Kornimate/medical-research-clean huggingface dataset:
granulocyte colony stimulating factor (g-csf) in acute liver failure and alcoholic hepatitis

Conditions: Liver Failure, Acute

Summary: granulocyte colony stimulating factor in acute liver failure and alcoholic hepatitis

in this study 4 groups have been taken. two groups of cases including alcoholic patients and acute liver failure which are given g-csf therapy and two groups of controls given standard therapy. primary end point is to see the mobilization of cd-34 hematopoietic cells and survival. secondary end point is to see the clinical and biochemical improvement in liver functions.

Eligibility criteria:
inclusion criteria: * patients with acute liver failure as defined by aasld.65 * patients with alcoholic hepatitis defined as follows: decades of heavy alcohol use (mean intake, approximately 100 g per day).the combination of an aspartate aminotransferase level that is elevated (but \<300 iu per milliliter) and a ratio of the aspartate aminotransferase level to the alanine aminotransferase level that is more than 2, a total serum bilirubin level of more than 5 mg per deciliter (86 μmol per liter), an elevated inr, and neutrophilia. exclusion criteria: • known hypersensitivity to filgrastim * creatinine \> 150 µmol/l * infection or hemorrhage within the last 10 days * documented hepatocellular carcinoma * hepatitis b,c or human immunodeficiency virus seropositivity and pregnancy

Keywords: liver failure, acute
resistance training in diabetic elder patients

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to investigate the effect of a 12-week progressive resistance training program on the skeletal muscle function, glycemic control, functional capacity, and quality of life in the elderly with type 2 diabetes mellitus.


Eligibility criteria:
inclusion criteria: * 65 years old or older * no clinical diagnosis of cardiovascular disease * patients with or without type 2 diabetes mellitus exclusion criteria: * glycated hemoglobin \> 10% * pulmonary disease * cancer * cognitive dysfunction * any neurological or musculoskeletal disease that will affect exercise performance

Keywords: diabetes mellitus resistance exercise elderly skeletal muscle dysfunction metabolomics
effects of mulligan technique with or without diclofenac phonophoresis on patellofemoral pain syndrome.

Conditions: Patellofemoral Pain Syndrome

Summary: the patellofemoral pain syndrome (pfps) is a common cause for "anterior knee pain" and mainly affects young women. the effectiveness of mulligan technique with or without diclofenac phonophoresis on pain, range of motion and functional disability of knee joint in patients with patellofemoral pain syndrome is known little. this study, ethically approved, focused on patients with anterior knee pain referred to the physical therapy department from lahore general hospital. after eligibility assessments and consent, participants were randomly assigned to group a (experimental) or group b (control). over four weeks, three sessions per week, routine physiotherapy and specific exercises will be administered, with group a receiving additional phonophoresis using ultrasound and diclofenac gel. outcome variables (numeric pain rating scale, koos-pf, universal goniometer) will be assessed by a blinded assessor at baseline and study completion.

background: the patellofemoral pain syndrome (pfps) is a common cause for "anterior knee pain" and mainly affects young women without any structural changes such as increased q-angle or significant pathological changes in articular cartilage. objective: to evaluate the effectiveness of mulligan technique with or without diclofenac phonopheresis on pain, range of motion and functional disability of knee joint in patients with patellofemoral pain syndrome. methodology: this study, ethically approved, focused on patients with anterior knee pain referred to the physical therapy department from lahore general hospital. after eligibility assessments and consent, participants were randomly assigned to group a (experimental) or group b (control). over four weeks, three sessions per week, routine physiotherapy and specific exercises were administered, with group a receiving additional phonophoresis using ultrasound and diclofenac gel. outcome variables (numeric pain rating scale, koos-pf, universal goniometer) were assessed by a blinded assessor at baseline and study completion.

