Kornimate/medical-research-clean huggingface dataset:
developement and evaluation of serological assays for covid-19

Conditions: COVID-19

Summary: the primary objective of the study aims to evaluate serological assays of virus covid-19.

this is a retrospective monocentric study, which will include the patients who have hospitalized in ambroise paré hospital and have sampling sent to the laboratory of microbiology of the hospital between the 15 march 2020 and 30 september 2020.

Eligibility criteria:
inclusion criteria: * patient ≥ 18 years; * have molecular diagnosis of positive or negative result in covid-19 virus by the laboratory of microbiology in ambroise paré hospital; * have diagnosed of a viral infection in respiratory. exclusion criteria: - patient refusal.

Keywords: covid-19 serological assay
pain, inflammation and opioid craving

Conditions: Opioid-use Disorder

Summary: the goal of this study is to investigate the association between response to pain and opioid craving in people with opioid use disorder. in this study, adults with opioid use disorder will be randomized to one of two brief education sessions followed by an assessment of response to pain. investigators will test the association between response to pain and opioid craving.


Eligibility criteria:
inclusion criteria: * age 18 years or older; * diagnosis of opioid use disorder * chronic pain * ability to read and provide informed consent exclusion criteria: * major psychiatric or medical condition that would interfere with participation * current opioid withdrawal * currently receiving opioid analgesic medication for pain * recent history of myocardial infarction or other serious cardiovascular condition * current peripheral neuropathy, active vasculitis or severe peripheral vascular disease * systematic inflammatory or autoimmune disorder * admitted to current treatment episode on an involuntary status
feasibility of a mobile application to support reflection and dialog about strengths in people with chronic illness

Conditions: Chronic Disease; Rheumatic Diseases

Summary: self-management of chronic illness can be highly demanding and people need to mobilize their personal strengths in order to live well with their condition. a mobile application was designed in collaboration with people with chronic illness and health care providers with the aims to support awareness of patients' strengths and patient-provider dialogues that include strengths. the aim of the present study is to evaluate with mixed methods the perceived usefulness and usability of the application and potential effects of the application on patients.

in this pre-post design pilot study participants will be recruited from self-management courses for people with rheumatic diseases. before using the application participants will be asked to report their strengths in a written format. after using the mobile application to reflect on their strengths the participants will be interviewed about their experience of using the application and on the task of reflecting on their strengths. they will also be asked to fill out a questionnaire on perceived usefulness and user-friendliness. before and after using the application the participants fill out questionnaires on emotions (positive and negative affective scale) and self-efficacy (the arthritis self-efficacy scale). all interviews will be audio-taped and analyzed with a qualitative approach. descriptive analysis will be applied for quantitative data.

Eligibility criteria:
setting 1: inclusion criteria: * age of 18 years or older * can read and speak norwegian language * diagnosed with a chronic condition * participating or having recently participated in a learning and mastery or an outpatient rehabilitation program no exclusion criteria

Keywords: self-management health assets strengths mhealth feasibility
naltrexone and memantine effects on alcohol drinking behaviors

Conditions: Alcohol Drinking

Summary: the purpose of this study is to evaluate the combined effects of the study medications naltrexone and memantine on alcohol drinking behaviors.

participants will be randomized to receive a combination of naltrexone/memantine over a one week period and then participate in a laboratory session. during this session, participants are given an initial drink of alcohol followed by the choice to drink up to 12 more drinks over a three-hour period. these medications are hypothesized to reduce craving and number of drinks consumed prior to and after exposure to the initial drink of alcohol and during the three hour drinking period.

Eligibility criteria:
inclusion criteria: * ages 21-55 * able to read english at 6th grade level or higher and to complete study evaluations * regular alcohol drinker exclusion criteria: * individuals who are seeking alcohol treatment * medical conditions that would contraindicate the use of study medication * regular use of other substances

Keywords: alcohol drinking drinkers alcohol drinking memantine naltrexone alcohol dependence alcohol abuse alcohol-related disorders ethanol alcoholism
the effects of caffeine on pain-based pacing during a cycling time-trial

Conditions: Healthy

Summary: caffeine has been shown to consistently improve time-trial performance, warranting restrictions on consumption under regulation of the national collegiate athletics association (ncaa) and world anti-doping agency (wada). this ergogenic effect is not well understood, possibly occurring as a result of altered metabolism, improved strength, and/or reduced muscle pain. the hypothesis of altered metabolism has recently fallen out of favor while muscular strength has a tenuous relationship with endurance exercise performance. reductions in muscle pain have been observed during low and moderate intensity endurance exercise, and this may be the mechanism of caffeine's ergogenic effect. in lieu of reducing pain during high intensity exercise, caffeine significantly improves performance. therefore, caffeine appears to improve the amount of work that can be done for a given muscle pain rating, suggesting that participants may pace based upon sensations of muscle pain during endurance exercise. most time-trial exercise is conducted in a fixed distance manner, measuring the time it takes participants to cover a given distance. little research has been conducted on a fixed pain time-trial that would require participants to produce and sustain a given level of muscle pain while measuring the distance covered in an allotted time. a fixed pain time-trial could allow researchers to better understand the effect of pain on endurance performance. the purpose of this study is to examine the effects of caffeine on a fixed pain time-trial.


