Kornimate/medical-research-clean huggingface dataset:
clinical outcomes after implementation of continuous vital sign monitoring on the general ward.

Conditions: Clinical Deterioration

Summary: in 2018, continuous monitoring (cm) of 5 vital signs with a wearable device, including automated mews calculation within the emr were introduced on the surgical and internal medicine ward of our hospital. rather than taking the measurements manually, this enabled the nurses to periodically validate the continuously derived vital signs at the protocolled moments, and simultaneously get an automatically calculated mews reading,. moreover, continuous vital sign monitoring provides single channel alarms and trends of the vital signs in between the regular measurement moments. compared to periodic manual measurements and registration in the emr, the continuous vital sign monitoring and automated mews calculations in the emr may result in better identification of clinical deterioration, and may improve clinical outcome. the primary objective of this study is to evaluate changes in total hospital and ward stay, "total events" during admission (rapid response team (rrt) calls and unexpected intensive care unit (uicu) admissions and deaths) after implementation of cm on the regular surgical and internal medicine wards. secondary objective is to evaluate changes in mews scores at the moment of the uicu admissions, length of hospital, ward and icu stay and the proportion of rrt calls that results in a icu admission.


Eligibility criteria:
inclusion criteria: * admission on inclusion ward. exclusion criteria: * opt out of file study

Keywords: early warning scores continuous vital sign monitoring escalation of care icu-transfer deterioration prevention
underlying causes and related factors, and rehabilitation approaches

Conditions: Multiple Sclerosis

Summary: this study will be a cross-sectional observational study, followed by a pilot intervention. the aim of the study is to examine the underlying causes of walking-related performance fatigability, together with other related and influencing factors, to make up a clinical profile of patients with ms showing walking-related performance fatigability. in the second part of the study a pilot intervention will be executed to see if the investigators can improve the clinical status of the ms patients with walking-related performance fatigability.


Eligibility criteria:
inclusion criteria: * age between 18 and 70 years. * ms diagnosis according to mcdonald criteria. * capable of walking 6 minutes (independent or with unilateral support) without stopping. exclusion criteria: * exacerbation or relapse within last 3 months before study * other medical condition interfering with walking ability (e.g. cardiac or respiratory diseases, arthritis and fibromyalgia, stroke, parkinson).
use of glubran 2 ® in axillary lymphadenectomy without drain

Conditions: Seroma Following Procedure

Summary: axillary lymphadenectomy in breast cancer continues to be a common practice in certain patients. the use of sealants and drains continues to be a source of disagreement among the scientific community. that is why the study was designed to show whether the sealant reduces seroma after axillary lymphadenectomy without drainage.

a study has been designed to assess whether the sealant reduces the rate of symptomatic seroma measured by the number of evacuating punctures. likewise, the decrease in volume due to the seroma between the two groups and the quality of life of the patients is assessed, given that none of them has a drain

Eligibility criteria:
inclusion criteria: * over 18 years old * conservative surgery for breast cancer with associated axillary lymphadenectomy exclusion criteria: * mastectomy * history of axillary surgery or ipsilateral axillary radiotherapy * asa 4 patients. (asa 3 patients selected) * lack of adequate cognitive capacity and/or signed informed consent * pregnancy
lstr in chevron osteotomy

Conditions: Bunion

Summary: the goal of this clinical trial is to determine if performing a lateral soft tissue release during a chevron osteotomy (or akin osteotomy when appropriate) for bunions leads to better correction without added complications in 200 patients over the age of 18 years old with the capacity to consent and mild to moderate bunions that are determined to benefit from chevron osteotomies by one of the irb approved study physicians. the main questions it aims to answer are: how does the addition of a lateral soft tissue release (lstr) in a chevron osteotomy bunion surgery affect hallux valgus alpha angle (hva) correction? how does the addition of an lstr in a chevron osteotomy bunion surgery affect intermetatarsal angle (ima) degrees of correction? researchers will compare chevron osteotomy bunion surgeries with and without lstr to see if lstrs lead to better correction without added complications. participants will: * be randomized to a control group where they receive a typical chevron osteotomy bunion surgery or to the experimental group where they receive a chevron osteotomy bunion surgery with an lstr. * complete surveys preoperatively and at 3, 6, and 12 months after surgery. * receive routine x-rays pre and postoperatively to compare hallux valgus angle (hva).


