Kornimate/medical-research-clean huggingface dataset:
caffeinated gum to prevent post-operative ileus: a prospective, randomized, placebo-controlled trial

Conditions: C.Surgical Procedure; Digestive System

Summary: this is a randomized, three-arm, double-blind, placebo-controlled, phase iii clinical trial of caffeinated gum and sugar-less gum in adult patients after an abdominal procedure. patients will be randomized to receive placebo, sugar-less gum or caffeinated gum three times daily for 30 minutes starting the day following surgery until discharge or 24 hours after attainment of the primary endpoint.


Eligibility criteria:
inclusion criteria: * abdominal procedure (laparoscopic or open, occurring electively), american society of anesthesiologists (asa) physical status score ≤ 3, glasgow coma score (gcs) ≥ 15. exclusion criteria: * asa physical status score of \>3, gcs \< 15, complete bowel obstruction, history of cardiac arrhythmia, history of phenylketonuria, alcohol abuse. substance abuse dentures
the effect of type 1 diabetes on pan-arterial vascular function and insulin sensitivity in humans

Conditions: Diabetes Type 1

Summary: arterial vascular disease is the major cause of morbidity and mortality for type 1 diabetic patients (dm1). metabolic insulin resistance (metir), even in the absence of hyperglycemia, conveys a 1.5 to 3-fold increased cvd risk in the general population. metabolic insulin resistance (metir) has been repeatedly shown to be prevalent in adults and adolescents with dm1. metir in obesity and dm2 are accompanied by vascular insulin resistance (vasir) which is characterized by impaired vasodilatory action of insulin on resistance or microvascular vessels. vasir has not been systematically studied in dm1. we hypothesize that in young adults dm1 impairs both baseline and insulin-responsive vascular function throughout the arterial vasculature.

in our study, 20 healthy control subjects will be compared to 20 dm1 patients (18-40 yrs). we will assess function in conduit (pulse wave velocity-pwv, flow-mediated dilation-fmd and augmentation index-ai), resistance (post-ischemic flow velocity-pifv) and heart and skeletal muscle microvascular (contrast enhanced ultrasound-ceu) vessels before and after 2 hrs of a euglycemic insulin clamp.

Eligibility criteria:
inclusion criteria: * age 18-40 * bmi ≤ 25 * healthy with no chronic illness (control group only) * normal screening labs or no clinically significant values * dm1 subjects will have been on insulin for at least 5 years and hba1c \<9 exclusion criteria: * first degree relative with type 1 or 2 diabetes (for control group only) * smoking presently or in the past 6 months * medications that affect the vasculature (except ace or arb in dm1 subjects, although they will need to be off these drugs for 2 weeks prior to study). * elevated ldl cholesterol \> 160 * bp \ 160/90 * pulse oximetry \<90% * pregnant or breastfeeding * history of cardiovascular disease, cerebral vascular disease, peripheral vascular disease, liver disease * presence of an intracardiac or intrapulmonary shunt (we will screen for this by auscultation during the physical exam ). * known hypersensitivity to perflutren (contained in definity) * for dm1 group: * hba1c ≥ 9 * microalbuminuria * retinipathy * ketoacidosis within the past year.

Keywords: diabetes type 1 vascular function
low-level laser therapy in distal radius fractures

Conditions: Colles' Fracture

Summary: conservative treatment of distal radius fracture is immobilisation with cast for 4-6 weeks. after removing the cast, it is common to still have pain, swelling and reduced mobility in the wrist. the aim of this study is to evaluate the influence of lllt on the hand.

patient with distal radius fractures are after removal of the cast are recruited form bergen emergency department, where the are randomly divided into two groups with concealed allocation. patient will be treated 3 times a week, for 3 week. after removal of the cast, the patients pain threshold, swelling, arom, strength and function is measured. the patients will meet for following-up controls until 26 weeks after injury. changes in outcome measures during the study: due to covid 19 virus restrictions, we had to abandon the objective physical measurements as planned. primary outcome measures were retrieved allowing no physical contact with the participants (ipad, telephone or e-mail).

