Kornimate/medical-research-clean huggingface dataset:
impact of pneumococcal conjugate vaccines on otitis media and acute otitis media in swedish children

Conditions: Acute Otitis Media; Otitis Media

Summary: the goal of this study is to look at the effect of pneumococcal conjugate vaccines (pcv) on physician-diagnosed otitis media (om) and acute otitis media (aom) incidence in swedish children by collecting and analyzing patient level observational data already available in existing regional and national databases.


Eligibility criteria:
inclusion criteria: data from all children ≤ 5 years old in vgr and skåne in each year during the study period (2004 - 2013) exclusion criteria: not applicable

Keywords: otitis vaccine sweden database
accelerated aging in middle-aged men with sleep-disordered breathing.

Conditions: Obstructive Sleep Apnea

Summary: obstructive sleep apnea syndrome (osas) regardless of any other associated risk factor can lead to accelerated aging. the study of aging-related obstructive sleep apnea (osa) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. the investigators propose to compare a group of osas patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (bmi)


Eligibility criteria:
inclusion criteria patient: * men aged 20 to 65 years * having polysomnography in the functional explorations department, sleep laboratory, hospital henri mondor, creteil * with an ahi \> 5 / h healthy volunteers: * men aged 20 to 65 years * with an ahi ≤ 5 / h exclusion criteria all subjects: * known cardiovascular risk: hypertension treated, diabetes treated, dyslipidemia treated, * known cardiovascular disease associated (heart failure, rhythm disorder ...) * known respiratory diseases * known neoplastic pathology, known chronic inflammatory disease * psychiatric pathology treated * medication * not affiliated to the french social health care system * major protected person * private person of liberty * people in emergency situation * patient refusing to participate in the study

Keywords: obstructive sleep apnea aging telomere length
evaluation of long-term immunogenicity of a boost dose of mva-bn vaccine

Conditions: Monkeypox

Summary: this study is to evaluate the long-term immunogenicity of a boost dose of mva-bn vaccine

mpox is an endemic zoonosis in africa, caused by the mpxv virus of which there are two clades: i (former congo basin) and ii (former west africa). since 2022, clade ii has emerged globally via sexual transmission, primarily among men who have sex with men (msm), resulting in a declaration of public health emergency (pheic) by the who. in 2023, a clade i epidemic emerged in east africa with a high case fatality rate (3-5%). in august 2024, the who again declared a pheic after the spread of clade i to african countries with no previously reported cases and outside africa, raising fears of higher mortality and transmission. a 3rd generation vaccine, mva-bn (imvanex® /jynneos®), initially developed against smallpox, was approved in 2022 to prevent mpox. in france, the has recommends post- and pre-exposure vaccination for populations at risk: msm, trans people with multiple partners, sex workers and certain professionals. for people born before 1980 (history of smallpox vaccination), a single dose is recommended as primary vaccination, while immunocompromised subjects require 3 doses. data show vaccine effectiveness of 20-80% in post-exposure prophylaxis (pep) and \~80% in pre-exposure but neutralizing antibodies become undetectable after one year. since the summer of 2024, the has has recommended a booster dose 2 years after the primary vaccination, on the basis of immunogenicity studies showing an increase in seroconversion to 98.7% one month after administration, but underlines the need to have other data, in particular on the durability of this response. a study is proposed in msm on hiv prep (pre-exposure prophylaxis), a priority population for structured medical monitoring, to evaluate the immunogenicity and safety of the mva-bn booster in this context.

