Kornimate/medical-research-clean huggingface dataset:
somatic symptom and related disorders: a treatment group and mixed-methods investigation

Conditions: Somatic Symptom Disorders

Summary: the purpose of this study is to evaluate the effectiveness of a new cognitive behavioural therapy (cbt) group for individuals with a somatic symptom disorder (i.e., somatic symptom and related disorders from the dsm-5). patients with somatic symptom and related disorders are underserved by the medical system. further, there is currently a paucity of research aimed at evaluating treatments for patients with somatic symptom disorders. the limited existing research literature supports cbt as an efficacious treatment in this population, but a standardized means of modifying cbt for somatic symptom disorders has not been developed, and it is unclear if group cbt is effective. in this study, the investigators will evaluate the effectives of a new six session cbt group designed specifically to address commonly-reported difficulties among individuals with somatic symptom disorders, such as somatic symptoms, psychological distress, and related cognitive interference. this study will allow us to validate a new intervention for somatic symptom disorders, and will help to fill the current void of evidence-supported evaluation and treatment protocols to better serve patients with somatic symptom disorders.


Eligibility criteria:
inclusion criteria: 1. 18 years or older, 2. formally diagnosed with a somatic symptom or related disorder, 3. registered patients of st. joseph's healthcare hamilton, and 4. subjective psychological complaints and somatic complaints causing distress and/or functional impairment. exclusion criteria: individuals with 1. acute and severe depression/suicidal ideation, 2. severe ptsd symptoms, 3. current psychosis, 4. current substance use disorder, or 5. severe cognitive impairment will be excluded from the study and referred to a more appropriate intervention.
risk factors for endometrial cancer in black women

Conditions: Endometrial Cancer

Summary: rationale: learning about the risk factors for endometrial cancer in black women may help the study of endometrial cancer in the future. purpose: this clinical trial is studying risk factors for endometrial cancer in black women.

objectives: * establish and evaluate procedures for conducting a hospital-based case-control study of risk factors for endometrial cancer in black women. outline: this is a multicenter study. participants complete questionnaires about lifestyle factors and their usual diet and measure their waist and hips. saliva or buccal specimens are collected for future research. projected accrual: * a total of 30 cases and 30 controls will be accrued for this study.

Eligibility criteria:
disease characteristics: * cases * diagnosed with endometrial cancer within the past year * self-identified as being black, african-american, black hispanic, african, or afro-caribbean * healthy controls * self-identified as being black, african-american, black hispanic, african, or afro-caribbean * no history of endometrial or other cancer (except non-melanoma skin cancer) * no prior hysterectomy patient characteristics: * speak english * no medical condition that would make it difficult to complete the interview prior concurrent therapy: * see disease characteristics

Keywords: endometrial cancer risk factors questionnaire 07-093
renal allograft tolerance through mixed chimerism

Conditions: End Stage Renal Disease

Summary: this study will examine the safety and effectiveness of a combination kidney and bone marrow transplant from a haplo-identical related donor. an investigational medication and other treatments will be given prior to and after the transplant to help protect the transplanted kidney from being attacked by the body's immune system


Eligibility criteria:
key inclusion criteria: * male or female 18-60 years of age * candidate for a living-donor renal allograft with a one haplotype identical donor identified. * first or second transplant with either a living donor or cadaveric transplant as the first transplant. * positive serologic testing for ebv indicating past exposure. key exclusion criteria: * abo blood group-incompatible renal allograft. * evidence of anti-hla antibody within 60 days prior to transplant as assessed by routine methodology (ahg and/or elisa) * positive testing for: hiv, hepatitis b core antigen, or hepatitis c virus or positivity for hepatitis b surface antigen. * cardiac ejection fraction \< 40% or clinical evidence of insufficiency. * history of cancer other than basal cell carcinoma of the skin or carcinoma in situ of the cervix. * underlying renal disease etiology with a high risk of disease recurrence in the transplanted kidney (such as focal segmental glomerulosclerosis, type i or ii nonproliferative glomerulonephritis). * prior dose-limiting radiation therapy. * abnormal (\>2 times lab normal) values for (a) liver function chemistries (alt, ast, ap), (b) bilirubin, (c) coagulation studies (pt, ptt). * the presence of any medical condition that the investigator deems incompatible with participation in the trial.

Keywords: end stage renal disease renal transplant bone marrow transplant tolerance chimerism esrd
digitally delivered treatments to reduce chronic low back pain

Conditions: Low Back Pain; Chronic Pain (Back / Neck); General Practice (GP), Primary Care Settings; Digital Health; Hypnosis, Chronic Pain Management; Patient Education

Summary: this study aims to evaluate the effectiveness of pain education and clinical hypnosis delivered via a mobile app compared to a guideline-informed factsheet for reducing pain and disability in people experiencing chronic low back pain attending general practice.


