Kornimate/medical-research-clean huggingface dataset:
refined nursing in rehabilitation training

Conditions: Brain Injuries

Summary: this study is to explore the clinical effect of refined nursing in rehabilitation training for patients with brain injury during the recovery period. patients in the control group were provided with routine nursing intervention, while patients in the study group adopted a nursing mode based on the concept of refinement treatment. comparison was made in terms of the glasgow coma scale (gcs) score, cognitive function score, functional independence score, nursing satisfaction, and incidence of complications.

this study is to explore the clinical effect of refined nursing in rehabilitation training for patients with brain injury during the recovery period. the subjects of the study were 96 patients with severe traumatic brain injury (tbi). according to the order of visits, there were 48 patients in the study group and the control group, respectively.patients in the control group were provided with routine nursing intervention, while patients in the study group adopted a nursing mode based on the concept of refinement treatment. comparison was made in terms of the glasgow coma scale (gcs) score, cognitive function score, functional independence score, nursing satisfaction, and incidence of complications.

Eligibility criteria:
inclusion criteria: * patients diagnosed with severe tbi through imaging examinations such as head ct and magnetic resonance imaging * patients with surgical indications * patients with glasgow coma scale (gcs) ≤8 points * patients with complete clinical data * patients with written informed consent provided by family members exclusion criteria: * patients with organic lesions of major organs such as liver and kidney * patients with contraindications for surgery * patients with primary diseases such as cerebral hemorrhage and cerebral infarction * patients with combined or multiple injuries * patients with respiratory failure * patients whose family members had cognitive impairment or abnormal mental behaviors

Keywords: refined nursing coma rehabilitation training
acute mechanical response to anti-arrhythmic drug therapy

Conditions: Arrhythmias

Summary: the aim of this study is to determine if anti-arrhythmic drugs with a sodium channel-blocking mechanism exert a detrimental electromechanical effect on cardiac function in patients depending upon baseline intraventricular conduction and left ventricular function.

amiodarone therapy is used frequently for control of ventricular arrhythmias in patients who receive painful shocks from an implantable cardioverter-defibrillator (icd). data in post-myocardial infarction (mi) patients and icd patients suggest that amiodarone is mortality-neutral; it neither confers increased nor decreased mortality. however, these data are derived from patients largely with normal intraventricular conduction, manifesting as a qrs complex duration on the surface ecg \ 120 ms is indicative of abnormal depolarization, amiodarone may not be benign in patients with such conduction defects. patients with cardiac resynchronization therapy-defibrillators (crt-d), who all have abnormal baseline intraventricular conduction, may therefore be adversely affected by amiodarone. anecdotal clinical data suggest that this may be the case, but the question of amiodarone's cardiac safety profile in crt patients has never been studied.

Eligibility criteria:
inclusion criteria: * implanted cardiac device requiring generator change and a new device * able to give informed consent exclusion criteria: * current membrane-active anti-arrhythmic * glomerular filtration rate (grf)\<30 milliliters (ml)/min * map\<60 mmhg * known intolerance to procainamide * pregnancy * age \ 85 years old * baseline qt interval \>480 ms (500 ms if paced)

Keywords: anti-arrhythmic therapy
antibiotic resistance and microbiome in children aged 6-59 months in nouna, burkina faso

Conditions: Child Development

Summary: the use of antibiotics has saved millions of human lives, however consumption of antibiotics can select for antibiotic resistant organisms and may lead to changes in commensal microbiome. this study is designed to estimate the effect of antibiotic consumption on microbiome in a rural region of rural burkina faso. changes in the intestinal and nasopharyngeal microbiome and resistome following a short course of antibiotics will be measured.

this study is designed to better understand the effect of a short course of antibiotics on changes in intestinal and nasopharyngeal microbiome on treated children and untreated household contacts. the investigators hypothesize that a short course of antibiotics will lead to decreased bacterial diversity shortly after completion of the antibiotic course, and higher probability of identification of bacterial resistance genes in rectal and nasopharyngeal samples. the investigators hypothesize that a 5-day course of antibiotics (azithromycin, amoxicillin, or co-trimoxazole) will lead to significantly decreased intestinal and nasopharyngeal bacterial diversity among children aged 6-59 months. specific aim 1. determine the effect of treatment with antibiotics on microbiome diversity in children aged 6-59 months following a 5-day course of antibiotics. specific aim 1a. determine the direct effect of a 5-day course of azithromycin, amoxicillin, or co-trimoxazole on intestinal and nasopharyngeal bacterial diversity in children aged 6-59 months compared to no treatment. specific aim 1b. determine the indirect effect of antibiotic treatment of children in a household on intestinal and nasopharyngeal bacterial diversity in an untreated child aged 6-59 months. specific aim 1c. assess the association between intestinal bacterial diversity and anthropometry in a population-based sample of children.

