Kornimate/medical-research-clean huggingface dataset:
information and anaesthesia in paediatrics

Conditions: Anxiety

Summary: this study aims to investigate whether detailed and illustrated information (comics) about anaesthesia reduce preoperative anxiety in children being subjects to craniotomy. children scheduled for craniotomy are randomized to groups receiving a comic leaflet explaining the course of anaesthesia before preanaesthesia visit or no intervention. preoperative anxiety is assessed with anxiety scale staic for the two groups of participants.


Eligibility criteria:
inclusion criteria: * male or female children between 6 to 16 years and 11 month old. * children scheduled to have a craniotomy or orthopaedic surgery (multi-level surgery, spinal decompression, osteosarcoma resection, column surgery , fibroid curettage, nuss bar procedure, hip varus surgery) or visceral and urologic surgery (intestinal continuity restoration, hypospadias surgery, bladder malformation, sarcoma). * children with a high, normal or light level of verbal comprehension (normal academic level or less than two repeating). * children coming with their parents. exclusion criteria: * previous surgery. * unwillingness to participate (parents or child)

Keywords: anxiety anaesthesia child rct elective surgery
the effect of having a child watch musical cartoons

Conditions: Child; Cartoon

Summary: the purpose of this study was to evaluate the effect of watching musical cartoons on anxiety and vital signs in children undergoing rectal irrigation. this study was a randomized controlled experimental trial. the study sample consisted of 40 children, 20 of whom were assigned to the experimental group and 20 to the control group. data collection form, vital signs evaluation form, and child anxiety scale-stateness were used as data collection tools. data collection tools were used in both groups before, during, and after the procedure. in addition, the experimental group was shown musical cartoons during the procedure.

the present study was conducted as a randomized controlled experimental study to investigate the effect of watching musical cartoons on anxiety and vital signs in children undergoing rectal irrigation. does watching musical cartoons during rectal irrigation have an effect on children anxiety and vital signs? the answer to the question has been sought.the study sample consisted of 40 children aged 4-10 years who met the inclusion criteria and whose parents provided written and verbal consent for their participation in the study after being informed at the pediatric surgery and pediatric urology department of a public hospital affiliated to the provincial health directorate of the ministry of health in istanbul. because of the high power requirement and the potential for loss to follow-up, the study was conducted with a total of 40 children, 20 assigned to the experimental group and 20 to the control group, who met the eligibility criteria and consented to participate. the children were randomly assigned to the control or experimental group. children enrolled in the study were assigned to the experimental or control group using the https://www.calculatorsoup.com. data collection form, child anxiety scale-stateness, and vital signs evaluation form were used as data collection tools.after obtaining institutional approval and written consent from parents after informing them and their children, data were collected by the investigators through a face-to-face interview that took approximately 11-20 minutes per child. the intervention to be applied to the experimental group was carried out by the investigator after informing the children and parents and obtaining their written consent.

Eligibility criteria:
inclusion criteria: * children aged 4-10 years * children who can count from one (1) to ten (10). * children who love cartoons with music. exclusion criteria: * children without visual or hearing impairments * children without mental problems

Keywords: anxiety child musical cartoons vital signs
a registered cohort study on neurodegenerative associated with sleep disorder.

Conditions: Neurodegenerative Disorder

Summary: cognitive impairment often appears in neurodegenerative diseases, and it is expected to further study the mechanism of sleep disorders associated with the progression of neurodegenerative diseases by exploring the clinical manifestations, imaging, and biological marker changes of sleep disorders in neurodegenerative diseases.


Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of neurodegenerative disease. 2. patients experience insomnia, excessive drowsiness, or confusion at night. 3. patients experience frequent awakenings, daily sleep episodes, or nocturnal confusion. 4. the presence of one or more of the following characteristics: a. wandering at night with inappropriate activity; b. agitation, combativeness; c. confusion, disorientation, or marked delirium. 5. polysomnographic monitoring showed the following two conditions: a. poor sleep efficiency, increased number and duration of awakenings; b. multiple sleep latency tests showed increased daytime sleepiness. 6. presence of other medical symptoms that do not indicate the primary disease. 7. other sleep disorders (e.g., periodic limb movement disorders, obstructive sleep apnea syndrome) may be present, but do not explain the patient 's main symptoms. 8. any of the above can be diagnosed exclusion criteria: 1. patients with other neurological disorders. 2. pregnant or lactating women.
determining the effect of breathing exercise applied to children aged 6-12 before enema on anxiety, fear and pain

