Kornimate/medical-research-clean huggingface dataset:
effects of multimodal physical therapy with and without mcconnell taping in patients with anterior knee pain.

Conditions: Anterior Knee Pain Syndrome

Summary: this study aims to determine the effect multimodal physical therapy with and without mcconnell taping on pain, functional limitation and severity of symptoms in patients with anterior knee pain.

the term "anterior knee pain" is often used interchangeably with "patellelofemoral pain syndrome" (pfps or " runner's knee" which involves stiffness and pain when patellofemoral joint is loaded with different activities that require prolonged knee flexion, stairs climbing or descending , running, kneeling and squatting. multimodal therapy and tapping techniques are useful for reducing pain and improving functional activities of patient daily living. in this randomized clinical trial, thirty participants with anterior knee pain will be randomly assigned to one of the two intervention groups: group a: group a will be treated with multimodal physical therapy program with mcconnell taping. group b: group b will be treated with multimodal physical therapy program without mcconnell taping. randomization will be performed using a convenient random sampling method via lottery method. each participant will receive a total of 12 treatment sessions. over a four-week period. the effects of the interventions will be assessed at the beginning (first session), conclusion (eight session). participants will be followed up after 4 weeks again. outcome measures, including pain intensity, functional limitation and severity of symptoms will be evaluating using the visual analog scale (vas), lower extremity functional scale (lefs) and anterior knee pain scale (akps) respectively. data will be analyzed using spss software version 25. normality of data will be assessed using the shapiro-wilk test. for within-group comparisons, paired t- test will be used. to compare changes between the groups, the independent t-test will be applied, depending on the data distribution. the analysis of these outcome measures will provide. valuable insights into the impact of the interventions on participants' pain, functional limitation and severity of symptoms.

Eligibility criteria:
inclusion criteria: * age 17-35 years, both male and female. * unilateral or bilateral pain lasting for more than 2-3 months. * diagnosed with patellofemoral pain by orthopedic surgeon through clinical and radiological findings. * positive patellofemoral grinding test, negative mccurry test and full knee range of motion. * pain grade 3-6 by visual analogue scale (vas). * pain at least in two of these positions: sitting for long time with knee bends, going up and down the stairs, squatting and running, kneeling. exclusion criteria: * history of ligament sprain, meniscal injury, knee fracture, patellar dislocation and knee osteoarthritis. * true knee joint locking or giving away and tibial or iliotibial track tendinopathy. pregnancy. * developmental dysplasia of hip and undergoing any medical treatment. * spinal surgery and neurological disorders.

Keywords: anterior knee pain mcconnell taping patellofemoral pain syndrome.
examining arts as targeted elements of childhood cancer treatment, create trial

Conditions: Hematopoietic and Lymphatic System Neoplasm; Malignant Solid Neoplasm

Summary: this clinical trial is being done to develop and test how well creative arts interventions (drawing, painting, making sculptures) compared to watching videos can affect symptoms and impact the quality of life in children with cancer. creative arts mind-body interventions (cra) are one type of complementary health interventions which have been associated with improved quality of life and reduced symptom burden among children with cancer. cra is an ideal intervention for children with cancer due to the long hours spent in the hospital setting for treatments, the creativity and developmental focus of children, and their potential ability to communicate more easily through art than words. researchers want to develop and test a cra intervention to help improve symptoms and the quality of life of children with cancer.

primary objective: i. feasibility of an randomized controlled trial (rct) of art among children with cancer. secondary objectives: i. achieve recruitment rate target. ii. achieve accrual target. iii. achieve fidelity to intervention. iv. assess initial effect sizes. outline: phase i: patients participate in focus groups to develop cra intervention on study. phase ii: patients are randomized to 1 of 2 arms. arm i: patients participate in cra interventions comprising drawing, painting, and making sculptures with a trained artist for 30 minutes once a week for 4 sessions over 12 weeks. arm ii: patients passively watch videos for 30 minutes once a week for 4 sessions over 12 weeks.

