Kornimate/medical-research-clean huggingface dataset:
osseous setting improvement with co-implantation of osseous matrix and mesenchymal progenitors cells from autologous bone marrow

Conditions: Tibia or Femur Pseudo-arthrosis

Summary: sometime osseous reconstruction needs allogeneic bone, in this study we use ostéopure™ from ostéobanque d'auvergne, which is a osseous matrix. however ostéopure™ integration lasts a long time. to optimize this integration we purpose to associate mesenchymal progenitors cells from autologous bone marrow.

all patients will be treated for tibia or femur pseudo-arthrosis. at the beginning of chirurgical intervention, autologous bone marrow will be sampling and will be concentrated during this one. meanwhile osseous matrix (ostéopure™ ) will be incubated in autologous blood serum and finally implanted in the fracture site. and after (at the end of chirurgical intervention), concentrate autologous bone marrow will be injected in the same place.

Eligibility criteria:
inclusion criteria: * tibia or femur pseudo-arthrosis, * patient who needs bone graft exclusion criteria: * - contra indications for chirurgical intervention or bone graft

Keywords: pseudo-arthrosis, osseous matrix, cell therapy
efficacy and safety of triple therapy in patients with anti-mda5 antibody-positive dermatomyositis

Conditions: Dermatomyositis, Adult Type; Interstitial Lung Disease

Summary: we conduct this study to investigate the efficacy of triple therapy (high-dose glucocorticoids + cyclophosphamide + calcineurin inhibitor) compared with dual-therapy regimens (high-dose glucocorticoids + cyclophosphamide/calcineurin inhibitor) and whether it reduces the risk of poor pulmonary prognosis in patients with moderate to high risk anti-mda5+ dm.


Eligibility criteria:
inclusion criteria: * adult patients meet the diagnostic criteria for dermatomyositis of bohan and peter * anti-mda5 antibody-positive exclusion criteria: * complicated with other connective tissue diseases * complicated with cardiovascular and respiratory disease caused by other reasons * interstitial lung disease caused by environment and drugs * patients with key research missing data or without informed consent
influence of surface characteristics of gait training on gait kinematics and walking capacity in children with diplegic cp

Conditions: Diplegic Cerebral Palsy

Summary: using challenging surfaces of gait training, which require constant adjustments of the body's movement patterns to maintain stability and provide different sensory and proprioceptive inputs to mimic real life situation is appropriate for children with cp. so, the purpose of the current study is to investigate the influence of surface characteristics of gait training on gait kinematics and walking capacity in children with diplegic cp.

the purpose of the study is to determine the influence of surface characteristics (different surfaces materials and textures) of gait training on kinematics gait parameters (step length, step width, double support time and cadence) and the functional walking capacity in children with diplegic cp.

Eligibility criteria:
inclusion criteria: 1. their ages will range from 6 to 8 years old. 2. the degree of spasticity will range from grade 1 or 1+ according to modified ashworth scale. 3. they will be at level ii on gmfcs . 4. they will be able to follow verbal command or instructions. exclusion criteria: * 1. fixed deformities of lower limbs. 2. sever visual or auditory problems. 3. history of surgical interference in lower limbs less than one year. 4. botulinum toxin injections to the lower limb during the previous 4 months.

Keywords: cp , diplegia
efficacy of dexmedetomidine in preventing contrast induced nephropathy

Conditions: Radiographic Contrast Agent Nephropathy

Summary: the aim of this study was to evaluate the effects of dexmedetomidine on renal function, hormonal and hemodynamic parameters in contrast media induced diabetic patients.

contrast nephropathy may occur after using intravenous contrast media and may result in acute renal failure. contrast nephropathy usually reversible but in some cases it can be permanent. this situation increase the time of hospitalization and mortality of the patients. although the only proved prevention from contrast nephropathy method is hydration, infusion of dexmedetomidine may keep the renal functions.

