Kornimate/medical-research-clean huggingface dataset:
cortisol levels as a measure of accumulated physiological stress in icu patients undergoing mechanical ventilation

Conditions: Critical Illness

Summary: critical illness is a situation of severe and prolonged stress for patients with mechanical ventilation (mv). between 40-80% of these patients present the post-icu syndrome, a set of physical, cognitive, psychological alterations at hospital discharge. in more than a third of the icu survivors, these sequelae become chronic being observed months and even years after icu stay. the characteristics of the post-icu syndrome have been related to different risk factors associated with the critical illness and its management. however, the impact of accumulated physiological stress is still unknown. the physiological response to prolonged stress generates high levels of cortisol that have been related to the loss of muscle tissue, cognitive and psychological alterations in both clinical populations and healthy subjects. the concentration of cortisol in plasma is not a measure of adequate physiological stress due to the dysregulation of the hypothalamic-pituitary-adrenal (hpa) axis during critical illness. therefore, the objective of this study is to assess the levels of accumulated cortisol in human hair (chh) during the different stages of the critical illness and its recovery, as well as to explore its relationship with the functional and neuropsychological sequelae observed in the icu survivors.

a prospective pilot study has been proposed in 50 critical patients with\> 24 hours of mechanical ventilation. chh levels will be recorded at admission, 1 month and 1 year after icu discharge. in all survivors, the presence of delirium will be assessed during the icu stay and the functional, cognitive and psychological status will be assessed at short (1 month after icu discharge) and long term (1 year after icu discharge).

Eligibility criteria:
inclusion criteria: * critically ill patients with \>24hours of mechanical ventilation exclusion criteria: * previous neurological and/or psychiatric pathology * sensory alterations that prevent the application of the neurocognitive tests * cognitive impairment prior to icu admission (score \>57 in the short form of the informant questionnaire on cognitive. decline -short iqcode-) * sever alopecia * rejection of voluntary participation

Keywords: cortisol post-icu syndrome cognitive impairment anxiety and depressive symptoms mechanical ventilated patients
remineralization potential of ginger and rosemary herbals versus sodium fluoride in treatment of white spot lesions

Conditions: White Spot Lesions

Summary: to evaluate the effectiveness of ginger and rosemary herbals versus sodium fluoride in remineralization of incipient enamel caries.

group 1 (intervention) ginger and rosemary gel application: first the participant will be asked to brush his/her teeth thoroughly with 1450 ppm fluoride toothpaste (colgate total healthy clean toothpaste). then an application of a thin ribbon of this gel to the teeth using a brush. the medication will be left for at least 1 minute. the participant will be asked to spit out the medication after use and not to swallow it. also the participant will be asked not to rinse his/her mouth, eat, or drink for at least 30 minutes after use to get the best results. group 2 (control group). sodium fluoride varnish the fluoride varnish will be bifluorid 10 single use by voco (germany). it contains 5 % sodium fluoride (equal to 22,600 ppm fluoride). a thin coat will be applied on the tooth surface by using a brush. 10-20 s are sufficient for the varnish to be absorbed and then dry with air. participants will be informed that they should not brush their teeth for 12-24 hours after the application and not to eat, or drink for at least 30 minutes after use to get the best results.

Eligibility criteria:
inclusion criteria: * patient who has just completed a comprehensive orthodontic treatment. * presence of at least one wsl, diagnodent score (0-20). * age range between 13 and 35years. exclusion criteria: * patients with a compromised medical history. * severe or active periodontal disease * patients with developmental hypo-calcified lesions
contrast-induced nephropathy after revision of the prophylaxis threshold

