Kornimate/medical-research-clean huggingface dataset:
the pacing (guided vs unguided) strategies study

Conditions: Body Temperature Changes

Summary: the objectives of this study are to demonstrate that real time physiological status monitoring and the use of optimization techniques during exercise can have a positive impact on physiological status, and to collect metabolic flexibility profiles of young fit adults during rest and exercise.

this experiment aims to accomplish two goals: collect additional metabolic flexibility data with young fit adults in response to exercise; and demonstrate that automated pace guidance generated from real-time thermal-work strain monitoring and an optimized pacing policy will allow less stressful completion of a timed (60 minute) treadmill exercise of 5 miles. each participant will undergo two treatments of first unguided followed by guided exercise. the two exercise sessions will be conducted as part of a \~24 hour stay in an indirect calorimetry chamber.

Eligibility criteria:
inclusion criteria: * male and female * ages 18 to 29 at the beginning of the study * relatively fit can run 2 miles in under 16 minutes exclusion criteria: * history of skin sensitivity to nickel * hypertension * alcoholism * diabetes * pregnant * age \>29 * cannot run 2 miles in less than 16 minutes * no regular weekly exercise * difficulty swallowing food or large pills * diverticulitis * inflammatory bowel disease * peptic ulcer disease * crohn's disease * ulcerative colitis * previous gastrointestinal surgery * possible nuclear magnetic resonance scan * women who have given birth during the previous 12 months * pregnant women or women who plan to become pregnant or become pregnant during the study * lactating women * history or presence of kidney disease, liver disease, certain cancers, gastrointestinal, pancreatic, other metabolic diseases, or malabsorption syndromes * history of bariatric or certain other surgeries related to weight control * smokers or other tobacco users (for at least 6 months prior to the start of the study) * history of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets) * volunteers who have lost 10% of body weight within the last 12 months or who plan to initiate a weight loss program during the next 10 months * unable or unwilling to give informed consent or communicate with study staff. * self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in alcoholics anonymous is not an exclusion) * other medical, psychiatric, or behavioral factors that in the judgment of the principal investigator may interfere with study participation or the ability to follow the intervention protocol * blood donation within the previous month
intersphincteric resection with or without intraoperative radiation in rectal cancer

Conditions: Rectal Cancer

Summary: the purpose of this study was to research on the safety and feasibility of isr combined with low energy x ray intra-operative radiotherapy for the patients with local advanced rectal cancer.

inter-sphincteric resection (isr) has become an increasingly popular optional surgical tool for the treatment of very low rectal cancer. nowadays, preoperative criteria for lap isr were the patients whose diagnosed with clinical stages t1-2 and n0_1, which only a few patients with early stages can benefit from it. however, intra-operative radiotherapy with low energy x ray applied by intrabeam is becoming an accepted radiotherapy technique for treatment of cancers. the purpose of this study was to research on the safety and feasibility of isr combined with low energy x ray intra-operative radiotherapy for the patients with local advanced rectal cancer.

Eligibility criteria:
inclusion criteria: * those whom were preoperatively assessed to be in clinical staget3 or has lymphatic metastasis by mri or ultrasonic endoscopy; * the lower edge of the tumor is away from the anal edge by less than 5 cm, or away from the dentate line by less than 3cm; * in intra-operative separation, the lower edge of the tumor is below the plane of the levator ani muscle or the tumor is hard to separate; * those in t4 stage and could be radically resected by intra-operative surgeon assessment; * adequate preoperative sphincter function and continence; (vi)local spread restricted to the rectal wall or the ias. * absence of distant metastases. exclusion criteria: * clinical t4 tumors based on the union for international cancer control uicc tnm classification (7th edition): * infiltrating gross appearance of the tumors; * poorly differentiated adenocarcinoma by biopsy specimens; * a degree of preoperative incontinence.

Keywords: ultra-low rectal cancer intersphincteric resection iort
nutrition impact on immunotherapy of cancer

Conditions: Nutrition Disorders; Immunotherapy; Cancer; Survival, Prosthesis

Summary: this study investigates nutritional status and outcomes of immuntherapy in cancer patients.

studies have shown that more than half of the patients with cancer are also malnourished at diagnosis. this increases patients' risk of complications associated with the treatment as well as the abandonment of care, as well as decrease the level of survival rates.

