Kornimate/medical-research-clean huggingface dataset:
gmk-uni anatomical uka: fixation of cemented vs cementless designs

Conditions: Osteoarthritis, Knee

Summary: unicompartmental knee arthroplasty (uka) is the principal surgical alternative to the total knee arthroplasty (tka) in patients with end-stage unicompartmental tibiofemoral osteoarthritis (oa) of the knee. the current comparative randomized study aims to evaluate the fixation of cemented and cementless designs of gmk-uni unicompartmental knee prosthesis over a 5-year time period.

the primary objective is to compare the quality of fixation of cemented and cementless designs of gmk-uni unicompartmental knee replacement at 2 years of follow-up. the secondary objectives include the evaluation of the patient improvement (subjective and objective) using the new knee society score (kss); the patient's anterior pain following uka and any eventual patella-femoral disorder; implant survival rate using the kaplan meier analysis; post-op radiological findings and adverse events. the primary outcome aims to compare the occurrence of radiolucency's lines (both partial and complete) between the two study groups. secondary outcomes include new kss, oks, kaplan meier analysis and stability and fixation of uni prosthesis. all patients who meet the inclusion criteria to take part in the current clinical study will be invited to participate before the surgery. subjects will be randomized during the screening; half of them will receive the cemented gmk-uni anatomical uka and the other half the cementless gmk-uni anatomical uka. clinical data will be recorded on crf at those time-points: * before the surgery * during the surgery * after the surgery at 3 months, 1, 2, 3 and 5 years.

Eligibility criteria:
inclusion criteria: * patients with end-stage unicompartmental tibiofemoral osteoarthritis (oa) of the knee that meet the indications for use according to medacta implants included in this study (on-label use); * those suffering from unilateral osteoarthritis or osteonecrosis of the medial compartment; * frontal deformity \< 10° (evaluated on weight-bearing long-axis x-rays); * flexion contracture \< 10°; * intact ligaments; * patients who are willing and able to provide written informed consent for participation in the study. written informed consent must be obtained prior to the patient's surgery; * patient's age over 18 years old; * patient with bmi \< 40 kg/m2; * patients must be willing to comply with the pre and post-operative evaluation schedule. exclusion criteria: * patients with one or more medical conditions identified as a contraindication defined by the labelling on any medacta implants used in this study; * any patient who cannot or will not provide informed consent for participation in the study; * patients who need to undergo lateral unicompartmental knee arthroplasty; * patients who need a revision surgery; * patients who need a patella-femoral joint prosthesis; * patients who had previously undergone high tibial osteotomy or acl reconstruction; * patients with bmi ≥ 40 kg/m2; * patients unable to understand and take action; * any case not described in the inclusion criteria; * patients aged under 18 years;
effects of furosemide plus small hss in subjects with heart failure with reduced ejection fraction (hfref)

Conditions: Heart Failure，Congestive

Summary: the investigators sought to evaluate the effectiveness of treatment with furosemide + hss in terms of reduction of serum levels of some chosen markers of heart failure and the response in terms of these markers at a compensated state after an acute saline load.

all consecutive patients aged \>18 years with a diagnosis of acute heart failure or exacerbation in chronic heart failure due to heart failure with reduced ejection fraction ( hfref) admitted to the ward of internal medicine were enrolled from march 2017 to june 2019. enrolled subjects were treated with treatment with hypertonic saline solutions + furosemide e.v and control subjects with congestive heart failure randomized to treatment with intravenous furosemide only. chronic kidney disease patients undergoing dialysis replacement, acute coronary syndrome, myocarditis, pneumonia, myopathies, neoplasms have been excluded. patients underwent at t0 (at 24 hours from admission), t1 (after 6-8 days after treatment with high dose furosemide+ hss ), t2 (after a saline load) venepuncture to obtain venous blood samples for the determination of serum concentrations of n terminal pro b-type natriuretic peptide, high-sensitive cardiac troponin t, galectin 3, il-6.

