Kornimate/medical-research-clean huggingface dataset:
physiotherapy treatment for gynecological cancer survivors with urinary incontinence

Conditions: Gynecologic Cancer; Urinary Incontinence

Summary: the aims of this pilot study are to examine the feasibility and to explore the effects of a physiotherapy treatment compared to standard usual care in gynecological cancer survivors with urinary incontinence in preparation of a large randomized controlled study.

epidemiological studies demonstrated a growing number of gynecological cancer survivors, and this population is at great risk of developing pelvic floor dysfunction after cancer and its treatment. representing the most prevalent pelvic floor dysfunction, urinary incontinence affects up to 70% of gynecological cancer survivors. international practice guidelines, in line with available meta-analysis, recommend physiotherapy as a first-line treatment to reduce urinary incontinence. however, there is limited evidence on its effectiveness in gynecological cancer survivors. considering the current knowledge and the negative impacts of urinary incontinence, there is an urgent need to examine whether this population can benefit from this intervention in a pilot study, to conduct eventually a larger randomized controlled trial. the objectives of the present study are to examine the feasibility and to explore the effects of a physiotherapy treatment compared to standard usual care in gynecological cancer survivors with urinary incontinence. a total of 44 participants will be randomized to receive either physiotherapy or standard usual care (wait-list for physiotherapy). baseline and post-treatment evaluations will be realized by a physiotherapist.

Eligibility criteria:
inclusion criteria: * history of gynecological cancer (endometrial, cervical, vaginal or other parts of the uterus) * scheduled oncological treatments completed * stress or mixed urinary incontinence with a frequency of at least three urinary leakage per exclusion criteria: * pelvic floor rehabilitation in the last year * other conditions interfering with assessment

Keywords: pilot study gynecological cancer survivors urinary incontinence physiotherapy
niclosamide in covid-19

Conditions: Covid19

Summary: this is a two-part, phase 2, multicentre, randomized, double blind, 2-arm placebo-controlled study in adults with moderate covid-19 with gastrointestinal signs and symptoms


Eligibility criteria:
inclusion criteria: * part 1 only: patients hospitalized with a primary diagnosis of covid-19 with or without pneumonia, who are expected to remain in hospital at least seven days after the randomization and who accept continuing to be assessed for the study procedures (home or outpatient unit) up to 6 weeks in case of discharge. part 2 only: patients with a primary diagnosis of covid-19 with or without pneumonia who are not planned to be hospitalized. * patients who prior to developing covid-19 usually have normal bowel habits defined as at least solid-formed 3 stools per week and no more than 3 solid-formed stools per day. * sars-cov-2 rna presence in rectal swab (or stool test) ≤2 days before randomization by local or central lab. * diarrhea defined as at least 3 watery stools in the last 24 hours prior to enrolment exclusion criteria: * at the time of randomization patients requiring icu admission or patients with severe respiratory insufficiency requiring mechanical ventilation or with rapid worsening of respiratory function leading to expectation for mechanical ventilation or icu admission. * evidence of rapid clinical deterioration or existence of any life-threatening co-morbidity or any other medical condition which, in the opinion of the investigator, makes the patient unsuitable for inclusion.
outcome of gatt combined with goniosynechiolysis in glaucoma patients with secondary synechial angle closure.

Conditions: Glaucoma, Angle-Closure

Summary: to evaluate the intraocular pressure reduction effect of combined gonioscopy-assisted transluminal trabeculotomy (gatt) with goniosynechialysis in eyes with secondary synechial angle closure glaucoma.