Eligibility criteria:
inclusion criteria: * diagnosis of cancer, malnutrition age \>18 years performance status ecog of 0 or 2. life expectancy ≥ 6 months. at least one lesion measurable as defined by standard imaging criteria for the patient's tumor type (recist v1.1) patients must have normal organ and bone marrow function measured within 28 days prior to administration of study treatment postmenopausal or evidence of non-childbearing status for women of childbearing potential patient is willing and able to comply with the protocol for the duration of the study. for all oral medications patients must be able to comfortably swallow capsules; exclusion criteria: * patients unable to swallow orally administered medication and patients with impairment of gastrointestinal (gi) function or gi disease that may significantly alter drug absorption of oral drugs history of allogenic organ, bone marrow or double umbilical cord blood transplantation. active or prior documented autoimmune or inflammatory disorders uncontrolled intercurrent illness or patient considered a poor medical risk due to a serious, uncontrolled medical disorder, including but not limited to, ongoing or active infection, symptomatic congestive heart failure currently taking medications with known risk of prolonging the qt interval or inducing torsades de pointes.
prevalence of erupted supernumerary teeth among a group of egyptian children aged from six to fifteen years old

Conditions: Supernumerary Teeth

Summary: the purpose of this study is to assess the prevalence of erupted supernumerary teeth among a group of egyptian children aged from 6-15 years old attending the outpatients' clinic of pediatric dentistry and dental public health department, faculty of dentistry, cairo university.

* clinical examination will be done for participants fulfilling the inclusion criteria after obtaining an informed consent from parents for acceptance of participation in the study after explaining the purpose of the study and the measures that will be held to the child. * a custom made examination chart (appendix 1) will be filled out, during face to face interview with the child and/or his parents, including: date, name, age, gender, address, medical history and previous dental treatment followed by clinical examination to detect the presence of supernumerary teeth. * the presence of supernumerary teeth and its type and location will be recorded in the examination chart. * each child with supernumerary teeth will be given a letter, translated into arabic, outlining his dental status to inform the parents about the condition and the need for treatment examination chart (appendix 1 ): date :................................................................... personal information: name............................................. age.......................................... gender :.......................................... address : ................................ phone number : .................................................. medical history: ......................................................... .................................................................................. previous dental history: ........................................... ...................................................................................... clinical examination : supernumerary teeth: presence / absence location : ........................................... type :..................................................

Eligibility criteria:
inclusion criteria: * positive patient and parent acceptance for participation in the study. * patients who are medically free from any systemic disease. * children aged from 6 to 15 years old. * both sexes will be included. exclusion criteria: * uncooperative children. * handicapped children. * children who refuse to participate in the study.

Keywords: supernumerary tooth hyperdontia mesiodens paramolar
single site, masked, randomized, controlled study to assess efficacy of osurdex as adjunct to avastin compared with avastin alone in the treatment of patients with macular edema due to central or branch retinal vein occlusion

Conditions: Retinal Vein Occlusions

Summary: comparative study to see if treating with osurdex in addition to avastin in patients with retinal vein occlusions helps increased visual acuity outcomes


Eligibility criteria:
inclusion criteria: * male or female age 18 years or older * branch retinal vein occlusion or central retinal vein occlusion of less than one year duration * best correct visual acuity of greater than 24 and less than 80 * presence of macular edema defined as oct central subfield thickness of \>250 exclusion criteria: * intravitreal anti-vegf treatment in study eye within six weeks of baseline * intravitreal steroid treatment in the study eye within eight weeks of baseline visit * prp in the study eye within 4 month of baseline visit * active iris neovascularization in study eye * uncontrolled systemic disease * known history of iop elevation in response to corticosteroid treatment that is not controlled on 2 glaucoma medications
neurobiological mechanisms of chess as an add-on treatment against sud

Conditions: Substance Use Disorders

Summary: neurobiological and neuropsychological approaches to investigate the potential mechanism of action of chess as an add-on therapy (chess based - cognitive remediation treatment, cb-crt) to reduce cognitive deficits in individuals with alcohol use disorder (aud) or tobacco use disorder (tud).

the study aims to investigate the potential mechanism of action of chess as a "chess based - cognitive remediation treatment, cb-crt" to reduce cognitive deficits in individuals with substance use disorder (sud) seeking treatment using neurobiological and neuropsychological approaches. furthermore, it will be assessed whether this chess intervention has a generalized positive effect on short-term abstinence. interestingly, the functional domains and associated underlying neuronal networks observed to be affected in individuals with sud overlap significantly with those that could be strengthened by chess-based cognitive training or formal chess. specifically, strengthening of cortical control regions (dorsolateral prefrontal cortex, dlpfc) and brain areas relevant for decision-making (orbitofrontal cortex, ofc) could prevent future relapse. therefore, chess as an add-on therapy to complement other standard treatments of sud could lead to improved therapeutic outcomes.

