Kornimate/medical-research-clean huggingface dataset:
chemotherapy vs hormonal treatment in platinum-resistant ovarian cancer resistant or refractory to platinum and taxane

Conditions: Ovarian Cancer; Peritoneal Cancer; Cancer of the Fallopian Tube

Summary: a randomized study of chemotherapy versus hormonal treatment in patients with ovarian cancer resistant or refractory to platinum and taxane.

patients with platinum-resistant invasive epithelial ovarian, fallopian tube or peritoneal cancer will be randomized 1:2 to either hormonal treatment with tamoxifen 40 mg daily or chemotherapy of investigator's choice (weekly paclitaxel given as an 1 hour infusion of paclitaxel 80 mg/m2 or pegylated liposomal doxorubicin 40 mg/m2 given every 4 weeks).

Eligibility criteria:
inclusion criteria: * patients with invasive epithelial ovarian, fallopian tube or peritoneal cancer, being resistant to treatment with platinum and a taxane, either given in combination or sequentially. * patients with clinical progression during or within 6 months after end of treatment for primary disease or relapse. * patients with stable disease after 6 courses of chemotherapy for primary disease or relapse if further treatment is indicated. * patients with doubling of s-ca 125 to at least 70 iu/ml within 3 months after end of treatment for primary disease or relapse. * age must be at least 18 years. * performance status must be 0-2 (who/ecog, appendix 1). * informed consent given according to ich/eu gcp guidelines and local or national laws exclusion criteria: * patients with symptomatic brain metastasis * bilirubin greater than 2 x unl (upper normal limits), white blood cell count below 3.0 x 109/l, neutrophil count below 1.5 x 109/l, platelets count below 100 x 109/l. * active infection or other serious underlying medical condition which might prevent the patient from receiving treatment or to be followed. * pregnant, lactating, or child bearing potential patients without adequate contraception * previous treatment with tamoxifen.

Keywords: ovarian cancer platinum-resistant endocrine treatment chemotherapy tamoxifen
electromagnetic positioning-assisted ultrasound guidance in transjugular intrahepatic portosystemic shunt (tips)

Conditions: Portal Hypertension

Summary: transjugular intrahepatic portosystemic shunt (tips) is an important method for treating complications related to portal hypertension. the difficulty of its surgical procedures lies in portal vein puncture. improper operation may lead to complications such as hepatic artery hemorrhage, hepatic capsular hemorrhage, and biliary tract hemorrhage. at present, the means of guiding portal vein puncture are limited. there is evidence supporting that ultrasound guidance can help reduce the number of punctures and lower the radiation dose, etc. however, ordinary ultrasound is limited by the influence of dimensions and can only guide punctures in the same plane, with limited guiding value. the use of the imedis9000 magnetic navigation system can guide percutaneous vascular puncture in multiple dimensions, which can increase the success rate of puncture and shorten the operation time. this study conducted a prospective, single-arm study. the imedis9000 magnetic navigation system was used for real-time positioning to guide precise tips stent implantation. the number of punctures, puncture success rate, stent implantation success rate, and the incidence of adverse events were evaluated to determine the application value of the imedis9000 magnetic navigation system in tips procedure.


Eligibility criteria:
inclusion criteria: * age≥18 years old; * including but not limited to patients requiring tips for: acute esophageal/gastric variceal bleeding, portal hypertensive gastropathy, cirrhotic ascites, cirrhotic hydrothorax, hepatorenal syndrome, budd-chiari syndrome, atypical portal hypertension, portal vein thrombosis, prevention of recurrent esophageal/gastric variceal bleeding, or prevention of recurrent ectopic variceal bleeding; * deemed by clinicians to require transjugular intrahepatic portosystemic shunt (tips) * voluntarily signed informed consent form exclusion criteria: * severe right heart failure, congestive heart failure (ejection fraction \<40%), or severe valvular heart disease; * persistent severe pulmonary hypertension (mean pulmonary artery pressure \>45 mmhg) despite treatment; * uncontrolled systemic infection or inflammation; * hepatic encephalopathy stage iii-iv; * presence of cardiac pacemaker, metallic implants, or other conditions susceptible to electromagnetic interference; * pregnancy or lactation; * poor visualization of the portal venous system on ultrasound; * investigator-determined unsuitability for study participation.

