Kornimate/medical-research-clean huggingface dataset:
sulfur colloid spect/ct in measuring liver function in patients with primary or metastatic liver cancer undergoing radiation therapy or surgery

Conditions: Hepatocellular Carcinoma; Intrahepatic Cholangiocarcinoma; Stage IV Liver Cancer; Stage IVA Liver Cancer; Stage IVB Liver Cancer; Vascular Thrombosis

Summary: this pilot trial studies how well single photon emission computed tomography (spect)/computed tomography (ct) with technetium tc-99m sulfur colloid works in measuring liver function in patients with liver cancer that has or has not spread to other place in the body who are undergoing radiation therapy or surgery. diagnostic procedures, such as sulfur colloid spect/ct scans, may measure normal liver tissue before, during and after treatment and help doctors plan better treatment for liver cancer patients.

outline: patients are assigned to 1 of 2 cohorts depending on which standard of care they are receiving outside of this study, as part of their cancer treatment: rt or surgery. all patients have a total of 3 spect/ct imaging with 99mtc-sc. the first scan in both cohorts is routine medical care (not experimental) and takes place prior to initiation of rt or surgery. two follow up scans are part of the protocol. cohort a (patients receiving radiation therapy per standard cancer treatment): the first follow up scan occurs at mid-rt, and the second one at 1 month post-rt. cohort b (patients undergoing surgery per standard cancer treatment): the first follow-up scan occurs 3-5 days postoperatively, and the second one at 1 month post-operatively. an additional intravenous (iv) contrast enhanced ct scan (70 second delay) will be obtained immediately following the spect/ct scan for all 3 spect/ct scans. after completion of study, patients are followed up at 6 months.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of hepatocellular carcinoma (hcc), intrahepatic cholangiocarcinoma, or metastatic liver cancer planned to receive definitive doses of radiation or surgical resection are eligible * measurable hepatic disease and/or presence of vascular tumor thrombosis * diagnostic ct or magnetic resonance imaging (mri) scan within 2 months of study entry * there are no limits on prior therapy; patients are allowed to have prior systemic therapy, radiation therapy, radiofrequency ablation, catheter-based therapies, and surgery; patients are allowed to have concurrent chemotherapy with radiation treatment * ability to understand and the willingness to sign a written informed consent document exclusion criteria: * patients unable to tolerate a spect/ct 99mtc-sc scan * patients who are not planning to adhere to the required follow up schedule as outlined in this protocol * pregnant women * women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception * patients unable to provide informed consent
comparison of postprandial glucose control associated with biod-531 vs. humalog mix 75/25 vs. humulin r u-500

Conditions: Type 2 Diabetes Mellitus

Summary: the study is to compare meal time glucose control associated with biod-531, a rapidly absorbed concentrated insulin to that associated with humalog mix 75/25 and humulin r u-500.


Eligibility criteria:
inclusion criteria: * age 18-65 * bmi \> 25 kg/m2 * type 2 diabetes mellitus * hba1c \< 10.0% * subject uses 50-200 units of insulin/day exclusion criteria: * type 1 diabetes mellitus * history of bariatric surgery * corticosteroid therapy * significant cardiovascular or other major organ disease * females who are breast feeding or pregnant * a sexually active person not using adequate contraceptive methods
cold plasma for the reduction of lymphoceles following plnd

Conditions: Lymphoceles Following Pelvic Lymph Node Dissection

Summary: this study protocol will evaluate the efficacy of bovie medical's j-plasma® helium based plasma technology in the reduction of lymphoceles following pelvic lymph node dissection (plnd) during robotic assisted radical prostatectomy (rarp). the j-plasma® handpiece will be used during the plnd by dissecting the lymph nodes and sealing the lymphatic channels to prevent lymph leakage.

participants evaluated and scheduled for a plnd during robotic assisted radical prostatectomy who have met the study inclusion criteria and who have also given informed consent will be enrolled. enrolled participants will have their plnd performed using j-plasma® for dissection and sealing of lymphatic channels. an abdominal-pelvic ultrasound will be completed at a follow-up period ranging from 4-12 weeks post operatively to determine if a lymphocele is present. the occurrence rate of lymphoceles in this trial group will be compared to retrospective data from the principal investigator's practice and other published data to determine if the occurrence rate has been reduced.

