Kornimate/medical-research-clean huggingface dataset:
tmj dysfunction: effects on proprioception, pain, and body awareness

Conditions: Temporomandibular Joint Disorders; Temporomandibular Disorder

Summary: the term "temporomandibular joint dysfunction" (tmj dysfunction) refers to a range of anatomical and functional problems, with or without clinical signs and symptoms, that affect the tmj and/or the chewing muscles. it is more frequent in women and young people ages between 20 and 40. its frequency ranges from 28% to 88%. the term "temporomandibular joint dysfunction" (tmj dysfunction) refers to a range of anatomical and functional problems, with or without clinical signs and symptoms, that affect the tmj and/or the chewing muscles. it is more frequent in women and young people ages between 20 and 40. its frequency ranges from 28% to 88%. this condition is frequently disregarded because of inadequate diagnosis . additionally, tmj dysfunction can particularly emerge in the early stages without the presence of pain. due to the insidious onset of the disease, especially in the early stages, other tmj-related factors, in addition to pain-related parameters, need to be considered.therefore, the aim of the study is to investigate the effect of tme disorder on proprioception, body awareness, and pain-related parameters including pain threshold, pain tolerance, and temporal summation in young adults.

"in the study, young adults aged 18-25 will be included, with tmj dysfunction being measured using the fonseca amnestic index. based on fonseca scores, two groups will be formed: those scoring over 20 will be labeled 'with tmj dysfunction,' while the others will be classified as 'without tmj dysfunction.' proprioception will be assessed both through self-reports using the fremantle neck awareness questionnaire and via joint position sense measured by a crom device. body awareness will also be evaluated using the body awareness questionnaire. pain assessment, including pain threshold, tolerance, and temporal summation, will be conducted using a pressure algometer. the 'pain threshold' will refer to the point at which a person first feels pain, 'pain tolerance' will be the last point that a person can tolerate, and 'temporal summation' will be the pain sensation evaluated after 10 repetitions of the pain threshold.

Eligibility criteria:
inclusion criteria: \*being between 18-25 years old exclusion criteria: * history of cervical spine injuries or disorders * chronic pain conditions or diagnosed musculoskeletal disorders * previous neck or spine surgeries * neurological or psychiatric conditions affecting proprioception or pain perception * use of medications influencing pain sensitivity or proprioception * pregnancy

Keywords: joint position sense quantitative sensory testing temporal summation cervical proprioception
a dose-finding study to evaluate ovarian function and vaginal bleeding in next generation rings (p06109/mk-8175a/mk-8342b-012)

Conditions: Contraception

Summary: the primary objective of this trial was to identify at least one next generation ring (ngr) that demonstrates inhibition of ovulation (which was considered confirmed if in the subset of participants ovulation was observed in less than 15% of the participants at any time during the 3 treatment cycles of the study) and cycle control that was non-inferior to nuvaring®, as judged by the incidence of breakthrough bleeding and/or spotting (btb-s) during cycle 3. the primary hypothesis was that at least 1 of the 6 ngrs would show inhibition of ovulation and cycle control during treatment cycle 3 that is non-inferior to nuvaring®, as judged by the incidence of btb-s.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) ≥18 and ≤35 * regular cycles from 24 to 35 days in length, with an intra-individual variation of ±3 days permitted within this range * good physical and mental health exclusion criteria: * diabetes mellitus with vascular involvement * presence of a severe or multiple risk factor(s) for venous or arterial thrombosis * severe dyslipoproteinemia * severe hypertension * presence or history of pancreatitis associated with severe hypertriglyceridaemia * presence or history of severe hepatic disease * undiagnosed vaginal bleeding * known or suspected pregnancy * participation in another investigational drug study within 30 days prior to screening visit * history of malignancy ≤5 years, except for adequately treated basal cell or squamous cell skin cancer, or in situ cervical cancer * documented abnormal cervical smear result in 6 months prior to screening visit * sterilization using a fallopian tube occlusion device (e.g., essure method) * sex hormone therapy within 2 months prior to screening visit for purpose other than contraception, or injectable hormonal contraception within 6 months prior to screening
validation of the adenomyosis calculator

