Kornimate/medical-research-clean huggingface dataset:
the effect of multiple-task training in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the activities of daily living requires the ability to perform multiple activities at the same time, not just the motor or cognitive activity. when many tasks are performed at the same time, the attention capacity is effectively used and attention is shared according to the difficulty and priority of the tasks. there is evidence that patients with multiple sclerosis (ms) have reduced performance during multitasking. in this study, the investigators aim to investigate the effect of multitasking training on balance, mobility, upper extremity performance and cognitive functions in patients with ms.

patients with ms between 0-1,5 score according to the extended disability status scale (edss) will be included in the study. the balance, mobility, upper extremity performance, the cognitive function will be evaluated twice. the study was designed as a prospective, randomized controlled study. the patients will be randomly assigned to three groups, the "multi-task training (mt)" group, the "single task training (st)" group, and "control" group. the training will be twice a week for 6 weeks. statistical analyses will be performed using the spss software version 15 (spss inc. chicago, il, usa). the pre-training and post-training measurements of groups will be compared with the wilcoxon test. the significance level was set at p\< 0.05

Eligibility criteria:
inclusion criteria: * participants who are ambulatory and volunteer to participate to the study, in a stable phase of the disease, without relapses in the last 3 month, with an edss between 0-1,5. exclusion criteria: * participants who have orthopedic, vision, hearing, or perception problems * patients who have any cardiovascular or pulmonary disease in which exercise is contraindicated

Keywords: multiple sclerosis multi-task training balance mobility cognition upper extremity function
role of ultrasonography in acute abdomen in adults in correlation to computed tomography scan

Conditions: Acute Abdomen; In Adults

Summary: the study aims to evaluate the role of ultrasonography in the diagnosis of the cause of acute abdominal pain in 50 adults presenting in the er at sohag university hospital and compares it to the computed tomography scan results of the same patients to discover the superiority of both over the other in the diagnosis of different acute abdomen cases.


Eligibility criteria:
inclusion criteria: * adults presented with acute abdominal pain. exclusion criteria: * less than 18 years old patients * pregnant women
performance and safety of the fixit® anchor in arthroscopic rotator cuff repair

Conditions: Rotator Cuff Injuries

Summary: verification of the performance and safety of the first row resorbable threaded anchor fixit® in arthroscopic rotator cuff repair non-interventional, prospective, non-comparative, multi-center study as part of the post-marketing follow-up of devices

the main objective of this study was to verify the safety of the resorbable threaded anchor fixit®, used in arthroscopic rotator cuff repair. this objective was to be imaging assessed (echography, mri) for the presence or absence of a rotator cuff re-tear and its degree of retractation. the second objective was to verify the performance of the fixit® anchor with 4 scoring criteria : constant score, pain score eva, quick dash score and bernageau classification

Eligibility criteria:
inclusion criteria: * patient with broken tendinopathy of the rotator cuff * patient over 18 years old * patient who has received complete medical information and not objecting to participate in research * social insured patient exclusion criteria: * pregnant or likely to be pregnant, or breastfeeding * patient under guardianship * non-cooperative patient, who does not want or is unable to follow the post-operative instructions (drug addict or alcoholic patient in particular)
nitrate, chronic obstructive pulmonary disease (copd) and exercise

