Kornimate/medical-research-clean huggingface dataset:
peritoneal microdialysis in patients undergoing low anterior resection for rectum cancer

Conditions: Cancer

Summary: anastomotic leakage is a serious complication after lar with high morbidity and mortality rates. early diagnosis and treatment is mandatory. the primary aim of the present study is to investigate the clinical use of peritoneal microdialysis and whether is able to detect anastomotic leakage prior to clinical symptoms.

patients undergoing lar for rectum cancer is subjected to peritoneal microdialyses during the postoperative period until the 7. postoperative day. samples are collected every 4-hour. samples will be analyzed continuously but the results will not be included in the clinical evaluation of the patient. before removing the microdialysis catheter a ct whit rectal enema is preformed. every day the patient will be evaluated whit a standardised clinical scoring system with attention at anastomotic leakage. a total of 150 patients will be included in this study. the results of the peritoneal microdialyses will be compared with the clinical scorings system in each patient. the results form the uncomplicated courses will be used to define the normal variations in peritoneal microdialysis. this will be compared to results from patients with various complications. the study is approved by the local scientific ethical committee no. ------

Eligibility criteria:
inclusion criteria: * histological verified cancer * the cancer must be located in rectum maximum of 15 cm. * diverting stoma is allowed * perioperative radio-chemotherapy is allowed exclusion criteria: * disseminated cancer

Keywords: anastomotic leakage after lar
effectiveness of powerball system in people with multiple sclerosis

Conditions: Neurologic Disorder; Multiple Sclerosis

Summary: there is a high percentage of impairment in the upper limbs (ul) in patients with multiple sclerosis (ms), being muscle strength and hand dexterity a determining factor for the preservation of functional activities, constituting the basis of independence and quality of life. the aim of this study is to determine the effects of a training protocol on ul muscle strength, through the nds-powerball® system, in combination with conventional physiotherapy, during 8 weeks in terms of muscle strength, coordination, fatigue, functionality and quality of life in people with ms.


Eligibility criteria:
inclusion criteria: * age between 20 and 60 years * diagnosed with ms according to mcdonald criteria with an evolution time of more than two years * evaluation in the kurtzke disability status scale in multiple sclerosis (edss) with a score between 3.5 and 6 * score less than or equal to 4 on the "pyramidal function" section of the edss functional scale * stable medical treatment for at least six months prior to surgery * muscle tone in the upper extremities no greater than 2 points on the modified ashworth scale. * muscle balance equal to or greater than 3 in the upper extremity * absence of cognitive impairment with ability to understand instructions and score equal to or greater than 4 on the minimental test. exclusion criteria: * diagnosis of another neurological disease or musculoskeletal alteration other than ms * diagnosis of any cardiovascular, respiratory or metabolic disease or other conditions that may interfere with this study * having suffered an exacerbation or hospitalization in the last three months before starting the assessment protocol, or during the therapeutic intervention process. * having received treatment with botulinum toxin in the six months prior to the start of the study * presence of visual alterations not corrected by means of ocular devices.
effects of osteopathic technique on autonomic nervous system activity

Conditions: Healthy; Dysautonomia

Summary: cranial osteopathic manipulation technique for brain and cranial nerve function, known as the fourth ventricle compression (cv4), has been recognized. rib raising (rr), aimed at reducing rib restriction and conditions associated with sympathetic hypertonia, is also employed. this study aimed to assess, in about 109 healthy individuals, the effects of osteopathic techniques (cv4 and rr) on autonomic nervous system (ans) activity, as measured by heart rate variability (hrv).

in this planned study, 109 healthy subjects will be randomly assigned to one of three groups. a total of 90-100 participants are expected to complete all stages of the study, and their data will be used in the final analysis. the first experimental group will undergo three 30-minute sessions of osteopathic therapy, including the cv4 and rr techniques. the second group will receive three 30-minute sessions of the cv4 technique alone. the placebo group will undergo a sham procedure using an ultrasound transducer. to evaluate the impact of these osteopathic techniques on autonomic nervous system (ans) function, heart rate variability (hrv) will be measured using an eeg/hrv/rsa infiniti 8 device, procomp infiniti encoder, and biograph infiniti and physiology suit software. measurements will be conducted in a seated position over a 5-minute duration.

