Kornimate/medical-research-clean huggingface dataset:
predictive analysis of diabetic foot ulcer

Conditions: Diabetic Foot Ulcer (DFU); Diabetic Foot Disease; Diabetes

Summary: the purpose of this study was to retrospectively analyze the wound condition, limb condition, ulcer recurrence and cardiovascular and mortality of patients with diabetic foot ulcer after admission to our hospital from 2009 to 2014, so as to understand the changes in the condition of patients with diabetic foot ulcer after treatment, provide evidence for the treatment of diabetic foot, and clarify the risk of diagnosis and treatment of diabetic foot.

diabetic foot ulcer (dfu) is one of the most common and serious complications in patients with diabetes. due to its high incidence and complicated treatment process, dfu often has a significant impact on patients' quality of life. in order to gain an in-depth understanding of the wound changes of diabetic foot patients after admission, this study aims to systematically analyze the data of the database of diabetic foot patients in ruijin hospital, analyze the wound healing, ulcer recurrence and limb changes of diabetic foot patients, including amputation and other conditions, and then further determine the main factors affecting diabetic foot ulcer healing. guide clinicians to develop more effective treatment plans; provide data support to help optimize the treatment flow of diabetic foot and reduce length of stay and recurrence rates; to improve the overall treatment effect of diabetic foot patients and improve their quality of life. objective: 1. the wound condition, limb condition, ulcer recurrence and cardiovascular and mortality changes of patients with diabetic foot after treatment were analyzed to clarify the risk of diagnosis and treatment of the disease and provide evidence for the treatment of diabetic foot. 2. to assess the progress of wound healing in patients with diabetic foot after admission to hospital and identify key factors that promote or delay healing. 3. by comparing the effects of different treatment methods (such as drug therapy, surgical intervention, adjuvant therapy, etc.), the most suitable treatment strategy is found. 4. the incidence of complications during and after treatment was analyzed, and effective management strategies were discussed. methods:through systematic analysis of the data from the database of diabetic foot patients in ruijin hospital, the wound healing, ulcer recurrence and limb changes of diabetic foot patients, including amputation, were analyzed, and then the main factors affecting diabetic foot ulcer healing were further determined.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years old 2. gender: males and females 3. patients diagnosed with diabetic foot ulcers (including those on the wagner scale 0-5) 4. receive inpatient treatment during the designated study period exclusion criteria: 1. patients with severe systemic disease (such as end-stage renal disease, advanced cancer, etc.) may have influenced the study results 2. patients unable to complete follow-up or with incomplete data
sublocade rapid initiation extension study

Conditions: Opioid Use Disorder, Severe; Opioid Use Disorder, Moderate

Summary: a single center, open-label sublocade treatment extension study in which up to 25 participants diagnosed with moderate to severe opioid use disorder (oud) could be enrolled.

this study is being conducted to assess the longer-term safety of an abbreviated initiation protocol of sublocade in subjects who have completed the indv-6000-403 study. it is also to provide treatment to these individuals while they seek longer-term treatment arrangements, as on average it can take an individual with opioid use disorder (oud) 6 months between seeking treatment and achieving an appointment at a provider in the united states (us). subjects who have completed the end of treatment (eot) procedures for the indv-6000-403 study may be eligible for participation. it is planned that the eot visit for indv-6000-403, which will occur approximately 28 days after the subject's first dose of sublocade, and day 1 for indv-6000-404 will occur within 2 days of the eot visit, and that eot assessments will serve as the screening assessments for this study. on day 1, eligible subjects will receive a subcutaneous (sc) injection of 300 mg sublocade. subjects will return to the clinic for subsequent injections approximately every 4 weeks for a total of up to 5 injections. adverse events and concomitant medications will be captured throughout the study, female subjects of childbearing potential will receive urine pregnancy tests and all subjects will have urine drug screening (uds) and evaluation of the previous injection site performed. subjects will otherwise be treated in accordance with local standard of care, and sublocade doses will be based on the medical judgment of the investigator.

