Kornimate/medical-research-clean huggingface dataset:
evaluation of quality of life and psychosocial status in children with inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases; Psychosocial Impairment

Summary: inflammatory bowel disease (ibd) is a chronic condition that affects the psychosocial status and physical activities of children and their parents in many ways. our study aimed to investigate the variability of disease-related quality of life and behavioral and emotional adjustment issues compared to a healthy control group among adolescents and their families diagnosed with ibd. children with ibd and the healthy control group, as well as the parents of both groups, will administered the pediatric quality of life inventory (pedsql) and strengths and difficulties questionnaire (sdq). the pedsql is a scale used to assess physical and psychosocial functioning based on the individual's own experiences, commonly employed in clinical trials and quality improvement initiatives. the scale evaluates physical activity status and psychosocial functioning through questions related to emotional, social, and school-related issues.


Eligibility criteria:
inclusion criteria: * aged between 8-17 years * diagnosed inflammatory bowel disease * healthy adolescents aged between 8-17 years exclusion criteria: * not obtaining informed consent * diagnosis of psychiatric disorder

Keywords: inflammatory bowel diseases psychosocial condition crohn's disease ulcerative colitis
edinburgh pain assessment tool (epat©) study

Conditions: Cancer

Summary: to determine if the institutionalisation of a regular systematic approach to the assessment of pain in inpatient cancer units using the edinburgh pain assessment tool (epat©) leads to better control of pain than that achieved by usual care.

background and relevance to cancer - pain associated with cancer has a severe negative impact on quality of life and can also limit a patient's ability to tolerate potentially life-saving tumoricidal treatment. unfortunately in practice only half of cancer patients receive adequate pain control. a fundamental reason for this is inadequate assessment of pain. the institutionalisation of pain assessment as a 5th vital sign on the bedside chart combined with training and guidance in pain management (epat) is a potentially effective solution. we have already evaluated the feasibility and efficacy of epat in a randomised trial of 150 oncology inpatients and found that by day 4 after admission 90% reported adequate pain control compared to only 52% of those who received usual care. aims - we now want to evaluate the effectiveness and cost-effectiveness of epat in practice and ask: does it reduce cancer pain more that usual care? are there adverse effects? is it cost effective? outline plan - a uk-wide cluster randomised controlled trial of 18 inpatient cancer centres of which half will use the epat package and half usual care. the trial outcomes are clinically significant improvement, adverse effects such as opiate toxicity and cost effectiveness.

Eligibility criteria:
inclusion criteria: * able and consent to complete a brief pain inventory score * aged over 18 years * have a pain score equal to or greater than 4 out of 10 at first assessment point (within 24 hours of admission) and pain is cancer related * are expected to be available for pain assessment at 3 days after admission exclusion criteria: * do not consent to take part in the study or who are too ill to take part, including those with severe mental health problems * do not have cancer-related pain * are under 18 years of age * have a pain score of less than 4 * are not expected to be available for pain assessment at 3 days after admission

Keywords: institutional change improved pain management
the safety & efficacy of terlipressin vs octreotide for the control of variceal bleed

Conditions: Portal Hypertension; Cirrhosis; Hematemesis; Melena

Summary: terlipressin and octreotide are two common agents used as adjuvants in the management of variceal bleeding. both agents have been claimed equivalent to endoscopic therapy in randomized studies. there are no head to head clinical trials of these two agents available in the literature. we aimed to compare the efficacy and safety of terlipressin and octreotide in combination with endoscopic variceal band ligation (evl)in patients presenting with esophageal variceal bleed (evb).

the effectiveness of combining endoscopic treatment with octreotide or terlipressin has not been prospectively studied in esophageal variceal hemorrhage (evh). this prospective, randomized clinical trial will help us in better patient management more efficiently and cost effectively.

Eligibility criteria:
inclusion criteria: * all cirrhotic patients with upper gi bleed secondary to esophageal varices of 18 years or more of age exclusion criteria: * ulcerative esophagitis, * mallory weiss tear, * bleeding gastric or duodenal ulcers, * bleeding from gastric varices or portal hypertensive gastropathy and * upper gi bleed as a result of thrombocytopenia or bleeding diathesis.

