Kornimate/medical-research-clean huggingface dataset:
biofeedback to ameliorate freezing of gait

Conditions: Parkinson's Disease

Summary: the freezing burden will be quantified in subjects with parkinson's disease (pd)before and after 6 weeks of training. two types of interventions (20 subjects in each group) will be tested: 1) open-loop group (olg); 2) closed-loop group (clg). each session of the olg training includes walking courses aimed at provoking freezing episodes. the experimenter will trigger an auditory rhythmic stimulation (ras) in walking conditions likely to invoke freezing (e.g., turning) and the subject will learn to synchronize his/her gait with the auditory cues, i.e., to keep the walking pace and coordination and, as a result, to avoid freezing. similar principles will apply for the clg training; however, the ras will be elicited automatically by a device that recognizes an approaching freezing episode.

the freezing burden will be quantified in subjects with pd before and after 6 weeks of training. two types of interventions (20 subjects in each group) will be tested: 1) open-loop group (olg); 2) closed-loop group (clg). each session of the olg training includes walking courses aimed at provoking freezing episodes. the experimenter will trigger an auditory rhythmic stimulation (ras) in walking conditions likely to invoke freezing (e.g., turning) and the subject will learn to synchronize his/her gait with the auditory cues, i.e., to keep the walking pace and coordination and, as a result, to avoid freezing. similar principles will apply for the clg training; however, the ras will be elicited automatically by a device that recognizes an approaching freezing episode. we anticipate that after intensive training, the central nervous system (cns) of subjects with pd will be able to anticipate impending freezing episodes based on awareness of the environmental conditions (e.g., an approaching turn) and/or based on sub-conscious response to a deteriorating gait pattern. as a result, an automated motor response that paces and coordinates gait will be internally triggered by the cns and the approaching freezing episode will be averted. the overall freezing burden will therefore decrease in trained subjects.

Eligibility criteria:
inclusion criteria: 1. have a diagnosis of pd. 2. suffer from the freezing of gait (fog) symptoms. subjects must score 2 or more on item #3 of the subjective fog questionnaire (fog-q) and exhibit two or more fog episodes during a short, functional fog evaluation procedure that includes fog-provoking conditions (e.g., turns, doorways) and 5 laps of walking in a figure 8 shaped trajectory. 3. able to walk unassisted for at least 5 minutes with ample rest. exclusion criteria: 1. having serious co-morbidities or acute illness that would make training inappropriate. 2. have had brain surgery.

Keywords: parkinson's disease freezing of gait
safety of the sputnik v vaccine in health personnel of private effectors of the city of buenos aires, argentina

Conditions: COVID-19

Summary: the main of the study is to describe the incidence in health personnel who present events supposedly attributed to vaccines and immunizations after having received the two components of the sputnik v vaccine, with the information obtained thanks to the participation of health workers in actively reporting their health status.

the world health organization (who) recommends vaccination against coronavirus disease 19 (covid-19) as a fundamental primary prevention tool to limit the health and economic effects of the pandemic. having effective and safe vaccines in the short term,will help to reduce the incidence of illness, hospitalizations and deaths related to covid-19 and help to gradually restore a new normality in the functioning of our country. on december 23, within the framework of law 27573, the national administration of medicines, food and medical technology submitted the report on the sputnik v vaccine to the ministry of health of the nation to advance in the emergency authorization. the national government ensures the processes to reach the standards of safety and efficacy for the entire argentine territory, being vaccination in stages, free, voluntary and independent of the history of having suffered the disease. for the surveillance of vaccine safety, the strategic plan proposes to health effectors "to develop a specific plan for intensified passive and active surveillance of vaccine safety, which allows the continuous analysis of the notifications of events supposedly attributed to vaccines and immunizations. the ministry of health of buenos aires city articulated the public and private effectors for the epidemiological follow-up of the personnel vaccinated with the first vaccines in relation to the frequency of events supposedly attributed to vaccines and immunizations. the main of the study is to describe the incidence in health personnel who present events supposedly attributed to vaccines and immunizations after having received the two components of the sputnik v vaccine, with the information obtained thanks to the participation of health workers in actively reporting their health status.

