Kornimate/medical-research-clean huggingface dataset:
investigation of the acute effects of core stabilization and 360-degree breathing exercises on balance and proprioception in individuals with non-specific low back pain

Conditions: Low Back Pain (LBP); Exercise; Core Stability

Summary: this study is designed as a single-blind randomized controlled trial. male and female patients aged 18-65 years with complaints of non-specific low back pain (nslbp) lasting longer than 12 weeks will be included in the study. participants will be randomly assigned into two parallel groups: control and intervention. the control group will perform core stabilization exercises five days a week for three weeks. in the intervention group, core stabilization exercises will be combined with 360-degree breathing exercises. to our knowledge, there is no randomized controlled trial investigating the effect of combining core stabilization with 360-degree breathing in individuals with nslbp. the aim of this study is to examine the acute effects of combining 360-degree breathing techniques with core stabilization exercises on balance and proprioception in individuals with nslbp.

low back pain is a major health problem worldwide. non-specific low back pain (nslbp) is the most common form of back pain. the lifetime prevalence of back pain can reach up to 84%. various non-pharmacological and non-invasive methods are used for back pain management. one such method is core stabilization exercises. core stabilization exercises enhance trunk stability by activating the muscles around the spine and have the potential to improve balance in individuals with nslbp. this may help overcome balance disorders associated with pain and contribute to safer movements in daily life activities. breathing exercises, by activating the diaphragm muscle, support spinal stability and provide benefits in pain management. it is known that breathing supports trunk stability through its relationship with core muscles and strengthens balance mechanisms. studies in this field show that stabilization exercises can provide short-term improvements, especially in balance. however, the combined effects of core stabilization and breathing exercises in individuals with nslbp have not been fully investigated. therefore, this study aims to investigate the acute effects of combining 360-degree breathing exercises with core stabilization exercises on balance and proprioception in individuals with nslbp.

Eligibility criteria:
inclusion criteria: * low back pain persisting for at least 3 months * no neurological, rheumatological, or musculoskeletal system problems exclusion criteria: * individuals with neurological, vestibular, or serious orthopedic conditions that may cause physical disability * patients with back-leg or dorsolumbar pain due to lumbar disc protrusion or fracture * cancer patients * individuals with acute infections * individuals with respiratory system diseases * individuals with any mental disorder that would prevent participation in the study assessment * pregnant individuals

Keywords: core stability exercise low back pain exercise
precision of 3 dimensional facial analysis using bellus 3d face camera pro versus planmeca promax 3d proface: a diagnostic accuracy study

Conditions: 3 Dimensional Soft Tissue Facial Analysis

Summary: precision of 3 dimensional facial analysis using "bellus 3d face camera pro" versus "planmeca promax 3d proface" is to be evaluated in comparison to direct anthropometry.

the aim of this study will be the evaluation of the precision and reproducibility of standard anthropometric linear measurements made with two different three-dimensional imaging systems namely "bellus 3d face camera pro" and "planmeca promax 3d proface system" and to compare them to physical linear measurements "direct anthropometry".

Eligibility criteria:
inclusion criteria: 1. age range from 18-35 years. 2. normal balanced facial proportions. exclusion criteria: 1. craniofacial anomalies. 2. obvious skeletal shifts. 3. patients with incompetent lips.
btt1023 in psoriasis

Conditions: Plaque Psoriasis

Summary: patients with plaque psoriasis will be enrolled. they will be dosed with repeated intravenous doses of btt-1023 or placebo. during the trial, the safety of the treatments and the pharmacokinetics of btt-1023 will be assessed. the patient allocation to treatment groups will occur at random, and the actual treatment will not be revealed to the investigator or to the patient during the trial.


Eligibility criteria:
inclusion criteria: * plaque psoriasis affecting at least 8% of the body surface area and scoring 8 or higher in the psoriasis area and severity index exclusion criteria: * seropositive for infection with human immunodeficiency virus, hepatitis b virus, or hepatitis c virus; tuberculosis; acute systemic infection; * treatment with a monoclonal antibody therapy within 12 weeks prior to study entry; * an absolute indication for a known effective treatment

Keywords: plaque psoriasis btt1023 safety pharmacokinetics
role of perforator flaps in back defects reconstruction

