Kornimate/medical-research-clean huggingface dataset:
modified suanzaoren decoction versus eszopiclone for the treatment of chronic insomnia disorder

Conditions: Chronic Insomnia Disorder

Summary: the purpose of this study is to observe the cognitive function and clinical efficacy of modified suanzaoren decoction and eszopiclone in the treatment of chronic insomnia disorder patients, and to investigate the possible neural mechanisms using mri techniques.

the subjects were enrolled and divided into two treatment groups using the randomized numeric table method. each group received either modified suanzaoren decoction or eszopiclone treatment for a period of 4 weeks. general demographic data were collected, and changes in sleep, mood, cognitive function, and rs-fmri before and after treatment were observed. assessment tools included the pittsburgh sleep quality index (psqi), insomnia severity index (isi), hamilton anxiety scale (hama), and hamilton depression scale (hamd) for subjective measures, as well as the repeatable battery for the assessment of neuropsychological status (rbans) and polysomnography (psg) for objective evaluation.

Eligibility criteria:
inclusion criteria: * have adequate comprehension ability, with at least 9 years of education. * western medical diagnosis criteria (meeting the diagnostic criteria for chronic insomnia disorder in icsd-3). * patient's subjective dissatisfaction with either the total duration or quality of sleep: difficulty falling asleep, difficulty maintaining sleep, or early awakening. * frequency of sleep problems: occurring at least 3 nights per week, and persisting for at least 3 months. exclusion criteria: * individuals who have used sedatives or hypnotics, or psychiatric medications in the week prior to enrollment. * individuals who regularly consume strong tea, have a high smoking volume, or are dependent on coffee. * women who are pregnant or breastfeeding. * patients with severe primary diseases such as severe cardiovascular and cerebrovascular diseases, other mental disorders, or severe obstructive sleep apnea syndrome. * individuals with allergies or multiple drug allergies.

Keywords: suanzaoren decoction eszopiclone polysomnography
intraoperative transesophageal echocardiography assessment of portal vein flow and renal resistive index as a predictor of acute kidney injury after cardiac surgery: a prospective observational study

Conditions: AKI

Summary: the purpose of this study is to better understand if transesophageal echocardiography during cardiac surgery can predict problems with kidney function after cardiac surgery.

informed consent will be obtained prior to surgery. preoperative demographic and baseline clinical data will be collected. we will assess the patient's risk of postoperative aki using the validated cleveland clinic score based on preoperative risk factors and calculate the european system operative score risk evaluation score (euroscore ii). after standard anesthesia induction and intubation, a tee probe will be inserted by a cardiac anesthesiologist, who is certified in intraoperative echocardiography. we will use a standard ultrasound machine (epiq 7 philips;philips, bothell, wa). images of the right or left kidney along with doppler flow and velocities will be obtained prior to cardiopulmonary bypass (cpb), after cpb, and after chest closure. images of the portal vein with doppler flow and velocity will be obtained prior to cpb, after cpb, and after chest closure. vitals signs and hemodynamic data will be collected concurrently during these times. (see data sheet) concurrent ecg will be obtained to identify the phases of the cardiac cycle. mean arterial pressure (map) will be maintained within 20% of baseline map with bolus or continuous infusion of vasopressors (phenylephrine, norepinephrine, epinephrine, vasopressin, ephedrine). cardiopulmonary bypass management will be standard, with target systemic blood flow of 2.4l/min/m2. postoperative data will include urine output, serum creatinine, calculated gfr (using modification of diet in renal disease \[mdrd\] method) hospital and icu length of stay, and 30-day mortality.

Eligibility criteria:
inclusion criteria: * inclusion criteria are patients \>18 years old getting elective cardiac surgery with the use of cardiopulmonary bypass at the university of chicago medical center. exclusion criteria: * exclusion criteria are preexisting renal insufficiency/failure (glomerular filtration rate \< 60 ml/min/1.73 m2 \[stage 2 chronic kidney disease\] or dialysis, renal vein thrombosis, renal artery stenosis, significant aortic regurgitation (moderate to severe aortic regurgitation on preoperative or intraoperative tee), liver cirrhosis, portal vein thrombosis, preoperative intra-aortic counterpulsation balloon pump, emergency surgery, inability to obtain flow velocity waveforms of renal/portal vasculature on tee, and kidney or liver transplant.