Conditions: Adenomyosis; Pelvic Pain Syndrome

Summary: adenomyosis is a disease where ectopic endometrial glands affect the muscular wall of the uterus. women that suffer from dysmenorrhea or infertility caused by adenomyosis need to confirm or rule out adenomyosis, and therefore tools for non-histologic confirmation of adenomyosis are indubitably required. transvaginal ultrasound has been shown to be useful in diagnosing adenomyosis, but the interpretation of findings requires significant expertise in ultrasound and experience with diagnosing adenomyosis. this is because adenomyosis shows a very heterogeneous appearance in ultrasound. there are many different diagnostic signs that have to be considered and weighed. in a previous study, the investigators have developed a diagnostic algorithm that helps clinicians diagnose adenomyosis with transvaginal ultrasound and a clinical examination. it showed good diagnostic accuracy and seemed to be very robust with regards to artifacts and experience of the examiner. it is now necessary to validate this prediction model in a new, prospective study so it can be used in clinical practice.


Eligibility criteria:
inclusion criteria: * premenopausal (defined by having had menstruation the last six month) * if amenorrhea with levonorgestrel intrauterine device, the woman should be \< 45 years old * hysterectomy planned due to a benign condition * hysterectomy does not require morcellation it is allowed to divide the uterus into 2-3 pieces, given that the orientation of the specimen is still possible for the pathologist) * written consent is given * can communicate in norwegian or english at the norwegian study sites, and finnish, swedish or english at the finnish study site. exclusion criteria: * gynecological cancer present at the time of inclusion * use of gonadotropin-releasing hormone agonist or antagonist within the last 3 months prior to the ultrasound evaluation * prior endometrial ablation or resection * postmenopausal status or no menstrual bleeding for the last 6 months, or amenorrhea with levonorgestrel-intrauterine device and age \>45 years. * need for morcellation of the uterus
mechanisms of arm recovery in stroke patients with hand paralysis

Conditions: Stroke; Hemiparesis; Cerebral Vascular Accident; Stroke, Ischemic

Summary: this study examines the effect of non-invasive brain stimulation targeting different brain areas on movement of the affected arm post-stroke. participants will receive stimulation to each of 3 different brain areas combined with a session of arm exercise.

small improvements in affected arm movement can be made with intensive physical practice. these improvements could potentially be enhanced by combining non-invasive brain stimulation with practice. to develop such an intervention, it is necessary to understand which brain areas should be stimulated in which types of patients. it is probably more beneficial to target one side of the brain vs. the other, for example, depending on the characteristics of the stroke. this study will examine the effect of stimulating one side of the brain vs. the other on the amount of improvement that occurs from physically practicing functional arm movements.

Eligibility criteria:
inclusion criteria: * more than 6 months post-stroke * loss of voluntary finger movement in the affected hand * some voluntary movement of affected shoulder and/or elbow exclusion criteria: * brainstem or cerebellar stroke * severe cognitive or language deficits * epilepsy or other seizure disorder * central nervous system disease or disorder other than stroke

Keywords: arm rehabilitation non-invasive brain stimulation transcranial magnetic stimulation upper extremity
survey of testosterone levels in male cancer patients

Conditions: Hypogonadism

Summary: the purpose of this study is to survey the total serum testosterone levels in male patients with hormone-independent malignancies. the prevalence of hypogonadism is not known, but is thought to be significant. results will be adjusted for age and stratified for type of cancer, stage, study site,and presence of opiate use for pain management, which is known to reduce testosterone levels.

