * patients who have already received an imagery exam for the acute episode justifying the consult * opposition to participate

Keywords: ultrasound scanner sonogram general practice
psychosocial aspects of multiple endocrine neoplasia (men) syndromes

Conditions: Multiple Endocrine Neoplasia

Summary: the specific aims of the study include: 1. profile the demographic, health-related, psychosocial and behavioral characteristics of adults with men1 or men2. 2. evaluate men-specific distress as well as adherence to surveillance regimens among adults with men1 or men2, and identify associated with those outcomes.

the proposed cross-sectional study is intended to obtain information regarding current surveillance behaviors and other psychosocial outcomes among persons affected by the multiple endocrine neoplasia (men) 1 or men2, which are inherited conditions. study participants will include patients who have been seen previously at mdacc for evaluation of men1 or men2. because this is the first time investigators are contacting these patients to invite them to participate in psychosocial research, the proposed study also will help determine the feasibility of conducting similar studies in the future. investigators anticipate that data gathered from this study will enhance existing knowledge about the psychological and behavioral aspects of the men syndromes, and will inform future research efforts directed toward this understudied population.

Eligibility criteria:
inclusion criteria: 1. adults age 18 years or older, with a clinical or genetic diagnosis of men1 or men2 2. spouse, significant other, or family member who is at least 18 years of age and who is related to an individual who is a patient at mdacc and who has been diagnosed with men1. 3. ability to read and write english exclusion criteria: 1) inability to be contacted via mail (i.e., no contact information on record, incorrect address)

Keywords: multiple endocrine neoplasia questionnaire psychosocial surveillance behaviors men syndromes
covid-19 infection: exploration of respiratory control center abnormalities

Conditions: Covid19; Neurological Complication

Summary: the purpose of the present study is to determine whether there is a decrease in the emotional response to experimental induction of dyspnea by hypoxic stimulation in subjects with a "neurological" form of covid-19, compared to healthy controls.

sars cov-2 infection causes lung damage that can be severe enough to require artificial ventilation. clinicians taking care of these patients are surprised by the scant respiratory sensations and emotional responses described by patients. this attenuation of respiratory interoception deprives clinicians of the usual warning signs during respiratory decompensation of dyspnea and its aggravation. it may be the result of central nerve damage. this hypothesis is bolstered by the observation that within the multiple clinical forms of covid-19 infection there are some "neurological" forms (headache, anosmia, agueusia, dizziness, without respiratory signs and with little or no fever), that are most likely the consequence of olfactory penetration of the virus into the central nervous system (mechanism described for sars cov-1).

Eligibility criteria:
inclusion criteria: * - adult (≥ 18 years old, unprotected); * for covid-19 + patients: covid-19 + diagnosis; with quantitative or qualitative anomalies in taste and smell; first symptoms appeared in less than 21 days * for healthy subjects: have never presented any sign of covid ; confirmed by recent negative serology * understanding french; * affiliated to social security; * having a bmi between 20 and 30; * preferably non-smokers and in the event of recruitment difficulties, smokers but with smoking \<5 packs - year * signature of the informed consent form exclusion criteria: * respiratory signs or symptoms (rhinitis, cough, shortness of breath at rest); * temperature above 37.5 ° c; * existence of a chronic respiratory pathology (including asthma and copd in the first row); * pregnant women ; * protected minors and adults, persons deprived of their liberty; * not affiliated to a social security (including ame); * contraindication to mri (pace maker, intracranial implants, etc.).

Keywords: sars-cov-2 covid-19 dyspnea hypoxic stimulus
study of kb003 in biologics-inadequate rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to evaluate the safety, pharmacokinetics (pk), and efficacy of various repeat-dose regimens of kb003 in subjects with active rheumatoid arthritis (ra) who have had an inadequate prior treatment outcome from biologic therapy.


