Kornimate/medical-research-clean huggingface dataset:
registry of cardio/neurovascular anesthesia including the database of biological signals during anesthesia, preoperative assessment and prognosis in patients

Conditions: Cardiac Anaesthesia

Summary: the purpose of this study is to establish a registry database for patients undergoing anesthesia for cardiovascular surgery or procedures in our operating or hybrid room. the following information will be collected: 1. preoperative patient assessment 2. all monitored perioperative biosignal data 3. intraoperative and immediate postoperative hemodynamic information, input/output balance, and medication usage 4. short- and long-term prognosis from electronic medical records this database will be used to develop a vigilant monitoring system that integrates multiple biosignal data simultaneously, contributing to the improvement of anesthesia care.


Eligibility criteria:
inclusion criteria: 1. adults age 19 and older 2. patients scheduled for anesthesia at a cardiovascular hospital for cardiovascular surgery or procedures exclusion criteria: 1) emergency (surgery/procedure room transfer within 1 hour of visit) where there is insufficient time for the subject (adult 19 years of age or older) or his/her representative (adult incapable of consent) to decide whether to participate in the study

Keywords: cardiac diseases biosignal data cardiac surgical procedures cardiovascular surgical procedures heart valve prosthesis implantation
study of apremilast use in patients with psoriatic arthritic in practice conditions

Conditions: Arthritis, Psoriatic

Summary: a total of approximately 500 patients with active psoriatic arthritis in an estimated 80 to 100 trial centers are to be enrolled. selection of centers will be made by the sponsor's medical section. to increase the quality of the data and to reduce distribution of the data collected, centers to be included will be those which can enroll at least 5 patients. care will be taken to ensure a balanced regional distribution. the proposed observation period for the trial is approx. 52 weeks per patient. estimated patient enrolment is also 52 weeks. the duration of the follow-up period will be extended from approx. 52 weeks to approx. 100 weeks to gain further information about the long-term use of otezla®. for this extension of the follow-up period 2 new visits (visits 6 and 7) are proposed.thus, proposed duration from first patient in (fpi) to last patient out (lpo) is 36 months-


Eligibility criteria:
inclusion criteria: * the decision to treat with otezla® has been made independently before inclusion in this study * patient age ≥ 18 years * existing diagnosis of active psoriatic arthritis * at least moderately severe psoriatic arthritis (physician's global assessment (pga) scale ≥ 2) * insufficient response or intolerance to previous disease-modifying anti-rheumatic drug (dmard) treatment (disease modifying anti-rheumatic drugs) * a written informed consent statement by the patient permitting data collection, evaluation, storage and transfer exclusion criteria: * pregnancy * hypersensitivity to apremilast or one of the other ingredients in the film tablets * other criteria according to the summary of product characteristics breast-feeding

Keywords: arthritis psoriatic observational apremilast
intravitreal bevasizumab vs sham treatment in acute brvo: a randomized clinical trial

Conditions: Retinal Disease

Summary: in this study we intend to evaluate the outcome of intravitreal avastin on improving the visual acuity and macular edema and late complications of brvo like nvd and nve

after diabetic retinopathy, vein occlusion is the second most common retinovascular disease. according to bvo study the only effective management of it is macular photocoagulation for macular thickening that persist after 3 months.but we may miss a golden time which resulted to photoreceptor degeneration due to macular edema during this period. vegf inhibitors newly have been shown that may be effective on a wide range of retinovascular diseases that resulted to macular edema or new vessels formation. in this study we aim to show the outcomes of one of this vegf inhibitors (bevacizumab) on complications of brvo in a sham controlled clinical trial.

Eligibility criteria:
inclusion criteria: * patients with acute brvo with less than three month duration exclusion criteria: * vision less than 20/320 and vison more than 20/50 * duration more than 3 months * history of glaucoma and diabetic retinopathy * any media opacity that prevent funduscopy

Keywords: intravitreal avastin brvo macular edema
feasibility study: the effect of prazosin for nighttime symptoms of civilian ptsd

Conditions: Stress Disorders, Post-Traumatic

Summary: investigating the effect of prazosin for nighttime symptoms of civilian posttraumatic stress disorder.

each subject will receive prazosin and placebo trials, the order randomized. day and nighttime symptoms will be monitored.

