Kornimate/medical-research-clean huggingface dataset:
impact of chronic air pollution on non-cystic fibrosis bronchiectasis

Conditions: Bronchiectasis

Summary: we aim at investigation the impact of chronic air pollution exposure on non-cystic fibrosis bronchiectasis outcome.

* patient files will be search for time of death and cause of death. * other variables will be collected: bacterial culture results, therapy, gender, age, etc. * these data will be linked with pollution data: trafic load, distance to major road, etc.

Eligibility criteria:
inclusion criteria: * hrct diagnosis of bronchiectasis * recurrent infections or chronic sputum production * patients between 18 and 65 years old. exclusion criteria: * cystic fibrosis * tumoral disease * traction bronchiectasis due to interstitial lung disease * patients older than 65 years or younger than 18 years at recruitment * copd

Keywords: non-cystic fibrosis bronchiectasis
home bp monitoring

Conditions: High Blood Pressure

Summary: most cases of high blood pressure in teens are missed for a number of reasons. one reason is that the most common way to make a diagnosis is to make three or more blood pressure measurements in a doctor's office on separate days. this can be inconvenient. also, measuring blood pressure in the office might be inaccurate, since children (including teens) might have high values in the office but normal values at home. for these reasons, investigators wish to study a different way to identify teens with high blood pressure. home bp measurements have been used in europe to make a diagnosis, but not yet in the united states, and never in a higher risk population of teens. african american teens are at higher risk for high blood pressure than other teens. investigators will compare the values received from the home bp machines to another method (24 hour ambulatory bp monitoring or abpm) which is the best standard for diagnosis. investigators also want to learn more about participants experience and their child's experience with both methods. a small sample of participating teens and parents will be invited to participate in short telephone interviews. this study plans to enroll a total of 750 teens at uh. recruitment will not take place from other organizations.


Eligibility criteria:
inclusion criteria: * self-identify or identified by a parent as african-american or of partly african american ancestry exclusion criteria: * prior hypertension diagnosis * prescribed bp medication * history of congenital heart disease * history of solid organ transplant * prescribed and using stimulants and other medications on a regular basis known to raise blood pressure such as testosterone and nicotine replacement

Keywords: african american teen home blood pressure monitoring
psovac: educational needs re vaccines for biologic patients with psoriasis

Conditions: Psoriasis; Covid19

Summary: to determine if there is a need for further education on vaccines with psoriasis patients who are on a biologic. in regards to the covid-19, it is important that psoriasis patients - whether on a biologic or not - understand whether they can have certain vaccines. that will depend on the type of vaccine that becomes available.


Eligibility criteria:
inclusion criteria: * psoriasis patient exclusion criteria: * no exclusions

Keywords: education vaccine biologic
adverse drug reactions to anti-tb drugs in the treatment of latent tuberculosis infection

Conditions: Latent Tuberculosis Infection

Summary: the investigators aim to study the prevalence of adverse reactions of anti-tuberculosis (tb) drugs in latent tuberculosis infection (ltbi), and determine the risk factors of anti-tb drug-related toxicity in ltbi in korean health care workers(hcws).

further study details as provided by hanyang university hospital this study is prospective study of newly diagnosed ltbi in hcws at hanyang university hospital, a tertiary referral hospital in south korea, between 2017 and 2018. this study aimed to identify the prevalence of adverse reactions of treatment regimen for ltbi. the diagnosis of ltbi was made on the basis of interferon-gamma releasing assay. information on demographic characteristics, comorbidity and treatment outcomes was collated from questionnaires. treatment regimen for ltbi was chosen by patients' preference among 3 months of inh(isoniazid) plus rfp(rifampin), 4 months of rfp and 9 months of inh. all ptb patients were observed 2 weeks after the initiation of medication, and monthly thereafter, and were asked about any drug side effects at these visits. serious adverse drug reaction (adr) was defined as any severe side effect that resulted in discontinuation or change (either temporally or permanently) of anti-tb medication, and/or directly resulted in hospitalization. drug-induced hepatitis was defined as liver transaminases more than three times higher than the upper limit of normal in the presence of symptoms such as anorexia, nausea, vomiting, or abdominal pain, or transaminases more than five times the upper limit of normal without symptoms.

