Kornimate/medical-research-clean huggingface dataset:
simulation of consecutive day shift work

Conditions: Hyperthermia; Fatigue; Heat

Summary: the purpose of this study is to determine differences in physiological recovery between two consecutive days of simulated fire suppression work. the secondary purpose is to determine differences in heat gain and heat loss between two consecutive days of simulated fire suppression work. subjects will complete two consecutive days of simulated structural firefighting shift work, 24 hours apart. before and after each laboratory visit, subjects will continuously wear a holter monitor and ambulatory blood pressure monitor to quantify parasympathetic tone and recovery from work.


Eligibility criteria:
inclusion criteria: * 18-39 y old men and women * self-reported to be healthy exclusion criteria: * history of any cardiovascular, neurologic, renal, or metabolic disease * current tobacco use or regular use within the last 2 years * taking medications with known thermoregulatory or cardiovascular effects (e.g., aspirin, acetaminophen, ibuprofen, beta blockers, diuretics, psychotropics, etc.) * history of exertional heat stroke * currently pregnant or breastfeeding, or planning to become pregnant during the study * inability to follow the rules of the protocols or understand the consent form * no contraindications for ingestion of the gastrointestinal temperature pill
concomitant utilization of radio frequency energy for atrial fibrillation (cure-af) study

Conditions: Atrial Fibrillation

Summary: this investigation is a prospective, nonrandomized multicenter clinical trial evaluating the outcome of patients with atrial fibrillation (af) requiring concomitant open heart surgery plus the cardioblate surgical ablation system using the modified maze iii procedure. the trial population includes patients requiring valve replacements or repairs, atrial septal defect (asd) repairs, patent foramen ovale (pfo) closure or coronary artery bypass graft (cabg) procedures. the study objectives are to demonstrate that the medtronic cardioblate surgical ablation system can safely and effectively treat permanent af patients.


Eligibility criteria:
inclusion criteria: 1. patients must have a documented history of permanent af (cardioversion failure) as defined by the acc/aha/esc guidelines. 2. concomitant indication (other than af) for open-heart surgery for one or more of the following: * mitral valve repair or replacement * aortic valve repair or replacement * tricuspid valve repair or replacement * atrial septal defect (asd) repair * patent foramen ovale (pfo) closure * coronary artery bypass procedures 3. greater than or equal to 18 years of age 4. able and willing to comply with study requirements by signing a consent form 5. must be able to take the anticoagulant warfarin (coumadin) exclusion criteria: 1. wolff-parkinson-white syndrome 2. nyha class = iv 3. left ventricular ejection fraction ≤ 30% 4. need for emergent cardiac surgery (i.e. cardiogenic shock) 5. previous ablation for atrial fibrillation, av-nodal ablation, or surgical maze procedure 6. contraindication for anticoagulation therapy 7. left atrial diameter \> 7.0 cm 8. preoperative need for an intra-aortic balloon pump or intravenous inotropes 9. renal failure requiring dialysis or hepatic failure 10. life expectancy of less than one year 11. pregnancy or desire to be pregnant within 12 months of the study treatment. 12. current diagnosis of active systemic infection 13. documented mi 6 weeks prior to study enrollment

Keywords: permanent atrial fibrillation surgical rf ablation permanent atrial fibrillation
treatment intensification for hiv infected patients with multi-drug resistant virus

Conditions: HIV Infections

Summary: drug resistance may develop in hiv infected patients who take anti-hiv drugs, but most patients do well if they continue taking them. the purpose of this study is to test the effectiveness of a short, intensified course of anti-hiv drugs for controlling hiv infection in adults who have virus resistant to multiple drugs.

while an hiv infected patient is taking highly active antiretroviral therapy (haart), drug-resistant hiv may emerge; however, it has been observed that hiv viral loads while on haart are usually lower than baseline levels. expansion of the t cell population during early haart may explain this phenomenon. it is hoped that a short but aggressive haart regimen to treatment-experienced patients who have drug-resistant virus will produce immune cells that will better control drug-resistant virus. this study will determine if a 6-month haart regimen intensified by enfuvirtide (t-20) is effective in eliciting a stronger immune response against drug-resistant virus. this study will last 48 weeks. all participants will receive t-20 as part of a haart intensification regimen; haart other than t-20 will not be provided by the study. there will be 17 study visits. prior to beginning treatment intensification, participants will have weekly study visits for three weeks. once treatment intensification has started, participants will be followed weekly for four weeks, then weekly for four weeks after treatment intensification, then monthly thereafter. blood collection will occur at each visit.