Eligibility criteria:
inclusion criteria: * • patients of age range 20-45 years and both genders (rehman, 2021 #171) * unilateral anterior knee pain persisting for over two months, referred by orthopedic (rehman, 2021 #171) * pain scoring rate on numeric pain rating scale (nprs) \>3 during at least two activities (rehman, 2021 #171) * patients with positive clarke's test/ patellar grind test (rehman, 2021 #171) * pain while going up and down stairs, when sitting with knees flexed and with squatting, kneeling or returning from squat. (powers, 2017 #172) exclusion criteria: * • patients with other knee pathologies; meniscus tears, bursitis, patellar tendon injury, ligamentous injury * degenerative joint disorders; knee osteoarthritis, rheumatoid arthritis etc. * patellofemoral dislocation and / or frequent subluxation. * patients having undergone lower extremity surgery * those taking any pain medications

Keywords: patellofemoral pain syndrome, mulligan mobilization phonophoresis diclofenac
study in children with the diagnosis of congenital diaphragmatic hernia (cdh) and oesophageal atresia (ea)

Conditions: Diaphragmatic Hernia; Oesophageal Atresia

Summary: observational longitudinal study in children operated at birth on diaphragmatic hernia and/or oesophageal atresia : assessment of lung function parameters; assessment of quality of life and cognitive development; assessment of stress parenting and strategies of adaptation.

observational longitudinal study in children operated at birth on diaphragmatic hernia and/or oesophageal atresia : assessment of lung function parameters; assessment of quality of life and cognitive development; assessment of stress parenting and strategies of adaptation. tools: anamnestic-clinical questionnaire, spirometry, plethysmography, fractional exhaled nitric oxide (feno) assessment (oral and alveolar ), 6-minutes walk test (wt 6'), prick tests, quality of life in children questionnaire(kindl, quality of life), psychological test for cognitive development (raven matrices)

Eligibility criteria:
inclusion criteria: * children operated at birth on diaphragmatic hernia and/or oesophageal atresia * written informed consent, signed by parents exclusion criteria: * children that have had infections in the last 4 weeks * children with ongoing diseases * children that take drugs able to modify the lung function
analysis of growth factors in patients undergoing lucentis or avastin injections for diabetic macular edema and exudative macular degeneration

Conditions: Exudative Macular Degeneration; Diabetic Macular Edema

Summary: the purpose of this study is to measure biomarkers in the vitreous of patients undergoing lucentis or avastin treatment.


Eligibility criteria:
inclusion criteria: * male or female age 18 to 85 with diabetes and hemoglobin a1c \</= 10, or exudative macular degeneration. * diabetic macular edema with average retinal thickness central subfield \>/= 290um. exclusion criteria: * macular atrophy/fibrosis. * ocular anti-vegf treatment within 3 months. * treatment with topical or oral carbonic-anhydrase inhibitor within one month * laser photocoagulation within 3 months (diabetic cohort)
acute effect of animal and vegetable protein rich meals with comparable dietary fibers content on appetite sensation and energy intake

Conditions: Obesity

Summary: background: * new nordic diet guidelines advocate a reduction in consumption of protein from animal sources such as beef and pork, due to environmental concerns. * instead, intake of protein from vegetable sources such as legumes and pulses should be increased. * a previous study showed that a meal enriched with vegetable protein increased the subjective sensation of satiety and decreased hunger and ad libitum energy intake (ei) compared to animal protein. * this study did, however, not document that vegetable protein per se is more satiating than animal protein as the vegetable meal had higher fiber content. fiber is a likely confounder. * the protein from egg is sparingly investigated in relation to appetite. few studies have found that eggs have a high satiety index but further investigation is needed. objective: - to examine if vegetable protein (beans and peas) can suppress subjective appetite (vas and ad libitum energy intake) compared to isocaloric meals enriched with either red meat or egg with similar distribution of macronutrients and content of dietary fibers. design: single-blind randomized 4-way crossover meal study subjects: 33 young healthy men (age: 18-50 years; bmi: 19-30 kg/m2). expected completers: n=30. end points: 1. subjective appetite (vas) (every 30 min for 3 hours) 2. ad libitum ei (3 hours after lunch test meal)


