Kornimate/medical-research-clean huggingface dataset:
tens analgesia during outpatient urethral bulking for stress urinary incontinence.

Conditions: Stress Incontinence Female; Urinary Incontinence; Urinary Incontinence,Stress; Pain; Pain Acute

Summary: this will be a double-blind randomized control trial in women with stress urinary incontinence who are undergoing an outpatient transurethral bulking procedure for stress urinary incontinence. subjects will be identified by the university of rochester urologists and urogynecologists participating in the study who currently oversee stress incontinence care. subjects will be randomized into two groups. one group will be undergoing the cystoscopy with transcutaneous electrical nerve stimulation (tens) for analgesia, and the second group will have the cystoscopy with placebo tens.

this will be a double-blind randomized control trial in women with stress urinary incontinence who are undergoing outpatient transurethral bulking procedures. these subjects will be identified by the university of rochester urologists and urogynecologists participating in the study, who oversee the patient's stress urinary incontinence management. the subjects will be asked to participate in this research project when the doctor is offering options for their sui treatment. subjects will be randomized into two groups. one group will undergo transurethral bulking with tens for analgesia, and the second group will have the procedure performed with placebo tens. the application of the tens device will be performed by a study team member who will know to what group the patient was randomized. both groups will be given the vas, satisfaction scale, and 5-point likert scale questionnaires to be answered before, during, and after they undergo treatment on the scheduled day of the procedure. the primary outcome will be a change in the vas pain measurement. investigators hypothesized that tens used during transurethral bulking injections would result in a 10-mm decrease in vas compared to placebo tens. secondary outcomes will be: 1. a discrete 5-point likert scale to assess the internal consistency of the pain rating within the study 2. a satisfaction 10-point scale questionnaire 3. rate of side effects to the use of tens (skin irritation, pain or burning at electrode site) and transurethral bulking injections (vasovagal symptoms: dizziness, nausea, vomiting, shoulder pain, vertigo, sweating, fainting), 4. length of procedure.

Eligibility criteria:
inclusion criteria: * • women, age ≥18 years * diagnosis of sui * scheduled to undergo transurethral bulking in the office * able to read/write english exclusion criteria: * • cutaneous damage such as ulcers or broken skin on target treatment area * currently implanted cardiac pacemaker or defibrillator * pre-procedural use of opioids for pain management, less than 8 hours from last dose * participants with altered sensation below the umbilicus

Keywords: tens pain transcutaneous electrical nerve stimulation analgesia
hto with and without arthroscopy

Conditions: Medial Compartment Osteoarthritis of the Knee

Summary: it remains unknown if a concomitant arthroscopic knee debridement would increase the benefits of surgery (quality of life and functional ability) for young active patients with medial compartment oa of the knee and varus alignmen. this additional procedure has a low incidence of morbidity and would potentially allow for treatment of meniscal tears and articular damage, as well as joint lavage to remove debris and inflammatory factors. a trial is needed to determine whether hto with concomitant knee arthroscopy will result in better overall outcomes for this patient group.the objective is to compare the quality of life, functional status, pain, and swelling of patients who undergo an hto with or without a concomitant knee joint arthroscopy to address additional joint pathology

arthroscopy for degenerative conditions of the knee is among the most widely employed orthopaedic procedures, but its effectiveness (like the effectiveness of many surgical operations) has never been proven in prospective trials. the evidence supporting the use of arthroscopy in treatment algorithms for knee oa comes largely from case series and cohort studies. these studies have shown that about 50% of patients report pain relief following the procedure. predictors of poor outcome following arthroscopy include marked mal-alignment, restricted range of motion, advanced radiographic changes, and prior surgery. improved outcomes are predicted by preoperative mechanical symptoms caused by loose bodies, meniscal tears, or radiographic evidence of mild articular degeneration. the proposed study is a randomized clinical trial. each patient will undergo a preoperative mri of their affected knee joint to identify existing pathology (e.g. meniscal tears, loose bodies, chondral flaps). the results of the mri will not be revealed to physicians, patients or data collectors. this will ensure that we have information on the existing joint pathology within each group and that prognostic variables between groups were sufficiently balanced (i.e. comparable rates of similar pathology per group). the primary outcome measure is self-reported quality of life (womac). secondary measures include self-reported functional ability (lefs), swelling, pain and frequency of analgesic use (patient diary), and general health (sf-36). assessments will take place preoperatively and at 3, 6 and 12 months postoperatively.

