Kornimate/medical-research-clean huggingface dataset:
open label study of iv brincidofovir in adult transplant recipients with adenovirus viremia

Conditions: Adenovirus

Summary: this is a randomized, controlled, open-label, multicenter study to evaluate the safety, tolerability, pharmacokinetic (pk), and adenovirus (adv) antiviral activity of multiple ascending doses of iv brincidofovir (bcv). approximately 30 eligible subjects will be sequentially enrolled into 1 of 3 planned cohorts. within each cohort, subjects will be randomized in a 4:1 ratio to receive iv bcv dosed twice weekly (biw) (on days 1, 4, 8, and 11) or to receive investigator-assigned standard of care (soc).


Eligibility criteria:
inclusion criteria: * be ≥ 18-years-old (or per local law or regulations on legal age of consent). * have received an allogeneic hematopoietic cell transplant (hct) within the previous 100 days. * have plasma adv dna viremia ≥ 1,000 copies/ml (via quantitative polymerase chain reaction assay; local results must be confirmed by the designated central virology laboratory). exclusion criteria: * diarrhea meeting the us national institutes of health (nih)/national cancer institute (nci) common terminology criteria for adverse events (ctcae) grade 2 or greater * acute graft versus host disease (gvhd) 1. nih stage 2 or higher acute gvhd of the gut (i.e., diarrhea \> 1,000 ml/day, or severe abdominal pain with or without ileus) or liver (i.e., bilirubin \> 3 mg/dl : \> 51 μmol/l) within 7 days prior to day 1 2. any nih stage 3 or stage 4 acute gvhd within 7 days prior to day 1 * concurrent human immunodeficiency virus or active hepatitis b or c infection * an estimated creatinine clearance of \< 30 ml/min, and/or use of renal replacement therapy within 7 days prior to day 1. * poor clinical prognosis, including active malignancy, irreversible organ failure, use of vasopressors, requirement for mechanical ventilation, resting oxygen saturation \< 88%, or pulmonary arterial oxygen (pao2) ≤ 55 mm hg without supplemental oxygen at any time within 7 days prior to day 1. * receiving or anticipated to start systemic cyclosporine immunosuppressant treatment during study participation. * received treatment with cdv within 14 days prior to day 1. * previous receipt of cell-based anti-adv therapy within 6 weeks prior to day 1 or prior receipt of an anti-adv vaccine at any time. * consumed food products containing sesame seeds, sesame oil, or dietary supplements containing sesamin within 3 days prior to day 1. * received any investigational drug within 28 days prior to day 1 or currently participating in another interventional study. * pregnant or breastfeeding.
evaluation of adam's forward bend test and smartphone application in screening of adolescent idiopathic scoliosis

Conditions: Adolescent Idiopathic Scoliosis

Summary: scoliosis is a lateral curvature of the spine when the cobb´s angle more than 10˚ on the frontal plane. curve detection before skeletal maturation gives a good opportunity for early treatment or prevention of curve progression. purpose of this study was to evaluate adam's forward bend test and scoliometer hd in screening of adolescent idiopathic scoliosis

the student was asked to stand erect, knees straight, feet at the same level and hands freely hanging. they was observed from the back for shoulders, pelvic, and knees level. student was asked to bend forward with his knees straight, feet together and hands freely and loosely hanged(forward bend test). scoliosis was detected with rib cage rotation and hump appearance (positive test). absence of hump appearance means negative test. after forward bend, the students were screened using the scoliometer hd application. the students were asked to bend forward with arms dangling and palms pressed together. the smart phone (scoliometer hd) was placed on the student back with the central dark area in the application placed on the spinous processes of the lumber and thoracic regions to measure the angle of trunk rotation. students with a scoliometer hd reading ≥7 degrees (≥20 ̊ cobb's angle) were referred to orthopedic consultation and their parents were informed about the findings of the screening by the school manager and social worker. then the data were collected for statistical analysis

