Kornimate/medical-research-clean huggingface dataset:
taste physiology in obese volunteers before and after bariatric surgery

Conditions: Obesity

Summary: the objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional mri before and after bariatric surgery. intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain mri in obese humans before and 3 months after surgery.


Eligibility criteria:
inclusion criteria: * morbidly obese patients (bmi min 35kg/m2) scheduled for bariatric surgery * right handed exclusion criteria: * cardiovascular disease * neurologic/psychiatric disorders
skeletal muscle strain injuries and the connective tissue: characterization, recovery and optimal treatment

Conditions: Muscle Strain

Summary: firstly, the investigators aim to study the biochemical, structural and functional changes associated with acute muscle strain injury in the acute phase and during rehabilitation in vivo. specific factors present after the injury and their effects on connective tissue cells will be examined in vitro. secondly, the investigators will investigate individuals with chronic pain, scar tissue and inferior function after a previous muscle strain injury and test a specific rehabilitation program to alleviate pain and disabilities associated with the preceding muscle injury. the investigators have the following hypotheses: 1. humoral growth factors and pro-inflammatory macrophages released into the injured area post strain injury stimulate formation of connective tissue in vitro. 2. early onset of rehabilitation will be superior to a delayed start of rehabilitation for the healing process, in regards to structural improvement of tissue and better clinical function. 3. scar tissue following a muscle strain injury is characterized by disorganized structure of connective tissue. 4. mechanical loading in the form of heavy eccentric muscle activity for 12 weeks will lead to a local re-modeling of scar tissue, and result in improved function and reduced symptoms in patients with chronic pain and impaired function after a previous muscle injury.


Eligibility criteria:
inclusion criteria: * acute muscle strain injury * chronic muscle strain injury * age above 18 years exclusion criteria: * daily intake of non-steroidal anti-inflammatory drugs (nsaids) within three months prior to the injury * smoking * diabetes * connective tissue and/or rheumatic diseases * any observed organ dysfunctions
perioperative immune function and clinical complications in pancreaduodenectomy

Conditions: Pancreas Cancer

Summary: perioperative immunologic signatures can predict the risk of postoperative complications. the results will be puplished as two smanuscripts. the manuscript will focus on preoperative immunologisk data,the second manuscript will include both pre- and postoperative data.

objective establish evidence for perioperative immunologic risk stratification of patient's risk for clinically postoperative inflammatory complications as a basis for future mechanism-based intervention studies. combining detailed immune assessment from cell-receptors to cell expression, cytokines, and complications with a temporal aspect is innovative and provides highly warranted novel multidimensional immunological insight. methods adult patients scheduled for pd on the suspicion of pancreatic cancer excluding patients receiving immunomodulating treatment 1 month properatively and/or autoimmune diseases. patients scheduled for simultaneous procedures on major blood vessels, and/or adjacent organs (spleen, liver) are also not included. inoperable patients, for instance, due to carcinosis, circulatory/ventilatory instability hindering procedure completion and/or concomitant surgery on major blood vessels, spleen, or liver, are excluded post-inclusion and will not be part of the primary analysis. patients eligible for inclusion will be identified before their appointment at the gastrosurgical dept., rigshospitalet which is the largest dk and north-european center with about 200 pd/yr annually. primary outcome: persistent postoperative hypotension, defined as need for vassopressor infussion on the morning after surgery to maintain middle arterial bloodpressure \>65 mmhg

