Kornimate/medical-research-clean huggingface dataset:
clinical evaluation of tunneled coronally advanced flap v.s coronally advanced flap with graft for gingival recession

Conditions: Gingival Recession, Localized

Summary: the goal of this clinical trial is to evaluate gingival recession depth reduction using tunneled coronally advanced flap compared to coronally advanced flap, both combined with connective tissue graft in patients with isolated rt2 gingival recession sites.

gingival recession can cause clinical conditions that could be of main concern for patients. techniques aiming for coverage of the gingival recession aim to address dentin hypersensitivity, non-carious cervical lesions (nccls) and enhance patient's esthetics (cortellini \& bissada, 2018). mid-buccal gingival recessions have been associated with patient's esthetic discomfort (zucchelli \& mounssif, 2015). most of the studies in the literature focus on the treatment of rt1 recession as they have the most favorable prognosis of full root coverage (barootchi et al., 2020). despite most studies focusing their attention on rt1 cases, rt2 defects are found to be the most prevalent type with 88.8% among patients according to (romandini et al., 2020). the coronally advanced flap and the tunneling technique are the most commonly performed surgical approaches for treating gingival recessions. however, these two approaches have commonly been regarded as alternatives to each other, with clinicians choosing to perform only one of them during root coverage procedures. (barootchi \& tavelli, 2022) aimed in his conducted case series to designate a surgical technique to treat isolated rt2 gingival recession defects in which he was trying to achieve and combine the advantage of both better access and graft stabilization in caf and the preservation of the integrity of the papilla and better blood supply to the graft present in tunneling technique. the study concluded that the combination of both techniques in the same surgical design can have the potential to enhance flap and graft vascularization and improve clinical, esthetic, and patient-reported outcomes. to our knowledge, there is no conducted randomized clinical trials comparing the tunneled coronally advanced flap technique to the coronally advanced flap for gingival depth reduction. so, this clinical trial aims to address this gap of the literature.

Eligibility criteria:
inclusion criteria: 1. patients age 18 years or older. 2. isolated recession defect classified as rt2. 3. patients with healthy systemic condition. 4. clinical indication and/or patient request for root coverage. 5. o'leary index less than 20%. exclusion criteria: 1. pregnant females 2. smokers: a contraindication for any plastic periodontal surgery. 3. unmotivated and uncooperative patients with poor oral hygiene 4. patients with habits that may compromise the longevity and affect the result of the study as alcoholism or parafunctional habits.

Keywords: tcaf caf rt2 gingival recession depth reduction
transcranial direct current stimulation as a neuroprotection in acute stroke before and after thrombectomy

Conditions: Acute Ischemic Stroke

Summary: this proposal is a prospective, single-center, dose-escalation safety, tolerability, feasibility and potential efficacy study of transcranial direct current stimulation (tdcs) in acute stroke patients with substantial salvageable penumbra due to a large vessel occlusion before and after endovascular therapy.

this is a single-center, sham-controlled, dose-escalation study where cathodal tdcs is delivered to threatened but not yet irreversibly damaged (penumbral) tissue in patients with large vessel occlusion who are undergoing recanalization procedure. patients will be randomized in a 3:1 design, to cathodal versus sham (control) stimulation, at each six designed dose tiers. the dose tiers will be increasing in both intensity and duration of the stimulation. all patients will be receiving the first dose (stimulation cycle) after the recanalization procedure and patients at dose tiers 5-6 will also be receiving stimulation cycles before the recanalization procedure begins. the occurrence of symptomatic intracranial hemorrhage will determine the pace of the escalation through the dose tiers.

