Kornimate/medical-research-clean huggingface dataset:
rowing following breast cancer chemotherapy

Conditions: Breast Cancer Survivors

Summary: there are more than 3.8 million breast cancer survivors in the united states and cancer survivors have a higher risk of cardiovascular disease (cvd) due to chemotherapy than adults without cancer. cardiovascular rehabilitation can be an effective strategy to decrease the incidence of cvd and its risk factors in this population. the proposed study may help to examine the effect of a novel exercise intervention on cardiovascular rehabilitation in breast cancer survivors.


Eligibility criteria:
inclusion criteria: * diagnosis of primary invasive non-metastatic breast cancer, stages i-iii * female based on biological sex * 40 to 80 years of age * completed breast cancer treatment 6 to 24 months prior to study enrollment. adjuvant endocrine therapy for breast cancer (e.g., ovarian suppression, serms, serds, ais), cdk4/6 inhibitors, parp inhibitors, her2 targeted agents, immunotherapy and bisphosphonates are allowed within 6 months prior to study enrollment and during study participation * absence of contraindications to exercise or study participation * study clinician approval exclusion criteria: * do not meet inclusion criteria * receiving or scheduled to receive treatment for breast cancer (i.e., chemotherapy, surgery, or radiation) during study participation is not allowed. adjuvant endocrine therapy, cdk4/6 inhibitors, parp inhibitors, her2 targeted agents, immunotherapy and bisphosphonates are allowed during study participation * lymphedema stage ≥ 2 prior to study enrolment * any relevant cardiovascular diseases (stroke, heart failure, myocardial ischemia during maximal graded exercise test, myocardial infarction, angina pectoris, coronary artery bypass surgery or angioplasty or coronary stent) * current participation in other experimental interventions that may confound interpretation of study findings (e.g., dietary intervention for weight loss) * consistent participation in ≥150 min/week of moderate-intensity rowing exercise training in previous 6 months
effects of the mbhp on the quality of life of family members of people with intellectual disability

Conditions: Quality of Life

Summary: the research aims to verify the effects of the mindfulness based health promotion (psbm) program on the quality of life of mothers of person with intellectual disability. method: a randomized, controlled study with pre-post intervention measures and a follow-up measurement will be performed after six months of the end of the intervention. sample: it will be composed of mothers of the 209 attended with moderate intellectual disability, adolescents and adults of the service of socioeducation of the association of parents and friends of the exceptional (apae) of são paulo, excluding those who have any psychiatric problem in the acute phase and minors, or who have regular practice of mindfulness or meditation in the last 6 months.

outcomes and instruments to be used: as primary endpoint the quality of life of the family caregiver will be observed and as a secondary outcome the caregiver's overload will be observed. as explanatory variables will be considered anxiety, depression, functionality and level of attention to the present moment (mindfulness). the investigators will use focal group, sociodemographic questionnaire, world health organization disability assessment scale, hospital anxiety and depression scale, brief autocompaction scale, world health organization quality of life scale brief version, mindful attention awareness scale, qualitative analysis questionnaire - semi-structured, informal caregiver burden assessment questionnaire, number of practices and adverse effects. procedure: the mothers of people with intellectual disability (id) will be invited to participate in the research protocol. having knowledge of the subject, agreeing to participate and signing the consent form, will respond to the questionnaires identified above, with a total duration of approximately 1 hour and 30 minutes. subsequently the participants will be randomized into two groups, in which one will receive the mindfulness intervention and the other, active control, will participate in a problem solving training. the protocols of questionnaires and focal group will be performed before, immediately after the accomplishment of the groups and in the follow-up of six months. the intervention group will last 8 weeks, according to the mindfulness based health promotion program (psbm) and during this same period the active control group will occur. hypotheses and expected results: mindfulness is expected to contribute to the improvement of the quality of life of this population, and so the investigators can contribute to the scientific increase in the theme.

