Kornimate/medical-research-clean huggingface dataset:
gastrointestinal surgery study group 2001

Conditions: Gastrostomy; Computed Tomography Angiography; Clinical Outcome

Summary: gastric cancer is one of the most common malignace worldwide, which caused a dramatically death rate, especially in east asian, such as japan , south korea and china. although the treatment of gastric cancer has a large improvement, such as radiotherapy, chemotherapy and immunotherapy, surgery is yet the mainstream method for the curable malignace without distant metastasis. as the innovation of treatment in gastric caner, laprascopic has gain its popularity owing to its equivalent oncologic outcomes, earlier oral feeding, shorten postopertative of hospital length,compared with open surgery. depite it has several advantages, the defect of laparascopic surgery is still obvious, such as 2d surgical field, lack of inverse haptic feedback, inflexible equipment. d2 lymph node dissection associated with laparascopic gastronomy is still regard as standard surgical procedure for the gastric cancer patient whose tumor stage was evaluated in advance stage. as we known that the distribution of lymph nod is accompanied with blood vessels, even for well-trained surgeon, the procedure lymph node dissection is a challenging and tough work. computed tomography angiography(3d-cta), as a emerging technology, is gradually receive the surgeon's attention for its remedy characteristic to the defect of laparascopic surgery, which can visually display the distribution and type of perigastric artery, resulting in decresing the difficulty and risk of surgery. the aim of the study is to investigate the clinincal outcomes for the patient with bmi ≥25 kg/㎡who underwent laparascopic or robotic gastronomy using cta to evaluate the type of perigastric artery.


Eligibility criteria:
inclusion criteria: 1. pathological diagnosis of gastric adenocarcinoma by gastroscopy 2. age 18\~75 years old 3. bmi≥25.0kg/m2 4. preoperative imaging staging is t1\~t4a, n0\~3, m0 5. the surgical approach is laparoscopic surgery and robotic surgery exclusion criteria: 1. patients whose tumors stage are found to be t4b or m1 during the operation, tumors are unresectable and accompanied with malignant tumors in other parts; 2. suffering from other malignant tumors, tumors of low malignant potential (giant cell tumor of bone, pseudomyxadenoma of appendix, invasive fibroma) in the past; 3. patients who have serious other system diseases and cannot tolerate surgery; 4. patients with non-adenocarcinoma type malignant tumors in pathology after surgery; 5. patients with residual gastric cancer; 6. those who are allergic to iodine contrast agents; 7. those who have received neoadjuvant therapy before surgery; 8. pregnant patients; 9. patients who are participating in other clinical studies trial.
the role of biomarkers in the occurrence and development of asthma

Conditions: Asthma in Children

Summary: to study the expression level of biomarkers such as gitrl in peripheral blood of children with asthma and analyze their correlation with the severity of asthma. to study the predictive value of biomarkers level for the occurrence and development of asthma. and to provide supplementary detection means and predictive indicators for the diagnosis of asthma and the severity of asthma.

recruit 30 children with asthma and 30 healthy children based on the consent of the children and their parents or their guardian. collect and record general information such as name, age, time of first diagnosis, allergens or triggers, daily dosage and frequency of asthma control drugs, home address and contact information. collect 5 ml of blood sample for the detect of the biomarkers. asthma severity was assessed using pulmonary function by spirometry and score of c-cat. finally study the correlation between the level of biomarkers and asthma severity and the role of biomarkers in the occurrence and development of asthma.

Eligibility criteria:
inclusion criteria: * in line with the diagnostic criteria in the guidelines for the diagnosis and prevention of bronchial asthma in children (2016 edition) * age: 4-12 years old for new diagnosis or recurrent episodes * typical clinical manifestations and complete clinical data * family members or guardians of children with informed research and signed consent * all healthy control subjects had no history of lung disease, allergic rhinitis or any other atopic disease exclusion criteria: * suffering from other respiratory diseases (such as bronchiectasis, allergic rhinitis, respiratory failure, tuberculosis, obstructive airway disease) or other inflammatory diseases. * abnormal development of congenital airway and lung tissue * history of immunosuppressant or glucocorticoid use in the first 4 weeks * suffering from other endocrine system and immune system diseases * incomplete clinical data or examinations.