Conditions: COPD

Summary: patients with moderate chronic obstructive pulmonary disease (copd) typically have reduced exercise capacity. this is because their lungs are damaged and because of increased work of breathing. in some patients, exercise capacity is reduced to such a level that even simple activities of daily living, such as washing and dressing, may impose a challenge. recent findings in healthy young people suggest that increasing the amount of nitrate in our diet in the form of beetroot juice can improve the ability to exercise. studies involving cycling have shown that less oxygen is needed to perform the same level of exercise after taking more nitrate in the diet. nitrate (found in abundance in beetroot) is known to be converted in the body to nitric oxide (no), a substance which increases blood flow and may affect the energy-producing mechanisms inside muscle cells. a recent exciting finding is that such dietary nitrate supplementation appears to reduce the amount of oxygen needed to complete moderate intensity exercise (walking) in healthy individuals. it is the purpose of this study to see if such effects could be seen in copd patients. if this is indeed the case, then it may suggest that a period of dietary supplementation of a relatively cheap, widely available, and natural food product may improve the ability of patients to undergo everyday tasks and ultimately improve their quality of life. to help investigators understand the effects of dietary nitrate supplementation on the ability to exercise in copd patients, the investigators will recruit 15 people with mild to moderate disease. they will complete a series of undemanding exercise tests on three separate occasions. on one occasion they will have had a course of nitrate rich beetroot juice leading up to the tests, and on the other occasion they will have had a course of beetroot juice with the nitrate removed. the investigators will monitor blood pressure, levels of nitrate and nitrite in the blood, oxygen uptake and functional capacity during the tests which will allow us to assess any effects that may have occurred as a result of increased nitrate intake.


Eligibility criteria:
inclusion criteria: * mild-moderate copd (fev1 30%-80% predicted values) * between the ages of 40-75 * able to give informed consent exclusion criteria: * uncontrolled hypertension (systolic bp\> 160mmhg, diastolic \>100mmhg) * regular therapy with organic nitrates, nicorandil and antibiotics. * current smoker (have smoked within the last 3 months) * chronic kidney disease (stage 4 or worse) * any other serious medical condition which would interfere with data interpretation and safety or that may make cycling exercise difficult, limited or uncomfortable.
single modality trans oral robotic surgery for primary oropharyngeal cancer: exploring the impact of surgical margins on local disease recurrence

Conditions: Head and Neck Squamous Cell Carcinoma

Summary: retrospective observational cohort study investigating single modality trans oral robotic surgery for primary oropharyngeal cancer: exploring the impact of surgical margins on local disease recurrence.

the storm study will examine transoral surgery performed before 31st july 2019. storm is a retrospective observational cohort study, involving international centres performing tors for primary opscc. the main aim of this study is to explore the impact of surgical margins on local disease recurrence in primary oropharyngeal squamous cell carci-noma treated with transoral robotic surgery (tors) without adjuvant therapy. the primary objective is to report local recurrence-free survival. the primary endpoint will be local recurrence-free survival time. the secondary objectives are to report overall survival, disease-specific survival and disease-free survival, and to report post-operative haemor-rhage rates. the secondary endpoints include overall survival time, dis-ease-specific survival time, disease-free survival time, post-operative haemorrhage time. exploratory objective to identify a clinically relevant cut-off for surgical margins as a predictor of local disease recurrence.

Eligibility criteria:
inclusion criteria: * 18 years and older. * primary opscc. * index cancer treated with tors without adjuvant therapy. * any post-operative tnm classification. * tors performed on or before 31st july 2019. exclusion criteria: * tors preformed for diagnostic or palliative intentions. * known distant metastasis at time of tors. * nasopharyngeal and thyroid cancers. * patients undergoing neoadjuvant or adjuvant chemotherapy, biotherapy, immunotherapy or radiotherapy to either the neck or primary site.

Keywords: primary opscc
antiemetic prophylaxis with fosaprepitant and ondansetron in patients undergoing thoracic surgery

Conditions: Postoperative Nausea and Vomiting; Anesthesia Complication; Thoracic Diseases

Summary: the goal of this clinical trial is to compare the efficacy, safety and feasibility of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in thoracicsurgery patients. participants will be randomized in a 1:1 ratio to the fosaprepitant and ondansetron group.the groups were analyzed and compared for frequency of vomiting in 24 h after surgery. in addition, we will further compare the occurrence of postoperative pulmonary complications, length of hospital stay, nutrition and quality of life after surgery in patients treated with different antiemetic prophylaxis.