Keywords: tips electromagnetic ultrasound
efficacy of escitalopram in the treatment of internet addiction

Conditions: Internet Addiction

Summary: the purpose of this study was to determine whether lexapro (escitalopram) is safe and effective in treating problematic internet use.

many individuals experience marked distress and functional impairments as a result of their perceived inability to control their 'non-essential' (non-job/school related) use of the internet. frequently these people develop a preoccupation with the internet, a need for escape to the internet, and increasing irritability when trying to cut back use of the internet. there have been no studies to date looking at the effectiveness of medications in the treatment of this disorder. in our clinical experience, we find these patients with internet addiction usually respond to serotonin reuptake inhibitors within 12 weeks. this study will examine the efficacy of escitalopram in internet addiction among adults.

Eligibility criteria:
inclusion criteria: 1. subject has signed an informed consent form 2. current diagnosis of internet addiction 3. age ³ 18 4. subject must be able to take oral medication 5. subject may be in psychotherapy initiated at least three months prior to screening. subject must not discontinue or otherwise alter this therapy during the study. 6. in the opinion of the investigator, the subject is capable of complying with all study procedures. exclusion criteria: 1. current suicidal or homicidal ideation 2. subject has a primary diagnosis of schizophrenia or other psychotic disorders 3. subject has a primary diagnosis of bipolar i disorder 4. current pedophilia 5. current dsm-iv diagnosis of substance dependence or abuse, excluding nicotine 6. women of child-bearing potential who are pregnant, nursing, or not using contraception 7. use of antidepressants at a therapeutic level for the treatment of problematic internet use within 2 weeks prior to study entry (or 4 weeks for use of maois, or 6 weeks for use of fluoxetine) 8. current use of antidepressants at a therapeutic level for the treatment of a disorder other than problematic internet use 9. subject has any organic mental disorder 10. clinically significant unstable medical disorder

Keywords: internet addiction problematic internet use escitalopram lexapro
hcv treatment initiation during acute psychiatric admission

Conditions: Hepatitis C

Summary: hepatitis c virus (hcv) disproportionally affects certain populations, including those facing substance use and mental health challenges. in the past, many individuals with mental illness were not treated due to the psychiatric side-effects of interferon. however, the development of highly effective, direct-acting antivirals (daa) has revolutionized hcv treatment such that cure rates are \>95% with 8-12 weeks of simple, safe, and well-tolerated therapy. a recent systematic review reported that across 13 north american studies, hcv prevalence among people admitted to psychiatric hospitals was a staggering 17.4% (13.2-22.6%). despite these concerning figures, mental health facilities have not been a focus of hcv elimination efforts to date. the centre for addiction and mental health (camh) in toronto is the largest mental health facility in canada, with a psychiatric emergency department seeing \~35 patients per day with many admitted to the acute psychiatric units for safety and stabilization. currently, psychiatric patients screened for hcv at camh have a 75% 'no show' rate at the toronto centre for liver disease (tcld), which is located less than 5km away, suggesting that referral upon discharge is ineffective. this study will be the first trial to evaluate whether it would be feasible and beneficial to initiate treatment during an acute psychiatric admission rather than referring to specialty upon discharge. the combination of broad hcv screening with rapid linkage to treatment has led to successful elimination of hcv within defined populations, so-called micro-elimination. the investigators hypothesize that hcv treatment can be effectively delivered by providers in psychiatric care facilities, which will improve treatment uptake over traditional referral models.


Eligibility criteria:
inclusion criteria: 1. chronic hcv infection, positive hcv rna 2. aged 18 to 80 3. willingness and capacity to provide informed consent, or consent is provided by a substitute decision maker exclusion criteria: 1. presence of or history of decompensated cirrhosis (evidence of decompensation with history of either ascites, variceal hemorrhage, or hepatic encephalopathy) 2. platelets \ 34 μmol/l, inr \>1.5 3. history of current or past hepatocellular carcinoma. 4. hbv (hbsag +ve) co-infection or untreated hiv co-infection 5. prior hcv antiviral therapy with daa with or without peginterferon/ribavirin 6. chronic liver disease other than mild nonalcoholic or alcoholic fatty liver disease from a cause other than hcv 7. pregnancy/breastfeeding/inability to use contraception 8. use of concomitant contraindicated medications

Keywords: hepatitis c psychiatric hospital treatment
the effects of core stabilization exercises in addition to balance exercises in adult hemophilia patients on balance, quality of life, lower limb muscle strength and functional level

Conditions: Hemophilia

Summary: the aim of this study is to investigate the effects of core stabilization exercises in addition to balance exercises on balance, quality of life, lower extremity muscle strength and functional level in adult hemophilic patients.

the aim of this study is to investigate the effects of core stabilization exercises in addition to balance exercises on balance, quality of life, lower extremity muscle strength and functional level in adult hemophilic patients.

