Kornimate/medical-research-clean huggingface dataset:
contingency management for hoarding disorder

Conditions: Hoarding Disorder

Summary: aim 1: to test the efficacy of contingency management for patients with hoarding disorder (hd). hypothesis 1. participants completing cm will show significant pre- to post-treatment decreases in severity of hoarding symptoms and clinician-rated impairment, and significant increases in quality of life. exploratory analyses will examine whether effect sizes compare with those of prior trials of cognitive-behavioral therapy (cbt) for hd conducted within our clinic, whether problem severity at follow-up is predicted by hoarding severity measured immediately after treatment completion, and whether readiness for change improves with treatment.

the primary aim of the current study is a preliminary investigation of the efficacy of contingency management (cm) in the treatment of hoarding disorder (hd). cm is a highly efficacious treatment that has been used to treat issues such as substance use disorders, medication/ medical regimen nonadherence, and schizophrenia. while the current best-practice treatment for hd (cognitive behavioral therapy; cbt) is efficacious in that it results in significant symptom reduction, many patients continue to have high levels of functional impairment and distressing symptoms after treatment completion. we strongly feel that cm is able to address many of the issues that arise in the context of cbt for hoarding and we feel that the addition of cm to as cbt will result in significant pre- to post-treatment decreases in severity of hoarding symptoms and impairment, and significant increases in quality of life.

Eligibility criteria:
inclusion criteria: * diagnosed with primary hoarding disorder, * currently participating in the hoarding disorder treatment group at the hh anxiety disorders center exclusion criteria: * not clinically appropriate for a group treatment format (i.e., active suicidality or aggressive behavior, psychosis, current physiological substance dependence, or personality issues that would be expected to substantially interfere with the group milieu; cognitively intact). * participants will also be excluded if they have previously completed cbt for hd. * in addition, participants in the cm portion of the treatment will be required to live within one hour travel time of the treatment facility to allow for home visits with the independent rater.

Keywords: hoarding disorder contingency management cognitive-behavioral therapy group therapy
measuring choroidal thickness using optical coherence tomography

Conditions: Choroid Disease; Diabetes Mellitus

Summary: to compare the choroidal thickness in eyes of diabetic patients with eyes of age matched controls using optical coherence tomography.

diabetic retinopathy (dr) is the most common and specific complication of dm. it is one of the leading causes of preventable blindness in the adult working population. (1) dr was the fifth leading cause of blindness and of moderate and severe vision impairment. global prevalence of diabetic retinopathy was 22.27% and prevalence was highest in africa (35.90%). (1) fortunately, much of the visual loss from dr is preventable, and the rates of vision loss from diabetes and dr have declined over the past few decades due to advances in ocular disease assessment, screening, imaging and treatment in recent years. (2) the outer third of the retina gets oxygen and nutrients from choroid. the three vascular layers of choroid are chorio capillaries layer, sattler layer and haller layer. (3) a healthy choroid is essential for retinal function by continuous perfusion into the outer retina, which plays critical roles in thermoregulation of the retina, maintenance of the anatomic position of the retina, removal of residues, and secretion of growth factors. (4-5) the vascular choroid changes of the diabetic patients are quite similar to those seen in dr, such as increased vascular tortuosity, vascular outpouchings, microaneurysms, nonperfusion areas, vascular dilations and narrowing, and choroidal neovascularization. (6) until recently, the choroid could only be evaluated by indocyanine green angiography, laser doppler flowmetry, and ultrasonography. (6) optical coherence tomography (oct) is a non-invasive imaging modality, which is used in acquiring high-resolution sections of retina. (5)

Eligibility criteria:
inclusion criteria: * all known type 2 dm patients aged 30 to 95 years either gender who presented to ophthalmology clinics in assuit ophthalmology hospital with no history of ocular treatment (ocular treatment naïve) and visual acuity of 0.1 (6/60) or more that are able to complete an eye examination, and non-diabetic healthy individuals (hba1c \<7) will be included in the study. exclusion criteria: * known diagnosis of any other retinal disease, glaucoma, neurodegenerative disease, and any significant media opacities that precluded fundus imaging and not giving consent will be excluded.
a study of the zanubrutinib given in combination with bendamustine and rituximab in (elderly or tp53 alterations or chemotherapy intolerance) patients with newly diagnosed mantle cell lymphoma

Conditions: Lymphoma, Mantle-Cell

Summary: the purpose of this study is to evaluate the efficacy and safety of zanubrutinib given in combination with bendamustine and rituximab in (elderly or tp53 alterations or chemotherapy intolerance) patients with newly diagnosed mantle cell lymphoma.