Eligibility criteria:
inclusion criteria: * congestive heart failure exclusion criteria: * acute myocarditis * active pulmonary or liver diseases * autoimmune disorders * infections * malignant diseases * muscle disorders * renal insufficiency * chronic inflammatory diseases * rheumatological diseases * haematological diseases * chronic treatment with anti-inflammatory drugs

Keywords: congestive heart failure hfref biomarkers inflammation atrial stretching furosemide
a novel device for neck pain in active-duty military personnel with forward head posture.

Conditions: Neck Pain

Summary: neck pain is a common complaint among active duty military personnel, and can have tremendous impacts on quality of life and participation in duty-related activities. treatments for spinal pain in military personnel are typically multimodal, relying upon physical therapy, pharmacological agents, spinal manipulation, and psychotherapy. however, there does not exist a wide body of evidence to support many of these treatments in active-duty military. the cervigard neck collar was designed to treat posture-related neck pain with minimal effort and time required for treatment by the patient. however, this has yet to be tested experimentally. the objective of this study is to evaluate the treatment effect and safety of a novel device for the treatment of neck pain using self-reported pain and function measures, as well as objective radiological measures of cervical lordosis and head posture. participants will be randomized to be fitted with and receive the cervigard neck collar either immediately, or 6-weeks after being screened. participants will complete neck pain and function questionnaires, and have cervical x-rays collected at screening, treatment, 6 weeks, and 12 weeks (for the immediate group). participants will be instructed to wear the collar every day for the duration of the trial. self-reported neck pain and function measures will be collected, as well as cervical x-rays, protocol adherence measures, and adverse events. the intervention is expected to reduce neck pain/discomfort, improve function, and improve cervical lordosis.


Eligibility criteria:
inclusion criteria: * deers eligible * age 18 and 45 year old (inclusive) * neck pain duration ≥ 3 months without neurological signs and have been seen by a provider. * conventional treatments have not decreased neck pain * neck pain ≥ 4 on a 0-10 point numerical rating scale (0 = "no pain", 10 = "maximum pain") * forward head posture, indicated by forward placement of the head relative to the shoulders. exclusion criteria: * history of a tumor in the cervical spine and/or head/neck region within the past 6 months. * infection involving the cervical spine and/or head/neck region within the past 6 months. * generalized medical disorders that would weaken the vertebrae or other tissue structures within the cervical spine region. * fracture that is acute and/or still healing * spinal deformities (e.g. fixed kyphosis, ankylosing spondylosis) * medical and/or psychological condition that would preclude safe participation
a single ascending dose study of bms-791325 in hcv infected subjects

Conditions: Chronic Hepatitis C

Summary: the primary purpose of this study is to evaluate the safety profile and tolerability of single oral doses of bms-791325 in subjects with chronic hepatitis c infection


Eligibility criteria:
inclusion criteria: * chronically infected with hcv genotype 1 * treatment naive or treatment non-responders or treatment intolerant * hcv rna viral load of ≥10\*5\* iu/ml * bmi 18 to 35 kg/m² exclusion criteria: * any significant acute or chronic medical illness which is not stable or is not controlled with medication and not consistent with hcv infection * major surgery within 4 weeks of study drug administration and any gastrointestinal surgery that could impact the absorption of study drug * co-infection with hiv or hbv
verifying remote monitoring effect on net cardiovascular outcome; remoteverify (rêve)

Conditions: Congestive Heart Failure; Defibrillators; Cardiac Resynchronization Therapy

Summary: this study investigates the impact and safety of wireless monitoring on the prognosis of heart failure patients with implanted pacemakers and defibrillators. it aims to examine the frequency of unplanned early hospital visits and the early diagnosis/intervention of disease exacerbation based on the presence or absence of wireless monitoring. additionally, the study analyzes the influence of wireless monitoring on the patient's disease progression as well as satisfaction of the study participants.