Eligibility criteria:
inclusion criteria: * caffeine naive (\<40mg per day) physically active 18-35 year old men with no contraindications to exercise. exclusion criteria: * people who do not match the gender, age or caffeine limits; * those with contraindications to exercise or who are not physically active

Keywords: physically active, 18-35 year old men
the study of ct scans and echo parameters in patients with pah

Conditions: Pulmonary Hypertension

Summary: current standard of the diagnosis and monitoring of phnt requiring combination of invasive and non-invasive tests. the goal of the study is to correlate data from ct scans, echocardiograms, right heart catheterization, pfts, sleep studies, and perfusion scans. the ultimate goal is to determine patterns of the pah disease processes.

the goal of our study is to correlate data from various non-invasive tests such as commuted tomography (ct) imaging, echocardiogram, pulmonary function tests, and other laboratory tests along with hemodynamic measurements from right heart catheterizations in these ild patients with pulmonary hypertension, as well as all other pulmonary hypertension. the ultimate goal is to determine patterns of the pah disease processes, as well as define optimal diagnostic modalities including in-hospital verses outpatient studies.

Eligibility criteria:
inclusion criteria: * pulmonary hypertension; * ild with pulmonary hypertension exclusion criteria: * non-ph

Keywords: pulmonary hypertension; ild; ct imaging; echocardiogram; hemodynamic measurements of rhc. pulmonary function tests
electrical dry needling versus iontophoresis in treating chronic unilateral knee osteoarthritis

Conditions: Osteoarthritis of Knee

Summary: the goal of this clinical trial is to compare the effects of electrical dry needling versus glucosamine sulfate iontophoresis on pain intensity level, functional ability, and knee range of motion in chronic unilateral knee osteoarthritis patients.

knee osteoarthritis (oa) is a chronic disease affecting 240 million people worldwide, with a higher prevalence in older adults. the disease leads to knee deformity, laxity, and ligament instability. dry needling, a new treatment modality, uses needle electrodes to deliver an electric current to the pain-generating trigger point, improving the physiological effects and analgesic and anesthetic effects. iontophoresis, a safer method of drug therapy, has shown to be more effective in pain reduction in knee osteoarthritic patients. the study aims to investigate the effect of electrical dry needling versus glucosamine sulfate iontophoresis on pain intensity level, knee function, and range of motion (rom) in chronic knee oa patients. this approach aims to maximize drug bioavailability, optimize therapeutic efficacy, and minimize side effects.

Eligibility criteria:
inclusion criteria: 1. the patient will be selected from the outpatient clinic of physical therapy at horus university, new damietta, egypt, diagnosed with a kellgren/lawrence grade 2,3 radiological severity of knee osteoarthritis (oa). and referred by an orthopedist. 2. age will range from 40 to 60 years. 3. body mass index will range from 25 to 29.9 kg/m2. 4. duration of knee pain not less than 3 months prior to study . exclusion criteria: 1. patients with history of cardiac disorder with pacemaker. 2. knee surgery. 3. diabetes and nutritional disorder. 4. neuromuscular and other musculoskeletal diseases. 5. any red flags to dry needling, or conventional therapy. 6. had received physical therapy, acupuncture, massage therapy, chiropractic, or intra-articular injections for the painful knee in the last 3 months. 7. presented with positive neurological signs.
efficacy evaluation of traditional chinese medicine jitai combined comprehensive model among heroin addicts after detoxification

Conditions: Heroin Addiction

Summary: the purpose of this research is to observe the efficacy of comprehensive treatment model to improve treatment compliance and relapse prevention.

the model include the chinese traditional medicine jitai combined with psychological intervention and social support for maintenance therapy after acute detoxification of heroin addicts.on the basis of the existing community management experience and community of professional anti-drug community service，the investigator will adopt the chinese traditional medicine jitai combined with psychological intervention and social support for maintenance therapy after acute detoxification of the community of heroin addicts.the purpose is to observe the comprehensive treatment model to improve treatment compliance and relapse prevention，then the investigator will form a new model of community humane drug treatment.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of the opioid dependence * after detoxification. exclusion criteria： * clinical diagnosis of glaucoma and other severe mental disorder； * serious organic disease within three months； * can not comply with the test requirements； * accept hans therapy instrument； * have tendence of suicide，self-injury and impulse； * ecg abnormalities； * alt or ast greater than 5 times the upper limit of normal； * history of epilepsy； * lactating or pregnant women，or women of childbearing age fails to take effective contraceptive measures； * serious history of drug allergy or known allergy on traditional chinese medicine jitai； * study before the withdrawal less than a half-life of 5.