Eligibility criteria:
inclusion criteria: * above 18 years * being a mother with sase di * be in accordance with the informed consent form exclusion criteria: * under 18 years * acute psychiatric problem * regular practice of mindfulness or meditation in the last 6 months
detection of cancer in breath samples by trained detection dogs

Conditions: Breast Cancer; Colorectal Cancer; PROSTATE CANCER; Lung Cancer

Summary: the goal of this study is to show that trained detection dogs can identify breast, lung, prostate or colorectal cancer by sniffing masks containing breath samples. in this study, individuals who will undergo cancer screening at an integrated cancer prevention center or biopsy for a suspected malignancy, will be asked to provide a breath sample by breathing into a surgical mask. the mask will then be sent to the laboratory, where trained detection dogs will determine if the person who provided the mask has breast, lung, prostate or colorectal cancer or if the person does not have these types of cancer. the results provided by the dogs will be compared to the actual cancer screening results or biopsy results in order to determine the accuracy of cancer detection by the trained dogs.


Eligibility criteria:
inclusion criteria: 1. men and women aged 18 and over. 2. signing an informed consent prior to performing the test. 3. intended to undergo screening tests for cancer detection. 4. did not smoke 2 hours before providing the breath sample 5. did not drink coffee in the hour before providing the breath sample 6. did not drink an alcoholic beverage in the hour prior to providing the breath sample. 7. did not eat food in the hour before providing the breath sample. exclusion criteria: 1. was diagnosed with cancer or was treated for cancer in the seven years preceding the study, excluding non-metastatic skin tumors that were surgically removed. 2. undergoing chemotherapy for any purpose. 3. pregnant or breastfeeding 4. had a medical procedure in the chest cavity and/or airways in the two weeks prior to providing the breath sample that may interfere with the ability to correctly provide a breath sample. 5. has a helicobacter pylori infection. 6. has a peptic ulcer disease. 7. has a flare-up of an inflammatory bowel disease (crohn's disease/ulcerative colitis). 8. has an active infection, such as covid-19, abscess, bacterial/viral/fungal infection, pneumonia, laryngitis, intestinal inflammation, active tuberculosis infection.

Keywords: breath sample detection dogs cancer screening
high intensity training in patients with spinal and bulbar muscular atrophy

Conditions: Spinal and Bulbar Muscular Atrophy; Healthy Subjects

Summary: we want investigate if high intensity training can increase daily functionality without causing muscle damage in patients spinal and bulbar muscular atrophy . we want to study if there is a difference in effect with supervised and unsupervised training. furthermore we want to study if a supervised training program will motivate participants to continue training by the end of the program.


Eligibility criteria:
inclusion criteria: * diagnosed with spinal and bulbar muscular atrophy or * healthy control subjects matched individually with participating patients on age, sex, bmi and activity level. exclusion criteria: * more than 1 hour of fitness weekly before inclusion * other disease possibly confounding the results * pregnancy or breastfeeding * participations in other scientific studies wich could influence on the results during the last 30 days before inclusion. * physical and/or mental conditions preventing participating in the study protocol.

Keywords: kennedy's disease spinal and bulbar muscular atrophy high intensity training high intensity interval training hit hiit training exercise 10-20-30
the reliability of the nine hole peg test in patients with multiple sclerosis

Conditions: Motor Activity

Summary: the main aim of the project is to establish inter-rater reliability, internal variability and variability of results got in two different ways of the nine hole peg test administered according to the new czech extended version manual in patients with multiple sclerosis.

at least 30 patients with multiple sclerosis will be tested by nine hole peg test according to new czech manual for this test. the testing will take place in one session. video of patients' performance will be obtained. the inter-rater reliability, internal variability and variability of results got in two different ways will be established.

