Kornimate/medical-research-clean huggingface dataset:
the impact of exercise approaches on sleep in children with acute lymphoblastic leukemia

Conditions: Oncology Problem; Sleep

Summary: sleep is one of the basic and indispensable daily life activities that affect the quality of life and health of individuals and is a concept with physiological, psychological and social dimensions. in the literature, sleep difficulties and problems have begun to be investigated in children with acute lymphoblastic leukemia and have not been found in national publications. in these children, sleep quality, strengths and disorders and a study evaluating this variation on a scale have not been found. for this reason, our study will be done in order to determine the factors affecting sleep and sleep in children with cancer and to show the effect of exercise on these factors.

primeraly that progresses in the disease process, secondary problems seen with the effects of symptoms make it difficult to cope with disease and treatment process in children with acute lymphoblastic leukemia (all) . sleep difficulty is not affected by the direct effects of the disease but it is affected and becomes more difficult with the fatigue and difficulty of treatment as a secondary. parents with all children stated that they experienced 12.4% of sleeping difficulty. it turns out that about a quarter of the children are sleeping problems. it is stated that 27% of these children have drowsiness, and more than 25% of them have frequent awakenings at night. it is also stated that parents use the option of rest-sleep as an option to benefit from treatment in coping with the disease, but children with sleeping difficulties also make it difficult to treat them. being a healthcare professional as a biopsychosocial approach model and planning the treatment interventions for the deficiencies and disorders that will be done in order to get rid of the symptoms of the disease as soon as possible will make it easier to cope with the disease with both child and parent and multidisciplinary approach. in this way, we will investigate the effects of children's exercise habits on their sleep and sleep related complaints by using video-based game consoles which are currently used in our workout approaches. the games to be selected from the aerobic exercise programs that are used to increase the functional capacity on the basis of exercise will also be targeted to the exercises with maximum motivation and participation of the children. in the exercises where goodness and continuity are also taken into consideration, in-game guidance will be provided with verbal commands under the supervision of a physiotherapist.

Eligibility criteria:
inclusion criteria: * having all a diagnosis * being between 2-18 years of age * therapy (surgery, chemotherapy, radiotherapy) to be finished exclusion criteria: * continue active treatment (surgery, chemotherapy, radiotherapy) * recurrence of the disease * any mental / physical problem that will have a cooperative problem

Keywords: exercise sleep problems acute lymphoblastic leukemia
v+psf-m for tobacco cessation in hiv care in india

Conditions: Human Immunodeficiency Virus; Smoking Cessation; Smoking, Tobacco

Summary: the goal of this research study is to test an intervention to help quit tobacco use in participants with human immunodeficiency virus (hiv). the study interventions used in this research study are: * positively smoke free - mobile (psf-m) (mobile behavioral program) * varenicline (or chantix, apovarenicline, champix or nocrav)

open-label, practice-based randomized trial of varenicline + positively smoke free-mobile (psf-m) for people living with human immunodeficiency virus (pwh) who smoke or use both smoked and smokeless tobacco compared with a group that receives standard care including brief advice and quitline referral. positively smoke free (psf) is a behavioral intervention which has been tested in multiple formats including a mobile version. varenicline is the single most-effective pharmacotherapy agent for quitting tobacco with demonstrated efficacy for cessation of cigarettes, smokeless tobacco, and cessation among smokers with comorbidities in this study, participants will be randomized to either group 1: varenicline + positively smoke free-mobile adapted for chennai versus group 2: standard care with brief tobacco cessation advice and referral to the national quitline. research procedures include screening for eligibility, in-clinic visits, and completion of surveys and questionnaires. participation in this study is expected to last about 24 weeks. it is expected about 400 people will take part in this research study. this study is funded by the national cancer institute of the national institute of health (nih).

