Kornimate/medical-research-clean huggingface dataset:
effect of extracorporeal shockwave therapy on tension-type headache in adolescent females

Conditions: Tension-Type Headache

Summary: chronic headaches in adolescents can have consequences such as absence from school, inability to maintain social activities, and additional disorders such as anxiety, depression, problems sleeping, and reduced quality of life to investigates the efficacy shock wave diathermy on tension headaches in adolescent females

the prevalence of headaches increases with age, with a prevalence of 82% during adolescence. extracorporeal shockwave therapy could reduce the pain of myofascial pain syndrome by pain signal alteration, promoting angiogenesis and increasing perfusion in ischemic tissues induced by sensitization of nociceptors and muscle ischemia

Eligibility criteria:
inclusion criteria: * suffering from chronic tension headache (headaches occur 15 or more days a month for at least three months). * their age will range from 15 to 18 years. * having a sedentary lifestyle (a weekly physical activity of \< 600 met-minutes/ week in the international physical activity questionnaire) * having regular menstruation (28 to 34 days). exclusion criteria: * using oral contraceptives or * any hormonal treatment in the previous six months.
randomized study of integration success of osseotite dental implants placed using different insertion procedures

Conditions: Partial Edentulism; Tooth Disease

Summary: osseotite implants placed with higher insertion torque (test procedure) will have higher initial stability and integration success than those placed with lower insertion torque forces.

osseotite implants will be placed using the standard lower insertion torque forces and compared to implants placed using higher insertion torque forces.

Eligibility criteria:
inclusion criteria: * patients of either sex and older than 18 years of age * patients needing a minimum of 3 implants to treat partial edentulism * patients physically able to tolerate surgical and restorative dental procedures * patients agreeing to all protocol visits exclusion criteria: * patients with infection or severe inflammation at the intended treatment sites * patients smoking greater than 10 cigarettes per day * patients with uncontrolled diabetes mellitus * patients with uncontrolled metabolic diseases * patients who received radiation treatment to the head in the past 12 months * patients needing bone grafting at the intended treatment sites * patients known to be pregnant at screening visit * patients with para-functional habits like bruxing and clenching

Keywords: edentulism dental implants early loading crestal bone level high torque insertion low torque insertion randomized osseotite clinical study
contribution of the kinematic theory in the early differential diagnosis of the parkinson's disease

Conditions: Parkinson Disease; Healthy; Parkinsonian Syndromes

Summary: the working hypotheses are as follows: #1 the processing of performance signals by automated lognormal segmentation and the extraction of the parameters of interest will make it possible to distinguish groups of patients from healthy elderly subjects. #2 the three instrumental approaches will not have the same degree of reliability as a predictive biomarker of clinical diagnosis established by consensus.

the strength of this study is to compares three refined parametric approaches drawn from functions mediated by very different neuromuscular programs (visually guided voluntary movement control to perform trajectories with the hand or arm versus vocal control) among two groups of patients and a healthy group. its weakness lies in the lack of multimodal methods to accurately confirm clinical diagnosis and the predictive reliability of patient performance. these modalities are too costly to be included in this project. however, different oculovisual measurement standards such as optical coherence tomography, hyperspectral imaging (optina diagnostics inc.), and eye tracking will be used at the school of optometry, university of montreal. there is indeed a remodeling of the retina and oculomotor changes in parkinson's disease (pd) and these non-invasive techniques, which have been accepted for several years, will be used in patients in support of their clinical diagnosis compared to normal subjects.

Eligibility criteria:
inclusion criteria: * being diagnosed with parkinsonism including idiopathic parkinson's disease or a related syndrome; * have motor symptoms of parkinsonism for 6 years or less; * be a healthy volunteer subject in good general health with no prior neurological history; * age between 50-75 years old; * if applicable, be able to safely leave home in the morning without having taken antiparkinsonian medication for the past 12 hours. exclusion criteria: * major neurocognitive disorders; * history of other neurological conditions, such as ischemic or hemorrhagic stroke, paralysis of a limb, traumatic brain injury, epilepsy, orofacial dystonia, essential tremor; * history of oromandibular or laryngeal procedures; * uncorrected deafness; * any contraindication to pupillary dilation.
relationship between serum vitamin d and outcomes of liver transplantation in cirrhotic patients undergoing liver transplantation and effects of vitamin d supplementation in post-transplant period

