Kornimate/medical-research-clean huggingface dataset:
safety and efficacy of switching from regimens of abc/3tc + a 3rd agent to e/c/f/taf fixed-dose combination (fdc) in virologically-suppressed hiv 1 infected adults

Conditions: HIV-1 Infection

Summary: the primary objective of this study is to evaluate the efficacy of switching to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (e/c/f/taf) fixed-dose combination (fdc) relative to continuing on a baseline regimen consisting of abacavir/lamivudine (abc/3tc) plus a 3rd antiretroviral agent in hiv-1 infected participants.


Eligibility criteria:
key inclusion criteria: hiv-infected adult participants who meet the following criteria will be given the option to participate in the study: * currently receiving abc/3tc plus a third antiretroviral (arv) agent for ≥ 6 consecutive months preceding the screening visit. for subjects with 3 or more art regimens, a regimen history must be provided to the sponsor for approval. allowed third antiretroviral agents include lpv/r, atv+rtv, atv+cobi (or atv/cobi fdc), drv+rtv, drv + cobi (or drv/cobi fdc) fpv + rtv, sqv + rtv, atv (no booster), efv, rpv, nvp, etr, ral or dtg * documented plasma hiv-1 rna levels \ 50 and \< 400 copies/ml) is acceptable, only if hiv-1 rna is \< 50 copies/ml immediately before and after the "blip". * plasma hiv-1 rna \< 50 copies/ml at screening visit * individuals will have no evidence of previous virologic failure on a pi+rtv or integrase strand transfer inhibitor-based regimen (with or without resistance to either class of arv). * all documented historical plasma genotype(s) must not show resistance to tenofovir disoproxil fumarate (tdf) or emtricitabine (ftc), including, but not limited to the presence of reverse transcriptase resistance mutants k65r, k70e, m184v/i, or thymidine analog associated mutations (tams) (tams are: m41l, d67n, k70r, l210w, t215y/f, k219q/e/n/r). if a historical genotype is not available or subject has 3 or more art regimens, subject will have proviral genotype analysis prior to day 1 to confirm absence of archived resistance to tdf or ftc. * adequate renal function defined as having an estimated glomerular filtration rate of ≥ 30 ml/min as calculated by cockcroft-gault (egfr-cg) note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: hiv 1 infection hiv virologically-suppressed antiretroviral agents
positron emission tomography (pet) with 3,4-dihydroxy-6-18f-fluoro-l-enylalanine (18f-fdopa) study

Conditions: Cancer (High-grace Glioma)

Summary: the 18f-fdopa pet tracer is an amino acid analogue that can be used to visualize high-grade glioma not clearly identified on diagnostic mri. use of 18f-fdopa pet will permit neurosurgeons to achieve a complete resection more frequently.


Eligibility criteria:
inclusion criteria: * contrast-enhancing mass on diagnostic brain ct or mri strongly suggesting a diagnosis of who grade iii or iv glioma * karnofsky performance status (kps) ≥ 70 * age ≥18 years * subject is able to understand and consent to study * glomerular filtration rate (gfr) ≥ 45 ml/minute exclusion criteria: * indication for urgent craniotomy to relieve mass effect * only stereotactic biopsy indicated because tumour is located in eloquent brain. * the enhancement on the t1 mri sequence involves or abuts the basal ganglia * previous intracranial malignancy or any invasive malignancy unless free of disease \> 5 years * prior cranial irradiation * contra-indications to systemic radiation exposure: pregnancy or breast feeding * subject exceeds the weight limit of the pet scanner bed (204.5 kg) * subjects taking medication such as levodopa for the treatment of parkinson's disease * allergies or other contraindication to ct contrast or mri contrast

Keywords: neurosurgery neuronavigation positron emission tomography fdopa
postural stability, pelvic floor dysfunction, respiratory muscle strength in post-partum women with diastasis recti

Conditions: Diastasis Recti; Post-partum; Postural Stability

Summary: the aim of this study is to determine the effect of inter-rectus distance on postural stability, pelvic floor dysfunction and respiratory muscle strength in women with diastasis recti abdominis.

diastasis of recti abdominis muscles (dram) is defined as a separation of the two rectus abdominis muscles along the linea alba. increased volume in the abdominal cavity, hormonal changes during pregnancy, neurodevelopmental differences, or abdominal wall laxity may caused. it is very common during pregnancy and may continue for eight weeks in postnatal period. the loss of abdominal wall stability and weakened pelvic floor muscles may occur with dram. the abdominal wall is one of the key point for body posture, trunk and pelvic stability. however, in our best knowledge, there is no study in the literature that evaluates women with and without dra in terms of components related to postural control systems.

