improvement of nutrition status, digestive conditions, and upper respiratory infections by using oral nutritional supplementation on children in vietnam

Conditions: Wasting; Undernutrition; Malnourished; Malnutrition

Summary: evaluating the efficiency of using the nutrient production toward nutrition status (anthropometric index, the prevalence of wasting), digestive disorders, anorexia, and upper respiratory infections in children aged 24 - 71 months.

the research involves a randomized controlled clinical trial (rct), the plan is expected to conduct from 2022 to 2023 with over 600 children aged 24-71 months. the nutritional product produces a high amount of energy that provides over 468 kcal/100g; 12,5g/100g of protein; 12,5/100 of fat; 59,5g/100g of carbohydrate 1000ng/100g of igg (immunoglobulin g) colostrum; 15,3mg/100g of 2'fl hmo (health maintenance organization); 160mg/100g of mct(medium chain triglycerides) ; 3,7mg/100g of fos(fructo-oligosaccharide) /inulin; 810mg/100g of lysine; 525mg/100g of calcium; 55,6mg/100g of magnesium; 5,6mg/100g of iron; 3mg/100g of zinc; 35,7µg/100g of manganese; 8,1µg/100g of selenium; 1290iu/100g of vitamin a; 220 iu/100g of vitamin d3; 33,1µg/100g of vitamin k1; 510µg/100g of vitamin b1; 700µg/100g of vitamin b2; 360µg/100g of vitamin b6; 1,4µg/100g vitamin b12; 3120µg/100g of acid pantothenic; 62,7µg/100g of acid folic. 90 grams of the product which equals 2 packs (210ml x 2 per day) will supply about 33,0% - 43,6% of the required energy for children aged 2-5 years. other 25 micronutrients and minerals include some essential vitamins such as calcium 78,8 - 94,5 % rdas, iron 91-93% rdas(recommended daily allowances), vitamin a 86-103,2% rdas, zinc 56-66% rdas, vitamin d3 33% rdas, selenium 37-43% rdas, vitamin k1 43-50% rdas, folic acid 38-56% rdas. with other elements such as 2'fl hmo (15,3 mg), fos/inulin (3700 mg), choline ( 28 mg, taurin 15,5 mg) ,colostrum igg 24 1000mg. the study will be conducted at schools and homes: 600 children erratically divided into 2 groups, 1 group will use the product for 3 months (with the amount of use: twice per day, 45,0 grams each time). the product will be distributed to the students through the schools. monitoring will be performed carefully by the commune and district health department and the centers for disease control and prevention weekly. the study aims to evaluate the efficiency of nutritional products toward nutrition status ( anthropometric index, the prevalence of wasting), digestive disorders, anorexia, and upper respiratory infections in children aged 24-71 months.

Eligibility criteria:
inclusion criteria: * children between the age of 24 - 71 months old that currently study in 10 preschools in the area of 10 selected communes. * the family volunteered for the child to participate in the study * currently residing at 10 selected communes (over 1 year of residing) * z-score whz/baz \< - 0.5 exclusion criteria: * lactose intolerance * children with a history of allergies, congenital diseases * intellectual disability or are suffering from acute and chronic infectious diseases

Keywords: children oral nutrition supplementation anorexic anorexia nervosa digestive disorders upper respiratory infections nutrition status wasting