Kornimate/medical-research-clean huggingface dataset:
warming blanket comparison study

Conditions: Surgery; Temperature Change, Body

Summary: the purpose of the study is to compare the effectiveness of resistive blanket warming to forced air warming in maintaining body temperature in participants undergoing renal transplantation.

the study will involve two arms: a resistive blanket warming system arm and a forced air warming system arm. both devices will be set to warm the participant at a standard 41 degrees celsius when the participant is to be rewarmed. during the study, the forced air warming system (faws) will be placed on the (resistive blanket warming system (rbws), with the participant laying on top of the forced air warming system. the arm components will be wrapped around the participant's arms to assist with patient positioning for surgery. both the forced air and resistive blanket warming systems will be attached to their respective heating units before the participant is brought to the or and transferred to the operating room table. after the needed standard monitors for surgery have been placed, general anesthesia will be induced and maintained with participant's hemodynamics and other vitals maintained per standard care (no additional measurements beyond standard of care which is recorded in epic). the certified registered nurse anesthetists (crna) will be involved in the placement of the blankets. operating room nurse managers and crna's will be informed by research team regarding participant's involvement in the study. participant's core temperature will be measured with a nasopharyngeal temperature probe. vital signs, including continuous blood pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide, will be monitored and recorded in epic as is routine with all anesthetics performed. standard anesthetic care of the participant will occur for the duration of the surgery. the participant will be randomized to either the faws or rbws before arrival to the operating room. the participant's temperature will be monitored and recorded for the duration of surgery with the selected warming system. the primary outcome variable is the nasopharyngeal temperature as recorded at the end of the surgery. temperature measurement in the pacu will be standardized with skin temperature probes that will be placed on the forehead prior to leaving the operating room.

Eligibility criteria:
inclusion criteria: - undergoing elective renal transplantation exclusion criteria: * previous surgery involving organ transplantation or nephrectomy. these patients are at higher risk of blood loss, making temperature regulation subject to more variables outside our control. * end stage renal disease with decreased or no urine output from normal. bladder temperature will not be valid in these patients. * previous upper extremity amputations * ongoing sepsis or other infection * thyroid dysfunction * emergency surgery * refusal of consent to participate in study * pregnancy
study of the effect of a cognitive task on static balance in depressive elderly subjects according to the double task principle

Conditions: Depression

Summary: this study could contribute to understanding the aggravation of balance disorders and the increased risk of falling in depressive people. it could, among other things, shed light on the impact of treatments with antidepressants on balance in treated depressive patients. finally, it could contribute to improving the sensory-motor management of patients with a depressive syndrome.


Eligibility criteria:
inclusion criteria: in the 2 groups: * general and cognitive status allowing the patient, according to the evaluation of the investigators, to take part in the study. * patients who provide written informed consent * patients covered by the national health insurance agency in the "depression " group: * age ≥ 75 years, * subjects with a depressive syndrome, according to geriatric depression scale criteria. * patients without treatment with antidepressants in the "control" group: * age ≥ 75 years, * absence of a depressive syndrome exclusion criteria: in the 2 groups: * presence of a disabling orthopedic disease, * presence of any chronic neurological disease (cerebrovascular accident, parkinson's syndrome ...), * presence of a psychiatric disease apart from depression in the " depression " group * presence of a vestibular disease with clinical manifestations, * presence of a non-corrected visual disorder, * existence of a progressive organ disease, * psychotropic treatment able to impair vigilance and posture, * notion of one or several falls in the preceding 6 months, * oppositional personality or low motivation, * emotional or intellectual disorder. * patients under guardianship * patients who have taken part in a therapeutic trial in the previous 30 days
comparison of two brief mindfulness intervention for stress, anxiety and burnout in mental health professionals

Conditions: Mental Health Wellness 1

Summary: the aim of this study is to examine the effectiveness of two mindfulness interventions for stress, anxiety and burnout in mental health professionals. participants will receive the treatments in reverse order: a brief intervention based on body-centered exercises and another brief intervention based on sitting meditation. it is hypothesized that both interventions will decrease stress and anxiety levels and professional burnout, with mindfulness body-centered exercises being at least as effective as mindfulness meditations.

