Kornimate/medical-research-clean huggingface dataset:
neurovascular coupling and autonomic neuropathy in type 2 diabetes

Conditions: Type 2 Diabetes; Cardiovascular Autonomic Neuropathy

Summary: diabetes is a growing global health care challenge. diabetes patients may also suffer from cardiovascular autonomic neuropathy (can) which may affect cerebral perfusion. the main purpose of this project is to investigate the association between can and disturbances in the neurovascular coupling in type 2 diabetes patients. moreover, the purpose is also to investigate coherence between can and the enteric nervous system. finally, this project aims at delineating microstructural changes in the brain tissues as a consequence of can.


Eligibility criteria:
inclusion criteria: * a diagnosis of type 2 diabetes (patients) * age between 50-70 years (all) * presence of can as diagnosed by cardiovascular reflex tests with two or three pathological results (patients with can only) * exclusion of can as diagnosed by cardiovascular reflex tests with no pathological results (patients without can and hc only) exclusion criteria: * participants receiving treatment with direct effects on noradrenergic or cholinergic signaling (for example beta-blockers, tricyclic antidepressants, ssri's) (all) * acute infections (all) * thyroid disease (all) * substance or alcohol abuse (all) * atrial fibrillation or flutter (all) * respiratory failure (all) * participants in active laser treatment for retinopathy, will be excluded from the valsalva test (patients) * non-diabetic causes of neuropathy including a medical history of vitamin b12 deficiency, folic acid deficiency, rheumatoid arthritics, amyloidosis, hiv, syphilis, borreliosis, drug induced neuropathy and neuropathy caused by toxins (all) * claustrophobia (all) * implanted pacemakers or remaining pacemaker electrodes (all) * previous heart or brain surgery with use of metal clips (all) * any form of non-mr-compatible implants * non-compliance with the study protocol as judged by the investigators (all) * concurrent participation in an intervention study (patients) * participants who by judgments of the investigator, is incapable of participating (all)
oxygen saturation monitoring during surgery

Conditions: Sleep Apnea, Obstructive

Summary: patients with obstructive sleep apnea (osa) have cyclical patterns of lower blood oxygen during sleep because of repeated episodes of upper airway obstruction that cause their breathing to stop. when these patients have surgery, anesthetic drugs may worsen these patterns of lower blood oxygen. this study monitors ten patients at high risk for osa and ten patients at low risk for osa during surgery. patterns of lower oxygen saturations should arise in the high risk group but not the low risk group.

patients with obstructive sleep apnea (osa) have episodes of upper airway obstruction during sleep which have been shown to be accompanied by multiple oxygen desaturations followed by short recovery intervals until rising paco2 causes sleep disruption/rescue arousal. in the postoperative and conscious sedation arena, these patterns can deteriorate from a stable pattern to a severely unstable pattern which may go unrecognized and lead to an adverse event (respiratory/cardiac arrest; death). anesthesia and the higher consumption of analgesics produce a profound reduction in pharyngeal tone, a dampening of both chemoreceptor sensitivity and arousal/rescue response. thus the first 48 hours post operatively presents a vulnerable period. respiratory disturbances are more prominent - respiratory arrest and hypopnea being the main adverse occurrences during this period. an algorithm has been developed that monitors saturation and indicates repetitive reductions in airflow through the upper airway and into the lungs. presence of this pattern in the procedural sedation patient population has not been tested for its prevalence. this study will monitor patients during surgery to determine if this pattern occurs in this hospital setting.

Eligibility criteria:
inclusion criteria: * age greater than 21 years * patients scheduled for a procedure that requires analgesia and/or sedation by any route (intravenous, intramuscular, oral, epidural or intrathecal). * patients with an anticipated length of sedation greater than or equal to one hour. * patients in the asa category i through iii. * patients who only receive propofol, benzodiazepines, and opioids. exclusion criteria: * age less than 21 years * patients whose room air oxygen saturation is \<90% * patients receiving post-operative positive airway pressure support * previous allergic/contact reactions to adhesives * chf * moderate or severe valvular disease * tia/cva * carotid stenosis or endarterectomy * anemia (hct if available \< 30%) * pulmonary hypertension * dialysis * pregnancy * patients unable to give informed consent

