Kornimate/medical-research-clean huggingface dataset:
addressing mental health in african american job training adolescents and young adults

Conditions: Depression

Summary: this project's focus is twofold-to change the culture of an employment training program for adolescents and young adults (youth opportunities, or "yo") to more fully address the many mental health issues faced by its participants and to expand and improve the quantity and quality of mental health services for yo members. four project components have been carefully selected to address the mental health issues of yo members: (1) mental health education/training for yo staff and peer leaders, (2) mental health education activities for yo members, (3) mental health screening on all newly enrolling yo members, and (4) comprehensive mental health services for yo members. these project components will be implemented at the hebcac yo program (subsequently referred to as "eastside" yo), with the westside yo program initially participating as a control site. researchers at the johns hopkins university center for adolescent health, led by dr. darius tandon of the department of pediatrics, will conduct the research examining the effectiveness of these mental health services and supports. there are four project objectives. first, the proposed activities will increase yo members' knowledge of mental health resources and decrease stigma associated with seeking mental health services. second, the investigators will see an increase in yo members' receipt of needed mental health services. third, the investigators will see improvement in yo members' mental health. fourth, as a result of their improved mental health, yo members will more actively engage in yo program activities and achieve more key program milestones (e.g., ged completion). these objectives are sequential, with later objectives predicated on the achievement of earlier ones.


Eligibility criteria:
inclusion criteria: * all newly enrolling eastside and westside yo members during the study period will be eligible for study participation. exclusion criteria: * we will not enroll yo members currently in foster care in this study.

Keywords: depressive symptoms mental health services adolescents young adults african-american
nasal fentanyl and renal colic

Conditions: Acute Renal Colic

Summary: the purpose of this study is to determine whether nasal fentanyl is effective in the treatment of renal colic in adults in emergency department.


Eligibility criteria:
inclusion criteria: * the patients were adults aged 18 to 65 years, presenting in ed with classical clinical symptoms of renal colic (sudden monolateral flank pain with inguinal irradiation) with a 10-cm visual analog scale (vas) greater than or equal to 7 exclusion criteria: * were analgesia within 6 hours of arrival * allergy to opiates and nsaids * opiates abuse, known or suspected abdominal aortic dissection or aneurism, * presence of peritonitis * hemodynamic instability * pregnancy, breastfeeding, anticoagulant therapy. * patients with known renal, pulmonary, cardiac or hepatic failure, as well as those with renal transplantation, were also excluded.

Keywords: analgesia renal colic ketorolac nasal fentanyl morphine. treatment of acute renal colic
preventive effect of treatment with estradiol vaginal tablets on recurrent urinary tract infections in post-menopausal women

Conditions: Menopause; Urinary Infections

Summary: this trial is conducted in europe. the aim of this trial is to investigate the preventive effect of treatment with estradiol vaginal tablets on recurrent urinary tract infections (ruti) in post-menopausal women with signs of urogenital ageing (uga).


Eligibility criteria:
inclusion criteria: * post-menopausal woman with urogenital ageing (uga) * recurrent urinary tract infections defined as three or more urinary tract infections within the past twelve months exclusion criteria: * known or suspected allergy to trial product or related products * present uti * history of ruti during fertile period of life
outcome of operative management of posterior wall of acetabulum fracture

Conditions: Posterior Wall of Acetabulum Fracture

Summary: background: historically, acetabular fractures were treated conservatively which leading to long lasting morbidity like severe pain, limitation of movement and osteoarthritis. now, evidence suggest surgery for all acetabular fractures for better outcome. objectives: to evaluate the clinical and functional outcomes of open reduction and internal fixation of posterior wall of acetabulum fractures. methods: this prospective clinical trial was conducted at chittagong medical college hospital, chattogram, from january 2022 to february 2024. sample size was 32 with fractures as per set criteria and was treated surgically. the outcome variables were functional (according to modified merle d'aubigne and postel score) and radiological (according to matta's grading). evaluation was done at 6th weeks and at 03rd, 06th, 09th months. detailed history, clinical examination, investigations, operative details, post-operative outcome and other parameters were documented. data were collected in data collection form and were analyzed at the end of the study by using spss-25. p-value was considered as statistically significant when it was less than 0.05 and confidence interval was set at 95% level.