Eligibility criteria:
inclusion criteria: * age between 20 and 60 years. * subjects not currently undergoing any form of rehabilitation, physiotherapy, or osteopathy exclusion criteria: * unstable arrhythmia in the patient's history and symptoms related to chest organs (retrosternal pain, difficulty breathing). * pregnancy. * menstruation. * smoking. * symptoms suggestive of disorders related to bowel obstruction (bloating with pain, vomiting, diarrhea). * surgical treatment in the head. * neurological diseases. * back and peripheral joint pain, trauma, and musculoskeletal dysfunction in the last 12 months. * having undergone physiotherapy or osteopathy treatment within the last month, regardless of the reason

Keywords: autonomic nervous system osteopathic medicine heart rate variability
safety of cris100 on treatment spinal cord injury

Conditions: Thoracic Spinal Cord Injury

Summary: the goal of this clinical trial is to test cris100 treatment in participants with acute thoracic spinal cord injury. the main questions it aims to answer are: * safety of cris100 * efficacy of cris100 participants will receive 75 mcg cris100 in the epicenter of the spinal injury, within 72 hours of the trauma.

participants with complete spinal cord injury between t2 and t10 (asia a, according to isncsci, 2019 revision) and: * occurred less than 72 hours ago * with surgical indication * bulbocavernous reflex present * who can receive treatment with cris100 within 72 hours after the trauma (preferably within 24 hours)

Eligibility criteria:
inclusion criteria: * signature of the free and informed consent term by the participant or legal guardian * age between 18 and 70 years old; * thoracic spinal cord injury between t2 and t10, with surgical indication, occurred less than 72 hours before surgery; * presence of bulbo cavernosum reflex; * patients with a lesion classified as asia a according to the isncsci (2019 revision); exclusion criteria: * absence of bulbocavernous reflex up to 72 hours after the trauma. * presence of severe brain trauma. * patients with lesions above t2 or below t10. * more than one site of spinal cord injury. * history of alcohol or illicit drug abuse, as defined by dsm 5 (diagnostic and statistical manual of mental disorders, 5th edition or later). * patients who need permanent mechanical respiratory support. * polytraumatized patients who, in the investigator's assessment, compromise the neurological evolution. * neurological diseases or functional dependence of any etiology prior to the trauma. * any other comorbidity that, at the discretion of the investigator, makes it impossible to include the patient in the study.
early coordinated multidisciplinary intervention to prevent sickness absence and labor market exclusion in patients with low back pain.

Conditions: Low Back Pain

Summary: in denmark the number of patients, sick listed for more than four weeks is increasing, and patients suffering from musculoskeletal disorders make one third of the total amount of long-term absenteeism. compared to other diagnoses, patients suffering from musculoskeletal diseases, including low back pain, are less likely to return to work after a period of sick leave. it seems that a multidisciplinary intervention, including cooperation between the health sector, the social sector and in the work place, has a positive effect on days off work due to musculoskeletal disorders and particularly low back pain. the aim of this study is to evaluate the effect of a work oriented multidisciplinary intervention. a randomized controlled trial will include 770 patients with low back pain. the study population consists of patients, who are sick listed or at risk of sick leave due to lbp. the control group is treated with usual care in a team with participation of a physiotherapist, a chiropractor, a rheumatologist and a local employed social worker the intervention group is treated with usual care and in addition intervention of a psychologist, an occupational physician, an ergonomist and a social worker from the local sickness benefit office. the treating physiotherapist will be the rtw-coordinator. outcome will be reported at the end of treatment as well as 6 and 12 months follow up. the primary outcome is number of days of work. secondary outcomes are disability, pain, and quality of life. this large rct study is testing the effectiveness of a preventive intervention targeting patients on short term sick leave or at risk being sick listed because of low back pain. we have developed a novel multidisciplinary team structure using the treating physiotherapist as the return to work coordinator, and having the case manager from the sickness benefit office participating in team meetings.