Eligibility criteria:
inclusion criteria: * at least 6 swollen and at least 6 tender joints * c-reactive protein (crp) \> upper limit normal (uln) * prior inadequate response from biologic therapy * stable regimens of concomitant ra therapies exclusion criteria: * unstable medical conditions

Keywords: rheumatoid arthritis biologics-inadequate kb003 gm-csf
yoga poses and breath control cardiovascular changes in hypertensive post-menopause women

Conditions: Hypertension; Postmenopausal Symptoms

Summary: autonomic and endothelial imbalance in post menopause women raise the need to manage cardiovascular risk. yoga poses and breathing control present controversial results on prevention and treatment of hypertension.. the aim of this study is to compare the effect of 12 week intervention based on yoga poses and their muscle contractions known as bandhas (pelvic floor, core and throat/neck) and ujjayi pranayama (victorious breath) on autonomic modulation, endothelial function, arterial stiffness, aerobic capacity and cognitive function of hypertensive post-menopausal women.

abstract: increased hypertension prevalence in post-menopausal women, along with cardiovascular damages such as autonomic and endothelial imbalance raise the need to include non-pharmacological interventions, such as yoga in the management of cardiovascular risk. yoga practices are composed by several variations of techniques including physical postures (yoga poses and specific muscles contractions), breathing control (pranayamas), relaxation and meditation, beside others.the effects of each of these compounds has not been elucidated up to date and can be considered confounding effects for commonly named "yoga programs". existing yoga based data are controversial about its effect on prevention and treatment of hypertension and point to poor methodological standards of most studies. considering the effects of comparable interventions such as slow breathing on improving autonomic modulation, resistive and isometric exercise on endothelial function, and associations of flexibility with arterial stiffness, it´s licit to search for specific effects of yoga compounds. thus, the aim of this study is to compare the effect of 12 week intervention based on yoga poses including their muscle contractions known as bandhas (pelvic floor, core and throat/neck), ujjayi pranayama (victorious breath) and stretching/ flexibility on autonomic modulation, endothelial function, arterial stiffness, aerobic capacity and cognitive function of hypertensive post-menopausal women.

Eligibility criteria:
inclusion criteria: * fsh\>35mui/ml * minimum 12 months amenorrhea * sedentary life style (less than 150 minutes per week of exercise) * never been in yoga -practicing (self declaration) * blood pressure \> 140/90 or in continuous use of medication (diuretics,ca+ channel inhibitors, ace inhibitors) exclusion criteria: * use of betablockers * recent cardiovascular events or surgery * renal alterations * respiratory and/or motor pathologies * smoking * bmi\>34,9

Keywords: yoga hypertension post-menopausal women heart rate variability
phase i/iia study of br1733 in subjects with advanced cancers

Conditions: Advanced Cancer; Follicular Lymphoma; Peripheral T Cell Lymphoma; Diffuse Large B Cell Lymphoma

Summary: this study is a phase i/iia, multi-center, open-label study of br1733 with a dose escalation part followed by a dose expansion part in adult subjects with advanced cancers. this treatment to characterize the safety, tolerability, pk, pd and preliminary antitumor activity. the study treatment will be administered until the subject experiences unacceptable toxicity, progressive disease, and/or has treatment discontinued at the discretion of the investigator or the subject, or due to withdrawal of consent.

this is a multi-center, nonrandomized, open-label study to evaluate the safety, tolerability, pharmacokinetics/ pharmacodynamics, and efficacy of br1733 in patients with advance cancer, such as recurrent/refractory follicular lymphoma, peripheral t cell lymphoma(ptcl), diffuse large b cell lymphoma(dlbcl) and advance solid tumors. phase ⅰ (dose escalation phase): according to the incidence of dlt in br1733 tablets in the treatment of advanced cancers, mtd and the phase 2 clinical trial dose (rp2d) combining pk, pd, efficacy and safety data were determined. phase iia (dose expansion stage): evaluate the efficacy and safety of br1733 monotherapy (cohorts 1-5) in five separate cohorts.

