Kornimate/medical-research-clean huggingface dataset:
effectiveness of hvni in preterm infants with moderate respiratory distress

Conditions: Respiratory Distress, Newborn

Summary: neonatal respiratory distress is a common problem in preterm infants. the application of cpap is widely used in neonatal units as a primary mode of respiratory support for respiratory distress. however, discomfort, nasal injuries, and fixation difficulties have been reported as obstacles when applying cpap. high velocity nasal insufflation (hvni) may serve as an alternative to cpap. trials are needed to evaluate the effectiveness of hvni in reducing the incidence of respiratory distress. the aim of this study is to compare the clinical effectiveness and safety of hvni as an alternative therapy to cpap in premature infants with moderate respiratory distress. this study is a prospective, non-inferiority, randomized, unblinded controlled trial to compare the efficacy of hvni and cpap. the subjects were randomly allocated to receive either hvni or cpap according to the study protocol. they were randomly assigned using blocks of four. the completion of hvni therapy was determined by therapeutic failure within 72 hours following enrollment, indicated by the need for intubation.


Eligibility criteria:
\*\*inclusion criteria:\*\* * preterm infants born in cipto mangunkusumo hospital with gestational age (ga) less than 32 weeks or birth weight less than 1500 grams. * infants with moderate respiratory distress (downe score ≤ 6) detected within 24 hours after birth. * parents are willing to participate in the study. \*\*exclusion criteria:\*\* * infants with severe respiratory distress (downe score ≥ 6) requiring invasive treatment in the form of mechanical ventilation, or apnea indicated by surfactant administration via endotracheal tube. * infants with contraindications to the use of non-invasive ventilation such as esophageal atresia, diaphragmatic hernia, air leak syndrome, and other conditions. * infants with respiratory distress due to non-pulmonary abnormalities. * infants with congenital metabolic disorders. * infants with congenital abnormalities that exacerbate respiratory distress.
effects of onion peel extract on endothelial function

Conditions: Healthy; Overweight; Obese

Summary: acute or chronic intake of polyphenol-rich foods has been reported to improve endothelial function. quercetin, found abundantly in onion, is a potent antioxidant flavonoid. this study was designed to investigate whether consumption of onion peel extract (ope) improves endothelial function in healthy overweight and obese subjects.

epidemiological studies have shown a rapid increase in the prevalence of overweight and obesity, not only in adults but also in children and adolescents, thus increasing the risk of early development of cardiovascular disease (cvd). quercetin, found abundantly in onion, prevents the induction of endothelial dysfunction, superoxide production, and overexpression by angiotensin ii in the rat aorta. furthermore, in our previous study we showed that supplementation with quercetin-rich onion peel extract (ope) influenced adipokine expression, thus addressing its modulatory effect on obesity-induced inflammation, and improved insulin resistance by alleviating the metabolic dysregulation of free fatty acids, suppressing oxidative stress, upregulating glucose uptake, and downregulating inflammatory gene expression. but there are limited studies on the relationship between quercetin supplementation and endothelial dysfunction in humans.

Eligibility criteria:
inclusion criteria: * age 20 to 60 years * bmi \>23 kg/m2 * abdominal circumference \> 90 cm in males or \>85 cm in females exclusion criteria: * hypertension (\>140/90 mmhg), * diabetes * any cardiovascular disease, * kidney disease, * thyroid disease * cerebrovascular disease * liver disease (bilirubin level \>2 mg/dl) * pregnancy

Keywords: quercetin endothelial function onion peel extract volunteers
zenapro™ hybrid hernia repair device for ventral hernia repair

Conditions: Ventral Hernias

Summary: the objective this study is to collect post-market data on the performance of the zenapro™ hybrid hernia repair device when used to reinforce or bridge the abdominal wall for the repair of ventral hernias.


