Kornimate/medical-research-clean huggingface dataset:
couple-based treatment for alcohol use disorders and post-traumatic stress disorder

Conditions: Alcohol-related Disorders; Post-traumatic Stress Disorder

Summary: the purpose of this study is to develop and test a couple-based treatment for veterans with an alcohol use disorder and post-traumatic stress disorder.


Eligibility criteria:
inclusion criteria: * veteran must meet diagnostic and statistical manual of mental disorders (dsm-iv; american psychiatric association, 1994) criteria for current (past 12 months) alcohol abuse or dependence and alcohol must be the veteran's primary substance of abuse as determined by a clinical algorithm (fals-stewart, stappenbeck et al, 2004); * veteran must meet dsm-iv criteria for current (past month) ptsd; * veteran consumed alcohol in the past 90 days; * couple must be married to or living with their current partner for at least 1 year; * veteran agrees to a goal of abstinence from drugs at least for the duration of the 15-week study-based treatment; * veteran agrees to the goal of abstaining from alcohol or consuming alcohol within low risk drinking guidelines during the duration of the 15-week study-based counseling; * veteran agrees to forego other treatment for alcohol-related disorders except for self help meetings (e.g., aa) or treatment required for a clinical emergency or clinical deterioration for the duration of the 15-week study based treatment; * veteran agrees to forgo other ptsd treatment except for treatment required for a clinical emergency or clinical deterioration for the duration of the 15-week study based treatment; * couple agrees to forgo other couple-based counseling for the duration of the 15-week study based treatment except for treatment required for a clinical emergency or clinical deterioration; * partner does not meet dsm-iv criteria for current (past 12 month) substance use disorder (other than nicotine) * partner does not meet dsm-iv criteria for current (past month) ptsd. exclusion criteria: * veteran has dependence on alcohol or other drugs that requires inpatient treatment or medical detoxification (as indicated by daily heavy use or use to prevent or deal with withdrawal symptoms) - after completing detoxification, veteran may be eligible for the study; * veteran or partner are at immediate risk for suicide or homicide (current plan or intent); * veteran or partner exhibit a history of suicide or homicide attempt in the past year; * veteran is participating in a methadone maintenance or suboxone maintenance program and is seeking treatment for adjunctive outpatient services; * veteran or partner meets dsm-iv criteria for a current organic mental disorder, schizophrenia, delusional (paranoid) disorder, or any of the other psychotic disorders.

Keywords: post-traumatic stress disorder alcohol-related disorders substance use disorders couple therapy
web clinical assessment of intrasaccular aneurysm therapy

Conditions: Intracranial Aneurysm

Summary: the objective of this clinical study is to evaluate clinical utility of the web aneurysm embolization system used to embolize intracranial aneurysms

the following parameters will be evaluated as part of this study: * aneurysm morphology * aneurysm size * for ruptured aneurysms: hunt and hess classification of subarachnoid hemorrhage (sah) * size of the embolization device(s) used in the procedure * intra-procedural assessment of aneurysm occlusion and flow stasis * degree of aneurysm occlusion post-procedure (percentage occlusion, raymond scale and other scores as appropriate) * aneurysm occlusion durability * recanalization rate * device-related changes in modified rankin scale from baseline * complications/adverse events * rebleed/new bleed

Eligibility criteria:
inclusion criteria: * must be at least 18 years of age * must sign and date an irb/ec-approved written informed consent prior to initiation of any study procedures exclusion criteria: * must not have clinical or angiographic evidence of vasospasm * must not have lesion with characteristics unsuitable for endovascular treatment * must not have neurologic or psychiatric conditions, which preclude ability to comply with all aspects of the screening, evaluation, treatment, and the post-procedure follow-up schedule * must not be concurrently involved in another investigational or post-market study * must not have received any investigational device for treatment of the target intracranial aneurysm prior to entry into this trial
surgical management of low grade glioma

Conditions: Low Grade Glioma of Brain

Summary: to assess the morbidity and mortality in low grade glioma patients following surgical management.