Eligibility criteria:
inclusion criteria: * aged 8 to 13 years of age * have been diagnosed with cancer of any type in the prior 12 months * be english literate (we will amend this criterium when the study surveys are validated in spanish) * physically and cognitively able to participate in creative arts exclusion criteria: * not english literate * otherwise unable to complete study procedures
the effect of the core stabilization training on respiratory parameters , functional capacity and balance in scoliosis

Conditions: Adolescent Idiopathic Scoliosis

Summary: the vertebral column is a structure that transfers the weight of the head and torso to the lower extremity, provides trunk movements and protects the spinal cord.a three dimensional deformity involving lateral flexion of the vertebrae in the frontal plane at 10 ° and above, including axial rotation and physiologic flexion (hypokyphosis) components in the sagittal plane, is defined as scoliosis. adolescent idiopathic scoliosis (ais) is a type of idiopathic scoliosis that occurs in the period from the onset of puberty (up to 10 years) until the closure of growth plates. scoliosis is caused by postural, balance and neuromotor disorders as a primary cause of impaired sensory integrity, proprioceptive feedback deficits, secondary lung problems, organ disorders and pain. in addition, the quality of life in these individuals is also seen to decrease.children with adolescent idiopathic scoliosis have inadequate respiratory function and a decrease in functional capacity. at the same time, these children show muscle weakness in certain parts of the body. the aim of this study was to investigate the relationship between home based core stabilization training, respiratory parameters, peripheral muscle strength, balance, functional capacity and quality of life in individuals with young scoliosis. the investigators suggest that the addition of core stabilization training to children with mild and moderate adolescent idiopathic scoliosis will produce good results.


Eligibility criteria:
inclusion criteria: * adolescent idiopathic scoliosis diagnosis exclusion criteria: * documented diagnosis any of cardiopulmonary, neurological, orthopedic or mental disorders which may affect the assessments results. * subjects previously undertaken any of spinal surgeries. * subjects involved in exercise training 3 or more days a week.

Keywords: adolescent idiopathic scoliosis scoliosis core stabilization training exercise training pulmonary function test 6 - minute walk test peripheral muscle strength balance with biodex quality of life
clinical trial to evaluate the bioavailability and safety of agsav301

Conditions: Hypertension

Summary: the purpose of this study is to evaluate the bioavailability and safety of agsav301 tablet in healthy male volunteers.


Eligibility criteria:
inclusion criteria: * adult males 20 to 40 years at screening. * body weight ≥ 45kg and within ± 20% of the ideal body weight : ideal body weight = (height \[cm\] - 100) x 0.9 * be able to collect blood for study and visit for follow-up period * subject who agrees to participate in this study and give written informed consent exclusion criteria: * have history of significant hepatic, renal, gastrointestinal, pulmonary, musculoskeletal, endocrine, neuropsychiatric, hematologic, cardiovascular diseases * have a gastrointestinal disease(ex : crohn's disease, gastrointestinal ulcer)or surgery(except for appendectomy, hernia repair) affected the absorption of medications * inappropriate in screening test (interview, vital sigh, bp, 12-lead ecg, laboratory test etc.) * hypersensitivity reactions to drugs or clinically significant hypersensitivity reactions in the history of amlodipine or valsartan * drug abuse, or have a history of drug abuse showed a positive for the screening test on urine : amphetamine, barbiturate, cocaine, opiates, benzodiazepines, cannabinoids, methadone etc. * subject who takes herbal medicine within 30 days, ethical drug within 14 days, otc within 7 days before the beginning of administration of investigational drug * unusual diet affected the absorption, distribution, metabolism, excretion of medications * subject who treated with any investigational drugs within 60 days before the administration of investigational drug * previously donate whole blood within 60 days or component blood within 30 days or transfusion within 30 days * subject who takes inhibitors and inducers of drug metabolizing enzyme (barbiturates etc.) within 30days * subject who have taken habitually caffeine (caffeine \> 5 units/day) * subject who have drunken habitually (alcohol \> 21 units/week, 1 unit = pure alcohol 10ml)or who are unable to quit drinking during this study or smoker * positive for hepatitis b, hepatitis c, hiv or syphilis * blood pressure is not in the range of "140 \> sitting sbp ≥ 90mmhg, 90 \> sitting dbp ≥ 60mmhg" * pulse rate is not in the range of "95 \> sitting pulse rate ≥ 45bpm (beats per minute)" * ast, alt, total bilirubin over twice of reference range * subjects deemed ineligible by investigator based on other reasons
a study of the intervention effect of a hybrid exercise program on frail elderly