Eligibility criteria:
inclusion criteria: * primary or recurrent ventral hernia * need for abdominal wall repair with reinforcement or bridging material to obtain the desired surgical result exclusion criteria: * age \< 21 (i.e., infants, children) * device intended to be used in an infected wound * known sensitivity to porcine material * pregnant or planning pregnancy in the future * life expectancy of less than 12 months from the date of the index procedure * hernia too large to be covered with a single device with at least 4-5 cm of tissue overlap on all sides

Keywords: ventral hernia graft repair
perinatal outcomes in patients with elevated sflt-1/plgf ratio

Conditions: Hypertension in Pregnancy

Summary: retrospective cohort study that evaluated 190 subjects admitted with diagnosis of hypertensive disorder of pregnancy, between 24 and 36 6/7 weeks, with an sflt-1/plgf index greater than or equal to 110. data were collected on their clinical course prior to termination of pregnancy, using the last reported sflt-1/plgf ratio value to classify the population into four cohorts: values between 110-205, between 206 and 654, between 655 and 999 and greater than 1000.


Eligibility criteria:
inclusion criteria: * diagnosis of hypertensive disorder of pregnancy * gestational age between 24 - 36 6/7 * sflt-1/plgf \> 110 exclusion criteria: * gestational age below 23 6/7 weeks and above 37 weeks at the moment of admission. * absence of sflt-1/plgf ratio result.

Keywords: hypertension, pregnancy induced angiogenic factors
fibromyalgia during the covid-19 pandemic

Conditions: Fibromyalgia, Primary

Summary: on 12 january 2020, the world health organization (who) confirmed that a novel coronavirus was the cause of a respiratory illness in a cluster of people in wuhan city, hubei province, china, which was reported to the who on 31 december 2019. there is evidence of a high prevalence of psychiatric comorbidities in fibromyalgia (fm )(especially depression, anxiety, post-traumatic stress disorder), which are associated with a worse clinical profile. in these challenging times of covid-19, anxiety increased among the general population. fibromyalgia patients are more at risk of developing anxiety in these difficult times. this might result in more frequent visits to the rheumatology clinics with an exacerbation of their chronic pain syndrome.

the first confirmed case relating to the covid-19 pandemic in the united arab emirates was announced on 29 january 2020. on march 11, the world health organization (who) declared the global outbreak a pandemic. many measures have been taken by the uae government since the covid-19 outbreak started hitting the region. from mid march, the uae had advised all citizens to restrict themselves to essential travel only and had implemented a curfew between 8 pm and 6 am every day starting from the end of march. on april 5th, uae imposed a two-week lockdown to contain the covid-19 pandemic and announced there will be disinfection drives. many awareness campaigns were initiated by rheumatologists through different media channels advising patients with rheumatic diseases to avoid clinics and hospitals unless they have an emergency. some healthcare facilities started telemedicine services including rheumatology outpatient clinics. however, most of the clinics and hospitals have maintained open rheumatology clinics aiming to manage emergency cases. fibromyalgia (fm) is a chronic disorder characterized by widespread and chronic musculoskeletal pain and other frequent syndromes such as chronic fatigue sleep disturbance, cognitive impairment, irritable bowel disease, depression, and anxiety. there is evidence of a high prevalence of psychiatric comorbidities in fm (especially depression, anxiety, post-traumatic stress disorder), which are associated with a worse clinical profile. in these challenging times of covid-19, anxiety increased among the general population. fibromyalgia patients are more at risk of developing anxiety in these difficult times. this might result in more frequent visits to the rheumatology clinics with an exacerbation of their chronic pain syndrome.