Eligibility criteria:
inclusion criteria: * 19 years or more * identified latent tuberculosis infection (ltbi) in korean health care workers, using whole-blood interferon-r release assays exclusion criteria: * subjects who do not want to participate the present study * subjects who do not receive ltbi treatment due to abnormal liver function test (i.e, liver cirrhosis etc) * subjects with history of previously treated tb * subjects with active tuberculosis infection

Keywords: adverse drug reaction latent tuberculosis infection tuberculosis
n-acetyl cysteine effect in peripheral neuropathy in cancer patients

Conditions: Peripheral Neuropathy Due to Chemotherapy

Summary: the purpose of the study is to evaluate the effect of n-acetyl cysteine in combination with paclitaxel on the clinical outcomes of patients with peripheral neuropathy, paclitaxel-induced peripheral neuropathy affect quality of life in cancer patients. new therapeutic approches such as the antioxidant n-acetyl cysteine, showed to has neuroprotective effect, the aim of the study is to evaluate the effect of n- acetylcysteine(nac) administration in the prevention of paclitaxel-induced peripheral neuropathy.

paclitaxel is a first-line chemotherapeutic treatment of solid tumors. neuronal damage also seems to have a major role in paclitaxel-induced neuropathic pain, paclitaxel contributes to ros formation (superoxide, hydroxyl radical, nitric oxide and hydrogen peroxide) in neuronal mitochondria that are involved in nerve injury-induced. n-acetylcysteine (nac) is a cysteine pro-drug and glutathione (gsh) precursor which is a protective agent and detoxifies and scavenges reactive oxygen species (ros), which seems to help normalize the oxidative status. it has been reported that high dose of n-acetylcysteine shown to prevent retrograde motor neuron death after neonatal peripheral nerve injury and significantly increases motor neuron survival, which may improve functional outcomes after obstetrical brachial plexus injury in rats. also, it has been reported that nac significantly inhibited cci-induced microglia activation but elicited no notable effects on astrocytes. these results demonstrate an effective and safe approach that has been used clinically to alleviate neuropathic pain via the powerful inhibition of the activation of mmps in rats. n-acetylcysteine has been shown to have neuroprotective effects against oxaliplatin-based adjuvant chemotherapy in colon cancer patients with oral administration of n-acetylcysteine1,200 mg) was given one and a half hours before each oxaliplatin administration.

Eligibility criteria:
inclusion criteria: 1. adult patients (\>18 years old). 2. breast cancer patients who will receive adjuvant weekly paclitaxel for 12 cycles. 3. ecog performance status 0-2 4. adequate bone marrow function (white blood count ≥4,000/mm3, platelet count ≥100,000/mm3), liver function (serum total bilirubin \<1.5 mg/dl), renal function (creatinine \<1.5 mg/dl). exclusion criteria: 1. patients who have any of the following: * clinical neuropathy. * diabetes mellitus. 2. patients receiving vitamin b1, b6, b12,or other vitamin supplemental therapy. 3. patients receiving antidepressants, opioids, adjuvant analgesic agents (eg, anticonvulsants, clonazepam, or mexiletine), topical analgesics, and amifostine. 4. hypersensitivity to nac.

Keywords: paclitaxel peripheral neuropathy n-acetyl cysteine
local anaesthetic infusion for laparoscopic hysterectomy

Conditions: Postoperative Pain

Summary: more hysterectomies are performed laparoscopically either as a total laparoscopic hysterectomy or as a laparoscopically assisted vaginal hysterectomy. the advantages of laparoscopic surgery include quicker hospital discharge, a shorter convalescence and cost effectiveness when compared to open procedures. laparoscopic hysterectomies (both total and vaginally assisted) can lead to discomfort which may lead to a delay in discharge from hospital. continuous infusions of local anaesthetic agents given post operatively to the site of operation have the been subject of trials for several operative procedures. to date however there have not been any properly controlled studies evaluating whether there are benefits of giving a local anaesthetic infusion for 48 hours into the pelvis following a total or vaginally assisted laparoscopic hysterectomy. the investigators therefore propose to investigate whether giving a local anaesthetic infusion in this fashion decreases the amount of rescue and patient controlled analgesia needed, and length of hospital stay. in order to do this the investigators wish to conduct a randomised placebo controlled double blind trial.