Eligibility criteria:
inclusion criteria: * 18 years * histopathologically confirmed mantle cell lymphoma according to the 5th edition of the world health organization (who) * fish with del(17p)/tp53 mutation or ≥65 years; or\<65 years but chemotherapy intolerance; * life expectancy of \> 3 months (in the opinion of the investigator); * creatinine clearance rate (ccr) ≥ 50 ml/min or estimated glomerular filtration ●rate (egfr) ≥ 60 ml/(min·1.73 m\^2); * international normalized ratio (inr) ≤ 1.5 and activated partial thromboplastin time (aptt) ≤ 1.5 times the upper limit of normal; * left ventricular ejection fraction (lvef) ≥ 50%; * agreeing to provide written informed consent prior to any special examination or procedure for the research on their own or legal representative. exclusion criteria: * pregnant or lactating women; * known hepatitis b virus (hbv) and/or hepatitis c virus (hcv) infection (hbv infection refers to hbv-dna \> detectable limit); * with acquired or congenital immunodeficiency; * with congestive heart failure in 6 months before enrollment, new york heart association (nyha) heart function class iii or iv, or lvef \< 50%; * known to be allergic to the test drug ingredients; * diagnosed with or being treated for malignancy other than lymphoma; * with severe infection; * substance abuse, medical, psychological, or social conditions that may interfere with the subjects' participation in the study or evaluation of the study results; * deemed unsuitable for the group.
vascular access decision aid

Conditions: Coronary Artery Disease; Atherosclerosis

Summary: coronary angiogram (ca) procedures, with and without angioplasty, can be performed via vascular access in the wrist (radial artery) or leg (femoral artery). both radial and femoral artery vascular access have their advantages and disadvantages, but neither has yet been proven to have superior health outcomes. often patients are eligible for both access sites but are not well informed regarding the potential advantages and disadvantages of each site. vascular access in cardiac catheterization can be considered a "grey zone", where the benefits and harms may have different levels of significance depending on the individual's preferences and values. for example, patients with significant back pain may not prefer the femoral approach as it requires the patient to lie flay for an extended period of time compared to the radial approach. for "grey zone" health care options, patient decision aids (ptda) have been demonstrated to improve the quality of decision making by significantly improving knowledge of the patient's health care options, improving the patient's accurate risk perception, and improving value congruence with the chosen options. the investigators propose a randomized controlled trial (rct) to evaluate the decision quality impact of a vascular access ptda compared to "usual care" in eligible patient's undergoing elective ca procedures. if the ptda is demonstrated to positively impact the decision quality of patients prior to ca procedures, it would be an invaluable bedside tool to promote patient informed medical decision making. hypothesis: the investigators believe that a ptda, when compared to usual care, will positively impact the decision quality and the process of decision making, relating to vascular access options in eligible patients undergoing elective ca procedures.


Eligibility criteria:
inclusion criteria: * age \> 18 years old * english speaking * able to provide informed consent * is able to read the english language (however, if a patient is not able to read due to visual impairment, they may still be considered for enrollment if a family member is present to read and relay the content of the ptda) * candidates for both femoral and radial access as defined by the pre-assessment checklist and subsequently approved by their treating physician exclusion criteria: * any patients not meeting the inclusion criteria * the interventional cardiologist performing the procedure does not feel comfortable or believes the patient is ineligible for either access (may include reason's not specifically outlined in the pre-assessment checklist)

Keywords: coronary angiogram decision aid vascular access radial femoral
anatomic relationship of the popliteal vessels in open wedge osteotomy

Conditions: Knee Osteoarthritis

Summary: the aim is to study the anatomic relationship of the popliteal vesseles in two types of (owhto) techniques (monoplanar vs biplanar) which provide more safe technique to the pv

open wedge high tibial osteotomy (owhto) is a common surgical procedure that is utilized to correct knee varus deformity and prevent development or advancement of medial compatment knee osteoarthritis. by turning the mechanical weight-bearing axis to the lateral side it correct lower limb alignment,decrease medial compartment load,pain,arthritic changes, postpone the need for arthroplasty and allow cartilage regeneration. like any other surgical procedure (owhto) has its own complications.injury to the popliteal vessels (pv) is catastrophic and limb threatening compliation that had been reported with prevalence rate ranging from 0.4% to 1.7% pv runs close to the posterior tibial cortex it might be injured while taking osteotomy cut. to avoid this problem many studies with different tools done to define pv position and its relations to provide safe technique for osteotomy. (owhto) has different methods: monoplanar and biplanar osteotomy are most popular,both techniques differ in cut level and shape. in this study the investigators compare between the two methods (monoplanar vs biplanar) concerning their proximity and safety to the pv . our hypothesis is that there is increase in the distance between the pv and the posterior tibial cortex the more distal the osteotomy level. previous studies cadaveric or preoperative studies provide useful informations with some different results , to the best of our knowledge postoperative studies rarely reported in this subject , the investigators hope this study could provide valuable informations,recommend safer technique and improve surgical outcomes from this procedure.

