Kornimate/medical-research-clean huggingface dataset:
carpal bone erosion in rheumatoid arthritis :diagnostic value

Conditions: Rheumatoid Arthritis

Summary: rheumatoid arthritis (ra) is a systemic inflammatory disease characterized by proliferative hyper vascularized synovitis which primarily affects synovial joints. synovium of bursa; tendon sheaths; attachment sites of cartilage, ligament, and tendons to the bone; soft tissue; and bones can be mentioned among the other areas under influence of ra. changes happen to be symmetrical and may present as fusiform soft tissue swelling, regional osteoporosis, marginal-central erosions, cartilage damage, joint destruction, narrowing of joint space and fibrous ankyloses. wrist, metacarpophalangeal and metatarsophalangeal joints are the first sites to be affected .over the past few years, an increasing number of rheumatologists have started to use us in the clinical setting of the early arthritis clinic. while us allows for an accurate and non-invasive multisite assessment of joint involvement in patients with ra, time for us examination is not infinite


Eligibility criteria:
inclusion criteria: * 1. ra patients fulfilled the 2010 american college of rheumatoid arthritis classification criteria.\[8\] 2. sle patients fulfilled the 2019 acr\\eular classification criteria for sle.\[9\] 3. age above 18 years old. 4. patient cooperative and can answer questions. 5. patients who are able and willing to give written informed consent. exclusion criteria: * 1. age below 18 years and above 60 years. 2. uncooperative patients. 3. patient not able and willing to give written informed consent.
evaluation of safety and efficacy of ctx001 in pediatric participants with severe sickle cell disease (scd)

Conditions: Sickle Cell Disease; Hydroxyurea Failure; Hydroxyurea Intolerance; Hemoglobinopathies; Hematological Diseases

Summary: this is a single-dose, open-label study in pediatric participants with severe scd and hydroxyurea (hu) failure or intolerance. the study will evaluate the safety and efficacy of autologous crispr-cas9 modified cd34+ human hematopoietic stem and progenitor cells (hhspcs) (ctx001).


Eligibility criteria:
key inclusion criteria: * diagnosis of severe scd as defined by: * documented scd genotypes * history of at least two severe vocs events per year for the previous two years prior to enrollment * hydroxyurea (hu) failure unless hu intolerant * eligible for autologous stem cell transplant as per investigators judgment key exclusion criteria: * a willing and healthy 10/10 human leukocyte antigen (hla)-matched related donor * prior hematopoietic stem cell transplant (hsct). * clinically significant and active bacterial, viral, fungal, or parasitic infection other protocol defined inclusion/exclusion criteria may apply.
evaluation of the scalpelcric set and comparison with two further techniques of cricothyrotomy

Conditions: Cricothyroidotomy

Summary: during a cannot ventilate cannot intubate situation surgical airway is the last rescue option. especially in the prehospital setting the airway management seems to be more difficult than in a hospital setting. nearly all emergency physicians have a limited experience with cricothyrotomy and it is a unclear what method should be taught for this lifesaving procedure, due to lack of data in humans. the aim of this study is to compare the performance of medical personnel (medical students, paramedics, trainee anaesthetists and consultants) in establishing an emergency surgical airway on a plastic laryngeal model and in a porcine laryngeal model using the scalpel bougie technique, the seldinger technique and the common surgical technique. furthermore the investigators want to elucidate whether the training of the 3 techniques has an influence in the decision making of the preferred technique in a subsequently simulated cannot ventilate cannot intubate scenario.

the investigators plan to recruit medical students (university mainz), paramedics (employed in ambulance and rescue helicopter), trainee anaesthetists and consultants of the department of anesthesiology from the university hospital mainz. after written informed consent the participants have to complete an pre-study questionnaire, than the participants get an information sheet about the 3 techniques and the investigators show the participants a short video demonstrating the different techniques. all participants have the opportunity to practice one insertion with each method on a plastic laryngeal model. after that the participants have to perform each technique on the plastic model and the investigators measure the time from initially handling equipment to the final end-point, which the investigators take as a successful placement of the endotracheal tube verified by a fiberoptic position check.