Eligibility criteria:
inclusion criteria: all women undergoing a total laparoscopic or laparoscopically assisted vaginal hysterectomy exclusion criteria: women undergoing surgery for cancer, or are known to be allergic to local anaesthetic agents.

Keywords: pain anaesthetic
study to evaluate the safety, tolerability, and efficacy of cilofexor in adults with primary biliary cholangitis without cirrhosis

Conditions: Primary Biliary Cholangitis

Summary: the primary objective of this study is to evaluate the safety and tolerability of cilofexor in adults with primary biliary cholangitis (pbc).


Eligibility criteria:
key inclusion criteria: * meets all of the following conditions * definite or probable pbc as defined by at least 2 of the 3 following criteria: * serum alkaline phosphatase (alp) \> the upper limit of normal (uln) * presence of anti-mitochondrial antibodies (ama) in serum (≥ 1:40 on immunofluorescence) * liver histological findings consistent with pbc including nonsuppurative, destructive cholangitis affecting mainly the interlobular bile and septal bile ducts * serum alp \> 1.67 x uln and/or total bilirubin \>uln but ≤ 2 x uln * ursodeoxycholic acid (udca) use at a stable dose for at least 12 months or intolerant of udca with no udca use for at least 12 months before screening * screening fibrosure/fibrotest® \< 0.75 unless a historical liver biopsy within 12 months of screening does not reveal cirrhosis. in adults with gilbert's syndrome or hemolysis, fibrosure/fibrotest will be calculated using direct bilirubin instead of total bilirubin. key exclusion criteria: * alanine aminotransferase (alt) \> 5 x uln * total bilirubin \> 2 x uln * international normalized ratio (inr) \> 1.2 unless on anticoagulant therapy * other causes of liver disease including viral, metabolic, alcoholic, and other autoimmune conditions. participants with hepatic steatosis may be included if there is no evidence of nonalcoholic steatohepatitis (nash) in the opinion of the investigator or on liver biopsy. * use of fibrates or obeticholic acid within 3 months prior to screening through the end of treatment * cirrhosis of the liver as defined by any of the following: * historical liver biopsy demonstrating cirrhosis (eg, ludwig stage 4 or ishak stage ≥ 5) * history of decompensated liver disease, including ascites, hepatic encephalopathy or variceal bleeding * liver stiffness \> 16.9 kpa by fibroscan® note: other protocol defined inclusion/exclusion criteria may apply.
daptomycin in the treatment of patients with renal insufficiency and complicated skin and skin structure infections

Conditions: Soft Tissue Infections

Summary: this is a phase 4, randomized, open-label, multicenter, comparative study designed to further evaluate the pharmacokinetics of intravenous (i.v.) daptomycin and the safety and efficacy of daptomycin relative to comparator in the treatment of complicated skin and skin structure infections in patients with renal impairment.


Eligibility criteria:
inclusion criteria: - moderate to end-stage renal impairment - a diagnosis of complicated skin and skin structure infection known or suspected to be due to susceptible gram-positive bacteria based on positive gram stain - a diagnosis of bacterial skin and skin structure infection in the presence of some complicating factor exclusion criteria: - known bacteremia, osteomyelitis or endocarditis

Keywords: renal impairment daptomycin cubist complicated skin and skin structure infections
immunogenicity and safety of a tetanus-diphtheria vaccine and a 13-valent pneumococcal conjugate vaccine

