Kornimate/medical-research-clean huggingface dataset:
better living with non-memory-led dementia

Conditions: Primary Progressive Aphasia; Frontotemporal Dementia; Alzheimer Disease

Summary: this is a feasibility study on the effects of an online-based training and education programme for carers of people with posterior cortical atrophy (pca), primary progressive aphasia (ppa) and behavioural-variant frontotemporal dementia (bvftd).

the purpose of this study is: to evaluate the feasibility of an online training course for carers of people with pca, ppa, and bvftd. feasibility measures will focus on the recruitment process and measurement tools. to determine the acceptability of an online training course for carers of people with pca, ppa and bvftd. the study will involve 6 online modules over the course of 7 weeks. all sessions will take place over the internet, using an online platform. a research team member (facilitator) will be available to assist participants over the course completion.

Eligibility criteria:
inclusion criteria: 1. . adults (18+) who self-identify as an unpaid carer (partners, children, friends, etc.) of someone with ppa, pca or bvftd who is not living in a full-time care facility. 2. . the care recipient has to have a confirmed diagnosis of dementia (through self-report of the carer, to reflect the 'real world' application of the intervention). exclusion criteria: 1. . those unable to comprehend written english 2. . those with no access to the internet

Keywords: "posterior cortical atrophy"
can austrian lung specialists' assessments of lung cancer screening be influenced by a fact box?"

Conditions: Lung Cancer

Summary: lung cancer is the most frequently dianosed cancer worldwide. to date, no screening method has been able to establish itself as routinely recommended by the guidelines. in this prospective study with 1:1 randomized questioning using an internet tool, physicians will be asked in 2 phases (before and after intervention with a fact box) about their assessment of the benefits and risks of lung cancer screening by thoracic computed tomography and about a potential intention to change referral behavior. randomly assigned, half of the participants will receive the same information in addition to the fact box graphically presented as a cates plot.

the topic of lung cancer screening is highly topical and relevant in that this cancer is the most frequently diagnosed worldwide and has the highest mortality among malignancies. to date, no screening method has been able to establish itself as routinely recommended by the guidelines. in the recently published dutch-belgian nelson study on low dose thoracic ct as a screening method in high-risk patients (smokers and ex-smokers), an - albeit small - reduction in mortality was shown in the screening group vs. the control group). a prerequisite for a detailed information of the patient about the implementation as well as the advantages and disadvantages of screening is that the physician has risk competence and knows and is able to interpret the screening data. the use of a fact box can be used to improve knowledge of statistical data. in this prospective study with 1:1 randomized questioning using an internet tool, physicians will be asked in 2 phases (before and after intervention with a fact box) about their assessment of the benefits and risks of lung cancer screening by thoracic computed tomography and about a potential intention to change referral behavior. randomly assigned, half of the participants will receive the same information in addition to the fact box graphically presented as a cates plot.

Eligibility criteria:
inclusion criteria: * members of the austrian society of pneumology (ögp) with a completed pulmonary subject and members of the austrian radiological society (örg), society for medical radiology and nuclear medicine with a completed subject. exclusion criteria: * non members of the austrian society of pneumology (ögp)

Keywords: screening
effect of functional treatment on mandibular asymmetric growth

Conditions: Temporomandibular Joint Disorder

Summary: temporomandibular joint (tmj) arthritis is known to alter the mandibular development in children diagnosed with juvenile idiopathic arthritis. in a number of cases a genuine breakdown of cartilage and bone is seen in the affected joint which leads to asymmetric mandibular growth in the affected side. in cases of unilateral tmj involvements severe mandibular asymmetric mandibular growth deviations are seen. we hypothesize that these growth deviations can be minimized and controlled by the use functional orthodontic appliance therapy.

this is a retrospective study design with the aim to evaluate the clinical procedures we have used the last 15 years to treat jia patients with unilateral tmj arthritis. more specifically, the purpose is to evaluate the mandibular growth in all jia patients with unilateral tmj arthritis and an asymmetric mandibular growth pattern treated with non-surgical distraction splint therapy between 1994 and 2010 at the dep. of orthodontics, aarhus university, denmark. the evaluation is based on radiological examinations at the beginning of their non-surgical distraction treatment as well as after the patients have finished their distraction-splint therapy.

Eligibility criteria:
inclusion criteria: * juvenile idiopathic arthritis patients diagnosed with unilateral temporomandibular joint arthritis and an asymmetric mandibular growth pattern exclusion criteria: * juvenile idiopathic arthritis patients diagnosed with bilateral temporomandibular joint arthritis * juvenile idiopathic arthritis patients with no mandibular growth potential left.

