Kornimate/medical-research-clean huggingface dataset:
optimizing gestational weight gain for prevention of gestational diabetes mellitus in malaysia

Conditions: Pregnant Women

Summary: gestational weight gain (gwg) has been closely related to health outcomes, particularly in gestational diabetes mellitus (gdm). pregnant women may be particularly motivated to make healthy lifestyle changes. previous studies showed that lifestyle modification interventions (diet and exercise) may be successful in reducing gwg in high-risk women but their effects on the incidence of gdm and other adverse perinatal outcomes have been limited. the research question for the future full randomized trial is whether an optimizing healthy gwg programme focusing on lifestyle (diet and physical activity) feasible to decrease the risk of gdm in a developing country. thus, this study aims to evaluate the effectiveness of a web/smartphone-based lifestyle program in optimizing gestational weight gain (gwg) to prevent the incidence of gdm.

general objective: to determine the effectiveness of a web/smartphone-based lifestyle program on optimizing gestational weight gain (gwg) to prevent the incidence of gdm. specific objectives: 1. to compare changes in the primary outcome (incidence of gdm) between pregnant mothers receiving web/smartphone-based lifestyle program (i.e. intervention group) and pregnant mothers not receiving web/smartphone-based lifestyle program (i.e. control group). 2. to compare changes in the secondary outcomes (gwg, dietary intake and physical activity) between pregnant mothers receiving web/smartphone-based lifestyle program (i.e. intervention group) and pregnant mothers not receiving web/smartphone-based lifestyle program (i.e. control group). study location: a total of nine (9) states are randomly selected to represent the northern, southern, east coast and central regions of peninsular malaysia. the states are then randomly assigned to either the intervention states or control states. all maternal and child health (mch) clinics in the top five highest populated districts are purposively selected. study design: this is a cluster-randomized, controlled trial (rct), whereby states as clusters and will be randomly allocated into either intervention or control group. all pregnant women in each cluster will be included in the study.

Eligibility criteria:
inclusion criteria: * malaysian women * at any trimester of pregnancy * all ethnicities (malays, chinese or indians) * with or without diseases (diabetes mellitus with/ without insulin, hypertension, dyslipidaemia, overweight/ obese) exclusion criteria: * medical diagnosis with major psychiatric problems (bipolar depression, schizophrenia, suicidal risk) * severe comorbidities (eg cardiac diseases, kidney diseases severe anemia) that require specific interventions

Keywords: health and nutrition education (hne) resources web/smartphone-based lifestyle program gestational diabetes mellitus gestational weight gain
the acute effect of protein or carbohydrate intake on testosterone levels and food intake in children and adolescent boys

Conditions: Appetitive Behavior; Pediatric Obesity

Summary: the purpose of this study was to determine the effect of acute protein and glucose intake on testosterone levels measured in adolescent boys and determine whether changes in testosterone levels are associated with alterations in short-term food intake. it was hypothesized that 1) ingestion of a protein beverage would result in no change of testosterone levels whereas glucose would result in a significant decrease of testosterone levels 60 minutes after ingestion and 2) decreases of testosterone levels as a result of the glucose preload would predict food intake for boys of similar body size. the first objective was to investigate the effect of an acute protein or glucose drink on testosterone levels and the second objective was to determine whether changes of testosterone levels associate with food intake.


Eligibility criteria:
inclusion criteria: * 9-18 years, healthy, male. exclusion criteria: * history of prematurity, chronic illness, were taking any medications known to affect glucose homeostasis, appetite or pubertal development.

Keywords: testosterone food intake appetite
concurrent chemoradiotherapy with nedaplatin versus cisplatin in nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma

Summary: this is a phase iii trial to study the effectiveness of nedaplatin versus cisplatin with imrt chemoradiotherapy in treating patients with locoregionally advanced nasopharyngeal carcinoma.

nasopharyngeal carcinoma (npc) is endemic in southern china and southeast asia. several prospective randomized trials have demonstrated that concurrent chemoradiotherapy was superior to radiotherapy alone in the treatment of locoregionally advanced npc. cisplatin-based chemotherapy has been shown to have higher response rates in npc than noncisplatin regimens. however, the patients' compliance was unsatisfactory because the obvious gastrointestinal toxicity of cisplatin. nedaplatin is the new second generation platinum and it has slight gastrointestinal reaction. our trial is in order to study the effectiveness of nedaplatin or cisplatin with intensity-modulated radiation therapy (imrt) chemoradiotherapy in treating patients with locoregionally advanced npc.

