Kornimate/medical-research-clean huggingface dataset:
portal vein flow variability to quantify right-sided hemodynamic congestion (portal)

Conditions: Congestion; Heart Failure; Right Heart Catheterisation; Central Venous Pressure; Doppler Echocardiography

Summary: this study evaluates the accuracy of a comprehensive venous doppler echography including the portal vein pulsatility index (pvpi) to quantify invasively measured right-sided venous pressures. a substudy will correlate invasive and non-invasive hemodynamic measurements to ballistocardiography and seismocardiography with the kino-cardiograph (kino) device (heartkinetics, waterloo, belgium).


Eligibility criteria:
inclusion criteria: * at least 18 year old and able to provide informed consent; * consecutive patients scheduled for right heart catheterisation by a dedicated heart failure specialist at the centre of cardiovascular diseases (university hospital brussels, jette, belgium). exclusion criteria: * major anatomical variations of the portal veins (agenesis of left and right portal vein) and/or arterio-portal vein fistula; * patients with child-pugh b or c liver cirrhosis or liver transplant; * body mass index \< 20 kg/m².

Keywords: congestion doppler echocardiography central venous pressure right heart catheterisation heart failure
uroccr database: french research network for kidney cancer

Conditions: Kidney Cancer

Summary: within the framework for kidney cancer care, with the recent diversification of treatment modalities of these tumors and the deployment of the concept of multidisciplinary team, it was considered necessary to adapt the research tools to reality of health-care for patients with kidney cancer. uroccr is the french research network for kidney cancer, funded by the french national cancer institute as part of the call for projects for clinical and biological databases (bcb). depending on the case presentation and disease evolution, more than a thousand of different variables can be recorded. at the same time, biological samples (plasma, urine, healthy and tumor tissues) are collected. this database contains a considerable number of information and high added value since it is the result of multiple expertises that make it not only a multidisciplinary tool but also multicenter, allowing fundamental, translational and clinical research.

the uroccr database is a national medico-scientific network focused on therapeutic management and applied research in kidney cancer. secondary objectives: 1. - evaluate and compare different surgical approaches in the treatment of kidney cancer, 2. - evaluate and compare safety/efficacy of different drugs in the treatment of kidney cancer.

Eligibility criteria:
inclusion criteria: * adult patient with kidney cancer * patient with no opposition to collection of its data for the study exclusion criteria: none

Keywords: kidney cancer surgical approaches medical treatment multicentric and multidisciplinary network
study of genes and the environment in patients with ovarian cancer in the east anglia, oxford, trent, or west midlands regions of the united kingdom

Conditions: Ovarian Cancer

Summary: rationale: studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. purpose: this study is looking at genetic susceptibility for cancer and interactions between genes and the environment in patients with ovarian cancer.

objectives: * to obtain epidemiological information and biological material on a population-based series of ovarian cases. * to define the proportion of ovarian cancer incidence attributable to mutations in known predisposing genes (e.g., brca1 and brca2). * to determine the risk associated with predisposing mutations by examining the cancer risks in relatives of patients who are shown to be carriers. * to examine the effect of nongenetic risk factors in mutation carriers. * to determine the pathological and clinical characteristics of ovarian cancers occurring in brca1/2 mutation carriers as compared with that in noncarriers. * to establish whether mutations at other loci may predispose to ovarian cancer by comparing the frequency of alterations in ovarian cancer patients with that in cancer-free controls identified through the european prospective investigation of cancer (epic) study. outline: this is a multicenter study. patients complete an epidemiological questionnaire. the questionnaire will request identifying information on the patient's first-degree relatives. blood samples are collected from patients. dna is extracted from these blood samples and from samples collected from cancer-free control participants in mrec-search-control as well as from additional controls through the european prospective investigation of cancer (epic) study (a population based study of diet and health based in norfolk, east anglia). dna samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes. in addition to the ovarian cancer patients recruited for this study, patients with breast, endometrial, prostate, colorectal, bladder, kidney, pancreatic, brain and esophageal cancer, malignant melanoma, and lymphoma cancer are recruited in the following related clinical trials: mrec-search-breast, mrec-search-endometrial, mrec-search-prostate, mrec-search-colorectal, and mrec-search-cancer.