Eligibility criteria:
inclusion criteria: * patients with distal radius fracture, with or without ulna fracture (colles' fracture * the breach must be closed * after reduction: 0 degrees dorsal displacement of radius * under 5 degrees shortening of the radius * under 3 mm step in the joint * 18+ years exclusion criteria: * people who do not speak norwegian or english * if the patient is pregnant * patient with smith fracture * wounds over fracture area * if the patient hav a peripheral neve injury * if the patient had (previously) operated the wrist * persons with verified osteoporosis at the time of injury, systemic inflammatory disease (rheumatism), mental illness, stroke, parkinson's disease, multiple sclerosis, cancer or congenital malformations in wrist * if the laser treatment can not be started within 3 days after removal of the cast

Keywords: distal radius fracture low level laser therapy
emergency psychological intervention with children: alex storm

Conditions: Psychological Trauma

Summary: alex storm hits france, especially the french riviera, from september 30, 2020 to october 3, 2020. a lot of people have been impacted by this event. among these people, 116 children have been taking care by the medico-psychological emergency unit and have been assessed by child psychiatrists or by psychologists.

alex storm hits france from september 30, 2020 to october 3, 2020. on october 2, several valley in the nice hinterland were devastated by this natural disaster. nine people died during this storm and hundreds of families were affected (house washed away or uninhabitable). this led to emergency evacuations on october 3 of several families. the inhabitants of some villages have been subjected to prolonged stress (lack of water and electricity, difficulty in supplying food, fear of another storm). these villages were isolated for a period varying from fifteen days to over three months. these people are particularly exposed to psychological consequences. between october 3 and october 30, the cump (medico-psychological emergency unit) was mobilized to provide psychological first aid to these families. among those seen in emergency 116 children were taken care of. in order to assess the immediate symptoms of the children, the investigators used an assessment sheet specific to the developmental ages of the children. all children seen in an emergency between october 3 and october 30, 2020 were assessed by child psychiatrists or by psychologists trained in emergency and pediatric psychological trauma.

Eligibility criteria:
inclusion criteria: * children impacted by the alex storm * children seen in an emergency between october 3 and october 30, 2020 * children were assessed by child psychiatrists or by psychologists trained in emergency and pediatric psychological trauma exclusion criteria: * children whose parents refused to the processing of their data
effect of oxygen breathing on flicker induced blood flow changes in the optic nerve head

Conditions: Healthy

Summary: background it has recently been shown that diffuse luminance flicker increases retinal and optic nerve head blood flow. this indicates that a neuro-vascular coupling between neural activity and blood flow exists as described previously for the brain. although a lot of mediators such as no, po2, pco2, h+ and k+ have been proposed, the mechanism of this coupling is still a matter of controversy. however, it has been shown in an animal experiment, that an increase in blood flow, evoked by diffuse luminance flicker stimulation is paralleled by an decrease in po2 in the tissue. thus, in this study we set out to investigate the flicker light induced increase in blood flow under elevated blood po2. study rationale the motive for the investigation of retinal blood flow regulation is to enhance our understanding of the coupling mechanism between increased neural activity and blood flow in the retina in order to gain new insight in the pathophysiology of several eye diseases associated with ocular vascular disorders study objectives to test the hypothesis whether oxygen breathing influences flicker light induced changes in optic nerve head blood flow


Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study * treatment in the previous 3 weeks with any drug * symptoms of a clinically relevant illness in the 3 weeks before the first study day * blood donation during the previous 3 weeks
oral status and prevalence of dental trauma in children treated with ritalin due to attention-deficit hyperactivity disorder (adhd)

Conditions: Attention Deficit Disorder With Hyperactivity; Dental Caries; Dental Occlusion, Traumatic

Summary: to evaluate the dental status of children using ritalin and suffering from adha in comparison to healthy children.

in this trial oral and dental status of 30 children (ages 5-12) who suffer from adhd and treated with ritalin will be evaluated. parameters that will be checked are the following: dmft - decay, missing, filling teeth for dental status, gi - gingival index, pi - plaque index for periodontal status. oj - over jet and ob - over bite for inter-maxillary relations and susceptibility for dental trauma. in addition these parameters will be collected for 30 age and sex match healthy children.