Eligibility criteria:
inclusion criteria: * age range from 10 to 15 year. * males ( parents of girls refused their participation). * students who have structural scoliosis. exclusion criteria: * congenital deformities. * neuromuscular disorder (cerebral palsy and spinal muscle atrophy). * syndromic disorders (muscular dystrophy, osteogenesis imperfect and spinabifida).
pulsed electromagnetic field therapy versus transcutaneous electrical nerve stimulation in on post-herpetic neuralgia of the sciatic nerve

Conditions: Neuralgia,Postherpetic

Summary: background and purpose: post-herpetic neuralgia (phn) is the most frequent chronic complication of herpes zoster, resulting in post- infectious severe neuropathic pain. due to drug resistance severe pain; patients with phn suffer from reduced physical activities, social and psychological manifestations as well as decrease in the quality of life. the purpose of this research was to evaluate the efficacy of pulsed electromagnetic field therapy (pemft) versus transcutaneous electrical nerve stimulation (tens) in the treatment of post-herpetic neuralgia of the sciatic nerve. methods: in an eight weeks period of treatemnt, 52 patients were randomly and equally assigned into two groups. both groups received conventional physical therapy treatment protocol. moreover, group (a) has an additional tens application and group (b) had pemfs application. tens and the pemft were applied once daily, three times per week for 20 minutes for each session. assessment performed pre and post intervention using visual analogue scale (vas) and estimation of the carbamazepine intake (cmi).


Eligibility criteria:
inclusion criteria: * age from 30-40 years * history of herpes zoster more than 90 days * visual analogue scale is greater than or equal 5 out on a scale from 0 to 10 * all patients were on pain medication "carbamazepine" exclusion criteria: * uncooperative behavior * intellectual disability to complete the self-evaluation questionnaires
impact of preoperative 3d printed stoma placement on the quality of life of ostomy patients

Conditions: Ostomy

Summary: the making of an ostomy in patients is experienced as traumatic. the stoma changes body image, self-esteem and is responsible for increased anxiety. these changes affect the quality of life of patients. to reduce the negative impact of the stoma, patients are seen in preoperative consultation by the stoma nurses. this consultation allows to show the patients the appearance of a stoma (through a photograph), the equipment used and how it works. in 2016, mckenna et al. showed the interest of marking (with felt pen) the ostomy site on the abdomen in preoperative. in this study, patients with preoperative marking had a higher post-operative quality of life score than patients without marking (p=0.03). quality of life was assessed using the stoma-qol score. this quality of life score is specific for ostomy patients. it assesses 4 dimensions: sleep, intimate relationships, relationships with family and close friends, relationships with people other than family and close friends. this questionnaire includes 20 questions and has been validated in 5 languages including french. the aim of this pilot study is to evaluate the post-operative quality of life of ostomy patients who have benefited from a preoperative therapeutic education session with the placement of the 3d printed ostomy button versus felt-tip marking, during the 15 days prior to the operation.


Eligibility criteria:
inclusion criteria: * patient ≥ 18 years old, * first ileostomy with indication for temporary stoma placement, * patient with scheduled surgery, * patient who has the capacity to understand the protocol and has given consent to participate in the research, * patient with social security coverage. exclusion criteria: * patient \< 18 years old, * patient with an indication for placement of a permanent stoma, * emergency surgery patient, * patient who are pregnant, breastfeeding, or who have the potential to become pregnant without effective contraception, * patient under guardianship, curators or legal protection, * patient participating in another interventional clinical research protocol involving a drug or medical device.
non-thermal plasma for sebum reduction in oily facial skin

Conditions: Oily Skin

Summary: the aim of this study is to evaluate the efficacy and safety of argon-and nitrogen- non-thermal, atmospheric-pressure plasma (ntapp) for reduction of sebum excretion in healthy volunteers with oily facial skin.

excessive secretion of sebum contributes to several skin diseases associated with sebum glands, including acne. excessive sebum secretion can damage the skin barrier function by changing the composition of skin surface lipids, leading to the abnormal keratinocyte differentiation and hyperkeratosis in the follicular ostia. follicular hyperkeratosis can create anaerobic environment, leading to the proliferation of propionibacterium acnes. recently, several energy devices targeting sebaceous glands have been developed, but there is still a need for an effective and safe therapeutic tool for hyperseborrhea. non-thermal, atmospheric-pressure plasma (ntapp) has various biological effects. a recent study demonstrated ntapp-induced microscopic tissue reactions in the sebaceous glands from rat skin in vivo, suggesting that the potential effect of ntapp on the human sebaceous gland physiology, but the relevant data are lacking. in this study, investigators aim to assess the safety and efficacy of argon- and nitrogen-ntapp for reduction of sebum excretion in oily human facial skin.