Keywords: obstructive sleep apnea pulse oximetry
neural correlates of movement disorders associated with prrt2 related paroxysmal kinesigenic dyskinesia - an ancillary study of amedyst research

Conditions: Paroxysmal Dyskinesia

Summary: the main objective of this study is to investigate in real-time the neuronal correlates of paroxysmal dyskinesia episodes related to the prrt2 mutation within this subgroup of patients (who can control paroxysmal dyskinesia episodes), and more specifically, the pathological role of the reciprocal influence between the striatum and the cerebellum in paroxysmal dyskinesia episodes.

we propose to conduct a study using functional mri and eeg in this subgroup of patients with the prrt2 mutation capable of triggering paroxysmal dyskinesia episodes. for both modalities, we aim to perform an analysis of the activation of regions involved in the occurrence of abnormal movements during the prodromal phase when the acquisition is not affected by movements. using these techniques, we will also investigate the regions involved in judging control over action during phases where abnormal movements may occur before the episode (when the system is excitable) and when it is no longer possible during the refractory period (when the system is no longer excitable). additionally, we plan to conduct a targeted analysis of functional connectivity in the striato-cerebellar pathway before the episodes (when the system is excitable) and after the episodes during the refractory period (when it is no longer excitable). our hypotheses are as follows: 1) there is a relationship between the cerebellum, the basal ganglia and the cortex implicated in the abnormal movements associated with the prrt2 mutation; 2) the frontal or prefrontal cortex, the cerebellum and basal ganglia are involved in the inhibition of unwanted movements; 3) there is a distortion in the sense of control over action related to paroxysmal dyskinesia episodes.

Eligibility criteria:
inclusion criteria: male or female individuals with dystonic disease carrying a prrt2 mutation and demonstrating the ability to control paroxysmal dyskinesia episodes. affiliated with a health insurance system or a beneficiary of such a system. individuals aged 18 to 75 years. signature of informed consent exclusion criteria: individuals under guardianship. individuals not residing in france. individuals unable to comply with protocol constraints (compliance with visit schedules and ability to perform required tasks). individuals undergoing an exclusion period for another research study. contraindications to mri

Keywords: dyskinesia voluntary movements cerebellum basal ganglia cortex fmri eeg
pulsed dye laser and intense pulsed light configured with different wavelength bands in improving erythematotelangiectatic rosacea

Conditions: Erythematotelangiectatic Rosacea

Summary: pulsed dye laser(pdl) and intense pulsed light(ipl) has been widely used in improving rosacea. to compare the efficacy and safety of pdl and ipl configured with different wavelength bands(delicate pulsed light, m22 590, m22 vascular filter) in the treatment of rosacea, we designed a prospective, randomized controlled trial. we hope to make a comparison between pdl and ipl,between broad-spectrum ipl and narrow-spectrum ipl, between single-band ipl and dual-band ipl, and also provide clinical basis for clinicians and patients to develop individualized treatment plans.

rosacea is a chronic skin condition characterized by erythema, inflammatory papules, pustules and telangiectasias, which typically occur on the face of middle-aged adults, especially fair skinned. the disease can lead to social stigmatization and may significantly reduce the quality of life of patients. for erythematous lesions and telangiectasia, intense pulsed light (ipl) therapy and lasers are popular treatmen option. lasers and non-coherent intense pulse light sources (ipl) are based on the principle of selective photothermolysis. the target chromophore in vascular lesions is the oxyhemoglobin present in the red blood corpuscles (rbcs) which circulates in the blood vessels. pulsed dye lasers (pdl) use a wavelength of 595 nm and is the gold standard of vascular lesion treatment. a common complication is post treatment purpura which appears immediately and can last for 7-14 days, which may be cosmetically unacceptable. the intense pulsed light (ipl) produces a non-coherent light beam with a spectrum of wavelengths from 500 to 1200 nm. cut-off filters at 515, 550, 570, 590 nm are used for vascular lesions. to compare the efficacy and safety of pdl and ipl configured with different wavelength bands(delicate pulsed light, m22 590, m22 vascular filter) in the treatment of rosacea, we designed a prospective, randomized controlled trial. we hope to make a comparison between pdl and ipl,between broad-spectrum ipl and narrow-spectrum ipl, between single-band ipl and dual-band ipl, and also provide clinical basis for clinicians and patients to develop individualized treatment plans.

