Kornimate/medical-research-clean huggingface dataset:
longitudinal study of asymptomatic rotator cuff tears

Conditions: Rotator Cuff Tear

Summary: the purpose of this study is to analyze the natural course of asymptomatic rotator cuff tears.

fifty subjects with an asymptomatic rotator cuff tear were identified in an earlier study. clinical, sonographic and mri reexamination of these subjects is performed after an interval of three years. findings of interest include: (1) the symptomatic status of the subjects (still asymptomatic or symptomatic); (2)tear size on sonography and mri (unchanged or increased); (3)degree of muscle atrophy on mri (unchanged or deteriorated); (4)degree of fatty muscle degeneration on mri (unchanged or deteriorated). we want to analyze whether a change in these tear characteristics is associated with a change of the symptomatic status of these subjects.

Eligibility criteria:
inclusion criteria: * subjects with an asymptomatic rotator cuff tear at least in one shoulder, tear demonstrated both on mri and sonography, ases score exceeding 90 points exclusion criteria: * earlier periods with shoulder pain and dysfunction, earlier treatment for shoulder problems

Keywords: rotator cuff tear asymptomatic natural course tear characteristics asymptomatic rotator cuff tears natural course of rotator cuff tears
effect of speed of weight loss on compensatory mechanisms activated during weight reduction

Conditions: Obesity

Summary: obesity has become a global epidemic with huge public health implications. although clinical significant weight loss (wl) can be achieved by a combination of diet and behavioral modification, strong metabolic adaptations, with increased appetite and suppressed energy expenditure, are activated, which compromise wl maintenance and increase the risk of relapse. the aim of this project is to investigate the potential role of wl rate in modulating such responses. more specifically, the investigators want to determine if a similar wl achieved rapidly vs slowly induce the same compensatory responses to weight reduction. a secondary aim is to assess if speed of weight loss can influence motivation. a large battery of assessments will be performed before and after weight reduction including body composition, resting metabolic rate, substrate oxidation, exercise efficiency, fasting and postprandial release of several appetite-regulating hormones, subjective feelings of hunger and fullness and motivation. this project can bring large practical benefits concerning the design of weight loss programs to minimize weight relapse.


Eligibility criteria:
inclusion criteria: * adult (18-50 years old) * obese healthy volunteers (30\<bmi\<45 kg/m2) * weight stable on the last three months (\<2kg), not currently dieting to lose weight and with an inactive lifestyle) exclusion criteria: * history of endocrine/cardiovascular/pulmonary/kidney disease, anaemia, gout, milk intolerance, depression or other psychological disorders, eating disorders, drug or alcohol abuse within the last two years and current medication known to affect appetite or induce weight loss. those with a planned surgery during the study period or participating in another research study will also not be accepted to take part in this study

Keywords: weight loss speed of weight loss metabolic compensation diet therapy
intervention in the management of post-high tuberculosis hospital through educational strategy and oversight distance

Conditions: Pulmonary Tuberculosis; Extra Pulmonary Tuberculosis

Summary: brazil ranks 17th among the 22 countries responsible for 80% of tuberculosis (tb) cases in the world. in 2010, the number of new cases of tuberculosis in brazil was 71,930 and in 4972 rs. in 2010, brazil had a disease incidence of 37.6 / 100,000 in 2011 fell to 36.0 / 100,000. the rio grande do sul(rs)s showed an incidence rate of 46.1 / 100,000 in 2011. the mortality rate was 2.4 / 100,000 population per year in brazil and rs. in porto alegre, the incidence rate of all clinical forms of tuberculosis has remained, in the last six years, around 100/100.000 inhabitants per year, while the coefficient of pulmonary tuberculosis remained on average 50/100.000 inhabitants to year. thus, porto alegre holds the 2nd place in brazil among the capitals with the highest incidence of tb, classifying the city as high risk 5th. porto alegre also has a co-infection tb / hiv from 35.3% one of the highest in the country. the best strategy to prevent new cases of tuberculosis is to invest in early diagnosis and effective treatment of existing cases of the disease. as the treatment of the disease requires daily use of medications for an extended period of time (at least 6 months), adherence becomes the main determinant of the rate of healing of disease. there are several factors that contribute to poor adherence and treatment dropout: alcoholism, illicit drug use, infection with human immunodeficiency virus (hiv human immunodeficiency virus), low education, unemployment, poor housing and prolonged the treatment. the irregular treatment and neglect are the major obstacles to the control and elimination of this disease. study in porto alegre pointed alcoholism, tb / hiv, the fact that the patient does not reside with family and low education as predictors of dropout. the dropout rate in the general population of patients with active tuberculosis was 10.7% (8.0% - 17.0%). abandonment occurred more often within the first three meses8. in porto alegre, 32.5% of new tb cases are diagnosed in hospitals. twenty percent of these patients do not bind, after discharge, the tuberculosis control program (tcp), ie, the patient egress from the hospital does not reach the basic health unit (bhu) reference for further monitoring and treatment, which is considered a serious flaw in the process control of the disease.

primary objective test the impact on the tuberculosis cure rate of an intervention based on education and supervision from a distance in the post-discharge management of new cases diagnosed in hospital.