Eligibility criteria:
inclusion criteria: * post- partum women (min 8 weeks - max 5 years) exclusion criteria: * having a neurological, orthopedical or any other condition which affect postural stability.
pronase granules in gastric cleaning

Conditions: Gastric Disease; Capsule Endoscopy

Summary: magnetically controlled capsule endoscopy (mce) is now widely used all over the world. however, the standard gastric preparation method by dimethicone we used clinically still has mucus at the bottom of the stomach. in this study, we aimed to determine whether pronase granules is helpful to improve the cleanliness of gastric mucosa in mce.

as a non-invasive and well-tolerated gastrointestinal examination method, magnetically controlled capsule endoscopy (mce) is being increasingly used in different populations in recent years. gastric preparation is extremely important for the completion rate (cr), image quality, and diagnostic efficiency because of the plica of gastric mucosa and the autonomous movement of the capsule in the gastrointestinal tract. after a series of explorations including air-producing powder, defoamer, protease preparation, patients are asked to drink about 800 ml-1000 ml water in a short time for standard gastric filling. however, the existing problems of gastric preparation such as abdominal distension, insufficient gastric filling, and long gastric retention time deserve attention. different from the results of zhu et al. (dld, 2017), the current clinical experience shows that the addition of pronase granules in gastric preparation can often reduce the mucus in the stomach. but the standardized use of pronase granules remains to be further explored.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years old. 2. those who underwent upper gastrointestinal and small intestinal mucosal examination under magnetically controlled capsule endoscopy at shanghai changhai hospital and chinese people's liberation army general hospital after january 2020. 3. able to provide informed consent. exclusion criteria: 1. dysphagia or symptoms of gastric outlet obstruction, suspected or known intestinal stenosis, overt gastrointestinal bleeding, history of upper gastrointestinal surgery or abdominal surgery altering gastrointestinal anatomy, or post-abdominal radiation; 2. congestive heart failure, renal insufficiency, use of anticoagulant medication, 3. implanted metallic devices such as pacemakers, defibrillators, artificial heart valves or joint prostheses (although the low magnetic field used technically should not interfere with such devices); 4. pregnancy; 5. currently participating in another clinical study. 6. patients who fail to follow the prescribed procedures for magnetically controlled capsule endoscopy; 7. patients who only undergo gastric examination under magnetically controlled capsule endoscopy; 8. patients who only undergo small bowel examination under magnetic control capsule endoscopy; 9. the patient's basic information in the database is incomplete# 10. patient fail to be followed up.

Keywords: capsule endoscopy pronase granules gastric preparation visualization of gastric mucosa randomized controlled study
using electronic medical record data to improve hiv primary care

Conditions: Quality of Health Care; HIV/AIDS; Electronic Health Records

Summary: this cluster randomized control trial examines whether an audit and feedback study improves care of patients living with hiv/aids in a family health team setting.

this cluster randomized control trial will use electronic medical record (emr) data from the st. michael's hospital academic family health team to examine whether the quality of hiv care provided to patients can be improved through an audit and feedback (a\&f) intervention. our objective is to examine whether a\&f targeting family physicians caring for people living with hiv/aids (phla) using emr data can improve laboratory monitoring, engagement in primary care and the uptake of preventive interventions.