Eligibility criteria:
inclusion criteria: * must meet dsm-iv criterion for ptsd exclusion criteria: * must not have untreated sleep apnea
matrix metalloproteinase-1/tissue inhibitor of metalloproteinase-1 (mmp-1/timp-1) ratio and diabetic foot ulcers

Conditions: Diabetic Foot Ulcer

Summary: the primary objective of this study is to assess the sensitivity and specificity of a mmp-1/timp-1 ratio equal to 0.24 at study entry to predict wound healing at 12 weeks' follow up visit.

this monocentric, prospective, non-randomized study assesses the amount of the main metalloproteinases (mmp1, mmp9, mmp13) and their inhibitor timp-1 in wound fluid from diabetic foot ulcers. it aims at demonstrating whether a mmp-1/timp-1 ratio equal to 0.24 at study entry can predict wound healing 12 weeks later. all patients will receive the same treatment according to our local protocol. the difference with standard care will be a sample of wound fluid at week 0 and week 4 and a numeric photograph for wound area measurement at week 0, week 4 and week 12. the main outcome measurement is the percent change of wound area between week 0 and week 12 secondary objectives include the evaluation of a mmp-1/timp-1 ratio equal to 0.4 and the search for confounding factors. a correlation between mmp-9, mmp-13 and wound healing will also be investigated.

Eligibility criteria:
inclusion criteria: * patients with type 1 or type 2 diabetes * age over 40 * chronic diabetic foot ulcer (duration over 30 days) * grade 1 to 3, stage a and c according to the university of texas wound classification, except stage b and d * wound area over 0.5 cm² * social security membership or benefit from social security * informed consent, with a signed and approved form * possibility to have clinical follow-up and compliance during 3 months exclusion criteria: * urgent need for locoregional surgery * clinical criteria for infection, defined by the presence of pus or/and at least 2 local signs among the following: heat, erythema, lymphangitis, lymphadenopathy, oedema, pain * other pathology that could interfere with the healing process (vasculitis, connectivitis, dysimmunity, immunosuppressive treatment or corticoids, ongoing radiotherapy or chemotherapy ) * any severe pathology that would constitute a contra-indication to the patient's inclusion * ongoing therapeutic research protocol * underage patient, major patient under guardianship or protected by the law * pregnant, parturient or breastfeeding woman * person with no freedom (prisoner), person in an emergency situation, person hospitalized without consent and not protected by the law

Keywords: type 1 diabetes type 2 diabetes diabetic foot ulcer
effect of cpap on fetal ph at scheduled c-section in morbidly obese women

Conditions: Morbid Obesity; Cesarean Delivery Affecting Fetus

Summary: the objective of our study is to evaluate the effect of cpap on umbilical cord acid base status in morbidly obese women at the time of scheduled cesarean delivery. we hypothesize that neonates born to mothers wearing cpap during the cesarean section will have a higher umbilical artery ph.

this is a randomized control trial comparing cpap to routine airway management in morbidly obese patients undergoing scheduled cesarean delivery. morbidly obese women meeting criteria for inclusion will be approached for participation. women who are scheduled for cesarean delivery at sentara norfolk general hospital will be approached at a prenatal appointment prior to scheduled date of delivery. if a woman agrees to participate in the study, she will be counseled and consented at that time.

Eligibility criteria:
inclusion criteria: * pregnant women between the ages of 18-45 * body mass index of 40 kg/m2 or greater at the time patient is scheduled for cesarean delivery * singleton gestation * scheduled for primary or repeat cesarean delivery at sentara norfolk general hospital * gestational age between 37+0 and 41+0 weeks at the time of delivery * non-stress test on admission with moderate variability, without repetitive late or variable decelerations * negative sars-cov-2 pcr test within 72 hours of procedure exclusion criteria: * fetal growth restriction * active pulmonary diseases to include pneumonia, sarcoidosis, pulmonary hypertension, moderate or severe persistent asthma * suspected placenta accreta based on prenatal sonographic evaluation * active maternal infection to include pyelonephritis, appendicitis, upper respiratory tract infection, urinary tract infection or suspected intra-amniotic infection * sars-cov-2 positive test within past 10 days or ongoing symptoms of sars-cov-2 to include cough, fever or shortness of breath with positive test greater than 10 days prior, or history of hospitalization for sars-cov-2 infection * fetus with aneuploidy or major anomaly * enrolled in another trial that may affect outcome

Keywords: fetal ph cpap continuous positive airway pressure
study of left side of laparoscopic cholecystectomy

Conditions: Cholecystitis

Summary: prospectively selected 100 cases of patients who suffered from gallstones ro cholecystic polypus and treated with laparoscopic cholecystectomy in our hospital. randomly divided into the experimental group and the control group. the experimental group preserve the main cystic artery, and the control group treated with conventional laparoscopic cholecystectomy. collection of statistics: including general data(gender, age, bmi, etc.), time of surgery, intraoperative blood loss, incidence of surgical complications (delayed hemorrhage, biliary injury, etc.) and postoperative pain score, etc.

