Kornimate/medical-research-clean huggingface dataset:
freezing of gait in parkinson's disease

Conditions: Parkinson Disease

Summary: this study is designed to evaluate whether a specific visuospatial training task will change gait performance of parkinson's disease (pd) patients in doorways, specifically freezing of gait.

this study is a randomized, prospective, single-blinded six-week study in pd patients with freezing of gait (fog). this study will involve 2 study groups: group a - training group; group b - no training group/controls. both groups will complete a gait evaluation and neuropsychological testing. group a will also practice an in-home visuospatial task for 30 minutes, 4-6 days per week for six weeks. group b will not complete the in-home tasks. participation in this study is expected to last 6-8 weeks.

Eligibility criteria:
inclusion criteria: * age: greater than 18 years old and without an upper age limit * diagnosis of idiopathic pd exhibiting at least 2 or 3 cardinal signs (bradykinesia, rigidity, and resting tremor) * ambulate independently without an assistive device for at least 60 meters * freezing of gait episodes confirmed through the fog-q and evaluation by a fellowship trained movement disorder neurologist * willingness and ability to participate in training and complete training diary * documented fog-q and unified parkinson's disease rating scale (updrs) ii * ability to sign informed consent * pregnant females will be included in the study and there are no known risks to the pregnant female or fetus exclusion criteria: * inability to complete questionnaires * unwillingness to participate in training, complete all questionnaires and training diary * subjects with secondary causes of parkinsonism * significant dementia (moca \<20) * prior deep brain stimulation (dbs) surgery or pallidotomy * subjects cannot participate in any form of physical therapy, occupational therapy or speech therapy during the study period * subjects cannot start any new medications during the study period.
efficacy/safety/subject satisfaction/duration of response of clobetasol propionate spray vs ointment in plaque psoriasis

Conditions: Plaque Psoriasis

Summary: this study is a comparison between clobetasol propionate spray and clobetasol propionate ointment with regard to efficacy, safety, subject satisfaction and duration of response in moderate to severe stable plaque psoriasis. subjects will be enrolled and randomized into one of two groups: clobetasol propionate spray for 4 weeks of treatment or clobetasol propionate ointment for 2 weeks of treatment with a 2 week follow-up visit for each group.

same as above.

Eligibility criteria:
inclusion criteria: * subjects with a diagnosis of moderate to severe plaque psoriasis, defined as 3% - 20% of the body surface area. for the purposes of study treatment, most areas will be treated with the exception of face, scalp, groin, axillae and other intertriginous areas * overall disease severity is at least 3 (moderate) exclusion criteria: * subjects who have surface area involvement too large that would require more than 50 grams per week of clobetasol propionate spray or more than 50 grams per week of clobetasol propionate ointment * subjects whose psoriasis involves only the scalp, face or groin * subjects with non-plaque psoriasis or other related diseases not classified as plaque psoriasis
phenytoin as treatment for acute exacerbations of trigeminal neuralgia - a prospective systematic study of 20 patients

Conditions: Trigeminal Neuralgia

Summary: the nature of trigeminal neuralgia (tn) is fluctuating and patients can experience periods of complete remission of pain as well as periods with excessive pain. tn is often triggered by innocuous intra- and extraoral stimuli such as chewing. since the first-line prophylactic drugs, i.e. carbamazepine and oxcarbazepine, are administered orally, medical treatment of tn can be problematic in periods of exacerbation. in cases of severe exacerbation, patients oftentimes become dehydrated and anorectic as eating and drinking will evoke pain. treatment with drugs administered intravenously is needed in such situations. phenytoin was the first drug to be used for tn but it is rarely used as long-time preventative because of frequent side-effects associated with long-term use. however, phenytoin has the advantage over other drugs, that it can be administered also intravenously as fosphenytoin (the prodrug of phenytoin). by clinical experience the efficacy is very good. however, evidence of the treatment is lacking as only case reports including a total of 5 patients described the effects and side effects with pain relief lasting two days. by providing solid observational evidence, the treatment can be considered for incorporation in local and international treatment guidelines. the aim of the study is to test the hypothesis that fosphenytoin loading reduces tn pain with at least 50 % in 80% of patients with trigeminal neuralgia experiencing exacerbation of tn pain. the study is a descriptive prospective observational pilot study with 3 months followup period.