Eligibility criteria:
disease characteristics: * diagnosis of ovarian cancer within the past 5 years * identified through the east anglia, stoke and west midlands cancer registries serving any of the following geographic regions of the united kingdom: * east anglia * oxford * trent * west midlands patient characteristics: * identified by the patient's general practitioner as fit to contact for this study * no serious mental illness or retardation prior concurrent therapy: * not specified

Keywords: ovarian epithelial cancer ovarian germ cell tumor ovarian sarcoma ovarian stromal cancer
the effect of psychoeducation based on acceptance and commitment therapy applied to patients diagnosed with generalized anxiety disorder on cognitive avoidance levels and coping attitudes

Conditions: Generalized Anxiety Disorder

Summary: this study will be conducted to determine the effects of acceptance and commitment therapy-based psychoeducation on cognitive avoidance levels and coping attitudes in patients diagnosed with generalized anxiety disorder. h0: acceptance and commitment therapy-based psychoeducation has no effect on the cognitive avoidance levels and coping attitudes of patients diagnosed with generalized anxiety disorder. h1: acceptance and commitment therapy-based psychoeducation reduces the cognitive avoidance levels of patients diagnosed with generalized anxiety disorder. h2: acceptance and commitment therapy-based psychoeducation affects the coping attitudes of patients diagnosed with generalized anxiety disorder.


Eligibility criteria:
inclusion criteria: * having been diagnosed with generalized anxiety disorder according to dsm-5 diagnostic criteria and receiving outpatient treatment * being literate * having no problems understanding or speaking turkish * being in the 18-65 age group * having not received such training in the last 6 months exclusion criteria: * those diagnosed with another comorbid mental illness patients with a mental condition that makes cooperation impossible, such as intellectual disability or memory impairment * the illiterate * patients who do not consent to be interviewed

Keywords: generalized anxiety disorder acceptance and commitment therapy cognitive avoidance coping attitudes
hfip ex-vivo study

Conditions: Sepsis

Summary: sepsis, a multi organ failure caused by infectious diseases, is a major health burden with an average mortality rate of 26%. cells of the innate immune system of hosts recognize specific patterns of pathogenic bacteria and trigger an inflammatory response. in case of sepsis, this inflammatory response takes a deregulated course, expressing an overwhelming amount of pro-inflammatory cytokines leading to a loosening of endothelial tight junctions, evasion of intravasal fluids and proteins into the interstitium, as well as direct tissue damage throughout an overproduction of reactive oxygen species by neutrophils. these pathological changes of the host's proper immune system lead to a multi organ failure, which characterize a clinical pathomechanism of sepsis. several studies confirmed an immunomodulatory effect of sevoflurane's primary metabolite hexafluoroisopropanol (hfip) attenuating pro-inflammatory cytokine expression with a consecutive improvement of organ function and survival in rodent models of sepsis. until now, there are no data available confirming this effect in septic patients as well. with this study, the direct impact of sevoflurane's primary metabolite hfip on cytokine expression in the blood of septic patients will be investigated for the first time.


Eligibility criteria:
inclusion criteria: * patients admitted to the emergency ward with suspicion of infection and a qsofa score ≥ 2 points (respiratory frequency \> 22/minute, systolic blood pressure \< 100 mmhg, glasgow coma scale \< 15). * male and female subjects with at least 18 years of age. * written informed consent by the participant after information about the project. in emergency cases where a written consent cannot be obtained immediately, due to the patient's medical conditions, the existence of a patient decree and of a representative in the emergency situation is evaluated according to the swiss civil code. informed consent will be obtained from the representative. a medical doctor, furthermore, not participating in the investigation, guarantees the medical care of the patient by the defending of his/her interests. after recovery, the patient will be informed as soon as possible about the trial and consent is requested. exclusion criteria: * acquired immune deficiency syndrome * anti-il-6 therapy (e.g. kevzara®) within the last 60 days * application of a cytokine absorber * pregnancy and/or breast feeding
cardiovascular events in chronic obstructive pulmonary disease patients initiating olodaterol or other long-acting beta2 agonists

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: examine the risk of cardiovascular events (cardiac arrhythmia or myocardial ischemia) or all-cause mortality in chronic obstructive pulmonary disease (copd) patients who are new users of olodaterol or other labas available for the treatment of copd.

purpose: time perspective:

Eligibility criteria:
inclusion criteria: * copd diagnosis * aged 40 years or older (to minimise the likelihood of including individuals who have asthma only) * new user of olodaterol or a new user of indacaterol, salmeterol, or formoterol (not in fixed-dose combination with an inhaled corticosteroid) and have no dispensing of any laba in the 6 months before the index date * at least 1 year of enrolment in the electronic database before their first laba dispensing (defined as the index laba) * complete data on sex exclusion criteria: none
conscious sedation with suprainguinal facia iliaca block versus ilioinguinal iliohypogastric block for tavi