Eligibility criteria:
inclusion criteria: * written informed consent * german language in speaking and writing * capability of giving consent exclusion criteria: * participants unwilling or unable to give informed consent

Keywords: cvci emergency medicine airway management cricothyroidotomy
effects of nicotinic acid plus simvastatin versus simvastatin alone on carotid and femoral intima-media thickness in patients with peripheral artery disease (nascit)

Conditions: Dyslipidemia; Atherosclerosis

Summary: dyslipidaemia is characterized by low plasma levels of high-density lipoprotein cholesterol (hdl-c), elevated triglycerides and an increase in low density lipoprotein (ldl-c) particles, and has been unequivocally established as a most important cardiovascular risk factor. while statins are effective in reducing plasma levels of ldl-c, these drugs have only modest effects on raising hdl-c (typically by less than 10%), even with aggressive statin therapy. however, increasing evidence suggests that low hdl-c might be at least as relevant as high ldl-c in promoting the development and progression of atherosclerosis. the beneficial effect of raising hdl-c on clinical outcome has already been demonstrated by several studies. nicotinic acid is the most potent agent available for raising plasma levels of hdl-c by up to 29% at clinically recommended doses, and substantially lowers triglycerides and ldl-c. furthermore, nicotinic acid is also the most potent lipid lowering agent available that reduces lp(a), an independent marker of cardiovascular risk. in a recent study patients with coronary artery disease had a 21% increase in hdl-c and a 13% decrease in triglycerides, and these beneficial effects on lipid status may have contributed to a stabilization or regression of carotid intima-media-thickness (imt).the impact in patients with advanced atherosclerosis like peripheral artery disease (pad) in unknown. the investigators hypothesized that nicotinic acid in addition to statin therapy may inhibit progression of peripheral arterial atherosclerosis. therefore, the aim of the present randomized controlled trial is to investigate the effects of nicotinic acid (daily dose starting with 500 mg, up to 2000mg) in addition to simvastatin (40 mg daily) versus simvastatin (40mg daily) monotherapy in patients with low serum hdl-c levels and pad with respect to changes of carotid and femoral imt, changes of patients´ lipid status and occurrence of major adverse cardiovascular events (mace).


Eligibility criteria:
inclusion criteria: * pad defined as an abi ≤0.9 or \>1.3 in patients with low serum hdl cholesterol levels (\<45mg/dl in men, \<55 mg/dl in women) exclusion criteria: * elevated liver enzymes (above 2 times the normal level) * skeletal muscle myopathy or elevated serum ck levels * allergy or hypersensibility to either statins or nicotinic acid * women of childbearing potential

Keywords: intima-media-thickness dyslipidemia progression of atherosclerosis peripheral artery disease major cardiovascular events
haic plus h101 vs haic alone for unresectable hcc at bclc a-b

Conditions: Hepatocellular Carcinoma

Summary: hepatic artery infusion chemotherapy (haic) is effective and safe for hepatocellular carcinoma (hcc). recombinant human type-5 adenovirus (h101) is safe for hcc. the purpose of this study is to evaluate the efficacy and safety of haic combined with h101 compared with haic alone in patients with unresectable hepatocellular carcinoma (hcc) at barcelona clinic liver cancer a-b stage.


