Kornimate/medical-research-clean huggingface dataset:
the effect of live subject on the anxiety level and perceived competence level

Conditions: Anxiety Level

Summary: this study was carried out to examine the effect of training on the proficiency and anxiety levels of paramedic students in a realistic, simulated environment of the pre-hospital scene. a total of 72 second-year students in the paramedic program participated in this study with an interventional approach. the data collection form used in the study consisted of sociodemographic characteristics, a self-efficacy form for approaching trauma patients, and the worry and anxiety scale. within the framework of the research, a competition named "trauma rally" was organized for university paramedic students, which consisted of the pre-hospital approach of injured live subjects. through face-to-face interviews, the data collection form was filled out with the participants before, immediately after and one month after the competition.

teaching-learning strategies are methods to make it easier for the student to achieve professional goals in personal development. in the context of the academic education of healthcare professionals, ethical issues, patient safety, technological developments, health science, complexity of care measurements and current business world necessities should be taken into account by considering these strategies. in this context, simulation-based learning is one of the most effective and interesting teaching strategies and has been shown to reduce gaps between education and practice and adapt nursing students to clinical environments. simulation is a set of structured activities that represent actual or potential situations in training and practice. these activities allow participants to develop or increase their knowledge, skills and attitudes, or to analyze and respond to realistic situations in a simulated environment. simulations are especially important in clinical environments because they imitate various aspects of the real world and provide safe learning environments where students can practice until they reach skill competence through self-correction. as a matter of fact, the european heart association (erc) points out that simulation programs increase the quality of trauma and advanced life support training and increase resuscitation rates after cardiac arrest. high fidelity simulation-based training can be an important component in preparing students for a successful transition into clinical practice. additionally, it contributes to student satisfaction, confidence, competence and reduced anxiety levels. for these reasons, simulated experiences may be an option to complement traditional healthcare professional education methods.

Eligibility criteria:
inclusion criteria: * volunteering exclusion criteria: * non volunteering

Keywords: simulation paramedic anxiety competence
dose escalation with sib to intraprostatic/lymphatic gtv in high risk prostate cancer

Conditions: Prostatic Neoplasms; Lymphatic Metastasis

Summary: a single arm phase 2 study to study the outcome of dose-escalation with simultaneous integrated boost to intraprostatic lesion and positive lymph nodes. prostate cancer patients with high risk of lymph node metastasis or oligo positive nodes in true pelvic area can be included. the boost volumes will be outlined by usin pet-ct and mri data. our hypothesis is that we will have fewer relapses in this very high risk patient group compared to matched historical controls with acceptable side effects.


Eligibility criteria:
inclusion criteria: * histologically confirmed high risk prostate cancer with a risk of lymphatic spread \>15% according to the mskcc nomogram (1) http://nomograms.mskcc.org/prostate/pretreatment.aspx * written informed consent * \> 18 years * fiducial gold markers implanted in the prostate (min 3) exclusion criteria: * • non mr-safe implants or other contraindication to mri * who ps\>1 * previous pelvic irradiation * turp within 6 months * ipss \>19 * metastatic disease in skeleton, parenchymal organs or lymph nodes outside the pelvis * creatinin clearance \< 30ml/min according to http://www.fass.se/lif/produktfakta/kreatinin.jsp

Keywords: quality of life radiotherapy radiotherapy, dose-escalation
effects of light intensity physical activities on pre-frontal cortical activation, cognitive function, sleepiness and back pain

Conditions: Pre-frontal Cortical Oxygenated and Deoxygenated Hemoglobin Levels

Summary: the objective of this randomised controlled trial is to examine the acute effects of two novel light intensity exercise (sit-cycling and stand-twisting) on prefrontal cortical blood oxygenation, executive functioning, sleepiness and back pain among inactive university students. the main questions it aims to answer are: * what are the changes in oxygenated haemoglobin (o2hb) and deoxygenated hemoglobin (hhb) levels in the prefrontal cortex from baseline to immediately after and 20 minutes after a 5-min bout of s-c and s-t compared to sitting for the same duration? * what are the changes in executive functioning, specifically, n-back test and word colour stroop test performance from baseline to immediately after and 20 minutes after a bout of s-c and s-t compared to sitting for the same duration? * how does participants' self-rated daytime sleepiness and back pain after a bout of s-c and s-t compare to sitting for the same duration? participants will: * perform sit-cycling or stand-twisting for 5 mins (experimental condition) and sit for 5 mins (control condition) * wear the functional near-infrared spectroscopy cap on their head throughout the measurements * complete 1-back, 2-back test and word colour stroop before, immediately after and 20 minutes after experimental/ control condition * have their blood pressure, heart rate taken by a smartwatch * complete a daytime sleepiness questionnaire and a back pain questionnaire


