Kornimate/medical-research-clean huggingface dataset:
biomarkers of pediatric heart failure

Conditions: Heart Failure

Summary: heart failure (hf) is a clinical syndrome where the heart is unable to pump the blood required to meet the metabolic demands of the body. heart failure in children can result from a variety of structural or functional cardiac disorders with subsequent failure of the ventricles to fill with or eject blood

cardiac biomarkers are useful as diagnostic and prognostic tools, especially in patients with atypical signs and symptoms. high rate of complication in hf led to the search for suitable cardiac biomarker that diagnose heart failure as early as possible, predict outcome, reflect response to treatment and help in staging of heart failure and determine risk (6) . in pediatrics, biomarkers of heart failure are particularly important for the early identification and risk stratification of patients with systemic diseases and associated risk for early development of heart failure. good biomarkers have the following characteristics: high sensitivity and specificity, the possibility of simultaneous processing of many samples, short analysis time, low cost, and good clinical applications, thus predicting the risk of heart failure and the associated prognosis as well as the adequacy of monitoring \[7\]. . neutrophil gelatinase-associated lipocalin (ngal) is a 25 kda protein covalently bound to matrix metalloproteinase-9 which was first isolated from neutrophils. it belongs to the lipocalin family, ngal has been found to be elevated in both plasma and urine in patients with hf.(8) ngal also acts as a growth and differentiation factor in the renal epithelium \[9\].

Eligibility criteria:
inclusion criteria children from 1 month to 16 years old admitted to assiut children university hospital the pediatric cardiology unit with clinical manifestation of heart failure according to ross classification either due to congenital or due to acquired heart disease will be enrolled in the study exclusion criteria children with renal disease or failure, hepatic disease, pulmonary diseases will also excluded.
comparison of trelstar versus lupron or zoladex in advanced prostate cancer

Conditions: Prostate Cancer

Summary: this research study looks at testosterone levels in patients receiving trelstar versus those receiving lupron or zoladex. these drugs have been approved for treatment of prostate cancer by the fda.

patients who are currently receiving lupron or zoladex will be consented and then randomized to receive either continued treatment with the drug they have been on, or will be randomized to trelstar for a period of 3 months. at the end of that period, testosterone and prostate serum antigen (psa) levels will be drawn and compared to their previous levels to determine if trelstar is as effective as the previous treatment.

Eligibility criteria:
inclusion criteria: * advanced prostate cancer * currently taking lupron or zoladex * stable psa * baseline testosterone below castration level * life expectancy \> 6 months * eastern cooperative oncology group performance status of 0-2 * signed, approved informed consent. exclusion criteria: * known hypersensitivity to any leuteinizing hormone releasing hormone (lhrh) agonist * ongoing therapy with hyperprolactinemic agents * antiandrogen therapy within 28 days prior to study start * prior orchiectomy, hypophysectomy or adrenalectomy * chemotherapy, radiotherapy, or prostatectomy within 28 days prior to study start * use of any investigational agent 3 months prior to enrollment * use of systemic corticosteroids within 28 days or during study * other malignancies within 2 yrs prior to study start, except curatively treated skin cancers * severe kidney or liver failure, based on adequate lab values * other medical conditions which would be likely to interfere with compliance or completion of study requirements

Keywords: prostate cancer trelstar
spinal or general anesthesia for umblical hernia surgery

Conditions: Umbilical Hernia; Spinal Aneshtesia; General Anesthesia

Summary: in this study, the investigators compared spinal anesthesia under ketofol (ketamine-propofol combination) sedation with general anesthesia in terms of intraoperative and postoperative hemodynamics, respiratory parameters and cost in patients undergoing umbilical hernia operation. the investigator aimed to provide the most appropriate and hemodynamically stable option for the patient, to decrease the complication rates and to reduce the associated costs.

