Kornimate/medical-research-clean huggingface dataset:
whole body vibration and external load exercise training on cardiovascular and autonomic function in obese individuals

Conditions: Obesity

Summary: obesity is directly related to arterial dysfunction and negatively associated to muscle strength. high-intensity resistance exercise is the favored modality to offset muscle weakness, yet, adverse effects on arterial function (pulse wave velocity, wave reflection, and aortic and brachial blood pressures) have been observed. conventional unloaded-whole body vibration training (wbvt) has improved arterial function in overweight/obese women but appears to be low-intensity. nevertheless, the effects of moderate-intensity (by adding external load) wbvt on arterial and muscle function are unknown. therefore, the purpose of this study was to examine whether loaded-wbvt would induce greater benefits than unloaded-wbvt on arterial and muscle function in young overweight/obese women. furthermore, we examined whether these changes were similar to healthy lean young women.

the purpose of this study was to determine the effects of 6 weeks of loaded-wbvt on arterial stiffness, peripheral and aortic blood pressures, wave reflection, endothelial function, and muscle strength in overweight/obese women. the specific aims of the study were: 1. to examine whether 6 weeks of loaded-wbvt was more beneficial than unloaded-wbvt in decreasing cardiovascular risk factors by assessing arterial stiffness (aortic, leg, and systemic), aortic blood pressures and wave reflection, brachial blood pressures, autonomic function, endothelial function, and blood flow (leg and arm). 2. to determine the extent to which 6 weeks of loaded-wbvt improved body composition measured by changes in fat and lean mass utilizing dual-energy x-ray absorptiometry and waist circumference. 3. to evaluate the effect of 6 wees of loaded-wbvt on muscle strength by using the one-repetition maximum test (leg press and chest press exercises).

Eligibility criteria:
inclusion criteria: * female * 18 to 25 years of age * sedentary (less than 120 min per wk) * 15 lean (body mass index of 18-25 kg/m²) * 45 overweight/obese (body mass index of 27-39.9 kg/m²) exclusion criteria: * younger than 18 or older than 25 years of age * body mass index lower than 18 or higher than 39.9 * physically active or competitively active * smokers * pregnant * irregular menstrual cycle * use of dietary supplementations (e.g.,l-arginine,l-citrulline,antioxidants) * any contraindications to exercise and/or whole-body vibration exercise

Keywords: arterial function whole-body vibration training aortic blood pressures wave reflection muscle strength endothelial function blood flow
a study of shr6390 in combination with letrozole or anastrozole or fulvestrant in patients with hr positive and her2 negative advanced breast cancer

Conditions: Advanced Breast Cancer

Summary: this is a phase ib/ii clinical trial to evaluate the efficacy and safety of shr6390 in combination with letrozole or anastrozole or fulvestrant. patients who have hr positive and her2 negative recurrent/metastatic breast cancer and have not received systemic anticancer therapy are eligible for study.


Eligibility criteria:
inclusion criteria: 1. has the pathologically-confirmed diagnosis of locally recurrent or metastatic, hormone-receptor positive, her2 negative breast cancer. 2. age: 18 - 75 years old, postmenopausal women.prepostmenopausal women, but should receive ovary castration. inclusion criteria 3. cohort 1 and cohort 2 :no prior systemic anti-cancer therapy for advanced hr+ disease. cohort 3 and cohort 4 : patients must satisfy the following criteria for prior therapy: 1. a) progressed after 2 years during treatment of adjuvant therapy with an aromatase inhibitor if postmenopausal, or tamoxifen if pre- or perimenopausal. b)progressed within 12 months of completion of adjuvant therapy with an aromatase inhibitor if postmenopausal, or tamoxifen if pre- or perimenopausal. c) progressed while 6 month after the end of prior aromatase inhibitor therapy for advanced/metastatic breast cancer if postmenopausal, or prior endocrine treatment for advanced/metastatic breast cancer if pre- or perimenopausal. 2. one previous line of chemotherapy for advanced/metastatic disease is allowed in addition to endocrine therapy. 4. eastern cooperative oncology group \[ecog\] 0-1 measurable disease as per response evaluation criterion in solid tumors\[recist\] 1.1 5. adequate organ and marrow function exclusion criteria 1. confirmed diagnosis of her2 positive disease 2. patients who received any endocrine therapy as neo/adjuvant therapy for breast cancer are eligible. if the neo/adjuvant therapy of any endocrine therapy , the disease-free interval must be greater than 12 months from the completion of treatment until study entry. 3. patients who received prior treatment with any cdk4/6 inhibitor, everolimus,fulvestant. 4. clinically significant cardiovascular and cerebrovascular diseases,including but not limited to severe acute myocardial infarction within 6 months before enrollment, unstable or severe angina, congestive heart failure (new york heart association (nyha) class \> 2), or ventricular arrhythmia which need medical intervention. 5. has known active central nervous system metastases.

