Kornimate/medical-research-clean huggingface dataset:
a randomised study comparing tissue conservation in conventional versus mohs' surgery of basal cell carcinoma

Conditions: Carcinoma, Basal Cell

Summary: we have compared to types of surgery to assess which one leaves the smaller surgical defect.

patients with a clinical diagnosis of a nodular basal cell carcinoma of less than 1 centimetre and 1 centimetre away from eyes, nose and ears were either randomized to undergo mohs micrographic surgery or standard surgical excision. after the tumour had been removed the defect was measured.

Eligibility criteria:
inclusion criteria: * subjects with a clinical diagnosis of a nodular basal cell carcinoma of less than 1 cm, 1 cm away from eye, nose or ears exclusion criteria: * subjects of less than 18 years of age * subjects unable to comply with instructions, * immunosuppressed subjects
prophylactic ilioinguinal neurectomy during open tension-free inguinal hernia repair

Conditions: Ilioinguinal Nerve Section; Pain Prevention; Hernioplasty

Summary: postoperative chronic inguinal pain is a common postoperative complication after open inguinal hernia repair. chronic inguinal pain is a common complication following open inguinal hernia repair. ilioinguinal nerve entrapment is a common cause of this chronic pain which may adversely affect the patients' life. ilioinguinal neurectomy seems to be beneficial in preventing such pain, but it carries the risk for numbness and hypoesthesia.


Eligibility criteria:
inclusion criteria: - the study included all adult patients operated on for unilateral inguinal hernia by lichtenstein tension-free mesh hernioplasty with or without ilioinguinal neurectomy. exclusion criteria: * patients with recurrent inguinal hernia, bilateral inguinal hernia repair, or huge inguinoscrotal hernia were excluded. diabetic patients as well as, patients with suspected inguinal hernia recurrence at the time of the questionnaire were excluded.
act with feedback for post traumatic stress disorder (ptsd)

Conditions: PTSD

Summary: the purpose of this study is to explore the efficacy of attention control training with the inclusion of feedback for post traumatic stress disorder (ptsd). it seems that the most efficient abmt method to balance attention bias variability (abv) among individuals with ptsd is attention control training (act). this type of training is designed to balance attention allocation towards threat-related and neutral stimuli. a few studies have further shown that this training type succeeds in balancing the aberrant fluctuations in attention bias observed in patients with ptsd, and that this leads to a reduction in ptsd symptoms (badura-brack et al., 2015). the purpose of the current study is to examine the efficacy of act that also includes feedback. specifically, we intend to test whether the inclusion of feedback on top of standard act may enhance training efficacy in reducing abv and in reducing ptsd symptoms.

the aim of the current study is to explore the efficacy of attention control training with the inclusion of feedback for post traumatic stress disorder (ptsd). individuals with ptsd exhibit increased threat-related attention bias variability (abv; lacoviello et al., 2014; naim et al., 2015). based on these findings, computerized training methods aimed to modify the attention bias were developed (attention bias modification training; abmt). it seems that the most efficient abmt method to balance abv among individuals with ptsd is attention control training (act). this type of training is designed to balance attention allocation towards threat-related and neutral stimuli. a few studies have further shown that this training type succeeds in balancing the aberrant fluctuations in attention bias observed in ptsd, and that this leads to a reduction in ptsd symptoms (badura-brack et al., 2015). the purpose of the current study is to examine the efficacy of act that also includes a feedback component. specifically, we intend to test whether the inclusion of feedback on top of standard act may enhance training efficacy in reducing abv and in reducing ptsd symptoms. for this purpose, we will recruit 60 idf veterans diagnosed with ptsd that will be randomly assigned to one of two conditions: act with feedback or act with yoked sham feedback. we expect that act with feedback will produce greater reduction in ptsd symptoms and in abv relative to act with yoked sham feedback.

Eligibility criteria:
inclusion criteria: * diagnosis of ptsd according to the dsm-5 and related to military service, ages 18-65 exclusion criteria: * psychotic or bipolar disorder, drug and alcohol abuse, other psychological treatment, vision problems that are not overcome with regular glasses, physical disability that prevents ability to operate computer.

