early diagnosis of ards in mechanically ventilated patient using lus score in comparison with ct

Conditions: Acute Respiratory Distress Syndrome; Mechanical Ventilation Complication; Computed Tomography

Summary: the aim of this study is to assess accuracy of lung ultrasound score for early diagnosis of acute respiratory distress syndrome in patients who expected to be mechanically ventilated more than 24 hour in comparison with computed tomography chest .

acute respiratory distress syndrome is an acute, diffuse, inflammatory form of lung injury and life-threatening condition in seriously ill patients, characterized by poor oxygenation, pulmonary infiltrates, and acute onset. on a microscopic level, the disorder is associated with capillary endothelial injury and diffuse alveolar damage acute respiratory distress syndrome is an acute disorder that starts within seven days of the inciting event and is characterized by bilateral lung infiltrates and severe progressive hypoxemia in the absence of any evidence of cardiogenic pulmonary edema. according to the berlin definition, acute respiratory distress syndrome is defined by acute onset, bilateral lung infiltrates on chest radiography or computed tomography scan of a non-cardiac origin, and a pao2/fio2 ratio of less than 300 mm hg. the berlin definition differs from the previous american-european consensus definition by excluding the term acute lung injury; it also removed the requirement for wedge pressure \< 18 mm hg and included the requirement of positive end-expiratory pressure or continuous positive airway pressure of greater than or equal to 5 cm h20. once acute respiratory distress syndrome develops, patients usually have varying degrees of pulmonary artery vasoconstriction and may subsequently develop pulmonary hypertension. acute respiratory distress syndrome carries a high mortality, and few effective therapeutic modalities exist to combat this condition although the berlin definition of acute respiratory distress syndrome was a major step forward, some of its limitations were recognized soon after publication. specifically, it was recognized that its requirement for noninvasive ventilation or invasive ventilation could not be met in settings in which these modalities are not available so consensus conference of 32 critical care develop new global acute respiratory distress syndrome definition that use high flow nasal oxygen , pulse oximetry in place of arterial blood gas and use of lung ultrasound to suit limited resource setting . lung computed tomography scan is the gold standard in diagnosis of acute respiratory distress syndrome can provide useful diagnostic information and assess the benefit of treatment. however, this procedure is done in a computed tomography unit under cardiorespiratory monitoring with an increased risk to the patient. diagnostic and lung exploratory ultrasound is a rapidly evolving technique used in the intensive care unit environment, being considered noninvasive, radiation-free, cheap, and easy to perform . lung ultrasound has been validated for hemodynamic management, pleural effusions, pulmonary edema, pneumothorax detection, parenchymal consolidation, and central vein catheter placement . simple and short lung ultrasound examination could predict prone position oxygenation response in acute respiratory distress syndrome patients . scores based on detection of b-lines (the sonographic sign of increased lung density associated with interstitial syndrome) and on consolidation have been correlated with global and regional lung aeration as assessed by computed tomography chest. lung ultrasound has been proposed as an accurate bedside and radiation free technique for evaluation of lung consolidations and for follow-up of aeration changes in response to interventions. however lung us scoring system hasn't been included in acute respiratory distress syndrome definition and didn't prefer image modality in diagnosis of acute respiratory distress syndrome , therefore our study will explore the feasibility and accuracy of lung us score performed bedside to differentiate between acute respiratory distress syndrome and non acute respiratory distress syndrome patient compared to lung computed tomography .

Eligibility criteria:
inclusion criteria: * patients aged more than 21 years old of both sexes . * patients who are expected to be mechanically ventilated more than 24 h . * patients who are suspected to be acute respiratory distress syndrome according to berlin definition which consists of clinical criteria and with precipitating factors which starts within 1 week of known insult as in trauma patients with lung contusions. exclusion criteria: * patient's first guardian who refuse the inclusion in the study . * history of pre-existing lung disease ( tumors, interstitial lung diseases) * in cases of volume overload. * patients with acute kidney injuiry or renal failure