Keywords: the opioid dependence in rehabilitation phase community
screening for pneumonia: a comparison of ultra low dose chest ct [uld-ct] and conventional chest radiography [cxr]

Conditions: Pneumonia

Summary: the ultrachest study will be a prospective clinical diagnostic performance study with primary objective to establish device diagnostic clinical performance of ultra low dose ct (uld-ct) in order to prove it is more accurate in detecting pneumonia when comparing to standard conventional chest radiography.

* 200 subjects * each subject will undergo cxr and uld-ct at the same day. * subjects subdivided into 3 groups \[high, moderate and low risk\], based on a laboratory finding(crp), symptoms and physical examination. * 3 different thoracic radiologist will judge the scans on existence of consolidation. consolidation will be expressed as binary outcomes (yes or no consolidation) * radiologist will be blinded for subjects demographic data. * all radiologist have to score how confidence they were on the finding of consolidation\[5point likert\]. * the investigators will perform a mcnemar's test for evaluation. a two sided p-value of less than 0.05 will be considered to be statistically significant. * inter-observer variability will be evaluated by using a fleiss kappa test.

Eligibility criteria:
inclusion criteria: * suffering from pneumonia and referred by their gp exclusion criteria: * younger than 18 * known pregnancy * not able to sign the informed consent document * if not willing to be informed about additional findings
the influencing factors and mechanism of high incidence of thrombotic events in patients with mn and dkd

Conditions: Glomerulonephritis, Membranous; Diabetic Nephropathies; Thrombelastography; Thromboembolism

Summary: influence factors and preliminary mechanism of high incidence of thrombotic events in patients with idiopathic membranous nephropathy and diabetes kidney disease

according to the results of renal biopsy, the patients were divided into three groups: membranous nephropathy group (mn), non-membranous nephropathy group (non-mn) and diabetes kidney disease group (dkd). collect the basic data and teg test results of the enrolled patients. (1) ① according to teg results, the enrolled patients were divided into two groups: hypercoagulable group (ci \> 3) and non-hypercoagulable group (ci ≤ 3). the basic data and related laboratory indicators of the two groups were compared - to explore the influencing factors of hypercoagulable (objective x); ② compare the parameters related to teg and coagulation routine between mn group and non-mn group, dkd group and non-mn group respectively - find out the coagulation index (target y) of the difference between groups; ③ build regression models for different target y - explore the influencing factors of grouping variables (mn vs non mn or dkd vs non mn) on y after adjusting other covariates; (2) ① according to whether the patients in the group had thrombotic events or not, all the patients in the group with thrombotic events were divided into mn thrombotic events group and non-mn thrombotic events group according to pathological diagnosis, and the teg, coagulation and other related laboratory results and basic data between the two groups were compared (explore the unique factors and processes that affect the occurrence of thrombotic events in mn group compared with non-mn group); ② according to whether the patients in the mn group who were hospitalized for many times had thrombotic events, the patients were divided into the mn group with thrombotic events and the mn group without thrombotic events. the teg, coagulation and other related laboratory results and basic data between the two groups were compared (to explore the factors and processes that affect the occurrence of thrombotic events in the mn group).

Eligibility criteria:
inclusion criteria: 1. primary glomerular disease patients with renal biopsy results (without hormone or immunosuppressive therapy) and patients with clinical diagnosis of diabetes kidney disease; 2. age 18-70; 3. the liver function is normal. exclusion criteria: 1. other secondary kidney diseases except diabetes; acute renal injury; chronic kidney disease stage 5; 2. there are risk factors of hypercoagulability, such as acute infection, recent trauma, surgery or cancer, pregnancy; 3. anticoagulant and antiplatelet drugs were given within one week; 4. plasma infusion, plasma exchange or hemodialysis within one month; 5. there is a history of thrombotic disease or hemorrhagic disease before renal puncture; 6. participated in other clinical studies within three months.
predictor of postoperative complications after lengthy noncardiac surgery