lower-grade gliomas histological diagnosis has had a long history, each iteration of disease classification suffered from continued variability, with detrimental consequences on prognostic precision and treatment decision making. in the who 2021 classification, there are three primary categories of adult-type diffuse gliomas: isocitrate dehydrogenase (idh)-mutant, 1p/19q codeleted oligodendroglioma; idh-mutant, non-codeleted astrocytoma; and idh-wildtype glioblastoma. diffuse low-grade glioma is classified as who grade 1 and 2 astrocytoma with idh mutation or oligodendroglioma with idh mutation and 1p/19q codeletion. the presence of the idh1 mutation has become a defining factor for adult diffuse low-grade glioma. roughly 70% of grade 2-3 gliomas harbor mutations in either idh1 or its mitochondrial counterpart idh2. although lower-grade gliomas may present in various ways, the most common manifestation is seizures, and the development of seizures during the course of the disease may herald tumor progression. among grade ii tumors, the incidence of epilepsy is higher with idh mutation. anaplastic gliomas are somewhat less likely to manifest with seizures (57%) and are more likely than grade ii gliomas to produce mental status, vision, and motor deficits.

Eligibility criteria:
inclusion criteria: * patients diagnosed radiologically with low grade glioma exclusion criteria: * patients not fit for surgery
chronic obstructive pulmonary disease patient preferences survey

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the purpose of this study is to distribute a questionnaire created for individuals living with chronic obstructive pulmonary disease (copd) to assess their activities, participation, and healthcare and copd-related research priorities. the data collected will be compared across diagnosed copd stages and disease severity to determine the extent to which adults with copd participate in the listed activities and identify their primary research and healthcare related priorities. the questionnaire was originally developed based on past research then verified by a panel of copd and participation experts; as well as, individuals living with copd in the form of focus groups. the questionnaire will now be administered to 200 individuals living copd (50 in each gold stage) at three sites across montreal where clinical data for each participant will be available. this phase will help establish the reliability of the questionnaire.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of copd * english or french speaking * patient at one of the three participating sites with medical chart exclusion criteria: * no diagnosis of copd by a healthcare professional * unable to communicate in english or french * unable to provide informed consent * no medical chart information at one of the three participating sites

Keywords: survey priorities activities participation
comparison of the effectiveness of the ultrasound guided injections in patients with shoulder impingement syndrome

Conditions: Shoulder Impingement; Ultrasound Guided Injection

Summary: shoulder pain, which is the third most common cause of musculoskeletal pain, has different etiologies. muscle, bone structures and connective tissue pathologies can cause shoulder pain. impingement syndrome (is), which can cover many terms such as rotator cuff disorders, tendinitis and tears, is one of the most common pathologies of shoulder pain.

the hypothesis of this study was that injection types including acj would increase treatment efficacy.therefore, this study investigated the six-month follow-up results of patients undergoing sa injection and ssnb and those receiving sa and acj injection.

Eligibility criteria:
inclusion criteria: * patients aged 18-65, * who were suffering from shoulder pain for more than three months and * who were diagnosed with is. * all patients included in the study were diagnosed with is using shoulder magnetic resonance imaging. exclusion criteria: * the presence of cervical radiculopathy; * undergoing shoulder operation before; * the presence of central nervous system or * the presence of rheumatological disease, and polyneuropathy; * receiving physical therapy in the shoulder area with a diagnosis of is within the last six months; and * receiving any injection therapy in the past.
benefit of virtual reality headset use on apathy in older adults with major neurocognitive disorders

Conditions: Apathy in Dementia; Aged; Virtual Reality; Neurocognitive Disorders

Summary: the goal of this clinical trial is to verify that virtual reality is tolerably compatible with apathetic pathologies in patients and residents with major neurocognitive disorders. the main questions it aims to answer are: * does virtual reality have an impact on symptoms of apathy in the elderly? * is virtual reality well tolerated by the elderly? participants will benefit from a 3-session virtual reality headset program with a healthcare professional. they will have one session per week for 3 weeks. they will be observed by another professional, who will complete observation grids on apathy, engagement in activity and tolerance of the virtual reality headset. there is not a comparison group: researchers will compare the scores before and after the intervention: the participant will be his own control.