Eligibility criteria:
inclusion criteria * new focal neurologic deficit consistent with ais * age≥18 * nihss ≥ 4 * ica or m1 or m2 mca occlusion on pre-thrombectomy mra or cta * onset (last-seen-well) time to randomization time within 24 hours * pre-stroke modified rankin scale≤ 3. * patient ineligible for iv tpa, per national aha/asa guidelines. * having undergone endovascular thrombectomy with less than a complete reperfusion (\<tici 2c, 3) for receiving post-thrombectomy adjunct c-tdcs. * undergoing endovascular thrombectomy, per national aha/asa guidelines for patients who are assigned to pre-thrombectomy bridging session at tiers 5, 6. * a signed informed consent is obtained from the patient or patient's legally authorized representative exclusion criteria * acute intracranial hemorrhage * evidence of a large ischemic core volume (adc \< 620 µm2/s or rcbf\< 30%) ≥ 100 ml * presence of tdcs contraindications - electrically or magnetically activated intracranial metal and non-metal implants. * pregnancy * severe contrast allergy or absolute contraindication to iodinated contrast preventing endovascular intervention. * history of seizure disorder or new seizures with presentation of current stroke * evidence of any other major life-threatening or serious medical condition that would prevent completion of the study protocol including attendance at the 3-month follow-up visit * concomitant experimental therapy * preexisting scalp lesion at the site of the stimulation or presence of skull defects (may alter current flow pattern) * preexisting coagulopathy, consist of a platelet count of ≤ 100, inr ≥ 3, ptt ≥ 90.

Keywords: transcranial direct current stimulation bridging neuroprotection adjunctive neuroprotection
expanded access program of dupilumab in adults with severe immunoglobulin e (ige)-mediated food allergy who have been previously treated with linvoseltamab and background dupilumab in the parent study r5458-668-alg-2219 (nct06369467)

Conditions: Food Allergy

Summary: this is an expanded access program of dupilumab that was never initiated and, therefore, not available.


Eligibility criteria:
anesthetics to prevent lung injury in cardiac surgery

Conditions: Inflammatory Lung Injury; Ischemia-Reperfusion Lung Injury; Postoperative Pulmonary Complications

Summary: the purpose of this study is to investigate whether the use of inhaled anesthetics, compared to intravenous anesthetics, can affect the amount of lung inflammation and postoperative respiratory complications seen after cardiac surgery.

randomized, controlled trial involving 45 adult patients undergoing cardiac surgery with cardiopulmonary bypass. patients will be randomized to receive either inhaled anesthesia with sevoflurane or total intravenous anesthesia (tiva) with propofol for the maintenance phase of their cardiac anesthetic. assessment of lung inflammation will take place using fiberoptic bronchoscopic sampling of lung fluid as well as serum collection before and after exposure to cardiopulmonary bypass, and the incidence of compositive postoperative pulmonary complications will take place in the postoperative period.

Eligibility criteria:
inclusion criteria: * adult patients (age 18+) * undergoing cardiac surgery with cardiopulmonary bypass exclusion criteria: * emergency surgery * history of severe copd, emphysema, or ild * recent (\<2wk) or current use of systemic glucocorticoids * prior history of pneumothorax * allergy/contraindication to intravenous anesthetics * personal or family history of malignant hyperthermia or high risk for malignant hyperthermia

Keywords: volatile anesthetics intravenous anesthetics inflammatory lung injury postoperative pulmonary complications cardiac surgery cardiopulmonary bypass
diagnostic accuracy of 3-dimensional imaging device on polyps and adenomas during colonoscopy

Conditions: Colorectal Polyps; Colorectal Adenomas

Summary: the goal of this clinical trial is to learn if 3-dimensional (3d) imaging device works to correctly classify colon polyps and adenomas during colonoscopy to guide the selection of proper treatment procedures. it will also learn about the safety of 3-dimensional (3d) imaging device. the main questions it aims to answer are: does 3-dimensional (3d) imaging device improve the correct classification as well as size and depth evaluation of polyps and adenomas during colonoscopy using pathology as gold standard? what adverse events do participants experience during colonoscopy and polypectomy? researchers will compare 3-dimensional (3d) imaging device to traditional 2-dimensional (2d) imaging device to see if 3-dimensional (3d) imaging device works to improve classification and evaluation accuracy. participants will: undertake colonoscopy examination and polypectomy using 3-dimensional (3d) imaging device or 2-dimensional (2d) imaging device. be followed-up to 30 days to record potential colonoscopy-relevant adverse events.