Eligibility criteria:
inclusion criteria: * ntu-nie university student, between 21 and 30 years old, do not meet physical activity guidelines (150 mins of weekly mvpa) exclusion criteria: * taking blood-pressure lowering medication * physically active (150 mins or more of weekly mvpa) * deemed not physically fit to participate in physical activity based on responses to get active questionnaire

Keywords: light-intensity exercise pre-frontal cortical activation executive functioning university students inactive
role of wound irrigation after appendectomy

Conditions: Appendicitis

Summary: surgical site infection is a common problem after open appendectomy. irrigation of the surgical wound by topical antibiotics has been devised as a measure to reduce the incidence of wound infection. the present trial aims to assess the efficacy of layer-by-layer wound irrigation with gentamicin-saline solution in prevention of superficial surgical site infection after open appendectomy for acute uncomplicated appendicitis.


Eligibility criteria:
inclusion criteria: * adult patients of both genders aging between 18 and 65 years who present with acute appendicitis. * patients with perforated appendicitis will be also included. exclusion criteria: * patients with appendicular mass, appendicular abscess, generalized peritonitis. * patients with other causes of acute abdomen as revealed intraoperatively. * patients taking long course of steroid therapy or immunosuppressive treatment, * patients unwilling to participate in the trial.
clinical registration study of patients with intracranial / carotid stenosis

Conditions: Cognitive Function; Stenosis

Summary: through prospective registration and follow-up, this study will collect data of patients with intracranial/carotid stenosis, including clinical information, neuropsychological scales, multimodal magnetic resonance images. the investigators aim to analyze clinical and imaging characteristics of patients with cognitive impairment related to intracranial/carotid stenosis, in order to achieve early identification of cognitive impairment.


Eligibility criteria:
inclusion criteria: * patients aged ≥ 40 years * ≥ 50% stenosis in unilateral intracranial / carotid artery * written informed consent available exclusion criteria: * previous history of major head trauma and any intracranial surgery * intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions * extrapyramidal symptoms or mental illness which may affect neuropsychological measurement * severe loss of vision, hearing, or communicative ability exit criteria: * not meet the inclusion criteria * for any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator * any adverse or serious adverse events during the study period judged by investigator

Keywords: cognitive function intracranial / carotid stenosis
risk factor for readmission and death of lower respiratory infections in older adults

Conditions: Lower Respiratory Infection; Anemia; Readmission; Death

Summary: lower respiratory tract infection(lrti) is a prevalent disease that threatens the health of older people worldwide. anemia is also a common disorder in the elderly, and its prevalence increases significantly with age. most factors that contribute to the development of anemia are improvable. therefore, we investigated whether anemia was a risk factor for lrti-caused readmission and death in the elderly occurring within 1 year of discharge from the hospital.

objectives: to investigate the effect of anemia on readmission and deaths in the older adults following lower respiratory tract infection (lrti)-caused hospitalization. design: a retrospective cohort study. setting and participants: older patients (age: ≥ 80 years) hospitalized at the department of geriatrics, from march 2016 to december 2019 to undergo treatment for lrtis were included. methods: the patients were divided into two groups (anemia and non-anemia) based on the level of hemoglobin. they were kept under observation till the occurrence of mortality event or 1 year after discharge. the primary follow-up outcome was lrti-caused readmission and/or death.

Eligibility criteria:
inclusion criteria: * age ≥ 80 years * lower respiratory tract infection exclusion criteria: * died at the time of first admission * active malignancy * tuberculosis * anemia caused by gastrointestinal bleeding of unknown origin * achalasia of the cardia * could not be followed up after discharge * data were missing
satiety response of four dietary fibers

Conditions: Healthy

Summary: studies have found a relationship between dietary fiber consumption and body weight regulation. this relationship may stem from enhanced satiety through fermentation of certain fibers in the large intestine. the objective of this study is to determine and compare satiety ratings, changes in food intake, and gastrointestinal effects for four fibers: fructooligosaccharide, inulin, soluble corn fiber, and resistant starch.