this study is a multicenter interventional exploratory study in two nursing homes and a geriatric long-term care service. thirty patients will be included. they will be recruited from residents of the long-term care departments of two hospitals, and 4 nursing homes. a pre- and post-intervention comparison will be made by assessing apathy using the apathy inventory and the neuropsychiatric inventory in the care team version. a comparison of participants' engagement will be carried out through ecological observation of the interventions. this will be objectivized by the caregiver interaction behavior scale (ecpai) before the immersion program, and during the first and third virtual reality sessions. an ecpai scale taken during a conventional animation prior to the program will establish a baseline state for the participant. the main goal is to verify that virtual reality is tolerably compatible with apathetic pathologies in patients and residents with major neurocognitive disorders.

Eligibility criteria:
inclusion criteria: * persons over 65 years of age * persons living in nursing homes or hospitalized in long-term care * persons with correct vision or vision corrected by glasses * people with no hearing problems, or with hearing loss corrected by a hearing aid * person with a major neurocognitive disorder * person with a mini mental state examination (mmse) cognitive score \<26 * individuals with documented apathy exclusion criteria: * person with a history of epilepsy * persons wearing a pacemaker * person with open wounds of the face or skull * disabling headache or neck pain * person at the immediate end of life or in active palliative care * person with a contagious disease * people who are bedridden or unable to get into a wheelchair * persons with severe neurological impairment * person with severe behavioral disorders endangering self or staff * persons unable to give oral consent
continuous vs intermittent non invasive blood pressure monitoring in preventing post operative organ failure

Conditions: Blood Pressure Determination; Hemodynamic Monitoring; Postoperative Complications

Summary: continuous non-invasive arterial pressure monitoring has the potential to decrease the duration of intraoperative hypotension and hypertension compared to conventional intermittent blood pressure monitoring. chen et al. demonstrated using continuous non-invasive arterial pressure devices for every hour of surgery it is possible to identify an average of 14 minutes of potentially treatable hypotensive and hypertensive time(12). whether the ability to detect more hypotension events by continuous non-invasive arterial pressure monitoring use can improve patient outcomes, is still an open research question


Eligibility criteria:
inclusion criteria: * all adult (age ≥18 years) patients scheduled for elective non-cardiac surgery in participating centers * surgical case planned with non invasive blood pressure monitoring according to local clinical practice or policies. exclusion criteria: * missing of preoperative serum creatinine during 30 days prior surgery * preoperative dialysis * chronic kidney disease (egfr \< 60ml/min cockcroft-gault equation) * surgical procedure lasting less than 60 min * planned use of permissive hypotension * urological procedures (including nephrectomy and renal transplantation) * refusal to give informed consent

Keywords: volume clamp continuous non invasive blood pressure monitoring
pain control with pre-operative cryoneurolysis following tka

Conditions: Osteo Arthritis Knee

Summary: the purpose of this study is to assess the potential benefit of preoperative cryoneurolysis in postoperative pain management of total knee arthroplasty patients over current pain management protocol.

cryoneurolysis, is a novel technique that can yield temporary blockade of superficial sensory nerves, generating immediate and meaningful relief of pain.the technique generates an axonotmesis of the targeted peripheral nerves by percutaneously applying low temperatures (-100 °c to -20 °c). wallerian degeneration is produced whereby the axons and the myelin sheath are damaged but the endoneurium, perineurium and epineurium remain intact. therefore, permanent damage to the nerve is avoided as it retains its regenerative properties. with regards to the knee, the infrapatellar branch of the saphenous nerve (ipbsn), a sensory branch serving both the inferior and anterior portion of the knee capsule and the antero-medial skin of the knee is the prime target for the procedure. your participation in this study requires that you allow the radiology department of texas orthopedic hospital to administer cryoneurolysis using the iovera device with the functional smart tip approximately 1 week prior to total knee arthroplasty surgery. a highly localized cold zone is created via the joule-thompson effect as nitrous oxide enters the needles. nothing is injected into the body and the nitrous oxide gas is vented safely out of the handpiece. cryoneurolysis is administered following local anesthesia.

