Kornimate/medical-research-clean huggingface dataset:
neoadjuvant chemo-immunotherapy followed by concurrent chemoradiotherapy and immunotherapy in lacc

Conditions: Locally Advanced Cervical Cancer

Summary: concurrent chemoradiotherapy -immunotherapy followed by ici maintenance was proved to improve the pfs by the keynote-a18 in the lacc patients, and still more than 30% progressed. neoadjuvant chemo-immunotherapy in lacc resulted in higher pcr rate. this prospective single arm study is to investigate the efficacy and safety of neoadjuvant immuno-chemotherapy followed by concurrent chemoradiotherapy and consolidative immunotherapy in lacc patients.

this prospective single arm study aims to investigate the efficacy and safety of neoadjuvant immuno-chemotherapy followed by concurrent chemoradiotherapy and consolidative immunotherapy in lacc patients. patients will be given two cycles of tp regimen + sintilimab, followed by concurrent chemoraiotherapy, and consolidative 6 cycles of sintilimab.

Eligibility criteria:
inclusion criteria: * (1)age between 18 and 75; (2)untreated patients with pathologically proven squamous carcinoma; (3)t3-4n1-2m0 cervical cancer; (4)eastern cooperative oncology group (ecog) performance status of 0-1; (5)adequate hematological, renal and hepatic functions: (6)hemoglobin \> 8.0 g/dl ; neutrophils \> 2000 cells/μl; leukocytes \> 4 × 109/l; platelets \> 100 × 109/l; serum urea nitrogen (bun) ≤ 1.5 × upper normal limit (unl); serum creatinine (cr) ≤ 1.5 × upper normal limit (unl); serum alt/ast ≤ 2.5× unl; serum total bilirubin ≤ 1.5× unl; (7)life expectancy \> 6 months; (8)eligible for concurrent chemoradiotherapy assessed by principle investigator; (9)no obvious active bleeding; (10)written informed consent must be available before study registration. exclusion criteria: * (1)recurrent or distant metastatic disease; (2)prior malignancies (other than curable non-melanoma skin cancer) within 5 years; (3)active autoimmune diseases requiring systemic treatment or other diseases requiring long-term use of substantial amount of hormones or other immunosuppressants; (4)patients who need to receive systemic corticosteroids (dose equivalent to or higher than prednisone 10mg qd) or other immunosuppressants within 14 days before enrollment or during the study; (5)vaccination of live attenuated vaccine 30 days before enrollment, or planned vaccination of live attenuated vaccine during the study; (6)previous organ transplantation or hiv patients; (7)allergic to macromolecular proteins /monoclonal antibodies, or to any test drug component; (8)active acute or chronic viral hepatitis b or c. hepatitis b virus (hbv) dna\> 2000 iu/ml or 104 copies/ml; hepatitis c virus (hcv) rna\> 10\^3 copies/ml.

Keywords: immunotherapy lacc chemoradiotherapy
bedside ultrasound assessment of feeding tube position in the intensive care unit

Conditions: Critical Illness; Tube Feeding

Summary: this diagnostic accuracy study aims to evaluate the performance of bedside ultrasound compared to x-ray in detecting the correct position of feeding tubes among critically ill adult patients. the main questions it aims to answer are: • diagnostic accuracy of bedside ultrasound • feasibility of its wide adoption among practitioners with minimal training in busy intensive care units.

