Kornimate/medical-research-clean huggingface dataset:
metabolic, physical responses to exercise in patients with type 2 diabetes mellitus

Conditions: Type2 Diabetes Mellitus; Exercise

Summary: the aim of this study is to compare the effects of high intensity interval exercise and moderate intensity continuous exercise on metabolic parameters, physical measures, fitness level, body composition and mirna-143 level in patients with type 2 diabetes mellitus.

volunteers with type 2 diabetes mellitus will be evaluated in terms of any contra-indication that will restrain them from making exercise. 90 male or female volunteers who are suitable in terms of inclusion/exclusion criteria will be invited for the study. volunteers will be randomly distributed to one of the 3 groups. each group will contain 30 participants. 1. group will make aerobic exercise which is in the form of high intensity interval exercise 2.group will make aerobic exercise which is in the form of moderate intensity continuous exercise 3. control group. exercise groups will be cycling under observation in the hospital setting. control group will make simple stretching exercises at home. participants will be requested to complete a 3 months of exercise. they will be evaluated before and at the end of the 3 months of exercise with physical measures such as waist and hip circumference, fitness level measured by exercise testing, body composition measured by bioimpedance, metabolic parameters such as blood glucose level, hba1c and measured by blood tests.

Eligibility criteria:
inclusion criteria: 1. participants must have type 2 diabetes mellitus less than 10 years and more than 1 year. 2. participants must have appropriate medical therapy and diet. 3. participants must not be treated with insulin. 4. participants must be exercising less than 210 minutes/ week. exclusion criteria: 1. participants with prominent cardiovascular disease 2. participants with coronary artery disease 3. participants with moderate to severe valvular disease 4. participants with atrial fibrillation 5. participants with untreated hypertension 6. participants with congenital heart disease 7. participants with retinopathy 8. participants with neuropathy 9. participants with macro albuminuria 10. participants with cerebrovascular disease 11. participants with ejection fraction less than 40 12. participants with body mass index greater than 35. 13. participants with prominent ischemic changes in ekg at rest or during exercise. 14. participants with cigarette or alcohol addiction 15. participants on drugs that interferes with body fat distribution (such as insulin, thiazolidinediones)

Keywords: type 2 diabetes mellitus exercise aerobic interval continuous
cutaneous sensory block area of the laparoscopic assisted transversus abdominis plane block

Conditions: Cholecystolithiasis

Summary: the goal of this observational study is to assess the size and location of cutaneous sensory block area after dual laparoscopic assisted transverse abdominis plane block (l-tap) with ropivacaine in patients undergoing laparoscopic cholecystectomy. l-tap is applied as a medial subcostal infiltration between midclavicular and central sternal lines and a lateral subcostal infiltration between midclavicular and anterior axillary line bilaterally.


Eligibility criteria:
inclusion criteria: * undergoing elective laparoscopic cholecystectomy in a day surgery setting * able to give oral and written consent exclusion criteria: * prior surgery to the upper abdominal wall * known sensory deficits of the abdominal wall or thorax * allergy to local anesthetics * pregnancy

Keywords: transversus abdominis plane block
femoral and epidural block after total knee arthroplasty

Conditions: Acute Postoperative Pain; Chronic Postoperative Pain

Summary: total knee prosthetic replacement causes severe postoperative pain. various analgesic techniques have been used in pain control. comparison of epidural and femoral nerve block is lacking, furthermore effect on chronic pain is unclear. the investigators aimed to compare the effects of epidural and femoral block on acute and chronic postoperative pain.

