Kornimate/medical-research-clean huggingface dataset:
efficacy study of the non-pneumatic anti-shock garment (nasg) in egypt

Conditions: Hypovolemic Shock; Hemorrhage

Summary: this study will test the efficacy of the nasg on women suffering from obstetric hemorrhage as compared to hemorrhaging women who do not receive the nasg.

this is a comparative, pre-post study of the non-pneumatic anti-shock garment (nasg) to establish its effectiveness in reducing maternal mortality and morbidity due to obstetrical hemorrhage. the sites are two maternity teaching hospitals in egypt: el galaa, in cairo and assiut university in assiut. our main aim was to test the efficacy of the nasg on women suffering from obstetric hemorrhage as compared to hemorrhaging women who do not receive the nasg. our primary outcome was extreme adverse outcomes (eao) - a combined outcome of maternal mortality and severe morbidity. secondary outcomes included mean measured blood loss and incidence of emergency hysterectomy.

Eligibility criteria:
inclusion criteria: * blood loss from obstetric hemorrhage \>= 1000 ml * pulse \> 100 beats per minute or systolic blood pressure \< 100 mmhg exclusion criteria: absolute exclusion criteria: * current viable third trimester intrauterine pregnancy that can be delivered in the next 20 minutes after hemorrhage begins * current bleeding sites above the diaphragm. relative exclusion criteria: * history or current clinical evidence of mitral stenosis or congestive heart failure (chf)

Keywords: maternal mortality obstetric hemorrhage
study of pulmonary artery banding for the improvement of left ventricular function in pediatric heart failure

Conditions: Heart Failure Congenital

Summary: the goal of this observational study is to learn about the safety and effectiveness of pulmonary artery banding(pab) therapy in pediatric heart failure(phf) patients. the main questions it aims to answer are: * can pab therapy improve left ventricular(lv) function in phf patients especially refractory phf. * can the complications caused by the pab therapy be clinically acceptable? participants underwent pab therapy will be required to underwent echocardiography, electrocardiograms, complete blood counts, biochemical tests, and measurements of n-terminal pro-brain natriuretic peptide (nt-probnp) follow-up before the initiation of pab and at 1 month, 3 months, and 6 months after pab surgery. researchers will compare the lv function 6 months after pab suergey and the preoperative ones to see if there is improvement.


Eligibility criteria:
inclusion criteria: * patients younger than 14 years of age * congenital heart failure (lvef\<55%, or lvfs\<25%) exclusion criteria: * single ventricle * congenital heart disease without anatomical correction * patients with heart failure requiring ventricular assist or cardiac synchronization therapy * patients with severe pulmonary hypertension (pulmonary arterial pressure \>6 wood·u) * patients with severe liver and kidney failure * patients who are allergic to related medications * patients with symptomatic hypotension who cannot tolerate related drugs * refuse to sign the informed consent or refuse to participate in this experiment

Keywords: congenital heart disease pulmonary artery banding
impact of bronchial drainage technique by the medical device simeox® on respiratory function and symptoms in adult patients with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: the main objective of the study is to evaluate the short-term effects of the airway clearance technique by the medical device simeox (physio assist, france) versus autogenic drainage, on the pulmonary function of adult patients with stable cystic fibrosis. to analyse these effects, the investigators used forced oscillation technique measured by tremoflo™ c-100 airwave oscillometry system™ (thorasys thoracic medical systems inc. montreal, quebec, canada) with an evaluation of the perceived clinical benefits.


Eligibility criteria:
inclusion criteria: * diagnosis of cystic fibrosis confirmed * age ≥18 years * 30% \<fev1 \<70% predicted * presence of bronchial congestion reported by the patient or the investigator exclusion criteria: * uncontrolled asthma * pneumothorax \<6 weeks * recent severe hemoptysis \<6 weeks * patient registered on the transplant list * exacerbation within 4 weeks (3 months if hospitalization) before screening * cardiovascular disorders, electrocardiogram (ecg) parameters or clinically significant respiratory (non-cystic fibrosis) conditions * patients unable to perform measurements of rof, spirometry, plethysmography. * any contraindication to manual or instrumental physiotherapy. * pregnancy, breastfeeding. * patient under tutorship or curatorship * no affiliation to the french social security * patient using simeox at home * patient under trikafta for less than 6 weeks. * patient using simeox more than twice a week during physiotherapy sessions, not wanting a washout period of 7 days before inclusion

Keywords: cystic fibrosis physiotherapy drainage
comparison of robotic versus laparoscopic surgery for visceral obesity in mid-low rectal cancer: a propensity-matched analysis

Conditions: Visceral Obesity; Rectal Cancer; Robotic Surgery

Summary: our team has previously published articles providing detailed descriptions of the steps involved in both rs and ls. all surgeries adhered to the total mesorectal excision (tme) principle. in rs, a surgeon employed the da vinci xi surgical system featuring a five-port setup, while five physicians conducted ls with a similarly configured five-port approach. both the rs and ls doctors are experienced. the surgeries were conducted according to standard procedures, and the rs group utilized totally robotic rectal resection.


