Kornimate/medical-research-clean huggingface dataset:
ergonomic benefits from robotically assisted laparoscopy for hysterectomies and other indications

Conditions: Musculoskeletal Diseases or Conditions

Summary: this is a prospective, single-center, observational clinical trial at the department of women's health of the university hospital tübingen.

monocentric trial to evaluate differences in musculoskeletal and cognitive demands of robot-assisted laparoscopic surgery (rals) vs. conventional laparoscopic surgery (cls). demographic and personal data are collected and pseudonymized. during surgery surface electromyography (emg), electrocardiography (ecg), motion tracking data are collected and the surgery is documented by photos (1 photo/per second). additionally, perceived physical discomfort (frequency and intensity) and mental load will be assessed within certain time intervals and at the very end of the surgery. the surgeon will not be disturbed in his actions and movement by the measurement equipment or applied procedures. previous studies with similar designs can be seen as references in this context (549/2012bo1, 409/2013bo1, 262/2018bo1). after completing the surgery, the surgeon will rate difficulty of the surgery, work precision, eye strain and ergonomics during the surgery. routine interventions like hysterectomies and other selected indications will be analyzed.

Eligibility criteria:
inclusion criteria: * age between 18 and 68 years * surgeons that are able to work in full shift * trained surgeons in rals and cls * written informed consent exclusion criteria: * persons influenced by analgesics or muscle relaxants * persons not able to perform their common work for any reason * persons with acute diseases * muscle injury

Keywords: muscular and mental demand physical discomfort eye strain
thoracoscopic vascular rings chart review

Conditions: Cardiovascular Abnormalities

Summary: the purpose of this study is to review the use of diverticulopexy, and collect data regarding the ease of the procedure and the overall outcome.

in addition to dividing the vascular ring, some surgeons stress the importance of performing a diverticulopexy (an additional stitch which holds the ring open and prevents recurrence). this is a difficult step to perform through the thoracoscope. we plan to review the use of this step, the diverticulopexy, and collect data regarding the ease of the procedure and the overall outcome. once we have accomplished this, we hope to present our initial results of this new procedure.

Eligibility criteria:
inclusion criteria: * all patients undergoing vascular ring division at children's healthcare of atlanta at egleston hospital between 2001 and 2004

Keywords: children's healthcare of atlanta pediatric thoracoscopic vascular ring diverticulopexy vascular ring division
effectiveness of exercise given with ergonomics training in tea workers

Conditions: Neck Pain; Back Pain; Work-related Illness

Summary: the aim of our study is to investigate the effectiveness of exercise against work-related musculoskeletal disorders in tea workers.

individuals who volunteer to participate in the study will be evaluated considering the inclusion and exclusion criteria, and participants will participate in the study after reading and signing the informed consent form. tea workers who collect tea will be divided into 2 groups. .demographic information form, visual analogue scale (vas), upper extremity discomfort analysis, rapid upper extremity assessment (rula), sleep quality, scandinavian musculoskeletal system questionnaire will be given to the participants of both groups. the surveys will be carried out face to face. after the application of the surveys, statistical data will be obtained. analyzes will be made. one group will be given exercise, the other group will not be given exercise. post-exercise surveys will be conducted again to check the effectiveness of the exercise.

Eligibility criteria:
inclusion criteria * being between the ages of 25-45. * having been a tea craftsman for at least 10 years. * having the ability to read and write turkish. * agreeing to participate in the study voluntarily. exclusion criteria * being diagnosed with a serious psychological illness. * malignancy * advanced osteoporosis * being under 25 years of age.
the effects of pilates-based core stabilization training in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: multiple sclerosis (ms) is a chronic, autoimmune and neurodegenerative disease characterized by inflammation and progressive demyelination of the central nervous system. it is characterized by muscle weakness, balance and coordination disorder, which is more common in the lower extremities and trunk muscles. over time, these symptoms decrease the individual's level of physical activity, mobility and quality of life, leading to further deterioration of the disorder. one of the most important problems that cause these problems in individuals with ms is reduced core stabilization. decrease in core stabilization affects the quality of limb movements as well as trunk stability when considering the kinetic chain in the body. pilates-based core stabilization training (pbcst) are a controlled exercise form used to improve the stabilization of trunk muscles. there are no studies on the effect of this training on lower extremity isokinetic muscle strength in individuals with ms. the aim of this study is to determine the effect of pbcst on lower extremity muscle strength, postural sway and kinetic chain in individuals with ms.

