Kornimate/medical-research-clean huggingface dataset:
comparison of non-invasive to invasive assessment of jugular venous pressure

Conditions: Heart Failure; Congestion

Summary: assessment of the jugular venous pressure (jvp) is an important clinical sign and correlates with right atrial (ra) pressure. a patient with heart failure (hf) typically has an elevated jvp, but in cases of dehydration jvp may be low. assessment of the jvp is key to the management of patients with fluid overload or needing diuretics. currently the assessment of jvp is made by the physician by direct visualization of the neck veins. however this is inaccurate, may vary between investigators and depends largely on the patient's habitus. the jvp and ra pressures may also be directly measured by catheterization (a routine during right heart catheterization), but this is an invasive procedure that is seldom performed. a thermal movie of the external jugular vein at a specific neck position may help to measure the jvp. in this study different modalities of jvp assessment (clinical assessment, thermal image and invasive measurement) are to be compared patients scheduled for right heart catheterization at the shaare zedek medical center for non-study related medical indications will be approached. non-invasive estimates of jvp will be performed independently prior to the right heart catheterization, during the waiting period (within 2 hours) prior to catheterization. these will include up to 2min of thermal camera recording (to be analysed offline) and a physician's jvp evaluation. the angle of the patient's upper body will be 30-60°, the rotation of the neck will be optimal for filming, and the neck area may be cooled to enhance the images. blinding to the results will be confirmed by performance with separate investigators and separate data registration. right heart catheterization will then be performed and ra pressure will be recorded, as well as pulmonary and wedge pressures. jvp measured by physician and thermal image will be matched with invasive catheterization (the gold standard) using bland altman plots and spearmann correlation and comparison between methods will be performed.


Eligibility criteria:
inclusion criteria: 1. patients already scheduled for right heart catheterization for clinical indication 2. age 18-90 exclusion criteria: 1. local scar wound or bruise in the right side of the neck. 2. current upper torso central venous catheterization such as a picc line or dialysis catheter.
a phase ii study of efficacy and safety in patients with locally advanced or metastatic basal cell carcinoma

Conditions: Basal Cell Carcinoma

Summary: this study assessed the efficacy and safety of oral treatment with two dose levels of lde225 in patients with locally advanced or metastatic bcc.


Eligibility criteria:
inclusion criteria: * patients with locally advanced bcc and metastatic bcc * patients with adequate bone marrow, liver, and renal function exclusion criteria: * patients who had had major surgery within 4 weeks of initiation of study medication * patients unable to take oral drugs or with lack of physical integrity of the upper gastrointestinal tract, or known malabsorption syndromes. * patients with concurrent medical conditions that may interfere or potentially affect the interpretation of the study. * patients with neuromuscular disorders or are on concurrent treatment with drugs that may cause muscle damage. * patients who were on concurrent therapy with other anti-neoplastic agents. * patients who had taken part in an experimental drug within 4 weeks of initiation of study medication. * pregnant or nursing (lactating) women * women of child bearing potential unwilling to use 2 forms of highly effective contraception throughout the study and for 3 months after the last treatment * fertile males not willing to use condoms throughout the study and for 3 months after the last treatment. * patients who were unwilling or unable to comply with the protocol.

Keywords: locally advanced basal cell carcinoma metastatic basal cell carcinoma lde225 sonidegib basel cell carcinoma (bcc) skin cancer basel cell carcinoma bcc
exploration of ejaculatory anatomy concept study (ejac study)

