the heart & mind study

Conditions: Hypertension; Cognitive Decline; Vascular Cognitive Impairment

Summary: older adults with subjective cognitive decline (scd) may represent a portion of the population experiencing early sings of cognitive decline. systolic hypertension is a major contributor to cognitive impairment. high-intensity aerobic interval training (hit) yields greater fitness and vascular health improvements compared to moderate-intensity aerobic continuous training (mct). no randomized controlled trials, however, have investigated the effects hit or mct on cognition in older adults with hypertension and scd. much less is known regarding whether combining hit or mct with mind-motor training would culminate additive benefits to cognition. therefore, the overarching goal of our research is to deliver a group-based exercise program combining mind-motor training with hit or mct to older adults with hypertension and scd. participants will be randomized into two groups. participants in both groups will receive 15 minutes of square stepping exercise (sse) followed by either 45 minutes of hit (n=70) or 45 minutes of mct (n=70). in total, both groups will exercise 60 min/day, 3 days/week for 6 months. the effects of both interventions will be evaluated on systolic and diastolic office/ambulatory blood pressure and global and domain-specific cognitive functioning.


Eligibility criteria:
inclusion criteria: * 55 years of age or older; * present with controlled or uncontrolled stage 1 hypertension (seated, resting clinic sbp 140 to 179 mmhg and/or dbp 90 to 109 mmhg) as per hypertension canada's 2017 guidelines; * have preserved instrumental activities of daily living (scoring \>6/8 on the lawton-brody instrumental activities of daily living \[iadl\] scale); * present signs of scd (defined as answering yes to the question: "do you feel like your memory or thinking skills have gotten worse recently?"); * report being concerned about scd (defined as answering yes to the question: "if yes, are you concerned about the worsening of your memory or thinking skills?"); * preserved objective cognitive performance (i.e., no signs of mci or dementia) defined by scoring ≥ 26 on the montreal cognitive assessment (moca); * must be able to provide written informed consent. exclusion criteria: * present signs of objective cognitive impairment (i.e., signs of mci or dementia), defined by scoring ≤ 25 on the moca combined with study physician consult; * present resting stage 2 hypertension (seated, resting clinic sbp ≥ 180 mmhg and/or dbp ≥ 110 mmhg); * present significant neurological conditions or psychiatric disorders (e.g., parkinson's disease or stroke \<1 year); 4) present history of severe cardiovascular conditions (e.g., recent \[\<1 year\] myocardial infarction, left ventricular hypertrophy) and symptomatic cerebrovascular disease; * present significant orthopaedic conditions (e.g., severe osteoarthritis in the lower limbs); * present untreated clinical depression (i.e., score \>15 on the center for epidemiologic studies - depression scale combined with study physician consult); * unable to comprehend the study letter of information. participants will also be excluded for any other factors that could potentially limit their ability to fully participate in the study.

Keywords: older adults community-based high-intensity interval training (hit) mind-motor training