Kornimate/medical-research-clean huggingface dataset:
extremely low frequency magnetic fields in acute ischemic stroke

Conditions: Stroke

Summary: there is great interest in the development of novel therapies for acute ischemic stroke because, to date, the thrombolysis is the only approved treatment. recent evidence suggests that extremely low frequency magnetic fields (elf-mf) could be an alternative approach for acute ischemic stroke therapy because of their effects on the main mechanisms of brain ischemic damage and regeneration.the main purpose of this open label, one arm, dose escalation study is the validation of elf-mf stimulation as non-invasive, safe and effective tool to promote recovery in acute ischemic stroke patients nine patients will be treated daily for 5 consecutive days, starting within 48 h from the onset of stroke. three dose cohorts of three patients each, will be stimulated with pulsed elf-mf (75 hz, 1,8 mt) at increasing daily exposure (45, 120, 240 min).the primary outcome (safety endpoint) will be evaluated by the incidence of adverse events and mortality throughout the stimulation period and the 1-year follow-up. secondary outcomes will consist in change from baseline in clinical and radiological scores.


Eligibility criteria:
inclusion criteria: * males or females, aged over 18 * evidence of mono-hemispheric ischemic stroke confirmed by brain mri * first onset stroke patients * onset of symptoms within 48 hours prior to enrollment * national institutes of health stroke scale (nihss) score greater than 4 * patient is alert, medically stable according to the treating physician and able to follow simple verbal commands * signed written informed consent prior to entry into the study exclusion criteria: * acute intracranial hemorrhage confirmed by brain ct or mri scan * previous ischemic or hemorrhagic stroke * seizure at the onset of stroke or a history of epilepsy * contraindications to transcranial magnetic stimulation: implanted metallic parts of implanted electronic devices, including pacemakers,defibrillators, implanted medication pump, or implanted brain stimulator * aneurysm clip or other metal in body * life expectancy less than 3 months * other serious illness, e.g., severe hepatic, cardiac, or renal failure, acute myocardial infarction, or complex disease that may confound treatment assessment * women known to be pregnant, lactating or having a positive or indeterminate pregnancy test * any condition that would prevent the subject from giving voluntary informed consent * current participation in another study with an investigational drug or device

Keywords: acute stroke brain ischemia extremely low frequency magnetic fields
physiological response of cortisol to cardiac catheterization

Conditions: Adrenal Insufficiency

Summary: cortisol is essential for survival. the importance of cortisol response is most apparent in patients with partial or complete deficiency of glucocorticoids during stressful events such as illness or surgery.

it is known that cortisol and other stress hormones increase during acute myocardial infarction as well (9-11). cardiac catheterization is an essential tool for the management of acute coronary syndrome, and for the evaluation of the burden of coronary artery disease in cardiac patients.

Eligibility criteria:
inclusion criteria: * patients undergoing elective cardiac catheterization, who are willing and able to give consent. exclusion criteria: * • patients with .primary or secondary adrenal insufficiency. * patients taking steroids in the doses equivalent of at least 5 mg of prednisone daily for more than 3 weeks in the previous year. * patients undergoing cardiac catheterization in the setting of acute coronary syndrome, eg. stemi, nstemi and unstable angina. * patients with low albumin level (\<3.5 g/dl)

Keywords: adrenal steroids cortisol stress
the efficacy of music on perioperative pain management

Conditions: Perioperative Pain Management

Summary: the goal of this clinical trial is to learn if intraoperative music stimulation works to alleviate perioperative pain in surgical patients undergoing general anesthesia. it will also learn about the possible mechanisms by how music affects pain. the main questions it aims to answer are: does music lower the number of times participants need to use a rescue analgesic? what changes occur in electroencephalogram (eeg) and nociception monitors when participants listen to music? researchers will compare music to mute or control (hear ambient sounds without earphones) to see if music works to alleviate perioperative pain. participants will listen music or mute or ambient sounds throughout the operation, and receive routine anesthesia care.


Eligibility criteria:
inclusion criteria: * older than 20 years old and younger than 80 years old * male or female * scheduled for minimally invasive surgery (laparoscopic cholecystectomy, appendectomy) * ambulatory surgery * american society of anesthesiologists (asa) physical status i\~iii exclusion criteria: * severe hearing impairment * severe pulmonary or cardiovascular disease * brain or central nervous system (cns) disorder * long-term systemic steroid or daily morphine treatment * pregnant women * emergency surgery * the absence of informed consent

Keywords: music therapy
tzanck smear with methylene blue stain for herpes

Conditions: Herpes Simplex; Herpes Zoster; Varicella Zoster

Summary: to compare the sensitivity of tzanck smear with methylene blue stain versus traditional giemsa stain in patients with herpes infection.

a smear from the lesional skin of the patients suspected having herpes simplex, herpes zoster and varicella zoster skin infections will be collected (in a clinical routine setting). the specimen will be stained with methylene blue in addition to the giemsa stain. polymerase chain reaction study for herpes antigen will be performed in some of the specimens. the sensitivity, specificity, positive predictive value and negative predictive value will be calculated from the results of the study.

