Kornimate/medical-research-clean huggingface dataset:
study to compare pathologic type, nih and who criteria,and mechanism of gist malignant transformation

Conditions: Method of Differentiating Benignancy and Malignancy, Grading and Staging for GIST

Summary: evaluate the reliability of morphology standards for gist pathologic type, staging and grading by retrospective analyzing clinical data; on this basis, establish a gist standardized and individualized treatment mode to maximum benefit gist patients, avoid under- and over-treatment

1. retrospective analysis of gist cases in the recent five years: the gist clinical data of fudan university zhongshan hospital from 2007 january to 2012 december were collected. by reviewing the he slides, gist was evaluated by 12 indicators, nih scheme and who standard. accomplish the gene sequencing of kit, pdgfra, b-raf, and sdh. follow up the patients about their treatment and prognosis. analyze and compare the advantages and disadvantages of the histomorphology indicators, nih scheme, and who standard. 2. organize the first multicenter prospective cohort study of gist individualized treatment based on the histomorphology. obtain the evidence of histological assessment for gist by following up patients for 3 years. 3. establish an evaluation criteria based on the morphology of gist. make objective evaluations about gist tumor size, tumor location and gene mutation status in the prognosis estimate. make rules to effectively guide individualized treatment of gist.

Eligibility criteria:
inclusion criteria: * all patients pathologically diagnosed with gist during the period from 2017 to 2020 exclusion criteria: * only have biopsy diagnosis * only have liver metastasis or peritoneal dissemination * received imatinib treatment before surgery

Keywords: gist grading and staging
hydroxyurea and transfusion

Conditions: Sickle Cell Disease

Summary: this study will prospectively investigate the feasibility, safety, and transfusion requirements of adding hydroxyurea to simple chronic transfusions for patients with sickle cell anemia already on chronic transfusions.

this is a single-arm, prospective study of hydroxyurea added to simple chronic transfusions, combination treatment termed hydroxyurea and transfusion (hat). the primary objective of the study is to determine the feasibility of hat for patients with sickle cell anemia (sca) currently being treated only with simple transfusions for stroke prevention. secondary objectives include: to evaluate the safety of hat and to determine if hat decreases transfusion requirements in this patient population. exploratory objectives include: to evaluate with hat changes in pre-transfusion laboratories and biomarkers of cerebrovascular disease progression, and to describe changes on brain imaging.

Eligibility criteria:
inclusion criteria: 1. diagnosis of sca (hb ss or sβ0 thalassemia). 2. on simple chronic transfusion therapy for stroke prevention (primary or secondary prevention) for ≥1 year with no plans to stop simple chronic transfusion in the next year. exclusion criteria: 1. poor adherence to simple transfusion regimen as defined by having an hbs \>45% at any time in the last year and a transfusion interval \>5 weeks. 2. treatment with hydroxyurea in the 12 months prior to study enrollment. 3. abnormal initial laboratory values (temporary exclusions): 1. absolute neutrophil count \<1.5 x 10\^9/l 2. platelet count \<100 x 10\^9/l 3. serum creatinine more than twice upper limit for age 4. pregnancy or unwillingness to use a medically acceptable form of contraception if sexually active.

Keywords: hydroxyurea transfusion
effect of different fat enriched meats on the hepatic cholesterol synthesis

Conditions: Lipid Metabolism Disorders; Sterols; Diet, High-Fat; Cholesterol; Fatty Acids; Hyperlipidemias

Summary: the objective of the study is to assess the effect of two diets with different fat composition on cholesterol metabolism. the study was a randomized cross-over trial where volunteers follow two study periods with different types of meat (lean and fat red meat) separately by a ten days wash-out period. at the beginning of the study and after the study periods the following parameters are determined: anthropometric (weight, waist, circumference and body mass index), blood pressure, dietary (72-hours dietary registry) and exercise assessments and biochemical analysis (total cholesterol, triglycerides, hdl cholesterol, ldl cholesterol, apolipoprotein a1, apolipoprotein b, iron, transferring, ferritin, uric acid, glucose, hba1c and insulin). serum concentration of non cholesterol sterols (sitosterol, campesterol, stigmasterol, desmosterol and lanosterol) and oxysterols (24s-hydroxycholesterol, 27-hydroxycholesterol and 7α-hydroxycholestenone) were measured by high performance liquid chromatography tandem mass spectrometry in these subjects throughout along the study in order to demonstrate the effect of different red meat on the hepatic metabolism of cholesterol.