Eligibility criteria:
inclusion criteria: * adults (≥18 years) * confirmed hiv diagnosis * self-reported current smoking or dual tobacco use verified either by exhaled carbon monoxide ≥7 ppm, or by positive qualitative cotinine point-of-care test * able to read at 6th grade level or greater and speak tamil, telugu or english * able to use varenicline safely based on evaluation by primary provider at vhs * women of childbearing potential who consent to use a medically approved method of contraception or abstain from intercourse while taking study medication and for one month after. * ready to quit or interested in quitting exclusion criteria: * pregnant or planning to become pregnant in the next 6 months * breastfeeding * myocardial infarction in past 30 days or unstable angina * history of liver or kidney failure * alanine aminotransferase and aspartate aminotransferase \> 2 times upper limit of normal or creatinine clearance \<50 in past 6 months * history of suicide attempt * current suicidal ideation * untreated or unstable major depressive disorder * history of psychosis or on anti-psychotic medications * cognitive impairment limiting ability to consent * allergy to varenicline

Keywords: human immunodeficiency virus smoking cessation smoking, tobacco
a 3-month cycle of weekly montreal museum of fine arts tours

Conditions: Social Interaction; Quality of Life; Health

Summary: social isolation in older community-members living in urban areas and its possible reduction through a 3-month cycle of weekly museum tours.

social isolation is a major problem for the canadian society because of its: (1) high prevalence in the older population (30% in individuals aged 65 and over, which represents 1.5 million individuals), (2) association with a wide range of mental and physical health problems and (3) increased use of health and social services. museum art-based activities have demonstrated benefits on an individual's sense of social inclusion, their well-being, their quality of life and physical frailty. few studies have examined the effects of the participation in museum art-based activities in older community members experiencing social isolation. in 2019, the team conducted an experimental pilot study comprised of pre-post intervention, single arm, prospective and a longitudinal follow-up. this experiment indicated that a 3-month cycle of weekly visits to the montreal museum of fine arts (mmfa) in the form of a guided tour may improve the social inclusion of socially isolated older adults. we hypothesize that it is possible to reproduce these previous positive results using a mixed methods approach that combines: (1) a qualitative phase comprised of observation of the guided tours; semi-structured interviews, focus groups and an analysis of relevant organizational documents; (2) a quantitative phase based on a randomized clinical trial (rct). over a two-year period, we will examine whether and how a 3-month cycle of weekly mmfa tours may (1) improve social inclusion, well-being and quality of life, and (2) reduce frailty in older community members, living in montreal, who are experiencing social isolation. the study includes the participation of community workers who work with socially isolated older montrealers, members of this community, as well as museum works and administrators. our research will not only include information on how the museum experience has affected older adults. it will incorporate feedback from all of these participants leading to an evaluation of the program offered by the museum to better serve the future needs and desires of this population. it will also benefit the participating organizations.

Eligibility criteria:
inclusion criteria: 1. being 65 years and over 2. having an internet access with an electronic device (i.e.; laptop, computer, smartphone, tablet) at the participant's place of living as the repetitive assessments for this study will be performed on the web platform of the centre of excellence on longevity of mcgill university 3. understanding and writing the language of the recruitment centre (i.e., french or english) 4. life expectancy estimated over 3 months as the duration of the follow-up is 3 months exclusion criteria: 1. concomitant participation to another clinical trial, 2. having participated to a participatory art-based activity of the mmfa, 3. not speaking the language of the study.

Keywords: community-dwellers older adults museum art
dumping syndrome and quality of life after vagus nerve-preserving distal gastrectomy

Conditions: Stomach Neoplasm

Summary: there is no consensus on what type of function-preserving gastrectomy can provide the best patient quality of life (qol). this study aims to evaluate the incidence of dumping syndrome after vagus nerve-preserving distal gastrectomy (vpndg).

the study is designed as a prospective observational phase ii study with a follow-up period of 12 months. patients diagnosed with early gastric cancer in the distal 2/3rd of the stomach who are planned to undergo laparoscopic vpndg with roux-en y gastrojejunostomy will be enrolled. primary endpoint is incidence of dumping syndrome defined by sigstad score 7 after a 3-month interval. other outcomes include operative data, early complication, and patient qol using the european organization for research and treatment of cancer c-30 and sto22 modules.