Keywords: ptsd attention training cognitive bias modification attention bias modification
evaluating wearable robotic assistance on gait

Conditions: Cerebral Palsy

Summary: the overarching goal of this study is to improve mobility in individuals with movement disorders through advances in wearable assistance (i.e. powered orthoses).

individuals with cerebral palsy completed high frequency over-ground gait training (4x/week for 1 week) with ankle exoskeleton assistance, and then, after a 1 year washout period, the same participants will complete low frequency over-ground gait training (2x/week for 2 weeks).

Eligibility criteria:
inclusion criteria: * age between 5 and 35 years old, inclusive. * either a healthy volunteer or a diagnosis of a neurologically-based walking disorder due to stroke, spinal cord injury, parkinson's disease, or cerebral palsy. * must be able to understand and follow simple directions based on parent report and clinical observation during the history and physical examination. * able to provide verbal assent, if appropriate. if the participant is non-verbal, parental interpretation of gesticulation for assent will be used. * the ability to read and understand english. * able to walk at least 30 feet with or without a walking aid (gmfcs level i-iii for individuals with cerebral palsy) exclusion criteria: • any neurological, musculoskeletal or cardiorespiratory injury, health condition ( including pregnancy), or diagnosis other than stroke, spinal cord injury, parkinson's disease or cerebral palsy that would affect the ability to walk as directed for short periods of time.
sputum cytology in screening heavy smokers for lung cancer

Conditions: Lung Cancer

Summary: rationale: screening tests, such as sputum cytology, may help doctors find tumor cells early and plan better treatment for lung cancer. purpose: this phase ii trial is studying how well sputum cytology works in screening heavy smokers for lung cancer.

objectives: primary * classify annual sputum samples cytologically in participants with or without airflow obstruction and a heavy smoking history. * correlate sputum cytological atypia (moderate atypia or worse) with lung cancer incidence in these participants. * correlate changes in sputum cytology (i.e., changes toward higher grades of atypia) with lung cancer incidence in these participants. secondary * determine other risk factors for lung cancer (e.g., diet, family history, smoking history, and medications) that may either confound or modify the association between sputum cytology and lung cancer risk in these participants. outline: two 3-day pooled sputum samples are collected for 6 consecutive days from participants by the spontaneous cough technique for cytopathological evaluation. participants also complete a risk factor questionnaire and undergo a pulmonary function test by spirometry and a blood draw. participants complete a questionnaire updating smoking, vital, and lung cancer status and undergo sputum sample collection annually. participants are informed of sputum cytology results. projected accrual: a total of 3,400 participants (2,900 with airflow obstruction and 500 without airflow obstruction) will be accrued for this study.

Eligibility criteria:
disease characteristics: * current or ex-smoker with a lifetime history of cigarette smoking of ≥ 20 pack years, meeting 1 of the following criteria: * airflow obstruction * fev_1 \< 75% predicted for age by spirometry * fev_1/fvc ≤ 75% by spirometry * no airflow obstruction * no history of lung cancer patient characteristics: age * 25 and over performance status * not specified life expectancy * more than 5 years hematopoietic * not specified hepatic * not specified renal * not specified other * no cancer within the past 5 years except nonmelanoma skin cancer prior concurrent therapy: biologic therapy * not specified chemotherapy * not specified endocrine therapy * not specified radiotherapy * not specified surgery * not specified

Keywords: non-small cell lung cancer small cell lung cancer
antenatal allopurinol in intrauterine growth restriction

Conditions: Fetal Growth Retardation

Summary: growth retardation in utero may be caused by uteroplacental vascular insufficiency. when doppler ultrasound studies of the umbilical artery are abnormal pathological intrauterine growth restriction (iugr) can be diagnosed. iugr fetuses have a higher mortality and morbidity, both perinatally and on the longer term. this is probably due to chronic malnourishment and hypoxia due to placental insufficiency. this placental dysfunction causes generation of harmful free oxygen radicals in the fetus. the iugr fetus has a diminished antioxidative capacity which means these free radicals cannot be buffered sufficiently. this leads to fetal oxidative stress. previous studies have shown that allopurinol can inhibit the cascades that lead to generation of free radicals. high dosed allopurinol also scavenges radicals and binds free iron without adverse effects on the fetus or mother. as iugr is associated with placental insufficiency and excessive production of free radicals we hypothesize that antenatal allopurinol administration could lead to a decrease in oxidative stress in the mother and fetus and subsequent improvement of the maternal and/or neonatal outcome.