Eligibility criteria:
inclusion criteria: * normolipemic healthy subjects defined by levels of ldl cholesterol and triglycerides below the 90th percentile adjusted for age and sex. * diet and stable lifestyle with controllable feeding. exclusion criteria: * pregnancy or intention of pregnancy during the study. * lipid lowering drugs in the last 3 months.

Keywords: lipids non cholesterol sterols oxysterols cholesterol metabolism
implementation of physical cancer rehabilitation programmes in a european healthcare system.

Conditions: Cancer; Fatigue

Summary: the aim of this study is to develop and identify the most effective strategy to implement pcrps into daily care. we want to assess the added value of a multi-faceted strategy compared with a single-faceted patient-directed strategy.

the aim of this study is to develop and identify the most effective strategy to implement pcrps into daily care. we want to assess the added value of a multi-faceted strategy compared with a single-faceted patient-directed strategy. we will conduct a clustered controlled before and after study (cba) in the netherlands that compares two strategies to implement pcrps. the patient-directed (pd) strategy (five hospitals) will focus on change at the patient level. the multi-faceted (mf) strategy (five hospitals) will focus on change at the patient, professional and organizational levels. eligibility criteria are as follows: (a) patients: adults; preferably (history of) cancer in the gastro-intestinal, reproductive and/or urological system; successful primary treatment; and without recurrence/metastases. (b) healthcare professionals: involved in cancer care. a stepwise approach will be followed: step 1: analysis of the current implementation of pcrps and the examination of barriers and facilitators for implementation, via a qualitative study with patients (four focus groups n = 10-12) and their healthcare workers (four focus groups n = 10-12 and individual interviews n = 30-40) and collecting data on adherence to quality indicators (n = 500 patients, 50 per hospital). step 2: selection and development of interventions to create a pd and mf strategy during expert's roundtable discussions, using the knowledge gained in step 1 and a literature search of the effect of strategies for implementing pcrps. step 3: test and compare both strategies with a clustered cba (effectiveness, process evaluation and costs), by data extraction from existing registration systems, questionnaires and interviews. for the effectiveness and cost-effectiveness, n = 500 patients, 50 per hospital. for the process evaluation, n=50 patients, 5 per hospital, and n = 40 healthcare professionals, 4 per hospital.

Eligibility criteria:
inclusion criteria: patients: * preferably (history of) cancer in the gastro-intestinal, reproductive and/or urological system; successful primary treatment; and without recurrence/metastases. * adults * diagnosed in one of the participating hospitals * able to read and understand dutch healthcare professionals: • involved in cancer care in one of the participating hospitals

Keywords: oncology service hospital patient-centred exercise neoplasms rehabilitation qualitative research health plan implementation quality of health care guidelines quality of life
community health advocates for motivating pap use in our neighborhoods.

Conditions: Obstructive Sleep Apnea

Summary: the purpose of this research is to compare the impact of motivational enhancement therapy (met), delivered by culturally congruent community health care workers (chws) versus usual care patients with previously untreated moderate-to-severe obstructive sleep apnea (osa) on adherence to positive airway pressure (pap) therapy.