this multicenter diagnostic accuracy study consists of a non-consecutive convenience sample of adult patients admitted to the intensive care unit starting from march 2023 who require a feeding tube as defined by the medical attending team. right after feeding tube placement following the institutional standard operating procedure, attending physicians perform bedside ultrasound assessment to verify the correct position of the tube. they report whether or not visualizing the feeding tube in four steps: 1) in the esophagus from either the right or left side of the patient's neck; 2) in the transverse view of the patient's epigastrium; 3) in the longitudinal view of the patient's epigastrium and 4) during the injection of 20 ml of air into the tube to detect the 'fogging sign.' finally, the abdominal radiograph (gold standard) confirms the gastric or duodenal placement of the feeding tube.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years old; * need for a tube feeding for receiving diet and/or medication, as indicated by the medical team; * blind insertion of a tube feeding in the intensive care unit, following the standard operating procedure; * presence of a trained physician for ultrasound scanning of the tube feeding immediately after installation. exclusion criteria: * major abdominal postoperative wounds, peritoneostomy, or any other conditions that preclude ultrasound abdominal examination; * exclusive presence of a gastric decompression probe, which does not require radiographic confirmation; * tube feeding introduced under digestive endoscopy guidance; * gestation; * abdominal radiography confirming the tube position obtained before the ultrasound assessment.
link between the sensitivity of kisspeptin signalling and pubertal onset in boys.

Conditions: Reproductive Physiological Phenomena

Summary: the specific objective of this study was to investigate the sensitivity of kisspeptin receptor 1 (kiss1r) by determining the responsiveness of gnrh neuron to kisspeptin administration across the pubertal stages and adult group through measuring plasma lh (luteinizing hormone) and testosterone concentrations.

no studies in humans are available regarding kiss1r signalling that, whether expression of the kiss1 or kiss1r sensitivity increases during the pubertal transition in boys. kisspeptin regulates hpg (hypothalamic pituitary gonadal) axis by secreting gnrh that acts on the pituitary gonadotrophs to secrete lh and fsh. but in contrast to pubertal period, juvenile period kisspeptin pulsatility is reduced, that leads to low gnrh pulsatility and low level of plasma lh, fsh and testosterone. the objective of this study was to determine the response of exogenous kisspeptin in various juvenile stages up to puberty and also in the adults by measuring the level of plasma lh and testosterone. this study would help us to determine that whether there is any link between the increased sensitivity of kisspeptin signalling and puberty onset?, or at what tanner stage pre pubertal boys enter into puberty.

Eligibility criteria:
inclusion criteria: * boys were classified into 5 different tanner stages (i-v) according to the criteria of feingold d. in atlas of physical diagnosis. pediatric endocrinology. 2nd ed. philadelphia. wb saunders; 1992, pp. 16-19. for comparison, adult men were also recruited. exclusion criteria: * individuals with chronic illness or disorder, i.e. hepatic and renal complications, epilepsy, pneumonia, asthma, orchitis, hernia, cryptorchidism, mental retardation, etc. were excluded from this study

Keywords: puberty, sexuality
haploidentical transplantation with cd3/cd19 depleted grafts in patients with hematologic malignancies

Conditions: Hematologic Malignancies

Summary: the purpose of this study is to study the feasibility and toxicity of allogeneic haploidentical hematopoietic cell transplantation with cd3/cd19 depleted stem cells and a dose reduced conditioning.

transplantation of a cd3/cd19 depleted stem cell grafts after dose reduced conditioning for the treatment of treatment refractory or relapsed hematologic malignancies after preceding allogeneic or autologous hematopoietic cell transplantation.

Eligibility criteria:
inclusion criteria: * age \ 18 years * karnofsky \>60% * high risk hematologic malignancy or relapse after preceding auto/allo hct in patients with: * all * aml * pnh * mds (raeb-t/secondary aml) * nhl * all * hd * cml * mm * no hla-identical mrd or urd if not preceding allo-hct * use haploidentical donor with kir-mismatch if choice exclusion criteria: * \< 3 months after preceding hct * active cerebral seizures * \> 30% blasts in bm if all/aml/cml-bc * completely chemo-refractory * preceding myocardial infarction * ejection fraction \<30 % echocardiography * creatinine clearance \<50 ml/min * respiratory insufficiency on supplemental o2 or dlco \< 30% * allergy against murine antibodies * hiv infection * pregnancy * unable for informed consent