Eligibility criteria:
inclusion criteria: * households will be eligible for inclusion in the study if they have 2 or more children aged 6 months to 59 months currently residing in the household. children from the household will be eligible if they are 6-59 months of age and are not currently receiving antibiotic treatment exclusion criteria: * children who are allergic to any of the study antibiotics will be excluded. individuals aged under 6 months and 5 years or older will be excluded. children already receiving antibiotics for an ongoing disease will be excluded.

Keywords: infection azithromycin amoxicillin co-trimoxazole trachoma mass treatment
combination hormone therapy followed by radiation therapy in treating patients with prostate cancer

Conditions: Prostate Cancer

Summary: rationale: androgens can stimulate the growth of prostate cancer cells. hormone therapy using triptorelin and flutamide may fight cancer by reducing the production of androgens. it is not yet known whether giving hormone therapy for 4 months is more effective than giving therapy for 8 months prior to radiation therapy for prostate cancer. purpose: randomized phase iii trial to study the effectiveness of combination hormone therapy for 4 or 8 months followed by radiation therapy in treating patients with prostate cancer.

objectives: i. compare the efficacy of 4 months vs 8 months of luteinizing hormone-releasing hormone (lhrh) agonist therapy combined with antiandrogen therapy prior to radiotherapy, in terms of disease-free survival and overall survival, in patients with stage i-iv localized invasive prostate cancer. outline: this is a randomized study. patients are randomized to one of two treatment arms. all patients receive triptorelin im once a month and oral flutamide three times daily with meals. patients randomized to arm i receive this therapy regimen for 4 months. patients randomized to arm ii receive this therapy regimen for 8 months. all patients then undergo radiotherapy 5 days a week for 7 weeks within 2 months of the last injection of triptorelin and within 1 month of the last oral flutamide tablet. patients are followed every 3 months after radiotherapy. projected accrual: a total of 276 patients (138 per treatment arm) will be accrued for this study.

Eligibility criteria:
disease characteristics: histologically confirmed invasive adenocarcinoma of the prostate stage i or ii (psa greater than 20 or gleason score at least 7) or stage iii or iv (any psa, any gleason) histologically confirmed benign nodal status no distant metastases patient characteristics: age: 18 and over performance status: karnofsky 60-100% life expectancy: not specified hematopoietic: not specified hepatic: not specified renal: not specified other: no other prior malignancy except nonmelanoma skin cancer no other uncontrolled illness that would prevent compliance prior concurrent therapy: biologic therapy: not specified chemotherapy: not specified endocrine therapy: no prior or other concurrent hormonal therapy radiotherapy: not specified surgery: no prior treatment other than transurethral prostatectomy no prior orchiectomy

Keywords: adenocarcinoma of the prostate stage i prostate cancer stage iib prostate cancer stage iia prostate cancer stage iii prostate cancer stage iv prostate cancer
a feasibility study to identify t-cell responses to neo-epitopes in tumor invaded lymph nodes (neoepitope)

Conditions: Breast Cancer; Cutaneous Melanoma

Summary: feasibility study for a method allowing identification of tumor mutated epitopes in patients with breast cancer or cutaneous melanoma, and quantification of cd8+ t cells specific for these tumor neo-antigens in their lymph nodes


Eligibility criteria:
inclusion criteria: patients over 18 years patient with hr+ , her2- and node-positive (proven by cytology) invasive ductal carcinoma breast cancer, grade (sbr) ii or iii, and having an axillary dissection programmed, or patient having cutaneous melanoma scheduled for a lymph node dissection at the institut curie including dissection of the lymph nodes draining the tumor, voluntary having signed and dated written informed consents prior to any specific study procedure, exclusion criteria: patients treated for a breast cancer who received neoadjuvant chemotherapy patients treated for breast cancer with distant metastases (m+)• only for patients with breast cancer: oral or systemic corticosteroids treatment received within 30 days prior surgery patients on immunosuppressive treatment or diagnosed of an immunodeficiency patients with known chronic viral infection as hiv1 or 2, hbv, hcv patients with other cancer diagnosed within 5 years (except squamous cell cutaneous carcinomas) patients without a french social security patients deprived of liberty or placed under the authority of a tutor

Keywords: breast cancer cutaneous melanoma
evaluating pcsk9 binding antibody influence on cognitive health in high cardiovascular risk subjects

Conditions: Dyslipidemia

Summary: this study evaluated change over time in neurocognitive testing in patients receiving statin therapy in combination with evolocumab (amg 145), compared with patients receiving statin therapy in combination with placebo.

participants who were enrolled in study 20110118 (fourier; nct01764633) at select sites in select countries (selected based on study start-up timelines) were invited to participate in this cognitive function study, 20130385. there was no separate randomization for study 20130385; data were analyzed according to study 20110118 randomized treatment arm.

