Kornimate/medical-research-clean huggingface dataset:
preventing drug abuse among hispanic adolescents

Conditions: Drug Abuse

Summary: the planned research aims to delay the onset of drug use and reduce harmful use and abuse among hispanic youths. the culturally-tailored prevention program will be delivered to youths by computer. over 5 years, the program will be developed and tested in a randomized clinical trial. the intervention program will include 10 initial sessions, followed by annual booster sessions. outcome measurements will involve baseline, post-intervention, and three annual follow-up data collections. the study's primary hypothesis is that rates of 30-day alcohol and drug use will be lower among participants assigned to receive the intervention. if proven to be efficacious, the program will be revised and disseminated nationally.

america's largest ethnic minority group, hispanics are also a youthful population: one-third of hispanic americans are less than 18 years old. unfortunately, young hispanic americans are an at-risk population more likely than their majority culture peers to drop out of school, become involved in the criminal justice system, fall prey to violence, and face lifelong economic problems. hispanic youths are also at risk for early drug use and subsequent harmful use and abuse. as early as eighth grade and relative to their black and white peers, hispanic adolescents report higher rates of most harmful substances. drug use continues to pose problems for hispanic youths throughout adolescence and into adulthood.

Eligibility criteria:
inclusion criteria: * 12 to 15 years old * hispanic ethnicity exclusion criteria: * none

Keywords: drug abuse
study on serum zinc and selenium levels in epileptic patients

Conditions: Generalized Epileptic

Summary: this study was carried out with the purpose of evaluating zinc and selenium levels in serum of epileptic patients and compare with normal individuals.

forty patients aged 18 to 50 years visiting vali-asr hospital in arak, i.r. iran, who were diagnosed with generalized form of epilepsy by a neurologist for the first time were recruited as cases. the control group (n=40) was selected from healthy individuals, in whom no disease was diagnosed until this study, and were matched to the case group by age, sex, and economical status.

Eligibility criteria:
inclusion criteria: new generalized and single epileptic cases patients who accept and sign the approval form of ethical committee non smoker, no trauma, no use of selenium supplement, no use of zinc supplement, no use of vitamin a supplement, no use of vitamin d supplement, no weight loss, no diarrhea, no addiction, no alcohol consumption, no use of certain medications, exclusion criteria: presence of above criteria as well as, generalized and single epileptic cases under treatment

Keywords: zinc selenium serum epilepsy antioxidants
obesity management for kidney transplantation: ok-transplant 2

Conditions: Obesity; Chronic Kidney Disease

Summary: ok-transplant 2 is a vanguard study for a large randomized, pragmatic, open-label trial. we will randomize participants with obesity, high-risk ckd/dialysis who are hoping for lose weight for the purpose of kidney transplant. subjects will either be enrolled on a virtual weight management program or continue their usual care.

obesity is well-recognized as an independent risk factor for chronic kidney disease (ckd) including end-staged kidney disease (eskd). in people with eskd, obesity can preclude access to lifesaving kidney transplantation. of solid organ transplant programs in canada, 80% exclude people with obesity (based upon body mass index or bmi), due to a potential risk of perioperative complications and post-transplant mortality. losing weight for kidney transplantation can, however, be extremely difficult. medications that can promote weight loss in other populations including glucagon-like peptide 1 receptor agonists (glp-1ra; liraglutide, semaglutide, and dulaglutide) and glucose-dependent insulinotropic polypeptide (gip-1ra)/glp-1ras (tirzepatide), have not been studied in devoted trials of advanced ckd participants, and their efficacy and safety remain unclear. nutritional advice is often very difficult to follow when trying to balance kidney and diabetes diets (e.g. potassium), and if diets are too restrictive, there may be protein-energy wasting which could be detrimental to patients. people with high-risk ckd frequently live with functional impairment which can limit exercise. weight loss programs can be cost prohibitive to those who are already socioeconomically disadvantaged. a vanguard is needed before a large, multicentered rct: a feasibility study will allow us to ensure that we can recruit a sufficient sample of participants into our trial, that our trial processes are inclusive, and that they are acceptable to patients. in the vanguard phase of our trial, we will answer the following questions: 1. is participant recruitment into a large multi-centered trial feasible? 2. will participants remain adherent to their assigned treatment arm over 26 weeks of study? 3. will participants find our program acceptable? 4. will safety events preclude us from testing our intervention in a larger rct?