Eligibility criteria:
inclusion criteria: * patients with medial compartment osteoarthritis as determined by clinical examination and plain radiographs. * scheduled for an hto exclusion criteria: 1. evidence of other significant knee pathology, 2. active joint or systemic infection, 3. major medical illness that would preclude undergoing surgery, 4. patients who are unwilling or unable to be assessed according to study protocol for one year following surgery 5. major psychiatric illness, developmental handicap or inability to read and understand the english language

Keywords: hto arthroscopy osteoarthritis alignement varus gonarthrosis
validating the hum test

Conditions: Hearing Loss

Summary: the sensitivity and specificity of the hum test is being investigated in it's ability to detect conductive hearing loss. the hum test is simply elicited by asking the subject to hum to him or herself for a few seconds at both a high and low pitch that is comfortable for the subject. the subject is then asked if the hum was heard on one side more than the other (left or right), or if the sound was equal on both sides. to simulate conductive hearing loss, ear plugs will be placed in one of the subject's ears. we will elicit the hum test as well as the standard weber test and audiogram across two conditions, with an ear plug and without an ear plug. from this, it is hoped to assess how the hum test compares to the audiogram (gold standard) in detecting conductive hearing loss as well as how it compares to the standard weber test. if the hum test demonstrates strong sensitivity and specificity in detecting conductive hearing loss, it could have application as being utilized as an alternative to the standard weber test, or in a setting where a formal physical examination may not yet be possible but where the etiology of a patient's hearing change could be quickly assessed remotely and thus the urgency of intervention/ consultation could then be determined.

it is presumed that the hum test works similarly to the weber test, where bone conduction of the skull is elicited to determine if a change in hearing is conductive or sensorineural in nature. because the hum test is frequently employed in clinical practice yet its validation has yet to be demonstrated, investigation is warranted. to examine and compare the hum test, weber test, and audiogram in their ability to detect and identify hearing loss, hearing loss will be simulated with the use of ear plugs (mimicking conductive hearing loss). subjects will serve as their own control as these tests will be conducted with and without ear plugs. study data will be maintained using an online, password protected storage system. no identifiable information will be collected or stored (i.e. name, dob, etc.). limited demographic information will be collected for analysis purposes such as age and gender.

Eligibility criteria:
inclusion criteria: * age 18-35 * subjective normal hearing and no previous complaints or history of hearing problems or otologic disorders * subjects will be nyu medical students, nyu resident physicians, or patients from the long island cochlear implant center exclusion criteria: * has not had a uri (assessed by asking patient if they have had fever, cough, sore throat, nasal congestion, or runny nose) within one month of study session

Keywords: hum test, weber test, audiogram
effect of finerenone in patients with non-diabetic glomerulonephritis

Conditions: Glomerulonephritis

Summary: this study aims to assess the effect of finerenone on proteinuria and gfr progression in patients with non-diabetic glomerulonephritis.

in patients with type 2 diabetes and advanced ckd, finerenone resulted in lower risks of ckd progression and cardiovascular events. mineralocorticoid receptor over activation in the kidney leads to inflammation and fibrosis with subsequent progressive kidney disease. finerenone, a nonsteroidal, selective mineralocorticoid receptor antagonist, had more potent anti-inflammatory and ant fibrotic effects than steroidal mineralocorticoid receptor antagonists. finerenone has been shown to reduce the urinary albumin-to-creatinine ratio in patients with ckd treated with an ras blocker, while having smaller effects on serum potassium levels than spironolactone. glomerulonephritis (gn) is an inflammation affecting kidney glomeruli, and is considered an important cause of ckd. reducing proteinuria is one of the main therapeutic targets in patients with gn.

