Kornimate/medical-research-clean huggingface dataset:
epidemiology and outcome of solitary fibrous tumors of the pleura.

Conditions: Solitary Fibrous Tumors of the Pleura

Summary: 1. to determine the incidence, prevalence and long-term outcome of patients with sftp in the german spoken part of switzerland. 2. to define the role of immunohistochemical and molecular techniques, such as immunostaining, fish and mutational analysis regarding their ability to predict malignant behavior in terms of prediction of overall survival and disease-free survival.

retrospective observational study on patients with sfpt in the german spoken part of switzerland between 2000 and 2011 (approximately 300 patients): phase 1) information leaflet (letter of invitation) from study center (university hospital of zurich) to the institutes for pathology from all university, cantonal and city hospitals in the german spoken part of switzerland. patient recruitment performed by medical staff from the aforementioned institutes for pathology. phase 2) obtaining first orally (by telephone) and thereafter written informed consent from the patients performed by medical staff from the aforementioned institutes for pathology. phase 3) after written and oral consent has been given, a doctoral candidate (member of the study group, student of the university of zurich) will perform the data entry based on clinical and histological records locally at each external institute for pathology (no patient record files will be copied or transferred in original to the university hospital of zurich). data entry in the electronic case report from (excel file on study laptop) will be performed with anonymous data only. hence, each patient will have a study number containing the treating hospital, year of diagnosis and a consecutive number (e.g. kssg-2011-1, kssg-2011-2, stz-2007-1, stz-2007-2, ...). no names or birth dates will appear in the case report form. provided that informed consent is given, patient follow-up will be performed by contacting the primary care physician (general physician or family doctor) by telephone, which is handled by the doctoral candidate. deceased patients will not be incorporated within the study. phase 4) review of the histological specimen which are collected by the aforementioned doctoral candidate and brought to the university hospital of zurich, institute for pathology, where immunohistochemical/molecular examinations, such as immunostaining, fluorescence in situ hybridization (fish) and mutational analysis of the histological specimen are performed by pd dr. a. soltermann, member of the study team. after this, the specimens are returned to the original institute for pathology, where they were taken. all specimens are made anonymous at the moment of collection at the external hospital by the doctoral candidate (each specimen is labeled with the aforementioned study number, which is assigned in the case report form). phase 5) data analysis, publication.

Eligibility criteria:
inclusion criteria: * histologically proven diagnosis of sftp between 2000 and 2011. exclusion criteria: * missing informed consent
quantitative prognostic analysis of upper limb motor dysfunction after stroke

Conditions: Stroke; Rehabilitation; Tobacco Use; Upper Extremity Dysfunction; Prognosis; Functional MRI

Summary: 30% - 66% of stroke survivors have upper limb dysfunction. effective rehabilitation can improve the prognosis, but the rehabilitation resources are limited. how to evaluate the prognosis early and formulate an individualized rehabilitation plan based on realistic expectations is still inconclusive. the current research shows that some brain network changes are related to the recovery of motor function. the dynamic connection of multi-modal and spatio-temporal fusion of motor network is helpful to the prognosis analysis of upper limb dyskinesia after stroke. 178 stroke patients will be included in this project. fugl-meyer motor function scale (upper limb part) and action research arm test (arat) will be evaluated at enrollment, 1month/3month/6month after onset. according to the results, the groups with good prognosis and poor prognosis will be distinguished; blood oxygen level dependent imaging and diffusion tensor imaging will be collected at the same time to compare the similarities and differences of the function and structural connection of the motion network; the correlation between interhemispheric connection, intrahemispheric connection, cross network connection of motor network and prognosis will be analyzed, the clinical and imaging features of different prognosis will be extracted. this study can provide scientific data support for the prognosis analysis of upper limb dysfunction after stroke, the improvement of rehabilitation clinical decision-making and the optimization of rehabilitation resource allocation.


