Kornimate/medical-research-clean huggingface dataset:
study of the safety and effectiveness of hifu combined with regotori for metastatic colorectal cancer

Conditions: Colorectal Cancer

Summary: this study intends to perform high-intensity focused ultrasound combined with regotori in patients with multiline drug-resistant metastatic colorectal cancer to explore the safety and efficacy of patients. patients receive hifu local treatment combined with regotori treatment, and receive corresponding clinical data collection at different follow-up points, including necessary data from various laboratories, ct/mri, and immune function tests that are exactly the same as before surgery collection.


Eligibility criteria:
inclusion criteria: * the subject has metastatic colorectal cancer, and the first and second-line standard treatments have failed * there is at least one target lesion that can be treated with hifu * voluntarily accept this treatment clinical research, and sign the "subject informed consent" * 18-75 years old, no gender limit * the level of physical strength of the eastern cooperative oncology group (ecog): ps\<=2 * the expected survival time is greater than 3 months * no chemotherapy or radiotherapy within 21 days before enrollment * the function of major organs is basically normal exclusion criteria: * pregnant or lactating women * people infected with hiv, hepatitis c virus and treponema pallidum * there is an active infection that requires systemic treatment (such as active tuberculosis) * severe infection within 4 weeks before starting the study treatment * subjects who have received allogeneic tissue/solid organ transplantation * the patient suffers from major vascular disease or irregular bleeding disease * suffer from physiological or pathological malnutrition diseases, chronic diarrhea, cachexia, etc. * the patient has autoimmune diseases, such as (but not limited to) multiple sclerosis, systemic lupus erythematosus and inflammatory bowel disease, vitiligo * the patient has a history of serious drug or food allergy (for example, allergy to protein) * the patient has serious heart disease (including but not limited to: myocardial infarction, cardiomyopathy, valvular disease, malignant arrhythmia, etc.), severe liver and kidney damage, uncontrolled blood sugar and blood pressure (the subject's blood pressure, after using antihypertensive drugs, it still cannot be controlled within the normal range; fasting blood glucose is still \>10mmol/l after using antihypertensive drugs) * the patient has uncontrollable seizures or loss of insight due to mental illness * in the 12 months before screening, the patient has a history of drug abuse, drug abuse, and long-term alcoholism * within 3 months before screening, the patient is participating in other clinical studies * other situations that cannot participate in clinical research.
effect of d-cycloserine on treatment of posttraumatic stress disorder (ptsd) in youth

Conditions: Posttraumatic Stress Disorders; PTSD

Summary: the purpose of this study is to show whether d-cycloserine in combination with cognitive behavioral therapy (cbt) is more effective than cbt plus placebo to reduce symptoms of posttraumatic stress disorder (ptsd) in 7-12 year old children.

while most individuals with ptsd treated with cognitive behavioral therapy (cbt) show improvement, they still have some enduring symptoms and functional impairment. accordingly, there is a need for treatment advances. d-cycloserine (dcs), an antibiotic that has been used for over 50 years, has also been found to have positive effects on cognition and anxiety. dcs was found to enhance learning and memory, and also facilitates extinction of fear reactions. however, dcs only produces an extinction effect when paired with behavioral training, not when simply given alone. thus, the medication only needs to be given for seven doses in this research and youth do not need to take the medication long term. the research also includes a three-month follow-up assessment.

Eligibility criteria:
inclusion criteria: * certain number of ptsd symptoms plus functional impairment * must be able to swallow pills exclusion criteria: * serious kidney or liver disease * epilepsy * bipolar * psychosis

Keywords: cognitive behavior therapy children pharmacotherapy
breast cancer and quality of life

Conditions: Breast Cancer

Summary: the study aims to analyse and decode interviews of patient with breast cancer, and then established according a multidimensional profile specific to the population and to create a questionnaire tha will allow a practical and qualitative evaluation of the quality of life.


