Kornimate/medical-research-clean huggingface dataset:
the effect of different intraradicular cryotherapy on post-operative pain and the level of substance p

Conditions: Post Operative Pain; Inflammation

Summary: the aim of this clinical trial is to evaluate the effect of using intra-radicular cryotherapy technique in the form of irrigation with cold sodium hypochlorite the main questions to answer are: 1. does postoperative pain is different between the three groups? 2. does level of substance p different between the three groups ?

* the patients will be randomly divided into three groups group 1: control group (n=25) regular root canal treatment with regular irrigant will be used. group 2: (n=25) intraradicular cryotherapy will be performed where : * normal root canal treatment will be done with irrigation using sodium hypochlorite cooled to 2°c continuously during our mechanical instrumentation. then a final flush will be done with cold saline 2°c for 5 minutes. group 3: (n=25) normal root canal treatment will be done with irrigation using sodium hypochlorite at room temperature during our mechanical instrumentation. then a final flush will be done with cold saline 2°c for 5 minutes.

Eligibility criteria:
inclusion criteria: * patients that will be diagnosed with symptomatic apical periodontitis * single-rooted premolars (radiographically and clinically assessed) * medically free patients. * teeth with mature apex exclusion criteria: * patients with other pulpal diagnosis. * medically compromised patients. * pregnant females. * patients taking analgesics or anti-inflammatory drugs.

Keywords: cryotherapy substance p apical periodontitis post operative pain
interest of virtual reality on anxiety before the planning ct scan in radiotherapy

Conditions: Breast Cancer; Pelvic Cancer

Summary: in france, according to the national cancer institute, it appears that treatments in radiotherapy centers for cancer will increase from 198,000 in 2015 to 239,000 in 2030: this represents 40,000 additional treatments in 15 years. a meta-analysis on radiotherapy indicated that 10 to 20% of patients had clinically significant levels of anxiety at the beginning of radiotherapy. indeed, several factors generate this tension, above all the new or unfamiliar environment, the imposing and noisy scanner, the restraints that are difficult to bear or the nudity required for the examination. this anxiety has an impact on performance of the planning ct scan examination, an essential step for the future treatment. the radiotherapy unit of the centre hospitalier departemental de vendee has put in place resources to reduce anxiety felt during treatment sessions (music therapy, conversational hypnosis, sophrology or aromatherapy). however, nothing has been put in place to reduce the anxiety of patients in the period preceding the planning ct scan. virtual reality software seems to be a good alternative that requires fewer human resources. the research hypothesis is that patients who have benefited from the virtual reality software will have a lower level of anxiety before the planning ct scan than patients who have not benefited from virtual reality.


Eligibility criteria:
inclusion criteria: 1. patient with an indication for first radiotherapy treatment for breast or pelvic cancer (prostate, rectum, endometrium, anal canal and cervix) 2. patient ≥ 18 years old, 3. patient who has the capacity to understand the protocol and has given written consent to participate in the research, 4. patient with social security coverage. exclusion criteria: 1. metastatic patients 2. patients with previous radiotherapy 3. patients with a diagnosis of hearing impairment 4. patients with major cognitive disorders (such as dementia) 5. psychiatric pathology such as schizophrenia 6. patients with epilepsy or hypersensitivity to flashing lights 7. patient with a pacemaker, hearing aid or defibrillator 8. claustrophobic patients 9. patients sensitive to motion sickness 10. patients who are visually impaired or blind 11. patients with migraine 12. patients with skin defects and open wounds in the area where the helmet is applied (face or scalp) or in the eyes 13. patients under guardianship, curators or deprived of liberty 14. non french speaking patient 15. illiterate patient 16. patient participating in another clinical investigation or interventional clinical research protocol involving a drug 17. pregnant or breastfeeding patient
growth hormone and endothelial function in children