Eligibility criteria:
inclusion criteria: * signed the informed consent form (icf) and have the ability to comply with the requirements and restrictions listed therein. * completed the eot visit for the indv-6000-403 study. * is an appropriate candidate in the opinion of the investigator or medically qualified sub-investigator. exclusion criteria: * subject compliance issues during participation in the indv-6000-403 study which, in the opinion of the investigator, could potentially compromise subject safety. * subjects who are unable, in the opinion of the investigator or indivior, to comply fully with the study requirements including those who are currently incarcerated or pending incarceration legal action.
long-term follow-up in patients with deep brain stimulation (dbs) for obsessive compulsive disorder (ocd).

Conditions: Obsessive Compulsive Disorder (OCD)

Summary: for this human research, 17 treatment-refractory ocd patients who already received dbs implants for treatment refractory ocd between june 1998 and october 2007 will be included. new patients that complete the protocol on "refining the target for dbs in ocd" will be included in this follow-up study as well. they will be psychiatrically evaluated on regular bases: at least twice yearly in the years two to five after surgery, at least once a year for the years thereafter. the duration of this protocol is indefinite, but spans at least 10 years. the main aim of this study is to investigate the long-term effect of dbs in ocd patients.


Eligibility criteria:
inclusion criteria: * patients who have received dbs implantation for the treatment of ocd exclusion criteria: -

Keywords: obsessive compulsive disorder (ocd) deep brain stimulation (dbs) psychosurgery long-term follow-up
a study of certain prevail implants used for the preservation of crestal bone in short fixed bridge cases.

Conditions: Partial Edentulism; Tooth Disease

Summary: this prospective, randomized study will evaluate the performance of the osseotite certain prevail implant when compared to that of the non-lateralized version of the implant. study (null) hypothesis: the crestal bone changes that take place after placement and loading of the osseotite lateralized implants will be the same as for a similar but non-lateralized osseotite certain implant.

this is a prospective, randomized, longitudinal study in which qualified patients with partial edentulism will receive a short-fixed bridge restoration. each implant site is randomized to receive either the osseotite certain lateralized (test) or the osseotite certain non-lateralized (control). all implants will receive a temporary prosthesis after two months of placement. enrollment will include up to 20 patients (approximately 60 implants per center) at each participating study center.

Eligibility criteria:
inclusion criteria: * patients of either sex and any race greater than 18 years of age * patients for whom a decision has already been made to use dental implants for treating an existing condition specifically: a partially edentulous short-span fixed case of less than 4 implants in the maxilla or mandible; the prosthesis may be anterior, posterior, or transitionally anterior-posterior; no cantilevers allowed but one interior crown may be a pontic * patients must be physically able to tolerate conventional surgical and restorative procedures * patients must agree to be evaluated for each study visit, especially the yearly follow-up visits exclusion criteria: * patients with active infection or severe inflammation in the areas intended for implant placement * patients with a \>10 cigarette per day smoking habit * patients with uncontrolled diabetes mellitus * patients with metabolic bone disease * patients who have had treatment with therapeutic radiation to the head within the past 12 months * patients in need of allogenic bone grafting a the site of the intended study implant * patients who are pregnant at the screening visit * patients with evidence of severe para-functional habits such as bruxing or clenching * patients with cantilevers and more than one pontic per bridge

Keywords: dental implants osseotite certain prevail lateralized non-lateralized osseotite certain multicenter randomized clinical study partial edentulism single stage early loading crestal bone level short fixed bridge
effects of aerobic training in diabetic vs non-diabetic post-stroke patients

Conditions: Stroke

Summary: the study aims to investigate the effects of aerobic training in post-stroke patients, both diabetic and non-diabetic, in terms of their metabolic response to exercise and psychosocial well-being. it is crucial to understand the metabolic changes that occur due to stroke and diabetes, including glucose and lipid profiles.

