Kornimate/medical-research-clean huggingface dataset:
magnetic brain stimulation in the treatment of mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: this is a pilot study to test the efficacy of repetitive transcranial magnetic stimulation (rtms) on cognitive improvement in individuals with mild cognitive impairment (mci). the main objective of this study is to investigate the ability of rtms to produce cognitive improvement in individuals with mci. a secondary objective is to determine whether individuals with mci following mild brain trauma respond differently to rtms treatment compared to individuals with non-trauma related mci. participants will undergo both active and sham (placebo) rtms treatment. cognitive and psychological assessments will be administered before and after each week of rtms therapy, for both active and sham conditions. cognitive testing will include verbal, semantic, logic, visual, conceptual, and memory tasks.

this is an open-label pilot study to test the efficacy of repetitive transcranial magnetic stimulation (rtms) on cognitive improvement in individuals with mild cognitive impairment (mci). 16 patients with trauma-related mci and 16 patients with non-trauma-related mci will be recruited. all patients will undergo one week of active rtms stimulation and one week of sham stimulation, separated by at least one week. each treatment week will consist of five consecutive daily stimulation sessions. the order of active versus sham treatment sessions will be counterbalanced across subjects within each group (i.e., half of the subjects in each group will receive active stimulation first and half will receive sham first). cognitive and psychological assessments will be administered before and after each week of rtms therapy, for both active and sham conditions. additional participants (n=32; 16 without tbi) will be recruited who are receiving a full course (30 sessions) of active rtms treatment (without a sham intervention). these participants will complete the same cognitive testing as the sham-crossover group at three time-points: pre-treatment, mid-treatment (after session 16), and post-treatment (after session 30).

Eligibility criteria:
inclusion criteria: * adults presenting with mild cognitive impairment (trauma and non-trauma related) exclusion criteria: * history of a psychotic episode * history of neurological illness * active alcohol or substance abuse * history of seizure disorder * currently pregnant
effect of a single colecalciferol dose on insulin resistance

Conditions: Insulin Resistance; Glucose Intolerance

Summary: a prospective double-blinded, placebo controlled, randomized trial comparing a single dose of vitamin d (colecalciferol) 300.00ui to placebo on patients with insulin resistance. primary outcome: blood glucose and homeostasis model assessment for insulin resistance (homa-r) after 90 days. study hypothesis: vitamin d treatment may improve insulin resistance and decrease glucose level, since there is an association between hypovitaminosis d and increased insulin resistance.


Eligibility criteria:
inclusion criteria: * fasten blood glucose \> 100 mg/dl and \< 126 mg/dl * age \> 18 years exclusion criteria: * diabetes mellitus * use of metformin * vitamin d use * hypercalcemia * chronic hepatitis * hiv
incidence of bacteremia following argon plasma coagulation in patients with endobronchial lesions

Conditions: Bacteremia

Summary: incidence of bacteremia following argon plasma coagulation in patients with endobronchial lesions

bacteremia is a well-recognized invasive medical condition. in most cases, it is a transient phenomenon without clinical consequences. in certain patients, such as those with structural cardiac abnormalities, it may lead to the development of infectious endocarditis. according to an american heart association statement, routine endocarditis prophylaxis is indicated prior to invasive procedures with relatively high bacteremia rates, such as dental care,certain types of catheterization and rigid bronchoscopy \[1\].fibreoptic bronchoscopy, with or without biopsy is not included in this list due to a very low bacteremia rate \[1\].this even applies to particularly high risk patients with prosthetic valve or previous endocarditis. yigla et al. assessed the incidence of bacteremia following bronchoscopy and found 6.5% of bacteremia rate. (2) recently, steinfort et al. assessed the bacteremia rate following endobronchial ultrasound and found 7% of bacteremia rate following the procedure. all bacterial isolates were typical oropharyngeal commensal organisms. the transbronchial needle aspiration washing culture was positive in 35% of the patients. however, none of the bacteremic patients had clinical features suggestive of infection and no complications were seen among the cohort. (3) no data are available, however about the bacteremic rate following interventional bronchoscopy for endobronchial obstruction and advance lung carcinoma. in these cases, palliative setting of alleviating central airway obstruction, laser resection, electrocautery, argon plasma coagulation and stenting are techniques that can provide immediate relief. argon plasma coagulation (apc) is uses ionize argon gas jet flow to conduct electrons allowing a noncontact mode of treatment (lightning effect). (4, 5) apc has been popular in gastrointestinal endoscopy for superficial coagulation of large mucosal surfaces. the argon gas quite flexibly flows around bends and corners. coagulated tissue has a higher resistance that automatically drives the argon gas flow away to nearby untreated tissue. an immediate effect really can be seen during electrocautery treatment, which corresponds well with the histological effect of coagulative necrosis. we therefore conduct a prospective study to assess the bacteremic rate following apc in patients with endobronchial involvement.