Keywords: haploidentical transplantation immunomagnetic cell sorting allogeneic hematopoietic cell transplantation dose reduced conditioning
percutaneous treatment of carpal tunnel syndrome with scan

Conditions: Carpal Tunnel Syndrome

Summary: the objective of the study is to evaluate in patients suffering from carpal tunnel syndrome resistant to medical treatment, clinical course after percutaneous treatment under ultrasound guidance. 40 patients will be included in the study. the following parameters will be evaluated: patient satisfaction, pain, functional disability, quality of life and time to return to work. the medico-economic aspect will be analyzed.

ultrasound analysis of carpal tunnel is used for many years, especially for diagnostic purposes. investigators have shown, first by a study of 104 cadavers that it was possible to reduce the opening by making the gesture under ultrasound guidance and to perform the procedure under local anesthesia. then investigators performed an open study of 25 patients confirming the absence of iatrogenic lesions with this new technique. the percutaneous treatment of carpal tunnel syndrome under ultrasound guidance is a gesture of interventional radiology. one can envisage making this type of treatment in interventional radiology room which overcomes the operating room and thus reduce costs. the objective of the study is to continue the study of percutaneous treatment of carpal tunnel syndrome under ultrasound guidance by an open study conducted in interventional radiology room.

Eligibility criteria:
inclusion criteria: * patient older than 18 years who signed the informed consent. * patient with an carpal tunnel syndrome exclusion criteria: * patient has already undergone surgery of carpal tunnel syndrome * patient with contra-indications to anesthesia (heart failure, kidney, liver). * pregnant women * alcoholics in weaning period * patient whose consent is altered or unable to get a safety procedure * patient with contra-indication to lidocaine * patient with contra-indication for the realization of ultrasound endoscopy (carpal tunnel syndrome secondary or anastomosis between the median and ulnar nerves: anastomosis berritini)
ben-2001 in parkinson disease patients with excessive daytime sleepiness

Conditions: Excessive Daytime Sleepiness; Parkinson Disease

Summary: this phase 2b study is designed as multicentre, multinational, randomized, double blind, parallel group and placebo controlled with three doses of bavisant (0.5, 1, and 3 mg/d) in subjects with excessive daytime sleepiness with parkinson's disease.

phase 2b study will be conducted with the aim of investigating the efficacy and safety of three fixed doses of bavisant (0.5, 1 and 3 mg/d) compared to placebo for the treatment of excessive daytime sleepiness (eds) in subjects with parkinson's disease.

Eligibility criteria:
inclusion criteria: * subjects of either sex aged 50 to 80 years \*subjects with previous diagnosis of parkinson's disease (following the uk parkinson's disease society brain bank clinical diagnostic criteria)\* * subjects capable of understanding and complying with protocol requirements * subjects with medical history of excessive daytime sleepiness exclusion criteria: * subjects with excessive daytime sleepiness due to conditions other than parkinson's disease (including narcolepsy) * subjects with clinical evidence of depression with significant psychiatric comorbidities (hamilton rating scale for depression - ham-d score greater than or equal to 17; with or without treatment) * subjects with evidence of significant fatigue (fatigue severity scale - fss greater than or equal to 36 * subjects with known history of abuse of alcohol or other addictive substances in the 6 months prior to inclusion. * subjects with known allergies or hypersensitivity to bavisant or any of its excipients. * subjects who are pregnant or lactating.
laser acupuncture therapy in postpartum low back pain

Conditions: Lower Back Pain; Postpartum Period

Summary: over half of women after giving birth have low back pain (lbp), however, lbp is often accepted as a normal part of postpartum. unsolved low back pain undoubtedly affects women's physical health and may be negatively affect their psychological health. this study was aimed to investigate the efficacy of laser acupuncture therapy (lat) in postpartum lbp. postpartum women with lbp admitted at a postpartum care center were recruited and randomly assigned to the intervention group or the control group. the participants in the intervention group underwent 10 sessions/2 weeks of lat and received standard obstetric care. the participants in the control group only received standard obstetric care. primary outcome measurements were visual analogue scale (vas) for pain and salivary cortisol values. secondary outcome measurements were chinese versions of the roland and morris disability questionnaire (rmdq), oswestry disability index (odi) version 2.1and the perceived stress scale (pss).