Eligibility criteria:
inclusion criteria: 1. persons aged 19 to 40 years who are determined to have oily skin type. skin types were classified based on the sebum measurements by using measured using a sebumeter® (sm815; courage+khazaka electronic gmbh, cologne, germany) according to the manufacturer's guidelines as follows: \> 220 μg/cm2 on forehead and \> 180 μg/cm2 on cheeks, oily type; 100-220 μg/cm2 on forehead and 70-180 μg/cm2 on cheeks, normal type; \< 100 μg/cm2 on forehead and \< 70 μg/cm2 on cheeks, dry type. 2. people with mild acne-like skin whose upper limit is grade 1 (few lesions; no nodules, papules/pustules less than 1, few comedones) and grade 2(mild; no nodules, papules/pustules less than 5, some comedones) of the korean acne severity system 3. persons who skin color of type i to iii according to fitzpatrick skin type 4. persons who do not have inflammatory skin diseases on the facial skin 5. persons who have heard the purpose and contents of a clinical trial and voluntarily signed the consent form prior to the clinical trial 6. persons who can be monitored during a clinical trial period exclusion criteria: 1. persons who do not want this study or do not write a consent form 2. persons who have a history of hypertrophic scars, keloids, etc. 3. persons who have been using retinoid formulations within the last 1 month due to excessive sebum secretion or acne 4. persons who have a history of receiving treatments such as lasers or fillers on your face within the last 1 month 5. persons who is pregnant or lactating, or have a pregnancy plan within the expected trial period 6. other cases in which the study is considered difficult due to the judgment of the principal investigator
zenith® p-branch® and zenith® fenestrated aaa endovascular graft clinical study

Conditions: Aortic Aneurysm, Abdominal

Summary: the zenith® p-branch® and zenith® fenestrated aaa endovascular graft single-center study is a clinical trial approved by us fda to study the safety and effectiveness of the zenith® p-branch® and zenith® fenestrated aaa endovascular graft in the treatment of abdominal aortic aneurysms.


Eligibility criteria:
inclusion criteria: * abdominal aortic aneurysm \> 5.0 cm or 2 times the normal aortic diameter * abdominal aortic aneurysm with history of growth \> 0.5 cm in 6 months * penetrating juxtarenal aortic ulcer \> 10 mm in depth and 20 mm in diameter exclusion criteria: * age \< 18 years * life expectancy \< 2 years * pregnant or breast feeding * inability or refusal to give informed consent * unwilling or unable to comply with the follow-up schedule * additional medical restrictions as specified in the clinical investigation plan * additional anatomical restrictions as specified in the clinical investigation plan

Keywords: abdominal aortic aneurysm endovascular fenestration juxtarenal off-the-shelf pararenal
reduction of visual and auditory stimuli to reduce pain during venipuncture in premature infants.

Conditions: Premature; Pain, Procedural

Summary: the aim of the study is: to evaluate the efficacy of the reduction of visual and auditory stimuli on pain during venipuncture in premature newborns of 32-36 weeks of gestation.

background: the evidence for the efficacy of reducing sensory stimulation and its effect on pain in minor procedures has not been studied in depth. there are no studies that evaluate the reduction of visual and auditory stimuli in a combined way. impact: it is easy to incorporate the reduction of visual and auditory stimuli into nursing practice. aims: to evaluate the efficacy of the reduction of visual and auditory stimuli on pain during venipuncture in premature newborns of 32-36 weeks of gestation. design: open, randomized, non-blind parallel clinical trial. methods: study to take place at the neonatal intensive care unit at the germans trias i pujol university hospital in 2019-2021. 56 recently born babies between 32 and 36 weeks of gestation will participate. the dependent variable is level of pain determined using the premature infant pain profile (pipp). the intervention will be assigned randomly using the random.org software. data analysis will be carried out using the ibm spss v.25 software assuming a level of significance of 5%. the results of this study could have a direct impact on clinical practice.