the study was planned as randomized controlled. individuals included in the study wiil randomly allocate to the group receiving the supervised pbcst and the home exercise group. while the supervised exercise group receives pbcst for 2 days and 8 weeks in the clinic, the home exercise group will perform the same exercises at home for the same time as the brochures prepared for them. the exercise program will show progression at 2-week intervals. a session will be held for both groups to teach the basic principles of pilates and will not be counted in the 8-week program. at the beginning and end of treatment, individuals will be evaluated for isokinetic muscle strength, balance and postural sway, fatigue level, quality of life and functional capacity parameters. pbcst is thought to reduce postural sways and increase lower extremity muscle strength by increasing core stability with the effect of kinetic chain and increased stabilization.

Eligibility criteria:
inclusion criteria: * being diagnosed with ms according to mcdonald's criteria * disability level less than 6 according to edss (expanded disability status scale) score * no attacks during the last 3 months * being an ambulatory * volunteering to participate in the study exclusion criteria: * having orthopedic, neurological, psychological, etc. diseases that accompany ms and may affect treatment outcomes * doing regular sports * being involved in another physiotherapy and rehabilitation program related to ms

Keywords: multiple sclerosis pilates core stability isokinetic strength postural sway
a study of pf-06410293 (adalimumab-pfizer) and adalimumab (humira®) in combination with methotrexate in subjects with active rheumatoid arthritis (reflections b538-02).

Conditions: Rheumatoid Arthritis

Summary: the study will assess the efficacy, safety, and immunogenicity of pf-06410293 and adalimumab in combination with methotrexate in subjects with moderately to severly active rheumatoid arthritis who have had an inadequate response to methotrexate. in an additional optional portion of the study, during open label treatment period 3 (tp3), a subset of subjects used a prefilled pen (pfp) to administer up to 3 injections of their study treatment (pf-06410293) at home.


Eligibility criteria:
inclusion criteria: * diagnosis of rheumatoid arthritis based on 2010 acr/eular criteria for at least 4 months. * at least 6 tender (of 68 assessed) and 6 swollen (of 66 assessed) joints at screening and baseline. * hs-crp equal or greater than 8 mg/l. * must have received methotrexate for at least 12 weeks and been on a stable dose for at least 4 weeks prior to the first study dose. exclusion criteria: * evidence of untreated or inadequately treated latent or active tb. * evidence of uncontrolled, clinically significant diseases, including moderate or severe heart failure (nyha class iii/iv) or malignancy in the previous 5 years. * history of infection requiring hospitalization or parenteral antimicrobial therapy within 6 months prior to first dose of study drug. * may have received no more than 2 doses of one biologic therapy (other than adalimumab or lymphocyte depleting therapy). * any second dmard must be washed out prior to the first study dose.

Keywords: phase 3 adalimumab rheumatoid arthritis
endoscopic guided pcnl versus standard pcnl

Conditions: Stones, Kidney

Summary: currently, percutaneous nephrolithotomy (pcnl) is the standard procedure of choice for management of large renal more than 2 cm. the pivotal step in performing pcnl is creation of proper tract. this step can be done monitored under guidance of different modalities such as fluoroscopy, ultrasonography, endoscopy or combined in ecirs, tract creation is controlled under endoscopic vision with a flexible ureteroscope .

aim: compare safety and efficacy and adverse events of ecirs in comparison of standard fluoroscopic guided pcnl. patients \& methods: patients will randomly be divided into two equal groups: group a: patient will undergo ecirs. group b: patient will undergo standard pcnl

Eligibility criteria:
inclusion criteria: * patients with renal stones diameter of at least 2 cm. * american society of anesthesiology score ≤ 2. exclusion criteria: * patients with renal anomalies. * transplanted kidney. * uncorrected coagulopathy. * active infection.
associations between pain perceptions and movement-evoked pain.