Eligibility criteria:
inclusion criteria: 1. gn patients on maximum tolerated doses of an acei or arbs together with their immunosuppression protocol (if needed) for at least 4 weeks. 2. urinary protein excretion \>500 mg/g. 3. adult patients with age above 18 years. 4. egfr ≥ 25 ml/ min/1.73 m2. 5. baseline serum potassium level \<5 meq/l. exclusion criteria: 1. patients with diabetes mellitus (type 1 or 2). 2. other non-glomerular kidney diseases. 3. heart failure. 4. breast feeding or pregnancy. 5. patients who received medications to treat hyperkalemia 4 weeks before study. 6. uncontrolled hypertension (bp \> 160/100).

Keywords: finerenone proteinuria gfr progression glomerulonephritis
adenoma miss rate with water exchange vs carbon dioxide colonoscopy

Conditions: Colonic Adenoma; Water Exchange Colonoscopy

Summary: this was an observational study comparing consecutive group of we and co2 insufflation in terms of right and proximal colon amr by tandem colonoscopy.

this was a prospective observational study to assess how we colonoscopy would fit into clinical and research practices. we first observed whether optimal we colonoscopy decreased the amr in the right and proximal colon in a tandem approach. if we did lower the amr as compared with data in the literature, a randomized rct deserves to be studied. for the calculation of sample size in the upcoming rct, the amr in the co2 group would be collected. the differences of the amrs in the right and proximal colon determined by tandem colonoscopy using we or co2 insufflation would then be compared.

Eligibility criteria:
inclusion criteria: * consecutive patients aged 20 years or older undergoing colonoscopy for screening and surveillance indications were considered for enrollment. exclusion criteria: * familial adenomatous polyposis and hereditary non-polyposis crc syndrome, personal history of inflammatory bowel disease, previous colonic resection, inability to achieve cecal intubation, obstructive lesions of the colon, poor colon preparation, inability to completely remove a polyp, gastrointestinal bleeding, allergy to fentanyl or midazolam, american society of anesthesiology classification of physical status grade 3 or higher, mental retardation, pregnancy, and refusal to provide a written informed consent.

Keywords: adenoma miss rate adenoma detection rate
aml cell immunotherapy using chimeric antigen receptor t-cells

Conditions: Acute Myeloid Leukemia

Summary: aml is one of the most aggressive forms of leukemia, where bone marrow transplantation remains the gold standard treatment, with its known associated toxicities and related mortality. despite progress in the treatment of leukemic malignancies, especially the emergence of targeted- and immuno-therapies arising from biological genomic knowledge, there remains a need to provide additional strategies for refractory/relapsing (r/r) patients aim of this study is to collect biological samples of aml patients in order to validate our chimeric antigen receptor t-cells immunotherapy approach


Eligibility criteria:
inclusion criteria: * aml patients adults and pediatrics exclusion criteria: * aml3

Keywords: aml chimeric antigen receptor t cells immunotherapy
study of tru-015 in subjects with membranous nephropathy secondary to systemic lupus erythematosus

Conditions: Systemic Lupus Erythematosus

Summary: the purpose of this study is to determine how the body absorbs and chemically changes a single infusion of tru-015 in subjects with kidney disease caused by lupus.


Eligibility criteria:
inclusion criteria: * man or nonlactating and nonpregnant woman, aged 18 to 70 years, inclusive, at the screening visit. * diagnosis of systemic lupus erythematosus more than 6 months before study day 1. * history of positive antinuclear antibody titer of \>1:160 or equivalent. * biopsy-proven class v lupus nephritis within the last 2 years. * have been on a stable dose of oral corticosteroids (\<20 mg/day prednisone or equivalent) for 2 months before study day 1.

