Kornimate/medical-research-clean huggingface dataset:
metabolic reprogramming therapy for treatment of recurrent head and neck cancers

Conditions: Head and Neck Cancer; Head and Neck Cancers

Summary: the purpose of this study is to study the effect of the drug dca (dichloroacetate) on recurrent head and neck cancers. part of this study will also use ef5 pet scan to study tumor hypoxia.


Eligibility criteria:
inclusion criteria: * pathologically confirmed head and neck squamous cell carcinoma * age \> 18 years old * patients must have unresectable disease in which there is no accepted potentially curative treatment option * patients must have acceptable organ and marrow function as defined below: * leukocytes \>3,000/ul * absolute neutrophil count \>1,500/ul * platelets \>90,000/ul * total bilirubin \<=1.5x normal institutional limits * ast(sgot)/alt(sgpt) \<=2.5 x normal institutional limits with the following exceptions: 1. patients with documented tumors involving the liver who have grade \<2 elevations in ast, alt, and/or alkaline phosphatase are eligible if \<5x uln. 2. patients with documented tumors involving bone who have a grade \<2 elevation in alkaline phosphatase are eligible if \<5x uln. * creatinine \ 50 ml/min on the basis of the cockcroft-gault glomerular filtration rate estimation * patients must have non-cranial gross disease that is greater than 1 cm on ct scan prior to enrollment * disease must be fdg-avid on pet scanning * creatinine within normal institutional limits * eastern clinical oncology group performance status 0, 1 or 2 (appendix 1) * life expectancy \> 12 weeks * both men and women and members of all races and ethnic groups are eligible for this trial. exclusion criteria: * women who are pregnant * administration of any systemic cytotoxic agents within the last 2 weeks of enrollment * patients who are unwilling or unable to provide informed consent * patients who have potentially curable disease * participation in another concurrent treatment protocol
behavioral and cognitive therapies for auditory hallucination management

Conditions: Chronic Psychosis

Summary: the present study wants to evaluate the efficacy of a short psychoeducational type group intervention and cognitive behavioral therapy (cbt) 3rd wave on the severity of hallucinatory acoustico-verbal (hav) symptomatology in patients with schizophrenia.


Eligibility criteria:
inclusion criteria: * schizophrenic disorders, schizo-affective disorders * suffering from persistent hav * no change in symptomatology for 3 months. * no anticipated change in antipsychotic treatment (anti-hallucinatory): olanzapine, risperidone, amisulpride, quetiapine, aripiprazole, loxapine, haloperidol, clopixol, modecate, nozinan, cyamemazine, piportil, clozapine * major patient, or major incompetent. exclusion criteria: * mental retardation * subject participating in another search including an exclusion period still in progress at pre-inclusion

Keywords: behavioral and cognitive therapies
association between carotid plaque length and cardiovascular outcomes

Conditions: Coronary Artery Disease; Carotid Plaque

Summary: this multicenter study involved 5 hospitals (changhai hospital; yueyang hospital of shanghai university of traditional chinese medicine; gongli hospital; putuo hospital of shanghai university of traditional chinese medicine; no. 904 hospital of the pla joint logistics support force wuxi). the study enrolled 5000 consecutive patients without known cad who underwent first coronary angiography for stable chest pain and carotid ultrasound was performed during hospitalization from january 2017 through december 2018.

patients who had obstructive cad (defined as ≥50% luminal stenosis) confirmed by coronary angiography and who underwent carotid scanning were included in the final analysis.carotid ultrasonography was performed simultaneously, and carotid intima-media thickness (imt), maximum thickness and length of all plaques were measured.the incidence of major adverse cardiovascular events was recorded during follow-up.

