Kornimate/medical-research-clean huggingface dataset:
comorbid chronic lung disease on heart failure

Conditions: Comorbid Chronic Lung Disease on Heart Failure

Summary: comorbid chronic lung disease (cld) increases mortality in heart failure (hf) patients. understanding the predictors and pathophysiology of hf can improve the efficacy of hf treatment. this study evaluated the cardiopulmonary exercise test (cpet) results to identify significant predictors on long-term outcomes in hf patients with cld.

the cpet was administered in a cohort of 169 hf outpatients with exercise intolerance at a tertiary referral center between may 2007 and july 2010. a cld was defined as abnormal spirometry accompanied by clinical symptoms and signs included in the global initiative for chronic obstructive lung disease criteria. the primary endpoint was defined as cv mortality or the first hf hospitalization. totally 49 events occurred before the end of follow up in january 2018.

Eligibility criteria:
inclusion criteria: * outpatients ≥ 18 years of age, male or female. * patients with a diagnosis of heart failure with clinical symptoms and echocardiography evidence * patients received cardiopulmonary exercise test exams exclusion criteria: * cannot tolerance exercise test due to muscular-skeletal disorder * cannot co-operate all functional studies * family reject to participate in this project
use of novel plasma and urinary biomarkers to predict the development of hepatorenal syndrome in cirrhotic patients

Conditions: Hepatorenal Syndrome

Summary: this study investigated the use of novel plasma and urinary biomarkers to predicte the development of hepatorenal syndrome in patients with advanced cirrhosis. the biomarkers investigated include plasma cystatin c, plasma ngal, plasma nag, plasma il-18, plasma adma, plasma btp, urinary kim-1 and urinary lfabp. these biomarkers will be checked in advanced cirrhotic patients who have or have not developed hepatorenal syndrome and compared between the two groups. these biomarkers will also be correlated with the occurence of hepatorenal syndrome.

this study investigated the use of novel plasma and urinary biomarkers to predicte the development of hepatorenal syndrome in patients with advanced cirrhosis. the biomarkers tested include plasma cystatin c, plasma ngal, plasma nag, plasma il-18, plasma adma, plasma btp, urinary kim-1 and urinary lfabp. these biomarkers will be checked in advanced cirrhotic patients who have or have not developed hepatorenal syndrome and compared between the two groups. these biomarkers will also be correlated with the occurence of hepatorenal syndrome.

Eligibility criteria:
inclusion criteria: * patients with advanced cirrhosis (child's b or c) referred for liver transplantation * willing to give informed consent exclusion criteria: * patients with co-existing renal diseases
outcomes of group dance and movement training in ambulatory ms patients

Conditions: Multiple Sclerosis

Summary: groundworks dancetheater and cleveland clinic are partnering to create and offer an initial study of a dance movement-based community program for people with multiple sclerosis (ms). the program will address major needs in the ms community including social-emotional well-being, body awareness, and motor function. groundworks artists will use a variety of widely accepted movement-based practices with the goal of improving upper and lower body function and overall well-being. by partnering, groundworks and cleveland clinic hope to encourage more study of the benefits of dance movement-based programming in individuals affected by ms.

groundworks dancetheater and cleveland clinic are partnering to design and implement a pilot study of a dance movement-based community program for people with multiple sclerosis (ms). the program is aimed at addressing major needs in the ms community including social-emotional well-being, body awareness, and motor function. groundworks artists will use a variety of movement-based practices including personalized tasks and imagery, mirroring, and inscription, with the goal of improving upper and lower extremity function, and well-being. cleveland clinic will assist groundworks in the selection, monitoring, and testing of the participants. cleveland clinic will also take the lead with data management and analysis. by partnering, groundworks and cleveland clinic hope to create a promising program that will lead to further exploring the impact of dance movement-based programming in individuals affected by ms.

Eligibility criteria:
inclusion criteria: * age 18 to 65 inclusive * diagnosis of ms (relapsing or progressive form) based on the revised macdonald criteria established by a neurologist * self-reported upper and lower extremity dysfunction * ability to walk safely without an assistive device (e.g. cane, walker) indoors and outdoors exclusion criteria: * comorbidity (e.g. cardiac, respiratory, musculoskeletal) representing a contra-indication to the dance movement program * exacerbation of ms within the past 60 days * severe cognitive impairment * clinically significant concern regarding the participant's ability to safely perform study procedures

Keywords: dance movement
phace - prospective genetic investigation

Conditions: PHACE Syndrome

Summary: investigation for potential phace syndrome gene.

subjects with phace syndrome diagnosis will undergo a brief physical examination with possible external photographs. cheek swabs will be sent for genetic analysis. subjects will be notified of the results.