Eligibility criteria:
inclusion criteria: * first stroke with upper limb motor dysfunction, stable condition; 18 ≤age≤80 years old; the onset time was less than 3 weeks at the time of enrollment; sign informed consent. exclusion criteria: * stroke patients with intracranial infection, multi-system atrophy and other central nervous system diseases; combined with severe aphasia, visual spatial neglect and other cognitive impairment; untreated spasm (ashworth ≥ grade 2); obvious joint contracture restricting the movement of upper limb; in vivo metal implants; claustrophobia.
intracochlear dexamethasone application during cochlear implantation for preserving cochlear cells

Conditions: Hearing Loss, Sensorineural

Summary: the protection of cochlear cells is one of the main concerns of cochlear implant surgery. new electrode designs or additional molecules have been used for this purpose. the aim of the study is to test the effect of dexamethasone in two different application methods.

the protection of cochlear cells is one of the main concerns of cochlear implant surgery. new electrode designs or additional molecules have been used for this purpose. the aim of the study is to test the effect of dexamethasone in two different application methods. participants who will have cochlear implant surgery will be divided into three groups. group 1 will have intracochlear dexamethasone after the incision of the round window membrane. group 2 will have intratympanic dexamethasone after the incision of the round window membrane. group 3 will serve as a control group. all participants will be tested after a week, a month, 3, and 6 months. impedance and threshold measurements will be compared.

Eligibility criteria:
inclusion criteria: * patients with sensorineural hearing loss * patients who will have cochlear implant surgery with ci422 electrode exclusion criteria: * patients with cochlear abnormality * patients with auditory neuropathy

Keywords: cochlear implant dexamethasone
ism1 versus embriogen media for embryo culture with previous failure implantation in art treatments

Conditions: Infertility; Implantation Failure

Summary: recently, it has been suggested that culture of embryos in embryogen medium can increase the live birth rate in ivf patients with a previous history of pregnancy loss. couples requiring ivf treatment and with a past experience of implantation failure will be included in the study. controlled ovarian stimulation protocol will consist of an agonist down regulation and follicular stimulation by recombinant fsh. fertilization will be achieved by standard ivf or intracytoplasmic sperm injection. fertilized eggs will be cultured in 6% co2, 5% o2, 89% n2 atmosphere in microdrops. in the treatment group embryogen culture medium (eg, origio, måløv, denmark) will be adopted throughout the culture period. in the control group, inseminated oocytes will be cultured in standard culture conditions, i.e. ims1 medium (ism1, origio, måløv, denmark), maintaining unchanged all other culture conditions. procedures of embryo transfer, will be carried out on day 2 using embryogen or ism1 respectively. the endometrial support will be the same in the two groups.


Eligibility criteria:
inclusion criteria: * women experiencing at least two (maximum 4) failures of implantation after art treatments (with elective embryo transfer) exclusion criteria: * frozen spermatozoa * frozen oocytes * women pco and pcos * women with previous pregnancy, miscarriage or biochemical pregnancy

Keywords: ivf embryo culture ongoing pregnancy rate ongoing implantation rate miscarriage
understanding mechanisms of health behavior change

Conditions: Overweight and Obesity; Diet Modification; Incentives

Summary: this research seeks to examine psychological factors that may impact relationship between incentives and health behavior engagement, specifically fruit and vegetable consumption. additionally, it will compare the impact of two different incentive schedules on behavior engagement, one providing immediate rewards (i.e. rewards received on a daily basis) and another providing delayed rewards (i.e. rewards received at the end of the study period), with a control condition in which no rewards are offered. study participants will provide reports of their fruit and vegetable consumption each day for three weeks, and in the two incentive conditions, they will receive small monetary rewards for their fruit and vegetable consumption. following the three week reporting and reward period, participants will complete two additional assessments, measuring psychological constructs and behavior engagement following the cessation of rewards. the study will also examine how cognitive and anthropomorphic factors may contribute to intervention response and the effects on psychological constructs.


Eligibility criteria:
inclusion criteria: * consume fewer than 3 servings/day of fruits and vegetables * daily access to internet for 3 weeks following baseline session * have or are willing to create an account on paypal * bmi greater than or equal to 25, from self-reported height and weight exclusion criteria: -
the effects of telerehabilitation and chair-based yoga in the elderly

Conditions: Telerehabilitation; Chair-based Yoga; Elderly People

Summary: the aim of the study is to investigate the effects of chair-based yoga with rehabilitation on quality of life is affected in elderly people. depending on the changes in the body as a result of aging, people's quality of life is affected. in order to increase or protect the quality of life in elderly people, telerehabilitation practices are emphasized. telerehabilitation is a promising system for the elderly thanks to its advantages. as a practice, chair-based yoga, a modified form of yoga, was preferred. chair-based yoga makes yoga more doable and safe for older people. chair-based yoga with telerehabilitation was performed with the participants. pain level, sleep status, functional capacity, quality of life, mental health and depression were followed by evaluations at the beginning and end of the process.


