Kornimate/medical-research-clean huggingface dataset:
comparison of the effects of aerobic exercise and connective tissue massage in postpartum women

Conditions: Postpartum Women

Summary: the aim of this study is to compare the effects of aerobic exercise and connective tissue massage on sleep, mother-infant attachment and psychological state in postpartum women.

postpartum period can affect the mental and physical health of women. women may experience sleep problems and psychological problems due to hormonal changes and newborn care responsibilities. as a result, mother-infant attachment may also be affected. physical activity and exercise should be encouraged in the postpartum period. it is known that aerobic exercises have positive effects on sleep and psychological problems. with the effects of connective tissue massage on the autonomic and circulatory system in the body, positive effects on sleep and psychological state can be achieved, but there are insufficient studies on this subject. in addition, no study has been found to the best of our knowledge comparing the effects of aerobic exercise and connective tissue massage in postpartum women.

Eligibility criteria:
inclusion criteria: * postpartum 6th week-1 year * between the ages of 18-45 * being literate exclusion criteria: * those with orthopedic, neurological, rheumatological, mental or any systemic chronic diseases * those with cardiac problems that may interfere with exercise * those with suspected pregnancy * those with malignancy * those who have infection * those who do not regularly participate in the treatment program

Keywords: sleep, depression, massage, exercise
emergency department ct scanning for appendicitis

Conditions: Appendicitis

Summary: the purpose of this study is to compare iv contrast only vs. iv and oral contrast computed tomography (ct) for the diagnosis of acute appendicitis in adult patients in our emergency department. a secondary purpose will be to design a specific ct for appendicitis protocol at our institution at the conclusion of this study.


Eligibility criteria:
inclusion criteria: * 18 years and older who present to the york hospital emergency department with signs and symptoms suggestive of acute appendicitis, but in whom the diagnosis remains unclear as determined by an attending emergency physician or consulting surgeon and in which a ct scan is needed to further assist in the diagnosis exclusion criteria: * pregnant patients * patients with known iv dye or oral contrast allergy * patients in whom acute appendicitis is not the primary diagnosis * patients with renal insufficiency that may have significant adverse effect from iv dye

Keywords: appendicitis iv contrast oral contrast ct scan
a trauma-informed approach for positive youth development for montana students

Conditions: Depression, Anxiety; Adolescent Behavior; Stress

Summary: given the prevalence of suicide and mental health issues in rural montana, this project is intended to help mitigate stressors that may contribute to poor behavioral and mental health in high school-aged children. the immediate goal is to determine viability of a partnership with a rural southwestern montana school and test the feasibility of a piloted implementation of a trauma-informed yoga intervention to address behavioral health outcomes and positive youth development.


Eligibility criteria:
inclusion criteria: * students enrolled in a specific weight training class at predetermined high school in rural montana exclusion criteria: * students not enrolled in a specific weight training class at predetermined high school in rural montana
effects of thw and rhtsh in glomerular filtration rate during rit

Conditions: Other Impaired Renal Function Disorder

Summary: to observe the influence of thyroid hormone withdrawal and of recombinant human tsh during radioiodine therapy in renal function.

radioiodine therapy in thyroid carcinoma is a procedure performed for over six decades, and there is a vast literature in respect of its value in the complementary treatment of this neoplasia. this procedure also promotes a reliable follow-up based on sequential thyroglobulin dosages and makes possible to reduce the disease recurrence rate. one of the main aspects of the patients preparation before receiving the radioiodine consists in promoting stimulation for an effective uptake of the radioiodine, obtained either by endogenously tsh level elevation after post-surgical thyroid hormone withdrawal, or exogenously after use of recombinant human tsh. this last alternative does not demand suspension of thyroid hormone reposition after total thyroidectomy. although not fully comprehended, it is known that hypothyroidism results in renal function hazard, which is reverted after hormonal reposition. it is also known that renal function modifies the radioiodine residence time and that the longer this time, the greater the patient's radiation exposure will be, and consequently with undesired irradiation of healthy tissues and organs. so theoretically stimulating the patient with recombinant human tsh could avoid the transient deficient renal function, promoting a lower radioiodine residence time and consequently lowering radiation exposure in this therapy. this project aims to evaluate the effects of the different stimulation, endogenous and exogenous, over renal function by glomerular filtration rate determined by 51cr-edta. this will be a controlled and randomized study in which 44 patients that has clinical indication of remnant ablative radioiodine treatment will be prepared by either one of the tsh stimulation procedures. additionally radiation dosimetry calculus will be done to analyze the levels of the patient's radiation exposure associated with each of the uptake stimulation procedures for radioiodine therapy.