Eligibility criteria:
inclusion criteria: * patients must be aged over 18 years. * diagnosis in hospital exclusion criteria: * cases where there is change in diagnosis after onset of treatment * cases reintroduction of treatment after default * relapse cases
development and feasibility of a metaverse-based blended online intervention to prevent employees' depression

Conditions: Depression and Suicide Ideation

Summary: the goal of this feasibility study is to develop a new metaverse-based blended online intervention using an online program and coaching via metaverse to prevent depression among generation mz employees in south korea. in addition, this study primarily explores reach and acceptability and secondarily evaluates the preliminary effectiveness of this preventive intervention on korea's gen mz employees.


Eligibility criteria:
inclusion criteria: * generation mz employees of south korea who are aged between 20 and 42; millennials were born between 1981 to 1996, and generation zs were born between 1997 to 2004 exclusion criteria: * 1) being unemployed or having less than 1 year job experience, * 2) having mental disorders such as schizophrenia or substance abuse (as this is a preventive intervention) and currently attending other mental health therapy to avoid mixing effects.

Keywords: depression employee preventive health program digital health suicide
factors affecting the recurrence of acute cholecystitis after treatment with percutaneous cholecystostomy

Conditions: Acute Cholecystitis; Percutaneous Cholecystostomy; Recurrence

Summary: percutaneous cholecystostomy is used to reduce the complications and mortality associated with surgery in patients with high surgical risk in acute cholecystitis. although this method generally acts as a bridge treatment for interval cholecystectomy in patients, interval cholecystectomy is not performed in every patient after percutaneous cholecystostomy. the aim of this study was to determine the recurrence rate of patients who did not have interval cholecystectomy after treatment with percutaneous cholecystostomy and to investigate the factors that may affect the recurrence.

acute cholecystitis is an inflammatory disease of the gallbladder and is often associated with cholelithiasis. according to tokyo guide 2018 (tg18), acute cholecystitis is grouped with various risk factors and predictive factors. early laparoscopic cholecystectomy or late cholecystectomy after medical therapy is recommended for patients with grades 1 and 2. on the other hand, non-operative treatments such as percutaneous cholecystostomy catheter and antibiotic therapy are recommended for selected patients with high surgical risk and serious comorbidities in order to prevent morbidity and mortality. they suggested that percutaneous cholecystostomy catheter could be used as the definitive treatment of acute cholecystitis in these high-risk patients who are not suitable for surgery. debate continues as to whether cholecystectomy is necessary for these patients. because studies have shown that the recurrence rate of acute cholecystitis after percutaneous cholecystostomy catheter treatment varies between 4% and 22%. for these reasons, assessing the risk of recurrence of acute cholecystitis in patients initially treated with percutaneous cholecystostomy is essential to aid decision making.

Eligibility criteria:
inclusion criteria: * diagnosed with acute cholecystitis on admission to the emergency department * patients treated with percutaneous cholecystostomy catheter according to tk18 acute cholecystitis diagnosis and treatment guideline * patients older than 18 years * patients who can give their own consent exclusion criteria: * patients with missing data or not followed up regularly * patients whose cholecystostomy catheter was removed during the operation or operated within the first year following the catheter extraction * patients with choledocholithiasis, abscess secondary to acute cholecystitis, or hepatopancreatobiliary system malignancy * patients who are pregnant

Keywords: acute cholecystitis percutaneous cholecystostomy tokyo guidelines 2018 recurrence
efficacy and safety study of nasacort in chronic non allergic and non infectious rhinitis in adults

Conditions: Rhinitis

Summary: to demonstrate the superiority of the clinical efficacy of 12 weeks' treatment with nasacort versus placebo in adult patients presenting with chronic non allergic and non infectious rhinitis