background and aim total knee prosthetic replacement causes severe postoperative pain. various analgesic techniques have been used in pain control. comparison of epidural and femoral nerve block is lacking, furthermore effect on chronic pain is unclear. the investigators aimed to compare the effects of epidural and femoral block on acute and chronic postoperative pain. methods the study was of randomized, prospective, and double-blind design and was conducted with 80 patients who had undergone total knee prosthetic replacement surgery with the insertion of a femoral nerve block or epidural block catheter to initiate postoperative analgesia. one-sided spinal anesthesia was performed in all the patients. postoperative pain control was achieved with the administration via catheter using bupivacaine for patient-controlled analgesia. acute postoperative pain was evaluated in the first 24 hours and chronic postoperative pain in the 1st and 3rd months following surgery. the anxiety/depression scale was used to assess anxiety and depression, the sf 12 test was used to evaluate quality of life, and the dn4 test was employed at patient visits at the 1st and 3rd months.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of total knee arthroplasty exclusion criteria: * patients with pain syndromes * patients using routinely medications for pain

Keywords: chronic postoperative pain total knee arthroplasty femoral block we aimed to compare the effects of epidural and femoral block on acute and chronic postoperative pain.
the clinical impact of selecting acrosome reacted spermatozoa for icsi

Conditions: Infertility

Summary: presently spermatozoa for icsi are selected based on morphology and motion, without determining if acrosome reaction (ar) had occurred during sperm preparation or not. although not critical if the sperm is injected into the ooplasm, the occurrence of ar might might be an indicator of better spermatozoon quality and implantation potential, especially in severe ota cases. it is impossible with conventional plain optic microscopy used in ivf units to determine in vivo (without fixation) if ar has occurred, and as a result spermatozoa are injected randomly. it is readily possible to distinguish ar+ from ar- spermatozoa using polarized light microscopy due to different bifriengance. in this study the investigators seek to determine, by a prospective rct, if selecting only acrosome reacted spermatozoa, in severe ota cases, will improve the outcome of icsi and the entire ivf process.

a prospective rct to determine the effect of polscope based spermatozoa selection for icsi.

Eligibility criteria:
inclusion criteria: * female: normal uterine cavity and ovarian reserve. male: tmc \< 1000000 cells. exclusion criteria: * female: abnormal uterine anatomy, low ovarian reserve, contributing egg factor, pgd.
the effect of a meal on brain activation in reward pathways

Conditions: Brain Response to Visual Food Cues

Summary: scientists have studied how fasting and nutrients affect brain function in animals. the purpose of this study is to look at the effects of both fasting and food intake on brain function and memory in humans. to do this the investigators will use functional mri to observe the brain and its function while fasting and after a meal. understanding the action of these hormones in the brain may eventually lead to new ways to help people avoid obesity or lose weight.

potential subjects will participate in a short phone screening interview and if eligible, will come to the university of washington hospital 2 times. at the first health screening visit, we will go over the subjects' medical history, weight and height, and eating habits. this visit will take an hour or so and eligible subjects will then schedule the study visit. for the study visit, subjects will have to fast overnight from 9:30 pm the night before and arrive at the hospital at 8:00am. at 8:30 am, the subject will have a 30 minute mri scan of the brain done in the university of washington radiology department. during the mri scan they will see pictures of common objects and foods and be asked to remember the photos they saw. at 9 am subjects will eat a standard breakfast, and they will not eat again until after the second mri. the time of their second mri will be randomly assigned to one of seven time points anywhere from 15 minutes to 5 hours after the breakfast. after the mri, subjects will be allowed to eat freely from food we provide. subjects will receive $10 for the health screening visit, and $50-85 depending on the length of the visit.

Eligibility criteria:
inclusion criteria: 1. age 18-50 2. body mass index (bmi) 18.5-24.9 kg/m2 * age and weight are restricted because of known changes in appetite and satiety with aging and changes in body weight. exclusion criteria: 1. current dieting for weight loss or restrained eating 2. history of eating disorders, prior obesity, or weight loss surgery 3. chronic health conditions, including diabetes 4. use of medications that alter appetite (e.g., atypical anti-psychotics) 5. pregnancy or use of oral contraceptives of estrogen replacement 6. participation in other studies that might affect appetite or body weight 7. recreational drug use or alcohol use of \>2 drinks per day 8. food allergies to study foods or inability to taste 9. current smoker 10. any contraindications to mri such as implanted metal of claustrophobia * current dieting, restrained eating, eating disorders, prior weight loss surgery, diabetes, chronic disease (e.g., cardiovascular disease, cancer), and estrogen use are restricted or excluded due to documented influences on the hormones of interest. smokers and regular alcohol users are excluded consistent with prior studies of appetite regulation.