Eligibility criteria:
inclusion criteria: 1. primary diagnosis of prostate cancer (icd-10:c61) 2. prostate specific antigen (psa) level =/\> 10ng/ml 3. gleason score =/\> 7 4. planned elective robotic assisted radical prostatectomy with planned pelvic lymph node dissection. 5. willing and able to return to clinic for standard of care abdominal ultrasound within 12 weeks post operatively. 6. able to provide informed consent exclusion criteria: must answer no to all: 1. patient is unwilling or unable to sign or understand informed consent 2. patient resides outside of the united states 3. performance of lymph node dissection was aborted.

Keywords: lymphocele pelvic lymph node dissection robotic assisted radical prostatectomy plnd rarp prostatectomy patel
aflibercept as adjunctive treatment for filtration surgery in neovascular glaucoma

Conditions: Intraocular Pressure; Neovascular Glaucoma; Vascular Endothelial Growth Factor Overexpression; Glaucoma Secondary to Eye Inflammation

Summary: purpose: to investigate intravitreal aflibercept (iva) injection as an adjunctive treatment to trabeculectomy with mitomycin c (tmc) and panretinal photocoagulation (prp) for neovascular glaucoma (nvg). setting: faculty of medicine siriraj hospital, mahidol university, bangkok, thailand study design: prospective interventional case series methods: prp and iva (2 mg/0.05 ml) injection were given, and tmc was performed within 2 weeks after iva. additional prp, laser suture lysis, subconjunctival 5-fluorouracil injection, and bleb needling were performed after tmc if indicated. best-collected visual acuity (bcva), intraocular pressure (iop), surgical complications, and number of anti-glaucoma medications were collected.


Eligibility criteria:
inclusion criteria: * consecutive patients with neovascular glaucoma who presented at the department of ophthalmology, faculty of medicine siriraj hospital, mahidol university, bangkok, thailand during november 2018 to october 2019. * aged more than 18 year-old exclusion criteria: * patients who received any anti-vascular endothelial growth factor treatment before participation
inflammatory response secondary using intravenous anesthesia versus inhalation anesthesia with halogenated agents

Conditions: Pulmonary Resection

Summary: lung ventilation required for lung resection surgery induces a proinflammatory response including cytokine production and recruitment of leukocytes and macrophages in the lung associated with postoperative complications, mainly acute lung injury (ali). the lung-protective ventilation has been shown reduce this inflammatory response and play a protective role against ali, even though it is unclear the role of intravenous and inhalational anesthetic agents in immunomodulation of the inflammatory response during lung ventilation and its possible protective role against ali. this study aims to determine the effect of anesthetic agents on markers of lung inflammation, the mechanisms of oxidative stress and ischemia-reperfusion, and assess the relationship between these mediators and postoperative morbidity defined as percentage of postoperative lung complications (ali / ards, pneumonia and atelectasis), length of stay in icu, hospital stay and mortality at 30 days. the investigators hypothesis, based on results of our group in animal research, is that inhalants cause a lower proinflammatory response to intravenous agents for lung resection surgery. a clinical trial is design with two groups (propofol, sevoflurane) managed all with lung protective ventilation, in which the markers will be measured before and after one-lung ventilation in both lungs and in plasma before, during and after one-lung ventilation. postoperative lung complications, icu and hospital stay and 30 days mortality.


Eligibility criteria:
inclusion criteria: * candidates to lung resection surgery at hospital general universitario gregorio marañón (males and females) * willing to participate and sign informed consent * age \> 18 años and legal capable * no urgent surgery. * fev1 \>50% or cvf \> 50% * no previous steroids or immunosuppressors chronic treatment (three months before the surgery) exclusion criteria: * pregnancy and breast feeding * propofol or sevoflurane hypersensibility. * have received blood derivate product within 10 days before surgery. * when protective pulmonary ventilation is not possible during one lung ventilation. * heart failure \> ii nyha within one week before surgery