Eligibility criteria:
inclusion criteria: * age 18 years or older. * must be able to give signed informed consent prior to study entry. * must fulfill the ichd-3 diagnostic criteria for tn. both patients with purely paroxysmal tn and patients with tn with concomitant persistent facial pain will be included. * mri of the brain, brainstem and trigeminal nerve or patient is willing to undergo mri in the days and weeks following admission. * must be able to adhere to the study protocol and understand either danish or english. exclusion criteria: * psychiatric or mental illness or condition that might interfere with the ability of the patients to fill in the informed consent. * contraindications for phosphenytoin loading such as sick sinus syndrome, atrioventricular block and hepatic insufficiency.

Keywords: acute pain, fosphenytoin
pre-emptive infiltration of the scalp with diprospan plus ropivacaine for pain after craniotomy in children

Conditions: Pain; Postoperative Children

Summary: at present, pediatric postoperative analgesia has not been fully understood and controlled, particularly craniotomy surgery. on the one hand, professional evaluation of postoperative pain for young children is difficult; on the other hand, the particularity of craniotomy adds (such as consciousness obstacle, sleepiness, et al) disturbance to the pain assessment in children. although opioids administration is regarded as the first-line analgesic for post-craniotomy pain management, it may be associated with delayed awakening, respiratory depression, hypercarbia and it may interfere with the neurologic examination. for the avoidance of side-effects of systemic opioids, local anesthetics administered around the incision have been performed clinically. however, some studies revealed that the analgesic effect of local anesthetics was unsatisfactory due to its short pain relief duration, steroid as adjuvant can enhance postoperative analgesia and prolong postoperative analgesia time. as is reported that postoperative pain of craniotomy is mainly caused by skin incision and reflection of muscles, preventing the liberation of inflammatory mediators around the incision seems to be more effective than simply blocking nerve conduction. researchers have clarified that the addition of diprospan to local infiltration of analgesia could provide significant analgesic effects and significantly prolong the duration of analgesic effects without obvious complications for various types of surgeries. to date, no studies have evaluated the addition of diprospan to local infiltration for patients receiving craniotomy. thus, investigators suppose that pre-emptive scalp infiltration with steroid (diprospan) plus local anesthetic (ropivacaine) could relieve postoperative pain after craniotomy in children.


Eligibility criteria:
inclusion criteria: * an elective craniotomy under general anesthesia; american society of anesthesiologists (asa) physical status of i or ii; participates with an anticipated fully recovery within 2 hours postoperatively; informed consent by parent(s) and/or legal guardian. exclusion criteria: * history of allergies to any of the study drugs; drugs with confirmed or suspected sedative or analgesic effects; receiving any painkiller within 24 h before surgery; children who received steroids; psychiatric disorders; uncontrolled epilepsy; chronic headache; peri-incisional infection; body mass index exceeded the 99th percentile for age; children who must use a patient-controlled analgesia (pca) device; children who cannot understand an instruction of pain scales before surgery
effects of physical therapy on the multisystems of children with cerebral palsy: a longitudinal study

Conditions: Cerebral Palsy; Physical Therapy Modalities

Summary: cerebral palsy (cp) refers to childhood movement and posture disorders, whose severity, patterns of motor involvement and associated impairments are very varied. it is the most prevalent type of physical disability in children. any non-progressive central nervous system (cns) lesion that occurs in the prenatal, perinatal and postnatal period up to 2 years of life is considered cp. thus, the present work aims to evaluate, monitor and verify the effects of physical therapy interventions on gross motor function, spasticity, balance, muscle activation, fatigue, respiratory system, functionality and social participation in children with cerebral palsy. this work will use some evaluation scales such as the gross motor function measure (gmfm-66), the modified ashworth scale (mas), the early clinical assessment of balance (ecab), electromyography, the fatigue severity scale and the pediatric functional status. scale. in addition to questionnaires, which will be applied directly to parents/caregivers, such as the young children's participation and environment measure (yc-pem), the pedi (pediatric evaluation disability inventory) and the goal attainment scaling (gas).