postoperative nausea and vomiting (ponv) is a common postoperative complication of general anesthesia. the antiemetic 5-serotonin 3 (5-ht 3) receptor antagonist is widely used in postoperative anti-emesis,however, more clinical studies are needed to confirm whether neurokinin-1 (nk-1) receptor antagonists have better effects on ponv than 5-ht 3 receptor antagonists.we aimed to evaluate the effects of nk-1 receptor antagonists and 5-ht 3 receptor antagonists on ponv through a randomized controlled study. to this end, we took patients undergoing thoracic surgery as the research object, they received an antiemetic prophylaxis with ondansetron or fosaprepitant, and the frequency of postoperative nausea and vomiting the of the two antiemetic prophylaxis regimens were analyzed, and the occurrence of pulmonary complications, length of hospital stay, the nutrition and quality of life after surgery administration were also compared. through this clinical trial, we hope to obtain a better antiemetic prophylaxis regimen and provide clear information for patients and physicians to guide clinical decisions that enhance treatment efficacy and reduce the occurrence of side effects.

Eligibility criteria:
inclusion criteria: 1. aged between 18 and 70 years 2. physical status classified by the american society of anesthesiologists (asa) scale as i to iii 3. apfel score ≥ 2 4. undergoing thoracoscopic pneumonectomy exclusion criteria: 1. preoperative disorders of consciousness 2. body mass index (bmi) \> 35 kg/m2 3. occurrence of episodes of nausea or vomiting within 24 h prior to surgery、motion sickness,、previous ponv、people who smoke、people with alcoholism、use of corticosteroids, psychoactive or antiemetic drugs,、hypersensitivity to the study medications 4. serious kidney, liver, lung, heart, brain or bone marrow disease 5. conversion from thoracoscopic pneumonectomy to conventional pneumonectomy 6. participation in another clinical study.
the impact of memantine on electroconvulsive therapy (ect): will it improve response and protect against cognitive problems?

Conditions: Major Depressive Disorder

Summary: the purpose of this study is to determine whether memantine will enhance the therapeutic of effect on depression and prevent memory and other cognitive problems caused by ect.

patients will be assigned randomly either to a treatment group or a placebo groups. all patients in both groups will be receiving standard ect. the treatment group will receive memantine. all patients will be given a battery of cognitive tests and test of depression before ect treatments start, after the 6th ect treatment and after the completions of ect. an analysis will be performed to see if memantine causes any impact on the response to ect and prevents memory and cognitive impairment.

Eligibility criteria:
inclusion criteria: * meets criteria for major depressive disorder exclusion criteria: * neurological disease * mental retardation * seizure disorder

Keywords: electroconvulsive therapy memantine cognitive function memory
safety and efficacy of intracoronary ad5fgf-4 in patients with stable angina

Conditions: Stable Angina

Summary: the purpose of this study is to determine whether a single intracoronary infusion of ad5fgf-4 is effective in improving exercise capacity measured by exercise treadmill testing, angina functional class, patient symptoms, quality of life, and cardiovascular outcomes. to doses are to be studied, 2.87x10(8) and 2.87x10(9) viral particles, to evaluate the dose-response of ad5fgf-4. short-term and long-term safety of ad5fgf-4 will also be evaluated.


Eligibility criteria:
inclusion criteria: * ccs class ii - iv, technically unsuitable for revascularization by cabg or ptca able to exercise between 3 and 10 minutes on treadmill exclusion criteria: * unstable angina, ccs class 1 angina optimal candidates for revascularization

Keywords: angina fgf-4 angiogenesis adenovector growth factor myocardial ischemia revascularization
archery - artificial intelligence based radiotherapy treatment planning for cervical, head and neck and prostate cancer

Conditions: Cancer of Prostate; Cancer Head Neck; Cancer Cervix

Summary: the aim of this study is to look at whether an artificial intelligence (ai) based computer program can automate two components of the radiotherapy treatment pathway to a sufficient quality standard to enable its routine clinical use. the two components include the delineation (outlining) of anatomical areas that are at risk of tumour spread and at risk of radiation damage, and the definition of the position, size and shape of the radiation beams. the ai-based computer programs have been developed to perform tasks that would normally require direct human involvement by oncologists and medical physicists. proposed advantages include improved treatment accuracy, as well as a reduction in the time (from weeks to minutes) and human resources needed to deliver radiotherapy, which this study will test.