Keywords: variceal bleed cirrhosis vasoactive agents terlipressin octreotide safety & efficacy
the effects of video based training and aerobic exercise training in individuals with internet gaming disorder

Conditions: Gaming Disorder; Sedentary Behavior

Summary: in this study, video-based training, aerobic training and both training will be applied to individuals with internet gaming disorder. addiction levels and functional performance will be evaluated before and after treatment.

the aim of this study is to investigate the effect of game-based training and aerobic exercise training on game addiction level, functional performance and exercise capacity in individuals with internet play disorder. in addition, the investigators think that facilitate the transition to exercise by using game-based training in order to gain exercise habit and reduce sedentary behaviours in individuals with internet gaming disorder.

Eligibility criteria:
inclusion criteria: * dsm v (diagnostic and statistical manual of mental disorders, revision 5) internet gaming impairment (ioob) diagnostic criteria: approval of five to nine items * no communication barrier * playing game (smart phone,play station 4, xbox, personal computer) at least 2 hours a day in the last year exclusion criteria: * cigarette use over 10 packsxyear * be using any medicine * be actively involved in any sport. * having chronic disease * having physical disability

Keywords: gaming disorder aerobic exercise exergame
effectiveness of the use of the nintendo switch combined with conventional therapy in people with acquired brain injury

Conditions: Occupational Therapy; Acquired Brain Injury; Adults

Summary: purpose: to observe the possible benefits produced by conventional therapy through virtual reality with the nintendo switch to try to improve motivation and increase the degree of care satisfaction. the aim is to improve postural control in both seated and standing positions and to maintain and improve cognitive capacity. material and methods: one group (experimental group) will receive a total of 8 one-hour sessions or 16 half-hour sessions, depending on their individual needs, for 8 weeks using the nintendo switch. the other group (control group) will continue to receive their conventional scheduled therapy. measures: abilhand, mec-lobo, fist, fugl-meyer, berg balance scale and csq-8.


Eligibility criteria:
inclusion criteria: * adult men and women, over 30 years of age who have suffered an acquired brain injury. * mild or moderate cognitive impairment as measured by the mec-lobo test (score greater than 23/35). * regularly attend some conventional therapy (neuropsychology, physiotherapy or occupational therapy). * agree to participate voluntarily by signing the informed consent form. exclusion criteria: * present severe cognitive impairment as measured by the mec-lobo test (less than 23/35). * present aphasia of comprehension or expression. * present associated neurodegenerative pathology. * present any pathology underlying the acquired brain damage (diabetes, heart disease, copd, etc.), heart disease, copd, etc.). * voluntarily refuse to participate in the study.
virtual reality distraction in patients undergoing periodontal surgery

Conditions: Virtual Reality; Oral Surgery; Dental Anxiety

Summary: the goal of this randomized controlled clinical trial is to evaluate the effect of virtual reality technology on anxiety and pain levels in patients undergoing periodontal surgery. participants will be randomly assigned into test and control groups. while the patients in the test group will undergo periodontal surgery with virtual reality distraction, the patients in the control group without distraction. after treatment, the groups will be compared regarding anxiety and pain levels.


Eligibility criteria:
inclusion criteria: * individuals over the age of 18 * systemically healthy patients * need for periodontal surgical treatment in the mandibular anterior region * scoring 15 or above on the modified dental anxiety scale exclusion criteria: * having a history of seizures or a convulsive disorder * balance disorders such as nystagmus, vertigo * use of psychotropic drugs * getting treatment for anxiety * presence of dermatological lesions on the face, especially around the eyes * a lesion in the eye that will prevent the use of virtual reality glasses * systemic disease and medication use that contraindicate periodontal surgery
efficacy and safety of vda-1102 ointment in the treatment of actinic keratosis

Conditions: Actinic Keratosis

Summary: this phase 2 clinical trial is a multi-center, randomized, double-blind, placebo-controlled, multiple-dose, parallel-cohort study to assess the efficacy, safety and tolerability of vda-1102 in the treatment of actinic keratosis (ak) on the head of male and female adult subjects.