fatigue - extreme tiredness - is associated with cancer as well as its treatment. it has many causes, including the direct effects of the cancer itself, nutritional changes, anemia, changes in activity levels, worry, or, perhaps, hormones such as testosterone. this study is a survey of the amount of testosterone in the blood of men being treated for cancers that are not directly influenced by testosterone (not prostate or testicular tumors). testosterone is a hormone that is made by the body from teenage years through adulthood, and helps define male characteristics: sexual function, muscle building, ability to grow hair and deepen the voice. it is believed that the amount of fatigue experienced by men with cancer may be at least and in part due to reduced testosterone levels. male cancer patients will be recruited for this study at the time of regularly scheduled visits with their oncologists for treatment or for follow-up care. patients who agree to participate and sign a consent will be asked to answer questions about their health, medications, vitamins \& supplements, and to complete a standardized questionnaire about their quality of life. one tube of blood (8.5 cc) will be drawn at the same time as the other blood tests scheduled for that visit to avoid an additional blood draw. various elements of the collected information will be compared with the testosterone levels to see if any meaningful patterns exist. the study sample will be drawn from a geographically diverse set of oncology practices in the us. a larger follow-up study is planned if testosterone levels are found to be lower in men with cancer than similar age men without cancer, or if low testosterone levels are associated with more fatigue.

Eligibility criteria:
inclusion criteria: * age 18 or older * male cancer patients coming to oncology appointments for treatment or follow-up * must be able to answer questionnaire in english, alone or with assistance * informed consent exclusion criteria: * known hiv infection * known hypogonadism * testosterone or dhea supplementation within 3 months * prostate, breast, or testicular cancer

Keywords: male cancer
innate immunity and respiratory syncytial virus (rsv) infection in children

Conditions: Respiratory Syncytial Virus Infection

Summary: in this project we will study the capacity for single nucleotide polymorphisms (snp) in tlr4 gene to induce varying levels of inflammatory chemokine and cytokine production.

infection with rsv is the most common cause of respiratory tract illnesses (lris) in the first 3 years of life. there are significant social and health care costs associated with rsv-lris. more than 3% of us children are hospitalized each year due to rsv and 500 die annually. several longitudinal studies have also suggested that children who have rsv-lris are at substantially increased risk of developing asthma in the first 3 years after infection and bronchial hyperresponsiveness (bhr) many years after the primary infection. mechanisms involved in rsv disease are not well understood. recent reports suggest that rsv may initiate the innate immune response through the pattern recognition receptor, toll like receptor-4 (tlr4). in this project we will study the capacity for single nucleotide polymorphisms (snp) in tlr4 gene to induce varying levels of inflammatory chemokine and cytokine production. it has been suggested that such a mechanism may result in altered immune responses to rsv infection and different clinical outcomes. this research has direct application to improving our understanding of bronchiolitis in early childhood, particularly those factors that influence severity of the disease, and may have implications for possible therapy of patients with bronchiolitis in the future.

Eligibility criteria:
inclusion criteria: 1. parental or sibling history of asthma. 2. child must be less than 24 months of age. 3. presence of viral upper or lower respiratory tract symptoms. exclusion criteria: 1. history of recurrent wheezing requiring systemic corticosteroids. 2. prior history of lung disease. 3. birth \< 36 weeks gestation. 4. immunodeficiency 5. treatment with ribavirin, systemic or inhaled corticosteroids during the rsv infection. 6. congenital heart disease. 7. no history of parental or sibling asthma. 8. less than 48 hour or more than 5 day duration of viral uri symptoms since the peak symptoms from rsv would be expected to occur from 2-5 days into course of infection.