Eligibility criteria:
inclusion criteria: * patients diagnosed with early gastric cancer in the distal 2/3rd of the stomach planned to undergo laparoscopic vagus nerve-preserving distal gastrectomy exclusion criteria: * sacrificed vagus nerve * anastomosis other than roux-en y gastrojejunostomy or uncut roux-en y gastrojejunostomy * conversion to an open procedure * combined resection of other organs
feasibility and acceptability trial of a video based cbt guided self help intervention for people with low literacy

Conditions: Depression; Anxiety

Summary: this study aimed to assess the feasibility, acceptability, and preliminary efficacy of a video-based cbt guided self-help intervention 'khushi or khatoon' to treat anxiety and depression.

cognitive behaviour therapy (cbt) is now included in the national treatment guidelines in the uk. however, little progress has been made in its delivery in developing countries. limited resources for the delivery of services and their concentration in big cities have implications for the choice of mode of delivery of treatment. a range of methods are needed to deliver treatment starting from self-help to more specialist interventions. various cbt based self-help materials have been assessed and shown to be effective in the west . the effectiveness of a culturally adapted cbt (cacbt) based guided self-help has been reported, supervised by carers, against care as usual in patients with depression, who attend secondary care in pakistan . however, cbt requires a person to be literate, especially for guided self-help or self-help. pakistan has a literacy rate (ability to read or write) of 58%. an estimated 67% of children study up to primary level (years 1-5) and an estimated 43% have achieved secondary education (up to year 12). these are mostly people from low socio-economic backgrounds who are less likely to suffer from mental health problems such as depression and anxiety. in order to overcome this barrier a video intervention based on self-help intervention is developed. this study aims at testing the feasibility, acceptability and preliminary effectiveness of this intervention. this will be a rater-blind rct to evaluate the feasibility and acceptability of video-based guided self-help in addition to treatment as usual (tau) compared with the waitlist and tau in pakistan. this study will employ a pre-post measure and parallel design. it will be conducted from march 2023 to august 2023. participants who met the inclusion criteria will be randomly allocated to one of the groups, i.e. cbt video plus tau (intervention group) or waitlist plus tau (control group) in a 1:1 ratio.

Eligibility criteria:
inclusion criteria: 1. individuals aged 18 to 65 years 2. without schooling 3. able to use a smartphone 4. owning a smartphone or a personal computer with a reliable internet connection 5. score of 8 or higher on hospital anxiety and depression scale-depression or anxiety scales exclusion criteria: 1. substance use disorder according to dsm-5 criteria as determined by primary care clinician 2. significant cognitive impairment (for example, profound learning disability or dementia) as determined by primary care clinician 3. active psychosis as determined by their primary care clinician

Keywords: cbt self-help intervention anxiety, depression rct
a short treatment study of aripiprazole in pediatric patients with autistic disorder

Conditions: Autistic Disorder

Summary: the objective of this study is to investigate the efficacy and safety of aripiprazole orally administered over a period of 8 weeks in pediatric patients with autistic disorder


Eligibility criteria:
inclusion criteria: * the patient meets current dsm-iv-tr diagnostic criteria for autistic disorder (defined in dsm-iv-tr) and also demonstrates behaviors such as tantrums, aggression, self-injurious behavior, or a combination of these problems. * inpatient or outpatient status * others exclusion criteria: * the patient is currently diagnosed with another disorder on the autism spectrum in dsm-iv-tr, including asperger's, rett's disorder, pdd-nos, childhood disintegrative disorder, or fragile-x syndrome. * patients who fall under a contraindication listed in the abilify package insert * others

