Kornimate/medical-research-clean huggingface dataset:
physician mental health study for medical trainees

Conditions: Mental Illness; Burnout Syndrome

Summary: the purpose of this study is to determine whether use of a suite of smart phone enabled mobile health devices can reduce burnout in medical trainees. such applications can then be used in more general populations with the same goal in mind.

wearable sensors and mental health platforms delivered via smartphones offer an opportunity to passively and actively acquire quantifiable signs and symptoms related to mental health status. these features include both physiological and cognitive performance measures. collectively they serve as a set of metrics whereby an estimation of a person's mental state can be gauged. additionally, use of these platforms allows those who are identified as high risk for mental illness to have targeted therapy delivered via their smartphone and if necessary connected with a suitable healthcare provider. applications of such technology platforms serve to potentially reduce the substantial morbidity and mortality in a population at increased risk for mental illness and burnout.

Eligibility criteria:
inclusion criteria: * trainee physician at scripps green hospital or clinic. * older than 18 years. * must be reliable, cooperative and willing to comply with all protocol-specified procedures. * able to understand and grant informed consent * have a pre-existing smart phone capable of running all study software. exclusion criteria: * has a significant medical condition that in the investigator's opinion may interfere with the study subject's optimal participation in the study. * known mental health condition including diagnosis of depression, schizophrenia, suicidality or anxiety disorder. * does not have suitable smart phone to allow all relevant software to run.

Keywords: depression suicide anxiety disorder burn out sleep quality stress
a study of naltrexone sr/ bupropion sr in overweight and obese subjects who are nicotine-dependent

Conditions: Nicotine Dependence; Overweight; Obesity

Summary: the purpose of this study is to determine whether a combination of naltrexone sr and bupropion sr is safe and effective in the treatment of nicotine-dependence in overweight and obese subjects.


Eligibility criteria:
key inclusion criteria: 1. female and male subjects must be 18 to 65 years of age; 2. have body mass index (bmi) greater than or equal to 27 and less than or equal to 45kg/m2; 3. have smoked an average of at least 10 cigarettes/day in the preceding year, with \< 3 month total abstinence period; 4. self-reported level of motivation to stop smoking ≥ 7, on a scale of 1-to-10; 5. at least moderately concerned about gaining weight after quitting smoking 6. women of child-bearing potential, must be non-lactating and agree to use effective contraception throughout the study period and 30 days after discontinuation of study drug; 7. able to comply with all required study procedures and schedule; 8. able to speak and read english; 9. willing and able to give written informed consent. key exclusion criteria: 1. obesity of known endocrine origin 2. serious medical condition 3. history of drug or alcohol abuse or dependence 4. use of excluded concomitant medications 5. history of surgical or device (e.g. gastric banding) intervention for obesity; 6. history or predisposition to seizures 7. pregnant or breast-feeding women or planning to become pregnant during the study period or within 30 days of discontinuing study drug; 8. planned surgical procedure that can impact the conduct of the study; 9. use of investigational drug, device or procedure within 30 days prior to screening; 10. participation in any previous clinical trial conducted by orexigen therapeutics; 11. any condition which in the opinion of the investigator makes the subject unsuitable for inclusion in the study.

Keywords: nicotine-dependence in overweight and obese subjects
comparison between the efficacy of residential and ambulatory weight loss programs for pediatric non-alcoholic fatty liver disease

Conditions: Pediatric Non-alcoholic Fatty Liver Disease

Summary: non-alcoholic fatty liver disease (nafld) has become the most prevalent chronic liver disease worldwide, paralleling the obesity pandemic. secondary to increasing rates of obesity in children and adolescents, the prevalence of nafld has more than doubled in the last decades and is now the most common pediatric liver disease. at present, lifestyle modification by dietary intervention and increasing physical activity is the mainstay of treatment for pediatric nafld. several studies have shown that lifestyle intervention and weight loss improve non-invasive markers of nafld. to the investigator's knowledge, data on fibrosis regression following lifestyle treatment in children and adolescents were lacking. the investigators therefore performed a prospective cohort study to investigate the impact of residential lifestyle treatment on liver steatosis and fibrosis in obese children and adolescents. as a follow-up, the investigators now aim to compare these findings with a cohort of well-characterized patients undergoing multidisciplinary, yet ambulatory, weight loss treatment. as such, the investigators will compare the outcomes in two prospective patient cohorts in this non-randomized observational study.