Eligibility criteria:
inclusion criteria: * normal renal function exclusion criteria: * abnormal renal function * renal metastasis
dmt310-005 topical in the treatment of acne rosacea

Conditions: Acne Rosacea

Summary: the objective is to evaluate the tolerability, safety, and efficacy of dmt310 topical powder mixed with diluent in male and female patients with moderate to severe facial acne rosacea.


Eligibility criteria:
inclusion criteria: patient is male or non-pregnant female at least 18 years of age. clinical diagnosis of moderate to severe papulopustular acne rosacea as determined by: investigator's global assessment (iga) at randomization score of 3 or 4. patient has at least 15 inflammatory lesions on the face patient is willing to apply the investigational product as directed patient is willing and able to comply with the protocol exclusion criteria: patient is pregnant or planning to become pregnant patient is taking a topical therapy on the face which may affect the patient's rosacea
a multi-centre, double-blinded, randomized, placebo-controlled trial on the efficacy and safety of lopinavir / ritonavir plus ribavirin in the treatment of severe acute respiratory syndrome

Conditions: Severe Acute Respiratory Syndrome

Summary: the study aims to examine whether the combination of lopinavir/ritonavir plus ribavirin for treatment of severe acute respiratory syndrome (sars) is superior to placebo.


Eligibility criteria:
inclusion criteria: * male or female over the age of 18 with a diagnosis of sars and with valid consent will be recruited. exclusion criteria: * subjects with medical conditions that makes the prescription of study medications unsafe are excluded.

Keywords: severe acute respiratory syndrome
effect of diastolic dysfunction on dynamic cardiac monitors

Conditions: Stroke Volume Variation; Diastolic Dysfunction

Summary: this investigator initiated, prospective, observational, single-center study is designed to assess whether dynamic monitors of cardiac function such as stroke volume variation (svv) that have been shown to predict volume responsiveness differ in clinical utility between patients with and without diastolic dysfunction.

this investigator initiated, prospective, observational, single-center study is designed to assess whether dynamic monitors of cardiac function, such as stroke volume variation (svv), that have been shown to predict volume responsiveness differ in clinical utility between patients with and without diastolic dysfunction. specific aims: * determine the threshold for the predictive response of svv with respect to increasing cardiac output for patients with and without diastolic dysfunction. * compare the trans thoracic ultrasound assessment of left ventricular diastolic function before and after the induction of general anesthesia.

Eligibility criteria:
inclusion criteria: * patients undergoing elective surgical procedures where invasive arterial line pressure monitoring is a planned part of the intraoperative management * age greater than or equal to 18 * procedures requiring general anesthesia and mechanical ventilation exclusion criteria: * adults unable to provide consent * atrial fibrillation or other significant active arrhythmia * emergency procedures * hemodynamic instability requiring vasopressor and/or inotropic infusions * presence of an intra-aortic balloon pump * open thoracic procedures * extremes of bmi less than 20 or greater than 40 * pregnancy * prisoners * patient refusal
pharmaceutical care in emergency department

Conditions: Medication Adherence; Hypertension; Diabetes Mellitus

Summary: the purpose of this study is to evaluate the effectiveness of pharmaceutical care, compared to usual care, in patient discharge in an emergency department in patients with hypertension and/or diabetes mellitus type 2.

this is a randomized controlled, single-center study, with blinding of outcome assessors. a pilot study with ten patients was previously conducted in order to test study logistics and data collection instruments. participants will be recruited from a public ed at restinga district in porto alegre, southern brazil.

Eligibility criteria:
inclusion criteria: * blood pressure inadequate control (systolic blood pressure ≥ 160 or diastolic blood pressure ≥ 100 mmhg) or * diabetes mellitus inadequate control( ≥ 200 mg/dl) or hypoglycemia moderate or severe * be referred to clinical care. exclusion criteria: * \< 18 years * not resident of porto alegre * diabetes mellitus type i * unable to answer the questionnaire or to sign the informed consent form * hospital admission * death

Keywords: pharmaceutical care medication adherence blood pressure diabetes emergency
a study to evaluate corrected qt interval from clinical studies conducted with bevacizumab

Conditions: Carcinoma

Summary: this is a supplemental study designed to evaluate the effect of bevacizumab on qtc interval in cancer patients. patients who have consented to participate in selected randomized controlled bevacizumab clinical trials will be invited to participate in this study.


Eligibility criteria:
inclusion criteria: * signed informed consent form * enrollment in one of a list of certain randomized, controlled bevacizumab trials exclusion criteria: * implantable pacemaker or automatic implantable cardioverter defibrillator (aicd) * congenital long qt syndrome * family history of long qt syndrome * clinically significant bradycardia (defined as \< 50 beats/minute)

Keywords: avastin
evaluation of long term safety and efficacy of glepaglutide in treatment of sbs - extension trial

Conditions: Short Bowel Syndrome

Summary: this trial is an extension trial to ease sbs 2. the study looks at whether glepaglutide is a safe treatment for participants with short bowel syndrome (sbs), as well as how well effectiveness is maintained during long term treatment. participants in this trial will receive glepaglutide as once-weekly injections under the skin (subcutaneous, s.c.) for approximately 2 years.


