Kornimate/medical-research-clean huggingface dataset:
reducing risk of stroke and dementia in patients with covert cerebrovascular disease

Conditions: Covert Cerebrovascular Disease

Summary: the purpose of the discover study is to pilot acceptable approaches to people with covert cerebrovascular disease (ccd) and their follow-up. this is the first step in designing efficient randomised trials of treatments to reduce the risk of stroke or dementia in people with ccd.

discover is a prospective cohort involving individuals with covert cerebrovascular disease (ccd) in nhs lothian. participants will be recruited through electronic health records and clinician collaborators. participants will be monitored at 3 and 6 months and where possible 12 months to assess cognitive, functional, and vascular event outcomes.

Eligibility criteria:
inclusion criteria: * people who, at the time the letter is prepared or are identified by a clinician * age ≥ 65 years * have no known history of: * stroke or tia * dementia * parkinson's disease * multiple sclerosis * metastatic cancer (or non-meningioma brain tumour). * a ct or mri scan report ≤5 years before study start date with of one or more of: * cerebral small vessel disease * deep old ischaemic stroke * cortical old ischaemic stroke exclusion criteria: * text of brain scan report unreadable * do not consent to take part in study procedures * unable to consent * unable to communicate by email, letter or telephone through language, speech disability or lack of address * unlikely to survive one year past enrolment in judgement of the study investigator

Keywords: ccd
safety and efficacy of adipose derived stem cells for chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this will be an open-label, non-randomized multi-center study designed to assess the safety and efficacy of adipose-derived stem cell (asc) iv implantation. the therapy is composed of cells isolated from a patient's own adipose tissue. liposuction will be performed to collect the adipose tissue specimen for subsequent processing to isolate the stem cells.

in the context of the proposed study, adipose derived stem cells (asc) constitute an autologous cell product that is delivered to the patient via intra-venous injection. in this study, we propose to investigate the immunosuppressive potential of the non-manipulated non-cultured stromal vascular fraction obtained via liposuction. endpoints will be measured both by improvement of the forced evacuation volume in one second (fev1) and distance covered in a 6 minute walk distance test (6mwd). the stromal vascular fraction comprises stromal cells isolated from total fat via enzymatic digestion ex-vivo. these cells are not cultured but are isolated from adipose tissue using a sterile tissue process in under two hours. the process includes rinsing in a saline solution to remove red blood cells, draining, and enzymatic digestion (collagenase) which isolates endothelial cells from adipose tissue. post-processing, the pellet obtained via centrifugation is filtered and delivered to the patient who remains sedated within the same ambulatory center.

Eligibility criteria:
inclusion criteria: * age 18 to 85, inclusive * a prior diagnosis of moderate to severe copd * gold iia, iii, iv exclusion criteria: * pregnant or lactating * life expectancy \< 6 months due to concomitant illnesses. * exposure to any investigational drug or procedure within 1 month prior to study entry or enrolled in a concurrent study that may confound results of this study. * any illness which, in the investigators judgment, will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of study results * subjects on chronic immunosuppressive or chemotherapeutic therapy * known drug or alcohol dependence or any other factors which will interfere with the study conduct or interpretation of the results or who in the opinion of the investigator are not suitable to participate. * subjects with alpha-1 antitrypsin deficiency (an inherited disorder that can cause lung disease and liver disease). * unwilling and/or not able to give written consent * patient is positive for hepatitis (past history of hepatitis a is allowed) * any medical condition, which in the opinion of the clinical investigator, would interfere with the treatment or outcome of the patient * cerebral aneurysm clips

Keywords: copd
tricuapid annular plane sistolic excursion before general anesthesia can predict hypotension after induction

Conditions: Anesthesia

Summary: the investigators purpose is to predict hypotensive condition that can develop after general anesthesia induction by measuring the tricuspid annular plane systolic movement (tapse), which is an echocardiographic parameter.

intraoperative hypotension development might increase myocardial damage, acute kidney damage, and septic complications, and have an effect on mortality increase. for this reason, prevention of an unwanted hypotensive event has an important role in reducing mortality and morbidity. the prediction of the risk of hypotension is generally based on the evaluation of the comorbid status and volume status of patients .it is already known that right ventricular systolic dysfunction has prognostic value in various pathological cases. it is quite difficult to evaluate the rv function with echocardiography because of the complex geometry of rv. although rv function has been evaluated only visually for many years, guidelines have been published as a result of recent studies by the american society of echocardiography. in this respect, abnormal rv function should be suspected when one of the criteria of s '\ 0.55. normal and abnormal function is distinguished more reliably when combining more than one rv function measures. tapse is a parameter with which the apex-basal shortening can be easily measured, providing specific data on global rv function. it depends less on optimal image quality than other rv function measurements, and is an easy-to-measure criterion. low tapse is not very common; however, it was measured in people with no heart disease due to diagnostic misclassification and excessive ends of the normal spectrum. the investigators think that despite the lack of cardiac disease, cardiac reserve functions of each patient may have limits in terms of development of hypotension in general anesthesia induction. the investigators considered that tapse, which decreased within normal limits in patients without cardiac disease, could predict hypotension development in general anesthesia induction, and planned study for this purpose.