Eligibility criteria:
inclusion criteria: * over the age of 18 years old * have mild to moderate bunions that are determined to benefit from chevron osteotomies exclusion criteria: * under the age of 18 * connective tissue disease * juvenile bunions * severe bunions * revision surgery
can passive leg raise prevent spinal anesthesia-induced hypotension during cesarean section?

Conditions: Hypotension

Summary: all over the world, spinal anesthesia is widely used in cesarean sections due to its superiority over general anesthesia. due to reasons such as increased sensitivity to local anesthetics and increased intra-abdominal pressure in pregnant women, the frequency of hypotension increases by up to 70%. as a result of the blockage of sympathetic vasoconstrictor fibers originating from t1-l2 segments, loss of peripheral resistance, venous ponding occurs, and cardiac output decreases. also, the level required for cesarean operation is t4 or t5, and the possibility of affecting the cardiac accelerator fibers, so bradycardia due to the increase in parasympathetic activity may deepen the hypotension. if postspinal hypotension is not managed correctly, it may lead to maternal and fetal complications. in addition to classical methods such as fluid loading and prophylactic vasoconstrictor application to prevent hypotension in pregnant women after spinal anesthesia, techniques such as wrapping the lower extremity, lifting, or applying both together have been in question. passive leg raise application is an easy method that allows the blood collected in the lower part of the body to participate in the central circulation with the effect of gravity. an increase in venous return occurs with the passage of blood from the lower extremities to the thorax. thus, it leads to an increase in stroke volume and an increase in cardiac output. in this study, we aimed to determine the effectiveness of passive leg raising in preventing or reducing the depth of hypotension after spinal anesthesia in pregnant women who underwent cesarean section under spinal anesthesia.


Eligibility criteria:
inclusion criteria: * parturients who are planned for the elective cesarean section exclusion criteria: * failed spinal block * shift to general anesthesia * severe cardiac disease * hypertensive disorders of pregnancy

Keywords: cesarean section hypotension spinal anesthesia passive leg raise
effectiveness of early detection of atrial fibrillation

Conditions: Atrial Fibrillation

Summary: to verify if the screening opportunistic of atrial fibrillation (af) by means of the measurement of the arterial peripheral pulse is more effective than the habitual practice for the early detection of af in 65-year-old who come to primary care


Eligibility criteria:
inclusion criteria: * patients that come to his center of health for any motive. * that give his assent informed to take part in the study. exclusion criteria: * fa previous diagnosis

Keywords: atrial fibrillation screening prevention case finding primary care
a.i and machine learning based risk prediction model to improve the clinical management of endometrial cancer.

Conditions: Endometrium Cancer

Summary: prediction of preoperative endometrial biopsy: the evolution from hyperplasia to cancer, the prognosis and the risk of recurrence. intelligence methods artificial risk will be used to redefine the current risk classes including our profile immuno-mutational to provide a more precise characterization and closer to the real prognosis of the patient.

identify new risk factors for endometrial cancer, using an integrated multi-omics approach linked to a specific immune pattern (called momimic score) useful for improving oncology and surgery precision. the aim is to evaluate the predictive value of the momimic score for early identification of progression from precancerous lesions to endometrial carcinoma, prognosis and relapses, to help the clinician in the decision to treatments. through the identification during hysteroscopy of the most appropriate site for biopsies targeted endometrials, through an artificial intelligence algorithm applied to the video system hysteroscopic which, by comparing the information from the omics approach and the hysteroscopic image combined with radiogenomic information, it could help the gynecologist in the procedure and provide information on the prognosis through the omics-iconographic profile in order to calculate a preoperative predictive score. furthermore by modulating the surgical radicality, according to the information obtained, there will be a tendency to preserve fertility in young patients with a low-risk profile (since currently the risk factors are not sufficient to discriminate for a non-treatment radical). this will help the surgeon through an artificial intelligence algorithm applied to the system robotic/laparoscopic video, will guide the operator in decision-making procedures regarding the resection margins tumor, metastasis localization, pathological lymph node detection, and imaging driven by biomolecular information.