Eligibility criteria:
inclusion criteria: * informed consent obtained before any trial-related activity * completed the full treatment period of the extension trial ease sbs 2 (zp1848-17127) exclusion criteria: * any condition, disease, or circumstance that in the investigator's opinion would put the patient at any undue risk, prevent completion of the trial, or confound the planned assessments of the trial * not having a colonoscopy performed at end of trial in ease sbs 2 (for patients with remnant colon). note. the results of the colonoscopy must not give rise to any safety concerns. a colonoscopy performed within 6 months prior to end of trial and not giving rise to any safety concerns is accepted. for patients with a remnant colon, which is not connected to the passage of foods and is thereby dormant, a computerized tomography (ct) scan or magnetic resonance imaging (mri) will suffice at the discretion of the investigator * use of glp-1, glp-2, human growth hormone (hgh), dipeptidyl peptidase-4 (dpp-4) inhibitors, somatostatin, or analogs thereof within 3 months. note: prior use of glepaglutide trial drug is allowed * females of childbearing potential, who are pregnant, breast-feeding, intend to become pregnant, or are not using highly effective contraceptive methods
evaluation of the tac program

Conditions: Youth with Multimorbidity or Rare Dieases

Summary: this is a mixed-methods evaluative study examining the effectiveness of the transition to adult care program at the hospital for sick children (tac) program on high-risk youth with medical and psychosocial complexity transitioning to adult and/or primary care services. the overarching aim is to study the effectiveness of a new interdisciplinary and holistic transition to adult care program (tac) on health-related outcomes for high-risk youth with multimorbidity or rare diseases and their caregivers by: 1. assess the effect of the tac program on the youth's transition readiness, self-efficacy, self-management, health-related quality of life, and satisfaction. 2. assess the effect of the tac program on the caregiver's satisfaction. 3. explore the experiences, perceptions, needs, and priorities of youth and caregivers participating in the tac program using qualitative research methods. 4. describe the feasibility of the tac program (defined as success in patient recruitment, attendance, participation, retention and transfer).


Eligibility criteria:
inclusion criteria: aged 16-18 years old and have a complex medical history, as defined by: 1. clinical characteristics: multi-morbidity (≥ 3 long-term chronic physical and/or mental health conditions (with primary condition being a physical health condition and/or rare disease/ genetic condition. 2. high risk: no clearly identified adult provider/services following transfer and/or experiencing significant barriers related to social and structural determinants of health. exclusion criteria: 1. moderate to severe developmental/intellectual disabilities 2. followed by services at sickkids which has an established transition program/provider 3. does not provide consent
practice of ventilation in critically ill pediatric patients

Conditions: Critical Illness; Respiratory Failure

Summary: the goal of this worldwide observational study is to investigate ventilation practice in critically ill pediatric patients. the main questions it aims to answer are: 1. what is the global current practice of ventilatory support in critically ill pediatric patients? 2. which potentially modifiable factors related to ventilation are associated with outcome? participating pediatric intensive care units will gather detailed information about ventilation practice and outcome, such as duration of ventilatory support, length of icu stay and icu mortality.

rationale: studies on ventilatory support in critically ill pediatric patients remain scarce and much of the current clinical practice is based upon experience and data originating from critically ill adult patients. objectives: 1. to describe the worldwide practice of ventilatory support in critically ill pediatric patients; and 2. to identify potentially modifiable ventilation parameters that have independent associations with outcome. hypothesis: 1. practice of ventilatory support in critically ill pediatric patients varies substantially worldwide; and 2. potentially modifiable factors related to ventilation have independent associations with outcome in critically ill pediatric patients. study design: international, multicenter, observational cohort study in critically ill pediatric patients. each year, data will be collected in two predefined 4-week periods, one in the winter season and one in the summer season. a third 4-week period will be in case of epi- or pandemics. the study is designed to run for 10 years; within these 10 years, there will be subprojects during pre-defined periods. centers have the option to opt out during certain time periods to make the study manageable for every participating country/center. study population: critically ill pediatric patients (aged 0-18) admitted to the pediatric intensive care unit (picu) and necessitating ventilatory support \> 12 hours. premature infants will be excluded. nature and extent of the burden and risks associated with participation, benefit and group relatedness: because of the observational design of the study using routinely collected data, there is no additional burden for the patient. collection of data from icu charts or electronic medical records systems is of no risk to the patients.

