Kornimate/medical-research-clean huggingface dataset:
effect of body position on hemodynamics in patients with acute ischemic stroke undergoing ultra-early reperfusion therapy

Conditions: Acute Ischemic Stroke

Summary: the aim of this study was to determine the differences in hemodynamics between different positions in patients undergoing ultra-early reperfusion therapy.

hemodynamic stability can prevent hypoperfusion or hyperperfusion after reperfusion therapy. it has been reported in a large number of literatures that body position has an effect on hemodynamics, but the effect of different body positions on the hemodynamics of patients undergoing ultra-early reperfusion therapy is not clear. in this study, we hypothesized that the hemodynamics of patients undergoing ultra-early reperfusion therapy would differ between different positions.

Eligibility criteria:
inclusion criteria: * age≥18 years, \< 80 years, regardless of sex； * patients with clinically confirmed acute ischemic stroke who received intravenous thrombolysis or emergency endovascular treatment; * baseline national institute of health stroke scale（nihss）score ≤25; * baseline glasgow coma scale (gcs) ≥8; * signed and dated informed consent is obtained exclusion criteria: * the patient has clear indications or contraindications, such as active vomiting, spinal cord injury； * clinicians considered that the assigned body position could not be maintained; patients unable to cooperate with all noninvasive beat-by-beat continuous bp monitoring; * poor temporal window penetration; * patients with diseases that seriously affect hemodynamics, such as atrial fibrillation, anemia, and hyperthyroidism; * previous history of atrial fibrillation or ecg showing atrial fibrillation or arrhythmia; * pregnant or lactating women; * poor treatment compliance; * complicated with severe systemic diseases, such as heart failure, respiratory failure, renal failure, gastrointestinal bleeding, coagulopathy, malignant tumors.
effectiveness of physical activity prescription among hypertensive patients of primary health care.

Conditions: Hypertension

Summary: the purpose of this study is to evaluate the effectiveness of a program to increase the physical activity of hypertensive patients using medical services and sports facilities of the mexican social security institute. the primary hypothesis to be proven is: the intervention will increase the proportion of hypertensive patients complying the physical activity minimum at week to get benefits on health in 20%, compare to patients in control group.

secondary hypothesis: the intervention achieved a significant change in the group of hypertensive patients in the following variables: 1. decreased levels of systolic and diastolic blood pressure, biochemical markers such as total cholesterol, triglycerides and fasting blood glucose and increased hdl cholesterol. 2. increase muscular endurance and cardio-respiratory capacity according to the categories of risk stratification. 3. decreased body weight, body mass index and waist circumference.

Eligibility criteria:
inclusion criteria: * diagnosed with high blood pressure \<5 years of evolution and / or without use of drug therapy to treat that condition; * with low levels of physical activity (pa) or physically inactive (less than 150 minutes of pa at week, intensity moderate to vigorous); * with availability to pa practice or considering begin to pa practice within the next six months (contemplation or preparation stages of the transtheoretical model). * without cardiovascular risk (assessed previously); * without physical or mobility problems that impede pa practice; * willingness to participate in the study, fulfill with outlined activities to develop the proposal. exclusion criteria: * high-risk patients according to the risk stratification of the american college of sports medicine; * fulfill the high recommendation of physical activity (more than 300 minutes per week of moderate to vigorous intensity);

Keywords: physical activity hypertension scheme reference primary care
family health team high-intensity interval training

Conditions: Type 2 Diabetes

Summary: with the rapid shift to virtual care, this pilot study aims to determine the feasibility of prescribing low-duration, interval-based training through virtual care. if successful, this study will inform a larger randomized control trial to determine if the prescription of low-duration interval-based training improves chronic disease through the measurement of hemoglobin a1c (hba1c), and weight to a greater extent than the general guideline to aim for 150 minutes of pa weekly.

dr. fernando will invite patients to participate in this trial during their virtual diabetes appointments at the east elgin family health team (eefht). participants will be randomized 1:1 using computer-generated randomization software to receive either a population-based, standard activity intervention (control group) or a high-intensity interval training (hiit) intervention, which they will complete on their own time, at the location of their choosing (at home, gym, outside, or elsewhere). data will be collected at baseline (t1), and participants will be followed up after 3 months (t2) and 6 months (t3). all data acquisition is from standard of care (i.e. patients are already seen every 3 months for diabetes visits). data collection at t1, t2 and t3 will include: * weight and height (measured using the health-o-meter weigh scale, used to calculate bmi) * minutes of pa (self-reported by participants using the log books designed for this study) * hba1c (requisition will be provided by dr. fernando. patients will be exempt from completing the baseline hba1c if they have had a hba1c measurement in the past 30 days \& the patient has not made significant lifestyle changes or had any blood glucose medications changed; in this case, the measurement completed in the past 30 days will be used as the baseline measure) * blood glucose and blood pressure medications

