Kornimate/medical-research-clean huggingface dataset:
does fluorescence with or without indocyanine green improve parathyroid identification and preservation

Conditions: Parathyroid Dysfunction; Adenoma

Summary: the aim of this study is to determine if fluorescence with or without indocyanine green can facilitate safe and accurate thyroid and parathyroid surgery.

the accurate identification of the parathyroid gland is a crucial aspect of thyroid and parathyroid surgery. failing to recognize the parathyroid gland during thyroidectomy can result in the inadvertent removal of the gland, leading to postoperative hypocalcemia. on the other hand, during parathyroidectomy, there is a risk of mistaking other structures, such as lymph nodes, for parathyroid adenomas, which can leave the patient without a cure. currently uab employs intraoperative pth or radioactive isotope techniques in conjunction with surgeon judgment. however, both methods have limitations, including being time-consuming, posing logistical challenges, and not providing feedback before gland removal. parathyroid fluorescence is a relatively new technology. it was initially discovered that the parathyroid gland emits fluorescence, which distinguishes it from the surrounding tissues. additionally, indocyanine green dye is readily taken up by the parathyroid gland, making its detection easy to the naked eye. research has demonstrated that parathyroid fluorescence, with or without indocyanine green, is not only safe but also helps reduce postoperative hypocalcemia and locate lesions in patients with imaging-negative parathyroid adenomas. however, the current use of parathyroid fluorescence is not standardized, and further studies are needed to explore its clinical utility in terms of cure rates and postoperative complications.

Eligibility criteria:
inclusion criteria: * age greater than 18 years old exclusion criteria: * patients with iodine or shellfish allergies would be excluded. * patients with allergy to indocyanine green. * pregnancy

Keywords: indocyanine green parathyroid surgery
role of local skin incision infiltration by oxytocin on wound healing

Conditions: Wound Heal; Scar; Previous Cesarean Section

Summary: caesarean section rate in egypt has reached about 60% between primgravidae. wound complications are of the most common morbidities following cesarean section. the prevalence of wound infection and disruption after cesarean has been reported as 3-15%, averagely speaking 6% and 2-42% in various studies. these complications affect mother's quality of life due to stress, anxiety, delay in mother's ability and health recovery

nowadays, cesarean is one of the most common surgical interventions and its prevalence has increased in most countries in the recent years. at present, all efforts are focused on the early and effective healing of caesarean skin wound and its associated complications. there is a wide range of topical and systemic treatments for the management of caesarean skin incision. topical treatments have side effects and hence are not considered as the treatment of choice for such incisions. oxytocin is a nonapeptide hormone of a cyclic six amino-acid structure and a tail of three amino acids, responsible for initiation of the milk ejection reflex and stimulating the uterine contractions. however, other important roles of oxytocin include improvement of social life, exerting pain-relieving, anti anti-stress/anti-inflammatory and restorative effects, friendship and making social relationship with individual or group. however, other important roles of oxytocin include improvement of social life, exerting pain-relieving, anti anti-stress/anti-inflammatory and restorative effects, friendship and making social relationship with individual or group. in conclusion, oxytocin is linked to many different, sometimes opposite effects the intact cyclic molecule may act to initiate social interaction and associated psychophysiological effects, whereas linear oxytocin and c-terminal fragments may induce relaxation and anti-stress effects following social interaction. in this way, the principal hormone oxytocin and its fragments may take part in a behavioral sequence, ranging from approach and interaction to calm and relaxation. linear fragments, with an exposed cysteine-residue, may exert anti-inflammatory and antioxidant effects and thereby contribute to the health-promoting effects of oxytocin.

Eligibility criteria:
inclusion criteria: * primigravidae women, * age group from 20- 35 years old. * gestational age 37-41 weeks, and * elective caesarean section due to obstetrics indication. * the patient signed an informed consent form authorizing their inclusion exclusion criteria: * multiparous women, * assisted vaginal delivery, * normal vaginal delivery, * emergency caesarean section, * preterm pre labour rupture of membrane, * primiparous women with age above 35 years old, * primiparous women with known connective tissue disease and * women suffering from chronic diseases such as diabetes, hypertension, cardiovascular diseases, psychiatric diseases, cancer * smoking women

Keywords: wound healing oxytocin caesarean section scar wound complications
role of rdw as anon invasive index for predicting liver cell failure and portal hypertension in cirrhotic patient