Eligibility criteria:
inclusion criteria: * outpatients with clinically definite multiple sclerosis * czech language as a mother tongue * age from 20 to 65 years * clinically stable disease (more than 30 days since the last attack of the disease) * expanded disability status scale (edss) score between 1.5-8.0 exclusion criteria: * inability to complete the test attempt of the nine hole peg test * vision impairment uncorrectable with glasses * severe hearing loss * inability to understand instructions * inability to complete complete testing * failure to sign informed consent for the patient and consent to the collection and processing of personal data during the study at the general university hospital in prague

Keywords: occupational therapy fine motor skills nine hole peg test inter-rater reliability variability multiple sclerosis
effects of mini implant facilitated micro-osteoperforations on the alignment of mandibular anterior crowding

Conditions: Tooth Position Anomalies

Summary: the primary aim of the present study is to evaluate the the efficacy of micro-osteoperforation (mops) perfomed by mini-implant (mi) screw in improving alignment of mandibular anterior teeth

primarily the present study is designed to evaluate the efficacy of micro-osteoperation (mops) perfomed by mini-implant (mi) screw in improving alignment of mandibular anterior teeth. additionally, the possibility of inducing root resorption, and patient perception of pain during the initial phase of treatment. subjects and methods: orthodontic patients aged 17-25 years old, non-extraction treatment with lower anterior crowding of 4-6 mm using little's irregularity index. outcome measures included the amount of crowding using little's irregularity index (lii), apical root resorption, and pain perception. the effectiveness of alignment will be tested using t-test, while root resorption and pain perception will be tested by the mann-whitney u test, and wilcoxon signed-rank test (p\<0.05).

Eligibility criteria:
inclusion criteria: 1. age range between 17-25years 2. non-extraction treatment in the mandibular arch 3. presence of full complement of dentition from first molar to first molar 4. mandibular anterior irregularity index between 4-6 mm 5. patient with healthy periodontium and no attachment loss of \>2 mm exclusion criteria: 1. previous orthodontic treatment 2. presence of primary or missing permanent teeth in the mandibular anterior area 3. medical problems that affect tooth movement.
the impact of a virtual magic trick training program

Conditions: Autism; Pervasive Developmental Disorder

Summary: the proposed project will attempt to confirm the benefits of a structured magic trick training program (mttp) experience in adolescents with autism. benefits of participating in a 6-week virtual mttp will be evaluated using validated assessments to measure social-emotional competencies.

the proposed study will employ a rct to test the two hypotheses. the design of the mttp is based on the sel framework. the study will incorporate a 2 x 3 two-way factorial design with repeated measures at three time points. the two between-subject factor conditions will be participation in a mttp versus a waitlist control condition that will be evaluated at baseline, immediately post-program, and at 6-week follow-up (within-subject factor conditions). sixty adolescents with autism will be recruited for this study. aim 1. evaluate the therapeutic benefits of a 6-week virtual mttp on social-emotional functioning, and emotional stress among adolescents with autism. hypothesis #1: adolescents with autism who participate in a virtual mttp will demonstrate better social-emotional functioning, and a reduction in emotional stress compared to waitlist controls at the conclusion of a 6-week mttp. hypothesis #2: the positive impact of the virtual mttp on the participants' improved social-emotional functioning, and reduction in emotional stress will be maintained at 6-week follow-up.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis (with proof of evidence) of autism; * aged between 11 and 18 years (younger children may lack the inductive reasoning skills to learn magic tricks); * have functional hand dexterity to do magic tricks * intact cognition as indicated by a score above the corresponding cut-off point of the child's age on the mini-mental examination for children; and * access to internet and a computer or smartphone that can perform videoconferencing. exclusion criteria: * severe hearing or visual impairments that prevent online learning; * previous participation in organized magic learning program or camp; * current or planned participation in psychological therapy or a clinical trial during the study period that could affect the outcomes of the study.
study of combined visiocyt test and fgfr3 mutations on a urinary sample to diagnose bladder tumors

Conditions: Bladder Cancer

Summary: this study is a case-control, propsective and muticentric clinical trial, which aim to compare the specificity and sensibility of visiocyt urinary cytological test combined with fgfr3 mutation detection test to visiocyt urinary cyological test on its own to detect bladder cancer. the case are patient in whom newly diagnosed, or recurring /progressing bladder cancer is strongly suspected after initial fibroscopy. the control are patient attending or hospitalized for urolithiasis, urinary infections, urinary superior excretory stones or with non suspect urinary symptomatology.