Eligibility criteria:
inclusion criteria: * patients scheduled for elective surgery * patients who will receive general anesthesia * patients between 18-65 years of age * physical status i or ii according to the american society of anesthetists (asa) in preoperative evaluation * those without known heart disease * patients with tapse value above 1.6 cm exclusion criteria: * patients under the age of 8 and over 65, * pregnant patients, * patients who refuse to participate in the study, * asa iii and above, * patients with known heart disease, * patients with tapse value of less than 1.6 measured with transthoracic echocardiography will not be allowed to be included in the study. * patients with difficult airway management or difficult intubation will be excluded from the study.

Keywords: general anesthesia tricuspid anular plane systolic excursion hypotension
pharmacokinetic and pharmacodynamic interaction study of digoxin and hawthorn

Conditions: Heart Diseases

Summary: hawthorn (crataegus oxyacantha) is a natural product that is popular in european and american herbal medicine practice. some of its cardiac uses include the treatment of high and low blood pressure, rapid heart beat, chest pain, and blocked arteries. in many cases, it is used as an adjuvant agent with other cardiac drugs such as digoxin, amiodarone, and warfarin. to date, little information is known about the effect of hawthorn when taken with other drugs and if toxicities occur when hawthorn is used with other drugs. the purpose of this study is to examine the interaction between digoxin and hawthorn in eight healthy subjects. subjects will be recruited by advertisement. the design of the study will include a 10-day and a three-week treatment phase of digoxin 0.125 mg - 0.25 mg/day and hawthorn (crataegus special extract ws1442, schwabe co.) 450 mg twice daily or placebo, with a randomized crossover. there will be a three-week washout period in between treatment phases. on day 10 (phase i) and day 21 (phase ii), subjects will have 12 blood samples drawn for pharmacokinetic analysis. the plasma samples will be measured for digoxin concentration. additionally, the subjects will be assessed for any clinical toxicities or adverse events. the significance of this study is to provide the clinician with information regarding the safe use of digoxin in combination with the herbal supplement, hawthorn.


Eligibility criteria:
inclusion criteria: * healthy adult * not regularly taking any prescription or non-prescription medications (including natural products or supplements) and is willing to avoid all medications other than the study drugs during the study period. * willing to avoid drinking any alcohol throughout the study period. * does not currently smoke and is willing to avoid smoking during the study period. * willing to adhere to dietary restrictions as required during the study.

Keywords: digoxin effect modifiers (epidemiology) rosales drug interaction
comparison of different treatment methods for gait rehabilitation of sub-acute post stroke patients with dropped foot

Conditions: Dropped Foot

Summary: the investigators hypothesize that the gait pattern of following the utilization of a functional electrical stimulation device will be much improved when compared to the effect of regular gait re-education with ankle-foot-orthosis (afo) fitting in patients in early stages following stroke.


Eligibility criteria:
inclusion criteria: * sub-acute stroke patients suffering a first stroke with clinical presentation, according to the who definitions * patients suffering from unilateral foot drop * independent ambulation before the stroke * cognitive and cooperative ability to follow simple instructions * neurological condition severity mild to moderate (between 3 and 15, according to the national institutes of health stroke scale; nihss). * ability to walk with or without a walking aid (cane, walker), with or without assistance. functional ambulation classification (fac) of at least 2 * independently capable to understand an informed consent form. exclusion criteria: * cognitive disorders preventing the subject from understanding the trial protocol or following the researcher's instructions * orthopaedic injury to the paretic or non-paretic limbs * motor disability due to neurological diagnosis, e.g. multiple sclerosis, cerebral palsy, spinal cord injury, and parkinson * peripheral injury of the peroneal nerve or sciatic nerve * pregnant or nursing females

Keywords: functional electrical stimulation (fes) sub acute stroke gait analysis
periodontal therapy in coronary artery patients

Conditions: Cardiovascular Diseases; Atheroma; Coronary Artery Disease

Summary: gingival inflammation has been associated with cardiovascular diseases, including heart attack and stroke, because of elevation of blood risk markers such as cholesterol, glucose and c reactive protein. the treatment of gingival diseases decreases the concentration of these risk factors in the blood of cardiovascular patients.


