Kornimate/medical-research-clean huggingface dataset:
the effect of eccentric training on anthropometrics, physical fitness and bone strength in overweight children

Conditions: Childhood Obesity

Summary: the purpose of this study is to examine the effects of aerobic eccentric training in overweight and obese children.

recent studies have shown that similarly to regular exercise, aerobic eccentric contraction (ecc) exercise induces changes in the musculoskeletal system while using lower energy consumption, due to the fact that eccentric training creates greater force in the muscle. most of the studies in this subject were done on healthy or overweight adults. therefore, the effect of aerobic eccentric training on children is still unknown. this study wants to test the impact of eccentric training on overweight and obese children. this study will include approximately 100 overweight and obese children (boys and girls), aged 5-18 years. participants will be recruited from the population of overweight children from children sports medical center 'meir' in kfar saba, israel. participants will be randomly divided into two groups (intervention and control). participants and their parents will sign a consent form before entering the study. each participant will undergo a series of tests including: anthropometrics (height, weight, bmi, body composition by bia), fitness tests (maximal distance achieved in a 12min outdoor run\\walk, vertical jump, standing long jump, 4x10 meter sprint run), quadriceps and hamstrings strength test (hand-held dynamometer microfet2), bone strength (bone sonometer), ankle and tibial kinematic(accelerometers+ video of foot strike). intervention group will then perform an 8 week (16 sessions) ecc training program on a decline treadmill, the program will include two weeks of habituation to lower as possible doms (delayed onset muscle soreness) and possible injuries, training length and intensity will be gradually increasing over the time of the program, maximal negative gradient will be -15% at the end of the program. control group will perform the same amount of training (volume, intensity and frequency) on a neutral gradient surface. after completing the training program each participant will perform again the series of tests. once all the data is collected, statistical test will be performed in order to learn about the effect of ecc training program on overweight and obese children.

Eligibility criteria:
inclusion criteria: * children and adolescents aged 5-18. * children and adolescents with overweight defined as bmi percentile over 85%. * children and adolescents who are able to perform moderate physical activity. * children and adolescents that participate in 'meir' hospital sports and health centre. exclusion criteria: * participant that does not wish to participate - will not be obligated to do so, and shall not participate in the study. * participants with orthopaedic history in the past two years.

Keywords: eccentric training childhood obesity decline treadmill
treatment outcome using vivaer stylus to treat nasal airway obstruction

Conditions: Nasal Obstruction

Summary: this study evaluates subjective and objective measures of treatment outcome after using the aerin medical vivaer™ stylus to treat nasal obstruction

this is a non-significant risk, prospective, non-randomized study to evaluate subjective and objective measures of nasal obstruction both before and after treatment with the vivaer stylus. the stylus is used to deliver radiofrequency (rf) energy to the nasal valve area to improve symptoms in those diagnosed with nasal airway obstruction.

Eligibility criteria:
inclusion criteria: * complaints of nasal obstruction for at least 1 year * failed maximum medical therapy (4-6 weeks of steroids) * nasal obstruction symptom evaluation (nose) score of ≥ 60 at baseline * nasal valve is a primary or significant contributor to the subject's nasal obstruction as determined by the study investigator (based on clinical presentation, physical examination, nasal endoscopy, etc.) and the subject has a positive response to any of the following temporary measures (based on patient history or during office exam): 1. use of external nasal dilator strips (e.g., breathe right strips) 2. q-tip test (manual intranasal lateralization) 3. use of nasal stents 4. cottle maneuver (manual lateral retraction of the cheek) exclusion criteria: * prior surgical treatment of the nasal valve * rhinoplasty, septoplasty, inferior turbinate reduction or other surgical nasal procedures within the past three (3) months * severe and/or chronic sinusitis, recurrent sinusitis, or allergies leading to nasal obstruction and currently requiring oral corticosteroid therapy * severe case of any of the following: septal deviation, turbinate hypertrophy, polyps, or ptotic nose tip believed to be the primary contributor to the subject's nasal obstruction symptoms and warranting surgical intervention * known or suspected allergies or contraindications to the anesthetic agents and/or antibiotic medications to be used during the study procedure session * known or suspected to be pregnant, or is lactating * other medical conditions which in the opinion of the investigator could predispose the subject to poor wound healing or increased surgical risk

Keywords: nasal valve nasal airway obstruction
multi-center trial to evaluate an internal joint stabilizer - elbow

Conditions: Trauma; Chronic Elbow Dislocation

Summary: the purpose of this study is to confirm the safety and effectiveness of the internal joint stabilizer - elbow.