Conditions: Myelomeningocele

Summary: evaluation of perforator flaps versus perforator plus flaps

one of the neural tube defects, myelomeningocele, is a congenital anomaly developing in the fourth gestational week. it is characterized by insertion of neural elements into a pouch floored by meninx through a vertebral defect. the aetiology is multifactorial. causes are genetic properties, geographic factors, and deficiency of folic acid. meningomyelocele incidence range between 1 and 2/1000 live births. the defect location can reside anywhere between the cervical region and the sacrum. surgical closure of the defect is performed to prevent cerebrospinal fluid leakage and central nervous system infections. it is a combined work between neurosurgery and plastic surgery. fascial turnover flaps, muscle flaps, local fasciocutaneous flaps. with the emerging concepts of perforator flaps in the last three decades, the reconstruction of myelomeningocele defects has completely changed since the anatomy of the dorsal intercostal artery perforators (diap) and lumbar artery perforators(lap) has been fully studied. despite utilizing perforator flaps having greatly improved the outcome of myelomeningocele reconstruction, venous compromise remained a major concern associated with complications. by preserving, the perforator vessels and minimizing the amount of tissue that is removed, the perforator plus technique can improve blood flow and decrease the risk of venous congestion. preoperative perforator mapping may be executed by a multitude of diagnostic modalities. hand-held doppler (hhd), color-coded duplex sonography (ccds), computed tomography angiography (cta), magnetic resonance angiography (mra) and others may be applied. systematic reviews of the literature revealed that ccds has the highest sensitivity and positive predictive value to identify perforators for flaps.

Eligibility criteria:
inclusion criteria: * infants up to one year, * dorso-lumbar myelomeningocele. * moderate to large myelomeningocele defects. (25 - 39 cm2 ) . exclusion criteria: * cervical myelomeningocele * very large defects (more than 40 cm2 ) * preterm newborn patients. * hematological disease * any problem against prone position of the patient

Keywords: myelomeningocele perforator flaps infants
comparison between laparoscopic ovarian diathermy and clomiphene citrate in women with anovulatory pcos

Conditions: Polycystic Ovary Syndrome

Summary: laparoscopic ovarian diathermy (lod) is currently offered to infertile women with polycystic ovarian syndrome (pcos) who fail to conceive on clomiphene citrate (cc). however, using lod before cc may result in a better reproductive outcome since lod may reduce risks associated with cc such as miscarriages and multiple pregnancies. the aim of the study is to evaluate the effectiveness of lod and its potential value in improving the success rates in infertile women with pcos. this study will recruit 72 women with pcos suffering from infertility due to lack of ovulation from the infertility clinic. after initial assessment, patients will be given explanation about the study and will receive an information leaflet. they will then be randomized into two groups: group1 (36 patients) will receive cc as per infertility clinic protocol to induce ovulation for up to 6 months. group 2 (36 patients) will undergo laparoscopic ovarian diathermy under general anaesthetic. blood samples will be taken from both groups before any treatment, shortly after treatment and at 3 and 6 months after treatment to measure various hormones. patients will be contacted every month after treatment for follow up. the reproductive outcomes particularly the pregnancy and livebirth rates will be compared between the two groups.


Eligibility criteria:
inclusion criteria: 1. age: 19 - 39 2. bmi \< 32 3. anovulatory infertility \> 1 year 4. diagnostic criteria for 5. no previous treatment for induction of ovulation 6. normal semen analysis of partner 7. proven patency of at least one fallopian tube exclusion criteria: 1. inability to give informed consent 2. contraindication to cc 3. contraindication to general anaesthetic or laparoscopy

Keywords: polycystic ovary laparoscopic ovarian diathermy induction of ovulation clomiphene citrate
study of grn163l with paclitaxel and carboplatin in patients with advanced or metastatic non small cell lung cancer

Conditions: Lung Cancer

Summary: the purpose of this study is to determine the safety and the maximum tolerated dose (mtd) of grn163l when administered in combination with a standard paclitaxel/carboplatin regimen to patients with advanced or metastatic non-small cell lung cancer.

grn163l is a telomerase template antagonist with in vitro and in vivo activity in a variety of tumor model systems. telomerase is an enzyme that is active primarily in tumor cells and is crucial for the indefinite growth of tumor cells. inhibition of telomerase may result in antineoplastic effects.

Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed diagnosis of nsclc * stage iiib with pleural effusion, stage iv, or recurrent disease * measurable or evaluable disease by recist criteria * ecog performance status 0-1 * adequate hepatic/renal function and platelet count * if previously treated with an anthracycline, anthracenedione, or trastuzumab, must have left ventricular ejection fraction \> 50% exclusion criteria: * more than 2 prior chemotherapy regimens for metastatic disease (prior adjuvant chemotherapy is allowed) * tumor progression during treatment with paclitaxel (refractory to paclitaxel) * taxane-based regimen within 12 weeks * any systemic therapy for cancer within 4 weeks * anti-platelet therapy within 2 weeks, other than low dose aspirin prophylaxis therapy * therapeutic anticoagulation therapy except for low dose warfarin (eg, 1 mg by mouth per day) * radiation therapy within 3 weeks * major surgery within 4 weeks (central line placement is allowed) * prolongation of pt or aptt \> the uln or fibrinogen \< the lln * history of or active central nervous system metastatic disease * any other active malignancy * active or chronically recurrent bleeding (eg, active peptic ulcer disease) * clinically significant infection * active autoimmune disease requiring immunosuppressive therapy * clinically significant cardiovascular disease or condition