Keywords: obesity
point of care sti testing

Conditions: Point of Care STI Testing

Summary: the proposed research hypothesizes that point-of-care testing (poct) for sexually transmitted infections (stis) gonorrhea and chlamydia will be a feasible, acceptable, and appropriate implementation strategy for improving hiv testing and pre-exposure prophylaxis (prep) delivery in youth, by increasing opportunities for clinician-patient counseling, decreasing loss to follow up, and allowing for same-day hiv prevention service provision. this hypothesis will be tested in a pragmatic non-randomized trial comparing clinical (hiv testing and prep counseling and prescription) and implementation (feasibility, acceptability, and appropriateness) outcomes between adolescents receiving poct compared to laboratory-based testing at three clinics within a large pediatric health system.


Eligibility criteria:
inclusion criteria: - patients age 16-24 years receiving poct or lab-based gc/ct testing exclusion criteria: - patients with known hiv or active prep prescriptions.

Keywords: hiv prevention hiv testing hiv pre-exposure prophylaxis gonorrhea chlamydia sexually transmitted infections
barrow nasal inventory survey

Conditions: Pituitary Tumors

Summary: the purpose of this study is to evaluate patient nasal outcome following endo-nasal surgery. this type of surgery is conducted for pituitary and skull base tumors. there is no published data on trauma to the nose during surgery and how it impacts nasal functioning. the investigators propose to develop a survey and administer it to patients before and after surgery to learn about their perception of nasal functioning.

a 9-item patient survey (the ask nasal inventory) focusing on the most common postoperative complaints, such as crusting, sinusitis, pain, and ease of breathing, was developed by the anterior skull base team at the barrow neurological institute. content was validated in structured patient interviews by four subject-matter experts with both endonasal and control groups. eligible patients for the control group included patients undergoing any neurosurgical procedure requiring anesthesia that did not involve the endonasal corridor, such as spinal decompression procedures, craniotomies for trigeminal neuralgia, and shunting procedures. this survey was self-administered pre- and 3 months post-surgery.

Eligibility criteria:
inclusion criteria: * adults with planned endonasal surgery for pituitary tumor or skull base lesion exclusion criteria: * children
active communities - adherence to physical activity

Conditions: Diabetes Mellitus, Type 2; Cardiovascular Diseases; Obese

Summary: the primary aim of this study is to investigate whether a number of co-created bridge-building activities between municipality-based lifestyle programs and community-based physical activities (e.g. local sports and exercise associations) can support persons with type 2 diabetes, cardiovascular disease and/or obesity in maintain physical activity levels.

this study is an evaluation of a number of co-created bridge-building activities between municipality-based lifestyle programs and community-based physical activities. persons with type 2 diabetes, cardiovascular disease and/or obesity initiating a lifestyle program (8-12 weeks duration) in the municipality of odsherred, denmark, will be included in the study. we will include sixty (n=60) persons or the number of persons recruited at the end of the recruitment period, december 1, 2022 - whichever is reached first. participants will undergo objective measurement of physical activity level, test of standing balance, 6-minute walk test, measurement of body composition, and answer questionnaires related to their background (education, job situation, civil status), health, lifestyle and well-being. measurements will be performed before and after participants undergo a lifestyle program, and 3 and 6 months after termination of the lifestyle program.

Eligibility criteria:
inclusion criteria: * citizens in the municipality of odsherred undergoing a municipality-based lifestyle program * obese, or diagnosed with type 2 diabetes or cardiovascular disease exclusion criteria: * reliant on a wheelchair
clinical trial to evaluate the efficacy and safety of oc-01 (varenicline) nasal spray on signs and symptoms of dry eye disease

Conditions: Dry Eye Disease

Summary: the objective of this study is to evaluate the safety and effectiveness of oc-01 (varenicline solution) nasal spray as compared to placebo (vehicle) on signs and symptoms of dry eye disease.