Eligibility criteria:
inclusion criteria: * phace syndrome diagnosis * must be willing to have an eye examination * must be willing to undergo genetic testing exclusion criteria: * no phace syndrome diagnosis
development of a new immunochemistry method using antibodies of proteins related bile duct cancer

Conditions: Bile Duct Obstruction, Extrahepatic

Summary: the sensitivity of brushing cytology used to distinguish the cause of biliary strictures is low and clinical usefulness is not secured. the aim of this study was to develop a new differential staining method for cytology which is difficult to differentiate by the conventional staining method using biliary cancer related protein expressed only in bile duct cancer.

hypothesis: the statistical significance of new staining method using aminoacyl-trna synthetases (arss) group in normal bile duct cells and the bile duct cancer cells collected by endoscopic retrograde pancreaticoduodenoscopy (ercp) will be compared to prove the usefulness of the new staining method. clinical study design: the bile duct cytology will be obtained by brushing cytology using ercp in patients with biliary stenosis. the expression of arss in the brushing cytology will be evaluated by new staining method and compare with the results of conventional cytology staining method including papanicolaou staining. immunofluorescence or immunohistochemistry staining will be performed to differentiate the presence of the tumor. the sensitivity and specificity of the new staining method will be compared with the conventional staining method and its usefulness be confirmed.

Eligibility criteria:
inclusion criteria: * patients with biliary cancer confirmed by imaging (ct, mri, positron emission tomography) * patients with bile duct cancer diagnosed using brushing cytology by endoscopic retrograde pancreaticoduodenoscopy * patients who underwent surgical treatment with biliary cancer * patients with bile duct stenosis exclusion criteria: * minors under the age of 19, vulnerable subjects such as illiteracy * necrotic specimens * samples with non-diagnostic cytology results and insufficient cells for further evaluation * samples classified as neoplastic (benign or other) * patient with cholangitis in the bile duct

Keywords: bile duct obstruction, extrahepatic cytology aminoacyl-trna synthetases
the effects of an intensive lifestyle intervention for type 2 diabetes on disability insurance

Conditions: Diabetes Mellitus Type 2

Summary: starting in 2001, the look ahead study randomized patients with type 2 diabetes to an intensive lifestyle intervention (ili) focused on weight loss versus a control group receiving diabetes education ("diabetes support and education"). the ili successfully reduced weight, improved diabetes control, and functional status, among other outcomes. in this study, the investigators will compare participation in federal disability insurance programs between the ili and the control group during and after the intervention period (2001-2017).

starting in 2001, the look ahead study randomized 5145 patients with type 2 diabetes to an intensive lifestyle intervention (ili) focused on weight loss versus a control group receiving diabetes education ("diabetes support and education").the look ahead study tested whether participants with type 2 diabetes assigned to an intensive lifestyle intervention (ili) for weight loss exhibited reductions in cardiovascular morbidity and mortality, relative to a control group receiving usual care and diabetes support and education. during the 12-year intervention period, the ili led to persistent reductions in weight, waist circumference, and hemoglobin a1c and improvements in physical fitness, among other clinical benefits. after the conclusion of the intervention in 2012, participants were consented to be linked with administrative data. the investigators attempted to link 3188 consenting participants with social security administration databases. of these, the investigators were able to successfully link 3093 participants. in this study, the investigators will compare participation in federal disability insurance programs including social security disability insurance (ssdi) and disability-related supplemental security income (ssi) between the linked ili and the control group during and after the intervention period (2001-2017). the investigators will investigate ili-versus-control differences in whether participants ever applied or received benefits from ssdi and ssi. the investigators will also investigate ili-versus-control differences in applications and benefit receipt in each year after randomization, relative to a pre-randomization assessment period. the investigators will use both multivariate regression controlling for baseline participant characteristics and clinic site and also survival analyses that estimate whether the time until ssdi or ssi application or benefit receipt differs between the ili and control groups.

Eligibility criteria:
(note: age limits above are at time of randomization, which occurred between 2001-2004) inclusion criteria: * look ahead participation: met age requirements and other criteria at time of study enrollment which occurred between 2001-2004 (as noted in look ahead research group (2013)) * consented to administrative data linkages * provided individual identifiers that could be linked with ssa databases * were successfully linked to ssa data exclusion criteria: -
this study uses the sits registry to find out when patients with a heart rhythm disorder (atrial fibrillation) start treatment with dabigatran after they had a stroke

Conditions: Atrial Fibrillation

Summary: this is an observational study in patients with non-valvular atrial fibrillation (nvaf) presenting to the hospital with a first acute ischemic stroke based on existing data recorded in the sits international registry (located in sweden) by physicians in several european countries, such as italy, united kingdom, czech republic, sweden, germany, poland, spain, finland, portugal, slovakia, denmark, estonia, norway belgium, hungary, slovenia, croatia, austria, lithuania, france, greece, netherlands, ireland, ukraine and iceland. the aim of this study is to explore the current real world use of dabigatran for stroke prevention in nvaf patients in the post-stroke setting. secondary data from eligible european patients registered in the sits registry will be considered; countries of origin are not known a priori.