Conditions: Liver Transplant; Complications; Vitamin D Deficiency

Summary: the study population is patients with liver cirrhosis undergoing liver transplantation; in this study, the sample will be selected from cirrhosis patients undergoing liver transplantation in taleghani (tehran), imam khomeini (tehran) and abu ali sina hospitals(shiraz). this study uses the recorded information of patients with cirrhosis who have undergone liver transplantation so far and have inclusion criteria and no exclusion criteria. first, we extract demographic and clinical and pathophysiological information of patients, including age, sex, bmi, cause of cirrhosis, medical status at the time of liver transplantation, history of abdominal surgery, portal vein thrombosis, and waiting time for liver transplantation. in the next step, we examine the serum level of vitamin d in different age and sex groups and determine the prevalence of vitamin d deficiency for each group. it should be noted that in this study, the serum level of 25-hydroxy vitamin d below 20 ng/ml will be considered an insufficient level. in the next step, in patients 12 years of age and older, according to serum bilirubin, serum creatinine, serum sodium and inr, we calculate the meld-na score and evaluate it with the serum level of vitamin d or 25-hydroxy vitamin d. we also use peld scores in patients younger than 12 years of age, which consist of age, serum albumin, total bilirubin, inr, and stunted growth. follow-up will be done by calling the patients and recruitment every 3 month. acr or acute cell rejection is usually suspected after elevated liver enzymes (serum aminotransferases, alkaline phosphatase, gamma glutamyl transpeptidase) or bilirubin (30). the incidence of acr and overall survival (os) will be considered as the end point of the first phase of the study, and finally the incidence of 25-hydroxy vitamin d before transplantation with meld-na or peld score will be examined. acr and os, we deal with statistical tests. in the second phase of the study, which is a clinical trial, 50 sample patients with vitamin d deficiency will be selected from taleghani hospital; after transplanting, we will inject 300,000 units of vit d im and compare their acr and os levels with those who have been deficient in vitamin d but whose vitamin d status has not improved. it is worth mentioning that in the second phase of the study, patients will be followed up to 3 months after liver transplantation.


Eligibility criteria:
inclusion criteria: * esld underwent liver transplantation * creatinine, bilirubin and inr measured * measured liver enzymes such as serum aminotransferases, alkaline phosphatase, gamma glutamyl transpeptidase / or bilirubin exclusion criteria: * people with acute liver failure * people who have had multiple organ transplants * primary graft non-function (pnf) individuals

Keywords: vitamin d liver transplantation
a study of ly3127804 with ramucirumab in participants with advanced solid tumors

Conditions: Solid Tumors

Summary: the main purpose of this study is to evaluate the safety of the study drug known as ly3127804 given as monotherapy and in combination with ramucirumab for participants with advanced or metastatic solid tumors. the study will also include a safety exploration for the combination of ly3127804 plus ramucirumab and paclitaxel


Eligibility criteria:
inclusion criteria: * have a diagnosis of cancer that is advanced and/or metastatic. * have disease as defined by the response evaluation criteria in solid tumors (recist ) version 1.1. * have adequate organ function. * have an eastern cooperative oncology group (ecog) performance status of 0 or 1. * have discontinued previous treatments for cancer for at least 28 days or 5 half-lives prior to study enrolment. exclusion criteria: * have serious preexisting medical conditions. * have received treatment with a drug predominantly targeting ang2 activity. * have symptomatic central nervous system (cns) malignancy or metastasis. * have current hematologic malignancies. * have an active fungal, bacterial, and/or known viral infection. * have a corrected qt interval using fridericia's correction (qtcf) of \>470 msec on screening electrocardiogram (ecg) at several consecutive days of assessment. * have a known sensitivity to mabs or other therapeutic proteins. * have a history of hypertensive crisis or hypertensive encephalopathy or current poorly controlled hypertension despite standard medical management. * have a significant bleeding disorder or vasculitis or had a grade ≥3 bleeding episode within 3 months prior to receiving treatment. * receive anticoagulation therapy at therapeutic dose. * have experienced any arterial or venothrombotic or thromboembolic events within 6 months prior to study treatment. * have liver cirrhosis with a child-pugh class b or worse or cirrhosis (any degree) and a history of hepatic encephalopathy or clinically meaningful ascites resulting from cirrhosis. * the participant is pregnant prior to randomization or breastfeeding. * the participant has sensory peripheral neuropathy ≥ grade 2 (part e only).