1. research object (1)patients who suffered from gallstones ro cholecystic polypus. (2)informed and consented to participate in this clinical trial (3)number of enrolled cases：100.（about 700 cases were treated in our hospital） 2. inclusion criteria (1) consistent with the indications of cholecystectomy (2) no cholangitis or pancreatitis (3) no diabetes (4) the operation time is less than or equal to 1 hour 3.exclusion criteria 1. patients with acute cholecystitis 2. cystic arterial variation causes related complications 3. patients receiving analgesic drugs after surgery 4.research methods 4.1 grouping method: random number table method was applied to randomly divide into 2 groups. 4.2 surgical method：laparoscopic cholecystectomy with the preservation of the main cystic artery 1. general anesthesia, use laryngeal mask 2. making co2 pneumoperitoneum through the superior border of umbilical pneumoperitoneum pressure 12 -- 14 mmhg(1 mmhg=0.(133 kpa), the puncture sleeve was placed under laparoscopy according to the three-hole method. 3. to expose the gallbladder triangle, cut the serous membrane of the triangular region along the gallbladder tube, expose the neck and the left half of the gallbladder tube, push the rest tissue of the triangular region (including the main cystic artery, etc.) to the right, and separate the right half of the gallbladder tube, exposing the whole gallbladder tube. 4. cutting off after clipping the gallbladder tube; 5. turn up the gallbladder neck, cut off the superficial and deep branches of the gallbladder artery by electric hook along the gallbladder wall. 6. remove the gallbladder. through the umbilical hole and close the puncture hole. 4.3 main outcome measures (1) general data of patients (gender, age, bmi, etc.); (2) operation time, intraoperative blood loss, surgical complications (delayed hemorrhage, biliary tract injury, etc.) incidence.

Eligibility criteria:
inclusion criteria: 1. consistent with the indications of cholecystectomy 2. no cholangitis or pancreatitis 3. no diabetes 4. the operation time is less than or equal to 1 hour exclusion criteria: 1. patients with acute cholecystitis 2. cystic arterial variation causes related complications 3. patients receiving analgesic drugs after surgery

Keywords: cholecystectomy laparoscopic
utility of mr lymphangiography in postoperative follow-up of lymphedema: comparison with lymphoscintigraphy

Conditions: Lymphedema

Summary: its usefulness in implementing magnetic resonance angiography for postoperative follow-up of lymph lymphedema should try to evaluate and compare lymphoscintigraphy.

surgical methods include " surgical procedure to make a good lymphatic drain 'and' surgical resection with lymph tissue swelling , significant that two of lymphedema .in recent years, began receiving the spotlight this former method using micro-surgery , inde essential that in order to increase the success rate of these micro-surgery accurately assess the structural abnormalities of preoperative lymphatic and establishing the surgical plan , the primary diagnostic imaging examination of existing lymphedema since the nuclear medicine examination as to obtain an accurate anatomical information it is also ideal for imaging in the preoperative assessment of lymphedema is precisely that you can not . in contrast magnetic resonance lymphangiography recently developed a new magnetic resonance imaging techniques that many advantages in precision assessment of lymphedema patients. first, there are high spatial resolution magnetic resonance lymphangiography through the lymphatic vessels to obtain the correct anatomical information . second, magnetic resonance lymphangiography is provide not only information about the functional status of the lymphatic anatomical information . third, the magnetic resonance lymphangiography minimally invasive techniques , without exposure to radiation , is relatively easy and safe , that there is a great advantage of being able to diagnose the structural and functional at the same time or later in lymphatic vessels. the magnetic resonance lymphangiography via the lymphatic advantage given also helps to establish a specific treatment plan , as well as accurate preoperative diagnosis of lymphedema that may contribute to enhance the success of micro-surgery.

Eligibility criteria:
inclusion criteria: * at least 20 years of age * patients underwent preoperative and receive magnetic resonance lymphangiography and lymphoscintigraphy at the postoperative 3 months exclusion criteria: * patients with a history of adverse effects on magnetic resonance contrast agents * patients with a decreased renal function(glomerular filtration rate \<30 ml / min) * other, maternity, patients with a pacemaker or a cochlear
a comparison of two surface materials (tantalum versus titanium fiber mesh) of acetabular components in hip arthroplasty

Conditions: Osteoarthritis

Summary: the purpose of this study is to compare two surface materials (tantalum versus titanium fiber mesh) of acetabular components in hip arthroplasty.

in younger patients, acetabulum components are most often implanted without the use of cement. a direct ingrowth of bone to the implant is crucial to the attainment of good results in those cases where cement is not employed. a new implant material (tantalum) has shown better properties than the implant material which is in use today (titanium). the advantages of tantalum implants are greater porosity, reduced stiffness and a higher friction coefficient than with titanium implants. hypothetically, the higher porosity of tantalum should enhance bone ingrowth due to better osteoconductivity in terms of: 1. less migration of the acetabulum component, as evaluated by rsa; 2. increased bmd in the bone surrounding acetabulum components; 3. fewer postoperative complaints on the harris hip score and visual analog scale scores. the migration of acetabulum components will be evaluated by rsa. the follow-up rsa will be scheduled for week 1, as well as 3 months, 12 months and 2 years after surgery. bone mineral density around the implanted femoral component will be examined by dexa scan at week 1, as well as 1 year and 2 years after surgery.

