Kornimate/medical-research-clean huggingface dataset:
efficacy and tolerability cvi (a 12-week, double-blind, randomised, placebo-controlled, multicentre trial (cvi)

Conditions: Venous Insufficiency

Summary: to determine efficacy and tolerability of antistax 360 mg tablets in chronic venous insufficiency linked to edema (swelling) and subjective symptoms


Eligibility criteria:
yoga for adolescent knee pain

Conditions: Anterior Knee Pain Syndrome

Summary: adolescent atraumatic anterior knee pain is a common yet cumbersome diagnosis that is currently managed with home exercises and physical therapy. the goal of this project is to present patients with an alternative treatment in the form of yoga available in an online video format. this new treatment, in the form of online yoga videos, may be more preferred for some patients and allow for higher compliance with home exercises aimed at treating anterior knee pain.

adolescent atraumatic anterior knee pain is a common yet cumbersome diagnosis that is currently managed with home exercises and physical therapy. the goal of this project is to test the compliance and efficacy of an alternative treatment in the form of yoga available in an online video format. this study will help further the treatment understanding of one of the most common patient clinical presentations, atraumatic anterior knee pain in adolescents. this is a cumbersome patient presentation that is frustrating for both the patient and treating team in that there is no concrete treatment algorithm that works for everyone. online yoga videos may be more preferred for some patients and allow for higher compliance with home exercises aimed at treating anterior knee pain. with this study, the investigators hope to ensure that the yoga videos provide equal, or more, pain relief and flexibility at the completion of the program. it is hypothesized that patients completing the yoga program will have equivalent or greater flexibility, compliance, and pain relief when compared with current treatment recommendations for anterior knee pain. this study aims to assess the success of a video-based eight-week home yoga program at improving compliance, increasing flexibility and functionality of knee movements. compliance will be tracked through recorded access to the specific youtube videos hosted through the ctpo youtube channel. anterior knee pain patients will be given a link to two yoga videos and will be asked to do them at home, or wherever convenient for 8 weeks, 3-4 times a week.

Eligibility criteria:
inclusion criteria: * children with non-structural anterior knee pain exclusion criteria: * any intra-articular injuries * no access to internet * non-english speaking

Keywords: adolescent
radiographic prediction of the nerve origin of neck peripheral nerve sheath tumors

Conditions: Peripheral Nerve Sheath Tumors; Schwannoma of Neck

Summary: postoperative nerve palsy is a major complication following resection of neck peripheral nerve sheath tumors. this study is a retrospective cohort aimed to predict the nerve origin of neck peripheral nerve sheath tumors. accurate preoperative identification of the nerve origin can improve surgical outcomes and patient counseling

postoperative nerve palsy is a major complication following resection of neck peripheral nerve sheath tumors (pnsts). accurate preoperative identification of the nerve origin (no) can improve surgical outcomes and patient counseling. this study aims to predict the no of neck pnsts with radiographic analysis. this study is a retrospective cohort analysis. radiographic parameters will be reviewed and the sensitivity, specificity, accuracy of no prediction will be evaluated.

Eligibility criteria:
inclusion criteria: * patients with clinical diagnosis of neck peripheral nerve sheath tumors. * patients received surgery january 2008 and december 2022. * the nerve origin of peripheral nerve sheath tumor must be intraoperatively confirmed. exclusion criteria: * previous anterior neck surgery. * malignant disease. * prior neck radiation. * undetermined intraoperative nerve origin.
neurocognitive outcome in children who suffered from idiopathic increased intracranial hypertension (iih)

Conditions: Prospective Study , Questionaires

Summary: 15 patients, ages 8-17 who were diagnosed in the recent years with idiopathic increased intracarnial hypertension (iih) went through a battery of neurocognitive tests to establish whether there was any affect of the disease on their cognitive function