Eligibility criteria:
inclusion criteria: * patients aged \> 18 year * diagnosis of primary fibromyalgia * newly diagnosed and follow up patients are included * patients who have physically attended the rheumatology clinic during the study period. exclusion criteria: * patients aged \< 18-year-old * patients with inflammatory arthritis and associated fm (secondary fm) * patients who didn't physically attend the rheumatology clinics (those who used phone calls and other telemedicine platforms).
position of children during urine collection: evaluation study

Conditions: Urinary Infection

Summary: urinary tract infection (uti) is a frequently suspected cause of fever in young children, justifying urine cultures. sampling procedures are decisive for the reliability of uti diagnosis. even though official guidelines recommend clean catch method, catheterization or suprapubic aspiration, urine bag collection remains widely used. in our experience, the rate of contaminated bag-obtained cultures reaches 30.2 %. in a recent study, the investigators have noticed that the rate of contaminated urine cultures was lower when children were kept in an upright position at the time of urine collection. the upright position could explain this decrease, perineum being less in contact with urine. these results are borderline significant, the investigators would like to confirm them with a specific study.


Eligibility criteria:
inclusion criteria: * children aged 2 - 36 months * non-toilet-trained children * indication to bag urine collection with the following criteria : * fever ≥ 38.5 °c * unexplained fever * and at least 1 of the following criteria for girls and uncircumcised boys, at least 2 criteria for circumcised boys : * age ≤ 12 months * fever ≥ 48 hours * poorly tolerated fever (chills ± cyanosis ± pronounced weakness...) * preceding episode of tract urine infection exclusion criteria: * parents opposed to the participation of their children in the study * diarrhea * current antibiotic treatment or during the 8 preceding days of the urine collection * genitals / perineal anomaly

Keywords: paediatrics urinary tract infection urine collection
a prospective study to compare the clinical outcomes, pain and patient quality of life for hernia patients

Conditions: Hernia; Incisional Hernia; Hernia, Inguinal, Indirect; Hernia, Inguinal, Direct; Inguinal Hernia

Summary: the objective of this prospective, multi-center post-market study is to prospectively collect uniform, evidence based outcomes for patients undergoing open, laparoscopic or robotic assisted hernia repair. the outcomes that will be collected include various routine clinical parameters, short term patient reported outcomes (quality of life, pain scores) and long term hernia recurrence information. patients will be treated according to standard of care at the surgeon's institution and patients will be followed up to collect information related to complications information and patient satisfaction associated with the hernia repair procedure.


Eligibility criteria:
inclusion criteria: 1. age 18 years and older 2. all patients undergoing either an open, laparoscopic or robotic-assisted 3. incisional or inguinal hernia repair procedure 4. non-emergent incisional or inguinal hernia repair cases exclusion criteria: 1. emergent cases for both incisional and inguinal hernia 2. incisional hernia related to ostomy formation 3. incisional hernia requiring component separation (determined pre-operatively or intraoperatively)
evaluation of immunochromatographic tests for campylobacter detection in stools

Conditions: Gastroenteritis

Summary: for a long time, culture was the only way to detect campylobacter. it appears that rapid immunochromatographic tests (ict) have detected more positive cases compared to culture, elisa and molecular tests. the aim of our study is to evaluate the specificity of the ict which are really interesting tools to use since they allow a diagnosis in about 15 min, in comparison to different methods of detection even serology.

all of the patients coming to an emergency care unit and for whom a stool culture is prescribed will be included, corresponding to an estimate number of 1,000 patients for two years. every stools will be tested for campylobacter using two different ict tests in addition to the standard culture. then, in function of the ict test result : 1) in case of negative result, no other campylobacter detection will be performed except the standard culture, 2) in case of positive result, stools will be tested for campylobacter by two elisa tests, one pcr and a serology at two different times (d0 and d15) will be performed. around 70 patients should be detected positive with icts, according to precedent studies. the 70 patients detected positive with at least one of the two ict will have a serology control 15 days after the ict test. the reference test will be the combination of culture result, evolution of the serology between d0 and d15 and the pcr and elisa results. we want to define a procedure to follow in order to detect as soon as possible and with the best results, the campylobacters in the stool of patients. this has the aim of being able to manage patients who need appropriate antibiotic treatment, and also to reduce the time of hospitalization of patients quickly detected as suffering from a campylobacter infection.