Keywords: one lung ventilation inflammatory response thoracic surgery
clinical data collection in studying clinical factors associated with post-surgery chronic opioid use in patients with head and neck cancers

Conditions: Head and Neck Carcinoma

Summary: this trial studies the risk of developing disorders associated with chronic opioid use post-surgery in patients with head and neck cancers. clinical data collection may help doctors to learn how often and how likely disorders associated with the use of opioid pain medication may occur in patients with head and neck cancer who are having surgery as part of their treatment plan.

primary objectives: i. assess prevalence of chronic opioid use and severity of symptom burden (m. d. anderson symptom inventory-head and neck \[mdasi-hn\]) in patients undergoing surgery of head/neck cancer. secondary objectives: i. to investigate the extent of association of chronic opioid use with risk of opioid use disorder (as assessed by screener and opioid assessment for patients with pain\[soapp-14\] and cut down, annoyed, guilty and eye opener \[cage\] scores) and psychosocial factors (as assessed by mdasi). ii. to assess frequency of positive risk of opioid use disorder as assessed by screener and opioid assessment for patients tool (soapp-14) and cage-adapted to include drugs (aid). iii. assess frequency of aberrant opioid use behaviors. iv. assess frequency of post-operative complications. outline: patients complete questionnaires and quality of life assessments over 10-15 minutes at pre-surgery, after-surgery, at discharge, within 2-3 weeks after surgery, and within 90 days after surgery.

Eligibility criteria:
inclusion criteria: * patients with head and neck cancer scheduled for combined head and neck surgery - plastic surgery free flap * competent to give informed consent * ability to read and write in english exclusion criteria: * patient not willing to participate * not competent to give informed consent * inability to read and write in english
treatment of suicidal women with borderline personality disorder

Conditions: Borderline Personality Disorder; Suicide

Summary: this study is a component analysis of dialectical behavior therapy (dbt) to determine the importance of dbt skills training and dbt individual therapy in treating suicidal women with borderline personality disorder.

people with borderline personality disorder have limited behavioral skills and react abnormally to emotional stimulation. standard dialectical behavior therapy (sdbt) has been shown to be an effective treatment for borderline personality disorder. this treatment combines weekly group sessions, at which patients learn new ways of dealing with their emotions, with weekly individual sessions with a therapist to discuss their emotions. the study compares sdbt to both individual dbt with no skills training and dbt skills training with no individual therapy. the study will determine whether efficacy of standard dbt is reduced when either dbt skills training or individual dbt therapy is removed. participants are randomly assigned to receive 1 year of sdbt, dbt with group sessions but no individual sessions, and dbt with individual sessions with no group sessions. participants are monitored for 1 year after completing their assigned therapy. throughout the 1-year study and during the 1-year follow-up period, self-report scales and questionnaires are used to assess participants every 4 months. these scales and questionnaires measure participants' suicidal thoughts and attempts, treatment compliance, emotional coping skills, social functioning, and overall well-being.

Eligibility criteria:
inclusion criteria: * diagnosis of bpd * at least one suicide attempt in the year prior to study entry and at least one intentional self-injury within the 8 weeks prior to study entry * willing and able to comply with all study requirements exclusion criteria: * iq less than 70 * life-threatening anorexia * street homelessness with no contact information * admittance to a hospital with no expectation of discharge within 3 weeks prior to study entry or sentenced to a jail or prison term that will last for more than 3 weeks * ordered by the court to receive psychological treatment * meet dsm-iv criteria for schizophrenia, bipolar disorder, or seizure disorder * medical conditions other than bpd that may interfere with the study

Keywords: suicide women emotions psychotherapy, group
human ovarian follicular dynamics and emergency contraception

Conditions: Contraception

Summary: the researchers hypothesize that emergency contraception (ec) will initiate the changes associated with atresia or ovulatory failure at all stages of follicular development and that the image attributes associated with atresia will be similar regardless of the diameter of the dominant follicle when ovarian suppression is initiated. second, changes associated with atresia may be observed, but ovulation of the dominant follicle is unimpeded.

this study is a single-center, randomized, open-label, double-controlled protocol to study the pattern of ovarian follicular growth and regression in two groups of women. the first group will use plan b, which is a progesterone only oc containing 0.75 levonorgestrel. the second group of women will use the yuzpe regimen, which uses 50 mg ethinyl estradiol/0.5 mg levonorgestrel pills at different stages of the menstrual follicular cycle.