Eligibility criteria:
inclusion criteria: * children ages 5-12 years healthy children children taking ritalin who suffer from adhd exclusion criteria: * all others

Keywords: ritalin adha dental status periodontal status attention-deficit hyperactivity disorder dental trauma
study of pediatric migraine: the pediatric migraine registry

Conditions: Migraine

Summary: this is a multi-center registry that will prospectively collect regulatory compliant data from children and adolescents with migraine. this study will enroll approximately 200 participants from approximately 20 sites and will examine migraine symptoms, therapeutics used, and biomarkers associated with migraine.


Eligibility criteria:
inclusion criteria: * 4 to 17 years of age inclusive at the time of enrollment visit * meets international classification of headache disorders, 3rd edition criteria for migraine with or without aura * guardian provides informed consent/hipaa * participant provides assent if developmentally appropriate and required by the institutional review board exclusion criteria: * any condition which would make the participant, in the opinion of the investigator, unsuitable for the study
a phase 3 clinical study of shr-a1912 combined with r-gemox versus r-gemox in diffuse large b-cell lymphoma

Conditions: Diffuse Large B-cell Lymphoma

Summary: this is a multicenter, randomized, open-label, phase 3 clinical study to evaluate the efficacy of shr-a1912 combined with r-gemox in relapsed refractory diffuse large b-cell lymphoma.


Eligibility criteria:
inclusion criteria: 1. histologically confirmed diffuse large b-cell lymphoma (dlbcl). 2. have received ≥1 line of systemic antitumor therapy. 3. at least one bi-dimensionally measurable lesion. 4. expected survival of at least 3 months. 5. age ≥18 years old and under 80 years old. 6. the patients voluntarily participated in the study, signed informed consent, had good compliance and were willing to cooperate with follow-up. exclusion criteria: 1. central nervous system lymphoma involvement. 2. primary mediastinal (thymus) large b-cell lymphoma. 3. patients who have only one prior line therapy and are candidates for stem cell transplantation. 4. a history of immunodeficiency. 5. a history of severe cardiovascular disease. 6. a history of other malignancies within 5 years prior to administration of the first dose.
uppsala-dalarna dementia and gait project

Conditions: Dementia; Dementia, Mixed; Dementia Senile; Dementia of Alzheimer Type; Mild Cognitive Impairment; Subjective Cognitive Impairment

Summary: uddgait™ is a multidisciplinary research project with the overreaching goal of providing an aid for early identification of cognitive impairment and risk of dementia development, thereby providing a basis for adequate symptom relieving and health promoting interventions. a new concept is investigated for this purpose: a "dual-task-test", which implies the combination of a well-established mobility test (timed up-and-go, tug) with a simultaneous verbal task (i.e. tug dual-task, tugdt). this type of test has been judged as a potential aid for early identification of dementia disease. more research is needed to further examine the test's validity, reliability and predictive capacity. the overall aim is to investigate if tugdt is useful as an aid for prediction of dementia disease. to ensure the results, the aim is also to evaluate the test's measurement properties and to generate normative reference values of healthy control persons.


Eligibility criteria:
inclusion criteria: * patients undergoing memory assessment at at uppsala university hospital, sweden * patients undergoing memory assessment at at falu hospital, sweden * cognitively unimpaired individuals with a mini mental state examination (mmse) score of \> 26 exclusion criteria: * inability to walk three meters back and forth * inability to rise from a sitting position * indoor use of a walking aid * current or recent hospitalization (within the last 2 weeks) * need of an interpreter to communicate in swedish

Keywords: timed up-and-go, tug tug dual-task cognitive tests dementia mild cognitive impairment subjective cognitive impairment alzheimer's disease step parameters video recorded tests
the use of botulinum toxin in the management of myofascial pain syndrome

Conditions: Myofacial Pain Syndrome

Summary: the objective of this study was to assess the efficacy of botulinum toxin type (a) (bonta) injection in myofascial pain syndrome management in the terms of duration of function improvement and pain reduction. material and methods: fourteen patients with myofascial pain syndrome related to masticatory muscles were presented with trismus, pain and impairment of oral function. treatment plan was established by utilizing thirty units of botulinum toxin type (a) which was injected into masseter and sometimes temporalis muscle.

