Kornimate/medical-research-clean huggingface dataset:
cannabis for chronic headaches in adolescents: the can-cha trial

Conditions: Chronic Migraine

Summary: chronic headaches are a major cause of disability among adolescents. cannabis products have supported the management of headaches in adults and may play a role in pediatric chronic pain. we propose a multisite, open-label, tolerability study conducted across three centers in canada of cannabidiol-enriched cannabis herbal extract in adolescents (ages 14 to 17 years old) with chronic headaches. the study includes a one month baseline assessment, four months of escalating treatment doses and a weaning period. our primary outcome is tolerability defined as the number and severity of reported adverse events.


Eligibility criteria:
inclusion criteria: to be eligible to participate in this study, an individual must meet all of the following criteria: 1. adolescents aged between 14-17 years of age at the time of screening. 2. diagnosed with chronic migraine according to ichd-3: headache (migraine-like or tension-type like) occurring on 15 or more days per month for more than 3 months which on at least 8 days per month have features of migraine headache. \[121\] 3. failed at least two treatment options on the grounds of safety (tolerability) and/or efficacy, including but not limited to antidepressant (tricyclic antidepressant or selective norepinephrine reuptake inhibitor), magnesium, gabapentinoids topiramate and/or non-pharmacological therapies. 4. females who have reached menarche should have a negative pregnancy test during screening. 5. must be willing to engage with psychology and physiotherapy throughout the trial as appropriate. exclusion criteria: 1. as per the investigator judgement, the participant is not an ideal candidate due to a personal issue or medical condition that is likely to impede in the successful completion of the study 2. participants with a history of post-concussion headache or new daily persistent headache 3. participants with a diagnosis of medication overuse headache 4. participants with cardiac, renal or hepatic disease (assessed by the site investigator) 5. participants with complex regional pain syndrome-ii 6. participants with abnormal ecg findings at baseline (as determined by the investigator) 7. participants who are on the following medications: opioids, antipsychotics, antimanic, barbiturates, benzodiazepines, muscle relaxants, sedatives, or tramadol. 8. participants with developmental delay or impairments including autism, cerebral palsy or intellectual disability. 9. participants with a personal or family history of schizophrenia or psychotic disorders 10. participants who are pregnant or breast/chest-feeding or plans to become pregnant within the study period or within three months of interventional product discontinuation 11. participants who cannot commit to using contraception and refraining from recreational cannabis use and driving throughout the study period 12. participants with known allergy to cannabinoids and/or palm/coconut oil

Keywords: adolescents children cannabis migraine cannabidiol tetrahydrocannbinol
clinical study of real time colorectal polyp diagnosis during colonoscopy - the valid colonoscopy study

Conditions: Colorectal Neoplasm; Colonic Polyps

Summary: the investigators hypothesize that high definition colonoscopy with close focus narrow band imaging features has a high diagnostic accuracy for colorectal polyp histology, and can replace formal pathologic assessment in cases of high diagnostic confidence.

a recent single arm prospective cohort study suggested that high definition colonoscopy with narrow band imaging is an acceptable strategy to diagnose polyp histology and determine future surveillance intervals. endoscopic proficiency in macroscopic features to differentiate polyp histology can be attained in a relatively short time period. a new high definition colonoscope with close focus narrow band imaging features may further improve diagnostic accuracy for polyp differentiation, and can replace formal pathologic assessment in cases of high diagnostic confidence. primary aim: compare the diagnostic accuracy of high definition narrow band imaging colonoscopy with and without close focus features for the macroscopic differentiation of neoplastic and non-neoplastic colorectal lesions using histopathologic diagnosis as the reference standard. secondary aims: compare diagnostic characteristics of the colonoscopes, measure concordance of high confidence and accuracy, compare accuracy of predicted versus actual surveillance interval recommendations, perform a cost-effective analysis of endoscopic versus pathologic diagnoses, and measure complications.

Eligibility criteria:
inclusion criteria: * adult patients referred for routine colonoscopy exclusion criteria: * known inflammatory bowel disease * personal or family history of polyposis or non-polyposis syndrome * presentation for emergency endoscopy * inability to remove polyp due to coagulopathy or thrombocytopenia * inability to provide informed consent

Keywords: colonoscopy diagnostic imaging colorectal neoplasm primary prevention cost and cost analysis endoscopy
cystatin c and uncontrolled hypertension

Conditions: Uncontrolled Hypertension

Summary: hypertension is an underdiagnosed and undertreated disease in real-life. blood pressure and kidney functions are known to be closely related. increased serum level of cystatin c, a sensitive biomarker for renal function, seems to predict adverse cardiovascular events. the investigators aimed to evaluate the predictive value of serum cystatin c for control of hypertension in a community-based study.