Conditions: Constipation; Distention; Child, Only

Summary: in this study, it was aimed to determine the effect of breathing exercise applied before the enema procedure, which causes fear, pain and anxiety in children aged 6-12 years who applied to the pediatric emergency service, on fear, pain and anxiety in children. this research is in pretest-posttest, parallel group, randomized controlled experimental design. the universe of the research consists of children aged 6-12 years who applied to the pediatric emergency department of iğdır state hospital (turkey) between may 2022 and june 2022.

in this study, it was aimed to determine the effect of breathing exercise applied before the enema procedure, which causes fear, pain and anxiety in children aged 6-12 years who applied to the pediatric emergency service, on fear, pain and anxiety in children. this research is in pretest-posttest, parallel group, randomized controlled experimental design. the universe of the research consists of children aged 6-12 years who applied to the pediatric emergency department of iğdır state hospital (turkey) between may 2022 and june 2022. in the study, the pre-test scores of the pain, fear and anxiety levels of the children were compared and it was found that the pain, fear and anxiety levels of the intervention and control groups were moderate, and there was no difference between the groups. this result is important in terms of evaluating the effectiveness of the initiative. in the study, a significant difference was found between the pain, fear and anxiety levels of the intervention and control groups after breathing exercise. accordingly, the pain, fear and anxiety levels of the intervention group were significantly lower than the control group.

Eligibility criteria:
inclusion criteria: * being between 6-12 years of age * administering an enema because of constipation or distension * there should be no obstacle to the enema procedure * child and parent agree to participate in the study exclusion criteria: * having a mental disability * having any problems with hearing, vision, hearing * taking analgesics within the last 6 hours * having an additional illness that may cause pain removal criteria were as follows: * developing complications during the enema procedure (intestinal perforation, bleeding, etc.)

Keywords: children enema anxiety fear pain breathing exercise
evaluation of a personcentered internet-based cbt program for stress, anxiety and depressive symptoms in patients with cardiovascular disease

Conditions: Cardiovascular Disease; Psychological Distress

Summary: to evaluate a nine-week adaptable and person-centred i-cbt program that can be directed towards stress, anxiety and depressive symptoms in persons with cvd.

all patients diagnosed as cvd (i.e. diagnosis ischemia (icd-code i20., i25.), heart failure (icd-code i50., i42.) or arrhythmia (icd-code i48, i49, df016) and who received care in the last 12 months at hospitals in the south-east of sweden will be contacted by letter with information about the study. participants who are interested are invited to visit our website for more information, registration and provision of informed consent. after registration, participants will respond to questions about demographics, medical history, stress, anxiety and depressive symptoms on the website. inclusion or exclusion will be assessed by a group consisting of a psychologist, cardiology specialist nurse and a psychiatry specialist nurse. before final inclusion and randomization eligible participants will be contacted for a telephone interview held by the study nurses. included (n=400) participants will, on our website (www.xxxxxx), complete the baseline study questionnaires and then be randomized according to a 2 x2 factorial design.

Eligibility criteria:
inclusion criteria: * age 18 years and above * treatment for cardiovascular disease (cvd) according to european society of cardiology guidelines * stable cvd (new york heart association class i-iii) and not having been hospitalised for cvd in in the last four weeks. * stress (perceived stress scale (pss)-10\>13 points) and/or * anxiety (i.e. general anxiety disorder scale (gad) ≥5 points) and/or * depressive symptoms (patient health questionnaire-9 28 (phq-9) \> 5 points) exclusion criteria: * severe cvd (new york heart association classification iv) or another severe chronic life-threatening disease * severe stress, anxiety or depression assessed as requiring acute treatment * not being able to dedicate 3-4 hours per week to participate in the program

Keywords: cardiovascular disease psychological distress internet-based cognitive behavioural therapy
the confirmatory study of tau-284 in pediatric patients with perennial allergic rhinitis

Conditions: Perennial Allergic Rhinitis

Summary: the objectives of this study are: to confirm the superiority of tau-284 over placebo after two weeks of administration to pediatric patients with perennial allergic rhinitis and to investigate safety of tau-284.

this is a randomized, double-blind, placebo-controlled, 2-arm parallel-group comparative study to confirm the superiority of tau-284 over placebo after two weeks of administration of tau-284 (20 mg/day) or placebo to pediatric patients with perennial allergic rhinitis, with "the change from baseline in total nasal symptom score (total score for the three major nasal symptoms \[sneezing, rhinorrhea, and nasal congestion\])" as the primary endpoint; and to investigate safety of tau-284.

