Kornimate/medical-research-clean huggingface dataset:
study evaluating inductos in diaphyseal tibia fractures

Conditions: Tibial Fractures

Summary: demonstrate a larger proportion of subjects with healed fractures among subjects treated with inductos and reamed, locked intramedullary nailing compared to subjects treated with reamed, locked intramedullary nailing alone.


Eligibility criteria:
inclusion criteria: * subjects with acute open tibial shaft fractures (gustilo type i, ii, iiia, or iiib) who require surgical management with reamed, statically locked intramedullary nail fixation and who are at low risk for amputation. * subjects should be at least 18 years of age, be skeletally mature, and be able to provide written informed consent. * initial fracture stabilization and wound debridement should occur within 1 day after injury and dfc should occur within 14 days after injury. exclusion criteria: * planned treatment for the fracture should not include further procedures to promote fracture healing. after 16 weeks have elapsed since dfc, unanticipated procedures to promote fracture healing are permitted as clinically indicated. * presence of fracture distraction \> 2 mm following definitive fracture fixation. * presence of purulent drainage from the fracture site or evidence of active osteomyelitis.

Keywords: open diaphyseal tibia fractures
the effect of reflexology on pain, anxiety and comfort level

Conditions: Myocardial Infarction; Angina Pectoris

Summary: this study was performed as a randomized controlled a study with a pre test-post test design, aimed to determine affect of reflexology masagge to the pain, anxiety and comfort level on the patients that are percutaneous coronary intervention.

a total of 74 patients, 37 in the experimental group and 37 in the placebo group, who met the criteria for inclusion in the study, constituted the sample of the study. research data were collected with "structured patient information form", "vital signs form", "state anxiety scale", "visual comparison scale", "mcgill pain scale short form" and "general comfort scale short form". appropriate statistical methods were used in the analysis of the data. reflexology massage is a well tolerated, inexpensive, applicable and safe non-pharmacological method. the fact that nurses are educated and experienced about reflexology massage is of great importance for integrating reflexology massage into clinical settings. if the results of this study are significant, it will be concluded that reflexology massage is effective in the management of pain and anxiety and increasing the comfort level in patients undergoing pci. it will be recommended that reflexology massage be used in clinics to reduce pain, anxiety and increase comfort level in individuals undergoing pci, and to include it in patient education. no study has been found in the national literature evaluating the effectiveness of reflexology massage in the management of pci-related pain, anxiety and comfort. it is thought that this study will fill an important gap in the literature. the aim of this study, carried out in this context, is to reveal the effect of reflexology massage on pain, anxiety and comfort level in patients undergoing pci.

Eligibility criteria:
inclusion criteria: * over 18 years old, * literate, diagnosed with pci-related pain, * pain score of 4 out of 10 according to visual comparison scale (vas) after pci. exclusion criteria: * presence of a pacemaker, * having a diagnosis of diabetic foot, * presence of vision, hearing, cognitive ability impairment or psychosis, * being pregnant, * presence of disc herniation, * any contagious skin disease (shingles, fungus, etc.), open lesion/wound on the lower extremities, scar tissue, fracture, dislocation, amputation, edema, hematoma, thrombophlebitis, inflammatory and degenerative joint disease, * having applied reflexology massage in the last month
effectiveness of task specific home exercise program

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to compare the effectiveness of 2 different types of home exercise programs (hep) on mobility in persons with multiple sclerosis (ms). specifically, we will be comparing the standard of care (soc) a program based on aerobic conditioning and calisthenics to a task specific program (tsp). primary question: will persons with who receive a task specific hep have greater improvement in mobility than those who receive the soc? secondary question: will a task specific hep be as well tolerated as the soc hep by persons with ms

persons with ms have been shown to benefit from exercise to address the symptoms of their disease. exercise programs are customarily given by physical therapists (pt) in either an inpatient or outpatient setting. outpatient pt is typically augmented with a home exercise program (hep) which is meant to enhance the work that is done directly with the pt. since the amount of exercise done at home is often greater than what is done with the pt, the hep is of great importance. however, the types of exercise that are the most useful for useful for persons with ms has not been established. previous research has shown that due to the unique ways in which ms can affect the nervous system, exercise programs that may be appropriate for persons without ms may not be ideal for those that have the disease