Eligibility criteria:
inclusion criteria: * age \< 45 * non metastatic breast cancer * at least 6 months of relationship exclusion criteria: * no life partner * inclusion criteria failure

Keywords: breast cancer everyday issues couple
circumferential submucosal incision endoscopic mucosal resection versus conventional endoscopic mucosal resection of colonic polyps

Conditions: Colonic Polyps

Summary: that circumferential submucosal incision endoscopic mucosal resection (csi-emr) will be at least as safe but more effective than conventional emr for injection assisted emr of large laterally spreading tumour and sessile polyps of the colon.

the investigators have recently developed a new, and the investigators believe safer and more effective technique for endoscopic mucosal resection (emr). utilising the new method the investigators make small cuts around the polyp to isolate it. subsequently the gelofusine solution is injected beneath the polyp and provides greater elevation. this allows us to improve the chance of removal of the entire polyp with one attempt in one piece. it is preferable to remove the polyp in one piece as it minimises the chance of leaving residual polyp tissue behind. our team has recently completed an animal study comparing our newly developed technique to conventional emr. the investigators have found significant improvements in our ability to completely remove the polyp in one attempt. there have also been recent studies overseas that have shown this new technique to be quite effective.

Eligibility criteria:
inclusion criteria: * can give informed consent to trial participation * age greater than 18 * adenomas that have not have previously been attempted for resection (i.e. naïve lesions) * adenoma size greater than 20 mm exclusion criteria: * age less than 18 * previous resection or attempted resection of target adenoma lesion * pregnant patients
effect of posterior pelvic tilt on balance and sensory integration in patients with non-specific low back pain

Conditions: Biochemical Lesions Lumbar Region; Orthopedic Disorder of Spine; Back Disorder

Summary: there is a debate in the literature about the effect of nslbp on pelvic tilt and its effect on balance, sensory integration and functional disability so we need this study to fill the aforementioned gap in literature in this field. so the purpose of the study is to evaluate posterior pelvic tilt effect on overall dynamic balance, sensory integration and functional disability in patients with non-specific low back pain.

the lbp became one of the biggest problems for public health systems in the world during the second half of the 20th century. the lifetime prevalence of lbp is reported to be as high as 84%, and the prevalence of chronic lbp is about 23%, with 11-12% of the population being disabled by lbp. prevalence of lbp was 53.2%. it was more among female patients (62.8%) than among male patients (38.3%) among attendants to a family health center in egypt. additionally, studies have observed relationships between chronic non-specific lbp and a posteriorly shifted center of gravity, impaired proprioception, and decreased muscular strength, activation and endurance of the trunk and hips. balance is impaired in individuals with chronic low back pain when compared to healthy individuals. most of these studies supposed that postural mal-alignment involves deviations in only one direction which is toward lordosis and anterior pelvic tilt. however, clinical experience suggests that some patients with back pain have the opposite problem which is a much reduced lordotic curve and a posterior pelvic tilt. if the true relationship between posture and low back pain disability is curvilinear instead, this could explain why the studies so far have shown weak or no relationships.

Eligibility criteria:
inclusion criteria: 1. fifty patients with chronic low back pain or repeated non-specific back pain for more than three months. 2. both sex with posterior pelvic tilt (-0.7 ± 6.5°)and decreased lumbar lordosis, for (group a) and normal anterior pelvic tilt angle between 5° and 13° for (group b) 3. their ages were ranged from 20-35 years. 4. body mass index from 18-25 kg/m² . exclusion criteria: 1. previous back surgery. 2. signs and symptoms of gross spinal instability. 3. radiological diagnosis of spondylolysis or spondylolisthesis. 4. acute low back pain. 5. disc prolapse or herniation. 6. any neurological, orthopedic, and vestibular disorders affecting the balance system. 7. flexion and extension restriction of the lumbar region. 8. other conditions that affected the normal functioning of the central and peripheral nervous system such as alcohol abuse, addiction, dementia, and cognitive disorders.