Eligibility criteria:
inclusion criteria: * the diagnosis of hcc * patients must have at least one tumor lesion that can be accurately measured according to mrecist criteria. * with no previous treatment * single lesion with tumor size larger 7cm or multiple lesions * no cirrhosis or cirrhotic status of child-pugh class a only * not amendable to surgical resection ,local ablative therapy and any other cured treatment. * bclc a-b stage * the following laboratory parameters: platelet count ≥ 50,000/μl hemoglobin ≥ 8.5 g/dl total bilirubin ≤ 30mmol/l serum albumin ≥ 32 g/l asl and ast ≤ 6 x upper limit of normal serum creatinine ≤ 1.5 x upper limit of normal inr ≤ 1.5 or pt/aptt within normal limits absolute neutrophil count (anc) \>1,500/mm3 exclusion criteria: * patients complicated by history of heart disease, history of gastrointestinal bleeding within 1 month, severe infection (\> grade 2 national cancer institute \[nci\] -common terminology criteria for adverse events \[ctcae\] version 4.0) or other serious associated diseases will not be able to tolerate treatment * with other malignant tumors * known or suspected allergy to the investigational agents or any agent given in association with this trial * history of organ allograft * pregnant or lactating woman * patients with poor compliance

Keywords: hepatocellular carcinoma hepatic artery infusion chemotherapy oxaliplatin, 5-fluorouracil and leucovorin recombinant human type-5 adenovirus
safety and tolerability of oxc xr as adjunctive therapy in subjects with refractory partial epilepsy

Conditions: Partial Epilepsy

Summary: open-label extension study to evaluate the long-term safety and tolerability of oxcarbazepine extended-release (oxc xr)

nap

Eligibility criteria:
inclusion criteria 1. able to provide written informed consent and agree to comply with study procedures. 2. male or female aged 18 to 66 years, inclusive. 3. successful completion of the 804p301 study. 4. sexually active women, unless surgically sterile (at least 6 months prior to study medication \[sm\] administration) or at least 1 year post-menopausal, must use an effective method of avoiding pregnancy (including oral, transdermal, or implanted contraceptives \[any hormonal method in conjunction with a secondary method\], intrauterine device, female condom with spermicide, diaphragm with spermicide, cervical cap, abstinence, use of condom with spermicide by sexual partner or sterile \[at least 6 months prior to sm administration\] sexual partner) for at least four weeks prior to sm administration, and must agree to continue using such precautions through the end of study visit. cessation of birth control after this point should be discussed with a responsible physician. exclusion criteria 1. clinically significant change in health status that, in the opinion of the investigator, would prevent the subject from participating in this study or successfully completing this study. 2. any reason which, in the opinion of the investigator, would prevent the subject from participating in the study.
plaqenil role in prevention of age related macular degeneration

Conditions: Age Related Macular Degeneration

Summary: the investigators think that there is a connection between the use of plaquenil and the prevention of age related macular degeneration (amd). the investigators believe that the use of plaquenil makes bruch's membrane thicker, thereby preventing chroidal neovascularization (cnv) growth.

the study is done by comparing to groups ra patients who take plaquenil vs. group of patients who do not take plaquenil. after measuring the retina thickness we compare the avg. thickness of both groups.

Eligibility criteria:
inclusion criteria: * all people who suffer from rheumatoid arthritis (ra) and use plaquenil exclusion criteria: * patients who did not complete follow-up

Keywords: amd plaquenil cnv
trial of cp-751, 871 and erlotinib in refractory lung cancer

Conditions: Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carcinoma, Adenosquamous Cell

Summary: the objective of this study is to test a clinical benefit of the addition of cp 751,871 to erlotinib therapy in patients with advanced nsclc of non adenocarcinoma histology. the primary endpoint is overall survival (os).

this study was terminated on march 8, 2010 due to an analysis by an independent data safety monitoring committee (dsmc) indicating that the addition of cp-751,871 \[figitumumab\] to erlotinib \[tarceva\] would be unlikely to meet the primary endpoint of improving overall survival when compared to erlotinib alone. this oncology study continues as terminated, however for ethical reasons some patients, noted with resultant benefit, continue receiving treatment.

Eligibility criteria:
inclusion criteria: * non small cell lung cancer with a primary histology of squamous cell, large cell or adenosquamous carcinoma. at least 1 measurable lesion, as defined by recist. exclusion criteria: * primary nsclc adenocarcinoma and its subtypes or unknown/unspecified histology. * prior erlotinib therapy. * prior anti igf ir based investigational therapy.

