Kornimate/medical-research-clean huggingface dataset:
genes that affect disease progression in women with newly diagnosed or metastatic breast cancer

Conditions: Breast Cancer

Summary: rationale: studying samples of blood and tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in dna and help doctors understand how patients respond to treatment. purpose: this clinical trial is assessing how changes in genes affect disease progression in women with newly diagnosed or metastatic breast cancer.

objectives: primary * correlate inherited and acquired variations in candidate genes with breast cancer progression and survival in women with newly diagnosed or metastatic breast cancer. secondary * establish a repository of blood and tumor samples from these patients, linked to a database of clinical, pathological, and treatment outcome data for future research studies. outline: patients complete epidemiological questionnaires and undergo blood sample collection. tumor tissue specimens are requested from the pathology departments. blood samples are analyzed for single nucleotide polymorphisms and other polymorphic variants in candidate genes by polymerase chain reaction. candidate genes include genes involved in the dna damage response, programed cell death, inflammation, and angiogenesis. tumor samples are analyzed by tissue microarrays using immunohistochemistry, denaturing high-performance liquid chromatography, and dna sequencing to study genetic changes in the tumor. projected accrual: a total of 1,800 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * diagnosis of breast cancer * newly diagnosed or metastatic disease * resides within the north trent cancer network (ntcrn) region * undergoing therapy at ntcrn centers * hormone receptor status not specified patient characteristics: * female * menopausal status not specified prior concurrent therapy: * no concurrent participation in another genetic study

Keywords: stage iv breast cancer stage i breast cancer stage ii breast cancer stage iiia breast cancer stage iiib breast cancer stage iiic breast cancer
clinical trial of vildagliptin in early parkinson's disease

Conditions: Parkinson&#39;s Disease

Summary: investigating the efficacy of vildagliptin in delaying the progression of parkinson's disease.

exploring the effectiveness and safety of vildagliptin in delaying the progression of parkinson's disease.

Eligibility criteria:
inclusion criteria: * 1: patients aged 40 to 75 years who were diagnosed with parkinson's disease according to the uk brain bank criteria within the past three years. 2: participants must have received an optimized and stable dopaminergic medication regimen (dopamine agonists, levodopa, or monoamine oxidase b \[maob\] inhibitors, or combinations of these medications) determined by the study site investigators for at least one month prior to the baseline initiation of the trial drug, with the expectation that the participants will be able to continue this regimen for at least six months. 3: sign the informed consent form exclusion criteria: * 1: the key exclusion criterion is a score of at least 3 on the hoehn and yahr scale (ranging from 1 to 5, with higher scores indicating more severe disability), which indicates that parkinson's disease has led to at least mild to moderate bilateral motor involvement due to some postural instability. 2: presence of motor fluctuations or motor complications (or both). 3: the presence of severe psychiatric disorders, such as severe (treatment-resistant) anxiety, depression, or schizophrenia, that cannot be effectively controlled by medication. 4: atypical or secondary parkinsonism 5: a score of 18 or lower on the montreal cognitive assessment (moca) (range: 0 to 30, with a score of 26 or higher indicating normal cognitive function), indicating at least mild cognitive impairment. 6: diabetes mellitus (type 1 and type 2), as well as prior treatment with dipeptidyl peptidase-4 (dpp-4) inhibitors or glucagon-like peptide-1 (glp-1) receptor agonists. 7: individuals with severe renal impairment (creatinine clearance \<30 ml/min), active liver disease, history of drug or alcohol abuse, idiopathic pancreatitis, chronic pancreatitis, or a history of pancreatectomy. 8: individuals with a body mass index (weight in kilograms divided by the square of height in meters) less than 18.5, or those with a weight change exceeding 5 kilograms within the 3 months prior to screening. 9: currently participating in other relevant clinical trials involving pharmacological or surgical treatments. 10: other situations where the investigator believes that the subject is unable to participate in or cooperate with the entire assessment process of the clinical trial.
diastolic performance and norepinephrine in spinal-induced hypotension for cesarean delivery

Conditions: Hypotension

Summary: background and rationale: the best agent to prevent spinal-induced hypotension is still uncertain but norepinephrine showed fewer effects on heart rate and cardiac output. in septic patients norepinephrine has been shown to produce an "endogenous fluid challenge". objective: we aim to assess if patients with impaired diastolic function (46% of pregnant women at term) are less able to maintain indexed cardiac output in response to norepinephrine infusion during spinal-induced vasoplegia. we also aim to assess if fetal wellbeing is related to maternal cardiac output during spinal anesthesia for cesarean delivery. methods: we will assess by echocardiogram the diastolic function before surgery and will then start continuous non-invasive hemodynamic monitoring with a clearsight® monitor (clearsight®, edwards lifescience, irvine, ca) and perform a fluid challenge to relate diastolic disfunction with fluid responsiveness. hemodynamic monitoring will continue throughout the surgery. norepinephrine infusion will start concomitantly to beginning of spinal anesthesia and will stop 5 minutes after uterotonic medication. outcome: we aim to assess if patients with diastolic disfunction are less able to maintain cardiac output in response to norepinephrine infusion during spinal anesthesia induced vasoplegia. we also aim to assess if fetal wellbeing is related to maternal cardiac output during spinal anesthesia for cesarean delivery.)