Keywords: pelvic tilt sensory integration balance back pain biodex
endothelial biomarkers of systemic sclerosis-associated pulmonary hypertension

Conditions: Scleroderma; Pulmonary Hypertension

Summary: systemic sclerosis (ssc, aka scleroderma) is an autoimmune condition characterized by endothelial damage and progressive fibrosis of the skin and internal organs. one of the leading causes of morbidity and mortality in patients with ssc is pulmonary hypertension (ph), which is estimated to occur in up to 31% of high risk ssc patients. early detection of patients with ssc-ph may lead to improved outcomes and although there have been concerted efforts to accurately screen for ssc-ph, these patients continue to present with advanced disease and suffer from poor survival. therefore, better methods to screen for patients with ph and, perhaps more importantly, to screen for those at risk for ph development are desperately needed. since ph and ssc are disorders originating from the endothelium, biomarkers that reflect endothelial damage are very promising tools to identify early disease. such potential biomarkers include endothelial microparticles, asymmetric dimethylarginine (adma), pentraxin-3, and soluble endoglin. no previous study has used a combination of these biomarkers to detect the presence of ph in patients with ssc, or studied the novel concept of exercise-induced changes in biomarker levels. the investigators will collect the above listed endothelial biomarkers before and after exercise, and combine these levels with exercise echocardiogram findings, and routine clinical information to derive a composite detection score for the early identification of systemic sclerosis-associated ph.


Eligibility criteria:
inclusion criteria: * 1. age \>18 years 2. meet american college of rheumatology criteria for ssc exclusion criteria: 1. chronic kidney disease (estimated creatinine clearance \<50ml/min) 2. uncontrolled hypertension (diastolic blood pressure\>120mmhg) 3. acute coronary syndrome within the past 6 months 4. chronic obstructive pulmonary disease 5. diabetes mellitus 6. hemolytic anemia 7. active tobacco abuse

Keywords: biomarkers endothelial microparticles
treatment of human cord blood mononuclear cell for delayed encephalopathy after carbon monoxide poisoning

Conditions: Delayed Encephalopathy After Carbon Monoxide Poisoning

Summary: the effects and safety of human cord blood mononuclear cell for delayed encephalopathy after carbon monoxide poisoning

to evaluate the effect and mechanism of human cord blood mononuclear cell transplantation for delayed encephalopathy after carbon monoxide poisoning

Eligibility criteria:
inclusion criteria: * 35-60 years old. * no serious infection, chronic diseases, diabetes and tuberculosis. * written informed consents were obtained from all subjects. * symptomatic delayed encephalopathy after carbon monoxide poisoning. exclusion criteria: * the heart, liver, kidney and other viscera serious organic disease. * allergic constitution, clotting disorders, autoimmune diseases and tumors. * pregnancy. * moribund patient. * history of prior brain injury. * history of central nervous system disease.

Keywords: carbon monoxide poisoning delayed encephalopathy
loxapine in the management of restlessness during mechanical ventilation weaning

Conditions: Restlessness

Summary: this study aims to assess the efficacy of a drug (loxapine, a neuroleptic) in calming patients down in a situation of restlessness during mechanical ventilation weaning. this drug is used for several years to quieten restless patients. its purpose is to restore spontaneous breathing sooner and therefore to reduce the risks of intubation and mechanical ventilation.