Eligibility criteria:
inclusion criteria: * have used and/or desired to use an artificial tear substitute for dry eye symptoms within 6 months prior to the screening visit exclusion criteria: * have had any intraocular surgery (such as cataract surgery) or extraocular surgery in either eye within three months or refractive surgery (e.g., laser-assisted in-situ keratomileusis, laser epithelial keratomileusis, photorefractive keratectomy or corneal implant) within 12 months of the screening visit * have a history or presence of any ocular disorder or condition in either eye that would, in the opinion of the investigator, likely interfere with the interpretation of the study results or participant safety such as significant corneal or conjunctival scarring; pterygium or nodular pinguecula; current ocular infection, acute conjunctivitis, or inflammation not associated with dry eye; anterior (epithelial) basement membrane corneal dystrophy or other clinically significant corneal dystrophy or degeneration; ocular herpetic infection; evidence of keratoconus; etc. blepharitis not requiring treatment and mild meibomian gland disease that are typically associated with ded are allowed. * have a systemic condition or disease not stabilized or judged by the investigator to be incompatible with participation in the study (e.g., current systemic infection, uncontrolled autoimmune disease, uncontrolled immunodeficiency disease, history of myocardial infarction or heart disease, etc.) * have a known hypersensitivity to any of the procedural agents or investigational product components * have any condition or history that, in the opinion of the investigator, may interfere with study compliance, outcome measures, safety parameters, and/or the general medical condition of the subject.

Keywords: oc-01 dry eye disease
does a brief intervention decrease patient drop out rates?

Conditions: Infertility

Summary: the goal of this study is to determine a) if a follow-up email to selected patients who had an initial consult with an infertility specialist, but did not return for a second visit, would change return to care behavior and b) why patients had not returned.

from july 2017 to march 2018 all patients who had attended an initial visit with an infertility specialist at the clinic, but had not returned for at least three months were selected to receive a follow up email. those selected for an email excluded patients who the investigator's knew had achieved a pregnancy, already had a plan for treatment, had visited for an egg freeze and all lgtbq patients. the email asked if the patient had any questions about that visit, offered support to the patient and included contact information for the patient liaison sending the email. the email also asked each participant to indicate why they had not returned and were provided 4 options and an opportunity to write in a response. from april 2018 to december 2018 no emails were sent to patients. no other change of patient contact practice was initiated during the trial period. this study will observe routine to care behavior of these patients after 11 months post initial consult date.

Eligibility criteria:
inclusion criteria: * female patients attending an initial consult with a physician at boston ivf and were recommended to continue care with the clinic exclusion criteria: * patients who the investigators knew had achieved a pregnancy * patients who already had a plan for treatment in place after their initial consult * patients who had visited for an egg freeze * lgtbq patients

Keywords: infertility ivf patient retention
short daily hemodialysis and online hdf: which one is better?

Conditions: End Stage Renal Disease

Summary: 1. to compare the efficacy of 1. short daily hemodialysis 2. online hdf in term of adequacy of dialysis.

the investigators intend to compare the efficacy between these modalities of treatment in terms of adequacy and also other parameters such as calcium-phosphorus balance and hematocrit

Eligibility criteria:
inclusion criteria: * stable esrd * kt/v \> 1.2 for thrice weekly or \> 1.8 for twice weekly exclusion criteria: * inadequate vascular access flow rate * concurrent medical illnesses * history of non-compliance
beneficial effects of korean traditional diets in subjects with hypertension and type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: this trial is being conducted to look for following changes when korean traditional diets is taken in subjects with hypertension and type 2 diabetes: to evaluate the improvement of the controlling fasting blood glucose and glycated hemoglobin. to assess the controlling blood pressure and heart rate. to evaluate the influence on cardiovascular risk factor, triglyceride, cholesterol, high density lipoprotein-cholesterol and low-density lipoprotein-cholesterol. to evaluate the influence on gamma-glutamyl transpeptidase. to evaluate the influence on cardiovascular risk factor. to evaluate the influence on valsava score, breathing score and upright score.

the investigators aimed to investigate the efficacy of korean traditional diets in controlling fasting blood glucose fluctuation, blood pressure, and cardiovascular risk factors in hypertensive and type 2 diabetic patients who were taking medications prescribed for respective diseases in a 12-week.