Eligibility criteria:
inclusion criteria: * patients who underwent coronary angiography for stable chest pain and carotid ultrasound simultaneously; * patients with obstructive cad (≥50% coronary stenosis); exclusion criteria: * \<18 years of age; * previous carotid surgery or significant carotid artery disease; * prior stroke or transient ischemic attack; * previously documented cad (including history of myocardial infarction, acute coronary syndrome, or coronary revascularization);

Keywords: carotid artery ultrasound carotid plaque coronary artery disease
bilateral vs. unilateral erector spinae plane block

Conditions: Postoperative Pain; Cholecystitis; Gallstone

Summary: the importance of multimodal analgesia for postoperative pain management is well known and regional anesthesia techniques are commonly prefferred to provide better analgesia. erector spinae plane block (esb) is a new defined and effective regional anesthesia technique. but two injections can be unconfortable for some patients. with this study, we aimed to compare the analgesia effect of bilateral and unilateral esp block for laparoscopic cholecystectomy.


Eligibility criteria:
inclusion criteria: * asa i-ii patients * pateints undergoing elective laparoscopic cholecystectomy exclusion criteria: * obesity (body mass index \>35 kg/m2) * infection of the skin at the site of needle puncture area * patients with known allergies to any of the study drugs * coagulopathy * recent use of analgesic drugs

Keywords: erector spinae plane block postoperative pain laparoscopic cholecystectomy
eculizumab to enable renal transplantation in patients with history of catastrophic antiphospholipid antibody syndrome

Conditions: Antiphospholipid Antibody Syndrome; End Stage Renal Disease

Summary: catastrophic antiphospholipid antibody syndrome (caps) is a rare condition in which life-threatening blood clots form in multiple organs simultaneously and can lead to multi-organ system failure and death. the causes of caps are not entirely understood, but caps episodes are often triggered by stressful events such as infections, surgery, or trauma. for patients who survive an episode of caps, permanent kidney failure is not uncommon because the kidneys are the organ system most frequently affected in caps. kidney transplantation is the treatment of choice for end-stage kidney disease, but patients with a history of caps are exceptionally high-risk kidney transplant recipients because the chance that surgery itself could trigger a life-threatening or transplant-threatening episode of caps is significant. as a result, patients with caps are not generally considered candidates for transplantation. despite this, these patients have a severely decreased life-expectancy on dialysis and their long-term survival and quality of life would be greatly increased by a successful kidney transplant. in this trial, a drug called eculizumab will be tested for its ability to prevent caps after kidney transplantation in patients with a prior history of caps. eculizumab is an inhibitor of the complement system, which is believed to be important in generating the inflammatory environment that leads to diffuse clotting of blood vessels in caps. the investigators hypothesize that by blocking the complement cascade using eculizumab, in conjunction with blocking the coagulation system, that kidney transplantation can be safely and successfully performed in patients with a history of caps.


Eligibility criteria:
inclusion criteria: * age 18 years or older * history of catastrophic antiphospholipid antibody syndrome (caps) * end-stage renal disease exclusion criteria: * any contraindications to transplantation other than caps * pregnant women * women who intend to become pregnant over the study period * ongoing or untreated meningococcal infections * history of serious adverse reaction to eculizumab

Keywords: caps kidney transplant renal transplant catastrophic antiphospholipid antibody syndrome
picsi impact on euploidy in assisted reproduction

Conditions: Infertility

Summary: hyaluronic acid (ha) is a major component of the cumulus complex surrounding oocytes. intracytoplasmic sperm injection (icsi) involves injection of a selected sperm into the oocyte. embryologists select sperm with normal morphology and progressive motility. physiologic intracytoplasmic sperm injection (picsi) involves sperm selection for icsi based on hyaluronan binding. mature sperm which bind to ha have greater genomic integrity and reduced levels of dna fragmentation. earlier observational studies demonstrated improved outcomes in assisted reproductive technologies (art) including improved clinical pregnancy rates, decreased miscarriage rates and higher live birth rates. a large multicentre randomized trial, the habselect trial, which included over 2,500 couples, found that picsi did not improve term (\>37 weeks gestation) live birth rates compared to standard icsi. however, mechanistic analysis of the data from the habselect trial showed a significant reduction in miscarriage rates, most notable in couples where the woman was aged over 37 years where a significant reduction in miscarriage rate was seen (40% with icsi vs 15% with picsi). a 2021 retrospective sibling oocyte study, including 45 cycles, compared fertilisation and embryo development and found higher fertilisation rate in picsi cycles. no difference was observed in clinical pregnancy rates; miscarriage rates and live birth rates were not reported. we aim to prospectively study picsi vs standard icsi in sibling oocytes to investigate if picsi improves embryological and art outcomes, particularly fertilisation rate, embryo euploid status and miscarriage rate, where the female patient is aged over 35 years.