Eligibility criteria:
inclusion criteria: * individuals who accept to participate to the survey * \> 18 years exclusion criteria: * individuals who are not able to complete the questionnaire * individuals who didn't give informed consent

Keywords: hypertension blood pressure cystatin c real-life kidney
assistive exoskeletons to enable wearable rehabilitation robotics

Conditions: Diabetic Foot Ulcer; Diabetic Foot Ulcer Associated With Type II Diabetes Mellitus

Summary: study will evaluate the use of lower-limb assistive exo-skeletons worn on the ankle and foot. participants will wear the exo-skeletons and walk in a safe environment. measurements will be taken to determine how the exo-skeletons affect the pressure on the feet of people with diabetic foot ulcer and how they walk.

study will evaluate the use of lower-limb assistive exo-skeletons worn on the ankle and foot. participants will include those with self-described history of diabetic foot ulcer and age-matched healthy volunteers. participants will wear the exo-skeletons and will be asked to walk 32 feet, and to stand quietly for 30 seconds. measurements will be taken to evaluate how the exoskeletons affect how people walk, and will also evaluate the pressure on the bottom of their feet. these measurements will be repeated multiple times to evaluate four different exo-tendon spring rates, and two sets of control shoes. exo-skeletons have been shown to reduce the pressure on the bottoms of people's feet and to reduce the effort to walk. this study is necessary to understand the contribution of different levels of exo-skeleton spring force to these effects.

Eligibility criteria:
inclusion criteria: * self-reported history of diabetic foot ulcer exclusion criteria: * unable to continuously ambulate/walk ≥ 40 feet without an assistive device, such as a cane or walker * signs/symptoms of an infected foot lesion/ulcer as determined by a basic foot exam * trans-metatarsal foot amputation or more significant amputation. * symptomatic for signs/symptoms of cardiovascular disease as determined from interpretation of the 2017 par-q+ (predicated on participant responses of "yes" indicating symptomatic/unstable medical conditions to page 2 and page 3 of the 2017 par-q) * participants will be excluded from this study if they demonstrate pre-participation, or chronic, signs/symptoms of hypoglycemia: confusion, unusual headache, unusual visual disturbances, self-reported mental dullness, shakiness, self-reported weakness, abnormal sweating, undue nervousness/anxiety, and/or tingling of the mouth, toes, and/or fingers or if they answer yes to question 5b and 5c of the 2017 par-q+ . * participants will be temporarily excluded from this study if they are symptomatic for acute illness such as cold or fever. if the participant is symptomatic for acute illness such as cold or fever, participation will be reconsidered upon illness resolution. * if participants answer yes to question 4a of the 2017 par-q+ and if they demonstrate pre-study participation resting blood pressure \ 140/90 mmhg .
inspiratory muscle training in sarcoidosis

Conditions: Sarcoidosis

Summary: respiratory muscle weakness results with decreased exercise capacity, worse fatigue, dyspnea and quality of life in patients with sarcoidosis. however, no study investigated the effects of inspiratory muscle training (imt), therefore effects of imt on outcomes in patients with sarcoidosis were investigated.

patients were diagnosed with sarcoidosis according to the criteria of the latest american thoracic society (ats)/european respiratory society (ers)/world association of sarcoidosis and other granulomatous (wasog) disorders statement on sarcoidosis. primary outcome measurement was respiratory muscle strength, secondary outcomes were, exercise capacity quality of life, fatigue and depression.

Eligibility criteria:
inclusion criteria: * clinically stable * under standard medication * stage i and iv * no change in medications over three months exclusion criteria: * cognitive disorders * current corticosteroid use * having co-morbidity to prevent performing imt * acute infection * orthopedic and neurological problems

Keywords: sarcoidosis inspiratory muscle strength exercise capacity quality of life
intrapartum glucose control and risk of neonatal hypoglycemia

Conditions: Gestational Diabetes Mellitus in Pregnancy; Pregestational Diabetes Mellitus; Neonatal Hypoglycemia

Summary: the purpose of this study is to assess whether a liberal intrapartum glycemic target range compared to usual care standard control ranges will lead to a decrease in the rate of neonatal hypoglycemia among pregnant patients in labor with diabetes.