this study was carried out at the ministry of health ankara city hospital operating room, after receiving ethics committee approval.preoperative evaluation was performed before the operation in cases undergoing elective umbilical hernia surgery.complications and side effects are explained in detail.verbal and written consents were obtained from the subjects who agreed to participate in the study.in patients undergoing umbilical hernia surgery, general anesthesia and spinal anesthesia under propofol and ketamine (ketamine-propofol combination) sedation were compared in terms of intraoperative and postoperative hemodynamics, aldrete score, pain score, respiratory parameters, and cost. the patients, who had fasted for 8 hours before the operation, were taken to the operating room without premedication. in all cases, a peripheral venous catheter cannulated on the dorsal part of the hand (20g, plusflon i.v. cannula, india) .standard monitoring was applied. group1. as premedication 0.03mg/kg midazolam was administered . for spinal anesthesia, 15 mg heavy-bupivacaine, sedation was provided with ketofol. ketamine:propofol mixture was prepared as 1:1 5mg/ml propofol and 5mg/ml ketamine 1 mg/kg ketofol administered i.v. group2 . as premedication 0.03mg/kg midazolam was administered.in general anesthesia to all patients after induction 3 mg/kg propofol, 0.6 mg/kg rocuronium and 1 mcg/kg fentanyl bispectral index and non-invasive blood pressure was monitored, a urinary catheter was placed. anesthesia was maintained with sevoflurane and fentanyl to keep bis values between 40-60.

Eligibility criteria:
inclusion criteria: * asa i-ii patients between the ages of 18 and 65 who would undergo umbilical hernia surgery were included in the study. exclusion criteria: * who do not accept the procedure * serious cardiovasculer disease ,renal, hematological (bleeding diathesis, under anticoagulant therapy, those with hemoglobin value below 10 g/dl) disease, hepatic disease, cerebrovascular, neurological or psychiatric diseases, * those who are contraindicated for spinal anesthesia, * those who are allergic to one of the local anesthetics to be used, with drug and alcohol addiction, * pregnant or breastfeeding * using drugs and analgesics effective on the central nervous system were excluded from the study.
changes of the peripapillary retinal nerve fiber layer after filtration surgery in glaucoma patients

Conditions: Nerve Fiber Bundle Defect; Optic Nerve Diseases

Summary: at present, trabeculectomy is the most common performed and effective surgical method of filtration surgery for patients with medically uncontrolled glaucoma. the aim of this prospective observational case study is to determine changes of the peripapillary retinal nerve fiber layer thickness using spectral domain optical coherence tomography in patients with glaucoma after surgical reduction of intraocular pressure.

baseline and postoperative measurement of the peripapillary retinal nerve fiber layer (rnfl) thickness will be performed using the following spectral domain optical coherence tomography (oct): cirrus™ hd-oct (carl zeiss meditec) and spectralis® heidelberg-engineering. the main outcome measures will be changes in overall and quadrant rnfl thickness with respect to reduction in intraocular pressure (iop), correlation between rnfl thickness and alteration in visual field and predictive factors of postoperative iop-reduction and changes of rnfl thickness.

Eligibility criteria:
inclusion criteria: * primary or secondary open angle glaucoma * target intraocular pressure under medical treatment was not reached * progression of visual loss * best corrected visual acuity of 20/100 or more * spherical equivalent refraction of -8.0 to +4.0 d * perimetry: less than 20% false positive answers exclusion criteria: * primary or secondary angle closure glaucoma * congenital glaucoma * normal tension glaucoma * neovascular glaucoma
pediatric anxiety intervention with an entertaining video game: feasibility study

Conditions: Anxiety

Summary: this research study aims to test the feasibility and effectiveness of using an entertaining video game as an addition to traditional therapy for the treatment of anxiety disorders in youth, particularly those youth who may have limited access to mental health treatment in the traditional clinical setting.

the purpose of this research is to learn whether or not youth with social anxiety find a therapeutic video game engaging and useful. children between the ages of 7 \& 17 who have been diagnosed with a social anxiety disorder will be invited to participate in this study.

Eligibility criteria:
inclusion criteria: 1. age 7 to 17 2. primary diagnosis of: 1. social phobia, 2. separation anxiety disorder 3. a parent or other primary care giver available to participate with the child in all assessment and treatment activities 4. estimated average intelligence 5. english speaking 6. received les than 3 treatment sessions for social anxiety disorder exclusion criteria: 1. history of and/or current diagnosis of: 1. psychosis, 2. autism, 3. bipolar disorder, 4. mental retardation, 5. oppositional defiant disorder, 6. ptsd, 7. selective mutism, or 8. major depressive disorder 2. current suicidality or recent suicidal behavior 3. parent to be involved in study who is unable to adequately participate due to intellectual or psychiatric difficulties 4. starting or changing the dosage of a psychiatric medication in the last two months

