Kornimate/medical-research-clean huggingface dataset:
effect of rosuvastatin on left ventricular remodeling

Conditions: Dilated Cardiomyopathy

Summary: the purpose of this study is to examine the the effect of the hmg-coa reductase inhibitor rosuvastatin on left ventricular remodeling in patients with dilated cardiomyopathy.

* chronic heart failure (hf) is one of the most important public health problems in cardiovascular medicine. * idioatic dilated cardiomyopathy (cmp) represents the final common expression of primary myocardial damage produced by a variety of as yet undefined myocardial insults, producing areas of interstitial and perivascular fibrosis, particularly of the left ventricle. chronic hf, including cmp, is a progressive disease with high morbidity and mortality, suggesting that important pathogenic mechanisms remain active and unmodified by the present treatment modalities. the presence of chronic inflammation in patients with chronic heart failure has been widely recognized and coupled with persistent immune activation may represent such unmodified mechanisms. the effect of statin therapy on lipids are well known, but recent studies suggest that the beneficial effects of statins also may be related to their anti-inflammatory properties. to further elucidate this issue we want to study the potent new statin rosuvastatin on myocardial function and remodeling and their relation to inflammatory markers in patients with idcm. as hyperlipidemia is not involved in the pathogenesis of idcm, as opposed to hf secondary to cad, such studies will also be an interesting approach in separating the lipid lowering from other effects of these medications in hf.

Eligibility criteria:
inclusion criteria: * age of 18-80 years * have clinical or symptomatic evidence of hf, in nyha class ii-iv, for at least 3 months * have lvef \<40% * on optimal medical treatment and considered unsuitable for surgical intervention. * have given written informed consent * no planned heart transplantation * female of potential childbearing age must have a negative serum pregnancy test within 7 days prior to enrollment. effective contraception must be used during the trial and for 6 weeks following discontinuation of the study medication, even where there has been a history of infertility. exclusion criteria: * evidence of unstable disease * evidence of ischemic etiology on the basis of history (diagnosed myocardial infarction), echocardiography or angiography) * evidence of clinical significant valvular disease based on echocardiography * significant concomitant diseases such as infections, pulmonary disease or connective tissue disease. * contraindication against statin therapy * hypersensitivity against statins * liver disease with sgot and sgpt \> 2 timer upper normal limit * baseline elevations of ck 3 times upper normal values at any time during the course of the study * serum creatinine above 2.0 mg/dl (177 umol/l) at any time during the course of the study * pregnancy or breast feeding

Keywords: heart failure inflammation cytokines
bleeding risk evaluation in haemophilia patients under antiplatelet therapies

Conditions: Hemophilia

Summary: life expectancy of haemophilia patients (specially severe) has dramatically increase in the last decades, which lead to the apparition of aging diseases such as cardiovascular disease, with the potential bleeding risk of antiplatelet therapies and anticoagulants. the primary endpoint of the study is to evaluate this bleeding risk in haemophilia patients (all severity) with such treatment in comparison to non treated patients, according to the number of bleeding events in the last year reported by the haemophilia patients under study treatment (antiplatelet and anticoagulant) in comparison to haemophilia patients free of such treatment. the main hypothesis is that antiplatelet and anticoagulant therapy can be safely used in minor haemophilia patients but might lead to increase bleeding risk in other haemophilia patients. secondary endpoint consist in: * evaluate the impact of know cardio-vascular risk in haemophilia patients (odd ratios=or) * evaluate the number of sever bleeding event in patient under study treatments compared to the control group * evaluate the overall consumption of factor viii or ix supply in patients under study treatments compared to control group * estimate the stenosis relapse risk in haemophilia patients with arterial stent * estimate the embolic risk of haemophilia patients with atrial fibrillation population description: haemophilia patients (man, all severity) age above 50 years, followed during the last 5 years in one of the study centre


Eligibility criteria:
inclusion criteria: * male * age above 50 years * hemophilia a or b carriers * followed within the 5 last years in one of the research center exclusion criteria: * jurisdictional prevention procedures * other medical condition that might interfere with the bleeding risk (willebrand's disease, other coagulation factor deficiencies, haematological malignancies, ...) * other drugs that might interfere with the bleeding risk (serotonin reuptake inhibitors) * patient refusal

Keywords: haemophilia atherosclerosis atrial fibrillation antiplatelets anticoagulant
y402h comlement factor h polymorphism and age-related macular degeneration in the austrian population

Conditions: Age-Related Macular Degeneration

Summary: the aim of the study is to show a higher expression of the y402h polymorphism in the complement factor h in patients with amd compared to healthy individuals. additionaly a correlation between a subsided infection with chlamydia and patients with amd and a factor h polymorphism will be investigated. an interrelationship with the vegf-plasma level shall give more hints into the pathomechanism of amd.