Eligibility criteria:
inclusion criteria: 1. female volunteers of childbearing potential; 2. are first time users of oral contraception (oc) or have discontinued oc at least 1 month prior to study entry; 3. age between 18 and 40 years old; 4. normal body mass index (18-38); 5. has signed informed consent form; and 6. is in good health as confirmed by medical history, physical examination. exclusion criteria: 1. a positive pregnancy test will automatically exclude the volunteer from participation in this study. 2. any contraindication for oral contraception use; 3. irregular menstrual cycles; 4. ultrasonographic evidence of ovarian dysfunction, such as polycystic ovary syndrome (pcos); 5. pregnancy (suspected or diagnosed) or lactation; 6. history or suspicion of drug or alcohol abuse; 7. participation in an investigational drug trial within the 30 days prior to selection; 8. exhibits a disorder that is a contraindication to steroid hormonal therapy, including, for example, the following conditions: * history of, or actual, thrombophlebitis or thromboembolic disorders. * history of, or actual, cerebrovascular disorders. * history of, or actual, myocardial infarction or coronary artery disease. * acute liver disease. * history of, or actual, benign or malignant liver tumors. * history of, or suspected, carcinoma of the breast. * known, or suspected, estrogen-dependent neoplasia. * undiagnosed abnormal vaginal bleeding. * any ocular lesion arising from ophthalmic vascular disease, such as partial or complete loss of vision or defect in visual field.

Keywords: emergency contraception follicle ovulation blood pressure fertility control inhibition of fertilization
effect of upper eyelid surgeries on corneal characteristics

Conditions: Eyelid Diseases; Ptosis, Eyelid

Summary: the goal of this prospective observational study is to learn about the impact of conventional eyelid correction surgery on the eye's health and function in ptosis and eyelid retraction patient. the main questions it aims to answer are: • 1. changes in corneal topography, higher-order corneal aberrations, corneal biomechanical characteristics, and corneal epithelial thickness before and after the surgery 2. influence of corneal refraction examinations , vision change, and tear film function after the surgery fifty participants will undergo conventional eyelid correction surgery by the same ophthalmologist (yh wei) and non-invasive examinations before and after the surgery. the patient will be separate to 2 groups, including 30 with correction for ptosis and 20 with correction for eyelid retraction. the research will collect information of the operated eye and fellow eye, and the data will be compared between operated and fellow eye and with the other group.

the position of the upper eyelid affects the health and function of the eye. ptosis can obstruct the vision, and eyelid retraction can result in the loss of proper protection of the ocular surface. through conventional upper eyelid correction surgery, the height of the upper eyelid can be adjusted to a proper position. however, after upper eyelid surgery, the pressure of the upper eyelid on the corneal surface may change, affecting corneal topography, higher-order corneal aberrations, corneal biomechanical characteristics, and corneal epithelial thickness. these changes may affect postoperative vision and visual quality. the impact of upper eyelid surgery on corneal refraction and corneal biomechanical characteristics remains inconclusive in current studies, and the impact on corneal epithelial thickness is even less investigated. this is a prospective observational study, expecting to enroll 50 patients who have undergone upper eyelid surgery, including 30 for ptosis correction and 20 for eyelid retraction correction. non-invasive examinations will be used to assess changes in corneal topography, higher-order corneal aberrations, corneal biomechanical characteristics, and corneal epithelial thickness before and after the surgery to understand the impact of upper eyelid surgery on the ocular surface and the possible mechanism or influencing factors of postoperative vision changes.