the aim of this study is to examine the effectiveness of two mindfulness interventions for stress, anxiety and burnout in mental health professionals. it is a 2-sequence, 2-period, 2-treatment crossover design with sequences ab and ba. treatment a consists of a block of five sessions of bodyfulness exercises, whereas experimental treatment b consists of a block of five sessions of sitting mindfulness meditation exercises. in the sixth session, the exercise blocks will be exchanged. each group will be composed of half the sample, with a initial sample of 130. the principal hypothesis is that both interventions will decrease stress and anxiety levels and professional burnout, with body-centered exercises being at least as effective as mindfulness sitting meditations. secondarily, the personality type will be analyzed as a moderating variable in those variables in which the interventions will be effective. third, a qualitative study will be conducted in order to analyze the perceptions of change and experiences in cuban mental health professionals who are beginner meditators. this study will allow to understand the differential effectiveness of bodyfulness and midfulness and what types of personality may benefit most from different types of meditation interventions. also, it will hell to get a deeper understanding of mindfulness practice in a new cultural context (i.e., cuba). a previous pilot study will be conduct to investigate the acceptability and effectiveness of a culturally-adapted mindfulness-based intervention in cuba.

Eligibility criteria:
inclusion criteria: * to be a full time mental health professional * to be 18 years or older * to be able to attend weekly sessions exclusion criteria: * to suffer a pathology that discourages participation in the study. * previous training in mindfulness

Keywords: mindfulness meditation stress burn-out personality randomized controlled trial
yobeka program (yoga, movement, relaxation, concentration and mindfulness) in elementary schools

Conditions: Stress, Psychological

Summary: the aim of this study is a first evaluation of the effectiveness of the yobeka program (yoga, movement, relaxation, concentration and mindfulness) to evaluate potential effects in stress reduction and concomitant psychological parameters.


Eligibility criteria:
inclusion criteria: * students from participating primary schools in berlin aged 6-12 years * written declaration of consent of the parent or legal guardian exclusion criteria: * serious chronic or acute diseases * immobility or serious restriction for gymnastic exercises due to orthopaedic, neurological or other medical causes * participation in another study
fitness trackers during and after oncological treatments

Conditions: Cancer; Physical Activity; Fatigue

Summary: the overall goal of the present trial is to evaluate the patients' compliance for wearing a commercially available fitness tracker during and after oncological treatments.


Eligibility criteria:
inclusion criteria: * histologically confirmed malignant disease * upcoming chemotherapy of radiochemotherapy * eastern co-operative oncology group (ecog) performance score 0-2 exclusion criteria: * pre-existing comorbidities that impair patient mobility. * eastern co-operative oncology group (ecog) performance score 3-4
growth hormone treatment of women with turner syndrome

Conditions: Turner Syndrome

Summary: growth hormone treatment is used in girls with turner syndrome to increase final height. the aim of this study is to evaluate the effect of growth hormone treatment on body composition and heart function in adult women with turner syndrome. the hypothesis is that the fat mass will decrease and lean body mass will increase. there is only very limited documentation of the effect on the heart in this study population.

this study is a randomised, double-blinded, controlled clinical trial to evaluate the effect of growth hormone (gh) treatment on adult women with turner syndrome. the endpoints will be changes in body composition and heart function evaluated by echocardiography (echo) and positron emission tomography (pet). phase one: 6 months of gh or placebo treatment. phase two: "open label" all participants are treated with gh for 12 months. at baseline, healthy controls will be examined, but will not receive any treatment

Eligibility criteria:
inclusion criteria: * turner syndrome * age 20-40 exclusion criteria: * symptomatic heart disease * anti hypertensive treatment * untreated thyroid disease * adipositas (bmi \> 35) * treatment with glucocorticoids * pregnancy

Keywords: turner syndrome growth hormone treatment positron emission tomography heart
brain health project for korean american dementia caregivers

Conditions: Caregiving Stress

Summary: the caregivers of persons with dementia face significant emotional, physical, and financial challenges, particularly among under-resourced communities like korean americans, who encounter unique obstacles, including language barriers and limited culturally tailored resources. in this pilot study, the investigators propose the brain health project, which focuses on increasing knowledge of alzheimer's disease and related dementia and enhancing caregiving skills among korean american dementia caregivers.