Conditions: Predicting Liver Cell Failure & Portal Hypertension in LC

Summary: role of rdw as anon invasive method for predicting liver cell failure \& portal hypertension in cirrhotic patient

red blood cell distribution width (rdw) is a measure of the range of variation of red blood cell (rbc) volume. the rdw-sd (standard deviation ) is an actual measure of size. normal reference range of rdw-sd in adult human is 39-46 fl .liver plays an important role in removing body toxins which affects rbcs ,so liver cirrhosis may affects the rdw. cirrhosis is a chronic degenerative disease in which irreversible scarring of the liver occurs. it leads to liver failure. child's score is used as an indicator for liver cell function portal hypertension is an increase in the blood pressure within the portal venous system .obstruction to blood flow that occurs in liver due to fibrosis and regenerating nodules reduce flow from the portal veins into the hepatic veins. it also impedes hepatic artery flow from the branches that feed into the sinusoids. this increase in arterial resistance leads to an increase in arterial flow into the portal vein via producing a new anastamosis. the net result of that is an increase in portal vein pressure and dilatation of portal vein. direct measurement of portal pressure is invasive, inconvenient, and clinically impractical. the hepatic venous pressure gradient (hvpg) is used to measure portal pressure .recently, portal vein diameter is used as indicator for portal hypertension .

Eligibility criteria:
inclusion criteria: the study will include a total of 100 patient in assiut university hospital diagnosed to be cirrhotic by abdominal us. they will be divided into 3 groups according to child's score (a,b,c) exclusion criteria: * evidence of iron deficiency anaemia * patients within one month of hematemesis * thalassaemia
linezolid plus standard of care

Conditions: Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)

Summary: the aim of the study is to assess whether targeting virulence factors by administering linezolid in addition to standard antibiotic treatment improves outcomes in patients with staphylococcus aureus bacteraemia.

staphylococcus aureus (s. aureus) is one of the deadliest bacterial pathogens, especially in high-income countries, and causes bloodstream infections (bacteraemia) in 20-30 per 100,000 people annually. despite widely available antibiotic treatments, the 90-day mortality rate remains high at 20-30%, and complications such as organ damage, relapses, and long-term impairment affect many survivors. existing treatments have failed to improve survival rates highlighting the urgent need for novel therapeutic strategies. virulence factors produced by s. aureus facilitate bacterial persistence and spread, and tissue damage. preclinical research suggests that inhibiting the production of virulence factors may improve patient outcomes. while some clinical guidelines recommend this approach for toxin-mediated infections, randomized controlled trials (rcts) evaluating this approach in s. aureus bacteraemia have not yet been conducted. linezolid, an antibiotic commonly used for pneumonia and complicated skin and soft-tissue infections, has shown strong inhibition of the expression of s. aureus virulence factors in preclinical studies. studies in animal models demonstrated that linezolid, when combined with other antibiotics, enhances treatment efficacy and reduces bacterial toxin production. observational studies suggest that early initiation of linezolid may lead to better patient outcomes, but no rct has tested this approach in s. aureus bacteraemia. this placebo-controlled trial will evaluate whether adding a 5-day course of linezolid to standard antibiotic therapy improves clinical outcomes in patients with s. aureus bacteraemia.

Eligibility criteria:
inclusion criteria: * staphyloccus aureus (s. aureus) grown from at least one blood culture * hospitalised at a participating centre * ≥18 years old * written informed consent exclusion criteria: * administration of the initial drug treatment not feasible within 72 hours since the collection of the first positive blood culture with s. aureus * documented history of positive blood cultures for s. aureus occurring between 72 hours and 180 days prior to the eligibility assessment * necrotising fasciitis * currently receiving linezolid or clindamycin * previous type 1 hypersensitivity reaction to linezolid * current severe thrombocytopenia (i.e. \<30 x 10\^9/l) * application of study drug not possible (per mouth or per gastric tube) * local treating team believes that death is imminent and inevitable * patient is receiving end of life care and antibiotic treatment is not considered appropriate * local treating team believes that participation in the study is not in the best interest of the patient

Keywords: virulence factors linezolid bloodstream infection hierarchical composite endpoint staphylococcus aureus bacteremia bacteraemia mrsa pssa mssa
elasticity of structures around the ankle in chronic ankle instability

Conditions: Chronic Ankle Instability

Summary: the aim of this study is to examine the flexibility of the structures around the ankle in individuals with unilateral chronic ankle instability. individuals between the ages of 18-45 who have been diagnosed with chronic ankle instability by an orthopedist and who have unilateral instability will be included in the study. the flexibility of the healthy and instability sides will be evaluated. demographic information of the individuals will be recorded and clinical evaluations will be made. the severity of ankle instability will be evaluated with the functional ankle identification (fabit). the foot posture of the individuals participating in the study will be evaluated with the foot posture index, and the degree of flat feet will be evaluated with the navicular drop test. the flexibility of the gastrocnemius, tibialis anterior, peroneus longus, achilles tendon and plantar fascia of the individuals participating in the study will be measured with a myotonometer.


