Kornimate/medical-research-clean huggingface dataset:
effects of pulmonary rehabilitation in salt chambers on functional efficiency, respiratory parameters, and blood rheology in elderly with respiratory diseases.

Conditions: the Elderly; Respiratory Disorders

Summary: the aim of the study is to assess the impact of the rehabilitation and treatment stay at the underground health resort of the 'wieliczka' salt mine in wieliczka on the functional capacity, respiratory parameters, and rheological properties of blood in elderly individuals with respiratory diseases.

the research project will involve patients aged 65 and older with chronic respiratory diseases. based on controlled studies conducted at the health resort "wieliczka" salt mine in wieliczka, and assuming the project will be a prospective, experimental, controlled study with a crossover design, calculations were made for the primary variable under investigation (exercise tolerance). these calculations determined that 29 pairs of participants are needed to achieve a statistical power of 80% and a significance level of 5% (bilateral). to detect a mean difference between pairs of 58, assuming a standard deviation of 106 for these differences and accounting for a 10% loss of participants from observation, the required sample size was increased to 33 pairs. given the crossover design, the study plans to include 33 patients. volunteers will undergo qualifying tests, measurements of functional fitness, respiratory indicators, and blood rheology tests 3 weeks prior to the start of the rehabilitation and therapeutic stay in the underground salt chambers (1st test). during the 3-week period before the rehabilitation, participants will not engage in any other form of therapeutic rehabilitation. functional fitness, respiratory indicators, and blood rheology tests will be repeated before the start of the stay (2nd test), immediately after its completion (3rd test), and 3 months after its completion (4th follow-up test). each day of the rehabilitation and therapeutic stay will include a 2.5-hour visit to the underground health resort under the supervision of a doctor, physiotherapist, and nurse, during which pulmonary rehabilitation will be implemented.

Eligibility criteria:
inclusion criteria: * people aged 65 and older with chronic respiratory diseases in a stable period of the disease (without exacerbations), qualified to participate in a rehabilitation and treatment stay in the underground health resort 'wieliczka' salt mine in wieliczka, * patients who gave informed, written consent to participate in the study. exclusion criteria: * patients with contraindications to subterraneotherapy and physical exercise, * lack of written consent to participate in the study, * deterioration of health during the implementation of the program.

Keywords: pulmonary function, speleotherapy, blood tests, 6mwt, chest
genetic & pathological studies of brca1/brca2: associated tumors & blood samples

Conditions: Breast Cancer; Ovarian Cancer; Gynecologic Cancers; Ovarian/Peritoneal/Fallopian Cancer

Summary: the purpose of this study is to try to understand the biology of development of breast, ovarian, fallopian tube, peritoneal or endometrial cancer from persons at high genetic risk for these diseases. the influence of environmental factors on cancer development in individuals and families will be studied. the efficacy of treatments for these diseases will be evaluated.

1. to establish a demographic database to evaluate the efficacy of medical interventions in patients and relatives who carry brca1 and 2 mutations and to compare these outcomes to patients who do not carry a brca1 or 2 mutation. 2. to obtain blood samples from patients who undergo genetic testing to a) evaluate the incidence of genetic modifier polymorphisms involved in the development of cancer in brca1 and 2 mutation carriers and to compare this incidence to non-brca 1 and 2 carriers. b) to understand the interaction of genetic modifiers and brca1 and 2 in the development of cancer. c) to determine the effect of environmental influences on the incidence of polymorphisms in genetic modifiers and on the penetrance of brca1 and 2 mutations by linking information from our demographic database to blood samples and 3. to obtain tumor tissue from brca1 and 2 carriers to utilize for gene expression studies. 4. to establish a cohort of sporadic breast cancer patients, or women with no family history of cancer in a first degree relative, to serve as a comparison group to women with strong family history of breast cancer. 5. to establish a cohort of healthy volunteers without personal or family history of cancer to serve as a comparison group to women with sporadic and familial breast cancer.