Eligibility criteria:
inclusion criteria: * age \> 18 years; * histological diagnosis of endometrial hyperplasia, endometrioid adenocarcinoma of the endometrium, healthy endometrium in patients undergoing total hysterectomy for benign extra-endometrial disease; * written informed consent (to the study and data processing), for the party's patients only prospective and/or in follow-up) for the retrospective cohort: availability of samples adequately stored at the biobank of the institute and availability of data relating to follow-up (at least 2 years) exclusion criteria: all exclusion criteria adopted in the surgical protocols will be applied to the study. in particular: * comorbidities not controlled with adequate medical therapy; * infections of the endometrial cavity (pyometra); * synchronous cancer; * neoadjuvant treatments; * previous radiotherapy treatments of the pelvic region; * hormone therapies.

Keywords: multiomics immune-iconographic pattern
the effect of acupressure on patients receiving brachytherapy

Conditions: Brachytherapy; Complementary Approaches; Gynecological Cancers

Summary: this study aimed to use acupressure to reduce anxiety in gynecologic cancer patients receiving brachytherapy. it was also aimed to investigate the effects of acupressure on anxiety, pain, and vital signs.

brachytherapy is a type of radiotherapy used in cancer treatment. in this method, the radiation source is placed directly on the tumor or the area to be treated. in this way, high doses of radiation are applied only to the target area, while surrounding healthy tissues are less damaged. brachytherapy is usually used in the treatment of certain types of cancer, such as prostate, cervix, breast, and skin cancer. gynecological brachytherapy is the application of brachytherapy in the treatment of gynecological cancers. it can be used especially in cancers of the uterus, cervix, vagina, and vulva. this treatment method is performed by placing the radiation source in the area where the tumor is located. brachytherapy can be used in combination with surgery, chemotherapy, or other types of radiotherapy in the treatment of these types of cancers. factors such as cancer burden, the problem of achieving remission, and the need for patients to remain immobile during the procedure, which is performed in a room that needs to be isolated due to radiation, contribute to symptoms such as pain and anxiety before and during treatment. these symptoms can sometimes affect vital signs. the need for patients to remain immobile during brachytherapy, the need to be isolated in a room due to radiation, and the discomfort caused by the applicators also increase anxiety in women. patients often experience fear and anxiety because there is insufficient information about brachytherapy that could help relieve their pain and anxiety. despite the complexity of such a procedure and the significant patient population, there are few studies on women's experiences with brachytherapy.

Eligibility criteria:
inclusion criteria: * being registered in selçuk university faculty of medicine hospital radiation oncology polyclinic * brachytherapy (intracavital brachytherapy) treatment protocol will be applied due to gynecological cancer. to be * karnofsky performance scale being 80 and above (performance scale for cancer patients) * being between the ages of 18 and 65 * being conscious and cooperative * verbal and written approval to participate in the study after an explanation about the study is made. exclusion criteria: impaired skin integrity in the acupressure application area * refuses to participate in the study after making a statement about the study. * bone or spine metastasis * amputation of the extremities to be applied * not having any mental illness

Keywords: brachytherapy acupressure nursing intervention
pilot study on withdrawal of spironolactone among heart failure with improved ejection fraction

Conditions: Heart Failure

Summary: the study is a randomized controlled pilot trial to evaluate whether withdrawal of spironolactone is safe and associated with re-deterioration of left ventricular function in patients with heart failure with improved ejection fraction. the aim of current trial is to test the hypothesis that withdrawal of spironolactone would not be associated with relapse of significant clinical deterioration of left ventricular systolic function.