Eligibility criteria:
inclusion criteria: * family physicians at the st. michael's hospital academic family health team who have at least 20 plha. exclusion criteria: * none
manual diaphragm release on stepping reaction time in chronic obstructive pulmonary disease

Conditions: Respiratory Disease

Summary: finding the effect of diaphragm release exercises on stepping reaction time and balance in patients with chronic obstructive pulmonary disease patients.

sixty patients with chronic obstructive pulmonary disease (copd) will be randomly assigned to the experimental (ex) group and the control group (con). the participants' age will be 55 years and above with history of copd. the ex group will attend 4 sessions/week of manual diaphragm release technique combined with deep breathing (10:15-min) for 8 weeks, the con will attend 4 sessions/week of deep breathing (10:15-min) for 8 weeks. the stepping reaction time will be assessed by the choice stepping reaction time (csrt). the balance will be determined using a time up and go test (tug) an d berg balance scale (bbs). all the outcomes will be examined at baseline, and 8 weeks of the intervention.

Eligibility criteria:
inclusion criteria: * all participants with a history of copd * adults ranging from 55- 70 years old of both genders. * medically stable exclusion criteria: * obesity (bmi ≥ 30 kg/m2) * history of pneumonia * diaphragmatic hernia, clinical evidence of phrenic nerve injury, recent abdominal or thoracic surgery, or history of traumatic lesion possibly affecting diaphragm. * history of myocardial infarction and/or cardiothoracic surgery * orthopedics, or neurological that may interfere the intervention. * visual impairments, vestibular disorders, and postural hypotension. * dementia that interferes with the ability to follow instructions.
use of prokinetics in early enteral feeding in preterm infants

Conditions: Feeding Disorder; Nutrition Disorder; Infant,Premature

Summary: objective of this study are: 1) to determine if medication help extreme preterm infants to tolerate feeding better by reaching full feeding earlier.2) out of two medication; which one is better for efficacy 1) erythromycin 2) metoclopramide. infants who meet inclusion criteria would be entered to study after parental consent. infant would be blinded to care givers. infants will be randomized to receive one of three medication for 7-14 days. if infants fail on one medication they will be allowed to crossover to other medication. infant would be allowed to treat like other infants. blindness can be broken if deem necessary by attending neonatologist.

inclusion critera: 1. weight below 1250 grams 2. age less than 14 days 3. feeding intolerance; if feeding residual more than 30% on q3 hr feeding; 5 times out of 8 times, feeding residual more than 20% on q4 hr feeding 4 feeding out of 6 feeding or failure to advance feeding of more than 20ml/kg in 72 hrs. exclusion criteria 1. gi malformation or perforation 2. genetic disorder 3. parents can't read english. after consent, if infants meet inclusion criteria, he would be allowed to receive one of the following three medication. 1) erythromycin at 1mg/kg/dose q8 hr 2) metoclopramide 0.1mg/kg/dose q8 hrs and placebo. if infant fails to get better, he would be crossover to one of the remaining two.

Eligibility criteria:
inclusion criteria: 1. weight below 1250 grams 2. age less than 14 days 3. feeding intolerance; if feeding residual more than 30% on q3 hr feeding; 5 times out of 8 times, feeding residual more than 20% on q4 hr feeding 4 feeding out of 6 feeding or failure to advance feeding of more than 20ml/kg in 72 hrs. exclusion criteria 1. gi malformation or perforation 2. genetic disorder 3. parents can't read english. after consent, if infants meet inclusion criteria, he would be allowed to receive one of the following three medication. 1) erythromycin at 1mg/kg/dose q8 hr 2) metoclopramide 0.1mg/kg/dose q8 hrs and placebo. if infant fails to get better, he would be crossover to one of the remaining two.
effect of fentanyl on the rate of anesthesia

Conditions: Painful Irreversible Pulpitis

Summary: achievement of a deep and long-durated anesthesia is vital before most endodontic procedures; therefore, the investigators conducted this study to compare the local infiltration effect of epinephrine-containing lidocaine with/ without fentanyl on depth and duration of anesthesia in maxillary molars with painful irreversible pulpitis.

this study was planned with a randomized double-blind, parallel design clinical trial on 64 healthy patients after taking into account some inclusion and exclusion criteria. the control group were received the mixture of normal saline and 2% lidocaine with 1:200,000 epinephrine and the experimental group were received the mixture of fentanyl and 2% lidocaine with 1:200,000 epinephrine. the depth and duration of pulpal anesthesia were evaluated with an electric pulp testing in 5-minute intervals during a period of 60 minutes and the pain intensity recorded in five times, before injection, after injection, during access cavity preparation, pulpotomy and pulpectomy using visual analog scale(vas). all data were analyzed and compared using chi-squared and mann-whitney tests.

