Kornimate/medical-research-clean huggingface dataset:
translation and validation of the performance oriented mobility assessment (poma) scale into urdu version

Conditions: Fall

Summary: the aim of this study is to translate the original english version poma scale into urdu and also determine cultural adaptation to establish its validity and reliability. this study also aims to correlate performance oriented mobility assessment (poma) scales with time up and go test in elderly population.

among older persons, age-related impairments cause loss of postural control and balance that result in pain, independency and disability. one of the most common geriatric syndromes and most serious health issue threatening the independency of older persons is fall. the impact of these fall-related injuries on older person, families and societies and its fruitful intervention has made this issue important worldwide. approximately 28-35% of people aged 65 years and 32-42% of aged 70 years' experience falls annually and 10% suffer serious injury such as, fracture, severe head trauma and joint dislocation. the incidence rate of fall is higher in hospitalized and residents of nursing home. it rises from middle age and peaks in person above 80 years. the risk factors associated with falls are, lower extremity muscle weakness, gait or balance deficits, use of an assistive device, cognitive impairment, visual deficit, arthritis and impaired activities of daily living . different scales and tests are used for risk factors for falls, balance and mobility such as berg balance scale, time up and go test and dynamic gait index and fullerton advanced balance scale. one of these scales performance-oriented mobility assessment (poma) scale. poma scale has acceptable reliability and validity as compared to frt and tug in elderly. the advantages of this scale are; applicability, low cost, easy to administer, no equipment is needed other than a standard chair and stopwatch, evaluates functional activities and assesses both balance (poma-b) and gait components (poma-g)originally poma scale was used to assess risk of fall in institutionalized populations but later on used as an assessment tool for mobility and determine effects of interventions. the poma has found to be widely used in patients who have dynamic and reactive balance deficits. it comprises 16 items (9 balance and 7 gait related). total time taken for administration is approximately 10 minutes and total score is 28; 16 is balance and 12 is gait score. some items are scored dichotomously (can/cannot perform) and others are scored 0, 1 or 2 points for quality of performance. the higher scores show low fall risk and better balance while lower score predicts poorer balance and greater risk of fall. the score 19-24/28 indicates moderate risk for falling while score \<19 indicates a "high" risk for falling.

Eligibility criteria:
inclusion criteria: * the sample will be assessed a cognition evaluation through the mini-mental test * any present or previous history of vertigo since last 6 months exclusion criteria: * patients with any neurological disorder, * previous orthopedic surgery within last 6 months, * bedridden, * wearing any prosthesis, and illiteracy.
the kinematx midcarpal total wrist arthroplasty registry

Conditions: Scapholunate Advanced Collapse (SLAC); Scapholunate Crystalline Advanced Collapse (SCAC); Scaphoid, Trapezium, and Trapezoid Advanced Collapse (STTAC); Carpal Tunnel Syndrome (CTS); Kienbock's Disease of Adults; Radial Malunion; Ulnar Translocation; Post Traumatic Arthritis; Inflammatory Arthritis; Osteoarthritis; Scaphoid Non-union Advanced Collapse (SNAC)

Summary: the goal of this observational study is to learn about functional and patient reported outcomes in patient undergoing total wrist replacement with the kinematx total wrist replacement study. the main questions it aims to answer are: * what is the range of motion (flexion, extension, radial, ulnar, grip and pinch strength) at 3-, 6-, and 12-months after surgery and yearly up to 10 years among patients having total wrist replacement with the kinematx implant. * what are the patient reported outcomes (promis, prwe, hss wrist expectations) at 3-, 6-, and 12-months after surgery and yearly up to 10 years among patients having total wrist replacement with the kinematx implant. * how do range of motion and patient reported outcomes change over the 10 years after total wrist replacement surgery? participants will be followed according to standard of care and preoperative and post-operative information for up to 10 years after surgery will be collected and entered into an electronic data base. patients are eligible to enroll into the registry before or after they have had their wrist replacement surgery.