Keywords: advanced, angiopoietin
an observational study of mabthera/rituxan (rituximab) in patients with follicular lymphoma

Conditions: Lymphoma, Follicular

Summary: this observational study will evaluate the safety and efficacy of mabthera/rituxan (rituximab) in previously untreated patients with follicular lymphoma. data will be collected for 3 years


Eligibility criteria:
inclusion criteria: * adult patients, \>/=18 years * patients with previously untreated follicular lymphoma (stage iii-iv) according to the approved summary of product characteristics (spc) exclusion criteria: * contraindications to mabthera/rituxan therapy according to the approved spc
protect chronic tibial nerve stimulator (ctns) system

Conditions: Urge Incontinence

Summary: 30 patient study. all patients implanted with stimguard protect system. patient followed out to 90 days.

the proposed therapy is called chronic tibial nerve stimulation (ctns), which is a low-risk, minimally invasive chronic implant for the treatment of urgency urinary incontinence. ctns works by the same mechanism as percutaneous tibial nerve stimulation (ptns), but is provided for chronic use with an implantable device. ctns treatment involves the placement of a minimally invasive stimulator with an embedded receiver at the tibial nerve. the protect ctns system has an external transmitter that activates the implanted stimulator and sends mild electrical pulses to the tibial nerve. these impulses travel to the sacral nerve plexus, the group of nerves at the base of the spine responsible for bladder function. since stimulation with the protect ctns system is chronic it is expected that bladder activity can be changed more quickly and without the frequency of treatments related to ptns.

Eligibility criteria:
inclusion criteria: * diagnosis of overactive bladder with urgency urinary incontinence exclusion criteria: * primary complaint of stress urinary incontinence

Keywords: efficacy implantable wireless neuromodulation device tibial
safety study of a sensitive sensual touch and personal lubricant

Conditions: Inadequate Lubrication

Summary: this is a one week study designed to test the safety of a personal lubricant during in-home use for subjects who perceive themselves as having sensitive skin.

this is a single-center, medically supervised, single-arm study to evaluate the safety of an all over 2-in-1 sensual touch lotion and personal lubricant product in home-use conditions via clinical assessment. the study will consist of two visits. subjects who meet the entrance criteria will receive investigational product (ip) and four subjective questionnaires for at-home completion. the subjects will be required to use the ip at least two times on each application site, as instructed over the 1-week home-use period. at the end of the study (visit 2) subjects will return to the study site, at which time all unused ip and questionnaires will be returned and a final clinical assessment will be performed.

Eligibility criteria:
inclusion criteria: * normal, healthy adults in a stable, monogamous, ongoing heterosexual relationship with current partner for at least 6 months * subjects comfortable discussing sensitive topics such as personal hygiene, menstruation and sexuality * at least one partner in the couple has sensitive skin per protocol-defined criteria * able to read and understand english * voluntarily signs an informed consent document after the trial has been explained * willing to follow all study procedures, including birth control requirements exclusion criteria: * any medical or mental health history or condition, or use of any product, drug or medication that per protocol (or in the opinion of the investigator) might compromise the participant's safety or the analysis of results * participation as a research subject within timelines dictated by protocol * participants with relationships or employment outside protocol-defined parameters

Keywords: lubricating agents personal lubricant
intestinal barrier function and liver cirrhosis

Conditions: Liver Cirrhosis

Summary: patients with liver cirrhosis have an increased risk to develop life-threatening complications such as spontaneous bacterial peritonitis (sbp). impairment in the intestinal barrier, changes in numbers and composition of the intestinal microbiota and alterations in immune defenses have been suggested to be involved in liver cirrhosis and its complications. dysfunction in the intestinal barrier for example results in the ongoing passage of toxic substances from the gastrointestinal tract that may damage the liver, leading to oxidative stress, inflammation and eventually liver cirrhosis. in addition, bacterial translocation is considered a key step in the development of spontaneous infections, mainly sbp, in patients with liver cirrhosis. the investigators hypothesize that patients with decompensated liver cirrhosis have a more impaired intestinal epithelial barrier and altered intestinal microbiota than patients with compensated liver cirrhosis.


Eligibility criteria:
inclusion criteria: * liver cirrhosis of any cause * a score of greater-than or equal to 5 assessed according to the child-pugh classification * age between 18 and 65 years exclusion criteria: * known gastrointestinal diseases (such as inflammatory bowel disease and celiac disease), chronic renal disease (i.e. a glomerular filtration rate of less-than or equal to 60 ml/min per 173 m2 estimated from the modification of diet in renal disease (mdrd) equation) or diabetes mellitus * major abdominal surgery interfering with gastrointestinal function (except for uncomplicated appendectomy, cholecystectomy and hysterectomy, other surgery upon judgement of the principle investigator)

Keywords: liver cirrhosis intestinal permeability microbiota complications
early warning system for allergic rhinitis in the mask-air® app

Conditions: Allergic Rhinitis

Summary: the primary objective consists in the comparison of the combined symptom medication score values between (i) patients randomised to the early warning system personalised forecasting messages, and (ii) patients randomised to generic messages already delivered by mask-air®. the combined symptom medication score has recently been developed in a data-driven way and validated (https://eaaci.org/images/csms.pdf); it assesses allergic rhinitis control taking into account both reported symptoms and medication use. as secondary objectives, visual analogue scales on allergic rhinitis symptoms (vas global, nasal, eye, asthma), and medication use will also be separately compared.

