Kornimate/medical-research-clean huggingface dataset:
can subclavian / infraclavicular axillary vein collapsibility index predict post-spinal hypotension in caesarean section operations?

Conditions: Post Spinal Hypotension

Summary: postspinal hypotension (psh) is a common side effect with an incidence of 15.3% to 33%, which may result in organ hypoperfusion and ischemic events (1,2). in pregnant patients, this incidence may increase to 70% and severe psh may increase the risk of maternal and fetal complications (3). therefore, it is important for anesthesiologists to estimate the incidence of psh in cesarean sections and to identify possible mechanisms (4). one of the important factors affecting the susceptibility of patients to intraoperative hypotension is the preoperative intravascular volume status. recently, ultrasonography of the central veins has been used frequently by anesthesiologists in the preoperative period in order to evaluate the intravascular volume status (5). salama and elkashlan stated that the collapsibility index of the inferior vena cava is a new predictive value for psh (6). choi et al. showed that the subclavian vein or infraclavicular axillary vein collapsibility index is an important predictive value for hypotension after induction of general anesthesia (7). in this study, we wanted to investigate whether the subclavian vein or infraclavicular axillary vein collapsibility index can be used as a predictive value for psh in cesarean section.


Eligibility criteria:
inclusion criteria: * spinal anesthesia * ceserean operation * american society of anesthesiologists' (asa) physical status i-ii exclusion criteria: * patients who underwent cesarean section in emergency conditions * patients who underwent cesarean section under general anesthesia * american society of anesthesiologists' (asa) physical status iii-iv

Keywords: post spinal hypotension, the subclavian vein or infraclavicular axillary vein collapsibility index
effect of dexmedetomidine on ischemia-reperfusion injury in lower extremity operations

Conditions: Arthroplasty, Replacement

Summary: ischemia reperfusion injury causes the release of free oxygen radicals. the selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. the aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.


Eligibility criteria:
inclusion criteria: * american society anesthesiologists classification i-iii exclusion criteria: * use of antioxidants clinically significant cardiovascular, renal, or hepatic diseases heart block greater than the first degree
adding exercise to antidepressant medication treatment for depression

Conditions: Depression

Summary: this study will assess the effectiveness of an exercise program in improving antidepressant medication treatment for individuals with major depressive disorder (mdd).

partial response to antidepressant treatment is common in people with mdd and is associated with significant morbidity and reduced quality of life. pharmacological therapies have been used to augment the effect of antidepressants; however, such therapies are associated with a range of adverse effects. studies indicate that exercise may be safe and effective in augmenting depression treatment. this study will determine whether exercise can complement selective serotonin reuptake inhibitor (ssri) therapy in people with mdd who have residual symptoms of depression despite drug treatment. participants will be randomly assigned to either high frequency exercise or low frequency exercise for 12 weeks. depression symptoms will be measured weekly. quality of life and satisfaction with the study will also be measured. depression scales and self-reports will be used to assess participants.

Eligibility criteria:
inclusion criteria: * diagnosis of major depressive disorder * score of 14 or higher on the hamilton depression scale (ham-d) * 8 to 12 weeks of ssri treatment, with at least 6 weeks at adequate doses * sedentary lifestyle * physically capable of exercise * body mass index (bmi) less than 40 kg/m2 * willing and able to comply with study requirements exclusion criteria: * significant cardiovascular disease or other medical conditions * uncontrolled hypertension * abnormal exercise stress test * hematologic disorders * comorbid disorders, including depression due to another comorbid condition, psychotic disorder, bipolar disorder, schizophrenia, schizoaffective disorder, eating disorder, or obsessive compulsive disorder (ocd) * alcohol and/or substance abuse in the past 6 months * hospitalization for mental illness within the past year * high suicide risk * use of psychopharmacological or psychotherapeutic treatment other than ssris * failure to respond to two or more adequate pharmacological treatments during the current depressive episode * significantly elevated blood lipids * pregnancy

Keywords: exercise therapy complementary therapies
incidence of refeeding syndrome in consecutively admitted patients

Conditions: Refeeding Syndrome; Starvation; Phosphate Deficiency

Summary: the incidence and main risk-factors analyzed in consecutive in-patients in the departments og gastroenterology and ear-nose and throat diseases (cancer in radiation therapy)

patients with either parenteral- or tube feeding enter the study to assure sufficient nutrition. during hospitalization patients were monitored with daily blood samples and clinical evaluation of symptoms in addition to the coverage of energy and protein in percent of estimated needs. refeeding phenomenon was defined as a decrease in plasma phosphate after the initiation of nutrition. refeeding syndrome as refeeding phenomenon and one or more relevant symptoms in addition (hypotension, cardiac arrhythmia, edema, confusion)