Eligibility criteria:
inclusion criteria: * patients aged between 7 and 15 years * patients who have received a diagnosis of perennial allergic rhinitis according to the diagnostic criteria * patients with a mean rhinorrhea score and a mean sneezing score of at least 2 on the basis of symptoms recorded in the nasal allergy diary during the observation period etc. exclusion criteria: * patients with vasomotor rhinitis or eosinophilic rhinitis * patients who have concurrent nasal disease that may affect the efficacy of tau-284 * patients with a history of any of the nasal surgical procedures * patients who have a positive result for pollen antigens which are dispersed during the study period * patients who have a positive result for dog dander or cat dander antigen and have a chance to touch dogs or cats. * patients with current or previous history of drug allergy * patients who concurrently have renal function abnormalities that may cause safety problems etc.

Keywords: tau-284 bepotastine besilate histamine h1 receptor antagonists children
a study on the effects of dextrose solutions on the course of labor

Conditions: Labor

Summary: the purpose is to determine in term nulliparas with singletons that present in active labor (3-5 cm) or with ruptured membranes whether the administration of dextrose solutions to normal saline improves or expedites the course of labor. the researchers' hypothesis is that the addition of a carbohydrate substrate will shorten the length of labor and facilitate a vaginal delivery.

factors that affect the course of labor have been studied extensively. surprisingly, there is little data on the effect that different types and rates of intravenous (iv) fluids have during labor. exercise physiologists have shown that increased fluid intake and carbohydrate replacement improve skeletal muscle performance in prolonged exercise. in a 1992 randomized, controlled study comparing iv fluid rates, garite et al. showed a lower frequency of prolonged labor, and possibly a decreased need for oxytocin, with higher iv fluid rates in labor. inadequate hydration may contribute to dysfunctional labor and possibly an increased rate of cesarean section. we propose that inadequate carbohydrate replacement in labor may also contribute to prolongation of labor and increased need for operative delivery. glucose is the main energy supply for the pregnant uterus. physiological requirements for glucose during labor are approximately 10 grams per hour. adequate supplies of glucose are needed to maintain exercise tolerance and muscle efficiency, which are important factors in the progress of labor. dysfunctional labor or dystocia, which is the leading indication for primary cesarean delivery, is caused by uterine forces insufficiently strong or inappropriately coordinated to efface and dilate the cervix. dystocia can also be a result of inadequate voluntary muscle effort in the second stage of labor. it contributes to increased risk for chorioamnionitis, which is a leading cause of maternal and fetal morbidity and mortality. supplying carbohydrate fuel for working uterine and skeletal muscle may improve progress in labor and, therefore, diminish risk for chorioamnionitis and need for cesarean delivery.

Eligibility criteria:
* primiparous * singleton gestation * vertex presentation * spontaneous active labor with or without pitocin augmentation * gestational age \> 36 weeks * cervical dilation 3 to 5 cm with or without ruptured membranes exclusion criteria: * multiparous * pregestational or gestational diabetes mellitus * preeclampsia at admission * previous cesarean section * non-vertex presentation * multiple gestation * chorioamnionitis at admission * intrauterine growth restriction (\< 10th percentile) * patients admitted for induction

Keywords: labor carbohydrate dystocia
t3ai-pain after breast surgery

Conditions: Pain; Breast Diseases

Summary: current standard of care for post-operative analgesia after breast surgery in cdha is tylenol #3® (300 mg acetaminophen, 30 mg codeine, 15 mg caffeine per tablet). we are proposing to test the analgesic efficacy of acetaminophen plus ibuprofen against tylenol #3® in patients undergoing outpatient breast surgery.

block randomization will be used to randomize patients to one of two combinations. group a will receive capsules containing 650 mg acetaminophen plus 400 mg ibuprofen. group b will receive capsules containing 600 mg acetaminophen, 15 mg caffeine and 60 mg codeine. capsules are placed in identical dossettes containing a seven day supply. patients are instructed to start taking their medications post-op and continue until they are pain free. all participants are given a series of blank visual analogue scales and likert scales and instructed to record their level of pain intensity and pain relief four times per day for the entire week. peri-operative pain management will be standardized. patients will not receive pre-operative analgesics. intra-operative analgesia will be intravenous opioids as selected by anaesthesiology. no local/regional anaesthesia will be used. intravenous ketorolac will not be allowed for trial participants. all patients will receive intravenous opioid and anti-emetic if required in pacu. any patients with peri-operative complications or other problems requiring admission or alternative analgesics will be excluded.