Keywords: non small cell lung cancer advanced non small cell lung cancer metastatic non small cell lung cancer
glp-1's effect on cardiac parameters and mesenteric blood flow

Conditions: Healthy

Summary: to investigate the effect of the human incretin hormone glp-1 on mesenteric blood flow and cardiac parameters

to investigate the effect of the human incretin hormone glp-1 on mesenteric blood flow and cardiac parameters, in healthy subjects, 4 arms, task force monitor

Eligibility criteria:
inclusion criteria: * healthy subjects exclusion criteria: * medical conditions

Keywords: glp-1 blood flow cardiac out put stroke volume beat to beat effect of glp-1 on cardiac parameters and blood flow
splatt to peroneus brevis vs tatt to lateral cuneiform

Conditions: Recurrent Congenital Talipes Equinovarus

Summary: congenital talipes equinovarus, is a common congenital foot deformity involving hindfoot equinus and varus, along with mid-/forefoot adduction and cavus. currently, the ponseti method is the preferred initial treatment for idiopathic clubfoot1 . despite the initial phase's remarkable efficacy in correcting clubfeet, there remains a notable recurrence rate after ponseti treatment2 * numerous studies demonstrate a very high success rate during early follow-ups, ranging from 92% to 100%3 * nonetheless, recurrence remains a challenge for orthopedic surgeons. a common trigger for recurrence is the dynamic supination of the foot, which results from excessive activation of the tibialis anterior muscle during ankle dorsiflexion4 multiple studies indicate that tibialis anterior tendon transfer (tatt) is an effective tool for management of clubfoot recurrence, particularly dynamic supination5 * the widely used technique involves transferring the entire tendon through a drill hole in the lateral cuneiform and anchoring it on the plantar aspect of the foot using a sewing button and felt pad6 * while effective, this procedure raises the risk of pressure sores due to button placement on the sole7 split anterior tibialis tendon transfer (splatt) to peroneus brevis is a well-described treatment strategy of varus foot deformities in patients with neuromuscular disorders8 * the technique has been reported to achieve successful deformity correction while avoiding skin problems associated with external button placement on the sole of the foot in tendon-to-bone transfers8 the present study aims to assess the outcome of utilizing splatt to peroneus brevis procedure in the treatment of recurrent ctev in comparison to the original total tatt to the lateral cuneiform


Eligibility criteria:
inclusion criteria: * recurrent ctev * age between 4 years and 12 years * unilateral/bilateral * ankle dorsiflexion of at least 10° prior to tendon transfer exclusion criteria: * non idiopathic ctev * rigid deformity not suitable for acute correction * poor skin condition
pathogenesis of the cardiometabolic risk in youth with type 1 diabetes

Conditions: Type 1 Diabetes; De Novo Lipogenesis

Summary: the purpose of this study is to quantitate hepatic de novo lipogenesis (dnl) in youth with poorly-controlled type 1 diabetes (t1d) (hba1c \>8.5%), youth with t1d who achieve targeted glycemic control (hba1c \<7.5%) and lean controls. hypothesis: youth with poor glycemic control experience higher fractional hepatic dnl during the fasting and the postprandial states than youth who achieve targeted glycemic control and lean controls.

what is not known, is whether hepatic de novo lipogenesis (dnl) contributes to dyslipidemia in this in patients with type 1 diabetes (t1d). the aim of the study is to test the hypothesis that an enhanced rate of dnl largely contributes to dyslipidemia occurring in youth with poorly-controlled t1d. according to this hypothesis, youth with poorly-regulated t1d experience a state of persistent insulin independent, highly variable fluctuations of glucose, and other sugars, through the glycolytic pathway that result in an enhancement of hepatic dnl and an increased production of triglycerides (tg). newly-formed tg are packaged into large-vldl that are secreted into the circulation contributing to an increase in plasma tg. when the tg concentration in the hepatocytes exceeds the ability of the liver to secrete tg, the latter start accumulating leading to hepatic steatosis.

Eligibility criteria:
inclusion criteria: * hba1c \>8.5% for the group with poorly controlled diabetes * hba1c \<7.5% for the well-controlled patients * t1d for at least 12 months (t1d groups only) * negative pregnancy test (all groups) exclusion criteria: * baseline creatinine \>1 * being on medications affecting glucose concentrations other than insulin * positive pregnancy test * endocrinopathies
a follow-up study to evaluate the efficacy and safety of novomax in posterior lumbar interbody fusion

Conditions: Degenerative Lumbar Spinal Stenosis

Summary: this is a long-term follow-up study for more than 3 years to evaluate the efficacy and safety of bioactive glass-ceramic intervertebral spacer (novomax) in posterior lumbar interbody fusion.

during one-level plif, bioactive glass-ceramic intervertebral spacer (novomax) and titanium cage were inserted in the experimental group and control group, respectively. bone fusion by simple radiography had angular deformity of less than 3 degrees and a potential of less than 3 mm in flexion extension radiographs, and thin-section ct (\<2 mm) was used to determine the combination between the vertebral endplate and the autogenous bone or bioactive glass-ceramic intervertebral spacer (novomax) in the cage without any gaps or the part connected to bony trabecula as fusion, and both groups will be compared.