Eligibility criteria:
inclusion criteria: * couples undergoing a planned icsi-pgt-a cycle using their own fresh gametes * female age \> 35 years and/or male age \> 40 years * minimum of two mature eggs at time of egg maturity assessment exclusion criteria: * couples undergoing a planned ivf cycle (even if converted to icsi) * patients using donor gametes for an icsi cycle * patients using frozen gametes for an icsi cycle

Keywords: picsi sperm aneuploidy
comparison of self directed learning and small group teaching methods on pressure injury assessment

Conditions: Pressure Ulcer

Summary: the purpose of this study is to determine the effect of pressure injury assessment training given by self-directed learning and small-group teaching methods on the knowledge and skill levels of nursing students: a three-group, pre-test - post-test, randomized controlled, parallel-group experimental study.

pressure injury is a common health problem worldwide. the global prevalence of hospital-associated pressure injuries was 8.4%. regular wound assessment is required to determine appropriate treatment methods, monitor wound healing, and identify complications early in the pressure injury treatment process in order to achieve clinical goals. according to the literature, nurses and nursing students have a low level of knowledge about pressure injury and there is a knowledge gap between nurses' knowledge of pressure injury and pressure injury practices. as a result, it is necessary to teach skills so that they can put their knowledge into practice. individuals born after 2000, referred to as generation z, make up the majority of students beginning undergraduate education today. the most significant difference between generation z and other generations is that they were born during a period when digital high technology was widely used. this generation, also known as the "internet generation," is constantly surrounded by new technological opportunities, communication, and transportation facilities. because of these characteristics, it is critical to use teaching methods that will appeal to them when educating students in this group. in a classroom, there are fast and slow learners. the amount of time allotted to students naturally decreases as the number of students in the class grows. furthermore, student differences prevent the entire class from learning at the same time. some students do not learn right away, others later, and still others do not learn at all in such a classroom. education should be personalized in order to eliminate all of these non-occurrences.with the widespread use of smart phones today, mobile learning has become commonplace. students gain clinical practice skills and experience when mobile technology is used as a support tool in nursing education practices. for this purpose, the trainings to be given with the mobile application in this study will be supported by the activities in which the students can practice individually in the skill laboratory.

Eligibility criteria:
inclusion criteria: * to be registered for the nursing vocational application course * volunteering to participate in the research * having a mobile device (smartphone, tablet pc etc.) exclusion criteria: * to have received training on the evaluation of pressure injuries other than the basic nursing education

Keywords: pressure ulcer self-directed learning small-group learning pressure injury pressure injury assessment
comparison study of the effect of enema in anal surgery

Conditions: Hemorrhoids; Fistula

Summary: to evaluate whether receiving enema before anal surgery or not affects the postoperative recovery and complications.

for patients undergoing anal surgery, some of them receive enema as doctors' preference before the surgery in consider to lower postoperative complications e.g. infection, while others do not. these choices are often determined by surgeons' personal preference according to their experiences due to lack of evidence from researches. hemorrhoidectomy and fistulotomy are the most common two types of surgery in colon and rectal surgery division in shuang ho hospital, where top three quantities of hemorrhoidectomy in taiwn have been performed.therefore, we conducted a randomized controlled trial to evaluate the benefits of enema before anal surgery and possible waste of medical resources.