Eligibility criteria:
inclusion criteria: * patients with non-valvular atrial fibrillation (nvaf) * patients presenting with their first acute ischemic stroke * ≥18 years of age exclusion criteria: - documentation that the patient was enrolled or is planned to be enrolled in an investigational clinical trial at the time of the onset of the index event and for the duration of the data collection
the association of psychological stress with the efficacy of neoadjuvant therapy in breast cancer

Conditions: Breast Cancer

Summary: this study aims to explore the relationship between psychological stress and the therapeutic response in breast cancer patients who have received standard neoadjuvant chemotherapy.

breast cancer is the most common malignant tumor among women. approximately 19% to 30% of patients with breast cancer achieve a pathological complete response (pcr) following neoadjuvant therapy, while about 5% to 20% of patients experience disease progression. increasing evidence suggests the significant role of psychological factors in influencing cancer treatment outcomes. cancer patients often experience emotional distress, including fear of relapse, anxiety, depression, and low self-esteem, which may persist for many years. statistics indicate that the incidence of anxiety and depression among cancer patients is 49.69% and 54.90%, respectively, significantly higher than that of healthy individuals (anxiety: 18.37%, depression: 17.50%) in china. there are indications that emotional issues may be linked to cancer treatment, although the underlying mechanisms remain unclear. this study aims to investigate the relationship between anxiety and depression and the effectiveness of standard neoadjuvant therapy in patients with breast cancer.

Eligibility criteria:
inclusion criteria: * 1.age ≥ 18 years; 2.histological and/or cytological diagnosis of breast cancer; 3.treatment niave patients; 4.to receive standard neoadjuvant therapy; 5.eastern cooperative oncology group (ecog) performance status of 0-1; 6.presence of at least one measurable lesion according to the response evaluation criteria in advanced solid tumors version 1.1 (recist v1.1) ; 7.informed and agreed to participate in the study; exclusion criteria: * 1. breast cancer has not been confirmed through histological or cytological examinations. 2.other breast cancer conditions that do not receive neoadjuvant therapy. 3.combined with other malignant tumors. 4.concurrent acute or chronic psychiatric disorders, along with having received antidepressant or anti-anxiety therapy within the past month. 5.participants must not have engaged in any other clinical trials in the past month, unless those trials are observational or non-interventional in nature.

Keywords: psychological stress, breast cancer
multi-center pilot study of cutera trusculpt device

Conditions: Treatment for Cellulite on the Stomach and Flanks

Summary: exploratory study to evaluate the safety, efficacy and ergonomics of cutera trusculpt device.

this study will evaluate the safety, efficacy and ergonomics of cutera trusculpt device.

Eligibility criteria:
inclusion criteria: * 1. subject must be able to read, understand and sign the informed consent form. 2. female or male, 18 to 65 years of age (inclusive). 3. subject has visible fat bulges in the area to be treated. 4. non-smoking for at least 6 months and willing to refrain from smoking for the duration of the study. 5. subject must agree to not undergo any other procedure(s) in the treatment region during the study period. 6. subject must adhere to the follow-up schedule and study instructions. 7. subject must adhere to the same diet and/or exercise routine throughout the study, and agree to maintain the same weight throughout the study. 8. willing to have photographs taken of the treatment area and agree to use of photographs for presentation, (educational and/or marketing), publications, and any additional marketing purposes. 9. for female subjects: not pregnant or lactating and is either post-menopausal, surgically sterilized, or using a medically acceptable form of birth control prior to enrollment and during the entire course of the study. exclusion criteria: 1. participation in a clinical trial of another device or drug within 1 month of study participation, or during the study period. 2. any type of prior cosmetic treatment to the target area within 6 months of study participation. 3. any prior invasive cosmetic surgery to the target area, such as liposuction. 4. has a pacemaker, internal defibrillator, implantable cardioverter-defibrillator, nerve stimulator implant, cochlear implant or any other electronically, magnetically or mechanically activated implant. 5. has metal implant(s) within the body, such as artificial heart valves. 6. significant uncontrolled concurrent illness that in the opinion of the investigator would make the subject unsuitable for inclusion. 7. history of any disease or condition that could impair wound healing. 8. history of keloid formation, hypertrophic scarring or abnormal/delayed wound healing. 9. skin abnormality in the treatment area that in the opinion of the investigator would make the subject unsuitable for inclusion. 10. currently undergoing systemic chemotherapy or radiation treatment for cancer, or history of treatment in the target area within 3 months of study participation. 11. allergy or sensitivity to tegaderm. 12. as per the investigator's discretion, any physical or mental condition which might make it unsafe for the subject to participate in this study or a condition that would compromise the subject's ability to comply with the study requirements.
graphene oxide in the surgical management of intrabony periodontal defects