Eligibility criteria:
inclusion criteria: * hemophilia patients exclusion criteria: * acute bleeding
adherence in patients receiving pegintron pen/rebetol for hepatitis c in conjunction with a patient assistance program (study p04281)(completed)

Conditions: Hepatitis C, Chronic; Hepacivirus

Summary: patients receiving a patient assistance program during therapy for hepatitis c will be enrolled into this study. all patients will receive pegintron pen and rebetol according to label and the patient assistance program. this study will be compared to similar studies from other clinics using various patient support programs for the purpose of designing future comparative phase iv studies.


Eligibility criteria:
inclusion criteria: * adult patients with hepatitis c exclusion criteria: * according to the products' labeling (refer to warnings, contraindications, and safety sections).
folfox/bevacizumab with onartuzumab (metmab) versus placebo as first-line treatment in patients with metastatic colorectal cancer

Conditions: Colorectal Cancer

Summary: this randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of folfox/bevacizumab with onartuzumab (metmab) versus placebo as first-line treatment in patients with metastatic colorectal cancer.


Eligibility criteria:
inclusion criteria: * adult patients, \>/= 18 years of age * histologically or cytologically confirmed adenocarcinoma of the colon or rectum in patients with metastatic (stage iv) disease * eastern cooperative oncology group (ecog) performance status 0 or 1 * measurable disease by recist criteria * adequate organ system function, as defined by protocol exclusion criteria: * prior systemic or radiation therapy for metastatic colorectal cancer * adjuvant chemotherapy (and/or chemoradiation) for colorectal cancer within 12 months prior to date of diagnosis of metastatic disease * previously untreated brain metastases * history of hypersensitivity to active or inactive excipients of any component of treatment, or known dipyrimidine dehydrogenase deficiency * evidence of bleeding diathesis or significant coagulopathy (in the absence of therapeutic anticoagulation) * history of hematemesis or hemoptysis \</= 1 months prior to study enrollment * significant cardiovascular disease or disorder * history of abdominal fistula or gastrointestinal perforation \</= 6 months prior to day 1 * positive for hepatitis b, hepatitis c or hiv infection * other active cancers or history of treatment for invasive cancer within the last 5 years, except for non-melanoma skin cancer
randomized control trial of intraperitoneal bupivacaine during cholecystectomy

Conditions: Cholecystitis; Gall Stone Pancreatitis

Summary: laparoscopic cholecystectomy (removal of the gall bladder via 'keyhole surgery') is a common procedure. this can be performed as an emergency operation when a patient has a complication of gall stones such as acute inflammation or pancreatitis. there are several trials which demonstrate that placing local anaesthetic inside the abdomen at the site of gall bladder surgery during a planned elective operation decreases post operative pain. this is the first trial to investigate the efficacy of this local anaesthetic during emergency cholecystectomy.

background several studies, including a metanalysis, have demonstrated that intraperitoneal local anaesthetic (ip la) during elective laparoscopic cholecystectomy (el-lc) decreases post operative pain. none have explored the efficacy of ip la at emergency laparoscopic cholecystectomy (em-lc). a longer operation duration, greater frequency of washing and the inflammation associated with cholecystitis or pancreatitis are a few reasons why it cannot be assumed that a benefit in pain scores will be seen in em-lc with ip la. this study assesses the efficacy of ip la used in patients undergoing em-lc. methods double blind randomised sham controlled trial of 42 consecutive subjects undergoing em- lc. ip-la was delivered by a combination of direct injection to the diaphragmatic and topical wash over the liver/gall bladder with bupivacaine or sham depending upon allocation. the primary outcome was vas pain scores on the ward. secondary outcomes included vrs pain scores in theatre recovery, analgesic use, physiological observations, time to eating and ambulation and length of postoperative stay. results one patient had a procedure converted to open and was excluded. there was no significant difference in pain scores on the ward or in theatre recovery. analgesic use, respiratory rate, oxygen saturation, duration to ambulation, eating, satisfaction scores and time to discharge were comparable between the groups. conclusions intraperitoneal la during em-lc does not influence post-operative pain. other modalities of analgesia should be explored as well as decreasing the interval between diagnosis of acute admission and em-lc.