Keywords: asthma children biomarkers
splenic surgery for hydatid spleen in single institutional experience

Conditions: Spleen; Cyst, Hydatid (Manifestation)

Summary: splenic-preserving surgery in hydatid spleen: single intuitional experience

background: although hydatid disease affects many organs in the human body, splenic hydatid represents about 0.8-4% of all human echinococcosis cases. until recently, splenectomy was the recommended surgical procedure for splenic hydatid. since 1980 there has been an increasing tendency to use conservative option to deal with such pathology. aim of the study: to evaluate our experience in open splenic-preserving surgery for splenic hydatid in a single institutional study. patient and methods: a retrospective study. ten patients with splenic hydatid were operated upon from august 2013 to january 2018 in our medical centre. spleen has affected alone in 7 cases, liver and spleen were affected in 3 cases, and one of them had intraperitoneal cyst affection in addition. the diagnosis confirmed mainly by ultrasonography. in some cases, it computed tomography ct scan, and magnetic resonance imaging mri were needed. chest x-ray had taken for all patients to exclude pulmonary hydatid. the open surgical procedure used. isolation of the field, aspiration of cystic fluid and injection of 1% cetrimide solution, re-aspiration, endocystectomy, suturing of cystic edges over intracystic tube drain. all surgery did under cover of albendazole pre and postoperative 15mg/kg/day. results: no significant intraoperative and postoperative complications. no reoperation was needed. hospital stays 3-5 days. no recurrence after (1-3) year follow-up. however, three patients missed follow-up after two years. conclusion: our experience in splenic hydatid encourages us to use splenic-preserving surgery whenever possible instead of splenectomy.

Eligibility criteria:
inclusion criteria: single hydatid spleen primary spleen hydatid - exclusion criteria: * multiple splenic hydatid rupture hydatid spleen

Keywords: spleen hydatid cyst surgery preserving surgery
prevalence of fgids and probiotics study

Conditions: Functional Gastrointestinal Disorders; Infant Conditions

Summary: this is a study to evaluate the prevalence of fgids in infants using the thai version of rome iv diagnostic questionnaire for functional gastrointestinal disorders in infants and evaluate the efficacy of limosilactobacillus reuteri dsm 17938 to prevent fgids in infants.

this is a randomized controlled trial study about the the efficacy of lactobacillus reuteri dsm 1987 to prevent fgids in healthy infants and the effect to gut microbiota diversity. the incidence of fgids in thai infant using thai version of rome iv questionnaire (authorized by rome foundation) for infant and toddler and the associated factors of fgids also evaluate. population: target and control populations are the healthy infants born at king chulalongkorn memorial hospital, bangkok, thailand, and can come to follow up at the hospital at 1, 2, 4, and 12 months of age inclusion criteria 1. healthy and term (ga 37-41 weeks) infants 2. appropriate weight for age 3. apgar score more than 8 at 10 minutes of life 4. normal physical examination 5. mothers have no previous probiotics use methodology * participants were double-blinded randomized using computer generation in block of four * target population were received limosilactobacillus reuteri dsm 17938 5 drops (0.185 ml) per day for 60 days * control population were received mixture of sunflower oil and mct oil 5 drop (0.185 ml) per day for 60 days * there were 5 visits at birth, 1, 2, 4, 12 months of life: the demographic data/rome iv questionnaire for fgids in infant and associated factors with fgids record, physical examination and stool collection * research assistance will telephone to them to take the rome iv questionnaire for fgids at 3, 6, 9 months of life biological specimen collection stool will be collected by rectal stimulation in each visit. the amount of \>5 gm stool will be preserved in dna and kept at -80 °c. all stool specimen will be processed the dna extraction (dna \> 40 microlitre with concentration \>50 ng/l). the dna extraction for further amplification 16s rrna using illumina. the rest of the specimen will be kept up to 10 years for further evaluation.

Eligibility criteria:
inclusion criteria: 1. healthy and term (ga 37-41 weeks) infants 2. appropriate weight for age 3. apgar score more than 8 at 10 minutes of life 4. normal physical examination 5. mothers have no previous probiotics use exclusion criteria: 1. not willing to anticipate in the study 2. cannot come to follow-up until 1 year of age

Keywords: functional gastrointestinal disorder colic regurgitation constipation infant prevalence
improving south african government workers' capacities to deliver hiv interventions

Conditions: HIV; Partner Violence; Malnutrition; Alcohol Use/Abuse; Depression

Summary: the purpose of this study is to address the united states office of aids research highest priorities: improving the workforce, reducing health disparities, and addressing hiv comorbidities. ucla will randomize the government-funded community health workers (chw) from 16 clinics in matched rural areas in the eastern cape in south africa to either: 1) the accountable condition (ac) in which additional monitoring and accountability systems that philani routinely uses are implemented or 2) a control condition (cc), of initial philani training, but ongoing supervision and monitoring consistent with local government practices.