Eligibility criteria:
inclusion criteria: * all patients that undergo bronchoscopy with the use of apc exclusion criteria: * all patients under 18 years old all patients with evidence of current respiratory infection or febrile illnesses and those that will receive antibiotic therapy within a week prior to the bronchoscopy

Keywords: bacteremia argon plasma coagulation endobronchial lesions
pain self-management program for older adults

Conditions: Chronic Pain; Depression; Anxiety

Summary: it is well documented that severe pain is more common in older adults than it is younger persons. of concern, older adults may not have access to traditional face-to-face self-management programs, which are recognized to be valuable in chronic pain management. access to effective self-management approaches is particularly important for older adults who may have mobility limitations or live in remote areas, or have difficulty accessing health care services. the development of effective pain self-management programs for older adults who cannot access traditional psychological interventions is of significant importance. internet self-management programs have the potential to address pain undermanagement. as technology advances, the digital divide between the older and younger demographic continues to progress. given the known difficulties with treatment access, the purpose of this study is to explore the efficacy and acceptability of a remotely-delivered chronic pain self-management program tailored to older adults, the pain course, when delivered in online and workbook formats. the program was previously shown to be effective among younger persons but has not been tested with older adults.

the program is delivered through a secure platform administered by the online therapy unit for service education and research at the university of regina. using a patient preference randomized control trial (rct) design, participants (n = 120) will be enrolled in either the online group or workbook group, or to a wait list control group. the content of both programs will be identical and contain 5 core lessons, which participants will be encouraged to work through over an 8-week period. by exploring the efficacy of an online vs. workbook group, the results from this study may serve as a stepping-stone for improved self-management of chronic pain in older adults. a patient preference randomized controlled trial (rct) was chosen for this study. the goal is to have most participants accept randomization by emphasizing they are equally acceptable, so only those with a very strong preference or no access to internet aren't randomized. according to the preliminary power analysis, a total of 120 participants will be randomly assigned to be enrolled in the online group or workbook group, or be placed on a twelve-week wait list control, which will serve as a control group to control for the influence of time on symptom change between groups.

Eligibility criteria:
inclusion criteria: * are residents of canada * are 65 years of age or older * report experiencing pain for more than three months * are not experiencing very severe symptoms of depression or anxiety * have regular access to a computer and the internet * are proficient in writing and speaking the english language exclusion criteria: * high suicide risk * concerns about online therapy * not present in the country during treatment * are younger than 65 years of age

Keywords: chronic pain pain self-management remote delivery workbook online
using of testes shocker in improving the spermatogenesis and sperms activity

Conditions: Infertility, Male; Infertility Unexplained; Infertility Due to Complete Spermatogenic Arrest; Oligospermia; Asthenozoospermia; Necrospermia

Summary: infertility was reported in approximately 15% of all heterozygous couples, with male factor accounting for nearly half the cases. this typically occurs due to low sperm production, sperm dysfunction, and sperm delivery obstruction. etiology of male infertility can be attributed to many factors including acute or chronic illness, accidents, and lifestyle choices.

this study demonstrated that using a painless, convenient at-home device could significantly improve sperm motility and count. this device can be utilized to tackle (for unexplained infertility) the significant issue of infertility in a cost-effective, safe and efficacious.