Eligibility criteria:
inclusion criteria: * aged over 18 years; * endoscopically diagnosed with colorectal polyps; * signing the written informed consent. exclusion criteria: * patients with mental illness or severe functional disorder who cannot cooperate with colonoscopy; * patients with severe cardiopulmonary insufficiency; * patients with severe coagulation disorders or high bleeding risk (platelets \ 1.5; discontinuation of antithrombotic drugs should follow the 2012 japanese guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment and the2017 appendix on anticoagulants including direct oral anticoagulants; * patients with severe electrolyte imbalances; * patients with acute peritonitis or suspected intestinal perforation; * patients with severe inflammatory bowel disease/toxic megacolon; * patients with polyposis syndromes (e.g., peutz-jeghers syndrome, cronkhite-canada syndrome, familial adenomatous polyposis \[fap\], lynch syndrome, etc.); * patients with stage 3 or higher hypertension (systolic blood pressure ≥180 mmhg or diastolic blood pressure ≥110 mmhg); * patients with untreated severe abdominal hernia, intestinal obstruction, or advanced colorectal cancer; * patients with intestinal strictures of any cause; * cases requiring only endoscopic submucosal dissection (esd); * pregnancy and lactation.

Keywords: three dimension imaging device colorectal polyps colorectal adenomas
the ideal-pci extended registry

Conditions: Coronary Arterioscleroses; Platelet Dysfunction Due to Drugs

Summary: the purpose of this study is to determine the efficacy and safety of a routine individualized antiplatelet therapy after coronary stent implantation by evaluating "on-treatment" platelet reactivity with multiple electrode aggregometry (mea, multiplate® analyzer). ideal-pci extended is the continuation of the ideal-pci registry with additional focus on bleeding events and net clinical benefit

determination of platelet reactivity in patients with percutaneous coronary intervention as described in the ideal-pci registry. in the ideal-pci extended registry an additional deescalation arm with reduction of the standard dual antiplatelet therapy (dapt) dosis in case of low platelet reactivity to p2y12 inhibition or aspirin with or without bleeding is implemented.

Eligibility criteria:
inclusion criteria: * all consecutive pci patients exclusion criteria: * pregnancy
virtual reality-training in theory of mind in the childhood form of myotonic dystrophy type 1

Conditions: Myotonic Dystrophy Type 1

Summary: the ability of an individual to conceive some alternative representations and to behave in a flexible manner would emerge from preschool age and drastically improve between the ages of 3 and 5 (doebel and zelazo, 2013). they constitute, according to diamond (2013), a prerequisite for the development of the theory of mind (tom). deficits in executive functions (ef) may therefore interfere with the child's ability to understand and adapt to social situations. treatment failures are often observed when traditional cognitive tools are used. this would be linked to the divergence between non-immersive tests and situations encountered in everyday life (damasio, 1994; priore castelnuovo and liccione, 2002). for this reason, an increasing number of researchers are using virtual reality for the rehabilitation of executive functions and theory of mind in patients with neurodevelopmental pathology (millen, edlin-white and cobb, 2010) or brain damage (le gall, besnard, louisy, richard and allain 2008). there is currently no systematic evaluation of tom in children with the infantile form of dm1 even though these abilities are considered particularly vulnerable and have a decisive impact on the subsequent development of interpersonal relationships. this research will focus on studying the socio-emotional disorders associated with the infantile form of myotonic dystrophy type 1 (dm1). the axis that we propose to develop more specifically will be an interventional study with the aim of remediation with children from 5 to 16 years old suffering from the infantile form of dm1 via a training protocol in low-immersion virtual reality (vr) centered on emotional processing and theory of mind.


Eligibility criteria:
inclusion criteria: * 6 years and \< 16 years of age * written informed consent * affiliate or beneficiary of a social security scheme * able to comply with all protocol requirements * infantile form of dm1 with molecular confirmation. * development without incident in the first year * normal development in the pre and neonatal period * native language french exclusion criteria: * unable to participate in the study * inability to comply with protocol requirements * congenital form of dm1 * iq\<70 (intellectual disability)

Keywords: myotonic dystrophy type 1 theory of mind virtual environment training protocol
graded activity training and task- oriented training on post-stroke fatigue

Conditions: Post-Stroke Fatigue

Summary: the aim of this randomized controlled trial is to determine the effects of graded activity training and task oriented training on fatigue in post-stroke patients. until now there is very limited work found on fatigue so this will increase quality of life in stroke patients and potentially reduce burden on healthcare system.

