Kornimate/medical-research-clean huggingface dataset:
youth mayo clinic anxiety coach pilot study

Conditions: Anxiety

Summary: this research study aims to test the feasibility and effectiveness of using the mayo clinic anxiety coach smartphone app as an addition to traditional therapy for the treatment of anxiety disorders in youth, particularly those youth who may have limited access to mental health treatment in the traditional clinical setting.

this research study aims to test the feasibility and effectiveness of using the mayo clinic anxiety coach smartphone app as an addition to traditional therapy for the treatment of anxiety disorders in youth, particularly those youth who may have limited access to mental health treatment in the traditional clinical setting. therapist will provide cbt to patients with infrequent face-to-face contact and then will examine the acceptability, ease of use and need for contact.

Eligibility criteria:
inclusion criteria: 1. age 7 to 17 2. primary diagnosis of: 1. social phobia, 2. separation anxiety disorder, 3. panic disorder with and without agoraphobia, 4. specific phobia, or 5. obsessive compulsive disorder 3. a parent or other primary care giver available to participate with the child in all assessment and treatment activities 4. estimated average intelligence 5. english speaking exclusion criteria: 1. history of and/or current diagnosis of: 1. psychosis, 2. autism, 3. bipolar disorder, 4. mental retardation, 5. oppositional defiant disorder, 6. ptsd, 7. selective mutism, or 8. major depressive disorder 2. current suicidality or recent suicidal behavior 3. parent to be involved in study who is unable to adequately participate due to intellectual or psychiatric difficulties 4. starting or changing the dosage of a psychiatric medication in the last two months

Keywords: anxiety social anxiety social phobia separation anxiety generalized anxiety gad phobia panic agoraphobia obsessive compulsive disorder ocd child adolescent smartphone teen youth
short- and long-term renal outcomes following lung transplantation

Conditions: Lung Transplantation; Acute Kidney Injury

Summary: evaluation of acute kidney injury, renal recovery and development of chronic kidney disease in patients undergoing lung transplantation

it is well described that acute kidney injury and development of chronic kidney disease significantly impact short- and long-term survival after lung transplantation. however, there is limited data about prevalence of kidney disease according to current kdigo consensus guidelines. it is the aim of this study to describe short- and long-term renal outcomes following lung transplantation. selected patients who underwent prospective pretransplant renal functional reserve testing with high oral protein load will be analyzed separately in respect to occurrence of acute kidney injury following lung transplantation and development of chronic kidney disease.

Eligibility criteria:
for retrospective analysis for all patients undergoing lung transplantation: inclusion criteria: * older than 18 years exclusion criteria: * patients with egfr \<15ml/min/1.73m2 or with chronic dialysis treatment prior ltx * patients undergoing retransplantation and multiorgan transplantation for prospective study involving patients with pretransplant renal functional reserve testing exclusion criteria: * as above * unable to perform renal functional reserve testing (e.g., due to critical illness) * pre-existing acute kidney injury
the smart-phone as a physical fitness monitor - validity, sensitivity and motivation interwalk

Conditions: Type 2 Diabetes

Summary: low physical fitness may cause several life style related diseases e.g. cardiovascular disease, cancer and type 2 diabetes. it is important to develop reliable methods for measurement which can be used to follow the development of the physical shape both on an individual level and on at population level. associated with the development of new training method known as interval walking we developed an application for smartphones. the use of the application interwalk was meant to increase physical activity in patients with type 2 diabetes. the application should both be able to, 1) be a personal trainer when doing interval walking, and 2) measure the individual physical fitness performed as a walking test. the latter function was developed to make the training more personal and individal adapted, so that the training was neither too hard or too easy. it is necessary to test the walking test against a golden standard for measuring physical fitness and that the test in the application is able to measure and register changes in physical fitness. our hypothesis is that the individual test, in the interwalk application is reliable and able to register changes in physical fitness in patients with type 2 diabetes. the purpose of this project is investigate the reliability of a smartphone-based test of physical fitness, and to investigate whether the test is able to register changes in physical fitness during the project time (3 month). a secondary aim is to investigate whether individual support during the training period, affect the individual effort and time of interval walking per week.