Eligibility criteria:
inclusion criteria: * any patient scheduled for primary total knee arthroplasty(tka) exclusion criteria: * bilateral tka (patients routinely receive spinal anesthesia) * minors * patients reporting a history of raynaud's disease * patients with an open and/or infected wound on surgical knee * patients who are taking opioids during the pre-operative period due to knee pain * patients who cannot return for the cryoneurolysis treatment 7 days prior to surgery or post-operative clinical visits * patients whose insurance would deny payment for the cryoneurolysis treatment * pregnant patients * patients unable to speak and read english

Keywords: knee joint replacement total knee cryoneurolysis iovera tka pain
safety and immunogenicity of mf59c.1 adjuvanted trivalent subunit influenza vaccine in elderly subjects

Conditions: Influenza

Summary: the present phase iii study aims to evaluate the safety and immunogenicity of mf59-adjuvanted subunit seasonal influenza vaccine and to evaluate the consistency in the manufacturing process of three consecutive lots of mf59-adjuvanted subunit seasonal influenza vaccine with respect to immunogenicity in subjects aged 65 years and older. the active comparator non-adjuvanted seasonal influenza vaccine is approved for use in this age group in the united states and will be used to provide a comparative assessment for immunogenicity and safety.


Eligibility criteria:
inclusion criteria: males and females subjects aged ≥65 years at day of vaccination who are willing and able to comply to study procedures. exclusion criteria: 1. individuals with behavioral or cognitive impairment or a psychiatric condition or with a history of any illness that,in the opinion of the investigator, would have interfered with the subject's ability to participate in the study. 2. individuals who were not able to comprehend and/or follow all required study procedures for the whole period of the study. 3. known or suspected impairment/alteration of immune function. 4. individuals with a known bleeding diathesis. 5. history of guillain-barré syndrome. 6. individuals with history of allergy to vaccine components and/or a history of any anaphylaxis, serious vaccine reactions or hypersensitivity to influenza viral proteins, egg proteins (including ovalbumin), polymyxin, neomycin, betapropiolactone, thimerosal/ sodium ethylmercurothiosalicylate/ mercury and nonylphenolethoxylate/ nonoxynol-9 (spermicide). 7. receipt of another investigational agent within 30 days prior to enrollment in the study or before completion of the safety follow-up period in another study. 8. individuals who had received any other vaccines within 2 weeks for inactivated vaccines or 4 weeks for live vaccines prior to enrollment in this study or who had planned to receive any vaccine within 3 weeks from the study vaccine. 9. individuals who had received vaccination against seasonal influenza in the previous 6 months. 10. individuals with oral temperature ≥38.0°c (≥100.4°f) on day of study vaccination. 11. individuals with history of substance or alcohol abuse within the past 2 years. 12. individuals providing consent who did not consent to the retention of their serum samples after study completion. 13. elective surgery or hospitalization planned to occur during the treatment phase or during the follow-up phase that, according to the opinion of the investigator, might have poses additional risk to the subject. 14. subjects from whom blood could not be drawn at visit 1.