Eligibility criteria:
inclusion criteria: * children who suffered from iih based on history, physical examination, ophtalmological exam, lp results, brain imagining exclusion criteria: * co morbidities
a clinical trial to evaluate the toxicity and antiviral effects of a range of doses of ampligen in p24 antigen positive hiv-infected patients with aids or arc

Conditions: HIV Infections

Summary: to determine the safety of intravenous infusion of ampligen in symptomatic hiv-infected patients at several dose levels, to determine the maximum dose that can be tolerated, and to measure the effects of ampligen on the hiv virus infection, immune function, and clinical condition. ampligen is a suitable drug for clinical trials against hiv because it has been shown to stimulate the immune system and to inhibit replication of hiv in vitro at doses that can be achieved without noticeable harmful side effects.

ampligen is a suitable drug for clinical trials against hiv because it has been shown to stimulate the immune system and to inhibit replication of hiv in vitro at doses that can be achieved without noticeable harmful side effects. patients entered in the study are given ampligen by intravenous infusion at hemophilia treatment centers once during the first week of the trial and twice a week during the following 12 weeks. the dose each patient receives is determined by the responses of earlier patients. if the status of the hiv infection does not improve after the first 13 weeks, ampligen will be stopped. each patient maintains a daily diary listing any symptoms or problems that occur such as headache, nausea, or change in appetite. other anti-hiv drugs cannot be taken during the trial, and aspirin or acetaminophen should not be taken for more than 72 hours at any time during the trial without consulting the research staff. blood will be drawn at intervals during the 13-week trial and 8-week follow-up and used to determine the effect of ampligen on hiv and the immune system as well as to monitor toxicity and side effects.

Eligibility criteria:
inclusion criteria hemophiliacs are included. patients must have: * consistently positive serum hiv p24 antigen (= or \> 70 pg/ml) defined by the abbott hiv antigen test. this demonstration must be seen on two occasions, each separated by at least 72 hours, the last of which must be within 2 weeks of starting therapy. * positive hiv antibody test. prior medication: allowed: * acyclovir for short course (7 days). * ketoconazole for short course (7 days). * aerosolized pentamidine for pneumocystis carinii pneumonia (pcp) prophylaxis. * trimethoprim / sulfamethoxazole for pcp prophylaxis. exclusion criteria co-existing condition: patients with aids encephalopathy as a sole indicator are excluded. patients with aids encephalopathy as a sole indicator are excluded. prior medication: excluded: * other experimental medication. * antineoplastic therapy. * amphotericin b. * ganciclovir. * excluded within 14 days of study entry: * biologic modifiers. * corticosteroids. * excluded within 30 days of study entry: * other antiretroviral agents. * excluded within 60 days of study entry: * ribavirin. active drug or alcohol abuse.

Keywords: virus replication t-lymphocytes infusions, intravenous immunologic surveillance acquired immunodeficiency syndrome ampligen aids-related complex antiviral agents
r-eswt in moderate knee osteoarthritis

Conditions: Orthopedic Disorder

Summary: this study aims to compare the efficacy of r-eswt treatment with sham-eswt on pain, walking speed, physical function, and isokinetic muscle strength in knee osteoarthritis.

extracorporeal shock wave therapy (eswt) has been increasingly used to help relieve pain and to remedy musculoskeletal disorders in recent years. eswt seems to be an effective treatment modality many different musculoskeletal conditions, including rotator cuff tendinopathies, calcifying tendinopathy of the shoulder, lateral epicondylitis, greater trochanteric pain syndrome, patellar tendinopathy, achilles tendinopathy, plantar fasciitis, and bone disorders. eswt seems to have chondroprotective, anti-inflammatory, neovascularization, anti-apoptotic, and tissue regeneration effect on tissues which could be relevant in the treatment of oa.