Keywords: transesophagel echocardiography cardiac surgery kidney function
randomized-controlled trial (rct) on cpap-withdrawal and microvascular function in osa

Conditions: Obstructive Sleep Apnoea

Summary: randomized controlled trial (therapeutic vs. placebo cpap) including 46 patients with obstructive sleep apnea (osa) to define the physiological effects of continuous positive airway pressure (cpap) therapy withdrawal on myocardial perfusion and dermal and renal microvascular function during a 2 week period.


Eligibility criteria:
inclusion criteria: * objectively confirmed osa (at the time of original diagnosis) with an oxygen desaturation index (odi, =4% dips) of \>20/h and an ess of \>10. * currently \>20/h oxygen desaturations (=4% dips) during an ambulatory nocturnal pulse oximetry performed at the end of a 4-night period without cpap. * treated with cpap for more than 12 months, minimum compliance 4h per night, ahi\<10 with treatment (according to cpap machine download data). * current ess \<10. exclusion criteria: * previous ventilatory failure (awake spo2 \ 6kpa). * unstable, untreated coronary or peripheral artery disease, severe arterial hypertension or hypotension (\>180/110 or \<90/60mmhg) * previously diagnosed with cheyne-stokes breathing. * current professional driver; any previous sleep related accident. * age \ 75 years at trial entry. * acute inflammatory disease
two-field versus three-field lymphadenectomy in thoracic esophageal carcinoma without cervical lymph node involvement

Conditions: Esophageal Cancer

Summary: the purpose of this study is to compare the lymph node dissection results and prognosis in thoracic esophageal carcinoma patients without cervical lymph node involvement by preoperative ct and/or ultrasound treated by two-field lymphadenectomy or three-field lymphadenectomy.another purpose of this study is to clarify whether the lymph node along the right recurrent laryngeal nerve can be taken as the sentinel lymph node which is able to indicate neck lymph node metastasis and necessity for three-field lymphadenectomy.

esophageal carcinoma is a prevalent and aggressive malignant disease with poor prognosis in china. complete surgical resection with systemic lymph node dissection remains the most effective treatment method for this malignancy. although tree-field lymph node dissection was reported to be effective in improving long-term survival in japan,there is no enough evidences yet to demonstrate that three field lymph node dissection is superior to two field lymph node dissection in reducing postoperative recurrence and improving long-term survival. in this study, the dissection of lymph node adjacent to the right recurrent laryngeal nerve would be performed and examined routinely by intraoperative frozen-section. if the lymph node is positive, three field lymph node dissection(cervical-thoracic-upper abdominal lymphadenectomy) will be performed, if negative, the patients will be randomly assigned either to three-field lymphadenectomy group or two-field lymphadenectomy group. the purpose of this large scale multi-center trial is to compare the lymph node dissection results and prognosis in thoracic esophageal carcinoma without cervical lymph node involvement treated by three-field lymphadenectomy or two-field lymphadenectomy and clarify whether the lymph node along the right recurrent laryngeal nerve could be taken as sentinel lymph node indicating neck lymph node metastasis and necessity of three-field lymphadenectomy.

Eligibility criteria:
inclusion criteria: 1. patients with histologically confirmed squamous cell esophageal cancer, without any previous anti-tumor therapy; 2. preoperative clinical tnm stage：ct1b-3n0-1m0; 3. adequate cardiopulmonary, liver, brain and kidney functions for esophagectomy either via right thoracotomy or vats; 4. no evidence of suspicious neck lymph node metastasis (ln short diameter \< 0.8cm or ln short/long diameter \<0.65 by cervical ct and/or ultrasound); 5. willing to participate the clinical trial and sign the informed consent before being enrolled into clinical trail exclusion criteria: 1. previous use of anti-cancer therapy; 2. preoperative clinical tnm stage: n2-3 or m1; 3. inadequate cardiopulmonary,liver, brain and kidney function for surgery; 4. previous malignancy history. 5. suspicious neck lymph node metastasis (ln short diameter ≧0.8cm or ln short/long diameter ≧0.65 by cervical ct and/or ultrasound); 6. unwilling to participate the clinical trial and refuse to sign informed consent.