Eligibility criteria:
inclusion criteria both groups * m/f * patient agrees to follow study protocol and is able to follow study procedures * patient signed, dated and understood consent form * patient has a social security scheme case group * patient is 18 or older * patient for whom a bladder cancer recently diagnosed, or backsliding/progression is heavily suspected after the initial fibroscopy * patient who hasn't started systemic/oral/radiotheurapeutic pelvic treatment for his/her tumor control group * patient between 18 and 45 y/o * patient not suspected of having any bladder cancer * patient attending or hospitalized for urolithiasis, urinary infections, superior excretory stones or with non suspect urinary symptomatology * patient who hasn't been exposed to bladder carcinogens (tobacco, industrial carcinogen (ex: coal tar, tar/coal oils, coal pitch and burning coal soot), urinary bilharzia, chemotherapy exposition (cyclophosphamid) * patient that had a negative cytopathological exploration of the excretory urinary route or/and iconography (pelvic echography, pelvic scanner) or/and endoscopy with prior urinary sample * patient unscathed of any cancer that might interact with bladder cancer : uterine cancer, prostate cancer, rectal cancer, and metastasis from other cancer or non-urologic tumor invading the bladder exclusion criteria both groups * non-treated current urinary infection * patient with another pelvic cancer * bladder cancer outside of urothelial carcinoma * associated carcinoma of the high urinary apparatus * patient that received renal transplantation (bk virus) * patient that received pelvis radiotherapy (related to prostatic cancer, gynecologic cancer or pelvic digestive cancer) * patient having a jj catheter * refused to signed consent * pregnant, susceptible to be, or breast-feeding women * person under guardianship * impossibility to submit to medical monitoring because of geographic, social, or mental issues case group • under 18y/o control group • under 18y/o or above 45 y/o

Keywords: fgfr3 visiocyt bladder tumor cancer fgfr3 mutation diagnosis cytoloogy
dutch cangrelor registry

Conditions: STEMI - ST Elevation Myocardial Infarction; NSTEMI - Non-ST Segment Elevation MI; Coronary Artery Disease

Summary: cangrelor is a fast and directly acting platelet aggregation inhibitor. it is potentially indicated for several types of patients who are undergoing pci. a nationwide cangrelor registry has up until now not been performed and with the introduction of cangrelor in the netherlands its efficacy and safety will be determined.


Eligibility criteria:
inclusion criteria: * age ≥18 years * one of the following criteria: * patients naïve for p2y12 inhibition undergoing pci * patients with suboptimal p2y12 inhibition undergoing pci (patients who vomited after p2y12 loading, out of hospital cardiac arrest (ohca) patients with restoration of spontaneous circulation (rosc), patients loaded with p2y12 inhibitors though platelet inhibition still insufficient (\<2 hours after oral loading dose) * (n)stemi patients loaded with p2y12 inhibitors with large thrombus burden (thrombus grade 4 or 5) on initial coronary angiography (cag) and undergoing primary pci with expected insufficient p2y12 inhibition exclusion criteria: * patients on current/chronic treatment with p2y12 inhibitors * patients (pre) treated with a gpi * patients with recent major bleeding complications or contraindication to dual antiplatelet therapy: * hypersensitivity or allergy to and known contra-indication for aspirin, clopidogrel, ticagrelor or cangrelor * history of major clinical bleeding or known coagulopathy * active bleeding * history of intracerebral mass, aneurysm, arteriovenous malformation, or hemorrhagic stroke * known severe liver dysfunction * patients that received any organ transplant or are on a waiting list for any organ transplant * patients undergoing dialysis * pregnant or lactating female * patients currently participating in another investigational drug or device study
methylation of p16 cpg island and malignant transformation of oral epithelial dysplasia

Conditions: Oral Epithelial Dysplasia, Mild or Moderate Grade

Summary: oral epithelial dysplasia (oed) is one of the common precancerous lesions among chinese adults. biomarker is not available for detection of malignant potential of oed till now. p16 is an important tumor suppressor gene, which is inactivated frequently by methylation of cpg island in early stage of carcinogenesis. the present cohort study is to investigate whether p16 methylation is correlated with malignant transformation of oed.