Eligibility criteria:
inclusion criteria: * man and women over 18 years old * filled out informed consentbereitschaft zur teilnahme * diagnosis of non-exudative/ exudative age related macular dgeneneration exclusion criteria: * inherited retinal diseases * other aquired retinal/ macular * missing informed consent

Keywords: age-related macular degeneration, genetics
online survey: oncologists' thoughts regarding their patients

Conditions: Oncology

Summary: our study is a questionnaire targeting the medical staff in oncology. it aims at exploring the thoughts and expectations of the medical staff in oncology regarding their patients management and prognosis worldwide. it also investigates the factors that affect these thoughts and expectations and their effects.

oncology patients need to trust the medical staff dealing with them. they are expecting knowledge, well communication, competence .. etc. this questionnaire is for research purpose aiming at exploring the thoughts and expectations of the medical staff in oncology regarding their patients management and prognosis worldwide. it investigates the factors that affect these thoughts and expectations and their effects. the results of this survey will shed the light on the oncologists' side of their relationship with their patients, which is often ignored or down played.

Eligibility criteria:
inclusion criteria: 1. medical/clinical/radiation oncology physicians 2. surgical oncology physicians 3. oncology nurses exclusion criteria: * medical staff not related to oncology field

Keywords: oncologists, survey, expectations
regional cerebral oxygen saturation in laparoscopic surgery

Conditions: Cholecyctitis

Summary: while few studies have determined the optimal intra-abdominal co2 insufflation pressure to achieve optimal surgical condition during lcs with deep-nmb and moderate-nmb in laparoscopic cholecystectomy (lc), previous studies suggested that the use of deep neuromuscular blockade (deep-nmb) can improve surgical condition and reduce the pressure for co2 insufflation to achieve "optimal surgical space condition". this difference in the pressure of intra-abdominal co2 insufflation due to different strategies employing deep-nmb and moderate-nmb for lc may produce possible difference in patient's respiratory pattern and cerebral oxygenation. although previous study (studies) showed that intra-abdominal co2 insufflation (10-12 mmhg) decreases cerebral oxy-hemoglobin (hbo2) and total hb measured by near-infrared spectroscopy (nirs) during laparoscopic cholecystectomy (lc), few studies have speculated possible impact of different degree of nmb and intra-abdominal co2 insufflation pressure on patient's cardiorespiratory profile and cerebral oxygenation, so far. the present study determines and compares the changes co2 absorption and cerebral oxygenation (cerebral perfusion) after applying co2 insufflation with different intra-peritoneal pressure 8 vs 12 mmhg during deep-nmb.


Eligibility criteria:
inclusion criteria: * cholecystitis * provision of written informed consent exclusion criteria: * copd * asthma * low lv ejection fraction
ventilation in cardiac arrest resuscitation study

Conditions: Heart Arrest, Out-Of-Hospital; CardioPulmonary Resuscitation; Basic Cardiac Life Support

Summary: out-of-hospital cardiac arrest (ohca) is a major public health problem, with around 40,000 victims each year in france. their survival rate remains dramatically low, at less than 10%. in the event of pre-hospital cardiac arrest, rescuers perform resuscitation techniques using equipment for which they have been trained. they perform cardiopulmonary resuscitation (cpr) by alternating 30 chest compressions with 2 insufflations (30/2) with a manual insufflator bag. in basic life supports, insufflations should result in chest rise, but guidelines do not specify a precise volume. recently, medical devices have been developed that enable precise measurement of ventilatory volumes. in simulation, these devices show hyperventilation in volume and frequency in mannequins. but no clinical study has analyzed insufflator bag ventilation maneuvers in real-life situations on pre-hospital cardiac arrest patients. the aim of this study is to analyze ventilation parameters in current practice in relation to standards, and the factors influencing the quality of ventilation maneuvers.


Eligibility criteria:
inclusion criteria: * out of hospital cardiac arrest with cpr performed by the firefighters * age 18 and over * bls team on site before arrival of physician staffed als means * cpr ventilation initially provided with bag-valve- mask * measuring device records ventilatory parameters exclusion criteria: * trauma related ohca * airway obstruction during cpr * ohca on hanging * tracheostomized patient * obstacle to using the bag-valve-mask * cpr time less than 2 minutes

Keywords: heart arrest cardiopulmonary resuscitation bag-valve-mask rescuers
pronostic interest of 18f-fdg pet/ct in patients with metastatic castration-resistant prostate cancer (mcprc) progressing

Conditions: Prostate Cancer

Summary: the aim of this retrospective study was to assess the prognostic value of parameters extracted from 18fdg pet/ct and 68ga-psma pet in the initial workup and follow-up of patients treated with 177lu-psma in mcrpc.