Eligibility criteria:
inclusion criteria: * patients who underwent hemorrhoidectomy, including circular stapled hemorrhoidopexy (pph) and conventional hemorrhoidectomy * patients who underwent fistulotomy or fistulectomy exclusion criteria: * emergency surgery * surgery other than circular stapled hemorrhoidopexy (pph) and conventional hemorrhoidectomy, e.g., rubber band ligation, injection treatment, and cryosurgery * complicated fistulectomy, e.g., requiring surgical drainage and seton placement * other types of anal surgery, e.g., anal fissure and colorectal cancer * liver cirrhosis * coagulation dysfunction * bedridden * human immunodeficiency virus infection
levetiracetam versus phenytoin in management of pediatric status epilepticus

Conditions: Comparison; the Efficacy of Levetireacetam; Phenytoin; Management of Pediatric Status Epilepticus

Summary: the study will be conducted on 60 children suffering from status epilepticus who will be admitted to pediatric neurology unit and pediatric icu of tanta hospital university.

the aim of this work is to compare the efficacy of levetireacetam and phenytoin in management of pediatric status epilepticus.

Eligibility criteria:
inclusion criteria: * children suffering from convulsive generalized tonic clonic status epilepticus at any age. exclusion criteria: * non convulsive status epilepticus. * children with known contraindication or allergy to levetireacetam or phenytoin.

Keywords: levetireacetam phenytoin status epilepticus children
transperineal laser ablation for low- and intermediate risk prostate cancer: a single cohort analysis

Conditions: Prostate Cancer

Summary: the goal of this prospective study is to test the efficacy of echolaser transperineal focal therapy in patients with low- and intermediate risk prostate cancer. the main question it aims to answer are: 1. short and intermediate term oncological outcomes after laser focal therapy, 2. functional outcomes and quality of life after treatment. participants affected by low risk prostate cancer will undergo trans perineal laser focal therapy. multiparametric prostate mri will be perform after 3 and 12 months for oncological control. re-fusion biopsy will be perform after 12 months. functional outcomes and quality of life will be assess at 3, 6 and 12 months.


Eligibility criteria:
inclusion criteria: * patients with low- and intermediate risk prostate cancer classified as international society for urological pathology, isup 1-2. exclusion criteria: * patients diagnosed with urothelial cancer * contraindications for mri * multifocal prostate cancer

Keywords: prostate cancer focal therapy echolaser transperineal laser ablation tpla
vaginal cuff dehiscence at total laparoscopic hysterectomy

Conditions: Surgical Wound Dehiscence

Summary: the aim of this study is to assess a major complication of total laparoscopic hysterectomy, vaginal dehiscence, with two different colpotomy techniques. with this aim patients to be operated for laparoscopic hysterectomy will be randomized to two different techniques. the colpotomy will be undertaken by 'cut mode' in the first group and 'coagulation mode' in the second group. all of the operations will be preformed by the same surgical at a university hospital. vaginal dehiscence after surgery is the primary outcome measure.


Eligibility criteria:
inclusion criteria: * all total laparoscopic hysterectomies performed by a single surgeon * both benign and malignant cases * completed laparoscopically * intracorporeal vaginal cuff suturing exclusion criteria: * robotic hysterectomies * pelvic infection within 30 days before surgery * conversion to laparotomy
coblation in endoscopic sinus surgery

Conditions: Blood Loss

Summary: chronic rhinosinusitis (crs) refers to a pathological condition where the sinonasal mucosa is inflamed for greater than 12 weeks(1). it is associated with a constellation of symptoms, including facial pain, anosmia, and nasal congestion. it has been estimated that crs affects close to 5% of the canadian population(2). when medical therapy fails, patients are often referred to otolaryngology- head and neck surgeons for consideration of surgical management. endoscopic sinus surgery (ess) is one of the mainstays of therapy for crs that has failed medical management(3). traditionally, the microdebrider has been the go-to tool for performing these surgeries, but recently the coblator (arthrocare, austin, texas) has begun to define its' role in surgery. by using bipolar radiofrequency energy to ablate tissue (with temperatures up to 60˚ c)(4), theoretically the coblator will result in less bleeding than so-called "cold" surgical techniques (i.e. the microdebrider). in a retrospective study by eloy et. al, patients with crs and nasal polyposis had a statistically significant amount of less intraoperative blood loss when the coblator was used in their surgery, than those patients who underwent surgery with the microdebrider. the investigators plan to further investigate this in a randomized, controlled fashion