each dollar invested in maternal, child health (mch) yields a nine-fold benefit. home visiting has been repeatedly demonstrated efficacious in improving mch outcomes, including when delivered by chw in low and middle income countries (lmic). however, when home visiting programs are scaled, they are not effective. africa has particular challenges with broad implementation of effective interventions often associated with the poorly trained and poorly monitored health personnel, in this case, chw who are perinatal home visitors. the investigators have shown that with training, supervision, and accountability, chw home visits are effective in a successful randomized controlled trial (rct) conducted in peri-urban townships in cape town, south africa. chw were trained to address hiv, alcohol, and malnutrition among all pregnant women in a neighborhood - to avoid stigma and to address multiple challenges concurrently. the visits significantly improved maternal and child outcomes over three years. based on these results, the philani intervention model served as one model for re-engineering primary health care for 65,000 chw in south africa. the mthatha provincial government has agreed for the philani program to train, monitor, and supervise their already-hired chw. this rct will evaluate whether routinely implementing training and monitoring chw behavior and mch outcomes with mobile phones, and providing data-informed supervision, will result in chw becoming more effective. stellenbosch university interviewers will independently assess outcomes of each mother at pregnancy, and of the mothers and infants within two weeks of post-birth, 6 months, 15 months, and 24 months later. the primary outcome will be maternal hiv/tb testing, linkage to care, treatment adherence and retention in medical regimens, depression, and parenting; and her child's physical growth, cognitive functioning, and behavior adjustment.

Eligibility criteria:
inclusion criteria: * mothers living in the catchment area * mothers not identified as psychotic or delusional based on the interviewer's judgment * mothers able to provide informed consent exclusion criteria: * inability to give informed consent * inability to converse with the interviewer or the chw * death of the mother or infant.

Keywords: pregnancy home healthcare visits community health workers infants
influence of tdcs on cortical plasticity in patients with dementia of the alzheimer type

Conditions: Dementia of Type Alzheimer

Summary: the aim of this study is to investigate whether the anodal transcranial direct current stimulation (tdcs) over the primary motor cortex (m1) in patients with dementia of the alzheimer type (dat) leads to an increase in cortical plasticity (change in motor evoked potentials (mep) in mv).


Eligibility criteria:
inclusion criteria: * right-handed according to the oldfield händigkeits inventory (lateralization index\> 70) (1971) * cognitive impairment, which corresponds to a mild to moderate dat * no treatment with ache inhibitors, or existing stable treatment with ache inhibitors for over 3 months * no motor impairments relevant to everyday life * age 50 to 80 years * existing insurance certificate * existing informed consent exclusion criteria: * severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected * epilepsy, epileptic seizure in medical history * cognitive deficit (mmse \<20) * depressive episode (beck depression inventory (bdi)\> 12) * intake of centrally active drugs \<3 months, particularly acetylcholinesterase inhibitors * pregnancy * pacemaker (contraindication for mri) * other metal parts in the body (contraindication for mri)

Keywords: cortical plasticity transcranial direct current stimulation
clinical outcome of lipiflow treatment prior to cataract surgery in dry eye patients

Conditions: Dry Eye

Summary: to investigate the clinical outcome of lipiflow treatment prior to cataract surgery in patients with meibomian gland dysfunction and dry eye disease


Eligibility criteria:
inclusion criteria: * patients older than 21, who will get catarct surgeyr * patients whose visual acuity anticipated better than 20/25 after surgery * patients with informed consent * patients with meibomian gland dysfunction exclusion criteria: * ocular injury, active injection * uncontrolled systemic disease * contact lens wear within 1 month * allergic to fluorescein sodium or topical anesthetics * ocular surgery or trauma within 6 months * disorder of lid anatomy * other reason for decreased vision other than cataract * anticipated visual acuity less than 20/25 * patients less than 20 years.
analysis of the virtual acute care at home experience

Conditions: Conditions; Infections; Heart Failure; Renal and Urinary Disorders; Diabetes; Hypertension; Fever; Bronchitis; Asthma, Chronic Obstructive Pulmonary Disease (COPD)

Summary: the purpose of this study is to examine the implementation, intervention effectiveness, and dissemination of a digital acute care delivery model for improving selected health outcomes in the hospital at home population.

the investigators will conduct a mixed-methods quasi-experimental research study that will explore the effectiveness of the hospital at home programs using qualitative interviews and quantitative data as a means to also conduct a process evaluation related to the implementation and efficacy of hospital at home programs. the purpose of this pragmatic study is to inform scalability beyond the initial site for implementation within a large healthcare system with a diverse patient population located in various communities, including rural and urban locations.