Eligibility criteria:
inclusion criteria: pregnant women between the 36th and the 40th week of gestation undergoing spinal anesthesia for elective caesarian delivery. exclusion criteria: 1. age \< 18 yo; 2. preeclampsia; 3. eclampsia; 4. atrial fibrillation and sinus tachycardia; 5. cardiovascular diseases; 6. neuromuscular disease; 7. emergent or urgent cesarean delivery; 8. coagulopathies; 9. contraindications to spinal anesthesia.

Keywords: norepinephrine cesarean section spinal anesthesia
cardiovascular disease in black versus white physicians

Conditions: Cardiovascular Diseases; Coronary Disease; Heart Diseases; Hypertension

Summary: to examine the natural histories of coronary artery disease and hypertension in cohorts of black and white men of identical education and occupations.

background: prior studies of black-white differences in hypertension and coronary disease have compared racial groups from markedly different socioeconomic and educational backgrounds. this study represented one of a few, if any, long term prospective studies of cardiovascular disease in middle-class blacks and whites of similar education and occupation, in whom both youthful and midlife risk factors were assessed. design narrative: in this prospective study, the prevalence and incidence of coronary artery disease, hypertension, and other cardiovascular diseases were compared using standardized endpoint criteria. the prevalence of cardiovascular risk factors in midlife were compared between cohorts, and included smoking, diabetes, family history, dietary factors, and lipoprotein cholesterol levels. the youthful predictors of midlife cardiovascular risk factors were determined using baseline data collected by identical protocols in the two cohorts between 1957 and 1965. the youthful risk factors were related to the incidence of disease in midlife in two cohorts to identify differences in significance, independence, and relative importance of risk factors in blacks versus whites. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
biomarkers to predict hemorrhage and outcomes after endovascular treatment in patients with acute large vessel occlusion

Conditions: Acute Ischemic Stroke

Summary: the main aim of the biomarkers to predict hemorrhagic transformation(ht) after endovascular treatment in acute ischemic stroke patients. the study has three main parts. during the first part, the investigators propose to conduct an enrollment of patients after thrombectomy in acute ischemic stroke and healthy controls. serum biomarkers levels were analyzed (before and after) endovascular treatment patients and controls respectively. during the second part, ht was evaluated and classified on cranial computed tomography and/or mri post- treatment and was considered as symptomatic ht (sht) if associated with neurological deterioration. during the third part, the investigators aim to demonstrate the level of biomarkers can significant predict ht and outcomes in stroke patients undergoing revascularization.


Eligibility criteria:
inclusion criteria: 1. be 18 or older; 2. have a clinical diagnosis of acute ischemic stroke 3. a score of 6 or more points on the nihss(the national institutes of health stroke scale); 4. be scheduled to undergo intraarterial (ia) therapy for acute hemispheric stroke; 5. patients eligible for iv alteplase should receive iv alteplase; 6. intracranial arterial occlusion of the distal intracranial carotid artery, middle (m1/m2) ,anterior (a1/a2) cerebral artery,vertebral artery,basilar artery or posterior cerebral artery,demonstrated with cta, mra or dsa; 7. begin intra-arterial therapy within 24 hours of symptom onset; 8. have provided informed consent. exclusion criteria: 1. have any pre-existing illness resulting in a modified rankin scale score of 3 or higher prior to the qualifying stroke; 2. patients with known infectious, inflammatory, or neoplastic diseases at the time of treatment and non-availability of blood samples; 3. are pregnant.

Keywords: biomarker mechanical thrombectomy intracerebral hemorrhage acute ischemic stroke
cognitive behavior therapy for social media addiction, insomnia, and family relationship among individuals with social media addiction: a randomized control tria

Conditions: Cognitive Behavior Therapy for Social Media Addiction

Summary: objectives this study is designed to investigate the following objectives to manage the social media addiction in order to improve lifestyle, attitude and family relations of the individuals and explore related psychological problems which can arise because of this addiction. to explore the effectiveness of cognitive behaviour therapy (cbt) in the management of social media addiction in individuals which is decreasing the health of their lifestyle, attitude and family bonding. to explain how abusive use of social media can increase the risk of psychological and behavioural problems.

a sample of 150 individuals (male and female n=150) was recruited from different universities of faisalabad for the purpose. a strategy of non-probability sampling of purposive technique was used for the recruitment of sample. the age range for the sample will be 18-22 as young adults and adults was targeted. firstly individuals were screened out through social media addiction scale from which (n=60) participants were excluded because they did not meet the inclusion criteria of the study. some participants left because lack of interest. after excluding (n=60) from the study rest of the participants (n=90) were randomized and allocated to experimental (n=45) and control group (n=45). after allocation of participants in the relevant group some participants were lost from the follow up from experimental (n=21) due to decline to participate and control group (n=20) due to lack of interest. final analysis was conducted on experimental group and (n=24) control group (n=25) for the study.