Conditions: Growth Hormone Deficiency; Panhypopituitarism; Short Stature

Summary: objective: this study is designed to determine whether growth hormone treatment in children 8 to 18 years of age alters function of the lining of the arteries. this may play a role in increasing or decreasing the risk of heart disease. methods. twenty children, for whom growth hormone therapy will be otherwise provided, will be studied before and 3 months after starting growth hormone. subjects can be on other hormonal replacements but no other medications. each study will be done in the fasting state. the blood vessel function will be determined by measuring the change in forearm blood flow before and after blocking flow to the arm for 5 minutes. blood will be drawn after the test to measure glucose, insulin and fats.

the purpose of the research is to learn more about how the lining of arteries in the body (called the endothelium) is affected by growth hormone treatment in children and adolescents. poor function by the blood vessels is associated with increased risk of heart disease or stroke. this research is being done because growth hormone treatment has been shown to make the endothelium work better in adults. growth hormone treatment may have the same or different effects in children because the dose is larger in children. children between 8 and 18 years who are to be started on growth hormone will be eligible to participate. blood vessel function will be studied before starting growth hormone and 3 months after. this will be done by measuring blood flow to the arm before and after 5 min of stopping blood flow to the arm. the three months of growth hormone will be given free.

Eligibility criteria:
inclusion criteria: * isolated growth hormone deficiency (peak growth hormone level less than 10 ng/ml in response to arginine-insulin stimulation with cortisol responses and thyroid function tests), panhypopituitarism with appropriate thyroxine (normal free t4 level) and cortisol replacement (8-12 mg/m2/day) and non classic growth hormone deficiency (growth velocity less than 5 cm/year; peak growth hormone \>10 ng/ml). exclusion criteria: * taking medications other than the appropriate hormonal replacement(l-thyroxine, cortisol, estrogen or testosterone, ddavp)

Keywords: growth hormone endothelial function
impact of opportunistic salpingectomy on ovarian reserve in patients undergoing laparoscopic hysterectomy

Conditions: Benign Uterine Disease

Summary: recently, many gynecologic oncologists proposed that surgeons should consider opportunistic salpingectomy to prevent ovarian cancer for all patients undergoing hysterectomy for benign disease. however, the safety and the consequences regarding ovarian function after salpingectomy have not yet to be established. therefore, the aim of this randomized controlled study is compare the ovarian reserve via anti-müllerian hormone (amh) between laparoscopic hysterectomy (lh) alone and lh combined with salpingectomy.


Eligibility criteria:
inclusion criteria: * women who were planning to undergo laparoscopic hysterectomy for benign uterine diseases * women aged between 19 and 52 years * women with regular menstruation (defined as the duration of menstrual cycle between 21 and 45 days) * women who were appropriated medical status for laparoscopic surgery exclusion criteria: * any ovarian cysts requiring ovarian surgery * any suspicious findings of malignant diseases * history of prior salpingectomy or salpingo-oophorectomy * pregnant or menopausal status * preoperative serum anti-müllerian hormone (amh) \< 0.30 ng/ml * use of hormonal treatments in the three months before surgery * any other endocrine disease (such as uncontrolled thyroid dysfunction, hyperprolactinemia, or cushing syndrome) * an inability to understand and provide written informed consent.
human amniotic membrane and mesenchymal stem cells composite

Conditions: Brachial Plexus Neuropathies

Summary: the purpose of this clinical trial is to investigate the utility of composite wrapping comprising human amniotic membrane and allogeneic adipose-derived mesenchymal stem cells (ham-admsc) for augmentation of nerve transfer procedure in upper tbpi patients

nerve transfer procedure is recognized as the current gold standard for treating traumatic brachial plexus injury (tbpi). however, despite the current major progress in diagnosis and microsurgical repair, the prognosis in tbpi remains unfavorable due to limited donor nerve and compromised regenerative capability of the nervous system arising from prolonged denervation. therefore, there is a major need to devise new treatment strategies; and one possible approach is to develop cellular therapies to bioengineer new nerve tissue and/or modulate the endogenous regenerative mechanisms within the injured nerve. our previous studies have shown that the peripheral nerve tissue engineering approach using human amniotic membrane seeded with allogeneic adipose-derived mscs to augment axonal regeneration in nerve transfer of tbpi patient revealed promising functional recovery of the shoulder range of motion (rom). the investigators plan a non-randomized clinical trial in a single center to investigate the use of a hybrid (composite) between human amniotic membrane (ham) and allogeneic adipose-derived mesenchymal stem cells (admsc) as wrapping in the nerve transfer procedure of upper tbpi patients, with a focus on the augmentation of axonal regeneration