Eligibility criteria:
inclusion criteria: * patients with primary arthritis in the hip. * patients with sufficient bone density to allow uncemented implantation of a femoral component. * informed patient consent in writing. exclusion criteria: * patients with neuromuscular or vascular disease in the affected leg. * patients found upon operation to be unsuited for uncemented acetabulum component. * patients who regularly take non-steroid anti-inflammatory drugs (nsaid) and cannot interrupt intake for the postoperative phase of the study. * patients with fracture sequelae. * female patients of childbearing capacity. * hip joint dysplasia. * sequelae to previous hip joint disorder in childhood.

Keywords: rsa dexa osteoarthritis hip arthroplasty
pharmacokinetics of meropenem during high-dose crrt

Conditions: Infection; Renal Failure

Summary: assessment of meropenem plasma concentration in critically ill patients who require crrt (continuous renal replacement therapy). a standard dose of meropenem is administered, i.e. 1 gram every 8 hours.

this is a prospective observational study performed on critically ill patients. inclusion criteria are a severe infection on admission requiring the use of meropenem and crrt. both medical and surgical patients will be included. any type of infections can be included (pulmonary, abdominal, urinary tract, etc.) antibiotics regimen includes one-hour infusion of meropenem (1.0 gram) intravenously every 8 hours. blood samples (2 ml) will be collected at the 15, 30, 45, 60, 75, 90, 120, 180, 240, and 480 minutes after each dose of meropenem for 3 consecutive days. the standard arterial canula will be used to obtain samples. 30 minutes after each sample collection, blood will be centrifuged for 10 minutes at 3,000 rpms. subsequently, supernatant will be collected and frozen. serum meropenem concentration will be measured by high-performance liquid chromatography. each patient's hemodynamic parameters will be recorded with the use of transpulmonary thermodilution technique (picco). other therapies, i.e. ventilatory support, sedation, an antifungal agent will be given as required.

Eligibility criteria:
inclusion criteria: * patients who require icu treatment due to severe infection * age 18-80 years * an eligible consent obtained from the patient or his/her attendant exclusion criteria: * allergy to meropenem * lack of consent to participate in the study * age of patients below 18 or above 80 years
the effect of antenatal education on fear of birth, physiological ability to give birth and traumatic birth perception

Conditions: Healthy Volunteers; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Nulliparity

Summary: today, pregnancy and childbirth are important life events that involve many challenges and changes for both men and women. during this process, changes occur in the pregnant woman's body, emotional state and family life. these changes often lead to anxiety about the health of the baby and her own health and to the creation of new stressful situations. during antenatal education, deep relaxation and breathing techniques taught to pregnant women during labour and delivery allow the mother to relax and cope with birth pains more easily and on her own. there are not enough studies in the literature to evaluate the effectiveness of online antenatal classes. in cases where face-to-face antenatal education is not possible during pregnancy, online education is an important option. in the literature, there is no study evaluating how antenatal education affects women's fear of childbirth, physiological ability to give birth and traumatic birth perception together. therefore, the aim of this study is to examine the effect of antenatal education on fear of childbirth, physiological ability to give birth and perception of traumatic birth. the type of the study is a randomised controlled experimental study with pre-post and control group. the research will be conducted in the form of online training meetings on pregnant women reached through social media. the population of the study will consist of healthy pregnant women who apply to the researchers as a result of the announcements made through social media and who are at the 20th gestational week at the earliest. the sample size was determined by t-test analysis in independent groups in g\*power statistical programme, based on two variables, 0.05 significance level, 80% power and medium effect (0.50). accordingly, a total of 42 pregnant women, 21 pregnant women in each group, are planned to be included in the study. intention-to-treat analysis will be performed to prevent bias and losses. as an intervention programme, a total of three weeks and six hours of childbirth preparation training will be given, two hours each week. the programme has been prepared by faculty members who have conducted childbirth preparation classes, based on the literature and by making use of childbirth preparation philosophies and methods.


Eligibility criteria:
inclusion criteria: * voluntary acceptance to participate in the research * being over 18 years of age * being at the 20th gestational week at the earliest. * not carrying a high risk in pregnancy * nulliparity * expected to have a normal spontaneous labour exclusion criteria: * refusal to participate in the research * failure to complete six hours of the childbirth preparation class * inability to use the zoom application * psychiatric illness

Keywords: antenatal education fear of birth physiological ability to give birth traumatic birth perception