Eligibility criteria:
inclusion criteria * ≥ 18 years of age * moderate-to-severe osa * available to attend study visits and sessions * reliable access to a phone exclusion criteria * prior or current use of pap therapy or other treatment (e.g., oral appliance) for osa * history of upper airway surgery for osa * moderate to severe insomnia * commercial drivers * use of non-standard pap including adaptive servo-ventilation or bi-level positive airway pressure * report of motor vehicle accident or near-miss due to sleepiness within the 2 previous years * unstable medical conditions that may preclude enrollment in the protocol such as: uncontrolled angina and/or congestive heart failure, uncontrolled blood pressure or resistant hypertension, severe chronic obstructive pulmonary disease, cancer, and active psychiatric disease (e.g., major depression) * other sleep disorders (e.g., circadian rhythm disorder) * use of supplemental oxygen during wakefulness or sleep * central sleep apnea, obesity hypoventilation syndrome or cheyne-stokes respiration based on the home sleep apnea test * resting awake oxygen saturation (spo2) \< 90% * participation in another clinical trial
renal denervation for complicated hypertension

Conditions: Hypertension

Summary: this is an observational proof of concept study investigating the safety and effectiveness of renal denervation to lower blood pressure in people whose blood pressure is not adequately controlled due to: * intolerance to antihypertensive medication * inability to take antihypertensive medication due to planned pregnancy * renal artery stenosis * chronic kidney disease * non-compliance to antihypertensive medication a total of 125 participants, 25 from each of the groups mentioned above will be recruited to the study. the duration of this study is 36 months.


Eligibility criteria:
inclusion criteria: * bp ≥140/90 mmhg (or ≥130/80 mmhg for patients with diabetes) * intolerance to ≥2 antihypertensive drug classes * inability to take angiotensin-converting-enzyme inhibitor (acei), angiotensin ii receptor blockers (arbs) or direct renin inhibitors (dris) due to planned pregnancy * renal artery stenosis * chronic kidney disease exclusion criteria: * renal artery anatomy ineligible for treatment * individual has had myocardial infarction, unstable angina or cerebrovascular accident within 6 months of screening visit * female participants of childbearing potential must have negative pregnancy test prior to treatment

Keywords: renal denervation blood pressure cardiovascular risk target organ damage sympathetic activity chronic kidney disease non-compliance
the effect of hot cataplasm with caraway oil in the treatment of irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: the purpose of this study is to determine whether a daily use of a kneipp hot cataplasm with caraway oil is effective in the treatment of abdominal pain and complaints caused by irritable bowel syndrome.

see above.

Eligibility criteria:
inclusion criteria: * irritable bowel syndrome according to rom-iii * subtype diarrhea or alternating * discomfort or pain \> 1 times a week * discomfort or pain \> 4 on a visual analog scale exclusion criteria: * inflammatory bowel diseases (test results necessary) * lactose, fructose malabsorption (test results necessary) * celiac disease * pregnancy or breastfeeding * colectomy or hemicolectomy \>50cm * severe metabolic disorders, hormonal disorders, cardiac or respiratory failure, liver or renal diseases * severe depression, psychotic or psychiatric disorders, substance abuse * cancer within the last 5 years * allergy to caraway * acute inflammatory diseases
pupillometry and locus coeruleus activation (pulca)

Conditions: Visual Impairment; Ocular Illness

Summary: this project will apply non-invasive, trans-cutaneous vagal nerve stimulation using various stimulation parameters to young, healthy adults to find the optimal set of parameters to elicit pupil response.


Eligibility criteria:
inclusion criteria: * fluent english speaker with reading and writing proficiency. exclusion criteria: * participants with significant visual impairment or ocular illness may be excluded at the discretion of the principal investigator. * major medical illnesses including severe neurological illness (e.g. stroke, seizure history), autoimmune disorders, and severe psychiatric diseases (e.g., schizophrenia) * any history of brain surgery, tumor, intracranial metal implantation, pacemakers, or other implanted devices. * current (i.e. within 48 hours of the session) prescription medication or over-the-counter medication use. * illicit alcohol or drug use. caffeine (e.g, coffee, energy drinks) consumption prior to the visit.
gallant 8 tesaglitazar add-on to metformin

Conditions: Type 2 Diabetes

Summary: this is a 24-week randomized double-blind, parallel-group, multi-center, placebo-controlled study of tesaglitazar (0.5 mg and 1 mg) given as add-on therapy to metformin in patients with type 2 diabetes, not adequately controlled on optimized metformin treatment and on diet/lifestyle advice during the titration and run-in period. the study comprises a 2-week enrollment period, 6 week placebo metformin titration period, 2-week single-blind run-in period, followed by a 24-week double blind treatment period and a 3-week follow-up period