Eligibility criteria:
inclusion criteria: * severe alcohol (aud) or tabacco use disorder (sud) according to dsm-5 * abstinence from alcohol for at least 72 hours (aud) * sufficient ability to communicate with investigators and answer questions in both written and verbal format * ability to provide fully informed consent and to use self-rating scales * main diagnosis aud: inpatient or outpatient treatment in our clinic * main diagnosis tud: participation in 6 weeks smoking cessation treatment * normal or corrected to normal vision * signed consents for data security exclusion criteria: * severe internal, neurological, and/or psychiatric comorbidities; other axis i mental disorders other than tud according to icd-10 and dsm 5 (except for other substance use disorders - if aud or tud is still the main diagnosis -, adhd, remitted depression, mild or moderate depression, adjustment disorder, generalized anxiety disorder, phobias, panic disorder or other mild or moderate personality disorders) in the last 12 months * severe withdrawal symptoms (ciwa-ar \> 7; sullivan et al. 1989) * alcohol intoxication (\>0‰) * history of brain injury * severe cognitive impairments * common exclusion criteria for mri (e.g. metal, claustrophobia, pregnancy) * suicidality or endangerment of others * positive covid-19 screening

Keywords: alcohol dependence alcoholism craving cognitive change cognitive remediation chess based cognitive training working memory decision making executive control chess fmri nicotine use disorder tobacco use disorder
intermittent hypoxia in persons with multiple sclerosis

Conditions: Multiple Sclerosis; Multiple Sclerosis-Relapsing-Remitting; Multiple Sclerosis, Secondary Progressive

Summary: this study aims to understand the mechanisms of a novel intervention involving breathing short durations of low levels of oxygen for persons with multiple sclerosis (ms). this intervention with low levels of oxygen is called acute intermittent hypoxia (aih), the levels of oxygen experienced are similar to breathing the air on a tall mountain, for less than 1 minute at a time. previous studies have shown that aih is a safe and effective way to increase strength in persons with ms. here the investigators aim to look at brain activation and ankle strength before and after aih to gain a better understanding of how the aih may improve strength in those persons with ms.

recent research has shown that aih, characterized by brief episodes of reduced oxygen levels in the inspired air, has the potential to induce neural adaptations. these adaptations are suspected to influence several aspects of neuroplasticity, including the modulation of neurotransmitters and neurotrophic factors. persons with ms typically exhibit greater cortical activation to achieve a given motor task compared to healthy controls, suggesting compensatory activations in motor cortices and the recruitment of additional non-motor regions for successful motor control. therefore, interventions that promote adaptive neuroplasticity in motor control systems may induce a reduction in fmri activation during motor tasks as well as an increase in functional connectivity between somatomotor cortices. this study will explore potential mechanisms of this intervention in ms using motor task performance and advanced neuroimaging techniques.

Eligibility criteria:
inclusion criteria: * diagnoses of relapsing form of ms (including relapsing-remitting ms and secondary-progressive ms) * expanded disability status scale (edss) score of at least 3 and no more than 6.5 * motor functional system scale (fss) between 2-4 * relapse free for at least 1 year * age ≥ 18 years and ≤ 75 years * safe to be scanned based on mri questionnaire * participants using dalfampridine will be eligible if taking the same daily dose for at least 2 months prior to screening exclusion criteria: * active contrast-enhancing ms lesions, or diffusion positive lesions suggestive of acute cerebrovascular disease on baseline mri scan * uncontrolled hypertension (systolic between 85 and 140, diastolic between 90 and 55) * history of epilepsy * chronic obstructive pulmonary disease * uncontrolled sleep apnea * pregnancy

Keywords: multiple sclerosis aih hypoxia
therapeutic recommendations for the treatment of children with a retinoblastoma

Conditions: Retinoblastoma

Summary: as the survival of children with retinoblastoma in high income countries is higher than 95% including the bilateral forms this study hopes to improve the outcome in low income countries in africa by improving early diagnosis and early implementation of this protocol of therapeutic recommendations for treatment.

in this study we will try to improve the outcome for children with stage ii disease. it is hoped that we will be able to show that with early intervention correct early diagnosis the survival of these children is greatly improved. the collection of data in this observational study will allow us to show this improvement, by analysis of stage, treatment and outcome.

Eligibility criteria:
inclusion criteria: * unilateral intraocular retinoblastoma (rb) * unilateral extraocular intraorbital (rb) * bilateral intraocular (rb) * bilateral intraocular (rb) on one side and extraocular but intraorbital on the other side. exclusion criteria: * externalized tumor mass * massive extension to optic nerve up to optical channeltumor * intracranial extension leptomeninges * cerebral parenchyma * extension to regional lymph nodes and/or remote metastases. * cerebrospinal fluid involvement. * trilateral rb * incapacity to followed the whole treatement.
study of the safety of mdx-1342 in combination with methotrexate in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to determine if mdx-1342 given in combination with methotrexate is a safe treatment for patients with active rheumatoid arthritis. in addition, changes in the severity patients' arthritis will also be analysed.


