Kornimate/medical-research-clean huggingface dataset:
melatonin on coronary artery calcification

Conditions: Coronary Artery Calcification

Summary: we planned to evaluate the effects of melatonin on progression of coronary artery calcification (cac) in patients with moderate calcified coronary atherosclerosis.

cac is prevalent in coronary artery disease (chd), and the extent of cac predicts cardiovascular risk. the causes of cac include dysregulated matrix metabolism, epitaxial mineral deposition, inflammation, oxidative stress, and apoptosis. melatonin is the main indoleamine produced by the pineal gland; it is known recently to have anti-inflammatory, anti-cancer and antioxidant activities. several studies have shown that melatonin protects against inflammation and apoptosis in vascular calcification. melatonin also inhibits oxidative stress-induced apoptosis and calcification in endplate chondrocytes. the investigators planned to determine the efficacy of melatonin on progression of coronary artery calcification (cac) in patients with moderate calcified coronary atherosclerosis. this study may shed light as to whether oral melatonin supplementation can be an adjunct therapy in cac patients.

Eligibility criteria:
inclusion criteria: patients with a documented agatston score≥30 and moderate calcified coronary atherosclerosis (\<50% diameter lumen narrowing) were eligible for the study. exclusion criteria: 1. unstable angina pectoris 2. symptomatic chronic heart failure and/or left ventricular ejection fraction (ef) \<40% 3. atrial fibrillation or other arrhythmias 4. type i diabetes mellitus or uncontrolled type ii diabetes mellitus 5. renal failure 6. liver disease 7. gastrointestinal disease that affected absorption

Keywords: melatonin coronary artery calcification adjuvant therapy
prospective randomized trial between wbrt plus srs versus srs alone for 1-4 brain metastases

Conditions: Brain Metastasis

Summary: the purpose of this study is to determine if wbrt combined with srs resulted in improvements in survival, brain tumor control, functional preservation rate, and frequency of neurologic death.

whole-brain radiation therapy (wbrt) had been a mainstay in the treatment of brain metastases. however, treatment strategy which rely on stereotactic radiosurgery (srs) has becoming popular in japan. it is not well understood if the whole-brain radiation therapy (wbrt) combined with stereotactic radiosurgery (srs) resulted in improvements in survival, brain tumor control, functional preservation rate, and frequency of neurologic death. in orer to determine the role of wbrt, we conducted prospective randomized trial between wbrt+srs and srs-alone for 1-4 brain metastatic patients.

Eligibility criteria:
inclusion criteria: * 18 years of age or older with 1-4 brain metastases, each with a maximum diameter of no more than 3 cm on contrast-enhanced mri scans, and were derived from a histologically confirmed systemic cancer, karnofsky performance status (kps) score of 70 or more exclusion criteria: * patients with metastases from small cell carcinoma, lymphoma, germinoma, and multiple myeloma were excluded.

Keywords: whole brain radiation therapy stereotactic radiosurgery brain metastases
stop trial - sandostatin lar depot trial for the optimum prevention of chemotherapy induced diarrhea

Conditions: Neoplasms; Diarrhea

Summary: currently there is an ongoing clinical trial for patients with chemotherapy induced diarrhea. this trial is being conducted to evaluate the efficacy of two dose levels (30 mg and 40 mg) of an investigational drug in reducing the occurrence of severe (grade 3 or 4) diarrhea during chemotherapy. eligible patients must either have experienced nci common toxicity grade 1 - 4 chemotherapy-induced diarrhea during previous chemotherapy treatment or be experiencing grade 1-4 chemotherapy-induced diarrhea currently. in order to participate in this clinical trial, patients must be male or female 18 years of age or older. inclusion into this investigational drug trial is based on the protocol entry criteria and a detailed evaluation from a participating trial investigator