Eligibility criteria:
inclusion criteria: * clinical diagnosis of cerebral palsy * aged between 0-12 years * classified in all the levels of the gmfcs * those responsible agree to release the minor to participate in the study and sign the free and informed consent form (fict) exclusion criteria: * have had botulinum toxin applied 6 months before the intervention * recent surgery * other physical abnormalities, genetic or severe syndromes.

Keywords: cerebral palsy physical therapy modalities longitudinal studies disabled children
management of perioperative pain using erector spinae plane block in open microscopic lumbar surgery

Conditions: Lumbar Spine Disease

Summary: the aim of this study is to compare patients receiving bilateral erector spinae block with ropivacaine vs control group in terms of pain score, total opioid consumption, hemodynamic changes intraoperatively, length of hospitalisation , time to ambulation post surgery and quality of recovery.

most open spine surgery exacts a high degree of postsurgical pain due to the incision and muscle dissection of the vertebra. the postoperative pain control and early mobilization improve the quality of the surgical care. inadequate pain relief might result in perioperative morbidity, resulting in prolonged hospital stays. erector spinae plane block (espb) is an interfascial plane block where local anaesthetic is injected in a plane preferably below the erector spinae muscle. it can provide thoracic, abdominal, and even some lower extremity analgesia. it was also theorised that erector spinae plane block can reduce opioid use and provide analgesia for lumbar surgery. the financial cost that is saved by reducing the length of hospital stay, perioperative morbidity will warrant the use of erector spinae plane block in patients undergoing lumbar spine surgery.

Eligibility criteria:
inclusion criteria: * age 18-75 * patients with glasgow coma scale of 15. * american society of anaesthesiologists (asa) physical status classification i - ii patients * scheduled for elective, open microscopic lumbar surgery (less than 3 levels) under general anesthesia. exclusion criteria: * cognitive impairment * patient refusal * weight\ 120kg * allergy to local anesthesia * alcohol/ drug abuse * renal failure or liver failure * coagulopathy/thrombocytopenia * chronic pain with chronic opioid usage * ischemic heart disease
evaluation of the clinical relationship between procalcitonin level and bacteremia agent in intensive care unit patients

Conditions: Sepsis; Septic; Bacteremia and Sepsis; Intensive Care Medicine; Procalcitonin

Summary: in intensive care units, sepsis, which can be defined as bacteremia and the irregular and uncontrolled inflammatory response to it, is one of the most important causes of mortality. early recognition of sepsis and appropriate antibiotic use for the causative agent is one of the most important steps in the fight against sepsis. procalcitonin (pct) is a calcitonin precursor peptide and has been reported to predict bacteremia early. while the pct concentration level is negligible in healthy individuals, it has been shown to increase especially in bacterial infections, sepsis, trauma and burns. in our study, our aim is to determine whether there is a relationship between serum pct concentration levels taken within 24 hours according to the time of the sample taken for blood culture with growth in patients followed up in our internal intensive care unit.


Eligibility criteria:
inclusion criteria: * positive blood culture during their follow up * patients over 18 years of age exclusion criteria: * those under the age of 18 * those who have had surgery or trauma in the last 72 hours * those with a history of autoimmune disease, chronic renal failure * patients admitted to intensive care due to acute pancreatitis, pregnancy, burns. * patients with incomplete data.

Keywords: procalcitonin sepsis septic shock intrensive care medicine
influence of the 3d-sonographic representation of the fetal face on the health-conscious behavior of pregnant women

Conditions: Behavior

Summary: studies have shown that ultrasound examinations during pregnancy have a short-term anxiety and stress-reducing effect, without having any influence on the mother-child bond or health-conscious behavior. it has not yet been investigated to what extent the representation of the child's face alone achieves a lasting positive effect if the representation in 3d form were permanently available.