Eligibility criteria:
inclusion criteria: * randomized into study 20110118 (fourier; nct01764633) exclusion criteria: * current or known past diagnosis of dementia or mild cognitive impairment (mci)

Keywords: high cholesterol treatment for high cholesterol lowering cholesterol lowering high cholesterol hypercholesterolemia
dialysis membranes and hemodynamic tolerance

Conditions: Dialysis Membranes and Hemodynamic Tolerance

Summary: background: high- and low-flux dialysis membranes made of different materials may correlate with various hemodynamic tolerance profiles. this study aims to investigate hemodynamic response and incidence of hypotensive episodes by comparing some of the most commonly used high- and low-flux dialyzers. methodology: the study was designed as an open label, randomized, cross-over investigation, including 25 patients undergoing chronic hemodialysis. four polysulfone dialyzers of 1.8 m2, a (revaclear, gambro), b (helixone high flux, fresenius), c (xevonta, bbraun) and d (helixone low flux, fresenius), were compared with each other. the hemodynamic profile was assessed with a non-invasive technique and patients were asked to provide tolerance feedback through a questionnaire.


Eligibility criteria:
inclusion criteria: * age 18 and older * ability to understand the information presented and sign the informed consent * chronic hemodialysis for at least 8 weeks * stable dialysis prescriptions and modality in the 2 weeks prior to protocol implementation exclusion criteria: * mental illness; * inability to understand the information presented and sign the informed consent; * acute disease requiring hospitalization at the time of patient enrolment * pregnancy and breast feeding

Keywords: hemodynamics intradialytic hypotension subjective tolerance dialysis membranes high flux low flux hemodialysis
changes in retinal function after intravitreal ranibizumab for age-related macular degeneration

Conditions: Age-related Macular Degeneration

Summary: age-related macular degeneration, a leading cause of blindness, is caused by an abnormal growth of the vessels beneath the retina. ranibizumab (lucentis) is a new drug that inhibits the growth of new vessels and has recently been approved by fda for treating this condition. this study is carried out to evaluate the changes in retinal function after an injection of ranibizumab.

the functional changes of the retina can be recorded by an electroretinography (erg).

Eligibility criteria:
inclusion criteria: * age 45 years and above * clinical diagnosis of wet amd * first injection of ranibizumab protocol * best corrected visual acuity 20/32 - 20/320 * consent form obtained exclusion criteria: * previously treated wet amd patients * patients with other ocular diseases which can cause abnormal erg such as glaucoma, uveitis or retinitis pigmentosa, etc. * pregnancy * history of seizure

Keywords: age-related macular degeneration (amd) choroidal neovascularization membrane(cnvm) ranibizumab anti-vascular endothelial growth factor electrophysiology electroretinography
an exploratory study of treatment sensitivity and prognostic factors in a efficacy and safety study of mfolfox6 + bevacizumab versus mfolfox6 + panitumumab therapy in patients with chemotherapy-naïve unresectable advanced or recurrent colorectal cancer

Conditions: Colorectal Cancer

Summary: the purpose of this study is to investigate biomarkers which may be predictors of efficacy and safety of treatment with mfolfox6 + bevacizumab versus mfolfox6 + panitumumab therapy in patients with chemotherapy-naïve unresectable advanced or recurrent colorectal cancer.

the drug being tested in this study is called panitumumab. this exploratory study will investigate biomarkers which may be predictors of efficacy and safety of treatment with mfolfox6 + bevacizumab versus mfolfox6 + panitumumab therapy in patients with chemotherapy-naïve unresectable advanced or recurrent colorectal cancer. tumor tissue samples obtained from the participants who enrolled in the safety/efficacy study of panitumumab + mfolfox versus bevacizumab + mfolfox (paradigm study: nct02394795) and provided consent for this additional study will be used. mutations, amplification and rearrangement of predefined tumor-associated genes will be investigated using dna collected from tumor samples used for assessing ras mutations and plasma free dna collected before administration of cycle 1 and at the discontinuation of the protocol treatment in the main study.

Eligibility criteria:
inclusion criteria: (1) patients who are enrolled in the main study and personally provided written consent after adequately explained about the contents of the additional study exclusion criteria: (1) patients who are determined by the investigator or researchers to be not suitable for participating in the additional study

Keywords: metastatic colorectal cancer, panitumumab, mfolfox6, bevacizumab
the effect of beta-blockers in substance p levels and the swallowing function

Conditions: Beta Blockers; Swallowing Disorder; Substance P

Summary: a non-randomised, prospective study to assess the effects of beta-blockers on substance p levels and the swallowing function. the study is going to be carry out in the gastrointestinal physiology laboratory of the hospital de mataró (spain). all participants will be actively recruited from a linked hospital and primary care database. we include two groups: the first group (group 1) are participants taking beta-blockers and the second group (group 2) are participants not-taking beta-blockers.