Eligibility criteria:
inclusion criteria: * one of the following diagnoses and planned (or previously completed) total wrist arthroplasty with the kinematx total wrist: * osteoarthritis or post-traumatic arthritis * scapholunate advanced collapse (slac/snac wrist), * inflammatory arthritis (rheumatoid, psoriatic, other), * crystalline advanced collapse (scac), * stt advanced collapse (sttac), * ulnar translocation, * kienbӧck disease, * radial malunion exclusion criteria: * \<18 years of age * \>85 years of age * prisoners * children * pregnant women * contraindications to receiving the kinematx: * local, distant or systematic acute or chronic soft tissue or bony infection * physiologically or psychologically compromised patient * active wrist synovitis or severe carpal bone erosion * suspected or documented metal allergy or intolerance * insufficient extensor tendons * inadequate skin, bone, neural or vascular status * severe carpal bone malalignment, displacement, absorption, neoplastic, or carpal bone pathology * sepsis * osteomyelitis * uncontrolled/untreated osteoporosis or metabolic bone disease * metabolic or endocrinologic bone disorders * osteomalacia * distant foci of infections which may spread to the implant site * rapid joint destruction, marked bone loss or bone resorption apparent on roentgenogram

Keywords: total wrist replacement total wrist arthroplasty
pocus vs ct in diagnosis of acute dyspnea in chronic hemodialysis patients

Conditions: Dyspnea; Chronic Renal Failure

Summary: estimate the predictive value of pocus in diagnosis of different causes of acute dyspnea in hemodialysis patients and compare between pocus and ct in differentiation the causes of acute dyspnea in those population.

dyspnea is "a subjective experience of breathing discomfort that consists of qualitatively dis-tinct sensations that vary in intensity.dyspnea is a common symptom both in general practice and in hospital emergency rooms. it has been reported that 7.4% of patients presenting to emergency rooms complain of dyspnea;among patients in general practice, 10% complain of dyspnea when walking on flat ground and 25% complain of dyspnea on more intense exertion, e.g., climbing stairs.dyspnea is considered acute when it develops over hours to days.acute breathlessness in haemodialysis patients can be caused by various conditions such as acute coronary syndrome, catheter-related infection, pneumonia and pericardial effusion, as well as a reaction to the dialyser or medication given during dialysis hence, clinical acumen remains integral in evaluation of acute breathlessness in this group of patients. point of care ultrasound is complementary to a medical examination performed by primary care physicians in conjunction to physical examination to investigate unclear findings. as such it is used to find and identify either the presence or absence of specific pathological results seen in your patients.

Eligibility criteria:
inclusion criteria: * all patients maintained on regular hemodialysis equal to / more than 6 months admitted to emergency department and icu of internal medicine department from september 2021 to august 2022 presented by acute dyspnea. exclusion criteria: * • age less than 18 * diagnosed chronic pulmonary disease. * severe heart failure (nyha class iv). * active malignancy. * pregnancy. * hepatic failure (child b,c). * comatosed patients.
breakfast training based on pender's health promotion model (hpm)

Conditions: Health Education

Summary: nutrition of school-age children is very important. children at this age need to eat three main meals and at least one snack every day. breakfast, among the main meals, is an important component of a healthy diet and is vital for healthy and normal development, especially in children and adolescents. t.r. according to tüber prepared by the ministry of health, the most frequently skipped meal among school-age children is breakfast. it is necessary to raise awareness in parents and children about regular breakfast consumption and frequency and to instill healthy lifestyle behaviors. it is aimed to regulate breakfast consumption and frequency in parents and children with a web-based training based on pender health promotion model (hgm).

before starting the study, students and parents will be informed in writing and verbally. then, a pre-test will be applied with the specified data collection tools to students and parents who agree to participate in the research. then, a 6-week web-based training on breakfast consumption based on pender's health promotion model will be given. after the training, a post-test will be applied with data collection tools. then the pre-test and post-test data will be analyzed.