Conditions: Aortic Stenosis

Summary: the aim of the present study is to compare suprainguinal fascia iliaca block and ilioinguinal-iliohypogastric (ii-ih) nerve block in improving the quality of conscious sedation, including reducing patients' requirements for analgesia also better satisfaction for both patient and surgeon as regards patient outcome and decreasing the incidence of conversion to general anesthesia during tavi procedure


Eligibility criteria:
inclusion criteria: * aged \>20 years with severe aortic stenosis undergoing elective, non-emergent, non-urgent transfemoral sapien 3tm (edwards lifesciences corp., irvine, ca, usa) or corevalvetm (medtronic, minneapolis, mn, usa) implantation were included in the study exclusion criteria: * younger than 20 years
effects of massage between sets of an intense isokinetic exercise- protocol of knee extensors in tae kwon do athletes

Conditions: Athletic Performance

Summary: 26 tae kwon do athletes performed a vigorous exercise program on the isokinetic dynamometer twice in a period of 10 days, each time on a different extremity. in this way two groups of 26 individuals each were created, with the same individuals alternating. in the massage group (mg) a sport massage was applied between the sets while in the control group (nmg) the break was passive.

objective: τo investigate the effects of massage in athletic performance when applied during intervals of an intense isokinetic exercise protocol for knee extensor muscles. design: randomized controlled trial. participants: 26 tae kwon do athletes performed a vigorous exercise program on the isokinetic dynamometer twice in a period of 10 days, each time on a different extremity. in this way two groups of 26 individuals each were created, with the same individuals alternating. in the massage group (mg) a sport massage was applied between the sets while in the control group (cg) the break was passive. main outcome measures: knee flexion and extension rom, thigh circumference, and creatine kinase (ck) levels in blood plasma were measured before and after each test while l-doms was measured 24, 48, 72 and 96 hours after the exercise.

Eligibility criteria:
inclusion criteria: * professional athletes * age range between 18-25. exclusion criteria: * conduction of any strengthening exercises on the day before the tests * musculoskeletal injury during the last six months * background of knee trauma and/or surgery

Keywords: sport massage delayed onset muscle soreness muscles recovery continuous concentric eccentric exercise
health care use and costs of functional somatic disorders

Conditions: Bodily Distress Syndrome; Irritable Bowel; Fibromyalgia; Chronic Widespread Pain; Chronic Fatigue Syndrome

Summary: the goal of this observational case-control study is to learn about direct healthcare use and costs of functional somatic disorders. the aim of the proposed study is to investigate the use and costs of direct healthcare for individuals with functional somatic disorders. researchers will compare direct healthcare use and costs of individuals with functional somatic disorders and compare them with that of healthy controls and individuals with other severe physical disease, respectively.

functional somatic disorders (fsd) are common conditions characterized by persistent patterns of physical symptoms that cannot be better explained by other physical or mental conditions. the conditions may cause severe impairment for the patients who are often characterized by impaired physical and mental health, lower social status, and poor labour market association. in 2005, it was estimated that fsd accounted for 3% of hospitalizations and 10-20% of health care expenses in denmark, and a newer danish primary care study has shown patients with fsd to have higher annual health care costs compared with conventionally-defined conditions. in foreign nations, studies in clinical samples have shown increased direct and indirect health care costs of fsd which showed a dose-response relationship with severity of the fsd. one canadian population-based study found increased health care use and costs in children, adolescents, and young adults with a first health record diagnosis of somatic symptom and related disorders. even though these previous studies provide valuable knowledge to the field of fsd, their methodology may give rise to bias, i.e. inclusion of highly selected patient samples, the use of various diagnostic criteria for defining fsd, and the establishment of fsd by means of self-report. evidently, studies investigating the socioeconomic burden in terms of direct health care use and costs of fsd in a randomly obtained population-based sample using solid methodology such as validated symptom criteria and diagnostic interviews for establishing fsd are highly lacking. the objectives of this proposed study are: to describe and investigate the healthcare use and healthcare costs for individuals with fsd and compare them with 1. individuals without fsd, and 2. individuals with severe physical disease

Eligibility criteria:
inclusion criteria: * none exclusion criteria: * not born in denmark * not being a danish citizen * pregnancy.
breast cancer resiliency through exercise program (b-rep)

Conditions: Breast Cancer Female

Summary: the study will use a cross-sectional study design with a follow-up 2-arm randomized controlled trial with that has assessments at baseline, post-intervention (i.e., week 12), and 3-months post-intervention (i.e., week 24). the 2 arms are the 12-week intervention and a health education control among 60 black breast cancer survivors.