Eligibility criteria:
inclusion criteria: * subjects who are men and women volunteers 19\~80years * subject who have hypertension and type 2diabetes. * subject who have taking oral medications : (hypoglycemic, blood pressure and lipid modifying drugs). * subject must provide written informed consent to participate in the study. exclusion criteria: * subject with a history or evidence of clinically significant gastrointestinal,anorectal, hepatic, renal, neurological, pulmonary, endocrine, blood tumor,psychiatric. * hypertension(dbp\>116mmhg or sbp\>200 mmhg) having the history of cardiovascular events or taking medications known to affect lipoprotein metabolism. * having type 1 diabetes mellitus or uncontrolled type 2 diabetes mellitus (hba1c \>9.0%). * subjects with the history of cancer. * subjects who have a gastrointestinal (gi) disease (crohn's disease, etc.) that would increase the influence with absorbance medication or a gi surgery excluding appendectomy and hernia surgery. * having digestive, or central nervous system disorders. * subject is hematologic, or neuroretinopathy. * subject with uterine fibroids at ultrasonography. * having severe or malignant retinopathy. * having the impairment of renal and liver function, dysproteinemia, nephritic syndrome, or other renal disease. * having coagulopathy * having human immunodeficiency virus. * having the history of mental instability and of drug and alcohol. * having the history of reactions to our experimental products. * participating in other clinical trials within the past 2 months. * having laboratory tests, medical or psychological conditions deemed by the investigators to interfere with successful participation in the study. * having the history of alcohol or substance abuse. * subject is pregnant, planning to become pregnant, or breast-feeding.

Keywords: korean traditional diets hypertension diabetes
the effects of a novel lifestyle intervention program on insulin sensitivity in type 2 diabetes

Conditions: Type 2 Diabetes; Fatty Liver, Nonalcoholic

Summary: moderate weight reduction by a moderately hypocaloric very-low-fat diet resulted in normalization of fasting hyperglycemia and reversal of hepatic insulin resistance in patients with poorly controlled type 2 diabetes. the diabetes remission clinical trial (direct) revealed that utilizing a total diet replacement by a low-energy formula diet for 3 months led to a 15 kg or more weight loss in 24% participants and diabetes remission 46% of the participants. to date it remains unknown whether similar results can be achieved with a natural, non-formula based diet in connection with an educative smartphone application and telephone coaching

24 patients with type 2 diabetes from the german diabetes study (gds) with less than 4 years disease duration and not receiving insulin were included in this study. before the start of the intervention, participants documented their dietary intake by recording a food diary. during the 12-week intervention participants were asked to adhere to a real food-based low-calorie diet supported by an app-guided digital education program as well as a low-calorie recipe book and received weekly coaching calls by nutritionists. patients were instructed to adhere to a balanced low calorie diet during the intervention. nutritionists provided structured behavior change focusing on dietary advice, adherence to logging dietary intake and tracking weight. at first visit, patients installed the changing health app (changing health, newcastle, uk) and completed an app-based digital education program. this program focused on type 2 diabetes education and behavioral change in combination with weight tracking and dietary monitoring. patients used the app throughout the study and adherence was monitored via logins. comprehensive testing before and after the intervention comprised a mixed-meal tolerance test and liver fat.

Eligibility criteria:
inclusion criteria: * age between 18 and 65 years * existing diagnosis of type 2 diabetes * individuals who use a smartphone or pc to install the app * individuals who are able to communicate in german exclusion criteria: * physical disability that leads to a significant lack of mobility (wheelchair, walking aid, walking stick, cane or crutches) * insulin therapy