Kornimate/medical-research-clean huggingface dataset:
identifying physical activity intensity through accelerometry in heart failure

Conditions: Heart Failure

Summary: the primary objective of this study is to identify and evaluate the range of values provided by accelerometers during a variety of typical daily lifestyle activities for heart failure patients, and to relate these to the measured intensity of performing each activity in the heart failure population.

the precise measurement of physical activity is now possible with advances in wearable technology, namely accelerometers. this is useful in order to properly evaluate interventions such as cardiac rehabilitation that aim to increase physical activity. one of the challenges with accelerometry is the need for raw data to be translated into meaningful behavioural units. this is addressed through a calibration study, where accelerometry data is related to oxygen consumption and cut points are derived where activity is considered light, moderate or vigorous intensity. however, calibration studies have only been done in young and healthy adults, not in the elderly or those with chronic disease such as heart failure where movements are slower and exercise capacity is reduced. this means there is a risk of underestimating the true level of physical activity in this population. therefore the aim of this study is to run a calibration study with 18-30 heart failure patients. adults (aged 18 years and older) diagnosed with heart failure, with stable symptoms that are willing and able to give informed consent will be eligible for the study. patients with contraindications to physical activity will be excluded from the study. patients will be identified from the royal devon \& exeter nhs foundation trust and the study will be conducted in the sports science laboratory at st luke's campus, university of exeter. each patient will be required to attend a single study visit that should last approximately 3 hours in total. during the visit patients will be required to complete a number of physical activity tasks (such as lying, sitting and walking) whilst wearing various accelerometers and gas analysis equipment.

Eligibility criteria:
inclusion criteria: * patient willing and able to give written informed consent to participate in study * adult (aged ≥18 years) * patients with confirmed diagnosis of heart failure * stable symptoms of heart failure exclusion criteria: * patients with contraindications to exercise testing or physical activity * patients who are in a long term care establishment or who are unwilling or unable to travel to research site * patients who are unable to understand the study information. * patients judged to be unable to participate in the study for any other reason (e.g. diagnosis of dementia, psychiatric disorder, life-threatening comorbidity).

Keywords: physical activity accelerometer
high-intensity interval training in overweight/obese

Conditions: Obesity, Metabolically Benign

Summary: purpose: the purpose of this study would be to evaluate the effects of interval training on cardiovascular health, lipid profile and body composition in overweight and obese men and women. a secondary purpose will be to compare lab based measurements of body composition \[4-compartment model (4c)) with portable equipment \[bioelectrical impedance spectroscopy (bis) and ultrasound (us)\] participants: seventy-six men and women (age 18-55 yrs; bmi 25-45 kg/m2) will be randomly assigned to a high-intensity short interval group (sit), high-intensity long interval group (hit) or a control group (con). procedures (methods): participants will be assessed for peak oxygen utilization (vo2peak), blood lipids, glucose and insulin levels. body composition will also be measured using a 4c model, as measured from dual energy x-ray absorptiometry (dexa), air displacement plethysmography (bodpod), and bis, in comparison to us values. participants assigned to either training group will undergo 3 weeks of interval training, 3 days per week. sit will complete 10 bouts of a series of 1 min cycling with 1 min rest periods at 90% of the power output obtained during vo2peak;in comparison hit will complete 5 bouts of the same protocol: 2 min bouts with 1 min recovery at varying intensities of vo2peak (80-100% power output).


Eligibility criteria:
inclusion criteria: * written and dated informed consent to participate in the study. * willing and able to comply with the protocol. * good health as determined by a health and exercise status questionnaire * normal electrocardiogram (ecg), and physical. * body mass index of 25-45 kg/m 2. * has been cleared for participation by a physician (either study or personal). exclusion criteria: * participating in another clinical trial or have received an investigational product within thirty days prior to enrollment. * has lost ten or more pounds during the previous three months and maintained the weight loss. * significant history or current presence of untreated high blood pressure (bp) \[systolic bp\> 140 mmhg and/or diastolic bp\> 90 mmhg\], thyroid disease, tachyarrhythmia, heart disease, kidney disease, or liver disease. subject currently suffers from/or has a known history of (or is currently being treated for) clinical depression or an eating disorder(s). * has any medical condition or uses any medication, nutritional product, dietary supplement or program, which in the opinion of the investigator, might interfere with the conduct of the study or place the subject at risk. * are identified as moderate to high risk individuals by the american college of sports medicine will be excluded from the study.
growth hormone to improve the clinical outcome of assisted fertility in young patients with decreased ovarian reserve

Conditions: Infertility

Summary: this study was a prospective randomized controlled trial. patients aged \ 10miu/ml, anti-mullerian hormone \< 1.1μg/l) and receiving ivf/icsi assisted ovulation induction in our hospital were included in this study. after randomization using excel(microsoft corporation, albuquerque, usa), these patients were divided into two groups. group a was the experimental group, which was treated with growth hormone for 3 months (2 units per day) before ivf/icsi. group b was the control group, which was directly assisted by ivf/icsi.


