Kornimate/medical-research-clean huggingface dataset:
oxidative stress in polycystic ovary syndrome

Conditions: Polycystic Ovarian Syndrome (PCOS); Oxidative Stress

Summary: the aim of the study was to determine changes in hematological and biochemical parameters and specific oxidative stress markers in patients with pcos.


Eligibility criteria:
inclusion criteria: the pcos group included patients with oligomenorrhea (menstrual period intervals of more than 35 days), clinical signs of hyperandrogenism (acne or hirsutism), biochemical signs of hyperandrogenism (with total testosterone of 100 ng/dl and above and patients with dehydroepiandrosterone sulfate of 400 g/dl and above), an lh/fsh ratio of over 3 on the second day of the menstrual period, a body mass index of 25 and above, and polycystic ovaries detected in suprapubic ultrasonography. exclusion criteria: pregnant individuals, individuals with diabetes mellitus, metabolic syndrome, adrenal pathology, pelvic mass, and malignancy were not included in the study.
treatment of central airway stenoses using computer-assisted customized 3d stents tatum

Conditions: Airway Disease

Summary: airway stenting is usually efficient to treat central airway obstruction but can lead to severe and potentially lethal complications (stent migration, obstructive granuloma, perforation, and hemoptysis). 3d customized airway stents (computer-aided conception using ct-scan data), perfectly suited to airway anatomy, should improve the tolerance and safety of airway stenting. we demonstrated in a previous pilot study, dedicated to patients with anatomically complex stenoses the safety of 3d patient-specific stents. these appealing results in highly complex situations suggest the need to evaluate these devices in more common situations. in this study we aim to test our new generation stents in all patients planned for airway stenting. after computer-assisted segmentation of airways (vgstudiomax 3.0 software), the stenosis is virtually corrected, leading to the conception of a virtual stent (anatomikmodeling, toulouse), allowing for the fabrication of a mold using a 3d printer. the stent is then built and sterilized (novatech, berlin) and inserted during rigid bronchoscopy. close follow up is then conducted, including clinical evaluation after one week, three, six and 12 months; spirometry at one week, 3 months, 6 months and 12 months and chest ct-scan at one week.


Eligibility criteria:
inclusion criteria: * age \>18 years * informed consent * complex, proximal and symptomatic (dyspnea, cough, peak flow \< 50%, fev1 \< 50% or post-stenotic infection) airway stenosis exclusion criteria: * acute respiratory distress, mechanical ventilation * contraindication to rigid bronchoscopy (severe and irreversible coagulation disorders) * pregnancy

Keywords: rigid bronchoscopy 3d computer-assisted fabrication silicon-dedicated stent
effect of aprv and ltv on lung ventilation and perfusion in patients with moderate-to-severe ards

Conditions: Acute Respiratory Distress Syndrome

Summary: low tidal volume ventilation (ltv) has been proposed and widely used in patients with acute respiratory distress syndrome (ards) to prevent ventilator-induced lung injury (vili) and mitigate its effects. the ltv strategy is intended to protect the "baby lung" from overdistension while simultaneously allowing acutely injured tissue to continually collapse. airway pressure release ventilation (aprv) is a highly effective strategy improving lung recruitment and oxygenation in clinical studies, but its effects on lung injury and mortality is debatable. animal studies revealed that aprv could normalize post-injury heterogeneity and reduce the risk of vili. our objective was to investigate the impact of aprv and ltv on regional ventilation and perfusion distribution in ards patients by electrical impedance tomography (eit).