Eligibility criteria:
inclusion criteria: * provision of a written informed consent * men or women who are \>=18 years of age * female patients: postmenopausal, hysterectomized, or if of childbearing potential, using a reliable method of birth control * diagnosed with type 2 diabetes * treated with diet alone or treatment with a single oral antidiabetic agent or low doses of two oral antidiabetic agents exclusion criteria: * type 1 diabetes * new york heart association heart failure class iii or iv * treatment with chronic insulin * history of hypersensitivity or intolerance to any peroxisome proliferator-activated receptor agonist (like actos or avandia), fenofibrate, metformin or 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor (statin) * history of drug-induced myopathy or drug-induced creatine kinase elevation, liver enzyme elevations, neutropenia (low white blood cells) * creatinine levels above twice the normal range * creatine kinase above 3 times the upper limit of normal * received any investigational product in other clinical studies within 12 weeks * any clinically significant abnormality identified on physical examination, laboratory tests or electrocardiogram, which in the judgment of the investigator would compromise the patient's safety or successful participation in the clinical study
effect of pci on clinical prognosis of chronic coronary artery occlusion

Conditions: Coronary Atheroscleroses

Summary: coronary chronic total occlusions (ctos) are considered to increase the risk of adverse clinical outcomes. the purpose of this study was to evaluate whether long-term clinical outcomes could be improved by successful percutaneous coronary intervention (pci) over optimal medical therapy (omt) in cto patients.

patients with cto lesions undergoing pci at the first affiliated hospital of nanjing medical university from january 2011 to december 2017 were enrolled. after someone were excluded due to cabg surgery, patients who met the enrollment criteria were divided into successful cto-pci group and cto-omt group based on the treatment received. the study primary endpoint was major adverse cardiac cerebrovascular events (macce), including cardiac death, recurrent myocardial infarction, unplanned revascularization, and stroke. the secondary endpoint was all-cause death.

Eligibility criteria:
inclusion criteria: * patients with at least one coronary cto lesion at our hospital in between january 2011 and december 2017 exclusion criteria: * (1) patients with st-segment elevation myocardial infarction (stemi) * (2)a history of coronary artery bypass grafting (cabg) * (3) cardiogenic shock * (4) malignant tumor. patients were referred for pci based on cto-related symptoms or evidence of viability, or corresponding ischemia in the area of the cto artery.

Keywords: chronic total occlusion percutaneous coronary intervention major adverse cardiovascular events
reproducibility of the functional movement screen test

Conditions: Locomotor Pain Disorder

Summary: the main objective of the study is to determine the inter-evaluator and intra-evaluator reproducibility of the fms test as an evaluation tool in amateur rugby players. the secondary objective of the study is to evaluate the abilities of the fms test as a predictive tool for detecting possible injuries during a sports season in amateur rugby players.

rugby is a very popular sport in france, since it has more than 300,000 dismissed. the 2023 world cup will take place in france, and in view of the enthusiasm that is created around the "xv de france" team, there will be a great number of new players. yet there are many injuries in this sport, despite the adaptations of the french rugby federation. the injuries of these amateur players will handicap their performance within their club (an injured player will be injured more easily in the future) and have a impact on their personal and professional life. with this in mind, it would be desirable to have a predictive tool for possible wounds. for this, agullo et al. had in the previous study "reproducibility of the functional movement screen (fms) test in the amateur rugby player" (id-rcb: 2018-a03490-55) selected this tool already evaluated in the context of prediction injuries in other sports (hockey or american football). the fms offers an overall assessment of the subject, based on seven so-called movements fundamentals, combining mobility and stability, making it possible to assess the deficiencies of the individual; a prevention plan will then be adapted to the subject.

Eligibility criteria:
inclusion criteria: * rugby players in the "amateur" and "senior" categories * must be able to play a match within a week of the fms test evaluation. exclusion criteria: * players evolving or having evolved beyond the "federal 3" division for men or "federal 1" for women * pregnant and breastfeeding women * people in an emergency situation * people unable to give their consent (including people under guardianship) * patients already involved in another study.