Eligibility criteria:
inclusion criteria: * 65 years and over, * having a standardized mini mental test score of 24 and above, * physically active (self-sustaining), exclusion criteria: * severe cardiopathy, * uncontrolled hypertension, * mental disorder, * presence of any health condition that may prevent functional autonomy test such as hearing and vision, * have mental disorders and dementia, * people with any unstable medical condition

Keywords: depression quality of life quality of sleep pain chair-based yoga telerehabilitation
breathing exercises to improve fatigue and quality of life in hemodialysis patients

Conditions: Hemodialysis; Breathing Exercises; Fatigue

Summary: breathing exercises to improve fatigue and quality of life in hemodialysis patients

patients receiving haemodialysis have poor physical function, psychological status and quality of life than the general population.fatigue is a debilitating symptom in haemodialysis patients exercise training may improve these parameters for haemodialysis patients. a 3-month randomized control trial with baseline、week 4、week 12 measurement periods was conducted. exercise group was taught to breathing exercise week and usual care for three months. the control group received usual routine care. a total of 86 patients participated in this study, with 43 patients in the exercise group and 43 patients in the control group methods: hemodialysis fatigue scale 、 whoqol-bref 、 hads_ anxiety 、 hrv

Eligibility criteria:
inclusion criteria: 1. diagnosed by end-stage renal disease, regular hemodialysis three times a week and up to six months or more 2. adults over 20 years of age. 3. consciousness. 4. can be used to communicate in taiwanese, accept questionnaire interviews or self-filling questionnaire. 5. no chest pain or shortness of breath symptoms. 6. no lower extremity disability and ability to walk on their own. 7. agree to take respiratory exercise intervention measures, have the intention to participate in this study and signed a consent form. exclusion criteria: 1. unstable vital signs, or serious heart disease: such as the diagnosis of myocardial infarction, unstable angina pectoris, cardiopulmonary disease and other patients. 2. a complication occurs, such as aspiration pneumonia. 3. history of arrhythmia, as well as taking heart rate medication. 4. physician's advice is not suitable for exercise, such as bone and joint problems. 5. there is a temporary double vena cava catheter placed.

Keywords: breathing exercises fatigue quality of life
a trial of chemotherapy before and after surgery for stage ii,iii esophageal squamous cell carcinoma

Conditions: Esophageal Neoplasms; Carcinoma, Squamous Cell

Summary: to determine whether chemotherapy before surgery makes better outcome than chemotherapy after surgery in patients with esophageal squamous cell carcinoma

the previous study jcog9204 showed that postoperative adjuvant chemotherapy with cisplatin and fluorouracil has a detectable preventive effect on relapse in patients with esophageal squamous cell carcinoma compared with surgery alone.(j clin oncol 2003;21:4592-4596) therefore the standard treatment for stage ii and iii esophageal cancer is adjuvant chemotherapy after surgery.

Eligibility criteria:
inclusion criteria: 1. histologically proven squamous cell carcinoma of the thoracic esophagus 2. pathologic stages iia, iib, iii except t4 3. an eastern cooperative oncology group (ecog) performance status of 0 to 2 4. no previous history of chemotherapy nor radiotherapy 5. an essentially normal clinical laboratory profile (white blood cell count or wbc, \>=4,000 /mm3; hemoglobin or hb, \>=10g/dl; platelet count or plt, \>=100,000 /mm3; total serum bilirubin\ =60 ml/minute; and arterial oxygen tension or pao2, \>=65 torr 6. oral or written informed consent obtained before randomization exclusion criteria: 1. severe heart diseases 2. uncontrollable hyper tension or diabetes mellitus 3. severe pulmonary dysfunction 4. hbs positive 5. active bacterial infection 6. synchronous or metachronous (within 5 years) malignancy 7. pregnant female 8. psychiatric medication

Keywords: esophageal cancer squamous cell carcinoma esophagectomy neoadjuvant chemotherapy esophageal squamous cell carcinoma
study of granulocyte-macrophage colony-stimulating factor (gm-csf) for patients with rising prostate-specific antigen (psa)

Conditions: Prostate Cancer

Summary: this is a phase ii study to test the efficacy of exogenously administered gm-csf in prostate cancer patients who have failed definitive local therapy, and have only serologic (psa) evidence of progression.