Eligibility criteria:
inclusion criteria: * • being a 7th grade student of secondary school, * not having a chronic disease * students who voluntarily agreed to participate in the research and received consent from their parents. exclusion criteria: * • not being a 7th grade student of secondary school, * having a chronic disease * students who do not agree to participate in the research voluntarily and whose parents\&#39; consent cannot be obtained

Keywords: breakfast consumption school age children health promotion model
cohort study of pioglitazone and bladder cancer in patients with type ii diabetes

Conditions: Diabetes; Bladder Cancer

Summary: to assess the potential association between pioglitazone and bladder cancer compared with non-pioglitazone users among patients with type 2 diabetes mellitus.

following guidance from the united states food and drug administration (fda) and european medicines agency, the university of pennsylvania and kaiser permanente northern california (kpnc) designed and conducted this study using the kpnc database to assess the potential association between pioglitazone and bladder cancer among patients with type 2 diabetes mellitus. the study was conducted over the course of 10 years, with a series of interim analyses undertaken during this period and provided to the sponsor (takeda) and the appropriate regulatory agencies. in 2011, the planned 5-year interim analysis of this study was published in diabetes care. that report included data from 1 january 1997 to 30 april 2008. following reporting of these data, there was a request from the fda for an additional fourth interim analysis at 8 years including data from 1 january 1997 to 31 december 2010. in august 2011 the fda requested inclusion of a sensitivity analysis to assess change of cohort entry criteria to minimize left censoring of exposure. included in the fda request was a duration analysis for other antidiabetic medications. in august 2014, the final 10-year analyses were completed and submitted to the sponsor and regulatory agencies. interim results previously posted on clinicaltrials.gov are available in the public archive

Eligibility criteria:
inclusion criteria: * the study cohort included both patients with an established diagnosis of diabetes mellitus prior to january 1, 1997 and those who were newly diagnosed prior to december 31, 2002. patients were eligible for the study cohort if they met any of the following criteria: 1. as of january 1, 1997 they had been diagnosed with diabetes mellitus, were age 40 or older and were members of kpnc, 2. they had been diagnosed with diabetes mellitus, reached age 40 between january 1, 1997 and december 31, 2002 and were kpnc members on their 40th birthday, or 3. had diabetes mellitus and were age 40 or older when they joined kpnc between january 1, 1997 and december 31, 2002. exclusion criteria: * diagnosis of bladder cancer recorded in the kpnc cancer registry prior to entry to the cohort or within 6 months of entry into kpnc.

Keywords: drug therapy
symbicort turbuhaler 30/60 specific clinical experience investigation

Conditions: Bronchial Asthma

Summary: the purpose of this study is to confirm the safety profile for long term treatment and maximize doses and the control status on bronchial asthma in daily clinical usage


Eligibility criteria:
inclusion criteria: * patients treated with symbicort for the first time possibly at the higher dose due to bronchial asthma exclusion criteria: -

Keywords: bronchial asthma symbicort long term use,
randomized controlled trial of the impact of mobile phone delivered reminders and travel subsidies to improve childhood immunization coverage rates and timeliness in western kenya

Conditions: Diphtheria; Tetanus; Pertussis; Hepatitis B; Haemophilus Influenzae Type b; Measles

Summary: the project goal is to conduct a randomized controlled trial (rct) to test whether mobile phone short message system (sms) reminders, either with or without mobile-phone based travel subsidies will improve timeliness, coverage, and drop-out rates of routine epi vaccines in rural western kenya.


Eligibility criteria:
inclusion criteria: 1. mother of infant aged 0-4 weeks during the study period 2. current resident of one of the study villages 3. willing to sign informed consent for the study exclusion criteria: 1. plans to move out of the study area in the next 6 months 2. resides in a village with active immunization intervention/program 3. has already received immunizations other than birth dose of bcg or polio

Keywords: short message system sms reminder mobile phone cell phone vaccination immunization mhealth
steroids after laser trabeculoplasty for glaucoma

Conditions: Glaucoma

Summary: the purpose of this study is to determine whether the choice of post-operative eye drop administered after selective laser trabeculoplasty (slt) for glaucoma affects the efficacy in lowering intraocular pressure (iop).