Conditions: Musculoskeletal Pain

Summary: the aim of this study is to investigate the associations between pain cognitions and movement-evoked pain in people with musculoskeletal pain complaints.

this study will investigate the associations between pain cognitions and movement-evoked pain in people with musculoskeletal pain complaints. this study will be carried out as a cross-sectional study. participants will be recruited by means of flyers and social media. pain cognitions will be assessed using questionnaires (the pain catastrophizing scale (pcs), the llness perception questionnaire-revised (ipq-r), the pain vigilance and awareness questionnaire (pvaq), the tampa scale for kinesiophobia (tsk), the 36-item short form health survey (sf-36)), whilst movement-evoked pain will be assessed using a lifting task. participants will need to rate the experienced pain immediately after completing the task. to estimate the extent to which pain cognitions explain movement-evoked pain, correlational analyses will first be conducted between all variables to determine what variables will be included in the hierarchical regression analysis.

Eligibility criteria:
inclusion criteria: * 18 years or older, * presence of musculoskeletal pain for more than three months, * medically stable (no serious health conditions, no pending surgery or invasive medical procedure, no contraindication to physical activity). exclusion criteria: * presence of co-existing pain conditions of other origins with chronic musculoskeletal pain not being the primary condition (i.e. predominant subject of symptom complaints) * severe underlying comorbidity (like diagnosed diabetes, cardiovascular problems, etc.) * pregnant or given birth in the preceding year.
the impact of coronary chronic total occlusion percutaneous coronary intervention on culprit vessel physiology

Conditions: Chronic Total Occlusion of Coronary Artery

Summary: following successful cto pci, a multitude of physiological and anatomical changes take place. contemporary techniques such as dissection/re-entry or lumen-lumen wiring may influence the immediate and longer term follow up of these features. it is not known whether changes in this level of physiology and anatomy in the context of cto vessels correlate with each other, or with quality of life and exercise capacity. this study aims to take physiological measurements of absolute coronary flow, resistance and pressure and intra-coronary imaging immediately after successful cto pci. the investigators will relate these to each other and to the method of revascularisation, comparing changes in these groups at three months follow up. qol measurements, and exercise testing will be carried out to see if there is a relationship between physiological and anatomical changes with exercise capacity and quality of life. results from this study could shed light on optimisation of cto pci procedural and clinical outcomes.

following successful chronic total occlusion (cto) percutaneous coronary intervention (pci), a multitude of physiological and anatomical changes take place. contemporary techniques such as dissection/re-entry or lumen-lumen wiring may influence the immediate and longer term follow up of these features. it is not known whether changes in this level of physiology and anatomy in the context of cto vessels correlate with each other, or with quality of life and exercise capacity. this study aims to take physiological measurements of absolute coronary flow, resistance and pressure and intra-coronary imaging immediately after successful cto pci. the investigators will relate these to each other and to the method of revascularisation, comparing changes in these groups at three months follow up. quality of life measurements, and exercise testing will be carried out to see if there is a relationship between physiological and anatomical changes with exercise capacity and quality of life. results from this study could shed light on optimisation of cto pci procedural and clinical outcomes.