Keywords: fms, rugby
alpha-galactosidase enzyme and irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: the purpose of this study is to determine whether alpha-galactosidase enzyme is affective in alleviating the symptoms of irritable bowel syndrome (ibs).


Eligibility criteria:
inclusion criteria: * clinical diagnosis of ibs according to rome iii criteria, additionally abdominal distension or flatulence the most disturbing symptom * age 18-65 years * colonoscopy conducted within the previous 5 years, finding macroscopically and histologically normal exclusion criteria: * organic gi disease. treated (min. 1 year) coeliac disease patients, and subjects with known and treated lactose intolerance are allowed to participate * malignancy * significant gastrointestinal surgery * clinically significant aberrancies in the screening-phase laboratory analyses * changes in regular medication during the previous 4 weeks * pregnancy or breast feeding * other disease or state that based on the investigator's evaluation complicates the conduction of the intervention, i.e. alcoholism, dementia * hereditary galactosemia
effectiveness of mirror therapy in stroke patients with unilateral neglect - a randomized controlled trial

Conditions: Hemispatial Neglect

Summary: hemi spatial neglect, or the tendency to ignore stimuli originating in a portion of the environment contra lateral to a cerebral lesion, can be a major source of functional handicap after stroke. the currently available treatments for unilateral neglect are scanning training, visual cuing approaches, limb activation strategies, visual imagery, tactile stimulation, prisms and sustained attention training.mirror therapy improves the hand function in sub-acute stroke. hypothesis: to evaluate the effectiveness of mirror therapy in the management of stroke patients with unilateral neglect.

about 30 - 50% of stroke patients are left with considerable residual deficits. the post stroke disabilities are due to loss of locomotion and activities of daily living, cognition and communication skills.hemispatial neglect has been reported in association with damage to several different cerebral structures in a large-scale distributed neurocognitive network.mirror therapy improves the hand function in sub-acute stroke. it also helps in the recovery of neglect in stroke patients. but little consensus exists as to whether one treatment is more efficacious than others and many studies fail to document duration of treatment effects or generalization to daily activities. the aim of our study is to evaluate the effectiveness of limb activation with mt and limb activation strategy alone in the management of stroke patients with unilateral neglect and to make the patient functional in activities of daily living.

Eligibility criteria:
inclusion criteria: 1.all stroke patients with parietal lobe and thalamic lesions 2. stroke duration: within 48 hours 3. patients willing to participate in the study 4. mri/ ct scan showing parietal lobe and thalamic lesion 5. patients with upper limb weakness exclusion criteria: 1. stroke duration more than 1 yr 2. glasgow coma scale (gcs) of less than 7 3. uncooperative patients

Keywords: hemispatial neglect, stroke
nanoparticle for dsa removal

Conditions: Kidney Failure; Presence of Donor Specific Antibodies

Summary: magnetic nanoparticles, coated with human leukocyte antigens (hla) to capture anti-hla antibodies with donor specificity (donor-specific antibodies, dsa), will be tested ex-vivo.

this project aims at developing a new method using human leukocyte antigens (hla)-coated magnetic nanoparticles to remove donor-specific antibodies (dsa) from the patients' blood ex vivo, while trying to keep the blood unaffected after exposure to the particles. nanoparticles will be engineered and tested ex vivo. while nanoparticles were successfully coated with macromolecules such as antibodies in the past, this is a new approach, which will be performed by the research group. the goal of this project is to capture dsa in patient blood ex vivo and to remove them by magnetic separation. efficacy and safety of this procedure will be assessed, especially the interaction of these novel particles with other blood components such as coagulation factors or effector cells, which could produce inflammatory mediators. according analyses are initiated and carried out.

Eligibility criteria:
inclusion criteria: * dsa in the blood as detected by luminex® * adults (\>18 years old) * informed written consent exclusion criteria: * inability to follow the procedures of the study, due to language problems, psychological disorders, social conditions or dementia * pregnancy and/or breast feeding * unwillingness to participate in this study

Keywords: donor specific antibodies kidney transplantation coated nanoparticles