Eligibility criteria:
inclusion criteria: 1. age \< 35 years; 2. afc≤5 3. follicle stimulating hormone \> 10miu/ml; 4. anti-mullerian hormone \< 1.1μg/l (2 out of 2-4 items can be met) exclusion criteria: 1. severe male factors: spermatozoa collected by testicular sperm aspiration (tesa) or percutaneous epididymal sperm aspiration (pesa) was used for intracytoplasmic sperm injection (icsi) cycle of single spermatozoa; 2. patients with severe adenomyosis, endometriosis, intrauterine adhesions and other diseases that significantly affect embryo implantation; 3. diabetes mellitus, insulin resistance; 4. chromosomal karyotype abnormality in either spouse; 5. any pregnancy or contraindications of assisted reproductive technology;
motiv study- effect of antidepressive treatment by escitalopram in patients undergoing coronary artery bypass grafting

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to determine the effect of an antidepressive medication (escitalopram), started preoperatively and given during 6 months, on 6-month and 1 year post-operative morbidity and mortality after coronary artery bypass grafting

depression is known to have an adverse effect on post-operative mortality and morbidity after coronary artery bypass grafting. cardiac surgery is known to cause transient depression in patients. the purpose of this double-blind, randomized study is to determine the effect of an antidepressive medication (escitalopram), started preoperatively and given during 6 months, on 6-month and 1 year post-operative morbidity and mortality after coronary artery bypass grafting. treatment is given from 21 to 15 days pre-operatively until the 6th post-operative month. morbidity as defined by the sts database as well as mortality is checked during 1 year.

Eligibility criteria:
inclusion criteria: * patients undergoing elective coronary artery bypass surgery * \> 30 years old exclusion criteria: * contra-indication to antidepressive treatment * already treated by antidepressive treatment * concomitant cardiac surgery as valve replacement etc. * patients having anticoagulation therapy * pregnant women * hepatic insufficiency

Keywords: coronary artery bypass surgery
single incision laparoscopic gastric banding versus conventional five port laparoscopic gastric banding

Conditions: Morbid Obesity

Summary: gastric banding has been shown to significantly reduce weight and has been approved as a treatment of morbid obesity. the standard laparoscopic operation requires five small incisions for the introduction of instruments and the band into the patient's abdomen. we have developed a technique for performing this operation through a single incision at the belly button. this study compares this method to the conventional 5-incision approach.


Eligibility criteria:
inclusion criteria: * bmi \> 40 * asa class i or ii exclusion criteria: * comorbid cardiac, pulmonary, renal, hepatic disease * bleeding disorder * previous gastric/esophageal surgery
prader-willi syndrome body composition

Conditions: Prader Labhart Willi Syndrome; Body Weight Changes; Sarcopenia

Summary: adults aged over 18 years, with the diagnosis of prader-willi syndrome will be recruited through the hospital's outpatient clinic for either as intervention group receiving therapeutic elastic band training, or as control group receiving usual care for a total of 16 weeks. body composition, physical capacity, and serum changes will be assessed before and after the intervention.

participants that fulfill the inclusion criteria will be assigned into one of the two arms: elastic band intervention group (eb) or control group (cg). both groups will received a baseline: dual x-ray absorptiometry body composition, physical capacity, and serum markers examinations. eb will then receive a 16-week progressive elastic band resistance exercise training, while the cg will receive usual care. after the 16 weeks from the baseline assessment, a followed-up: dual x-ray absorptiometry body composition, physical capacity, and serum examinations will be assessed.

Eligibility criteria:
inclusion criteria: * aged 18-65 years old. * genetically diagnosis of prader-willi syndrome. * must be able to follow and understand mandarin instructions and cooperate to the exercise assessments and/or training. exclusion criteria: * prader-willi syndrome individuals unable to sit, stand and walk independently which make physical capacity assessment difficult. * severe arthritis, fracture, or other musculoskeletal deformities that interfere with exercise training. * severe cognitive impairment who cannot read, write the informed consent.

Keywords: prader willi syndrome body composition sarcopenia resistance training physical capacity
phase ii trial of rad001 in refractory colorectal cancer

Conditions: Colorectal Cancer

Summary: single center open-label study of an oral agent (rad001) in subjects with metastatic colorectal cancer refractory to at least 2 standard chemo/biologic regimens.

study is completed and closed.