Keywords: cdk4/6 inhibitor breast cancer postmenopausal women hormone-receptor positive her2 negative premenopausal women
open-label study of neuraminidase inhibitor treatment in stemi patients

Conditions: ST Elevation Myocardial Infarction; STEMI

Summary: neuraminidase-1 can cause the removal of terminal sialic acid residues from the cell surface or serum sialyloconjugates. the level of neu5ac was positively related to the activity of neuraminidase-1. elevation of neu5ac was observed in myocardial ischemia animal model, as well as patients with coronary artery disease. it is interesting to note that neu5ac and its regulatory enzyme neuraminidase-1 seem to play a key role in triggering myocardial ischemic injury. oseltamivir, a structural mimic of sialic acid, was widely used as anti-influenza drug. it suppressed neuraminidase-1 activity in the heart. targeting neuraminidase-1 may represent a new therapeutic intervention for coronary artery disease. this project seeks to identify whether neuraminidase inhibitor (oseltamivir) treatment could decrease the myocardial infarct size in stemi patients and improve clinical outcomes.


Eligibility criteria:
inclusion criteria: 1. between the ages of 18 and 75, regardless of gender; 2. stemi should be diagnosed by two attending physicians or above, including history, clinical symptoms and signs; 3. participate voluntarily and sign informed consent, and can be followed up for more than one month. exclusion criteria: 1. allergic to oseltamivir; 2. creatinine clearance rate less than 60%; 3. severe liver insufficiency; 4. female patients who have or plan to become pregnant; 5. life expectancy less than one year; 6. patients refused to comply with the requirements of this study; 7. according to the discretion of investigator, the patient was unable to complete the study or comply with the requirements of the study (for administrative or other reasons).
effects of montelukast on airway regulatory t cells in asthma

Conditions: Asthma

Summary: montelukast is one of anti-inflammatory agents and a good controller for the patients with asthma. the hypothesis of the study is that the montelukast will have airway anti-inflammatory effects and up-regulated regulatory t cells functions in asthma.


Eligibility criteria:
inclusion criteria: * asthma * mild status * stable status * nonsmoker * positive of airway hyperresponsiveness (methacholine-pc20\<16mg/ml) exclusion criteria: * taken other asthmatic medications such as oral, injective, and inhaled steroids, leukotriene antagonists, oral, inhaled, and transdermal beta-agonists, theophylline, anti-histamine agents, anti-ige antibodies and long acting muscarinic receptor antagonists. * respiratory tract infections within 4wks * moderate to severe other organ disorders * active malignancies * past histories of side effects of leukotriene antagonists * psychological disorders * pregnancy or nursing

Keywords: asthma regulatory t cells leukotriene antagonist
smartphone-based self-management in copd patients: a needs assessment survey

Conditions: Chronic Obstructive Pulmonary Disease

Summary: copd patients often experience multiple symptoms (e.g. dyspnea, cough, and deteriorating quality of life) and have imposed a substantial economic and social burden on health care. the current proposal is to explore the information needs of copd patients and to evaluate the feasibility and acceptability of a smartphone-based instant messaging self-management support program to improve the quality of life in patients with copd.