Keywords: mandibular growth temporomandibular arthritis
comparative effects of levator ani release and post isometric relaxation among patients with coccydynia

Conditions: Coccydynia

Summary: to compare the effects of levator ani release and post isometric relaxation on pain, disability and quality of life among patients with coccydynia

coccygodynia, also known as coccalgia, coccygeal neuralgia, or tailbone pain, is the word used to describe the pain symptoms that develop in the coccyx region. the discomfort is typically brought on while the person is sitting down, but it can also start when the person stands up. the majority of instances get well within a few weeks to months, but for certain people, the pain might last longer and have an adverse effect on quality of life. due to the complexity of coccygeal pain in these people, management can be challenging. the aim of the study is to compare effects of levator ani release exercises and post isometric in patients with coccydynia. a randomized control trial will be conducted at jinnah hospital lahore through convenience sampling technique on 46 patients which will be allocated through simple random sampling through sealed opaque enveloped into group a and group b. group a will be treated with levator ani release exercises and group b will be treated with post isometric relaxation techniques. outcome measure will be conducted through pain and disability questionnaire at baseline and after 4 weeks. data will be analyzed using spss software version 21. after assessing normality of data by shapiro - wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.

Eligibility criteria:
inclusion criteria:• * both gender * age between 20-40 years * drivers * office workers * computer users * both gender * age between 20-40 years * drivers * office workers * computer users exclusion criteria: * neurological disorders, * bone deficits, * vascular abnormalities, * rheumatoid arthritis * ankylosing spondylitis * fracture * tumor

Keywords: coccydynia levator ani pain post isometric relaxation
evaluation of the treatment of thoracic & cardiovascular disease with biological therapy: clinicalcellregistry.com

Conditions: Cardiovascular System Diseases (& [Cardiac])

Summary: this is the clinical registry of cell based therapies that is available to researchers around the world. the registry is web based. all researches must provide irb approval to the coordinating site- university of utah in order to obtain access to the registry. the are predetermined case report forms for cardiovascular diseases that are currently in clinical trials- including demographics, safety, and possible efficacy end-points. all investigators have access to their own data. the servers are u.s. hippa compliant and protected with secure back-up.

the clinical cell registry includes data on thoracic and cardiovascular diseases including: acute myocardial infarction, chronic angina, heart failure, wound healing including sternal, peripheral arterial disease, critical limb ischemia, type 2 diabetes, copd, asthma. neurological disorders registry is available to specifics sites if requested. our own biological data at the university of utah including co-localized data with society of thoracic surgeons also is a part of this program. cell based therapies that are autologous and allogeneic are included in the registry

Eligibility criteria:
inclusion criteria: * age \>=18 years old * approved consent to be enrolled in trial/registry exclusion criteria: * prior malignancy in the 5 years before treatment in this study (other than curatively treated carcinoma in-situ of the cervix or non-melanoma skin cancer) * inability or unwillingness to comply with the treatment protocol, follow-up, research tests, or give consent

Keywords: stem cell heart lung vascular cell therapy registry
defining the molecular and radiologic phenotype of progressive ra interstitial lung disease

Conditions: Rheumatoid Arthritis; Interstitial Lung Disease

Summary: a study to identify patients with rheumatoid arthritis - associated interstitial lung disease (ra-ild) that are at the highest risk for progression. the goal of the investigators is to recruit a group of patients with ra-ild and collect information to help us understand more about disease progression. the investigators will do this using a combination of clinical, radiologic, and biologic features.

the central hypothesis is that novel quantitative imaging and specific blood markers will be associated with progressive ra-ild. the hypothesis will be tested through collection and analysis of peripheral blood, in addition to the analysis of hrct (high-resolution computed tomography) scans performed as standard of care (clinical) on research subjects. procedures performed: baseline year 0: blood sample, buccal (cheek) swab, questionnaires and if performed clinically - pulmonary function tests, 6 minute walk test, and hrct scan of lungs every 4 months (at clinic visit): blood sample, questionnaires year 1 and year 2 follow-ups: blood sample, buccal (cheek) swab, questionnaires and if performed clinically - pulmonary function tests, 6 minute walk test, and hrct scan of lungs

Eligibility criteria:
inclusion criteria: * multidisciplinary diagnosis of ra-ild based on the 2010 american college of rheumatology criteria * 18 years of age or older exclusion criteria: * prior medication treatment specifically for ra-ild * inability to give informed consent * pregnant women
awareness of parents about management of dental avulsion

Conditions: Dental Trauma

Summary: aim of the study: assessment of level of awareness of parents about emergency management of permanent teeth avulsion in children

our study asses level by awareness of parents about emergency management of dental avulsion through questionnaire , the study will be done in diagnosis clinic of faculty of oral and dental medicine cairo university