Eligibility criteria:
inclusion criteria: * healthy women * age 18-40 years * nonsmoking * not taking weight loss medications * non-dieting (weight has not changed more than 11 pounds over three months) * bmi between 18.5 and 29 * spoken and written english literacy exclusion criteria: * do not regularly consume breakfast * food allergies to wheat, soy, peanut, or dairy * bmi less than 25 or greater than 29 upon admission to study * cancer diagnosis in past 5 years * history of heart disease, kidney disease, diabetes, or eating disorder * history of ulcerative colitis, crohn's disease, or any other gastrointestinal condition * history of drug or alcohol abuse in past 6 months * use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication * concurrent or recent (within 30 days) intervention study participation * pregnant or lactating * irregular menstrual cycle * vegetarians * people who eat more than approximately 15 grams of fiber per day

Keywords: adult women dietary fiber satiety response food intake
an imaging study to investigate the distribution of gw842166x in the brain.

Conditions: Pain, Inflammatory

Summary: gw842166x is being developed for the treatment and management of inflammatory pain. gw842166x is a cb2 receptor agonist and the mechanism is not fully understood, although it is thought that for the anti-inflammatory action the drug is required to cross inot the brain from the blood. this study aims to look at if the drug crosses into the brain once given orally using an imaging technique called positron emission tomography.


Eligibility criteria:
inclusion criteria: * male aged 50 to 80yrs inclusive at the screening visit. * subjects with negative hiv and hepatitis b and c test results within 3 months of study start. exclusion criteria: * a negative allens test on arm to be used for arterial cannulation. * any contraindications to mri scanning. * history or presence of hepatic or renal disease. * previous involvement in pet or radiological investigations. * family history of cancer. * history of claustrophobia * presence of a cardiac pacemaker or any other electronic device or ferromagnetic metal

Keywords: brain, inflammation, cb2, pet analgesia,
effects of a supervised rehabilitation program on disease severity in spastic ataxias

Conditions: Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay; Spastic Paraplegia 7

Summary: spastic ataxias are a group of diseases causing symptoms such as walking difficulties and balance impairments that lead to a high risk of falls. no pharmacological treatments exist to treat these diseases. unfortunately, little effort is made to develop non-pharmacological treatments specific to spastic ataxias despite the detrimental impact of the disease on several aspects of an individual's life and the high cost of falls for society each year. the three objectives of this project are: 1) to determine the effect of a 12-week rehabilitation program on disease severity as compared with usual care for individuals with spastic ataxias; 2) to identify which factors can help (or not) the implementation of the program in the clinical settings ("reel world"); and 3) to explore the cost-benefits of impact \[rehabilitation program for spastic ataxias\]. the team has developed the program to specifically target symptoms present in these patients and was previously pilot-tested. based on the results obtained in this pilot project, positive effects are expected concerning the disease severity of participants. the investigators want, with this project, provide to health care professionals an option to offer better-suited services to people living with spastic ataxia worldwide.


Eligibility criteria:
inclusion criteria: * have a confirmed genetic diagnosis of arsacs or spg7 * be able to maintain standing position and to transfert * be authorized by their treating neurologist * speak french or english * be able to give informed consent. exclusion criteria: * have active participation in a rehabilitation program (self-reported information) * have another condition causing physical limitations * be uncomfortable in a swimming pool * be pregnant.
awareness trial (awareness) of storytelling through music in healthcare workers

Conditions: Stress; Post Traumatic Stress Disorder; Work Related Stress

Summary: this research study is examining the feasibility and effectiveness of an online version of the storytelling through music (stm) program with oncology nurses who have worked during the covid-19 pandemic.

this study employs a two-group, randomized controlled trial design that will utilize quantitative and qualitative methods to evaluate the feasibility and intervention effect of an alternative delivery (online) of the storytelling through music program (stm). previous study of in-person delivery of storytelling through music program stm with oncology nurses found it to be feasible and beneficial to coping with stress and work-related emotions. the research study procedures include: screening for eligibility and study intervention including follow-up surveys. participants will be randomized into two (2) groups: storytelling through music (stm) and waitlist (storytelling through music-hybrid) stm group: participants are led through a writing workshop over an online platform (i.e., zoom or an equivalent) to develop their story. simultaneous with the writing sessions are 10-minute self-care lessons. at the end of the development workshop, each participant will be paired with a songwriter who will turn participant stories into songs. a final workshop will be held for participants to debrief about the emotional experience of participating in the storytelling through music program (stm) waitlist control group (storytelling through music-hybrid), will listen to songs created by healthcare workers in the storytelling through music program (stm) for 2 weeks. participation length will be based on the randomized group assignment, a total of 19 weeks for the stm group and 13 weeks for the waitlist group. it is expected that about 50 people will take part in this research study.