Conditions: Tetanus; Diphtheria; Pneumococcal Infections

Summary: when two or more vaccines are administered concurrently, there is a concern on vaccine interaction, which can either enhance or suppress immune response to vaccine antigens. this study is designed to evaluate the immunogenicity and safety of tetanus-diphtheria (td) and pneumococcal vaccines after concomitant administration in adults aged 50 years and older.

vaccination would be the most effective strategy to prevent diverse infectious diseases. actually, the world health organization (who) estimate that vaccination averts 2-3 million deaths per year. in adults, several vaccines are recommended based on age and medical conditions if they have not receive vaccination before, and lack evidence of past infection: influenza, measles-mumps-rubella (mmr), varicella, human papilloma virus (hpv), tetanus-diphtheria (td), pneumococcl vaccines and etc. in particular, when the patient visits a vaccination clinic, td and the pneumococcal vaccines are commonly administered at the same time. in this study, we aimed to evaluate the immunogenicity and safety of td vaccine and pcv13 after concomitant administration in adults aged 50 years. this single-center, open label randomized trial was conducted (clinical trial number - nct02215863) at korea university guro hospital from november 2013 to april 2016. adults ≥50 years of age were randomized in a 1:1:1 ratio to receive td + pcv13 (group 1), pcv13 alone (group 2) or td alone (group 3).

Eligibility criteria:
inclusion criteria: * adults aged ≥50 years who signed the informed consent exclusion criteria: * history of s. pneumoniae infection within the previous 5 years * previous pneumococcal vaccination * previous tetanus-diphtheria (td) vaccination within the last 10 years * known immunodeficiency or immunosuppressant use or coagulation disorders
the effect of yoga on barriers to occupational engagement in african american breast cancer survivors

Conditions: Breast Neoplasm Female

Summary: the purpose of this study was to determine if occupational therapy informed yoga could decrease barriers to occupational engagement in african american breast cancer survivors. .

breast cancer disproportionately affects african american women as illustrated by a 42% higher death rate and an 11% lower 5-year survival rate when compared to caucasian women. reasons for these disparities include biological and structural barriers to higher survival rates. regular physical activity and resistance training are recommended to support improved survivorship. to date, few efforts have targeted african american survivors who may experience greater survivorship challenges than caucasians. yoga is a safe and effective means for breast cancer survivors to exercise and gain positive physical and psychosocial outcomes. only two studies, 10 years apart, have provided evidence about the efficacy of yoga for african american breast cancer survivors.

Eligibility criteria:
inclusion criteria: * african american race * breast cancer survivor * no medical restrictions on activity exclusion criteria: * race other than african american * no history of breast cancer * medical restrictions on activity

Keywords: yoga
effect of weight reduction and aerobic exercise on pms symptoms in obese females

Conditions: Premenstrual Syndrome

Summary: the purpose of this study will be investigation of the effect of weight reduction and aerobic exercises on premenstrual syndrome symptoms in obese females.

both groups (a\&b) will take their medical treatment in the form of (nsaids) and the study group b will under go a siet plan which will fits the participants. diet plan extends for 12 weeks in the form of caloric restriction program and each woman in group b will perform aerobic exercise program, in the form of treadmill 3 times/week for 8 weeks for 12 weeks. each session will take about 30 minutes as the following: 5 minutes warming up exercises by walking on the treadmill by low speed, 20 minutes walking at moderate intensity (70% of the maximal heart rate) and 5 minutes are cooling down by walking on the treadmill by low speed as in warming up.

Eligibility criteria:
inclusion criteria: * age will range between 20- 30 years old. * only females will participate in the study. * all patients who will be enrolled to the study will have their informed consent. exclusion criteria: * diabetes mellitus. * individuals with cardiopulmonary conditions. * individuals with any pelvic disease. * individuals undergoing radiation therapy or chemotherapy. * hepatic or pancreatic diseases.