Eligibility criteria:
inclusion criteria: * adults aged 18 years or older * bmi \&gt; 35 kg/m\^2 * \&gt;10% risk of eskd requiring renal replacement therapy over 2 years or receiving dialysis exclusion criteria: * known contraindication to a glp-1ra * type 1 diabetes * current use of more than the starting dose of semaglutide, liraglutide, or dulaglutide * no access to semaglutide via drug coverage * absolute contraindication to kidney transplant * pregnant, breastfeeding or planning to become pregnant

Keywords: weight management transplant glp-1ra pilot study registries pragmatic
guided self-management intervention targeting fatigue in rheumatic inflammatory diseases

Conditions: Fatigue; Inflammatory Rheumatism

Summary: fatigue is common and debilitating in rheumatic inflammatory diseases as for other chronical medical conditions. the purpose of this study is to develope and evaluate a cognitive behavioural intervention targeting fatigue. the aim of the intervention is to improve fatigue self-management by changing behavioral and cognitive factors contributing to perceived fatigue. levels of fatigue, depressive symptoms and self esteem will be measured before, after and three months after the intervention.


Eligibility criteria:
inclusion criteria: • men and women over 18 years with inflammatory rheumatic diseases and fatigue at department of rheumatology, diakonhjemmet hospital exclusion criteria: * unable to provide informed consent * unable to read and understand norwegian * unable to complete a survey

Keywords: fatigue inflammatory rheumatism coping self-efficacy
cardiometabolic response to a sodium-bicarbonated mineral water

Conditions: Dyslipidemia

Summary: the effects of consuming a sodium-bicarbonated mineral water rich in bicarbonate, sodium, chloride, lithium and silicon are studied in humans. the aim of this assay was to determine whether the consumption of this water as part of the usual diet, reduces cardiometabolic risk factors in adult men and women.


Eligibility criteria:
inclusion criteria: * healthy adults, men and women \>18 and ≤ 45 years * total-cholesterol \> 200 mg/dl and \< 300 mg/dl exclusion criteria: * age \ 45 years * total-cholesterol ≥300 mg/dl * triglycerides \> 250 mg/dl * total-cholesterol / hdl-cholesterol \> 6 * being a usual consumer of carbonic mineral water * bmi \ 30 kg/m2 * diabetes * hypertension or digestive, liver or renal disease * eating disorders * being under medication that could affect lipid metabolism * consumption of functional foods that could affect lipid metabolism (food containing n-3 fatty acids or phytosterols)
immunonutritional supplement after total gastrectomy in patients with stage iii gastric cancer

Conditions: Stage III Gastric Cancer

Summary: gastric cancer patients with stage iii will be randomized to immune nutrition support or control group at discharge after total gastrectomy. patients will receive 6 months of immune nutrition support or normal diet after discharge. the primary and secondary outcomes will be collected.

gastric cancer patients with stage iii after total gastrectomy at discharge, if she/he has nutrition risk (nrs2002≥3), then she/he will be randomized to immune nutrition support (ins) or control (c) group after discharge. in the ins group, in addition to diet, and patients will also consume two bottles per day of a high-calorie, high-protein ons and three capsules of fish oil lasted for 6 months. in the c group, patients will receive normal diet. both groups will receive nutrition counseling. the primary and secondary outcomes will be collected.