Eligibility criteria:
inclusion criteria: * suffering from upper bpi (c5-c6 and/or c5-c7) for a duration of fewer than 12 months * have no systemic disease (diabetes mellitus, lupus erythematosus, rheumatoid arthritis) * without prior medicamentous treatment history such as corticosteroids * agree to contribute in the study exclusion criteria: * complete bpi (c5-th1), lower bpi (c8-th1) * traumatic bpi associated with delayed/non-union fracture of the upper extremity affected side. * polytrauma conditions which are not fully recovered

Keywords: brachial plexus injury amniotic membrane mesenchymal stem cells nerve transfer
new cross-linked hyaluronan gel to prevent adhesion after usg-mva: rct

Conditions: First Trimester Abortion; Surgical Abortion; Miscarriage With Afibrinogenemia

Summary: the objective of this prospective, randomized controlled study was to evaluate the effectiveness of this nch gel in the prevention of iua development as assessed by hysteroscopy after usg-mva, in the treatment for first-trimester miscarriage. * to study the severity and extent of the iua as assessed by the afs and esge adhesion score in both groups of patients. * to examine the rate of complications or side effects with the nch gel. * to assess the subsequent menstrual history and reproductive outcome in both groups of patients.

there is limited data to evaluate the incidence of iua after using this nch gel in patients undergoing surgical evacuation via usg-mva for the treatment of first-trimester miscarriage. previous rct showed a significant reduction in iua with the use of nch gel, with iua detected in only 9.5% of patients with nch gel applied compared to 24.1% in the control group. however, the group did not involve patients undergoing surgical evacuation by usg-mva. therefore, the objective of this prospective, randomized controlled study was to evaluate the effectiveness of this nch gel in the prevention of iua development as assessed by hysteroscopy after usg-mva, in the treatment of first-trimester miscarriage.

Eligibility criteria:
inclusion criteria: * women 18 years old or above * no previous history of iua/ asherman's syndrome * no previous surgical history of eva or dilatation or curettage or surgical termination of pregnancy or caesarean section * no previous history of therapeutic hysteroscopic surgeries * voluntary informed consent and understanding of study exclusion criteria: * previous therapeutic hysteroscopic procedures (e.g. endometrial ablation, removal of fibroids or polyps, surgical correction of congenital uterine anomalies or adhesiolysis) * suspicion of molar pregnancy * genital tract malformation * suspicion of active infection or genital tract malignancy or genital tuberculosis * abnormal blood coagulation * inability to tolerate pelvic examination known * suspected intolerance of hypersensitivity to nch gel or its derivatives * patient refusal

Keywords: first trimester abortion surgical abortion intrauterine adhesion hyaluronan gel protective agents hyaluronic acid manual vacuum aspiration miscarriage
effects of online pilates and face-to-face pilates on healthy individuals

Conditions: Healthy Lifestyle; Health Behavior

Summary: many studies on pilates have shown that these exercises positively affect the endurance of core muscles, mental health, and quality of life in healthy individuals when applied face-to-face. in a few recent studies, the effects of online pilates training have been examined and shown to be effective on core endurance, depression, and quality of life. in the results of these studies, it has been emphasized that it is necessary to compare whether online pilates training is as practical as face-to-face pilates training. for this reason, the investigators thought that randomized controlled studies investigating the effects of online and face-to-face pilates methods in healthy individuals are needed. the investigators planned a randomized controlled study investigating the impact of online pilates and face-to-face pilates methods. the study aims to examine and compare the effects of online pilates and face-to-face pilates methods on core muscle endurance, depression, and quality of life in healthy individuals.