Eligibility criteria:
inclusion criteria: i. women who have a high risk of developing breast or ovarian cancer due to a known germline mutation in the brca1/2, pten, cdh1, or tp53 cancer susceptibility genes, or due to strong family history of either breast or ovarian cancer, in the absence of known cancer susceptibility gene mutation. ii. women who are approaching surgery for resection of a pelvic mass, which is considered suspicious for neoplasia by radiologic or clinical criteria; such women may or may not also meet criteria for inclusion in group i.

Keywords: quality of life
inspiratory muscle training versus calf muscle on venous function

Conditions: Venous Insufficiency

Summary: the aim of this study was to evaluate the effect of exercise training in addition to compression therapy on quality of life, venous return time, muscle strength, clinical severity, functional capacity in venous insufficiency compared to compression treatment alone. fourty-two volunteer patients with venous insufficiency will include in the study were randomly divided into three groups as inspiratory exercise, calf muscle exercise and control. while the control group will receive only compression therapy, the inspiratory exercise group will apply inspiratory muscle training consisted of strengthening exercise in addition to compression therapy; kalf muscle exercise group will apply strengthening exercise for calf muscle in addition to compression therapy for 2 days/week with physiotherapist and 3 days/week by themselves, 8 weeks. all the patients will assess with chronic venous disease quality of life questionnaire-20 (civiq-20), nottingham health profile, photopletismograph, venous clinical severity score (vcss), hand-held dynamometer, visual analogue scale (vas), circumference measurements, 6-minute walk test (6mwt), before and after the treatment.


Eligibility criteria:
inclusion criteria: * diagnosis of venous insufficiency between 18-75 years with duplex ultrasound imaging * ceap classification used in venous insufficiency is c2-c3-c4-c5 * having written and verbal communication in turkish exclusion criteria: * acute deep vein thrombosis * the presence of ulceration * being in class iii and iv according to the new york heart association classification * presence of respiratory failure * undergoing chemotherapy due to the presence of any cancer * being in the process of treatment for neurological, orthopedic or rheumatologic diseases including lower extremity

Keywords: venous insufficiency exercise therapy inspiratory muscle kalf muscle venous return
clinical performance of bulk fill composite with activa bioactive liner

Conditions: Clinical Study of Activa Bioactive Restorative; Dental Caries

Summary: electromyographic activity as well as clinical performance of bulk-fill composite resins with activa bioactive liner


Eligibility criteria:
inclusion criteria: * patients between the ages of 18-40 years and cooperative patient. * good oral hygiene. * normal occlusal relation with normal dentition. exclusion criteria: * patient with severe medical problems. * tenderness with percussion or pre-operative pulpal pain. * mobile tooth and tooth with gingival recession. * pregnant or lactating females. * cracked teeth or teeth with deep periodontal pockets. * tooth with previous restoration. * allergy to resin materials. * defective restorations adjacent or opposing to tooth. * patient with bruxism
trial to evaluate the effects of sound modulation on critically ill patients

Conditions: Critical Illness; Physiological Stress; Delirium; Sleep Deprivation

Summary: the goal of the project is to determine the effects of noise masking and noise reduction on stress related physiological parameters in critically ill patients admitted to the intensive care unit.

sleep deprivation is common in critically ill patients in the intensive care unit (icu) and may impair recovery. while noise is widely cited as the most common cause of sleep disruption in the icu setting, its contribution to sympathetic activity in critically ill patients is not known. this is an important knowledge gap, because noise initiates a sequence of physiological changes including vasoconstriction, raised diastolic blood pressure, pupil dilatation and muscle tension. furthermore, noise is implicated in sympathetic arousals, resulting in a release of adrenaline which prevents relaxation and consequently prevents the patient from falling asleep. the investigators plan to study the effect of noise masking and noise reduction on stress related physiological parameters in critically ill patients admitted to the icu. subjects will be randomized into 3 separate groups: control, noise reduction, and noise masking. the investigators will compare the heart rate and blood pressure variability between and within the groups to determine the effects of treatment assignment on these variables. non-invasive measurements obtained from the bedside monitor will be collected using physiological data acquisition software.