Eligibility criteria:
inclusion criteria: group 1: * marginal reflex distance 1 (mrd1) ≦ 2-2.5 mm * levator muscle function (lmf) ≧ 8 mm group 2: * with upper scleral show exclusion criteria: * pregnancy * previous corneal surgery * with corneal scar * pterygium * keratoconus * significant ocular surface disease * wearing rigid contact lens

Keywords: blepharoplasty
crossover study with the proseal and supreme laryngeal mask airway

Conditions: Paralysis

Summary: the lma supreme is a new extraglottic airway device which brings together features of the lma proseal, fastrach and unique. we test the hypothesis that ease of insertion, oropharyngeal leak pressure, fiberoptic position and ease of gastric tube placement differ between the lma proseal and the lma supreme in paralyzed anesthetized patients

the lma supreme is a new extraglottic airway device which brings together features of both the lma proseal (high seal cuff, gastric access and bite block - to facilitate ventilation, airway protection and airway obstruction, respectively), the lma fastrach (fixed cuve tube and guiding handle - to facilitate insertion and fixation) and the lma unique (single use - prevention of disease transmission). the new features are that the airway tube incorporates a drain tube within its lumen to shorten and straighten its path, it is oval-shaped to match the shape of the mouth and to reduce rotation in the pharynx, the inner cuff has been strengthened to prevent airway obstruction from infolding and epiglottic fins have been added to prevent airway obstruction from epiglottic downfolding. in the following randomized, crossover study, we test the hypothesis that ease of insertion, oropharyngeal leak pressure, fiberoptic position and ease of gastric tube placement differ between the lma proseal and the lma supreme in paralyzed, anesthetized patients

Eligibility criteria:
inclusion criteria: * american society of anesthesiology physical status grade i-ii * age 18-80 yr * elective gynecological surgery * supine position exclusion criteria: * known or predicted difficult airway * body mass index \>35 kg m-2 * risk of aspiration

Keywords: lma supreme lma proseal laryngeal mask airway ventilation
evaluation of the active sentry system during cataract surgery with the centurion phacoemulsifier

Conditions: Cataract Surgery

Summary: each new generation of phacoemulsification system has aimed to optimize the control of fluidics and the delivery of energy during phacoemulsification. nicoli cm et al., (j cataract refract surg 2016;42:157-162) suggested a better anterior chamber stability when using an active fluidics system. malik pk et al., (eye and vision 2017;4:22) showed that using an iop based phacoemulsification system in association with the use of an intrepid balanced tip provides a reduction in cde (cumulated dissipated energy and efu (estimated fluid usage). it has also been shown that a lower cde provides obvious benefits: less endothelium cells damages and lower complication rates (mady ma et al., clin.ophthalmol. 2012; 6:503-10). the latest technologies, i.e. the active sentry handpiece and hybrid tips, have been introduced to further improve the safety of phacoemulsification. the active sentry system has moved pressure sensors closer to the operated eye, hence further reducing the risk of surge during procedures. (thorne a et al. phacoemulsifier occlusion break surge volume reduction, j cataract refract surg. 2018;44:1491-1496). the hybrid tips have been designed to prevent posterior capsule rupture in the event of contact with the capsule. this new technology allows phacoemulsification procedures under reduced infusion pressures and a "high-vacuum - low energy" strategy which may lead to a safer procedure. data from this study will try to demonstrate that cataract surgeries with active sentry will need less cde and therefore may be safer, due to the surge effects decrease. this cde parameter will be analysed according to differents subgroups: presence of hybrid tip or balanced tip, cataract score based on the who nuclear grading recommendation (thylefors b et al., (2002) the who cataract grading group, ophthalmic epidemiology, 9:2, 83-95) the recent experiences conducted in real world condition in different sites have suggested that centurion with as was able to improved settings: maximum vacuum and ultrasound (us) time reduction and as a consequence a 20 to 30% cde reduction.


Eligibility criteria:
inclusion criteria: * all consecutive patients undergoing unilateral or bilateral cataract surgery with the centurion phacoemulsifier, with the ability to give informed consent. * patients will undergo the cataract surgery with or without the active sentry module and with or without hybrid tip according to centers practice. * patients will undergo a cataract scoring (nuclear grade 1 to 3) prior surgery as described in the who recommendation: exclusion criteria: * patients with : * pupil dilation \<5mm * zonular defects * corneal opacities

Keywords: cataract surgery phacoemulsification cumulated dissipated energy active sentry centurion