approximately 84 subjects who meet the study's enrollment criteria at the completion of the screening period will be randomized to receive 5% or 10% vda-1102, or matched-placebo. during the treatment period, study drug will be applied once-daily for 28 days to a 25 square centimeter area of skin containing 4-8 actinic keratosis lesions on the face or scalp. subjects will be followed for an additional 28 days (observation period) wherein no study drug will be applied. the purpose of the study is to determine whether once-daily application of vda-1102 ointment for 28 days is effective and well-tolerated in the treatment of actinic keratosis of the face and scalp.

Eligibility criteria:
main inclusion criteria: * subject has a minimum of 4 and a maximum of 8 discrete grade 1-2 ak lesions within a single 25 square centimeter area of skin on their scalp or face main exclusion criteria: * subject is: (a) pregnant; (b) lactating; (c) planning to become pregnant during the study, or (d) fertile and they or their fertile partner is unable or unwilling to use the required contraceptive methods * subject is immunosuppressed * subject has used any of the following topical treatments in the treatment field: (1) topical retinoids within 8 weeks of screening or (2) micro-dermabrasion, laser ablative treatments, ala-pdt, chemical peels, 5-fu, diclofenac, imiquimod, ingenol, or other topical treatments for ak or that might impact ak within 12 weeks of screening. * subject has used systemic retinoid therapy within 6 months of screening visit.

Keywords: topical ointment skin hexokinase precancerous conditions carcinoma, squamous cell
comparison suprascapular nerve block and subacromial injection in hemiplegic shoulder pain

Conditions: Hemiplegia; Pain

Summary: hemiplegic shoulder pain is the most common poststroke painful condition. hemiplegic shoulder pain reduces range of motion (rom) and hand function, resulting in limited daily life activity and decreased quality of life. in the literature, the effectiveness of suprascapular nerve block and subacromial injection in hemiplegia patients with shoulder pain has been previously evaluated, but these injection treatments have not been compared. therefore, the aim of this study is to compare the effectiveness of suprascapular nerve block and subacromial injection on pain, shoulder (rom), function and quality of life in hemiplegia patients with shoulder pain.

patients will be randomly assigned subacromial injection group or suprascapular nerve block group in the suprascapular nerve block group, suprascapular nerve block will be performed with a mylab60 model a high resolution 7-12-mhz linear probe ultrasonography device. after the suprascapular fossa will be observed by ultrasonography, a betamethasone dipropionate plus betamethasone sodium phosphate solution (6.43 mg / ml + 2.63 mg / ml; 1 ml), 0.5 % bupivacaine (2 ml) and physiological serum (2 ml) will be injected with an in-plane technique using a 22 gauge 90-mm injector. in the subacromial injection group, subacromial injection will be performed with a mylab60 model a high resolution 7-12-mhz linear probe ultrasonography device. after the subacromial bursa will be observed by ultrasonography, a betamethasone dipropionate plus betamethasone sodium phosphate solution (6.43 mg/ml + 2.63 mg/ml; 1 ml), 2% lidocaine (2 ml) and physiological serum (2 ml) will be injected with an in-plane technique using a 21 gauge 38-mm injector. a home exercise program will be given both groups. the exercise program consisted of passive and active-assistive rom exercises (3 sets daily, 20 times in each set).

Eligibility criteria:
inclusion criteria: * brunstrom stage 2 to 5 * spasticity \<4 according to the modified ashworth scale * having hemiplegia less than 12 months * presence of shoulder pain lasting more than 3 months * conservative treatment for painful shoulder before injection exclusion criteria: * patients over 75 years old, under 30 years old * anti-coagulant or antiaggregant use * presence of diabetes mellitus * patients who could not be cooperated and mini-mental test (mmse) score \<24 * having previously had suprascapular block or subacromial injection * presence of complex regional pain syndrome (type i), * the presence of neglect syndrome
weight loss-independent metabolic effects of roux-en-y gastric bypass in diabetes

Conditions: Obesity; Type 2 Diabetes

Summary: for this purpose, we will compare the effects of targeted 16-18% (with a range of 16-25%) weight loss induced by roux-en-y gastric bypass (rygb) surgery with the same weight loss induced by a low-calorie diet (lcd) on liver and skeletal muscle insulin sensitivity, beta-cell function, and 24-hour metabolic homeostasis in obese subjects with or without t2d.