Eligibility criteria:
inclusion criteria: * adults, at least 18 years of age * non-pregnant * having a diagnosis of type 2 diabetes in accordance with the 2018 diabetes canada clinical practice guidelines * capable of consenting * deemed capable and safe to exercise by their physician (dr. fernando) * without a medical history of myocardial infarction in the past three months. exclusion criteria: * \< 18 years of age * pregnant * not having a type 2 diabetes diagnosis * having a medical history of myocardial infarction in the past 3 months

Keywords: hba1c virtual care blood glucose physical activity hiit
reversal of heparin in patients undergoing percutaneous coronary intervention (pci)

Conditions: Percutaneous Coronary Intervention; Coronary Artery Disease (CAD); Angioplasty

Summary: the study investigates the safety and efficacy of pmx-60056 for the reversal of heparin in patients undergoing percutaneous coronary intervention (pci)

pmx-60056 is being developed as a rapid and effective reversal agent for use in those situations where anticoagulation by heparin, or lmwh must be quickly stopped. potential uses include reversal of anticoagulation induced to prevent clotting during surgical procedures, and rescue from cases of inadvertent or unexpected overdose.

Eligibility criteria:
inclusion criteria: 1. the patient will undergo pci for diagnostic and/or therapeutic purposes with a procedure that uses anticoagulation before the instrumentation and reversal of anticoagulation immediately after the procedure. 2. male or female patients of any race, aged 18-80 years old. 3. the patient will be anti-coagulated with unfractionated heparin. 4. the patient is medically stable and physically and mentally able to participate in this study. 5. the patient has given written informed consent to participate in this study after fully understanding the implications and constraints of the protocol. exclusion criteria: 1. the patient requires emergency surgery under conditions which prevent compliance with this protocol or which might cause unacceptable risk to the patient. 2. the patient requires any concomitant surgical procedures (e.g., carotid artery, cabg) during the pci. 3. the patient has received any investigational drug within 30 days of study enrollment, or has had any prior exposure to pmx-60056. 4. the patient has any condition or abnormality which may, in the opinion of the investigator, compromise the safety of the patient. 5. the patient is pregnant or breast feeding. 6. the patient is of childbearing potential and not under adequate contraceptive protection. 7. the patient has a history of clinically significant hematologic disease including heparin-induced thrombocytopenia, bleeding disorders, or platelet count \<100,000. 8. severe impaired hepatic function (sgot, sgpt \>2 x uln). 9. history of aids, ± hiv. 10. history of allergy to heparin (beef or pig), protamine, or salmon. 11. history of chronic alcohol or drug abuse within the last one year.

Keywords: percutaneous coronary intervention heparin angioplasty lmwh
total lymphoid irradiation (tli) to prevent focal segmental glomerulosclerosis (fsgs)recurrence in the renal graft

Conditions: Glomerulosclerosis, Focal

Summary: the purpose was study the immunosuppression using total lymphoid irradiation plus csa, mmf and prednisone pretransplant to prevent focal segmental glomerulosclerosis recurrence in the renal graft

focal and segmental glomerulosclerosis (fsgs) is resistant to treatment with immunosuppressants and after transplant, 40% of such patients have recurrences in renal allograft. the purpose of this trial was to use total lymphoid irradiation (tli) plus mycophenolate mofetil (mmf), cyclosporine a (csa) and prednisone (pred) to prevent recurrence.

Eligibility criteria:
inclusion criteria: * patients (age \> 18 years) * biopsy-proven primary fsgs * end-stage renal failure at presentation or prior allograft loss due to recurrent fsgs. * signed the informed consent before entering in the study. exclusion criteria: * age \< or equal 18 years * no biopsy-proven fsgs * without living donor to perform the transplant * no signed the informed consent

Keywords: glomerulosclerosis, focal pretransplant immunosuppression total lymphoid irradiation renal transplant recurrence
the effect of pregnancy and labour on the pelvic floor diagnosed with 3d and 4d ultrasound