Keywords: without cervical lymph node involvement
effect of an individual counseling session on physical activity level of individuals with copd

Conditions: COPD

Summary: the goal of this randomized clinical trial is to study the effect of an individual counseling session on the level of physical activity and motivation to practice physical exercise in individuals with copd. the main question\[s\] it aims to answer are: • does a counseling session improve the level of physical activity and motivation to practice physical exercise in individuals with copd? participants will perform a respiratory rehabilitation program (control group, cg) and a respiratory rehabilitation program and the counseling session (experimental group, eg). researchers will compare eg to cg to see if there is any difference in physical activity level and motivation to exercise between groups.


Eligibility criteria:
inclusion criteria: * portuguese nationality; * medical diagnosis of copd according to global initiative for chronic obstructive lung disease (gold 2022); * aged over 40 years. exclusion criteria: * underwent recent orthopedic surgeries (\<3 months); * pregnant; * terminal illness diagnosis (life expectancy of less than 6 months); * high cardiovascular risk classification for the practice of physical activity according to american college of sports medicine (acsm 2018).

Keywords: copd pulmonary rehabilitation physical activity counseiling session exercise
immunogenicity and safety of a booster dose of monovalent glycoprotein-conjugated (diptheria toxin -crm197) hib vaccine in 365-569 days old healthy infants

Conditions: Haemophilus Influenzae Type b (Hib) Infection

Summary: this study will evaluate the safety and immunogenicity of booster dose of two commercially available vaccines used to prevent haemophilus influenzae type b infections in children 365-569 days of age


Eligibility criteria:
inclusion criteria: * infants 365-569 days of age. exclusion criteria: * subjects who already received a booster dose of hib vaccine. * history of serious reaction(s) following vaccination. * any vaccination within 7 days of study vaccination. * known or suspected immune impairment.

Keywords: haemophilus influenzae type b (hib) vaccine anti-prp antibody
clinical research on the efficacy of thread-embedding acupuncture on herniated intervertebral disc of lumbar spine

Conditions: Lumbar Disc Herniation

Summary: this clinical trial is designed to evaluate the efficacy and safety of thread-embedding acupuncture for treatment of lumbar herniated intervertebral disc (l-hivd) by assessing pain, function, and quality of life.

seventy patient between the ages of 19 and 70 with l-hivd will be recruited by eligibility criteria and randomly allocated to the thread-embedding acupuncture (tea) group and sham thread-embedding acupuncture (stea) group. both groups will receive treatment on predefined 23 acupoints once a week for 8 weeks, and needle with thread removed will be used in stea group instead of normal tea. 100 mm visual analogue scale (vas) for low back pain will be assessed as a primary outcome. also, 100mm vas for radiating pain, oswestry disability index (odi), rolland morris disability questionnaire (rmdq), eq-5d-5l and global perceived effect (gpe) will be measured as secondary outcomes. all the outcomes will be assessed at baseline, 4 weeks after screening, treatment end (8 weeks, primary end point) and follow-up sessions (12 and 16 weeks).

Eligibility criteria:
inclusion criteria: 1. male or female adults aged 19-70 2. radiating pain matched with severer abnormality than bulging shown by ct or mri on lumbar spine 3. 40 or higher low back pain on 100mm pain vas 4. volunteers who agree to participate and sign the informed consent form, following a detailed explanation of clinical trials exclusion criteria: 1. congenital abnormalities or surgical history on lumbar regions 2. red flag signs that may be suspected of cauda equina syndrome, such as bladder and bowel dysfunction or saddle anesthesia 3. tumor, fracture or infection in lumbar regions 4. injection treatment on lumbar regions within 1 week 5. psychiatric disorder currently undergoing treatment such as depression or schizophrenia 6. inappropriate condition for thread-embedding acupuncture due to skin disease or hemostatic disorder (pt inr \> 2.0 or taking anticoagulant) 7. other diseases that could affect or interfere with therapeutic outcomes, including severe gastrointestinal disease, cardiovascular disease, hypertension, diabetes, renal disease, liver disease or thyroid disorder 8. contraindication of acetaminophen including intercurrent disease, hypersensitivity reaction or other medication 9. pregnant women or other inappropriate condition for thread-embedding acupuncture 10. heavy drinking (more than 3 cups per day) that could cause hepatotoxicity with acetaminophen