Keywords: autistic disorder, children and adolescents aripiprazole double-blind randomized children and adolescents
the effect of pulmonary rehabilitation on cognitive status in lung transplantation candidates

Conditions: Cognitive Impairment; Pulmonary Rehabilitation

Summary: pulmonary rehabilitation program with aerobic and strengthening for 3 months will be applied to the candidates for lung transplantation. the program will be designed to be 2 days supervised weekly and 3 day home program. cognitive functions and exercise capacities of the patients before and after the program will be evaluated.

the fact that cognition is not always included in the assessment routine makes it difficult to clarify which patient group or severity of illness is more affected by this issue. the effect of exercise on cognitive functions is a remarkable issue in recent years. it can also be predicted that cognitive function may be effective on program adaptation in patients who are given home program without supervision. the aim of the investigator's study was to investigate the effect of pulmonary rehabilitation on cognitive status in candidate lung transplant recipients. lung transplantation candidates who refered from lung transplantation surgery team will receive the pulmonary rehabilitation program for 3-months (2 days at hospital, 3 days at home). exercise program includes aerobic (walking band, bicycle, arm ergometer) and strengthening (with free weights) components. patient will evaluate at the beginning and end of the program. demographic information, diagnosis distributions, educational status of patients will be recorded. exercise capacities are determined by 6 min walk test. the medical research concil dyspnea scale is used in determining the dispense levels. montreal cognitive function assessment (moca) is used to determine cognitive functions. cognitive functions and exercise capacities of the patients before and after the program will be evaluated.

Eligibility criteria:
inclusion criteria: * to be listed for lung transplantation, * pulmonary rehabilitation exercise program planned to be taken, * volunteers who have agreed to participate in the work, * patients who can complete the 3-month pulmonary rehabilitation program. exclusion criteria: * failure to complete the planned exercise program for any reason, * not to be literate.

Keywords: lung transplantation cognition moca exercise pulmonary rehabilitation
wheelchair mobility assessment of individuals with spinal cord injury

Conditions: Spinal Cord Injury

Summary: the specific aims of this study are: 1) to assess the test-retest reliability of a modification of an existing wheelchair propulsion assessment and 2) validate the modification against traditional measures of physical strength, power, and endurance in a group of persons with spinal cord injury (sci).

the ability to independently self-propel and transfer oneself is a crucial component of daily life for individuals with a spinal cord injury. this ability is related in part to an individual's strength, power, and endurance, but it is unknown which of these measures is most important to achieve a high level of wheelchair function. identification of which physical performance parameters are best related to wheeled mobility performance is essential in developing interventions to improve said performance. currently, clinic-friendly assessments of a person's wheeled mobility ability do not exist. we have developed a modified, clinic-friendly version of validated wheelchair mobility assessment that can be completed in most clinics. before it can be implemented by clinicians its reliability must be established. crossvalidating it against standard measures of physical performance will allow for the identification of the most appropriate exercise interventions to improve independent wheeled mobility.

Eligibility criteria:
inclusion criteria: * spinal cord injury * american spinal injury association impairment scale (ais) a-d * self-reported ability to self-propel themselves in a manual wheelchair * age 18 or older exclusion criteria: * surgery within 6 months * pressure ulcer within 3 months * upper limb pain that limits completion of exercise * recurrent acute infection or illness requiring hospitalization or iv antibiotics * pregnancy * previous myocardial infarction or cardiac surgery
bortezomib for treating glomerular diseases

Conditions: Bortezomib; Glomerulonephritis; MN; MPGN; FSGS; IgA Nephropathy

Summary: bortezomib is a proteasome inhibitor that inhibits autoantibody production, and reduces podocyte damage and mesangial hyperplasia caused by nf-κb activation in the kidney. literature has reported that bortezomib can achieve a complete response rate of up to 38% in the treatment of glomerular diseases, but its safety and effectiveness remain to be assessed for the chinese demographic. this study attempts to explore a new treatment plan for glomerular disease by observing the therapeutic effect of bortezomib on glomerular disease.