Eligibility criteria:
inclusion criteria: * men aged over 18 years * have received two doses of mva-bn vaccine as an initial schedule * eligible for a booster dose of mva-bn (according to the has recommendation) * be eligible and wish to initiate prep-hiv treatment or be followed for prep-hiv treatment * covered by social security (excluding ame) exclusion criteria: * history of mpox (virologically confirmed) * be under guardianship or curatorship * be subject to a judicial protection measure * have a contraindication to vaccination against mpox

Keywords: monkeypox mva-bn booster vaccine hiv pre-exposure prophylaxis
microrna activation of lox-1 mechanisms in endometriosis

Conditions: Endometriosis

Summary: endometriosis is a disorder that occurs in women. with endometriosis, tissue that should be found in the womb is found in sites outside of the womb. this disorder impairs the function of the cells that line the body's blood vessels (endothelium). the endothelium helps to control blood flow in healthy vessels. women with this disorder have an increased risk for high blood pressure and high cholesterol. they have a higher risk for cardiovascular disease, too. with this study, we will learn how endometriosis impairs the lining of blood vessels and increases the risk for disease.

epidemiologic data demonstrate a clear association between endometriosis, reproductive risk factors, inflammation and cardiovascular (cv) risk. circulating factors, low-density lipoprotein (ldl) and oxidized ldl (oxldl), are two of many biomarkers of cardiovascular and inflammatory disease of endometriosis. an important signaling mechanism through which circulating ldl and oxldl act is the lectin-like oxidized ldl receptor (lox-1). lox-1 signal transduction functionally results in pronounced endothelial dysfunction, a hallmark of cv. we hypothesis that one factor mediating the elevated risk of cardiovascular disease in endometriosis is microrna (mirna) activation of lox-1 receptor mechanisms. specific aim 1. to test the hypothesis that lox-1 receptor activation is increased leading to endothelial dysfunction in endometriosis. specific aim 2. to test the hypothesis that decreased micrornas (i.e. let7-a, let7-b, let7-g, mir98, mi590-p) are driving increased lox-1 receptor expression and function in endometriosis.

Eligibility criteria:
inclusion criteria: * women between the ages of 18 and 45 years with endometriosis (diagnosis by prior laparoscopy by subject's own physician \<5 years prior, and reported by the subject to the researchers) exclusion criteria: * use of nicotine-containing products (e.g. smoking, chewing tobacco, etc.) * diabetes (hba1c .6.5%) * bp\>140/90 * taking pharmacotherapy that could alter peripheral vascular control (e.g. insulin sensitizing, cardiovascular medications) * pregnancy * breastfeeding * taking illicit and/or recreational drugs * abnormal liver function * rash, skin disease, disorders of pigmentation, known skin allergies * diagnosed or suspected metabolic or cardiovascular disease * persistent unexplained elevations of serum transaminases * known allergy to latex or investigative substances

Keywords: skin blood flow cholesterol statin intradermal microdialysis
evaluating mindfulness-based interventions with new fibromyalgia patients

Conditions: Fibromyalgia

Summary: the purpose of this study is to study the feasibility of a wearable brain sensing wellness device to provide mindfulness training to fibromyalgia patients who have failed medical therapy.

all study participants will receive a wearable brain sensing wellness device, and demonstration of the mindfulness sessions. participants will be asked to complete study surveys/questionnaires. during the first part of study, participants will be asked to complete the intervention. after completion of the intervention they will enter a follow-up phase, where they will be contacted and asked to complete surveys and gauge satisfaction with the study.

Eligibility criteria:
inclusion criteria: * 18 years of age or older at time of consent. * diagnosed with fibromyalgia. * not pregnant by subject self-report at time of consent. * have the ability to provide informed consent. * have the ability to complete all aspects of this trial. * have access to a iphone, ipad, android device. * has no contraindicating comorbid health condition as determined by the clinical investigators. exclusion criteria: * used or been enrolled in any treatments for fibromyalgia, or pain within the past 30 days. * used an investigational drug within the past 30 days. * currently (within the past 3 weeks) been practicing mindfulness training on a weekly/regular basis. * currently (within the past 3 weeks) been undergoing an additional program (e.g. cam) to improve quality of life. * currently (within 3 weeks) been enrolled in another clinical or research program (e.g. cam) which intervenes on the patients' qol, or stress. * an unstable medical or mental health condition as determined by the physician investigator.
using the hunt motivational scale to aid in weight loss and weight maintenance