Eligibility criteria:
inclusion criteria: 1. consecutive patients with histologically confirmed head and neck cancers of the oropharynx, larynx, hypopharynx and nasopharynx (stage i-iii) that have given consent for radical radiotherapy. 2. consecutive histologically confirmed primary cervical cancer patients (stage ib-iiib including pelvic node positive) that have given consent for radical radiotherapy. 3. consecutive histologically confirmed primary prostate cancer patients (t1-4n0m0) that have given consent for radical radiotherapy. 4. mental capacity to understand and consent to participate in the study. 5. patients aged ≥18years. exclusion criteria: 1. patients requiring radiotherapy after curative surgery or surgery that is intended to remove as much of the tumour as possible. 2. patients receiving palliative radiotherapy 3. patients aged \< 18years.
algorithm for prophylactic mesh use in emergency laparotomy.

Conditions: Incisional Hernia of Midline of Abdomen

Summary: use of informed algorithm for patients selection of prophylactic mesh aplication after midline laparotomy in emergency surgery.

midline laparotomy complications have a high rate. when midline laparotomy is performed complications rate is even higher. one of the commons complications is incisional hernia, reaching up to 40%- 50% of cases in high risk groups. prophylactic mesh use has been proved to be useful preventing midline laparotomy in elective surgery. despite this, there is not enough data to recommend its use in emergency surgery. aim of the study is to investigate if use of an algorithm of informed decision for use of prophylactic mesh in emergency midline laparotomy reduces incisional hernia incidence. prospective cohort study of all consecutive midline laparotomy performed at our emergency surgery department. compare correct application of algorithm outcomes versus non correct application.

Eligibility criteria:
inclusion criteria: * emergency midline laparotomy. exclusion criteria: * surgical infection present at the moment of surgery. * ventrla or incisional hernia present at the moment of laparotomy . * open abdomen. * preoperative american society of anesthesiologist score (asa) of v.
hysteroscopic assessment of fallopian tubal patency

Conditions: Infertility; Menorrhagia

Summary: disease of the fallopian tubes is one of the most common reasons for infertility. the most common test, a hysterosalpingogram, tends to be painful,inconvenient, and frequently misses concurrent uterine disease. we propose using a less painful technique (through modified office hysteroscopy) for tubal assessment that can be performed in the office rather than hospital radiology and that uses gold standard technology for identifying coexisting uterine conditions.


Eligibility criteria:
inclusion criteria: 1. 18 - 50 years old 2. able to give consent 3. must have a uterus 4. must have documented negative testing for gonorrhea and chlamydia within the past year or previously negative when tested with a current partner in a monogamous relationship 5. negative test prior to procedure exclusion criteria: 1. pregnancy 2. active lower and upper genital tract infection 3. patients with allergies to hysterosalpingogram contrast will not be exposed to a contrast material to which they are allergic 4. premenarchal or postmenopausal 5. unable to read english at a 6th grade level or above 6. history of endometrial ablation 7. asherman's syndrome \> stage 1

Keywords: hysteroscopy
efficacy study of pharmacist intervention on medication-related problems in hemodialysis patients