glaucoma is a group of diseases that present with cupping of the optic nerve head and visual-field defects. it is the most common cause of irreversible blindness all over the world.angle-closure glaucoma is a type of glaucoma characterized by narrowing or closure of the anterior chamber angle. two major types of angle closure glaucoma are defined by the mechanism of angle closure: in appositional contact, the iris is pushed by a pressure difference between the posterior and anterior chambers due to relative pupillary block, while in synechial contact, the peripheral iris adheres to the trabecular meshwork by peripheral anterior synechiae (pas). pas can develop in various ocular conditions, including: ocular inflammation, a post-traumatic condition, after cataract surgery, or with an iris bombe in a pupillary block glaucoma. grover et al. described a technique for ab-interno circumferential trabeculotomy termed gonioscopy-assisted transluminal trabeculotomy (gatt). the procedure aims to create a 360° trabeculotomy from an ab-interno approach. gatt procedure is a migs technique in which trabecular meshwork is circumferentially bypassed by incising it using a suture or microcatheter.in this technique, aqueous humor passes through the collector channels and episcleral veins through the cleaved open diseased trabecular meshwork. elsayed et al previously demonstrated that combining phacoemulsification with gatt in pacg yielded more favorable outcomes in terms of iop, glaucoma medications and surgical success compared to phacoemulsification alone.however, to date, no studies have looked at the outcomes of combining goniosynechialysis with gatt in secondary angle closure glaucoma. in fact, most studies looking at the outcomes of gatt in different types of glaucoma excluded eyes with synechial angle closure. goniosynechialysis (gsl) is the process of physically separating pas, which can develop in the trabecular meshwork due to various conditions including primary and secondary cases of angle closure. so, for those cases of synechial angle closure glaucoma combining gatt and gsl might aid in the iop lowering effect required.

Eligibility criteria:
inclusion criteria: * patients with secondary synechial angle closure glaucoma * involving more than 180 degrees of the iridocorneal angle * requiring surgery for uncontrolled iop despite maximum tolerated therapy. exclusion criteria: * eyes with pacg. * eyes with neovascular glaucoma. (some apparently stable nvg cases would have remnants of neo-vessels in the angle that are hidden behind the synechiae). * eyes with retinal pathology. * eyes requiring combined phacoemulsification and gatt. * eyes with corneal pathology that can preclude surgery and imaging.

Keywords: secodary angle closure gatt intra ocular pressure
block and erector comparative study between costotransverse spinae plane block in patients undergoing thoracotomy

Conditions: Pain Mangement of Thoracotomy

Summary: a thoracotomy requires a very painful incision, involving multiple muscle layers, rib resection and continuous motion as the patient breathes. treatment of acute post thoracotomy pain is particularly important not only to keep the patient comfortable but also to minimize pulmonary complications though epidural analgesia was once considered as the gold standard for post-thoracotomy pain management, it is not recommended for pain control after thoracotomy surgery because it is associated with high potential risks of dural puncture, nerve lesions, epidural hematoma and hypotension(4). thoracic paravertebral block (tpvb) and intercostal nerve block are well described and recognized techniques for postoperative analgesia following thoracic surgeries, such as thoracotomy and mastectomy


Eligibility criteria:
inclusion criteria: * • age from 18 to 75 years old. * both sexes. * american society of anesthesiologists (asa) physical status i-ii-iii. * patient undergoing unilateral thoracotomy surgery. exclusion criteria: * • bmi more than 30 kg/m2. * patients who are taking analgesics for chronic illness or have a history of substance abuse. * patients who are unable to describe their postoperative pain (e.g., language barrier or neuropsychiatric disorder). * patients with a history of coagulopathy. * severe heart diseases. * hepatic or renal insufficiency. * infection at the site of infiltration
a study of 0.15% brimonidine tartrate in patients with primary open angle glaucoma and ocular hypertension

Conditions: Glaucoma, Open-Angle; Ocular Hypertension

Summary: this study will evaluate 0.15% brimonidine tartrate in patients with primary open angle glaucoma and ocular hypertension.