Eligibility criteria:
inclusion criteria: * histologic diagnosis of adenocarcinoma of the prostate; stage t1-t3, n0-n1, m0 * prior definitive therapy for primary prostate cancer consisting of:external beam radiotherapy;brachytherapy with or without pelvic external beam radiation; or radical prostatectomy with or without adjuvant or salvage radiation therapy * therapeutic psa response to primary therapy below 1.0 ng/ml post radiation therapy or below 0.4 ng/ml for radical prostatectomy * patients treated with adjuvant or salvage radiation therapy following radical prostatectomy are eligible provided:post prostatectomy psa was never \> 6.0 ng/ml, last effective day of androgen deprivation is at least 3 months prior to study entry * recurrent psa level elevation (between 0.4 ng/ml and 6.0 ng/ml) on two determinations at least one week apart. * no clinical evidence of gross local recurrence or known metastatic disease other than psa elevation. transrectal ultrasound and/or biopsy to evaluate local recurrence is not required. all patients will receive a bone scan and ct scan of the abdomen to exclude metastases. * estimated life expectancy of at least 6 months. * ecog performance status of 0 or 1. * willing and able to give informed consent. exclusion criteria: * cryosurgery as definitive therapy of primary tumor. * any metastasis. * no concurrent or prior malignancy is allowed except for the following: adequately treated basal or squamous cell skin cancer, adequately treated stage i or ii cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease-free for 5 years. * current systemic steroid therapy (inhaled or topical steroids acceptable). * prior hormonal therapy for treatment of progressive disease. * prior chemotherapy, immunotherapy, or therapy with other experimental agents for prostate cancer. * any surgery within the prior 4 weeks. * bilirubin and sgot \> 2 x upper limit of normal. * bun and serum creatinine \> 2.0 times normal. * no active congestive heart failure. * if there is a history of clinically significant obstructive airway disease, a dlco must exceed 50%. * active uncontrolled bacterial, viral or fungal infection until these conditions are corrected or controlled. * any underlying medical condition which in the principal investigator's opinion will make the administration of gm-csf hazardous or obscure the interpretation of adverse events. * psa \> 6.0 ng/ml
ai in hypertension treatment education: comparing gpt and traditional methods

Conditions: Medical Education; Hypertension; GPT

Summary: educational trial: gpt-based training vs. traditional teaching for hypertension management the goal of this educational trial is to determine whether a generative pre-trained transformer (gpt)-based training system is more effective than traditional teaching methods in helping medical students master hypertension management plans. it will also evaluate the educational effectiveness and engagement of the gpt-based system. the main questions it aims to answer are: does the gpt-based training improve the ability of students to develop effective hypertension management plans compared to traditional methods? how do students perceive the use of the gpt system in their learning process? researchers will compare the gpt-based training system to traditional teaching methods to see if the innovative ai approach enhances learning outcomes in medical education. participants will: engage with either the gpt-based system or traditional teaching materials. visit the educational facility periodically for assessments and feedback sessions. keep a diary of their learning experiences, noting any difficulties or advantages they observe in the training method they are assigned.


Eligibility criteria:
inclusion criteria: * graduate or regulatory trainee, currently rotating in cardiology and willing to participate in research. * age between 18-30 years old, gender not limited. * no specialized training experience in hypertension diagnosis and treatment, only possessing basic medical theoretical knowledge. * able to accept a 4-week teaching intervention (2 hours of study per week). * sign the informed consent form and be aware of the research purpose and process. exclusion criteria: * graduate students or trained interns who have received specialized training in hypertension medication treatment. * students unable to complete the full course of study (e.g., rotations shorter than four weeks or potential mid-course withdrawal). * unable to consistently participate in educational interventions (e.g., conflicts with study schedule). * have severe physical or mental health issues that may affect the learning process. * have language comprehension barriers or cognitive impairments, making it difficult to complete learning tasks.
impact of minimally invasive and open liver surgery in different bmi-classes

Conditions: Liver Cancer; Liver Metastases; Obesity

Summary: despite the worldwide increase of both obesity and use of minimally invasive liver surgery(mils), evidence regarding the safety and eventual benefits of mils in obese patients is scarce. the aim of this study is therefore to compare the outcomes of non-obese and obese patients(bmi 18.5-29.9 and bmi≥30, respectively) undergoing mils and ols, and to assess trends in mils use among obese patients. in this retrospective cohort study, patients operated at 20 hospitals in eight countries(2009-2019) will be included and the characteristics and outcomes of non-obese and obese patients will be compared. thereafter, the outcomes of mils and ols were compared in both groups after propensity-score matching(psm). changes in the adoption of mils during the study period will be investigated.


Eligibility criteria:
inclusion criteria: * patients aged 18 years and older * patients that have undergone an elective minimally invasive or open liver resection exclusion criteria: * patients that have undergone a hand-assisted or robotic procedure * patients with a bmi lower than 18.5

Keywords: overweight fatty liver open liver resection laparoscopic liver resection minimally invasive liver resection