Eligibility criteria:
inclusion criteria: 1. sign informed consent voluntarily. 2. subjects with ptcl, dlbcl or advance solid tumors diagnosed by histology or cytology，whose disease progressed after standard treatment or have no standard treatment. 3. ecog≤2. 4. expected survival period ≥ 3 months. 5. adequate organ function reserve at baseline. exclusion criteria: 1. subjects with symptomatic central nervous system (cns) metastases or carcinomatous meningitis; 2. subjects with a history of other primary malignancies within 5 years (except for cured cervical carcinoma in situ, non-melanoma skin cancer, and superficial bladder tumor), subjects with other primary tumors who had no evidence of disease for 5 years or more and did not require treatment could participate in the study; 3. subjects with any severe uncontrolled disease such as liver disease such as cirrhosis, decompensated liver disease, kidney failure needs for hemodialysis or peritoneal dialysis, etc. 4. subjects with hiv disease or a positive hiv test; or active hepatitis. 5. subjects with organ transplantation (apart from keratoplasty) or allogeneic hematopoietic stem cell transplantation. 6. subjects with impaired or clinically significant cardiac cerebrovascular disease. 7. subjects known to be allergic to experimental drugs or similar compounds. 8. subjects known with psychotropic substance abuse, alcohol or drug abuse, or mental disorders. 9. any previous treatment with other eed inhibitors (e.g., mak683, ftx-6058, etc.). 10. females who are pregnant or breastfeeding.
the effect of web based progressive muscle relaxation exercise on clinical stress and anxiety of nursing students

Conditions: Anxiety; Stress; Nursing Students; Relaxation Program

Summary: purpose: the study was conducted to examine the effect of web-based progressive muscle relaxation exercise on the perceived stress and anxiety level of nursing students who were in clinical practice for the first time. method: this randomized controlled study was conducted at a state university in turkey. the sample of the study consisted of a total of 66 nursing students, 36 of whom were control and 30 interventions, who were educated in the 2021-2022 academic year, were in clinical practice for the first time and agreed to participate in the research. the intervention group was asked to perform a total of 36 sessions of progressive muscle relaxation exercise, 3 days a week for 12 weeks. data; it was collected using the "sociodemographic characteristics form", "state-trait anxiety inventory (dsq)" and "perceived stress inventory (psi)".


Eligibility criteria:
inclusion criteria: * being over 18 years old * studying in the 2021-2022 academic year * being in 2nd grade * not going into clinical practice before exclusion criteria: * being under the age of 18 * not studying in the 2021-2022 academic year * being in 1st, 3rd or 4th grade * prior clinical practice
radioscapholunate fusions after wrist trauma

Conditions: Posttraumatic Radiocarpal Osteoarthritis

Summary: the investigators conduced a clinical trial to evaluate the clinical and radiographic results after radioscapholunate fusion in case of posttraumatic radiocarpal osteoarthritis. because of poor clinical result, many authors upgrade the procedure including excision of the distal pole of the scaphoid and later excision of the entire triquetrum. only one study compared the three procedures in 17 patients. the investigators performed the same comparison in 85 patients with a mean follow up of 9,1 years (1-23)

the investigators compared three populations: patients with radioscapholunate (rsl) fusion alone, patients with rslfusion and distal scaphoid excision and patient with rsl fusion, distal scaphoid excision and excision of the triquetrum. the investigators performed clinical (pain, grasp strength, wrist motion), functional and radiographic (midcarpal osteoarthritis and radiocarpal nonunions) evaluation

Eligibility criteria:
inclusion criteria: * posttraumatic radiocarpal osteoarthritis * patients who underwent radioscapholunate fusion exclusion criteria: * patients with radiocarpal osteoarthritis due to rheumatoid or inflammatory disease and kienböck disease * patients with posttraumatic radiocarpal osteoarthritis managed with other surgery

Keywords: radioscapholunate fusion arthrodesis radiocarpal osteoarthritis partial radiocarpal fusion
comparative analysis of radiotherapeutic and medical procedures for the prophylaxis of heterotopic ossifications

Conditions: Heterotopic Ossification; Hip Arthropathy; Myositis Ossificans Traumatica, Thigh

Summary: aim of this study is to proof the efficacy of in jena established prophylaxis of new bone formation aside the skeleton with irradiation and compare it with the common literature. furthermore we want to compare irradiation treatment with the alternative prophylaxis with analgetics from the nsaid type.

aim of this retrospective analysis is to compare the incidence of heterotopic ossification one year after total hip arthroplasty with the at our location established concept of irradiation 24h preoperative and incidence in common literature. furthermore the comparison between irradiated patients and patients treated with nsaids.