an experienced physiotherapist blind will evaluate participants by randomization at the start of the study and eight weeks later. the group participants belong to will not be disclosed to the participants until the end of the first assessment. individuals who complete the initial evaluation will be randomly assigned to the online pilates group (opg) or face-to-face pilates group (fpg) using a computer program. both online and face-to-face applications will be carried out under the supervision of a physiotherapist with 11 years of experience. participants included in the study will be evaluated with data collection forms filled twice, before and after the training programs. the participants' demographic information (age, body weight, height, body mass index) will be recorded. statistical analysis will be performed using spss software, version 21 (spss inc. chicago, il, usa). the normal distribution of the variables will be determined using histograms, probability plots, and the shapiro-wilk test. due to the abnormal distribution, the median and interquartile range (iqr) will be used for descriptive statistics. a mann-whitney u test will be used to compare baseline and vary values between groups. the wilcoxon test will compare baseline values within the group to values after six weeks. the significance level will be set-top \< 0.05 for all analyses. effect sizes will be evaluated according to cohen's d standards within pre-post differences. effect size results will be interpreted as small (≥ 0.2), moderate (≥ 0.5), or large (≥ 0.8) according to the guidelines.

Eligibility criteria:
inclusion criteria: * 25-40 years of age. * voluntarily participate in research to accept exclusion criteria: * any cardiovascular, orthopedic, visual, hearing, and perception problems that may affect the results of the research. * participating in other exercises or physiotherapy programs during the past 6 months.

Keywords: online pilates quality of life depression core pilates exercises
the immediate effects of intermittent theta burst stimulation on intracortical excitability of the primary motor cortex in patients with chronic stroke

Conditions: Stroke

Summary: this study is to investigate the immediate effects of intermittent theta burst stimulation (itbs) on intracortical excitatory and inhibitory circuits, neural connectivity, and network properties in patients with chronic stroke, using transcranial magnetic stimulation and electroencephalogram (tms-eeg) and tms-electromyography (emg) and approaches.

the neurophysiological effect of intermittent theta burst stimulation (itbs) has been examined with tms-electromyography (emg)-based outcomes in healthy people; however, its effects in intracortical excitability and inhibition are largely unknown in patients with stroke. concurrent transcranial magnetic stimulation and electroencephalogram (tms-eeg) recording can be used to investigate both intracortical excitatory and inhibitory circuits of the primary motor cortex (m1) and the property of brain networks. this study is to investigate the immediate effects of itbs on intracortical excitatory and inhibitory circuits, neural connectivity, and network properties in patients with chronic stroke, using tms-eeg and tms-emg approaches. in this randomized, sham-controlled, crossover study, 21 patients with chronic stroke receive two separate stimulation conditions: a single-session itbs or sham stimulation applied to the ipsilesional m1, in two separate visits, with a washout period of five to seven days between the two visits after crossover. a battery of tms-emg and tms-eeg measurements are taken before and immediately after stimulation during the visit.

Eligibility criteria:
inclusion criteria: 1. suffered from first-ever, ischemic or hemorrhagic, unilateral stroke, verified by neuroimaging examinations such as ct or mri. 2. detectable motor evoked potentials from the affected first dorsal interosseous muscle; 3. provided written informed consent. exclusion criteria: 1. had any contraindication to transcranial magnetic stimulation; 2. had a known neurological disease excluding stroke, or psychiatric disease; 3. were using a psychostimulant, sedative, antidepressant, or antiepileptic medication.

Keywords: stroke theta burst stimulation transcranial magnetic stimulation-evoked potentials intracortical inhibition cortical excitability
karydakis procedure vs limberg flap in treatment of sacrococcygeal pilonidal sinus

Conditions: Pilonidal Sinus

Summary: this study will be a randomized controlled trial in which there will be comparison of the effectiveness of karydakis procedure and limberg flap in treatment of sacrococcygeal pilonidal sinus


Eligibility criteria:
inclusion criteria: * patients with pilonidal sinus of any sex and aged 20 years or above * non infected pilonidal sinus exclusion criteria: * infected pilonidal sinus * uncontrolled diabetes * patient on immunosuppressive therapy
the effect of sarpogrelate and high dose statin on the reduction of coronary spasm

Conditions: Variant Angina

Summary: the aim of the study was to to evaluate the effect of sarpogrelate, a selective serotonin receptor antagonist, and high dose statin on the reduction of coronary spasm in the patients with variant angina.