Eligibility criteria:
inclusion criteria: 1. informed consent of patients or their legal representatives to participate in this study 2. consecutive adult (≥18 years) patients underwent radical gastrectomy (total gastrectomy) with pathological tnm stage iii 3. nutrition risk screening (nrs) 2002≥3 at discharge 4. eastern cooperative oncology group (ecog) score of 0-2 at discharge exclusion criteria: 1. unable to oral or consume ons 2. has received neoadjuvant chemotherapy 3. pregnancy 4. palliative surgery or gastric stump cancer or borrmann type iv 5. oral anticoagulants cannot be stopped; congenital acquired immune deficiency disease 6. serious cardiovascular disease including chronic heart failure, angina pectoris, myocardial infarction, arrhythmias (such as atrial fibrillation), or uncontrolled hypertension 7. severe liver and kidney diseases including active hepatitis, cirrhosis, and uremia 8. diabetes has developed complications or uncontrolled by medications 9. previous use of drugs affecting immune function 10. previous use of fish oil capsule \> 2 times / week or contraindications to fish oil capsule 11. motor system diseases cannot complete grip strength measurement and 5-time chair stand test

Keywords: oral nutritional supplement immunonutrition long-term survival
facilitating motor skill learning in parkinson's disease

Conditions: Parkinson Disease

Summary: the study is designed to assess the effects of aerobic exercise on motor learning in parkinson patients. specifically, the investigators examine whether a single bout of moderate intensity aerobic exercise, performed immediately before task practice, facilitates the acquisition and retention of a motor skill. in a cross-over design, participants will be randomly allocated to either the intervention group (aerobic exercise before motor learning) or control group (rest before motor learning).

parkinson's disease is a progressive neurodegenerative disorder that is characterized by motor control impairments, such as gait disturbances and postural instability. beneficial effects of exercise are attributed to mechanisms of neuroplasticity, and task-specific motor training is consequently considered to be a motor learning process. while motor learning is preserved in persons with parkinson's disease, slower acquisition rates and reduced retention have been reported compared to healthy individuals. thus, it is crucial to identify strategies to enhance motor learning in people with parkinson's disease. recent studies have accumulated evidence to show that aerobic exercise can facilitate motor skill learning. however, these observations are limited to healthy individuals and have not been addressed in individuals with neurologic conditions. the present study is designed to assess the effects of a single bout of moderate intensity aerobic exercise on a motor skill learning task in patients with parkinson's disease. in a cross-over design, participants will be randomly allocated to one of two groups. both groups will practice balancing on a specific stability platform (motor learning task). the experimental group will additionally perform a bout of aerobic exercise (cycle ergometer) immediately before the motor learning task, while the control group will rest before practice. subsequently, the acquisition and one-day retention of the motor learning task will be examined.

Eligibility criteria:
inclusion criteria: * parkinson's disease stage 1-3 on hoehn \& yahr scale * ability to stand unaided and walk without an assistive device * stable medication during the study period exclusion criteria: * on-off and wearing-off phenomena * unstable medical or psychiatric illness * clinically relevant cardiovascular or orthopaedic disease * severe polyneuropathy * cognitive impairment * smoking \> 10 cigarettes/day * caffeine \> 6 cups of coffee/day * alcohol \> 50 g (two glasses)/day

Keywords: parkinson's disease motor learning aerobic exercise cardiovascular exercise balance postural instability motor skill
autologous bone marrow mononuclear cells therapy in diabetic lower limb ischemia

Conditions: Diabetes; Lower Limb Ischemia

Summary: this study is to evaluate the safety and efficacy of autologous bone marrow mononuclear cells transplantation in diabetic patients with lower limb ischemia.

diabetic lower limb ischemia as severe complication of diabetes influences the life quality of patients and currently the effective treatment for the disease is lacking. bone marrow mononuclear cells have been proved to have multiple functions including the differentiation and proliferation. in animal model, bone marrow mononuclear cells could induce angiogenesis and may have therapeutic usage for ischemia disease. the investigators thereby design the study to investigate the possible therapy of diabetic lower limb ischemia with autologous bone marrow mononuclear cells. patient with diabetic lower limb ischemia was treated with colony stimulating factor for improvement of bone marrow hematopoiesis. then bone marrow was taken and mononuclear cells were isolated with deleting erythrocyte by density gradient centrifugation. bone marrow mononuclear cells were transplanted into ischemia regions of lower limb through intramuscular injection. the investigators investigated the safety of the therapy with life signs like temperature, pulse, blood pressure, routine analysis of blood and urine etc. post the transplantation. and the efficacy was evaluated with the measurement of ulcer size, rest pain score, cold sensation score, resting abi, resting tcpo2, collateral vessel score and skin microcirculation.