prostate-specific membrane antigen (psma) is expressed in most metastatic castration-resistant prostate cancer (mcrpc) cells. in response to this finding, a vectorized internal radiotherapy (vir) therapy was developed, lutetium 177-labeled psma, 177lu-psma. clinical trials have demonstrated its efficacy in men with metastatic castration-resistant prostate cancer . the number of patients treated in nuclear medicine departments has increased considerably in recent years, notably with the food and drug administration's (fda) and the european medicines agency's (ema) approval of this treatment (177lu-psma-617, pluvicto®) in the setting of progressive mcrpc after at least one line of 2nd-generation hormone therapy and one line of taxane chemotherapy. patients eligible for treatment benefit from pre-therapy 68ga-psma positron emission tomography (pet/ct) to assess psma expression by cancer cells, but 18fdg pet/ct, although mentioned in the eanm guidelines, is not routinely performed. for treatment follow-up of prostate cancer patients, the pcwg3 (prostate cancer working group 3) currently recommends conventional imaging (ct scan and bone scan) (4) and makes no mention of metabolic imaging, even though some lesions are not detectable with conventional imaging. in addition, one study reported that a high metabolic volume 18fdg pet/ct scan as part of the pre-therapy work-up for mcrpc prior to the introduction of 177lu-psma or cabazitaxel therapy was associated with a poorer response to treatment. the aim of this retrospective study was to assess the prognostic value of parameters extracted from 18fdg pet/ct and 68ga-psma pet in the initial work-up and follow-up of patients treated with 177lu-psma in mcrpc.

Eligibility criteria:
inclusion criteria: * patients treated with 177lu-psma for castration-resistant prostate cancer at nancy university hospital * patients with 68ga-psma and 18fdg pet scans as part of the initial workup and treatment follow-up exclusion criteria: * patients who did not give their consent to use their data retrospectively

Keywords: nuclear medicine prostate cancer pet scan
effects of pilates exercises in asthmatic patients

Conditions: Asthma

Summary: asthma is a chronic respiratory disease with high prevalence worldwide, considered an important cause of morbidity, mortality and high economic costs. aerobic physical exercise has great merit as non-pharmacological treatment and other exercise modalities have being studied. however, there are few data in the literature about the effects of pilates method in patients with asthma. the objective of this study is evaluate the effects of a program of exercise using pilates on health factors related to quality of life in patients with moderate or severe persistent asthma. patients will be also evaluated about disease control, anxiety and depression symptoms, functional capacity, lung function, respiratory muscle strength, thoracoabdominal mechanics and level of daily life physical activity. the investigators' hypothesis is that strengthening of the deep trunk muscles promotes a mechanical fixation of the thorax, contributing to the clinical improvement of patients with asthma.

this is a randomized, controlled and single blinded trial. thirty adults with moderate or severe persistent asthma will be randomly assigned into two groups: pilates method - pm (training group) or muscle stretching exercises - mse (control group). all subjects will receive the same educational session and will perform the physical exercise proposed for the group for 12 weeks, 3 times/week, 40-minute sessions. the data normality will be analyzed by kolmogorov-smirnov, the variables obtained before interventions will be compared with the student t-test or mann-whitney u-test. comparisons of the initial and final data on outcomes will be analyzed with repeated measures anova with appropriate post hoc of holm-sidak. the significance level will be set to 5% for all tests.

Eligibility criteria:
inclusion criteria: * asthma moderate and severe * asthma will diagnosed (global initiative for asthma -gina) * asthma medication according recommendations from gina * body mass index ≥18.5 kg/m2 and \<35 kg/m2 * sedentary * medical treatment, for at least 6 months * clinically stable (i.e., no exacerbation or medication changes for at least 30 days) exclusion criteria: * current or ex-smokers (who have given up smoking less than 1 year and/or tobacco charge greater than 10 pack-years) * cardiovascular, musculoskeletal and other chronic lung diseases * pregnant * active cancer * uncontrolled hypertension or diabetes * continuous use of oral corticosteroid * psychiatric disease or cognitive deficit

Keywords: asthma exercise pilates quality of life clinical control
randomized trial of early versus standard drainage removal after pancreatic resections

Conditions: Pancreaticoduodenectomy; Distal Pancreatectomy; Pancreatic Fistula; Abdominal Abscess

Summary: despite a substantial decrease in postoperative mortality, morbidity after pancreatic resections is still high, even at high-volume centers. it has been recently suggested that early removal of postoperative drainages is associated to a decreased rate of intra-abdominal complications, with particular regard to pancreatic fistula. furthermore, our research group demonstrated that measuring amylase value in drainages (avd) on postoperative day 1 plays a cardinal role in predicting the developement of abdominal complications, including pancreatic fistula. in particular, patients with an avd lower than 5000 iu/l in postoperative day 1 were considered at low risk of fistula. therefore, the investigators designed a randomized prospective trial on early (postoperative day 3) versus standard (postoperative day 5) drainages removal after pancreatic resections in patients at low risk of developing pancreatic fistula (avd \< 5000 iu/l in postoperative day 1) to test whether drainages "per se" influence postoperative complication rates and to eventually validate a fast-track policy in pancreatic resections.