Eligibility criteria:
inclusion criteria: age of at least 18 years; according to the rosacea diagnostic criteria established by the nrsec in 2002, be diagnosed as erythematotelangiectatic rosacea; rosacea clinical score is between 9 and 12; fitzpatrick skin type iii and iv; exclusion criteria: there was infection in the treatment site sunburn history within 1 month; received oral isotretinoin or laser treatment in the past 3 months received chemical peeling 1 month before the study pregnancy or breast-feeding. those who are receiving other treatment for rosacea, such as topical and oral drugs;

Keywords: pulsed dye laser，intense pulse light
simvastatin effect on inflammation and endothelial function after myocardial infarction

Conditions: Myocardial Infarction; Inflammation; Endothelial Dysfunction

Summary: during myocardial infarction, inflammatory response may negatively influence ventricle wall remodeling as well as endothelium-dependent vasomotor function in the coronary and systemic arterial systems. statins have been consistently proved to attenuate inflammation and improve endothelial function. in this study, we tested the effect of different doses of statin on inflammatory response and endothelium-dependent vasodilation.

during acute coronary syndromes (acs), the generation of inflammatory mediators negatively influences arterial wall remodeling and the endothelium-dependent vasomotor function in the coronary and systemic arterial systems. the intensity of this inflammatory upregulation is strongly related to the incidence of recurrent coronary events. high dose potent statins can rapidly reduce plasma levels of cholesterol-rich lipoproteins and inflammatory activity in subjects during acs. by inference, it is plausible to hypothesize that these effects during the acute phase of myocardial infarction may influence the post-discharge endothelial dysfunction. so far, data is unavailable to verify this assumption or to define the potency required for such statin anti-inflammatory effect in myocardial infarction patients. the present study aim to investigate the role of statin dose on the time-course of the inflammatory response during the acute phase of myocardial infarction and its late effect on endothelium-dependent arterial dilation.

Eligibility criteria:
inclusion criteria: * less than 24 hours after the onset of mi symptoms * st-segment elevation of a least 1 mm (frontal plane) or 2 mm (horizontal plane) in two contiguous leads * myocardial necrosis, as evidenced by increased ck-mb and troponin levels exclusion criteria: * use of statins for at least 6 months prior the myocardial infarction

Keywords: myocardial infarction inflammation endothelial dysfunction
an assessment of the occurrence of hypothyroidism in patients treated with rai for hyperthyroidism.

Conditions: Nodule Solitary Thyroid; Toxic Multinodular Goiter; Radioactive Iodine-Induced Hypothyroidism

Summary: low raiu in patients with hyperthyroidism represents a common obstacle in the treatment with rai. therefore, a higher dose of rai must be administered to cure hyperthyroidism in these patients. if we treat patients with thiamazole before starting rai treatment, serum tsh will rise and result in an increase in iodine uptake by the thyroid gland. by doing so, the dose of rai to be administered might be lowered to achieve similar therapeutic efficacy. in the past, either calculated or fixed doses of 131i have been used to treat hyperthyroidism. the supposed advantage of a calculated dose compared to a fixed dose is the lowering of hypothyroidism frequency. however, various research papers have contradicted this statement. antithyroid drugs and rai therapy have been widely used in the past, either in combination, or independent from one another. this has been done primarily in older patients, to reduce the risk of exacerbation of hyperthyroid symptoms after initiation of rai. the use of propylthiouracil has been shown to decrease the response rate after rai due to radioprotective effects. the use of methimazole and carbimazole did not have a negative effect on treatment failure, as long as the medication was discontinued various days before rai administration. although this statement is contested in other studies. it is interesting to evaluate retrospective data of patients treated with rai to evaluate prognostic factors of treatment respons and post rai hypothyroidism.