Conditions: Frail Elderly Syndrome

Summary: the declining physical condition of frail elderly is becoming an ugent problem. although the exercise intensity of wu qin xi appears to be low, it is highly effective in the older individuals. inspired by the characteristics and functions of wu qin xi, we designed a brand new exercise intervention training program among frail older people, which incorporates wu qin xi, strength exercises and endurance exercises to improve physical fitness, and even reverse the condition of frailty. furthermore, to improve utility in clinical practice, we innovatively employed machine learning simulations to infer the condition of older adults and predict their level of frailty after the intervention.


Eligibility criteria:
inclusion criteria: 1. a fried frailty phenotype score of 3-5 points; 2. could walk for at least 6 min without support; 3. had not been able to walk in the past year other training. exclusion criteria: 1. people who have a past mental illness or serious psychological issues which make it difficult to obey orders; 2. people who have had neurological disorders within the last six months; 3. people who must regularly participate in other training programs during the study period; 4. people who struggle to walk normally due to significant muscle and skeletal injuries and continuous joint discomfort.

Keywords: frailty exercise intervention
optimal morphine dosing schedule for neonatal abstinence syndrome

Conditions: Neonatal Abstinence Syndrome; Neonatal Opioid Withdrawal; Neonatal Opioid Withdrawal Syndrome

Summary: randomized pilot trial comparing scheduled morphine dosing with a weaning protocol to intermittent morphine dosing on an as-needed basis for newborns with neonatal abstinence syndrome.


Eligibility criteria:
inclusion criteria: * newborn greater than or equal to 35 weeks gestation * intrauterine opioid exposure * signs and symptoms of opioid withdrawal exclusion criteria: * congenital anomalies or suspected genetic condition * co-morbid conditions that require sedation or analgesia due to clinical condition * ongoing need for respiratory support

Keywords: morphine finnegan
effect of the tego connector in preventing tunneled cuffed hemodialysis catheters from dysfunction and/or bacteremia

Conditions: Other Complication of Vascular Dialysis Catheter

Summary: the aim of the trial was to assess whether use of the tego connector was able to reduce the incidence of a composite endpoint of tcc-related dysfunction (tcc-d)or tcc-related bacteremia (tcc-b) in chronic hemodialysis (hd) patients carrying the tego® connector vs controls receiving trisodium citrate 46.7%.

the tego® connector (icu medical, www.icumed.com) is a closed positive pressure system, flushed with 0.9% sodium chloride and attached on the hubs of the tcc. as recommended by the producer, the tego® remains during 3 consecutive hd sessions and is changed every week. by constituting a mechanical barrier, it could be an interesting alternative to reduce the intraluminal contamination and the risk of tcc-b. the tego® connector is supposed to provide an automatic positive displacement of fluid at the end of each tcc flush. this positive pressure could prevent the reflux of blood into the tcc lumen, possibly resulting in tcc-d. as the impact of the tego® connector on tcc-d and tcc-b has never been studied, we conducted a randomized controlled study in our center by comparing the anti-thrombotic and anti-infectious efficacy of the tego® connector to trisodium citrate 46.7% (citralock®, dirinco, www.citra-lock.com) . the global cost of both procedures was also evaluated.