Conditions: Contrast-induced Nephropathy

Summary: after administration of intravascular iodinated contrast media contrast-induced nephropathy (cin), also known as contrast-induced acute kidney injury (ciaki), may occur. cin/ci-aki is associated with increased risk of dialysis and mortality. no treatment exists for cin/ci-aki, therefore the focus lies on prevention. clinical practice guidelines for the prevention of cin/ci-aki exist and are implemented in most hospitals. generally, intravascular volume expansion with normal saline is recommended as prophylaxis. earlier this year the results of the amacing study (a maastricht contrast-induced nephropathy guideline study) were published in the lancet (nl47173.068.14/metc 14-2-006; clinical trials.gov nct02106234; http://www.thelancet.com/journals/lancet/article/piis0140-6736(17)30057-0/fulltext). these results show that for the greater part (\>90%) of patients considered to be at risk of cin/ci-aki by the guidelines, withholding prophylaxis is non-inferior to giving standard intravenous prophylactic hydration in the prevention of cin/ci-aki. furthermore, the standard prophylactic hydration confers some risk (5.5% complications of intravenous hydration were recorded in the amacing study). as a result the clinical protocol in the maastricht university medical centre (mumc+) has been adapted, and patients with an estimated glomerular filtration rate (egfr) \>29ml/min/1.73m2 no longer receive intravenous prophylactic hydration before or after procedures with intravascular iodinated contrast material administration. cinart is a one year prospective observational study with the aim to evaluate the consequences of the protocol change for 1. for incidences of cin/ci-aki, dialysis and mortality, 2. for clinical practice in terms of patient burden (complications of prophylaxis), hospital burden (extra hospitalisations for prophylaxis), and costs, as derived from the number of elective procedures carried out in patients formerly eligible for prophylaxis.


Eligibility criteria:
inclusion criteria: * referred for an elective procedure with intravascular iodinated contrast administration at maastricht university medical centre * egfr30-44ml/min/1.73m2 or egfr45-59ml/min/1.73m2 + dm or egfr45-59ml/min/1.73m2 + \>1 risk factor (\>age \>75 years, anaemia, cardiovascular disease, prescribed nsaid or diuretic medication) or multiple myeloma/lymphoplasmacytic lymphoma with small chain proteinuria. exclusion criteria: * egfr\<30ml/min/1.73m2 * dialysis/renal replacement therapy * emergency procedure * intensive care patient

Keywords: contrast-induced nephropathy contrast-induced acute kidney injury prophylaxis intravenous hydration
qualitative evaluation of pediatric obesity therapeutic education programs

Conditions: Pediatric Obesity

Summary: obesity concerns almost the entire planet and is considered in france as a major public health issue: 17% of children are overweight and 4% obese. because of this situation, the public authorities have set up programs in order to overcome obesity. accompanying the child and its family in a process of change through educational care program seems to be the most suitable. unfortunately, the abandonment rate of these programs is often high.

the main aim of this study is to explore, describe and understand the phenomenon of attrition in different pediatric obesity educational care program since 2017 by collecting their experience by describing and characterizing the reasons for attrition reported by the patients included.

Eligibility criteria:
inclusion criteria: * children who have started an educational care program between 2017 and 2022 at one of the four participating centers. * children whose parents or legal guardians have signed the program participation letter. * children who have participated in at least one group session and have stopped the educational care program early. * children whose parents have agreed to take part in the focus group for themselves and their child. * children over 12 years of age at the time of the focus group. exclusion criteria: * child who has completed the educational care program * parent/child pairs where at least 1 of the 2 refused to take part in the study

Keywords: pediatric obesity attrition educational care program
desvela. personal skills as determinants of morbidity, lifestyles, quality of life, use of services and mortality.

Conditions: General Population; Health Knowledge, Attitudes, Practice; Empowerment; Health Care Utilization; Life Style; Self Efficacy; Activation, Patient; Locus of Control; Quality of Life

Summary: quantitative study: the main objective is to analyze whether personal skills related to behaviours are independently associated with the incidence of morbidity. study with quantitative and qualitative methodology. multicenter project (10 teams) for the creation of a cohort of 3083 people aged 35 to 74 years of 9 autonomous communities (aacc). the personal variables that will be evaluated are: self-efficacy, activation, health literacy, resilience, locus of control and personality traits. socio-demographic covariates, social capital and community health assets will be recorded. as a secondary objective, it will be analyzed whether personal skills are independently associated with lower all cause mortality, better adoption of healthy lifestyles, higher quality of life and less utilization of health services in follow-up. a physical examination, a blood analytical and a cognitive evaluation will be carried out. the incidence of morbidity will be analyzed with a cox model for each of the six independent variables (objective 1); and mortality from all causes and from the other dependent variables (objective 2). the models will be adjusted by the indicated covariables. the possible heterogeneity between (aacc) will be estimated by introducing random effects into the model. qualitative study: to deepen in the opinions and experiences of the population on the relationship between personal skills with their perception of health, their lifestyles and their quality of life. the research will be carried out from a phenomenological perspective. the number of discussion groups needed to reach the saturation of speeches will be made. there will be an analysis of thematic content that will be triangulated between members of the research team. the meanings will be interpreted and an explanatory framework will be created with the contributions of each type of informant.