Eligibility criteria:
inclusion criteria: * posterior wall fracture with unstable hip joint * posterior wall fracture with posterior column or transverse fracture * incarcerated osteochondral fragment * age more than 18 years and less than 60 years * injury within 03 weeks. exclusion criteria: * open fracture * associated other acetabular fracture

Keywords: posterior wall of acetabulum, operative management
ferumoxytol-enhanced magnetic resonance imaging

Conditions: Coronary Artery Disease

Summary: there are no current alternatives to diagnostic contrast-requiring imaging for patients with an egfr \<30ml/min due to the association of gadolinium-based imaging modalities to nephrogenic systemic fibrosis and iodinated contrast-induced kidney injury. ferumoxytol-enhanced imaging may offer an alternative approach.

this is a case control study which will assess the resolution by which the coronary arteries can be visualized using ferumoxytol-enhanced cardiac magnetic resonance angiography (fcmra) in patients with prior regional cardiac ischemia localized by stress-induced echocardiography. resolution will be compared to invasive coronary arteriography completed in all patients that will be analyzed at the end of the study. masked experts will interpret fcmra images to determine if coronary stenosis is present or absent. by strict definitions, this is a single-arm study. however comparison will be made between fcmra and invasive coronary arteriography performed in each patient. with a prevalence of disease of approximately 0.35 in the study population, it is anticipated that both sensitivity and specificity of fcmra to identify the absence of coronary artery stenosis can be calculated.

Eligibility criteria:
both female and male participants are being studied aged 18-85 years old with an estimated glomerular filtration rate (egfr) of less than 30ml/min/1.73 meters squared. patients will have undergone cardiac screening tests that warrant further evaluation. patients will be excluded with an egfr \>30ml/min/1.73 meters squared. inclusion criteria: diagnosis of chronic kidney disease diagnosis of anemia of chronic kidney disease exclusion criteria: hypersensitivity to intravenous iron products
the effect of demographic, mental, and physical activity profiles towards burnout in frontline healthcare workers facing covid-19 pandemics in dr. soetomo general hospital surabaya

Conditions: Burnout, Psychological; Anxiety

Summary: this was a randomized controlled trial study to measure the effect of intervention of zumba dance towards psychological and biological markers in hospital residents managing covid-19 patients

a study to compare the effect of zumba dance exercise towards psychological and biological markers in control and intervention groups of residents managing covid-19 patients. psychological markers were assessed using state trait anxiety inventory (stai), brief resilience scale (brs), and maslach burnout inventory (mbi) questionnaires. biological markers being measured were neutrophil to lymphocyte ratio (nlr), cd4, interleukin-6 (il-6), and salivary cortisol. measurements were done at the beginning of self-isolation after shift and 2 weeks after self-isolation.

Eligibility criteria:
inclusion criteria: * residents of anesthesiology and internal medicine department at dr. soetomo general hospital surabaya * residents managing covid-19 patients in the special isolation room exclusion criteria: * residents that did not fill in the questionnaires completely * residents with comorbidities (diabetes, hypertension, heart disease or autoimmune disorders) * residents that were infected with covid-19 * residents currently or previously diagnosed with psychosis * residents refusing to participate in the study.

Keywords: mental health covid-19 healthcare workers anxiety burnout biomarkers
study of oliceridine (trv130) for the treatment of moderate to severe acute pain after abdominoplasty

Conditions: Acute Pain

Summary: the primary objective is to evaluate the analgesic efficacy of intravenous (iv) oliceridine administered as needed (prn) compared with placebo in patients with moderate to severe acute pain after abdominoplasty.