Conditions: Ejaculatory Dysfunction

Summary: ejaculatory dysfunctions (ed) are an important cause of postoperative dissatisfaction, which lead to a decrease in the intensity of orgasms in 50% of patients. ed is a cause for concern for almost a third of patients who need surgery. surgical techniques have been developed to limit the occurrence of postoperative ed, but their results remain heterogeneous. there are very few studies on the biomechanical anatomy of ejaculation. ejaculation is a complex phenomenon involving different structures and in particular the veru montanum. this is the key element in the emission of ejaculate within the prostatic urethra. in addition, there is a structure located in the resection zone of the prostate adenoma. it has therefore been suggested that its resection was a primary source of ed. a single observational study carried out in by gil vernet et al in 1994 evaluated on a single healthy 18-year-old volunteer the ejaculatory mechanism of expulsion using an endorectal probe recording the movements of the prostate, the bladder neck and of the proximal urethra during ejaculation. a contemporary study of the biomechanics of the ejaculatory expulsion phase could confirm and improve understanding of the involvement of anatomical structures. the results of our study aim to adapt surgical techniques aimed at limiting the risk of postoperative ed.


Eligibility criteria:
inclusion criteria: * affiliated subject or beneficiary of a social security scheme * subject agreeing to participate and having signed the free, informed consent. exclusion criteria: * subject with ejaculatory dysfunction * subject with urinary dysfunction * history of urinary or penile surgery * subject with untreated urinary tract infection * history of chronic prostatitis * pathology making it impossible to introduce the endorectal probe or the ureteroscope * history of colorectal inflammatory disease * recent intake (within 30 days) of drugs known to interfere with ejaculation * history of intolerance or allergy to any of the drugs used in the study * subject participating in another clinical study * adults under guardianship, curatorship or other legal protection; deprived of liberty by judicial or administrative decision; hospitalized without consent.
effects of instrument assisted soft tissue mobilization on delayed onset muscle soreness

Conditions: Musculoskeletal Pain; Soreness, Muscle; Musculoskeletal Disorder

Summary: the aim of our study is to investigate the effect of instrument assisted soft tissue mobilization therapy on delayed onset muscle soreness

joint range of motion, pressure pain threshold, edema, isometric muscle strength measurement, visual pain scale, two-point discrimination, biochemical measurements (muscle damage in blood (serum creatine kinase (cc), lactate dehydrogenase (ldh), myoglobin, its effects on aspartate aminotransferase (ast) and alanine aminotransferase (alt) and biomarkers of inflammation (interleukin-1 beta), carbonic anhydrase iii, and c-reactive protein, and at what time interval and after which treatment session in the process after delayed muscle pain formation. it is aimed to determine how it affects the parameters.

Eligibility criteria:
inclusion criteria: 1. the participant must be between the ages of 18-35, 2. no fear of needles, 3. having read and understood the informed voluntary consent form and agreeing to participate in the study. exclusion criteria: 1. having neurological or perception problems, 2. having any cardiovascular, pulmonary and metabolic disease, 3. any musculoskeletal injury in the last 6 months, 4. having a history of pain and surgery in the upper extremity, 5. participating in upper extremity weight training in the last 6 months, 6. exercise, caffeine and alcohol consumption, and drug use up to 12 hours before the study were determined as

Keywords: delayed onset muscle soreness, instrument-assisted soft tissue mobilization, recovery, eccentric exercise
bacteriotherapy in the treatment of covid-19

Conditions: COVID; Pneumonia; Diarrhea

Summary: in light of its high morbidity and mortality, coronavirus disease 19 (covid-19) pandemic spread is considered an unprecedented global health challenge. given the very limited therapeutic options available against severe acute respiratory syndrome - coronavirus-2 (sars-cov-2) epidemic at this time, the evaluation of new resources, designed in the first instance for other pathologies but potentially active against covid-19, represents a priority in clinical research. this is an observational, retrospective, non-profit study on the adjuvant use of bacteriotherapy in the early control of disease progression in patients affected by covid-19 and treated with the current standard of care on the basis of the interim guidelines of the italian society of infectious and tropical diseases. the main purpose of the study is to evaluate the effectiveness of bacteriotherapy in reducing the clinical impact of acute diarrhea, containing the progression of covid-19 and preventing the need for hospitalization in intensive care units.

italy was the first european country hit by the severe outbreak of the sars-cov-2 epidemic emerged from china, with a high morbidity and associated mortality. given the limited treatment options currently available, the search for resources capable of improving disease outcomes is fundamental for the management of patients systemic inflammation related to covid-19, dietary changes, and use of antibiotics are all variables that contribute to changes in the gut microbiota with significant impact on the disease outcomes. probiotic supplementation can help to correct these issues. moreover some strains of lactobacilli and bifidobacteria inhibit influenza virus, rhinovirus, respiratory syncytial virus, adenovirus, and pneumovirus .