Keywords: igr-1r non small cell lung cancer cp-751 871 figitumumab
acute combined care for seniors in southern denmark

Conditions: Acute Medical Conditions

Summary: the elderly population (+ 65 years) is increasing. acute medical conditions often leads to hospital admissions in this age group. however hospital admission is linked to adverse events. like confusion, medication errors or new infections. the access project aims to examine alternatives to acute admissions for senior medical patients. the aims are: 1. how many patients will be admitted to hospital due to acute medical conditions if cared for by their own general practitioner (gp) versus a hospital intern specialist ? 2. how many patients will be admitted to hospital due to acute medical conditions if cared for by acute team in their home versus in specialised care centres ?


Eligibility criteria:
inclusion criteria: * acute medical condition requiring immediate intervention. exclusion criteria: * gp not available next days * absolutely admission requiring condition * no informed consent obtainable * nursing home resident * inclusion in access within the last 3 months * home care capacity limit reached

Keywords: patient admission
w-shaped acetabular angular plate (waap) versus reconstruction plate

Conditions: Fracture of Posterior Wall of Acetabulum

Summary: the purpose of this study is to determine whether this new w-shaped angular plate is more effective and more safe to operate than the traditional reconstruction plate in the treatment of the posterior wall fracture of acetabulum.

the posterior acetabular wall fracture is one of the simpler acetabular fracture patterns and the most common type, accounting for approximately one quarter of all acetabular fractures. most patients achieve excellent outcomes after anatomical reduction and rigid internal fixation with standard screws and buttress plates.however,it is well known that the reconstruction plate need remould in the surgery. so it does not only lead to the extension of operation time, but also cause poor attach of acetabular posterior wall. moreover, the angulation of the screw placement for the holes of the reconstruction plate in the danger zone was determined with only caution. the intraoperative fluoroscopy was employed frequently to help determine the periacetabular screw location. if the operator lack of experience, intraarticular screw penetration and prolonged operative duration is inevitable. the investigators now introduce a new type of internal fixation device of acetabular posterior wall fracture that improve the shortcomings of existing technology.the plate itself can be thought to consist of three regions: the iliac region, the danger zone region, and the ischial tuberosity region. the organization of these regions causes the plate to resemble the english alphabet letter ''w''.the contour and zygomorphy of the w-shaped plate matched the surface of the posterior column of the acetabulum. there are two rows of drill holes in the danger zone region. a special safe-angled drilling guide was used to assist in the operation. a retrospective study has been indicated that this kind of new plate produce good results. this device may help to avoid intraarticular screw penetration and reduce operative duration and blood loss. the device further provides a stable fixation of the posterior wall that is amenable to early range of motion and weight bearing postoperatively, and results in a good clinical outcome.

Eligibility criteria:
inclusion criteria: * male or female aged 18 years or older(with no upper age limit) * sustained a posterior acetabular wall fracture(asif/ota classification 62-a1) * operation was performed within 14 days after the fracture occurring exclusion criteria: * presented with a pathologic acetabular fracture * neuropathic arthropathy,dementia and other disease processes which made postoperative compliance unreliable * refused to participate * patients who were unable to walk before injury
adaptive arm training for children with hemiplegia

Conditions: Cerebral Palsy; Hemiplegia; Hemiparesis; Acquired Brain Injury

Summary: the goal of this research is to provide limb training in children with hemiplegia using a bimanual-to-unimanual training approach. twenty pediatric patients aged 5-17 years with acquired brain injury will receive training on the bimanual-to-unimanual device for a period of 9 weeks. during the training, children use both arms to operate robotic arms to play a video game. we will assess changes in hand impairment after the training.