Eligibility criteria:
inclusion criteria: * glomerular diseases confirmed by renal biopsy (including iga nephropathy, membranous nephropathy, fsgs, etc.) * aged 18-65, male or female * signed informed consent * 24h proteinuria \>1.5g/24h * glomerular filtration rate (egfr) \>30ml/min/1.73m2 (calculated according to ckd-epi formula) within 14 days before enrollment. * blood pressure \<140/90mmhg after drug treatment * unless there are contraindications, subjects must take a steady dose of acei and/or arb for at least 4 weeks before screening exclusion criteria: * renal pathology: glomerulosclerosis ratio \>70%, interstitial fibrosis \> severe * received immunosuppressant treatment within the past 6 months * inability to tolerate bortezomib * platelet count \< 30×109/l within 14 days before enrollment * neutrophil count \< 1.0×109/l within 14 days before enrollment * subjects had \>grade 2 peripheral neuropathy within 14 days before enrollment * ecg evidence of myocardial infarction or nyha class iii or iv heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmia, or acute ischemia or active conduction system abnormalities within 6 months before enrollment * abnormal liver function such as alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) \>=3 times normal upper limit (uln), total bilirubin \>= 2 times uln * newly diagnosed malignant tumor (within 5 years) or undergoing radiotherapy/chemotherapy * women who are pregnant or breast-feeding, or women of childbearing age who cannot guarantee effective contraception * new serious life-threatening infections * active infectious diseases such as active tuberculosis, active viral hepatitis, hiv infection. * mental disorders and psychotropic drug uses * patients with an estimated life expectancy of fewer than 12 months * patients that were difficult to follow up on or had poor compliance * patients who do not wish to sign the form of informed consent
treatment of major depressive disorder with bilateral theta burst stimulation

Conditions: Major Depressive Disorder

Summary: this is a randomized, double-blind, sham-controlled multicenter clinical trial. the aim is to provide evidence for efficacy of tbs in the treatment of patients with major depression. there will be a direct comparison between combined ctbs/itbs with sham tbs. overall, 236 patients with major depression will be randomized either to active tbs or sham tbs in a 1:1 ratio. the planned stimulation paradigms will be applied as add-on therapy to standard therapy (antidepressive medication and / or psychotherapy). patients will receive 30 stimulation sessions in a 6-week treatment period (one session daily from monday to friday). follow up assessments are scheduled 1 and 3 months after end of treatment period.


Eligibility criteria:
inclusion criteria: * moderate or severe unipolar depression diagnosed according to criteria of diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) * duration of the current episode must be ≥ 6 weeks and ≤ 2 years * hdrs17 ≥ 18 * mild to moderate treatment resistance according to the antidepressant treatment history form \[athf-sf\]. treatment resistance is defined as having failed at least one but no more than three adequate antidepressant treatments in this episode * stable antidepressive medication 4 weeks before treatment or no antidepressive treatment * no further relevant psychiatric axis-i and/or axis-ii disorder except for anxiety disorders (according to dsm-5 and scid-5-pd) * no comorbid psychotic symptoms * ability to give consent exclusion criteria: * acute suicidality (madrs item 10 score \> 4) * antiepileptic drugs and/or benzodiazepines corresponding to \> 1mg lorazepam / day * history of brain surgery, significant and clinically relevant brain malformation or neoplasm, head injury, stroke, dementia or other neurodegenerative disorder * history of seizures * previous rtms treatment * lifetime history of non-response to adequate electroconvulsive therapy (minimum of eight treatments) * deep brain stimulation * cardiac pacemakers, intracranial implant, or metal in the cranium * substance dependence or abuse in the past 3 months (with the exception of tobacco) * severe somatic comorbidity as judged by the study physician * pregnancy

Keywords: major depression theta burst stimulation dorsolateral prefrontal cortex randomized sham-controlled multicenter