Eligibility criteria:
inclusion criteria: * parents who have children aged from 6 to 12 years exclusion criteria: * parents who refused to participate in questionnaire * parents who have children above or below this age
comparison of the performance between conventional colonoscopy and 3d colonoscopy in positive fecal immunochemical test group

Conditions: Adenoma Detection Rate; Colonoscopy; Three Dimensional; Fecal Immunochemical Test

Summary: background: adenoma detection rate is one of the most quality indicator: an accumulating body of evidence has shown that detection and resection of pre-cancerous adenoma by colonoscopy could effectively prevent colorectal cancer (crc) and its related mortality1,2. among various colonoscopy quality indicators, such as cecal intubation rate, withdrawal time, and adenoma detection rate (adr), adr is the most important one and most closely associated with the subsequent risk of crc3,4. a recent study further demonstrated the improvement of adr could reduce subsequent risk of crc5. equipment and technique to improve adr: to be noted, among all colorectal neoplasm, non-polypoid lesions, such as flat or depressed lesions, carries higher likelihood to be overlooked during conventional colonoscopy and these overlooked lesions were the main etiology of post-colonoscopy colorectal cancer (pccrc)6. nowadays, several colonoscopy technologies had been developed to enhance the detection of colorectal adenoma such as using digital or dye-spray chromoendoscopy7 or add-on device such as cap/endocuff/third eye/fuse-assisted endoscopy8. among them, some had showed the potential to enhance the detection of non-polypoid lesion, for example, the next-generation nbi9 or iscan10. application of 3d endoscopy on gi disease: 3d endoscopy is a new technology that using image processing technique to offer more information on tissue depth in comparison with conventional 2d endoscopy. the utility of 3d endoscopy on gi tract was mainly from upper gi tract and it was proved to enhance the diagnostic accuracy on superficial gastric tumors11 and shortened the procedure time during performing gastric endoscopic submucosal dissection (esd)12. however, few is known that whether 3d colonoscopy could enhance the adr, especially for non-polypoid lesion detection, during colonoscopy examination. positive fecal immunochemical test(fit) group among subjects who receive colonoscopy examination, higher advanced adenoma or invasive caners were found in fit positive group. however, still about half of positive fit subjects who received colonoscopy exam, have negative colonoscopy result. non polypoid lesions could be overlooked during the colonoscopy. therefore, we tried to use this prospective, multicenter, randomized control study to demonstrate the efficacy of 3d colonoscopy on adenoma detection in comparison with conventional 2d colonoscopy in this kind of high risk group.


Eligibility criteria:
inclusion criteria: * subjects who are 40 years of older * subjects who have positive fecal immunochemical test exclusion criteria: * contraindication for colonoscopy * subjects with familiar or hereditary polyposis * subjects with history of colectomy * inadequate bowel cleansing level * subjects with inflammatory bowel disease

Keywords: colonoscopy adenoma detection rate 3d fecal immunochemical test
a prospective study to identify predictive biological markers in blood and cyst fluid aspirates from patients with pancreatic cyst lesions

Conditions: Pancreatic Cystic Lesions

Summary: the purpose to determine the diagnostic potential of various biological markers in blood and cyst fluid aspirates from patients with pancreatic cystic lesions (pcls). research design this is a 10-year prospective cohort and pancreatic cyst fluid repository study enrolling all patients diagnosed with pancreatic cyst and undergoing the cyst aspiration. procedures to be used blood sample cyst fluid sample data collection: medical record number demographics (age, sex, gender, race) contact information history of alcohol use and iv and other recreational drugs and narcotics use/abuse medication history past hospitalizations, diagnoses, and treatment physical examination findings imaging data of abdominal and chest regions, including and not limited to ultrasonography, magnetic resonance imaging (mri), computed tomography (ct) future admissions, diagnoses, treatment including histopathological findings of resected specimens and blood reports end of study data: clinical progression of disease, cyst size, wall thickening, calcification, communication with pancreatic duct, string sign, cytology, immunohistochemical findings, assay levels of lipase, amylase cea (carcinoembryonic antigen), carbohydrate antigen19-9 (ca 19-9), and other biomarkers. risks and potential benefits the risks associated with this study are slight discomfort or bruising from the blood sampling and the possible loss of confidentiality if the patient data or information is inadvertently disclosed outside of this study. the patient will not receive any additional benefit from the study aside from those received as part of routine standard of care. importance of knowledge that may reasonably be expected to result the knowledge gained from this study may benefit other patients with pancreatic cyst lesions in the future.


