Kornimate/medical-research-clean huggingface dataset:
healing of bone/soft tissue to different abutment biomaterials and the impact on marginal bone loss

Conditions: Bone Loss; Inflammation

Summary: in patients that require a dental implant, does zirconia compared to titanium, or cad-cam acrylic abutments, provide less inflammation, marginal bone loss or infection during the osseointegration period ?

place dental implants and zirconia, titanium, acrylic or cad-cam acrylic abutments, torque to 20 n/cm2 evaluate changes in inflammatory levels from t0 (baseline) to t7-12 weeks (measure intermediate points at t0 (baseline),,t1-8 weeks and t2-12 weeks) also evaluate outcomes marginal bone loss, gingival height levels and osseointegration

Eligibility criteria:
inclusion criteria: * single unit implant rehabilitation * maxilla and mandible * must accept treatment plan * must sign informed consent * dental extraction performed at least 3 month prior * must have at least 6 mm of residual bone * absence of oral lesions * keratinized tissue must be present exclusion criteria: * if smoking and/or other drug addiction is present * if local anesthetic allergy is present * patient subjected to chemical or radiotherapy * if hepatic disease is present * if immunodepression is present * if pregnancy is present * if diabetes is present * if heart disease is present

Keywords: dental implants zirconia abutments titanium abutments acrylic abutments gingival healing inflammation bone loss
isolation of vitamin d binding protein isoforms from human volunteers

Conditions: Vitamin D Deficiency

Summary: the purpose of this study is to isolate genotype-specific dbp/gc from homozygous human volunteers and use these purified proteins to cross-validate existing or novel assays for this serum protein and to evaluate the binding characteristics of these variants of dbp/gc for different vitamin d metabolites.


Eligibility criteria:
inclusion criteria: * generally healthy adults (≥ 18 years), non pregnant, with known dbp/gc genotype exclusion criteria: * inability to provide written informed consent * no children or pregnant women * persons with known abnormal serum proteins

Keywords: vitamin d binding protein (dbp)
combined cognitive and functional strength training in children with cp

Conditions: Diplegic Cerebral Palsy

Summary: cerebral palsy is primarily a disorder of movement and posture however; it often involves disorder of different aspects of cognitive function.

this study evaluated the effect of fst and cognitive intervention and their combined effect on motor and cognitive functions in children with spastic diplegia. a convenient sample of spastic diplegic cp children, with their age ranging from 8 to 12 years were assigned randomly into four treatment groups

Eligibility criteria:
inclusion criteria: * chronological age ranged from 8 to 12 years, * spasticity grade in affected lower limbs ranged between 1 + and 2 according to mas * can follow instructions given to them, * their intelligence level ranged from 65 to 80 according to stanford binet intelligence scale, - -- their motor function ranged between level ii \& iii according to gross motor functional classification system expanded and revised (gmfcs e\&r). exclusion criteria: * children who had visual or auditory problems * children who took any medicine affecting alertness * fixed deformities in the joints of upper \& lower limbs * any orthopedic surgery in lower limbs within 6 months before study * epileptic children.
an efficient treatment for posttraumatic injury for firefighters

Conditions: Posttraumatic Stress Disorder; Insomnia; Nightmare

Summary: the goal of this two-arm pilot randomized controlled trial is to test a behavioral intervention that integrates three evidence-based cognitive behavioral interventions (written exposure therapy; wet, cognitive behavioral therapy for insomnia; cbt-i, and cognitive behavioral therapy for nightmares; cbt-n) among firefighters. the main questions it aims to answer are: * is the behavioral intervention feasible, acceptable, and effective in reducing symptoms of posttraumatic stress, insomnia, and nightmares? * what is the efficacy of efficient treatment vs. delayed treatment (2-4 week waitlist) in reducing symptoms of posttraumatic stress, insomnia, and nightmares? we will beta test the intervention in 1-2 groups of 3-5 firefighters. then we will randomize 50 participants to immediate or delayed (2-4 week waitlist) treatment. consented participants will: * complete self-report and interview measures assessing posttraumatic stress disorder, insomnia (ptsd), and nightmares * attend an individual treatment orientation session * attend a 4-day (\~3 hours per day over 4 consecutive days) group treatment that integrates wet, cbt-i, and cbt-n * attend an individual booster session held approximately one week later * complete self-report measures before, during, and after treatment, and at a 3-month follow up assessment and a clinical interview before and after treatment to assess program efficacy.