Conditions: Weight Loss

Summary: in this study, we plan to determine the efficacy of the hunt motivational scale as a tool for weight loss compared to standard of care in the penn medicine princeton health weight management program.

obesity is rising at alarming rates, currently at nearly 40%. there are very few tools, specifically questionnaires, for healthcare providers to help their patients lose weight or maintain their weight loss. the hunt motivational scale is one such tool to help patients identify areas that need improvement in order to aid in weight loss and weight maintenance. the hms is designed to motivate patients to track, plan, and practice other healthy weight loss and weight maintenance practices so that they will have success. in this study, approximately 75 subjects in the penn medicine princeton health weight management program will be randomly assigned to either receive the hms or not (standard of care). they will be followed for a period of six months at the end of which it will be determined whether the group that received the hms lost more weight than the control group.

Eligibility criteria:
inclusion criteria: * patient in weight management program at penn medicine princeton health exclusion criteria: * does not have a visit every three to four weeks * not in active weight loss phase of the program * diminished intellectual capacity to complete questionnaire i.e. down's syndrome
tau vs m-sbirt in primary care

Conditions: Substance Use Disorders

Summary: the goal of this research is to leverage technology in primary care clinics to improve screening, brief intervention and referral to substance use disorder (sud) treatment, and treatment attendance by comparing 1. a text message-based screening, phone-based brief intervention, and referral to treatment by a remote care coordinator (m-sbirt; intervention arm), versus 2. evidence-based, in-person screening, brief intervention, and referral to treatment (sbirt; treatment as usual (tau); control arm). primary aim is to compare the efficacy of m-sbirt to tau in positive screens for substance use. secondary aim is to compare m-sbirt to tau on substance use treatment attendance.

this research study is looking at the use of technology in primary care clinics and seeing if it improves screening, brief intervention and referral to substance use disorder (sud) treatment, and attendance to treatment. to do so the study, investigators will be comparing a text message based substance use screening and treatment program, called mobile screening, brief intervention, and referral to treatment (m-sbirt) to standard of care screening, brief intervention and referral treatment which traditionally takes place in-person. patients at the musc bee street primary care clinic between the ages of 18-75 may be eligible.

Eligibility criteria:
inclusion criteria: * age 18-75 * attended a primary care visit at the musc family medicine clinic on bee st * english fluency * owner of a cell phone with sms text-message based capability * access to wifi * a device to allow audio and video teleconferencing if completing informed consent remotely * able to provide informed consent. exclusion criteria: - none

Keywords: substance use disorders social determinants of health screening, brief intervention, referral to treatment (sbirt) telehealth mobile sbirt (m-sbirt) primary care
screening brain mri in high school football: does the guardian cap reduce the risk of traumatic brain injury

Conditions: Brain Concussion; Brain Injuries; Diffuse Axonal Injury; Athletic Injuries; Injury, Brain, Traumatic

Summary: screening brain magnetic resonance imaging (mri) with fluid-attenuated inversion recovery (flair) and susceptibility weighted imaging (swi) sequences will be performed pre and post season on high school football players. one set of players will wear the guardian cap on their five star rated helmets and the other will wear five star rated helmets only. the investigators will compare outcomes of impact scores and mri findings between the two groups to see if there is a statistical difference in reduction of injury and to establish what the baseline level of mri findings related to injury from high school football is as well as what the baseline level of injury is prior to the start of the season.

screening brain magnetic resonance imaging (mri) with fluid-attenuated inversion recovery (flair) and susceptibility weighted imaging (swi) sequences will be performed pre and post season on high school football players. one set of players will wear the guardian cap on their five star rated helmets and the other will wear five star rated helmets only. the investigators will compare outcomes of impact concussion scores and mri findings on flair and swi sequences between the two groups to see if there is a statistical difference in reduction of mri findings on flair and swi sequences or adverse impact concussion score outcomes and to establish what the baseline level of mri findings on flair and swi sequences related to injury from high school football is as well as what the baseline level of mri findings on flair and swi is prior to the start of the season.