Eligibility criteria:
inclusion criteria: * knee oa according to american college of rheumatology (acr) diagnostic criteria with kellgren - lawrence (k-l) grade 2 or 3. exclusion criteria: * patients with secondary oa, * severe chronic illness, * poor general health status (heart failure, chronic bronchitis, etc.), * chronic inflammatory diseases, * knee replacement surgery, * prior malignancy

Keywords: r-eswt knee osteoarthritis pain function
assessment of safety and effectiveness of biodegradable temporizing matrix in the treatment of deep burn skin injuries

Conditions: Burns

Summary: this is a multi-center, single arm, traditional feasibility study to allow a preliminary assessment of the safety and effectiveness of a new method of treating skin burns using biodegradable temporizing matrix (btm).

this is a multi-center, single arm, traditional feasibility study to allow a preliminary assessment of the safety and effectiveness of btm treatment. patients with 10-70% tbsa burns will have btm devices implanted in areas with deep partial or full thickness burns to treat at least 5% tbsa.

Eligibility criteria:
inclusion criteria: * provides written informed consent (directly or via legal representative) prior to any clinical trial procedures being performed. * willing to comply with all study procedures and expects to be available for the duration of the study. * male and non-pregnant females ≥ 18 years of age and ≤ 70 years of age. * patients with deep partial or full thickness burns (between 10% and 70% inclusive of their tbsa). exclusion criteria: * has a known hypersensitivity to polyurethane or silver-containing materials. * multiple traumas (significant traumatic injury to a solid organ in addition to skin). * presence of a medical condition with a life expectancy of less than 12 months, such as advanced malignancy. * presence of a medical condition that might interfere with treatment evaluation; or require a change in therapy including but not limited to, significant immune deficiency, or skin or vascular diseases in the area of the wound. * female with known or suspected pregnancy, planned pregnancy, or lactation. * has had exposure to any other investigational agent within the last 6 months. * has a clinically significant psychiatric illness. * has a condition the investigator believes would interfere with the ability to comply with study instructions, or that might confound the interpretation of the study results or put the subject at undue risk.

Keywords: burns autografts humans biodegradable polyurethane dermal matrix synthetic
the effect of the oslo sports trauma research center (ostrc) injury prevention exercises reducing injuries rate among athletes.

Conditions: Sport Injury

Summary: the oslo sports trauma research center (ostrc) was established in may 2000 at the norwegian school of sport sciences.the ostrc aims to prevent injuries and other health problems related to sports. the majority of the research conducted at ostrc involves elite sports. the purpose of this study is to investigate the effect of the oslo sports trauma research center (ostrc) injury prevention program in reducing injuries among athletes. hypothesis: that oslo sports trauma research center (ostrc) injury prevention program has a beneficial effect in terms of injury prevention. the purpose of this study is to investigate the effect of the oslo sports trauma research center (ostrc) injury prevention program in reducing injuries among athletes.

study type interventional description of intervention(s) / exposure: the intervention group will be instructed to include the oslo sports trauma research center (ostrc) injury prevention program as a warm up before training session (3 times per week) during one season (6 months). group sessions will be administered by an exercise physiologist and/ or athletic trainer and/ or soccer coaches and/ or strength and conditioning specialists and/ or physiotherapist. session attendance checklists will be used to assess or monitor adherence to the intervention. comparator / control treatment the control group will practice their usual warm up. usual warm up is defined as any basic exercises performed before a performance or practice to prepare the muscles for vigorous actions.

Eligibility criteria:
inclusion criteria: * healthy * amateur athletes * training at least three times per week exclusion criteria: * history of lower extremity injury requiring medical attention in the past 6 months * systemic diseases * cardiovascular disease * neurological disorders * bone fractures * surgery in the previous year.