Eligibility criteria:
inclusion criteria: * any patient of any age (pediatric and adult) and any sex * admitted to the emergency hospital for less than 48 who had a stool sample for stool culture including women and elderly patients over 65 years exclusion criteria: * there is no " non-inclusion " criteria

Keywords: campylobacter diagnosis, immuno-chromatographic test, elisa, pcr, culture, stool elisa, pcr, culture, stool
3d analysis of the effects of tdcs (transcranial direct current stimulation) on a functional task in high level athletes

Conditions: Healthy; Athlete

Summary: relatively high level athletes will undergo 2 randomized, cross-over counterbalanced sessions of bi-anodal tdcs (transcranial direct current stimulation) or sham tdcs the primary outcome is a 3d evaluation coupled with emg (electromyography) of their primary lower limb muscles after each session

recruitment : relatively high level athletes will be recruited through social media and advertisements. each subject came twice to the liege university hospitals' human movement analysis laboratory. after placing the different infrared emitters and placing and calibrating the surface emg electrodes, subjects underwent 3 maximal squat jumps (without upper limb implication). they were then familiarized with the fatigue protocol (8 jumps at a 33 jumps per minute pace). then each subject received either bi-anodal tdcs of sham tdcs. neither the evaluator or the subject knew which they were receiving. immediately following tdcs, subjects underwent another warmup 3 maximal squat jumps, and then the fatigue protocol (comprised of 30 maximal jumps at a rate of 33 per minute).

Eligibility criteria:
inclusion criteria: * at least 10 hours of sport a week * right handed and footed exclusion criteria: * one on the tsst (in high and relatively high risk sections) * previous neurological or orthopedic pathologies affecting limbs

Keywords: tdcs athlete endurance fatigue 3d
remifentanil as intravenous patient-controlled analgesia (ivpca) during labour

Conditions: Labour Pain; Satisfaction; Adverse Effects

Summary: remifentanil is a ultra short-acting synthetic opioid. it is rapidly metabolized by non-specific blood and tissue esterases. we wanted to investigate the efficacy and safety of remifentanil used as analgesia during labour. intravenous patient controlled analgesia (ivpca) were used to administer remifentanil. doses used were 0,15-1,05 mikrogr/kg, with a lock-out time of 2 minutes. 41 women were included in the study. blood-pressure, heartrate, sao2, respiration rate and sedation were recorded every 15.minute. fetal heart rate was recorded for the whole periode of treatment (ctg, stan). vaginal contraction pain were assessed by the parturients every 15.minute using a visual analogue scale (vas). midwives also recorded their impression of the parturients pain. the parturients level of sedation were recorded by anesthesiologist and midwife every 15.minute. apgar scores were registered at 1, 5 and 10 min after delivery. umbilical cord blood analysis regarding blood gases and concentration of remifentanil were performed. after delivery, both mother and midwife evaluated efficacy and safety; global satisfaction score, if the remifentanil doses were sufficient, nausea, vomiting, level of sedation and dizziness.

primary and secondary outcome measures presented under "results"

Eligibility criteria:
inclusion criteria: healthy women (asa i-ii), in active labour, one fetus with no suspected pathology, expecting normal childbirth, informed consent. exclusion criteria: failure to obtain informed consent, received opioids within last 8 hours before study start, serious side-effects mother and abnormal fetal heart rate.

Keywords: remifentanil, parenteral opioids, obstetric analgesia, ivpca
taes improve the function of respiration and circulation on elderly patients undergoing colonoscopy procedure

Conditions: Respiratory Depression

Summary: to explore the effectiveness of transcutaneous acupuncture electrical stimulation (taes), a non-invasive modality in improvement of the function of respiration and circulation on elder patient during colonoscopy.

to assess the function of respiratory and circulation before precondition, during colonoscopy and end of the procedure, blood cortisol and catecholamine levels were measured also.the incidence of airway support, application of vasoactive drug or atropine during procedure were recorded in the meantime.