Eligibility criteria:
inclusion criteria: 1. patients aged ≥18 and ≤80 years; 2. moderate-to-severe ards patients according to the berlin definition; 3. endotracheal mechanical ventilation ≤48 h before enrollment; 4. expected to require continuous invasive mechanical ventilation ≥72 h. exclusion criteria: 1. severe chronic obstructive pulmonary disease, severe asthma, pulmonary bulla, subcutaneous emphysema, mediastinal emphysema, etc; 2. contraindications to the use of electrical impedance tomography (e.g., chest surgical wounds dressing or presence of pacemaker)； 3. pulmonary interstitial lesions； 4. end-stage of chronic disease, with an expected survival period of \<6 months； 5. body mass index \>35 kg/m2; 6. refractory shock； 7. intracranial hypertension； 8. pregnant and parturient woman； 9. intra-abdominal pressure persisted \> 20 mmhg and could not be relieved within 24 hours； 10. severe thoracic deformity； 11. severe cardiac dysfunction； 12. atrial fibrillation and other malignant arrhythmias that seriously affect cardiac output； 13. pulmonary embolism； 14. extracorporeal membrane oxygenation is needed； 15. prone positioning was performed before randomization； 16. patients who have participated in other clinical trials within 30 days； 17. patients who have not signed informed consent.
brief online help-seeking barrier reduction intervention

Conditions: Crisis Intervention; Suicide and Depression

Summary: objective: mental illness is a leading cause of disease burden; however, many barriers prevent people from seeking mental health services. technological innovations may improve the ability to reach under-served populations by overcoming many existing barriers. the investigators evaluated a brief, automated risk assessment and intervention platform designed to increase the use of crisis resources provided to individuals who were online and in crisis. hypothesis: the investigators hypothesized that individuals assigned to the intervention condition would report using crisis resources at higher rates than individuals in the control condition. method: participants, users of the digital mental health app koko, were randomly assigned to treatment or control conditions upon accessing the app and were included in the study after their posts were identified by machine learning classifiers as signaling a current mental health crisis. participants in the treatment condition received a brief barrier reduction intervention (bri) designed to increase the use of crisis service referrals provided on the app. participants were followed-up several hours later to assess the use of crisis services.


Eligibility criteria:
inclusion criteria: * participants identified as experiencing a mental health crisis by a hybrid human-machine computation system evaluating semantic content of posts made on digital platforms. exclusion criteria: * participants who were not identified as experiencing a mental health crisis.

Keywords: suicide mental health crisis crisis referrals help-seeking risk assessment treatment barrier
amg 386, 20060159 phase 2, rcc 1st line in combination with sorafenib

Conditions: Advanced Renal Cell Carcinoma

Summary: this is a phase 2, randomized, double-blind, placebo controlled, multi-center study to estimate the improvement in progression free survival (pfs) and evaluate the safety and tolerability of amg 386 in combination with sorafenib in the treatment of subjects with advanced clear cell carcinoma of the kidney.


Eligibility criteria:
inclusion criteria: * subjects must have a histologically confirmed metastatic rcc with a clear cell component * low or intermediate risk according to the memorial sloan kettering cancer center (mskcc) prognostic risk classification. * measurable disease with at least one unidimensionally measurable lesion per recist guidelines with modifications * adequate organ and hematological function as evidenced by laboratory studies conducted at screening. * ecog of 0 or 1 exclusion criteria: disease related * known history of central nervous system metastases. * previous treatment (excluding surgery and palliative radiotherapy) for advanced or metastatic renal cell carcinoma * focal radiation therapy for palliation of pain from bony metastases within 14 days of randomization. medications * currently or previously treated with inhibitors of vegf. * currently or previously treated with inhibitors of angiopoietin or tie2. * currently or previously treated with bevacizumab. general medical * diagnosis of acute pancreatitis. * myocardial infarction, cerebrovascular accident, transient ischemic attack, percutaneous transluminal coronary angioplasty/stent, congestive heart failure, grade 2 or greater peripheral vascular disease, arrhythmias not controlled by outpatient medication, or unstable angina within 1 year prior to randomization * major surgery within 30 days before randomization or still recovering from prior surgery * uncontrolled hypertension as defined as diastolic \> 90 mmhg or systolic \>150 mmhg. anti-hypertensive medications are permitted. other * other investigational procedures are excluded * subject currently is enrolled in or has not yet completed at least 30 days since ending other investigational device or drug study(s), or subject is receiving other investigational agent(s)

Keywords: metastatic clear cell carcinoma of the kidney rcc
peer support in diabetes management - insulin peer support