Eligibility criteria:
inclusion criteria: * high school football players willing and able to have a pre and post season brain mri with flair and swi sequences and wear the guardian cap on their helmet exclusion criteria: * high school football players unwilling or unable to have an mri

Keywords: brain concussion brain injuries diffuse axonal injury football head protective devices magnetic resonance imaging helmet third party add-on
does a ketogenic diet causes ketosis in patients on intensive care?

Conditions: Ketosis

Summary: the purpose of this study is to assess if an enteral ketogenic feed will cause a ketotic state in critically ill patients on intensive care.

this pilot study is a prospective, single-centre, unblinded, parallel-group, randomised controlled, phase iib trial comparing standard enteral nutrition with an enteral ketogenic feed. the trial has a simple, pragmatic design and will be analysed on an intention-to-treat basis. it aims to recruit 10 patients from a single university teaching hospital adult general icu. the anticipated recruitment period is 4 weeks. adult patients admitted to intensive care and expected to require enteral feed via a nasogastric tube for at least 5 days and who fulfil other eligibility criteria will be allocated at random to receive either standard feed (nutrison protein plus multi fibre) or a ketogenic enteral feed (nutrison ketocal 4:1). the primary endpoint will be increase in ketone body concentration in serum. secondary endpoints will include, time taken to achieve a ketotic state, ketone levels in critical care patients who are not absorbing enteral feed, glucose levels in patients on a ketone feed, triglyceride and cholesterol levels, creatinine kinase levels and development of a metabolic acidosis. adult icu patients will be eligible to be included in this study if they are expected to require enteral feed via a nasogastric or nasojejunal tube or established percutaneous jejunostomy for at least 5 days. practically, this will be achieved by screening ventilated patients as they will require enteral feeding major exclusion criteria include contraindications to ketogenic feeds, contraindications to enteral feeding, a new (\< 5 days) percutaneous jejunostomy. the intervention will continue until 14 days if the patient still requires enteral nutrition or until able to commence a normal diet orally.

Eligibility criteria:
inclusion criteria: * adults who require mechanical ventilation within 72 hours of admission to intensive care exclusion criteria: * known intolerance to the ketogenic diet * contraindication to standard protocolised enteral feeding * pregnancy * severe liver disease (known decompensated liver cirrhosis, previous liver transplant, acute hepatitis (bilirubin \>100, alt \>500) * severe metabolic acidosis (ph \< 7.2, hco3 \< 15mmol/l) that has not been corrected prior to enrolment in the study * patients predicted to stay less than 24 hours on intensive care

Keywords: ketone bodies enteral nutrition ketogenic diet
newborn thermal care practices: a community based program to prevent hypothermia

Conditions: Hypothermia

Summary: the purpose of this study is to train mothers/caretakers on how to prevent their babies from becoming too cold.

this study is designed to determine domiciliary care knowledge, attitudes and practices regarding essential newborn care, with a focus on newborn thermal control; develop behavior change communications to promote prevention, early recognition and effective management of newborn hypothermia, evaluate impact and cost-effectiveness of education/behavior change communications delivered by community health workers and community health promoters/change agents on essential newborn care practices, including care-seeking; prevalence, recognition and management of hypothermia, including adaptation, safety and utility of kangaroo mother care; and neonatal morbidity and mortality; evaluate the feasibility and acceptability of using lct thermospot device in rural communities to enhance mothers' recognition and management of neonatal hypothermia; determine the influence of the neonatal hypothermia indicator (thermospot) on recognition of and response to newborn hypothermia and health-seeking behavior of the caregivers; develop algorithms for recognition and management of hypothermia to inform neonatal imci and verbal autopsy protocols and gain insight into the potential roles of various cadres of workers in providing neonatal health services at the community level and inform the development of models of community-based essential newborn care.