Eligibility criteria:
inclusion criteria: * has undergone abdominoplasty with no additional collateral procedures. * experiences a pain intensity rating of moderate to severe acute pain. * able to provide written informed consent before any study procedure. exclusion criteria: * asa physical status classification system classification of p3 or worse. * has surgical or post-surgical complications. * has clinically significant medical conditions or history of such conditions that may interfere with the interpretation of efficacy, safety, or tolerability data obtained in the trial, or may interfere with the absorption, distribution, metabolism, or excretion of drugs. * has previously participated in another trv130 clinical study.
the heartspare study (stage i)

Conditions: Breast Cancer

Summary: radiotherapy (rt) has a major curative role in women with early breast cancer, and is recommended routinely after lumpectomy and selectively after mastectomy. it has contributed to a halving of breast cancer mortality in the uk over the last 2 decades despite ever-rising cancer incidence. rt in women with left-sided tumours often exposes the underlying heart to a damaging dose. the heart is very sensitive to rt, and there were 1-2 deaths from heart disease for every 100 breast cancer patients treated during the 1960s-70s. the situation has improved in recent years, but standard rt techniques still deliver significant radiation doses to heart tissue. two potentially simple techniques reduce heart dose. in one, women are taught to breathe in deeply and to hold their breath for about 20 seconds while rt is given. the downward movement of the diaphragm pulls the heart away from the rt beam. in the other technique, women lie on their fronts, instead of on their backs as they normally do for breast rt. in this position, the breast falls away from the rib cage and reduces exposure of the heart. neither technique is routinely available to women receiving breast rt in the uk for reasons that this research aims to address. the investigators need to: 1) confirm that patient position can be reproduced with millimetre precision every day using these techniques, 2) minimise costs of equipment, time and personnel required to support such techniques, 3) select the most appropriate technique for different patients and 4) train staff in centres across the uk to deliver techniques safely and effectively. by addressing all of these issues, the study aims ultimately to make heart-sparing rt available to all uk women that might benefit from treatment, thereby significantly reducing the burden of heart disease in breast cancer survivors.


Eligibility criteria:
inclusion criteria: * complete microscopic excision of early stage invasive ductal or lobular carcinoma (pt1-3b n0-1 m0) of the left breast following breast conservation surgery or mastectomy. * recommendation for whole breast (groups a and b) or chest wall (group a only) radiotherapy (with or without tumour bed boost) * age ≥18 * performance status ≤1 * patients able to tolerate breath-hold exclusion criteria: * requirement for nodal irradiation * patients with micro- or macro-scopic disease on sentinel node biopsy who have not undergone completion axillary node clearance * previous radiotherapy to any region above the diaphragm
clinical performance of ars containing universal adhesives in carious cervical lesions

Conditions: Carious Lesion; Cervical Caries

Summary: evaluation of composite restorations done in carious cervical lesions restored by a conventional universal adhesive in comparison to a universal adhesive that contains and resistant silane coupling agent according to the modified united states public health service (usphs) criteria over 18 months.

the presence of acidic monomers in the bottle during storage can lead to the hydrolysis of silane contained in universal adhesives, potentially reducing its effectiveness and causing instability,the acid resistant silane coupling agent has a protective structure against attacks from acidic monomers. therefore, long-term storage stability can be expected by suppressing hydrolysis. the protective structure is removed when the concentration of acidic monomers increases by air drying after application. this activates ars, exerting the silane coupling effect.