Eligibility criteria:
key inclusion criteria: * male or female patients of 18 years of age or older, scheduled or expected to receive at least two cycles of chemotherapy over at least a two- month period as primary or adjuvant therapy for any malignancy, * have experienced nci common toxicity grade 1 - 4 diarrhea during previous chemotherapy treatment or are currently experiencing grade 1-4 diarrhea due to chemotherapy treatment key exclusion criteria: * females who are pregnant or lactating, * current use of anticoagulants, except for those who are receiving 1 mg/per day of coumadin for port maintenance, * known hypersensitivity to sandostatin, sandostatin lar ® depot or other related drug or compound, * history or presence of crohn™s disease, ulcerative colitis, sprue, or known c. difficile infection, or any other diarrheal syndrome, * wbc \ 2.0 mg/dl

Keywords: chemotherapy induced diarrhea diarrhea ctid colorectal cancer sandostatin lar depot sandostatin adverse events side effects
cbt for patients with attention deficit hyperactivity disorder (adhd) and substance use disorders

Conditions: Attention Deficit Hyperactivity Disorder; Substance Use Disorders

Summary: the purpose of this study is to determine if cognitive behavioral therapy is effective in treating adhd symptoms in patients with substance use disorders and comorbid adhd.

attention deficit hyperactivity disorder(adhd) is an important comorbid condition in patients with substance use disorders (sud). the prevalence of adhd in patients with sud is estimated 23%, and adhd is associated with an untoward prognosis of sud. however, adequate treatment programs for patients with adhd and sud are not available. results of medication trials for patients with adhd and sud are disappointing, and cognitive behavioral therapy (cbt) has not yet been investigated in this population. in patients with adhd without comorbid sud, the results of cbt in randomized trials are positive. the purpose of this study is to investigate if cbt is effective in treating adhd symptoms in patients with adhd and sud.

Eligibility criteria:
inclusion criteria: * substance use disorder * adhd * able to comply with study activities exclusion criteria: * severe neurological or psychiatric diseases (for example parkinson, dementia, psychosis, bipolar depression) which require medication * unable to read or write dutch language

Keywords: adhd sud cognitive behavioral therapy
follow-up of covid-19 vaccine response in strasbourg university hospitals

Conditions: COVID-19 Vaccines

Summary: vaccination remains the main promising measure to fight against the covid-19 pandemic. the presumed efficacy of the vaccines is quite remarkable since it varies between 62 and 95%. there is increasing evidence that sex-specific effects may lead to different outcomes of vaccine safety and efficacy. however, sex-disaggregated data after covid-19 vaccine are lacking. the first purpose of the study is to determine antibody titers against sars-cov-2 spike after covid-19 vaccination. the secondary purpose is to identify predictor factors of immune response including age, gender and biological factors.


Eligibility criteria:
inclusion criteria: - any person, male or female, over 18 years of age who underwent vaccination and * anti-sars-cov-2 serological test after vaccination * having already given their consent for their biological resources to be: * stored in a biocollection of the microbiology technical platform (ptm) having received an approval from the cpp est-iv and declared to the ministry of education and research under reference no. dc2009-1002; * subsequently reused, as well as the anonymized associated data, for research purposes exclusion criteria: * inability to give clear information (person in an emergency, difficulty understanding the subject, etc.) * person under safeguard of justice * person under guardianship or curatorship-

Keywords: covid-19 sars-cov-2 vaccine humoral response anti-spike antibodies neutralizing antibodies gender
a safety and efficacy of homeopathic medicine rhus toxicodendron 30 in the treatment of rheumatoid arthritis

Conditions: Rheumatoid Arthritis.

Summary: the purpose of the study is to assess the safety and efficacy of commonly used homeopathic medicine rhustoxicodendron in 30 potency in the treatment of rheumatoid arthritis.

it is a multicenter phase 2 ,double blind study in patient with active rheumatoid arthritis ,there are 2 group in the study a and b ,where group a receive rhustoxicodendron in 30 potency the first dose will administered orally (1/2 ml)after the completion of case taking ,and repeated every 7th day for 5 month and on the other hand group b receive placebo orally in (1/2 ml) at same interval for same period .

Eligibility criteria:
inclusion criteria: * those who will provide written consent to participate in the study * patient willing to turn up for 7th day follow up * patient who are willing and compliance to the study * those who are between 25 to 60 years . * patient who are willing and compliance to the study . * esr more then 28 mm. exclusion criteria: * participating as a subject in any other clinical research study. * children below the age of 25years. * female subject who are pregnant or planning for pregnancy within 6 month. * history of seizures * breast feeding women's. * patient on treatment for life threatening illness like cancer aids etc. * patient should not have any congenital abnormality or patient should not have undergone any operative procedure as consequences of ra.