Eligibility criteria:
inclusion criteria: * 18 years of age * presence of a coronary chronic total occlusion (cto) scheduled for elective percutaneous coronary angioplasty (pci) * evidence of viability in the cto territory exclusion criteria: * \< 18 year of age * unable to give informed consent * known severe chronic kidney disease (creatinine clearance ≤30 ml/min), unless the patient is on dialysis * unable to receive antiplatelets or periprocedural anticoagulation * contraindications to adenosine * any study lesion characteristic resulting in the expected inability to deliver fd-oct catheter at the distal vessel post cto pci (e.g. moderate or severe vessel calcification or tortuosity) * pregnancy, planning pregnancy during study period, or breastfeeding

Keywords: cto - chronic total occlusion oct - optical coherence tomography coronary physiology absolute flow
unprepped ct colonography

Conditions: Colorectal Neoplasms

Summary: it is our objective to improve the performance of ctc in the prepared colon, and to validate ctc in the unprepared colon for the detection of colorectal neoplasia. the cost-effectiveness ratio of ctc in the unprepared colon will compare favorably with other colorectal screening test.

to improve the diagnostic performance of ctc in the prepared colon using improved spatial resolution, advanced image displays, and computer-assisted diagnosis, and to optimize diagnostic performance of ctc in the unprepared colon for colorectal polyp detection using electronic stool subtraction and computer-aided diagnostic techniques. to estimate the sensitivity and specificity of ctc in the unprepared colon for clinically important colorectal neoplasms (large adenomas ≥ 1 cm) and to compare such estimates with colonoscopy. to survey patient acceptance of ctc in the unprepared colon, and to assess implications for health care costs and cost-effectiveness of ctc in the unprepared colon in comparison with other approaches.

Eligibility criteria:
inclusion criteria: average risk or higher for colorectal cancer and scheduled for colonoscopy with any of the following indications: * prior colorectal cancer, prior colorectal adenoma, strong family history of colorectal neoplasia, iron deficiency. * age ≥ 40 -100 years * known or highly suspected primary colorectal neoplasms \> 10 mm (n = 160) * higher than average risk for colorectal cancer and scheduled for colonoscopy with any of the following indications: prior colorectal cancer, prior colorectal adenoma, strong family history of colorectal neoplasia, iron deficiency. exclusion criteria: * less than 1/2 of colorectum remaining * inflammatory bowel disease (crohns, chronic ulcerative colitis) * familial polyposis * melena, hematochezia

Keywords: colonic polyps colon large intestine cecum sigmoid rectum colonoscopy virtual colonoscopy ct colonography computed tomographic colonography colonography
trazodone for sleep disturbance in early alcohol recovery

Conditions: Alcoholism

Summary: this study is a randomized, double-blind clinical trial comparing trazodone (desyrel) and placebo among sleep-disturbed, alcohol-dependent individuals shortly after discharge from an inpatient detoxification program. subjects will undergo a baseline assessment and random assignment to trazodone or identical placebo for 12 weeks. all persons completing the alcohol detoxification at stanley street treatment and resources (sstar) will be screened. (sstar of rhode island provides detoxification services to non/underinsured persons of rhode island.)


Eligibility criteria:
inclusion criteria: * completed an alcohol detoxification program. * meets criteria for alcohol dependence. * meets criteria for sleep disturbance. * if female of childbearing potential must be using adequate contraception. * has a location to which they will return after the initial research interview and a person they regularly contact. * speaks english sufficiently to understand instructions and assessment. exclusion criteria: * meets criteria for substance dependence for sedative/hypnotic drugs, stimulants, cocaine or opiates, or of organic brain disorder, bipolar disorder, schizophrenia, schizoaffective, schizophreniform, or paranoid disorder, or major depression. * current suicidality. * use of psychotropic, antidepressant, anxiolytic or antidipsogenic medication. * inability or refusal to terminate the use of proerectile agents, herbal medications or sleep medication for the study period. * the presence of contraindications to the study medications, including pregnancy/lactation, ischemic heart disease, cardiac arrhythmias, priapism or hypotension. * presence of comorbid medical conditions associated with sleep disturbance including obstructive sleep apnea, poorly controlled diabetes mellitus or emphysema. * evidence of neuropsychological dysfunction. * probation/parole requirements that might interfere with participation in study. * inability to identify at least one contact person. * living on the street after detoxification (homeless persons living in a shelter, halfway house or other residence will not be excluded).