Eligibility criteria:
inclusion criteria: * willing and capable of providing informed consent and agrees to follow the study protocol and schedule of clinical follow-up * age between 19 and 80 years old * prior diagnosis of heart failure with reduced left ventricular ejection fraction (lv ef ≤ 35%) and on medical therapy including spironolactone combined with angiotensin-converting enzyme or angiotensin receptor blocker or antiotensin receptior neprilysin blocker, beta-blocker. * lv ef ≥ 50% documented with echocardiography performed within a month * documented result of bnp or nt-probnp level within a month exclusion criteria: * dyspnea ≥ new york heart association (nyha) functional class iii * patients who need to discontinue spironolactone owing to prior adverse event * primary valvular heart disease with at least moderate degree * estimated glomerular filtration rate less than 30 ml/min per 1.73 m2 * uncontrolled hypertension defined as blood pressure more than 140/90 mmhg * presence of other clinical reason to continue spironolactone such as myocardial infarction, primary aldosteronism, and liver cirrhosis * hyperkalemia defined as serum potassium level less than 3.5 mmol per liter * pregnant and/or lactating women * life expectancy less than a year * patients who are not suitable to enrollment by investigator's discretion
the effects of a ficus carica in subjects with functional constipation

Conditions: Functional Constipation

Summary: the investigators performed a 8-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of fig paste on functional constipation. the investigators measured colon transit time, frequency of defecation, defecation time, stool type, and abdominal discomfort.


Eligibility criteria:
inclusion criteria: * age between 19 and 39 years, * diagnosis of functional constipation by rome iii criteria, * colon transit time (ctt) ≥ 36 h, * subjects giving written informed consent exclusion criteria: * allergic or hypersensitive response to any of the ingredients in the test products, * having previous history or current disease of digestive system, cardiovascular system, endocrine system and neurological disorder, * diagnosis of irritable bowel syndrome by rome iii criteria, etc,.
acquired von willebrand syndrome in severe aortic stenosis

Conditions: Bleeding; Von Willebrand Disease; Aortic Stenosis

Summary: patients with severe aortic stenosis often suffer from an acquired von willebrand syndrome by degeneration of the polymers during passage through the narrow valve leading to turbulences. we hypothesized that the diagnosis of acquired von willebrand syndrome influence perioperative blood loss in patients undergoing open cardiac valve replacement.

patients with severe aortic stenosis often suffer from an acquired von willebrand syndrome by degeneration of the polymers during passage through the narrow valve leading to turbulences. after written consent and an extended anamnesis of existing coagulopathy, we take three blood samples in these patients: before surgery, on the day after surgery and 4 weeks after surgery. we determine von willebrand factor in lab and by a point-of-care platelet function analyzer (multiplate tm). we measure amount of mediastinal drainage after 24 hours and blood product consumption in these patients.

Eligibility criteria:
inclusion criteria: * severe aortic stenosis (orifice area \< 1 cm2) exclusion criteria: * missing consent * severe hepatic or renal disfunction

Keywords: aortic stenosis aortic valve replacement von willebrand disease blood loss
phase ii dose titration study in patients with neuropathic pain

Conditions: Neuropathic Pain

Summary: the purpose of this study is to examine the effects of various increasing doses of ralfinamide in patients with neuropathic pain.


Eligibility criteria:
inclusion criteria: * male or female patients * females post-menopausal for at least 12 months, 24 months in india, poland, and austria * diagnosed by neurologist with current neuropathic pain exclusion criteria: * see inclusion criteria
atomoxetine for ats and opioid dependence during buprenorphine maintenance treatment in malaysia

Conditions: Opiate Dependence; Stimulant Dependence

Summary: to evaluate the tolerability, acceptability and potential effect size of the efficacy of 4 months of atomoxetine treatment for patients with co-occurring ats and heroin dependence (coats) receiving buprenorphine maintenance treatment (bmt) and educational drug and hiv risk reduction counseling (edrc).

