chemotherapy in treating children with recurrent or refractory sarcomas

Conditions: Sarcoma

Summary: phase ii trial to study the effectiveness of topotecan in treating children who have recurrent, relapsed, or refractory sarcoma. drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.

objectives: i. determine the response rate in children with recurrent or refractory brain tumors, sarcomas, or neuroblastomas treated with topotecan. (brain tumor and neuroblastoma strata closed to accrual effective 07/02/2001) ii. assess the toxicity of this regimen in a larger group of patients treated at the currently defined maximum tolerated dose. outline: this is a multicenter study. patients receive topotecan iv continuously on days 1-21. treatment continues at least every 4 weeks in the absence of unacceptable toxicity or disease progression. patients are followed every 3 months.

Eligibility criteria:
disease characteristics: * histologically confirmed malignancy that is relapsed or refractory to conventional therapy at original diagnosis including: * brain tumors * gliomas or astrocytomas * medulloblastomas or primitive neuroectodermal tumor (pnet) in cns * (brain tumor stratum closed to accrual effective 07/02/2001) * sarcomas * soft tissue sarcoma (undifferentiated sarcoma, embryonal or alveolar rhabdomyosarcoma (rms), or non-rms soft tissue sarcoma) * osteosarcoma * ewing's sarcoma/peripheral pnet tumors * neuroblastoma * (neuroblastoma stratum closed to accrual effective 07/02/2001) * histology requirement waived for brain stem tumors (brain tumor stratum closed to accrual effective 07/02/2001) * measurable disease documented by clinical, radiographic, or histologic criteria * lesions in previously irradiated fields may be used to assess tumor response if there has been evidence of subsequent tumor growth in those fields * no bone marrow metastases with granulocytopenia and/or thrombocytopenia patient characteristics: age: * 30 days to 21 years at diagnosis performance status: * ecog 0-2 life expectancy: * more than 2 months hematopoietic: * absolute neutrophil count at least 1,000/mm3 * hemoglobin at least 10.0 g/dl (may receive rbc transfusions) * platelet count at least 100,000/mm3 (50,000/mm3 if post bone marrow transplantation) (transfusion independent) hepatic: * bilirubin no greater than 1.5 times normal * sgot or sgpt less than 2.5 times normal renal: * creatinine no greater than 1.5 times normal or * creatinine clearance or radioisotope glomerular filtration rate at least 70 ml/min neurologic: * no greater than grade 2 cns toxicity or * stable cns status for brain tumors (brain tumor stratum closed to accrual effective 07/02/2001) * seizure disorders allowed if well-controlled with anticonvulsants other: * not pregnant or nursing * negative pregnancy test * fertile patients must use effective contraception prior concurrent therapy: biologic therapy: * at least 3 months since prior bone marrow transplantation and recovered * at least 2 weeks since prior cytokines and recovered * no concurrent filgrastim (g-csf) or other cytokines * no concurrent immunomodulating agents chemotherapy: * at least 2 weeks since prior chemotherapy (4 weeks for nitrosoureas) and recovered * no prior topotecan or other camptothecins * no other concurrent anticancer chemotherapy endocrine therapy: * concurrent corticosteroids for cns tumors with increased intracranial pressure allowed (brain tumor stratum closed to accrual effective 07/02/2001) radiotherapy: * at least 2 months since prior craniospinal radiotherapy or radiotherapy to more than 50% of the bone marrow and recovered * concurrent radiotherapy to localized painful lesions allowed provided that at least 1 measurable lesion is not irradiated other: * recovered from any other prior therapy

Keywords: recurrent childhood rhabdomyosarcoma recurrent osteosarcoma embryonal childhood rhabdomyosarcoma alveolar childhood rhabdomyosarcoma recurrent childhood soft tissue sarcoma extraosseous ewing sarcoma/peripheral primitive neuroectodermal tumor recurrent ewing sarcoma/peripheral primitive neuroectodermal tumor