Eligibility criteria:
inclusion criteria: * scheduled for pd on the suspicion of pancreatic cancer * patients able to follow standardised surgical procedure including tiva anaesthesia with epidural exclusion criteria: * bilirubin \>100 µmol/ltr * patients receiving immunomodulating treatment 1 month properatively and/or autoimmune diseases and patients non-cenacerous cystic lessions * patients scheduled for simultaneous procedures on major arterial blood vessels, and/or adjacent organs (spleen, liver) * inoperable patients, for instance, due to carcinosis, circulatory/ventilatory instability hindering procedure completion and/or concomitant surgery on major arterial blood vessels, spleen, or liver, are excluded post-inclusion and will not be part of the primary analysis * ongoing treatment with glucocortocoid, anti-tnf-alpha etc. * patients diagnosed with rheumatological diseases, ibd or chronic infection (eg. hiv)
comparing cgm and ogtt in relation to iron overload detected by pancreas t2* mri in high-risk hematology group

Conditions: Iron Overload; Hemoglobinopathies; Lymphoma; Acute Lymphoblastic Leukemia

Summary: a prospective, observational, comparative study with no intervention.the objective of the study to compare the efficiency of detecting glycemic abnormalities using continuous glucose monitoring (cgms) versus oral glucose tolerance test (ogtt) and hba1c (glycated hemoglobin) and their relation to iron overload detected by t2\* mri of the pancreas in high-risk patients due to insulin deficiency (potential beta cell injury) and those with insulin resistance and to study the different factors that may affect the glycemic control in these patients in relation to their results like the dose of corticosteroids and chemotherapy in all and hemoglobinopathies, liver function in all and hemoglobinopathies, and serum ferritin in hemoglobinopathies and their transfusion status. using validated tools with permission, the participants will be selected through probability (random) sampling method with expected subjects numbers all/l: 30-50, thalassemia major: 20, sickle cell disease: 20.


Eligibility criteria:
inclusion criteria: * this study will include participants who are high-risk patients to develop glycemic abnormalities: 1. thalassemia major and scd (beta cell toxicity and hepatic siderosis) 2. all/l ( beta cell injury and hepatic injury due to chemotherapy, and insulin resistance due to corticosteroids) exclusion criteria: * age \< 14 years; * other systemic diseases, renal disorders or malnourished; * patients and unwilling to participate in the study.
early enteral nutrition for severe acute pancreatitis

Conditions: Acute Necrotizing Pancreatitis

Summary: there is increasing evidence that indicates early enteral nutrition may be associated with improved outcome in acute pancreatitis patients. however, most of the clinical trials regarding this targeted mild to moderated pancreatitis patients. in regard to severe acute pancreatitis (sap) patients, current results from randomized control trials (rcts) are inconclusive. the researchers of this study aim to investigate the impact of early enteral nutrition on the clinical outcomes of sap patients.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of severe acute pancreatitis * consent informed exclusion criteria: * diabetes mellitus * allergy for any ingredient of pn or en regimen * pregnancy

Keywords: acute severe pancreatitis nutritional support enteral nutrition parenteral nutrition
differential impact of pringle and portal vein occlusion on myocardial injury after non-cardiac surgeries.

Conditions: Myocardial Injury After Non-Cardiac Surgery; Ischemia Reperfusion Injury

Summary: this study aims to investigate the impact of hepatic ischemia-reperfusion injury (hiri) on the incidence of myocardial injury after non-cardiac surgery (mins) and explore the potential underlying mechanisms. a bidirectional cohort study will be conducted, enrolling patients scheduled for major hepato-biliary surgery. clinical data, perioperative parameters, and postoperative follow-up data will be systematically collected. the incidence of mins between patients undergoing pringle occlusion and portal vein occlusion will be compared, and a multivariate analysis will be performed to identify independent risk factors for mins, providing a basis for early recognition and prevention of mins.

this observational cohort study consists of both retrospective and prospective components. the study population includes patients undergoing major hepato-biliary surgery (defined as operative time \> 4 hours and postoperative icu admission) who are either ≥ 65 years old or ≥ 45 years old with cardiovascular risk factors (especially known cardiovascular disease). the exposed group (pringle group) consists of patients who experience liver ischemia-reperfusion injury due to pringle occlusion during surgery. the control group (portal vein group) consists of patients who experience liver ischemia-reperfusion injury due to portal vein occlusion. the primary outcome is the incidence of mins (myocardial injury after non-cardiac surgery) within 3 days postoperatively. secondary outcomes include postoperative length of hospital stay, incidence of complications within 30 days postoperatively, and 1-year survival rate. finally, liver and blood samples will be collected from a subset of patients in the prospective liri group for pathophysiological mechanism investigation.