Conditions: Type 2 Diabetes Treated With Insulin

Summary: this project will develop a combined model of the shanghai integration model and peer support for diabetes self-management with a special focus on appropriate insulin use.

the development of contemporary diabetes care offers new hope for long and satisfying lives of those with the disease, but also provides increased challenges for integration across the many dimensions of care (varied medications in addition to insulin, specialty services, diet, physical activity, stress management, etc.) and across the many who contribute to care (specialists, primary care providers, nurses, dietitians and patient educators, family members, friends, worksites). the shanghai integration model (sim) has made great strides to integrating specialty/hospital care with primary/community care. the addition of peer support can enhance patient engagement within that integrated care. peer support can also integrate care with the daily behaviors and patterns that optimal diabetes management requires and with the family members and others in individuals' daily lives who can support diabetes management. the "insulin peer support" project is a sub-project of "peer support in diabetes care", with special focus on appropriate insulin use in the community, to help overcome barriers in insulin treatment and improve treatment compliance. this project will develop a peer support model for diabetes management in chinese patients undergoing insulin treatment and evaluate its effectiveness in a randomized controlled trial of 10 chcs in shanghai. the project is a collaboration among the shanghai sixth people's hospital, shanghai jiao tong university, the shanghai diabetes institute,the shanghai municipal commission of health and family planning, the shanghai centers for disease control, and, at the university of north carolina-chapel hill, peers for progress, widely recognized for its leadership in promoting peer support in health care and prevention.

Eligibility criteria:
inclusion criteria: * chinese * has type 2 diabetes * receiving treatment at participating community health center * currently using insulin or prescribed insulin but not currently using insulin exclusion criteria: * severe mental illness (severe depression, schizophrenia, bipolar disorder, obsessive compulsive disorder, panic disorder, ptsd, borderline personality disorder, etc.)

Keywords: diabetes self-management primary care community health center peer support group support integrated care insulin china urban
psychological aspects in osa

Conditions: Osa Syndrome

Summary: the research project consists of an observational study. obstructive sleep apnea (osa) is a condition characterized by recurrent episodes of upper airway collapse during sleep, leading to decreased blood oxygen levels and disruptions of normal sleep patterns. estimates of its prevalence vary, but its impact on patients' quality of life is evident. through a qualitative analysis (semi-structured interviews for both patients and bed partners) and a quantitative analysis (apim model), this research aims to explore the perception and awareness of the disease and its impact on the individual and couple's lives of patients with osa and their bed partners, to assess patients' perceptions of the disease, illness management (cpap experience) and symptoms, as well as their bed partners' perceptions. moreover, psychological aspects of living with osa, such as perceived stress, depression, anxiety, sleep quality, daily sleepiness will be studied to observe the association with continuous positive airway pressure (cpap) adherence.

firstly, a series of semi-structured interviews will be conducted with patients with osa, at different levels of cpap adaptation as well as with bed partners of patients who are experiencieng cpap treatment with osa. after that, a quantitative analysis will be conducted to explore dyadic dynamics between patients with osa and their bed partners.

Eligibility criteria:
inclusion criteria: * adult outpatient patients * over 18 years of age * diagnosis of obstructive sleep apnea syndrome * absence of cognitive impairments * having a bedpartner exclusion criteria: * oncological comorbidities * dementia, as reported in the medical record * ongoing treatment with phosphodiesterase-5 inhibitors, hypogonadism, or severe lung diseases * exacerbations requiring hospitalization or the use of corticosteroids and antibiotics in the last two months * lack of consent * lack of a bedpartner

Keywords: quality of life couple relationship quality cpap sleep apnea sleep disturbance adherence to treatment
effects of different add powers on the comfort and productivity of computer users with fixed or free head movement

Conditions: Refractive Errors; Asthenopia

Summary: the aim of this study is to examine the relationship between optical blur from poor refractive corrections (glasses) of older workers using computers and their productivity and comfort in the workplace. the investigators believe that improving the visual status of subjects who use computers will have a beneficial effect on productivity and visual comfort.