Eligibility criteria:
inclusion criteria: \[in interventional study\] * subjects who required between l1 and s1 among those who required an extensive laminectomy or facetectomy to correct severe disc extrusion or severe spinal stenosis or those who required plif due to grade i or ii spondylolisthesis \[in long-term follow-up study\] * subjects who are treated with bioactive glass ceramic intervertebral spacer or titanium cage in one-level plif surgery exclusion criteria: \[in interventional study\] * subjects with average t-scores of l1-l4 at \<-3.0 in dexa bone density tests * subjects who are pregnant or breast-feeding * subjects with a history of malignant tumor or malignant diseases (but the cases of cured disease with no relapse for the past 5 years were included in the present study) * subjects with abnormal blood potassium and phosphorus levels * subjects who are considered not suitable for the study by significant disease(liver disease, kidney disease, respiratory disease, metabolic disease, or psychological disease) * subjects who are not able to comply with the study requirements * subjects who are considered not suitable for the study by the investigator \[in long-term follow-up study\] * subjects who are not able to comply with the study requirements * subjects who are considered not suitable for the study by the investigator
comparison of the oblique-axis and long-axis approaches for axillary vein catheterization under ultrasound guidance

Conditions: Central Venous Catheterization

Summary: ultrasound-guided axillary vein catheterization can be performed via the oblique-axis and long-axis approaches of the axillary vein. the aim of our study is to compare the first puncture success rate and safety between the two approaches of ultrasound-guided axillary vein catheterization in cardiac surgical patients with high bleeding risk

for patients after cardiac surgery, antiplatelet drugs or anticoagulants are usually used for preventing thrombosis. use of those drugs is associated with increased risk of bleeding. any invasive procedures may put those patients at additional risk of bleeding. ultrasound (us) has become widely accepted to guide safe and accurate central venous catheterization. ultrasound-guided axillary vein catheterization can be performed via the oblique-axis and long-axis approaches of the axillary vein. the aim of our study is to compare the first puncture success rate and safety between the two approaches of ultrasound-guided axillary vein catheterization in cardiac surgical patients with high bleeding risk

Eligibility criteria:
inclusion criteria: * cardiac surgical patients in cardiac surgery intensive care unit * axillary vein catheterization is needed according to the clinical practice exclusion criteria: * the proximal and/or distal axillary vein was not clearly visualized or potentially unavailable for catheterization; * did not receive or had not received oral antiplatelet drugs and/or anticoagulants for less than 3 days; * already had presence of subclavian or axillary vein catheter; * required an emergency axillary vein catheterization; * had fracture of the ipsilateral clavicle or anterior proximal ribs; * had subclavian and/or axillary vein thrombosis; * had local infection of the puncture area.

Keywords: axillary vein central venous catheterization ultrasound cardiac surgery complication
vcom pain free research

Conditions: Chronic Pain

Summary: studies estimate that 30% of people worldwide experience chronic pain. the mechanisms causing this pain can vary: a neuropathic offender, such as nerve compression; a structural offender, such as long-term effects of soft tissue damage and repair; or nociplastic, dysfunctional offenders, such as fibromyalgia. the type of pain experienced influences diagnostic and treatment choice. in theory, there's a significant blending of these pain types within individuals and across patients, leading many specialists to view pain classification as a spectrum. multidisciplinary pain management (mpm) is a standard model for addressing and treating different mechanisms of chronic pain using multiple interventions from different disciplines. although many clinics employing these strategies have resulted in positive and clinically effective outcomes, the creation and implementation of such facilities have not been widespread. with increasing focus on psychosocial factors that impact pain in conjunction with structural and biomechanical offenders, a need for a whole-person, integrated approach to chronic pain management is needed. we propose an observational study to gather data that will inform the design, implementation, and operation of such a chronic pain research clinic.


Eligibility criteria:
inclusion criteria: * those experiencing chronic pain, i.e., ongoing pain not relevant to an acute perturbation (e.g., recent injury). exclusion criteria: * those subjects seeking pharmaceutical intervention * those whose myofascial pain is deemed functional (normal response to acute injury or ongoing pathology

Keywords: autonomic dysfunction sympathetic dominance osteopathic manipulative treatment dry needling nutrition lifestyle group therapy therapy trauma flourishing