Eligibility criteria:
inclusion criteria: * expected use of (non-)invasive respiratory support for at least 12 hrs exclusion criteria: * premature infants (i.e., postconceptional age corrected for gestational age \< 40 weeks)

Keywords: ventilation practice critically ill children pards mechanical ventilation
safety and efficiency study of pioglitazone in combination with imatinib mesylate to treat chronic myelogenous leukemia

Conditions: Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Summary: the purpose of this study is to assess the safety and efficiency of adding pioglitazone to chronic phase chronic myelogenous leukemia patients having received imatinib mesylate who have acquired a stable molecular response but not complete molecular response.

although tyrosine-kinase inhibitors have profoundly converted the outcomes of chronic myelogenous leukemia patients ,the most of who could have a complete cytogenetic response, a large majority of patients could not come to a complete molecular response that is undetectable in breakpoint cluster region-abelson chimeric oncogene transcripts. according to some previous researches, pioglitazone may target leukemia stem cells and induce them into cell cycle making them exit from quiescent undivided states. subsequently, pioglitazone may gradually erode leukemia stem cells leading to undetectable minimal residual disease. thus the investigators expect to assess the safety and efficiency of pioglitazone in combination with imatinib mesylate in clinical trials. maybe the combination therapy induce more patients in a detectable molecular response into a deeper molecular response. furthermore, pioglitazone may be extensively adapted into the treatment of chronic phase chronic myelogenous leukemia patients as a common protocol.

Eligibility criteria:
inclusion criteria: 1. signed informed consent. 2. treatment with imatinib mesylate for more than 2 years. 3. patients with chronic phase chronic myelogenous leukemia having a complete cytogenetic response and a stable molecular response without complete molecular response. 4. normal important organs such as kidney, liver and heart. exclusion criteria: 1. severe important organs disfunction such as liver and kidney. 2. cardiovascular disease. 3. osteoporosis in therapy. 4. severe fluid retention.

Keywords: pioglitazone chronic myeloid leukemia
meta-iodobenzylguanidine scintigraphy imaging in patients with heart failure and control subjects without cardiovascular disease

Conditions: Heart Failure, Congestive

Summary: the study is designed to study the utility of 123i-mibg as a diagnostic imaging agent to predict cardiac outcomes in subjects with heart failure and in comparison to subjects without cardiovascular disease.


Eligibility criteria:
inclusion criteria: * study subjects must be adults with an established diagnosis of heart failure (new york heart association class ii or iii) and reduced left ventricular ejection fraction (lvef) (≤ 35%) or be healthy volunteers without heart disease. exclusion criteria: * healthy volunteers are not eligible if they have a history diabetes mellitus, signs/symptoms of neurological disease (eg, parkinson's disease, multiple system atrophy, parkinsonian syndromes), or other diseases known to affect the sympathetic nervous system. * subjects with new york heart association class i or iv heart failure are not eligible.

Keywords: heart failure nuclear cardiology sympathetic innervation 123i-mibg
electronic physician notification to facilitate the recognition and management of severe aortic stenosis: the detect as trial

Conditions: Aortic Stenosis

Summary: the detect as trial is a randomized clinical trial and quality improvement initiative that seeks to investigate the impact of electronic provider notification of severe aortic stenosis (as) on its management, on the utilization of aortic valve replacement (avr), and on ethnic and racial disparities in avr utilization. after the investigators identify patients in whom echocardiography shows severe aortic stenosis, defined by an aortic valve area (ava) \<1.0cm2, the ordering provider of the echocardiogram will then be randomly assigned to either the intervention group or to the control group. providers randomly assigned to the intervention group will be sent an electronic (email or message via the electronic health record) physician notification for every one of their patients with severe aortic stenosis on tte. electronic notification will also highlight relevant acc/aha clinical practice guideline recommendations regarding the management of severe as. no intervention will be performed for patients belonging to physicians assigned to the control group. the primary endpoint will be avr utilization, defined as the proportion of patients with a clinical indication for severe as that undergo avr. clinical indications will be based upon the 2020 aha/acc clinical practice guidelines for valvular heart disease. secondary end-points will be mortality, heart failure hospitalization, tte utilization/surveillance, as billing code diagnosis, and cardiology/heart valve team referral. pre-defined subgroup analyses will be performed to assess avr utilization among women, racial/ethnic minority groups, low-gradient as, cardiologist and non-cardiologist ordering provider, and inpatient and outpatient practice settings.


Eligibility criteria:
inclusion criteria: * subjects with severe aortic stenosis having an aortic valve area of less than or equal to 1.0cm2. exclusion criteria: * subjects with bioprosthetic or mechanical valves in the aortic position

Keywords: aortic valve stenosis aortic valve disease heart valve diseases heart diseases cardiovascular diseases aortic valve replacement