Keywords: membranous nephropathy systemic lupus erythematosus
chidamide combines with vp-16 and methylprednisolone in the treatment of hlh

Conditions: Chidamide; Hemophagocytic Lymphohistiocytosis

Summary: chidamide combines with vp-16 and methylprednisolone in hlh

this study aimed to investigate the efficacy and safety of chidamide together with etoposide and methylprednisolone for hemophagocytic lymphohistiocytosis

Eligibility criteria:
inclusion criteria:meet hemophagocytic lymphohistiocytosis (hlh)-04 diagnostic criteria; patients were diagnosed with ebv associated hlh (ebv-hlh) and lymphoma associated hlh.age ≥18 years old, gender is not limited. serum creatinine ≤ 1.5 times normal；nt-probnp ≤ normal；informed consent obtained. - exclusion criteria: active bleeding of the internal organs or patients with new thrombotic diseases；allergic to chidamide and etoposide；participate in other clinical research at the same time；hiv , hbv and hcv infected patients (hiv antibody positive)；history of qt interval prolongation, atrioventricular block, ventricular tachycardia, coronary atherosclerotic heart disease；pregnant or lactating women and patients of childbearing age who refuse to take appropriate contraceptive measures during this trial. if the patient was male, he refused to use adequate contraceptive methods or donate semen during the study period and within 3 months after receiving the last cycle of drug study；patients judged by the investigator to be unsuitable to participate in this study. -
characteristics and outcome of coronavirus disease 2019 (covid-19) in egypt

Conditions: Characteristics Diseases; Outcome, Fatal

Summary: the world health organization (who) has recently declared coronavirus disease 2019 (covid-19) a public health emergency of international concern. egypt is one of the countries that has been infected by covid-19. the characteristics of clinical presentation, laboratory and radiological data are not yet studied. outcomes of covid-19 in egypt also have not been described yet.

patients admitted to assiut university hospital, al rajhi liver hospital and other covid-19 quarantine hospitals will be included. the characteristics of patients will be described such as demographic data; age, sex,history of contact to covid-19 patients or traveling abroad and their clinical manifestation such as fever,cough,shortness of breath, sore throat, diarrhea. laboratory data will also be included such as blood picture,d-dimer, serum ferritin, creatinine, liver enzymes, oxygen saturation and covid-19 polymerase chain reaction (pcr). radiological data will be described as regarding chest x-ray and/or computed tomography. patients will be followed until complications, improvement, transfer to another hospital or death and their outcome will be described.

Eligibility criteria:
inclusion criteria: * patients with diagnosis of covid-19 . exclusion criteria: * patients refuse to participate in the study

Keywords: covid-19 characteristics outcome egypt
evaluation of gait performance in children with neuromuscular diagnoses

Conditions: Psychometrics of Two Translated Measurement Tools

Summary: the aims of this project are to evaluate the psychometric properties of the german versions of the two performance questionnaires 'functional mobility scale' (fms) and 'gillette functional assessment questionnaire - walking scale' (gfaq) in children between 6-18 years with a neuromuscular diagnosis.

the german versions of the two questionnaires 'functional mobility scale' (fms) and 'gillette functional assessment questionnaire - walking scale' (gfaq) are evaluated in terms of construct validity, inter- and intra-rater reliability as well as responsiveness in children with a neuromuscular diagnosis, who absolve an inpatient stay in the rehabilitation center of the university chilren's hospital zurich, switzerland.