Eligibility criteria:
inclusion criteria: - population ascribed to primary health centres in spain. exclusion criteria: * illness at terminal phase. * institutionalization. * intellectual disability. * dementia. * idiomatic difficulties

Keywords: primary health care health promotion quality of life life style health literacy empowerment locus of control personality self efficacy
assessing the quality of life of patients with rosacea

Conditions: Rosacea

Summary: the study population consisted of 160 patients (123 women and 37 men) with rosacea, who agreed to participate in this study. patients were qualified for the study among people visiting the cosmetic studio in choroszcz in the period from june 2017 to november 2018, based on the diagnosis of a dermatologist and cosmetologist. the cosmetic intervention was performed using capillary repair serum (30ml). study participants completed self-reported questionnaire and standardized questionnaires.


Eligibility criteria:
inclusion criteria: * the inclusion criteria were: age ≥ 30 years, * diagnosis of rosacea according to the criteria of the national rosacea society expert committee (nrsec) from 2019, * tolerance to the ingredients of the preparation used in the cosmetic intervention, * lack of pregnancy and lactation, * completion of a survey, * signed informed consent exclusion criteria: * age \< 30 years, * patients with other facial skin diseases (e.g. acne, psoriasis, eczema), * intolerance to the ingredients of the preparation used in the cosmetic treatment, * patients with neuropsychiatric diseases, pregnancy, lactation, * patients who did not sign informed consent to participate in the study * did not complete the survey questionnaire.

Keywords: quality of life cosmetics procedures lifestyle dietary antioxidants
incidence of type 2 diabetes in the di@bet.es study

Conditions: Diabetes Mellitus, Type 2

Summary: our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from spain (di@bet.es study). the target was the spanish population. the sample consisted of 5072 people older than 18 years, in 100 clusters (health centres randomly selected from all over spain). the following variables were recorded: socio-demographic and clinical data, survey on habits (physical activity and frequency of selected food consumption) and a physical examination was made (weight, height, waist, hip, blood pressure). a fasting blood draw and an oral glucose tolerance test were performed. determinations of serum glucose were made. in the follow-up the same variables were collected and hba1c was determined. a total of 2408 subjects participated in the follow-up (7.5±0.6 years, 39.7% men). in total, 154 people developed diabetes (6.4% cumulative incidence in the 7.5 years of follow-up). the incidence of total diabetes adjusted for the structure of age and sex of the spanish population was 11.6 cases/1000 person-years (ic95%=11.1-12.1). the incidence of known diabetes was 3.7 cases/1000 person-years (ic95%=2.8-4.6) and the incidence of unknown diabetes was 7.9 cases/1000 person-years (ic95%=5.3-8.1). the main risk factors for developing diabetes were the presence of prediabetes in cross-sectional study, age, male sex, obesity, central obesity, increase in weight, and family history of diabetes. this work provides data about population-based incidence rates of diabetes and associated risk factors in a nation-wide cohort of spanish population.