Eligibility criteria:
inclusion criteria: * infertile male with oligosperma, necrospermia, asthenozoospermia or hypospermia. must not taking any drugs or medications for infertility and has nit any congenital diseases in the genital tracts or chronic diseases. exclusion criteria: * have congenial genital tract disease, has a chrome disease, has other than the above mentioned causes for infertility or taking medications that can affect the fertility.

Keywords: infertility testes shocker electric shocks
effects of administration of fostamatinib on blood concentrations of warfarin in healthy subjects

Conditions: Rheumatoid Arthritis; Healthy Subjects

Summary: the purpose of this study is to determine whether fostamatinib influences the plasma concentration of warfarin and changes its blood thinning effect, and to investigate how safe and tolerable it is when administered with warfarin.


Eligibility criteria:
inclusion criteria: * provision of informed consent prior to any study specific procedures (including genotyping screening sample for cyp2c9 and vkorc1). * males or females (of non-childbearing potential) aged 18 to 55 years (inclusive) * subjects must be negative for occult blood (stool card) prior to administration. * body weight of at least 50 kg and body mass index (bmi) between 18 and 35 kg/m2 inclusive exclusion criteria: * history of any clinically significant disease or disorder which, in the opinion of the investigator, may put the subject at risk because of participation in the study, or influence the results of the study. * healthy subject predicted to be most sensitive to warfarin based on cyp2c9 and vkorc1 genotypes. * a protein c and/or protein s deficiency. * absolute neutrophil count of less than 2500/mm3 or 2.5 x 109/l * previous treatment with warfarin for a clinical indication (ie, participation in a previous warfarin interaction study is acceptable).

Keywords: drug-drug interaction phase 1 healthy subjects warfarin rheumatoid arthritis ra fostamatinib open-label pharmacokinetics pharmacodynamics level of warfarin in the blood
study in adults and adolescents with seasonal allergic rhinitis

Conditions: Hayfever; Rhinitis, Allergic, Seasonal; Seasonal Allergic Rhinitis

Summary: the purpose of the study is to compare the efficacy and safety of an investigational nasal spray compared with placebo nasal spray in the treatment of seasonal allergic rhinitis. allergic rhinitis is an inflammatory disorder of the upper airway that occurs following allergen exposure. the focus of this study, seasonal allergic rhinitis (sar), is one type of allergic rhinitis that is triggered by the pollen from trees, grasses, and weeds. commonly referred to as "hay fever", it is characterized by sneezing, nasal congestion and pruritus, rhinorrhea, and pruritic, watery, red eyes.


Eligibility criteria:
inclusion criteria: * informed consent. * outpatient. * females must use appropriate contraception. * diagnosis of seasonal allergic rhinitis. * adequate exposure to allergen. * able to comply with study procedures. * literate. exclusion criteria: * significant concomitant medical condition. * use of corticosteroids, allergy medications, or tobacco. * clinically significant abnormal ecg. * laboratory abnormality. * positive pregnancy test. * allergy to any component of the investigational product.

Keywords: gw685698x once daily mountain cedar allergic rhinitis fluticasone furoate
90% effective dose of phenylephrine infusions under intensive and standard treatment

Conditions: Adverse Effect

Summary: the objective of this study is to investigate the 90% effective dose of phenylephrine infusions for preventing postspinal anesthesia hypotension under intensive and standard treatment during cesarean section