Eligibility criteria:
inclusion criteria: * 18-65 years old * firefighter * able to speak and read english * clinically significant posttraumatic stress symptoms: caps-5 total score ≥ 25; ≥ 1 intrusion symptom; ≥ 1 avoidance symptom * clinically significant symptoms of insomnia: scisd insomnia criteria are met; isi ≥ 15 * clinically significant symptoms of nightmare disorder: scisd nightmare disorder criteria are met, nightmares ≥ 1 monthly. exclusion criteria: * current suicide or homicide risk meriting crisis intervention * inability to speak and read english * inability to comprehend the baseline screening questionnaires * unwilling to remain abstinent from alcohol during treatment * serious mental health diagnosis such as bipolar disorder or psychosis.
idiopathic recurrent acute pancreatitis (irap)

Conditions: Pancreatitis

Summary: the purpose of this study is to collect standardized data on the diagnosis and management of idiopathic (unknown cause) recurrent acute pancreatitis. the intent is to collect data for at least five years to obtain information regarding long-term outcomes and obtain comparative effectiveness data.


Eligibility criteria:
inclusion criteria: 1. 18 years or older 2. able to provide consent 3. more than one documented episode of pancreatitis (\>3 fold elevation of amylase and or lipase with abdominal pain or with body imaging consistent with pancreatitis: need two of the three) 4. subjects with abdominal pain and enzyme elevation which is \<3 fold above normal or absence of imaging findings: these subjects who are undergoing endoscopic interventions but do not fit the "classic criteria" for pancreatitis will be included but the analysis of data of these subjects would be done separately. note: subjects with a diagnosis of pancreas divisum and or sphincter of oddi dysfunction diagnosed prior to or after entry into the study will be included in the study but their data will be analyzed separately because of the controversy regarding the association of these entities with pancreatitis. exclusion criteria: 1. unable to give informed consent. 2. definite evidence of biliary or alcoholic pancreatitis. 3. clear evidence of hypertriglyceridemia-induced pancreatitis (triglycerides \>1,000 mg/dl). 4. post-ercp pancreatitis, drug-induced pancreatitis, or any identifiable cause for pancreatitis. 5. history of pancreatic surgery.
alternate day buprenorphine administration, phase xii - 17

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to determine if six times daily buprenorphine dose is effective in achieving 120 hour buprenorphine dosing.


Eligibility criteria:
please contact site for information.
a randomized controlled study of mefp for preschool children with adhd

Conditions: ADHD; Child, Only

Summary: the goal of this study is to provide a new, early treatment approach for preschoolers with adhd, which could facilitate the ef developing well to achieve better outcome.

adhd in preschoolers has become established as a valid psychiatric disorder with characterized core deficits of executive function (ef). the ef impairments occurred in preschool period could persist to childhood, adolescent and adulthood, causing extensive and deep damage of individual's academic and career achievement, social function, and peer relationship. psychostimulants remain a controversial opinion for preschoolers and appear less efficacious and more common side effects. it is very important to explore the effective nonpharmacological intervention targeting the ef deficits and appropriately tailored to young children. therefore, the investigators conduct this randomized and controlled study to find out the therapeutic efficacy of metacognitive executive function training for preschool children with adhd (mefp), and follow the subjects to observe whether the therapeutic efficacy would persist. in the mean time, the investigators also observe the factors which can influence the therapeutic efficacy. the goal of this study is to provide a new, early treatment approach for preschoolers with adhd, which could facilitate the ef developing well to achieve better outcome.

Eligibility criteria:
inclusion criteria: 1. meet both the criteria of adhd based on the interview by the dipa and clinical diagnosis with dsm-5; 2. full-scale iq estimated by the wechsler primary and preschool scale of intelligence (wppsi) above 80; 3. their parents volunteered to participate in this study. exclusion criteria: 1. child with severe mental disorder or physical disease that might interfere the assessment and intervention, such as autistic spectrum disorder(asd), schizophrenia, epilepsy, traumatic brain injury, etc.; 2. receive medication intervention for their adhd symptoms before study; 3. parents with severe mental illness, such as schizophrenia, mood disorder (period of onset), etc..

Keywords: adhd executive function preschool intervention
a prospective randomized controlled trial of lower abdominal three-port laparoscopic cholecystectomy

Conditions: Gallbladder Stone; Gallbladder Polyp

Summary: we have designed a new method which could be used in laparoscopic cholecy- stectomy.account to this new method, the three incisions are all located on the lower abdominal, theoretically it could get more beautiful outlook and less stress response than traditional laparoscopic cholecystectomy(two of the three incisions located on upper abdomen) or single port laparoscopic cholecystectomy(one large incision located on umbilicus). we plan to conduct a randomized controlled trial to compare those there methods of laparoscopic cholecystectomy, in order to find out if there will be some advantages of this new method,such as in lowering the stress response,reducing impact on respiration, relieving post-operation pain and improving appearance.


