Kornimate/medical-research-clean huggingface dataset:
the effect of polycystic ovary syndrome treatment on metabolomics

Conditions: Polycystic Ovary Syndrome

Summary: the aim of this study is to determine the effect of the treatment of polycystic ovary syndrome with two different oral contraceptives that contain cyproterone acetate and drospirenone

polycystic ovary syndrome (pcos), is the most common endocrinological disorder that affects the reproductive aged women. in addition to causing problems such as menstrual irregularity, hirsutism, acne, it is also an important health problem that can cause infertility, insulin resistance, impaired glucose metabolism, diabetes, high blood pressure, heart disease, dyslipidemia in advanced ages. diagnostic criteria also vary widely in these patients. these patients are often overweight or obese, and abdominal adiposity is common in these patients. the patients also suffer from insulin resistance and hyperinsulinemia in this syndrome. all of this is probably the result of a vicious cycle that starts in the antenatal period. combined oral contraceptives (cocs), are the first-choice treatment option for many patients by improving both menstrual irregularity, hyperandrogenism, and insulin resistance through sex hormone binding globulin (shbg). they reduce the risk of endometrial hyperplasia and endometrial cancer by providing regular menstruation. nowadays, the use of metabolomics is increasing in understanding the pathophysiology of diseases. metabolomics technology examines low molecular weight substrates used in intracellular enzymatic reactions, intermediates and end products resulting from these reactions. metabolomic examinations are gaining momentum in terms of understanding the pathophysiology of diseases, especially endometrial cancer and ovarian cancer, in the field of obstetrics and gynecology. metabolomics continue to be investigated in understanding the pathophysiology of pcos, but there are not enough studies yet on the effects of treatment on the disease in terms of metabolomics.

Eligibility criteria:
inclusion criteria: * patients who are diagnosed with polycystic ovary syndrome according to rotterdam criteria and who do not have any additional chronic systemic disease exclusion criteria: * the presence of any diseases that cause hormonal disorders and any chronic systemic diseases, the patients who are already under any treatment for polycystic ovary syndrome

Keywords: hirsutism combined oral contraceptives amenorrhea
a randomized air filter intervention study of air pollution and fetal growth in a highly polluted community

Conditions: Fetal Growth Restriction

Summary: the purpose of this study is to use an air filter intervention to evaluate the relationship between particulate matter air pollution exposure during pregnancy and fetal growth. we hypothesize that: 1) portable high efficiency air (hepa) filters will produce major reductions in home indoor concentrations of particulate matter and 2) pregnant women whose exposures to particulate matter are reduced by this intervention will give birth to children with greater mean body weight for gestational age. in an extended follow-up of this cohort, we aim to evaluate the relationship between use of portable air purifiers during pregnancy and the growth and development of children from birth to age four years. in particular, the follow-up study will focus on children's physical growth, respiratory symptoms, and behavioral, social and neurocognitive development.


Eligibility criteria:
inclusion criteria: * adult (\>18 years) * pregnant woman in first trimester (\<14 weeks) * single gestation pregnancy * non-smoker exclusion criteria: * multiple-gestation pregnancy * current smoker * currently operating an air filter in the home * currently living in a ger (traditional mongolian felt-lined yurt) * plan to give birth outside of a hospital or clinic in ulaanbaatar

Keywords: air pollution particulate matter mongolia pregnancy intrauterine growth restriction (iugr) fetal growth birth weight gestational age obesity iq autism wheeze
the presence and role of zygomatic-temporal neuroma triggering cluster headache

Conditions: Cluster Headache; Craniofacial Pain Syndrome

Summary: role of a neuroma of zygomatic-temporal in triggering of a cluster headache. exploratory diagnosis, resection, and pathological examination of tumor anticipated .