Eligibility criteria:
inclusion criteria: * pregnant women undergoing ultrasound exclusion criteria: * age \<18 years
multiple dose effect of oxytocin on males with high or low trait anxiety

Conditions: Healthy

Summary: to examine whether multiple doses of oxytocin have different effects on behavior and neural indices in males with high or low trait anxiety.

in the present study, healthy male subjects' trait anxiety levels will be assessed by the sub-trait inventory of the state-trait anxiety inventory (stai). according to subjects' trait anxiety scores, they will be divided into high or low anxiety experimental groups. next, experiments will investigate the acute effect (single dose) and chronic effect (3 doses or 5 doses) of oxytocin on brain functional connectivity during resting-state and brain activation in response to watching emotional stimuli using functional magnetic resonance imaging (fmri). also the brain structure data (t1 and diffusion tensor imaging, dti) of subjects will be collected. after finishing the scanning tasks, subjects will be required to rate the emotional valence, intensity and arousal of the pictures shown in the scanner. during the course of the study subjects will complete a number of questionnaires: empathy quotient (eq), cheek and buss shyness scale (cbss),interpersonal reactivity index (iri),childhood trauma questionnaire (ctq),beck depression inventory (bdi), state-trait anxiety inventory (stai), autism spectrum quotient (asq), liebowitz social anxiety scale (lsas),positive and negative affect schedule (panas),d2 attention test, and the visual analogue scale for anxiety.

Eligibility criteria:
inclusion: * healthy adult males exclusion: * past or current psychiatric or neurological disorder * head trauma * substance abuse * medication * fmri contraindications (e.g. metal implants)

Keywords: multiple doses oxytocin trait anxiety
tvt-secur a pilot study for the treatment of stress urinary incontinence

Conditions: Stress Urinary Incontinence

Summary: the primary objective of this study is to obtain clinical performance information on the gynecare tvt-secur\* system (tension-free support for incontinence) in women with stress urinary incontinence (sui).

the primary variable for effectiveness is \> 50% improvement on the subjective symptom visual analog scale (vas) at visit 3/week 5 (35 days post-surgery) to be accepted.

Eligibility criteria:
inclusion criteria: * must be female with objective, demonstratable signs of sui or stress predominant mixed incontinence and requires elective, primary surgical intervention. * must be at least 21 years old. * must be postmenopausal (amenorrhea) for at least 1 year or surgically sterile (bilateral salpingo-oophorectomy or tubal ligation or otherwise be incapable of pregnancy) or has a negative pregnancy test prior to study entry and has decided to cease childbearing. * agrees to participate in the study, including all study related procedures and evaluations and documents this agreement by signing the irb/ec-approved informed consent exclusion criteria: * have any other coexistent pathology requiring concomitant surgery that may impact this procedure i.e. surgeries that involve the anterior vaginal wall (e.g. anterior colporrhaphy, diverticula, anterior prolift) any allowable concomitant surgery must be performed prior to the gynecare tvt secur system surgery. * have intrinsic sphincter deficiency (isd) \[urethral pressure profile (upp) with a maximum urethral closing pressure (mucp) \< 20cm h2o or leak point pressure (lpp) \< 60\]. * have an active urinary tract infection (uti) or vaginal infection at time of surgery. * have a fixed urethra (\< 30° mobility on q-tip straining test). * have had prior incontinence surgery. * have a post-void residual volume \> 100ml. * have co-existent pelvic organ prolapse that is symptomatic or extends beyond the hymen. * have lower urinary tract pathology in the form of a fistula or diverticulum. * have a malignancy or with a history of malignancy within the past 5 years, except for a basal cell carcinoma that has been treated with local excision and is no longer present. * are on anticoagulant therapy. * have received an experimental drug or used an experimental medical device within 30 days prior to the planned start of treatment. * are deemed by the investigator as medically unfit for surgery or who in the opinion of the investigator should not be enrolled in the study because of the precautions, warnings or contraindications outlined in the gynecare tvt secur system ifu. * employees of the investigator or study center with direct involvement in the proposed study or other studies under the direction of that investigator or study center.

