Kornimate/medical-research-clean huggingface dataset:
intervertebral disc augmentation with minimally invasive surgical procedure

Conditions: Degenerative Disc Disease

Summary: the primary purpose of the study is to establish the degree and duration of pain relief following minimally invasive surgery for a painful degenerative disc.

the investigators will study patient recovery (outcome measures) in patients who have had minimally invasive surgery for implantation of human meniscus allograft (hma) to replace the nucleus pulposus of a degenerative intervertebral disc.

Eligibility criteria:
inclusion criteria: * diagnosis of degenerative disk disease at l3-l4, l4-l5, or l5-s1 * low back for no more that one year prior to enrollment exclusion criteria: * osteoporosis * degenerative changes of vertebral endplates (obvious fractures, osteophytes) * modic type ii changes indicative of advanced bony degeneration * facet arthrosis (loss of facet joint cartilage, increased synovial fluid collection, or presence of osteophytes in inferior or superior plates) * discs classified with stage i or ii degeneration * patients unable to have an mri (pacemaker, claustrophobia, etc.)

Keywords: l3-l4 l4-l5 l5-s1 human meniscus allograft nucleus pulposus minimally invasive surgery degeneration of l3-l4 intervertebral disc degeneration of l4-l5 intervertebral disc degeneration of l5-s1 intervertebral disc
erector spinae plane block improves organ dysfunction in septic patients with acute gastrointestinal injury

Conditions: Sepsis; Acute Gastrointestinal Injury; Organ Dysfunction Syndrome

Summary: this study is a prospective, multicenter, parallel-group, open-label, randomized controlled clinical trial. sepsis is defined as organ dysfunction induced by infections. and sepsis and gastrointestinal injury can be the leading cause for each other. our previous study showed erector spinae plane block improved the organ dysfunctions in patients with agi. the aim of the clinical trial is to investigate erector pinae plane block improves the organ dysfunction in septic patients with acute gastrointestinal injury.


Eligibility criteria:
inclusion criteria: * septic patients with acute gastrointestinal injury grade ii or iii; * age over 18 years; * expected to stay in the icu for at least 3 days or longer; exclusion criteria: * mean arterial pressure less than 65 mmhg after fluid resuscitation, or requirement for an intravenous norepinephrine dose of greater than 0.5 µg/kg/min to maintain a normal mean arterial pressure; * heart rates less than 50 beats/min, or concomitant with moderate-to-severe atrioventricular block without a pacemaker; * contraindications for erector spinae plane blocks, including infection of the puncture site, spinal diseases or immobilization; * primary gastrointestinal disorders requiring a surgical procedure, such as mechanical intestinal obstruction, massive gastrointestinal hemorrhage, and gastrointestinal perforation; * gastrointestinal operation within one week before enrollment; * neuromuscular disorders; * coagulation abnormalities：activated prothrombin time or prothrombin time is prolonged with 2 folds, or platelet count less than 50×109/l; * end-stage malignant tumor or cachexia; * history of allergy to amide anesthetics; * known pregnancy;

Keywords: sepsis acute gastrointestinal injury organ dysfunction syndrome erector spinae plane block
antimicrobial susceptibility patterns of n. gonorrhea isolates in an era of quinolone resistance

Conditions: Gonorrhea

Summary: to perform a laboratory sensitivity testing survey of antibiotic agents against neisseria gonorrhea isolates from men with symptomatic urethritis seen at an std clinic.

until recently, the fluoroquinolones (ofloxacin, ciprofloxacin, levofloxacin) have been the first line oral agents for the empiric treatment of gonorrhea. the prevalence of quinolone resistant neisseria gonorrheae (qrng) has been rising since 2000. in 2006, the cdc updated its guidelines to include recommendations against the use of quinolones for treatment of neisseria gonorrheae. ceftriaxone (available only by intravenous or intramuscular route) was named as the first line treatment for urogenital and pharyngeal disease. availability, in the united states, of the other two cdc recommended agents cefixime (oral) and spectinomycin (im) has been nonexistent. at this time, there is little data on the in-vitro (laboratory test) susceptibility of antibiotics against gonorrhea, particularly oral drugs. the purpose of this study is to collect specimens of gonorrhea in a non-invasive swab manner from men with symptomatic urethral discharges for laboratory sensitivity testing against a wide array of antibiotic agents. specific aims: to perform a laboratory sensitivity testing survey of antibiotic agents against neisseria gonorrhea isolates from men with symptomatic urethritis seen at a duval county std clinic .