Eligibility criteria:
inclusion criteria: * type 2 diabetes, age 30-80 y, bmi \>18 but \<40 kg/m2 and confirmed t2d diagnose exclusion criteria: * pregnancy, smoking, contraindication to increased levels of physical activity, insulin dependence, evidence of thyroid, liver, lung, heart or kidney disease

Keywords: type 2 diabetes, interwalk, individual support, motivation
nutritional interventions in patients with alcohol-associated hepatitis

Conditions: Alcoholic Hepatitis

Summary: alcohol-associated hepatitis (ah) is a life-threatening condition with high 90-days mortality (up to 40%) and limited treatment options. previous studies have shown that decreased nutritional intake (less than 21 kcal/kg/day) is associated to a higher mortality compared to patients with a higher caloric intake. additionally, it has been suggested that subjects with severe ah, should receive a high-protein diet, however, no specific trials have been carried out to address these questions. thus, the investigators aim to compare nutritional interventions through a randomized controlled trial to assess if a strategy of peripheral parental nutrition (ppn) plus oral nutritional supplementation (ons) improves outcomes in patients with severe ah. the investigators will compare standard oral intake, enhanced oral intake with iv fluid supplementation, and ppn plus ons in patients admitted to hospital with severe ah. these results potentially will help guide practitioners on caloric benchmarks targets for patients with severe ah. this study will also assess specific risks and benefits of different nutritional interventions.


Eligibility criteria:
inclusion criteria: * adult (\>18 years) patients admitted with acute severe ah based clinical diagnosis according to niaaa criteria * excessive alcohol consumption for more than 5 years in a row or interrupted * no more than 60 days of abstinence before the onset of jaundice * bilirubin levels \>3 mg/dl (\>50 umol/l), ast\>50 iu/ml, ast/alt ratio \> 1.5 * abstinence of other causes of liver disease * meld score ≥ 20 exclusion criteria: * age \< 18 years * pregnancy or lactation. * allergy or intolerance to the enhanced oral intake formulation or ppn formulation. * expected length of stay less than 48 hours. * contraindications to iv fluid or ppn administration (fluid overload, suspected bacteremia). * presence of drug-induced liver injury (dili), ischemic hepatitis, biliary duct obstruction, viral hepatitis, autoimmune hepatitis, or wilson's disease. * extrahepatic neoplasia with a life expectancy of less than 6 months. * history of severe extrahepatic disease (e.g., chronic kidney failure requiring hemodialysis, severe heart disease (nyha class ≥3), severe chronic lung disease (class oro ≥3) that confers a survival of less than 6 months.
study of the impact of the covid-19 pandemic on the management of type 2 diabetic patients in a sample in the paris region

Conditions: COVID-19; Diabetes Mellitus, Type 2

Summary: the covid-19 crisis is undoubtedly the most significant event of the early 21st century. the pandemic has profoundly changed our way of life, whether as human beings, but also as patients or caregivers. this pandemic of an incredible magnitude, after having been minimized, blew a wind of fear on the whole world because of the unknown that the sars-cov2 virus represented. the world scientific community being destabilized, a great majority of states decided to apply a containment. in france, a strict containment was applied between march 17, 2020 and may 11, 2020 (1 month and 23 days, about 8 weeks). diabetic and obese patients were designated as "at risk" for infection by covid 19. type 2 diabetes is one of the most common chronic diseases in general practice. its regular management, we know, is largely related to lifestyle, which is particularly important in controlling the disease and preventing complications. during the first months of the pandemic, we witnessed many emergency room visits of patients with chronic pathologies, in full decompensation, due to a lack of follow-up but also due to a lack of treatment. after the first containment, in the endocrinology department of the paris saint-joseph hospital, we observed that many patients had a clear imbalance of their diabetes compared to their previous history. the main objective of this study is to show that the covid-19 pandemic, and more precisely the strict confinement applied in france from march 17, 2020 to may 11, 2020, had an impact on diabetes control in the study population. the secondary objectives are to study the explanatory covariates via the modification of the lifestyle of diabetic patients (decrease in physical activity, increase in poor dietary habits, psychological impact related to the situation, difficulties in accessing care, modification of work arrangements).


Eligibility criteria:
inclusion criteria: * patient whose age ≥ 18 years * patients with type 2 diabetes * patient consulting their attending physician for the follow-up of their diabetes or patient consulting the ghpsj diabetes service for the follow-up of their diabetes * patients who have an attending physician who follows their diabetes * patients living in the paris region * francophone patients * patients who do not object to the use of their data for this research exclusion criteria: * patient under guardianship or curatorship * patient deprived of liberty * patient under court protection
decreasing emergence delirium with personalized music

Conditions: Emergence Delirium

Summary: this is a prospective randomized controlled trial in children 3-9 years of age undergoing myringotomies at washington university in st. louis to assess the impact of perioperative personalized music on the incidence of emergence agitation.

aim 1: determine the efficacy of personalized music in decreasing the incidence of emergence agitation in pediatric patients undergoing myringotomies. patients undergoing myringotomy procedures will be randomized to receive either standard care or personalized music during the perioperative period. the incidence of emergence agitation will be determined using the pediatric anesthesia emergence delirium scale. aim 2: determine the efficacy of personalized music in reducing preoperative anxiety, postoperative pain, and maladaptive behavioral changes in pediatric patients following myringotomy procedures. anxiety will be assessed in the preoperative holding area using the modified yale preoperative anxiety scale and the induction compliance checklist (mask acceptance). postoperative pain will be assessed in the post-anesthesia care unit using the face, legs, activity, cry, consolability and wong-baker faces scales. behavioral changes will be measured using the post hospitalization behavior questionnaire via telephone calls on postoperative days 1 and 14 after discharge.