Keywords: elderly influenza immunogenicity safety adjuvant adjuvanted adjuvants vaccines
hiv prevention with adolescents: neurocognitive deficits and treatment response

Conditions: Risk Reduction Behavior; Sexual Behavior; Health Behavior; Drinking Behavior; Adolescent Behavior

Summary: this research is examining how genetic and brain factors play a role in adolescents' health risk behavior as well as studying behaviors that young people engage in that may place them at risk for contracting a sexually transmitted disease like hiv/aids, and what kind of educational program works best to reduce these risky behaviors.

a baseline assessment is conducted, including a computer questionnaire assessing personality characteristics, attitudes toward and experiences with sex, alcohol, drugs, and cigarettes, among other things. the participant also meets with a therapist to conduct a brief motivational interview at this time. a "time-line follow-back" is conducted; this notes incidences of sexual intercourse, alcohol use, marijuana use, and cigarette use in a 30-day period. an fmri is conducted, and a saliva sample is gathered. during the second session of the study, participants are randomly assigned to either a sex and alcohol risk reduction intervention, or a sex risk reduction intervention. after the intervention, participants are contacted at 3 month intervals (3 months later, 6 months later, 9 months later, and 12 months later) to meet. at these "follow-up" meetings, another time-line follow-back is conducted, along with another computer questionnaire (again assessing attitudes toward and experiences with sex, alcohol, drugs, and cigarettes).

Eligibility criteria:
inclusion criteria: * adolescents age 14-18 * involved in juvenile justice system or enrolled in a private school exclusion criteria: * currently taking anti-psychotics * involved in similar intervention-based study (2 similar studies being conducted simultaneously by this lab)
building equitable linkages with interprofessional education valuing everyone

Conditions: Pregnancy Related; Postpartum; Pain

Summary: this is a step-wedge design implementation protocol of an interprofessional education curriculum intervention that is delivered through virtual reality and designed to reduce disparities and improve patient experiences in receiving maternal healthcare.


Eligibility criteria:
inclusion criteria: healthcare team participants * employed as one of the following roles: maternity care provider, nurse, lactation consultant or doula. * primary inpatient clinical assignment is maternity care. * if per diem: employed for a minimum of 4 shifts/month at a participating site. birthing parent data extraction participants • had a live birth at a participating site from the start of the study through the last data retrieval timepoint. birthing parent interview participants * had a live birth at a participating site from the start of the study through the last data retrieval timepoint. * black race or limited english proficiency with preferred language of spanish. * age ≥ 18. exclusion criteria: healthcare team participants • none birthing parent data extraction participants • baby with birth gestational age \< 24 weeks. birthing parent interview participants * baby with birth gestational age \< 24 weeks. * baby is no longer alive at time of data retrieval (regardless of gestational age). * currently incarcerated. * previously completed a birthing parent interview for the believe study. * previously enrolled as a healthcare team participant.

Keywords: maternity hospitals
vitamin b12 for carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: carpal tunnel syndrome (cts) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel. rather than other progressive disease, cts is characterized by remission and recurrence. the hydrodissection could decrease the entrapment of nerve to restore blood supply. in addition, the vitamin b12 was considered to be beneficial for peripheral neuropathy and pain relief. the investigators design a randomized, double-blind, controlled trail to assess the effect after ultrasound-guided hydrodissection with vitamin b12 in patients with cts.

after obtaining written informed consent, patients with mild to moderate cts will been randomized into intervention and control group. participants in intervention group received one-dose ultrasound-guided hydrodissection with 3cc vitamin b12 and control side received one-dose ultrasound-guided injection 3cc normal saline. no additional treatment after injection through the study period. the primary outcome is boston carpal tunnel syndrome questionnaire (bctq) and secondary outcomes include visual analog scale (vas), cross-sectional area (csa) of the median nerve, sensory nerve conduction velocity of the median nerve. the evaluation was performed pretreatment as well as on the 2nd week, 1st, 2nd, 3rd and 6th month after the treatment.

Eligibility criteria:
inclusion criteria: * age between 20-80 year-old. * diagnosis was confirmed using an electrophysiological study exclusion criteria: * cancer * coagulopathy * pregnancy * inflammation status * cervical radiculopathy * polyneuropathy, brachial plexopathy * thoracic outlet syndrome * previously undergone wrist surgery or steroid injection for cts

Keywords: hydrodissection vitamin b12