Eligibility criteria:
inclusion criteria: * patients with newly histologically confirmed non-keratinizing nasopharyngeal carcinoma, including who ii or iii * original clinical staged as t1-4n1-3 or t3-4n0（according to the 7th ajcc edition） * no evidence of distant metastasis (m0) * male and no pregnant female * age between 18-65 * wbc ≥ 4,000/mm3 and plt ≥ 100,000/mm3 * with normal liver function test (alt、ast ≤ 2.5×uln) * with normal renal function test (creatinine ≤ 1.5×uln) * satisfactory performance status: karnofsky scale (kps)\> 70 * without radiotherapy or chemotherapy * patients must give signed informed consent exclusion criteria: * patients have evidence of relapse or distant metastasis * the presence of uncontrolled life-threatening illness * receiving other ways of anti-cancer therapy * receiving radiotherapy or chemotherapy * pregnancy or lactation
optimum-pressure for reducing postoperative shoulder-tip pain in laparoscopic cholecystectomy

Conditions: Pain, Postoperative

Summary: laparoscopic cholecystectomy (lc) is the standard treatment of gallbladder disease. lc is the common procedure for general surgeons. although lc is a safe procedure with very low mortality (\<1%), it has some associated major morbidity. bile duct injury is the most serious complication of lc. however, there are some postoperative morbidity including shoulder-tip pain. the incidence of shoulder-tip pain is about 15-45%, which might be influencing the patient outcome including length of hospital stay. from the previous studies, one of the important factor associated with this condition is pneumoperitoneum pressure. thus, the suggestion of the intra-abdominal pressure should be low pressure as about 8 mmhg. however, the optimum pressure for the low-pressure during laparoscopic cholecystectomy is controversial.

we designed the prospective randomized controlled trial to comparing the postoperative shoulder tip pain between two low pressure level (8 and 10 mmhg) during laparoscopic cholecystectomy. after the enrolled participant signed the inform consent, the participant was randomly assigned to 8 or 10 mmhg group. the standard procedure of the laparoscopic cholecystectomy was performed by experience surgeons. during the operation, the pressure limit can be adjusted to facilitate the procedure according to the surgeons. following the operation, the investigator will ask about the shoulder tip pain from the participant during 48 hours. the standard of care including pain medication during postoperative period was performed.

Eligibility criteria:
inclusion criteria: 1. age \> 15 years 2. elective procedure of laparoscopic cholecystectomy 3. sign to inform consent exclusion criteria: 1. emergency surgery 2. concomitant other procedure performed 3. deny to participant
a study of tarceva (erlotinib) as first line therapy in participants with non-small cell lung cancer harbouring epidermal growth factor receptor (egfr) mutations

Conditions: Non-Squamous Non-Small Cell Lung Cancer

Summary: this open-label, single arm study will evaluate the safety and efficacy of tarceva (erlotinib) as first-line therapy in participants with stage iv or recurrent non-small cell lung cancer who harbour epidermal growth factor receptor (egfr) mutations. all participants will receive tarceva 150 mg daily orally until disease progression or unacceptable toxicity occurs. at the investigator's discretion, participants may receive tarceva beyond disease progression.


Eligibility criteria:
inclusion criteria: * adult participants, \>/= 18 years of age * stage iv or recurrent non-small cell lung cancer (nsclc) * presence of mutation(s) in exon 18 through exon 21 of epidermal growth factor receptor (egfr), (except t790m single mutation only) * measurable disease (at least one lesion \>= 10 mm in longest diameter) * eastern cooperative oncology group (ecog) performance status 0-2 * adequate hematological, renal and liver function exclusion criteria: * patients with t790m single mutation only * prior exposure to agents directed at the human epidermal receptor (her) axis, e.g. erlotinib, gefitinib, cetuximab, trastuzumab * prior chemotherapy or systemic anti-cancer therapy for advanced nsclc disease * symptomatic or uncontrolled central nervous system (cns) metastases * other malignancy within the last 5 years, except for carcinoma in situ of the cervix, or basal or squamous cell carcinoma of the skin, or surgically treated localized prostate cancer, or surgically treated ductal cell carcinoma in situ of the breast * any significant ophthalmologic abnormality * pre-existing parenchymal lung disease such as pulmonary fibrosis * use of coumarins (for anti-coagulation therapy the use of low molecular weight heparin is recommended instead)
sleep impairments in refugees diagnosed with ptsd

Conditions: PTSD; Sleep Disorder

Summary: the aim of this study is to examine sleep architecture in refugees with ptsd. polysomnography (psg) will be carried out to study the occurrence of sleep disorders in patients and healthy controls.