Eligibility criteria:
inclusion criteria: * neuromuscular diagnosis * age: 6-18 years * rehabilitation goal = improvement of walking abilities exclusion criteria: * children's whose parents are not german-speaking

Keywords: outcome assessment gait neuromuscular diseases psychometrics clinical assessment tools
effect of virtual video reality gaming on fine motor skills in children with down's syndrome

Conditions: Down's Syndrome; Fine Motor Skills

Summary: down's syndrome is genetic disorder caused by trisomy 21. children with down's syndrome are characterized by awkward movements, gait, increased flexibility of joints, timing of mastering of basic skills, under development of fine motor skills. virtual reality therapy (vrt) is a technique that uses interactive games as a physical therapy resource and has shown positive results in cortical reorganization, improving functional mobility, and quality of movement. this is an experimental study in which randomized controlled trials study design is being used.

down's syndrome is a genetic disorder caused by trisomy 21. down's syndrome is characterized by a variety of dysmorphic features, congenital malformations and other health problems and medical conditions. not all of them are present in each affected individual. the impact of down's syndrome for each person is variable some are more affected, some are mild affected and some are fully independent.children with down's syndrome are characterized by awkward movements, gait, increased flexibility of joints, timing of mastering of basic skills, under development of fine motor skills. virtual video gaming is a best method for development of fine motor skills in down's syndrome children. virtual reality therapy (vrt) is a technique that uses interactive games as a physical therapy resource and has shown positive results in cortical reorganization, improving functional mobility, and quality of movement. this is an experimental study in which randomized controlled trials study design is being used. data will be collected from rising sun institute within 6 months after the approval of synopsis. randomized sampling method will be used. sample size will be 16 children with down's syndrome. one group is control group (self-help skills) in which only self-help skills effect on fine motor skills in down's syndrome children will be assessed. other group is experimental group (virtual video gaming) in which effect of virtual video gaming on fine motor skills will be assessed. abilhand-kids tool will be used for measurement of effectiveness of virtual video gaming in children with down' s syndrome. the objective of study is to determine the effects of virtual reality video gaming on fine motor skills in children with down' s syndrome.

Eligibility criteria:
inclusion criteria: * age group of patients ranged between 6 years to 10years. * both the gender will be considered. * subject who is able to follow the instruct exclusion criteria: * patients with medical co-morbid. * gross deformity of upper /lower limb * epilepsy

Keywords: fine motor skills down's syndrome self- help skills computer game
trial to define the benefits and harms of deceased donor kidney procurement biopsies

Conditions: Kidney Transplant; Renal Transplant

Summary: the purpose of this research study is to compare the impact of the availability of biopsy results at the time of organ offers on the use and outcomes of kidneys from deceased donors.

randomization of biopsy processing will be performed at the level of the deceased donor. if the participant agrees to be in this study and signs the informed consent, at the time that a kidney is accepted for them, the accepted deceased donor will be randomized, like a flip of a coin, to one of two groups. * group 1: biopsies will be processed immediately (routine "frozen section") and results will be available to clinical teams at the time of the organ offers. frozen section refers to a process where tissue from the biopsy sample is prepared by freezing and then slicing the tissue sample. importantly, it can be done in about 15 to 20 minutes. frozen sections are done when an immediate answer is needed; however, the quality of the sample is not always optimal. * group 2: biopsies will be processed using "permanent sections" - these results will not be available until after the organ is transplanted. permanent section refers to a process where tissue from the biopsy sample is prepared by placing the tissue sample in a fixative, called formalin, to preserve the tissue, processing it through other additional solutions, and then placing it in paraffin wax. after the wax hardens, the tissue is cut into very thin slices, which are placed on slides and stained. this process normally takes several days. there is a 50/50 chance that the donor will be randomized to immediate biopsy processing by frozen section, versus permanent processing that yields results after transplant. if for any reason their surgeon feels that it would not be safe to proceed without the biopsy result, he or she will have the ability to receive the results of the biopsy before the transplant. the study team will record any episodes of this occurrence.

Eligibility criteria:
inclusion criteria: * kidney transplant candidate * on waitlist for kidney transplant at the time of informed consent at one of the participating sites * age 18 or older * willing and able to provide informed consent for participation in the study exclusion criteria: * unable or unwilling to provide informed consent to participate in the study * younger than 18 years old * not on waitlist for kidney transplant at the time of informed consent at one of the participating centers * candidates for or recipients of multi-organ transplants (kidney along with another solid organ)

Keywords: biopsy deceased kidney donation kidney transplantation