chronic obstructive pulmonary disease (copd) is the number 3 killer globally by 2020. copd patients often experience multiple symptoms (e.g. dyspnea, cough, and deteriorating quality of life) and have imposed a substantial economic and social burden on health care. current policy for the prevention and management of long-term conditions focuses on efforts to prevent the onset or slow progression of disease early in the disease trajectory. this prevention paradigm has only recently been adopted for copd. systematic reviews have shown self-management support for patients with copd is effective in improving health-related quality of life and in reducing hospital admissions, but the evidence comes largely from patients with moderate or severe disease and is predominantly recruited from secondary care. simple and systematic strategies are needed to improve out-of-hospital support and management for people living with copd. an instant messaging smartphone app, which allows texts, audio, pictures and video messages to be shared in chat groups, is already available to and is the most popular in the hong kong general public. mobile instant messaging can be conducted through a daily use device to increase access and efficacy, which has been suggested as a feasible approach to delivering an intervention with positive effects on health behaviours and outcomes. text messaging via mobile phones has been shown to be effective in helping promote lifestyle change in diabetes self-management, weight loss, physical activity, smoking cessation and medication adherence with quantitative and qualitative evidence. however, we have not found messaging intervention that was applied in people with copd, except an ongoing study of using instant text message support for patients with chronic respiratory and cardiovascular diseases. hence, the current proposal is to use a quantitative survey and qualitative interview exploring the information needs of copd patients and evaluating the feasibility and acceptability of a smartphone-based instant messaging self-management support program to improve the quality of life in patients with copd.

Eligibility criteria:
inclusion criteria * aged 18 years and above * diagnosis with copd * able to speak and read chinese * able to complete the self-administered questionnaire * mental, cognitive and physically fit determined by the clinician or responsible investigator * signed informed consent exclusion criteria * serious active infection * severe respiratory insufficiency

Keywords: copd self-management support smartphone-based digital
the effect of timing of intravenous paracetamol administration on post-surgical pain

Conditions: Obesity, Morbid

Summary: this study is designed as a population-based prospective randomized cohort study. a prospective cohort of patients admitted to laparoscopic sleeve gastrectomy due to morbid obesity

all adult consecutive patients admitted to surgical departments for laparoscopic sleeve gastrectomy will be enrolled prospectively. for the purposes of the current study we want to determine how much paracetamol (acetaminophen) can reduce the cytokines levels in these patients the study enrollment period is planned to be a year. the follow-up period for each patient will be until discharge from the hospital.

Eligibility criteria:
inclusion criteria: * age ≥18 years * patients admitted for laparoscopic sleeve gastrectomy * elective surgery * bmi \> 40 * american society of anesthesiology classification: 1-2 exclusion criteria: * patients' refusal to participate in the study * patients unable to give an informed consent * pregnancy * emergency surgery * patient with known allergy to paracetamol * patient with hepatic failure * international normalized ratio \>1.7 * albumin\<3.5g/dl * bilirubin \>2mg/dl * patient with fever \> 37.5 ° c * patient with hemoglobin \< 8 * patients chronically treated with steroids or steroid-treated patients over a month in the year preceding surgery. drug addict

Keywords: morbidly obese ,elective sleeve gastrectomy paracetamol iv perfelgan
quality of life after arthroscopic rotator cuff repair

Conditions: Rotator Cuff Tear

Summary: the goal of this longitudinal study is to understand the postoperative quality of life and dynamic trajectory of shoulder function in individuals with rotator cuff tears.

rotator cuff tears (rcts) involve rupture of shoulder tendons or muscles, leading to pain and weakness. its prevalence increases with age and is influenced by factors such as handedness, obesity, and smoking. although conservative treatments are common, surgery aims to restore function. however, limited research has been conducted on postoperative psychological and social changes. patient-reported outcome (pro) and health-related quality of life (hrqol) assessments are gaining importance, offering comprehensive insights into patient experiences. this longitudinal study will include 200 randomized controlled trials (rcts) of patients who undergo surgery. demographics, physical examinations, and scales, such as ases, worc, whoqol-bref, and eq-5d, are collected preoperatively and at 2 weeks and 3, 6, 9, and 12 months postoperatively. mri is used to assess postoperative healing at 6 months. statistical analyses are performed using sas software encompassing chi-square, t-tests, linear mixed effects models, and subgroup analyses to identify determinants of postoperative quality of life and functionality.