slt is used to lower intraocular pressure in glaucoma, but it is not know whether the choice of eyedrops administered in the post-operative period affects slt efficacy. practitioners commonly use steroid drops, non-steroidal anti-inflammatory drops, or no drops at all. this is a randomized, single-center, prospective, masked clinical trial to determine whether the choice of eyedrop affects efficacy of slt in glaucoma patients.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of glaucoma * clinician has determined that slt laser is indicated * iop currently \>18 and was ever \>21 in the past (e.g. prior to treatment) exclusion criteria: * prior history of uveitis * prior glaucoma surgery including glaucoma laser surgery * pregnant or 3 months post-partum

Keywords: glaucoma trabeculoplasty selective laser trabeculoplasty intraocular pressure
sepsis as a cause of death among elderly cancer patients

Conditions: Sepsis; Cancer

Summary: the goal of this retrospective study is to explore the association between sepsis and morality among the elderly cancer patients. data were extracted from the surveillance, epidemiology and end results( seer) database using seer\*stat software. the study included patients aged 65 years or more who were diagnosed with cancer from 2000 to 2021. the extracted data included age, race, marital status, sex, stage, surgery, chemotherapy and radiotherapy. multiple primary session was used to calculate the standardized mortality ratio (smr) as observed/expected with excess risk/10,000 and significance was achieved at 0.05.


Eligibility criteria:
inclusion criteria: * cancer patients * age 65 year or more * latency exclusion period of 0 months. exclusion criteria: - death certificate only and autopsy only cases

Keywords: sepsis cancer mortality smr seer
serum concentration of endogenous estrogens and sirtuin-1 after administration of atorvastatin and quercetin:

Conditions: Coronary Artery Disease; Menopause

Summary: chronic coronary syndrome (ccs) is the leading cause of death in women in the most developed regions of brazil. the primary etiopathogenic mechanism is the process of atherosclerosis. a healthy diet rich in fruits and vegetables is associated with a lower incidence of ccs. the higher consumption of these foods promotes greater availability of phenolic compounds, and the higher intake of these compounds is one of the main hypotheses for vascular health. quercetin, a phenolic compound, is the most abundant natural antioxidant belonging to the group of flavonoids. quercetin improves lipoprotein metabolism, has an antioxidant capacity, produces vasodilating substances in the vascular endothelium, and reduces platelet aggregability. likewise, statins are medications known to reduce cardiovascular events in women with ccs by reducing serum ldl-cholesterol levels and, to a lesser extent, by possible pleiotropic effects. in turn, sirt1 is one of the 7 classes of proteins. it mediates various metabolic pathways in response to nutritional stimuli, particularly for caloric restriction and phenolic compounds, as well as coordinating the production and secretion of important hormones. however, the impact of quercetin supplementation and statin administration on serum endogenous estrogen levels is unknown

the main objective of this study is to investigate the influence of atorvastatin and of quercetin in the serum concentrations of estradiol and estrone after the administration of atorvastatin and supplementation with quercetin. this is a randomized, double-blind, placebo-controlled, 60-day study in 60 postmenopausal women with cad, divided into three groups of 20 women each: group 1 - quercetin (500 mg/day); group 2 - atorvastatin (80 mg/day); group 3 - control (placebo).

Eligibility criteria:
inclusion criteria: * postmenopausal women; * diagnosed coronary artery disease; * stable coronary disease; exclusion criteria: * hypo or hyperthyroidism, * rheumatic disease, * use of alcohol, * hepatic failure, * renal failure * hormone replacement therapy * use of insulin

Keywords: coronary disease atherosclerosis estradiol estrone sirt1 quercetin atorvastatin polyphenols
diastolic hyperemia free index for assessment of moderate coronary stenoses

Conditions: Coronary Artery Disease

Summary: a total of 106 subjects will be enrolled at up to 3 sites. initial enrollment will occur at washington university only. after 15 subjects have been enrolled at the primary site and no serious adverse events or protocol events have occurred the additional sites will be trained and added to enrollment.