Eligibility criteria:
inclusion criteria: * diagnosis of open-angle glaucoma or ocular hypertension exclusion criteria: * used alphagan® in previous 3 months
the effect of atorvastatin on endothelial cell dysfunction in chronic kidney disease

Conditions: Chronic Kidney Disease; High Cholesterol

Summary: the purpose of this study is to see if patients with chronic kidney disease have endothelial cells that don't function properly, which is thought to be a marker for cardiovascular risk. endothelial cells line the heart and blood vessels. the investigators will treat your high cholesterol with a cholesterol-lowering drug (atorvastatin, or lipitor). they will determine if this cholesterol lowering drug improves subjects' cholesterol as well as the function of endothelial cells.


Eligibility criteria:
inclusion criteria: * stage 3, 4 and 5 chronic kidney disease (not on dialysis) * hyperlipidemia requiring cholesterol lowering therapy * aged 18 to 80 years old * ability to provide informed consent exclusion criteria: * patients requiring multiple cholesterol reducing agents * patients with neovascularization present, such as neoplasm, active wounds, or significant retinopathy * patients with contraindications or allergy to statins

Keywords: chronic kidney disease high cholesterol
is long-term proton pump inhibitor use a cause of leaky gut syndrome

Conditions: Proton Pump Inhibitor Adverse Reaction

Summary: our study aims to investigate the effect of bacterial overgrowth induced by long-term ppi use on zonulin levels.

the study included a total of 75 participants, with 45 individuals classified as long-term ppi users and 30 as non-ppi users. the ppi user group was defined as those who had been consistently using ppis (specifically omeprazole, lansoprazole, pantoprazole, esomeprazole, or rabeprazole) on a daily basis for a minimum of 6 months or at least twice a week for a minimum of 2 years. the control group comprised individuals who had never used ppis. venous blood samples were taken from all participants to measure serum zonulin levels.

Eligibility criteria:
inclusion criteria: the patient group was patients taking long-term ppis (omeprazole, lansoprazole, pantoprazole, esomeprazole and rabeprazole) every day for at least 6 months or at least twice a week for at least 2 years. a control group was formed from individuals who had never used ppi. exclusion criteria: those with inflammatory bowel disease, celiac disease, type 1 diabetes, active gastroenteritis, acute kidney failure, chronic kidney failure, and those who had used antibiotics for any reason in the last 3 months, as well as those receiving probiotic drug support, were not included in the study -
treatment for the mental health impact of killing in war

Conditions: Posttraumatic Stress Disorder (PTSD)

Summary: the goal of this project is to test the feasibility, acceptability, and efficacy of a treatment module addressing the mental health and functional impact of killing in the war zone. the investigators will enroll between 12-20 veterans who have killed in war and have been diagnosed with post-traumatic stress disorder (ptsd) for a pilot study assessing the efficacy of the six-session treatment. veterans will be randomized either to the treatment or to the waitlist control group.


Eligibility criteria:
inclusion criteria: * diagnosis of ptsd * veteran will need to endorse having taken another life in a war zone context * have received some prior evidence-based treatment for ptsd exclusion criteria: * meet current or lifetime criteria for a psychotic disorder * participants in current ptsd treatment will not be excluded;however,if receiving medications they will need to be stabilized on current medications for at least one month. * if receiving prolonged exposure therapy or cognitive behavioral therapy, individuals will need to wait two weeks after they have completed the treatment to enroll in the study.

Keywords: ptsd veterans killing military
constraint-induced movement therapy for perinatal brachial plexus injury

Conditions: Neonatal Brachial Plexus Palsy

Summary: this study evaluates the addition of constraint-induced movement therapy (cimt) to usual care occupational therapy in children with perinatal brachial plexus injury. participants are randomized to receive either the intervention (cimt) or control first, then cross over to receive the other one.

children with perinatal brachial plexus injury routinely receive occupational therapy intervention to improve strength and function in their weak or paralyzed arm. constraint-induced movement therapy (cimt) is known to increase upper extremity function in children with weakness or disuse as a result of cerebral palsy. however, it is unknown if this therapy is effective for treating arm weakness or disuse as a result of perinatal brachial plexus injury. the addition of cimt to usual and standard occupational therapy care is evaluated in this trial.