Eligibility criteria:
inclusion criteria: * planned tube- or parenteral nutrition (complete or supplementary) * \> 18 years * written consent exclusion criteria: * renal insufficiency (p-creatinine \>200 micromol/l) * lack of ability to communicate (registration of nutritional intake etc)
a controlled study to investigate the effect of multi-wave light emitting diode (led) bed on blood pressure and endothelial function

Conditions: Hypertension

Summary: the objective of this multi-center study is to investigate the effect of a multi-wave led light bed on blood pressure and endothelial function in pre-hypertensive and mildly hypertensive adults.

subjects will be instructed to lay in the bed for 20 minutes on their stomach followed by 20 minutes on their back for a total of 40 minutes three times per week for 8 weeks. subjects will be instructed to begin light treatment on day 1 after baseline measurements have been collected. subjects will be required to visit a wellness center of dr. bryan or hypertension institute in nashville, informed of the study and if agreed will sign the consent form. after consent, subjects will be required to spend about 30 minutes to get baseline measurements. subjects will then be required to lie in bed for 40 minutes each day three days per week for 8 weeks. blood pressure and endothelial function tests will be recorded at baseline and after each light treatment.

Eligibility criteria:
inclusion criteria: * male or female of 18-75 years of age * if female, subject is not of child bearing potential * subjects with seated resting systolic blood pressures between 130-160 mmhg and diastolic between 85-100 mmhg (inclusive) at screening visit * subjects with mild to moderate endothelial dysfunction * agreement to maintain current level of physical activity and diet throughout the study * agrees to comply with study procedures including abstain from coffee at least 14 hours before blood pressure measurement and abstain from physical exercise at least 4 hours before blood pressure measurement * has given voluntary, written, and informed consent to participate in the study exclusion criteria: * females who are pregnant, breastfeeding, or planning to become pregnant during the course of the study * seated office systolic blood pressure outside of the target range (systolic blood pressure \ 160 mmhg) or diastolic blood pressure \ 100 mmhg at screening * the use of natural health products for the treatment of hypertension within 2 weeks of screening * significant cardiac history defined as a history of myocardial infarction (mi); coronary angioplasty or bypass graft(s); valvular disease or repair; unstable angina pectoris; transient ischemic attack (tia); cerebrovascular accidents (cva); congestive heart failure; or coronary artery disease (cad) * type i diabetes * unstable medical conditions that in the opinion of the principle investigator preclude the subject from participating in the study * alcohol or drug abuse within the last 6 months * participation in a clinical research trial within 30 days prior to randomization * individuals who are cognitively impaired and/or who are unable to give informed consent * any other condition which in the investigator's opinion may adversely affect the subject's ability to complete the study or its measures or which may pose significant risk to the subject
study to measure the prevalence of asynchrony in mechanically ventilated patients

Conditions: Patient/Ventilator Asynchrony

Summary: this study will examine the prevalence of patient-ventilator asynchrony and its determinants. mechanically ventilated trauma patients often experience asynchrony when their pattern of breathing does not match the triggering of a mechanical ventilator. asynchrony is thought to be more common in delirious patients, patients with chronic lung disease and those who are heavily sedated. the study will examine the relationship between (1) delirium and sedation and (2) the prevalence of asynchrony in trauma patients.

this is a prospective observational study to determine the prevalence of patient/ventilator asynchrony in a cohort of trauma and surgical patients. there will be two 20-minute periods of observation. the first will be during the first 24 hours of mechanical ventilation and the second will take place when the patient is being weaned from the ventilator and is triggering half or more of all ventilator breaths. the study team will use computer-captured waveforms to determine the proportion of all breaths that are asynchronous. this proportion is the primary outcome variable of the study. the study hypothesis is that the proportion of asynchronous breaths is higher in patients with higher levels of sedation, as measured by the richmond agitation-sedation scale (rass) and the confusion assessment methods for the intensive care unit (cam-icu). this hypothesis will be tested using repeated measures analysis of variance.