Eligibility criteria:
inclusion criteria: * men between the ages of 18 to 80 years old with suspected urethral gonorrhea by symptoms or gram stained smear exclusion criteria: * patients less than 18 years old or greater than 80 years old * inability to give an informed consent

Keywords: neisseria gonorrheae antimicrobial susceptibility quinolone resistance sexually transmitted diseases
cutaneous squamous cell carcinoma staging study

Conditions: Cutaneous Squamous Cell Carcinoma

Summary: cutaneous squamous cell carcinoma (cscc) is the second most common form of skin cancer, and one of the most common cancers worldwide. the majority of csccs are easily removed by surgery and have excellent prognosis. however, a small subset has poor outcomes, including secondary spread in the body (metastasis) and death. the investigators will look at existing cscc in people from two uk dermatology centres. the investigators will then evaluate the accuracy of current staging systems in predicting risk of poor outcomes in people. the investigators hope that this project will improve the management of patients with cscc by validating the predictive power of currently available histological staging classifications for cscc. in the second stage of the study, the investigators will see whether better prediction tools can be found.


Eligibility criteria:
inclusion criteria: * over 18 years old with diagnosis of cscc exclusion criteria: * patients who decline for their data to be used for research purposes
recovery of respiratory system in covid-19 patients

Conditions: Covid19

Summary: the purpose of this study is to determine the effects of the clinical course of treatment as well as long-term symptoms of covid-19 on respiratory function, exercise capacity, and quality of life.

this study will be completed over 4 sessions at the mayo clinic at either the scottsdale arizona or rochester minnesota locations. you will be asked to complete a series of questionnaires, lung function tests, and exercise tests at two time points: ≥ 28 days post diagnosis and 4-6 months after the first laboratory visit. all visits will take approximately 2 hours. during visits 1 and 3 a series of questionnaires as well as breathing tests, and an exercise test will be completed on a stationary bike. you will also be asked to breathe a gas mixture out of a bag to obtain measures of gas movement and sensitivity. during visits 2 and 4 you will complete an exercise test on a stationary bike to measure changes from the previous exercise test and a chest scan.

Eligibility criteria:
inclusion criteria: * have a documented positive qrt-pcr for sars-cov-2 confirming prior covid-19 diagnosis * at least 18 years of age. * female subjects must not be pregnant or trying to become pregnant during the duration of study participation. * no known plans to move out of the state, or become unable to return to one of the mayo clinic sites for follow-up testing. * must be able to provide clear informed written consent. exclusion criteria: * individuals with pacemakers or other implantable devices that will make interpreting a ct scan challenging. * individuals with major limitations to exercise.
the ultrasound guided versus land-mark location method for performing spinal anesthesia in obese parturients

Conditions: Morbid Obesity

Summary: this study will be investigated whether an ultrasound-assisted technique is better than a classical land-mark technique to facilitate spinal anesthesia in the lateral position in morbidly obese pregnant women with bmi ≥ 40 who will undergo elective cesarean section. the primary objective in this study is the rate of successful dural puncture at the first attempt. it was assumed that ultrasound could facilitate neuraxial blockade in grade 3 morbidly obese pregnant women according to the who classification, whose topographic anatomy is difficult.

spinal anesthesia is the most commonly used anesthesia method for elective cesarean deliveries. anesthesiologists may have difficulties in determining the poorly palpable surface landmarks in morbidly obese pregnant women. manual palpation technique, which is preferred in neuraxial anesthesia, may be difficult in obese pregnant women due to the difficulty in identifying bone landmarks. neuraxial ultrasound examination before spinal anesthesia may help spinal anesthesia performance and decrease number of attempts in obese parturients. this study will be conducted as a single-center, prospective, randomized, double-blinded trial in a university hospital. patients scheduled for elective cesarean will be screened for enrollment in the study. patient, the anesthetist administering spinal anesthesia and evaluating the data were blind to the distribution of patient groups.ultrasonographic examinations were performed by a single investigator trained in this technique who performed more than 150 ultrasound-guided neuraxial blocks.

Eligibility criteria:
inclusion criteria: * parturient who will receive selective cesarean delivery under spinal anesthesia * asa 2-3 scheduled for elective sections * bmi≥40 kg/m2 * normal singleton pregnancy * ≥37 weeks of gestation exclusion criteria: * multiple gestations * emergency c-section * exist contraindications of spinal anesthesia * local anesthetics allergy * bmi\<40 kg/m2 * history of lumbar spinal diseases and lumbar surgery * parturient refusal

Keywords: spinal anesthesia cesarean delivery ultrasound
bmi study for children ages 6-9 years and parents

Conditions: Childhood Obesity

Summary: the purpose of this study is to test the fitwits office tool and games with 6-9 year old children and their parents to: 1) assist parent-child dyad with correct bmi status identification and understanding; 2) address nutrition, portion size, and activity cues; and, 3) track bmi trajectory over 12-month period.