Conditions: Obstetric; Injury Pelvic Floor

Summary: injuries to the pelvic floor muscles and fascias during delivery and childbirth may lead to urinary incontinence (25-45 %), faecal incontinence (11-45%), pelvic organ prolapse (7-23%), sexual dysfunction (15-33 %) and chronic pain syndromes (4-15%). pelvic floor muscle injuries are not easy to diagnose as they are not visible when looking at surface anatomy during a standard gynaecological examination. the investigators are therefore in urgent need of better tools to diagnose these injuries. having a reliable and easily accessible tool enables studies of the consequences of such pelvic floor muscle injuries. it also makes it possible for us to explore the effect of interventions such as pelvic floor muscle training and surgery in patients with and without pelvic floor muscle injuries. the investigators have previously presented data to support the reliability and the validity of the three and four dimensional (3 and 4d) ultrasound technique used to define pelvic floor muscle anatomy in healthy volunteers and have now a tool to study women before and after delivery. at the department of obstetrics and gynaecology, akershus university hospital there are approximately 4500 deliveries annually and 1500 women are giving birth for the first time. challenges: the invitation to participate in the study will be given to all women expecting their first child fulfilling inclusion criteria. the biggest challenges in the project will be logistical. to be able to inform, recruit and follow women having their first child is a challenge in it self. applications: if it is possible to identify a risk group for pelvic floor injuries before delivery, it might be ethical to recommend a prophylactic caesarean section to avoid disabling incontinence and prolapse later in life.


Eligibility criteria:
inclusion criteria: * women giving birth to their first child at akershus university hospital, norway * must understand spoken and written norwegian exclusion criteria: * previous pregnancy of more than 16 weeks * serious illness mother or child * birth before pregnancy week 32

Keywords: pelvic organ prolapse levator hiatus 3 and 4 dimensional ultrasound
post-traumatic headache multidisciplinary study

Conditions: Post-Traumatic Headache; Post-Concussion Syndrome

Summary: the study will investigate the effect of pharmacological preventive treatment, education, physiotherapy and psychological counselling on the headache and associated symptoms in patients refered to the danish headache center

pharmacological interventions are candesartan, amitritylin and gabapentin depending on the headache phenotype. in total 3 visits spanned over 1 year education is conducted as group sessions of up to 10 patients by two specialist nurses 2 x 90 min physiotherapy is conducted as group sessions of up to 5 patients by physiotherapists 8 x 60 min plus 2 individual sessions. psychology is conducted as group sessions of up to 10 patients by psychologist 3x60 min plus option of 1 individual session.

Eligibility criteria:
inclusion criteria: patients with post-traumatic headache - exclusion criteria: * medication-overuse headache
single-dose pharmacokinetics of bms-626529, administered as bms-663068, in subjects with hepatic impairment compared to healthy subjects

Conditions: Infection, Human Immunodeficiency Virus

Summary: a single oral dose study in subjects with hepatic impairment and healthy control subjects. subjects will stay at the clinical facility where interval blood samplings will be obtained and examined for drug effect.


Eligibility criteria:
inclusion criteria: * males and females, ages 18 to 70 years, inclusive * bmi: 18.5 to 38 kg/m2 * body weight great or equal to 45.5 kg * subjects with hepatic impairment * subjects with hepatic impairment must be on a stable dose of medication and/or treatment regimen * healthy subjects to the extent possible matched to the first four subjects with hepatic impairment with regard to age, body weight, and sex, as determined by no clinically significant deviation from normal in medical history, physical examination, ecgs, and clinical laboratory determinations exclusion criteria: * any major surgery within 4 weeks of study drug administration * donation of blood to a blood bank or in a clinical study (except a screening visit) within 4 weeks of study drug administration (within 2 weeks for plasma only) * subject has required additional medication for hepatic encephalopathy within 12 months (6 months for severe hepatic impairment) prior to dosing * presence of severe ascites or edema in subjects, as judged by the pi
a multifaceted intervention on reducing immunization errors

Conditions: Vaccines; Vaccines Adverse Reaction; Vaccine Practice

Summary: the goal of this trial is to reduce the general error related to vaccines and immunizations (composited on secondary endpoint), after 11 moths of folow-up after cluster randomization and stepped wedge on primary care on brazilian public health. the main questions it aims to answer are: 1. to evaluate the effectiveness of a multifaceted intervention in vaccination rooms in reducing vaccination errors. 2. to describe the rate of adverse events following immunization (aefi) and the associated factors.

researchers will compare two times in a stepped wedge design: 1. usual care :all sites will follow the standard practices for vaccine management and immunization in health units with vaccination rooms during 1 month. all sites will be randomized into 11 steps (corresponding to the number of stages required to complete the 12-month study). at each step, 8 clusters (each containing one immunization service within a primary care facility) will receive the intervention." 2. multifaceted strategy :\*this time will implement a multifaceted quality improvement and process strategy composed of: * video-based training on vaccine management. * development of an optimized cold chain manual, streamlining guidelines for vaccine handling. * technical documents providing comprehensive guidance on the appropriate management of vaccines and their respective immunization schedules. * technical documentsaddressing the management of errors identified post-vaccination and offering recommendations for public guidance.

Eligibility criteria:
cluster inclusion criteria * health units with vaccination rooms administering at least 2,000 doses of vaccines/immunobiologicals per month, cluster exclusion criteria * primary health units that do not provide consistent vaccination services to the population.