Eligibility criteria:
inclusion criteria: * hyperthyroid patients, either subclinical or overt, who have undergone rai treatment in the period of 2005-2015. exclusion criteria: * prior use of l-thyroxine * prior thyroid surgery * prior rai treatment * patients with thyroiditis
validation of the diabetes deep neural network score for diabetes mellitus screening

Conditions: Diabetes

Summary: the validation of the diabetes deep neural network score (dnn score) for screening for type 2 diabetes mellitus (diabetes) is a single center, unblinded, observational study to clinically validating a previously developed remote digital biomarker, identified as the dnn score, to screen for diabetes. the previously developed dnn score provides a promising avenue to detect diabetes in these high-risk communities by leveraging photoplethysmography (ppg) technology on the commercial smartphone camera that is highly accessible. our primary aim is to prospectively clinically validate the ppg dnn algorithm against the reference standards of glycated hemoglobin (hba1c) for the presence of prevalent diabetes. our vision is that this clinical trial may ultimately support an application to the food and drug administration so that it can be incorporated into guideline-based screening.


Eligibility criteria:
inclusion criteria: * age \> 18 years old * participants without a prior diagnosis of dm * participants with a recently measured hba1c one month before enrollment or scheduled to undergo a hba1c measurement within one month after enrollment * participants not scheduled for hba1c and are willing to undergo a lab measured hba1c * participants without risk factors for dm * participants with \> 1 of the following risk factors for dm: * age \> 40 years old * obesity (bmi \> 30) * family history: any first degree relative with a hx of dm * lifestyle risk factors (exercise, smoking, and sleep duration) * ownership of a smart phone * able to provide informed consent * willingness to provide ppg waveforms exclusion criteria: * participants with a history of dm * participants with a prior hba1c \> 6.5% * inability to collect ppg signals (digit amputation, excessive tremors, etc) * lack of ownership of a smartphone * inability or unwillingness to consent and/or follow requirements of the study
current intensity for the obturator nerve block

Conditions: Bladder Tumor

Summary: the purpose of the present study was to find out the difference in current intensity required for nerve stimulation according to the presence or absence of neuromuscular blockade during the obturator nerve block procedure for turp.

during the transurethral resection of bladder tumors (turbt) procedure under spinal anesthesia, the obturator nerve block is required to prevent the accidental movement of adductor longus muscles by electrical stimulation. however, during general anesthesia, the contraction of the adductor longus muscle would be lost due to deep neuromuscular blockade. however, some reports showed that the contraction of the adductor longus muscle occurs even in the deep neuromuscular blockade. the current intensity for the nerve stimulation during nerve block is 0.3--0.5 ma when the needle tip is near the nerve. however, it is still unknown what current intensity is required to show the contraction of the adductor longus muscle when the patient is in a deep neuromuscular blockade. therefore, in this study, investigators aimed to determine the difference in current intensity required for nerve stimulation according to the presence or absence of neuromuscular blockade during obturator nerve block for turp. in addition, investigators aimed to determine that the obturator nerve block is required during the turp procedure in patients with deep neuromuscular blockade during general anesthesia.

Eligibility criteria:
inclusion criteria: * patients undergoing turp procedure exclusion criteria: * patients with anatomical or functional anomaly in the upper airways * patients with neuromuscular disease * patients with hip joint disorders * bmi of \ 30.0 kg/m2

Keywords: transurethral resection of bladder obturator nerve nerve block neuromuscular blockade anesthesia, general
hospitalisations of teenagers and young adulthoods in mayotte after consumption of an illegal drug called " chimique ", which substances are incriminated ? : homachi

Conditions: Drug Abuse

Summary: the study aims (i) to identify which substances leading to hospitalizations at mayotte are also called "chimique" and (ii) to correlate these substances with clinical pictures in order to favor a better approach of the treatments.