Eligibility criteria:
inclusion criteria: * child aged 3-9 years * presenting for unilateral or bilateral myringotomy under ga exclusion criteria: * combined procedures * lack of interest in music (e.g., child who does not have musical preferences) * inability to hear music (patients with mild-moderate hearing loss who can perceive music will be included) * parent/guardian or patient refusal

Keywords: anesthesia music pediatric anesthesia emergence delirium
optimisation of follicular recruitment in ivm cycles

Conditions: Infertility, Female; Polycystic Ovary Syndrome

Summary: the study will focus on important aspects related to follicle recruitment using exogenous gonadotropins in patients with polycystic ovaries: 1. early follicle recruitment in patients with polycystic ovaries using corifollitropin alfa: does administration of this drug result in earlier and higher fsh (follicle stimulating hormone) concentrations above the threshold for follicle recruitment in an ivm (in vitro maturation) cycle preceded by oral contraceptive suppression, in comparison to normal daily administration of rfsh (recombinant follicle stimulating hormone, puregon)?; 2. the maturation rate of the obtained oocyte-cumulus complexes in standard ivm media registered for clinical use: does stimulation with corifollitropin alfa versus recombinant fsh have an impact on the maturation rate and developmental capacity of the oocytes ?


Eligibility criteria:
inclusion criteria: 1. subfertile patients between 18-36 years old eligible for art treatment 2. bmi 18-30 3. polycystic ovaries (pco) according to the rotterdam criteria (at least 12 antral follicles per ovary as observed on a baseline ultrasound scan), with or without hyperandrogenism, with or without oligoamenorrhoea. in other words, patients are eligible if they have pco morphology. a diagnosis of pcos (polycystic ovary syndrome) based on rotterdam criteria is not compulsory. exclusion criteria: 1. antral follicle count (afc) \<24 2. anti-müllerian hormone (amh) \<3,25 in non-ocp (oral contraceptive pill) users and \<4,00 in current ocp users (using elecsys platform (roche diagnostics)) 3. couples requesting pgd (preimplantation genetic diagnosis) 4. non-obstructive azoospermia in the male partner
systemic adverse effects after osteopathic treatment and vitamin c

Conditions: Adverse Effects; Ascorbic Acid; Oxidative Stress

Summary: the goal of this triple-blind randomized clinical trial is to learn about systemic adverse effects in first visit patients who attend an osteopathic medicine center in barcelona. the main question it aims to answer are: • check if there is a relationship between taking vitamin c and the reduction in the appearance of systemic adverse effects after osteopathic treatment (24-72 hours) first-visit patients, at the end of treatment, are asked to enter the study. if they accept, they are administered 1g. of vitamin c, or 1g. placebo or nothing. if there is a comparison group: researchers will compare placebo group, control group and intervention group to see if there is a relationship between taking vitamin c and the appearance of systemic adverse effects\].

introduction systemic adverse effects (sae) after osteopathic treatment are rarely reported in the scientific literature. there is a consensus in the scientific literature that these adverse effects occur with a certain frequency, without it being clear what the pathophysiology of such effects is. the relationship between free radicals and central sensitization to pain is increasingly evident. vitamin c is known as a good electron receptor that is used by the body's antioxidant systems to reduce and also has anti-inflammatory properties. the brain has deficiencies in antioxidant systems and vitamin c has a very important role in the control of oxidative stress. objective check if there is a relationship between taking vitamin c and the reduction in the appearance of systemic adverse effects after osteopathic treatment (24-72 hours). design triple-blind randomized clinical trial, where one group was given 1g of vitamin c, another group was given 1g of placebo and the third group was given nothing. from april 1 to may 30, 2022, patients without food allergies or intolerances were recruited. the patients were randomly assigned to the study groups and neither the patient, nor the therapist, nor the person in charge of collecting the data was aware of which group each patient belonged to. adverse reactions were classified in relation to pain and fatigue. data collection was carried out through whatsapp messages to the patients 72 hours after receiving the treatment.