there is little knowledge on treatment of sleep disturbances in trauma-affected refugees and this study will be the first to record the biophysiological changes that occur during sleep in refugees with ptsd. the study is a proof-of-concept study and this will contribute with new and potentially crucial knowledge of sleep disturbances in these patients. the project is designed as a cross-sectional study with 20 refugees with ptsd referred to the specialised outpatient clinic, competence centre for transcultural psychiatry (ctp), and 20 healthy control subjects. all patients referred to ctp will be invited to an initial consultation with a doctor. during this consultation a diagnostic assessment will be performed and the clinical history will be obtained. patients who give informed consent will be invited to participate in the project and have sleep measurements performed by psg. furthermore self-administered questionnaires and semi-structured interviews will be used to collect information on mental health, sleep quality, sleep length and nightmares. each patient will be equipped with psg equipment to do measurements at home for one night (12 hours). healthy control subjects will fill out the same ctp standard ratings and have the same diagnostic assessment and psg measurement. the hypothesis is that the sleep architecture in refugees with ptsd differ from healthy controls. it is suggested that refugees with ptsd have increased dream activity as well as increased incidence of sleep disorders such as rapid eye movement (rem) sleep without atonia (rswa), rem sleep behaviour disorder (rbd), sleep apnea and periodic limb movement disorder (plm). the study is performed in collaboration with danish centre for sleep medicine in denmark.

Eligibility criteria:
inclusion criteria: * adults (18 years old or above) * refugee or family reunification refugees * ptsd according to the icd-10 criteria's * signed informed concent exclusion criteria: * severe psychotic disorder (defined as patients with icd-10 diagnoses f2x and f30.1-f30.9) * harmful use of alcohol (icd-10 diagnosis f1x.1) * serious or progressive somatic illnesses that the lead investigator finds interfering for the study * medical treatment with antipsychotics, benzodiazepine, opioids, cns stimulants or regular use of anti histamine * bmi \>35 * pregnancy

Keywords: polysomnography refugees
brain health program for older adults with subjective cognitive decline

Conditions: Memory Loss (Excluding Dementia); Healthy Lifestyle; Risk Reduction Behavior

Summary: the investigators will compare two brain health programs in older adults with subjective cognitive decline and lifestyle risk factors for dementia. the primary aim of the study is to determine the credibility, expectancy, feasibility, acceptability, appropriateness, fidelity, and satisfaction of the programs.

the investigators aim to promote brain health by reducing lifestyle risk factors for dementia in older adults with subjective cognitive decline (scd). this study is a pilot randomized control trial (rct) comparing two virtual lifestyle programs, my healthy brain 1 and my healthy brain 2. eligible older adults include: age ≥ 60, self-reported worry about changes in memory or thinking, and risk factors for dementia (determined by the cardiovascular risk factors, aging, and incidence of dementia score ≥ 6). participants will be randomized to one of two groups (my healthy brain 1 or my healthy brain 2) and will complete 8 weekly 90-minute sessions via zoom delivered by a clinical psychologist. each session will focus on a different topic relevant to brain health (e.g. physical activity, sleep, etc.). the primary aim of the study is to determine the credibility, expectancy, feasibility, acceptability, appropriateness, fidelity, and satisfaction of the programs. the investigators will also explore improvements in cognition, lifestyle behaviors (physical activity, sleep, nutrition, alcohol and tobacco use, social functioning), depression, anxiety, and mindfulness assessed at baseline, post-intervention, and 6 month follow-up. all participants will wear a watch to monitor changes in lifestyle during the program.

Eligibility criteria:
inclusion criteria: * concerns about memory or thinking (subjective cognitive decline, scd) aged 60 or older * cardiovascular risk factors, aging, and incidence of dementia (caide) ≥ 6 * telephone interview for cognitive status-41 ≥ 31 * functional assessment questionnaire \< 9 * english fluency/literacy * ability and willingness to participate via live video * no self-reported safety issues with initiating lifestyle changes during the study exclusion criteria: * mild cognitive impairment, dementia, or neurodegenerative disease * psychotropic medications (e.g., antidepressant) change in the last 3 months * psychosis, uncontrolled bipolar disorder or substance dependence; schizophrenia or schizoaffective disorder * current self-report of suicidal ideation * serious medical illness expected to worsen in 6 months (e.g., cancer) * use of digital monitoring device (e.g., fitbit) in the last 3 moths and unwillingness to stop using personal digital monitoring device for duration of program * mindfulness or mind-body practice (\> 45 min/wk) focused on lifestyle, cognitive-behavioral therapy in \< 3 months, or participation in a lifestyle prevention program (ex: diabetes prevention) in \< 3 months * average daily step count \> 5,000 steps * more than 30 minutes of exercise daily
entry into comprehensive methadone treatment via interim maintenance

Conditions: Opiate Dependence

Summary: the purpose of the study is to determine whether one of three levels of counseling intensity will be associated with better treatment outcomes when combined with methadone maintenance treatment for heroin-addicted adults drawn from a methadone treatment program waiting list.

waiting lists for methadone treatment programs persist, and new and more effective approaches for expanding treatment access and improving outcomes for heroin dependent individuals are needed. recently completed research demonstrated that so-called "interim methadone maintenance" (i.e., methadone with crisis counseling only, for individuals on waiting lists) was associated with greater entry into methadone treatment, less self-reported heroin and cocaine use, lower rates of opioid-positive drug tests, and lower rates of self-reported crime. the present study will build on this work by comparing three levels of counseling provided with methadone treatment: 1)"interim" methadone treatment; 2) "comprehensive" methadone treatment (which is the name for the usual amount of counseling provided, i.e., about once per week) and; 3)"restored" methadone treatment in which the counselors will have a lower case load and will be able to provide more attention to their patients.