Eligibility criteria:
inclusion criteria: * metastatic colorectal cancer refractory to at least 2 chemo/biologic regimens * measurable disease * ecog 0-2 exclusion criteria: * cns disease * chemotherapy or radiotherapy \< 4 weeks prior * active bleeding diathesis

Keywords: metastatic refractory
reclean pilot study

Conditions: Lead Poisoning

Summary: this is an exposure assessment pilot study tailored for families of construction workers living with a child. the investigators will compare home dust metal levels and resident's blood metal levels before and after an educational and environmental intervention. a baseline and a post intervention period assessment will be conducted with home and car lead inspections and risk assessments with collection of dust, urine, blood and toenail samples and a survey. objectives of this research are to: 1. to characterize pre-intervention home exposures to lead and other metals in households with one construction worker inhabitant living with a child, by assessing household members' biospecimens and home dust metal levels. 2. to develop and evaluate customized home interventions (including environmental and educational approaches) to reduce metals exposure in three tiers of intervention. 3. to characterize home exposures to lead and other metals post intervention and determine adapted behaviors and whether the degree of metals exposure reduction (including take home exposures) in the households depends on the level of intervention.


Eligibility criteria:
first, construction workers will be recruited. second, household members of the construction worker will be recruited. inclusion criteria: construction workers must meet all of the following inclusion criteria: 1. 18 years of age or older 2. works full time in construction with high risk for metal exposures 3. lives in the greater boston area 4. lives with at least 1 child household member 1 year of age or older (does not have to be a child of the worker but interested in participating in the study) 5. speaks english or spanish. household resident participants must meet all of the following inclusion criteria: 1. child (1 - 17 years of age) or adult (18 years of age or older) 2. lives in the greater boston area with the worker participating in this study 3. speaks english or spanish. exclusion criteria: none

Keywords: blood lead level construction workers household member exposure national health and nutrition examination survey (nhanes)
explore the association between neuropsychological functions and adhd diagnosis and comorbid using longitudinal study in preschool children

Conditions: Attention Deficit/Hyperactivity Disorder

Summary: the current study using the longitudinal study in preschool children to exam three study issues: 1) using the neuropsychological functions (ie. behavioral inhibition, delay aversion, the variability of reaction time) among the preschool children predict the adhd diagnosis and behavior symptoms in 1.5 years later. 2) using the behavior inhibition, delay aversion and the variability of reaction time (using the parameter among gaussian distribution and ex-gaussian distribution) explore the association between attention and motor inhibition problems. 3) explore the transaction effect between the neuropsychological functions and family function and parenting to predict adhd comorbidity with oppositional defiant disorder.4) explore the association between the internalizing/ externalizing problems of adhd and temperament. the current study has opportunity to describe and to answer the complicated problems for heterogeneous neuropsychological deficits in adhd, and to elucidate the core issues for adhd have comorbid with odd. the most important contribution is to offer the empirical evidence to make a clean suggestion in adhd diagnosis and intervention in preschool age.

the current study would follow the same participants for 1.5 years, time 1 is around 4-5 years old, and time 2 is around 6-7 years old. participants: * 100 typical developmental control * 120 adhd high risk preschool children at time 1 the diagnosis at time 2 to have three groups in this study: * adhd persistent * adhd remission * typical developmental control the measurements were included * the different neuropsychological test (ie. behavioral inhibition, delay aversion, and vigilance task) * the adhd behavioral rating scales and diagnosis interview * the scaling for family function and parenting * intellectual assessment this study could offer the suggestion for the further intervention in adhd.

Eligibility criteria:
inclusion criteria: 1. control group * the subjects without adhd. * ages range from 4 to 5 * full scale iq ≥ 80 * the subjects who and whose parents consent to this study. 2. adhd high risk group * patients who have clinically diagnosis of dsm-iv adhd confirmed by the psychiatrists or have the risk of becoming adhd confirmed by the adhd behavioral rating scales. * ages range from 4 to 5 * full scale iq ≥ 80 * patients who and whose parents consent to this study. exclusion criteria: * mental retardation * schizophrenia, schizoaffective disorder * mood disorders * organic psychosis * learning disorder * pervasive developmental disorder * the subjects of control group if have a history of the following condition as defined by dsm-iv: adhd in addition to the above exclusion criteria will be excluded.

Keywords: adhd in preschoolers neuropsychological functions behavior inhibition family function and parenting
radiomic assessment in nsclc: correlation between multiparametric imaging biomarkers and genetic biomarkers

Conditions: Lung Cancer

Summary: the purpose of this study is to evaluate relationships between multiparametric imaging biomarkers and genetic analysis in nsclc patients.

to evaluate relationships between multiparametric imaging biomarkers(ct, pet/ct, mri) and genetic analysis in nsclc patients