Eligibility criteria:
inclusion criteria: * general population exclusion criteria: * diabetes in cross-sectional study * serious illness that prevents participation * pregnancy * surgery within the previous month * any other disabling situation that prevents participation
transcorneal electrical stimulation (tes) for the treatment of amblyopia

Conditions: Amblyopia

Summary: this is a prospective, randomized, parallel group sham-controlled blinded clinical trial to assess the feasibility and efficacy of transcorneal electrical stimulation (tes) in the improvement of visual function outcomes in adults with amblyopia. the trial will assess the treatment effect of tes to sham tes in the amblyopic eye of affected patients.

amblyopia is defined as a decrease in visual acuity in one eye, despite the correction of any refractive error with glasses and in the absence of any ophthalmoscopically visible lesion of the retina, especially of the macular region. amblyopia is associated with histologic and electrophysiologic abnormalities in the visual pathways. transcorneal electrical stimulation (tes), through neural stimulation, works by non-invasively stimulating the retina via passage of electrical current directly to the retina, bypassing the usual light activation pathway, resulting in the activation of the same areas of the brain as would be activated with a light stimulus alone. electrical stimulation with tes has shown potential in recent reports as an efficacious treatment modality to improve visual function. the success of electrical stimulation in neurodegenerative disorders provides a reasonable rationale and significant precedent to investigate its potential for use in disorders of the visual processing system, which functions via an integration of biochemical and electrical interactions transmitted from the retina.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years 2. diagnosis of amblyopia made by the principal investigators. 3. best corrected visual acuity in the amblyopic eye equal to or worse than 20/70 4. willing and able to give informed consent and to participate for the full duration of the study. 5. strabismus less than 10 prism diopters. exclusion criteria: 1. any other significant ophthalmologic disorder or condition with relevant effect upon visual function as evaluated by principal investigator. (eg. retinal degeneration, proliferative diabetic retinopathy, age related macular degeneration, optic nerve abnormality) 2. women who are pregnant or women with childbearing potential who are unwilling to use medically acceptable means of birth control for study duration. 3. presence of a pacemaker, any metal artifacts in head and trunk, any history of epileptic seizure or severe psychiatric disease (schizophrenia, etc.) 4. inability to detect phosphenes above 0.5ma at time of threshold detection.

Keywords: tes transcorneal electrical stimulation amblyopia
safety and efficacy of smart101 in adult patients with hematological malignancies after haploidentical hsct with post-transplant cyclophosphamide

Conditions: Hematological Malignancies

Summary: the purpose of this study is to evaluate the safety and the efficacy of smart101 (human t lymphoid progenitors (htlp)) injection to accelerate immune reconstitution after haploidentical hematopoietic stem cell transplantation (hsct) with post-transplant cyclophosphamide (pt-cy) in adult patients with hematological malignancies.


Eligibility criteria:
main inclusion criteria: * patients with aml, all or mds eligible for an allogeneic hsct with a haploidentical donor with post-transplant cyclophosphamide. * patients must be ≥ 18 years of age at the time of signing the icf. * patients must have a karnofsky index ≥ 70%. * patients must have a left ventricular ejection fraction of ≥40%. * patients must have an intact pulmonary function or diffusing capacity of the lungs for carbon monoxide (dlco) ≥ 45% of predicted. * patients must have adequate hepatic and renal functions, as assessed by standard laboratory criteria. main exclusion criteria: * patients who have received prior allogeneic stem cell transplantation. * patients who have received prior treatment with another cellular therapy within 4 weeks before the planned day of smart101 infusion. * patients who plan to receive, are concurrently receiving or have received any investigational agent within 4 weeks before the planned day of smart101 infusion.

Keywords: aml, all, msd
role of phosphorus and fgf 23 in patients with dent disease

Conditions: Dent Disease

Summary: patients with dent disease have suppressed levels of fgf 23 which contributes to hypercalciuria, kidney stones, nephrocalcinosis and renal failure. supplementation with phosphorus may reduce hypercalciuria.