Eligibility criteria:
inclusion criteria: * individuals screened out through social media addiction scale will be used for the experimental study. both male and female participants will be taken for the study. people with even mild score on social media addiction will be considered eligible for the study. only people in the age range of 18-22 will be taken as participants in the study exclusion criteria: * individuals not within the age range of 18-22 will not be taken as participants.

Keywords: social media addiction insomnia family bonding cognitive behavioral therapy
home-based pulmonary rehabilitation and health coaching in fibrotic interstitial lung disease

Conditions: Fibrotic Interstitial Lung Disease

Summary: the purpose of this study is to gather information on the effectiveness of a home-based pulmonary rehabilitation program with health coaching and tele-monitoring for improving patient-reported respiratory-related quality of life and physical activity in patients with fibrotic interstitial lung diseases (f-ild).

the home-based pulmonary rehabilitation program involves using a computer tablet paired with a pulse oximeter and activity tracker. gentle upper body exercises, walking and a breathing practice are completed by following along on the computer tablet. weekly check-in calls by telephone will be provided by a health coach to assess clinical status and monitor progress. the exercise portion of the program lasts 12 weeks. there are questionnaires and a research grade activity tracker measuring baseline and post-intervention findings at the end of 12-week period.

Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic pulmonary fibrosis (ipf) or other fibrotic interstitial lung disease, with a minimum of \> 10% fibrosis on computed tomography imaging. * clinically meaningful breathlessness: modified medical research council (mmrc) dyspnea score \>1. exclusion criteria: * inability to walk (orthopedic/neurologic/cardiac limitation causing immobility). * cognitive impairment or inability to understand and follow instructions. * traditional pr completed within 3 months of study recruitment. * hospice or end-of-life care at the time of screening. * acute exacerbation at the time of screening.
ultrasound-guided rectus sheath block for post-operative pain control following umbilical hernia repair

Conditions: Pain

Summary: the purpose of this study is to compare the effectiveness of local infiltration to an ultrasound guided nerve block placed by the anesthesiologist for children undergoing umbilical hernia repair. this is a double-cohort, double blinded, randomized study comparing local infiltration to ultrasound-guided rectus sheath block in children 1 to 17 years of age undergoing epigastric or umbilical hernia repair. we will first compare pain scores to see if one method is more adequate then the other in providing post-op analgesia. our second aim is to compare morphine consumption between the two groups. our third aim is to measure the levels of local anesthetic in the blood following local anesthetic infiltration or usgrsb.

healthy children, aged 1 to 17 years of age, undergoing elective umbilical hernia repairs will be considered for this study. after informed consent/assent has been obtained, the subject will be randomized into one of two groups. group a will receive local infiltration of 0.25% bupivacaine by the surgeon at the end of the subject's surgery. group b will undergo an ultrasound-guided rectus sheath block using 0.25% bupivacaine prior to incision by an anesthesiologist skilled in the performance of this block. all subjects will receive a standardized anesthetic for their surgery. subjects assigned to group a (local infiltration) will receive 2mcg/kg of fentanyl prior to incision for intra-operative pain management. subjects assigned to group b will have their rectus sheath block and no fentanyl will be given at this time. fentanyl is a short-acting opioid analgesic. it's duration of action in the dose we will be using is approximately one hour which is close to the expected length of surgery. therefore, it is not expected to influence the pain management after surgery. pain scores will be assessed by a member of the research team. they will be blinded to which technique the subject has been randomized to. this person will not be involved in the direct care of the subject. these observations will be made using an age-appropriate scoring system (flacc or faces scale). scoring will be done every 5 minutes when the subject is in the recovery room and every 30 minutes when they are in phase ii. this will be done until the subject is discharged from the hospital. families will be followed by phone for 48 h post discharge, to collect data on medication use.