Eligibility criteria:
inclusion criteria: * hemiplegia due to brain injury at least 3 months before study enrollment. exclusion criteria: * any social or medical problem that precludes compliance with the protocol. * treatment with botulinum toxin or intrathecal baclofen in the 3 months preceding enrollment. * implanted neuromodulatory or electronic device or other complicating illness.
validity of bispectral index monitoring during deep sedation

Conditions: Cerebral Palsy

Summary: during intramuscular botulinum toxin injections for children with cerebral palsy, immobility is essential to inject botulinum toxin to the right muscle. because children with cerebral palsy are generally unable to control their movement, deep sedation is required during this painful procedure. short-acting drugs such as propofol and remifentanil are widely used for pediatric anesthesia and sedation but still have possibility of over-sedation and associated complications due to their rather narrow therapeutic window. therefore, objective scoring system to assess the level of sedation to provide an effective and safe sedation in children. bispectral index (bis) monitoring,an objective guidance of sedation might be helpful. the present study is to investigate the validity of the bis monitoring during deep sedation of children with cerebral palsy for injection of botulinum toxin.

intramuscular botulinum toxin injections for children with cerebral palsy have been extensively performed to relive spasticity and improve rehabilitation. during procedure immobility is essential to inject botulinum toxin to the right muscle for optimal effect. because children with cerebral palsy are generally unable to control their movement, deep sedation is required during this painful procedure. short-acting drugs with rapid, predictable onset and offset of action, such as propofol and remifentanil, facilitate infusion rate adjustments and rapid recovery. however, there is always the possibility of over-sedation, hypotension and respiratory depression due to their rather narrow therapeutic window. several clinical sedation scales have been used to provide an effective and safe sedation in children. because clinical scoring depends on patient response to verbal or physical stimulation, it is difficult to assess the level of sedatin in patients with deep sedation during delicate phase of the procedure. bispectral index (bis) monitoring,an objective guidance of sedation might be helpful. although bis scores in children with conscious and deep sedation were reported to correlate with clinical sedation scales, the validity during painful procedure in children with cerebral palsy was not investigated yet. the present study is to investigate the validity of the bis monitoring and its correlation to university of michigan sedation scale during deep sedation of children with cerebral palsy for injection of botulinum toxin.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status i-ii healthy children ages eligible for study: 3 to 18 years scheduled for injection of botulinum toxin under deep sedation exclusion criteria: * unstable cardiac disease recent (\< 8 week) pneumonia, bronchitis, asthma attack, respiratory infection craniofacial defect history of a difficult airway management hypotonia and lack of head control tremors

Keywords: cerebral palsy botulinum toxin propofol deep sedation bispectral index monitor
clinical trial to examine individual pain tolerance in the use of two anesthetic techniques to perform saturation prostate biopsy

Conditions: Prostatic Cancer

Summary: to assess the effectiveness of two anesthetic techniques by measuring the pain through visual analog scale (vas), to obtain saturation prostate biopsies.

to assess the effectiveness of two anesthetic techniques by measuring the pain through visual analog scale (vas), to obtain saturation prostate biopsies. anesthetic technique (control) - intravenous sedation with midazolam, fentanile and ketamine. anesthetic technique (intervention) - regional mepivacaine infiltration of periprostatic region.

Eligibility criteria:
inclusion criteria: * male patient * persistence of suspected prostate cancer by altering the prostatic specific antigen and / or digital rectal examination. * two previous negative prostate biopsies . * age \< 75 years. * signature of informed consent to perform prostate biopsy. * signature of informed consent for the study. exclusion criteria: * age \> 75 years. * absence of consent or refusal to the study . * presence of prostate cancer in previous biopsy observation . * medical-surgical patient's problems, absolutely contraindicating biopsy under local anesthesia. * presence of any allergies to medications involved in the study . * patient's clinical situation that does not allow an outpatient operation and aftercare required . * medical condition of the patient, preventing the realization of outpatient biopsy. * no companion.

Keywords: prostate biopsy local anesthesia pain biopsy of prostate