Keywords: rsv, asthma, innate immunity, gene, cytokines
the effect of edp on diaphragmatic function and neural respiratory drive in patient with aecopd

Conditions: Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is a common respiratory disease characterized by airflow limitation that is progressive and not fully reversible. patients with acute exacerbation of copd must be hospitalized, as for further increase in airway resistance, pulmonary alveolar excessive expansion, diaphragm fatigue and neural respiratory drive. in recent years, pulmonary rehabilitation is recognized as a core component in the comprehensive management of copd, edp as a means of rehabilitation can alleviate diaphragmatic fatigue, improve ventilation function, reduce the neural respiratory drive in patients with copd during hospitalization, but still lack of evidence based medicine. surface emgdi can accurately evaluate neural respiratory drive, its detection is non-invasive, simple and safety .therefore,neural respiratory drive by surface emgdi can be used as an important index for evaluating the therapeutic efficacy of aecopd patients during hospitalization. in the present study, about 40 patients with copd will be recruited as research subjects .and the investigators aim to explore the effect of edp on diaphragmatic function and neural respiratory drive in patient with aecopd.contrast analysis will be conducted to evaluate the effects of edp on patients with aecopd, which may provide a reasonable basis for the clinical application of edp to aecopd patients.

patients with aecopd will participate in a rehabilitation program for one week. participants in the proposed study will be randomly divided into two intervention groups:controlgroup and edp therapy group. before using edp,the investigators will measure the relevant parameters of lung volume , diaphragm electromyogram, diaphragm activity and other basline index. then edp will be applied to investigate the effects of edp on the above mentioned respiratory mechanics parameters.

Eligibility criteria:
inclusion criteria: * patients with pulmonary function test of forced expiratory volume at one second (fev1)/forced vital capacity(fvc) \< 70% after inhalation of bronchial dilation agent. * patients in a clinically acute exacebation state. exclusion criteria: * patients were excluded if they had evidence of pneumothorax or mediastinal emphysema and pacemaker installed. * patients with acute cardiovascular event and severe cor pulmonale. * patients with poor compliance. * an other causes of diaphragmatic dysfunction.

Keywords: aecopd edp neural respiratory drive surface emgdi
abcdef bundle to prevent delirium for copd patients

Conditions: Delirium; Copd; Nurse's Role

Summary: abstract chronic obstructive pulmonary disease (copd) is a progressive respiratory disorder characterized by persistent airflow limitation and chronic respiratory symptoms, resulting from abnormalities in the bronchi, bronchioles, and alveoli. patients with copd may require admission to intensive care units (icus), particularly during acute exacerbations. in this context, both disease management and the prevention of potential complications, such as delirium, are of critical importance. delirium is a common, preventable, and serious complication in icus that prolongs hospital stays, increases healthcare costs, and heightens the risk of infections. hypoxia-induced cognitive impairment is among the key contributing factors to delirium in patients with copd. to improve patient outcomes, the abcdef care bundle was introduced in 2013 as a structured and evidence-based approach to icu care. this study aims to evaluate the effectiveness of the abcdef care bundle in preventing delirium in patients with copd admitted to the icu. the research will be conducted as a randomized controlled trial between april and december 2025 in the third-level icu of taksim training and research hospital. the study population will consist of copd patients, with a total sample size of 84 patients (42 in each group), randomly assigned using a computer-assisted simple randomization method. a variety of validated instruments will be used to assess pain, sedation, cognitive status, mobility, and sleep quality. the findings of this study are expected to contribute to the growing body of evidence supporting structured icu care and to raise awareness among healthcare professionals regarding the implementation of the abcdef care bundle. keywords: abcdef care bundle, delirium, copd, intensive care, nursing care, randomized controlled trial


Eligibility criteria:
inclusion criteria: * patients aged 18 and over, * no cognitive disease such as dementia or alzheimer's, * patients requiring intensive care monitoring for at least 24 hours, * non-intubated patients, * having a diagnosis of copd. exclusion criteria: * patients being monitored in intensive care primarily due to central nervous system disease, * intubated patients.
effects of nebivolol on exercise tolerance and left ventricular systolic and diastolic function