Keywords: ra
functional mri study of vibrotactile stimulation effects in fibromyalgia

Conditions: Fibromyalgia

Summary: the purpose of this study is to investigate the effects of low-intensity and prolonged vibrotactile sensory stimulation on brain activity and functional connectivity in fibromyalgia patients.


Eligibility criteria:
inclusion criteria: 1. a diagnosis of fibromyalgia according to the american college of rheumatology (acr) (arthritis care res 2010;62:600-10). 2. clinical symptoms are not a consequence of other medical disorder (although the presence of other disorders is not an exclusion criterion) 3. diagnoses established by an expert on fibromyalgia. 4. stable treatment of chronic use. 5. subject demonstrates an understanding of the study and a willingness to participate as evidenced by voluntary written informed consent. exclusion criteria: 1. generalized inflammatory articular or rheumatic disease. 2. severe, non-stable medical, endocrinological or neurological disorder. 3. psychotic disorder or drug abuse.
modeling the impact of inbound call distribution virtualization in emergency medical communication centers (emccs) on their service level

Conditions: Emergency Medical Service Communication Systems, Health Care

Summary: fast access to the emergency medical communication center (emcc) is essential for the population in emergency situation. it is therefore essential that these call centers operate quickly and provide good quality service. however, in recent years, emccs have experienced a constant and increasing demand from the population. thus, maintaining the current organization of emergency medical communication centers raises questions about both the volume of incoming calls to emccs and the economic constraints, which make it difficult to manage call peaks, especially in periods of crisis. the aim of our study is to assess the impact of incoming call distribution virtualization in emccs on their service quality.

france is facing political decisions on the evolution of emergency medical communication center organization to improve population accessibility. regarding the performance targets requested by the french government (marcus report: http://www.urgences113.fr/marcus/rapport_marcus3.pdf), the virtualization of inbound call distribution could improve emcc service quality indicators. the virtualization is a process that consists of centralizing calls from different territories before distributing them to the centers concerned according to their availability. the objective through this process is to improve the population' access to the emcc by reducing waits time. and on the other hand, to optimize the activity rate of dispatchers and physicians.

Eligibility criteria:
inclusion criteria: * all incoming calls passing through the five emergency medical centers in the pays de la loire region (loire-atlantique, maine-et-loire, mayenne, sarthe and vendée). in each center, an advanced telephone system automatically keeps track of all inbound calls. exclusion criteria: according to the french national consortium, incoming calls that hung up in less than 10 seconds are considered as dialing errors and are excluded

Keywords: emergency health service, accessibility, virtualization, organization
promoting hiv self-testing among msm during covid-19 pandemic

Conditions: Health Behavior

Summary: a community-based organization (cbo) recruited chinese-speaking men who have sex with men who are hiv-negative or unknown sero-status through multiple channels in hong kong, china. participants first complete a baseline telephone survey, and then receive the following health promotion components: 1) viewing an online video promoting hivst, 2) visiting the project webpage containing demonstration video of how to use hivst kits, information about local hiv epidemic and benefits of hiv testing and hivst, and a discussion forum containing positive feedback of hivst users, and 3) having access to a chargeable hivst services implemented by the cbo. all participants are invited to complete a follow-up telephone survey six months after completion of the baseline survey.


Eligibility criteria:
inclusion criteria: * aged 18 years or above * having access to internet * anal intercourse with at least one man in the past six months * willing to complete telephone follow-up survey at month 6 exclusion criteria: * self-reported to be hiv positive

Keywords: hiv testing hiv self-testing
the effectiveness of different techniques of interscalene brachial plexus block with general anesthesia for shoulder arthroscopy

Conditions: Shoulder and Upper Arm Injury

Summary: there are different techniques of interscalene brachial plexus block, we aimed to evaluate the effectiveness of 3 of them as analgesia during shoulder arthroscopy surgery under general anesthesia.

prospective randomized controlled study there were 4 groups included in our study: group n: nerve stimulator guided interscalene brachial plexus block was done group u: ultrasound guided interscalene brachial plexus block was done group nu: dual guidance (using both nerve stimulator and ultrasound) group c: control group we assessed in each group: heart rate, noninvasive blood pressure, time needed for block, onset of sensory and motor power loss and their offset, and finally patient satisfaction.