* background: identification of malignant potential of oral epithelial dysplasia (oed) is virtually impossible on histopathological grounds alone. inactivation of p16 gene by cpg methylation is an early frequent event during oral carcinogenesis. to investigate the predictive value of p16 methylation on malignant potential in oed, we carried out the prospective cohort study. * methods: 101 patients with histologically confirmed mild or moderate oed were included in the present study. baseline information of p16 methylation status of the oed lesions from 93 cases was obtained by methylation-specific pcr. progression of the oeds lesions was examined in 78 cases histologically during the 45.8 months double-blind followup survey (78/93). the association between p16 methylation and progression of oed was analyzed with spss13.0 software. all p-values were two-sided.

Eligibility criteria:
inclusion criteria: * histological diagnosis of mild or moderate grade oed; and * enough amount of tissue sample from oed lesion for genomic dna extraction; and * available of methylation status of p16 cpg island in the extracted dna sample. exclusion criteria: * histological diagnosis of severe grade oed or malignant disease; or * amount of tissue sample is not enough for preparation of genomic dna (20ng); or * quality of the prepared dna is not good enough for detection of p16 methylation; or * oed treatment history by laser, radiotherapy, or chemotherapy

Keywords: oral epithelial dysplasia p16 methylation prognosis malignant transformation oral squamous cell carcinoma
evaluation of the effects of heating or massaging or vibrating at the vicinity of the insulin delivery site

Conditions: Diabetes

Summary: the aim of this study is to test the pharmacodynamics of insulin analogs and their dependence on external and physiological alterations. we plan to compare the pharmacodynamics of insulin analog delivery in regular conditions and in the presence of increased perfusion of the delivery site, achieved by way of local warming and movement


Eligibility criteria:
inclusion criteria: 1. participant age between 18- 65 years old 2. type i or type ii diabetes 3. hba1c 6-12% 4. does not suffer from sever hypertension, kidney, liver or heart disease 5. does not suffer from active ischemic heart disease 6. is willing to sign the consent form exclusion criteria: 1. participants age \ 65 2. pregnancy 3. breast feeding women 4. un-controlled diabetes, hba1c values \> 12% range 5. suffers from active ischemic heart disease 6. alcohol addiction 7. is not prepared to signed the informed consent

Keywords: diabetes post prandial glucose level insulin pharmacokinetics pharmacodynamics
a prospective exploratory clinical study of metronomic capecitabine as adjuvant therapy in locoregionally advanced hypopharyngeal carcinoma

Conditions: to Explore Whether the Adjuvant Therapy of Metronomic Capecitabine Could Improve the Disease-free Survival of Locoregionally Advanced Hypopharyngeal Carcinoma

Summary: to explore whether the adjuvant therapy of metronomic capecitabine could improve the disease-free survival of locoregionally advanced hypopharyngeal carcinoma (stage iv：t4n0-1m0，anytn2-3m0).


Eligibility criteria:
inclusion criteria: * 1. age between 18 and 65 years old. 2. histologically confirmed hypopharyngeal carcinoma, staged as iv (t4n0-1m0，anytn2-3m0) (as defined by the 8th ajcc edition), complete the recommended standard treatment (curative chemoradiotherapy, or radical surgery + postoperative chemo/radiotherapy ). 3. no clinical evidence of persistent locoregional disease or distant metastases after definitive chemoradiotherapy. 4. within 8 weeks after completion of the last radiation dose. 5. performance status of ecog grade 0 or 1. 6. adequate hematologic (neutrophil count \> 1.5×10\^9/l, hemoglobin \> 90g/l and platelet count \> 100×10\^9 /l), hepatic (alanine aminotransferase, aspartate aminotransferase ≤ 1.5×uln, bilirubin ≤ 1.5×uln, alkaline phosphatase \ 50 ml/min). 7. patients must be appraised of the investigational nature of the study and provide written informed consent. exclusion criteria: * 1.patients who were known to be intolerable or allergic to capecitabine. 2. prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer. 3. any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control). 4. with esophagus cancer. 5. pregnancy or lactation. 6. other conditions that are not eligible for enrollment.