the study will explore how aerobic training can influence insulin sensitivity and lipid metabolism differently in diabetic and non-diabetic patients, which may affect overall recovery outcomes. it is also essential to assess psychosocial well-being, including depression and satisfaction with life. aerobic exercise has been shown to improve mood and enhance overall quality of life in post-stroke patients. by assessing these variables comprehensively, tailored rehabilitation strategies can be developed to optimise metabolic and psychosocial outcomes in diabetic and non-diabetic post-stroke populations, ultimately improving overall well-being and quality of life.

Eligibility criteria:
inclusion criteria: * male and female post-stroke patients will be inactive or insufficiently active. * the patient's age ranged from 18 to 74. they will have a balanced sitting position or can ambulate. * the stroke will not last less than six months and not more than two years. * exercises will be performed at a vigorous intensity greater than 60% of the individual's maximum cardiorespiratory capacity. * patients with adequate cognitive abilities (mini-mental scale \>24) to understand and obey instructions exclusion criteria: * unconscious patients or communication problems that could prevent them from completing the tests used in the study. * those with bilateral or previous hemiplegia and sensory aphasia * comorbid neurological diseases (multiple sclerosis, parkinson's disease, spinal cord injury, traumatic brain injury, brain tumour, etc. * those with any contraindications for the maximum exercise test * cardiovascular or pulmonary conditions (unsettled angina, current myocardial infarction during the last three months, congestive heart failure, severe heart valve dysfunction) * musculoskeletal problems such as extreme arthritis and fracture
outcomes of covid-19 protective measures in endoscopy

Conditions: Covid-19 Disease; Endoscopy Unit

Summary: prospective study evaluating the outcomes of implementation of a protective protocol for covid-19 for patients and staff in a large endoscopy unit.

detailed description: sars-covid-19 virus pandemic has had a big impact both socially and on operation of health facilities. during the covid-19 outbreak most of the scheduled endoscopies were cancelled and only emergent and urgent endoscopies were performed in the unit. this meant that for six weeks, around 98% of our daily workload was cancelled. during that time the investigators have developed a protocol in order to resume scheduled endoscopic activity in the decreasing phase of the pandemic. the hypothesis of this prospective observational study is that implementation of a protocol based upon covid pcr tests and clinical triage is useful to categorize two types of covid-19 infection risk and two levels of personal protection equipments required. the primary aim is to evaluate the outcomes of implementing a protective protocol with two levels of protection for covid-19 in the endoscopy unit. as secondary aims, the investigators, want to evaluate the endoscopy unit staff and patients infection rate after implementation of the protective protocol; and the utility of previous covid pcr testing and on day clinical triage to discriminate patients before endoscopy. a brief daily questionnaire will be filled by all the endoscopy unit staff members questioning about type of procedures performed in their allocated endoscopy room, level of protection used and pcr status of their attended patients. patients will be followed up for a period of two weeks to discard development of covid-19 disease with possible origin in their visit to the endoscopy unit.

Eligibility criteria:
inclusion criteria: * patients undergoing an endoscopic procedure with written informed consent given. * staff allocated in the endoscopy unit. exclusion criteria: * refection to participate in the study.

Keywords: covid-19 disease endoscopy gastrointestinal personal protective equipment
dexamethasone palmitate for ponv after minimally invasive endoscopic surgery

Conditions: Postoperative Nausea and Vomiting; Dexamethasone Palmitate; Minimally Invasive Endoscopic Procedures

Summary: dexamethasone is almost one of the most commonly used drugs for postoperative nausea and vomiting (ponv) prevention. however, ponv is still a complex problem to be solved; for example, even with preoperative dexamethasone administration, 14.0-26.3% of patients undergoing minimally invasive endoscopic procedures still experience ponv within 24 hours postoperatively. compared to dexamethasone, dexamethasone palmitate has a long-lasting anti-inflammatory effect, 2-5 times that of traditional water-soluble dexamethasone, with fewer adverse effects. this trial aims to assess the effect and safety of preoperative dexamethasone palmitate on ponv after surgery.