Eligibility criteria:
inclusion criteria: 1. fontaine's stage 2-4 or resting abi \<0.7 2. age between 20 and 80 years old 3. sign informed consent, voluntary subjects 4. diagnosis of diabetic lower limb ischemia exclusion criteria: 1. poorly controlled diabetes (hba1c\> 7.0%) and proliferative retinopathy (iii-iv stage) 2. malignancy history in the past five years or serum level of tumor markers elevated more than doubled 3. severe heart, liver, kidney, respiratory failure or poor general condition can not tolerate bone marrow mononuclear cells transplantation 4. serious infections (such as cellulitis, osteomyelitis, etc.) 5. pregnant female, or reproductive age female who wants to give birth throughout the course of the study 6. life expectancy less than half a year
fluoride release,compressive strength and clinical performance of a bioactive restorative material in art

Conditions: Dental Caries

Summary: the study will be two parallel group, triple blinded randomized controlled clinical trial that based on consort (consolidated standards of reporting trials) guideline .the selected participants according to inclusion and exclusion criteria will be randomly allocated in two groups using (research randomizer program) .

blinding all participants don't know the type of received restorative material (activa kids or high -viscosity gi restorative material) and the outcome will be evaluated by a examiner other than operator who doesn't know the type of received restorative material also. study setting the study will be performed at pediatric department and dental public health department of faculty of dentistry, ain shams university, and at the institute of graduate studies and research, ain shams university. sample size: 60 participants recruitment/setting the all participants of this study have been selected after complete clinical examination has been done with full medical and dental history , history of medications and history of hospitalization. in patients who receive dental treatment as an usual care in clinics of pediatric dentistry and dental public health department at faculty of dentistry, ain-shams university. informed consent designed to include all data about dental procedures in this study and clear more details about time consuming in the procedure and follow up visits, used materials and adverse event of this procedure . all participants have the wright to withdraw from this study at any time .the consent will be assigned from each patient by the patient's parents or guardians after explanation of the study. the full mouth rehabilitation will be performed by postgraduate student registered at the master degree at the pediatric dentistry and dental public health department faculty of dentistry, ain- shams university all subjects receive instructions on oral health, particularly in relation to oral hygiene and sugar consumption

Eligibility criteria:
inclusion criteria: 1. children aged from 4 to 8 years old, in good general health 2. children classified as class 3 or 4 based on frankel et al. classification. (26) 3. the children have at least one primary molar with class i carious lesion. 4. asymptomatic teeth (without spontaneous pain) exclusion criteria: 1. medically compromised patient 2. presence of pulp exposure, pain, mobility 3. presence of swelling, abscess or fistula near the tooth 4. not accessible carious lesion to hand instruments

Keywords: bioactive restorative material , art
prevalence of subclinical atrial fibrillation in heart failure patients and its relationship with hospital readmission

Conditions: Heart Failure; Atrial Fibrillation

Summary: multicentre, prospective cohort study in patients with a history of hf with preserved or reduced ejection fraction admitted to hospital with acutely decompensated hf. eligible and consenting patients will be enrolled at 3 hamilton, ontario area hospitals and receive 28-day ecg monitoring implemented at the time of hospital discharge. patients will be followed for a total of 1 year from hospital discharge.

in patients discharged from hospital after an admission for acute heart failure (hf) decompensation, subclinical atrial fibrillation (af) of 30 minutes or greater in duration is common (at least 15% of patients without prior af) and is associated with increased risk of re-hospitalization within 30-days. study objectives: 1. to evaluate the prevalence of subclinical af ≥30 minutes in duration in patients discharged from hospital following an admission for acute hf exacerbation and who have no known history of clinical af. 2. to examine the temporal association between subclinical af ≥30 minutes in duration and 30-day hospital readmission for hf.