Eligibility criteria:
inclusion criteria: * the inclusion criteria for the study is as follows: a) \>18 years old; b) licensed oncology nurse; c) provided direct patient care during covid-19 pandemic. exclusion criteria: * key exclusion criteria include: a) have previously participated in the stm intervention.

Keywords: stress post traumatic stress disorder work related stress
effects of different physical therapy programs on pulmonary rehabilitation in patients with lung cancer

Conditions: Rehabilitation

Summary: this study applies external diaphragm pacemaker and positive expiratory pressure therapy to patients who received thoracic surgeries, in order to explore the effects of different physical therapy programs on pulmonary rehabilitation in patients with lung cancer. as well as we hope that these physical training programs can effectively improve the lung function of patients, reduce postoperative pulmonary complications, hospitalization days, hospitalization expenses, etc.

this study applies external diaphragm pacemaker and positive expiratory pressure therapy to patients who received thoracic surgeries, ninety patients may be enrolled in this study. some metrics are used to evaluate the pulmonary rehabilitation status in postoperative patients which include pulmonary function test, 6-min walking test，borg index, complications incidence, chest tube draining time, and diaphragm muscle mobility.

Eligibility criteria:
inclusion criteria: 1. patients who are diagnosed with non-small cell lung cancer with clear pathological cytology by fiberoptic bronchoscopy and ct, and plan to undergo lobectomy or segmentectomy under general anesthesia for tracheal intubation; 2. age 18-80 years old; 3. those who have stable vital signs and can participate in this research; 4. pulmonary function test fev1/fvc\>0.8. 5. volunteer to participate in this research and sign an informed consent form. exclusion criteria: 1. pneumonectomy patients; 2. wedge resection patients 3. patients with distant metastasis of cancer; 4. patients with other malignant tumors; 5. severe complications occurred during the operation, and respiratory function training and testing are not allowed before and after evaluator; 6. patients with severe physical or mental illness who cannot cooperate with the test; 7. patients with pacemakers, active tuberculosis, and pneumothorax.

Keywords: pulmonary rehabilitation external diaphragm pacemaker expiratory pressure therapy
discovery of biomarkers for intrinsic radiation sensitivity in cancer patients

Conditions: Nasopharyngeal Cancer; Prostate Cancer; Other Cancer

Summary: patients with cancers that are sensitive to radiotherapy treatment and/or patients who have experienced severe acute/ late side effects to radiotherapy will be recruited to the study. blood and/or matched tumour-normal tissue pairs will be collected. blood and/or tissue samples will be processed and studied for genetic and biochemical markers that have potential to be used for predicting sensitivity to radiation.


Eligibility criteria:
inclusion criteria: * patients with severe side effects from radiotherapy * patients with a type of cancer that is associated with sensitivity to radiotherapy exclusion criteria: * age of patient must be between 21 (inclusive) and 99 (exclusive)

Keywords: radiotherapy biomarkers genomics immunomics precision medicine
surgical evaluation of fixation of hand metacarpals fractures with k-wires

Conditions: Metacarpal Fracture

Summary: different techniques have been described forfracture fixation ofmetacarpals fracture withk-wires being the most described technique as it is minimally invasive methodsfor metacarpals fractures in this research ,we are aimingto evaluate k-wire fixation of metacarpal fracture to optimize the clical outcome as regardsto the degree of stiffnessas avouding the impairment of the gluding tissue of the fingers

hand fractures is about 19%of all fractures k-wires fixation is the most frequently method operative procedure which provide operative stability,early mobilization and excellent functional results primary option for fixation of theses fractures include k-wires ,plateand screws and more recently headless intramedullay compression scres and bouquet k -wire technique aim of work fir evaluation of the clinical,functional and radiological outcome of metacarpals fractures fixed by k -wires with variious techniques as antigrade intramedullay k-wires,transverse pinning of unstable displaced shaft and neck fractures. also direct orif for intra articular head fractures materials and methods we are analyzing all patients with metacarpals fractures except patients abnormal hands fuctions before injury procedure done under general anesthesia ,brachial plexus block and wrist block outcome and evaluation handgrip strength 3 month after surgery geniometer for range of motion ap ,lateral and oblique radiograph

Eligibility criteria:
inclusion criteria: * all patients with metacarpal fracture exclusion criteria: * patients with abnormal hand function before surgery