Eligibility criteria:
inclusion criteria: * adult hd patients, prevalent or incident,carrying a tunneled cuffed catheter * tunneled cuffed catheter providing a mean blood flow superior to 250 ml/min * patients having signed an informed consent exclusion criteria: * mature arterio-venous fistula * episode of tcc-related bacteremia 1 week before randomization

Keywords: renal dialyse catheter, indwelling catheter-related infection
weight regain study after bariatric surgery-a pilot project

Conditions: Behavioral; Activity; Weight Loss

Summary: there are three different phases to this study: 1. screening phase to determine if you are eligible to participate in the study. 2. study phase, which will entail diet and activity, exercise and then finally self monitoring goals. 3. end of treatment phase where you will be asked to complete questionnaires.

the purpose of this study is to determine the feasibility of a group treatment program for individuals experiencing weight regain after bariatric surgery and to evaluate the effectiveness of the group treatment program. there is little information on programs to assist patients who experience weight regain after bariatric surgery. this treatment program will focus on behavioral changes and activity.

Eligibility criteria:
inclusion criteria: * weight regain post-rygb of at least 5 kg since reaching their weight nadir. * male or female age 18 - 65. * undergone rygb 12 - 36 month prior. * ability to read, write and understand english. * experienced at least a 25% total weight loss since surgery. * bmi at least 27 kg/m. * weight regain of no more than half of excess body weight. these cases will be referred back to the surgeon. exclusion criteria: * taking weight-suppressing medication (e.g. phentermine, bupropion) * on medications known to cause weight gain * change in smoking status with past three months * change in antidepressant or other psychotropic medication or dosage in past six weeks * change in psychotherapy status in past six weeks * current purging behaviors occurring more than once per week over the past six weeks (vomiting or laxative/diuretic use for the purpose of weight loss * current alcohol abuse or dependence or illicit drug use in past three months * active bipolar or psychotic spectrum disorder * current suicidality or homicidality * severe neuropsychological disease (history of seizure, uncontrolled hypertension * condition associated with cognitive dysfunction (e.g. alzheimer's dementia, other neurological conditions) * medically unstable condition or one which the investigators feel put the participant at risk in the study * functional limitations-not able to walk 2 block without assistance * exercise is contra-indicated (e.g., severe cardiovascular disease, uncontrolled hypertension, hematocrit.\<30%, chronic kidney disease, severe pulmonary disease

Keywords: weight regain group treatment weight loss
efficiency of neurostimulation of tibial nerve in the treatment of low anterior resection syndrome

Conditions: Colorectal Surgery

Summary: the aim of this study is to evaluate the efficiency of the neuroestimulation of the posterior tibial nerve for the treatment of this syndrome. a multicentric, prospective, randomized study will be performed in patients affected with severe lars symptoms. patients will be randomized in two groups: 1. control group- placebo 2. treatment group: neuroestimulation of the posterior tibial nerve


Eligibility criteria:
inclusion criteria: * patients older than 18 and under 75 years who have been undergone anterior resection of the rectum with sphincter preservation for rectal cancer * patients with lars score \> 29 exclusion criteria: * patient with intestinal inflammatory disease * patients with known irritable colon disease * pregnancy patients * patients with others intestinal resection segments different from the rectum * patients with metastatic disease * patient with previous history of posterior tibial neurostimulation or sacral nerve stimulation
atherosclerotic plaque characterization

Conditions: Atherosclerosis

Summary: the purpose of this study is to utilize high-resolution cmr carotid imaging for the characterization of carotid wall volumes and plaque content in patients with clinical significant carotid atherosclerosis. patients who are scheduled to undergo an imaging procedure will be recruited from the cath lab. upon enrollment, blood samples conventional and genetic profiling will be collected. for patients undergoing a carotid endarterectomy, tissue from the carotid vessel will be collected during their procedure. comparison of the mr images with tissue and/or blood samples will be made. length of time in the study will be approximately 1 day. there will be no study-related patient follow-up.