Eligibility criteria:
inclusion criteria: * age 18 and older * self-identified as korean american * able to read and/or speak english or korean * care for a person with undiagnosed or diagnosed dementia for the last 6 months * have access to a mobile phone to receive text messages exclusion criteria: * planning a trip out of the united states during the next four months
bladder cancer and neoadjuvant chemotherapy efficiency before cystectomy

Conditions: Bladder Cancer; Genomic Instability

Summary: this study will allow the investigators to better assess the efficiency of neoadjuvant chemotherapy before cystectomy by training a predictive model on different patient cohorts with bladder cancer.

the project is based on three prospective cohorts of patients with mibc: the vesper trial (n=296), the st-louis hospital cohort (n=99), and the coblance cohort (n=312). using wes and rnaseq, the investigators will determine genomic instability, ddr gene mutation and molecular subtypes. after digitization of tumour slides, the investigators will train and test predictive models based on deep learning approaches to predict outcome after neoadjuvant chemotherapy, either by estimating molecular subtypes and genetic features from pathological images, or by directly defining a prognostic signature. the statistical analyses will assess the performance of the models combining genomic instability, dna damage response mutations and/or molecular subtyping to predict outcome after neoadjuvant chemotherapy and compare them with the models based on wsi deep learning approaches. these results will help to design new therapeutic strategies.

Eligibility criteria:
inclusion criteria: - inclusion criteria of patients enrolled in vesper study: blood and tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine included in vesper cohort and : having signed an informed consent form for the participation to the collection or dead/lost to follow-up without prior opposition expressed against research program, genetic analysis will only be carried out for patients who have signed the genetic consent form. - inclusion criteria of patients from st louis cohort not enrolled in vesper study: blood and tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine included in saint-louis cohort and : being informed for the participation to the collection and not having expressed opposition against research program or dead/lost to follow-up without prior opposition expressed against research program, - inclusion criteria of patients from st louis cohort not enrolled in coblance study: blood and tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine included in coblance cohort and : being informed for the participation to the collection and not having expressed opposition against research program or dead/lost to follow-up without prior opposition expressed against research program, exclusion criteria: * patients not fulfilling eligibility criteria

Keywords: neoadjuvent chemotherapy molecular subtype bladder cancer genomic instability artificial intelligence
comparison of dexmedetomidine and remifentanil infusion during cabg

Conditions: Coronary Artery Bypass Graft; Hypokalemia; Cardiac Arrhythmia; Dexmedetomidine; Remifentanil

Summary: we are trying to investigate whether intraoperative dexmedetomidine infusion could decrease the incidence of intraoperative hypokalemia and arrhythmia, and myocardial injury in patients undergoing off-pump coronary artery bypass graft, and trying compare these effects with those of remifentanil infusion.

alpha2-adrenergic agonist, dexmedetomidine, is recently used for sedation, analgesia or adjuvant to general anesthesia. postsynaptic activation of alpha2 adrenoceptors in the central nervous system (cns) inhibits sympathetic activity and thus can decrease blood pressure and heart rate. the blockade of sympathetic activity decrease the neuroendocrine stress response and may decrease the incidence of hypokalemia. the hypokalemia can increase the incidence of arrythmia, especially in cardiac patients. we postulated that dexmedetomidine could decrease the neuroendocrine stress response, thus decrease arrhythmia during cardiac surgery. furthermore, dexmedetomidine have been reported to have cardioprotective effect with previous animal studies. therefore, the aim of the present study is to investigate whether the intraoperative dexmedetomidine infusion can reduce the incidence of hypokalemia and arrythmia, and myocardial injury in subjects undergoing off-pump coronary artery bypass graft. we are also trying to compare these effects with those of remifentanil infusion.

Eligibility criteria:
inclusion criteria: * those undergoing off-pump coronary artery bypass graft during march, 2012 \~ february, 2013 in samsung medical center * age between 20 and 70 yrs old exclusion criteria: * any patients with plasma aldosterone, or glucocorticoid disorder including primary hyperaldosteronism, renovascular hypertension, rennin-secreting tumor, salt-wasting renal disease, cushing syndrome * patients with recent exogenous steroid administration or previous diuretics therapy

Keywords: coronary artery bypass graft hypokalemia cardiac arrhythmia dexmedetomidine remifentanil
increasing risk perception of physical activity using patient-targeted feedback.