Eligibility criteria:
inclusion criteria: * covid-19 diagnosis * symptomatic covid-19 * hospitalization in infectious diseases wards exclusion criteria: * pregnant * hospitalization in intensive care unit

Keywords: covid-19 pneumonia gut-lung axis microbiome
e-manage: a brief mhelath intervention for university students

Conditions: Distress, Emotional; Suicidal Ideation

Summary: this study is a two-part transdiagnostic psychological intervention aimed to help people respond to negative emotion and emotional distress in more adaptive ways using a technology called "ecological momentary intervention" (or emi) that delivers intervention content using a smartphone app. participants in this study will be rutgers students recruited through-or currently affiliated with - counseling, alcohol and other drug assistance program \& psychiatric services (caps) at rutgers. participants will first attend either one-on-one or group telehealth therapy sessions/workshops, where they will learn the therapeutic skills that are part of the study. then, they will complete up to 8 weeks of smartphone monitoring that involves assessments and opportunities to practice the skills learned in therapy.


Eligibility criteria:
inclusion criteria * age 18 years or older * matriculated at rutgers during fall of 2020 (on campus and/or remote) * currently residing in us * willingness to follow study requirements, as evidenced by an ability to provide written informed consent and read, understand, and complete the study procedures * ios and android smartphone compatible with metricwire. nearly all phones since 2014 are compatible exclusion criteria * non-english speaking * unable to understand or provide informed consent
endoscopic gastric reduction of gastric mucosa in obesity

Conditions: Obesity, Morbid; Endoscopy

Summary: in the stomach, the ghrelin-containing cells are more abundant in the fundus than in the pylorus originally termed x/a-like cells. these x/a-like cells account for approximately 20 % of the endocrine cell population in adult oxyntic glands. ghrelin enhances the secretion of growth hormone, the stimulation of appetite and food intake, the modulation of gastric acid secretion \& motility and the endocrine and exocrine pancreatic secretions.

ghrelin is 28 amino acid peptide hormone, approximately 70 % of circulating ghrelin is secreted by the stomach, with most of the remainder originating in duodenum, jejunum, and ileum. lower amount of secretion outside the gut, including hypothalamus (arcuate nucleus and paraventricular nucleus), pituitary, lung, adrenal cortex, kidney, bone, testis, placenta and pancreatic islet cells ghrelin enhances the secretion of growth hormone, the stimulation of appetite and food intake, the modulation of gastric acid secretion \& motility and the endocrine and exocrine pancreatic secretions. synthetic ghrelin imitative was shown to increase fat deposition and appetite through an action at the level of the hypothalamus arcuate nucleus mainly the orexigenic neuropeptide y (npy) neurons. alterations of ghrelin play an important role in appetite fluctuation following meals. the secretion of ghrelin by the stomach depends largely on the nutritional state. ghrelin levels show pre-prandial increases and postprandial decreases. low systemic ghrelin levels have been reported in untreated hyperthyroidism, in male hypogonadism, in the polycystic ovary syndrome, or after total gastrectomy \[5, 6\].