Eligibility criteria:
inclusion criteria: patients with total hip arthroplasty performed at eisenberg patients with preoperative irradiation (24h pre-op) or postoperative diclofenac treatment patients with x-ray images immediately (3-5 days postoperative) postoperative and at least 365 days postoperative exclusion criteria: patients with missing follow up image

Keywords: heterotopic ossification total hip arthroplasty irradiation hip diclofenac prevention of ho nsaid brooker classification
prognosis in pregnant with covid-19

Conditions: COVID-19; Prognostic Factors; Pregnancy

Summary: covid-19 is a disease whose development, prognosis mechanism and immune status are still unknown. the aim of the study is to determine the relationship between clinical and laboratory data and the severity of the disease by evaluating the hematological and radiological features of the patients. the secondary aim is to determine the predictive values of clinical and laboratory data for the severity of covid-19.


Eligibility criteria:
inclusion criteria: * being pregnant with a diagnosis of covid-19 between the ages of 18-45 exclusion criteria: * suspected covid-19 diagnosis
investigation of the usability of neutrocheck amongst healthy volunteers and healthcare professionals.

Conditions: Neutropenia; Neutropenia, Febrile; Neutropenic Sepsis (Disorder)

Summary: this study proposes to assess the usability of the neutrocheck device and test kit amongst healthy volunteers and healthcare professionals (hcps). neutrocheck is a portable, single-use diagnostic test intended to aid the diagnosis of neutropenia, febrile neutropenia and neutropenic sepsis using a finger prick blood sample. neutropenia is when the number of infection-fighting neutrophil cells in the blood are lower than normal. it can be caused by treatments such as chemotherapy or by certain medical conditions. neutropenic sepsis is a life-threatening medical emergency that occurs when patients with neutropenia develop an infection. there is currently no way to test for neutropenic sepsis outside of hospitals. neutrocheck is being developed for use as a self-test by patients at home alongside remote consultation with a hcp or at point-of-care by a hcp. this will allow rapid identification of patients requiring urgent intravenous antibiotics and medical assessment. in cases where neutrocheck has eliminated the possibility of neutropenic sepsis, patients can avoid unnecessary and stressful hospital visits and valuable hospital resources will be saved. participants in this study will be invited to use the neutrocheck test kit in a setting similar to a home environment to carry out a test, whilst being observed by a study moderator. the neutrocheck devices used in the study will be for investigational use only. this study will not be testing the accuracy of the neutrocheck result, rather if neutrocheck can be used safely and in a user-friendly way. results will not be considered valid. planned study duration is 2 months. this approach will enable us to complete the current phase of development and advance to a clinical validation study of neutrocheck, assessing the diagnostic accuracy of neutrocheck amongst users including those at risk of neutropenia and neutropenic sepsis.


Eligibility criteria:
inclusion criteria: * provide informed consent to participate * age 18 years or over exclusion criteria: * known hiv or active hep b or hep c infection * phobia of needles or blood * currently undergoing immunosuppressive medical treatment or have received immunosuppressive treatment in the previous 3 months.
bioequivalency study of sertraline under fasting conditions

Conditions: Depression

Summary: the objective of this study was the bioequivalence of a roxane laboratories' sertraline tablets, 100 mg, to zoloft® tablets, 100 mg (pfizer) under fasting conditions using a single-dose, 2-treatment, 2-period, crossover design.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening. exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. * treatment with known enzyme altering drugs. * treatment with any triptan within 30 days prior to or during the study. * history of allergic or adverse response to sertraline or any comparable or similar product.
comparative analysis of outcomes among patients treated with xeljanz vs biologics

Conditions: Arthritis, Rheumatoid

Summary: to compare rheumatoid arthritis (ra) patient characteristics, adherence, and costs between patients treated with tofacitinib (ir, xr and combined groups) to patients treated with each of the bdmards.


Eligibility criteria:
inclusion criteria: * at least one claim for methotrexate during the variable-length pre-index period. * at least one claim for tofacitinib or bdmards between 01 february 2016 and 31 july 2019 (the identification period). exclusion criteria: * patients with claims for other conditions for which bdmards are used during the one-year pre-index period or on the index date: ankylosing spondylitis, crohn's disease, psoriasis, psoriatic arthritis, or ulcerative colitis will be excluded from the study. * patients with evidence of the index medication during the one-year pre-index period will be removed from the analysis. patients will be allowed to have been treated with (other) bdmards during the one-year pre-index period. * patients with more than 1 bdmard or bdmard with tofacitinib filled on the index date will be removed from the study.