Eligibility criteria:
inclusion criteria: * first-visit patients * of legal age, * without food allergies or intelorenacies * the ability to receive and send messages via whatsapp. exclusion criteria: -

Keywords: osteopathic medicine manipulation, osteopathic adverse effects vitamine c ascorbic acid oxidative stress
pet perfusion imaging techniques and comparing them to ct perfusion imaging in stroke

Conditions: Acute Ischemic Stroke

Summary: adult patients who are diagnosed with an acute supratentorial ischemic stroke within 48 hrs of onset will be enrolled into the study. participants will undergo both a ct scan and pet scan within 7 days of onset. participants will have the option to undergo a second pet scan with fluorodeoxyglucose (fdg).

patients older than 18 years of age diagnosed with an acute supratentorial ischemic stroke within 48 hrs of symptom onset will be prospectively enrolled. research imaging will be obtained before 7 days after symptom onset. the patient will receive the standardized treatment protocol at the hospital. informed consent will be obtained from each patient or a substitute decision maker for each individual imaging study (ctp, rb pet, and fdg pet). the patient will be given the option of undergoing the ctp imaging with the rb pet only or both the rb pet and fdg pet components.

Eligibility criteria:
inclusion criteria: * age: \>18 yo * gender: male or female * acute (within 7 days from symptom onset) supratentorial ischemic stroke exclusion criteria: * 1) planned surgical intervention * 2) severely abnormal blood glucose level (will be excluded from fdg pet imaging) * 3) unable to undergo ctp or pet imaging (i.e. claustrophobia) * 4) pregnancy
botulinum toxin type a for treating allodynic pain in sci and ms

Conditions: Neuropathic Pain; Allodynia

Summary: this study will examine the efficacy of botulinum toxin type a ("botox") in treating allodynic-type neuropathic pain in people with spinal cord injury or multiple sclerosis. neuropathic pain is pain initiated or caused by injury to or disease of the nervous system, and is common in spinal cord injury patients or people with multiple sclerosis. allodynia is a type of neuropathic pain caused by something that normally would not cause pain, such as light touch, pressure from clothing, or bed sheets brushing against the skin. botox has been used to treat the muscle overactivity that causes spasticity in spinal cord injured patients. it has been noticed to exert some analgesic(pain relieving) effect, and has recently been studied as a treatment for neuropathic pain. we want to see if botox, injected intradermally, will relieve the symptoms of allodynic-type neuropathic pain. 24 volunteers are to be enrolled, with 16 receiving active treatment, and 8 "controls" receiving placebo.


Eligibility criteria:
inclusion criteria: * fulfills the criteria for neuropathic pain causing allodynia according to iasp pain terminology. * allodynia that is resistant to, or has failed, the standard level of care measures for more that six months. * allodynia pain on a daily basis. * allodynia pain that scores at least 4/10 on a pain numerical scale. * other pain medications(including antidepressants and anticonvulsants)have been maintained at a stable dose for at least 2 months prior to enrollment. * ability to communicate in english. exclusion criteria: * presence of other pain syndromes (e.g.,fibromyalgia, ongoing peripheral neuropathic pain. * allergy to botulinum toxin type a. * allergy to albumin. * use of botulinum toxin type a for other treatment indications in the 3 months prior to enrollment. * renal failure. * hepatic failure. * neuromuscular junction disorders. * bleeding diathesis. * cognitive impairment, dementia, major depression or psychotic disorder. * pregnant or breastfeeding. * infection at the injection site. * active alchohol or substance abuse.
post-marketing clinical study of postoperative adjuvant therapy with imatinib mesylate in patients with gastrointestinal stromal tumors (gist)

Conditions: Gastrointestinal Stromal Tumors

Summary: this is a multicenter, post-marketing, clinical study evaluating the safety and efficacy of postoperative adjuvant therapy with imatinib mesylate in high-risk patients after curative resection of newly diagnosed gist.patients will be evaluated for relapse -free survival as measured by the confirmation of tumor recurrence and survival for 3 years after surgery for their primary tumors.


Eligibility criteria:
inclusion criteria: * underwent macroscopically curative resection; * immunohistochemically confirmed kit (cd117)-positive tumors; * judged as being high-risk according to the criteria for risk classification exclusion criteria: * synchronous double cancer or metachronous double cancer with a disease-free period of ≤5 years; * received therapy with imatinib mesylate prior to study entry; * cardiac problem of grade 3 or higher (new york heart association (nyha) criteria) other protocol-defined inclusion / exclusion criteria may apply.

Keywords: gist imatinib postoperative adjuvant