Eligibility criteria:
inclusion criteria: 1. age not less than 20 years 2. women postpartum within one month 3. low back pain with visual analogue scale (vas) score ≧1 4. low back pain was not relieved by rest for 30 minutes. exclusion criteria: 1. with systemic diseases 2. with cancers 3. with psychiatric diseases 4. under treatment for severe pain by a physician.

Keywords: laser acupuncture therapy low back pain postpartum low-level laser therapy
impact of metformin on in vitro fertilization outcomes in overweight and obese pcos women

Conditions: Polycystic Ovary Syndrome

Summary: rct to investigate whether metformin co-treatment would improve ivf outcomes in overweight and obese women with pcos.


Eligibility criteria:
inclusion criteria: * the inclusion criteria restricted the patients to 39 years old with basal fsh \< 10 iu/ml and normal tsh and prolacin. exclusion criteria: * exclusion criteria were diabetes mellitus (excluded by gtt), renal or liver disease, associated male factor, documented tubal factor or pelvic adhesions, elevated 17 alfa hydroxyprogesterone level and fsh ≥10 iu/ml. we also excluded the women who started program or medications to reduce their weight and those who their partner has abnormal semen parameters according to the world health organization parameters (who, 2010)
feedback and psychotherapeutic competencies

Conditions: Mental Disorders

Summary: the purpose of the current study is to examine the influence of feedback on psychotherapeutic competency. the present randomized controlled study compares a feedback condition with a non-feedback condition. therapists in the feedback condition receive feedback after every fourth session. the feedback is given by two trained and independent raters. the raters are licenced and experienced psychotherapists. therapists in the non-feedback condition receive no feedback during the psychotherapy.


Eligibility criteria:
therapists inclusion criteria: * having successfully completed the interim audit * having started to treat ambulant patients * remaining at least 6 month in the ambulance exclusion criteria: - patients inclusion criteria: * meeting icd 10 criteria for a mental disorder * informed consent exclusion criteria: * currently in psychotherapy * suicidal tendency * clinical diagnosis of alcohol or drug addiction, acute schizophrenia, schizoaffective disorder or bipolar disorder * clinical diagnosis of personality disorder cluster a (odd disorders) and b (dramatic, emotional or erratic)

Keywords: feedback therapeutic competencies training
single incision laparoscopic surgery (sils) versus conventional laparoscopic hysterectomy

Conditions: Uterine Myoma; Uterine Adenomyosis

Summary: multi-center prospective randomized trial of single port laparoscopic surgery (sils) versus conventional 3-4 ports laparoscopic hysterectomy. hypothesis is that conversion rate of sils is not inferior to that of conventional approach.


Eligibility criteria:
inclusion criteria: * symptomatic (dysmenorrhea, palpable mass, pelvic pain or discomfort urinary symptom, increasing size, menorrhagia) myomas or adenomyomas * uterine size \< gestational age of 14 weeks * informed consent exclusion criteria: * medical diseases such as heart failure, renal insufficiency, liver cirrhosis, pancreatitis, uncontrolled dm * huge uterine size \> gestational age of 14 weeks

Keywords: sils laparoscopic hysterectomy cosmetic outcome pain
coordination and locomotor problems in patients with covid-19 virus

Conditions: Covid19; Motility Disorder; Balance

Summary: coordination and locomotor problems in patients with covid-19 virus


Eligibility criteria:
inclusion criteria: * covid 19 diagnosis exclusion criteria: * severe heart problems * severe demeanor * alcoholism * drug problems

Keywords: 6mwt berg balance beam walking
modafinil effects on eeg biomarkers of reward and motivation

Conditions: Healthy Adults

Summary: the effects of modafinil on measures of brain electrical activity will be tested.