Eligibility criteria:
inclusion criteria: * ages 18 to 45 * mini mental state exam (mmse) score of 24 to 30 * diagnosed with unilateral chronic ankle instability by a physician exclusion criteria: * inability to communicate verbally * use of a walking aid * any history of lower extremity surgery * people with severe visual impairment, neurological disorders and/or congestive heart failure.
comparison of the additional effects of using tens and interferential currents for the treatment of individuals with chronic nonspecific neck pain.

Conditions: Neck Pain; Chronic Pain

Summary: in the current clinical and scientific reality, conservative treatment is the most coherent clinical management with a view to the proper rehabilitation of patients with chronic neck pain, with a trend towards the use of therapeutic exercise. however, some uncertainty about the effectiveness of therapeutic exercises still remains, requiring further studies with high methodological rigor, especially with regard to multimodal treatment, such as the combination of therapeutic exercises with photobiomodulation. thus, the objective of this project is to evaluate the effects of adding photobiomodulation to a program of specific therapeutic exercises for the treatment of individuals with chronic non-specific neck pain. to this end, 60 participants will be randomized into three groups: therapeutic exercise group + photobiomodulation (n = 20), and therapeutic exercise group. there will be 8 treatment sessions and participants will be evaluated before, after the 8 sessions, and 4 weeks after the end of treatment using the numerical pain scale, neck disability index, catastrophic thoughts about pain scale, and tampa kinesiophobia scale. in the statistical analysis, a linear mixed model will be applied, considering the interaction between the time and group factors. finally, the addition of photobiomodulation to a therapeutic exercise program is expected to generate clinical improvements for patients with chronic neck pain.


Eligibility criteria:
inclusion criteria: * with chronic neck pain (for more than 90 days) * identified according to the following criteria: ndi score ≥ 5 * numerical pain scale (end) score ≥ 3 at rest or during active neck movement exclusion criteria: * individuals who had a history of cervical trauma; head, face, or cervical surgery * degenerative diseases of the spine * pain radiating to the upper limbs * having been submitted to physiotherapeutic treatment for the cervical region in the last three months * use of analgesics, anti-inflammatory drugs, or muscle relaxants in the last week; the presence of systemic diseases * medical diagnosis of fibromyalgia.
effect of preload on bladder retention volume during spinal anesthesia

Conditions: Diuresis; Bladder Retention Volume; Hypotension

Summary: the purpose of this study is to assess the influence of different fluid infusions on the quantity of bladder retention after spinal anesthesia. this study should determine if this increase in bladder retention is significant and relevant.

background of the study: spinal anesthesia , through interruption of spinal nerve conduction, causes intense blockade of sensation, motor function as well as (para)sympathetic function. loss of sympathetic tone causes vasodilation which may lead to arterial hypotension and bradycardia. to avoid these effects, in anesthetic practice, usually intravenouspreload is administered as cristalloids or colloids. the form and dosage of these plasma expanders will influence diuresis during spinal anesthesia-induced detrusor blockade. excess diuresis may cause bladder distension and neccecitates bladder catheterization objective of the study: to compare the quantitative effects of ringer lactate and hes 6% on diuresis during spinal anesthesia-induced detrusor blockade as well as prevention of hypotension and vasopressor use. study design: before spinal anesthesia is performed, patients are randomized into one of the 3 study groups (no preload, preload with ringers' lactate 14 ml/kg, preload with hes 6% 7 ml/kg). spinal anesthesia is administerd with lidocaine 2% 70mg. hypotension is treated with vasopressors, atropine or additional intravenous fluid. bladder scans will be performed on the recovery unit and day-case unit. total urinary volume is measured until sensory function at dermatome s2/3 is restored and spontanous voiding is possible. study population: asa 1-2 patients who present for spinal anesthesia for minor surgery on the lower extremitiy. age 18-60 years. intervention (if applicable): prespinal administration of intravenous ringers' lactate 14 ml/kg or hes 6% 7 ml/kg. primary study parameters/outcome of the study: primary outcome is total urinary volume during spinal induced detrusor blockade, and number of subjects that have a bladdder volume over 500ml. secundary study parameters/outcome of the study (if applicable): secondary outcome parameters: periods of hypertension, and total dose of vasopressor en extra fluid administration. nature and extent of the burden and risks associated with participation, benefit and group relatedness (if applicable): except for extra bladderscan and block height measurements, all actions are part of routine anesthesiologic care. ga naar boven

Eligibility criteria:
inclusion criteria: * asa1-2 * undergoing minor procedure under spinal anesthesia exclusion criteria: * asa3-4 * history or signs of heart failure / coronary artery disease. * bladder / urinary disease * neurologic disease that may affect bladder function

Keywords: spinal anesthesia preload diuresis bladder retention
pediatric facial fracture study

Conditions: Craniofacial Fracture

Summary: the goal of this study is to establish a prospective, long-term, comprehensive growth and development study of the pediatric craniofacial skeleton following fracture, whose recruitment is ongoing.