Eligibility criteria:
inclusion criteria: * the subject is \>21 years of age. * the subject is considered a candidate for the internal joint stabilizer -elbow (ijs-e) under one of the following indications: * subjects where either the elbow sublocates or dislocates after repairing the injured ligaments and/or bones * the elbow has been subluxated or dislocated for more than 10 days prior to surgery * the elbow subluxes or dislocates after surgical repair/reconstruction * the subject has sufficient quantity or quality of bone. specifically there is sufficient trochlea of the distal humerus and of sufficient quality that the axis pin of the ijs-e has a secure hold as judged by the surgeon intra-operatively. also, the screws placed in the ulna must be judged by the surgeon to have sufficient hold. * the subject or legal guardian has been informed of the nature of the study, agrees to its provisions, and has provided informed written consent. * the subject is willing to be available for the appropriate follow-up for the duration of the study. exclusion criteria: * the subject has one of the following conditions: * presents with limited elbow motion as opposed to instability (subjects where instability is created through surgical release for chronic limitation of movement, soft tissue release, removal of adhesions and heterotopic ossification and/or fascial interposition will be excluded). * active infection, suspicion of colonization or quiescent infection * bacteremia * bone loss greater than 30% of the total articulation or involving an entire column of the distal humerus * the subject has less than 50% of the height of the coronoid remaining, based on lateral x-ray view * osteoporosis to the degree that the screws that insert into the ulna loosen during implantation * material sensitivity to titanium or cobalt chrome * the subject has imminent, known issues related to life expectancy. * the subject is unable and/or unwilling to cooperate with study procedures, a rehabilitative program, or required follow-up visits. * the subject has a condition that may interfere with the outcome or impede healing. * the subject, in the opinion of the clinical investigator, has an existing condition that indicates he/she is not a good candidate for the study. * the subject is unable or unwilling to give informed consent and/or who has no responsible family member willing to give consent. * the subject is transient and has no fixed address. * the subject is a prisoner. * the subject is \ 21 years of age but skeletally immature.
clinical performance of therapeutic use of btx for bruxism

Conditions: Myofascial Pain Syndrome; Myofascial Trigger Point Pain; Bruxism; Pain

Summary: the goal of this clinical trial is to learn about the performance of botulinum toxin (btx) injections for bruxism. participants were divided into two groups according to the duration of the symptoms. the main question is whether btx should be reserved for long-standing bruxism where the conventional methods failed or indicated as a first-line treatment. the investigator also compared the required doses and the frequency of treatment sessions between these two groups for a complete recovery.

the effectiveness of botulinum toxin (btx) in treating bruxism is recognized and well-established. this study aims to provide the most suitable condition for a better performance of btx injections. this retrospective study of a single-arm trial was conducted using a medical database of 67 patients who suffered from bruxism between 2009 and 2015, and who had total recovery after injection sessions. patients were divided into two groups based on the duration of their bruxism. the main outcomes measured were: pain relief, the total number of injection sessions until total recovery, doses of btx used, and recovery duration between two consecutive sessions. the treatment was stopped when bruxism disappeared. the investigator carried out injections using dysport (ipsen pharma, germany). the toxin was reconstituted with 0.9% sodium chloride solution so that 0.1 ml corresponded to 25 u. the patient received the same doses in each session, delivered to trigger points (trps). 0.05 ml was injected into each trp. the level of statistical significance was set at p \< 0,01. the chi-square test and anova table were used to compare differences according to injection sessions, doses of btx, trps, and recovery duration between the two groups (with long-standing bruxism, and recent bruxism).

Eligibility criteria:
inclusion criteria: * patients who self-reported having awake bruxism and recovered completely following btx injections during the period ranging between 2009 and 2015. it includes patients who had previously occlusal splints and who should stop their use once the btx injections were started. exclusion criteria: * patients suffering from temporomandibular disorders or having a contraindication to btx injection.

Keywords: botulinum toxin treatment bruxism myofascial pain syndrome
tissue-engineered construct based on buccal mucosa cells and matrix from collagen and polylactoglycolide fibers

Conditions: Urethral Stricture

Summary: this study investigates safety and efficacy of surgical treatment of patients with anterior urethral stricture using a tissue-engineered construct based on autologous buccal mucosa cells and matrix from reconstituted collagen and reinforcing polylactoglycolide fibers. this is a single arm study with no control. success will be assessed via objective and subjective methods; complications will be tallied in a standardized fashion. outcomes will be measured at five years.

treatment of urethral strictures longer than 2 cm is an actual clinical challenge. in this case, the common method is replacement surgery using a buccal mucosa graft. however, the main disadvantage of this method is associated with limited donor resources and donor site morbidity. the aim of this study is to assess safety and efficacy of surgical treatment of patients with anterior urethral stricture using a tissue-engineered construct. the construct consists of autologous buccal mucosa cells and matrix from reconstituted collagen and reinforcing polylactoglycolide fibers. patients will be followed up for 5 years within this study. the follow-up regimen includes retrograde and pericatheter urethrography, voiding cystourethrography, uroflowmetry, biopsy, and quality of life monitoring. telephone follow-up will take place in between these assessments. the data obtained from this study will have practical implications for the urethral stricture treatment and will be based on the principles of evidence-based medicine.