neonatal hypoglycemia is a leading cause of admission to the neonatal icu (nicu) and is associated with increased costs, separation from mothers, and when severe, long term neurological sequelae. prior research has suggested an association between intrapartum maternal glucose and the risk of neonatal hypoglycemia, so current insulin administration protocols aimed to maintain the blood glucose close to 100mg/dl. however, recent studies have found inconsistent evidence of a relationship between intrapartum maternal glucose and neonatal hypoglycemia, furthermore, on review of previously established protocols, improved maternal glucose control came with an increased frequency of neonatal hypoglycemia. thus, these findings have suggested that relaxing the intrapartum goals for maternal glucose may be associated with improved neonatal outcomes. few randomized controlled trials (rcts) exist in evaluating neonatal outcomes comparing liberal versus tight intrapartum glycemic control. recent rcts have found that tight maternal glucose control in labor was associated with lower mean neonatal blood glucose levels in the first 24 hours of life. while another recent rct found that a permissive blood glucose (up to 180mg/dl) threshold was associated with equivalent neonatal blood glucose levels when compared to the standard, strict thresholds (up to 110mg/dl). in this study, participants will be recruited at delivery planning outpatient visits or at admission to labor and delivery and stratified by type of diabetes into two groups, either type 1 diabetes or gestational diabetes(gdm)/type 2 diabetes. they will then be randomized to one of two intervention groups. the liberalized treatment group will have a target glucose range 70 - 160mg/dl and receive treatment via insulin drip will be initiated if the blood sugar exceeds the upper bound. the standard treatment group will have a glucose target glucose range 70 - 110mg/dl and receive treatment via insulin drip will be initiated if the blood sugar exceeds the upper bound. the specific aim of this project is to determine the effectiveness of liberalized intrapartum glycemic targets in reducing the incidence of neonatal hypoglycemia.

Eligibility criteria:
inclusion criteria: * pregnant patients with pre-gestational (type 1 or type 2) or gestational diabetes * singleton gestations * greater than or equal to 35 weeks gestation * planned for vaginal delivery at the university of pittsburgh medical center magee-womens hospital (upmc mwh) exclusion criteria: * major fetal anomalies anticipated to require nicu admission * planned cesarean delivery

Keywords: gestational diabetes pregestational diabetes neonatal hypoglycemia intrapartum glucose
vorinostat and palliative radiotherapy

Conditions: Pelvic Cancer; Radiotherapy

Summary: phase i study. side-effects when combined with standard palliative radiotherapy.


Eligibility criteria:
inclusion criteria: * pelvic malignancy * palliative radiation treatment planed * ecog \<3 * age\>18 years exclusion criteria: * previous pelvic radiotherapy * uncontrolled diarrhea * insulin-dependent diabetes mellitus * bmi\<18.5

Keywords: palliative treatment max. tolerable dose
clinical trial of desmopressin on nocturia in obstructive sleep apnoea patients

Conditions: Nocturia; Obstructive Sleep Apnoea

Summary: the purpose of the study is to evaluate the efficacy of desmopressin on symptoms of nocturia in patients with obstructive sleep apnoea (osa). the improvement of sleep quality and the quality of life will be measured.

nocturia is one of the commonest urinary symptoms in elderly and in patients with obstructive sleep apnoea (osa). according to the international continence society (ics) definition, nocturia is defined as "the complaint that the individual has to wake at night one or more times to void" . it implies a continuum beginning from what might be considered normal, to a bothersome state. bothersome nocturia is a common and age-dependent condition. a prevalence ranging from 48.6% to 77% were reported in the literature. pathogenesis of nocturia is multi-factorial, and has closely related to osa. osa patients generate negative intrathoracic pressure during sleep, this leads to increased venous return and distension of the right atrium. this leads to an increase of hormone secretion, namely atrial natriuretic peptide (anp). anp causes increased sodium and water excretion, and inhibits the secretion of antidiuretic hormone. all of the above factors results in an increased nocturnal urine production and nocturia. middle-aged men with osa always present to urology clinic with lower urinary tract symptoms with predominant nocturia. many a time they were treated as benign prostatic hyperplasia with multiple medications with suboptimal response. the underlying genuine pathology of osa-related nocturia is overlooked. desmopressin is an analogue of antidiuretic hormone, it is the pharmacological therapy of choice for patients with nocturia where night-time polyuria is present. in this study, the investigators would like to evaluate the efficacy of desmopressin on symptoms of nocturia in patients with obstructive sleep apnoea (osa). the improvement of sleep quality and the quality of life will be measured.

Eligibility criteria:
inclusion criteria: * adult male or female patient (aged\</=65 years old) * obstructive sleep apnoea diagnosed by sleep study * stable treatment on obstructive sleep apnoea and / or luts * nocturia on average more than once per night * having the ability to communicate and comply with the requirements of the study exclusion criteria: * presence of urethral strictures and neurogenic bladder dysfunction * clinical evidence of bladder stones, bladder tumor or an active urinary tract infection * history of prostate cancer or prostate specific antigen (psa) level \> 10ng/ml or suspicious of prostate cancer on digital rectal examination (dre), unless a transrectal biopsy of prostate has been performed and the presence of prostate cancer has been excluded. * patient on intermittent self-catheterisation * recent start or change of treatment on obstructive sleep apnoea and / or nocturia * uncontrolled medical problems: e.g. diabetes mellitus or diabetes insipidus * hyponatraemia * pregnancy