Eligibility criteria:
inclusion criteria: * age ≥ 65 years, or ≥ 45 years with cardiovascular risk factors (especially known cardiovascular disease). * undergoing elective major hepatopancreatobiliary surgery under general anesthesia. * asa physical status ii-iii. * provide written informed consent to participate in the study (applicable to the prospective cohort). exclusion criteria: * emergency surgery * preoperative diagnosis of myocardial infarction or unstable angina * severe hepatic insufficiency (child-pugh class c) * concomitant severe organ dysfunction (e.g., renal failure, respiratory failure) * concomitant active infectious disease

Keywords: liver ischemia reperfusion injury myocardial injury after non-cardiac surgery major hepato-biliary surgery pringle occlusion portal vein occlusion
uncut roux-en-y vs roux-en-y

Conditions: Uncut Roux-en-Y; Roux-en-Y; Gastric Cancer

Summary: uncut roux-en-y vs roux-en-y reconstruction after distal gastrectomy for gastric cancer

to search which is the better reconstructions by comparing and analyzing the advantages and disadvantages between uncut roux-en-y and roux-en-y reconstructions after laparoscopy-assisted distal gastrectomy for gastric cancer. method: it's a prospective study including all patients underwent laparoscopy-assisted distal gastrectomy (ladg) in the first hospital of jilin university. all surgical procedures will be performed by the single surgery team, which is leaded by professor wang quan. the reconstruction method will be selected randomly from uncut roux-en-y and roux-en-y anastomosis preoperatively without distinct indications. all clinical data, operation data, perioperative complications and related physiological indexes after surgery will be compared.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of distal gastric cancer * underwent laparoscopy-assisted distal gastrectomy exclusion criteria: * have simultaneously other cancer * have severe systemic inflammatory disease ,serious illness such as diabetes, chronic lung diseases * have upper gastrointestinal surgery * can't bear the gastric tube * the period is too late or the tumor is too large to carry on a laparoscopy assisted radical distal gastrectomy

Keywords: uncut roux-en-y roux-en-y
precision therapy based on immune microenvironment by transcriptome sequencing of osteosarcoma, a prospective, multi-cohort exploratory clinical study

Conditions: Osteosarcoma; Transcriptome; Tumor Microenvironment; Precision Medicine

Summary: bagaev et al. have identified four tumor microenvironment (tme) subtypes that are conserved across diverse cancers and correlated with immunotherapy response in melanoma, bladder, and gastric cancers. they provided a visual tool revealing the tme subtypes integrated with targetable genomic alterations, which provided a planetary view of each tumor that can aid in oncology clinical decision making. we aim to use this tool to prospectively analyse the biopsy specimens of osteosarcomas to identify their tme subtypes so as to deliver appropriate treatment strategy if these osteosarcomas experience disease progression afterwards. we will compare the past sequencing date stored in pkuph bank so as to compare the event-free survival(efs) of these patients to check the superiority of this method later.


Eligibility criteria:
inclusion criteria: * (i) patients who have been suspected for osteosarcoma with enough clinical or radiographic information; * (ii) patients who have evaluable lesions to resect or follow; * (iii) patients who are planned to be operate with enough flesh specimens for this study. exclusion criteria: * (i) clinical information was not complete; * (ii) lost to follow-up.