Keywords: anxiety social phobia separation anxiety generalized anxiety gad phobia video game teen youth child adolescent
cervical interlaminar versus transforaminal epidural steroid injection

Conditions: Cervical Radiculopathy

Summary: compare cervical interlaminar epidural injection of betamethasone (9mg) and cervical transforaminal epidural injection of dexamethasone (15 mg) for cervical radicular pain

this study will compare one route of epidural steroid injection (interlaminar) using a particulate steroid to another route of epidural steroid injection (transforaminal) using a different non-particulate steroid dexamethasone. repeat injections may be allowed. all injections will be done with image guidance. patients will be evaluated for improvements in pain and function.

Eligibility criteria:
inclusion criteria: * - aged \>18, capable of understanding and providing consent in english, capable of complying with the outcome instruments used, capable of attending all planned follow up visits * unilateral cervical radicular pain as defined by arm pain or shoulder girdle pain/periscapular pain with or without neck pain of at least 2 weeks. * 7 day average of numeric pain rating score (nprs) for arm pain or shoulder girdle/periscapular pain of at least 5/10 at baseline evaluation * mri (or ct if mri not available) shows one or two level cervical disc herniation(s) or disc osteophyte complex(es) between levels c4-t1, corresponding in location with unilateral radicular pain, with or without neurological deficits. mri or ct may show degenerative changes at other levels. * patient consents to treatment with epidural injection in a shared decision-making process with the treating physician. * pain duration of at least 2 weeks or more. exclusion criteria: * - neck pain is greater than arm pain or shoulder girdle/periscapular pain based on 7 day average nprs * those receiving remuneration for their pain treatment (e.g., disability, worker's compensation). * those involved in active litigation relevant to their pain. * those unable to read english and complete the assessment instruments. * those unable to attend follow up appointments * the patient is incarcerated. * spondylolisthesis at the involved or adjacent segments. * history of prior cervical surgery * progressive motor deficit, and/or clinical signs of myelopathy. * prior cervical epidural steroid injections. * prior epidural steroid injection within the prior 12 months in any location within the spine. * possible pregnancy or other reason that precludes the use of fluoroscopy. * allergy to contrast media or local anesthetics. * bmi\>35. * systemic inflammatory arthritis (e.g., rheumatoid arthritis, ankylosing spondylitis, lupus). * active infection or treatment of infection with antibiotics within the past 7 days. * medical conditions causing significant functional disability (e.g., stroke, copd) * chronic widespread pain or somatoform disorder (e.g. fibromyalgia). * addictive behavior, severe clinical depression, or psychotic features.
labor analgesia in the latent phrase

Conditions: Labor Pain

Summary: painless labor is an essential part in woman's health care. labor analgesia in the active phrase is in popular use currently. however, parturients are still haunted by the labor delivery pain in the latent phrase up to 7-8 hours, especially for the nulliparas. therefore, we hypothesized that labor analgesia in the latent phrase of the first delivery stage would provide superior health care for laboring women. in addition, such analgesia technique would not prolong the time of uterine dilation and labor delivering.


Eligibility criteria:
inclusion criteria: * nulliparas * required labor analgesia * chinese. exclusion criteria: * allergic to opioids and/or local anesthetics * failed to performing epidural catheterization * organic dysfunction * contraindications for epidural analgesia.

Keywords: epidural analgesia latent analgesia active analgesia labor delivery
effects of visual reconstruction on brain function and structure in children with congenital cataract

Conditions: Congenital Cataracts

Summary: children have considerable plasticity of the visual system during the formation and maturation of various visual functions at different ages. congenital cataracts are the leading cause of treatable blindness in children. with the continuous improvement of surgical approaches and surgical techniques, the success rate of congenital cataract surgery has been significantly improved clinically, and the visual function of children has been significantly improved after surgery. however, to date, there has been no experimental study of specific changes in the brain before and after surgery in children with congenital cataracts to explore its relationship with visual reconstruction. we aim to investigate the effects of congenital cataract surgery on the brain function and structure of children through preoperative and postoperative analysis and comparison of brain imaging such as bold-fmri and dti, and provide new ideas for the clinical treatment and prognostic assessment of this disease.