this study aims to assess the efficacy of a drug (loxapine, a neuroleptic) in calming patients down in a situation of restlessness during mechanical ventilation weaning. this drug is used for several years to quieten restless patients. its purpose is to restore spontaneous breathing sooner and therefore to reduce the risks of intubation and mechanical ventilation. 300 patients will participate in the study and will be randomized, after informed consent, to receive either loxapine or a placebo.patients whose proxies refuse participation will be sedated according to standard care procedures.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years, * sedated * under mechanical ventilation through intubation probe for more than 48 hours * no contra-indication to naso-gastric probe- with criteria for potential weaning * with social security * important restlessness at sedation withdrawal, defined as rass score (richmond agitation sedation scale)= 2. this restlessness has no potential danger for the patient but requires a level of sedation. this re-sedation implies administration of morphinomimetics and benzodiazepines at dosages that does not allow to pursue mechanical ventilation weaning attempts. exclusion criteria: * extreme restlessness at sedation withdrawal ((rass\>2) * allergy to loxapine or one of its component * dopaminergic agonists * extubation planned in the following 24 hours * antecedent of comitiality * known pregnancy at admission * proxies opposed to study participation

Keywords: restlessness during mechanical ventilation weaning
the sinonasal outcome test - 22, validated for danish patients

Conditions: Chronic Rhinosinusitis

Summary: introduction: chronic rhinosinusitis (crs) is a significant health problem increasing in both incidence and prevalence. it calls into attention consensus about diagnosing, assessing symptoms and treatment of patients with crs. therefore a validated danish measure of health-related quality of life in sinonasal disease is needed. method: the sinonasal outcome measure 22 (snot-22) was translated into danish and reproducibility was evaluated by test-retesting 40 patients with crs. the statistical analyses used, were pearson´s correlation coefficient, cronbach´s alfa, kappa and bland-altman´s plot. reproducibility was also tested looking at subscales within the snot-22. result: the results show good internal correlation with cronbach´s alfa at 0.83 in the initial test and 0.92 in the retest. pearson was 0.70 (p\<0.001) revealing good correlation between the initial scores and the retests scores. kappa was calculated for each item with a mean value of 0.61 showing substantial agreement. paired t-test revealed no significant difference in the subscales. conclusion: the danish version of snot-22 is recommended for danish clinicians and researches as a patient-reported measure of outcome in sino-nasal disorders such as rhinosinusitis and nasal polyposis.


Eligibility criteria:
inclusion criteria: persons diagnosed with chronic rhinosinusitis - exclusion criteria: change of treatment or acute change of symptoms due to common cold/influenza in the time between completing the test and the retest. if snot-score was very low. persons who left before offered test or declined testing. -

Keywords: chronic rhinosinusitis sinonasal outcome test 22
trial of the mend childhood obesity treatment program

Conditions: Obesity

Summary: the number of children who are obese in the uk is steadily increasing with both short and long term consequences for health. the aim of this study is to determine whether the mend programme (a new national initiative for the treatment of childhood obesity) is a successful and sustainable treatment for childhood obesity and obesity related health problems. 300 overweight and obese children will be randomly assigned to start immediately on the mend programme for 6 months or join a waiting-list control group for 6 months. measurements of health outcomes will be taken at baseline, and at 6, 12 and 24 months after the programme. after 6 months of waiting-list time, the control group will follow the same protocol as the immediate starters. the researchers will be unaware (blinded) to which group each child has been assigned to. the study will examine the effects of the mend programme on body composition, cardiovascular health and psychological health.

the study is a randomised controlled trial.

Eligibility criteria:
inclusion criteria: * children enrolled in the mend programme who are yet to be given a start date for the programme. * aged between 7-13 years old. * overweight or obese as defined by a bmi which falls above the 91st centile on the boys/girls bmi chart uk cross-sectional reference data:1997/1). * clinically well with no known chronic illness. exclusion criteria: * age less than 7 years or older than 13. * known chronic illness.
ketamine low dose evaluation on morphine consumption in traumatic patient

Conditions: Traumatic Injury

Summary: the aim of this study is to demonstrate a significant reduction of at least 25% in opioid consumption at 48 hours of management of severe trauma, while demonstrating non-inferiority in terms of analgesia, in a group of patients receiving a continuous infusion of low dose ketamine compared to a placebo group.