Eligibility criteria:
inclusion criteria: * patient presenting with chronic non allergic and non infectious rhinitis capable of benefiting from corticosteroid therapy administered via the nasal route. * patient with chronic rhinitis of minimum duration 12 weeks, whether or not consecutive, per year. * patient with non allergic rhinitis confirmed by negative phadiatop test. * patient presenting a mean global score for the 5 symptoms \>= 5 (nasal obstruction, rhinorrhea, disturbance of sense of smell, sneezing, facial heaviness), or mean score for the 3 main symptoms (nasal obstruction, rhinorrhea, disturbance of sense of smell) \>= 5 (mean for 7 days prior to visit v0). * patient presenting an inflammation score at anterior rhinoscopy or nasal endoscopy \>= 4. exclusion criteria: * patient presenting a nasal polyp * patient presenting a severe septal deviation which would interfere with insertion of the nasal spray * patient presenting a nasal cavity tumor * patient presenting a sinus infection * patient presenting a history of endonasal surgery * patient presenting a chronic rhinitis of extrinsic origin (drug-related or food-related rhinitis) or intrinsic origin (hormonal rhinitis, positional rhinitis,atrophic rhinitis, ...) * patient on a program of intensive sports training * patient presenting with : cystic fibrosis, pulmonary mycosis, necrotising vascularitis, immotile cilia syndrome, .... * patient presenting with known immunosuppression, lymphoma * patient presenting with a known cardiovascular, neurological or other medically significant illness * patient presenting with known renal failure, with known glaucoma, with known drug addiction * current antibiotic therapy * corticosteroids administered in the two months prior to admission * patient presenting problems of haemostasis (epistaxis), ophthalmic and/or oro-bucco-nasal herpetic infection. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
chemotherapy - induced peripheral neuropathy

Conditions: Breast Cancer Female

Summary: the purpose of this study was to examine the efficacy of cryotherapy with frozen gloves for the prevention of the chemotherapy-induced peripheral neuropathy (cipn) of the hand. frozen glove was provided for dominant hand of breast cancer patients while receiving paclitaxel treat, and as the experimental group. in addition, another hand as a control group. the questionnaire was used before chemotherapy and at the fourth, eighth, twelfth, and sixteenth weeks to understand the effectiveness of frozen gloves.

in this study, the cryotherapy interventions were based on previous studies, with the dominant hand wearing the frozen glove set as the experimental group, and the non-dominant hand that was not wearing a frozen glove as the control group. the elasto-gel flexible frozen glove (southwest technologies, north kansas city, mo, usa) used in this study lasted for 20 to 40 minutes and was easy to clean.the cold temperature of the refrigerator was measured in advance to be -20.2°c to -22.8°c. the freezing of the gloves lasted for at least three hours, and the gloves were tested with an infrared temperature-measuring instrument before use. its temperature range was -24.3°c to -24.7°c. the patient began to wear gloves 15 minutes before the administration of paclitaxel for one hour, and replaced them with new frozen gloves at the 45th minute. the patient continued to wear the gloves until 15 minutes after the end of the chemotherapy drug administration, for a total of 90 minutes. these intervention procedures were used for each treatment for 12 weeks.

Eligibility criteria:
inclusion criteria: * women with breast cancer diagnosis confirmed by a physician and receiving paclitaxel for the first time. * above 20 years of age. exclusion criteria: * patients with neurological disease histories. * patients with histories of the hand-foot syndrome. * patients with distant cancer metastases or skin metastases. * patients with nail lesions or the absence of fingers. * patients with a low tolerance to cold, and edema.

Keywords: peripheral neuropathy cryotherapy frozen gloves
patient preference study

Conditions: Glaucoma; Ocular Hypertension

Summary: in this randomized crossover study, patients will receive a single drop of two test articles and assess comfort.


Eligibility criteria:
inclusion criteria: * sign informed consent; * diagnosis of glaucoma or ocular hypertension; * on a stable regimen of any intraocular pressure (iop) lowering medication (mono-therapy); * iop for which, in the opinion of the investigator, participation in the study does not present a risk to ocular health; * other protocol-defined inclusion criteria may apply. exclusion criteria: * best corrected visual acuity worse than 0.60 logmar (20/80 snellen) in either eye; * pregnant, nursing, or not using highly effective birth control methods; * use of oral or topical corticosteroids within 30 days of the screening visit and during the course of the study; * history of bronchial asthma or severe chronic obstructive pulmonary disease; * other protocol-defined exclusion criteria may apply.
efficacy of online acceptance and commitment therapy and sound therapy for patients with tinnitus and insomnia

Conditions: Tinnitus; Insomnia

Summary: considering the lack of evidence on the effects of combining acceptance and commitment therapy (act) with customized sound therapy for tinnitus-related insomnia patients, investigators designed this single-blind, 6-months randomized, controlled trial with two parallel groups. one is the act + sound therapy group, and the other is the sound therapy group.