with the release of define-flair and ifr swedeheart, coronary physiology and namely ifr, have robust clinical data supporting its routine use in the cardiac catheterization lab. unfortunately, ifr is a proprietary algorithm owned by phillips volcano corporation (san diego, california, usa) limiting the use of ifr to those centers with volcano hardware. whole cardiac cycle pd/pa has been another resting measure that has been evaluated and generally performs poorly compared to ffr. although ifr is measured during the wave free period in diastole, to date there has been no assessment of diastolic pd/pa measurements and its potential correlation with the severity of coronary stenoses. most importantly, evaluating the pressure differential across the entirety of diastole must by definition contain the "ifr value" and therefore should correlate very close with the ifr assessment. preliminary unpublished data analyzing physiologic data in benchtop modeling from the verify and contrast studies suggest a very high correlation between ifr and diastolic pd/pa. this relationship strengthens when measurements are limited to 65% of diastole, hereby named the diastolic hyperemia-free ratio (dfr). these data strongly suggest that dfr could be used as surrogate for ifr when ifr is not available and thus leverage the large clinical outcomes data for ifr in a new measure that is widely available to all standard coronary pressure wires. although this preliminary data is strong, none of these measures where made prospectively in actual patients and the ifr was measured off simulated benchtop pressure waveform modeling. this study aims to perform a real-time correlation and agreement between ifr and dfr in patients with moderate coronary stenoses and indications for physiologic assessment.

Eligibility criteria:
inclusion criteria: * moderate coronary lesion deemed to need ifr assessment - angiographic severity of 40-70% that operator feels needs physiologic assessment * age 18-90 year old * single worst lesion per patient- patients may have more than one lesion assessed but only 1 lesion will be evaluated per patient in this study exclusion criteria: * stemi- angiographic severity of 40-70% that operator feels needs physiologic assessment in setting of stemi or 48hours within stemi * atrial fibrillation * inability to provide informed consent- no surrogate or healthcare proxy will be allowed to consent for this study * severe tortuosity- vessel tortuosity that the operator feels would be difficult to pass 2 pressure wires down or where pseudo lesions may be formed. * saphenous vein graft lesion

Keywords: physiologic assessment
plantar pressure values in patients with ankylosing spondylitis

Conditions: Device is Used for Evalution (Event)

Summary: this study was discovered that clinical and radiological characteristics were related to plantar pressure assessments in patients with as.

determine the correlation between the plantar pressure readings of as patients and the clinical and radiological measures utilized in the monitoring of the condition. method: this study covered 75 participants. the quality of life was measured using asqol, basmi, basfi, and basdai, and demographic information was also recorded. the pedobarographic evaluations included the recording of static and dynamic plantar pressures

Eligibility criteria:
inclusion criteria: patients diagnosed with as - exclusion criteria: patients with cognitive dysfunction, vision loss that would prevent walking on the pedobarography platform, history of surgery and neurological deficit in the lower extremity, and patients who could not walk independently -
quality of friendships in children with neurofibromatosis

Conditions: Neurofibromatosis

Summary: the aim of this study is to determine if children with a higher disease severity have lower quality friendships than children who are less severely affected and children who are unaffected. researchers will test the hypothesis that the quality of friendships is inversely related to their disease severity. specific aims: 1. to use the fqq to determine if the quality of friendships in children with nf1 is lower than the quality of friendships in unaffected children. 2. to use a disease severity scale and the fqq to determine if children who are less severely affected have higher friendship qualities than children who are more severely affected.

you (your) child will be asked to complete a short questionnaire (40 questions) about their relationship with their best friend. doctors will review your (child's) medical chart to find out how severe the disease is, so that this may be compared to the answers you have (your child has) given on the friendship questionnaire. this is an investigational study. about 90-100 children and adolescents with nf-1 will be asked to take part in this study. all will be enrolled at m.d. anderson.

Eligibility criteria:
inclusion criteria: 1) patients with a clinical diagnosis of neurofibromatosis, type 1 (nf-1) who are between the ages of 8 and 18 years will be eligible. patients must be english or spanish speaking (test instrument will be translated into spanish), and be able to read. exclusion criteria:

Keywords: neurofibromatosis quality of friendships disease severity questionnaire nf-1