Eligibility criteria:
exclusion criteria * history of substance abuse * mental illness in a first degree relative * significant medical illness (e.g. cancer, diabetes, heart disease, hiv) * history of seizure * open head injury or closed head injury with loss of consciousness \> 1 min * pregnancy * current psychotropic drug use * r-hand injury * hearing or visual impairment * urine toxicology positive for recreational drug use
a randomized trial of changing exercise and physical activity behavior in asthma patients

Conditions: Asthma

Summary: the primary objective of this randomized trial is to evaluate a novel intervention of induced positive affect and induced self-affirmation to increase physical activity in patients with asthma.

the primary objective of this randomized trial is to evaluate a novel intervention of induced positive affect and induced self-affirmation to increase physical activity in patients with asthma. at the start of the trial all patients in conjunction with their physicians will select a program of mild to moderate physical activity or exercise to be adopted and maintained on a routine basis. all patients will record perceived exertion and pedometer measurements in a log diary. all patients will be contacted by telephone at set time intervals to encourage them to continue their selected physical activity or exercise. patients randomized to the intervention arm will also receive induced positive affect and self-affirmation throughout the study period. patients in the control arm will not receive the positive affect and self-affirmation components.

Eligibility criteria:
inclusion criteria: patients will be eligible for this study * if their physicians consider them medically able to participate, if they are 18 years of age or older * if they have a diagnosis of mild to moderate asthma based on the nhlbi asthma expert panel's classification system which rates symptoms, frequency of exacerbations, nocturnal attacks, activity restriction, use of medications, and pulmonary function. exclusion criteria: patients will be excluded from this study for the following reasons: * if they are unable to walk several blocks for whatever reason; * if they have musculoskeletal or neurological deficits that preclude increased physical activity; * if they have other pulmonary diseases; * if they have cardiac disease or other severe comorbidity; * if they are unable to provide informed consent because of cognitive deficits; * if they refuse to participate.

Keywords: asthma behavior change physical activity risk reduction
neurocircuitry of obsessive-compulsive disorder: modulation by transcranial magnetic stimulation

Conditions: Obsessive-Compulsive Disorder

Summary: the purpose of this study is to test the effects of non-invasive neuromodulation, transcranial magnetic stimulation on brain function in individuals with obsessive-compulsive disorder (ocd). this study is focused on the mechanism(s) by which brain stimulation might change the functioning of regions implicated in ocd, and thereby inform possible future therapeutic uses.


Eligibility criteria:
inclusion criteria: * current primary ocd diagnosis and current y-bocs total score of ≥16 * 18-70 years of age * ability to speak, read, write, and understand english sufficiently well to complete study procedures and provide informed consent * no use of psychiatric medications or stable psychiatric medication use for a minimum of 6 week prior to study entry * ongoing psychotherapy allowed if already established for three months or more before study entry exclusion criteria: * history of primary psychotic disorder or bipolar disorder * present acute suicidality * history of head injury, epilepsy, or other clinically significant neurological illness except tic disorders * active systemic medical (metabolic, endocrine, chronic inflammatory, vascular, autoimmune) disease * premorbid intelligence quotient (iq) estimate \< 80 * visual disturbance (\<20/40 snellen visual acuity, corrected) * current, or alcohol or illicit substance abuse/dependence in the last 3 months * contraindications to tms or mri: metallic foreign objects, e.g., aneurysm clips/pacemakers, or questionable history of metal fragments, claustrophobia * women who are pregnant or breastfeeding. all women participants of reproductive age are required to have a negative pregnancy test prior to enrollment and use medically acceptable birth control throughout the study (barrier and/or oral contraceptives) * current psychotic symptoms * an increased risk of seizure, determined by history * medications judged to notably affect cortical excitability e.g., anticonvulsants or high-dose benzodiazepines (\> 4 mg/day of clonazepam or equivalent) * predominant hoarding symptoms