insomnia is one of the most frequent and severe comorbidities in patients with tinnitus and is highly relevant for the perceived tinnitus severity. both tinnitus and insomnia significantly affect the quality of life of patients and represent a huge burden to society. while interventions exist to alleviate tinnitus distress, they often do not address sleep disturbances in tinnitus patients. patients affected by tinnitus and insomnia suffer from long-term functional and psychological problems. sound therapy is widely used to treat tinnitus, often combined with education and counseling, and can effectively improve the quality of life. in addition, acceptance and commitment therapy (act) for tinnitus improves both tinnitus and sleep. however, there is a lack of evidence on the effects of combining act with sound therapy for tinnitus-related insomnia patients. to fully characterize tinnitus patients, standardized measures of tinnitus and insomnia are essential. these measures include pure tone audiometry (pta), acoustic immittance (ai), tinnitus pitch matching (pm) and loudness matching (lm), minimum masking level (mml), tinnitus handicap inventory (thi), insomnia severity index (isi), and hospital anxiety and depression scale (hads). investigators hypothesize that the combination of act and sound therapy will be superiority to sound therapy alone in reducing tinnitus distress.

Eligibility criteria:
inclusion criteria: 1. adults aged between 18 and 80 years old. 2. experiencing subjective tinnitus for at least 3 months. 3. a score of 38 or more on thi. 4. a score of 15 or more on isi. 5. 55 db hl or less on the average pure tone threshold (0.5, 1, 2khz) of the worse ear. 6. ability to read and write in chinese and use a smartphone with an internet connection to work with text material. exclusion criteria: 1. pulsatile tinnitus and objective tinnitus. 2. organic sleep disorders. 3. other diseases that need to be treated first (e.g., infections, tumors, otosclerosis, meniere's disease, the acute stage of sudden sensorineural hearing loss). 4. severe mental illness. 5. undergoing other research that may affect tinnitus and sleep.
workplace based rehabilitation for low back disorders

Conditions: Low Back Pain

Summary: the purpose of this study is to examine the effect of back supports plus education upon recovery from a work-related low back disorder. the study tests the hypothesis: the use of back supports plus health education is not different from health education alone in promoting recovery from a work-related low back disorder in consideration of personal, health, and job factors. significant improvements in physical health, neurogenic symptoms, back pain disability, and low back pain were observed over the twelve months of study follow-up. no statistically significant difference between the study groups was found with respect to these measures.

background low back pain remains a common major source of morbidity and disability. few studies consider the effectiveness of interventions for low back pain while simultaneously considering personal, health, and job characteristics. methods this is a randomized clinical trial in which 433 active employees with low back disorders were randomly assigned to one of two study groups: 1) back support plus education on back health; or 2) education on back health only. demographic, health, medical, and job factors were recorded. outcomes were evaluated over a twelve month period and included self-reported measures of back pain, back pain disability level, physical health, mental health, back pain recurrence and administrative measures. results significant improvements in physical health, neurogenic symptoms, back pain disability, and low back pain were observed over time in both study groups. however, there was no significant difference between the study groups with respect to these outcome measures. the adjusted hazard ratio of recurrence rate was suggestive of an incremental protective effect due to back supports over education alone (adjusted hazard ratio \[ahr\]=0.711, 95% ci 0.50, 1.04, p=.085). there was also a marginal effect of back supports and education on decreasing low back pain over time (ahr=0.0015, p=0.091). conclusions back supports may have some value in promoting recovery from low back pain, but this effect is only observed in individuals who are actively employed in jobs with medium risk of low back disorders.

Eligibility criteria:
inclusion criteria: work-related low back disorder, 18-64 years of age,active hourly worker, enrollment into study within eight weeks of diagnosis, signed informed consent exclusion criteria: no other concurrent work-related condition not pregnant

Keywords: low back pain industrial workers recurrent back pain back supports back health education rehabilitation
intracoronary stenting and additional results achieved by shockwave coronary lithotripsy

Conditions: Coronary Artery Disease

Summary: the clinical trial is intended to evaluate the efficacy, safety and economic benefit of coronary lithotripsy compared to other additional procedures (cutting or super high pressure balloon angioplasty, ablative procedures) in lesion preparation and interventional treatment of severely calcified coronary stenoses.


Eligibility criteria:
inclusion criteria: 1. age ≥18 years and able to give informed consent 2. written informed consent to participate in the clinical trial 3. typical angina pectoris or non-invasive evidence of relevant ischemia under optimal drug therapy 4. angiographic evidence of coronary artery disease 5. de novo lesion in a native coronary artery 6. target vessel diameter 2.5-4 mm 7. severe calcification of the target lesion (angiographic grade 3) exclusion criteria: 1. myocardial infarction \<1 week 2. thrombus in the target vessel 3. life expectancy due to other disease \<1 year 4. simultaneous participation in a clinical trial with medical devices or medicinal products that has not yet been completed 5. pregnancy (current, suspected, planned) or positive pregnancy test

Keywords: coronary artery disease calcified lesion percutaneous coronary intervention stent intravascular lithotripsy