the investigators will study parents' perceptions of their child's bmi before and after the fitwits intervention with a primary goal of improving parents' ability to identify their child's actual bmi status (underweight, healthy weight, overweight, or obese). secondary goals are to measure changes in behaviors and bmi trajectories with repetitive use of the fitwits office tool. the study design is a longitudinal non-randomized intervention study with four time points (baseline, 3, 6, and 12 months). the investigators will recruit family medicine residents, fellows, and faculty at the investigators' three family health centers and enroll 150 parent/guardians and children aged 6-9 years at well child visits, regardless of initial bmi. the investigators will use electronic health record-generated bmi percentages, the physician-led fitwits office tool as the intervention, and self-reported surveys for the parent-child dyad. surveys will record the bmi understanding -pre- and post-fitwits intervention at each visit. the investigators will compare the intervention to a control group residency-based family health center with usual care for child/parent dyads presenting at well child care and 12 months later. at this site the investigators will survey for correct parent identification of the child's bmi category.

Eligibility criteria:
inclusion criteria: * ages 6-9 regardless of bmi status exclusion criteria: * non-english-speaking
remote ischaemic preconditioning in transplantation (riptrans)

Conditions: Transplant Dysfunction

Summary: remote ischemic preconditioning (ripc) is a concept where remotely induced ischemia produces protection against ischemia-reperfusion injury in a remote organ. ripc has been studied extensively in animal models and heart surgery, but it's benefit in transplantation has been studied less. the primary aim of this study is to find out whether ripc performed in a donor in donation after brain-death (dbd) could improve delayed graft function rate of kidney transplants.


Eligibility criteria:
donor inclusion criteria: * brain-dead organ donor with a plan of harvesting at least one kidney donor exclusion criteria: * haemodynamically unstable donor * age below 18 years * planned organ recipients are recruited to another prospective trial, which prevents participation in this trial. all organ recipients receiving organs (kidney, liver, pancreas-kidney, heart, lungs) from a randomized donor will be recruited providing that the recipient surgery is performed at helsinki university hospital, recipient is over 18 years old, and recipient gives written informed consent to participate in the trial.
investigate the effect of azd1656 on the pharmacokinetics of digoxin in type 2 diabetes mellitus patients

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to determine whether azd1656 will affect the pharmacokinetics (pk) of digoxin in type 2 diabetes mellitus (t2dm) patients.


Eligibility criteria:
inclusion criteria: * patients with confirmed type 2 diabetes for at least 1 year and treated with metformin as a single treatment or in combination with one other oral anti diabetic for at least 2 months prior to screening. * body mass index between ≥19 and ≤42 kg/m2. * haemoglobin (hb) a1c ≥6.5% and ≤9.5% at enrolment. exclusion criteria: * history of cardiovascular disease, eg, left ventricular hypertrophy, uncontrolled hypertension, paroxysmal or persistent cardiac arrhythmia or ischemic heart disease. * systolic blood pressure \>160 mmhg or diastolic blood pressure \>95 mmhg at screening * use of amiodarone within 3 months prior to screening and the use of potent cyp450 inhibitors

Keywords: diabetes type 2 digoxin drug-drug interaction
comparing pa compliance during and after decompensation in hfp

Conditions: Congestive Heart Failure; Decompensated Heart Failure

Summary: pulmonary artery compliance measurements will be obtained with the respirix device in patients with congestive heart failure decompensation. echocardiogram, weight measurements, and bnp will also be gathered as independent measures of decompensation in the clinic. pulmonary artery compliance measurements will be made daily during the hospital stay. patients can continue using the device at home for the next 3 weeks. each patient will serve as their own control and relative changes from their baseline will be recorded for each parameter.


Eligibility criteria:
inclusion criteria: 1. patient must ≥ 18 years of age 2. patient has been diagnosed with congestive heart failure, class ii-iv 3. patient is currently being admitted for decompensation related to congestive heart failure 4. subject or subject's legally authorized representative is able to give informed consent before entering the study. exclusion criteria: 1. currently pregnant or breastfeeding 2. clinical signs or symptoms of a respiratory infection 3. unable to obtain a high-quality signal, as determined by variability of npac values throughout a single breath, within 48 hours of enrollment 4. inability to withstand a 10 second end-inspiratory pause, in the opinion of the investigator 5. deemed unsuitable for enrollment in study by the investigator based on subjects' history or physical examination
stroke recovery research based on eeg-fmri

Conditions: Motor Neuropathy

Summary: this study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from eeg-fmri data.

a group of patients with ischemic stroke and age/gender matched healthy controls would be enrolled in this study. their features of neural activities based on eeg-fmri fusion scan would be extracted to investigate the mechanisms of motor recovery after stroke. particularly, the correlations of their features of neural networks or local activities to their motor function (defined as their fugl-meyer scores) at enrollment and their recovery time courses consisted of fugl-meyer scores in follow-up time points. data of t1 structural, dsi fiber image and pure eeg (without mri) would also be collected along with eeg-fmri fusion data.