Eligibility criteria:
inclusion criteria: (1) confirmed pathology of mid-to-low rectal cancer (within 10 centimeters from the anal margin); (2) availability of comprehensive pathological and computed tomography (ct) data; (3) presence of a diagnosis indicating visceral obesity. exclusion criteria: multiple tumor
technology assisted stepped collaborative care intervention

Conditions: End-Stage Renal Disease; Hemodialysis

Summary: this study evaluates a collaborative care intervention in reducing depression, fatigue and pain symptoms and improving health related quality of life in hemodialysis patients. half of participants will receive the collaborative care intervention, while the other half will receive technology delivered health education information.

end-stage renal disease patients on hemodialysis experience substantial symptom burden with fatigue, pain and depression among the most debilitating and existing as symptom clusters. these symptom clusters can exacerbate one another, and are independent and strong predictors of poor health-related quality of life in hemodialysis patients. this study will look at the effect of a 12 week stepped care intervention on changes in depression, pain or fatigue and health related quality of life.

Eligibility criteria:
inclusion criteria: 1. 18 years or older 2. undergoing thrice-weekly maintenance hemodialysis for \> 3 months 3. english speaking 4. able to provide informed consent 5. no evidence of thought disorder, delusions or active suicidal ideation exclusion criteria: 1. thought disorder, delusions or active suicidal ideation 2. active substance abuse 3. too ill or cognitively impaired to participate based on clinicians' judgment 4. anticipated life expectancy of less than 1 year 5. unable or unwilling to adhere to study protocol 6. participating in another clinical trial or taking an investigational drug 7. scheduled for living donor kidney transplant within next 6 months 8. relocating to another dialysis unit within 6 months
muscle fatigue and foot biomechanics

Conditions: Foot, Flat

Summary: medial longitudinal arch (mla) is a curve of the foot located at the medial side of the body and protection of the height of the mla is an important factor for limb health. this study was planned with the aim of investigating the response of the mla height to the repetitive muscle activity and determine the gender-related differences.


Eligibility criteria:
inclusion criteria: * healthy young females and males who want to participate to the study exclusion criteria: * have orthopedic, physiologic, psychiatric, neurologic or systemic disorders * have present medication

Keywords: medial longitudinal arch foot
a study of vaginal microflora and immune profiles of patients with recurrent urinary tract infection

Conditions: Urinary Tract Infections

Summary: the purpose of this study is to determine the extent to which vaginal microflora and immune profiles of patients with urinary tract infection (uti) differ from healthy controls.

recurrent urinary tract infections, which occur mostly in the female population, can be potentially harmful if not treated and significantly reduce quality of life. by characterizing the vaginal microflora and immune profiles of women that suffer recurrent utis in contrast to a healthy age matched normal group of women (with no history of recurrent utis), we can better understand the differences. this in turn can lead to development of better quality probiotics that will be based on their scientific basis, clinical efficacy, and quality in terms of shelf life and delivery to target sites. the reduction in only one third of uti cases seen each year would have a significant impact on reducing health care costs.

Eligibility criteria:
inclusion criteria: inclusion criteria for uti group: 1. at least 2 recurrent utis within the last year 2. written informed consent inclusion criteria for normal group: 1. no uti within the past 5 years 2. written informed consent exclusion criteria: exclusion criteria for both groups: 1. active uti 2. urinary tract anomalies 3. evidence of a neurogenic bladder 4. known immunodeficiencies 5. use of antibiotics, within the last month 6. concomitant use of oral steroids 7. known renal calculi 8. previous or ongoing chemotherapy 9. pregnancy
prebiotic fiber as a modifier of satiety hormones and body weight in overweight and obese adults

Conditions: Obesity

Summary: the purpose of this study is to determine if oligofructose supplementation promotes weight loss in overweight and obese adults.

obesity is a primary health concern for many western countries as it is linked to several chronic diseases as well as, large health care costs. although obesity is a multifactorial disease, it is known that levels of satiety hormones including glucagon like peptide-1 (glp-1) and peptide yy (pyy) are reduced in obesity. the ability of prebiotic fiber to promote weight loss through the production of satiety hormones has been tested previously using rodents. here it was found that prebiotic supplementation resulted in a decreased energy intake, higher glp-1 levels in the plasma and increased proglucagon mrna levels in the gut. this study will address the important question of whether prebiotic fiber supplementation is effective in reducing body weight in overweight or obese human subjects.