Eligibility criteria:
inclusion criteria: * healthy * bmi: 18.5-30.0 kg/m2 * weight stable (within +/- 3 kg) two months prior to study inclusion, * non-smoking * nonathletic (\< 10 h hard physical activity) exclusion criteria: * bmi \> 30 kg/m2 * change in smoking status * daily or frequent use of medication that can affect appetite * suffering from metabolic diseases * suffering from psychiatric diseases * suffering from any other clinical condition, which would make the subject unfit to participate in the study * alcohol and drug abuse * food allergies or relevance for the test meals

Keywords: protein sources appetite dietary fibers meat egg legumes
study of coagulation factor viia variant marzeptacog alfa (activated) in adult subjects with hemophilia a and b

Conditions: Hemophilia A With Inhibitor; Hemophilia B With Inhibitor

Summary: phase 2, multi-center, open-label study designed to evaluate the pk, bioavailability, pd, efficacy and safety of a daily subcutaneous \[sc\] treatment regimen with marzaa for bleeding prophylaxis in 12 adult subjects with hemophilia a or b with an inhibitor and history of frequent spontaneous bleeding episodes.

multi-center, open-label phase 2 study to evaluate the pk, bioavailability, pd, efficacy and safety of a daily sc treatment regimen with marzaa for bleeding prophylaxis in adult subjects with hemophilia a or b with an inhibitor. the study will enroll and dose, both intravenously and subcutaneously, a total of 12 adult male subjects with severe congenital hemophilia a or b with an inhibitor, and history of frequent bleeding episodes during the 6 months prior to enrollment, as per the individual's bleeding and treatment records. once a subject is enrolled into the trial, the study will be conducted in three parts (occurring consecutively): part 1a (24 hours): single iv administration of marzaa; part 1b (48 hours): single sc administration of marzaa; part 2: daily sc administration. dose escalation in part 2 will occur if breakthrough bleeding occurs. subjects are treated for 50 days at the final dose level required.

Eligibility criteria:
inclusion criteria: * severe congenital hemophilia a or b with an inhibitor. * history of frequent spontaneous bleeding episodes. * male, age 18 or older. * affirmation of informed consent with signature confirmation before any trial-related activities. exclusion criteria: * receiving prophylaxis treatment. * previous participation in a clinical trial evaluating a modified rfviia agent. * known positive antibody to fvii or fviia detected by central laboratory at screening. * have a coagulation disorder other than hemophilia a or b. * significant contraindication to participation.
cardiaq-edwards™ transcatheter mitral valve replacement (tmvr) study

Conditions: Mitral Valve Regurgitation

Summary: clinical study to evaluate the safety and performance of the cardiaq-edwards™ transcatheter mitral valve

the study is a multi-center, prospective, single-arm, and non-randomized study designed to evaluate the safety and performance of the cardiaq-edwards™ transcatheter mitral valve with transapical and transseptal delivery systems in patients with degenerative or functional/ischemic mitral regurgitation.

Eligibility criteria:
inclusion criteria: * nyha ≥ ii * moderate/severe or severe mitral regurgitation * prohibitive risk for open-heart surgery * meets anatomical criteria exclusion criteria: * unsuitable anatomy * need for emergent or urgent surgery * prior mechanical aortic valve replacement * any prior surgical or transcatheter repair (excluding balloon valvuloplasty) or replacement of the mitral valve * preexisting device in the left ventricular apex * clinically significant, untreated coronary artery disease * limited life expectancy (\< 12 months) * active infection

Keywords: mitral regurgitation insufficiency degenerative functional primary secondary organic transcatheter tmvr tmvi heart valve mitral valve transapical transfemoral transeptal severe
covid-19 risk factors and pattern between healthcare workers