Keywords: thread-embedding acupuncture herniated intervertebral disc of lumbar spine low back pain radiculopathy
effects of pioglitazone on stress reactivity and alcohol craving (pilot)

Conditions: Alcohol Use Disorder

Summary: the purpose of this study is to assess the effect of pioglitazone on stress- and alcohol-related measures in treatment-seeking individuals with alcohol use disorder (aud) and elevated levels of stress and anxiety.


Eligibility criteria:
inclusion criteria: * treatment-seeking individuals diagnosed with aud diagnostic statistical manual 5 (dsm-5) * fluent in english * past month excessive alcohol use (\>7 drinks/week for woman, \>14 drinks/week for men, \>3 drinks/occasion for women\>4 drinks/occasion for men)14 * baseline hamilton anxiety rating scale (ham-a) or perceived stress scale (pss) core indicative of mild to moderate anxiety (score 8 to 23) or moderate stress (score 14 to 26), respectively * increase in alcohol craving following the baseline stress reactivity assessment. exclusion criteria: * individuals will be excluded for exhibiting severe scores on the ham-a, pss, or post-traumatic (ptsd) checklist (pcl-5) at the discretion of the admitting physician * physical dependence on alcohol alcohol use disorders inventory (audit) score indicative of severe alcohol dependence (≥13 for women, ≥15 for men) * greater than mild substance use disorder on drugs other than alcohol, nicotine, and marijuana * contraindications for taking pioglitazone; medical conditions contraindicating pioglitazone pharmacotherapy or taking contraindicated medications * be pregnant, nursing, or planning on becoming pregnant during the course of the study * have any other illness, condition, or use of medications, which in the opinion of the pi and/or admitting physician would preclude safe and/or successful completion of the study.

Keywords: alcohol pioglitazone stress anxiety
voiding disorders in children after sacrococcygeal teratoma resection

Conditions: Sacrococcygeal Teratoma; Neurogenic Bladder; Voiding Disorders

Summary: sacrococcygeal teratomas are the most common neonatal tumors and require rapid and complete resection. tumor nerve compression and pelvic surgical sequelae may lead to many and varied voiding disorders. data concerning long-term vesico-sphincteric disorders are conflicting. some studies find good functional results \[cozzi et al., 2008; draper et al., 2009\]. however other authors reveal neurologic bladder with detrusor sphincter dyssynergia \[hambraeus et al., 2018\] and rise concerned about long-term renal function \[khanna et al., 2019; rehfuss et al., 2020\] even in the absence of clinical voiding disorders. most of studies include young patients with other malformations such as anorectal malformations or dysraphisms which may impact the results. the main objective is to assess bladder dysfunction in children aged 6 to 18 years after isolated sacrococcygeal teratoma resection.


Eligibility criteria:
inclusion criteria: * children aged 6 to 18 * history of sacrococcygeal teratoma resection exclusion criteria: * associated anorectal malformation * associated neurological pathology

Keywords: teratoma sacrococcygeal region urinary incontinence neurogenic bladder children
affecting factors for chronic pain after mastectomy

Conditions: Mastectomy; Pain, Chronic; Pain, Acute; Breast Surgery; Breast Cancer Surgery

Summary: chronic post-mastectomy pain (cpmp) is a significant issue affecting many women after mastectomy. factors like age, treatment type, and pre-surgery pain can increase the risk of developing this condition. by evaluating these factors, cpmp can be prevented more successfully and treatment strategies can be developed. this study aims to investigate the factors contributing to cpmp and contribute to the existing literature on this important topic.