Eligibility criteria:
inclusion criteria: * age from 18 to 70 years old * benign diseases of gallbladder * selective cholecystectomy * capable to read and write exclusion criteria: * accept upper abdominal operation before * acute cholecystitis * with serious heart or pulmonary diseases * with diseases of immune system * pregnant women * can not understand the research purposes * relatives of researchers
detection of influenza a, influenza b, and rsv using the liat™ assays on the liat™ analyzer

Conditions: Influenza A; Influenza B; Respiratory Syncytial Virus (RSV)

Summary: the objective of this study is to evaluate the clinical sensitivity and specificity of the liat™ influenza a/b \& rsv assay and the liat™ influenza a/b assay when used on the liat analyzer to detect the presence or absence of influenza a, influenza b, and rsv in a nasopharyngeal swab specimen as compared to an fda approved naat and culture.


Eligibility criteria:
inclusion criteria: * patients exhibiting 2 or more symptom groups characteristic of influenza and/or rsv at the time of visit or within the past 48 hours: 1. fever of at least 37.8 c (100f) 2. runny or stuffy nose 3. coughing, wheezing or difficulty breathing 4. sore throat, headache, extreme tiredness, or muscle aches 5. infants: decreased activity, irritability, poor feeding * subject who are able to understand and consent to participation; for minors under the age of 18, this includes a parent or legal guardian exclusion criteria: * patients who are under-going anti-viral medication now or within the last 7 days. * patients who received nasal spray flu vaccine within the last 6 weeks
a prospective study to evaluate clinical performance of thermalytix in detecting breast cancers

Conditions: Breast Cancer; Early Detection of Cancer

Summary: the purpose of this study is to determine the clinical performance of ai-based thermalytix with the current standard-of-care diagnostic modalities in women.

while mammography is the most accepted breast cancer screening test, it is less sensitive in women with dense breast tissue, who have a four fold high risk for developing breast cancer. thermalytix is a novel automated breast cancer screening solution that uses artificial intelligence (ai) over thermal images to detect and localise breast cancer lesions in women. in this study the performance of thermalytix over mammography is evaluated in women with dense and non-dense breast tissue who presented for a health check-up at a hospital. all women underwent thermalytix and mammography, and participants who were reported as positive on either test were recommended for further investigations. sensitivity, specificity, positive predictive value, and negative predictive value were calculated across age-groups, menopausal status, and breast densities against the current standard-of-care diagnostic modalities.

Eligibility criteria:
inclusion criteria: 1. female subjects equal to and above 18 years 2. subjects who are willing to give written informed consent for study participation 3. subjects who are ready to comply with the study related visits and procedures exclusion criteria: 1. subjects who are pregnant 2. subjects who are lactating 3. subjects who have undergone either lumpectomy or mastectomy 4. subjects who have undergone chemotherapy in the last 2 weeks at the time of study enrollment 5. any active illness, psychological and/or pathological condition that would interfere with study participation in the opinion of the investigator

Keywords: breast cancer thermography thermalytix artificial intelligence machine learning dense breasts breast density mammography breast cancer screening
mcat versus vista with volume stable collagen matrix in rt3 gingival recession

Conditions: Gingival Recession

Summary: this study aims to compare mcat technique (supraperiosteal approach with coronal advancement of flap) with vista technique(subperiosteal approach with coronal advancement of flap), further, it may be hypothesized that supraperiosteal placement of graft material (in mcat technique) may be better due to better blood supply, and mcat technique utilizes a microsurgical concept, including microsurgical blades and suture material, which improves wound healing and establishes a better esthetic result and results in better outcome in terms of root coverage percentage compared to vista. therefore, this study aims to compare minimally invasive technique mcat and vista using vcmx as a graft in rt3 gingival recession in anterior teeth.

gingival recession is the migration of the gingiva to a point apical to the cement-enamel junction and is considered one of the most common periodontal problems.besides aesthetic complaints, gr may also cause root hypersensitivity, risk for development of caries or non-carious cervical lesions, and difficulties to achieve optimal plaque control. in modified coronally advanced tunnel (mcat) technique partial-thickness flap is created on the entire buccal aspect, no parts of the alveolar bone are exposed, and resorption of bony structures, which occurs when using a full-thickness flap can be avoided, also,it minimizes trauma and ensure a better blood supply for the graft. zadeh h. in 2011 introduced a conservative modification in tunnel technique; vestibular incision subperiosteal tunnel access (vista) which preserve the papillary integrity and enhances patients compliance. vista technique allows gingival tissue regeneration through subperiosteal undermining of soft tissues using a vestibular incision instead of elevating the whole flap.vista offers broader access and maximum esthetic outcome because of placement of incision in the frenum region.