the aim of this study is to examine the relationship between optical blur from poor refractive corrections (glasses) of older workers using computers and their productivity and comfort in the workplace. we believe that improving the visual status of subjects who use computers will have a beneficial effect on productivity and visual comfort. all subjects will be required to complete a vision screening at no charge to decide if they qualify for the study. this is a double-blind study, which means that neither the subject nor the doctors will know which pair of lenses you will be wearing during the parts of the study. subjects will complete a total of 4 hours of testing. the total amount of testing will be divided into ten 15-minute periods. during each period, the investigator will place different lenses in a trial frame. the trial frame that the subject will wear during the experiment will have their prescription for near plus an unknown pair of lenses. during the testing, the subject will complete a task involving finding and deleting apostrophes from a manuscript on a standard computer. either the investigator or co-investigator will explain how to do this simple task. subjects will answer a short survey before and after these tasks to check on symptoms resulting from using the computer. the following periodic measurements will be made during the study: productivity and accuracy to search for apostrophes (') in a document on one of the states of the u.s. these tasks will require a total of 4 hours testing with a total of ten pairs of trial lenses during a single visit.

Eligibility criteria:
inclusion criteria: * 40 years of age or greater * 20/40 visual acuity or better in each eye * use a computer at least 1 hour per work day

Keywords: refractive error asthenopia
prophylactic uterosacral ligament suspension at the time of hysterectomy for prevention of vaginal vault prolapse

Conditions: Prolapse of Vaginal Vault After Hysterectomy

Summary: is routine uterosacral ligament suspension an appropriate clinical adjunct at the time of hysterectomy? the answers to these questions will facilitate the treatment of many american women. with the results of this study, the investigators would anticipate a reduction in the number of surgeries for pelvic organ prolapse. in addition, if uterosacral ligament suspension was shown to be ineffective, it would not be used routinely in the setting of hysterectomy and women will be spared the additional procedure and possibility of side effects or complications. the relative risks and benefits of adding a prophylactic uterosacral ligament suspension at the time of hysterectomy in women without symptomatic prolapse symptoms have never been studied prospectively.


Eligibility criteria:
inclusion criteria: * eligibility for primary procedure (hysterectomy either total or supracervical, performed either vaginally or abdominally, via laparoscopic or open approach) * eligibility for secondary procedure (uterosacral ligament suspension colpopexy) * prolapse in any compartment not extending beyond the hymen as measured by pelvic organ prolapse quantitative system * no subjective complaints of pelvic organ prolapse as determined by answer "no" to questions #3 of the short form of pelvic floor distress inventory: #3. do you usually have a bulge or something falling out that you can see or feel in the vaginal area? exclusion criteria: * contraindication for uterosacral ligament suspension colpopexy. (surgeon's judgment that a contraindication to uterosacral ligament suspension colpopexy exists). * anticipated geographic relocation within the 12 months after surgery * inability to provide informed consent or to complete testing or data collection.
effects of shotblocker and manual pressure on pain and satisfaction

Conditions: Pain; Satisfaction

Summary: this study aims to determine the effects of shotblocker and manual pressure applied during peripheral venous catheter placement on pain and satisfaction. 81 patients hospitalized in the urology clinic will be included in the study. patients will be assigned to three groups as shotblocker (n=27), manual pressure (n=27) and control group (n=27) by block randomization method. research hypotheses * h1-1: the mean pain scores of the intervention group to which shotblocker was applied during peripheral intravenous catheterization are different from the control group. * h1-2: the mean pain scores of the intervention group to which manual pressure was applied during peripheral intravenous catheterization are different from the control group. * h1-3: the mean satisfaction scores of the intervention group to which shotblocker was applied during peripheral intravenous catheterization are different from the control group. * h1-4: the mean satisfaction scores of the intervention group to which manual pressure was applied during peripheral intravenous catheterization are different from the control group.