Eligibility criteria:
inclusion criteria: * working age adults 18-65 * low back pain (longer than 2 weeks) * sicklisted or at risk * employed or unemployed exclusion criteria: * severe comorbidity * pregnancy * difficulties in reading danish language * application for early retirement

Keywords: low back pain return to work sickness absence rehabilitation multidisciplinary intervention
to explore the effect of huaier granule on the negative conversion rate after the cea level increases again after colorectal cancer surgery

Conditions: Colorectal Cancer

Summary: this study is a prospective, observational and exploratory study to explore the effect of huaier granule on the negative conversion rate of patients with increased cea levels after colorectal cancer surgery.

this study is a prospective, single center, observational study, expected to include patients who visited the selected research center from december 2022 to december 2024 and were pathologically diagnosed with stage i-iii colorectal cancer and underwent r0 radical resection surgery. during routine clinical follow-up within one year after radical surgery, if serum cea\>5.2ng/ml occurs, patients may choose whether to use huaier granules to prevent recurrence and metastasis according to their wishes. patients who agree to use huaier granules will enter the observation group; patients who do not agree to use it will enter the control group. after the subjects are enrolled, they will be visited every 1 month ± 7 days in the first year, and every 3 months ± 14 days starting from the second year according to clinical routine diagnosis and treatment, until imaging examination determines disease progression, the end of the study, intolerable toxicity, withdrawal from the study for any reason or death, or the researcher determines no longer benefiting, whichever occurs first.

Eligibility criteria:
inclusion criteria: * age ≥18 years old, gender not limited * diagnosed with colorectal cancer through histopathology, ptnm stage i-iii * previously underwent radical resection for colorectal cancer, with a postoperative evaluation of r0 * imaging did not detect recurrence or distant metastasis * serum cea\>5.2ng/ml within 1 year after surgery (found during routine clinical follow-up) * clear consciousness, language expression or reading ability, able to communicate normally, and cooperate to complete the questionnaire evaluation * voluntary participation in this study, good compliance, and signing of informed consent form. exclusion criteria: * known to be allergic to the components of huaier granule, or to avoid or use huaier granule with caution (observation group) * cannot take medicine orally * have received anti-tumor traditional chinese patent medicines and simple preparations treatment within 1 month before enrollment (subject to the instructions) * combining medical history of other malignant tumors * diabetes with serious heart, cerebrovascular and lung diseases, severe hypertension and poor blood sugar control * suffering from intestinal diverticulitis, rectal polyps, colitis, pancreatitis, cirrhosis, hepatitis, etc * currently participating in clinical trials of other drugs * pregnant or lactating women or those planning to conceive * refusing to cooperate with follow-up visits * other reasons led the investigators to believe that it was not suitable to participate in this study

Keywords: huaier granule colorectal cancer cea level negative conversion rate
symptomatic treatment of distal tubercle fractures of the scaphoid

Conditions: Distal Tubercle Fractures of the Scaphoid

Summary: aim: the aim of this study is to assess whether patients with an acute distal tubercle fracture of the scaphoid treated with a removable brace for 4 to 6 weeks have the same level of symptoms and disability 6 months after injury as the average for the normal population. null hypothesis: patients with an acute distal tubercle fracture of the scaphoid have quick dash (disabilities of the arm shoulder and hand) scores at or above the population norm (a score of 13 in norway and 10.9 in the united states) 6 months after injury when treated symptomatically with a removable brace.

fractures of the distal scaphoid tubercle are uncommon and seem relatively benign. not a lot is known in literature about this specific type of avulsion fracture and the treatment. some surgeons recommend a cast for 4 to 6 weeks while others treat their patients with a removable brace. the only non-union reported in literature is jonssen who published a case in 1990 about a non-union of a tubercle fracture in a patient with repeated trauma. kraus et al studied 81 cases of acute scaphoid fractures and found 4 cases of tubercle avulsion fractures in this group. we suspect some patients will not seek care for this condition as it hurts for a bit and then causes no problems. response variables: * quick dash measured 6 months after injury * 11-point ordinal measure of overall pain intensity 6 months after trauma explanatory variables: * socio-demographics * age, sex, ethnicity, race, marital status, education, work status * questionnaires * quick dash after trauma (\< 2 weeks) * 11-point ordinal measure of overall pain intensity 6 months after trauma * 11-point ordinal measure of satisfaction with treatment 6 months after trauma