Eligibility criteria:
inclusion criteria: * patients 18 years and older who are admitted into the hospital at home program after presenting to the emergency department or who are inpatients that can be cared at home for hospital level needs * patients meeting the hospital's criteria for admission by diagnosis type (e.g., heart failure, respiratory infections and inflammations, renal failure, diabetes, pneumonia, bronchitis, chronic obstructive pulmonary disease, fever and inflammatory conditions, viral illnesses, other disorders of the nervous system). diagnoses are determined by clinicians not researchers. * patients will need to reside within 30 minutes' drive time from the hospital patient caregiver inclusion criteria: (not required for patient participation): * age \>= 18 years old * as capacity to consent to study clinician or stakeholder inclusion criteria: * any member of the home hospital clinical team (a healthcare professional who providing care or equipment for use in the home) who will be participating in delivery of healthcare services, * any member of the hospital care teams, including the screening and recruitment of patients for the home hospital intervention and/or providing care to patients that enroll in the intervention that is provided * any member of the leadership team who are involved in the operational aspects of program delivery exclusion criteria: * need for long-term facility level care or current residence in a facility of this type * no one will be excluded on the basis of sex or race

Keywords: home hospital hospital at home hospital in the home
periocular rejuvenation by topical hyaluronic acid nano particles

Conditions: Tear Trough Eyelid Deformity; Dark Eyelids; Wrinkle

Summary: in this study, the investigators aims to evaluate the efficacy and safety of topical hyaluronic acid nanoparticles as a novel nanodermatological tool in periocular rejuvenation as a replacement approach of invasive dermal filler injections.

tear trough deformity is a main concern of many people (males or females) with age range of 21 to 65 years old or older. such condition is characterized by a sunken appearance of the eye that results in an aged and dissipated appearance to the eye.treatment modalities range from camouflage make up, laser resurfacing, platelet-rich plasma therapy, carboxy therapy, mesotherapy, volume augmentation with injectable hyaluronic acid fillers and fat, as well as surgical procedures such as blepharoplasty. consequently, safe, effective and less invasive treatment options of the tear trough have remained a challenge. the study will include 30 adult patients (male or female) suffering tear trough deformity. they will be selected from dermatology outpatient clinic of alexandria main university hospital.

Eligibility criteria:
inclusion criteria: 1. is a healthy male or female between 21 and 65 years old 2. is voluntarily willing to consent to participate in the study 3. is willing to comply with all requirements of the study including being photographed, follow post treatment care instructions, to attend all treatment, and follow up visits 4. willingness to waive rights to use of still photos of themselves for research, marketing, or promotional reasons, including on the internet and on social media outlets. 5. willingness to refrain from other surgical, laser, or injectable treatments in the periorbital region during the entire duration of the study. 6. ability to provide informed consent. exclusion criteria: -

Keywords: periocular rejuvenation tear trough hyaluronic acid topical dark circles wrinkles
milk components and metabolic syndrome

Conditions: Obesity; Metabolic Syndrome

Summary: milk contains a vast number of bioactive components that have been suggested to have a positive impact on human health, of special interest is the effects related to metabolic syndrome and obesity but the effect of the individual milk components is not clear. this study examine whether it is beneficial for overweight and obese children to increase the intake of skim milk, or whey or casein in relation to bodyweight and markers of ms. the participants will be randomized to receive skim milk, whey milk drink, casein milk drink or mineral water for 3 mo. they will be examined at baseline, end of intervention and followed up 3 month later.


Eligibility criteria:
inclusion criteria: * 12 years to 15 years old * iso bmi larger than 25 * habitual milk intake less than 250 ml/day * non-smoker * healthy at the time of inclusion exclusion criteria: * chronic illnesses * intake of antibiotic 1 mo before start of intervention

Keywords: obesity metabolic syndrome milk components casein whey children adolescent
developing and testing an online intervention for alcohol and cannabis misuse and healthy relationship skills among young adult couples

Conditions: Alcohol Drinking; Cannabis Use; Couples

Summary: the goal of this clinical trial is to develop and test a brief online intervention to reduce alcohol and cannabis misuse and improve healthy relationship skills among young adult couples. the main questions it aims to answer are: * will the intervention be feasible and acceptable to young adult couples? * will the intervention demonstrate initial efficacy in reducing risky substance use and increasing relationship functioning? eligible couples will complete a virtual baseline session and be randomized to intervention condition (online intervention with 3-5 weeks of self-paced modules) or control condition (no intervention). couples will complete two follow-up surveys (post-assessment - approximately 5 weeks after baseline, 3-month). couples in the control condition will be offered the intervention after 3-month follow-up. researchers will compare intervention and control groups to see if there there is a difference between the groups on substance misuse and relationship functioning at post-assessment and 3-month follow-up.


Eligibility criteria:
inclusion criteria: * both partners in the couple are 18-29 years old * in a committed romantic relationship (e.g., dating seriously, cohabiting, married) with each other for at least 3 months * face-to-face contact their partner at least 5 days per week * live in washington state * have a valid email address and access to a cell phone * report alcohol and cannabis co-use at least three times in the past month * willingness to: complete online surveys during the allotted time frames, receive text messages and emails from the project, complete a baseline session, and participate during the same time period as their partner exclusion criteria: * couples who endorse any perpetration or receipt of severe interpersonal aggression during screening will be excluded and provided with resources

Keywords: alcohol use, cannabis use, couples, healthy relationships, young adults