Eligibility criteria:
inclusion criteria: definitive diagnosis of multiple sclerosis * ability to walk for at least 30 seconds unassisted with or without assistive device * ability to read, comprehend and sign an informed consent * is able to attend a 2 outpatient evaluation sessions 6 weeks apart * between the ages of 18 and 75 exclusion criteria: * evidence of recent ms exacerbation * any orthopedic, cardiopulmonary, or non- ms neurologic condition that prohibits participation in a physical therapy program * be currently receiving outpatient physical therapy
evaluation of using iliac crest with and without platelet-rich fibrin in repair of congenital alveolar cleft

Conditions: Alveolar Clefts; Alveolar Bone Grafting; Alveolar Bone Loss

Summary: a randomized clinical trial aims to evaluate the clinical and radiographic outcomes of the repair of congenital alveolar clefts using iliac crest graft with and without mixing with platelet-rich fibrin

alveolar clefts occur in response to deviations from normal development in the growth, exposure, and fusion of the frontal eminence. the most common alveolar portion of the cleft is located between the central incisors and canines. the treatment of alveolar clefts is multidisciplinary and aimed at restoring normal ridge contour and functionality. surgical wound closure is insufficient to repair bony defects, additional materials are needed for these types of defects, such as bone grafts. aim: the aim of this study is to evaluate the efficiency of using iliac crest bone graft with and without platelet-rich fibrin in repair of alveolar clefts. methodology: this study will be conducted on 16 patients with alveolar clefts. the patients will be divided equally and randomly into 2 groups: group 1 : 8 patients will be treated with iliac crest bone graft only (control group).group 2: 8 patients will be treated with iliac crest bone graft with platelet-rich fibrin (study group).

Eligibility criteria:
inclusion criteria: 1. patients with congenital alveolar cleft who need secondary alveolar cleft repair. 2. patients who are medically fit for surgery under general anaesthesia exclusion criteria: 1. asa 4 or asa 5 patients 2. uncooperative patients

Keywords: alveolar clefts iliac crest graft prf
a study to evaluate the efficacy and safety of meptin® swinghaler and berotec n® metered aerosol in mild to moderate stable asthma patients

Conditions: Asthma

Summary: this is an open-label, randomized, cross-over, active-controlled study to evaluate the efficacy and safety effects using meptin® swinghaler and berotec n® metered aerosol in stable asthma patients


Eligibility criteria:
inclusion criteria: * male or females outpatients aged ≥18 years old with uncontrolled or partly controlled asthma; stability was assessed during the past 14 days the patients remained in the same severity class by 2006 gina guideline (uncontrolled, partly controlled) and had no acute exacerbations by investigator judgment; * pulmonary function test: improvement ≥12% reversibility in fev1 or fvc following administration of an inhaled β2-agonist before the study or ; positive result of brocho-provocation test; exclusion criteria: * hypersensitivity to β2-agonist or lactose; * hospitalization due to asthma during the previous 3 months; * respiratory tract infection requiring treatment with antibiotics in the previous 4 weeks; * oral or systemic corticosteroids in the previous 4 weeks; * inadequately controlled hyperthyroidism; * subjects with any clinically significant disorder of the cardiovascular, neurologic, hematologic, gastrointestinal, cerebrovascular, or immunologic system or respiratory disease other than asthma(e.g. copd), or any other disorder which may interfere wth the study evaluations or affect subject safety; * patients receive an investigational drug within 30 days prior to admission to the study; * patients with significant alcohol, drug or medication abuse as judged by the investigator; * females who are pregnant or breast-feeding; (exception: females of child-bearing age might be included, if in the opinion of the investigator, they are using adequate contraceptive precautions); * subjects who are heavy smoker (more than 10 packs year) or who are smoking within previous 6 months.
risk factors for neuroendocrine neoplasms