Keywords: cluster-randomized controlled trial multifaceted intervention quality improvement in immunization vaccination errors vaccination safety primary health care vaccination room management cold chain management public health improvement health systems implementation
efficacy and safety of silodosin in the treatment of lower urinary tract symptoms in taiwanese population.

Conditions: Human Trichinellosis

Summary: to evaluate the therapeutic effects and safety of silodosin in the patients of acute brain injury with lower urinary tract symptoms.

i.test drug 1. name: silodosin 8mg/capsule 2. dosage form: capsule (silodosin) 3. dose(s): 8mg 4. dosing schedule: oral, once daily 5. mechanism of action: silodosin blocks the α1a-adrenergic receptors in the prostate gland and urethra, causing smooth muscle relaxation. since the intraurethral pressure of the urethra is reduced, urine can pass more easily and the urinary symptoms are relieved. 6. pharmacological category: α1a-adrenergic receptor blocker ii.the process of the experiment (brief describe) eligible subjects will be randomized to a study medication according to the randomization schedule (a 1:1 randomization ratio). there are 2 groups in this study, with group a (treatment group, silodosin 8mg, once daily, 8-week duration) and group b (control group). iii. the primary endpoint is the rate of foley removal. the secondary endpoints are the rate of urinary tract infection, residual urine amount and the rate of re-on foley.

Eligibility criteria:
inclusion criteria: * subject ≥ 20 years of age * newly diagnosed of acute brain injury with foley insertion with 5 days exclusion criteria: * subjects with already in use of α1a-adrenergic receptor blocker used * subjects with urethral trauma * subjects with a history of prostate, penile, testicular, bladder, or urethral cancer or has received pelvic radiation, systemic chemotherapy, or intravesical chemotherapy * expected survival days for brain injury less than 28 days * subjects with a history of renal dysfunction (elevated creatinine (\>2.0 mg/dl)) * subjects with severe liver impairment (child-pugh score≧10) * subjects with cyp3a4 inhibitors (ketoconazole、clarithromycin、itraconazole、ritonavir) used * subjects with pregnancy * subject who has been in an investigational drug study in the past 3 months * subjects who is considered as ineligible for participation in this clinical study by the principle investigator or the co-investigator's judgement.
a retrospective investigation of local anesthetic concentrations in femoral nerve block

Conditions: Postoperative Pain

Summary: the purpose of this study is to retrospectively compare perioperative pain relief and safety in pediatric patients who have received a femoral nerve block with varying concentrations of local anesthetic.


Eligibility criteria:
inclusion criteria: * asa physical status i or ii * age \< or equal to 18 years of age at time of femoral nerve block * femoral nerve block performed from 2010-2015 exclusion criteria: * asa physical status \> ii * co-morbid diseases (cardiac, pulmonary, neurological disease) * use of adjunctive medications in femoral nerve block (except for epinephrine), such as dexamethasone

Keywords: femoral nerve blocks children knee and thigh surgery
boost study 21270 (cognition)

Conditions: Cognitive Function Abnormal

Summary: this study is designed to to test the technical feasibility of encouraging interaction with a mobile smartphone software package (mhealth app) for training aspects of executive function and cognition.

the purpose of this human subjects study is to test the technical feasibility of interaction with a mobile smartphone software package (mhealth app) for training in aspects of executive function and cognition. the study participants are healthy subjects recruited online, with consent secured at the time of screening, and with enrollees assigned to high or low groups on the basis of initial screening task scores. subjects are requested to participate in directed interaction activities for up to 8 weeks, with measures primarily evaluating feasibility of mhealth app package task completion and secondarily evaluating the cognitive effect of activities.

Eligibility criteria:
inclusion criteria: * age 18 years and above * fluent in english * resides in the united states * score on prescreen task is in 25% quartile * familiar with smartphone device app installation and device usage * possesses a compatible smartphone exclusion criteria: none

Keywords: cognition
radial head arthroplasty a clinical and radiological comparison of monopolar and bipolar radial head arthroplasty

Conditions: Radial Head Fracture; Elbow Fracture; Arthroplasty Complications

Summary: fractures of the radial head are among the most common fractures in the elbow and represent one-third of all elbow fractures.this retrospective cohort study was performed between 2004 and 2014 at sundsvall and umeå university hospital, sweden. all patients who were operated on between 2004 and 2014 with a radial head arthroplasty for an acute or sequelae due to a caput radii fracture.the aim of this study is to evaluate clinical or radiological differences between patients treated with a unipolar or bipolar radial head arthroplasty.


Eligibility criteria:
inclusion criteria: * all patients treated with a radial head arthroplasty during the study period. exclusion criteria: * none