Eligibility criteria:
inclusion criteria: * age: 18-65 years old. * sex: both sexes. * asa i \& ii. exclusion criteria: * - patient refusal. * bleeding disorders. * damage or disease of the brachial plexus. * asa more than ii. * pre-existing peripheral neuropathy. * patients with neuromuscular diseases. * patients with known hypersensitivity to drugs of the study. * patients with local skin infection at the site of injection. * psychiatric diseases interfering with evaluation of the block.

Keywords: shoulder arthroscopy
comparison of lstr and pulpectomy in primary molars of pediatric patients (lstr-pulp)

Conditions: Pulpal Necrosis; Dental Caries; Periapical Periodontitis; Pediatric Dentistry; Primary Tooth Pulpectomy

Summary: this study aims to compare the effectiveness of lesion sterilization and tissue repair (lstr) with conventional pulpectomy in treating pulpal lesions in primary molars of pediatric patients aged 4 to 10 years. lstr is a minimally invasive method that uses antibiotic paste to disinfect infected tissue without full canal instrumentation. children participating in this study will receive either the lstr technique or standard pulpectomy, and the clinical and radiographic success of both treatments will be evaluated over a 12-month period. the goal is to determine whether lstr is a safe and effective alternative to pulpectomy in primary teeth.

this is a prospective, clinical trial conducted at atatürk university, department of pediatric dentistry. the study compares two endodontic treatment methods for primary molars with pulpal lesions in children aged 4 to 10 years. a total of 108 primary molars will be assigned to two groups: the experimental group receiving lesion sterilization and tissue repair (lstr) and the control group receiving conventional pulpectomy. the lstr group will be treated with a combination of ciprofloxacin and metronidazole antibiotics mixed with iodoform-calcium hydroxide paste, while the pulpectomy group will receive standard chemomechanical canal debridement and obturation with iodoform-calcium hydroxide paste. each treatment will be followed by restoration using either compomer or stainless steel crown, depending on patient cooperation and clinical setting. patients will be followed up clinically at 3, 6, and 12 months and radiographically at 6 and 12 months. treatment success will be evaluated based on the resolution of clinical symptoms and radiographic healing, using the periapical index (pai) and observation of root resorption patterns. the primary objective is to assess whether the lstr technique achieves similar or superior success rates compared to pulpectomy in terms of both clinical outcomes and radiographic healing.

Eligibility criteria:
inclusion criteria: * children aged 4 to 10 years. * presence of at least one primary molar with pulpal involvement requiring endodontic treatment. * good general health without systemic conditions. * signed informed consent from parent or legal guardian. exclusion criteria: * children with systemic diseases or immune-compromising conditions. * known allergies to any of the materials or antibiotics used in the study. * uncooperative behavior preventing dental treatment under normal clinical conditions. * teeth with non-restorable crown structure or excessive root resorption.

Keywords: lstr pulpectomy primary teeth triple antibiotic paste
a randomized, double-blind study of the efficacy and safety of valdecoxib compared to placebo for treatment of post- cholecystectomy surgery pain

Conditions: Laparoscopic Cholecystectomy; Pain

Summary: to evaluate the analgesic efficacy, general safety, and effects on health outcome measures and opioid-related symptoms of 2 valdecoxib dosing regimens compared with placebo in patients with moderate or severe pain following laparoscopic cholecystectomy surgery.