Eligibility criteria:
inclusion criteria: * age above 18 and below 75 years * motor impairment in national institutes of health stroke scale * 7-14 days since stroke attack * first-ever ischemic stroke exclusion criteria: * motor impairment induced by non-stroke aetiology * claustrophobia; recognition disorder * history of other severe central nervous system diseases * any signs unfit for mri/eeg scan

Keywords: motor function recovery ischemic stroke eeg-fmri neural plasticity
impact of severe tricuspid regurgitation correction on gut microbiota and gastrointestinal function

Conditions: Tricuspid Regurgitation (TR)

Summary: tricuspid regurgitation (tr) is gaining increasing attention within the cardiological community due to its poor prognosis, challenging clinical presentation and difficult treatment. tr causes decreased forward cardiac output and increased intravascular pressure upstream, which lead to peripheral oedema, ascites, hepatic congestion and kidney failure. the microbiota is also getting increasing attention and changes in microbiota have been already associated with cardiovascular disease. the impact of hemodynamic effects of tr on the gut microbiota however is still unknown. patients affected by tr frequently complain abdominal distension and anorexia. we hypothesize that, due to increased venous congestion, tr may induce impaired gut function with modification in the microbiota and that tr correction may induce reverse changes. this study will enroll patients treated with transcatheter tricuspid edge-to-edge repair (t-teer) at the valve center of san raffaele hospital due to severe tr. in addition to the standard of care, before t-teer, for all patients 2 additional blood samples, 1 urine and 1 fecal sample will be collected. 3 months after the procedure, all patients will be re-assessed at the valve center outpatient clinic as standard of care. at this stage for all patients 2 blood samples, 1 urine and 1 fecal sample will be collected again for the purpose of the study. the microbiota metabolites of patients after 3 months from the procedure will be compared to those at baseline according to the degrees of residual tr. to assess the reproducibility of the microbiota results and to explore an intrinsic short-term variation in microbiome composition within single patients, a subgroup of 30 patients will undergo a low intervention substudy repeating the measurements (2 blood, 1 urine and 1 fecal) within 10 days, both at baseline and at follow-up.


Eligibility criteria:
inclusion criteria: * adult patients, able to sign the informed consent form, admitted to osr heart valve center with tr ≥ severe treated with t-teer. exclusion criteria: * concomitant ≥ severe mr. such patients may be treated with m-teer and be re-evaluated after 3 months: if tr is ≥ severe and mr is ≤ moderate the patient may then be enrolled. * surgical candidates * recent \< 6 months cardiac coronary or structural procedure * cad requiring intervention * other valvular disease \> moderate * treatment with transcatheter tricuspid replacement * age \<18 years * inability or unwillingness to sign informed consent * kidney dialysis * acute infection * inflammatory bowel diseases * gastrointestinal diseases * previous gastrointestinal surgery * active cancer * active autoimmune or inflammatory diseases * treatments with antibiotics or probiotics within one month * emergency procedures * patients enrolled in interventional studies that may confound study results

Keywords: tricuspid regurgitation gut microbiota gastrointestinal heart heart valve disease tricuspid valve disease transcatheter t-teer
improving community based tuberculosis care in ethiopia

Conditions: Pulmonary Tuberculosis

Summary: the purpose of this study is to see if involving community health workers improves tuberculosis case finding and treatment outcome.

tuberculosis suspects in the study area outcome smear positive tuberculosis cases identified smear positive tuberculosis cases treated

Eligibility criteria:
inclusion criteria: * suspects of pulmonary tuberculosis exclusion criteria: * not in the study area

Keywords: tb community community health workers ethiopia identify suspects of pulmonary tuberculosis collect sputum specimen for examination treat smear positive cases in the community
a 3-month non-interventional study of asthmatics treatment with symbicort® turbuhaler®

Conditions: Asthma

Summary: the purpose of this study is to investigate real practices of treatment with symbicort turbuhaler for 3 months in asthma and patient compliance.


Eligibility criteria:
inclusion criteria: 1. provision of informed consent 2. asthmatics who has been prescribed symbicort according to physician's judgement 3. usage of symbicort should follow local prescribing information exclusion criteria: 1. not being involved in the planning and conduct of the study (applies to both astrazeneca staff or staff at the study site) 2. no previous enrolment in the present study