Conditions: Neuroendocrine Neoplasm of Lung; Neuroendocrine Neoplasm of Gastrointestinal Tract (Disorder)

Summary: recent studies show an increase in neuroendocrine neoplasms, especially for the digestive tract. previous studies suggest various risk factors that were observed for various tumor sites, e.g. a family history of cancer, tobacco and alcohol consumption as well as metabolic disorders including diabetes and obesity. a risk factor that has been little studied to date is depressive disorders, which could increase the risk of neuroendocrine neoplasms either independently or through associated risk behaviors and/or antidepressant medication. the aim of this study is to identify risk factors for neuroendocrine neoplasms based on a case-control study in order to better understand the increase of neuroendocrine neoplasms in recent decades. the study is based on a record linkage of data from the bavarian cancer registry and data from the bavarian association of statutory health insurance accredited physicians. while the data from the bavarian cancer registry enables the identification of neuroendocrine neoplasms on the basis of histopathological findings and thus is the basis for selecting cases, the claims data from the bavarian association of statutory health insurance accredited physicians provides the source population as well data on diagnoses and thus enables the investigation of risk factors.


Eligibility criteria:
inclusion criteria: * persons with a statutory health insurance (about 85% of the population) and at least one outpatient physician contact in bavaria between 2021 and 2023 * residence in bavaria exclusion criteria: * none

Keywords: neuroendocrine neoplasms colorectal cancer risk factors case-control study cancer registry
costs of complications in inguinal hernia repair

Conditions: Inguinal Hernia; Complication

Summary: laparoscopic inguinal hernia repair is becoming increasingly popular mainly because of short-term advantages compared to open hernioplasties with mesh. in the prevailing economic climate, the total costs of treatment is a subject of intense research. this study is designed to evaluate the results of open and laparoscopic inguinal hernia repairs, with a special emphasis in costs of treatment, complications and convalescence.


Eligibility criteria:
inclusion criteria: * patients treated surgically for inguinal hernia between 2002-2011 exclusion criteria: * none
effect of bariatric surgery on gut hormones production and cure of type 2 diabetes mellitus

Conditions: Surgery

Summary: type 2 diabetes mellitus (t2dm) is a relevant public health problem and obesity has been associated as the major risk factor. roux-en-y gastric bypass is an effective method to treat severe obesity, and its metabolic benefits can lead to early and complete remission of t2dm, even before a considerable weight loss. we have hypothesized that intestinal anatomic changes may change intestinal genes expression related to glycemic control. the knowledge of mechanisms mediating the glycemic control after roux-en-y gastric bypass and it site of action in bowel may eventually help to develop alternative, less invasive and safer surgery for the treatment of t2dm, as well as drug development for the newly targets identified.


Eligibility criteria:
inclusion criteria: type 2 diabetes mellitus (t2dm) diagnosis duration of t2dm \>5 years use of oral antidiabetic agents body mass index \>40 kg/m2 candidates to roux-en-y gastric bypass exclusion criteria: type 1 diabetes mellitus or non-diabetics use of insulin thyroid diseases candidate to other surgery technique body mass index \<40 kg/m2 presence of bacterium h. pylori

Keywords: type 2 diabetes mellitus y-roux gastric bypass gut hormones gene expression surgery
does statin therapy reduce sympathoexcitation in hypertension?

Conditions: Hypertension

Summary: a number of patients with hypertension have increased central sympathetic activity. statins seem to inhibit central sympathetic output. this study assesses the effect of statins on central sympathetic activity in hypertension patients.