Conditions: Peripheral Perfusion Index

Summary: many patients undergoing long time surgery will manifest increased level of blood lactate. hyperlactacidemia can cause disturbance of internal environment, then leading to increased complications and longer icu stay, even death. for postoperative patients, we must ensure adequate perfusion in order to minimize the length of hyperglycemia and improve patients' outcomes. with regard to lactate, it provides information about prefusion, but not timely enough for its delay on reflecting hypoperfusion. and it's not real-time and non-invasive. peripheral perfusion index (ppi) is an indicator reflecting hypoperfusion in critical patients. it is measured using pulse co-oximetry technology which is characterized by being real-time and noninvasive. ppi is defined as "the ratio of pulsatile blood flow to the non-pulsatile blood flow", mirroring the strength of blood flow and quality of perfusion at sensor site, reflecting perfusion state of the body part . in contrast to lactate value, it's real-time and easy to monitor.


Eligibility criteria:
* inclusion criteria * adult patients above 18 years of age. * both genders * surgical time planned to be \> 120 minutes . * surgical time predicted to exceed the planned time and prolongation of surgical time \> 120 minutes occured will be included in the study . * asa physical status of i-ii * patients scheduled for elective surgery under general anaesthesia . * exclusion criteria * refused to participate . * patient with disease affecting blood flow to the hands where probe will be applied . * patient with hand injuries so probe cannot be applied * patient with sever renal and liver disease * discharging against medical advice or reported death during icu stay at first 48 hours after icu admission . * pregnancy or emergency surgery . * shortening of the planned surgical time to be less than 120 minutes
visual field restoration in patients with post-stroke homonymous hemianopsia

Conditions: Hemianopsia

Summary: this study will assess the effectiveness of a stimulus, in the blind field of hemianopsic patients, to restore the vision of patients with homonymous hemianopsia consecutive to stroke (unilateral occipital lesion). hemianopsia occurs in 30% of strokes regardless of the cerebral localization and in 60% of stroke interesting the territory of the posterior cerebral artery.


Eligibility criteria:
inclusion criteria: * presence of an homonymous visual field amputation after vascular retrochiasmatic lesion of the occipital region (visual cortex alone or with optical radiations or with other associated occipital areas) * inclusion 3 months to 36 months after stroke * patients aged 18 years and older exclusion criteria: * brain injury history * severe neuropsychological, psychiatric or behavioral disorder * severe eye disorder or visual impairment (visual acuity less than 3/10) * progressive eye disorder (cataracts or glaucoma) * insufficient french language proficiency to understand the questionnaires and rehabilitation tasks * patient under legal protection * patient's opposition to participate in the study * no medical insurance coverage * pregnant pr breastfeeding patient
maintenance chemotherapy in metastatic breast cancer

Conditions: Breast Cancer

Summary: this is a randomized, prospective and multicenter phase iii study. two-hundred-sixty-two (262) patients on each arm will be recruited in the study.

the primary objective is time to disease progression. all patients must be treated with first line chemotherapy, consisting of one of the following regimens: a) et (epirubicin 90 mg/sqm day 1 plus paclitaxel 200 mg/sqm (3 hour infusion) day 1, or b) at (doxorubicin 50 mg/sqm day 1 plus paclitaxel 200 mg/sqm (3 hour infusion) day 2, administered on a 3 weekly schedule. patients with complete response, partial response or stable disease are eligible for manta1 study. the expected median progression free survival of metastatic breast cancer patients who achieve a disease control after first line chemotherapy was estimated to be 10 months. the minimal improvement, justifying the adoption of maintenance paclitaxel, was estimated to be at least 3 months. with 262 eligible patients on each arm, the trial will have a power of 80% to detect a 30% improvement in median progression free survival, testing at the two-sided .05 significance level.

Eligibility criteria:
inclusion criteria: * written informed consent. * patients with metastatic breast cancer in response or stable disease after six to eight courses of first line induction chemotherapy treatment * measurable and/or evaluable disease * performance status ecog 0, 1, 2. * normal cardiac function, confirmed by left ventricular ejection fraction (lvef). exclusion criteria: * presence of peripheral neuropathy \> grade 2 by nci common toxicity criteria (nci-ctc) following induction chemotherapy * adjuvant taxane-based therapy

Keywords: metastatic breast cancer maintenance chemotherapy
collagen alterations in patients with abdominal wall hernias

Conditions: Hernia, Abdominal

Summary: the aim of this study was to evaluate collagen turnover in patients with multiple hernias

venous blood was collected and markers for type iv and v collagen synthesis and breakdown was measured

Eligibility criteria:
inclusion criteria: * patients with a history of three hernia repairs (multiple hernia group) * patients without any history or presence of hernias (control group) exclusion criteria: * connective tissue disorder (ehlers-danloss/marfan) * presence of hernia upon clinical examination (control group)