Eligibility criteria:
inclusion criteria: * uttar pradesh * newborns at home exclusion criteria: * hospitalized babies

Keywords: hypothermia newborn india maternal/child health infant kangaroo mother care
development of clinical method to triclosan retention in plaque following brushing

Conditions: Dental Plaque

Summary: the objective is to develop a method to determine active ingredient uptake in oral care products.


Eligibility criteria:
inclusion criteria: * male or female volunteer 18 - 65 years of age (inclusive). * good general health with a minimum of twenty (20) natural, uncrowned teeth (excluding third molars) * able and willing to sign the informed consent form. * plaque score of at least 1.5 on the modified quigley-hein plaque index. * no known history of allergy to personal care/consumer products or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study exclusion criteria: * medical condition which requires pre-medication prior to dental procedures/visits * medical condition which precludes not eating/drinking for 2 hours * advanced periodontal disease (gum disease) * 5 or more decayed, untreated dental sites (cavities) * diseases of the soft or hard oral tissues * orthodontic appliances * abnormal salivary function * use of drugs that can affect salivary flow * use of antibiotics one (1) month prior to or during this study * use of any over the counter medications other than analgesics (i.e. aspirin, ibuprofen, acetaminophen, naproxyn, etc) * pregnant or breastfeeding. * participation in another clinical study in the month preceding this study * immune compromised individuals (hiv, aids, immuno suppressive drug therapy)
tobacco use intervention among radiation oncology patients

Conditions: Tobacco Use Disorder

Summary: tobacco prevention and intervention strategies in the general population are ongoing and evolving. however, strategies to help cancer patients overcome tobacco dependence have been limited. radiation oncology patients who continue to smoke despite their cancer diagnosis have a lower quality of life (qol), increased frequency and severity of side effects during their cancer treatment, higher risks of developing a smoking-related primary cancer, and may have a poorer survival rate than their non-smoking counterparts. these are all compelling reasons to be more pro-active in helping cancer patients stop smoking. the overall objective of this project is to adapt a model of an effective tobacco use intervention that can be delivered by any trained radiation oncologist and their staff.


Eligibility criteria:
inclusion criteria: * at least 18 years of age; * current cigarette smoker (smoked any cigarettes within the previous 7 days prior to their first visit) or recent ex-smoker (last cigarette smoked was \>7 but ≤ 30 days); * planning to undergo radiation therapy (rt) that is to be delivered by the members of the department of radiation oncology in rochester, mn; * be receiving a minimum of 5 weeks of rt and/or be willing to return for all 5 sessions. exclusion criteria: * patient is currently (in previous 30 days) using other formal behavioral tobacco cessation program \[i.e., behavioral therapy (nicotine dependence consultation and treatment) or telephone quitline\]; * daily use of tobacco products other than cigarettes; * hospitalized patients; * karnofsky performance status (kps) score of \< 60 (kps = 60 corresponds to a person who requires occasional assistance but is able to care for most of their own needs; * presence of an unstable or untreated psychiatric disorder.

Keywords: tobacco use cessation radiation oncology smoking
postoperative noninvasive ventilation after upper abdominal surgery in chronic obstructive lung disease

Conditions: Acute Respiratory Failure Post Surgical (Diagnosis)

Summary: in qena university hospital a prospective, randomized study was carried out on 100 copd patients, all were divided into; conventional therapy without niv (c group) 50 patients or with prophylactic niv(n group) 50 patients.niv applied for approximately 30 to 45 min at 2- to 4-h intervals for 48 h following surgery . primary endpoint was the acute respiratory events (are) .secondary endpoints were acute respiratory failure (arf), intubation rate, mortality rate, infectious and non-infectious complications, and icu stay.


Eligibility criteria:
1. inclusion criteria: * age˃18 years, scheduled for upper abdominal surgery under general anesthesia. * moderate to very severe copd (gold ii to iv). * asa functional status ii or greater. 2. exclusion criteria: * contraindications to the application of niv. * sleep apnea syndrome. * facial deformation. * inability to follow the study.

Keywords: noninvasive ventilation copd acute respiratory failure