Eligibility criteria:
inclusion criteria: * patient signed informed consent form * diagnosed anterior urethral stricture longer than 2.0 cm and shorter than 4.0 cm * at least one prior internal optical urethrotomy and/or urethral bougienage non-inclusion criteria: * acute infectious diseases * patient with decompensated heart and renal failure * patient with non-compensated diabetes mellitus * patient with malignant tumor * patient with polyvalent allergy * mental disorders * post traumatic urethral strictures * subtotal and total urethral strictures * sexually transmitted infections * hypersensitivity to any components of tissue-engineered constructs * any clinical state which does not ensure the safe implementation of study procedure (investigator's view) * other associated urethral strictures * laboratory markers of active urethritis exclusion criteria: * patient's refusal from the further participation in trial * confirmed syphilis, hiv, hepatitis b or c infections * patient who cannot be regularly examined due to any circumstances

Keywords: autologous cells buccal mucosa urethroplasty tissue-engineered construct hybrid matrix collagen polylactoglycolide fibers
woman mental health and addictions on pregnancy

Conditions: Pregnancy; Mental Disorder; Substance Abuse

Summary: the study intend to achieve the following objectives objective 1: develop a collaborative infrastructure among different hospital services to support research that improves the accessibility, quality, and outcomes of integrated mental health services for pregnant women for tobacco, benzodiazepine, and other substance use and/or mental health problems. objective 2: to evaluate the effect and test the application of computer/smart phone based tools that can assist in the goal of achieving broader effect, improved accessibility and outcomes of substance abuse/mental health services in at-risk populations. objective 3: conduct research on mental health services that: (a) emphasize rapid screening and referral; (b) test the feasibility, acceptability, and effectiveness of two different comprehensive behavioral treatment approaches (standardized clinical intervention and smart phone/computer-based intervention) for pregnant women with tobacco, benzodiazepine, and other substance use problems and mental health disorders; and (c) measure and decrease the obstetric, pediatric, and mental health consequences of these problems on the mother and child. to achieve these objectives, investigators propose a system of evaluation and recruitment of patients in five gynecology departments that annually attend 3700 deliveries. a telematic intervention system based on a platform that we have used for other studies (memind) and finally a randomized blinded clinical trial of 3 branches with 100 patients per branch (usual treatment, telematic intervention and standardized clinical intervention).


Eligibility criteria:
inclusion criteria: 1. two or more positive responses to the ac-ok-mental health (ac-ok mh)subscale and 2. one or more positive responses to the ac-ok-substance abuse (ac-ok sa) subscale and/or reported smoking more than once a month and 3. no use of specialized services, defined as not having an appointment in the following month and have not seen a clinician in the past three months and 4. if the paykel suicide scale was administered, they answered no to questions 4 and 5. exclusion criteria: 1. had received a diagnosis of psychotic or bipolar-related disorders or 2. lacked capacity to consent, as determined by not being able to answer questions of the study purpose or process.

Keywords: mental health substance abuse smoking dual disorders pregnancy
trial of iressa in prostate cancer patients

Conditions: Prostate Cancer

Summary: this study is being carried out to see if zd1839 is effective in treating prostate cancer after being diagnosed with an early rising psa (prostate specific antigen) following surgery.


Eligibility criteria:
inclusion criteria: * removal of prostate for prostate cancer * raised level of prostate specific antigen (psa) post-surgery * can have received some radiation therapy exclusion criteria: * any after surgery male hormone blocking therapy. * low white blood cell count * abnormal liver function test
study of ocv-501 in patients with acute myeloid leukemia (aml) (extension from study 311-10-001)

Conditions: Acute Myeloid Leukemia

Summary: the purpose of this study is to assess the safety of ocv-501 in patients with aml who completed the study 311-10-001 and were judged that there was no relapse by any inspections in the end of the study.