Eligibility criteria:
inclusion criteria: * subjects aged 18-99 years who are expected to receive care on an adult critical care unit for at least 24 hours exclusion criteria: * admission for drug overdose or with a known substance abuse disorder * untreated sleep apnea disorder, narcolepsy, rem sleep behavior disorder, parasomnia, restless leg syndrome or other sleep disorder * use of hearing aids, or known significant conductive or sensory hearing loss * ventilator support via an endotracheal tube * use of vasopressors * unresponsive or delirious * subjects with known dementia, parkinson's disease, or other neurodegenerative disorder * subjects with a pacemaker or who have received cardiac transplant

Keywords: heart rate blood pressure variability
spine fa3 - a prospective, international, multicenter cohort study on treatment of of ao a3 thoracolumbar fractures

Conditions: Single Level Stable Thoracolumbar Fracture Type AO A3; Multiple Level Stable Thoracolumbar Fracture Type AO A3

Summary: thoracolumbar fractures are the most common spinal fractures with an average annual incidence between 18 and 30 per 100'000 inhabitants. the majority of these fractures are ao type a3 ("burst fractures"). although patients with burst fractures report a reduced quality of life and chronic pain, there is no clear evidence whether surgical or conservative treatment offer better functional and back-pain related outcomes. the indications for the selection of an ideal treatment for these fractures without neurological deficits remain controversial. the purpose of this study is to evaluate whether patients with thoracolumbar fractures without neurological deficit being surgically treated show faster recovery and better improvement of function than patients being conservatively treated.


Eligibility criteria:
inclusion criteria: * age 18-65 years * diagnosis of single or multiple stable thoracolumbar fracture(s) * level t10- l3 * type ao a3 or a4 * radiologically confirmed by rx or ct * fracture induced kyphotic deformity lower or equal to 20-35 degrees * definitive treatment (surgical or conservative) within 10 days after injury * american spinal injury association (asia) impairment scale = e (normal ) * ability to understand patient information / informed consent form * willingness and ability to participate in the clinical investigation including imaging and follow-up procedures (fus) * signed informed consent exclusion criteria: * open fracture * polytrauma * pathologic fracture * disruption of the posterior ligamentous complex between t10 and l3 * clinically evident osteoporosis as assessed by the investigator * spinal luxation * associated severe lesions as assessed by the investigator * spinal lesion due to gun or projectile * pre-existing spinal column deformity * prior spinal surgeries * bmi \> 40 kg/m2 * any severe medically not managed systemic disease * recent history of substance abuse (ie, recreational drugs, alcohol) that would preclude reli-able assessment * pregnancy or women planning to conceive within the study period * prisoner * participation in any other medical device or medicinal product study within the previous month that could influence the results of the present study

Keywords: burst fractures thoracic or lumbar vertebrae/injuries [mesh] thoracic or lumbar vertebrae/surgery [mesh] spinal fusion/methods [mesh] thoracolumbar fracture management quality of life functional outcome
the effect of video-assisted mobilisation training on mobility, anxiety and pain after coronary artery bypass surgery

Conditions: Anxiety; Postoperative Pain

Summary: this study is a randomized controlled trial.the aim of this study was to investigate the effect of preoperative routine patient education and video-assisted mobilization training on postoperative mobility, anxiety level and pain in patients undergoing coronary artery bypass graft surgery. hypotheses of the study: h1= routine patient education and video-assisted mobilization training have an effect on postoperative anxiety level in patients undergoing coronary artery bypass graft surgery. h2= routine patient education and video-assisted mobilization training have an effect on postoperative mobility in patients undergoing coronary artery bypass graft surgery. h3= routine patient education and video-assisted mobilization training have an effect on postoperative pain in patients undergoing coronary artery bypass graft surgery.