Eligibility criteria:
inclusion criteria: * overweight or class i obese individuals with bmi between 25 kg/m2 and 34.9 kg/m2 * stable body weight in previous 3 months exclusion criteria: * type 1 and type 2 diabetes * clinically significant cardiovascular abnormalities * liver or pancreas disease * major gastrointestinal surgeries * are pregnant or lactating * exhibit alcohol or drug dependence * on drugs influencing appetite * are following a diet or exercise regime designed for weight loss * have a body mass greater than 350lb * chronic use of antacids or bulk laxatives

Keywords: obesity weight loss satiety hormones body composition appetite ratings
combination of hemodialysis with hemoperfusion：a clinical study

Conditions: Renal Dialysis; Hemoperfusion; Quality of Life

Summary: this study is a prospective, randomized, controlled multicenter clinical study. the aim of the study is to investigate whether the combination of maintenance hemodialysis (mhd) with hemoperfusion (hp) could improve the clearance rate of middle and large molecule uremic toxins so as to improve the quality of life of mhd patients and reduce their mortality rate.


Eligibility criteria:
inclusion criteria: 1. age≥18, male or female 2. maintenance hemodialysis duration\>3 months 3. regular hemodialysis,3 times a week,4 hours per session 4. vascular access unlimited 5. ipth≥300pg/ml 6. sign the written informed consent exclusion criteria: 1. allergic to dialysis equipment 2. plt\<60×10\^9/l 3. blood flow\<200ml/min 4. serum albumin\<30g/l 5. kt/v\<1.2 6. ipth\>800pg/ml 7. hemodiafiltration 8. coagulation disorder, severe bleeding tendency, with active bleeding 9. severe hypotension, severe cardiopulmonary insufficiency 10. under other drug trial 11. acute infection, severe heart, lung, liver, nervous diseases, malignant tumor

Keywords: hemodialysis hemoperfusion quality of life
assessment of novel measurement and fitting methods to determine their reliability, validity and application - sonova2018_34

Conditions: Hearing Loss

Summary: a methodical evaluation of novel measurement and fitting methods for individualizing ce-labelled sonova brand hearing instruments (e.g. phonak hearing instruments) is intended to be conducted on hearing impaired participants. the aim of the study is to investigate and asses strength and weaknesses of these novel measurement and fitting methods in terms of optimizing hearing performance and experience and/or usability of the hearing aids and accessories. both laboratory measurements as well as evaluations in real life environments will be carried out. this will be a controlled and randomised active comparator clinical evaluation which will be conducted mono-centric at sonova ag headquarter based in stäfa.


Eligibility criteria:
participants fulfilling all of the following inclusion criteria are eligible for the study: * adult hearing impaired persons (minimum age: 18 years) with and without (experience with) hearing aids * healthy outer ear (without previous surgical procedures) * ability to fill in a questionnaire (p/ecrf) conscientiously * informed consent as documented by signature the presence of any one of the following exclusion criteria will lead to exclusion of the participant: * contraindications to the md in this study, e.g. known hypersensitivity or allergy to the investigational product * limited mobility and not in the position to attend appointments * limited ability to describe listening impressions or to use hearing aids/ accessories * inability to produce a reliable hearing test result * massively limited dexterity * known psychological problems * known central hearing disorders
screening for the implantation of a subcutaneous implantable automatic defibrillator

Conditions: Sudden Cardiac Death; Implantable Defibrillator

Summary: s-icd (subcutaneous implantable cardioverter-defibrillator) screening failure occurs in about 10% of cases. predictors of screening failure are not yet well determined. moreover, slight variations in electrode positioning may change vector configuration and therefore improve screening success rates