Eligibility criteria:
inclusion criteria: * patients with clinically suspected of having herpes simplex, herpes zoster, varicella zoster skin infections. * those who have vesicular skin lesion such as acute eczema, paederus dermatitis. * those are well cooperative. * age \> 18 years old. exclusion criteria: * those who are not willing to have specimen from skin lesions to be collected.

Keywords: methylene blue giemsa tzanck smear
sp resistance and falciparum malaria transmission

Conditions: Plasmodium Falciparum Malaria

Summary: the purpose of this study is to study resistance to current malaria treatments and affordable alternatives for uncomplicated malaria. resistance occurs in areas where these treatments are used frequently. this study may help prevent future resistance. about 150 residents in buenaventura, colombia will participate. they will have uncomplicated malaria and they will be followed for 28 days after treatment. physical exams and blood draws are included in study visits.

drug-resistant plasmodium falciparum is a major threat to global public health and new strategies are needed to deter spread of resistance to available and forthcoming antimalarial drugs. this study seeks to contribute to understanding the molecular basis of spread of drug resistance in a setting with low level of sulfadoxine-pyrimethamine (sp) treatment failure. the objectives of this study are to compare the prevalence of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) point mutations associated with sp resistance before and after sp treatment of uncomplicated plasmodium falciparum malaria episodes and to measure parasite infectivity to anopheles mosquitoes of post-treatment gametocytes with and without dhfr and dhpr mutations. patients with uncomplicated falciparum malaria will receive a standard sp regimen and will be closely followed for 28 days. this study will add new knowledge of the understanding of ways in which resistance is spread and is expected to provide a sound basis for the future clinical evaluation of antimalarial drug combinations designed to prevent transmission of drug-resistance malaria.

Eligibility criteria:
inclusion criteria: age more than 5 years positive blood smear for falciparum malaria informed consent from participant or parent intention to remain in the study area for at least 4 weeks from the time of enrollment exclusion criteria: mixed plasmodium infection parasitemia \> 10% hematocrit \< 15% respiratory distress spontaneous bleeding (from gums, nose, gastrointestinal tract, etc.) recent seizures or coma prostration or weakness, so that the patient cannot sit or walk, with no obvious neurological explanation inability to drink persistent vomiting history of allergy or adverse reaction to sulfadoxine-pyrimethamine (sp) or sulfa drugs known pregnancy

Keywords: malaria, plasmodium falciparum, drug resistance, colombia
influence of the restorative cervical margin placement on the supracrestal tissue attachment

Conditions: Gingivitis

Summary: the aim of the present study is to understand the influence that marginal/subgingival restorations exert on the surrounding periodontal tissues. even though proximal restorations are routine in everyday clinical practice, few information is available as to whether or not they may have a detrimental effect on the supracrestal tissue attachment.


Eligibility criteria:
inclusion criteria: * an age range 18-70 years * a good general health * the ability to understand the phases of the trial and to stick to them for the whole length of the study * the ability of will to release a written informed consent * presence of a marginal cavity or a 2mm subgingival cavity * presence of a cavity subgingival \> 2mm exclusion criteria: * ppd\>4mm * patients affected by active periodontal disease * patients smoking more than 10 cigarettes/pipes per day

Keywords: subgingival restorations proximal restorations cytokine biomarkers gcf sampling
efficacy biomarker investigation on extensive stage small cell lung cancer

Conditions: Extensive Stage Small Cell Lung Cancer

Summary: the purpose of the trial is to find some biomarkers to predict the efficacy of atezolizumab plus etoposide and platinum based chemotherapy as the first line treatment in extensive stage small cell lung cancer. mainly observe the patient's progression free survival time after treatment.