Eligibility criteria:
inclusion criteria: * scheduled for percutaneous coronary angiography * \> 18 yo * diabetic patients * creatinin value \< 3 mg/dl exclusion criteria: * contrast agent hypersensitivity * pregnant patients * creatinin value ≥3mg/dl * patients have acute renal failure

Keywords: contrast induced nephropathy diabetes mellitus dexmedetomidine
diagnostic value of endoscopic ultrasound elastography and contrast enhanced endoscopic ultrasound for differential diagnosis of gallbladder polyp

Conditions: Gallbladder Polyps or Masses Greater Than 8-10 mm in Size

Summary: gallbladder polyps are often detected incidentally by ultrasonography. the most of gallbladder polyps are non-neoplastic such as cholesterol polyps and do not need further treatments. however, neoplastic polyps, which need additional treatments to prevent malignancy, show the same appearance on ultrasound. clinically, the differential diagnosis between cholesterol polyps and adenomatous polyps is very important for patient follow-up and treatment. however, differential diagnosis between these two conditions is difficult using conventional trans-abdominal ultrasound. endoscopic ultrasound (eus) is less affected and disturbed by subcutaneous fat or intraabdominal air, so a clearer image of pancreatobiliary system can be obtained. in addition, eus elastography and contrast enhanced eus are recently introduced. eus elastography enables practitioners to evaluate the stiffness of a target lesion and compare it with surrounding tissues (strain ratio). also, contrast enhanced eus is used widely with additional information such as presence of vessels and enhancement pattern of soft tissues. several studies have been published that eus elastography can help in the differential diagnosis of pancreatic solid lesions. although studies have been conducted to confirm the usefulness of transabdomnial ultrasound with elastography or contrast enhancement at differentiating gallbladder polyps, no prospective studies have been conducted to evaluate the usefulness of eus elastography or contrast enhanced eus for gallbladder polyp. therefore, with this prospective study, we would like to evaluate the diagnostic value of eus elastography and contrast enhanced eus for differential diagnosis of gallbladder polyps.


Eligibility criteria:
1. inclusion criteria: 1. gallbladder polyp of 8-10mm or more in size confirmed by imaging tests 2. must be 19 years old or older 3. with voluntary agreement to participate in the study after be informed about the necessity of eus due to the clinical necessity 2. exclusion criteria: 1. unable to confirm histological diagnosis (ex. patients did not underwent cholecystectomy) 2. younger than 18 year-old 3. without agreement with this study or informed consent

Keywords: gallbladder polyp endoscopic ultrasound elastography contrast enhanced endoscopic ultrasound
a comparison of beclomethasone aqueous spray and aerosol delivery systems in nasal polyps

Conditions: Nasal Polyps

Summary: the purpose of this study is to determine if intranasal beclomethasone delivered by aerosol or spray is more effective in treatment of nasal polyps.

aqueous and aerosol delivery of intranasal corticosteroids has never been directly compared previously in patients with nasal polyps and it is unknown whether one is superior. this objective of this study is to compare the efficacy of intranasal beclomethasone by two different delivery systems, aerosol and aqueous spray in patients with nasal polyps. primary endpoint is the difference in the overall quality of life as measured by the rhinitis quality of life questionnaire. the secondary endpoint is the change in nasal airflow resistance as measured by rhinomanometry.

Eligibility criteria:
inclusion criteria: * 18 years old * new diagnosis of nasal polyps confirmed by two physicians exclusion criteria: * intranasal corticosteroid use within 4 weeks * oral corticosteroids use within 4 weeks * oral corticosteroid inhalation (ie for treatment of asthma or copd) of budesonide \>400ug daily, fluticasone \>250ug daily, beclomethasone \>400ug daily * contraindication to intranasal corticosteroid * inability to give informed consent * participation in another clinical trial * pregnancy (or not using effective method of contraception) or lactation * cystic fibrosis

Keywords: administration, intranasal aerosol beclomethasone qvar corticosteroids nasal polyps rhinomanometry rhinitis quality of life questionnaire quality of life
investigating program of food preparation on diet improvement for patients with stroke

Conditions: Stroke; Dysphagia, Late Effect of Stroke

Summary: this is a randomized controlled behavioral intervention trial to assess the efficacy of investigating program of food preparation on diet improve patients with stroke.

this is a randomized controlled behavioral intervention trial to assess the efficacy of investigating program of food preparation on diet improve patients with stroke. subjects will be randomized to intervention group and control group.the primary outcome included seven measures, functional oral intake scale, mini nutritional assessment, council on nutrition appetite questionnaire, dietary well-being scale, swallowing quality of life questionnaire, who quality of life-bref and eating assessment tool-10.