post stroke fatigue (psf) is one of the most common outcomes of stroke. psf is defined as "overwhelming feeling of exhaustion or tiredness" as a result of stroke psf is an undesirable outcome by which patient's ability in study participation, adherence to medication and effectiveness of rehabilitation decrease which is unrelated to exertion, and does not typically improve with rest. prevalence rate of psf ranges between 25% and 85% one out of two stroke survivors experience post-stroke fatigue. the relationship between physical deconditioning and fatigue is bidirectional there was a negative relationship between fatigue and aerobic fitness in chronic stroke. psf may arise from physical deconditioning (physical fatigue). therefore, improving physical endurance through physical activity training could potentially reduce fatigue complaints. the rationale of this study is to determine how task-oriented training and graded activity training effect stroke patient's levels of fatigue and to develop an improved fatigue management intervention protocol. this study will also determine effects of how both interventions affect mobility and gait. by doing so, we can identify a more effective psf intervention plan, which will help reduce the burden on the healthcare system and will lessen strain on caregivers and in turn enhance patient quality of life.

Eligibility criteria:
inclusion criteria: * both male and female of age 40 to 60 years. * patient with both ischemic or hemorrhagic stroke. * patient with both right and left hemiplegia. * checklist individual (cis-f) fatigue score of 40 or more. * patients who had sustained a stroke more than 4 months before recruitment. * patients who can independently walk for 10 meters (about 33 feets) exclusion criteria: * patients with severe comorbid health conditions (such as cardiac diseases, pulmonary diseases like copd, orthopedic conditions arthritis, joint replacements). * patients with uncontrolled diabetes, hypertension, depression and anxiety. * patients who are not willing to participate. * patient with any medications that can affect their ability to engage in physical training program like antidepressants, beta-blockers, corticosteroids etc. * pregnant women.

Keywords: task oriented training graded activity training post stroke fatigue
study on effects of bms-955176 on the pharmacokinetics of probe substrates

Conditions: HIV Infections

Summary: the purpose of the study is to study the effects of bms-955176 on the single-dose pk parameters of probe substrates caffeine, metoprolol, montelukast, flurbiprofen, omeprazole, midazolam, digoxin, and pravastatin


Eligibility criteria:
inclusion criteria: 1. written informed consent 2. healthy male and female (not of childbearing potential) subjects as determined by medical history, surgical history, physical examination, vital signs, ecgs, and clinical laboratory determinations 3. body mass index (bmi) of 18.0 kg/m2 to 32.0 kg/m2, inclusive, at screening and day 1. bmi = weight (kg)/\[height(m)\] 4. women must have documented proof that they are not of childbearing potential (eg, surgically sterile, postmenopausal with a documented follicle-stimulating hormone (fsh) \> 40 miu/ml) and should not be breast feeding 5. males who are sexually active with wocbp must agree to follow instructions for method(s) of contraception for the duration of treatment with bms-955176 in addition to a post-treatment completion period exclusion criteria: 1. any significant acute or chronic medical illness 2. use of tobacco, excessive alcohol 3. medical history indicative of an increased risk of a cardiac arrhythmia or cardiac disease and history of asthma, bronchospasm, sleep apnea, rhabdomyolysis, a bleeding disorder, a major depressive disorder within the past 6 months, peptic ulcer or significant gi bleed, raynaud's disease, or any gastrointestinal surgery that could impact upon the absorption of study drug 4. evidence of organ dysfunction or any clinically significant deviation from normal in physical examination, vital signs, ecg, or clinical laboratory determinations beyond what is consistent with the target population 5. history of allergy to bms-955176, digoxin (or any member of the digitalis glycosides class of drugs), caffeine, metoprolol, montelukast, flurbiprofen, omeprazole, midazolam, or pravastatin, or to any related compounds
the effect of artificial intelligence-assisted visual case analysis on nursing students' knowledge and attitudes towards pressure injury prevention: a single-blind randomized controlled trial

Conditions: Artificial Intelligence (AI); Visual Case Analysis; Nursing Students; Pressure Injury Prevention; A Single-blind Randomized Controlled Trial