Eligibility criteria:
inclusion criteria: women will be eligible if they meet the following criteria: * self-identify as black or african american or afro-latina/e; * are ≥18 years old; * have a confirmed diagnosis of breast cancer, stage i to iiia; * have completed primary active treatment (i.e., surgery, chemotherapy, and radiation) within 5 years prior to study start where concomitant hormonal therapy is acceptable; * are not meeting current cancer-specific resistance exercise guidelines of ≥ 2 times per week; and * are able to speak and understand english. exclusion criteria: * metastatic disease; * medical reason that precludes them from increasing current exercise levels; * planned elective surgery during study period; * pregnant or plans to become pregnant during the study period; * plans to move out of united states during the study period; (the rationale for this exclusion is that it will be difficult to conduct the in-person assessments if a participant leaves the united states); * current enrollment in another exercise trial; and/or * inability to pass exercise pre-screening or receive physician consent to increase current physical activity levels.
utrecht cohort for multiple breast cancer intervention studies and long-term evaluation - the umbrella cohort

Conditions: Breast Cancer

Summary: due to better treatment options and earlier detection, survival rates of patients with breast cancer continue to increase. as such, (late) treatment toxicity, (long-term) quality of life and the cosmetic outcome are becoming more important. also, many competing experimental interventions (e.g. treatment, lifestyle interventions) for breast cancer are being developed, all in need to be properly evaluated before being implemented in routine clinical care. randomized controlled trials are the gold standard to do so, but they have shown many challenges, especially when applied in a cancer setting. the 'cohort multiple randomized controlled trial (cmrct)' design is a promising design for multiple (simultaneous) randomized evaluations of experimental interventions, with potential for increased recruitment, comparability and long-term outcomes as a standard. by setting up umbrella, as a prospective cohort according to the cmrct design, the investigators aim to: * provide an infrastructure for efficient, fast and pragmatic evaluation and implementation of experimental interventions * gain insight into short and long-term treatment response, toxicity, complications, quality of life and survival of patients with breast cancer.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * patients with breast cancer who undergo irradiation in the umc utrecht * informed consent - at least - for use of routinely collected clinical data and to fill out questionnaires. exclusion criteria: * inability to understand the dutch language
photodynamic therapy in treating patients with skin cancer

Conditions: Non-melanomatous Skin Cancer

Summary: rationale: photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. photodynamic therapy using aminolevulinic acid cream may be effective in treating patients with skin cancer. purpose: this randomized phase ii trial is studying how well photodynamic therapy works in treating patients with skin cancer.

objectives: * characterize the penetration of topically applied aminolevulinic acid (ala) into the lesions of patients with primary basal cell and squamous cell carcinomas. * quantitate the depth of fluorescence achievable with varying application periods of ala in these patients. * compare the results of tissue fluorescence with surface fluorescence measurements in these patients. outline: this is a randomized study. patients are stratified according to lesion type (superficial basal cell carcinoma (bcc) vs nodular bcc vs squamous cell carcinoma). patients within each group are randomized to receive one of two application times: 4-5 or 20-24 hours in duration. aminolevulinic acid is topically applied either in a cream mixture or an alcohol base and an occlusive dressing placed over the lesion. after the randomized treatment duration has expired, the dressing is removed and quantitative protoporphyrin ix fluorescence measurements from the tumor and surrounding skin are mapped using a fluorometer. routine surgical excision is then performed on the carcinoma. patients return after one to two weeks for a follow-up examination and suture removal. projected accrual: 54 patients will be accrued within 10 years.

Eligibility criteria:
disease characteristics: * histologically proven basal cell carcinoma or squamous cell carcinoma * candidate for complete surgical excision patient characteristics: age: * 18 and over performance status: * not specified life expectancy: * not specified hematopoietic: * not specified hepatic: * not specified renal: * not specified other: * no inflammation or infection of treated area prior concurrent therapy: biologic therapy: * not specified chemotherapy: * not specified endocrine therapy: * not specified radiotherapy: * not specified surgery: * biopsy at least 2 weeks prior to surgery

Keywords: basal cell carcinoma of the skin squamous cell carcinoma of the skin