Eligibility criteria:
inclusion criteria: * patients undergoing emergency cholecystectomy for cholecystitis or gall stone pancreatitis exclusion criteria: * patients undergoing planned elective cholecystectomy

Keywords: emergency laparoscopic cholecystectomy pain scores intraperitoneal local anaesthesia cholecystitis
gross motor abnormalities in relation to balance and weight indicators in diplegia

Conditions: Spastic Diplegia Cerebral Palsy

Summary: the goal of this observational study is to investigate the correlation between bmi and balance and gross motor capacities in children with spastic diplegia. the main question it aims to answer is: is there a correlation between bmi, balance disturbances and gross motor capacity in children with spastic diplegic cerebral palsy? researchers compared between results of biodex balance system , gmfm and bmi measures participants stood on biodex balance platform for balance measurement and performed gross motor function measurement items for gross motor capacities assessment

spastic diplegia is the most common type of cp that results in problems with posture, balance, as well as gait control. for children suffering from spastic diplegic cp, balance problems provide a significant difficulty since they make it difficult for them to achieve and maintain balance . additionally, they commonly demonstrate delayed development of gross motor function that has been connected to functional outcomes, such as daily living tasks . the prevalence of obesity in the cp population has risen over the last decade from 7.7 to 16.5 %. . obesity is associated with health risks and difficulties in balance and walking. this cross-sectional-correlation study was conducted at the outpatient clinic at the faculty of physical therapy, cairo university. the study included 104 diplegic children aged from 5-10 years, 53 in normal weight group and 51 in overweight group. dynamic balance was evaluated by overall stability index (osi) in biodex balance system and gross motor capacities (gmc) were evaluated by standing \&walking dimensions in gmfm

Eligibility criteria:
inclusion criteria: children selected according to the following criteria: * diagnosed with diplegic cp * their ages will range between 5 and 10 years * subjects will participate according to bmi classification ; normal weight in the first group and (obese , overweight) in the second group . * they must be able to stand independently. * have minimum height of 100 cm. * have a developmental level of grade i or ii according to gross motor function classification system gmfm. * able to understand and follow instructions. exclusion criteria: * auditory defects. * visual defects. * cognitive or vestibular defects. * use of an assistive device. * fixed deformity, bony or joint limitation. * surgery (tendon lengthening).

Keywords: bmi balance gross motor capacities obesity diplegia
growth mindset psychoeducation for modifiable risk factors for cmd

Conditions: Depression, Anxiety

Summary: the present study aims to determine the effect of presenting psychoeducation emphasizing "growth-mindset," and information on modifiable risk factors (e.g., social contact, physical activity) on engagement with modifiable risk factors. the investigators hypothesize that psychoeducation emphasizing that mental health is malleable will increase the participant's engagement with risk factors outlined in the intervention.


Eligibility criteria:
inclusion criteria: * college freshmen exclusion criteria: * not fluent in english
assessment of oncological and functional outcomes after robot assisted partial nephrectomy versus laparoscopic partial nephrectomy

Conditions: Kidney Neoplasms

Summary: currently, partial nephrectomy (pn) is considered as the gold standard treatment modality for small renal masses. in this setting, robot-assisted and conventional laparoscopic approaches are gaining more consensus every day. however, until now, no superiority of one technique over the other has yet been demonstrated, especially on postoperative function recovery. this study compares oncological and functional outcomes after laparoscopic partial nephrectomy versus robot assisted partial nephrectomy.

renal cell carcinoma (rcc) represents 2-3% of all cancers, with the highest incidence in western countries. due to increased detection of tumors by ultrasound (us) and computed tomography (ct), the number of incidentally diagnosed rccs has increased. these tumors are usually smaller and of lower stage. currently, partial nephrectomy (pn) is considered as the gold standard treatment modality for small renal masses. in this setting, robot-assisted and conventional laparoscopic approaches are gaining more consensus every day. however, until now, no superiority of one technique over the other has yet been demonstrated, especially on postoperative function recovery. this is a single center prospective randomized trial investigating the functional and oncological outcomes of minimally invasive (laparoscopic and robot-assisted) nephron sparing surgery. patients will be assessed with renal scintigraphy and 24 hours creatinine clearance pre- and postoperatively. furthermore, duration of the operation, resection and suturing times will be assessed. renal function recovery is defined as primary endpoint; oncological outcome and positive surgical margin rate are defined as secondary measures. in addition, kidney volume variation will be calculated to describe the amount of healthy tissue preserved in both procedures.the aim of the study is to assess whether robot assisted partial nephrectomy in selective ischemia is superior to laparoscopic partial nephrectomy in global ischemia in terms of functional and oncological outcomes.

Eligibility criteria:
inclusion criteria: * men and women \>18 years * organ-confined renal cancer (tumor stage ct1-ct2), assessed by mri/ct * patient qualifies for robotic or laparoscopic partial nephrectomy * written informed consent exclusion criteria: * renal masses necessitating radical tumor nephrectomy * patients with single kidney * bilateral kidney cancer when simultaneously operated * previous partial nephrectomy * renal insufficiency: chronic kidney disease (ckd) stages 4-5

Keywords: renal cell carcinoma laparoscopic partial nephrectomy robot-assisted partial nephrectomy nephron sparing surgery warm ischemia time renal function loss