s-icd (subcutaneous implantable cardioverter-defibrillator) has become the last years widespread in various pathological conditions and implantation rates are increasing each year worldwide. previous to implantation it is mandatory to realize a screening in order to assess specific electrocardiographic vectors used to analyze cardiac rhythm. in routine practice, approximatively 10% of patients are recused for s-icd device implantation due to failed screening 1-3. causes are mainly abnormalities of r wave (low or high amplitude) and low r/t wave ratio. determinants for screening failure have not yet been clearly studied. moreover, it is a common finding in s-icd implantation to find variations between pre-implant electrograms and electrograms recorded by the device. variations of r wave amplitude and r/t ration are also observed with small variations of electrode positioning prior to implantation. it has been also shown that despite initial screening failure, s-icd could be securely performed in some cases 4,5. patients included in the study will undergo usual screening protocol. in case of failure a 2nd screening will be realize with slight electrode positioning variations compatible with s-icd and lead placement. in case of success modality of implantation will be decided by physician. in case of s-icd implantation screening data will be compared to post implantation device electrograms. a 2 month follow-up will be performed with comparison of a new screening procedure with electrodes at the level of sub-cutaneous electrodes.

Eligibility criteria:
inclusion criteria: * the population will be composed of all patients referred for icd method, aged over 18 years exclusion criteria: * age \< 18 years old * patients who cannot freely give their consent, or patients who refuse to participate
extracorporeal shock wave lithotriptor indicated for fragmenting urinary stones in the kidney

Conditions: Kidney Stones

Summary: a total of 20 subjects presenting with urinary stone(s) in the kidney or ureter will be treated with an extracorporeal shockwave lithotripsy device to fragment the stones. subjects will be followed for 14 days. if at the 14 day follow-up visit the subject continues to present with a stone size 4 mm or greater will have an option of retreatment or other intervention. if the subject consents to be retreated at this time, this subject will be followed up for another 14 days.


Eligibility criteria:
inclusion criteria: * diagnosis of a solitary urinary stones in the renal pelvis or renal calyces or ureter * presence of one stone greater than 4 mm and less than 12 mm exclusion criteria: * urinary tract obstruction, acute or unresolved cholecystitis, cholangitis, pancreatitis or obstruction of the biliary duct system * impaction of stone to be treated * staghorn stones * failed or inadequate lithotripsy procedure within 3 months prior to study * coagulation abnormalities or anticoagulation therapy * pregnant or females of child-bearing potential general, spinal or epidural anesthesia is contraindicated * can not be positioned correctly for fluoroscopic imaging

Keywords: fragmenting of kidney stones extracorporeal shockwave lithotripsy
cardiovascular events among adults patients with relapsed or refractory aggressive b-cell lymphoma treated with standard of care chimeric antigen receptor t cell therapy

Conditions: Recurrent Aggressive B-Cell Non-Hodgkin Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent High Grade B-Cell Lymphoma; Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma; Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma; Refractory Aggressive B-Cell Non-Hodgkin Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory High Grade B-Cell Lymphoma; Refractory Primary Mediastinal (Thymic) Large B-Cell Lymphoma; Refractory Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

Summary: this study characterizes cardiac events following standard of care chimeric antigen receptor t cell therapy in patients with aggressive b-cell lymphoma that has come back (relapsed) or does not respond to treatment (refractory). the results from this study may allow a description of these events, their managements and outcome.

primary objective: i. to characterize cardiac events following standard of care (soc) chimeric antigen receptor t (car-t) cell therapy in adult patients with relapsed/refractory aggressive b-cell lymphoma. outline: patients' medical records are reviewed retrospectively.

Eligibility criteria:
inclusion criteria: * adults (\>= 18 years) with a diagnosis of aggressive b-cell lymphoma (such as transformed follicular lymphoma, diffuse large b-cell lymphoma, primary mediastinal b-cell lymphoma and high-grade b-cell lymphoma), who received standard of care (soc) chimeric antigen receptor t (car-t) cell therapy at md anderson cancer center exclusion criteria: * none
acceptation and qualitative evaluation of phone-delivered intervention

Conditions: Suicide

Summary: background: previous suicide attempt is known to be a strong risk factor for repetition and repetition is common within the first year after an episode of deliberate self-harm (dsh). there has been growing interest in brief interventions for this population that are focused on maintaining long-term contact and/or offering re-engagement with services when needed. despite telephone-delivered interventions have shown promising results in suicide reattempt prevention, subjective impact of such brief contact interventions and effectiveness mechanisms have never been evaluated.

semi-structured in-depth interviews with 20 patients previously receiving a telephone-delivered intervention from our team. six weeks and 3 months after a dsh, people included in telephone-delivered process will be interviewed by a social science researcher. qualitative analysis using thematic analysis will be independently performed by two researchers.

Eligibility criteria:
inclusion criteria: * deliberate self-harm in the previous week, * 18 years old and older, * outpatient care orientation after discharge from emergency department exclusion criteria: * difficulties in french language, * mental retardation

Keywords: suicide prevention