Keywords: alcoholism alcohol dependence trazadone sleep
palatal mucosa wound healing following antimicrobial gel application

Conditions: Wound Healing; Palate; Wound; Hyaluronic Acid

Summary: the present study will be a prospective, randomized, triple-blind, split-mouth, clinical trial. the study timeline will be include seven total visits. after a screening/study enrolment visit, a wounding surgery visit (day 0) will be schedule. on day 0, one standardized wound will be created on each side of the palate (dfgg required for root coverage procedure). each side of the palate randomly received either antimicrobial gel (treatment group) or placebo (control group) at day 0, 1 and 3. the patients, an experienced periodontist who performed the surgical procedures and the clinical examiners will be blinded to treatment allocation. clinical healing response and patient related outcome measures (proms) will be evaluated on postoperative day 1, 3, 7, 14, 21 and 30.


Eligibility criteria:
inclusion criteria: * aged 18 to 38 years (age limits based on evidence of delayed wound healing in older adults, engeland et al., 2006); * full-mouth plaque score and full-mouth bleeding score ≤ 15% at study entry; * adequate anteroposterior arch length for required wound size and spacing; * able to easily tolerate maxillary impression making and use of palatal template; * patients required at least two root coverages procedures in one tooth in different sextants with dfgg; * palate with no pathological or morphological alteration. exclusion criteria: * untreated periodontitis; * previous surgery on the palate; * history of poor wound healing; * systemic diseases and/or coagulations disorders; * pregnant or lactating; * smoking or marijuana use (non-smoker status verified by exhaled air carbon monoxide as previously described); * medications affecting periodontal status (e.g. phenytoin, calcium channel blockers and cyclosporine); * therapy with anticoagulants, nonsteroidal anti-inflammatory drugs, corticosteroids, or any drug interfering with the healing process during the previous six months; * contraindication to receiving any of the active components of the antimicrobial gel.

Keywords: wound healing palatal mucosa hyaluronic acid lactoferrin postbiotics aloe
mechanochemical ablation compared to cyanoacrylate adhesive

Conditions: Varicose Veins

Summary: this study will be comparing the treatment of varicose veins using either mechanochemical ablation (moca) or cyanoacrylate adhesive (cae). patients will be randomised to receiving either moca or cae. the pain scores, clinical scores, quality of life scores, occlusion and re-intervention rate at 2 weeks, 3, 6 and 12 months as well as the cost effectiveness of each intervention will be assessed.

this will be a randomised clinical trial comparing moca to cae. patients will be randomised into group a (moca) or group b (cae). only the endovenous ablation part of the procedure will be randomised while the decision as to whether patients should receive treatment of their varicose tributaries will be at the discretion of the clinical team. the device used for moca (group a) will be the clarivein® mechanochemical ablation (moca) device (vascular insights, madison, ct, usa). the device used for cae (group b) will be the venasealtm closure system (medtronic, minneapolis, minnesota, usa). re-intervention of the treated saphenous veins will not be decided until at least 3 months after their initial procedure.

Eligibility criteria:
inclusion criteria: * adults over 18 years of age * symptomatic gsv or ssv vein reflux \> 0.5 seconds on colour duplex exclusion criteria: * current dvt * recurrent varicose veins * arterial disease (abpi\<0.8) * vein diameter \< 3mm * patient who are unwilling to participate * inability or unwillingness to complete questionnaires * adverse reaction to sclerosant or cyanoacrylate * not been involved in another venous trial for at least 6 months
post-marketing safety surveillance of qizhi tongluo capsules:a registry study.

Conditions: Safety Surveillance; Adverse Drug Events; Adverse Drug Reactions; Severe Adverse Events; Severe Adverse Reactions

Summary: this registry aims to monitor the safety of qizhi tongluo capsules and to identify the potential risk factors for its adverse drug reactions.


Eligibility criteria:
inclusion criteria: * patients who use qizhi tongluo capsules in the monitoring hospitals. exclusion criteria: * none