Conditions: Covid-19

Summary: assessment of the pattern and risk factors of covid-19 between infected healthcare workers at assiut university hospitals

covid-19 is a respiratory infectious disease caused by a novel coronavirus, sars-cov-2. the first batch of covid-19 patients were found in december 2019 (1). the disease is mainly transmitted through respiratory droplets and close contact, and all people are susceptible to it (2). sars-cov-2 is highly contagious (3), and has quickly spread to most countries and regions of the world. covid-19 has become a global pandemic and has received great attention from all over the world (4, 5). till april 7, 2020, 1,214,466 confirmed cases of covid-19 have been found in 211 countries and regions, causing 67,767 deaths (6). the main clinical manifestations of covid-19 are cough, fever, malaise, chest distress and tachypnia and complications such acute respiratory distress syndrome. healthcare workers (hcws) are on front line of treating patients infected with covid-19. however, data related to infection rate among hcws are limited. early available evidence suggested that hcws are being increasingly infected with the novel infection ranging from 15% to 18% and in some cases up to 20% of the infected population. major risk factors of infection among hcws include lack of understanding of the disease, inadequate use and availability personal protective equipment (ppe), uncertain diagnostic criteria, unavailability of diagnostic tests and psychological stress. therefore the protection of hcws by authorities should be prioritized through education and training, the readiness of staff, incentives, availability of ppes, and psychological support. in this time of covid-19 pandemic, big problem in hospitals that are flooded with infected symptomatic and asymptomatic patients. a critical aspect is the protection of the hcws who are at risk, including individuals more than 50 years old those with presence of a systemic disease, smokers and disabled individuals. these hcws should be identified and not assigned duties inwards and premises managing covid 19 patients

Eligibility criteria:
inclusion criteria: - health care workers in assiut university hospitals ( ≥ 18 years old) who were infected with covid-19 and were diagnosed based on either pcr testing or based on radiological diagnosis. those who were not in contact with household covid-19 patients within 14 days before getting infected. those who were adherent to social isolation apart from their work b. exclusion criteria : patients with covid-19 who are not hcws in assiut university hospital. those who were in contact with household infected patients within 14 days before getting infected.
comparison of using collagen membrane and a-prf using vista technique in gingival recession treatment

Conditions: Gingival Recession

Summary: to assess the efficacy of minimally invasive vestibular incision subperiosteal tunnel access (vista) with collagen membrane and advanced platelet-rich fibrin (a-prf) in the treatment of multiple buccal gingival recession type 1(rt1) cairo classification.


Eligibility criteria:
inclusion criteria: * (18-50) years old with at least 2 sites with gingival recession type (rt1) cairo classification (gr with no interdental attachment loss). the interdental cej is not detectable clinically on the labial surfaces of the teeth. * recession in the maxillary anterior region ≥1 mm of attached gingiva, pocket depth (pd) of \<3 mm, recession depth (rd) ≥2 mm, and gingival index (gi) score ≤1. * systemically healthy, willing individuals with good oral hygiene and without contraindications for surgical interventions exclusion criteria: * the presence of severe systematic diseases or immunodeficiency and contraindicated with surgical interventions. * allergies to medicaments used in the treatment process. * patients with removable or fixed dentures. * patients with cervical abrasion, direct and indirect restorations involving the cervical areas of the maxillary anterior. * participants with smoking, tobacco chewing, and alcohol consumption. * the presence of high frenal attachment and participants who had previously undergone any periodontal surgical procedure or regenerative therapy in the past 1 year at the same site of the planned treatment.
the gratitude gallery - a positive psychology intervention

Conditions: Depression; Anxiety

Summary: this study will assess the feasibility and acceptability of a positive psychology intervention, the gratitude gallery, for increasing gratitude in adults. the study hypothesizes that participants will find the activity feasible and acceptable and complete the intervention as directed. the project also hypothesizes that those that complete the intervention will show an increase in self-reported gratitude, as well as a decrease in symptoms of anxiety and depression.


Eligibility criteria:
inclusion criteria: * able to read/understand english and give consent * owns a smart phone capable of taking pictures * willing and able to comply with all aspects of study procedures * phq-9 score greater or equal to 5 but less or equal to 14 with no suicidal ideation * generalized anxiety disorder (gad-7) score greater or equal to 0 but less or equal to 9 * no plan to initiate a new program that could increase positive affect during the study period (e.g., psychotherapy, new exercise regimen, meditation classes) * if on medication then stable (at least 3 months) on dose or not on medication exclusion criteria: * having a psychotic disorder active suicidality or severe depressive or anxiety symptoms * other factors that at the discretion of the investigators that would adversely affect study participation