Eligibility criteria:
inclusion criteria: * body mass index more than 25 * diagnosis of diabetes mellitus. * diagnosis of cardio-metabolic syndrome. * fatty liver disease diagnosed by abdominal ultrasound. exclusion criteria: * use of drugs which induce insulin resistance, diabetes and hepatic steatosis. * excess alcohol consumption. * chronic gastritis, active peptic ulcer. * malignancy. * depression and severe psychological disorders * inability to give informed consent. * coagulopathy (inr more than 1.5, platelets less than 50000 per cmm). * severe cardiopulmonary comorbidity.
study of new mutations in cone disorders

Conditions: Retinal Dystrophy, Cone-Rod; Cone Dystrophy; Cone Rod Dystrophy; Macular Degeneration

Summary: high throughput sequencing gives the opportunity to improve the genetic diagnosis for patients suffering from retinal dystrophies and specially from cone disorders. however, a large number of mutations are identified, mostly in introns of the genes, and in silico analysis are not sufficient to assign the pathogenicity of these mutations, without which the diagnosis confirmation cannot be done. for that purpose, a functional analysis of intronic variants of unknown significance detected in patients, with minigene splice assays in parallel with the analysis of the effect of the variant on splicing directly in the cells of the patient, by analyzing the rna from leucocytes, fibroblasts, lymphoblastoïd cells or precursor of photoreceptor cells, which is the only proof of pathogenicity for variants


Eligibility criteria:
inclusion criteria: * clinical diagnosis of cone disorder * identification of a variant of unknown significance * possibility of samplings * informed consent exclusion criteria: * no variant of unknown significance identified * no informed consent

Keywords: intronic variant splicing functional test cone disorders retinal dystrophy rna minigene splice assay cells
effects of preoperative rehabilitation in patients resected for lung cancer

Conditions: Lungcancer

Summary: this randomized controlled trial will evaluate the effect of a preoperative rehabilitation program at home in patients resected for lung cancer, comparing a control group (c group) receiving only chest physiotherapy and a rehabilitation group (r group) receiving both a training program at home and chest physiotherapy


Eligibility criteria:
inclusion criteria: * patients diagnosed for lung cancer (or highly suspicious for cancer tumor) eligible for resection surgery (lobectomy or pneumonectomy) * age \> 18 years * presence of chronic obstructive pulmonary disease (copd) stages 2-4 of gold (forced expiratory volume (fev )/ forced vital capacity (fvc) \ 1 * patients must provide written consent * member of social security scheme exclusion criteria: * patients refusing to participate * copd stage 1 gold (vems \>= 80% of the theoretical value) * presenting an operating contraindication during the initial maximal exercise test * presenting cardiac or vascular contraindication to achieve the readaptation program * patient living alone at home * patient with ventilatory assistance at home (oxygen therapy or noninvasive ventilation (niv)) * with exercise hypoventilation (paco2 \>45 mmhg) * cognitive difficulty * unable major * pregnancy, * patients deprived of liberty by a court or administrative decision

Keywords: preoperative rehabilitation program chest physiotherapy lung cancer resection
pilot study for the urinary incontinence treatment

Conditions: Urinary Incontinence

Summary: non invasive study to improve the urinary incontinence, through pelvic floor muscles exercises

a non invasive study to improve the urinary incontinence performed in 36 women from two groups: 18 menopausal women and 18 fertile women. the participants have to do pelvic floor muscles exercises with a restorative pelvic floor device every day for two months using the magic kegel app download in their mobile devices

Eligibility criteria:
inclusion criteria: * urinary incontinence diagnosis exclusion criteria: * no urinary infection * no surgery for urinary incontinence

Keywords: urinary incontinence pelvic floor
unimalleolar versus bimalleolar fixation in bi- or trimalleolar ankle fracture

Conditions: Trauma

Summary: a one third of all ankle fractures are bi- or trimalleolar. traditionally these fractures are treated by both medial and lateral osteosynthesis, sometimes accompanied by osteosynthesis of the posterior malleolus. there is significant evidence that fractures of the lateral malleolus can be treated conservatively if the medial side is stable. however, there isn't a single study comparing standard bi- or trimalleolar fixation with only medial side osteosynthesis and postoperative immobilization with a cast.