Eligibility criteria:
inclusion criteria: * age 30-60 * bmi less than 30 * isolated medial compartment oa * mild to moderate degree oa grade 2 to 3 according to kellgren\&lawrence classification * near normal lateral and patellofemoral compartment * intact lateral meniscus * varus malalignment less than 15 degree * functional range of motion exclusion criteria: * inflammatory arthritis * post traumatic arthritis * patients with previous peripheral arterial injury * disease or prior insertion of metallic stent in the pv * patient allergic to contrast agent * patient with renal impairement * patients who refuse to participate in the study * patients who are not available for follow up
transdiagnostic group intervention for children with behavior problems

Conditions: Behavioral Symptoms; Emotional Disturbances

Summary: this study fills a notable gap in the transdiagnostic literature by evaluating whether an evidence-based transdiagnostic treatment for emotional disorders such as the unified protocol for children (up-c) is effective for treating childhood behavior problems.

by participating in the study, child participants will learn emotion regulation skills and have opportunities to interact and practice skills with other children who have similar problems. in addition, parent participants will learn effective parenting skills, including appropriate limit-setting, use of praise and consequences, and empathy, that may help them effectively navigate the challenges of caring for a child with behavior concerns (1). parents will also have the opportunity to interact with other parents who face similar challenges, providing validation and support. upon completion of the study, investigators plan to share these findings at professional conferences and submit manuscripts to peer-reviewed journals. collectively, this study will add to the literature in the pediatric mental health field and may also serve as a model for other outpatient clinics regarding implementation and provision of a transdiagnostic approach to treat children with behavior problems. thus, the main goals of the current study are to examine the effectiveness of the up-c group treatment in reducing childhood behavior problems, evaluate parents' satisfaction with this treatment, and determine the feasibility of implementing this treatment in a pediatric outpatient setting.

Eligibility criteria:
inclusion criteria: * ages 8 - 12 years * english speaking * primary behavior disorder * at least 1 english-speaking parent/legal guardian who can provide informed consent for the child * parent/legal guardian must agree to participate in the trial exclusion criteria: * child is: a ward of the state * has active suicidal ideation * has homicidal ideation * has self-harm behaviors * has an intellectual disability * has a pervasive developmental disability or significant developmental delay * has an active substance use disorder * is currently participating in individual or group psychotherapy, or * has participated in therapy within the past year * has a sibling that is also enrolled in the study * parents/legal guardians that: 1. are unwilling to participate in the study 2. are non-english speaking 3. have an intellectual disability 4. have a pervasive developmental disability or 5. a significant developmental delay 6. do not have legal custody of the child participant 7. do not reside in the same home as the child participant
portal vein thrombosis associated with unresectable pancreatic cancers : a prospective multicentric cohort study

Conditions: Pancreatic Adenocarcinoma

Summary: little is known concerning the management of portal vein thrombosis (pvt) in digestive cancers other than hepato-cellular carcinoma (hcc). the use of anticoagulant treatment (act), screening of oesophageal varices (ov) and oesogatric varices (ogv), and primary prophylaxis of ov (treatment with beta-blocker (bb) and / or ov ligation) if necessary are not clearly defined. the autopsy series by ogren et al. (world j gastroenterol. 2006) found an incidence of pvt in cancer patients of 1%, with 44% of digestive cancers other than hcc as a common etiology, mostly pancreatic adenocarcinoma (42%). we reported a retrospective french study that included 118 patients with digestive cancers other than hcc, including 50% locally advanced or metastatic pancreatic adenocarcinoma, with pvt complications. a total of 38% of patients had radiological signs of portal hypertension (pht) and 51% had act. only 1% of patients were screened for vo (n = 7). in addition, 19% (n = 22) presented gastrointestinal bleeding. among the causes of death, 17% (n = 12) were due to gastrointestinal bleeding. overall survival (os) was statistically associated with a metastatic disease (hr = 2.83 \[95% ci 1.47-5.43\], p \<0.01) and gastrointestinal bleeding (hr = 1.68 \[95% ci 1.01-2.78\], p = 0.04). bleeding complications from pht are not uncommon in patients with digestive cancer, especially in patients with pancreatic cancer with pvt; but above all they can be responsible for death. no data existed before our first study (regnault et al. dig liv dis 2018). however, these data must be validated in a prospective multicentric study with standardized follow-up. in order to obtain precise and homogeneous data, we have chosen to target pancreatic cancers as these tumors are the most common causes of pvt.