Eligibility criteria:
inclusion criteria: * health workers who agree to receive the sputnik v vaccine exclusion criteria: * health workers who have a contraindication to receive the sputnik v vaccine

Keywords: population surveillance covid-19 vaccines adverse effects
cholesterol and fatty acid synthesis in islet and liver transplant patients and effect of dietary intervention

Conditions: Immunosuppression; Hyperlipidemias; Diabetes Mellitus, Type 1

Summary: the purpose is to investigate possible mechanisms of increased blood lipid levels following transplantation, and also to see if a comprehensive dietary intervention is effective in reducing blood lipid levels in post-transplant patients.

post-transplantation patients frequently have an increase in blood lipid levels presumed to be due to immunosuppressive agents, however it is currently unknown the mechanisms by which this occurs. dietary interventions have frequently been unsuccessful in these patients, which may be due to single-nutrient interventions and lack of support and guidance. this research will use stable isotope methods to estimate cholesterol and fatty acid synthesis to determine if these pathways are affected by immunosuppression in patients before and after islet and liver transplant. in addition, it will be determined if a multi-nutrient dietary intervention will be implemented post-transplant can reduce blood lipid levels in to prevent further polypharmacy these patients.

Eligibility criteria:
inclusion criteria: * on islet or liver transplant list * post-transplant \>3 months * physically able to participate in study and intervention exclusion criteria: * \< 18 years of age * family history of premature cardiovascular disease or familial hyperlipidemia (control subjects) * cholestatic diseases (liver transplant patients) * type 2 diabetes

Keywords: type 1 diabetes transplants immunosuppression hyperlipidemia nutrition therapy
a comprehensive care programme for patients with chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: objective: chronic obstructive pulmonary disease (copd) is a disease with significant morbidity and incurs heavy utilization of healthcare resources. the direct cost of hospital admissions related to copd is the single largest source of expenditure in the public hospital system. this study aims to assess whether a comprehensive care programme can decrease the rate of hospital admissions for copd patients.

design: a randomised controlled trial of patients discharged from hospital after an episode of acute exacerbation of copd. patients will be randomised to the intervention arm or usual care group. setting: tertiary university affiliated hospital. interventions: the intervention group will receive a comprehensive programme which involves inputs from doctors, respiratory nurses and physiotherapists, providing an individualized care plan for each subject. the components in the programme will include optimization of medications, specialist physician follow up, nursing support in education, and physiotherapist support for pulmonary rehabilitation. patients in the intervention group will also receive monthly telephone calls by a respiratory nurse for a period of 1 year to assess their conditions and answer their queries. patients will also be followed up in the respiratory clinic by respiratory specialist once every 3 months for 1 year. the control group will be managed as the usual care. the discharging physician will determine the patients' medication and follow up as in normal practice. all patients will be asked to return for assessments (spirometry, 6 minute walk test, questionnaires on the severity of dyspnoea and quality of life) at baseline and 12 months main outcome measures: the primary endpoint is the hospital readmission rate and the secondary endpoints are the quality of life, mortality, lung function and exercise capacity of the patients.

Eligibility criteria:
inclusion criteria: * patients who are admitted to the prince of wales hospital with aecopd will be screened for this study. * patients with age over 40 years exclusion criteria: * patients with asthma * patients unable to provide informed consent

Keywords: copd comprehensive care
effect of combined interventions on pressure pain threshold

Conditions: Osteo Arthritis Knee

Summary: the effect of mobilizations on decrease of peripheral and central sensitivity has been proven in koa. furthermore, the effect of conservative therapy has also been proven in the increase of pain threshold in koa. however, no study has investigated the effect of these interventions combined till date in koa. the aim of the present study is to investigate the short-term and long-term effect of end-range mobilization in addition to conservative therapy on decrease of pressure pain threshold in koa.