chronic post-mastectomy pain (cpmp) is a common condition and is a significant clinical problem with a prevalence reported in the literature of up to 50%. approximately 10% of patients experience severe pain, which has a significant impact on their quality of life. since mastectomy is a frequently performed procedure, this syndrome affects a large number of women. therefore, it is important to better understand the factors associated with the development of persistent pain. several theories have been proposed regarding the development of cpmp, including increased peripheral nociceptor sensitivity (primary hyperalgesia) at the site of injury, central neuronal sensitivity (central hyperalgesia) in spinal and supraspinal regions innervating the injured area, and inflammatory changes triggered by the central nervous system. recommended methods to prevent cpmp include careful dissection, reduction of inflammatory responses, and the use of minimally invasive surgical techniques to prevent peripheral and central neuronal sensitization. epidemiological studies-both retrospective and prospective-have identified some of these risk factors, such as younger age, chemotherapy, radiotherapy, and the presence of preoperative pain or severe acute postoperative pain. unfortunately, there are few studies on this topic, and the literature needs further support. the hypothesis in this study is that if investigator can identify the factors that increase chronic pain after mastectomy, investigator can take measures against these factors and reduce the development of chronic pain. therefore, this study aims to identify the factors contributing to chronic pain after mastectomy.

Eligibility criteria:
inclusion criteria: * between the ages of 18-80 * bmi 18-35 kg/m2 * asa (american society of anesthesiologists) scoring i-ii-iii * elective mastectomy surgery * elective mastectomy and axillary dissection surgery * patients who will undergo general anesthesia * patients who agree to participate in the study and sign a form exclusion criteria: * patients under 18 and over 80 years of age * patients who do not want to participate in the study * patients with chronic pain or chronic opioid use * patients with alcohol, substance or drug addiction * patients with a history of previous mastectomy * patients with limited cooperation such as dementia, psychiatric disorders * pregnant and breastfeeding patients will be excluded from the study * patients who cannot communicate in their native language will be excluded from the study
construction of a questionnaire on panic disorder and agoraphobia

Conditions: Panic Disorder; Panic Disorder With Agoraphobia; Agoraphobia; Agoraphobia With Panic Attacks; Depression

Summary: for the first time panic disorder and agoraphobia are included as separate disorders in the dsm-5. thus, agoraphobia no longer represents a subcategory of panic disorder. to diagnose both of the disorders, questionnaires are the method of choice. however, there are no measuring instruments available free of charge in german-speaking countries. in order to improve this situation, the witten panic disorder questionnaire (wpf) and the witten agoraphobia questionnaire (waf) are constructed in accordance with the dsm-5 criteria. both measuring instruments are included as a part of a ten instrument battery. waf and wpf will be delivered to a patient sample of patients with panic disorder and/or agoraphobia as well as depressed patients (discriminant validity). factor analyzes and item analyses will be conducted.


Eligibility criteria:
inclusion criteria: panic disorder / agoraphobia / depression diagnosis via diagnostic interview exclusion criteria: -
determining the benefits of improving communication in bpap/cpap users

Conditions: Positive-Pressure Respiration; Communication

Summary: the purpose of this study is to determine the effectiveness of a non-invasive communication aid for bpap/cpap masks. this study also looks to determine the potential impact of the device on patients with obstructive sleep apnea (osa) and the individuals that interact with the device.

noninvasive positive pressure ventilation (nippv) is a crucial tool used to treat respiratory distress and failure, especially when patients have acute worsening (also called exacerbations) of emphysema or chronic obstructive pulmonary disease (copd). this study will randomize patients who use noninvasive positive pressure ventilation (nippv) to a control (non-functioning) and intervention (functioning) device to determine how well speech can be understood while wearing the device. the purpose of this study is to determine the effectiveness of a non-invasive communication aid for bpap/cpap masks. this study also looks to determine the potential impact of the device on patients with obstructive sleep apnea (osa) and the individuals that interact with the device.

Eligibility criteria:
inclusion criteria: * patients must be receiving bpap/cpap therapy in the outpatient setting (e.g. clinics, sleep centers). exclusion criteria: * intubated or have a tracheostomy. * vulnerable populations (children, pregnant women, decisionally impaired adults, and prisoners). * speech disabilities, reading disabilities, dyslexia.

Keywords: emphysema chronic obstructive pulmonary disease obstructive sleep apnea