Eligibility criteria:
inclusion criteria: * participants inclusion: • adults aging from 21-67 years old who were in need of restoration of at least one notch-shaped cervical lesion * teeth inclusion: * vital teeth with carious cervical lesions in incisors , canines ,premolars\& molars exclusion criteria: * participants exclusion: * patients with fewer than 20 teeth * poor oral hygiene * uncontrolled periodontal disease * xerostomia * known allergy to resin-based materials * medically compromised, pregnant, or breast-feeding * teeth exclusion: * non vital teeth * teeth that are out of occlusion * previously restored teeth
dynamic carbon dioxide (co2) administration for sleep apnoea

Conditions: Sleep Apnea, Central

Summary: normally breathing is controlled by a reflex that responds to the levels of carbon dioxide (co2) in the blood. in heart failure, where the heart muscle is damaged and therefore does not pump as well, this reflex is exaggerated. the result is a vicious circle: blood co2 levels fluctuate wildly and as a result breathing also fluctuates with patients hyperventilating at times and briefly stopping breathing at others. during sleep this is called central sleep apnoea (csa). patients with csa wake up throughout the night and whilst some patients are oblivious to this, others are consciously breathless and many patients are tired during the day and feel unable to perform their daily activities. as part of the body's stress response to the erratic pattern of breathing, both blood pressure and heart rate may rise to a level that is harmful in a failing heart, exacerbating the underlying heart failure. indeed patients who demonstrate this csa die sooner than those who have heart failure and stable breathing. there are no proven specific therapies for csa that stabilise breathing, improve sleep quality, and prolong life. we have designed a system which delivers very small doses of co2, when the blood level of co2 is predicted to be low. during short daytime recordings, using this system, we have demonstrated that it is possible to stabilise the body's co2 levels. we aim to test what happens when co2 is given overnight whilst the patient is sleeping to see whether we can stabilise their breathing over longer durations and whether sleep quality could be improved so that patients are less tired during the day. in addition, we would like to measure whether the stress response is lessened if the breathing is successfully stabilised.


Eligibility criteria:
inclusion criteria: * men and women 18 to 79 years of age who have new york heart association (nyha) functional class i through iv heart failure due to ischemic, hypertensive, or idiopathic dilated cardiomyopathy and whose condition had been stabilized by means of optimal medical therapy for at least one month; * an lvef of less than 40% and central sleep apnea, defined as 15 or more episodes of apnea and hypopnea per hour of sleep, more than 50 percent of which are determined to be central rather than obstructive. exclusion criteria: * pregnancy, * myocardial infarction, * unstable angina or cardiac surgery within the previous three months.

Keywords: sleep apnea periodic breathing heart failure
effect of pharmacological interventions on systolic blood pressure drops (synabpm 2 proof-of-concept)

Conditions: Syncope; Syncope, Vasovagal; Ambulatory Blood Pressure Monitoring; Antihypertensive Drugs; Orthostatic Hypotension

Summary: synabpm 2 proof-of-efficacy is a retrospective, multicentre, observational study performed in patients affected by hypotensive reflex syncope who had performed two abpms, one before and another after any therapeutical intervention aimed to increase arterial blood pressure

24-hour ambulatory blood pressure monitoring (abpm) is able to detect systolic blood pressure (sbp) drops that allow to discriminate patients with reflex syncope from controls. one episode of daytime sbp \<90 mmhg or one episode of daytime sbp \<100 mmhg, if mean 24-hour sbp is \<125 mmhg, is the best cut-off for the identification of reflex syncope patients with hypotensive susceptibility. the hypothesis of the present proof-of-concept study is that a therapeutic strategy aimed to increase arterial blood pressure can prevent sbp drops and (hopefully) reduce syncope recurrences. if the study hypothesis will be confirmed, the magnitude of increase of sbp needed to abolish sbp drops will be also assessed.