Eligibility criteria:
inclusion criteria: -patients were evaluated by orthopedic surgeons as having a rotator cuff tear between august 2021 and july 2022, confirmed by magnetic resonance imaging (mri) or ultrasound. if the patients required surgery and were willing to participate in the trial, the research assistant provided informed consent. exclusion criteria: 1. acromioclavicular arthritis requiring distal clavicular resection. 2. severe glenohumeral arthritis (hamada classification grade 3 or higher). 3. history of shoulder fracture. 4. absolute contraindications to mri, such as claustrophobia, pacemakers, neurostimulators, drug infusion pumps, artificial inner ear implants, and metallic implants.

Keywords: rotator cuff tears quality of life ultrasound mri
react-vascular access her2 negative vascular access strategies for (neo) adjuvant breast cancer treatment without trastuzumab

Conditions: Breast Cancer; Cancer

Summary: in the react-vascular access her2 negative study, the investigator will use a novel method to allow comparisons of established standard of care vascular access strategies using the "integrated consent model" as part of a pragmatic clinical trial. determining the optimal vascular access strategy remains an important medical issue for patients, nurses, physicians and society. a novel method to allow comparison of established standards of care is needed as part of an increasing internationally mandated incentive to perform more pragmatic clinic trials.


Eligibility criteria:
inclusion criteria: * histologically confirmed primary breast cancer * planned to start either fec-d, ac-d, dose-dense ac-t, tac, or tc chemotherapy, in the adjuvant or neoadjuvant setting. * ≥19 years of age * able to provide verbal consent exclusion criteria: • contraindication to central line placement.

Keywords: her2 negative
re-engineering systems for the primary care treatment for ptsd

Conditions: Stress Disorders, Posttraumatic; Depression

Summary: the study is an evaluation of a systemic intervention to enhance the delivery of care according to practice guidelines for posttraumatic stress disorder (ptsd). the immediate objectives are to (1) implement three component model (3cm) in va primary care clinics; and (2) evaluate the effects of 3cm on clinician behavior and patient outcomes. the long-term objectives are to generate information to support implementation research on the respect model for treating ptsd in primary care and ultimately, the implementation of the model in vha to provide care to veterans with ptsd.

3cm consists of (1) a prepared practice, (2) care management, and (3) enhanced mental health support. a prepared practice refers to education for primary care clinicians and office staff about practice guidelines and evidence-based care, the skills needed for use of assessment measures, and the use of communication forms and routines. the education plan consists of predisposing activities, including active teaching and learning, and enabling and reinforcing activities in order to help clinicians use newly acquired skills and to reinforce the continued use of these skills in practice. care management is accomplished by telephone, usually by a centrally located care manager during acute phase treatment and follow up to answer patient questions, promote adherence to the clinician's management plan, and help patients overcome barriers to adherence. enhanced mental health support is provided by a psychiatrist who supervises care managers by telephone, provides informal consultation to primary care clinicians, and helps to increase the quantity or quality of mental health referral resources.