Eligibility criteria:
inclusion criteria: * participant has perinatal brachial plexus injury * participant walking at time of study inception * ability to cooperate with interventions and assessment * participant currently receiving occupational therapy 1+ hour per week and planning to continue for duration of study exclusion criteria: * co-morbid diagnosis not related to perinatal brachial plexus injury * flaccidity of the involved upper extremity or no observable hand function * planned surgery or drug intervention during the study period * allergy or intolerance to constraint intervention materials
randomized control trial of the use of botox to treat chronic scrotal pain

Conditions: Scrotal Pain

Summary: there are no previous reports on the use of onabotulinumtoxina (botox) to treat men with scrotal pain that we found published. we proposed a pilot study using botox to block the nerves on a small group of men with chronic scrotal pain (csp) who have failed the standard medical therapy. the men must have had temporary relief from a testicular cord block using local anaesthetic drug. the encourage results of the pilot study has given us the background information to proceed with a formal randomised control trial of botox vs placebo. we hypothesized that botox injections to block the testicular nerve will be effective in providing long term pain relief for men with scrotal pain.


Eligibility criteria:
inclusion criteria: * age 18-65 * have nociceptive scrotal pain, * have no identifiable, reversible causes for the scrotal pain * have failed standard medical therapy * have responded temporarily to cord blocks exclusion criteria: * are interested in trying to conceive with their partners in the next 6 months, * have any local infection near the site of the injections, * have had an allergic reaction to botox in the past, * are unable to provide informed consent * have a history of motor neuron disease or neurogenic bladder * who have hemostatic disorder or who are taking aspirin, coumadin (warfarin), xarelto (rivaroxaban) or other blood thinners

Keywords: scrotal pain botox
effects of kinesio taping on performance

Conditions: Obesity

Summary: this study investigated the immediate effects of kinesio taping on muscular power, strength, endurance, and lower limb fatigue when taping is applied to rectus femoris and around the patella of obese adults based on kinesio taping techniques.

this is a randomized, double-blind, crossover, and clinical trial. ethical approval was obtained from the university's institutional review board (#2015-51). participants were recruited by flyers posted on the university campus. informed consent was completed by all participants prior to the study procedures. the subjects were obese college students. a total of 13 subjects, four males and nine females (mean age of 24.38 ± 3.01 years, mean percent body fat of 39.10 ± 6.91 % \[male: 41.93 ± 7.47 %, female: 38.16 ± 6.91 %\]), were enrolled this study. all subjects underwent three different trials which include no taping (nt), placebo taping (pt), and kinesio taping (kt). all individuals were assessed for peak and mean power, muscular strength, endurance, and muscle fatigue after each condition.

Eligibility criteria:
inclusion criteria: * percent body fat of 25 % in males, 30 % in females or more exclusion criteria: * lower limb surgery within previous 6 months * presence of any other lower limb joint diseases such as degenerative arthritis, rheumatoid arthritis.

Keywords: kinesio taping obese adults muscular function fatigue
conservative versus operative management of acute uncomplicated appendicitis

Conditions: Appendicitis

Summary: this study aims to compare antibiotic treatment versus surgery for patients with uncomplicated appendicitis.

the study will include patients aged 16 and over, with a first admission with right iliac fossa pain and a raised white cell count or c-reactive protein. patients will be randomised electronically in a 1:1 ratio either to undergo emergency appendectomy or to receive intravenous antibiotics as an inpatient, until clinical and biochemical improvement is observed, followed by outpatient oral antibiotics. those who have surgery will have 3 post-operative doses of intravenous antibiotics, unless perforation was identified at the time of surgery, in which case, microbiology will be contacted to advise regarding antibiotic choice and duration. follow-up by telephone interview will be at 1 week, 1, 3 and 12-month intervals.