Eligibility criteria:
inclusion criteria: * must have met acr criteria for the diagnosis of rheumatoid arthritis (ra) * must have active ra * must be treated with methotrexate (mtx) (10 to 25 mg weekly) for at least 3 months and have received a stable dose for at least 28 days prior to the anticipated study drug administration date. * all other dmards or biologics must be discontinued at least 28 days prior to study drug administration and: 1) leflunomide, which must be discontinued at least 60 days before study drug administration, 2) infliximab, adalimumab, and abatacept must be discontinued at least 56 days prior to study drug administration exclusion criteria: * both rheumatoid factor and anti-ccp negative * prior treatment with any b-cell depleting therapy * any other mab or ig-based fusion proteins 56 days or less prior to visit * history of or current inflammatory joint disease other than ra * neuropathies or neurovasculopathies that might interfere with pain evaluation * complications of ra or other disease * any other autoimmune disease other than ra * acute or chronic infection * clinically significant disease requiring

Keywords: rheumatoid arthritis ra joint inflammation autoimmune medarex rheumatology
korean heart failure registry iii

Conditions: Acute Heart Failure

Summary: korhf iii is a multi-center, nationwide, prospective registry of the korean society of heart failure, which enrolls patients with acute heart failure in korea. the aim of this registry is to analyze the etiology, treatment, treatment, and prognosis to develop strategies for managing acute heart failure.


Eligibility criteria:
all consecutive hospitalized adult heart failure patients who fulfill one of 1-3 and 4 inclusion criteria: 1. symptoms of heart failure 2. signs of heart failure 3. lung congestion in chest-x-ray 4. objective finding of structural and/or functional disorder of the heart or elevated natriuretic peptide levels exclusion criteria: 1. patients younger than 18 years old 2. patients who do no consent
compartment syndrome validation of non invasive assessment of tissue pressure

Conditions: Compartment Syndrome

Summary: chronic compartment syndrome (ccs) is a pathology that affects more specifically subjects exposed to repeated movements, particularly in a professional life or sports. the diagnosis is difficult and often delayed. currently, the reference technique is invasive. it consists of measuring by a intramuscular puncture (imp) pressure in the offending compartment early after effort (usually between 1 and 5 minutes post-exercise). a value greater than or equal to 30 mmhg in the first 5 minutes is used as a diagnostic criterion for ccs. other less invasive techniques (scintigraphy) exist but are subject to certain discordances of interpretation. the advent of new assessment tools, like the myotonpro, pave the way for a non-invasive diagnostic approach.

patients referred for suspected chronic compartment syndrome causing will be included. after signing the consent, the subject will have a clinical and paraclinical examination. age, sex, height, weight, side of clinical symptomatology will be collected. medical history current treatments will also be noted. once the consent is collected, the patient performs, according to the data of the literature and service habits a stress test aimed at triggering the painful symptomatology associated with post-exercise imp and myotonpro measurements as the same time.

Eligibility criteria:
inclusion criteria: * affiliation to the french national healthcare system * french speaking patients * referred for investigation of compartment syndrome causing exclusion criteria: * pregnancy * inability to understand the study goal * patients protected by decision of law * extended dermatosis * coagulation disorder

Keywords: compartment syndrome intramuscular punction versus non invasive assessment
study of obeldesivir as postexposure prophylaxis for marburg virus disease

Conditions: Postexposure Prophylaxis Marburg Virus Disease

Summary: the goal of this clinical study is to learn more about the study drug, obeldesivir (odv), and how safe and effective it is preventing marburg virus disease (mvd) in participants with known or suspected exposure to marburg virus (marv). the primary objective is to evaluate the safety and tolerability of odv for marv postexposure prophylaxis (pep).


Eligibility criteria:
key inclusion criteria: * able to understand and give written informed consent and comply with treatment and follow up. * individuals who are of childbearing potential and engage in heterosexual intercourse must agree to use protocol-specified method(s) of contraception * known or suspected high-risk exposure to marv within 21 days of day 1. high-risk exposure may include the following: 1. direct contact with bodily fluids from a confirmed mvd case. 2. needle stick injury with a needle potentially contaminated with marv. 3. prolonged exposure to an individual with marv infection or mvd without (adequate) personal protective equipment. key exclusion criteria: * individuals with plans to breastfeed during the study period and 21 days following the last dose of study intervention. world health organization guidance on breastfeeding should be followed. * known hypersensitivity to the study intervention, its metabolites, or formulation excipient. * known marv reverse transcriptase-polymerase chain reaction (rt-pcr) positivity or symptomatic mvd as attributed by the investigator. * known moderate or severe renal impairment or known estimated glomerular filtration rate (egfr) \< 60 ml/min/1.73 m\^2. * decompensated cirrhosis (child-pugh class c), acute liver injury/failure (eg, new onset \[\< 2 weeks\] of easy bruising, jaundice, ascites, hepatic encephalopathy, asterixis), and/or known alanine aminotransferase ≥5 × upper limit of normal. note: other protocol defined inclusion/exclusion criteria may apply.