Eligibility criteria:
inclusion criteria: * military veterans in primary care clinics who meet diagnostic criteria for ptsd in one of the 5 sites in texas where this study is being conducted. * must have regular access to a telephone and speak english. exclusion criteria: * cognitive impairment * a history of psychosis or mania * prominent current suicidal ideation * current substance dependence * current engagement in mental health treatment

Keywords: stress disorders, posttraumatic delivery of health care, integrated primary health care veterans depression
effects and safety of taurine granule on blood pressure in prehypertensive

Conditions: Prehypertension

Summary: prehypertension are associated with an increased risk of atherosclerosis and coronary artery disease, and often complicated with the metabolic disorder of glucose and lipid. the comprehensive prevention of hypertension is still an important and complex clinical issue. taurine is one of the ingredients of chinese medicine bezoar ,as an endogenous amino acids is central inhibitory neurotransmitter, can regulate the excitability of nerve tissue, regulate body temperature, therefore, antipyretic, sedative, analgesic, anti-inflammatory,the role of anti-rheumatic, anti-convulsant. in addition, taurine inhibits platelet aggregation in the circulatory system, lower blood lipids, to maintain the body's normal blood pressure and prevent atherosclerosis; protective effect on myocardial cells, can be anti-arrhythmic; special efficacy to lower blood cholesterol, to treat heart failure. the effect of oral taurine on blood pressure is not consistent, however, many animal study has shown that oral administration of taurine, could reduce 24-hour mean arterial systolic and diastolic blood pressure in spontaneous hypertensive rats. furthermore, taurine interfere with calcium and low affinity binding of the calcium binding sites, decrease the voltage-dependent ca2+channel in vascular smooth muscle relaxation, vasodilation, lower blood pressure.in a prospective, double-blind, randomized, and parallel-group study, we will evaluate the effects of taurine granule on blood pressure and metabolic parameters in prehypertensive and mild hypertensive patients. this study will help develop future comprehensive prevention and treatment strategies for hypertension.


Eligibility criteria:
inclusion criteria: * blood pressure: 120mmhg≤sbp\<140mmhg. exclusion criteria: * diabetes * hypertension: sbp≥140mmhg, or dbp≥90mmhg. * known allergy to trial drugs * myocardial infarction or cerebrovascular accident in the year preceding the trial * clinical congestive heart failure * secondary hypertension * pregnancy or lactating women * malignant tumor * gastroesophageal reflux or gastroduodenal ulcer * history of hepatitis or cirrhosis * history of kidney disease * body weight﹤35kg

Keywords: hypertension taurine metabolism
implementing an intervention to foster resident and family engagement in care planning

Conditions: Quality of Life

Summary: this study is a pilot test of an intervention to engage residents and their family and the healthcare team in a collaborative approach to decisions about care planning in long-term care. the intervention includes leadership coaching with the management team, an educational bundle that includes a one-day education session for staff and managers on communication strategies and ways to engage family and residents in care planning and follow-up visits, and a series of resident and family led huddles (brief, 15 minute meetings) to discuss a care related topic with staff to foster proactive communication and information sharing for care planning.

this study is a pilot test of an intervention to engage residents and their family and the healthcare team in a collaborative approach to decisions about care planning in long-term care. the intervention includes leadership coaching with the management team, an educational bundle that includes a one-day education session for staff and managers on communication strategies and ways to engage family and residents in care planning and follow-up visits, and a series of resident and family led huddles (brief, 15 minute meetings) to discuss a care related topic with staff to foster proactive communication and information sharing and care planning. the study aims are to describe the feasibility and acceptability of the resident and family engagement intervention, and to evaluate the following outcomes: resident quality of life, resident and family satisfaction with care, and staff quality of work life. the investigators aim to recruit 20 staff, the leadership team, and 12 resident-family dyads from four long-term care facilities who will receive the intervention and complete the survey measures. the expected outcome from this study is an increased understanding of how to engage residents and family in care decisions impacting quality of life. amendment: due to the covid-19 pandemic, the anticipated sample size is smaller and as a result, our outcomes will be explored qualitatively through interviews.

Eligibility criteria:
inclusion criteria for residents: * residents who can communicate in english * residents (aged 65 or older) who have a visiting family member who is their substitute decision maker- both the resident and their family member will participate in the huddles exclusion criteria: * residents with severe cognitive impairment * residents who do not speak english