Eligibility criteria:
inclusion criteria: * ages 18 to 70 inclusive * outpatient breast surgery: lumpectomy; mastectomy, simple or modified; with or without sentinel lymph node biopsy, axillary node dissection. exclusion criteria: * allergies to acetaminophen, nsaids, asa or codeine. * asthma. * recent reported history of upper gi bleeding. * daily analgesic use (otc or opioid) pre-operatively. * any opioid use in the week prior to surgery. * reported history of pud if not on ppi regularly. * anticoagulant use (low dose asa excepted). * renal disease or impairment. * reported history of liver disease. * pregnancy. * major operative complications. * patients requiring admission. * communication barrier. * cognitive or memory impairment. * reported history of drug and/or alcohol abuse.

Keywords: randomized controlled trial clinical trial breast tumor surgery outpatient surgery analgesia outpatient analgesia post surgical analgesia ≥ 18 and ≤ 70 years of age elective outpatient breast surgery for: lumpectomy/quadrantectomy +/- sentinel lymph node biopsy lumpectomy/quadrantectomy with axillary node dissection simple mastectomy +/- sentinel lymph node biopsy modified radical mastectomy
cognate patient care insight scale

Conditions: Schizophrenia

Summary: schizophrenia is a disease of young adults that affects 1% of the general population. according to numerous studies, it has been estimated that between 50% and 80% of patients with schizophrenia do not consider to have a mental disorder and are therefore not aware of their disorders. a poor degree of insight is associated with poor compliance, a higher number of re-hospitalizations, altered social and relational functioning, and a higher number of suicides and violent behaviors. this is why insight, which is an essential dimension of psychopathology, must be evaluated, as it depends to a large extent on the therapeutic alliance, adherence to treatment, likelihood of relapse and prognosis.

evaluation (test, re-test) this new tool for assessing insight will allow for a discrepancy in assessment and a more refined assessment with a view to developing specific care for the patient and / or the relative with regard to the three dimensions evaluated: disease, treatment and functional implications

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia * age from 18 to 50 years old * stabilized clinical condition (without therapeutic modification during the month prior to inclusion) * french language read, spoken and understood (patient and family member) * having given his consent * agreement of the guardian for persons under guardianship * consent of the relative exclusion criteria: * refusal of patient or legal guardian * refusal of the loved one * patient and / or neurological disorder of neurological origin of vascular, infectious or neurodegenerative origin
diffusion weighted magnetic resonance imaging of brain in monochorionic twin pregnancies with demise of one fetus

Conditions: Twin Pregnancy With Antenatal Problem

Summary: diffusion weighted imaging (dwi) can reflect the microstructure and pathological changes of tissue, and diffusion tensor imaging (dti) can quantitatively evaluate the fine structure of white matter in brain. in this study, conventional and diffusion-weighted mri (dwi, dti) sequences were used to analyze the brain of monochorionic twin pregnancies with demise of one fetus.

with the incidence rate of twin pregnancy increasing, the incidence of intrauterine death of twin pregnancies is also rising, which has great impact on the morbidity and mortality of the other fetus, and increases the mortality of fetal survival, premature birth, brain damage and long-term sequela. therefore, it is necessary to examine the central nervous system of the surviving fetus of twin pregnancy and intrauterine death. when the surviving fetus is complicated with nervous system abnormalities, conventional mri can generally make a diagnosis. however, some of the surviving fetuses may not find other structural or echo abnormalities on b-mode ultrasonography, and even these fetuses do not find structural or signal abnormalities on routine mri examination. whether the surviving fetuses may have brain abnormalities cannot be detected early by the above methods. diffusion weighted imaging (dwi) can reflect the microstructure and pathological changes of tissue, and diffusion tensor imaging (dti) can quantitatively evaluate the fine structure of white matter in brain. the present study is to use conventional sequence and diffusion-weighted imaging (dwi, dti) to analyze the brain of monochorionic twin pregnancies with demise of one fetus, which aims to find the potential brain abnormalities early and provide some guidance for the clinical diagnosis and treatment in the next step.

Eligibility criteria:
inclusion criteria: 1. twin pregnancy was diagnosed and one fetus died in utero 2. twin pregnancy with one abnormal fetus 3. singleton pregnancy with abnormalities outside the fetal brain exclusion criteria: 1. those who can't cooperate with mri examination, such as those who have metal, claustrophobia or can't insist on scanning. 2. pregnant women with gestational age less than 20 weeks.

Keywords: twin pregnancy demise of one fetus diffusion weighted imaging diffusion tensor imaging
bryophyllum vs. nifedipine

Conditions: Tocolysis

Summary: in a prospective, randomised study the efficacy and tolerability of bryophyllum p. (p.o) vs. nifedipine (p.o) will be proofed in a defined group of pregnant women with threatened preterm labour.


Eligibility criteria:
inclusion criteria: * female exclusion criteria: * bishop score \> 5

Keywords: bryophyllum p. nifedipine tocolysis