Eligibility criteria:
inclusion criteria: * patients who completed the study 311-10-001 and were judged that there was no relapse by any inspections in the end of the study. * patients who are capable of giving informed consent exclusion criteria: * patients failed to discontinue the study 311-10-001 even though patients met the discontinuation criteria. * patients who have participated in any other clinical trials , excluding the study 311-10-001).

Keywords: acute myeloid leukemia wt1
the use of the hem-o-lok clip in appendectomy: single or double?

Conditions: Acute Appendicitis

Summary: stump safety is provided by different methods in laparoscopic appendectomy. stapler use, binding with endoloop and nonabsorbable clip are the most common methods. although the stapler is safe, it creates a significant cost increase. in connecting with the endoloop, the learning curve and surgical time are longer. nonabsorbable clip application which has been used recently; urethra was also used in appendectomy after its safety has been proven by large studies to close cystic ducts and vascular structures. its advantages such as low cost, no need for a learning curve and shortening the surgical time have increased the frequency of use.in this prospective observational study; it will be aimed to investigate the effects of stump closure methods applied in laparoscopic appendectomy on short-term clinical results. in addition, the factors that determine the surgeon's stump closure method and cost results will be tried to be determined.

detailed explanation will be made later if necessary.

Eligibility criteria:
inclusion criteria * diagnosis of acute appendicitis * performing laparoscopic surgery * patients with an asa score of i-ii-iii exclusion criteria: * appendectomies with the patient's refusal to participate in the study * open surgery * primary pathology without appendicitis

Keywords: laparoscopic appendectomy hem-o-lok clip stump closure
obinutuzumab in treatment of fibrillary glomerulonephritis

Conditions: Fibrillary Glomerulonephritis

Summary: the purpose of this research is to learn if obinutuzumab is effective and safe in treating patients with fibrillary glomerulonephritis (fgn).


Eligibility criteria:
inclusion criteria: * ≥18 years of age * biopsy proven fibrillary glomerulonephritis * proteinuria \> 1.0 g/24hrs prior to initiation of immunosuppressive therapy * egfr ≥ 20 ml/min/bsa exclusion criteria: * secondary fgn (due to monoclonal gammopathy, autoimmune disease or malignancy) * presence of a secondary pathology on biopsy (e.g. diabetic nephropathy) * hepatitis b, c or hiv positive * pregnant or breast-feeding * active infection * kidney transplant * anemia with hgb \< 8.0 g/dl * thrombocytopenia with platelet count \< 100'000 * any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or render the patient at high risk from treatment complication * patients who have received cyclophosphamide in the last 6 months * patients who have received acth and/or mycophenolate mofetil in the last 30 days * patient who are on prednisone therapy at a dose \> 10 mg/day in the last 15 days * patients who received rituximab previously with cd20 count of \< 5 cells/microliter at the time of enrollment * for women who are not postmenopausal (greater than or equal to \[\>/=\] 12 months of non-therapy-induced amenorrhea) or surgically sterile (absence of ovaries and/or uterus): agreement to remain abstinent or use two adequate methods of contraception, including at least one method with a failure rate of less than (\<) 1 percent (%) per year, during the treatment period and for at least 18 months after the last dose of study drug * for men: agreement to remain abstinent or use two adequate methods for contraception, including at least one method with failure rate of less than 1% per year during the treatment period and for at least 6 months (180 days) after the last dose of drug
a pathology reference laboratory for the study of infectious diseases and malignant lymphoma

Conditions: Lymphoma

Summary: 1. to establish a pathology reference laboratory for the consultation on the diagnosis of infectious diseases and lymphoma. 2. to study the specific pathogens on 100 cases of unexplained death due to infectious diseases in the files of taiwan cdc and the forensic institutes of department of law and justice. 3. to study the distribution of children lymphoid lesions in vietnam and taiwan and their virus association. 4. to establish a tissue bank for infectious diseases and lymphoma.


Eligibility criteria:
inclusion criteria: clinical diagnosis of infectious diseases and lymphoma. exclusion criteria:
acceptability, feasibility, and development of an ai driven, multi-sensor, non-invasive digital mental health platform in children with adhd and emotional symptoms

Conditions: ADHD; Autism

Summary: this is an observational study collecting data using a wearable to measure the biometric features in youth with attention deficit hyperactivity disorder(adhd) and autism.

participants in therapeutic school for disruptive behavior with attention deficit hyperactivity disorder( adhd), autism with age 4-7 year old. participant will wear watch during their school days for 5 days in presence of investigator and raters taking behavioral observation. the data collected from the raters and wearable will be analyzed to correlate emotional dysregulation.

Eligibility criteria:
inclusion criteria: * children in the therapeutic school, diagnosed with adhd exclusion criteria: * unable to tolerate wearing the watch