the ceip-a of bordeaux (in charge of french overseas departments) has been commissioned by the mild\&ca in 2015 to reinforce the links between local caregivers and the addictoviligance's inquieries. in particular, the ceip-a has been alerted about a drug called " chimique " in mayotte, leading to many hospitalizations. most of the patients are less than 18 year old or are young adulthoods. for all patients who have agreed to participate in this study, the remainder of the blood sample will be reused for a drop of blood on blotting paper; the remainder of the remainder will be stored in the heparinized tube. medical data collected in the emergency department will also be collected. all the data will be analyzed by the pharmacology and toxicology laboratory of the bordeaux university hospital

Eligibility criteria:
inclusion criteria: * patients hospitalized in the emergency department of the mayotte hospital center after taking a chemical or other psychoactive substance and for whom a blood test is required; * age ≥ 14 years. exclusion criteria: * patient without parental authority for minor patients aged 14yrs; patient not included in the exception article 59 of the law of january 6th, 1978 modified for patient aged 15yrs and older

Keywords: drug abuse chimique high resolution mass spectrometry
a study of the efficacy and safety of ica-17043 (with or without hydroxyurea) in patients with sickle cell anemia.

Conditions: Sickle Cell Disease; Sickle Cell Anemia

Summary: ica-17043 is being developed for the chronic treatment of patients with sickle cell disease (scd) in both adults and children. ica-17043 is a potent and specific inhibitor of a channel in human red blood cells (rbcs) that blocks rbc dehydration. ica-17043 is expected to inhibit rbc dehydration and thus should prevent or delay the sickling process. by reducing sickled cells, an improvement in anemia, a reduction in painful crises, and ultimately, less end-organ disease is anticipated.


Eligibility criteria:
inclusion criteria: * homozygous (hbss) sickle cell anemia * otherwise healthy (based on medical history, physical examination, 12-lead ecg, and clinical laboratory tests) * patients may be receiving hydroxyurea, but must have been dose stabilized for at least 3 months * patient has a history of at least one acute vaso-occlusive event requiring hospitalization exclusion criteria: * patient participating in a chronic transfusion program * patient having a total hemoglobin of \ 10.0 g/dl * patient having a hba \> 10% * patient considering undergoing an elective surgery * patient taking prohibited medications such as epoetin, warfarin, etc. * patient who has had previous gastrointestinal surgery, except cholecystectomy or appendectomy * patient with significant active cardiovascular, neurologic, endocrine, hepatic, or renal disorders unrelated to sickle cell anemia

Keywords: sickle cell anemia sickle cell disease anemia ica-17043 senicapoc
do text message reminders increase preoperative exercise in obesity surgery candidates?

Conditions: Perioperative Care; Bariatric Surgery; Obesity

Summary: preoperative exercise has been shown to improve physiological and functional capacity in patients undergoing abdominal surgery to prepare them for the stress of surgery. patients undergoing bariatric surgery are advised to partake in regular preoperative exercise. in the setting of bariatric surgery, as well as preparing patients for the stress of surgery, it is also thought to increase the likelihood that they will exercise postoperatively. however, compliance to this advice is extremely low. text-message interventions have been shown to improve compliance to other lifestyle interventions. the investigators will compare the rate of compliance to preoperative exercise prior to bariatric surgery in patients who receive a daily text message to those who do not. the investigators will also compare weight loss.


Eligibility criteria:
inclusion criteria: * patients having laparoscopic sleeve gastrectomy at manukau surgery centre * operation used primarily for the treatment of morbid obesity exclusion criteria: * operation not performed at manukau surgery centre * patient does not have a mobile phone which can receive text messages
four-week omeprazole treatment of non-erosive reflux disease in a japanese population

Conditions: Non-erosive Reflux Disease

Summary: the purpose of this study is to study safety and efficacy of omeprazole standard treatment in a japanese non-erosive reflux disease population.


Eligibility criteria:
inclusion criteria: * patients who identified their predominant symptom as heartburn and were classifiend as grande m or n according to hoshihara's modofied version of los angeles classification at esophagogastroduodenoscopy. exclusion criteria: * patients with any ongoing gastrointestinal bleeding at the time of esopgahogastroduodenoscopy, patients with any history of erosive esophagitis or any other major diseases or concommittant drugs likely to interfere with the evaluation of this study