Eligibility criteria:
inclusion criteria: * diagnosis is stroke * eat-10 ≥ 3 * aged \> 20 years * capability of following instructions * willing to participants to the study exclusion criteria: * non-stroke neurological diseases ( ex: traumatic brain injury, brain tumor, neurodegenerative disease and parkinson's disease ) * dysphagia by neck injury or surgery * during the study, he/she was hospitalized again due to disease.

Keywords: food preparation dietary well-being quality of life dysphagia stroke
nice human immunodeficiency virus (hiv) cohort

Conditions: Human Immunodeficiency Virus

Summary: historically, the database on the hiv was organized within the framework of the medico-economic file of the human immunodeficiency (dmi-2), introduced jointly by the direction of hospitals (mission aids) and the inserm at the end of the 80s. today this database is fed via the computerized medical record nadis. most part of the research works on the theme of the hiv take support on this database (dad, euroaids, neuradapt).


Eligibility criteria:
inclusion criteria: * enrol consecutive patients with a scheduled visit in the outpatient clinic (regardless of cd4 cell count and art status). exclusion criteria: -
high dose vitamin c in the critically ill patient

Conditions: Shock

Summary: the purpose of this study is to determine the effectiveness of high doses of vitamin c in critically ill patients.

it has been shown that the stress that occurs during trauma, infection and/or shock depletes many of the body's resources such as vitamin c (ascorbic acid) which may contribute to further complications. the purpose of this study is to determine the effectiveness of high doses of vitamin c in critically ill patients.

Eligibility criteria:
inclusion criteria: * activation of the mass transfusion protocol following surgery or trauma. * diagnosis of septic shock. septic shock will be defined as sepsis induced hypotension (i.e. systolic blood pressure \ 40mmhg in the presence of infection) that does not respond to a 2 liter fluid bolus. exclusion criteria: * age less than 18 years. * pregnant women. * creatinine of greater than 2.2 g/dl at time of enrollment, history of chronic kidney or end stage renal disease, rise in creatinine \> 1 g/dl within 24 hours prior to enrollment. * brain death diagnosed within 4 hours of presentation to the trauma bay or intensive care unit * patients with history of hemolytic blood disease, e.g. glucose-6-phosphate dehydrogenase deficiency, sickle cell disease and thalassemia. * patients in isolated cardiogenic shock. * history of liver cirrhosis * transplant patients (liver, kidney, heart)

Keywords: hypovolemic or septic
pain in sickle cell epidemiologic study

Conditions: Blood Disease; Anemia, Sickle Cell

Summary: to measure the variability in pain and response to pain in sickle cell disease, and to build multivariate models to explain both patients' pain and their response to pain, especially, utilization of health care.

background: pain in sickle cell disease is poorly recognized, measured, and treated. although painful episodes are the most common reason sickle cell patients seek care, studies have seldom directly measured pain in detail. in studies to date, biological and demographic variables alone only partly explain the observed variance in painful episode frequency. further, little is known about differences in pain responses including home management versus health care utilization. design narrative: this cohort study is measuring the variability in pain and response to pain in sickle cell disease, and building multivariate models to explain both patients' pain and their response to pain, especially, utilization of health care. the models' outcome variables include mean pain, painful episodes, and various types of utilization episodes, including non-narcotic analgesic use, narcotic use, office visits, emergency department (ed visits, and hospitalization. an additional outcome is the percentage of each patient's painful episodes that result in various types of utilization. outcomes will be operationalized using daily pain diaries collected over six months. reflecting on the prior 24 hours, patients will recall on an ordinal (0-9) scale maximum pain, distress, and disability, judge whether they were in a "crisis," and note pain locations and their various types of utilization. daily pain intensity ratings will be transformed into pain episode counts using a formulaic threshold for a painful episode. the formula calculates each patient's threshold individually, based on his/her pain ratings. the models will measure the effect of several classes of explanatory variables (demographic, disease-related, psycho social, and readiness to utilize care), operationalized using primary data and validated instruments. patients will be recruited from the central and tidewater regions of virginia, will undergo an initial survey battery, chart review, and a brief final survey, venipuncture and urine sampling, and complete pain diaries daily for six months. this study will advance knowledge of the etiology and influences on pain and pain response in sickle cell disease. by revealing potentially mutable explanatory variables, the study's results will suggest targets of biobehavioral treatment interventions.