Eligibility criteria:
inclusion criteria- * patients with rt 3 isolated recession defects present labially in anterior teeth region,with vestibular depth\>=6mm * systemically healthy individuals. * age \>18 years old. * a full mouth plaque score (fmps) and full mouth bop (fmbop) \< 20% * patient showing adequate compliance and willing to participate in the study. exclusion criteria- * patients having systemic disease such as hypertension, diabetes, hyperthyroidism or on medication that influence the outcome of periodontal therapy. * previous surgical attempt to correct gingival recession. * crowding of affected teeth and tooth without adjacent contact teeth. * patients with active periodontal disease. * smokers and tobacco users. * pregnant and lactating women. * involved tooth with trauma from occlusion * involved tooth with prosthesis. * endodontically treated tooth. * tooth with cervical abrasion/undetectable cej/ caries.

Keywords: gingival recession esthetics phenotype
the effects of the endocrine system on endometrial cancer

Conditions: Endometrial Cancer

Summary: endometrial cancer usually begins in the endometrium, which is the tissue lining of the uterus. endometrial cancer is the most commonly diagnosed gynaecological malignancy in australia. it affects 1 in 80 australian women and there are about 1400 new cases and 260 deaths from the disease every year. most affected women are aged between 50 and 70 years. the purpose of this study is to investigate the possible role of the endocrine system in the regulation of human endometrial cancer. by looking at the laboratory results of people with endometrial cancer and also those without endometrial cancer we hope to gain a better understanding of how endometrial cancer develops and progresses. this may lead to the development of new, effective therapies for endometrial cancer.


Eligibility criteria:
inclusion criteria: * women aged 18 years or older * having a hysterectomy for the treatment of endometrial cancer, fibroids, chronic pelvic pain or abnormal uterine bleeding * have provided informed consent

Keywords: hysterectomy endometrial cancer benign endocrine system tissue collection
a gratitude intervention in improving well-being and coping in people living with inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases

Summary: the primary aim of the proposed research is to investigate the extent to which a one-week online gratitude intervention can improve levels of wellbeing in individuals living with inflammatory bowel disease (ibd). a secondary aim was to investigate the extent to which dispositional gratitude influences levels of coping and wellbeing and to what extent this mediates the effect of the intervention. participants with ibd will be randomized to either treatment or control group. participants will complete measures pre- and post- intervention, and follow-up (eight weeks) measuring: gratitude (state and trait), illness severity, mood, stress and coping.


Eligibility criteria:
inclusion criteria: * diagnosis of inflammatory bowel disease from a clinician. exclusion criteria: * no access to internet via smartphone, tablet or computer. * cannot read english
evaluation of advanced prf combined with nano-crystalline hydroxyapatite for management of grade ii furcation defects

Conditions: Periodontitis

Summary: this study is to evaluate the use of advanced platelet rich fibrin (a-prf) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (opd) versus open flap debridement alone in the management of mandibular molar grade ii defects. in the management of mandibular molar grade ii furcation defects, no difference exists in gain of horizontal clinical attachment level between the use of advanced platelet rich fibrin (a-prf) + with nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (opd) and open flap debridement (opd) alone .


Eligibility criteria:
inclusion criteria: patient-related criteria: * systemically healthy patients. * compliance with oral hygiene instructions and the maintenance program provided. * accepts the 6 months follow-up period. * provide informed consent. teeth related criteria: * mature permanent tooth. * asymptomatic mandibular molar with buccal glickman class ii furcation involvement. * probing depth (pd) ≥ 5 mm and vertical pd ≥ 3 mm after phase i therapy (scaling and root planing). * presence of radiolucency in the furcation area on an intra-oral periapical radiograph exclusion criteria: patient-related criteria: * patients taking drugs known to interfere with periodontal wound healing in the last six months. * pregnant or nursing women. * smokers. * uncooperative patients. teeth related criteria: * teeth with interproximal supra-bony or intrabony defects. * teeth with gingival recession. * teeth with grade ii or iii mobility.
fully covered or partially covered stents in malignant esophageal strictures

Conditions: Esophageal Cancer; Esophageal Stenosis

Summary: the purpose of this study is to determine whether fully covered or partially covered metal stents are more favorable in incurable malignant stenosis of the esophagus or cardia. primary outcome will be the occurence of recurrent dysphagia which is defined as dysphagia due to a stent or tumour related cause in a 6-month follow-up


Eligibility criteria:
inclusion criteria: * malignant stricture of the esophagus or cardia * no curative treatment options available * dysphagia grade of at least 2 (i.e. swallow semi-solid foods or less) * informed consent * age ≥ 18 years exclusion criteria: * previous treatment with self-expandable metal stent for same condition * evidence of tumor within 2 cm of the upper esophageal sphincter. * presence of an esophago-tracheal or -bronchial fistula or both. * not able to undergo upper endoscopy

Keywords: esophageal cancer esophageal stenosis stent endoscopy