Eligibility criteria:
inclusion criteria: * experiencing non-specific chronic low back pain (lbp), defined as pain between the 12th rib and the buttock crease. * lbp with or without leg pain (in case of leg pain, lbp is worse than leg pain). * currently consulting with a general practitioner for their non-specific chronic lbp across australia. * mean pain intensity score on the numeric rating scale ≥ 3/10 in the past week. * a score of at least moderate on question 8 of the physical functioning component of the sf-36 questionnaire. * access to a mobile device with minimal requirements to download the study app (300mb). * an internet connection to access the mobile app functionalities. * able to understand english via reading and audio materials. exclusion criteria: * known or suspected specific spinal (e.g., radiculopathy, fracture) or specific non-spinal non- (e.g., tumour, infection) pathology. * less than six months post-spinal surgery. * scheduled for major surgery during the program or the follow-up period. * known or suspected serious psychiatric condition not being treated by a health professional that would impact adherence to the trial activities. * known or suspected sight or hearing problems that would limit access to the intervention components (reading and listening using headphones).

Keywords: back pain digital health hypnosis pain education chronic pain
autism spectrum disorders (asd) characterization study

Conditions: Autism Spectrum Disorders

Summary: the overarching aim of the study is to characterize children and adults with asds, and compare them with age-matched controls in relation to their functioning in family, academic, employment, and social spheres. subjects will be comprehensively assessed in multiple non-overlapping domains of functioning, using psychiatric, cognitive, and psychosocial instruments.


Eligibility criteria:
inclusion criteria: * age: 6-60 years old * for subjects who have asd: meet dsm-iv pdd criteria based on clinical assessment including pdd module of structured interview * for subjects who have asd: one parent/guardian available for interviews about each subject. if a parent or guardian is not available, a reliable adult reporter identified by the subject available for an interview * full-scale iq of above 80 exclusion criteria: * major sensorimotor handicaps (e.g. deafness, blindness) * any severely unstable psychiatric conditions including the following: psychosis, suicidality, bipolar disorder, substance use disorders (alcohol or drugs) that would require in-patient hospitalization. * inadequate command of the english language.

Keywords: autism spectrum disorder asd autism asperger's syndrome pdd-nos pervasive developmental disorders- not otherwise specified adults children
evaluation of oral and dental health of institutionalized orphan children residing in children's homes in turkey

Conditions: Dental Caries; Orphaned Children; Periodontal Index

Summary: both dental caries prevalence and periodontal status of children residing in children's homes in sivas province of turkey were evaluated.

this study was carried out in 16 state-protected children's homes in sivas under the directorate of coordination of children's homes centres of the ministry of family and social policies of turkey. a total of institutionalized 90 orphan children between the ages of 6 and 18, who did not have any chronic diseases, were not taking medication, and were compliant and healthy, were included in the study. since all participants of this study are under state protection, sivas children's homes center coordination directorate was contacted. the aim of the study and the procedures were explained in detail and official permission was obtained. the children's caregivers signed informed consent forms approved by the ethics committee. the examination procedures were performed by two trained dentists as recommended by the who. dmft and deft, gi and pi indices were used to assess dental caries experience, gingival inflammation, and the amount of plaque on the tooth surface, respectively. also, periodontal status and treatment need were evaluated using the cpitn index.

Eligibility criteria:
inclusion criteria: * does not have any chronic disease. * not taking any medication. * to be compatible and healthy. exclusion criteria: -
mindfulness-based stress reduction for hot flashes

Conditions: Vasomotor Symptoms

Summary: this is a study to determine if participation in a mindfulness-based stress reduction program is feasible for women experiencing five or more hot flashes/day, and whether it affects either the frequency and/or intensity of their hot flashes, or the degree of bother they experience from them


Eligibility criteria:
inclusion criteria: * women experiencing 5 or more hot flashes/day

Keywords: hot flashes mindfulness stress
supplemental postoperative bupivacaine following non-surgical endodontic treatment

Conditions: Pain Assessment; Quality of Life (QOL); Analgesic Use

Summary: the study will investigate the impact of an additional injection of long-acting anesthetic on pain level, quality of life, and use of pain medication after a nonsurgical endodontic treatment. the long-acting anesthetic will be compared to a mock injection group and a group with no additional anesthetic to determine any differences in effects.

the study will investigate the impact of postoperative supplemental long-acting bupivacaine on patient's pain, quality of life, and analgesic use following treatment for symptomatic irreversible pulpitis on patients with pre-operative pain levels of 5 or above (on a 0-10 analog scale). bupivacaine will be compared to a placebo/mock injection and no injection to determine the difference in effect.