in patients with allergic rhinitis, forecasting potential exacerbation of symptoms may allow patients to adopt the most adequate preventive measures. in this context, we are developing an early warning system combining atmospheric, pollen, patient symptoms and online activity data. this early warning system will be incorporated in a mobile health app, and aims to provide patients with messages indicating whether exacerbations are expected in the subsequent five days. to test the effectiveness of the early warning system in avoiding a worsening of patients' symptoms, undertaking a randomised controlled trial is warranted, particularly comparing personalised forecasting messages versus generic messages. the clinical study will assess an early warning system, which will be developed through the catalyse project. this early warning system will be incorporated in mask-air®, a mobile health app implemented in 19 european countries, and which allows for patients to register their daily allergic rhinitis symptoms(rhinitis, conjunctivitis and asthma) and medication. the early warning system will be based on: patients' symptom information (as registered in mask-air®); and atmospheric and pollen forecasts provided by silam model and copernicus systems (which are able to provide forecasts for six main allergic pollen types in europe, and is able to assimilate new observations registered with an hourly time resolution).

Eligibility criteria:
inclusion criteria: - adult patients (≥18 years old) of both sexes with clinical diagnosis of allergic rhinitis according to aria associated with pollen allergy. exclusion criteria: * illiterate patients * patients without smartphone * patients who are not able to complete a daily monitoring questionnaire on allergic rhinitis.
use of antibacterial cement in infected dentin

Conditions: Dental Caries

Summary: dental materials with antibacterial properties can prevent the harmful effects caused by oral cariogenic bacteria. this double-blind controlled clinical trial evaluated the performance of antibacterial cement for sealing infected dentin in atraumatic restorations of primary molars.

the study enrolled 45 children (45 teeth) between 5 and 8 years of age, of both genders, divided into two groups. in group a (ga; n=22), the cavities were lined with conventional glass ionomer cement (vidrion f®) and in group b (gb; n=23), with antibacterial cement (vidrion f® containing 1% each of metronidazole, ciprofloxacin, and cefaclor). both groups were restored with ketac molar easymix®. molars with carious lesions on the inner half of dentin without clinical or radiographic pulp damage were selected. patients were evaluated clinically (for pain, fistulas, or mobility) and radiographically (area of caries, periapical region, and furcation of teeth) after 1, 3, 6, and 12 months.

Eligibility criteria:
inclusion criteria: * signed consent from a parent or guardian; * primary molars with carious lesions on the inner half of dentin; * access of caries lesions to dentin spoons. exclusion criteria: * damaged pulp determined clinically (for pain, fistulas, tooth mobility); * damaged pulp determined radiography (bone or dental pathology); * children taking antibiotics; * children who refused the treatment; * children had systemic disease.

Keywords: antibacterial agents deciduous teeth clinical trial
metabolic effects of exogenous 3-hydroxybutyrate in patients with type 1 diabetes and healthy controls

Conditions: Type 1 Diabetes Mellitus; Diabetic Ketoacidosis

Summary: the main objective of this clinical trial is to study the metabolic effects of intravenous infusion of the ketone body, 3-hydroxybutyrate (3-ohb), in patients with type 1 diabetes and healthy control subjects. moreover, the investigators plan to examine regulatory mechanisms of 3-ohb that may be related to diabetic ketoacidosis. the hypotheses are: 1. 3-ohb related inhibition of lipolysis is impaired in patients with type 1 diabetes. 2. intravenous infusion of 3-ohb affects signaling pathways involved in the metabolic regulation in patients with type 1 diabetes and healthy controls. 3. 3-ohb infusion improves cardiac function in patients with type 1 diabetes and healthy controls. the effects of 3-ohb will be investigated by isotopic tracers examinations, fat and muscle biopsies and blood samples. to evaluate effects on cardiac function echocardiography will be performed.


Eligibility criteria:
patients with type 1 diabetes: inclusion criteria: * type 1 diabetes diagnosis * c-peptide negative * 19 \< bmi \< 26 * written consent exclusion criteria: * severe comorbidity * regular medication apart from insulin (except over-the-counter medicines) * use of long acting insulin analogues, that work \> 24 hours, e.g. tresiba * pi finds the patient not fit (e.g. mental illness, too nervous, unacceptable screening blood tests or other). healthy control subjects: inclusion criteria: * 19 \< bmi \< 26 * written consent exclusion criteria: * chronic disease * regular medication (except over-the-counter medicines) * pi finds the patient not fit (e.g. mental illness, too nervous, unacceptable screening blood tests or other).