Eligibility criteria:
inclusion criteria: * patients were aged between 18 and 65 years with no systemic diseases categorized in the class i asa; * individuals requiring urgent root canal treatment of maxillary first or second molars; * hot painful teeth with irreversible pulpitis (moderate to severe spontaneous pain), with a positive response to thermal vitality tests (a long painful response to a cold test) and no clinical or radiographic signs or symptoms of acute or chronic apical periodontitis; and * no history of taking analgesics in the previous 12 h. exclusion criteria: * systemic conditions; * allergic reactions to opioids, benzodiazepines, barbiturates; * pregnancy and lactation; contraindication of the use of epinephrine (such as unstable angina); * nonvital pulp after access cavity preparation

Keywords: irreversible pulpitis infiltration injection fentanyl lidocaine
histopathological diagnosis of adenomyosis

Conditions: Adenomyosis

Summary: the purpose of this study is to develop and evaluate a hysteroscopic endo-myometrial biopsy for diagnosing adenomyosis.


Eligibility criteria:
inclusion criteria: * females complaining of pelvic congestion: dysmenorrhea, dyspareunia, chronic pelvic pain, menorrhagia, metrorrhagia exclusion criteria: * refusal of the patient to get enrolled in the study

Keywords: adenomyosis
misa to nrds：a multicenter study in china

Conditions: Bronchopulmonary Dysplasia; Patent Ductus Arteriosus; Intraventricular Hemorrhage; Necrotizing Enterocolitis; Periventricular Leukomalacia

Summary: background treatment of neonatal respiratory distress syndrome with exogenous surfactant and mechanical ventilation made millions of preterm infants survived in neonatal intensive care unit (nicu). endotracheal intubation surfactant administration is related to invasive intubation and short periods of positive pressure ventilation and implies the risk of lung injury. continuous positive airway pressure (cpap) or nippv (non-invasive positive pressure ventilation) with surfactant but without intubation may work synergistically. this randomized trial investigated a minimal invasive surfactant administration (misa). to test the hypothesis that misa increases survival without bronchopulmonary dysplasia (bpd) at 36 weeks' gestational age in very low birth weight infants. design, setting, and participants the minimal invasive surfactant administration (misa) was a multicenter, randomized, clinical, parallel-group study conducted between july 1st, 2017, and november 30, 2018, in 8 level iii neonatal intensive care units in beijing, tianjin, and hebei province, china. the final follow-up date was march 30, 2019. participants enrolled spontaneously breathing preterm infants born between 26.1 and 31.9 weeks' gestational age with signs of respiratory distress syndrome. in an intention-to-treat design, infants were randomly assigned to receive surfactant (calf pulmonary surfactant, double-crane pharmaceutical co., china) either via a 5fr nasogastric tube during cpap/nippv-assisted spontaneous breathing (minimal invasive surfactant administration group, misa group) or after conventional endotracheal intubation during mechanical ventilation (endotracheal intubation surfactant administration group, eisa group). intervention misa via a 5fr nasogastric tube with an ophthalmic surgery straight forceps.


Eligibility criteria:
inclusion criteria: 1. preterm infants born before 32 weeks gestational age 2. spontaneously breathing receiving continuous positive airway pressure (cpap) or nippv (non-invasive positive pressure ventilation) without intubation 3. clinical diagnosis of respiratory distress syndrome. exclusion criteria: 1. with obvious malformations 2. with asphyxia requiring intubation during resuscitation 3. need endotracheal intubation or mechanical ventilation before surfactant administration.
prevalence and serotype distribution of streptococcus pneumoniae in healthy vietnamese children from 6 months to 5 years old

Conditions: Streptococcus Pneumonia

Summary: this observational study is designed as a cross-sectional survey of children from 6 months and 5 years old who visit the vietnam vaccination center (vnvc) system in hanoi, danang and ho chi minh city for vaccination services. after getting the informed consent form from a parent/guardian for their child(s) to participate in the study, nasopharyngeal swab sample will be taken. his/her guardian will be interviewed face-to-face with information related to epidemiological characteristics, nutritional status, child's birth history, hospitalization history, vaccination history, recent antibiotic usage, breastfeeding time, and environmental and lifestyle factors. the goal is to document the burden and risk factors of pneumococcal infections in the community of healthy vietnamese children. the main questions it aims to answer are: * what is the prevalence of pneumococcus in healthy children? * what is the distribution of pneumococcus serotypes in the community of healthy vietnamese children? * what are risk factors of pneumococcus infection in the community of healthy vietnamese children?