Eligibility criteria:
inclusion criteria: * aged 18 to 65 years; * providing written informed consent; * perform elective minimally invasive endoscopic surgery (laparoscopic surgery, thoracoscopic surgery) undergoing general anesthesia. exclusion criteria: * known to be allergic to dexamethasone; * any systemic glucocorticoids within 3 months before trial entry; * history of severe heart disease, liver/kidney failure, or systemic rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, et al); * cognitive impairment or severe mental illness; * uncontrolled diabetes or infectious diseases; * pregnancy or breastfeeding.
tb-capt core truenat trial

Conditions: Tuberculosis; Diagnoses Disease

Summary: a cluster randomized controlled trial to evaluate the effect of placing truenat platform/tb assays at primary health care clinics combined with rapid communication of results on time to treatment initiation of microbiologically confirmed tb.

a cluster randomized controlled trial to evaluate the effect of placing truenat platform/tb assays at primary health care clinics combined with rapid communication of results on time to treatment initiation of microbiologically confirmed tb. in a setup period (survey of study centers) before randomization, the healthcare facilities (=clinics) of 4 sites will be asked to provide information about the number of tb notifications per quarter covering the period 1/2018-6/2020. from this information the foreseeable number of examined patients ("size of a clinic") will be derived, which will be used as a strata variable in randomization process. facilities will be randomly allocated to the standard of care (control), or truenat platform/tb assays (intervention). a cluster refers to a clinic. the clusters will be assigned to intervention or control arm to one of two diagnostic procedures (soc \[smear microscopy and/or xpert mtb/rif ultra off-site\] vs truenat platform/tb assays on-site) following a restricted randomization strategy, whereby 6 to 8 strata of clusters will be established using the stratification variables site (clinics belong to a site) and size and apply balance criteria for them. the number of strata per site depends on heterogeneity of the sizes of the clinics as established in setup period and may be increased, typically 1 or 2 strata per site will be established. the primary endpoint will be compared in an individual level analysis with strata and intervention as fixed effects and cluster as random effect.

Eligibility criteria:
inclusion criteria: * patients with presumptive pulmonary tb, as defined by the national tb treatment guidelines in each country: patients with cough more than 1-2 weeks and/or fever, night sweats, blood-stained sputum (haemoptysis) significant weight loss, abnormalities on chest radiograph * adults 18 years old and above who are able and willing to consent exclusion criteria: * circumstances that raise doubt on free, informed consent (e.g. in a mentally impaired person or a prisoner) * already diagnosed with tb * currently receiving anti-tb therapy * patients with symptoms which are only attributable to extra-pulmonary tb * patients who are seriously ill and need to be admitted to hospital
klotho and mineral bone density in systemic sclerosis

Conditions: Systemic Sclerosis

Summary: the present study recruits female patients aged 45-65 years with a diagnosis of systemic sclerosis according to the eular/acr 2013 criteria and age and gender-matched healthy control subjects. the purpose of the study is to investigate the possible role of klotho and other cytokines involved in the osteoimmunological control of bone turnover as a possible determinant of the microvascular damage and fibrosis observed in ssc patients

the present study recruits female patients aged 45-65 years with a diagnosis of systemic sclerosis according to the eular/acr 2013 criteria and age and gender-matched healthy control subjects. the purpose of the study is to investigate the possible role of klotho and other cytokines involved in the osteoimmunological control of bone turnover as a possible determinant of the microvascular damage and fibrosis observed in ssc patients . for each patient demographic data, history of fractures and smoking habits will be gathered. evaluation of bone mineral density will be performed and blood samples to dose ddk1, sclerostin, osteoprotegerin and klotho will be collected.