Eligibility criteria:
inclusion criteria: * weber b bi- or trimalleolar ankle fracture (fracture of the lateral and medial malleolus +/- posterior malleolus sized under 30% of the distal tibia joint line measured from the lateral projection of the standard ankle radiographs) * age: 16 years or older * voluntary * operated within 7 days of the trauma * able to walk unaided before the current trauma exclusion criteria: * peripheral neuropathy * pilon fracture * bilateral ankle fracture * concomitant tibial fracture * pathological fracture * active infection around the ankle * a previous ankle fracture on either side * in trimalleolar fractures, posterior malleolus fracture sized over 30% of the distal tibia joint line measured from the lateral projection of the standard ankle radiographs * inadequate co-operation * permanent residence outside the catchment area of the study hospital

Keywords: ankle fracture medial malleolus osteosynthesis
rt-fmri nf intervention study in asd

Conditions: Autism Spectrum Disorder

Summary: this study aims to demonstrate that fmri neurofeedback training improves the identification and comprehension of emotional facial expressions (and overall social behaviour) in subjects with asd. the intervention setup provides structured presentation of emotional facial expressions and the associated tools for mental imagery. the investigators hypothesize that the accomplishment of the proposed competence training improves the subjects ability to comprehend facial expressions, identify emotions and be able to correctly express them. intervention type is a device (brain computer interface using brain imaging signals) and the specific intervention name is neurofeedback. structure: (1) initial eligibility screening, (2) pre-intervention (first week of study, baseline outcome measures and additional evaluations), (3) intervention process (8 weeks), (4) post-intervention (outcome measures and additional evaluations), and (5) follow-up (outcome measures at 6 months).

clinical research has demonstrated that asd children have deficits in the identification and interpretation of the emotional and mental state of others (baron-cohen 2001). an important skill to this end (impaired in asd patients), is to appropriately recognize and discriminate emotional expressions. the main brain regions involved in face processing the inferior occipital gyri, lateral portion of the fusiform gyrus (especially a region deemed the fusiform face area or ffa), and posterior superior temporal sulcus (psts) (haxby et al. 2000). sts plays a key role on several basic aspects in social information processing, and deficits in asd have been found associated to this region. the purpose of the study is to determine the effect of neurofeedback considering a social cognition brain region (i.e. psts) on the identification of facial expressions in asd patients. the intervention comprehends seven bci sessions spread over four months. the first four sessions are weekly, and the rest monthly. in each session, the subjects are asked to imagine different facial expressions and their brain activity (i.e. bold activation in the psts region) is interpreted and used to estimate a feedback signal.the hypothesis is that the training induced up-regulation of the target region, improves clinical symptoms.

Eligibility criteria:
inclusion criteria: * positive diagnostic results for asd in: autism diagnostic interview-revised; autism diagnostic observation schedule; the diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) criteria. exclusion criteria: * global intelligence quotient \< 80 * associated medical condition such as epilepsy, neurocutaneous or other genetic syndromes, or other usual comorbidity in asd samples
ripc and platelet activation on platelet activation during cardiopulmonary bypass

Conditions: Platelet Dysfunction

Summary: in this study, the investigators are going to investigate the effects of remote ischemic preconditioning on platelet activation in patients undergoing cardiac surgery with cardiopulmonary bypass.

previous studies reported that remote ischemic conditioning reduce platelet activation in patients with coronary artery disease or patients undergoing ablation for atrial fibrillation. cardiac surgery with cardiopulmonary bypass has been associated with platelet activation. in this randomized study, investigators are going to compare the effects of remote ischemic preconditioning (ripc) on platelet activation using flow cytometry in patients undergoing cardiac surgery with cardiopulmonary bypass.

Eligibility criteria:
inclusion criteria: * patients undergoing cardiac surgery with cardiopulmonary bypass exclusion criteria: * preoperative left ventricle ejection fraction \< 30%, mechanical ventricular support * peripheral vascular disease * poorly controlled diabetes mellitus * nsaids within 3 days * iv heparin within 6 h * low molecular weight heparin within 24 h * platelet inhibitor within 24 h * known thrombocytopenia * end stage renal disease / hemodialysis * active infection * pregnancy

Keywords: platelet activation remote ischemic preconditioning