Eligibility criteria:
inclusion criteria: 1. patients aged 65 or older 2. american society of anesthesiologists (asa) grade i\~ii 3. consent and voluntary participation in this experiment 4. patients under colonoscopy 5. none allergic to propofol and fentanyl 6. airway assessment for none difficult airway exclusion criteria: 1. allergic to propofol, fentanyl. 2. asa is greater than or equal to grade 3 3. abnormal respiratory tract may cause severe respiratory obstruction 4. unsatisfactory control of hypertension, systolic pressure over 160 millimeter of mercury (mmhg) or diastolic pressure over 100 mmhg 5. hypotension, systolic pressure below 90 mmhg, heart rate (hr) \ 100bpm
indicators for clarifying the background of extreme obesity in children

Conditions: Gene Abnormality; Child Obesity; Hunger

Summary: the study investigates the genetic backgrounds of extreme childhood obesity (using saliva sample) and contains short online questionnaires on family history, phenotypical characteristics and hunger behavior. it is an observational study in a predefined cohort (subjects with data in crescnet aged 0-18 with bmi measurement(s) above the 99.5th percentile). recruitment will initially be from crescnet data through the cooperating pediatric and adolescent medical institutions associated with these initiative of data collection in germany.

in order to be able to investigate the genetic background of extreme obesity, current bmi developments above the 99.5 bmi percentile (extreme obesity) are selected in the existing crescnet register. pediatricians (submitting the data) will be informed about these cases. they will be ask to re-identify the patient using the pseudonym (crescnet-id) maintained in the registry and to contact the family with a request to participate in the study. the study physician of the study center at the leipzig university hospital will take over the study inclusion as well as all necessary clarifications and consents for the study and the genetic examination contained therein. since the potential probands may live anywhere in germany, telemedical contact between the study center and the family (interested in participation) will be used. in addition to the above-mentioned study inclusion, the study physician is also responsible for instructing the family on the correct drawing, collection and sending of saliva samples to the study center, as well as instructing them on how to complete the hyperphagia questionnaire. at this appointment, the proband is assigned an internal study identification number (indicator-id). saliva sample and all questionnaires are assigned to this number.

Eligibility criteria:
inclusion criteria: * test subjects older 5 years: bmi sds between 0-5 years \> 1.881 (= p97) bmi sds between 5 and 18 \>2.567 (=p99.5) parents and subjects agree that the study information will be provided during a telemedical consultation by the study physician exclusion criteria: * known cause of servere early obesity
young-onset colorectal cancer screening based on artificial intelligence

Conditions: Colorectal Cancer

Summary: in this study, we aimed to develop, internally and temporally validate the machine learning models to help screen yocrc bansed on the retrospective extracted electronic medical records (emr) data.

diagnosis of young-onset colorectal cancer (yocrc) has become more common in recent decades. screening crc among younger adults still remains a challenge. in this study, we plan to retrospectively extracte the relevant clinical data of young individuals who underwent colonoscopy from 2013 to 2022 using electronic medical record (emr). multiple supervised machine learning techniques will be applied to distinguish yocrc and non-yocrc individuals, the above classifiers will be trained and internally validated in the training dataset and internal validation dataset admitted between 2013 and 2021, respectively. we will also assess the temporal external validity of the classifiers based on the admissions from 2022.

Eligibility criteria:
inclusion criteria: * newly diagnosed with crc (yocrc group) * age at 18-49 when diagnosis (yocrc group) * never received any crc-related treatment (yocrc group) * no crc confirmed by colonoscopy or pathology (non-yocrc group) * age at 18-49 (non-yocrc group) exclusion criteria: * hospital stay less than 24 hours or with incomplete complete blood count * patients with inflammatory bowel disease or hereditary crc syndromes * history of other types of primary malignant tumor and other reasons that made them unsuitable for enrollment

Keywords: young-onset colorectal cancer cancer screening artificial intelligence machine learning