Eligibility criteria:
inclusion criteria: - patients taking and not taking beta-blockers exclusion criteria: * participants with heat and neck or esophageal cancer * participants with stroke or neurological disease * participants with central nervous system disease * participants with concomitant treatment with angiotensin converting enzyme inhibitors (acei), angiotensin ii receptor antagonists (ara-ii), antipsychotics, dopamine agonists, capsaicine. * participants with severe clinical signs of aspiration, including oxygen desaturation ≥3%.
recovery optimization: adding tissue flossing to nerve glide on axillary web syndrome post mastectomy

Conditions: Axillary Web Syndrome

Summary: axillary web syndrome (aws) is a complication associated with breast cancer surgery, characterized by pain, functional limitation of the shoulder and decreased quality of life. there are several physical treatment options to reduce pain and improve the functionality of the upper limb in women with aws. this study evaluates the effectiveness of an early rehabilitation approach to prevent axillary web syndrome consisting in functional and proprioceptive re-education, manual lymphatic drainage and kinesio taping after breast cancer surgery.

tissue flossing for the upper limb involves wrapping a floss band, typically made of elastic material, around the targeted area to provide compression and create a shearing effect on the tissue. this technique is utilized to enhance mobility, reduce pain, and improve recovery. the procedure begins by wrapping the band around the upper limb, starting from the distal part of the limb and moving proximally, ensuring a snug but not overly tight application that allows for some movement. the band is usually left in place for approximately 2-3 minutes. physiologically, tissue flossing for the upper limb, often referred to as compression wrapping, plays a significant role in enhancing physiological functions by improving joint mobility and reducing pain. this technique involves tightly wrapping a stretchable band around a muscle or joint to create compression. the compression temporarily restricts blood flow, which, upon release, results in a rush of blood back to the tissues. this process enhances circulation, promoting nutrient delivery and waste removal from the affected area.

Eligibility criteria:
inclusion criteria: * women between the ages of 45 and 65 years with diagnosis of breast cancer underwent to quadrantectomy and axillary lymphadenectomy. * no change of arm size. * females only will participate in the study. * all patients have axillary web syndrome * all patients' relatives enrolled to the study will have their informed consent exclusion criteria: * metastatic disease, infections, past tvp, emboli. * lymphedema. * chemotherapy and radiotherapy. * pregnant women. * patients who suffer from mental or psychological problems. * patients who have psoriasis, liver disease, diabetes mellitus, hypertensive patients and cardiac -robleme * patients have genetic disease or deformity * who has previous injury or fracture in shoulder joint * rheumatoid arthritis * osteopenia * frozen shoulder * metastases of any kind * lymphedema, * a traumatic injury to the targeted upper extremity * a musculoskeletal disorder * taking any anticoagulants * had undergone bilateral breast cancer surgery * experienced locoregional recurrence * had vascular problems in the affected upper extremity

Keywords: mastectomy nerve glide tissue flossing
resin polymer (nusmile bioflx) compared to stainless steel crowns (3m espe) for restoration of primary molar teeth

Conditions: Dental Caries; Tooth Decay

Summary: the purpose of this research study is to test the effectiveness of two different crowns/caps on teeth for restoration of primary molar teeth. the two different materials of crowns are resin polymer and stainless steel crowns. these crowns are placed on the teeth to restore function and prevent further caries and infection.

there is a lack of literary evidence for assessment of the properties of bioflx crowns and their effect on clinical outcomes and parental satisfaction compared to traditionally available options including stainless steel crowns and zirconia crowns. hence, this study plans to assess the clinical performance and child and parental satisfaction of bioflx compared to the "gold standard" stainless steel crowns in pediatric patients.

Eligibility criteria:
inclusion criteria: * age: children age group 3-7 yrs old * primary molars affected with caries or hypoplastic defect. * occlusion: primary molar must have antagonist tooth. * consent of parent (legal guardians) and child assent for 7 years. * multi-surface dental caries observed in more than one tooth, in either side of the same arch (maxilla or mandible) or opposite arch (maxilla or mandible) * status: asymptomatic or symptomatic teeth with signs of reversible pulpitis exclusion criteria: * teeth with advanced stages of resorption (more than 2/3rd) * teeth exhibiting irreversible pulpitis. * teeth for which pulpotomy is done. * molar in infraocclusion * medically compromised children (asa 3 or 4) * history of grinding or pathological attrition * adverse gingival or periodontal conditions