an anatomical coordinated communication of a cluster circuit turned on by zygomatico-temporal neuroma, a malicious possibly nontraumatic, neoplastic tissue coding and decoding itself upon autonomic release of neurotransmitter(s). exhaustion of neurotransmitter synthesis turns out the explosions of pain-symptoms off. poor attention to the characterization of a peripheral neuroma of trigeminal nerve branch deranged attention to central(cns) characterization of cluster symptoms. this study based on our experimental results of minimal surgical procedure to explore, diagnose and resect a zygomatico-temporal neuroma in the temple of patients suffering from episodicchronic, cluster headache-ecch. the goal is to light on this speculation in a novel analysis of events to put an end to devastating catastrophic headaches. detailed anatomical components loci of the autonomic symptoms in the cluster headache reveal the presence of an electrical neural circuit. the extracranial circuit components of ecch reflects the anatomical nerve components participating reflection of the single circumscribed symptom: 1. zygomatico-temporal-neuroma 2. zygomatic nerve v-ii 3. intraorbital communicants rami 4. lacrimal nerve v-i 5. ophthalmic nerve intraorbital routing, supraorbital nerves, the upper eyelid, the conjunctiva and cornea of the eye, the nose (including the tip of the nose, except alae nasi), the nasal mucosa, the frontal sinuses. v-i 6. optic nerve via ophthalmic nerve routing and electricity propagation. 7. pterygopalatine ganglion as peripheral and cns coordinator center. an intracranial cns reaction follows in response to the perception of pain materialized in neuroimaging during the activity of ecch.

Eligibility criteria:
inclusion criteria: - cluster headache exclusion criteria: * malignant hypertension, * brain tumors, * cerebral vascular abnormalities, * presence of a brain or nerve electro stimulator.

Keywords: cluster headache neuralgic headache
reliability and validity study for swe of shoulder muscles in persons after stroke.

Conditions: Stroke

Summary: this study aims 1. to examine the reliability of swe assessment in the shoulder muscles of persons after a stroke. 2. to assess if differentiation can be made between the hemiplegic (hp) and non-hemiplegic (nhp) side and between stroke patients and matched healthy volunteers (discriminative validity). 3. to assess if an immediate effect on the pectoralis major and minor can be measured after applying transversal stretch technique to the pectoralis major muscles (response validity).

stroke patients will be assessed on 2 days with an interval of 3 days (friday - monday). day 1 (friday): shear wave velocity (swv) will be assessed by 2 assessors in randomised order. each assessor will evaluate swv of 6 shoulder muscles (m. supraspinatus, m. infraspinatus, m. rhomboid major, m. deltoideus, m. pectoralis major, m. pectoralis minor). at the end of the assessment secondary outcome measures will be assessed. day 2 (monday): swv will be reassessed by assessor 1 to measure test-retest reliability. position of the patient will be changed. swv of the pectoralis major and minor muscle will be reassessed. assessor 2 will perform a transversal stretch of the m. pectoralis major or a passive mobilisation of the hand at the hemiplegic arm of the stroke patients. assessor 1 will reassess the swv of the pectoralis major and minor muscle to assess if there is an immediate effect of the intervention. assessor 1 will be blinded for the intervention. healthy controls (matched for age, gender and bmi): only one test day to assess swv of 6 shoulder muscles. secondary outcome measures will be assessed after swe assessment.

Eligibility criteria:
stroke group inclusion: * stroke patients in the subacute phase after stroke (\< 6 months post stroke) * able to sit independently with support of the back, but without support of the arms * with upper-limb (ul) impairment: i.e. no maximum score (36) on the shoulder elbow part of the fugl-meyer ul (fm ul) exclusion criteria: * other neurologic disorders * shoulder or neck surgery before stroke onset * arthroscopic surgery in the last year before stroke onset. * shoulder or neck pain in the last year before stroke onset. * severe cognitive or language deficits that inhibit the participants of understanding simple commands or providing valuable information regarding the outcome measures - measured with the ability q. * participants who are not able to maintain the test position. * pregnancy healthy controls can participate if they * have not suffered a stroke or other neurological disorders * did not have surgery at the shoulder and/or neck * did not have arthroscopic surgery in the last year before stroke * if they do not suffer any shoulder or neck pain

Keywords: stroke shear wave elastography shoulder muscles shoulder pain
day-care unit for patients with refractory heart failure