Eligibility criteria:
inclusion criteria: * consented heart failure patients (lvef\ 20 years * patients who are new to remote monitoring exclusion criteria: * for patients with a life expectancy of less than 6 months. if patient do not understand the contents of wireless monitoring or it is difficult to fill out the consent form due to cognitive decline. if wireless monitoring is performed with a patient enrolled in another clinical trial which remote monitoring may affect the previous enrolled study.

Keywords: remote monitoring congestive heart failure defibrillators cardiac resynchronization therapy
generation of a cellular model of cadasil from skin fibroblasts

Conditions: CADASIL

Summary: cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (cadasil) is an archetypal small vessel disease of the brain caused by dominant mutations in the notch3 receptor. cardinal vascular lesions include deposition of granular osmiophilic material (gom) within the basal lamina of smooth muscle cells, progressive smooth muscle cell loss, and fibrosis of the media. pathogenic mutations alter the number of cysteine residues in the extracellular domain of notch3 (notch3 ecd), leading to its abnormal accumulation in the gom deposits. vascular smooth muscle cell has been identified as the primary target cell in this disease. pathophysiological processes leading from notch3 mutations to smooth muscle cell loss remain poorly understood. the investigators propose to study these mechanisms by reprogramming skin cells to become stem cells and then differentiating them to vascular smooth muscle cells. the hypothesis of this study is that the differentiated smooth muscle cells will display the characteristic features of cadasil, ie, notch3 ecd accumulation and gom deposits.


Eligibility criteria:
inclusion criteria : * between 30 and 60 years; * having a social security scheme or, cmu ; * diagnosis of cadasil confirmed by molecular analysis performed previously (missense mutation in the notch3 gene affecting the number of cysteine in one of the 34 egfr of notch3 ) ; * no countra-indication for a skin biopsy (ongoing treatment with anti-coagulant, history of bleeding disorder or deficiency of blood clotting factors) ; * written consent given. exclusion criteria : * patients without social security scheme or, cmu ; * patients aged under 30 or over 60 years at the time of the first visit ; * pregnant women beyond the 5th month of pregnancy * patients who are not able to give informed consent ; * countra-indication to the achievement of the skin biopsy ( ongoing treatment with anti- coagulant, history of bleeding disorder or deficiency of coagulation factors ) .
the effect of local anesthesia on postoperative pain in vaginal hysterectomy

Conditions: Pain, Postoperative

Summary: the investigators aim is to study the effect of pre-operative local anesthetic on post vaginal hysterectomy pain.

this is a double-blinded, randomized, controlled trial. women who undergone elective vaginal hysterectomy and gave their informed consent were included. exclusion criteria included additional abdominal, chronic pelvic pain, malignancy, and allergy to bupivacaine. solutions of either bupivacaine-hydrochloride 0.5%, or sodium-chloride 0.9% as a placebo, were prepared prior to surgery, according to randomization. the chosen solution was injected before incision, as a modified paracervical block, and in each resection line (sacro-uterine and cardinal ligaments). the amount of fluid administered was 10 ml. when colporrhaphy was also performed, an additional 5 ml of solution were injected in the midline of the vaginal wall prior to each incision line. by utilizing the 10 cm visual-analogue-scale (vas) we examined the differences in post-operative pain at rest at 3, 8, and 24 hours, and during ambulation at 8 and 24 hours using multivariate linear regression models. we also assessed the differences in analgesics given at the different time points between the groups using multivariate negative binomial regression models.