Eligibility criteria:
inclusion criteria: * (known) hypertension * stable drug therapy for at least 2 months * age 18-70 jaar * bmi 18-35 kg/m2 * sinusrhythm exclusion criteria: * recent cardiovascular event \<6 mnd * plasma creatinin: * female: \>120 mmol/l * male: \>133 mmol/l * use of: * tricyclic antidepressants * alpha-1 -and/or alpha-2 blockers * disease of the autonomic nervous system (parkinsons disease, shy- drager syndrome, etc) * albuminuria \>300 mg/dag

Keywords: hypertension statin sympathetic
lmca treatment outcome

Conditions: Left Main Coronary Artery

Summary: left main coronary artery (lmca) is a major branch of coronary artery and supplies a large bulk of myocardium. revascularization by either surgical coronary bypass grafting (cabg) or percutaneous coronary intervention (pci) is recommended for significant unprotected lmca disease, with cabg being preferred if there is significant involvement in other coronary arteries1,2. cabg has been demonstrated to confer survival benefit over medical therapies patients with lmca in earlier clinical trials3,4,5. however, these trials were performed before the wide adoption of modern medical therapies such as antiplatelet and statin. antiplatelet agents, for example, was only used in 32% of all patients in the coronary artery surgery study3. modern day medical treatment for stable coronary artery diseases have been shown to be non-inferior to revascularization in both the courage and ischemia trials6,7. however, patients with lmca involvement were mostly excluded from both of these studies. in hong kong, the average waiting time for an elective cabg for stable patients with lmca is around 18 months, during which time the patients are treated with modern medical therapies including high-intensity statin and antiplatelet.

left main coronary artery (lmca) is a major branch of coronary artery and supplies a large bulk of myocardium. revascularization by either surgical coronary bypass grafting (cabg) or percutaneous coronary intervention (pci) is recommended for significant unprotected lmca disease, with cabg being preferred if there is significant involvement in other coronary arteries1,2. cabg has been demonstrated to confer survival benefit over medical therapies patients with lmca in earlier clinical trials3,4,5. however, these trials were performed before the wide adoption of modern medical therapies such as antiplatelet and statin. antiplatelet agents, for example, was only used in 32% of all patients in the coronary artery surgery study3. modern day medical treatment for stable coronary artery diseases have been shown to be non-inferior to revascularization in both the courage and ischemia trials6,7. however, patients with lmca involvement were mostly excluded from both of these studies. in hong kong, the average waiting time for an elective cabg for stable patients with lmca is around 18 months, during which time the patients are treated with modern medical therapies including high-intensity statin and antiplatelet.

Eligibility criteria:
inclusion criteria: * patients with significant lmca disease who were on the waitlist for cabg since 1st january 2000 to 31st december 2020. * the decision for cabg over pci as a mode of revascularization for the patients on this waitlist were collectively made by the heart team exclusion criteria: * patients with co-existing significant valvular heart disease requiring concomitant surgical intervention, and unstable patients in whom urgent surgical intervention was performed
seasonal malaria chemoprevention versus home management of malaria in children under 5 years in ghana

Conditions: Malaria; Anaemia

Summary: in areas of africa where malaria is only a problem during a short rainy season, monthly courses of antimalarial drugs can provide very effective prevention of malaria in children. this approach, called intermittent preventive treatment in children (iptc) but now known as seasonal malaria chemoprevention (smc), may also be useful in large areas of africa where malaria is transmitted for longer each year. it is uncertain if iptc would be effective, acceptable to communities or sustainable when delivered over a longer period, but this is an important public health question of key interest to policy makers, because in areas with a longer transmission season, the burden of malaria is typically higher than in highly seasonal areas. another form of prevention that would be operationally easier for african countries to put into practice would be to treat malaria patients with long-lasting antimalarials, which protect children against further malaria episodes for several weeks. because malaria disproportionately affects certain high risk children more than others, causing repeated attacks of fever and leading to severe anaemia, long-acting drugs may be a simple and effective way to target limited resources at the individuals who most need protection. this may be particularly beneficial where malaria is a seasonal problem, because repeated malaria attacks will not only be borne by a few unfortunate children, but will also occur close together in time. the investigators propose a clinical trial to evaluate these two forms of chemoprevention in kumasi, ghana, an area with an extended malaria transmission season. children under 5 years of age currently have access to diagnosis and treatment of malaria via by community based health workers. children enrolled in the study will receive either the standard community-based diagnosis and treatment, treatment with a longer-acting artemisinin combination therapy (act), or standard care plus five monthly courses of seasonal malaria chemoprevention (smc) during the peak in transmission.