post-spinal anesthesia hypotension is a frequent complication during spinal anesthesia for cesarean section. the incidence of post-spinal anesthesia hypotension is as high as 62.1-89.7% if prophylactic measures are not taken. the 2016 asa guidelines for obstetric anesthesia suggest avoiding hypotension following spinal anesthesia in women and emphasize the use of vasopressors, specifically alpha-receptor agonists, as the preferred strategy to prevent and manage post-spinal anesthesia hypotension. the 2018 international consensus in the united kingdom and northern ireland recommends maintaining maternal systolic blood pressure above 90% of the baseline value following lumbar anesthesia, while avoiding dropping below 80% of the baseline value. currently, the threshold for maintaining blood pressure above 80% of the baseline value is widely adopted as a standard; however, limited evidence supports the advantage of sustaining maternal blood pressure above 90% of the baseline value. the objective of this study is to investigate the 90% effective dose of phenylephrine infusions for preventing postspinal anesthesia hypotension under intensive and standard treatment during cesarean section.

Eligibility criteria:
inclusion criteria: * 18-45 years * primipara or multipara * singleton pregnancy ≥37 weeks * american society of anesthesiologists physical status classification i to ii * scheduled for cesarean section under spinal anesthesia exclusion criteria: * body height \< 150 cm * body weight \> 100 kg or body mass index (bmi) ≥ 40 kg/m2 * eclampsia or chronic hypertension or baseline blood pressure ≥180 mmhg * hemoglobin \< 7g/dl
acupuncture in cardiovascular disease

Conditions: Congestive Heart Failure

Summary: the purpose of this study is to determine if acupuncture decreases adrenaline levels in heart failure, thereby potentially improving survival and quality of life.

acupuncture is used to lower blood pressure in patients with hypertension, and to relieve angina in patients with coronary artery disease. while the biological mechanisms of acupuncture analgesia have been studied intensely in animals and humans, the biological mechanisms for modulation of the cardiovascular system in humans remain largely unexplored. acupuncture at traditional acupoints, and at nonacupoints, decreases the blood pressure response during mental stress in normal humans. this depressor effect cannot be fully explained by a decline in muscle sympathetic nerve activity (msna). further, in humans with heart failure (hf) in whom msna is elevated, we have preliminary data that acupuncture significantly decreases the msna response during mental stress. the following hypotheses will be tested: 1) acupuncture, performed at traditional acupoints and non-acupoints in normal humans, stimulates skeletal muscle afferent neurons causing a release of endogenous opioids, which oppose sympathetic excitation and vasoconstriction in visceral vascular beds, such as the kidney; 2) in humans with hf in whom msna is elevated and renal vasoconstriction is the rule, acupuncture utilizes similar mechanisms as in normal humans to produce exaggerated inhibition of msna and reflex renal vasoconstriction. positron emission tomography and microneurography will be utilized to answer the following questions in normal humans and patients with heart failure: 1. is acupuncture attenuation of bp during mental stress mediated by a decrease in renal vasoconstriction? 2. is acupuncture sympathoinhibitory? 3. is acupuncture modulation of the autonomic nervous system mediated by muscle afferents? 4. is acupuncture modulation of the autonomic nervous system mediated by activation of endogenous opioids? understanding the mechanisms of acupuncture modulation of the autonomic nervous system in humans may help clarify its role as a therapeutic modality in cardiovascular diseases, such as heart failure.

Eligibility criteria:
* chronic congestive heart failure class ii-iii * no unstable angina * no myocardial infarction within 3 months * no peripheral neuropathy

Keywords: acupuncture heart failure autonomic nervous system
adapted physical activity education in patients with neurocognitive disorder

Conditions: Neurocognitive Disorders

Summary: this study aims to compare the effect of a program of adapted physical activity (apa) versus the same program combined with a physical activity education program (pae). patients suffering from neurocognitive disorders (mild or early major) will be randomized into one of the two conditions. 3 complete evaluations will be done (inclusion m0, after 3 month of intervention m3, 3 months after the end of the intervention m6). the team except that apa+pea will be more effectiv than the apa solely, on the following criteria : level of physical activity, cogntive function and quality of life.