Conditions: Heart Failure; Heart Diseases; Cardiovascular Diseases

Summary: the day-care unit for patients with refractory heart failure (daycare-hf) is an observational study on selected patients with advanced refractory heart failure. the purpose of the study was to examine the comprehensive management of hf in the day-care unit in terms of the safety and its impact on the rehospitalization and mortality rates in patients with advanced refractory hf.

the day-care unit for patients with refractory heart failure (daycare-hf) is a single-center observational study conducted in the 3rd department of cardiology, school of medicine with the division of dentistry in zabrze, medical university of silesia in katowice, silesian centre for heart disease in zabrze, poland. the main objective of the daycare-hf is to verify the hypothesis that comprehensive and multidisciplinary day-care management of patients with refractory heart failure (hf) is safe and beneficial in terms of hospital readmission due to hf and al cause mortality. the study population is formed by selected patients with heart failure, hospitalized in cardiology wards and intensive cardiac care unit of silesian centre for heart disease, who fulfilled eligibility criteria. during the scheduled visits comprehensive medical service is provided, including education, diagnostic tools (electrocardiography, transthoracic echocardiography, implanted cardioverter defibrillator (icd) / cardiac resynchronization therapy device (crt) interrogation and additional treatment (intravenous loop diuretic, dobutamine, vasodilators administration). the patients are under constant follow-up for major adverse events, heart transplantation, hospital readmissions due to hf and all cause mortality.

Eligibility criteria:
inclusion criteria: 1. optimally decongested heart failure in new york heart association (nyha) class ii-iv, treated for at least 6 months 2. performance of all possible reparative procedures if indications were present (cardiac revascularization, correction of valvular heart disease, cardiac ablation, cardiac resynchronization therapy) 3. implantation of cardioverter-defibrillator (icd) if applicable 4. at least two unplanned hospitalizations for heart failure during preceding 6 months exclusion criteria: 1. inability to travel to the unit 2. non-compliance with the medical recommendations

Keywords: heart failure day care prognosis
rheumatologists and the requesting of antinuclear antibodies (ana) tests in patients with rheumatologic complaints

Conditions: Rheumatic Diseases

Summary: the aim of this study is to assess the effect of a simple intervention (a combination of education and feedback) on antinuclear antibody (ana) testing. this aim was chosen because of the known overuse of many laboratory tests, of which ana testing is one. as overuse of ana tests can have negative consequences (both for patients and society), the investigators designed an intervention to see how this would influence antinuclear antibody testing by rheumatologists.


Eligibility criteria:
inclusion criteria rheumatologists: * rheumatologists who are consulting patients at the rheumatology outpatient clinic of a participating centre exclusion criteria rheumatologists: * rheumatologists not working the full study period (pre- and post-intervention) at a participating centre * rheumatologists not giving their consent to participate inclusion criteria patients - all patients with an ana test requested by an included rheumatologist during the study period exclusion criteria patients - patients with an ana test requested during a clinical admission

Keywords: antinuclear antibody (ana) overuse rheumatologists quality of care
a study comparing iop-lowering treatments to bimatoprost in patients with primary open angle glaucoma or ocular hypertension

Conditions: Glaucoma, Open-Angle; Ocular Hypertension

Summary: an observational study comparing changing from an iop-lowering treatment to a bimatoprost-containing iop treatment in primary open-angle glaucoma (poag) or ocular hypertension (oht). visits and treatment are per normal clinical practice.


Eligibility criteria:
inclusion criteria: * diagnosis of poag or oht * previous use of iop-lowering medication exclusion criteria: * none
predicting tolerance to radiation therapy in older adults with cancer

Conditions: Pre-treatment Loss of Independent Activities of Daily Living

Summary: a comprehensive geriatric assessment tool developed by hurria and colleagues has been used in non-radiation oncology clinical settings to predict how older adults tolerate cancer treatments. the investigators think this same tool (referred to as the cga) can be used in a radiation oncology clinic to predict for poor treatment tolerance.