Eligibility criteria:
inclusion criteria: * age \> 18 years * fracture of the distal tubercle of the scaphoid on radiographs * interval between injury and diagnosis of less than 2 months * english or spanish fluency and literacy exclusion criteria: * pregnant women * inability to complete enrollment forms due to any mental status or language problems (e.g. dementia, head injury, overall illness) * patients with other fractures or injuries
effects of different surgical methods to treat obesity

Conditions: Obesity; Type 2 Diabetes; Insulin Sensitivity

Summary: obese patients have an increased risk for developing severe metabolic disorders. this risk can only partly be reduced by weight reduction. the investigators have in a pilot study investigated if removal of abdominal fat (visceral) in addition to weight loss has additional beneficial effects on the metabolic profile and weight loss. this study aims to further investigate if removal of abdominal fat (major omentum) leads to beneficial metabolic effects.


Eligibility criteria:
inclusion criteria: body mass index over 40 kg/m2 body mass index over 35 kg/m2 with obesity associated co-morbidities such as type 2 diabetes and/or additional cardiovascular risk factors - exclusion criteria: -

Keywords: obesity bariatric surgery insulin sensitivity
sitagliptin in combination with metformin and sulfonylurea

Conditions: Type 2 Diabetes Mellitus

Summary: this study will compare the effect of a new oral agent for type 2 diabetes, sitagliptin, in comparison to thiazolidinediones as the third-line oral agent, in patients with type 2 diabetes mellitus.

the aim of this protocol is to determine the non-inferiority of the effectiveness of sitagliptin compared to a control group of patients treated with thiazolidinediones as add-on therapy, in low-income ethnic minority type 2 diabetic patients who are failing to maintain adequate control with maximal doses of metformin and a sulfonylurea agent.

Eligibility criteria:
inclusion criteria: * male or female, age 18-75 * type 2 diabetes * at least 3 months of treatment with maximum tolerated doses of metformin and a sulfonylurea agent, and inadequate glycemic control (hemoglobin a1c (hba1c) \>7.0%) * able to comply with all scheduled visits and requirements of the protocol exclusion criteria: * any contraindications to the use of metformin or a sulfonylurea agent * extreme hyperglycemia or symptoms of polyuria or polydipsia * current or previous chronic use of insulin (other than for treatment of gestational diabetes) * history of confirmed (or clinical suspicion of) type 1 diabetes mellitus * episodes of symptomatic hypoglycemia averaging greater than once per day * estimated glomerular filtration rate (egfr) \< 60 ml/min * subjects with active hemolytic anemias or hemoglobin variants that render the measurement of hba1c unreliable * history of any clinically significant hepatic, cardiovascular (including the use of digoxin), or other major systemic disease that may make the use of sitagliptin unsafe, or otherwise make the interpretation of the data difficult. * female subjects of childbearing potential who are sexually active and not using a reliable form of contraception * current pregnancy or lactation. * subjects who will likely require or initiate therapy with drugs that may interfere with glucose metabolism during the course of the study. * subjects who are in another investigational study or have received another investigational medication within 30 days of study entry * subjects who are unable or unwilling to give informed consent, comply with all components of the study protocol, attend all scheduled follow-up visits, or present other barriers that would make the implementation of the protocol unusually difficult.