Eligibility criteria:
inclusion criteria: * age range \>17 years of age * surgical carotid artery disease * provide written informed consent and authorization for use/disclosure of phi exclusion criteria: * history of carotid trauma * history of middle or large vessel vasculitis * refusal to provide written informed consent and authorization for * use/disclosure of phi

Keywords: atherosclerosis subjects diagnosed with atherosclerosis
cholesterol lowering effect of cardio-complement, an ayurveda formulation

Conditions: Hypercholesterolemia

Summary: the aim of this feasibility study was to assess the lipid-lowering effects and safety of a ayurveda formulation containing terminalia arjuna, withania sominifera, garcinia cambogia and piperine (as bioenhancer)

the covid-19 related lockdowns severely affected the healthcare in india, specially in second wave of covid-19. this research presents the applicability of ayurveda formulation to analyze the impact on lipid profile during the lockdown. patients with hyperlipidemia who referred to gyansanjeevani were recruited. all participants were enrolled in the study after a complete physical examination and medical history remotely over the virtual secure platform.

Eligibility criteria:
inclusion criteria: * age between 18 and 65 years * bmi between 18.5 and 40 kg/m2 * total cholesterol \>180 mg/dl * no clinically significant medical history * willing to participate to the study by complying with the protocol * able to provide written informed consent exclusion criteria: * metabolic disorder such as diabetes, uncontrolled thyroidal trouble or other metabolic disorder, * severe chronic disease * history of ischemic cardiovascular event, * uncontrolled hypertension * under treatment or dietary supplement which could affect study parameter

Keywords: ayurveda cholesterol cardiovascular diseases hyperlipidemia
outcomes in lower extremity soft tissue sarcoma patients after limb salvage

Conditions: Limb Salvage

Summary: this study aims to: 1. validate the finnish version of the musculoskeletal tumor society scale and the toronto extremity salvage score lower extremity sections and to 2. assess the functional ability and health-related quality of life (hrqol) of lower extremity sarcoma patients who have undergone limb salvage surgery.

the first purpose of this study is to validate the finnish version of the musculoskeletal tumor society scale and the toronto extremity salvage score upper extremity sections. the second purpose is to chart the functional capabilities and health-related quality of life (hrqol) of upper extremity sarcoma patients who have undergone limb salvage surgery with local or free flaps. patient hospital records are retrospectively reviewed to chart the demographic and clinical data. the recruitment of patient takes place at the outpatient clinic of department of oncology, helsinki university hospital. the study includes a cross-sectional assessment at one year follow-up with five validated questionnaires. a follow-up is conducted three years after surgery in the outpatient clinic.

Eligibility criteria:
inclusion criteria: * lower extremity soft tissue sarcoma locating in between hip/gluteus to foot * no metastasis at the time of diagnosis * undergone limb salvage surgery * a minimum of 1 year follow-up * written consent * age \> 18 exclusion criteria: * age \<18 * no limb-salvage surgery due to sarcoma

Keywords: [e04.100.814.603]
evaluation of the analgesic effect of ropivacaine in topical use at the thin skin graft donor site

Conditions: Graft Pain

Summary: the aim of the study is to evaluate of the analgesic effect of ropivacaine in topical use at the thin skin graft donor site. for patient needing a thin skin graft \< 320 cm2, randomization will be done in 2 groups, one receiving the standard treatment (20 ml of physiologic serum) during the surgical intervention in topical use to recover an alginate dressing (algosteril)and the other receive 20 ml of naropein during the surgical intervention on alginate dressing. the hypothesis of the study is the administration of ropivacaine will decrease the post-operative pain compared to physiologic serum


Eligibility criteria:
inclusion criteria: * patient older than 18 years old * patient needing a thin skin graft \< 320 cm2 and which is possible on the thigh * patient who read the information letter and signed the informed consent * patient affiliated at a social security system * effective contraceptive method for more than 3 months for women of childbearing age exclusion criteria: * contraindication to one of the medicine used (allergy, intolerance, potential drug interaction) * treatment by classii or iii of analgesics or analgesic dose of aspirin(\>500mg per day) at the inclusion or randomization time * preoperative eva\>0 at the skin graft donor site on the thigh * sensory disturbances of the lower limbs * cognitive disturbances not allowing investigations * pregnant or lactating women * people deprived of discernment * people deprived of their liberty by judicial or administrative authority * protected adult (guardianship or trusteeship)

Keywords: skin graft donor site