Keywords: "premenstrual syndrome" "diet" "exercise" "obesity"
safety and efficacy registry of yinyi stent

Conditions: Coronary Artery Disease

Summary: drug-eluting stents effectively reduce restenosis but may increase late thrombosis and delayed restenosis. persistent polymer could be responsible. local delivery of paclitxel from a polymer-free yinyi stent (dalian yinyi biomaterial research and development co.ltd) may prevent these complications.


Eligibility criteria:
inclusion criteria: * age 18-80 years old * both gender * native coronary lesion * narrowing \> 70% * vessel size 2.5-4.0 in diameter exclusion criteria: * without informed consent, * st elevation myocardial infarction within 7 days, * patient with ≤ 70% coronary narrowing at target lesion, * left main lesion, * multivessel narrowing need more than 3 stent implantations, * by-pass graft, * abnormal liver function before randomization, * active hepatitis or muscular disease, * impaired renal function with serum creatinine level \> 3mg/dl, * impaired left ventricular function with lvef \< 30%, * participate in other studies.
single shot vs continuous interscalene block for rotator cuff repair

Conditions: Pain; Rotator Cuff; Surgery

Summary: 1. rotator cuff have painful post surgery recovery. 2. single shot interscalene with oral analgesics may or may not be enough 3. continuous nerve block may be too much for the surgery 4. the idea is to compare two techniques to see if the two techniques can improve patient pain control and satisfaction.

after consent patients will be randomized to one of the two groups: control group or the experimental group. patients will be blinded to the group assignment. in the control group the patient will be given single shot interscalene block using ultrasound technique following established guidelines. the procedure will be done after starting intravenous access and placing standard anesthesia monitors (ekg, blood pressure cuff and pulse-ox) on the patient. following accepted aseptic guidelines the nerves will be visualized at the base of the neck using ultrasound machine. once proper nerve roots or trunks visualized 3 mg/kg of 0.5 % bupivacaine will be injected in small blouses. in the experimental group, after placement of monitors, the nerves will be visualized using ultrasound machine. there after a catheter will be placed. they subjects will be dosed using 0.5% bupivacaine 3 mg/kg for the surgery via the catheter. the extent of block before the surgery will be evaluated at 30 minutes post injection. surgery will be done with sedation. conversion of anesthetic technique to general anesthesia will be considered failure of the technique to provide adequate surgical anesthesia. at the end of the case the patient will be taken to recovery and will be evaluated for pain. if patient is having pain of 3 or more then they will be treated as follows. in single shot group will be offered to be blocked again or treated with oral narcotics. in the catheter group patient will be dosed with 10 ml 1% lidocaine. if it fails to provide any relief then the catheter will be pulled back and another 10 ml1% lidocaine will be given. if still not effective then it will be replaced. refusal of patient to replace the catheter will result in patient dropping out of the study. working catheter will be left in place for at least 48 hrs. patients will be allowed to take oral pain medicines as prescribed by their surgeons. the patient will be sent home with pain pump to continuously give them 0.125% bupivacaine at 5 ml per hr with an option to get extra dose of 5 ml q hr if needed. the pain control will be monitored by phone daily till catheter comes out.

Eligibility criteria:
inclusion criteria: * adult * rotator cuff surgery * agreeing to regional block for pain control exclusion criteria: * pregnancy * neuropathy * any allergies to local anesthetics * any contraindication to nerve blocks

Keywords: continuous block single shot interscalene rotator cuff surgery
testing hypersensitivity to metals in sarcoidosis patients by applying the melisa test.

Conditions: Sarcoidosis

Summary: the purpose of this study is to apply the melisa test, that diagnose hypersensitivity to metals, in sarcoidosis patients with occupational exposure.

peripheral blood from sarcoidosis patients with occupational anamnesis that involves exposure to metals will be sent to melisa medica in stockholm sweden. the melisa test will examine hypersensitivity to metals that can be related to the granulomatous response of sarcoidosis.

Eligibility criteria:
inclusion criteria: biopsy confirmed sarcoidosis granulomatous disease occupational anamnesis with exposure to metals exclusion criteria: patients with interstitial disease no occupational anamnesis

Keywords: sarcoidosis occupational exposure melisa