Keywords: oslo sports trauma research center injury prevention program
corneal biomechanics and corneal reshaping therapy

Conditions: Myopia

Summary: the aim of the proposed study is to investigate the predictive value of corneal biomechanical properties in corneal reshaping therapy and the role of these parameters in determining the amount of myopia reduction.

experiment 1: to evaluate changes in corneal biomechanics caused by short-term corneal reshaping therapy. subjects will wear a conventional rgp lens in one eye, randomly selected, and an orthokeratology lens in the fellow eye, for 30 minutes, 60 minutes and one night, respectively. corneal stiffness and tangent modulus will be measured before and after each wearing period. experiment 2: to evaluate changes in and the recovery of corneal biomechanics effected by long-term corneal reshaping and to assess whether corneal biomechanics can predict the rate of corneal reshaping. subjects will wear orthokeratology lenses for 6 months. regular follow up visits (1 week, 1 month, 3 months and 6 months) will be arranged to monitor the changes in corneal stiffness and tangent modulus.

Eligibility criteria:
inclusion criteria: * myopia between -4d to -5d, with-the-rule astigmatism not more than 1.5d, spherical equivalent between -4d to -5.75d, difference between two eyes within 1d, best corrected spectacle visual acuity 0.10 logmar in each eye exclusion criteria: * previous corneal reshaping therapy, long-term contact lens wear, ocular disease

Keywords: corneal reshaping therapy corneal biomechanics
characterisation of gut microbiota, bispectral index data and plasma kynurenine in patients undergoing video-assisted thoracic surgery

Conditions: Lung Cancer

Summary: the study is a case-controlled observational trial. sixty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night bispectral index data. firstly, this study aims to characterise the gut and lung microbiota in patients with lung cancer treated with surgery. secondly, it aims to evaluate microbiota and its influence on plasma kynurenine.

the study is a case-controlled observational trial. sixty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night bispectral index data. firstly, this study aims to characterise the gut and lung microbiota in patients with lung cancer treated with surgery. secondly, it aims to evaluate microbiota and its influence on plasma kynurenine.

Eligibility criteria:
inclusion criteria: * 1. ethnic chinese; * 2. age, 18 to 75 years old; * 3. american society of anaesthesiologists (asa) physical status i or ii; * 4. required vats for lung surgery and one lung ventilation . exclusion criteria: * cognitive difficulties * partial or complete gastrectomy * previous esophageal surgery * previous treated by radiotherapy or surgery * inability to conform to the study's requirements * body mass index exceeding 30 kg/m2 * deprivation of a right to decide by an administrative or juridical entity * ongoing participation or participation in another study \<1 month ago * preoperative pittsburgh sleep quality index global scores higher than 6 * recent (\< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, laxatives, proton pump inhibitors, insulin sensitizers or traditional chinese medicine
radicle relief 1: a study of health and wellness products on pain and other health outcomes

Conditions: Pain; Nociceptive Pain; Neuropathic Pain

Summary: a randomized, blinded, placebo-controlled study assessing the impact of health and wellness products on pain and other health outcomes

this is a randomized, blinded, placebo-controlled study conducted with up to 300 adult participants per study arm, age 21 and older and residing in the united states. eligible participants will (1) endorse a desire for less pain, (2) indicate an interest in taking a health and wellness product to potentially help relieve their pain, and (3) express acceptance in taking a product and not knowing its formulation until the end of the study. participants with known liver or kidney disease, heavy drinkers, and those who report they are pregnant, trying to become pregnant, or breastfeeding will be excluded. those taking certain medications will be excluded. self-reported data are collected electronically from eligible participants over 5 weeks. participant reports of health indicators will be collected during baseline, throughout the active period of study product use, and in a final survey. all study assessments will be electronic; there are no in-person visits or assessments for this real-world evidence study