Eligibility criteria:
inclusion criteria: * between 18-70 years old, and * having a diagnosis of crs. exclusion criteria: * previous endoscopic sinus surgery, * coagulopathies, * being pregnant, or * being prescribed anti-coagulants or anti-platelet agents

Keywords: blood loss between two groups
registry for advanced sarcodiosis

Conditions: Sarcoidosis

Summary: registry with evaluation and genetic information of patients with advanced sarcoidosis and matched sarcoidosis


Eligibility criteria:
inclusion criteria * patients with diagnosis of sarcoidosis based on ats/wasog criteria 22 * age ≥ 18 years. * life expectancy of at least 2 years. * pulmonary function tests (spirometry) within one month of entry or willing to under pulmonary function testing on the day of study enrollment * sarcoidosis as characterized as either advanced or non-advanced (see protocol for definition of advanced disease) * subjects must be able to understand and be willing to sign the written informed consent form. a signed informed consent form must be appropriately obtained prior to the conduct of any trial-specific procedure. exclusion criteria * subjects with a medical disorder, condition, or history of such that would impair the subject's ability to participate or complete this study in the opinion of the investigator * inability to comply with the protocol and/or not willing or not available for follow-up assessments. * any condition which, in the investigator's opinion, makes the subject unsuitable for trial participation.

Keywords: neurosarcoidosis, pulmonary hyeprtension, infliximab, repository corticotropin
a study to evaluate the safety and efficacy of bgb-16673 compared to pirtobrutinib in adults with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma

Conditions: Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma

Summary: the purpose of this study is to evaluate the efficacy and safety of bgb-16673 alone compared with pirtobrutinib in patients with relapsed or refractory (r/r) chronic lymphocytic leukemia (cll) or small lymphocytic lymphoma (sll) who had been previously treated with a covalent bruton tyrosine kinase inhibitor (cbtki).


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of cll or sll, requiring treatment, based on 2018 iwcll criteria * previously received treatment for cll/sll with a covalent bruton tyrosine kinase inhibitor (cbtki). patients should have disease relapsed after or refractory to at least 1 line of therapy including a cbtki. * participants with sll must have measurable disease by computed tomography/magnetic resonance imaging, defined as ≥ 1 lymph node \> 1.5 cm in longest diameter and measurable in 2 perpendicular diameters. exclusion criteria: * known prolymphocytic leukemia or history of, or currently suspected, richter's transformation. * history of known bleeding disorder such as hemophilia a, hemophilia b, von willebrand disease, or history of spontaneous bleeding requiring blood transfusion or other medical intervention * history of ischemic stroke or intracranial hemorrhage within 6 months before first dose of study drug * prior exposure to any bruton tyrosine kinase (btk) protein degraders or noncovalent bruton tyrosine kinase inhibitor (ncbtki). * current or history of central nervous system involvement including the brain, spinal cord, leptomeninges, and cerebrospinal fluid (as documented by imaging, cytology, or biopsy) by cll/sll note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: noncovalent bruton tyrosine kinase inhibitor bruton tyrosine kinase-targeted protein degrader
bioequivalence of two tablet forms of mk0974 (0974-045)

Conditions: Migraine

Summary: this study will evaluate the bioequivalence of two solid dose formulations of mk0974.


Eligibility criteria:
inclusion criteria: * subject is in good health * subject is a non-smoker * subject is willing to comply with the study restrictions exclusion criteria: * subject has a history of stroke, chronic seizures, or major neurological disorder * subject has a history of cancer * subject is a nursing mother * subject has or has a history of any disease or condition that might make participation in the study unsafe or that might confound the results of the study