Eligibility criteria:
inclusion criteria: * 18， extensive stage small cell lung cancer confirmed by histopathology treated with atezolizumab plus etoposide and platinum based chemotherapy exclusion criteria: - patients with contraindication of chemotherapy pregnant or breast feeding women
comparative evaluation of shade matching using a digital spectrophotometer in monochromatic versus polychromatic layering techniques for restoring fractured incisal angles of maxillary incisors - invivo study

Conditions: Class IV Dental Caries

Summary: the color and appearance of a tooth is complex phenomenon which is related to many factors such as color stability, the blending effect, color induction, color assimilation effect of resin composite materials which are all fall under the term chameleon effect which enables resin composite material to obtain a shade that bears a resemblance to the color of the surrounding tooth structure. the usage of different opacities and shades to match the tooth structure is very time consuming for both patient and clinician. however, any clinical effectiveness of any dental restorative procedures such as composite replacement is dependent on their physical, chemical and mechanical features which are highly proportional with oral environment and resin material properties.

resin composite material allow light scattering between enamel and dentin which aid in internal diffusion so that resin composite material blend with the surroundings. the color alteration also is directly proportional with light absorption to make it undetectable when blended with tooth structure a significant disadvantage of resin composite restorations is highly susceptibility to staining and discoloration by the time and aging process in the oral environment. color instability is one of the main reasons for replacing restorations, particularly in anterior teeth. there are several factors that affect the color stability of resin composite including intrinsic factors, namely the chemical make-up of the materials. moreover, other extrinsic factors including smoking and poor oral hygiene, as well as the absorption of dyes from consuming foods and beverages in the oral cavity influence the color stability of resin composite restoration. the color of any observed restoration is dedicated by light scattering between resin composite material and other substrates such as tooth structure beneath restoration and other hard dental tissues. natural teeth and resin composite material should share three basic parameters chroma , hue and value . other parameters effect on observation such as opacity, translucency, glossy surface should be put in consideration during resin based composite manufacturing. this investigation sought to determine the effectiveness of three distinct approaches to shade matching when restoring class iv in dental maxillary incisors using universal universal shade dental composite technique, traditional polychromatic layering dental composite technique, and contemporary monochromatic single shade dental composite technique.

Eligibility criteria:
inclusion criteria: * fractured incisal angles in vital maxillary permanent incisors * aged 16 to 35 * exhibits good oral hygiene exclusion criteria: * individuals with nonvital or endodontically treated teeth * active periodontal disease * significant medical complications * malocclusion * parafunctional habits
a survey of breast cancer patients with metastatic bone disease receiving oral ibandronate

Conditions: Metastatic Breast Cancer

Summary: this observational, multicenter survey is designed to assess the efficacy of oral ibandronate in adults with breast cancer and metastatic bone disease. data on the use of ibandronate in clinical practice will be collected from hungarian patients.


Eligibility criteria:
inclusion criteria: * adults at least 18 years of age * histologically confirmed breast cancer with bone metastasis * receiving or indicated for the tablet formulation of ibandronate according to the summary of product characteristics (smpc) and local labeling exclusion criteria: * contraindication to ibandronate according to smpc * ongoing participation in any trial evaluating the efficacy and/or safety of ibandronate
effects of progressive resistance training on physical state energy and fatigue during pregnancy.

Conditions: Pregnancy Related

Summary: the purpose of this study is to compare the effects of progressive resistance training on physical state energy and fatigue during pregnancy. this study was a randomized controlled trial used to find the effects of progressive resistance training on physical state energy and fatigue during pregnancy. the data was collected from sheikh zaid hospital via visual analogue scale-fatigue, numeric pain rating scale and short form health survey-36. sample size of 30 females was taken in 15 each group.

according to the findings of a study on physical activity during pregnancy in 2021, obese women, who exercise less than ladies of normal body weight may gain from gradually increasing their amount of exercise to reduce the amount of weight gain associated with pregnancy. exercise during pregnancy was consistently associated positively with sob-r among the women in both categories, which denotes that it may have an impact on the control of lepton activity and pregnancy-induced insulin resistance. overall, our research suggests that obese women, who are lepton-resistant and at pregnant women at high risk of gestational diabetes, fast weight gain, and increased fetal adiposity should receive advice and supportive services to raise their activity level, with an emphasis on the fact that even slight improvements in action can be good for both child and maternal health.

Eligibility criteria:
inclusion criteria: * female with age of 20 to 40 years * between 20-25 weeks of gestation. * healthy individual * pregnant females who are easily fatigued during activities of daily living. exclusion criteria: * • those who reported regular resistance training exercises * complicated pregnancy * low pre-pregnancy body weight * anemia * diabetes * psychiatric disorder * orthopedic and cardiovascular limitation

Keywords: energy state fatigue pregnancy muscle stretching exercises
evaluation of prognosis with integrated mri/pet in patients with pancreatic cancer

Conditions: Pancreatic Cancer

Summary: the aim of this study was to evaluate mr/pet with both functional and molecular imaging on the prediction of prognosis in patients with suspected pancreatic cancer.

the results of mr/pet will be compared prospectively to dedicated mdct or mr imaging, pathologic results, and clinical outcomes to assess the value of mr/pet in pancreatic cancers.