Eligibility criteria:
inclusion criteria: * mild neurocognitive disorder or early major neurocognitive disorder exclusion criteria: * medical pathology involving the vital prognosis in the short term * major neurocognitive disorder at moderate stage and beyond (dsm 5) and/or mmse \< 20 * unbalanced depressive syndrom * contraindication to the practice of the exercises proposed during the study; * major hearing or visual impairment; * sufficiently active with regard to the daily recommendations described by the who
the effects of aerobic exercise training on vascular, cardiac and cerebral vascular function in copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the primary cause of chronic obstructive pulmonary disease is smoking, which can lead to inflammation in the lungs and blood vessels that can lead to secondary problems such as blood vessel disease, high blood pressure and heart disease. aerobic exercise training has been shown to reduce the risk of heart and brain disease; however, it is currently unknown whether exercise training can have the same affect in patients with copd. the aim of this study is to investigate how eight weeks of aerobic exercise training improves blood vessel and heart function and brain blood flow in patients with copd.

chronic obstructive pulmonary disease (copd) is a treatable respiratory condition that is only partially reversible. the primary cause of copd is smoking which leads to airway inflammation and oxidative damage to the lungs, which has been linked to the development and progression of the disease. the inflammation is not isolated to the lungs as patients with copd also have systemic inflammation that has been linked to a number of cardiovascular comorbidities such as endothelial dysfunction, cardiovascular disease and stroke. evidence demonstrates that copd patients have a greater incidence of vascular dysfunction and adverse vascular remodeling, which worsens with disease severity. in fact, patients with copd are at 35 times greater risk of developing cardiovascular disease and stroke than healthy aged matched individuals. in healthy individuals and a number of chronic conditions, aerobic exercise training is well established to reduce the risk of cardiovascular and cerebrovascular disease. the benefits of exercise are likely through improvements in endothelial function, systemic inflammation, and cardiac and cerebral vascular function. however, whether exercise training can have the same effects in a chronic inflammatory condition like copd has not been studied. the purpose of this study is to determine the effectiveness of an 8 week aerobic exercise training program in patient's chronic obstructive pulmonary disease as determined by improvements in endothelial function, systemic inflammation and cardiac and cerebral vascular function.

Eligibility criteria:
inclusion criteria: * non-smokers (\>6 months); * forced expiratory volume in one second/ forced vital capacity (fev1/fvc) \< 0.7 and fev1/fvc \<lower limit of normal * stable (\>3 months exacerbation free) exclusion criteria: * on supplemental oxygen; * known cardiac or cerebral vascular disease, diabetes, obstructive sleep apnea; * uncontrolled hypertension; * bmi \>30kg/m2 * currently performing pulmonary rehabilitation or structured exercise training; * desaturate during exercise (spo2\<85%) * cardiovascular contraindications to exercise in the incremental test used for screening

Keywords: copd exercise training flow-mediated dilation arterial stiffness echocardiography cerebrovascular physiology
rpe characterisation with transscleral optical phase imaging in retinal disorders

Conditions: Retinal Disease; Eye Disease

Summary: accumulating evidence suggest that the functional unit of photoreceptor/ retinal pigment epithelium (rpe)/bruch's membrane/choriocapillaris plays a key role in pathophysiologic processes of a wide range of medical retinal disorders of the eye. little is known about in vivo morphometric characteristics of human rpe cells as in vivo observation of these cells was so far technically challenging and hence nearly impossible to implement in a clinical setting. transscleral optical phase imaging is a novel in-vivo microscopy technique allowing human rpe imaging on a cellular level with the potential of clinical application in a multimodal retinal imaging approach for diagnostic purpose in medical retina patients.


Eligibility criteria:
inclusion criteria: * informed consent as documented by signature (appendix informed consent form) * patients with a medical retinal disease involving the retinal pigment epithelium (age related macular degeneration, diabetic retinopathy, retinal vascular occlusive disease, central serous chorioretinopathy, tapetoretinal degeneration) * participants with healthy eyes for the control group exclusion criteria: * inability to follow the procedures of the study due to language problems, psychological disorders, dementia etc. of the participant * aged \< 18 years. * pregnancy * epilepsy