Conditions: Hypertension; Coronary Disease; Cardiac Diseases

Summary: the aim of this study is to evaluate the efficiency of a minimal intervention on risk perception of physical inactivity in patients with known coronary heart disease (chd) and patients at risk for chd. therefore half of the patients (intervention group) get a personal feedback on their individual level of physical activity measured by pedometers and self-report questionnaires plus information about the risk factor 'physical inactivity' for heart diseases. following the hypotheses the feedback should increase the patients risk perception of physical inactivity and furthermore increase physical activity.


Eligibility criteria:
inclusion criteria: * known coronary heart disease or at least 2 risk factors for coronary heart disease * age: 18 years up to 75 years * sufficient language skills * access to a telephone * willingness to participate in telephone interviews * "informed consent" exclusion criteria: * life threatening health status * severe somatic or/and psychological disorder that needs urgent treatment * hospital stay within the last 7 days * surgical intervention plus hospital stay for at least 3 days within the last 2 months * myocardial infarction within the last 3 month * musculoskeletal diseases, which have a strong influence on physical activity * severe cognitive or/and visual difficulties

Keywords: physical activity patient feedback risk perception pedometer
chart review of xen 45 gel stent: long term performance and safety assessment (xen lt)

Conditions: Glaucoma

Summary: a retrospective, non-interventional, observational, multi-center, chart review study to be conducted in participants who underwent placement of the xen 45 gel stent as a standalone procedure or in combination with phacoemulsification from 1 january 2014 to 1 october 2015.


Eligibility criteria:
inclusion criteria: * eye treated with xen 45 gel stent for primary open angle glaucoma as a standalone procedure or in combination with phacoemulsification * xen 45 gel stent was implanted between 1 january 2014 and 1 october 2015 exclusion criteria * none
project cope:managing dementia at home

Conditions: Dementia, Alzheimer Type

Summary: this study tests the effectiveness of an in-home intervention to reduce upset and burden among family caregivers, and decrease nursing home placement. the main hypothesis that will be tested is that compared to control group, subjects, experimental group participants will have enhanced well-being and fewer nursing home placements.

implement a multi-component in-home intervention designed to prevent and ameliorate the troublesome behaviors that families typically confront and that often trigger nursing home placement. the intervention combines the most effective strategies that have been identified in previous caregiver research by the investigative team and best clinical practices to provide a comprehensive service approach to families and individuals with dementia including education, skills training, home safety, and stress management. to enhance its applicability to real-world practice within the aging service network, the intervention is designed to be reproducible and its components and treatment goals commensurate with the medicaid waiver program. in the absence of evidence-based service protocols currently in place for this waiver population, the intervention, if effective, would provide a systematic, evidence-based approach in the medicaid waiver program to help families and persons with dementia remain at home and in their communities.

Eligibility criteria:
inclusion criteria: * care-recipients must have a mmse score \< 24 and a diagnosis of dementia, live in the community, and either need help with one or more daily activities and/or have one or more behavioral occurrences. caregivers must be a relative, at least 21 years of age, be english speaking, have a telephone, either live with the care-recipient (cr) or spend at least 48 hours per week in direct oversight or caring for him/her; plan to live in the area for 9 months, report upset with cr function dependence or behavioral occurrences. exclusion criteria: * the cg-cr dyad will be excluded if cr has had more than 3 hospitalizations within the past 12 months, are in treatment for life-threatening cancer, have schizophrenia or a bipolar disorder, have dementia secondary to head trauma, have a mmse score = 0 and are bed-bound (defined as confinement to bed or chair for at least 22 hours a day for at least four of the previous seven days); or they are enrolled in a clinical trial of pharmacological treatment for agitation. also, the dyad will be excluded if the cg had more than 3 hospitalizations within the past 12 months or is in treatment for life-threatening cancer; is involved in another clinical trial of psychosocial or educational interventions for caregivers; or plans to place their family member in a nursing home within the next 9-months.

Keywords: caregivers in-home care occupational therapy
an innovative silicone wound dressing for the management of atrophic vaginitis

Conditions: Atrophic Vaginitis

Summary: the objective of the study is to determine the efficacy of 7-0940 in the management of atrophic vaginitis in female patients


Eligibility criteria:
inclusion criteria: * able to provide informed consent * diagnosed acute or chronic atrophic vaginitis * controlled disease, or uncontrolled disease that did not respond to standard therapy with hrt exclusion criteria: * unable to provide informed consent * patient unable to apply topical device * allergy or intolerance to ingredients or excipients of the formulation of studied products * currently on hrt (orally or topically) * currently on corticosteroid treatment