Eligibility criteria:
inclusion criteria: for rygb group: * scheduled for this bariatric surgery * body mass index (bmi) 34-55 kg/m² * type 2 diabetes * signed informed consent for low-calorie diet group: * bmi 34-55 kg/m² * type 2 diabetes and non-diabetics * signed informed consent exclusion criteria: for both rygb \& low-calorie diet groups * regular use of tobacco products * previous intestinal resection * pregnant or breastfeeding * evidence of significant organ system dysfunction or disease other than t2d * use of any medication that might, in the opinion of the investigator, affect metabolic function * exercise ≥90 minutes per week

Keywords: obesity roux-en-y gastric bypass (rygb) type 2 diabetes weight loss low-calorie diet
colonisation efficacy of a probiotic chewing gum.

Conditions: Microbial Colonization

Summary: to evaluate the colonization efficacy (the ability of a probiotic bacteria to remain in the mouth) delivered in a chewing gum format. the chewing gum contains streptococcus salivarius probiotic and the study is to be done in health adults.

this is a single blind, randomized controlled study to evaluate the colonization effectiveness of a chewing gum containing a commercially available probiotic bacterium. participants will be randomly assigned to one of the two groups consuming chewing gum containing streptococcus salivarius m18 over a 7-day period. saliva samples will be collected at pre determined points (pre and post intervention). colonization efficacy will be determined by enumerating the probiotic from the saliva samples using standard microbiological techniques.

Eligibility criteria:
inclusion criteria: * in general, good health * practice good oral hygiene exclusion criteria: * have a history of autoimmune disease or are immune compromised. * are on concurrent antibiotic therapy, or regular antibiotic use within last one week * people with allergies or sensitivities to dairy.
effect of medium chain triglyceride consumption on appetite

Conditions: Obesity

Summary: the purpose of this study is to test the effects of medium chain triglyceride consumption, relative to long chain triglycerides, on hormones involved in appetite regulation and food intake in overweight men. we expect medium chain triglycerides to reduce appetite and food intake and to do so by increasing levels of hormones known to be involved in satiety and reduce levels of those involved in appetite.


Eligibility criteria:
inclusion criteria: * males * weight stable (\<10 lb over previous 3 months) * overweight (body mass index 25-29.9) exclusion criteria: * smokers * excessive caffeine users * severe health conditions * allergy to food products/ingredients in the study * taking medications known to affect energy expenditure or gastrointestinal function
anagre cap. in patients with high-risk essential thrombocythemia

Conditions: Essential Thrombocythemia

Summary: this study is to evaluate the efficacy and safety according to incremental dosing for 8 weeks and duration of administration for 1 year in patients with high-risk essential thrombocythemia.


Eligibility criteria:
inclusion criteria: * patients with essential thrombocythemia according to who 2008 * any of the following as high-risk patient * over 60 years old * \>100 x 10\^4/ul of platelet count * increased more than 300k of platelet count in 3 months * hypertension, diabetes, past history of thromboembolic bleeding exclusion criteria: * patients with an adverse drug reaction or intolerability to anagrelide * any of the following cardiac abnormalities; * complete left bundle branch block on ecg * patients using a pacemaker * patients with a family history of congenital qt prolongation syndrome or known qt prolongation syndrome * currently, there is no clinically uncontrolled ventricular or atrial tachycardia * clinically significant bradycardia (\<less than 50 per minute) * history of clinically proven myocardial infarction and unstable angina within 3 months * pregnant women, nursing mothers
research of systemic management for late preterm infants nutrition in china

Conditions: Late Premature Infants; Systemic Nutritional Management

Summary: the purpose of the project is to investigate the status of nutrition management of late preterm infants in the member hospitals in the beijing association of preterm infants, and set up the systemic nutritional management of late preterm infants, including parenteral nutrition and enteral feeding. and to compare the differences of growth and complications of these infants between groupings applicationg and not applicating the systemic nutritional management of late preterm infants,and to validate its feasibility and validity.

the research content of the project includes three parts: 1. investigation on nutritional status of late preterm infants. 2. setting up systemic nutritional management of late preterm infants 3. comparing nutritional and growth status of the late preterm, short-term and long-term complications between the groups applicating and not applicating the systemic nutritional management of late pretern infants.