Eligibility criteria:
inclusion criteria: 1. diagnosed as pancreatic cancer 2. between 20\~90 years old 3. ecog 0-2 4. normal renal function 5. measurable tumor size (\>1cm) exclusion criteria: 1. contraindication for mri exam 2. claustrophobia 3. renal insufficiency 4. other malignancy 5. pregnancy and lactating women

Keywords: mr/pet pancreatic cancer
retrospective data analysis of patients treated for macular edema due to central retinal vein occlusion

Conditions: Retinal Vein Occlusion

Summary: the objective of this retrospective chart review is to evaluate drug utilization, usage patterns and indication of effectiveness eylea in the routine clinical (real-life) management of patients who suffer from me (macular edema), secondary to crvo (central retinal vein occlusion), and who started treatment with eylea for this indication.


Eligibility criteria:
inclusion criteria: * male or female adult patients who suffer from visual impairment due to me secondary to crvo * anti-vegf treatment-naive patients who started reimbursed eylea treatment between the 1st of june 2014 and the 28th of february 2015 exclusion criteria: * patients diagnosed with neovascular glaucoma secondary to crvo will be excluded.
cost effectiveness of the endophys pressure sensing access system vs. radial a-line for intra-operative blood pressure monitoring

Conditions: Cerebrovascular Disorders

Summary: this study aims to compare the time difference between radial arterial line placement and use of the endophys sheath, as well as, assess the cost effectiveness of the enophys sheath vs. use of a radial arterial line based on device and operating room costs.


Eligibility criteria:
inclusion criteria: * all elective neuro endovascular procedures requiring general anesthesia and continuous invasive blood pressure monitoring * adequate access to both the radial or femoral artery exclusion criteria: * pre-operative identification of contra-indication for radial arterial line placement * hemodynamic instability * need for continued post-operative invasive blood pressure monitoring * failure to obtain informed consent
simulated in-house usability study of eclipse continuous positive airway pressure (cpap) device

Conditions: Obstructive Sleep Apnea

Summary: the study is designed to assess the usability of a novel cpap human interface compared to a traditional nasal mask. human subjects will interact with two different cpap interfaces including a traditional cpap mask and the 2nd generation dreamport-eclipse. subjects will be requested to put on each of the different cpap interface options a total of three times for a total of 6 trials. the order of device will be randomized.


Eligibility criteria:
inclusion criteria: * male or female ≥18 years old who are impacted by obstructive sleep apnea and currently are familiar with a cpap device. exclusion criteria: * diagnosis of any medical or behavioral conditions that would compromise subject safety. * under the age of 18: target for this current version of the platform is the adult population.
identification of microbiome and metabolome of bronchiectasis in chinese population.

Conditions: Bronchiectasis

Summary: this study aims to investigate the characteristics of gut microbiome and metabolome in non-cf bronchiectasis patients, hoping to explore the underlying mechanisms as well as the influence of gut microbiota composition on bronchiectasis.

non-cystic fibrosis bronchiectasis is a chronic airway disease characterized by irreversible and progressive dilation of the large airways, bronchi and bronchioles, which severely impairs the life quality of patients and increases the social and economic burden. it is also a heterogenous disease affected by multiple factors such as geography and ethnicity. the incidence of bronchiectasis among the chinese population is about 1.2%, which has clearly been underestimated. however, due to the lack of awareness, the research of bronchiectasis in china is still in its infancy. colonization and recurrent infection of pathogen is the primary unsolved problem in clinical practice. with the proposition of "gut-lung axis" theory, the role of gut microbiota in the pathogenesis of respiratory diseases has been gradually revealed. evidences have shown that gut microbiota regulates respiratory immunity via releasing soluble bacterial components and its metabolites into the circulation, as well as facilitating the migration of immune cells directly to the lung. in the 1980s, a patient after a colectomy has been reported to generate bronchiectasis. the most common clinical manifestation of pulmonary involved ibd patients is also bronchiectasis, suggesting that the "gut-lung axis" may be involved in the pathogenesis of bronchiectasis. therefore, clarifying the role and mechanism of gut microbiota in bronchiectasis and its gut microbiome is expected to provide new theoretical basis and ideas for its diagnosis and treatment.

Eligibility criteria:
inclusion criteria: * written informed consent * regular bowel movement: every 2 days - 3 times/ day * the diagnose of bronchiectasis should refer to "bts guideline 2010" exclusion criteria: * diagnosis of abpa * pregnancy or lactation * active smoking or alcohol using within last 6 months * hiv infection * previous abdominal or rectal surgery * diagnosis of chronic gastrointestinal disease, heart disease, diabetes, severe renal insufficiency (gfr \< 30ml/min) or immunodeficiency * regular use of the following types of medications (\> 2 times per week) within last 2 months: opium, loperamide antidiarrheal, systemic antihistaminic, metoclopramide, proton pump inhibitor * poor compliance or inability to cooperate as judged by the doctor