Conditions: Renal Failure Chronic Requiring Hemodialysis

Summary: the investigators propose that pharmacist interventions would reduce the amount of unresolved medication-related problems in hemodialysis patients. condition:hemodialysis patients intervention:behavioral,pharmacist intervention study design:randomized allocation control: active control endpoint classification: efficacy study intervention model: parallel assignment masking: double blind (caregiver, outcomes assessor) primary purpose: treatment

introduction: end stage renal disease (esrd) incidence in taiwan ranked first and prevalence ranked second in the world from 2002 to 2005. several foreign researches had reported that hemodialysis (hd) patients often require 12 medications to treat 5 to 6 comorbid conditions. besides, esrd is a lifelong disease and rates of compliance may diminish overtime. thus, hd patients may be at particular risk for drug related problems, durg-drug interactions and noncompliance. our aim is to analysis the effect of pharmacist in medication-related problems in ambulatory hemodialysis patients. methods: this study is a randomized double-blind, active controlled trial. the investigators will invite and communicate with hd patients to find medication -related problems. after pharmacist evaluation, pharmacist will do pharmaceutical interventions to resolve medication-related problems, drug-drug interactions etc. in experimental group. in the active control group, pharmacist in this study will not do pharmaceutical interventions. the investigators will monitor each patient in a two-week period for medication-related problems. our primary outcome is the amount of unresolved medication-related problems in each group after two weeks. blind outcome assessor will evaluate the amount of unresolved medication-related problems in each case as well as compliance in these patients after two weeks. the investigators suppose that clinical pharmaceutical intervention will reduce the amount of unresolved medication-related problem in experimental group. on the other hand, patients without clinical pharmaceutical intervention will have more unresolved medication-related problems.

Eligibility criteria:
inclusion criteria: * 20-96 years old hemodialysis patient taking medications prescribed by nephrologists. exclusion criteria: * patients who refused informed consent * cognitive impaired * unable to talk or hearing disability

Keywords: hemodialysis pharmacist medication-related problems compliance
unstable fractures of the distal radius: trial of volar plate versus dorsal nail plate fixation

Conditions: Distal Radius Fractures

Summary: fractures of the distal radius are one of the most common orthopaedic injuries and are associated with a high complication rate. there is a lack of clinical trials comparing the different treatment modalities of fractures of the distal radius. the purpose of this randomized trial is to assess differences in functional outcome, radiological results, and complication rate in patients 55 years and older with an unstable displaced fracture of the distal radius without articular involvement treated with a dorsal nail plate or a volar plate.

surgical treatment is needed for distal radius fractures that can not be treated with a simple plaster cast, and is indicated in a substantial amount of these patients. there is a well known correlation between a good anatomical result and a good functional outcome for the patient. the most common methods for operative fixation are external fixation with a metal frame, percutaneous pin fixation, and open surgery with insertion of a metal plate and screws on the dorsal or the volar side of the fracture. biomechanical studies have shown differences in mechanical stability between different plate fixation systems. the investigators are conducting this randomized trial to investigate the differences in outcome after treatment with a dvr volar plate and a dnp dorsal nail plate. the dvr volar plate follows the same principles of fixation as other volar plates using locking screws and/or pegs. it has smooth or threaded pegs that are multidirectionally placed in the distal part of the plate. the dorsal nail plate (dnp) is a relatively new implant that is inserted through a less invasive technique, with a minimum of soft tissue exposure. it is inserted through a 3-4 cm long incision on the dorsal side of the wrist and is introduced into the medullary canal. it is fixed with screws on the proximal (nail) side of the fracture and threaded or smooth locked multidirectional pegs on the distal (plate) side of the fracture. it has been suggested as a good alternative to regular plate fixation where less invasive surgery is desired. clinical patient series have been published showing good clinical results. there are no clinical trials comparing these two types of treatment. therefore the investigators want to conduct a randomised controlled trial, with the purpose of finding potential differences in functional outcome for the patients.

Eligibility criteria:
inclusion criteria: * unstable dorsally displaced fracture of the distal radius without articular involvement * age 55 years or older exclusion criteria: * previous fracture of the same wrist * more than one acute fracture (except the ulnar styloid process) * open fracture * mental impairment or unable to understand and sign an informed consent * fracture older than 14 days

Keywords: fracture radius surgery osteosynthesis