Eligibility criteria:
inclusion criteria: patients will be recruited from those in the rksc dent registry 1. diagnostic criteria for dent disease observational arm include: 1. \<18 years old 2. lmwp (at least 5 times above the upper limit of normal) and at least 1 of the following criteria: 1. hypercalciuria, 2. kidney stones, 3. nephrocalcinosis, 4. hypophosphatemia, 5. renal phosphate leak, 6. aminoaciduria, 7. glucosuria without diabetes mellitus, 8. hematuria, 9. renal insufficiency, 10. family history with x-linked inheritance or 3. 1 of the above criteria (1-9) and confirmed genetic mutation of clcn5 or ocrl1. 2. diagnostic criteria for dent disease intervention arm include: 1. \>18 years old 2. lmwp (at least 5 times above the upper limit of normal) and at least 1 of the following criteria: 1. hypercalciuria, 2. kidney stones, 3. nephrocalcinosis, 4. hypophosphatemia, 5. renal phosphate leak, 6. aminoaciduria, 7. glucosuria without diabetes mellitus, 8. hematuria, 9. renal insufficiency, 10. family history with x-linked inheritance or 3. 1 of the above criteria (1-9) and confirmed genetic mutation of clcn5 or ocrl1. 3. idiopathic calcium nephrolithiasis with renal phosphate leak 1. male patients \> 18 years old 2. history of symptomatic calcium oxalate or calcium phosphate stone, hypercalciuria (\>250 mg/24 hrs), renal phosphate leak (tmp/gfr \<2.07 mg/dl) 4. idiopathic calcium nephrolithiasis without renal phosphate leak 1. male patients \> 18 years old 2. history of symptomatic calcium oxalate or calcium phosphate stone, hypercalciuria (\>250 mg/24 hrs), renal phosphate leak (tmp/gfr \<2.07 mg/dl) exclusion criteria: 1. exclusion for dent disease include: primary or secondary hyperparathyroidism, hyperthyroidism, chronic diarrhea states; intake of thiazide diuretics, glucocorticoids, or estrogens within one month of the study. 2. exclusion criteria for calcium stone formers include: primary or secondary hyperparathyroidism, hyperthyroidism, estimated gfr \<40 ml/mn/1.73m2, chronic diarrhea states; intake of thiazide diuretics, glucocorticoids, or estrogens within one month of the study. 3. exclusion criteria include history of symptomatic or asymptomatic kidney stone disease; primary or secondary hyperparathyroidism; estimated gfr \<40 ml/min/1.73m2, chronic diarrhea states; intake of thiazide diuretics, glucocorticoids, or estrogens within one month of the study.

Keywords: dent dents dent disease phosphorus supplements fgf 23
lateral closing wedge osteotomy for cubitus varus deformity in children

Conditions: Deformity; Bone

Summary: humeral osteotomy is the most effective method for evident cubitus varus correction in children. several osteotomy methods and fixation materials have been developed in the past. by applying the principles of deformity correction described by paley, the investigators describe a novel corrective technique for cubitus varus involving lateral osteotomy using kirschner wires.

supracondylar humerus fractures (shfs) account for approximately 10% of all pediatric fractures in children. poorly treated shfs can lead to the most common cubitus varus deformity especially in patients treated conservatively. the cosmetic aspect of this deformity is the main concern of patients, together with reduced remodeling ability. inevitably, surgery is the first choice for such patients. several osteotomy techniques and fixation materials have been developed in the last several decades. with the advent of three-dimensional printing techniques and computed tomography reconstruction methods, more accurate computing designs have been applied in the correction of cubitus varus. these techniques make the surgery more complex and require the performance of computed tomography (ct), resulting in high radiation exposure in children. paley described the principles of deformity correction that are widely used for the lower limbs. these principles represent an alternative with easy application without the need of ct, with less occurrence of prominence and good cosmetic outcome. according to the paley principles, all the vertex of the triangular osteotomy should site on the center of rotation of angulation (cora) line, by doing this, the gun-butt deformity was corrected perfectly. more importantly, they help to accurately correct the anatomic axis of the upper limb. according to our knowledge, this is the first study describes the lateral closing wedge osteotomy for correction cubitus varus deformity in children by applying paley's principles and fixation with k-wires. taken together, the investigators aimed at verifying the feasibility of paley's principles for deformity correction to treat cubitus varus in children.

Eligibility criteria:
inclusion criteria: * surgery performed over 6 months after the occurrence of shfs * difference in flexion angles of the affected and unaffected limbs of \>15 degrees * recovery of elbow function pre-ostomy exclusion criteria: * any other surgical approach used * consent not obtained from the patient's guardians * incomplete follow-up

Keywords: cubitus varus supracondylar humerus fracture osteotomy