Eligibility criteria:
inclusion criteria: 1. medical asa class i or ii 2. patients above 18 years old 3. patients with a blood pressure below 160/100 4. patients who are treatment planned and have agreed to have emergency endodontic therapy or non-surgical root canal therapy with a pulpal diagnosis of symptomatic irreversible pulpitis according to the aae glossary of endodontic terms. 5. patients must be able to comprehend and complete all study protocols, written consent, and questionnaires in english. exclusion criteria: 1. medical asa iii or above 2. patients who reported the use of tobacco or nicotine-containing products such as vapes, e-cigarettes, gums, or pouches and will not in the 48 hours following treatment 3. patients who reported the use of any marijuana products or illicit drugs in the 48 hours prior to treatment and will not in the next 48 hours. 4. patients who have taken opioids to control pain. 5. pregnant patients 6. patients with a blood pressure of 160/100 or greater 7. patients with a known hypersensitivity or allergy to any local anesthetic agent of the amide group, or any other components of the two anesthetic solutions such as epinephrine, sodium metabisulfite used in the study. 8. patients who have more than one tooth with odontogenic pain at the time of the screening. 9. patients who are unable to consent and do not understand or are unable to read the questionnaires. 10. patients who have had 4 1.7 ml carpules or more of anesthetic (lidocaine and/ or septocaine, 1:100,000) during standard care of treatment.

Keywords: bupivacaine nonsurgical endodontic treatment root canal therapy irreversible pulpitis pain management anesthetic use
evaluating safety and efficacy of mesenchymal stem cells from umbilical cord

Conditions: Umbilical Cord Bleeding; Knee Osteoarthritis

Summary: this study was to evaluate the safety and efficacy of mesenchymal stem cells (mscs) from umbilical cord in the treatment of 7 knee oa patients by assessing unexplained local and systemic symptoms or death before and at 1, 2, 3, 6 months after the injection.

this is a single group assignment study with a total of 9 knee osteoarthritis patients participants. all of the patients will receive the anticular injection with mscs from umbilical cord and unexplained local and systemic symptoms or death before the end of following-up will be assessed to evaluate the safety and efficacy of mesenchymal stem cells from umbilical cord.

Eligibility criteria:
inclusion criteria: ① k / l score of 2-3; ② chronic knee pain; ③ no local or systemic infection; ④ without obvious contraindication of the joint puncture from hematology and biochemical tests; ⑤ informed consent. - exclusion criteria: ① older than 75 years old or less than 18 years old, or without full capacity for civil conduct; ② hiv, hepatitis virus or syphilis virus infection or their serology is positive; ③ bmi index is greater than 30; ④ congenital or acquired knee deformity; ⑤ pregnant or lactating women; ⑥ tumor patients; ⑦ immunodeficiency patients; ⑧ intra-articular drug injection history within 3 months; ⑨ participating in other clinical trials; ⑩ other patients who researchers believe are not eligible for inclusion such as suffering from other concomitant diseases. -

Keywords: umbilical cord bleeding knee osteoarthritis stem cells
what do parents know about space maintainers

Conditions: Oral Health; Dental Caries in Children; Tooth Loss

Summary: space maintainers are frequently used to prevent malocclusion problems in early primary tooth loss. oral health literacy is defined as the capacity of individuals to learn, understand and evaluate basic oral health information. it is considered that parents' awareness of space maintainers may be affected by various factors such as their demographic characteristics and oral health literacy. the aim was to evaluate the relationship between variables by determining parents' awareness of space maintainers and their oral health literacy.

this cross-sectional study included 600 children and their parents. the survey, which included questions about sociodemographic characteristics and space maintainer awareness, was administered to parents face to face. then, parents' oral health literacy levels were measured with treald-30 and treald-30a scales.

Eligibility criteria:
inclusion criteria: * patients who did not require urgent treatment, * who did not use medication for psychiatric reasons, * who did not have any mental illness were included. exclusion criteria: * those who did not meet the inclusion criteria were excluded from the study.

Keywords: oral health literacy space maintainer dental caries
enhancement of postocclusive reactive hyperaemia by dipyridamole

Conditions: Hyperemia; Hypoxia

Summary: the purpose of this study is to determine whether dipyridamole enhances postocclusive reactive hyperaemia by increasing extracellular adenosine concentrations during ischemia and reperfusion. furthermore we hypothesize that dipyridamole augments postocclusive reactive hyperaemia by increasing adenosine receptor stimulation.