Conditions: Hypertension

Summary: the goal of this pilot study is to effectively treat hypertension in subjects with either known or newly diagnosed hypertension and concurrent evidence of diastolic dysfunction. due to the unique properties of nebivolol, it is hypothesized that there will be improvements in left ventricular (lv) systolic and diastolic function manifesting as increase exercise capacity in this patient population with primarily lv diastolic dysfunction. the present study was performed to determine the effects of nebivolol on blood pressure, exercise tolerance and parameters of left ventricular systolic and diastolic function in a group of hypertensive patients with echocardiographic evidence diastolic dysfunction.

prior to the initiation of nebivolol and after 10 weeks of nebivolol therapy, subjects underwent a resting 2d echocardiogram including routine sampling of mitral valve (mv) inflow and lv tissue doppler imaging as well as a symptom limited exercise treadmill stress test with echocardiographic imaging. primary endpoints were 1) changes in systolic blood pressure before and after 10 weeks of treatment and 2) changes in exercise capacity as determined by exercise duration and metabolic equivalent (met) level before and after treatment. secondary endpoints were changes in exercise hemodynamics and doppler echocardiographic parameters of lv systolic and diastolic function and quality of life before and after 10 weeks of nebivolol treatment. subjects completed an euroqol (eq-sd) quality of life questionnaire which is a standardized measure of health status developed by the euroqol group as a simple general measure of health at baseline and at conclusion of the 10 week trial period.

Eligibility criteria:
inclusion criteria: * diagnosis (new or established) hypertension, defined by serial measurements \>/= 140/90 * evidence of diastolic dysfunction on echocardiography measured by tissue doppler exclusion criteria: * severe bronchospastic disease/ reactive airway disease * inability to tolerate beta blocker therapy including: \>1st degree atrioventricular (av) block, symptomatic hypotension, symptomatic bradycardia, * subjects with physical limitations that would prevent them from participating in an exercise treadmill test * age \ 90 years * those with life expectancy \<1 year * subjects with class iii/iv new york heart association (nyha) heart failure symptoms * chronic kidney disease 3 or greater (crcl \<30 cc/min) * subjects with active ischemia or evidence of ischemia on initial stress echocardiography

Keywords: diastolic function nebivolol
bipolar rfa using twin icw electrodes vs. switching monopolar rfa for recurrent hcc

Conditions: Hepatocellular Carcinoma

Summary: this study was conducted to provide preliminary data for the main trial to compare efficacy between bipolar radiofrequency ablation (rfa) using twin internally cooled-wet electrodes and switching monopolar rfa using separable clustered electrodes in the treatment of recurrent hepatocellular carcinoma (hcc) after locoregional treatment.


Eligibility criteria:
inclusion criteria: * radiologic or pathologic diagnosis of hcc recurrence after locoregional treatment * hcc nodules measuring 1 cm or larger and smaller than 5 cm exclusion criteria: * more than three hcc nodules * tumors with major vascular invasion or abutment to the central portal or hepatic vein with a diameter \> 5mm * extrahepatic metastasis * child-pugh class c * severe coagulopathy (platelet cell count of less than 50,000 cells/mm3 or prothrombin time international normalized ratio (pt-inr) prolongation of more than 50 %)

Keywords: rfa
a study of ins365 ophthalmic solution in patients with moderate to severe dry eye disease

Conditions: Dry Eye Disease

Summary: to evaluate the efficacy and safety of ins365 ophthalmic solution when applied topically in patients with moderate to severe dry eye disease.


Eligibility criteria:
inclusion criteria: * best corrected visual acuity of at least +0.7 etdrs * six month history of dry eye disease * mild severity in two out of five symptoms * unanesthetized schirmer score of less than or equal to 7mm * corneal fluorescein staining greater than or equal to 4 out of 15 or lissamine green conjunctival staining of greater than or equal to 5 out of 18 exclusion criteria: * nasal stimulated schirmer score of less than 3mm * have ongoing ocular infection * have congenitally absent meibomian or lacrimal glands * have had punctal occlusion within a specified time prior to study * wear contact lens and refuse to remove them * have other excluded eye conditions.