Eligibility criteria:
inclusion criteria: eligible patients were those who fulfilled all the following criteria: * had received a diagnosis of reflex syncope * had undergone an abpm as part of the routine work-up of syncope in use in these hospitals that had shown one or more daytime sbp drop \<90 mmhg or one or more daytime drops \<100 mmhg in patients with average 24-hour sbp ≥125 mmhg * had received instructions in order to abolish/reduce their antihypertensive therapy with the aim to prevent syncopal recurrences or had received active drug therapy, i.e., fludrocortisone, in order to increase their arterial blood pressure. * had performed a second abpm within 6 months from abpm 1 in order to verify the effect of the prescribed change in therapy exclusion criteria: * age \<18 years * symptomatic orthostatic hypotension (defined as a symptomatic fall in sbp ≥20 mm hg or a sbp decrease to \<90 mmhg, as per the esc guidelines; * competing causes of syncope (i.e., syncope due to arrhythmias and structural cardiac diseases and non-syncopal causes of transient loss of consciousness as defined by esc guidelines on syncope * severe structural heart disease, previous stroke or transient ischaemic attack

Keywords: syncope tilt testing carotid sinus massage 24-hour abpm
intensity, specificity and reversibility of inspiratory muscle training in asthmatics

Conditions: Asthma

Summary: inspiratory muscle training (imt) can reverse or delay the complications from the deterioration of inspiratory muscle function in asthma. thus, the imt has been considered a treatment option for people with asthma. the aim of this study is to investigate the training principles of intensity, specificity and reversibility of imt in asthmatics.


Eligibility criteria:
inclusion criteria: * diagnosis of asthma * adults (18 - 60 years) exclusion criteria: * inability to perform the protocol established by the study * others respiratory diseases * request for study withdrawal
morphological predictors of sudden cardiac death in patients with known cardiomyopathies

Conditions: Cardiomyopathy

Summary: this is a pilot study to find a correlation between mri and icd therapy in patients with known cardiomyopathies, aiming to determine if cardiac scarring identified by mri correlates with ventricular arrhythmias and the occurrence of icd therapy.

this is an observational study over a 3 year period of 50 patients with known cardiomyopathy and lvef of 35% or less who will have icd implantation as part of their standard of care. all subjects will undergo a contrast-enhanced cardiac mri using gadolinium to determine the morphological characteristics of their left ventricle prior to icd implant. subjects will not be offered sedation to minimize risk, thus those suffering from claustrophobia will be excluded or dropped from participation. mri will be evaluated, and subjects will be followed during standard of care device interrogations for 12 months after implant.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * cardiomyopathy with lvef 35% or less * indication for icd implantation * able to provide informed consent exclusion criteria: * prior device implantation * contraindication for mri (i.e., metallic foreign body) * claustrophobia * pregnant women

Keywords: icd implantation cardiac mri cardiomyopathy ventricular arrhythmias lvef 35% or less indication for icd implantation as part of standard of care
ivf/icsi protocols in poor responders with growth hormone

Conditions: Female Infertility Due to Diminished Ovarian Reserve

Summary: in this study, we are trying to monitor the effect of the addition of growth hormone on the different down regulation protocols ( long, short, antagonist and microflare). the outcome will be primarily assessed by the clinical pregnancy rates.

poor responders undergoing ivf/icsi cycles have emerged as a major problem. the need to find a proper stimulation protocol is a must. in this study we are trying to detect the best stimulation protocol ,in addition to growth hormone ,that can give the highest pregnancy rates in these patients.

Eligibility criteria:
inclusion criteria: eshre consensus 2011,at least two of the following three features must be present: * advanced maternal age (≥40 years) or any other risk factor for por; * a previous por (≤3 oocytes with a conventional stimulation protocol); * an abnormal ovarian reserve test (i.e. afc \< 5-7 follicles or amh \< 0.5 -1.1 ng/ml). exclusion criteria: * female patients with causes of infertility other than poor ovarian reserve * females suffering from congenital or acquired uterine anomalies * females with focal uterine lesions * females who had previous ovarian surgeries * females with history of previous exposure to radiotherapy , or chemotherapy * females refusing to get enrolled in the study

Keywords: poor ovarian response poor responders ivf/icsi growth hormone