Eligibility criteria:
inclusion criteria: * preterm infants with gestational age 34 weeks to 36 weeks and 6 days exclusion criteria: * preterm infants with gestational age\ 36 weeks and 6 days * abnormality of digestive system * genetic and metablic disease * severe congenital heart disease( with hemodynamic changes that influencing enteral feeding)

Keywords: late preterm infants nutrition systemic management
efficacy of plasma rich in growth factors (prgf) in the treatment of foot ulcers in diabetic patients with peripheral arterial disease

Conditions: Foot Ulcers, Diabetic

Summary: this study is a randomized clinical trial that compares the effectiveness of plasma rich in growth factors (prgf) with conventional treatment for healing foot ulcers in diabetic patients who also have peripheral arterial disease. the goal is to assess how well prgf promotes healing over a six-month period.


Eligibility criteria:
inclusion criteria: * patients aged at least 18 years * diagnosis of type 1 or 2 diabetes * presence of one or more ulcers below the malleoli * ulcer size ranging from 1 to 25 cm2 * peripheral arterial disease (pad) * meet at least 2 of the following crieria: * absence of peripheral pulses at any level on physical examination of lower extremities * ankle pressure of 50-90 mmhg * finger pressure 30-70 mmhg * ankle-branchial index (abi) 0.5-0.9 * finger-arm index (fibi) 0.3-0.7 * transcutaneous oxygen pressure (tcpo2) 30-59 mmhg * degree of infection of the lesion on idsa/iwgdf scale not greater than 1 * availability of observation during the study period * properly completed patient informed consent exclusion criteria: * ulcers grade 3 or higher * positive markers for hcv, afhbs, hiv-i/ii or tp * diabetes mellitus with poor metabolic control (evidence of glycosylated hemoglobin \>9%) * active systemic infection * history of cancerous or precancerous lesions in the area of intervention * on active treatment with other local treatment at the site of treatment * on active treatment with immunosuppressants and/or other drugs contraindicating blood collection * history of allergy to blood derivatives * previous diagnosis of coagulopathies * regular and continuous treatment (≥ 3 months) with nsaids (with the exception of the use of acetylsalicilic acid) * pregnancy or women of chilbearig age not taking effective contraceptive measures. these methods are, according to recommendations of the clinical trial facilitation group (ctfg) contraception working group (ctfg) (v1.1), the following hormonal contraception associated with ovulation inhibition, intrauterine decide (iud), intrauterine hormone-releasing system, bilateral tubal ligation, vasectomy partner, sexual abstinence * breastfeeding women * treatment with monoclonal antibodies * any inabilities to participate in the study
ventilation weaning strategies and correlation to outcomes in tracheostomized patients in the lausanne icu

Conditions: Respiratory Failure; Tracheostomy Complication

Summary: this retrospective study aims to study characteristics of patients tracheotomized in the lausanne icu, both overall and by primary reasons of intubation. ventilation data both before and after tracheotomy, weaning technique and timing are studied in this retrospective study.


Eligibility criteria:
inclusion criteria: * all patients hospitalized in the lausanne icu between may 1st 2017 and november 31st 2018 with a tracheotomy and mechanically ventilated more than 72 hours. exclusion criteria: * presence of a know opposition to participation to research projects * patient tracheostomized specifically for ent (ear-nose-throat) reason * burn victim * patient tracheostomized before his/her admission to the lausanne icu

Keywords: tracheostomy ventilation weaning spontaneous breathing trial