Eligibility criteria:
inclusion criteria: 1. hospitalized with a most responsible diagnosis of acute decompensated heart failure. 2. clinical signs and symptoms of heart failure as per the boston criteria (i.e. score ≥8) exclusion criteria: 1. history of clinical atrial fibrillation 2. history of hypertrophic cardiomyopathy or congenital heart disease. 3. end stage renal disease or advanced renal dysfunction (e.g. estimated glomerular filtration rate, egfr \< 15 ml/min/1.73 m2) 4. cardiothoracic surgery in the past 30 days or imminently planned (does not include percutaneous procedures). 5. unable or unwilling to provide informed consent. 6. presence of a pacemaker or an icd with an atrial lead (which can already diagnose af).
hypoglycemia associated autonomic failure in type 1 dm, q4

Conditions: Type 1 Diabetes

Summary: epinephrine is one of the important hormones in the defense of hypoglycemia. we will test the hypothesis that antecedent hypoglycemia will blunt the metabolic, neuroendocrine and cardiovascular effects of subsequent epinephrine infusion in type 1 dm.

when a person had previously experienced bouts of low blood sugar, or hypoglycemia, his or her counterregulatory responses to hypoglycemia would be weakened. this is especially true and important for a person with type 1 diabetes, because it will cause him or her to be vulnerable to another bout of hypoglycemia, and cause hypoglycemia unawareness, which can lead to serious or even life-threatening consequences. epinephrine is one of the important hormones in the defense of hypoglycemia. we will test the hypothesis that antecedent hypoglycemia will blunt the metabolic, neuroendocrine and cardiovascular effects of subsequent epinephrine infusion in type 1 dm.

Eligibility criteria:
inclusion criteria: * 28 (14 males, 14 females) conventionally treated type 1 diabetic patients with ha1c \> 8.5% * 28 (14 males, 14 females) intensively treated type 1 diabetic patients with ha1c \< 7% * 28 (14 males, 14 females) non-diabetic controls * age 18-45 yr. * had diabetes for 2-15 years if diabetic subject * no clinical evidence of diabetic tissue complications, no cardiovascular disease * body mass index 21-27kg · m-2 * normal bedside autonomic function * normal results of routine blood test to screen for hepatic, renal, and hematological abnormalities * female volunteers of childbearing potential: negative hcg pregnancy test exclusion criteria: * prior history of poor health: any current or prior disease condition that alters carbohydrate metabolism and prior cardiac events and/or evidence for cardiac disease * hemoglobin of less than 12 g/dl * abnormal results following screening tests * pregnancy * subjects unable to give voluntary informed consent * subjects with a recent medical illness * subjects with known liver or kidney disease * subjects taking steroids * subjects taking beta blockers * subjects on anticoagulant drugs, anemic, or with known bleeding diseases

Keywords: epinephrine
neuromuscular re-eduaction, exercise and electric dry needling vs. neuromuscular re-education and exercise for stress urinary incontinence

Conditions: Stress Urinary Incontinence

Summary: the purpose of this research is to compare two different approaches for treating patients with stress urinary incontinence: neuromuscular re-education, impairment-based exercise and electric dry needling versus neuromuscular re-education and impairment-based exercise. physical therapists commonly use all of these techniques to treat stress urinary incontinence. this study is attempting to find out if one treatment strategy is more effective than the other.

patients with stress urinary incontinence will be randomized to receive 2 treatment sessions per week for up to 6 weeks (8-12 sessions total) of either: (1) neuromuscular re-education, impairment-based exercise and electric dry needling (2) neuromuscular re-education and impairment-based exercise

Eligibility criteria:
inclusion criteria: 1. aged 35 - 75 years 2. female 3. meet the diagnosis of stress urinary incontinence - urine leakage with increased abdominal pressure from laughing, sneezing, coughing, or other physical stressors on abdominal cavity and bladder exclusion criteria: 1. urge urinary incontinence or mixed urinary incontinence 2. greater than second degree prolapse 3. previous surgical intervention related to female anatomy 4. urinary tract infection 5. unable to participate in movement such as walking, stair climbing, or resistance training 6. taking medication that impacts bladder function 7. serious cardiovascular, cerebral disease, psychiatric disorder, cognitively impaired, injury of cauda equine, and/or myelopathy 8. pregnancy 9. sacral nerve stimulator implanted 10. cardiac pacemaker, metal allergy, or severe needle phobia