Eligibility criteria:
inclusion criteria: * elective vaginal hysterectomy on benign indication exclusion criteria: additional abdominal, chronic pelvic pain, malignancy, and allergy to bupivacaine.
the efficacy and acceptability of an internet-based self-help program to reduce burnout

Conditions: Burnout, Professional

Summary: the goal of this clinical trial is to determine whether an internet-based self-help program reduces burnout in teachers. the study will also evaluate the program's acceptability which means assessing the extent to which users complete the program and find it useful. the main questions it aims to answer are: * does the program reduce the level of burnout in teachers? * does the program contribute to an increased sense of meaning for teachers? * how much of the program do teachers finish?

this concurrent multiple-baseline single-case experimental study aims to assess the efficacy and acceptability of an internet-based self-help program designed to mitigate burnout among teachers. the self-help program, named mylife, adopts an acceptance and commitment therapy framework and comprises eight modules. preceding the commencement of the study, the program was tailored to address the specific needs of teachers through collaboration with people with lived experiences and the administration of nationwide surveys. additionally, the daily questions utilized in this single-case study design were meticulously crafted for this study. in this study no guidance other than reminders will be offered. participants will be instructed to: * engage with program content, including audio and text components, every three days over a four-week period. * respond to daily questions once in day for eight weeks and both before and after the study, utilizing scales and questionnaires. the research questions are as follows: 1. to what extent does the program alleviate burnout among teachers? 2. does the program foster a heightened sense of meaning in teachers' professional lives? 3. what is the completion rate of the program among participating teachers? 4. does the program effectively diminish experiential avoidance? hypotheses: 1. teachers participating in the mylife program will experience a significant decrease in burnout levels compared to baseline measures. 2. the mylife program will lead to a significant increase in the perception of meaning in teachers' professional lives. 3. mylife program will have a good acceptability. 4. participation in the mylife program will be associated with a significant reduction in experiential avoidance among teachers.

Eligibility criteria:
inclusion criteria: * being a teacher in türkiye * having burnout symptoms related to the workplace. * able to use e-mail, internet and mobile phone * able to read fluently in turkish exclusion criteria: * currently prescribed psychotropic medication or any change in psychotropic medication in last two months * currently undergoing psychotherapy. * having thoughts of suicide or self-mutilation.

Keywords: burnout acceptance and commitment therapy i̇nternet-based psychotherapy single-case design
mesh repair of anterior vaginal wall prolapse

Conditions: Anterior Vaginal Wall Prolapse

Summary: the purpose of this study is to determine whether reenforcement with polypropylen mesh compared with traditional anterior colporrhaphy for anterior vaginal wall prolapse results in fewer recurrences.

anterior vaginal wall prolapse is the most common type of pelvic organ prolapse in postmenopausal women. this anatomic defect has traditionally been repaired with anterior colporrhaphy plication, a series of interrupted stitches being the main surgical component. the procedure is associated with a high recurrence rate, up to 32 % even after using paravaginal repair along with anterior colporrhaphy.it has been sought to resolve the problem of recurrence using artificial mesh as in the repair of abdominal hernias. comparison: anterior vaginal wall repair with or without reinforcement with polypropylene mesh were compared in a prospective randomized study

Eligibility criteria:
inclusion criteria: * postmenopausal women with symptomatic anterior vaginal wall prolapse to the hymen or beyond when under strain and referred for reconstructive pelvic surgery exclusion criteria: * an apical defect indicating concomitant vaginal fixation, or stress urinary incontinence necessitating surgery, or her main symptomatic prolapse component was in the posterior vaginal wall.

Keywords: cystocele surgery mesh genital prolapse
markers of neurological damage post covid-19 in plwh

Conditions: COVID-19; Hiv

Summary: both hiv infection and covid-19 are associated to cognitive and psychiatric impairment, like anxiety and depression. these disturbs are well-known in hiv infection and partially characterized in covid-19.

hiv has an high neurotropism and the hiv-associated dementia was one of the most frequent clinical complications and principal cause of death before the introduction of antiretroviral theraphy (art). however, also in plwh taking art and with suppressed viral load over years, the proportion of neuro-cognitive impairment, anxiety and depression remain higher then the general population. these problems may be the consequence of a persistent systemic and central nervous system (cns) immuno-activation caused by the persistence of viral reservoir in the peripheric and tissutal lymphocytes. neurological and psychiatric problems have been described in a variable proportion in patients with corona virus disease 19 (covid-19) and in the complex it doesn't seems to be the direct consequence of cns cellular infection, but rather of inflammation and coagulations disorder due to covid-19 in the nervous tissue.