myofascial pain syndrome (mps) is acute or chronic musculoskeletal pain that characterized by the presence of unique trigger points of pain (trps) . etiology of this condition may include psychogenic stress, prolong muscle strain, trauma to the joint or muscle, arthritis, myositis, chronic infection, and general fatigue. current therapeutic approaches available for myofascial pain syndrome involved pharmacological and non-pharmacological treatment options. the non-pharmacological techniques may include a) manual therapy by muscle stretch or massage, b) muscular taut band injection by local anesthesia or botulinum toxin, c) acupuncture, and d) therapeutic ultrasound . botulinum toxin is a neurotoxin protein produced by anaerobic bacteria (clostridium botulinum) . it was first discovered by a german physician named justinus kerner who observed that the toxin acts by impeding signal transmission in the somatic and autonomic motor systems, leaving the sensory signal transmission uninterrupted . it blocked the acetylcholine release from the nerve endings thus prevent the neurological signals transmission at the neuromuscular junction. in turn, this reduces the muscle contraction and produces relaxation of the muscle . however, the clinical effects of botulinum toxin are transit as these neurotoxins degenerate at nerve terminals and became inefficient after a period of time . although numerous articles were published on the botulinum toxin a (bonta) injection in the management of mps, but there were diverse clinical results in the literature regarding this subject and its effectiveness is still questionable . the objective of this study was to evaluate the efficiency and outcomes of bonta injection in the management of mps related to masticatory muscles.

Eligibility criteria:
inclusion criteria: 1. patient with myofascial pain related to the muscles of mastication (masseter and temporalis muscle). 2. patient with regional pain. 3. patient with or without limited mouth opening (trismus). 4. presence of trigger points within the identified masticatory muscles. exclusion criteria: - 1. hypersensitivity to botulinum toxin. 2. active infection in the virtual points of injection. 3. patient with generalized musculoskeletal pain as in fibromyalgia syndrome (fms). 4. children younger than 12 years old and pregnant woman. 5-patient recently undergone to one other modality of treatment
differences in immunologic response to cryoablation versus radiofrequency ablation in the treatment of renal cell carcinoma

Conditions: Immune Response to 3 Approaches

Summary: the purpose of this study is to compare changes in the body's self-defense (immune response) after two different treatments for small kidney tumors: 1) cryoablation (freezing) therapy in which the tumor and a margin of normal kidney tissue are frozen and thawed twice with a needle probe and 2) radiofrequency ablation (rfa) in which radiofrequency energy delivered through a needle probe is used to heat tissue and thereby destroy a tumor.


Eligibility criteria:
inclusion criteria: * you are eligible to participate in this study if you are an adult (older than 18 years) * diagnosed with renal cell cancer 1-3 centimeters in size on the ct scan. exclusion criteria: * you are not eligible to participate in this study if you are immune compromised (chemotherapy,corticosteroid use, hiv \[as documented in your medical record\], etc.) * have an autoimmune disorders (rheumatoid arthritis, crohn's disease, etc) * have a tumor larger than 4 cm * are pregnant.
application of nasal cannula with oxygen versus air during eye surgery under local anaesthetic

Conditions: Hypoxia; Hypercapnia

Summary: the investigators hypothesize that this new nasal cannula will prevent lack of oxygen as well as reduce rebreathing of carbon dioxide under ophthalmic drapes during eye surgery.