Eligibility criteria:
inclusion criteria: * healthy volunteers between 18 and 50 years exclusion criteria: * none specified

Keywords: adenosine caffeine dipyridamole
advance cardiac resynchronization therapy (crt) registry

Conditions: Heart Failure

Summary: the intent of this registry is to understand comprehensive clinical care strategies for cardiac resynchronization therapy (crt) patients especially non-responders in real-world clinical practice.

patients who are implanted crt devices will be enrolled in the study. once implanted, all patients will be followed at every 3 months for the first 12 months from the implant. the responder/non-responder evaluation will occur at 6 months from the implant date. the criteria used for determining the response to crt will be captured. during the office follow-up visits, arrhythmic episode diagnoses, device data and stored electrogram will be collected. all clinical events such as hospitalization for heart failure (hf), all-cause hospitalizations, and all-cause death will also be collected. for patients who are non-responders to crt, any re-optimization of the device, i.e., atrioventricular and ventricle-to-ventricle interval optimization, left ventricular (lv) lead repositioning and pacing vector reconfiguration as well as modified/new clinical therapies administered in an attempt to improve hf condition will be collected.

Eligibility criteria:
inclusion criteria: * patient willing and able to sign informed consent * patients implanted with any market-approved st. jude medical crt-d/p device with no prior lv lead placement exclusion criteria: * are likely to undergo heart transplantation within the next 12 months * are less than 18 years of age * are pregnant or planning to become pregnant during the duration of the study * are currently participating in a clinical investigation that includes an active treatment arm * have a life expectancy of less than 6 months
safety and efficacy of carbon dioxide gas for endoscopy

Conditions: Abdominal Pain

Summary: the goal of this clinical trial is to compare the efficacy and safety of air versus carbon dioxide gas insufflation for endoscopy in children. the main question\[s\] it aims to answer are: •to determine safety of co2 assess patient comfort (abdominal pain, flatulence and bloating) with co2 use when compared to air.

in this study, children (6 months -18 years) undergoing all endoscopic procedures that includes an upper endoscopy including but not limited to esophagogastroduodenoscopy (egd/ upper endoscopy), egd/ colonoscopy, endoscopic retrograde cholangiopancreatography (ercp), endoscopic ultrasound (eus) e.t.c after appropriate consent, will be randomized 1:1 to either air or co2 gas for endoscopic insufflation. we will record demographics (name, age, sex, mrn, race/ethnicity), anthropometrics including weight, height/length, weight for length (wfl), wfl z score, bmi, bmi z score, indication/ reason for scope, other co-morbidities (other medical problems), personnel involved (faculty only, vs faculty + trainee), minute by minute end tidal co2 levels, minute by minute minute ventilation levels, baseline blood pco2, and blood pco2 after each procedure. pre and post procedure patient reported abdominal pain, bloating and flatulence. pre and post procedure nurse assessed pain. pre and post procedure vital signs. patients will be randomized using a sealed envelope method by the endoscopy technician. both patients and providers will be blinded to arm of enrollment.

Eligibility criteria:
inclusion criteria: - infants and children 6 months to 18 years undergoing any upper endoscopy related procedure including but not limited to egd/colonoscopy, ercp, egd only, eus, egd with foreign body removal, enteroscopy. exclusion criteria: * patients with american society of anesthesiology (asa) physical status classification system of 4 and above * children with chronic lung disease, * children who are wards of the state will be excluded. * children needing language interpreting services that is not spanish.
a novel technique for endoscopic transaxillary thyroidectomy comparison

Conditions: Thyroid Diseases

Summary: the clinical data from all except the first 20 cases who underwent our novel transaxillary thyroidectomy were collected retrospectively, while the data from patients who underwent conventional open thyroid lobectomy by same surgeon during the same period were used as a control.


Eligibility criteria:
inclusion criteria: 1. the patients with benign or malignant thyroid disease require lobe thyroidectomy; 2. the patient had cosmetic requirements and agreed with transaxillary thyroidectomy; 3. benign lesions with the largest diameter ≤5 cm; 4. differentiated thyroid cancer(dtc) meets the following conditions at the same time: ①the maximum diameter of the primary lesion is \<2.5 cm; ②there is no extraglandular invasion or only minimal external invasion of the anterior thyroid capsule or minor invasion of the sternum thyroid muscle; exclusion criteria: 1. the patients had poor compliance and could not be reexamined regularly; 2. there was a history of neck or thyroid surgery; 3. the patients require total thyroidectomy or lateral neck dissection.

Keywords: endoscopy thyroidectomy transaxillary open