Eligibility criteria:
inclusion criteria: * hiv viral load of more than 1000 copies/ml * on stable antiretroviral therapy * have multidrug resistance exclusion criteria: * require immunomodulatory drugs

Keywords: hiv drug resistance viral fitness hiv specific immunity t cell activation drug resistant viremia treatment experienced
effect of açaí juçara consumption on endothelial function and arterial stiffness

Conditions: Overweight and Obesity

Summary: this study evaluates the consumption of açaí juçara pulp in endothelial function and arterial stiffness in overwheight and obese individuals. half of participants will receive a hipocaloric diet and two açaí juçara pulps for daily consumption, while the other half will receive just a hipocaloric diet.

obesity is the most prevalent nutritional disease and a growing public health problem worldwide. this clinical condition is an established risk factor for cardiovascular diseases. açaí juçara is a brazilian fruit, rich in antioxidants, like anthocyanin. this compound have antioxidative and vasodilatory properties. prospective studies have shown that the antioxidant present in berries can improve vascular health, like endothelial function, measured by flow mediated dilatation (fmd) and arterial stiffness, measured by pulse wave velocity (pwv).

Eligibility criteria:
inclusion criteria: * sedentary lifestyle * overwheight or obesity "1" diagnostic (bmi \>25kg/m² and \<35kg/m²) exclusion criteria: * alcoolism * smoking * diagnostic of diabetes mellitus or coronary artery disease * use of statin therapy * cardiovascular diseases * infectious disease

Keywords: endhothelial function anthocyanins arterial stiffness açaí juçara
deep learning signature for predicting occult nodal metastasis of clinical n0 lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: the purpose of this study is to evaluate the performance of a pet/ct-based deep learning signature for predicting occult nodal metastasis of clinical stage n0 non-small cell lung cancer in a multicenter prospective cohort.


Eligibility criteria:
inclusion criteria: (1) participants scheduled for surgery for radiological finding of pulmonary lesions from the preoperative thin-section ct scans; (2) the maximum short-axis diameter of n1 and n2 lymph nodes less than 1 cm on ct scan; (3) the suvmax of n1 and n2 lymph nodes less than 2.5; (4) pathological confirmation of primary nsclc; (5) age ranging from 20-75 years; (6) obtained written informed consent. exclusion criteria: (1) multiple lung lesions; (2) poor quality of pet-ct images; (3) participants with incomplete clinical information; (4) participants not receiving systematic lymph node dissection; (5) participants who have received neoadjuvant therapy.

Keywords: lung cancer lymph node metastasis deep learning pet-ct
impact of cannulation strategy on neurologic injury in infants with respiratory failure

Conditions: Respiratory Failure

Summary: there has been increasing use of venoarterial (va) extracorporeal membrane oxygenation (ecmo) for infants with respiratory failure, up to 92% of neonatal respiratory support in 2021. this study seeks to leverage the increased use of va ecmo in this cohort to enrich an evaluation of the differences in rate of intracranial hemorrhage and ischemic stroke between venovenous (vv) and va ecmo among infants with respiratory failure where clinicians may choose either strategy. this project is a retrospective review of data in the elso registry.

from 2019-2021, there was increased use of venoarterial (va) extracorporeal membrane oxygenation (ecmo) for infants with respiratory failure, up to 92% of neonatal respiratory support in 2021. the primary aim is to estimate the average effect on the rate of neurologic injury of va ecmo versus venovenous (vv) among infants with respiratory failure over the period 2013-2018, during which clinicians could choose either cannulation strategy. this causal effect will be estimated using an inverse propensity weighted (ipw) approach. secondarily, the investigators will project this estimated treatment effect forward into the period 2019-2021. the beginning of this period roughly corresponds to start of increased use of va ecmo. under the assumption of a homogenous treatment effect across both study periods, the rate of neurologic injury that would have occurred in 2019-2021 will be estimated, had the rate of va ecmo not increased relative to pre-2019 levels. the hypothesis is that the results will point to an increased rate of neurologic injury starting in 2019 due to the increased use of va ecmo.

Eligibility criteria:
inclusion criteria: * patient weighed less than or equal to 10kg at start of ecmo * pulmonary support was the indication for ecls * initial cannulation strategy was vv or va * the run occurred during the period 2013-2023 exclusion criteria: * patient had cdh * patient was post-cardiotomy * non-conventional initial cannulation strategies were employed, such as * central cannulation (surrogate for inability to achieve peripheral cannulation) * veno-veno-arterial ecmo * initial cannulation approach reported as "other" * patient was transported into or out of elso center on ecmo support * patient had pre-ecls cardiac arrest * patient did not have subsequent ecmo runs in the elso registry

Keywords: ecmo
observational study on a chinese population

Conditions: Metabolic Disease; Nutrition Disorders; Genetic Predisposition to Disease

Summary: an observational study was conducted in a health examination center to distinguish risk factors for health in a randomly recruited volunteers of chinese population.