this is a prospective, long-term, comprehensive growth and development study of the pediatric craniofacial skeleton following fracture. this study will encompass two specific aims: 1. to compare the growth and development of the pediatric craniofacial skeleton after fracture to publish standardized means of dentofacial growth in the bolton-brush growth study. patients will be matched according to age, gender, and ethnicity. the status of dental eruption will be recorded as well as the vertical and anteroposterior classification of occlusion. the effect of trauma on the eruption and vitality of permanent teeth will be recorded. we will further assess the popularly held theories of craniofacial growth and effects of injury to various facial growth sites (i.e. mandibular condyles, nasal septum). 2. attempt to evaluate the effects of various treatment modalities of facial fracture on skeletal growth and development (i.e. open reduction and internal fixation versus closed reduction and external fixation), (open reduction and internal fixation with metallic vs. absorbable fixation). we will evaluate the effect of metallic internal fixation on subsequent craniofacial skeletal growth and development, as well as the routine needed for its removal.

Eligibility criteria:
inclusion criteria: * criteria for inclusion in the research study will be any pediatric patient, birth to 18 years, who are in the active phase of craniofacial skeletal growth, and have sustained a craniofacial fracture. * the racial, gender and ethnic characteristics of the proposed subject population reflects the demographics of the university of pittsburgh and the surrounding area and/or the patient population of the university of pittsburgh medical center. * the investigators shall attempt to recruit subjects in respective proportion to these demographics. no exclusion criteria shall be based on race, ethnicity, gender or hiv status. exclusion criteria: * criteria for exclusion in the research study will be any pediatric patient, birth to 18 years, who are not in the active phase of craniofacial skeletal growth, and have not sustained a craniofacial fracture.

Keywords: craniofacial fracture subjects who are in the active phase of craniofacial skeletal growth, and have sustained a craniofacial fracture
fetuin a association in periodontal disease and diabetes mellitus

Conditions: Periodontitis, Adult

Summary: aim: the aim of the current study was to compare and correlate gingival crevicular fluid (gcf) fetuin-a levels and high sensitivity c-reactive protein (hs-crp) levels in non-diabetic periodontitis patients and type 2 diabetic periodontitis patients with healthy subjects and revealing its possible role in diagnosis of periodontal disease. methodology: forty-five periodontitis stage iii patients categorized into 3 groups according to whether having type ii diabetes mellitus or not were compared to systemically and periodontally healthy participants in this investigation. clinical parameters for all groups were recorded. assessment of gcf levels of fetuin a and hs-crp were done to all enrolled participants utilizing an enzyme linked immune-sorbent assay (elisa) kit. receiver operating characteristic (roc) curve was performed to reveal sensitivity, specificity, predictive value and diagnostic accuracy of the markers used.


Eligibility criteria:
inclusion criteria: * both gender periodontitis stage iii exclusion criteria: 1. smoking, 2. systemic diseases (except dm in group b), 3. periodontitis patients having periodontal treatment recently (past 6 months), 4. pregnancy, lactation, contraceptive pills, 5. anti-inflammatory/ immunosuppressive drugs.
vr system for cross-modal rehabilitation of hemianopia

Conditions: Hemianopia, Homonymous; Hemianopsia, Homonymous

Summary: the purpose of this research study is to investigate the effectiveness of a new rehabilitation for visual hemianopia. the study team believes a cross-modal rehabilitation technique delivered by a virtual reality system can help restore the visual field for subjects with homonymous hemianopia.

the study tests a novel rehabilitation system, translated from promising cross-modal rehabilitation animal research, that is the first treatment capable of restoring the visual field for hemianopia patients. this noninvasive technique uses a virtual reality device to deliver visual and auditory stimulus. the goals of this study are to obtain proof of concept and procure rehabilitation data to support the development of this novel rehabilitation treatment.

Eligibility criteria:
inclusion criteria: * adult volunteers diagnosed with homonymous visual hemianopia / hemianopsia (ages 18-99) exclusion criteria: * volunteers who are unable to complete the study tasks or understand instructions * subjects that are not able to provide written consent or verbal assent * subjects who are not available to complete all rehabilitation sessions

Keywords: hemianopia virtual reality rehabilitation hemianopsia
pyrosequencing of the brafv600e mutation

Conditions: Thyroid Neoplasms

Summary: to investigate the diagnostic efficiency of pyrosequencing for the mutant braf allele in ultrasound (us)-guided fine needle aspiration biopsies (fnab) of thyroid incidentalomas.


Eligibility criteria:
inclusion criteria: * patients with thyroid nodule larger than 1 cm, or nodule smaller than 1 cm that required further evaluation because of suspicious ultrasound findings exclusion criteria: * patients who refuse participation.

Keywords: pyrosequencing brafv600e mutation thyroid incidentaloma ultrasound-guided fine-needle aspiration biopsy