Keywords: sitagliptin type 2 diabetes combination therapy
to study the safety and clinical outcomes of the absorb bioresorbable vascular scaffold (bvs) system in patients with de novo lesions in previously untreated vessels

Conditions: Coronary Disease; Coronary Artery Disease; Coronary Restenosis

Summary: the purpose of this study is to determine the safety and clinical outcomes of the absorb bvs for daily use in patients with de novo lesions in previously untreated vessels.

absorb uk registry is a prospective, single arm, post-market registry designed to: * provide ongoing post-market surveillance for documentation of safety and clinical outcomes of the absorb everolimus eluting bvs system in daily percutaneous coronary intervention (pci) practice per instructions for use (ifu, on-label use). * collect additional information (e.g. acute success) to evaluate handling and implantation of absorb bvs by physicians under a wide range of commercial use conditions and following routine clinical practice.

Eligibility criteria:
inclusion criteria: the inclusion criteria must follow the most recent ifu which may include but are not limited to the following: * patient must be at least 18 years of age at the time of signing the informed consent form * patient is to be treated for de novo lesions located in previously untreated vessels. * patient must agree to undergo all required follow-up visits and data collection. exclusion criteria: the exclusion criteria must follow the most recent ifu which may include but are not limited to the following: * inability to obtain a signed informed consent from potential patient. * patient belongs to a vulnerable population (per investigator's judgment, this also includes people with a direct link (hierarchical or financial benefit) to the registry doctor or the registry sponsor).

Keywords: bioabsorbable coronary stent everolimus drug eluting stents stents angioplasty coronary artery disease total coronary occlusion coronary artery restenosis stent thrombosis vascular disease myocardial ischemia coronary artery stenosis cad caod
lung ultrasonography in covid-19 pneumonia

Conditions: Lung Ultrasound; Pneumonia; Covid19

Summary: lung ultrasonography has been used for diagnosis and treatment in many departments including intensive care before the pandemic. the gold standard method for the diagnosis of pneumonia is still chest tomography. ultrasonography, which has advantages over tomography, has also been tried to be used in covid 19 pneumonia.

in this study, it was aimed to investigate the efficiency of lung ultrasonography in diagnosis of covid 19 pneumonia.

Eligibility criteria:
inclusion criteria: * 18 and 85 years old * hospitalized in intensive care unit * pcr tested * thoracic ct applied exclusion criteria: * previous lung and thoracic wall surgery * anatomically with thoracic wall disorder * patients who did not consent to participate in the study
mechanism and early intervention research on ali during emergence surgery of acute stanford a aortic dissection

Conditions: Acute Aortic Dissection

Summary: the morbidity rate of stanford a type acute aortic dissection（aad） has been increasing, about 5-10/100,000\* per year. emergency surgery has been the main treatment for acute aortic dissection, however perioperative mortality rate can be as high as 15\~30%. acute lung injury (ali) is one of the main complications that happen during the perioperative period, which by itself covers 30%-50% of the overall mortality rate. both domestic and foreign countries lack researches on risk factors, pathogenesis, disease progression and outcome of ali, which happen during the perioperative period of acute aortic dissection patients. this topic study follow projects in the preoperative of acute aortic dissection'surgery 1. hemodynamic changes (aortic dissection resulting in acute aortic regurgitation, cardiac tamponade and proximal high blood pressure) 2. ischemia - reperfusion injury of aortic dissection distal organ 3. aortic intima-media exposure cause coagulation / fibrinolytic system function disorder 4. systemic inflammatory response syndrome; use relevant clinical radiographic parameters, indicators of respiratory mechanics (oxygenation index and lung injury index) and biochemical indicators. to discuss risk factors and possible mechanisms of add patients with pre-operative ali and observe their influences on the progress and prognosis of aad, to explore early intervention in the preoperative for possible risk factors and mechanisms and to evaluate their influences on the prognosis, to achieve the purpose of reducing aad perioperative mortality of ali and medical expenses.


Eligibility criteria:
inclusion criteria: * aad patients within 48 hrs of onset who are prepared for aortic surgery * age between 18 and 70 * willing to sign the informed consent exclusion criteria: * a history of chronic respiratory disease before onset * a history of chronic heart failure or coronary heart disease before onset * a history of chronic liver or kidney dysfunction before onset * severe central nervous system syndrome after admission * refuse to sign the informed consent

Keywords: aortic dissection acute lung injury injury mechanism early intervention