Eligibility criteria:
inclusion criteria: * premature babies born between 32 and 36 weeks of gestation (both included). * haemodynamically stable. * require venipuncture and whose. * parents or legal guardians have signed informed consent forms. exclusion criteria: * gestational age inferior to 32 weeks. * treated with intravenous or oral analgesics, sedatives or relaxants. * critical status or haemodynamically unstable. * requiring invasive mechanical ventilation.

Keywords: pain premature visual stimuli auditory stimuli
study on bioavailability and pharmacokinetics of various doses of testosterone administered with and without dutasteride

Conditions: Hypogonadism; Hypogonadism, Male

Summary: the combination of testosterone and dutasteride is intended for use in hypogonadal men. this study will evaluate the bioavailability and pharmacokinetics of various doses of testosterone administered with and without dutasteride


Eligibility criteria:
inclusion criteria: * are healthy. * have a bmi within range of 19-32 kg/m2. * have not taken dutasteride for one year, or finasteride for the past 3 months. * have a screening psa \< 2.0ng/ml. exclusion criteria: * have had or have breast or prostate cancer, sleep apnea, psychiatric illness, or any other clinically significant current condition. * have a trigliceride level =500mg/dl. * have abnormal thyroid or hormone levels. * would donate more than 500 ml of blood over a 2 month period. * physician does not think it is a good idea for you to participate in the trial. * are unwilling to abstain from alcohol during the study. * have a positive urine drug screen test. * plan to change your smoking habits during the course of the trial. * have hepatitis c, hepatitis b, or hiv. * have a lab or ecg abnormality. * have high or low blood pressure. * have used of any investigational drug or device during the study or within 30 days prior to 1st dosing of study medication.

Keywords: testosterone men hypogonadism dutasteride dht androgen deficiency
hemiarch vs extended arch in type 1 aortic dissection

Conditions: Aortic Dissection

Summary: headstart is a prospective, open-label, non-blinded, multicenter, randomized controlled trial that compares a composite of mortality and re-intervention in patients undergoing hemiarch and extended arch repair for acute debakey type 1 aortic dissection. eligible patients will be randomized to one or the other surgical strategy and clinical and imaging outcome data will be collected over a 3 year follow up period.

debakey type 1 aortic dissections continue to have high operative mortality and morbidity and there is equipoise in available literature with regards to the best operative strategy and patient selection criteria. hemiarch repair is current standard of care in most centers but extended arch repair is gaining popularity aiming to address early post-operative malperfusion and improve long term aortic remodeling. headstart is a randomized controlled prospective trial of patients presenting to participating institutes with acute debakey 1 aortic dissection. patients will be enrolled and randomized into one of two groups - 'hemiarch repair' and 'extended arch repair'. pre-operative, early post-operative and long term follow clinical and ct imaging data will be collated on a centralized database and at a core lab respectively.

Eligibility criteria:
inclusion criteria 1. emergent surgical repair of acute debakey type 1 aortic dissection 2. age \>18 years and \<70 years 3. operating surgeon believes that both surgeries could be safe and effective exclusion criteria 1. hemodynamic instability/shock defined as systolic bp \< 90 mm hg 2. previous cardiac surgery with sternotomy or thoracic endograft placement 3. aortic arch diameter \> 6cm in which a concomitant arch replacement is judged necessary 4. procedures deemed to be "salvage operations" where the patient is unlikely to survive hospital discharge. 5. gcs \< 8 for more than 6 hours 6. history of cirrhosis. 7. history of chronic renal failure (baseline egfr \< 50) 8. metastatic malignancy 9. pregnancy
trial of supported employment versus uses supported employment

Conditions: Mental Disorders

Summary: the purpose of this study is to test the effectiveness of uses, a strengths-based enhancement to supported employment (se), as compared to supported employment alone.

the objective of this study is to test the effectiveness of supported employment plus using strengths in employment services (uses), an enhancement to supported employment that seeks to identify and increase the use of personal strengths, as compared to supported employment alone, for veterans with severe mental illness and/or substance abuse disorders. we hypothesize that rates of competitive employment will be greater in the experimental group than the control group. we also expect that individuals in the uses group will have greater job tenure, and will show greater improvements in recovery measures such as empowerment, self-efficacy and self-esteem.