Eligibility criteria:
inclusion criteria: * 35 years and older * coronary artery disease * more than 10 teeth * chronic periodontitis defined as 2 non-adjacent teeth with probing depth 5+mm and periodontal attachment loss 4+mm exclusion criteria: * use of antibiotics in the last 6 months * periodontal therapy in the last 12 months

Keywords: coronary artery disease c reactive protein periodontitis periodontal therapy flow-mediated dilation
study of nanodox hydrogel vs placebo for dehisced surgical wounds

Conditions: Dehisced Surgical Wounds

Summary: the purpose of this study is to determine the effects of nanodox hydrogel versus placebo hydrogel on dehisced surgical wounds.


Eligibility criteria:
inclusion criteria: * be 18 years of age or older * women of childbearing potential must have a negative urine pregnancy test at screening and at baseline, and: * agree to use a double-barrier method of contraception during their participation in this study; * condoms (with spermicide) and hormonal contraceptives or * condoms (with spermicide) and intrauterine device or * intrauterine device and hormonal contraceptives or * abstains from sexual intercourse during their participation in this study or * is with a same-sex partner and does not participate in bisexual activities where there is a risk of becoming pregnant * have a full-thickness dehisced surgical wound that is between 1.2cm2 and 4 cm2 at initial screening * be able to apply study drug to their wound, or have a reliable and capable caregiver do it * subjects will have adequate blood flow to the wound as defined by transcutaneous oxygen tension (tcpo2) of \>30mmhg recorded over intact epidermis at the dehisced surgical wound margin * non-infected (quantitative bacterial count of \< 1.0 x 105 cfu) exclusion criteria: * less than 18 years of age * pregnant or lactating woman or a female of childbearing potential who is not practicing acceptable form of birth control * allergic to tetracycline, minocycline, demeclocycline, or any other known tetracycline derivative * tested positive for a doxycycline-resistant infection * have undergone treatment with system corticosteroid or immunosuppressive therapy in the past 2 months * currently undergoing dialysis for renal failure * have participated in another clinical research trial within the last 30 days * subject has wounds resulting from any cause other than surgical intervention (diabetes, electrical burn, arterial insufficiency, chemical or radiation insult) * active or previous (within 60 days prior to the study screening visit) chemotherapy * active or previous (within 60 days prior to the study screening visit) radiation to the affected wound area to be treated by investigational drug or placebo * physical or mental disability or geographical concerns (residence not within reasonable travel distance) that would hamper compliance with required study visits * the investigator believes that the subject will be unwilling or unable to comply with study protocol requirements standard-of-care self-care requirements, and all study-related follow up visit requirements * history of sickle cell anemia * history of infection with human immunodeficiency virus * history of other immunodeficiency disorders * severe anemia - hgb \< 10 g/dl (males) or \< 9 g/dl (females) * severe malnutrition (albumin \ 10% weight loss in preceding 6 weeks) * subjects that the investigators deems unstable and/or require intensive monitoring
effects of exercise interventions in frail middle-aged and older adults

Conditions: Frailty

Summary: this study aimed to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and mental functions.

exercise has been suggested as a possible lifestyle intervention for improving physical and cognitive performance. various training options depending on various physical circumstances will be presented. however, the ideal exercise protocol for frail middle-aged and older adults had the greater benefits remain unknown. in general, 3-6 months of frequent exercise can enhance physical and cognitive outcome. the investigators conduct this multiple arm, prospective study to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and cognitive functions. this study designed to recruit 200 older adults with frailty. all the older adults will receive exercise training using either elastic band, dumbbells, machines, treadmill, cycling for 6 months. outcome measures including a systematic evaluation for frail older persons using comprehensive geriatric assessment, as well as the assessments of physical and cognitive functions before and after interventions.

Eligibility criteria:
inclusion criteria: * patients aged above 50 years old with frailty syndrome exclusion criteria: * acute illnesses, such as unstable cardiac dysrhythmia, sepsis, or unstable vital signs * physical or cognitive issues that make it difficult for the patients to participate in our program

Keywords: exercise frailty physical function mental function aged
construction and application of database of hebei provincial gastric cancer collaborative network driven by artificial intelligence technology

Conditions: The Study Focuses on Gastric Cancer

Summary: this clinical trial aims to construct and apply a collaborative network database for gastric cancer in hebei province, driven by artificial intelligence (ai) technology. the project seeks to integrate clinical data, genomic information, and treatment outcomes from multiple hospitals and research centers within the region. by leveraging advanced ai algorithms, the database will facilitate comprehensive data analysis to identify novel biomarkers, optimize therapeutic strategies, and improve patient outcomes. this initiative will also support real-time data sharing and collaboration among healthcare providers, researchers, and policymakers, ultimately enhancing the overall management and treatment of gastric cancer in hebei province.