Eligibility criteria:
inclusion criteria: * patients undergone either pancreaticoduodenectomy (reconstruction by pancreaticojejunostomy) or distal pancreatectomy with an amylase value in drains on postoperative day 1 less than 5000 iu/l exclusion criteria: * pancreaticoduodenectomy reconstructed with pancreaticogastrostomy * clinical suspect of postoperative haemorrhage within 72hours after the operation * clinical suspect of biliary fistula * fluid collection greater than 3cm at an ultrasound carried out on postoperative day 3
upper arm training with armeo spring for stroke

Conditions: Stroke

Summary: the purpose of this study is to assess the clinical outcomes of upper extremity training using the armeo spring system in a chronic post-stroke population with impaired upper extremity function.

the armeo spring system is an adjustable arm orthosis that has received fda 510k clearance. it passively counterbalances the weight of the arm, thereby reducing the effort required to overcome gravity during the performance of upper-limb movements. the device provides subjects with augmented feedback via a virtual environment (i.e. computer games). the tasks to be performed in the virtual environment are designed to achieve functional movements, such as arm reaching movements. the goal of the study is to assess the clinical outcomes of upper extremity training using the armeo spring system in a chronic post-stroke population with impaired upper extremity function. the armeo spring system is equipped with a grip sensor that subjects squeeze with their hand to interact with virtual objects during the games. in a first phase of the study, we attempted to replace the grip sensor that is part of the system with a sensorized glove, to facilitate a more natural movement of hand opening/closing. however, we experienced technical difficulties with the sensorized glove and decided to abandon this aim for the purpose of gathering data about the clinical outcomes of upper extremity training using the armeo spring system.

Eligibility criteria:
inclusion criteria: * male and female, community dwelling, age 18-70 * first-time non-traumatic ischemic or hemorrhagic stroke at least 3 months prior to study enrollment * score of 15-55 out of 66 on arm motor fugl-meyer scale * the ability to extend \>=10 degrees at metacarpophalangeal and interphalangeal joint of all digits exclusion criteria: * cognitive impairment that may interfere with understanding instructions for motor tasks and assessment tools * inability to operate the armeo system (subjects must have sufficient range of movement to enable calibration of the virtual workspace) * participation in other forms of therapy/intervention for upper extremity motor recovery

Keywords: stroke rehabilitation
effect of strength training on executive functions in elderly people with mild cognitive impairment

Conditions: Strength Training; Executive Function

Summary: cognitive impairment or dementia is their last degree in one of the main concerns at a social level in these ages. to this day, there are different pharmacological and non-pharmacological therapies that can help prevent deterioration, as in this case, physical exercise. in the existing scientific literature, you can find a lot of information about the effect of aerobic exercise on cognition, but little is known about the effect of force exercise and its effect on general cognition and executive functions. therefore, in this research the investigators will investigate the effect of strength training in people over 60 with a diagnosis of mild cognitive impairment in executive functions. for this, a controlled and randomized clinical trial will be developed in the city of seville

the training program will last 20 weeks and a frequency of 3 times / week. during the week 0 the initial evaluation will be developed. between weeks 1-20, the training program will be addressed. in week 21, all the changes made in all the measured variables will be evaluated. finally, in week 33 the variables will be measured again to see if the possible improvements given in the training program last over time. the experimental group will perform a planned and individualized training with guided machines and training loads will be adjusted at the beginning of each week. the control group will perform breathing and relaxation exercises to avoid a sample death. after the intervention, there will be a follow-up phase for 3 months.

Eligibility criteria:
inclusion criteria: * the sample is made up of people over 60 years of age, who are not active professionally, speak and understand the spanish language. * in addition, they should be diagnosed with mild cognitive impairment. this will be evaluated by specialists through the minimental test (score between 24 and 28). * on the other hand, they should not suffer from other serious psychiatric or neurodegenerative neurological diseases. * in relation to mental health, it will be a reason for exclusion to have had 3 episodes of depression in the last 5 years or 10 episodes that have required some psychiatric or medical treatment.in addition, * the people included must be postmenopausal exclusion criteria: * participate in other physical exercise programs in a systematic way or in individualized and systematic programs in cognitive programs. * dispose of cardiovascular diseases, heart diseases that involve an absolute contradiction of physical exercise (unstable angina, severe auroventricular block) and cerebrovascular or have suffered a heart attack in the last 6 years. * have had seizures (more than 2 in the last 12 months). * consumption of alcohol 20 grams / day or 2 beers or wine glasses daily. * functional limitations (according to functional activities questionnaire) * being a musician or bilingual.