Eligibility criteria:
inclusion criteria: * suspected lung cancer on chest ct or histologically proven nsclc * participant is being considered for the conventional/neoadjuvant/targeted chemotherapy or surgery * at least one measurable primary or other intrathoracic lesion \>= 2cm, according to recist * performance status of 0 to 2 on the ecog scale * age 20 years or older * able to tolerable pet/ct and ct imaging required by protocol * able to undergo percutaneous needle biopsy before and after chemotherapy * able to give study-specific informed consent exclusion criteria: * poorly controlled diabetes * contraindication for ct contrast agent

Keywords: ct pet ct mri cancer genomics radiomics radiogenomics
pilot: digital therapeutic vs education for the management of problematic substance use

Conditions: Alcohol Use Disorder (AUD); Substance Use Disorders

Summary: prior to launching a randomized controlled trial, this pilot study will investigate the feasibility and acceptability of the administration of a diagnostic interview and collection of a biomarker test, as well as engagement and preliminary efficacy with w-suds and the education arm, among a sample of adults who screen positive for problematic substance use.


Eligibility criteria:
inclusion criteria: 1. have a smartphone 2. endorse a substance use concern 3. be between 18 and 65 years of age 4. be available and committed to engage with the woebot app 5. be literate in english.(this is required for inclusion because all materials will be in english). exclusion criteria: 1. pregnancy (as w-suds will not be specifically developed to address the unique needs of this population) 2. suicide attempt within the past year (12 months) 3. symptoms of severe drug/alcohol history: history of delirium tremens; experiencing hypertension, drenching sweats, seizures or confusion after stopping alcohol or drugs; liver trouble (cirrhosis or hepatitis); convulsions or gi bleeding due to drug/alcohol use 4. opioid overdose within the past year (12 months) 5. opioid misuse without medication-assisted treatment 6. not residing in the u.s. 7. ever used woebot
endoscopic subsurface optical imaging for cancer detection

Conditions: Bladder Cancer

Summary: the purpose of this pilot study is to develop the methodology for an innovative subsurface imaging technology that was designed at lawrence livermore national laboratory. it will allow the non-invasive analysis and imaging of tissues and chemical distributions in the body at an imaging depth of up to 1 centimeter with spatial resolution on the order of 1 mm.

this is a pilot, feasibility study to determine if the subsurface imaging technology warrants advancement to a larger clinical trial.

Eligibility criteria:
inclusion criteria: * patient must be scheduled for a bladder procedure (turbt or cystectomy) at the university of california davis medical center. exclusion criteria: * non bladder surgical procedures at university of california davis medical center.

Keywords: bladder cancer laser optical
prediction model for postoperative aki in patients undergoing lung transplantation using machine learning

Conditions: Lung Transplantation

Summary: since 1963, lung transplantation progress has surged due to immunosuppressive agent advancements. in 2004, 1,815 global lung transplantations were reported. elderly recipients face impaired lung function and health instability, leading to potential respiratory complications post-surgery. postoperative acute renal injury (aki) can cause temporary or chronic dysfunction, increasing hospitalization, complications, and additional treatment needs. various factors contribute to postoperative renal dysfunction after lung transplantation, including sustained hypoperfusion, bleeding, heart failure, acute myocardial infarction, pulmonary embolism, sepsis, and medications. retrospective analysis of adult lung transplant patients' records aims to explore characteristics, anesthesia methods, intraoperative tests, and postoperative acute renal dysfunction, analyzing incidence and risk factors to develop a machine learning predictive model.

since the first report of lung transplantation in humans in 1963, there has been rapid progress in both the quantity and quality of lung transplantation, driven by the significant advancements in immunosuppressive agents since the mid-1990s. in 2004, a total of 1,815 lung transplantations were reported worldwide. patients undergoing lung transplantation are often elderly and face not only impaired lung function but also overall health instability, leading to the potential occurrence of respiratory complications post-surgery, even with successful lung transplantation outcomes. postoperative acute renal injury (aki) can result in temporary or even chronic renal dysfunction. aki following surgery can lead to an increase in hospitalization duration, complications, and the need for additional treatment. various factors are associated with postoperative renal dysfunction after lung transplantation, including sustained hypoperfusion, hypoperfusion related to intraoperative and postoperative bleeding, heart failure, acute myocardial infarction, pulmonary embolism, sepsis, and more. medications related to renal dysfunction include those associated with thrombosis or embolism, such as aminoglycosides, amphotericin b, non-steroidal anti-inflammatory drugs (nsaids), proton-pump inhibitors, contrast agents, and others. additionally, graft-versus-host disease is known to be related to renal dysfunction. the retrospective analysis of medical records from adult patients who underwent lung transplantation aims to investigate patient characteristics, anesthesia methods, intraoperative tests, and the occurrence of postoperative acute renal dysfunction. the goal is to analyze the incidence and risk factors of postoperative renal dysfunction and develop a predictive model through machine learning.

Eligibility criteria:
inclusion criteria: * adult patients 18 years of age or older who underwent lung transplantation for end-stage lung disease exclusion criteria: * none.