Eligibility criteria:
inclusion criteria: all patients with gastric cancer exclusion criteria: none
transthoracic shear-wave ultrasound elastography

Conditions: Elasticity Imaging Techniques

Summary: this study aims to provide the information of tissue elasticity in different etiologies of pulmonary lesions and to validate the predictive value of shear-wave elastography in differentiating benign pulmonary lesions from malignant lesions.


Eligibility criteria:
1. inclusion criteria: (1) retrospective cohort from jan 2016 to dec 2017 (2) patients with radiographic evidence of pulmonary tumors 2. exclusion criteria: (1) age \< 20 y/o (2) patients who can't hold their breath for 5 seconds

Keywords: chest ultrasound,lung tumor
long-term follow-up of health related quality of life in patients with acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: this study is aiming to i)measure longterm health related quality of life (hrql) outcomes of the emmace3 patients hospitalised with acute coronary syndromes (acs) and evaluate possible associations with their cardiovascular profile and to ii) linkage these data to multiple electronic healthcare records

over the last few years the chance of dying from a heart attack in england and wales has reduced dramatically. even so, there remain huge differences in mortality between hospitals. for example, up to a third of patients with a heart attack who attend hospitals in england are more likely to die than would be expected. that is, the type of treatment and the risk of death depend upon where a patient lives and which hospital they attend. in part, the variation in death may be due to the services available at the hospital or to factors such as socioeconomic deprivation. it may also relate to other factors such as depression, cardiac rehabilitation, patient experience of hospital care and health quality of life. using statistical approaches that include measures of quality of life, we propose to examine data about heart attacks in england and investigate the 'postcode lottery of care'. this research is a long term followup that promote improved patient care. in doing so, different factors affecting cardiac rehabilitation will be highlighted and healthcare policy changed so that all patients will have an equal chance of surviving a heart attack.

Eligibility criteria:
inclusion criteria: * age\>=18 years, both sexes, acute admission to hospital in england with an acs, consented to participate in emmace3 study exclusion criteria: * those in whom follow up would be inappropriate or impractical (for example patients in the terminal stages of an illness or requiring emergency treatment such that the gathering research data is not possible or appropriate.

Keywords: acute coronary syndrome health related quality of life mortality
self focus in bipolar disorder: a functional magnetic resonance imaging (fmri) study

Conditions: Bipolar Disorder; Major Depression; Rumination

Summary: the investigators propose to examine both resting state activity and functional activity during rumination and during self-processing to study the relationship between neural correlates of rumination/self-focus and self-processing in major depression and bipolar disorder.

negative rumination, a specific form of self-focus, characterized by repetitively focusing on one's symptoms of distress, and the possible causes and consequences of these symptoms, is a hallmark of depression. nearly a decade of research has culminated in evidence that the tendency to engage in negative rumination is highly correlated with depressive symptoms. rumination also plays a critical role in the etiology and maintenance of depressed states and predicts risk for mania in bipolar disorder. despite the central role of rumination in major depression and bipolar disorder, there have been few studies to date investigating the functional neuroanatomy of negative rumination, and no studies of positive rumination. the few neuroimaging studies that have utilized measures of the tendency to engage in negative rumination have focused on brain functioning when performing tasks that involve processing emotional or self-referential stimuli, but they have not studied resting state activity or functional activity during negative and positive rumination. we are examining both resting state activity and functional activity during negative and positive rumination and during self-processing to study the relationship between the neural correlates of rumination/self-focus and self-processing in major depression and bipolar disorder.

Eligibility criteria:
inclusion criteria healthy controls: * right-handed (as determined by the handedness inventory; oldfield, 1971) * normal or corrected-to normal vision and hearing exclusion criteria for healthy controls: * any current or past psychiatric history * significant medical, psychiatric or neurological illness * currently taking antidepressants, mood stabilizers, or benzodiazepines * positive mr screen (e.g., metal implant, claustrophobia, etc) inclusion criteria for patients with major depression: * current diagnosis of mdd * right-handed (as determined by the handedness inventory; oldfield, 1971) * normal or corrected-to normal vision and hearing exclusion criteria for mdd patients: * if a history of substance abuse, at least 6 months in remission * current suicidal ideation or history of suicide attempts * positive mr screen (e.g., metal implant, claustrophobia, etc) inclusion criteria for patients with bpad: * current diagnosis of bpad * right-handed (as determined by the handedness inventory; oldfield, 1971) * normal or corrected-to normal vision and hearing exclusion criteria for bpad patients: * if a history of substance abuse, at least 6 months in remission * current suicidal ideation or history of suicide attempts * positive mr screen (e.g., metal implant, claustrophobia, etc)

Keywords: bipolar disorder major depression rumination self processing