Eligibility criteria:
inclusion criteria: * trauma or surgical diagnosis * patients requiring mechanical ventilation exclusion criteria: * patients with no spontaneous breathing efforts due to injury or chemical paralysis * patients with leaks in the patient ventilator system precluding evaluation of waveforms

Keywords: asynchrony mechanical ventilation blunt trauma
plasma rich fibrin epidural injection by racz catheter in postdural puncture headache guided optic nerve sheath diameter

Conditions: Plasma Rich Fibrin; Epidural; Racz Catheter; Postdural Puncture Headache; Optic Nerve Sheath Diameter

Summary: this study aims to evaluate plasma-rich fibrin epidural injection by racz catheter in post-dural puncture headaches guided optic nerve sheath diameter.

postdural puncture headaches (pdphs) are a recognized complication following unintentional dural puncture during epidural analgesia or intentional dural puncture for spinal anesthesia, diagnostic, or interventional neuraxial procedures. plasma-rich fibrin (prf) is derived from autologous whole blood that contains and releases several different growth factors and cytokines to stimulate the healing of bone and soft tissue via degranulation, which has recently gained popularity in pain management. optic nerve sheath diameter (onsd) is important because the optic nerve is surrounded by subarachnoidal cerebrospinal fluid and all three meningeal layers, and a change in the onsd can indicate changes in intracranial pressure.

Eligibility criteria:
inclusion criteria: * age from 18 to 65 years. * both sexes. * patients suffering from severe post-dural puncture headache. exclusion criteria: * uncooperative patients. * severe comorbid conditions. * pregnancy. * anticoagulant therapy. * known allergies to plasma rich fibrin components. * body mass index (bmi) ≥35 kg/m2.
a study to determine the best dose of antivirals in patients with both tb and hiv

Conditions: HIV Infections; Tuberculosis

Summary: because drugs used to treat tb can reduce the amount of the anti-hiv drugs that reach the sites where the virus is located, this study is designed to see whether it is necessary to use higher doses of antiviral (anti-hiv) drugs while patients are receiving therapy with rifampin, one of the drugs commonly used to treat tb. participants will be assigned to one of 4 arms (see below) and will be followed during the time when they are receiving both treatments.

this is an open label, randomized study with 4 arms: 1.) standard dose and 2.) high dose nevirapine; and 3.) standard dose and 4.) high dose efavirenz. subjects in all 4 arms will also receive 2 nucleoside analog drugs. patients will have routine monitoring for the treatment of tb and hiv, as well as some additional blood samples to follow the virus in the blood and to determine the effect of the tb therapy on the amounts of anti-hiv drugs that are in the body.

Eligibility criteria:
inclusion criteria: * arv naïve subjects * documented hiv infection * documented tb infection * platelet count 40,000/mm3 * hemoglobin ≥8.0 g/dl * absolute neutrophil count (anc) \>500/mm3 * ast (sgot), alt (sgpt), and alkaline phosphatase \<3 x uln * total bilirubin \<2.5 x uln * calculated creatinine clearance ≥60 ml/min * for women of reproductive potential, negative urine pregnancy test exclusion criteria: * unable to provide informed consent. * history drug abuse that the investigators suspect will interfere with compliance to study medications and visits. * patients on hemodialysis. * tuberculosis meningitis. * women with cd4 \> 250 and men with cd4 \> 400 due to higher risk of hepatotoxicity related to use of nvp. * positive serology for hepatitis c. * evidence for active hepatitis b including positive serologies for hbsag, hbeag, or hbv-dna. note: if anti-hbs is positive, patient is eligible for study if liver enzymes are within the parameters indicated in the inclusion criteria * women who are breast-feeding * known allergy/sensitivity to study drug(s) or their formulations * patients with other ois or intercurrent illness that could affect their ability to take study drugs

Keywords: co-infection tuberculosis hiv drug interactions non nucleoside reverse transcriptase inhibitors therapy treatment naive
efficacy of biodex balance training versus whole body vibration training in patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: this study will be conducted to answer the research question: are there differences between the effect of biodex balance training and whole-body vibration training on knee osteoarthritis?

the purpose of this study is to compare the effects of biodex training balance versus whole body vibration training on knee osteoarthritis on: * pain intensity * static balance * dynamic balance * functional ability level

Eligibility criteria:
inclusion criteria: 1. subjects age between (40-60) years old. 2. radiologic findings had to be compatible with knee oa grade 2 in a simple x ray. 3. tenderness on medial tibial plateau 4. intensity of pain: visual analogue scale equal to 5 or greater 5. failure of two or more types of previous conservative treatment (medication, anti-inflammatory drugs, physical therapy, stretching, acupuncture, orthotics and others) in the last three months exclusion criteria: 1. neurological and vestibular system disorder, systematic inflammatory disease, steroid injections in the last six months 2. subjects with diabetes mellitus. 3. acute symptomatic arthritis 4. other conditions (such as osteomyelitis, tuberculosis, and tumor) that affect their walking function; had a contraindication to exercise; and exhibited cognitive impairment
the factors affecting the achievement of glucose monitor in the patients on diabetes

Conditions: Glucose Variability; Cognitive Decline

Summary: to assess the effect of glucose monitors on glucose control and cardiovascular risks.

the investigators will enroll patients with diabetes. the answered questionnaire and blood samples will be collected at baseline. after change the methods or frequency of glucose monitor, the blood samples will be collected again. the investigators will analyze the factors which may affect the glucose control after changes in methods of glucose monitor.