this study is a randomized controlled trial. the study consists of 80 patients, 40 control and 40 study group. patients in the experimental group who underwent coronary artery bypass graft surgery completed the "state trait anxiety scale" in the preoperative period. then, video-assisted mobilization training was given together with routine patient training.after the patient underwent surgery, the "state trait anxiety scale" was completed again before the first mobilization.after the first mobilization, "patient mobility scale" and "observer mobility scale" were completed."state trait anxiety scale" was used again on the 2nd postoperative day before mobilization."patient mobility scale" and "observer mobility scale" were used after the patient was mobilized. patients in the control group who underwent coronary artery bypass graft surgery completed the "state trait anxiety scale" in the preoperative period.routine patient education was then given.after the patient underwent surgery, the "state trait anxiety scale" was completed again before the first mobilization.after the first mobilization, "patient mobility scale" and "observer mobility scale" were completed. the "state trait anxiety scale" was used again before mobilization on the 2nd postoperative day.after the patient was mobilized, "patient mobility scale" and "observer mobility scale" were used.

Eligibility criteria:
inclusion criteria: * patients undergoing coronary artery bypass graft surgery, * patients aged 18 years and older, * patients who can speak turkish, * patients without a diagnosis of cognitive and psychiatric disorders that prevent them from expressing themselves, * patients open to communication, * patients who volunteered to participate in the study and gave verbal and written informed consent. exclusion criteria: -

Keywords: coronary artery bypass graft pain mobility anxiety
a practical model to transform childhood asthma care - spirometry training in the primary care setting

Conditions: Asthma

Summary: spirometry is a recommended component of asthma diagnosis and treatment in the primary care setting, however, few primary care providers report routine use of spirometry in the provision of care for their asthma patients. even when spirometry is used to aid in asthma severity classification, primary care providers have a high rate of failing to meet the quality goals for testing established by the american thoracic society. the goal of this study is to evaluate the effectiveness of a virtually delivered quality improvement (qi) program. the program is designed to train primary care providers and their medical staff in the use of spirometry to improve pediatric primary care management for children with asthma.

a cluster randomized trial with matched practice pairs. all practices receive a spirometer and standard vendor training. those randomized to the intervention group receive a 7-month qi program, which includes: 1. spirometry fundamentals™ cd-rom; 2. case-based, interactive webinars; and 3. an internet-based spirometry quality feedback reporting system.

Eligibility criteria:
inclusion criteria: * internet access on a computer running windows xp sp2 * access to a computer with windows 2000 /mac os 10 or higher * practices must match another enrolled practice on the following parameters. 1. number of providers in practice (same number +/- 1 provider) 2. location - both practices must either be urban or rural 3. % of patients eligible for medicaid (same percentage +/- 15%) 4. practice type (school-based clinic, federally qualified health center, private practice, hospital- or university-based clinic) 5. geographic distance (minimum of 10 miles away from matched pair practice) exclusion criteria: * lack of internet access on a computer running windows xp sp2 * lack of access to a computer with windows 2000 /mac os 10 or higher * practices that were unable to be matched to another similar practice

Keywords: asthma spirometry pediatric primary health care education, distance
characterizing clinical and biomechanical contributions to function following acl reconstruction

Conditions: ACL Tears

Summary: quantify differences in quadriceps function and gait biomechanics in individuals within 2 years of acl reconstruction compared to a healthy comparison group and establish the feasibility of conducting a progressive strengthening program to improve clinical and patient-oriented outcomes in individuals who are within 2 years of acl reconstruction

a maximal isometric muscle contraction of the quadriceps will be used to examine neural and peripheral contributions to quadriceps strength. neural influences will be quantified using the interpolated twitch technique (voluntary activation) and early rtd. peripheral influences will be quantified by examining the stimulus-evoked torque with the quadriceps relaxed (resting twitch) and late rtd. knee joint biomechanics during treadmill walking and running will include sagittal plane (flexion, extension) movement variability (lyapunov exponent and approximate entropy), peak knee flexion angle, and peak external knee flexion and adduction moments. additionally, the clinical relevance of impairments in the acl reconstruction group will be determined by examining the relationship with performance on jumping tasks and patient function (secondary outcomes). the progressive strengthening program will be performed for 6 weeks and emphasize development of strength and power. feasibility will be established if the researchers can recruit up to 8 participants and retain at least 80% over the 3 week intervention program. the researchers will determine effect sizes for changes outcome measures.