the positive effect of different manual mobilizations have been proven in the management of knee osteoarthritis (koa). pressure pain threshold, as a measure of somatosensory function, is a well-applied measurement technique for the pain perception in koa. the effect of mobilizations on decrease of peripheral and central sensitivity has been proven in koa. furthermore, few studies has revealed the effect of conservative therapy as an effective intervention in the increase of pain threshold. however, no study has investigated the effect of these interventions combined till date in koa, which could give a long-lasting effect in the decrease of sensitization in koa. therefore, the aim of the present study is to investigate the short-term and long-term effect of end-range mobilization in addition to conservative therapy on decrease of pressure pain threshold in koa.

Eligibility criteria:
inclusion criteria: * clinical classification criteria of knee osteoarthritis according to the american college of rheumatology * categorization as end of range problem based on maitland manual therapy * unilateral/bilateral moderate-to-severe symptomatic tibiofemoral koa with radiographic evidence of kellgren-lawrence scale 2 or 3 * pain during weight-bearing activities at least within 6 months * at least 90° knee flexion * sufficient mental status exclusion criteria: * acute inflammation of the knee * total knee replacement in the opposite side * class ii. obesity (body mass index\>35kg/m2) * severe degenerative lumbar spine disease (e.g. spondylolisthesis) * systemic inflammatory arthritic or neurological condition * physiotherapy/balneotherapy attendance or manual therapy within 3 months * intraarticular injections in the prior 12 months * use of walking aid * contraindication for manual therapy * complex regional pain syndrome * cognitive impairment

Keywords: musculoskeletal manipulations osteoarthritis, knee pain threshold conservative treatment
nutrition of urban-poor children

Conditions: Dietary Assessment; Growth; Nutritional Assessment

Summary: the investigators undertook a program to promote the consumption of healthy foods and reduce the prevalence of malnutrition of children below the age of 5 years in an urban-poor community, by 10% year-on-year through nutrition education and the provision of healthy food. the main purpose of the study is to determine the impact of these nutrition intervention programs on the nutritional status of children under-5 in selangor. this retrospective pre-post intervention study will use data collected from 2 previous studies that were carried out between july 2020 to may 2021 (eat healthy project 1.0) and march 2022 to december 2023 (eat healthy project 2.0). the 2 studies had been approved by the medical research and ethics committees of university malaya medical centre (ummc) and the ministry of health, malaysia and registered with the national medical research registry (nmrr). the main outcome measures were: 1. improved dietary practices, in particular, an increase in the proportion of children who meet the minimum dietary diversity score of 5 food groups, post-intervention. 2. an increase in proportion of children consuming fruits and vegetables and a decrease in proportion of children consuming sugar-sweetened foods and beverages post-intervention. 3. a decrease in prevalence of malnutrition - underweight, wasting and stunting. the comparator will be urban-poor children attending a child health clinic who had received nutritional education but no provision of food supplementation.

the primary objectives: 1. to compare dietary diversity practices of children, based on the who 8 food groups and 24-hour dietary recall, pre- and post-intervention. 2. to compare consumption of fresh foods, sugar-sweetened foods and beverages pre- and post-intervention. the secondary objectives: 3. to compare the weight-for-age z-scores of children pre- and post-intervention. 4. to compare the height-for-age z-scores of children pre- and post-intervention. 5. to compare the prevalence of malnutrition: underweight, stunting and wasting pre- and post-intervention.

Eligibility criteria:
inclusion criteria: * children aged under 5 years enrolled at ppr lembah subang 1 or * children aged under 5 years enrolled at the child health clinic, universiti malaya medical center exclusion criteria: * children with low birth weight (\<2.5 kg) * children born pre-term (\<37 weeks gestation) and * children with chronic illnesses or severe malnutrition.