Eligibility criteria:
inclusion criteria: * male or female adult * trauma patient presenting at least 2 lesions in two different regions as defined by the iss (injury severity score) (head or neck, face, thorax, abdomen and pelvic contents, upper limbs or pelvic girdle, lower limbs, external (any skin surface). * patient presenting at least two regional disorders classified as moderate to maximum defined by an ais (abbreviated injury scale)\> 1. * patient having signed an informed consent exclusion criteria: * patients with an indication for deep sedation (intracranial hypertension or acute respiratory distress syndrome). * patient in whom the infusion could not be started within the first 6 hours of initial treatment. * patient whose state of consciousness is incompatible with understanding the protocol. * patient with chronic unbalanced arterial hypertension. * patient with severe heart failure. * patient with a bmi\> 35 kg / m² or a weight of more than 120 kg. * patient with chronic analgesic consumption defined by consumption of opioid derivatives for more than a week for an intercurrent illness. * presence of a history of chronic pain. * presence of a history of epilepsy. * presence of a history of psychosis or drug addiction. * presence of a history of stroke. * patients with an allergy to the molecule or excipients composing ketamine * patients with an allergy to the molecule or to the excipients making up sufentanil or paracetamol. * pregnant or breastfeeding woman. * patient not understanding french. * protected adult patient (under guardianship, curatorship or legal protection).

Keywords: ketamine analgesia iss trauma
expanded access protocol for patients with eosinophilic esophagitis

Conditions: Eosinophilic Esophagitis

Summary: this expanded access program is an open-label, single-arm design where consenting patients may participate up until apt-1011 is commercially available in the relevant regions or the protocol is terminated by the sponsor.

patients will receive a 120-day supply of apt-1011 and will attend scheduled clinic visits every 4 months. telephone visits will be performed as needed. at each clinic visit (or additional telephone visit), adverse events (aes) and concomitant medications will be collected. the global eoe score will be collected at clinic visits.

Eligibility criteria:
inclusion criteria: 1. male or female ≥12 years of age at the time of informed consent 2. signed icf and willing and able to adhere to all procedures; signed assent form and parent/guardian icf must also be collected for adolescents 3. confirmed medical history of eoe 4. adult and adolescent patients who are unable or ineligible to enroll in an apt-1011 clinical study or have failed available treatment options 5. willing and able to adhere to the treatment regimen and visit schedule exclusion criteria: 1. have known contraindication, hypersensitivity, or intolerance to corticosteroids 2. have signs and symptoms of adrenal suppression or hypercorticism 3. use of potent cyp3a4 inhibitors (e.g., ritonavir and ketoconazole) are prohibited 4. have current alcohol or drug abuse in the opinion of the investigator 5. female patients who are pregnant, breastfeeding, or planning to become pregnant while participating in the program 6. female patients of child-bearing potential who are unable to comply with adequate contraception use during the program

Keywords: apt-1011 esophagitis eosinophilic esophagitis esophageal diseases gastrointestinal diseases gastroenteritis eosinophilia leukocyte disorders hematologic diseases hypersensitivity, immediate hypersensitivity immune system diseases fluticasone anti-inflammatory agents bronchodilator agents autonomic agents peripheral nervous system agents anti-asthmatic agents respiratory system agents anti-allergic agents
correlation between sex and prognosis of acute aortic dissection in the chinese population

Conditions: Acute Aortic Dissection; Sex Role

Summary: the study evaluated the prevalence, presentation, management, and prognosis of coronary heart disease differ according to sex.

the study included 884 patients enrolled in our institute between june 2002 and may 2016. considering psychosocial factors, treatments, and the outcomes in men versus those in women with acute aortic dissection, explored the association of sex with psychosocial characteristics and mortality risk. of 884 patients, 211 (23.9%) were women. the median duration of follow-up was 2.9 years (25th -75th percentiles: 1-4 years ).

Eligibility criteria:
inclusion criteria: * acute aortic dissection exclusion criteria: * chronic aortic dissection

Keywords: aortic dissection sex treatment