Eligibility criteria:
inclusion criteria: * enrolled in the lifestyle management program for obesity in one of the participating centres exclusion criteria: * syndromic obesity * evidence of liver disease of other causes (viral, auto-immune, genetic) * average daily alcohol consumption of \>20g/day * unvalid screening fibroscan * treatment with drugs which can induce liver steatosis or fibrosis (e.g. systemic corticosteroids, methotrexate)

Keywords: nafld liver fibrosis lifestyle management multidisciplinary treatment
psychoeducation to sick-listed individuals with mental health problems

Conditions: Stress, Psychological

Summary: in denmark, it is estimated that 35-45% of all sick leave registered citizens are on sick leave due to psychiatric sufferings. mental health conditions are of great consequence not only to the sick-listed individual but also to his/her family and to society in general and in socioeconomic terms. the aim of this project is to systematically compare psychoeducation with the various standard offers to sick listed individuals with mental health conditions provided by job centers in four municipalities. psychoeducation is employed within the psychiatric healthcare system and is defined as a group based treatment by means of educating participants about psychiatric conditions. in the present project, the employed psychoeducation focuses on psyche and work life, and its purpose is to impart knowledge about psychiatric conditions in order to provide the sick listed individuals with qualifications to understand, and, thereby, improve their own situation. among others, there will be information about the symptoms of various psychiatric conditions, diagnoses, and treatment options. furthermore, the participants will learn about specific, useful, cognitive tools in regards to the barriers and difficulties they might experience when reentering the work force and leave sickness absence behind. the project is designed as a randomized clinical trial in which the participants are offered either 1) psychoeducation as well as the standard offer to sick listed individuals provided by the municipality in which the individual lives or 2) the participants are offered merely the standard offer to sick listed individuals provided by the municipality. the target group consists of recently sick listed individuals with mental health issues - whether diagnosed or not. the individuals must be inhabitants of the municipalities of struer, lemvig, skive, and holstebro. the outcome measure is the determined as the duration of the sickness absence, the severity of the psychiatric condition, self-reported health, and 'locus of control´. these outcome measurements are assessed at baseline and after 3 and 6 months.


Eligibility criteria:
inclusion criteria: * a score of 5 or more on scl-8ad exclusion criteria: * sick listed due to psychiatric symptoms in a period of 3 months or longer in the last year * pregnant * has a flexible job * receive pension * not communicating in danish

Keywords: psychoeducation stress sickness absence psychiatric symptoms locus of control self reported health
effects of exercise training and age-crosslink breaker on cardiovascular structure and function

Conditions: Cardiovascular Disease; Aging; Endothelial Dysfunction; Physical Activity

Summary: healthy but sedentary aging leads to increased morbidity and mortality of cardiovascular disease. this is partly due to the accumulation of advanced glycation endproducts (ages) and the stiffening of the myocardium and arteries. new medication has been developed to break these age-crosslinks to improve cardiovascular compliance. the positive influence of regular physical activity is well known for cardiovascular disease and aging. therefore, what is the most effective intervention, physical exercise and/or new medication age-crosslink breakers, in improving the cardiovascular and cerebrovascular compliance and improving the endothelial function in healthy sedentary elderly.