a comprehensive geriatric assessment tool developed by hurria and colleagues has been used in non-radiation oncology clinical settings to predict for toxicity in older patients during cancer treatments.1 the investigators hypothesize that the same tool (referred to throughout this document as the cga) can be used in a radiation oncology clinic to predict for poor treatment tolerance. the primary objective of this study is to assess the association between pre-treatment functional status (as measured by the independent activities of daily living (i-adl) components of the cga) and poor tolerance to radiation therapy (as defined in section 2.3.1). secondary objectives include exploration of associations between pre-treatment i-adl status on the cga and the occurrence of any acute grade 3-5 toxicity from radiation therapy, or any decrease in quality of life (qol) measures throughout radiation therapy as assessed by the eortc qlq-c30 questionnaire. the investigators also want to compare the rate of physician reported acute toxicities to patient reported acute toxicities in an older cancer patient population, assess any association between elevated p16ink4α expression in peripheral t lymphocytes and poor tolerance to or acute grade 3-5 toxicity from radiation therapy, and explore any association between other baseline components of the cga and poor tolerance to or acute grade 3-5 toxicity from radiation therapy.

Eligibility criteria:
inclusion criteria: * ≥age 65 years (no upper age limit) * diagnosis of either head and neck cancer, or lung cancer with either radiotherapy or chemoradiotherapy planned as part of standard treatment. * consented for receipt of external beam radiation therapy (ebrt) at unc chapel hill * able to read english (required for cga) * curative treatment intent as defined by their radiation oncologist signed, irb-approved written informed consent * patients enrolled in other cga studies will not be excluded (see lccc 0916, 1208) exclusion criteria: * ≥age 65 years (no upper age limit) * diagnosis of either head and neck cancer, or lung cancer with either radiotherapy or chemoradiotherapy planned as part of standard treatment. * consented for receipt of ebrt at unc chapel hill * able to read english (required for cga) * curative treatment intent as defined by their radiation oncologist signed, irb-approved written informed consent * patients enrolled in other cga studies will not be excluded (see lccc 0916, 1208)

Keywords: neck cancer head cancer lung cancer
follow up of nasolacrimal intubation in adults

Conditions: Lacrimal Apparatus Diseases; Dacryocystitis

Summary: for patients with chronic epiphora, dacryocystorhinostomy is currently the gold standard treatment, with a success rate of 80-90% according to literature. another available treatment, which is far less used, in nasolacrimal intubation, using a silicone tube. in our study, we would like to find the efficacy of nasolacrimal duct intubation, which was performed in our medical center on a few hundred patients with mild epiphora. study hypothesis: nasolacrimal intubation in adults, with a clinically mild epiphora, is close in it's efficacy to the dacryocystorhinostomy procedure.

under normal conditions, the amount of tears excreted from lacrimal glands to the eye is equal to the amount drained through the tear duct. epiphora in adults usually involves a blockage of the lacrimal sac or the nasolacrimal duct. epiphora causes tearing in patients, which can be treated sympthomatically in a conservative way (antibiotic treatment, probing of the tear duct, pressure irrigation of the tear duct) or therapeutic in an invasive way. the invasive treatment includes one of the following: 1. dacryocystorhinostomy - surgery for reconstructing an alternative path for tear drainage. 2. nasolacrimal intubation - inserting a silicone tube through the tear duct. the tube is usually removed after 3-6 months. currently, there are only a few reports regarding the efficacy of nasolacrimal intubation, all with a small number of research subjects. also, these reports have stratified the patients according to the location of the tear duct blockage, and didn't take into account the severity of the blockage (ie the severity of symptoms) prior to performing the intubation. in our research, we would like to find the efficacy of nasolacrimal intubation which was performed in our medical center on a few hundred patients with mild epiphora, and to compare in with the efficacy of the dacryocystorhinostomy - which is 80-90% according to literature.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of mild epiphora. * underwent nasolacrimal intubation during 01/2000 - 12/2007. exclusion criteria: * purulent excretions from nasolacrimal duct on day of admission or intubation. * nasolacrimal intubation in the past. * dacryocystorhinostomy in the past.
dose escalation study of lgh447 in japanese patients with relapsed and/or refractory hematologic malignancies

Conditions: Multiple Myeloma

Summary: this is a multi-center, open-label, dose escalation, phase 1 study of oral lgh447 in japanese patients with relapsed and/or refractory multiple myeloma for which no standard effective treatment options exist. the study consists of a dose escalation part to estimate the maximum tolerated dose and/or the recommended dose for expansion and a dose expansion part to further assess safety and preliminary anti-cancer activity of lgh447 at the maximum tolerated dose and/or the recommended dose for expansion.