Keywords: incontinence stress urinary
objective markers of pain perception in pediatric emergency

Conditions: Suffering, Physical

Summary: pain is a major problem in the care of children in pediatric emergencies. indeed, its relief rests on the oral communication of the young patient, who does not always able to it (difficult to verbalize, fear of the hospital, problem mental development ...). there is no way in which pain can be apprehended objectively, immediately and effectively. to advance our knowledge of this problem, several approaches have been studied as from functional magnetic resonance imaging (fmri), electroencephalography (eeg), or from autonomic parameters. however, all these approaches have their limitations: although fmri presents interesting performances, it allows only a retrospective analysis, and cannot adapt to the clinical context of the young patient for example. eeg-based approaches and autonomic parameters show interesting results but suffer from perfectible sensitivity to muscle activation for eeg whereas the vegetative parameters to stress. in this context, our working hypothesis considers that the search for markers of painful perception must be based on a neurophysiological approach, based on the combined analysis of the eeg and autonomic responses in real time. the aim of this work is to study (1) the cortical (eeg) and autonomic (cardiovascular, skin, pupillary) responses induced by sutures in children who can communicate their pain according to whether they cause pain or not.


Eligibility criteria:
inclusion criteria: * requiring one or more non-complex sutures in department of pediatric emergency * affiliate or beneficiary of social security (parents) * signature of consent (parents) exclusion criteria: * historic of cardiovascular diseases (arterial hypertension, etc), renal or metabolic syndrome (diabetes etc.), psychiatric (depression, etc.) or neurological (epilepsy seizure, etc.) * trouble of heart rhythm * allergy at conductive gel for electrode * sutures requiring a general anesthesia * contraindication at the xylocaine and/or paracetamol

Keywords: pain children emergency electroencephalography heart rate skin conductance pupillary diameter
dosing of thromboprophylaxis and mortality in critically ill covid-19 patients

Conditions: Covid19; Thromboembolism

Summary: the aim of the study is to associate dose of thromboprophylaxis with outcome in critically ill covid-19 patients. this will be done by associating dose of thromboprophylaxis with 28-day mortality, survival outside icu, thromboembolic event and bleeding complications.this was done in our earlier study for patients admitted in march and april (clinicaltrials.gov nct04412304 june 2 2020) but now we will include the patients admitted in may, june and half of july and we will ad the outcome of 90-day mortality.


Eligibility criteria:
inclusion criteria: * laboratory confirmed positive test for sars-cov-2 * admitted to icu because of respiratory failure caused by covid-19 exclusion criteria: * patients with treatment for thromboembolic complications at arrival to the icu * short icu length of stay defined as discharged the same date as icu admission * patients without initial thromboprophylaxis

Keywords: pulmonary embolism anticoagulation critical care bleeding ischemic stroke
epispot detection of circulating prostate cells among adenocarcinoma patients

Conditions: Adenocarcinoma of the Prostate

Summary: the primary objective of this study is to evaluate the predictive value (in terms of remission) of a new technique for detecting circulating, functional, prostate cells among patients with localized adenocarcinoma of the prostate, and prior to any treatment.


Eligibility criteria:
inclusion criteria: * the patient must have given his/her informed and signed consent * the patient must be insured or beneficiary of a health insurance plan * histologically proven presence of prostate adenocarcinoma * localized disease on digital rectal examination * cancer without extensions * acceptance of a curative treatment by the patient exclusion criteria: * the patient is participating in another study * the patient is in an exclusion period determined by a previous study * the patient is under judicial protection, under tutorship or curatorship * the patient refuses to sign the consent * it is impossible to correctly inform the patient * the patient is taking a hormone-modifying treatment * patient taking adrogenic supplements