Eligibility criteria:
inclusion criteria: * right iliac fossa pain * 1st episode in the past 1 year * raised wcc or crp * fluent in english exclusion criteria: * history of inflammatory bowel disease or appendectomy * b-hcg positive * significant co-morbidities * complicated appendicitis as proven by ultrasound, ct or mri * anaphylaxis to penicillin
randomized double blind controlled trial comparing a blind sciatic nerve block in the popliteal fossa to intravenous morphine for traumatic severe acute pain in the prehospital setting

Conditions: Injuries; Pain; Emergencies

Summary: the purpose of the study is to determine the efficacity of a simple blind technic of loco regional anaesthesia of the sciatic nerve compared to the gold standard in emergency medecine : the intravenous morphine for treated the severe pain of leg, ankle or foot trauma in the prehospital setting and mountain rescue.

severe pain due to leg, ankle or foot trauma do not beneficiated of a simple loco regional anaesthesia technic. loco regional anesthesia is superior to intravenous morphine for treating severe pain and specially during transportation and mobilization of the patient. the purpose of the study is to assessed a new technic of blind sciatic nerve block in the popliteal fossa in the pre hospital setting compared to the intravenous morphine. the blind technic is a modified technic of the classic sciatic nerve block with nerve stimulation.

Eligibility criteria:
inclusion criteria: * severe pain (vas \> or = 60mm); injuries of the leg, ankle or foot exclusion criteria: * hypersensitivity to student agents * local infection * nerve or vascular pathology in the affected limb, coagulation pathology, * chronic use of opoids, use of opoids within 6 hours * drug addiction * pregnancy * systolic blood pressure less than 90 mmhg * respiratory rate less than 16 per minute * glasgow coma scale \< 14.

Keywords: injuries pain block, nerve morphine prehospital emergency care
virtual exercises in patients with parkinson's disease.

Conditions: Parkinson Disease

Summary: introduction: although the motor changes are well determined in parkinson's disease (pd), few studies describe the effects the virtual exercises on the clinical and functional outcomes in this disease. objectives: to analyze the effectiveness of virtual exercises on functional exercise capacity, fatigue and quality of life in patients with pd. methods: 20 subjects, 60 years old will be included, who will be randomized into 2 groups: group of virtual exercises associated with conventional exercises (n = 10) and control group with conventional exercise group (n = 10). the following variables are evaluated: functional exercise through walking test in 6 minutes, fatigue by the fatigue severity scale and quality of life through quality of life questionnaire-pdq-39.


Eligibility criteria:
inclusion criteria: * will be selected for the study * subjects with a clinical diagnosis of parkinson's disease * 0-iii h\&y * 40 to 80 years * both sexes * with preserved cognitive stage (mini mental\> 24). exclusion criteria: * will be excluded subjects who have some acute pain or associated diseases * such as severe or unstable heart disease * visual disturbances * using some march auxiliary device, which compromise the 6mwt and exercise protocol

Keywords: parkinson disease, physical therapy, fatigue, quality of life
distant healing for hiv/aids

Conditions: HIV Infections; AIDS

Summary: the purpose of this study is to determine whether individuals praying at a distance (also known as "distant healing") can positively affect the health of people with hiv/aids.

significant numbers of people with hiv/aids seek spiritual or "psychic" treatment. distant healing could potentially be of benefit to large numbers of hiv/aids patients, as it is widely available and requires no travel or other activity on the part of the patient. however, the treatment can be costly and has not yet been proven effective in a controlled clinical trial. this study will evaluate the efficacy of distant healing in patients with hiv/aids. participants in this study will be randomly assigned to either the distant healing group or a control group. all participants will have hour-long study visits at entry and months 6 and 12. at study visits, participants will complete a demographic questionnaire, self-report health and symptom inventory, quality of life assessment, and profile of mood states. blood will be drawn at each study visit.

Eligibility criteria:
inclusion criteria * hiv infection * history of a cd4 cell count less than 200 cells/mm3 * stable antiretroviral regimen * english-speaking exclusion criteria * inability or unwillingness to fill out questionnaires * history of non-hiv related life-threatening disease

Keywords: aids hiv prayer healing complementary therapies