Eligibility criteria:
inclusion criteria: * admission to the urology clinic, * no verbal, perceptual and visual communication problems, * between the ages of 18 and 65, * literate, * volunteer to participate in the study, * not using medication that will create a chronic analgesic effect, * not having chronic or acute pain, * no intervention has been performed on the vein where the pic is placed in the last month, * no scar tissue or infection in the areas where the pic will be placed, * not having a disease that will cause problems in feeling pain (such as neuropathy) exclusion criteria: * the individual wants to leave the study, * feels unwell during the pic placement (such as dizziness, palpitations), * uses sedatives or alcohol,
allograft dysfunction in heart transplant

Conditions: Heart Transplant Failure and Rejection

Summary: the investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac mri and single cell sequencing to determine underlying molecular and macroscopic causes.

adult heart-transplant patients, excluding those with a gfr less than 30 ml/min/1.73m2, contraindications to mri and allergies to either regadenoson or gadolinium contrast, will be enrolled over 60 months. patients will be recruited from ucsd. the investigators will specifically enroll all eligible heart-transplant patients. brief protocol: cardiac mri is performed. cine images in standard views are obtained. t1 and t2 mapping sequences are performed on short axis images pre- and post-gadolinium contrast. for stress imaging, intravenous regadenoson is given as a 0.4 mg bolus followed by a 5 ml saline flush. after 30 seconds, short-axis images are acquired for 30 consecutive heartbeats with administration of gadolinium. rest imaging is performed 30 minutes after stress imaging. lastly, late gadolinium enhancement images are obtained in standard views. images are analyzed offline by a blinded independent reader. patients will be followed for at least 1 year after enrollment for mace. peripheral blood and endomyocardial biopsies will also be collected, timing as per usual clinical care as well as for-cause, for single cell rnaseq analyses.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years old. * at least three months status post heart transplantation. exclusion criteria: * biopsy proven acute rejection episode in the past 3 months. * patients with symptoms or signs of acute myocardial ischemia or recent acute coronary syndrome in the past 3 months. * uncontrolled obstructive ventilatory disease including asthma and copd. * history of generalized tonic-clonic seizures. * second or third degree av nodal block. * sinus node dysfunction. * contraindications to mri including cardiovascular implantable electronic devices. * renal dysfunction with an estimated gfr less than 30 ml/min/1.73m2. * prior adverse reaction to either regadenoson or gadolinium contrast. prior adverse reaction to adenosine or dipyridamole will be assessed on a case-by-case basis. * systolic blood pressure greater than 180 or less than 85 mmhg. * diastolic blood pressure greater than 120 or less than 40 mmhg. * resting heart rate greater than 120 or less than 45 beats per minute. - severe claustrophobia.

Keywords: heart transplant acute graft rejection chronic graft rejection
urokinase therapy in patients with diabetic foot syndrome

Conditions: Diabetic Foot; Arterial Occlusive Disease; Ischemia

Summary: the purpose of this study is to determine whether the additional therapy with low dose urokinase is more effective than only a conventional standard therapy concerning ulcer-healing, rate of major amputation and survival.

patients with diabetic foot ulceration and critical limb ischemia have a high risk of major amputation, especially if limbs can not be revascularized. urokinase is effective in critical limb ischemia by lowering fibrinogen and might improve outcomes. the effect and safety of urokinase treatment was investigated in a phase ii clinical trial. based on the results this trial was planned to investigate the effect and safety of an additional therapy with urokinase versus a single conventional therapy.

Eligibility criteria:
inclusion criteria: * diabetic patients with angiopathic or angioneuropathic diabetic foot syndrome and criticial limb ischemia * no surgical or interventional treatment option * no healing tendency of ulcerations despite of antibiosis and wound debridement after two-week treatment * fibrinogen \> 4.0 g/l * no previous major amputation exclusion criteria: * prior treatment of the current ulceration with urokinase * need for dialysis and/or creatinine-clearance \< 20ml/min * inr \> 1,5 at screening * any kind of cerebral event within 3 months prior inclusion * proliferative retinopathy * uncontrolled hypertension * hemorraghic diathesis * gastrointestinal bleeding * pregnancy * no compliance and/or participation in another trial

Keywords: diabetes urokinase ulcer healing major amputation survival