Eligibility criteria:
inclusion criteria: * veteran * unemployed * referred by clinician to se services * able to provide informed consent

Keywords: rehabilitation, vocational virtues employment, supported veterans mentally ill persons
evaluation of the efficacy of distal gastrectomy for the treatment of gastric cancer (a case series)

Conditions: Gastric Cancer

Summary: case series of a retrospective study of patients operated for distal adenocarcinoma of the stomach, either by total gastrectomy or distal gastrectomy at ibn rochd university hospital in casablanca, with the analysis of outcome of patients on a follow up periode of three years and eight months.

thirty (30) patients were treated for gastric cancer and were included in this study. the average age was 64 years, the sex ratio 1.5. twenty eight patients underwent a distal gastrectomy and 2 patients underwent total gastrectomy. the median number of lymph nodes resected was 6 following distal gastrectomy versus 26 after total gastrectomy. resection margins were clean except for three patients who underwent a distal gastrectomy. postoperative complicationsoccured in 05 patients. they were mainly infectious, anastomotic leakage. two 2 cases of postoperative mortality (\<30 days) among patients with distal gastrectomy was noted. a progression to metastasis was found in 3 patients with subtotal gastrectomy, two of whom had insufficient lymph node clearance, compared to no cases of metastasis in patients with total gastrectomy.

Eligibility criteria:
inclusion criteria: patients bwith gastric cancer with histologic confirmation exclusion criteria: incomplete patients records

Keywords: gastric cancer, gastric adenocarcinoma, total gastrectomy, subtotal gastrectomy, distal gastrectomy.
non-invasive monitoring and serum marker study in children with cerebral edema

Conditions: Brain Edema

Summary: purpose of the study：this study aimed to evaluate the clinical significance of serum sur1, trpm4 and mmp-9 in the diagnosis of cerebral edema in children with cerebral edema admitted to picu by comparing them with ct results and perturbation coefficients, so as to provide biological indicators for clinical diagnosis of cerebral edema and provide targets for the treatment of cerebral edema in various diseases.

early and efficient use of various measures to control and monitor peripheral cerebral edema and intracranial pressure, timely and accurate adjustment of treatment plan to reduce the degree of cerebral edema and reduce intracranial pressure, can significantly improve the development of the disease and prognosis recovery. at present, the clinical diagnosis of cerebral edema is mainly through clinical manifestations and imaging examinations, and there is a lack of corresponding biological examination methods.purpose of the study：1.by analyzing the correlation between serum sur1, trpm4, mmp-9 and the electromagnetic disturbance coefficient, cranial ct results, glasgow coma score, s100-β, nse and prognostic score at 3 months of discharge, the clinical value of serum sur1, trpm4, mmp-9 and perturbation coefficient in the diagnosis, intracranial pressure monitoring, condition assessment and prognosis judgment of cerebral edema in children was explored.2.by analyzing the changes of the above indicators in various children with cerebral edema admitted to picu, the types of cerebral edema and the cellular and molecular mechanisms of cerebral edema caused by different diseases were explored.

Eligibility criteria:
inclusion criteria: * age 1-18 years old, male or female * diagnosed with cerebral contusion/cerebral hemorrhage/intracranial tumor postoperative / intracranial infection/septic encephalopathy/metabolic encephalopathy. * the research purpose, significance, risks, benefits, and informed consent of patients and their families to the study. exclusion criteria: * critically ill and not suitable for research. * those who are allergic to electrode sheets and do not cooperate. * age\> 18 years old or \< 1 month. * failure to obtain written permission from the guardian.