Eligibility criteria:
inclusion criteria: * diagnosis of pancreatic cystic lesions (pcls) or acute pancreatitis (ap) or chronic pancreatitis(cp) or pancreatic cancer (pc) (any stage/grade) or congenital developmental anomalies of the pancreas. * any combination of the diagnoses above. * patients must provide written informed consent for the collection of blood specimens for research purposes. * patients with pcls must provide informed consent for collection of excess cyst fluid aspirate remaining after testing for routine standard of care * patients with pancreatic cystic lesions (pcls) or ap or cp or pc (any stage/grade) or congenital developmental anomalies of the pancreas undergoing surgery must provide informed consent for collection of surgical specimen exclusion criteria: * patients with co-existing malignancies of other organs (or prior history of such) * patients unable to provide informed consent * patients unable to complete follow up
topic insulin accelerates wound healing in diabetes

Conditions: Diabetes Mellitus; Wounds

Summary: the purpose of this study is to determine whether topic insulin is effective to accelerates wound healing in diabetes patients

wound healing is impaired in diabetes mellitus, but the mechanisms involved are not well established. the purpose of this study was to investigate the effect of a topic insulin cream on wound healing in diabetic patients. age eligible for study:18 years old-older gender eligible for study:both accepts healthy volunteers:no have a proband with t1dm or t2dm. a proband is an individual with more than one year of diagnosis. have proband with a wound that is difficult to be healed for at least three months. patients with serum creatinine \<1.5mg/dl does not satisfy the above inclusion criteria infection diagnosed wound patients with cellulitis, venous stasis, inadequate perfusion, osteomyelitis and patient's inability to attend clinics for follow up

Eligibility criteria:
inclusion criteria: age eligible for study:18 years old-older gender eligible for study:both accepts healthy volunteers:no have a proband with t1dm or t2dm. a proband is an individual with more than one year of diagnosis. have proband with a wound that is difficult to be healed for at least three months. patients with serum creatinine \<1.5mg/dl exclusion criteria: does not satisfy the above inclusion criteria infection diagnosed wound patients with cellulitis, venous stasis, inadequate perfusion, osteomyelitis and patient's inability to attend clinics for follow up

Keywords: wound healing diabetes mellitus
video consultation during follow up surgical care

Conditions: Colorectal Cancer

Summary: the aim of this study was to compare the willingness to use and attitude towards vc amongst both patients with colorectal cancer and healthcare providers during follow up care. second, to determine the satisfaction with the quality of the healthcare provider and the usability of the used vc technology. 50 patients will be asked to choose between video consultation or face-to-face contact at the outpatient surgical clinic.


Eligibility criteria:
inclusion criteria: * age 18 years or older * fluent in speaking and writing in dutch * follow up appointments in which overall progress, new complaints, results with good news and treatment was discussed were considered feasible. exclusion criteria: * introductory appointments * bad news consultations * physical examination needed * no access to internet * no access to a smartphone, tablet or computer with a camera * not willing to activate their electronic patient portal

Keywords: video consultation virtual visits
faecal microbiota transplantation for liver cirrhosis

Conditions: Liver Cirrhosis

Summary: the purpose is to investigate the effect of faecal microbiota transplantation (fmt) on complications, progression, and mortality of patients with liver cirrhosis. further, the investigators want to examine the impact of fmt on the gut microbiota, gut barrier function, systemic inflammation, and immune function.

patients with liver disease have a disturbed gut microbiota. this is often associated with disease progression and development of complications, so-called episodes of decompensation. in this trial, we will change the microbiota of these patients by transferring a healthy microbiota through faeces from a healthy donor, a procedure known as faecal microbiota transplantation (fmt). we will examine the effect of fmt on the prognosis and disease progression of the patients. further, we will examine the mechanistic effects of fmt. we will at random divide 220 patients admitted with decompensation of liver cirrhosis evenly into two groups. one group will receive fmt and the other group will receive placebo. after the treatment, we will follow the patients for one year and examine disease progression as well as changes in their gut microbiota, gut barrier, and immune function.

Eligibility criteria:
inclusion criteria: * age 18-75 years * liver cirrhosis with child-pugh ≤ 12 * acute decompensation requiring intervention (ascites, gastrointestinal bleeding, infections leading to progressive liver failure, overthepatic encephalopathy, alcoholic hepatitis) exclusion criteria: * more than one organ failure defined by clif-sofa score * untreated malignancy apart from non-melanoma skin cancer * untreated viral hepatitis * hiv * inflammatory bowel disease * celiac disease * clostridioides difficile infection * pregnancy * unable to participate based on medical judgement

Keywords: hepatic encephalopathy ascites gastrointestinal bleeding spontaneous bacterial peritonitis hepatorenal syndrome alcoholic hepatitis