Eligibility criteria:
inclusion criteria: * healthy sedentary elderly * age 65 yrs and older exclusion criteria: * cardiovascular disease * cerebrovascular disease * changes on ecg indicating cardiomyopathy or ischemia * no cardiovascular medication * diabetes mellitus * hypercholesterolemia * bmi \> 33 kg/m2 * intensive exercise \> 1 hour a week

Keywords: aging cardiovascular disease endothelial function physical activity advanced glycation endproducts age crosslink breakers
train new examiners via modified gingival margin plaque

Conditions: Dental Plaque

Summary: the purpose of this study is to train new examiners while testing two commercial products using our standard one-day brushing study regimen by measuring gingival margin plaque index.


Eligibility criteria:
inclusion criteria: * male or female volunteers 18-65 years of age * good general health * must sign informed consent form * must discontinue oral hygiene for 24-hrs.after initial appointment. * minimum of 20 natural uncrowned teeth (excluding third molars) must be present. * no history of allergy to personal care consumer products, or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study. exclusion criteria: * subjects unable or unwilling to sign the informed consent form. * medical condition which requires pre-medication prior to dental visits/procedures * moderate or advanced periodontal disease or heavy dental tartar (calculus). * 2 or more decayed untreated dental sites at screening. * other disease of the hard or soft oral tissues. * impaired salivary function (e.g. sjogren's syndrome or head and neck irradiation). * use of medications that can affect salivary flow * use of antibiotics or antimicrobial drugs within 30 days prior to study visit #1. * pregnant or nursing women. * participation in any other clinical study within 1 week prior to enrollment into this study. * use of tobacco products * subjects who must receive dental treatment during the study dates. * current use of antibiotics for any purpose. * presence of an orthodontic appliance. * history of allergy to common dentifrice ingredients. * immune compromised individuals (hiv, aids, immuno suppressive drug therapy)
mri of infrapatellar fat pad in osteoarthritis

Conditions: Osteoarthritis

Summary: in this study, the investigators use the clinical documentation and imaging data of mri to do research. clinical subjects were divided into two groups: osteoarthritis patients and healthy controls without osteoarthritis. differences of mri data were studied between two groups.

in this study, the investigators applied high precision mri technique (with as less as a slice thickness of 0.35 mm and without inter-slice gap), and calculated not only the ipfp maximal sagittal area and ipfp volume, but also the quantitated signal, and compared the differences between healthy controls and osteoarthritis patients. this is an observational cross-sectional study without specific interventions to the subjects. mri is a regular examination in our hospital. and all subjects are included for the reasons of osteoarthritis (need mri) and healthy controls (pain but not osteoarthritis, also need mri). the investigator does not assign specific interventions to the subjects of the study.

Eligibility criteria:
inclusion criteria: * patients with clinical knee osteoarthritis; * the healthy controls who require mri test. exclusion criteria: * contraindications to magnetic resonance imaging; * rheumatoid arthritis patients; * gout; * hemophilic arthritis; * subjects who take non-steroidal anti-inflammatory drugs (nsaids); * subjects who take lipid-lowering agents; * subjects who have the history of knee trauma; * subjects who have the history of knee operation; * subjects who have the disease of musculoskeletal tumor near knee; * subjects who have joint loose bodies.
the predictive value of clinical data on perioperative and postoperative risk events in patients with head and neck artery stenosis

Conditions: Postoperative Risk Factors for Patients With Carotid Artery Stenosis

Summary: the predictive value of clinical data on perioperative and postoperative risk events in patients with head and neck artery stenosis