Eligibility criteria:
inclusion criteria: * children with congenital cataracts exclusion criteria: * other oculo-cerebral and systemic diseases that may affect the outcome
the impact of the birth of a child with a rare abdomino-thoracic malformation

Conditions: Congenital Malformation

Summary: qualitative study in psychology whose main objective is to propose a grounded theory to report the dynamics of parental adjustment for the period from the announcement of the diagnosis to one year of the child affected by a rare thoracic abdominal congenital malformation, requiring neonatal surgery.


Eligibility criteria:
inclusion criteria: * to be the parent of a child aged 12 to 36 months old having undergone neonatal surgery following oesophageal atresia, congenital diaphragmatic hernia or short bowel syndrome diagnosis. * to have lived with the child during his first year of life * to have social security coverage * to speak french exclusion criteria: * to be a person not having the capacity to consent or enjoying social protection (tutorship or guardianship); * to be a person deprived of liberty; * to be a minor; * to be pregnant.

Keywords: oesophageal atresia congenital diaphragmatic hernia short bowel syndrome
consequences of hypoglycemia on intensive care unit (icu) patients

Conditions: Critical Illness

Summary: hypoglycemia occurs frequently during intensive blood glucose control in critically ill patients. the incidence of hypoglycaemia is associated with impaired outcome. however, it is hitherto unknown if hypoglycaemia itself predisposes patients to neurological impairment, e.g. cognitive dysfunction, or if it is the underlying medical condition that makes the patient prone to a high risk of hypoglycaemia and, concomitantly, neurocognitive impairment. therefore we investigate neurocognitive function in patients who had hypoglycemias during their intensive care stay and compare the results to patients without hypoglycaemia whose medical conditions are matched to the hypoglycaemia patients.


Eligibility criteria:
inclusion criteria: * all patients exclusion criteria: * clinical diagnosis of diabetes mellitus * brain injury of any kind prior to or upon icu-admission * pre-existing mental or psychiatric disorder * terminal kidney or liver failure prior admission * drug abuse, * cpr \> 5 min * hiv * lues

Keywords: critical illness hypoglycemia neurocognitive dysfunction intensive insulin therapy
prophylaxis in venous thromboembolism in primary care, a pilot study

Conditions: Thromboembolism; Deep Vein Thrombosis; Dalteparin

Summary: the primary objective was to study the clinical benefit with dalteparin sodium in thromboprophylaxis in primary care medical subjects. the secondary objective was a pharmacoeconomic evaluation of hromboprophylaxis with dalteparin sodium in primary care medical subjects.

the study was prematurely terminated on december 9, 2003. the reason for the early termination was not related to a safety or efficacy issue. it was related to the difficulty in recruiting patients.

Eligibility criteria:
inclusion criteria: * age \> 65 years * confinement to bed for more than 3 days, due to: * heart failure * exacerbated chronic obstructive pulmonary disease * acute rheumatic involvement * written informed consent exclusion criteria: 1. cancer 2. anticoagulant treatment in the previous 3 months 3. stroke or major surgery in the previous 3 months 4. systolic pressure \>200 mmhg or diastolic pressure \>120 mmhg 5. known chronic hepatopathy 6. active hemorrhage in any site in the previous 3 months 7. active peptic ulcer 8. bacterial endocarditis 9. conditions that can increase the risk of hemorrhage 10. known coagulation disorders 11. hypersensitivity to heparin or hit 12. life expectancy of less than 3 months 13. previous confinement to bed during more than 3 days
effects of masseter manual therapy on temporomandibular dysfunction

Conditions: Temporomandibular Joint; Temporomandibular Joint Dysfunction Syndrome; Temporomandibular Joint Disorder

Summary: muscles and myofascial dysfunction are more often the mechanism and source of pain in oral fascial disorders (ofd) than the tmj. masticatory muscles in patients with tmj alterations are more hypertonic, less efficient and more prone to fatigue compared to age and sex matched controls. it is our opinion that active release technique can be a reliable assessment and treatment tool in the resolution in cervical-cranio mandibular disorders. our goal is to improve masticatory function through treatment of trigger points in the masseter.

recruit 45 patients with tmd determined by questionnaire. measure pre and post mandibular active range of motion and vas pain scale. treatment will include 4 visits over a two week span measuring before first treatment and after last treatment. there will be 3 treatment groups; active release technique, post isometric relaxation and a no treatment control group. we will analyze data for any change in mandibular range of motion and vas pain scale.