Eligibility criteria:
inclusion criteria: mothers with a gestational age (ga) of 30 to 36 weeks with: * foetal growth retardation (growth \<10th percentile) and * abnormal doppler flow in the umbilical cord (umbilical artery pulsatility index (pi)\>95th percentile) exclusion criteria: * congenital, chromosomal or syndromal abnormalities * positive screening for intrauterine viral infections * mothers with gout and high uric acid * creatinine \> 100 umol/l * asat \> 80 u/l, alat \> 80 u/l * uric acid \> 0,50 mmol/l

Keywords: allopurinol fetal growth retardation oxidative stress placental insufficiency
tocolysis in the management of preterm premature rupture of membranes before 34 weeks of gestation

Conditions: Preterm Premature Rupture of Membrane

Summary: the purpose of this study is to assess whether short-term (48 hr) tocolysis reduces perinatal morti-morbidity in cases of pprom at 22 to 33 completed weeks' gestation.

preterm premature rupture of membranes (pprom) complicates 3% of pregnancies and accounts for one-third of preterm births. it is a leading cause of neonatal mortality and morbidity and increases the risk of maternal infectious morbidity. in cases of early pprom (22 to 33 completed weeks' gestation), expectant management is recommended in the absence of labor, chorioamnionitis or fetal distress. antenatal steroids and antibiotics administration are recommended by international guidelines. however, there is no recommendation regarding tocolysis administration in the setting of pprom. in theory, reducing uterine contractility should delay delivery and reduce risks of prematurity and neonatal adverse consequences. likewise, a prolongation of gestation may allow administering a corticosteroids complete course that is associated with a two-fold reduction of morbidity and mortality. however, tocolysis may prolong fetal exposure to inflammation and be associated with higher risk of materno-fetal infection, potentially associated with neonatal death or long-term sequelae, including cerebral palsy. the purpose of this study is to assess whether short-term (48 hr) tocolysis reduces perinatal morti-morbidity in cases of pprom at 22 to 33 completed weeks' gestation.

Eligibility criteria:
inclusion criteria: * preterm premature rupture of membranes (pprom) between 220/7 - 336/7 weeks of gestation, as diagnosed by obstetric team * singleton gestation * fetus alive at the time of randomization (reassuring fetal heart monitoring) * 18 years of age or older * french speaking * affiliated to social security regime or an equivalent system * informed consent and signed exclusion criteria: * pprom ≥ 24 hours before diagnosis * ongoing tocolytic treatment at the time of pprom * tocolytic treatment with nifedipine between pprom diagnosis and randomization * fetal condition contraindicating expectant management including chorioamnionitis, placental abruption, intrauterine fetal demise, non-reassuring fetal heart rate at the time of randomization * cervical dilation \> 5 cm * iatrogenic rupture caused by amniocentesis or trophoblast biopsy * major fetal anomaly * maternal allergy or contra-indication to nifedipine or placebo drug components\*: * myocardial infarction * unstable angina pectoris * hepatic insufficiency * cardiovascular shock * beta blockers placebo drug components: lactose monohydrate, colloidal silica, microcrystalline cellulose * coadministration of diltiazem or rifampicin * hypotension (systolic pressure \< 90 mmhg) * participation to another interventional research (category 1) in which intervention could interfere with tocoprom's results (efficacy and safety)

Keywords: preterm premature rupture of membranes tocolysis nifedipine latency neonatal outcome preterm birth randomized controlled trial
the pai trial for breast and colon cancer survivors

Conditions: Breast Cancer; Colon Cancer

Summary: the purpose of the study is to determine if a physical activity index (pai) tool that collects measures on physical activity, strength training and sedentary behavior can be used in a clinical setting to monitor patient behavior and provide specific recommendations on how to achieve and maintain behavior goals. the tool will be used after treatment is completed in breast and colon cancer survivors and will test if physician counseling combined with patient self-monitoring improves physical activity and reduces sedentary behavior over time.