Eligibility criteria:
inclusion criteria: * han population, living in shenzhen city for \> 2 y, not in pregnancy, without hepatic diseases and renal diseases exclusion criteria: * caught by organic diseases
functional improvement of progenitor cells and endothelial function by vildagliptin in diabetes mellitus (finnja-dm).

Conditions: SDF-1 is an Important Cytokine for Neovascularization. Cleavage of SDF-1 is Reduced by DPPIV Inhibitors

Summary: sdf-1, an important cytokine for neovascularisation is cleaved by (dipeptidyl peptidase iv) dppiv. the aim of this study is to assess the effect of the dipeptidyl peptidase iv inhibitor vildagliptin (galvus®) on endothelial function as well as number and functional activity of progenitor cells in patients with documented diabetes mellitus.

the peptidase cd26 (dppiv/dipeptidyl peptidase iv) removes dipeptides from the amino terminus of proteins and thereby inactivates these cleaved proteins. it was shown, that cd26 cleaves sdf-1 into a non-mitogenic molecule. inhibition or deletion of cd26 leads to an increased homing of hematopoietic progenitor cells to the bone marrow after transplantation by increasing the invasion capacity of these cells {campbell et al. 2008; christopherson et al. 2004}. the cytokine sdf-1 is released in response to hypoxia, is crucial for progenitor cell homing and recruitment of cells for neovascularisation. invasion capacity is closely related to the cytokine sdf-1 and the sdf-1 receptor cxcr4 {ceradini et al. 2004}. the in vivo neovascularisation capacity of progenitor cells is closely correlated to their functional capacity as sdf-1 induced invasion or colony-forming capacity {heeschen et al. 2004; britten et al. 2003; assmus et al. 2007}. therefore, the aim of this study is to assess the effect of the dipeptidyl peptidase iv inhibitor vildagliptin on endothelial function as well as number and functional activity of progenitor cells in patients with documented diabetes mellitus.

Eligibility criteria:
inclusion criteria: * patients with diabetes mellitus type 2 under stable medication * hba1c between 7% an 10% * age between 18 and 80 years * signed informed consent exclusion criteria: * atrial fibrillation (plethysmographic recordings can only obtained in sinus-rhythm) * cad with reduced left ventricular ejection fraction (lvef \<45%) * pregnancy, chronic or acute infection, fever * diabetes mellitus type 1 * newly diagnosed diabetes, uncontrolled diabetes * neoplasm * known allergy to study drug * severe liver/kidney disease * hiv, hepatitis * participation at other studies within the last 30 days

Keywords: cad diabetes sdf-1 endothelial function
effect of kangaroo care on phyiological weight loss in term newborns

Conditions: Infant, Newborn; Weight Loss

Summary: the aim of the study is to evaluate the effect of kangaroo care on physiological weight loss in term newborns.

the data collection process continues in a randomized controlled experimental study conducted to determine the effect of kangaroo care on physiological weight loss in term newborns. in the calculation made for the determined effect size, 80% power, 5% margin of error and one-way statistical significance, the experimental group was planned as 51 and the control group as 51 newborns. in this reporting period, 25 newborns as the experimental group and 30 newborns as the control group were followed up and interviewed with the mother. mothers who meet the criteria to participate in the research are informed about the research in the delivery room or in the first hours of delivery. the mothers of the experimental group who accept to participate in the research are given training on how to make kangaroo care and what to pay attention to. breastfeeding of the mother, the number and frequency of bottle feeding, kangaroo care, diuresis, defecation numbers and weight are recorded by following up. physiological weight losses are determined by comparing birth weight with daily weight losses. a cotton kangaroo care blanket is given to every mother who agrees to participate in the study, so that mothers can care for their kangaroos comfortably and to continue kangaroo care at home. these covers, prepared for kangaroo care, increase the motivation of mothers to participate in the study. in order to facilitate the follow-up of diuresis and defecation numbers, the family is supported in the evaluation of diapers (number, weight).

Eligibility criteria:
inclusion criteria: * term babies born between 37-42 weeks of gestation * newborns born vaginally * newborns with developed sucking and swallowing reflexes exclusion criteria: * newborns born with c-section * newborns in need of nicu care * preterm newborns (born \<37 weeks of gestation) * newborns in need of oxygen * genetic or metabolic disease (of the baby) limiting breastfeeding * hiv (+) mother * mother having a chronic disease that will affect breastfeeding * mother using drugs that pass into the breastmilk and affect the baby * presence of a medical problem that will prevent the mother and baby from staying together

Keywords: term newborn weight loss kangaroo care
reducing sedentary time in obese adults (study 2)

Conditions: Obesity

Summary: greater time spent in sedentary behaviors, independent of physical activity level, can increase risk of morbidity and mortality. objective assessments indicate that bariatric surgery patients spend large amounts of time in sedentary behaviors. the present study is the first to test whether a mobile health (mhealth) approach that employs widely adopted smartphone technology to monitor and modify sedentary behaviors as they occur is a feasible and acceptable method of reducing sedentary time in these patients and other obese populations.