Keywords: nocturia obstructive sleep apnoea desmopressin
vaginal progesterone versus 17-alpha-hydroxyprogesterone caproate in placenta previa

Conditions: Placenta Previa

Summary: purpose to evaluate the effects of vaginal progesterone versus 17-alpha-hydroxyprogesterone caproate for prevention of emergent cesarean delivery in asymptomatic pregnant women with placenta previa

the study will be a randomized open-label clinical trial conducted at a tertiary university hospital outpatient clinic and some private settings at aswan governorate, egypt, between january 2019 and march 2022. the authors will include women who asymptomatic pregnant women with a diagnosed placenta previa at 26-28 weeks gestation. they will be randomized into three groups: group i (vaginal progesterone suppositories ), group ii (received an intramuscular dose of 250 mg 17-alpha-hydroxyprogesterone caproate(17-ohpc) once a week) and group iii(control group). in each group, follow-up visits were performed every week then admission was done at 36 weeks at our university hospital. scheduled caesarian section was done at completed 37 weeks unless otherwise required.

Eligibility criteria:
inclusion criteria: * gestational age 26-28 weeks of gestation. * definite and reliable diagnosis of placenta previa (defined as the presence of a placenta within 2 cm of the internal os), using a transvaginal ultrasound scan exclusion criteria: * multiple pregnancies. * women at high risk of preterm labor e.g. history of spontaneous preterm labor or preterm prelabour rupture of the membranes (pprom). * severe antepartum hemorrhage and/or hemodynamic instability that necessitates urgent -intervention and delivery. * women who have been maintained on progestin therapy since early pregnancy for whatever reason.

Keywords: cesarean section placenta previa antepartum hemorrhage vaginal progesterone 17-alpha-hydroxyprogesterone caproate
long- term follow-up of extraction socket management

Conditions: Tooth Loss

Summary: twenty-nine patients needing single tooth replacement in aesthetic area were treated by extraction and socket preservation with saddle connective tissue graft between september 2009 and february 2012. computed tomography scan were taken at baseline just after the surgery and 3 months later. long- term evaluation of this particular socket management procedure was evaluated by recalling successfully seventeen of theses patients in june 2016. at this time, a clinical and radiographical consultation was done and cone beam ct was taken. horizontal and vertical bone dimensional changes were then assessed thanks to 3d imaging analysis and esthetic and implants outcomes were evaluated.


Eligibility criteria:
inclusion criteria: * good general health (asa 1, 2) * controlled periodontitis * \>18 years of age or signed consent by the parents * smoking history of\<10 cigarettes per day * signed informed consent. exclusion criteria: * pregnancy or lactation * concurrent participation in another trial * bone disease or the use of medications that interfered with bone metabolism * history of head and neck radio- therapy * presence of dehiscence or fenestration on bone wall of the socket.
the radiation oncology registry and biosample repository

Conditions: Neoplasia

Summary: the goal of this study is to establish a registry and biosample repository (defined as blood, urine, and tumor specimens) in patients with a cancer and/or benign tumor diagnosis undergoing radiotherapy.


Eligibility criteria:
* anyone age 18 and above with a cancer and/or benign tumor diagnosis undergoing radiotherapy * able to sign consent
prevalence of temporomandibular joint disorders among egyptian university postgraduate students

Conditions: Temporomandibular Joint Disorders

Summary: the study will take place in egypt. postgraduate students from different faculties of the egyptian universities will participate. the study will begin in decemberr 2020.

matching criteria and allocation ratio the planned study a single arm cross sectional study, in which the prevalence of students of tmd will be reported. the association between tmd and other variables will be also studied. gender, age, psychological stress, non-nutritional oral habits as nail biting, lip biting, object biting and grinding of teeth (bruxism \& clenching), para-functional habits, such as intensive gum chewing, leaning of the chin on the hand and mouth breathing , previous dental treatment and previous jaw trauma will be all studied. data sources and management data sources, the answered questionnaires and subsequent spread sheets will only be shared by the team members. ddressing potential sources of bias selection bias: sampling will be convenient sampling, questionnaires will be handed to the students, otherwise an email will be sent to all the students through their university email addresses if covid-19 situation prevails. statistical methods statistical methods all confounders, effect modifiers and exposures will be controlled for by crude and adjusted regression analyses, where the primary analysis will be the adjusted one. failure to do so as a result of violating principles of a regression model will call for a subgroup analysis, where a student t test will be used for the comparison between the subgroups. it is also planned to study the interactions between the variables via anova test if the data show normal distribution. participants with missing data will be excluded. - cross-sectional study-since the planned sampling method is cluster sampling, where the design effect factor becomes greater than 1. sensitivity of the results to adjusted and crude analysis will be done.

Eligibility criteria:
inclusion criteria: 1. postgraduate students in egyptian universities 2. age ranges from 18-45 years 3. males and females exclusion criteria: -