Eligibility criteria:
inclusion criteria: * patients had required an elective, non-urgent laparoscopic cholecystectomy, as an outpatient procedure, with asa class i-iii, with a baseline pain intensity of moderate or severe on a categorical scale and ≥45 mm on a vas (100 mm) * patients were able to get their first dose of study medication within 8 hours after the end of surgery exclusion criteria: * patients could not undergo procedures expected to produce a greater degree of surgical trauma than the laparoscopic cholecystectomy alone, nor have acute pre-operative pain (other than biliary colic) nor chronic pain conditions, nor uncontrolled chronic conditions, nor cancer, nor a laboratory abnormality that the investigator considered to contraindicate study participation * patient had any cognitive impairment that would, in the investigator's opinion, preclude study participation or compliance with protocol mandated procedures * patient had a history of known alcohol, analgesic, or narcotic substance abuse within the one year prior to screening * patient had any laboratory abnormality at screening, that, in the opinion of the investigator, is not due to the condition requiring surgery and is not expected to resolve post-surgery, and would, therefore, contraindicate study participation

Keywords: laparoscopic cholecystectomy surgery, acute pain, perioperative pain
increasing physical activity through personalised motivational messaging to improve cognitive function in lung cancer survivors

Conditions: Neoplasms; Lung Cancer; Physical Inactivity; Cognitive Impairment

Summary: objectives: to examine the effectiveness of a personalised motivational messaging intervention for improving cognitive function in lung cancer survivors. hypothesis to be tested: lung cancer survivors receiving personalised motivational messaging will have better cognitive function than usual care. design and subjects: a randomised controlled trial in 196 lung cancer survivors with cancer-related cognitive impairment. intervention: the intervention group will be equipped with a wearable activity tracker for 3 months and receive personalised motivational messages via instant messaging applications (e.g., whatsapp) to promote physical exercise. the intervention will include 1) regular messages sent at preferred times and frequencies allowing participants to choose suggested physical activity goals, and 2) support via chat-type messaging such as goal setting, real-time counselling, and practical advice. the control group will receive a leaflet on cognitive impairment with reminder text messages for follow-up surveys. main outcome measures: data will be conducted at baseline (t0), 3 months (t1; immediately after intervention delivery), and 6 months (t2; long-term follow up). primary outcome will be cognitive function measured by hk-moca (objective) and functional assessment of cancer therapy-cognitive function (fact-cog) scale (subjective). secondary outcomes are physical activity (ipaq-sf), self-efficacy for exercise (see), psychological well-being (phq-4), and quality of life (eortc qlq-c30). data analysis: intention-to-treat, post-trial qualitative (compliance with the intervention), and cost-effectiveness analyses will be conducted. we will follow the consort-ehealth checklist. expected results: this trial will provide evidence on the effectiveness of the proposed intervention on improving cognitive function and increasing physical activity among lung cancer survivors.


Eligibility criteria:
inclusion criteria: 1. aged ≥ 18 years; 2. diagnosed with stage i-iii non-metastatic nsclc cancer; 3. completed primary treatment with curative intent (surgery, chemotherapy and/or radiation therapy) 6 months to 5 years prior to the baseline assessment with no recurrence or occurrence of additional cancers; 4. identified as having mild cognitive impairment by the hk-moca 5-min protocol (≤ 7th age- and education-corrected percentile cut-off score); 5. not engaged in regular exercise (defined as \< 150 min of moderate-intensity exercise per week). exclusion criteria: 1. inadequate reading and verbal cantonese comprehension for the study activities; 2. diagnosed with dementia; 3. unable to use mobile phone text messaging applications (e.g., whatsapp).
interferon alpha lozenges plus oseltamivir for influenza treatment

Conditions: Influenza A Virus Infection

Summary: this study aims to evaluate the safety and effect of interferon-alpha lozenges when used in combination with oseltamivir (tamiflu) to treat influenza.


Eligibility criteria:
inclusion criteria: * fever \>=38c * one or more respiratory symptoms (e.g. cough, rhinorrhea or sore throat) plus one or more constitutional symptoms (e.g. chills, headache, malaise and myalgias)of \< 48 hours' duration * body weight \> 40 kg * positive for influenza a (nasal swab rapid test) exclusion criteria: * pregnancy/lactation * history of depression or psychiatric disorders * history of conditions that could complicate flu infection, such as chronic pulmonary, cardiac, renal, or metabolic disorders * use of immunosuppressive therapy * hiv infection

Keywords: interferon-alpha oseltamivir drug therapy, combination influenza therapies, investigational