Eligibility criteria:
inclusion criteria: * children between 1 ≤ 17 years of age * asa i (normal healthy children) and ii (children with mild systemic disease that has no functional effects) * having elective umbilical hernia repair exclusion criteria: * children \ 17 years of age * family has no telephone for follow up phone call * allergy or sensitivity to bupivacaine or morphine * any coagulation abnormalities * emergency surgery

Keywords: pain relief after umbilical hernia repair morphine consumption plasma bupivacaine levels
evaluation of novel lung function parameters in patients with interstitial lung disease (ild)

Conditions: Pulmonary Healthy Controls; Interstitial Lung Disease; Idiopathic Pulmonary Fibrosis; Non-specific Interstitial Pneumonia; Sarcoidosis; Granulomatosis With Polyangiitis (Wegener's Disease)

Summary: current diagnostic tools used in interstitial lung disease (ild) do not meet the challenges set by the complex pathophysiology of this heterogenous group. the investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of patients with various ilds.


Eligibility criteria:
inclusion criteria: * known or suspected interstitial lung disease exclusion criteria: * pregnancy * inability to participate
safety of cultured allogeneic adult umbilical cord derived mesenchymal stem cell intravenous infusion for ra

Conditions: Rheumatoid Arthritis

Summary: this trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of rheumatoid arthritis

studies have shown that stem cell treatment is safe and efficacious for the treatment of rheumatoid arthritis (ra). patients with ra will receive a single intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells. the total dose will be 100 million cells. patients will be evaluated within one month pre treatment and at 1, 6, 12, 24, 36, and 48 months post treatment for safety and efficacy. for patients with more severe disease requiring chemotherapeutic drugs such as methotrexate, an autologous t cell vaccine will be utilized created from the patient's own t cells obtained by apheresis

Eligibility criteria:
inclusion criteria: * diagnosis of rheumatoid arthritis * understanding and willingness to sign a written informed consent document exclusion criteria: * active infection * active cancer * chronic multisystem organ failure * pregnancy * clinically significant abnormalities on pre-treatment laboratory evaluation * medical condition that would (based on the opinion of the investigator) compromise patient's safety. * continued drug abuse * pre-menopausal women not using contraception * previous organ transplant * hypersensitivity to sulfur
a long-term study of the effects of orally administered sar302503 in patients with myelofibrosis

Conditions: Myelofibrosis

Summary: the purpose of this study is to evaluate the long-term effects of orally administered sar302503 (tg101348) in patients with myelofibrosis who have completed the mf-tg101348-001 study.

sar302503 (tg101348) is a potent small molecule inhibitor of janus kinase 2 (jak2). this is an extension study for a first-in-man, dose escalation study (mf-tg101348-001). the safety, tolerability and clinical activity of sar302503 (tg101348) in subjects with myelofibrosis will be evaluated.

Eligibility criteria:
inclusion criteria: * completion of mf-tg101348-001 study * diagnosis of myelofibrosis * at least 18 years of age exclusion criteria: * any acute or chronic medical abnormality that may increase the risk associated with study participation

Keywords: myelofibrosis
strengthening health and insight in new educators

Conditions: Anxiety Symptoms; Depressive Symptoms

Summary: teachers are at notable risk for depression and anxiety. the present study tests an app-based mindfulness intervention for teachers in their final year of training with the goal of preventing the deterioration of their mental health during the transition into the classroom. the project will strengthen the research environment at the university of alabama and will involve undergraduate research assistants in each step of the research process.

mental health concerns in teachers have escalated since the onset of the pandemic, and the deterioration of mental health can begin as early as the teacher training period. accessible and scalable programs that prepare teachers for the stress of the profession are urgently needed to prevent the deterioration of mental health and its attendant consequences. the goal of this longitudinal project is to test the feasibility and acceptability, utility, and candidate mechanisms of an accessible, mobile health, mindfulness-based intervention, the healthy minds program (hmp), to equip teachers in training ("pre-service teachers"; i.e., university students majoring in education) with skills necessary to maintain their mental health as they transition into the classroom. the project addresses three specific aims. aim 1: a) assess the feasibility and acceptability of the hmp for pre-service teachers and b) identify barriers and facilitators to program acceptability. aim 2: determine the utility of the hmp for preventing depression and anxiety (main outcomes) and turnover intentions (secondary outcome). aim 3: examine hmp effects on candidate mechanisms, and the effect of mechanisms on outcomes. the results of this project will provide critical insight into the potential for the hmp to scale up for widespread use in pre-service teacher training programs. importantly, the project will provide a unique opportunity for undergraduate research at the university of alabama, and will strengthen the research environment by involving undergraduate research assistants in each step of the research process.

Eligibility criteria:
inclusion criteria: * students in block 3 will be invited to participate in the study. exclusion criteria: * students who are not in block 3 will be excluded. participants experiencing suicidal ideations at baseline and deemed via the clinical risk assessment procedure to be at moderate or high risk of suicide will be excluded from the study after baseline, and prior to randomization.

Keywords: healthy minds program mindfulness-based intervention app pre-service teachers mental health