Eligibility criteria:
inclusion criteria: * pancreatic adenocarcinoma proven histologically or cytologically in favor of pancreatic adenocarcinoma * mesurable disease according to recist 1.1 criteria or non measurable disease * metastatic disease (synchronous or metachronous) or locally advanced / borderline deemed unresectable and / or patient inoperable due to his co-morbidities and / or local recurrence after surgery * thrombosis of the main portal vein and/or of one of its branches (endo-luminal defect on the injected ctscan) of cruoric or tumoral origin or circumferential stenosis of the portal vein trunk, the spleno-mesaraic confluence or one of its venous branches with or without signs of portal hypertension on ctscan and / or upper giendoscopy exclusion criteria: * - post-surgical portal vein thrombosis and / or in patients considered in remission * non-adenocarcinomatous pancreatic tumor (endocrine, etc.)
diagnostic performance of exome sequencing in autism spectrum disorders

Conditions: Autism Spectrum Disorder

Summary: evaluation of the diagnostic performance of exome sequencing in a prospective series of patients with autism spectrum disorders (asd).


Eligibility criteria:
inclusion criteria: * patient with asd who has been previously diagnosed by an expert center according to the dsm5 criteria using standardized instruments (ados, adi-r), referred to genetic consultation by the psychiatrist who performed the clinical diagnosis, according to the recommendations of the has, and requesting a genetic analysis for medical purposes in this context. * patient over 3 years old * patient affiliated to a social security scheme * for minor patients: holders of the exercise of parental authority who have read and understood the newsletter and signed the consent form * for a major patient: major patient who has read and understood the newsletter and signed the consent form * supervised minor / minor patient: legal representative who has read and understood the newsletter and signed the consent form * major patient under guardianship: major patient assisted by his curator or by the judge having read and understood the newsletter and signed the consent form * dna of the patient and parents available exclusion criteria: * patient who has already benefited from exome sequencing * person deprived of liberty by an administrative or judicial decision * pregnant or lactating woman
immune response of haemodialysis patients post covid-19 vaccination

Conditions: Immune Response Post Covid 19 Vaccination

Summary: the purpose of this study is to assess immune response of end stage renal failure patients after covid 19 vaccination


Eligibility criteria:
inclusion criteria: * esrf patient on hemodialysis who are eligible for the goverment covid 19 vaccination programme * 18 years old and above * consented to join the study exclusion criteria: * patient who refused to be vaccinated * patient who deemed unsuitable for covid vaccination
investigate the effect of different doses of lesogaberan (azd3355) as add-on to ppi in gerd patients with partial response to ppi

Conditions: Gastroesophageal Reflux Disease; Heartburn; Regurgitation

Summary: this study is being carried out to see whether azd3355 is an effective treatment as an add-on to ppi therapy in patients with gastroesophageal reflux disease (gerd) with a partial response to ppi and to compare this with proton pump inhibitor (ppi) treatment alone. another goal of the study is to examine which of the investigated doses of azd3355 is optimal for treatment of these patients. this study will also measure levels of drug in the blood and see how well it is tolerated.


Eligibility criteria:
inclusion criteria: * provision of informed consent prior to any study specific procedures * have at least 6 months history of gerd * continuously treated during the last 4 weeks before enrolment with daily optimized unchanged ppi therapy for any gerd indication exclusion criteria: * patients that have not experienced any gerd symptom improvement at all during ppi treatment * prior surgery of the upper gastrointestinal tract. * subject who have any of the following conditions or diseases: heart disease, angina, seizure disorders such as epilepsy, congestive heart failure (chf), liver disease such as cirrhosis or hepatitis, kidney disease, lung disease or lung cancer, cancer

Keywords: gerd treatment acid and non-acid reflux heartburn regurgitation add-on treatment to ppi
home within the heart: a playful journey to strengthen family resilience

Conditions: Family Resilience; Short-term Therapy; The Integration of Narrative Therapy and Play Therapy

Summary: the primary aim of this clinical trial is to enhance open and secure communication within the family, strengthen the parent-child bond, and reinforce feelings of safety and stability, and strengthen family resilience. in addition,the investigators want to assess the effectiveness of a short-term therapeutic workshop in enhancing reflective functioning, beliefs about the malleability of emotions, the reported use of effective emotional regulation strategies, and the perceived parental self-efficacy and child behavior.

the participants will: complete questionnaires and participate in clinical interviews regarding their relationship with their children and their mental functioning prior to the workshop. the intervention group will engage in a 4-session workshop (held once a week) facilitated practitioners from various therapeutic disciplines, including clinical, educational, and developmental psychologists, as well as group facilitators. during each session, observers document the quality of the interaction between the parent and child, focusing on aspects such as emotion, responsiveness, encouragement, and instruction. after the workshop, participants will again complete questionnaires.

Eligibility criteria:
inclusion criteria: a parent who have been evacuated from war zones in the northern and southern regions of the country, and has a child of ages 3-6. exclusion criteria: * a parent under the age of 18. * a parent who have not been evacuated from war zones. * a parent who has a child under 3 years of age, or above 6 years of age.

Keywords: play therapy family resilience reflective function situational anxiety children's mental well-being parental mental well-being