Keywords: dietary diversity food supplement malnutrition in children healthy food choice sugar sweetened beverages and food
a study of the efficacy and safety of brensocatib in adults with moderate to severe hidradenitis suppurativa (hs)

Conditions: Hidradenitis Suppurativa

Summary: the primary purpose of the study is evaluate the effect of brensocatib compared with placebo.


Eligibility criteria:
inclusion criteria: * diagnosis of hs (confirmed by a dermatologist), with a history of signs and symptoms consistent with hs for at least 6 months before the screening visit. * moderate or severe hs defined as a total of ≥6 inflammatory lesions (inflammatory nodules and/or abscesses) for at least 8 weeks before the baseline visit. * hs lesions in at least 2 distinct anatomic areas, 1 of which must be at least hurley stage ii or hurley stage iii at both the screening and baseline visits. exclusion criteria: * draining tunnel count of ≥20 at the baseline visit. * surgical or laser intervention for an hs lesion during the screening period. * clinical diagnosis of papillon-lefèvre syndrome. * participants with an absolute neutrophil count \<1,000/mm3 at the screening visit. * participants having active liver disease or hepatic dysfunction. * have diagnosed periodontal disease under active management by a dentist or expected to have periodontal disease-related procedures within the study period. * received systemic (intravenous or orally \[po\]) antibiotic therapy within 8 weeks before the baseline visit a. doxycycline or minocycline up to 100 mg twice daily is permitted provided the dosing regimen being stable for at least 8 weeks before the baseline visit and is expected to continue. * received po or transdermal opioid analgesics (except tramadol) for any reason within 4 weeks before the baseline visit. * permitted analgesics for hs-related pain have not been at a stable dose regimen for at least 4 weeks before the baseline visit. * received prescription topical therapies for the treatment of hs within 2 weeks before the baseline visit. * received any anti-tumor necrosis factor (tnf)-α/other biologics treatment within 12 weeks or 5 elimination half-lives, whichever is longer, before the baseline visit. * received systemic nonbiologic therapies (eg, corticosteroids and retinoids) for hs within 4 weeks before the baseline visit. * received any immunomodulatory agents within 4 weeks before the baseline visit. note: other inclusion/exclusion criteria may apply.

Keywords: hs
analgesic non inferiority of the thoracic bi-block in comparison with thoracic epidural for vats.

Conditions: Erector Spinae Muscle Plane Block; Serratus Anterior Muscle Plane Block; Video-Assisted Thoracic Surgery; Lung Cancer; Pleural Diseases; Thoracic Epidural; Analgesia; Enhanced Recovery After Surgery

Summary: video-assisted thoracic surgery (vats) is the standard treatment for localized lung cancer. however, there is no consensus on analgesic management in patients undergoing vats. the aim of the study is to compare the analgesic efficacy of thoracic epidural with that a "bi-block" combining an erector spinae muscle plane block (esp) and a serratus anterior block (sap) in patients undergoing vats for lung or pleural surgery. our main hypothesis is that the analgesic efficacy of the bi-block, assessed by morphine consumption, is not inferior to that provided by a thoracic epidural during the first 48 hours after vats. we conducted a age, gender and type of surgery-matched retrospective cohort study in the department of thoracic anesthesia of the montpellier university hospital (france).


Eligibility criteria:
inclusion criteria: * to be over 18. * to be scheduled for vats in the center of the study during the study period. * thoracic epidural analgesia of bi-block analgesia. exclusion criteria: * chronic pain or opioid use before surgery (6 months). * postoperative hospitalization in icu during the first two days. * postoperative surgical complication needing surgical revision during the first two days. * preoperative dementia or other psychiatric disease incompatible with vas pain scoring.