Eligibility criteria:
inclusion criteria: -confirmed diagnosis of relapsed and/or refractory mm for which no standard effective treatment options exist. exclusion criteria: -uncontrolled cardiovascular condition, including ongoing cardiac arrhythmias, congestive heart failure, angina, or myocardial infarction within the past 6 months.

Keywords: multiple myeloma, phase i, pim, japanese patients, lgh447
paracervical versus intracervical lidocaine

Conditions: Abortion, Induced; Pain

Summary: the aim of this study is to estimate the efficacy of intracervical versus paracervical block on pain experienced during first trimester suction curettage without the use of preoperative cervical ripening. because of the theoretical improved reliability of stromal block, the investigators hypothesize that intracervical block would produce lower pain scores than paracervical block at the time of cervical dilation.


Eligibility criteria:
inclusion criteria: * women presenting for elective first trimester abortion exclusion criteria: * gestation over 12 weeks by ultrasound * weight less than 98 pounds * known allergy to lidocaine * known nonviable pregnancy

Keywords: local anesthesia paracervical intracervical abortion pain local anesthesia for elective first trimester abortion
clinical characteristics and prognostic factors of patients with covid-19 (coronavirus disease 2019)

Conditions: COVID-19 Infection

Summary: this is a multicenter, non-interventional, retrospective study using data captured in the ehrs (electronic health records) of the participating hospital sites to determine factors that predict disease prognosis and outcomes in covid-19 patients, specifically: hospitalization/off-site monitoring, transfer to icu and/or need for medical mechanical ventilation (both invasive and non- invasive), length of icu stay, and outcome (cure/ hospital discharge, in-hospital death)

data captured in the ehrs will be collected from all available departments, including inpatient hospital, outpatient hospital, emergency room, etc. for virtually all types of provided services in each participating site. the study period will be from january 1, 2020 to the most recent data available. * primary objective to determine factors that predict disease prognosis and outcomes in covid-19 patients, specifically: hospitalization/off-site monitoring, transfer to icu and/or need for medical mechanical ventilation (both invasive and non- invasive), length of icu stay, and outcome (cure/ hospital discharge, in-hospital death) * secondary objectives * to describe the demographic and clinical characteristics of covid-19 patients * to describe the patient management (treatment and procedures) in the target population * to describe the outcomes of covid-19 (discharge, hospitalization, transfer to icu/ mechanical medical ventilation, in-hospital death) in relation to patients' clinical and demographic characteristics, and treatment received * to determine whether the factors that predict covid-19 prognosis and outcome also apply to other types of pneumonia. * exploratory objectives one of the goals of this study is to configure the big data system to unravel any hidden variable/s (and their associations) that may offer novel clinical insights into covid-19 management.

Eligibility criteria:
inclusion criteria: * all patients with suspected covid-19 infection, as captured in the patients' ehrs of the participating sites. exclusion criteria: * not suspected covid-10 infection

Keywords: artificial intelligence electronic health record intensive care unit natural language processing machine learning real-world evidence sars-cov-2 (severe acute respiratory syndrome coronavirus 2) covid-19
observational study of patients using levemir® or insulatard® as start insulin for treatment of diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in europe. the aim of this observational study is to evaluate the glycaemic control, weight change and hypoglycaemic effects in patients with type 2 diabetes with levemir® compared to insulatard® under normal clinical practice conditions.


Eligibility criteria:
inclusion criteria: * type 2 diabetes failing on oral blood glucose lowering therapy, and requiring insulin therapy. exclusion criteria: * type 1 diabetes * previous use of insulin