Eligibility criteria:
inclusion criteria: * women ages 60 years or older diagnosed with breast cancer and women or men ages 60 years or older diagnosed with colon cancer within the last 5 years * ≥ 3 months post-completion of last prescribed treatment (i.e., chemotherapy, radiation therapy or surgery) * stages i-iii (no stage 0 or metastatic cases will be included) * able to understand spoken and written instructions in english * participate in 60 minutes or more of mvpa (moderate to vigorous-intensity physical activity)/week for previous 6 months * have internet access or access to data sharing plan * willing to come to four penn state health visits over the course of a year, completing requested questionnaires * willing to use garmin vivofit device, participate in exercise coaching sessions and complete exercise logs between visits exclusion criteria: * prior respiratory, joint or cardiovascular problems precluding pa * metastatic disease * planned elective surgery during intervention/follow-up * exhibit gross cognitive impairment we will not include any of the following vulnerable populations: adults unable to consent, individuals who are not yet adults, pregnant women, neonates, or prisoners.

Keywords: adult cancer survivors geriatrics gerontology
mevalonate kinase gene mutations and their clinical correlations in behçet's disease

Conditions: Behçet's Disease

Summary: background: genetics is suggested to play a critical role in the development of behçet's disease (bd). shared phenotypic features requires an approach to the differential diagnosis from periodic febrile syndromes particularly from mevalonate kinase deficiency related diseases. we planned to study for evaluating the frequency of mutations and their clinical significance in mevalonate kinase gene in turkish patients with behçet's disease.


Eligibility criteria:
inclusion criteria: * behçet patients exclusion criteria: * diagnosis of periodic fever syndromes
influencer e-cigarette and cannabis marketing: a survey-based experiment among adolescents

Conditions: Electronic Nicotine Delivery Systems

Summary: adolescent non-users of e-cigarettes and cannabis (n = 1,462) participated in the in-class survey-based experiment. they were randomly shown 3 pairs of images featuring influencers promoting e-cigarettes alongside cannabis, (experimental group), or no-substance use or display (placebo treatment), or e-cigarette promotion alone (control). after viewing each pair of images, participants rated perceptions of influencer credibility (i.e., honesty, trustworthiness, knowledge) on the scale of 0 (e.g., dishonest) to 100 (honest). susceptibility to use e-cigarettes was assessed after participants viewed all the images. these outcomes were then compared among participants who perceived influencers as credible and those who perceived influencers as non-credible.

adolescents (13-17 years of age) living in california were recruited by tobacco center of regulatory science at the university of southern california (usc tcors) to participate in the advance survey cohort focused on tobacco-related attitudes and behaviors. participants completed the experiment, which was part of the survey at cohort's wave 7, on chromebooks in classroom. all participants provided informed consent and parental assent prior to participating in the experiment. the study was approved by the university of southern california institutional review board (hs-19-00682-am016). respondents were randomly shown 3 pairs of images featuring influencers promoting e-cigarettes (image 1) paired with cannabis (image 2), (experimental group), or no-substance use or display (two images featuring neutral profiles of influencers), (placebo treatment), or e-cigarette promotion (image 1) paired with a neutral profile (with no e-cigarette) of the influencer featured in image 1 (control).

Eligibility criteria:
inclusion criteria: * english fluency, * current california resident. exclusion criteria: not meeting these criteria: * english fluency, * current california resident.
tyrosine kinase inhibitors (tkis) in trastuzumab emtansine (t-dm1) resistant her2-positive metastatic breast cancer: a real-world study

Conditions: Breast Cancer

Summary: this is a real world study to evaluate the efficacy and safety of tyrosine kinase inhibitors after t-dm1 progression.

her2-positive breast cancers account for 15%-20% of all breast cancers. the development of her2 targeted therapies have greatly improved the survival of her2-positive breast cancer patients. trastuzumab emtansine (t-dm1) has shown great effectiveness in treating her2-positive metastatic breast cancer, but therapies subsequent to t-dm1 progression are still controversial. here, we investigated efficacy and safety of tyrosine kinase inhibitors (tkis) based therapy in t-dm1 resistant her2-positive metastatic breast cancer.