Keywords: osteosarcoma transcriptome tumor microenviroment precision medicine
description of the clinical outcomes of hospitalized patients with heart failure with different serum potassium levels

Conditions: Hyperkalemia; Hypokalemia; Heart Failure

Summary: china national heart failure registration study (cn-hf) is a nationwide, hospital-based, multicentre, prospective registry study sponsored by ministry of science and technology of the people's republic of china. it is aimed to understand the etiology, clinical features and treatments of in-hospital hf patients in china \[3\]. at present, there are few studies to describe the clinical outcomes of hf patients with different sk levels in china. utilizing the cn-hf database, this study is aimed to describe the sk levels of hospitalized hf patients and its impact to the clinical outcomes of patients.

blood potassium disorders are a common phenomenon in patients with hf, which may be related to complications of hf (such as decreased potassium intake, renal insufficiency) and medical treatment of hf (such as diuretics, acei/ arb) \[9\]. it is showed that abnormal changes in sk can cause myocardial cell membrane potential instability, increase the risk of malignant arrhythmia, and result in a high mortality rate \[10\]. current guidelines in china recommend acei/arbs, β receptor blockers, mras, and diuretics for treating hf patients . however, β receptor blockers, acei/arb and mra can also cause hyperkalemia , which often leads to dose reduction or even discontinuation of the medicines, it affects the patients to benefit from these treatment. at present, there are few studies to describe the clinical outcomes of hf patients with different sk levels in china. utilizing the cn-hf database, this study is aimed to describe the sk levels of hospitalized hf patients and its impact to the clinical outcomes of patients.

Eligibility criteria:
inclusion criteria: * hf patients with sk measurements on admission of hospitalization in cn-hf database will be included in this study. exclusion criteria: * not available for this study

Keywords: hyperkalemia, hypokalemia, heart failure, serum potassium,
long-term survival of tha after pelvic and/or femoral osteotomy

Conditions: Hip Arthropathy Associated With Other Conditions; Hip Dysplasia; Survival, Prosthesis

Summary: analyze the long-term clinical and radiological outcomes of total hip arthroplasty (tha) in patients with hip dysplasia treated by pelvic osteotomy, femoral osteotomy, shelf acetabuloplasty, or a combination of these interventions, performed during childhood or early adulthood. the aim is to understand the impact of these early interventions on tha survival and long-term joint function.


Eligibility criteria:
inclusion criteria: * patients who underwent tha between 1998 and 2010 and had a prior surgical treatment for hip dysplasia (pelvic, femoral osteotomy, shelf acetabuloplasty or combined osteotomy) exclusion criteria: -
antipsychotic polypharmacy: prevalence, background and consequences

Conditions: Schizophrenia

Summary: the primary purpose of the study is to investigate whether an intensive educational intervention can reduce the use of antipsychotic polypharmacy. it is hypothesised that the use of antipsychotic polypharmacy is, in some degree, dependent on non-patient related factors.

several surveys have shown a high prevalence of antipsychotic polypharmacy (concomitant prescription of at least 2 different antipsychotics) among patients with schizophrenia even though international guidelines recommend monotherapy. from register data areas with differences in the prevalence of antipsychotic polypharmacy will be identified. two high prevalence areas will be randomized to either control or intervention area. in the intervention area an intensive educational intervention consisting of outreach visits with a multifaceted approach will be carried out with the duration of 1 year. differences in health staff related factors such as knowledge and attitude towards clinical guidelines will be assessed with a questionnaire before and after the intervention in the intervention area as well as in the low prevalence area at baseline. medical records data describing the use of antipsychotic polypharmacy will be collected. with register data health economic issues will be assessed.

Eligibility criteria:
inclusion criteria: * the intervention is not aimed directly to the patients but their health care providers. * patients with schizophrenia (f2\* diagnosis according to icd-10) taking antipsychotic medication and their health care providers in the specified areas will enter the study: * the patients will enter with data from their medical record, register data and a few exploring interviews while the health staff will enter with their questionnaire data.