Keywords: photos photography gratitude
timing of initiation of lmwh administration in pregnant women with aps

Conditions: Recurrent Miscarriage; Antiphospholipid Syndrome

Summary: evaluation of the effect of altering the timing of initiation of low molecular weight heparin (lmwh) administration on the pregnancy outcomes in women with antiphospholipid syndrome (aps)

women will be randomly divided into two groups; one will start enoxaparin therapy once positive pregnancy test is established and the other will start enoxaparin therapy after sonographic confirmation of fetal cardiac pulsation. in all women, enoxaparin will be given in a dose of 40 mg/day subcutaneously and the therapy will continue until termination of pregnancy

Eligibility criteria:
inclusion criteria: * pregnant women with aps diagnosed according to the revised classification criteria for aps in 2006 in sydney, australia * early pregnancy body weight is 50-90 kg exclusion criteria: * women with systemic lupus erythematosus (sle) * women with active thromboembolic disorders * women with history of previous thromboembolic disorders

Keywords: antiphospholipid syndrome aps lmwh
management of glycemia following a pizza meal

Conditions: Diabetes Mellitus, Type 1

Summary: glycemia following pizza consumption is typically managed with a dual wave insulin bolus. this study evaluated the effect of a simple bolus on glycemia following consumption of traditionally prepared pizzas with long (22 hours) or short (8 hours) dough fermentation periods.

all participants received pizza prepared in one of two ways, as described below, on two separate days. on the first day, they were given a pizza prepared with dough fermented for 8 hours (pizza a), and on the second study day they received a pizza prepared with dough fermented for 24 hours (pizza b). participants and their parents were blinded to the type of pizza served on each day. both meals were served at 7.00 pm at the pizzeria where the pizza had been prepared, and consumed within 30 minutes. children and adolescents aged between 4 and 18 years with type 1 diabetes were eligible for inclusion in the study if they had received sip therapy (minimed™ 640g, medtronic, tolochenaz, switzerland) for at least 3 months one pizza of each type was prepared for chemical analysis

Eligibility criteria:
inclusion criteria: * type 1 diabetes if they had received sensor integrated pump (sip) therapy for at least 3 months exclusion criteria: * patients with hba1c \>8.5% (69 mmol/mol), celiac disease, other food allergies or concurrent illness

Keywords: continuous subcutaneous insulin infusion diet postprandial glucose postprandial hypoglycemia postprandial hyperglycemia
blood biomarkers in paediatric mtbi

Conditions: Mild Traumatic Brain Injury

Summary: the goal of this observational study is to identify blood biomarkers that could help in the management of paediatric patients with mild tbi. the main questions it aims to answer are: 1. how can blood biomarkers reduce unnecessary ct scan and reduce the length of stay at the emergency department? 2. how can blood biomarker predict post-concussion symptoms? participants will have a blood sample taken when they are admitted at emergency department and will receive a questionnaire describing their symptoms 14 days and 3 months after their trauma.

mild traumatic brain injury (mtbi) in children is a very frequent reason for presentation at the paediatric emergency department. in most cases, the trauma will not lead to intracranial lesions. the first objective for clinicians is therefore to detect all children in need of neurosurgical intervention after mtbi. although computerized tomography (ct) is currently the modality of choice for acute intracranial haemorrhage identification, care should be taken to avoid unnecessary exposure to ionizing radiation in the developing brain. monitoring the occurrence of bleeding usually involves an observation period which generally extends from six to twenty-four hours. this time is stressful for the child and parents as well as time and cost consuming for the hospital. in addition to the acute conditions, it has been described that post-concussion symptoms can occur in the weeks or months following the trauma, and neuropsychological follow-up of these children could help prevent or reduce the symptoms. the aim of our study is to find biomarkers that can identify children with clinically important intracranial injury and/or children that will eventually suffer from a post-concussion syndrome.

Eligibility criteria:
inclusion criteria: * mtbi within 24 hours exclusion criteria: * refusal of child or parents * evidence of intoxication with alcohol or other substances * history of tbi ( less than one month) * epilepsy, encephalitis, meningitis, melanoma