Eligibility criteria:
inclusion criteria: * (1) all enrolled patients were diagnosed with clear head and neck artery stenosis and a risk event after head and neck revascularization; (2) location of lesion: origin of internal carotid artery, bifurcation of internal and external carotid arteries; (3) patients with symptomatic head and neck artery stenosis and dangerous events after head and neck blood flow reconstruction, and with a degree of stenosis ≥ 70% on non-invasive examination or stenosis ≥ 50% found on angiography; (4) asymptomatic head and neck artery stenosis and risk events after head and neck revascularization, with a degree of stenosis ≥ 70% on non-invasive examination or stenosis ≥ 60% found on angiography; (5) asymptomatic head and neck artery stenosis and dangerous events after head and neck blood flow reconstruction, with a non-invasive examination of stenosis degree less than 70%, but angiography or other examinations indicate that the stenosis lesion is in an unstable state; (6) symptomatic head and neck artery stenosis and risk events after head and neck revascularization, non-invasive examination of head and neck artery stenosis and risk event degree after head and neck revascularization at 50% to 69% exclusion criteria: * (1) patients with poor overall condition and intolerance to general anesthesia; (2) patients with mental illness or severe mental illness; (3) severe respiratory system diseases; (4) pregnant and lactating women; (5) participating in another clinical study; (6) patients with advanced tumors or those who are expected to die within one year;
a biomarker for personalized care in post-stroke spatial neglect

Conditions: Spatial Neglect; Stroke

Summary: more than 30,000 veterans are hospitalized for stroke each year, and in the critical first months of recovery, at least half are disabled by abnormal 3-d spatial function (spatial neglect). their self-care, mobility, and ability to return home are severely limited.

spatial neglect (sn)is an underdiagnosed stroke-related condition--and a specific core set of symptoms--aiming spatial neglect-- may have a major adverse effect on outcome. these same symptoms may predict excellent response to spatial neglect therapy. the investigators seek to develop a biological parameter for treatment assignment. in this two-year study, the investigators will enroll 45 people with right brain stroke who are at high risk of sn. the investigators will examine clinical brain images, behavioral assessment and research brain images at baseline and recovery at 3 and 6 months after study entry.

Eligibility criteria:
inclusion criteria: * stroke survivors \>18 years * 1-8 months post-stroke * can undergo testing and give informed consent exclusion criteria: * other serious * chronic neurological disorders * evidence of other serious strokes * inability to undergo testing or give informed consent
prevention of shaken baby syndrome

Conditions: Child Abuse; Shaken Baby Syndrome

Summary: this research project seeks to implement an early intervention program that can be effective in the prevention of shaken baby syndrome (sbs) and infant abuse. our hypothesis is that the period of purple crying intervention program can reduce shaking and abuse of infants through changes in knowledge, attitudes and behaviors about early infant crying, especially inconsolable crying. in this 3-year project, we will implement and evaluate an intervention program in selected prenatal classes, hospitals, and primary care pediatric practices. in this randomized, controlled trial, we will enroll a total of 3000 women/families who are about to give birth or have just given birth to a healthy infant. at each of the three sites (newborn nursery, pediatrician offices and prenatal classes), we will enroll 1000 subjects. half of all subjects will receive intervention materials (a video, pamphlet and bib/burp cloth) about infant crying. the other half, the control group, will receive comparable materials on infant safety. all subjects will be asked to complete a brief questionnaire at the time of enrollment (pre test), review the materials they receive, complete the baby's day diary for 4 days when the infant is 5 weeks of age and complete a telephone questionnaire (post test) when the infant is 8 weeks of age.

the specific goals of the program are: 1. to change the understanding (i.e., knowledge and attitudes) and reduce the frustration of parents of new infants about the normality of the frustrating properties of crying; 2. to change the behavior of parents to increase caregiving contact in response to crying but to 'walk away' if frustrated; 3. to provide parents with the ability to communicate to other caregivers (relatives, baby-sitters) the knowledge and behavior to reduce frustration induced by inconsolable crying; 4. to provide effective knowledge, skills and teaching materials to health care providers in direct contact with parents concerning crying, shaking and abuse; 5. to reduce the incidence of physical abuse and shaken baby syndrome under one year; 6. to have the period of purple crying program adopted as a nationwide early intervention project.

Eligibility criteria:
inclusion criteria: * subjects must be new parents or parents to be who are either: 1) attending participating prenatal classes; 2) delivering a baby at the participating hospital; or 3) visiting a psprn (puget sound pediatric research network) pediatrician for infant care. * only parents of infants born at \> 34 weeks gestation are eligible. exclusion criteria: * parents of infants who have serious medical conditions. * parents who don't speak and read english. * parents of infants born at \< 34 weeks gestation.