Keywords: regional anesthesia video-assisted thoracic surgery
clinical study on treatment of postmenopausal osteoporosis (kidney deficiency and blood stasis syndrome) with xulin jiangu granules

Conditions: Postmenopausal Osteoporoses

Summary: osteoporosis is a common senile disease with a high incidence. the chinese medicine differentiation treatment has small side effects and can be taken for a long time, which has certain advantages. this project adopts the experience of the person in charge of the project-xulin jiangu granules and clinically collects patients with postmenopausal osteoporosis (kidney deficiency and blood stasis syndrome).

randomized control method was used to observe the clinical efficacy of the treatment of postmenopausal osteoporosis (kidney deficiency and blood stasis syndrome) with jiujian jiangu granules, combined with the gene expression of bone metabolism markers balp, pinp, tracp and s-ctx, and rank, rankl and opg detection, compared with the control group of ossification trihydrate capsules, to explore the mechanism of the treatment of postmenopausal osteoporosis by the continued xulin jiangu granules, and lay the foundation for the development of new drugs.

Eligibility criteria:
inclusion criteria: * at least 2 years prior and met the diagnostic criteria for osteoporosis according to the "clinical practice guidelines of traditional medicine for primary osteoporosis * met the cm diagnostic criteria according to "syndrome differentiation in modern research of traditional chinese medicine exclusion criteria: * patients who did not meet the diagnostic criteria for osteoporosis or cm standards * patients with rheumatoid arthritis, diabetes, secondary osteoporosis due to hyperthyroidism, and severe cardiovascular or cerebrovascular diseases * patients with abnormal liver and/or shen function test results * patients with osteoporosis who had received treatment with cm within the last month, hormone replacement therapy and calcitonin within the past three months, or bisphosphonates for 15 consecutive days within the past 6 months.

Keywords: osteoporosis kidney deficiency and blood stasis syndrome xuling jiangu granules
risk of acute kidney injury among patients with type 2 diabetes exposed to oral antidiabetic treatments

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to compare the incidence of hospitalization for acute kidney injury among patients with type 2 diabetes who are new initiators of saxagliptin and those who are new initiators of other oral antidiabetic drugs in classes other than dipeptidyl peptidase iv (dpp4) inhibitors.

prospectively designed retrospective database study. this study will be conducted using administrative claims data and electronic medical records that are collected as part of routine clinical practice. this will be a prospectively-designed database cohort study comparing hospitalizations for acute kidney injury among new initiators of saxagliptin compared to those who are new initiators of oads in classes other than dpp4 inhibitors. the study time frame will be from 2009 through 2014.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * newly prescribed saxagliptin or an oad in a class other than dpp4 inhibitors * enrolled in the respective database for at least 180 days prior to the first prescription of new oad exclusion criteria: * patients identified with a diagnostic code for acute kidney injury within the 180-day baseline period * patients with dpp4 inhibitor exposure during the baseline period * patients currently using exenatide or insulin
ct carcinogenic risk in patients with appendicitis

Conditions: Computed Tomography; Carcinogenesis; Radiation Exposure; Appendicitis

Summary: the purpose of this study is to compare the incidence rate of leukemia between ct-exposed and ct-unexposed group in patients who underwent appendectomy in south korea.

south korea has a single-payer healthcare system, administered by national health insurance service (nhis). as healthcare providers in south korea need to claim reimbursement to nhis for the vast majority of diagnostic and therapeutic procedures, the nhis database enabled us to construct a large cohort who did or did not undergo ct for appendicitis. the purpose of this study is to compare the incidence rate of cancer between ct-exposed and ct-unexposed group in patients who underwent appendectomy in south korea.

Eligibility criteria:
inclusion criteria: * patients will be entered in the cohort on the date of appendectomy under the diagnosis of appendicitis exclusion criteria: * (a) patients who had a cancer diagnosis before the date of appendectomy, * (b) those who had prior experience of ct examination more than 7 days before appendectomy, * (c) those who had syndromes or diseases predisposing cancers, * (d) those whose diagnosis was changed to appendiceal cancer and * (e) those whose follow-up duration was shorter than a lag period.