Summary: the goal of this clinical trial is to examine the effect of artificial intelligence-assisted visual case analysis on nursing students' knowledge and attitudes towards pressure injury prevention. the main hypotheses it aims to answer are: * ai-assisted visual case analysis affects nursing students' knowledge about pressure injury prevention. * ai-assisted visual case analysis affects nursing students' attitudes toward pressure injury prevention. researchers will compare ai-assisted case analysis to conventional case analysis to see if it affected nursing students' knowledge and attitudes about pressure injury prevention. participants, * the case group will shown an ai-supported presentation explaining the pressure injury prevention case. the control group will given a classic case analysis. * at the end of the case, the pupkai and apup scales will administered to the students in written form in the classroom.


Eligibility criteria:
inclusion criteria: * taking the fundamentals of nursing ii course for the first time * not working as a nurse in a health institution. * volunteering to participate in the study. exclusion criteria: * having previously received patient pressure injury prevention training; * having repeated the fundamentals of nursing ii course; * having difficulty speaking and understanding turkish; * exceeding the course attendance time * not attending pressure injury prevention training and evaluation * filling in incomplete data * graduating from a health-related high school or university.

Keywords: ai-assisted visual case analysis nursing students artificial intelligence (ai) pressure injury prevention randomized controlled trial
purse string suture for the closure of large thyroidectomy resulted in better cosmetics

Conditions: Thyroidectomy

Summary: thyroidectomy for large thyroid tumor poses a problem of cosmetics, especially in terms of wide post-operative scar and prominent neck wrinkles. in this manuscript, we performed purse-string suture for the first time for the closure of skin defect after thyroidectomy of large thyroid tumors which resulted in better cosmetics as compared to the conventional suturing method.

increasing demand for better cosmetics following thyroidectomy for large thyroid tumor of \> 6 cm diameter created a necessity to find an alternative to the conventional technique (ct), which could be addressed by purse string technique (pst). a non-randomized controlled trial was conducted to new thyroid tumor patients at cipto mangunkusumo hospital (rscm) from october 2013 until december 2014. thirty patients grouped into two intervention arms of thyroidectomy with pst and ct were assessed for post-operative scar outcomes.

Eligibility criteria:
inclusion criteria: * new cases of thyroid tumor in doctor cipto mangunkusumo general hospital * tumor diameter \> 6 cm exclusion criteria: * previous surgery in the anterior neck area * local involvement of lymph nodes requiring nodes dissection

Keywords: large thyroid purse string suture thyroidectomy
dietary intervention of stress-induced neurovegetative disorders with a specific amino acid composition (asn01)

Conditions: Nervous System Disorder; Imbalance of Constituents of Food Intake

Summary: psychosocial stress leads to altered neuroendocrine functions, such as serotonergic dysfunction, as well as alterations of the autonomic nervous system and the hypothalamic-pituitary-adrenal (hpa) axis activity resulting in an imbalance between inhibitory and excitatory neurotransmitters. clinical consequences include, inter alia, neurovegetative disorders, higher resting heart rate, hypertension, depressive symptoms, sleep disturbances, irregular body-weight changes, and insulin resistance. poor dietary intake of the essential amino acid l-tryptophane as a precursor to 5-hydroxytryptamine (ht, serotonin) increases sensitivity to stress. it is therefore the investigators hypothesis that daily oral administration of an amino acid mixture (dosage 3.8 g/day) with micronutrients specifically designed to decrease neurovegetative disorders will target these neuroendocrine and metabolic alterations in adults with psychosocial stress. the principal endpoints will be a decrease in points in the psychological-neurological questionnaire (pnf).


Eligibility criteria:
inclusion criteria: * age: 18-65 years * psychological-neurological questionnaire (pnf): 30 - 50 points exclusion criteria: * age: \ 65 years * psychological neurological questionnaire (pnf): \ 50 points * resting heart rate: \< 70/min * supplementation with dietary supplements or drugs which contains amino acids, vitamins and other micronutrients * therapy with antipsychotic drugs such as tranquilizer, antidepressants * acute and chronic diarrhea * psychological-neurological or psychiatric therapy

Keywords: stress lability and irritative disturbances dietary supplement amino acid composition psychological neurological questionnaire (pnf)