Eligibility criteria:
inclusion criteria: * adult * meets criteria for methadone maintenance * unable to gain admission to methadone program within 14 days exclusion criteria: * pregnant * acute medical or psychiatric illness

Keywords: heroin dependence interim methadone treatment counseling
quality of life in adult neurological patients

Conditions: Spinal Cord Injury; Acquired Brain Injury; Poliomyelitis

Summary: the purposes of this study were to evaluate the influence of an interdisciplinary rehabilitation program in the improvement of the health-related quality of life among adult neurological patients and to identify the sociodemographic and clinical associated characteristics. subjects with spinal cord injury, acquired brain injury and poliomyelitis survivors participated in the study. all participants underwent a rehabilitation program (rp) from january 2008 through july 2010, which consists of 40-minutes of many therapies for 1-2 days a week. the whoqol-bref was applied at the initial and discharge assessments.


Eligibility criteria:
inclusion criteria: * diagnosed with spinal cord injury, acquired brain injury and poliomyelitis survivors * at least 18 years old * consented to participate in the study exclusion criteria: * cognitive problems to understand and to respond the assessment instrument, according to medical files description and interviewer previous judgment

Keywords: acquired brain injury health-related quality of life poliomyelitis survivor rehabilitation spinal cord injury completed the whoqol-bref
anti-obesity effects of dandelion (taraxacum officinale l.)

Conditions: Obese Women; Perimenopause

Summary: the study investigates the effectiveness of the natural product dandelion in treating obesity in premenopausal women through a randomized interventional trial, measuring various parameters and biomarkers.

the study aims to explore the anti-obesity effects of dandelion supplementation in premenopausal obese women. the research will measure changes in appetite, energy intake, body weight, composition, lipid profile, and inflammatory markers, providing evidence of dandelion\&#39;s efficacy as an anti-obesity phototherapy. the randomized interventional trial will measure multiple parameters and biomarkers.

Eligibility criteria:
inclusion criteria: premenopausal women with obesity. age between 18-45 years stable body weight in the past 3 months exclusion criteria: pregnancy breastfeeding diabetes cardiovascular diseases kidney or liver diseases use of medications that affect body weight smoking allergy to dandelion or related plants

Keywords: dandelion premenopausal obese women anti-obesity
novosyn® quick versus monosyn® quick suture material in resective periodontal surgery

Conditions: Gingivitis; Gingival Diseases; Periodontal Diseases

Summary: the aim of this study is to prove that novosyn quick and monosyn quick are equivalent in early wound healing in adult patients undergoing resective periodontal surgery. in order to show equivalence between novosyn quick and monosyn quick ehs, which is composed of 3 parameters: clinical signs of reepithelization, clinical signs of haemostasis and clinical signs of inflammation, will be calculated for each suture 10 ± 5 days postoperatively and cannot differ more than 2 points. furthermore, complications, the handling of the suture material, pain, satisfaction of the patient and bacterial contamination of the thread (optional) will also be assessed as secondary objectives.


Eligibility criteria:
inclusion criteria: * adult patient undergoing resective periodontal surgery abd one of the incisions below has been performed: * crestal incision * vertical incision * intrasulcular incision * submarginal incision * written informed consent regarding the data collection for the rct exclusion criteria: * emergency surgery. * pregnancy. * breastfeeding * patients taking medication that might affect wound healing. * patients having a condition that might affect wound healing. * patients with hypersensitivity or allergy to the suture material

Keywords: resective periodontal surgery
hepatic doppler to assess venous congestion during invasive mechanical ventilation (dohecov)

Conditions: Congestion, Venous

Summary: the purpose of the study is to investigate venous congestion using hepatic vein doppler for icu patients with invasive mechanical ventilastion. the primary outcome is the systolic to diastolic hepatic vein velocity ratio s/d . the objective is to find a significant association between s/d and different congestion indicators.


Eligibility criteria:
inclusion criteria: * intubated for more than 24 hours exclusion criteria: * chronic end-stage renal disease on admission * atrial fibrillation * cirrhosis * portal thrombosis * refusal to participate * non-opposition could not be obtained from themselves or their trusted support person in the event of incapacity * under legal protection.