Eligibility criteria:
inclusion criteria: * female and 18-70 years old * metastatic or locally recurrent her2-positive breast cancer * patients received tkis-based therapy after t-dm1 failure in treatment for metastasis * complete and accurate medical data exclusion criteria: - incomplete medical data
dose-response of anteroposterior mobilizations in weight bearing talus dorsiflexion

Conditions: Aging Problems

Summary: ankle mobility limitations are common in older adults. a possible treatment to restore joint mobility is manual therapy based on mobilization techniques, in this case, applied on the ankle joint. previous research had proposed different treatment volumes (one to twelve sessions), but shown a different and non-consistent degree of effectiveness according to such factor. therefore, this work aims to determine the dose-response relationship of manual therapy (talus mobilizations) on ankle range of motion in the older adult.


Eligibility criteria:
inclusion criteria: * community-dwelling older adults. * limited ankle mobility (\< 35 degrees). * over 60 years. exclusion criteria: * not willing to participate or signing a consent form * lower limb injury in the three months prior to the study (ex. sprain) * diagnosed condition that may influence mobility assessments (i.e. stroke)

Keywords: weight bearing dorsiflexion manual therapy ankle dose-response
the association between fever and cdkl5 disorder: a nationwide survey

Conditions: CDKL5 Deficiency Disorder

Summary: the primary objective of this research is to study the effects of fever on seizure activity in patients with cdkl5 deficiency disorder

the survey aimed to gather information on seizure during and after fever and hot temperature bath therapy from families of children diagnosed with cdkl5 deficiency disorder through the wechat group. it is expected to to develop new intervention strategies to reduce seizure frequency, improve patient quality of life, and ultimately address the therapeutic challenges faced by the global cdkl5 patient community.

Eligibility criteria:
inclusion criteria: * a diagnosis of cdkl5 deficiency, including molecular confirmation of a pathogenic or likely pathogenic cdkl5 variant and refractory seizures. * parents or guardians are willing to complete and provide information about the child's medical history and fever history after receiving the survey questionnaire online. exclusion criteria: * any history of previous brain disease (trauma, etc.) that likely to precipitate seizures. * presence of any clinical condition that in the opinion of the principal investigator makes the patient not suitable to participate in the trial.

Keywords: cdkl5 drug resistant epilepsy survey research
aripiprazole in adolescents with schizophrenia

Conditions: Schizophrenia

Summary: the purpose of this trial is to test the safety and efficacy of aripiprazole in adolescent patients with schizophrenia for a period of at least 6 weeks.


Eligibility criteria:
inclusion criteria: * primary diagnosis of schizophrenia 1 exclusion criteria: * patients diagnosed with schizoaffective disorder, major depressive disorder, delirium, or bipolar disorder

Keywords: schizophrenia aripiprazole
esgliteo post marketing surveillance (pms) in korean patients with type 2 diabetes mellitus

Conditions: Diabetes Mellitus, Type 2

Summary: the objectives of this study are to monitor the safety and effectiveness of esgliteo in korean patients with type 2 diabetes mellitus in a routine clinical practice setting.


Eligibility criteria:
inclusion criteria: * patients who have started at first time on esgliteo in accordance with the approved label in korea * age ≥19 years at enrolment * patients who have signed on the data release consent form exclusion criteria: * patients with previous exposure to esgliteo * patients with hypersensitivity to the empagliflozin and/or linagliptin or any of the excipients * patients with type 1 diabetes or diabetic ketoacidosis * patients with estimated glomerular filtration rate (egfr) \< 45 ml/min/1.73m2, end stage renal disease, or patient on dialysis * patients for whom empagliflozin/linagliptin is contraindicated according to the local label of esgliteo