collection of clinical and instrumental data in adult subjects suffering from atopic dermatitis

Conditions: Atopic Dermatitis

Summary: atopic dermatitis represents a real challenge in public health as it affects a large percentage of children and adults. affected individuals must cope with a significant psychosocial burden, in addition to dealing with the medical aspects of the disease. the purpose of this exploratory study is to collect clinical severity ad data, using po-scorad (self-assessment by the subjects), scorad evolution, instrumental measurements and treatment follow up of subjects. the future objective is to develop a personalised prediction model of ad flares in order to improve management of ad by more accurate severity evaluations by the subject and the physician. development of a method of early detection of flares will open new treatment pathways for ad management.

this study will be conducted as a french monocentric exploratory study in adults with mild to moderate atopic dermatitis, and will be conducted on a maximum 25 included subjects. the clinical study will include 4 study visits, after inclusion visit, and the maximum duration of the study for each subject will be 3 months : day 1, day 29, day 57, day 85. in case of ad flare suspicion, the investigator may recommend a complementary visit. any complementary visit will be confirmed by investigator according to the subject's information: photographs and po-scorad sent by the subject. if visit is confirmed, it will be scheduled as soon as possible. the objectives are: * to collect clinical ad severity data in order to evaluate natural ad evolution with clinical and subject's scales, during a three-month period. * to collect non-invasive instrumental ad data on a target area and on adjacent area: cutaneous hydration, epidermal barrier conditions and colorimetric parameters on cutaneous erythema * to examine clinical and instrumental ad data * to collect illustrative photographs of ad lesions

Eligibility criteria:
only most important inclusion and exclusion criteria are listed : those which are study specific. inclusion criteria: * subject suffering from atopic dermatitis according to the u.k. working party's diagnostic criteria for atopic dermatitis (3). * subject with mild to moderate atopic dermatitis with 20 \<= scorad \<= 40 at inclusion * subject with flare frequency ≥ 4 over the last year * subject with a cutaneous target area, allowing the measurements, located on upper or lower limbs and defined as a usual ad flare area according to the subject * subject owning a smartphone suitable with the 5.0 downloaded version of po-scorad® app * subject who agrees to use daily a free mobile app: po-scorad® exclusion criteria: * subject having received artificial uv exposure or excessive exposure to natural sunlight within the 2 weeks before the inclusion visit or planning to be exposed to excessive or prolonged natural sunlight or uv exposures for the duration of the study * subject with a hirsute target area * systemic immunosuppressive therapy (excepted systemic corticoids) within 3 months before the inclusion visit or ongoing at inclusion visit. * systemic corticoids taken (whatever the number of intake) within 4 weeks before the inclusion visit or ongoing at inclusion visit. * phototherapy performed within 4 weeks before the inclusion visit or ongoing at inclusion visit * systemic antibiotics taken within 7 days before the inclusion visit or ongoing at inclusion visit. * moderate to high-potency topical corticosteroids applied within 7 days on upper or lower limbs before the inclusion visit or ongoing at inclusion visit * topical immunomodulators (tims), applied within 7 days on upper or lower limbs before the inclusion visit or ongoing at inclusion visit * any topical treatment or product applied between the evening before the inclusion visit and the inclusion visit * water applied on target area within 4 hours before the inclusion visit