Eligibility criteria:
inclusion criteria: * difficulty and/or pain when opening mouth * jaw locking * difficulty or pain when chewing or talking * tmj clicking * jaw stiffness, tightness, or fatigue * pain in ear, temple or cheeks * frequent headaches, neckaches, toothaches * change in occlusion exclusion criteria: * trauma to head, neck or jaw within last 12 months * recent dental extractions * taking prescription analgesics/muscle relaxants * recent cervical smt (hvla) * already under care for condition * sinus infection
sex-specific association with kidney disease

Conditions: Diabetic Nephropathy

Summary: oxidative stress is involved in the pathophysiology of diabetic nephropathy. the superoxide-generating nicotinamide adenine dinucleotide phosphate-oxidase 2 (nox2, encoded by the cybb gene) and the antioxidant enzyme glutathione peroxidase 4 (gpx4) play opposing roles in the balance of cellular redox status. in the present study, we investigated associations of single nucleotide polymorphisms (snps) in the regulatory regions of cybb and gpx4 with kidney disease in patients with type 1 diabetes.

in the present study, three cohorts of type 1 diabetic patients (one brazilian and two french/belgium cohorts) were studied for the association with diabetic nephropathy (dn) with a total of 1396 patients. the patients were classified according to the urinary albumin-to-creatinine ratio (acr) or urinary albumin excretion rate (uaer) in absence of nephropathy, defined as acr \ 300 mg/g of creatinine or uaer \>200 µg/min or \> 200 mg/l) and plasma creatinine \ 1.7 mg/dl and any renal replacement therapy. genotyping of polymorphisms was performed by real time pcr using fluorescent-labelled probes.

Eligibility criteria:
inclusion criteria: * overt 10 years of diabetes mellitus (brazilian cohort) * diagnostic of diabetes before the age of 35 years, with initial ketosis and requirement for permanent insulin treatment within 1 year of diagnosis and past or present diagnosis of diabetic retinopathy. (genesis cohort). * diagnostic of diabetes before the age of 35 years and past or present diagnosis of severe diabetic retinopathy. (genediab cohort). exclusion criteria: * patients presenting autoimmune diseases, hiv or hcv infections (brazilian cohort) * patients with glomerular filtration rate \< 60 ml min-1 1.73 m2 without diabetic retinopathy (brazilian cohort) * terminal cancer and personal disability (genediab cohort).

Keywords: oxidative stress genetic susceptibility gpx4 nox2
efficacy of pragmatic same-day covid-19 ring prophylaxis for adult individuals exposed to sars-cov-2 in switzerland

Conditions: Prevention of COVID-19

Summary: a study to assess, in a two-arm open-label cluster randomized clinical trial, the efficacy of a 5-day course of lpv/r treatment in preventing covid-19 in asymptomatic individuals exposed to a sars-cov-2 documented index patient, compared to surveillance alone.


Eligibility criteria:
inclusion criteria: 1. documented close contact with a person with either a pcr-confirmed sars-cov-2 or a positive rapid sars-cov-2 antigen test (as per standard of care). 2. enrolment of the participant no more than 7 days since last contact with index case; 3. ≥ 16 years of age; 4. informed consent as documented by signature (including parent's or legal guardian's signature if the participant is between 16 and 18 y.o.). exclusion criteria\*: 1. fever (temperature \>38.0°c) and/or respiratory symptoms (cough, dyspnea) and/or new anosmia/ageusia; 2. individuals with previous confirmed sars-cov-2 infection, dating within the last six months ; 3. known impairment of liver function; 4. known hypersensitivity to the study medications; 5. use of any medications that are contraindicated with lopinavir/ritonavir using the website www.hiv-druginteractions.org/checker 6. individuals on boosted protease inhibitor (other than lpv) or boosted elvitegravir as part of an antiretroviral therapy 7. inability to be followed-up for the trial period 8. documented vaccination against sars-cov-2 * where necessary, additional biological and clinical assessment will be performed, based on clinical judgement.

Keywords: covid-19