Conditions: Periodontal Diseases

Summary: using graphene oxide in the surgical management of periodontal intrabony defects.

evaluation of the effect of graphene oxide in the surgical management of periodontal intrabony defects in animals in periodontal clinical parameters with histomorphometric evaluation .

Eligibility criteria:
inclusion criteria: * male dogs * 12-24 months old with approximate weight of 20-30 kg and general good health will be used exclusion criteria: -
a behavioral intervention for depression and chronic pain in primary care (relief-hybrid)

Conditions: Chronic Pain; Depression

Summary: chronic pain and depression frequently co-exist in late and mid-life and contribute to increased disability, high health care costs, psychiatric comorbidity, and suicide. older and middle-aged depressed-pain patients: a) are mainly treated in primary care practices; and b) are often prescribed medication, which increases the risk for addiction to opioids and benzodiazepines. despite the need and desire by the patients and providers for primary care behavioral intervention, behavioral interventions are scarce in primary care. to address this need, relief-hybrid was created. subjects are randomized to either the relief-hybrid intervention or to referral to mental health/usual care. subjects in both arms will complete research assessments at 6, 9, and 12 weeks. subjects in the relief-hybrid arm will receive 5 weekly sessions with the study therapist (licensed social workers, lcsws) and 4 self-administered, mobile technology-assisted sessions.


Eligibility criteria:
inclusion criteria: * 50 years or older * phq-9 score greater or equal to 10 * chronic pain (non-cancer related, most days over the past 3 months) * capacity to consent exclusion criteria: * dsm-5 axis 1 diagnoses other than depression and anxiety disorders * montreal cognitive assessment (moca) \< 24 * active suicidal ideation (madrs item #10 greater or equal to 4 * severe or life-threatening medical illness * patients on psychotropics, opioids or benzodiazepines will be included if they do not meet dsm-5 criteria for opioid, anxiolytics or other substance abuse disorders

Keywords: chronic pain depression primary care older adults middle aged
growth, dietary intakes and feeding behaviors of children with cerebral palsy who have chewing disorders

Conditions: Cerebral Palsy; Mastication Disorder; Malnutrition; Growth Delay

Summary: the nutritional status of cp children may be decreased when children have chewing disorders too due to insufficient solid food intake. the objective of this study was to investigate growth, dietary intakes and feeding behaviours of children with cp who have chewing disorders, and to compare them with their healthy peers.

chewing function is defined as a rhythmic oral motor activity to comminute and soften solid food. children with cp often have difficulty in transitioning to solid food. the main food of 45% of them was liquids and semisolids. it was reported that food/fluid textures were modified for 39% of children in which with poorer gross motor function tended to receive a greater proportion of energy from fluids in their diets and fewer chewable foods. lopes et al. investigated dietary patterns of 90 children with cp aged 2-13 years by using the 24-hour recall method and found that 26% and 9% of children had difficulty in chewing and swallowing of solid foods, respectively. however, the diet of children with normal feeding skills includes liquid, semisolid and/or solid foods together so unable to take any solid food may affect sufficient food intake and nutritional status of children with cp who have chewing disorders. the significance of this situation is that nutritional status has effects on general health and quality of life of children and their families. therefore, it is important to show the nutritional status of cp children with chewing disorders to increase the awareness of both parents and healthcare providers on solid food intake and solve the problem early. the objective of this study was to investigate growth, dietary intakes and feeding behaviours of children with cp who have chewing disorders, and to compare them with their healthy peers.

Eligibility criteria:
inclusion criteria: study group * children with cerebral palsy * having complaints about chewing function * do not manage solid food intake * above the age of 18 months control group * healthy children * no complaints about chewing function * can manage solid food intake * above the age of 18 months exclusion criteria: * under the age of 18 months * requiring tube feeding or taking any oral nutritional supplements * using any medicine and/or oral appliances that could affect the chewing performance