Eligibility criteria:
inclusion criteria: * children between 6 months and 5 years exclusion criteria: * children with chronic diseases (including immunologic diseases, neoplastic disorders, renal, cardiac, hepatic, or hematologic diseases, broncho dysplasia, down syndrome, chronic otitis media with effusion) * children with acute/chronic upper or lower respiratory tract infection * children have used antibiotics within 1 week prior to entering the study
getne registration of thyroid cancer

Conditions: Thyroid Cancer

Summary: an epidemiological, observational, multicenter, cross-sectional, retrospective study on patients ≥ 18 years visited in the oncology services of the participating centers with diagnosis of primary thyroid cancer.


Eligibility criteria:
inclusion criteria: * patients older than 18 years with diagnosis of differentiated, medullary or anaplastic thyroid cancer confirmed by histopathology. * patients who agree to participate and are able to understand the information sheet and sign the informed consent exclusion criteria: * patients under 18 years of age. * patients with other types of thyroid cancer or whose histopathological diagnosis has not been confirmed. * patients who do not have the relevant basic information to be included in the study, according to the criteria of the principal investigator.
nerve entrapment in diabetic patients

Conditions: Carpal Tunnel Syndrome; Entrapment Neuropathies; Nerve Compression Syndromes; Diabetes Complications

Summary: the aim of this study is in a prospective, consecutive series of diabetic patients with carpal tunnel syndrome, who are then age and gender matched with non-diabetic patients having idiopathic carpal tunnel syndrome to compare the clinical results after carpal tunnel release.


Eligibility criteria:
inclusion criteria: * diagnosis was based on clinical history and symptoms of carpal tunnel syndrome * confirmed by nerve conduction studies. exclusion criteria: * other focal nerve entrapments * cervical radiculopathy * inflammatory joint disease * renal failure * thyroid disorders * previous wrist fracture * long-term exposure to vibrating tools.

Keywords: carpal tunnel syndrome diabetes apb strength sensory function pillar pain cold intolerance patient satisfaction
interval aerobic training and continious training

Conditions: Coronary Artery Disease; Exercise Addiction

Summary: this research is comparing the effects of interval and continuous training which are the two types of aerobic training on persons' life quality and exercise capacity on coronary artery disease patients.

the participants are diagnosed coronary artery disease aged between 40- 80 and have no mental and physical disability to take part in research. the participants' demographic infos and clinical story were recorded. to evaluate exercise capacity we used the symptom-limited exercise test (ett) and six minute walking test (6dyt). we evaluate the life quality by using short form-36 (sf-36). all those evaluation tests are done before and after training. participants are randomly divided into two groups, the first group took part in interval aerobic training (aae) while the other group was joining in continuous training (sae) three times a week during 6 weeks. in both groups, significant changes were found in ett, test time and 6 dyt scores after the rehabilitation program (p\<0,05). but only aae group have important statistical values comparing to sae group on test time and 6dyt scores. after training sae group showed significant statistical change in every sf-36 parameter, while aae group showing significant values except energy/fatigue. aae group have statistically significant changes comparing to sae group on that parameters; physical function, role limitations due to physical function, role limitations due to emotional function and general health (p\<0,05). consequently aae is much more tolerable comparing to sae and aae is considered more effective in increasing some parameters. on the other hand, we observed that both training types can be used in cardiac rehabilitation safely.

Eligibility criteria:
inclusion criteria: * diagnosed coronary artery disease * aged between 40-80 * over %55 ejection fraction exclusion criteria: * mental and physical disability * unstable angina pectoris * thrombophlebitis

Keywords: continious training interval training