Keywords: abuse
deformation imaging by strain in chronic heart failure over gliflozins: an echocardiographic register on sodium-glucose cotransporter-2 inhibitors

Conditions: Sodium-GLucose coTransporter-2 Inhibitors; Heart Failure With Reduced Ejection Fraction

Summary: it is an observational, cohort, prospective, multicentre, italian, non-profit study, with the aim of evaluating the modification of conventional and advanced echocardiographic parameters, focusing on speckle tracking and three-dimensional echocardiography (optional), in patients with hfref after treatment with sglt2i dapagliflozin and empagliflozin. participation in the study will last for approximately 18 months, and a total of 300 patients will be enrolled at the various research centers. the enrolled patients will undergo a first evaluation in which the anamnestic, clinical and conventional and advanced echocardiographic data will be recorded. at this point, the patient will start sglt2i. after starting sglt2i, a second evaluation will be carried out with a cardiological visit at 6 months, in which the same data listed above will then be recorded. at the end of the evaluation, the clinical follow-up will be continued for the duration of 1 year, in number and frequency according to clinical indication.


Eligibility criteria:
inclusion criteria: 1. providing informed consent prior to any specific study procedure 2. female or male outpatient patients \> 18 years 3. have heart failure and left ventricular ejection fraction \<= 40%, according to the esc definition 4. already on therapy with an angiotensin converting enzyme (ace) inhibitor or sacubitril / valsartan, a beta-blocker and mineralocorticoid receptor antagonist (mra) and be initiated for treatment with sglt2i for therapy optimization exclusion criteria: 1. involvement in study planning and / or conducting (applies to both investigator staff and study site staff) 2. age \<18 years 3. for women only - ongoing pregnancy (confirmed with positive pregnancy test) 4. for women only - breastfeeding 5. poor quality of echocardiographic images which compromises a correct speckle tracking analysis 6. failure to sign informed consent. 7. previous treatment with sglt2i.

Keywords: echocardigraphy speckle tracking strain sglt2i
safety and efficacy of azelaic acid foam, 15 % in papulopustular rosacea

Conditions: Papulopustular Rosacea

Summary: the purpose of this study is to assess the safety and efficacy of azelaic acid (aza) foam, 15% topically applied twice daily for 12 weeks in subjects with papulopustular rosacea compared to its vehicle.

to determine the efficacy of aza foam, 15% compared to vehicle topically applied twice daily in papulopustular rosacea evaluated by therapeutic success rate according to investigators global assessment (iga) and change in inflammatory lesion count from baseline to end of treatment. evaluation of all adverse events will be covered in adverse events section.

Eligibility criteria:
inclusion criteria: * diagnosis of papulopustular rosacea * free of any clinically significant disease, which could interfere with the study * male or female subject aged ≥ 18 years * willingness of subject to follow all study procedures * signed written informed consent before any study-related activities are carried out exclusion criteria: * subjects who are known to be non-responders to azelaic acid * presence of dermatoses that might interfere with rosacea diagnosis * ocular rosacea; phymatous rosacea; subjects with plaque-type rosacea lesions, papulopustular rosacea that requires systemic treatment * topical use of any prescription or non-prescription medication to treat rosacea within 6 weeks prior to randomization and throughout the study * systemic use of any prescription or non-prescription medication to treat rosacea (retinoids within 6 months, tetracycline within 2 months, corticosteroids, erythromycin, azithromycin, and/or metronidazole within 4 weeks) prior to randomization and throughout the study * facial laser surgery for telangiectasia (or other conditions) within 6 weeks prior to randomization * known hypersensitivity to any ingredients of the investigational product formulation * participation in another clinical research in parallel or within the last 4 weeks before randomization in this study * any condition or therapy that in the investigator's opinion may pose a risk to the subject or that could interfere with any evaluation in the study

Keywords: rosacea