the specific aims of the proposed study are: 1. to evaluate the tolerability, acceptability and potential effect size of the efficacy of 4 months of atomoxetine treatment for patients with co-occurring ats and heroin dependence (coats) receiving buprenorphine maintenance treatment (bmt) and educational drug and hiv risk reduction counseling (edrc). 2. to better characterize patients with co-occurring ats and heroin dependence (with regard to disturbances of mood, impulse control, executive functioning and patterns of drug use during mmt) and to evaluate the effects of atomoxetine on mood, impulsivity, and executive functioning (including attention, concentration, memory, and decision-making characteristics). 3. to provide training in drug abuse treatment, hiv prevention and treatment, and drug abuse clinical research to drug abuse clinical researchers and clinicians in kota bharu, malaysia.

Eligibility criteria:
inclusion criteria: * meet opioid and amphetamine-type stimulant (ats)dependence, as assessed by the structured clinical interview for diagnostic and statistical manual (dsm-iv) (scid) and documented by opioid-positive and ats positive urine tests. * report at least 2 or more days per week of ats use over the past month. exclusion criteria: * hypersensitivity to atomoxetine; * current use of a monoamine oxidase inhibitor (maoi) or use within the preceding 2 weeks; * suffer from narrow angle glaucoma; pheochromocytoma; severe cardiovascular disorder; liver enzymes greater than 3 times the upper limit of normal; liver failure or acute hepatitis; * pregnancy or breast feeding; * current suicide or homicide risk; * current psychotic disorder or major depression; * inability to understand the protocol or assessment questions. * a physician reviews the results of all baseline assessments and laboratory and other medical tests (cbc, chemistries, liver enzymes, hiv and hepatitis b and c, ekg, chest x-ray), takes a medical history, and performs a physical examination in order to confirm the patient's eligibility for the study.

Keywords: opiates ats hiv risks
social-heroes: health and education on research opportunities empower students and tackle inequalities

Conditions: Overweight; Obesity

Summary: social-heroes (social health and education research opportunities: empower students and tackle inequities) is a cluster-randomised study that aims to improve the health of vulnerable preschool children (3 to 6 years old) attending portuguese teip\* schools. ten preschools (about 478 children) will be randomly assigned to one of two groups. five preschools (≈ 239 children) will continue with their usual educational activities (control group). the other five preschools (≈ 239 children) will take part in a six-month "social-heroes" programme (intervention group). the intervention is created in participatory innovation labs where children, educators, families, community members and policy-makers design activities together, guided by a systems-thinking approach. these activities encourage healthier eating, more balanced 24-hour movement (active play, less sitting, better sleep) and stronger socio-emotional skills. the study pursues two main goals. first, it will develop this innovative, stakeholder-driven health-promotion programme. second, it will test how well the programme works by measuring: (a) children's health-literacy levels, (b) their lifestyle habits (diet, physical activity, sedentary time and sleep), (c) rates of overweight and obesity, and (d) blood-pressure levels. researchers expect that, compared with the control group, children in the intervention group will show higher health-literacy scores, healthier lifestyle patterns and lower rates of excess weight and raised blood pressure. data will be collected before the programme starts and again six months later, using short questionnaires, simple body measurements, blood-pressure readings and a wrist-worn activity tracker (accelerometer) worn for seven days. participation is voluntary, can be stopped at any time without penalty, and all information is handled in accordance with gdpr. social-heroes is funded by fundación "la caixa" (lcf/pr/sr24/57010020) and has ethical approval from the life and health sciences research ethics committee (ceicvs 189/2024). it addresses two pressing challenges at once: reducing early non-communicable-disease risks and narrowing social and educational health gaps among young children. \*teip: priority intervention educational territories in portugal


Eligibility criteria:
inclusion criteria: * children from teip schools * ages between 3 to 6 years old exclusion criteria: * children/families who don't speak/understand portuguese

Keywords: health promotion, health literacy, life style, diet, motor activity, sedentary behavior, sleep, child development, health equity, noncommunicable disease