Eligibility criteria:
inclusion criteria: * physically active * history of primary unilateral acl reconstruction within the past 3-24 months (acl group only) exclusion criteria: * history of lumbar spine or lower extremity injury or surgery (except acl) within the past 1 year that required physician care * concomitant knee injury (acl group only): ligament injury that requires surgical repair (medial collateral ligament \[mcl\], posterior cruciate ligament\[pcl\]), chondral defects \>2cm, fracture, bilateral knee injury * medial conditions that are contraindications to electrical stimulation: cardiac pacemaker and pregnancy * participants who are unable to understand procedures of experiment or provide consent (assent/parental permission)

Keywords: quadriceps strength quadriceps voluntary activation progressive strength program
dietary monosaccharide supplementation in patients with congenital disorders of glycosylation

Conditions: Congenital Disorder of Glycosylation

Summary: researchers are trying to assess whether the use of simple sugars given as a daily dietary supplement can improve the health of children with congenital disorders of glycosylation (cdg).

the goal of this study is to collect data from patients diagnosed with congenital disorders of glycosylation and taking a simple sugar supplement. the study team wants to expand the evidence on the beneficial effects of this treatment in clinical practice.

Eligibility criteria:
inclusion criteria: * patient has a biochemically and genetically proven congenital disorder of glycosylation * patient is receiving (or planning to receive) oral simple sugar supplementation exclusion criteria: * aldolase b deficiency * galactosemia * hemolytic uremic syndrome * severe anemia * galactose intolerance
circulating transforming growth factor beta (tgf-β) in individuals with marfan syndrome

Conditions: Marfan Syndrome

Summary: transforming growth factor beta (tgf-β) is a protein that controls proliferation, cellular differentiation, and other functions in most cells. tgf-β levels play a major role in the pathogenesis of marfan syndrome, a disease characterized by disproportionate height, long extremities, lens dislocation in the eyes and heart complications such as mitral valve prolapse and aortic enlargement increasing the likelihood of aortic dissection. while the underlying defect in marfan syndrome is faulty synthesis of the glycoprotein fibrillin i, normally an important component of elastic fibers it has been shown that the marfan syndrome phenotype can be relieved by addition of a tgf-β antagonist in affected mice.

transforming growth factor beta (tgf-β) is a protein that controls proliferation, cellular differentiation, and other functions in most cells. tgf-β levels play a major role in the pathogenesis of marfan syndrome, a disease characterized by disproportionate height, long extremities, lens dislocation in the eyes and heart complications such as mitral valve prolapse and aortic enlargement increasing the likelihood of aortic dissection. while the underlying defect in marfan syndrome is faulty synthesis of the glycoprotein fibrillin i, normally an important component of elastic fibers it has been shown that the marfan syndrome phenotype can be relieved by addition of a tgf-β antagonist in affected mice. this suggest that while the symptoms of marfan syndrome may seem consistent with a connective tissue disorder, the mechanism is more likely related to reduced sequestration of tgf-β by fibrillin.

Eligibility criteria:
inclusion criteria: * individual with marfan syndrome consented in to the main atenolol vs. losartan nih study. exclusion criteria: * subjects in the main phn marfan trial who have not achieved the maintenance drug dosing or who have stopped taking study drug.

Keywords: tgf-b blood levels atenolol vs, losartan study, nih, nihlb and nmf