Eligibility criteria:
inclusion criteria: * clinical history of chest pain compatible with variant angina; morning chest pain aggravated by cold exposure. * angiographically proven coronary spasm; timi flow \< 3 by spontaneous coronary spasm or intracoronary ergonovine spasm provocation test. exclusion criteria: * cardiac arrest by coronary spasm * left main coronary spasm * significant fixed coronary artery stenosis; diameter stenosis \> 70% in the major epicardial artery by coronary angiography * left ventricular ejection fraction \< 30% * coagulation disorders or bleeding tendency (platelet count \ 2.0) * significant liver disease (ast or alt \> 100 u/ml) * renal failure (s-cr \> 2.0 mg/dl) * hypersensitivity for statin * pregnancy

Keywords: vasospasm sarpogrelate statin
effect of ergonomic classroom furniture on the printing legibility of elementary students with cerebral palsy

Conditions: Cerebral Palsy

Summary: the purpose of this pilot study is to gather the data needed to do a larger research study to determine whether children with cerebral palsy print better sitting at an ergonomically-designed, custom-fitted school desk or at an oversized, standard school desk.

this pilot study will allow us to gather information for a high-quality randomized controlled trial to study the efficacy of ergonomic school furniture as a remedial handwriting intervention for young students with cerebral palsy. we will conduct the study in two parts. in the first part, 30 children with gross motor function classification system (gmfcs) level i and ii cerebral palsy will each provide manuscript handwriting samples using two different school furniture configurations. a blinded assessor will score the legibility of handwriting samples using the minnesota handwriting assessment (mha) as a primary outcome measure. in the second part, seven occupational therapy experts will attend a focus group to help us determine the minimal clinically important difference score for the mha. we will use the data collected to determine the sample size requirements for a proposed randomized controlled trial.

Eligibility criteria:
inclusion criteria: * primary diagnosis of cerebral palsy * functional status of gross motor function classification system level i or ii exclusion criteria: * genetic disorder; * attention-deficit hyperactivity disorder; or, * pervasive developmental disorder

Keywords: handwriting child primary school posture assistive device
histological outcome of the use of different biomaterials for fresh socket regeneration. a split-mouth design

Conditions: Alveolar Bone Loss

Summary: purpose: the aim of this study was to analyze the quality of bone regeneration in fresh sockets using four different materials and at different times points. materials and methods: a split-mouth clinical trial was designed to evaluate the histological and histomorphometrical characteristics of fresh sockets from 30 patients. one socket per patient will healed spontaneously (control) and, at least, one fresh socket, will be grafted with platelet-rich growth factor (prgf), prgf+autologous bone, autologous bone or prgf+demineralized freeze dried bone allograft (dfdba). the day of the implant placement, biopsies will be taken at different time points divided into three assessment groups: short duration (2-4 months), intermediate duration (5-6 months) and long duration (7-12 months). the histologic findings will be assessed to quantify the trabeculae pattern, the degree of mineralization and the quality of bone regeneration.


Eligibility criteria:
inclusion criteria: * patients in need of at least one bilateral tooth extraction due to one or more of the following causes: * periodontal disease, * vertical fracture * included teeth. * patients seeking dental implant to replace their missing teeth. * all sockets should have intact or partially conserved buccal wall according to elian´s classification (type i, ii). exclusion criteria: * patients under 18 years old. * patients with a severely untreated periodontal disease. * smokers of more than 15 cigarettes a day. * patients suffering from any systemic disease requiring pharmacological treatment. * patients whose socket´s buccal wall is totally missing after tooth extraction