surgery involvement the eye has widely been done under local anaesthesia provided by the ophthalmologists. patients are often awake or mildly sedated during the surgery. however, due to the surgical drape which covers the patients face and beyond in order to maintain sterility of the surgical field, it may lead to hypoxia in these patients and retention of exhaled air within the confined space under the drape. this may lead to patient discomfort and the surgeon will face difficulty when the patient becomes restless and unable to be still for the surgery. various studies had been conducted using nasal cannula with oxygen or air which is administered to patients having cataract surgery under local anaesthetics and the results has so far been inconclusive. one study evaluated the saturation of o2 in arterial blood, the partial pressure of o2 in arterial blood (pao2), the partial pressure of co2 in arterial blood (paco2) and the ph. the operative blood gas parameters were maintained in the air inhalation patients. oxygen supplement caused significant increase in the saturation of o2 in arterial blood and in pao2. there was no difference between the two groups in paco2. the ph of the arterial blood showed a statistically significant decrease in the patients with o2 supplement. this shift to more acidotic levels could cause central nervous system depression with reduced respiratory stimulus. recommendation was to administer air rather than o2 to patients during cataract surgery.\[1\] another clinical trials have shown that o2 application by nasal cannula prevents hypoxia but not rebreathing of co2 in patients undergoing eye surgery under local anaesthetics.\[4\] in this clinical trial, we use duo flow o2 + co2 sampling cannula designed in a way to deliver o2 and sampling of expired co2 gases from both nostril simultaneously. the aim of this study is to randomly administer o2 or air through a new nasal cannula to patients undergoing eye surgery under local anaesthetic and to evaluate the significance of o2 supplement and whether co2 retention has an indirect effect to it.

Eligibility criteria:
inclusion criteria: * (asa) physical status i, ii or iii, adult age 40-80 years old group, scheduled to undergo elective eye surgery under local anaesthetic at ummc will be enrolled in this study. exclusion criteria: * pre-existing pulmonary diseases, psychological disorders, neurological disorders and patients required sedation.

Keywords: hypoxia or hypercarbia during surgery under the drape
basal insulins - pharmacodynamics

Conditions: Diabetes

Summary: to purpose of this study is to compare the pharmacodynamic properties of insulin detemir, insulin glargine and nph insulin after a single subcutaneous injection.

in this randomized, double-blind, euglycemic glucose clamp study, 10 healthy male volunteers received a subcutaneous injection of 0.4 u/kg insulin detemir, insulin glargine or nph insulin on three separate study days in a cross-over design. after insulin administration, plasma glucose was maintained at 0.3 mmol/l below fasting level for 24 hours by manually adjusted glucose infusion. c-peptide, insulin, nefa and counter regulatory hormones were measured throughout the clamp period. endogenous glucose release (egr) was assessed by the isotope dilution technique (3-3h-glucose).

Eligibility criteria:
inclusion criteria: * male * bmi 20 - 50 kg/m2 * blood pressure \< 140/90 mmhg * signed informed consent * caucasien exclusion criteria: * diabetes or other disease * alcohol or drug abuse * smoking * use of prescription drugs

Keywords: levemir, lantus, insulatard, pharmacodynamics, healthy humans
validity and reliability of a low-cost chair dynamometer

Conditions: Spinal Cord Injuries

Summary: in part 1 of the study, fourteen able-bodied individuals will undergo maximal, voluntary contraction (mvc) test of the lower limbs in two dynamometers. one being a low-cost dynamometer (s2p-cd), and the other being a gold standard dynamometer (humac). thereby the investigators will be able to assess the validity of the s2p-cd. in part 2 of the study, eighteen persons with spinal cord injury will undergo mvc twice in the s2p-cd. thereby the investigators will be able to assess the reliability of the measurements of the s2p-cd.

in part 1 of the study, fourteen able-bodied individuals will undergo maximal, voluntary contraction (mvc) test of the lower limbs in two dynamometers. one being a low-cost dynamometer (s2p-cd), and the other being a gold standard dynamometer (humac). the tests will be carried out with 72-96 hours between them. thereby the investigators will be able to assess the validity of the s2p-cd. in part 2 of the study, eighteen persons with spinal cord injury will undergo mvc twice in the s2p-cd. participants will be recruited through the spinal cord injury centre of western denmark (sciwdk). the test will be carried out with 30min between them. thereby the investigators will be able to assess the reliability of the measurements of the s2p-cd.

Eligibility criteria:
ablebodied individuals: inclusion criteria: * age \>18 y exclusion criteria: * orthopedic or other injuries that may limit maximal muscle strength spinal cord injured individuals: inclusion criteria: * age \> 18 y * congenital or acquired spinal cord injury with some degree of preserved muscle function in the lower limbs exclusion criteria: * orthopedic or other injuries that may limit maximal muscle strength * significant competing diseases * severe osteoperosis