Eligibility criteria:
inclusion criteria: * hiv+ covid+: people living with hiv that get corona virus disease 19 (covid19) diagnosed at least 9 month ago with a positive rino-pharyngeal swab (molecular or antigenic), or with compatible clinic and a positive serologic test for sars-cov2 before the vaccination; age \> 50 years old, no gender. * hiv+ covid-: people living with hiv that had not get covid19. age\>50 years; no gender. * hiv- covid+: people without hiv that get covid19 diagnosed at least 9 month ago with a positive rino-pharyngeal swab (molecular or antigenic), or with compatible clinic and a positive serologic test for sars-cov2 before the vaccination; age \> 50 years old, no gender. * hiv- covid-: people without hiv that had not get covid19 (healthy people and volunteers) age\>50 years; no gender. exclusion criteria: * inability to perform the neuro-cognitive or functional tests due to neurologic deficit (inability to writing, reading, understand how to perform the tests)
ohio state university multiple myeloma and amyloidosis data registry and sample resource

Conditions: Plasma Cell Dyscrasias; Monoclonal Gammopathy of Undetermined Significance; AL Amyloidosis; Multiple Myeloma

Summary: the investigators are researching patients with diseases of their plasma cells in order to improve their quality and length of life. the investigators have created a database of patient information, blood samples, and bone marrow tissue in order to achieve the following three goals: * surveillance: the investigators want to track what treatments patients get or don't get, how effective they are, how they feel, what complications they suffer, how long they stay in remission, and how long they live. * contact: because myeloma and amyloidosis are rare, less than 700 patients are diagnosed in the state of ohio each year, patients often feel they don't have accurate information. the investigators want to provide them access to our clinical team (both phone and email consultations, even office visits for patients that can come to columbus) as well as information regarding informational events pertaining to your disease and local support groups. * research: because nearly all myeloma and amyloid patients relapse and treatment is eventually unsuccessful, our focus is to develop more effective treatments that not only prolong life, but cure the disease. periodically the investigators will inform them about clinical trials studying new drugs or treatment paradigms.

the investigators propose to contact and interact with all patients with plasma cell dyscrasias in the state of ohio (and all patients diagnosed or treated at ohio state medical center) for both surveillance and research purposes in order to develop interventions targeted to decrease their morbidity and mortality.

Eligibility criteria:
inclusion: diagnosis of a plasma cell dyscrasia exclusion: prisoners are excluded from participation as they have no standard access to the ohio state myeloma clinic and would impede the research objective of this protocol.

Keywords: mgus multiple myeloma tissue bank
mindfulness training along strength training among sprinters with patellofemoral pain

Conditions: Patellofemoral Pain

Summary: the study is to find out of the comparative sprinting-induced patellofemoral pain syndrome (pfps) causes physical and psychologicalal distress in athletes. while strength training has been used for physical rehabilitation, mindfulness training is a recent addition to rehabilitation science with the potential to improve both physical and psychological protocols.

research on the effects of mindfulness and strength training on knee function in sprinters with patellofemoral pain is lacking, despite a wealth of studies on the psychological rehabilitation of athletes. the study's findings indicated that stress reduction and pain management enhance knee function. to improve the physical and psychological elements of sprinters with patellofemoral discomfort, this research assists them integrate mindfulness training with strength training. strength training to improve knee stability and muscle balance, as well as mindfulness to lessen the psychological effects of pain and stress, can help sprinters with both the mental and physical aspects of patellofemoral pain. research was being done on this combined approach in this specific population.

Eligibility criteria:
inclusion criteria: * age group between 18 to 25 years. * female runners. * pfp conformation check (single leg squat, and eccentric step) (24) exclusion criteria: * post-surgical condition from the past 6 months * chronic medical condition (cancer, copd) * players addicted to any drugs or alcohol

Keywords: pfps agility strength training strength training mindfulness training