Keywords: antipsychotic polypharmacy schizophrenia implementation of clinical guidelines
oral topotecan versus docetaxel in second-line treatment of non-small cell lung cancer

Conditions: Lung Cancer

Summary: in this trial we will evaluate and compare the efficacy and toxicity of oral topotecan with intravenous docetaxel in the second-line treatment of patients with non-small cell lung cancer.

upon determination of eligibility, patients will be randomly assigned to one of two treatment arms: * topotecan * docetaxel for ever 2 patients treated, 1 will receive treatment a (topotecan) and 1 will receive treatment b (docetaxel). the study is not blinded so both the patient and the doctor will know which treatment has been assigned.

Eligibility criteria:
inclusion criteria: to be included in this study, you must meet the following criteria: * relapsed or progressive disease * stage iiib (not candidate for combined modality) or iv * no more than one prior chemotherapy regimen * able to perform activities of daily living without assistance * measurable disease outside of radiation port * adequate bone marrow, liver and kidney function * must understand study and sign informed consent prior to enrollment exclusion criteria: you cannot participate in this study if any of the following apply to you: * prior treatment with topotecan or docetaxel * uncontrolled brain metastases * moderate peripheral neuropathy please note: there are additional inclusion/exclusion criteria. the study center will determine if you meet all of the criteria. if you do not qualify for the trial, study personnel will explain the reasons. if you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
a study of wearable devices to predict migraines

Conditions: Migraine

Summary: the purpose of this research is to determine if data from smart devices, including heart rate and movement during sleep and wake times, will be able to track headaches and predict recurrence and exacerbations (make worse). this use of this information may in the future allow patients earlier and more effective treatments if these devices can help predict when the headaches may occur.


Eligibility criteria:
inclusion criteria: * age 18 years and older (no upper age limit defined) * history of chronic migraine as defined by the international headache society's international classification of headache disorders (3rd edition). * response to current preventative therapy with ≥ 50% improvement in the frequency of headache days when compared to baseline * 4 to 14 average number of total headache days per month during peak efficacy of preventative therapy * ability to understand study procedures and to comply with them for the entire length of the study and use study devices as outlined in protocol. * patient agrees to maintain a daily electronic headache diary. * proficient in the use of electronic devices including apple homekit and apple watch. - subjects owns an iphone with ios 16 or later operating system installed on iphone. apple watch series 8 with watch os6 or later will be provided by the study. exclusion criteria: * chronic daily headache with no periods of headache freedom. * ≥ 15 average number of headaches days per month during peak efficacy of preventative treatment. * medication overuse headache as defined by the international headache society's international classification of headache disorders (3rd edition). * daily opioid use for \> 3 months (e.g., hydrocodone, oxycodone, fentanyl patch) or other daily analgesic use for chronic pain disorders (e.g., nsaids or acetaminophen). * inability or unwillingness of individual or legal guardian/representative to give written informed consent.
sars-cov-2 pre-exposure prophylaxis with ivermectin retrospective cohort study

Conditions: Covid19

Summary: this observational study, a multicenter retrospective cohort database study, carried out in two medical centers, centro medico bournigal (cmbo) in puerto plata and centro medico punta cana (cmpc) in punta cana, dominican republic, sought to determine whether ivermectin, at a weekly orally dose of 0.2 mg/kg, is an effective pre-exposure prophylactic method (prep) for the spread of severe acute respiratory syndrome coronavirus 2 (sars-cov-2), in the healthcare workers. the study began on june 29, 2020 and ended on july 26, 2020 (4 weeks).


Eligibility criteria:
inclusion criteria: * active workers from centro medico bournigal (cmbo) and centro medico punta cana (cmpc) during the study. exclusion criteria * workers with positive covid-19 rt-pcr prior to the start of the study * those that did not take the first dose of ivermectin the first week at the start of the study * those that did not complied with at least 2 out of 4 weekly doses * those that had greater than 14 days difference in days between two intakes ivermectin

Keywords: ivermectin sars-cov-2 coronavirus prophylaxis prep covid-19