Eligibility criteria:
inclusion criteria: * female gender * systemic sclerosis diagnosis * signature of the informed consent exclusion criteria: * chronic kidney disease * liver or thyroid disease * diabetes * ongoing diuretic treatment * estrogen replacing treatment * vitamin d or calcium supplementation * drugs able to interfere with bone turn-over (such as bisphosphonates or glucocorticoids)
cord blood transplantation for patients with cancer

Conditions: Hematological Disease

Summary: the primary objective of this study is to assess the rate of engraftment with combined haploidentical-cord blood transplantation in patients with pre-existing donor specific antibodies and in those with active disease.

primary objective - to assess the rate of engraftment with combined haploidentical-cord blood transplantation in patients with pre-existing donor specific anti-hla antibodies and in those with active disease secondary objectives * to determine the long term fate of the haplo transplant and the cord blood transplant in this setting. * to describe the incidence and severity of acute and chronic gvhd.

Eligibility criteria:
inclusion criteria: * relapsed or refractory acute leukemia (myeloid or lymphoid) * acute leukemia in first remission at high-risk for recurrence * chronic myelogenous leukemia in accelerated phase or blast-crisis * chronic myelogenous leukemia in chronic phase * recurrent or refractory malignant lymphoma or hodgkin lymphoma * chronic lymphocytic leukemia, relapsed or with poor prognostic features * multiple myeloma * myelodysplastic syndrome * chronic myeloproliferative disease * hemoglobinopathies * aplastic anemia exclusion criteria: * zubrod performance status \> 2 * life expectancy is severely limited by concomitant illness * patients with severely decreased lvef or impaired pulmonary function tests * estimated creatinine clearance \<50 ml/min * serum bilirubin\> 2.0 mg/dl or sgpt \>3 x upper limit of normal * evidence of chronic active hepatitis or cirrhosis * hiv-positive * patient is pregnant * patient or guardian not able to sign informed consent
impact of a pharmacovigilance program led by advanced practice nursing

Conditions: Adverse Drug Event

Summary: hypothesis an advanced practice nursing intervention in the area of pharmacovigilance performed on patients and professionals improves the identification and reporting of suspected adverse drug reactions (adr) and improves the overall experience of hospitalized patients.

primary objetives 1. to assess whether an advanced nursing intervention improves the identification and reporting of suspected adr. secondary objectives 1. to determine if an advanced nursing intervention improves the experience related to the use of medications measured through the qexpac-21 patient experience questionnaire. 2. identify which factors associated with medications increase the risk of adrs and the characteristics of the patients. 3. know the incidence and describe adrs: severity, preventability, and causality using validated scales. 4. describe the degree of nursing intervention according to the north american nursing diagnosis association (nanda) taxonomy, and the classification of nursing interventions (nic) related to drug use. 5. quantify the number of interconsultation generated by patients and professionals related to the use of drugs. 6. determine the degree of adherence and compliance with the regimens prescribed to the patients. study design prospective, randomized and controlled study of an intervention that compares a group of patients according to the usual practice of the nursing care process, against another on which a more intensive nursing intervention is carried out for the identification and notification of adrs. it is carried out on a representative sample of patients admitted to a tertiary level hospital with 860 beds of the madrid health service during the year 2022.

Eligibility criteria:
inclusion criteria: 1. patients with pharmacological treatment. 2. patients of both sexes aged between 0 and 100 years. 3. patients admitted to medical or surgical hospitalization units or emergency services for at least 24 hours. 4. patients who have received the information and agreed to participate in the study. exclusion criteria: 1. patients included in other clinical trials or drug studies at the time of selection. 2. patients with significant cognitive impairment, without adequate family support or primary caregiver. 3. patients and/or caregivers who, once offered to participate in the study, do not give their consent 4. impossibility of communication due to language barriers or other biopsychosocial problems.