Eligibility criteria:
inclusion criteria: * bariatric surgery patients and other obese individuals will be considered * body mass index \>= 25 kg/m2 exclusion criteria: * report being unable to engage in daily activities and walk continuously for \>= 10 minutes without assistance * are currently involved in a physical activity intervention. * are unable to read or understand the study materials * are currently taking medications that cause dizziness and/or feeling faint when sitting or standing. * report any condition that in the opinion of investigators would preclude adherence to the intervention protocol including plans to relocate, history of substance abuse or other significant psychiatric problems, or terminal illness.

Keywords: sedentary behavior physical activity obesity mobile health smartphone time spent sedentary
hallux valgus conservative treatment

Conditions: Hallux Valgus

Summary: studying the effect of kinesiotape on hallux valgus angle and pain in hallux valgus patients.

30 patients (male and female) suffering from bilateral halux valgus. divided randomly into 2 groups 1. st group receive kinesiotape bilaterally for correction : hallux valgus angle (hva) was measured using xray and pain was measured using vas before applying tape and after 8 weeks of tape application. 2. nd group receive placebo tape bilaterally and had the same measurements. 2 groups were on a group of exercises

Eligibility criteria:
inclusion criteria: * mobile hallux valgus exclusion criteria: * using orthotics * knee malalignment
effect of liver and blood-stage treatment on subsequent plasmodium reinfection and morbidity

Conditions: Plasmodium Vivax Infection; Plasmodium Vivax Clinical Episode; Plasmodium Falciparum Infection; Plasmodium Falciparum Clinical Episode

Summary: this study specifically seeks to quantify the contribution of relapes to the burden of p. vivax infections and disease by determining on the effect of radical pre-erythrocytic and erythrocytic clearance on subsequent rates of plasmodium spp. infection and disease in children aged 5-10 years in a treatment to re-infection study design. in order the clear liver-stage/blood-stages g6pd-normal children were randomised to receive chloroquine (3 days, standard dose) and coartem (3 days, standard dose) plus either i) primaquine (20 days, 0.5mg/kg) or ii) placebo (20days). these drugs were administered over a period of 4 weeks. in addition to this epidemiological data, the study will assess the natural acquisition of cellular and humoral immune responses to p. falciparum and p. vivax, thus assisting in the determination of correlates of clinical immunity to p. falciparum and p. vivax in png children aged 5-10 years. these data will not only be essential for development of future vaccines against p. vivax and p falciparum but provide invaluable insight into the contribution of long-lasting liver-stages to the force of infection with p. vivax that will contribute towards designing more rational approaches to the treatment of p. vivax both in the context of case management and future attempts at elimination.


Eligibility criteria:
inclusion criteria: * aged 5-10 years (±3 months) * permanent residents of the area * absence of history of hypersensitivity reactions to the drugs exclusion criteria: * chronic illness * severe malnutrition (weight-for-age nutritional z score \[waz\] \<60th percentile) * severe anemia (hb \<5 g/dl), * g-6-pd deficiency (\<60% g-6-pd activity) * permanent disability, which prevents or impedes study participation. any 1 or more of the criteria is sufficient to exclude study participation.

Keywords: plasmodium vivax hypnozoites primaquine liver-stage blood-stage plasmodium falciparum
massage on pain levels, range of motion, and muscle strength in unilateral lower limb amputees

Conditions: Amputation

Summary: the purpose of this graduate research study is to explore the therapeutic benefits of myofascial release massage on lower limb amputees with pain levels, range of motion, and muscle strength.

there are no other studies that address the effects of massage therapy as a treatment option for lower limb amputees suffering from lower back pain or the effects this has on muscle performance and/or range of motion. in addressing the physical, psychological, and social needs of a person living with limb loss, there should be a consideration for a multidisciplinary approach that could potentially include massage therapy as a fundamental standard of care. therefore, the purpose of this graduate student research study is to test whether myofascial release massage can improve lower back pain levels in lower limb amputees and consequently improve quality of life and other measurable variables such as range of motion and muscle strength.

Eligibility criteria:
inclusion criteria: * pain in the lower back region * trans-tibial, trans-femoral, knee disarticulation, or symes amputees * unilateral lower limb amputation * subject willing to receive massage once a week over a 4 week span * subject must be willing to abstain from over-the-counter and prescription pain medication 24 hours before each treatment exclusion criteria: * open wounds within the treatment area * bilateral lower limb amputees * pregnant subjects (self-reported) * lymphedema * amputation distal to ankle * subjects who currently receive regular massage treatments * subjects taking anticoagulant medication * subjects with allergies to coconut oil