Eligibility criteria:
inclusion criteria: * children aged between 3-59 months * care giver or parent willing to participate and have given informed consent * children living in the study area exclusion criteria: * children who are unable to take and retain medication * children who have a severe or chronic illness * children who have a history of serious adverse reaction to the study drugs

Keywords: home management of malaria seasonal malaria chemoprevention
effect of low level laser therapy on root resorption during orthodontic intrusion of maxillary incisors

Conditions: Root Resorption of Maxillary Incisors

Summary: the present study will be directed to evaluate the effect of low-level laser therapy on root resorption during orthodontic intrusion of upper incisors.


Eligibility criteria:
inclusion criteria: * patients with age range between 12-16 years. * overbite \> 40% indicated for maxillary intrusion. * mild to moderate crowding of upper incisors. * all permanent teeth erupted (excluding 3rd molars). * no previous orthodontic treatment. * good oral hygiene with no previous periodontal surgery exclusion criteria: * transverse and/or vertical skeletal dysplasia or craniofacial malformation. * retained primary or missing permanent teeth in the maxillary anterior area, and any kind of tooth/root shape anomaly. * patients with root resorption, impacted canines, or dental anomalies. * poor oral hygiene * present or history of periodontal diseases. * systemic diseases or regular use of medications that could interfere with orthodontic tooth movement. * history of trauma affecting the maxillary incisors. * endodontically treated upper anterior teeth.
sildenafil for treatment of choroidal ischemia

Conditions: Choroidal Ischemia; Vitelliform Macular Dystrophy; Age-related Macular Degeneration; Central Serous Retinopathy; Retinitis Pigmentosa

Summary: the hypothesis of this study is to determine if there is a benefit afforded by the use of systemic sildenafil to patients with choroidal and retinal degenerations and dystrophies, such as vitelliform degeneration, dry and reticular age-related macular degeneration (amd) as well as patients with hereditary and acquired retinal dystrophies such as retinitis pigmentosa and central serous retinopathy.

age-related macular degeneration (amd) is a sight-threatening visual disturbance that affects the macula in older ages. it is irreversible if the pigment epithelium is lost (dry amd), but wet amd can be arrested or delayed with the use of intraocular injections of one of 3 different compounds. all three drugs are injected into the eye in minute doses of usually 0.1 ml. these are usually injected at 4 to 6 week intervals and treatment may be extended for several years. different patterns of injection times are followed but usually are monthly for 12 or more months, or monthly for 3 months and then extended observation at one to two month intervals unless vision (visual acuity) declines or optical coherence tomography-angiography (oct-a) shows recurrence of fluid or increase in size or amount of drusen (deposits of lipofuscin) in the retina. vitelliform macular degeneration is a disorder that causes visual loss due to drusen in the macula, which have been shown to be identical to the deposits seen in macular degeneration. the goal of therapy in this proposal is to use sildenafil to increase choroidal blood flow to treat dry amd and slow the progression of visual loss in vitelliform and age-related dry amd as well as other macular, retinal and choroidal degenerations and dystrophies, as well as reduce or eliminate the number of injections required by slowing down transformation of dry amd to wet amd in treated patients.

Eligibility criteria:
inclusion criteria: * diagnosis of retinal and choroidal degenerations (reticular or vitelliform amd or vitelliform-type subretinal drusen) or hereditary or acquired retinal dystrophies (retinitis pigmentosa or central serous retinopathy) exclusion criteria: * diagnosis of heart disease requiring use of nitrates * inability to be examined monthly or bi-monthly

Keywords: sildenafil viagra revatio