Eligibility criteria:
inclusion criteria: * adults with diabetes exclusion criteria: * incooperative patients

Keywords: brain-derived neurotrophic factor vascular cell adhesion molecule 1 renalase orexin continue glucose monitor
cardiovascular risk clinic

Conditions: Cardiovascular Disease; Coronary Artery Disease; Hypertension; Diabetes; Obesity

Summary: this study was a prospective, randomized trial designed to investigate the efficacy of moderate lifestyle modification for improving the clinical status of patients with coronary artery disease or patients with risk factors that promote coronary artery disease.

the main hypothesis to be tested in the cardiovascular risk clinic was: can individualized therapeutic lifestyle plans in conjunction with molecular analysis lead to informative assessments of disease risk that can reduce risk factors for diabetes and cardiovascular disease. our main objectives were: a. to investigate the effect of lifestyle modification on: (1) physiological measurements of coronary artery disease (cad) including carotid intima-media thickness (cimt), exercise stress tests, blood pressure, body mass index (bmi), and weight; (2) plasma markers associated with development of cad such as lipids and triglycerides; and (3) molecular characteristics such as gene expression signatures and protein profiles. b. to determine if patients with heart disease or risk factors that would promote heart disease can achieve and adhere to the goals of a lifestyle change program in a non-residential, out-patient setting.

Eligibility criteria:
inclusion criteria: at least one known risk factor for cardiovascular disease: * family history of cad (first degree relative) * physician-diagnosed diabetes or stroke * overweight (bmi/=25) or obese (bmi\>/=30) * total cholesterol \>/=200, documented history of hypercholesterolemia, or currently taking lipid lowering medications * history of smoking * hdl \</=44 mg/dl * ldl \>/=130 mg/dl or documented history of hyperlipidemia * elevated triglycerides (\>/=200 mg/dl) * hypertension (systolic blood pressure \>/=130 mmhg, diastolic blood pressure \>/=85 mmhg, documented diagnosis of hypertension, or currently taking antihypertensive medications) * diabetes (fasting glucose \>/=100 mg/dl, physician diagnosis of diabetes/pre-diabetes, or currently taking anti-glycemic medications) * post traumatic stress disorder (ptsd) or at risk for ptsd * insomnia (five hours of sleep per night or less) or sleep apnea exclusion criteria: * age \<18 years of age * unstable coronary syndromes, refractory congestive heart failure, uncontrolled arrhythmia, or high-grade uncorrected cardiac conduction abnormalities * any contraindication to components to program, such as physical disabilities precluding stretching and aerobic exercise or medical conditions that preclude consumption of foods essential to program diet * inability or unwillingness to give consent * significant left main stenosis (\>50%) or ejection fraction \<35% with no revascularization * history of substance abuse (including alcohol) without self-certification of abstinence for at least three months * non-ambulatory (bedridden) individuals

Keywords: lifestyle modification diet exercise cardiovascular disease gene expression obesity
utilizing long-read sequencing to investigate the egfr landscape of egfr positive lung cancer patients

Conditions: Lung Cancer - Non Small Cell; EGFR Exon 19 Deletion Mutation

Summary: egfr gene mutations are some of the most commonly occurring mutations in non-small cell lung cancer. investigators have developed a dna instability model that estimates a risk score to assess the likelihood of an individual acquiring a cancer-linked mutation. the aim of this study is to collect blood from both those diagnosed with egfr positive lung cancer and healthy individuals, evaluate their gene sequence surrounding the egfr landscape and use the cancer positive and healthy sequences to validate the risk assessment model, which may one day be used to provide insight on susceptibility of getting egfr positive lung cancer or potentially other cancer types.


Eligibility criteria:
inclusion criteria: * 18-100 years old * biologically born female * diagnosed with egfr positive lung cancer (arm 1-cancer group) * no cancer diagnosis (arm 2-health control) exclusion criteria: * less than 18 years of age * biologically born male * incarcerated at the time of participation

Keywords: lung cancer egfr gene