Eligibility criteria:
inclusion criteria: * adults, 21 years of age and older at the time of electronic consent, inclusive of all ethnicities, races, genders and/or gender identities * resides in the united states * endorses pain as a primary issue (desire for less pain) * selects their desire for less pain and/or reduce reliance on medications as a reason for their interest in taking a health and wellness product * expresses a willingness to take a study product and not know the product identity (active or placebo) until the end of the study exclusion criteria: * reports being pregnant, trying to become pregnant, or breastfeeding * unable to provide a valid physical shipping address * reports a diagnosis of liver or kidney disease * reports being a heavy drinker (defined as drinking 3 or more alcoholic beverages per day) * unable to read and understand english * lack of reliable daily access to the internet * reports taking anticoagulants, any medication that warns against grapefruit consumption, corticosteroids at doses greater than 5 mgs per day, or maois * reports current or recent (within 3 months) use of chemotherapy, immunotherapy, or oral anti-infectives (antibiotics, antifungals, antivirals) to treat an acute infection
improvement of the accuracy of spatial representation of invasive exploratory electrodes in focal epilepsy

Conditions: Focal Epilepsy

Summary: reconstruction software allows visualization of cortical structure in 3 dimensions, showing on a single picture the position of all the electrodes. the eeg signal of each recording plot of the electrode is analyzed and compared with the underlying brain structure reconstructed by the software. it is therefore possible to visualize 1) ictogenic and epileptogenic areas using neurophysiological stereoelectroencephalography (seeg) data and 2) adjacent functional cortical areas with functional imaging and seeg. software makes it possible to determine the links between these areas. this study aims to show that using these software is an asset in surgical decision and in the choice of surgical strategy. each patient has presurgical evaluation (usual care), including morphologic and (if necessary) functional mri, eeg and seeg. in this study, software will be used to analyze the processed data (fsl software, fmrib laboratory, oxford university and brainvisa/anatomist. the surgical decision will be taken according to the usual staff procedures, based on the usual examination results. after the decision making process, the staff will be asked to reconsider the surgical decision, according to the analysis provided by the software. the discrepancies between the decisions will be recorded.


Eligibility criteria:
inclusion criteria: * children aged 18 months to 17 years old * drug resistant focal epilepsy * scheduled for deep brain electrodes exploration to assess surgical indication exclusion criteria: * contraindication to anesthesia or surgery * refusal (of parents or child) to participate in the study * no health insurance coverage
tailoring cpp for the foster care setting

Conditions: Behavior Problem

Summary: the primary objective of this study is to tailor the chicago parent program, an evidence-based parent training program, for the foster care setting and pilot the content in two cohorts of foster and kinship caregivers (gross et al., 2009).

this study involves the administration of an evidence-based prevention program to prevent and reduce behavior problems in young children (the chicago parent program; cpp). cpp will be tailored by creating additional handouts, discussion questions, and topics that contextualize cpp material to foster care, to meet the needs and social norms of foster and kinship caregivers. the cpp-fc 12-session curriculum will be delivered to two cohorts of foster and kinship caregivers virtually. data for this study will come from multiple sources, including caregiver participant report and a review of existing electronic databases at cchmc.

Eligibility criteria:
inclusion criteria: * must be a licensed foster caregiver or kinship caregiver to a child ages 2 years to 8 years * must be in good standing with the foster care agency * must be english-speaking exclusion criteria: * not having a foster child ages 2 - 8 years in the home * caregiver is unable to commit to participating in cpp-fc * this foster child age 2 - 8 years was placed in the home more than 45 days prior to enrollment

Keywords: foster care child behavior parenting skills behavioral health
hcap18 levels and vitamin d deficiency in healthy subjects

Conditions: Healthy Subjects; Vitamin D Deficiency

Summary: vitamin d deficiency (low levels of vitamin d in the blood) is a common problem. a recently discovered protein, called hcap18, likely plays an important role in the immune system and may depend on adequate levels of vitamin d. it is not known what levels of vitamin d are needed to allow the body to make this protein. nor is it known if giving vitamin d to people who are found to be deficient will help boost levels of hcap18. this study aims to clarify the relationship between vitamin d levels and hcap18.


Eligibility criteria:
inclusion criteria: * age 18-80 exclusion criteria: * known active infectious disease or chronic inflammatory disorder * hypercalcemia * chronic kidney disease * pregnancy