Eligibility criteria:
no eligibility criteria
dietary therapy in children with refractory epilepsy

Conditions: Epilepsy

Summary: in children aged 1yr -18 years with refractory epilepsy modified atkins diet as add on to ongoing aed therapy would not be inferior compared to ketogenic diet \*\* in terms of seizure reduction from baseline seizure frequency at 6 months

primary objective: to compare the efficacy of modified atkins diet compared to ketogenic diet \* in children aged 1 year to 18 years of age with refractory epilepsy on anti epileptic drugs at 6 months of diet intake in terms of percentage of seizure reduction from base line. secondary objective: proportion of patients who achieve \> 50% seizure reduction from baseline after 6 months in both groups to evaluate the nature of adverse events in both the groups

Eligibility criteria:
inclusion criteria: * children aged 1-18 years with refractory epilepsy\* * willing to come for regular follow up * no motivational or psychosocial issues in the family which would preclude compliance with the diet exclusion criteria * surgically remediable cause for refractory epilepsy * suspected mitochondrial disorder or diagnosed with a disorder in which high fat diet is contraindicated * previously received ketogenic diet or modified atkins diet * chronic systemic disease like chronic kidney disease, chronic liver disease, heart disease (congenital and acquired) and chronic respiratory illness
ultrasound guided bilateral erector spinae plane block in retropubic radical prostatectomy

Conditions: Postoperative Pain

Summary: this study will define the postoperative analgesic effect of esp block via amount of patient-controlled analgesia (pca) and postoperative analgesic consumption (such as routinely and rescue analgesics) and compare the control group patients with retropubic radical prostatectomy .

open retropubic prostatectomy is a surgical method that is applied in cases of benign prostatic hypertrophy and prostate cancer which is not suitable for surgical treatment with closed method. this method is commonly used among urological procedures which are open surgical procedures. patients after this procedure often complain of excessive pain. non-steroidal anti-inflammatory agents and opioids are used for postoperative analgesia. in addition, in the past decade, in the guideline of ultrasonography, peripheral block types have been described that demonstrate analgesic activity in open prostatectomies as well as many operations on the development of regional anesthesia and analgesia techniques. the ultrasonography guideline reported that the transverse abdominal plane (tap) block provides effective analgesia in these cases. the esp block is a new block for the treatment of thoracic neuropathic pain. in the following process; esp block thoracic and breast surgery, bariatric surgery, and upper abdominal surgeons have also been reported to provide effective postoperative analgesia. the standard practice for post-operative pain management for retropubic radical prostatectomy in maltepe university hospital consists of routine intravenous analgesic and rescue analgesics and in combination with patient-controlled analgesia (pca). the application of erector spinae plane (esp) block technique under ultrasonography guideline under sedoanalgesia in patients who will undergo retropubic prostatectomy with open method should determine the effect on the patient's pain level in the first 24 hours after operation.

Eligibility criteria:
inclusion criteria: elective retropubic radikal prostatectomy, asa status 1-2 exclusion criteria: * patient refusal * contraindications to regional anesthesia * known allergy to local anesthetics * bleeding diathesis * use of any anti-coagulants * inability to provide informed consent * severe kidney or liver disease * inability to operate pca system * patient with psychiatric disorders

Keywords: ultrasound guided erector spinae plane block postoperative pain retropubic radical prostatectomy
a study of staccato loxapine (adasuve®) for inhalation

Conditions: Psychomotor Agitation; Schizophrenia; Bipolar Disorder

Summary: phase 3 safety and efficacy study of staccato loxapine in the treatment of acute agitation in schizophrenic or bipolar disorder patients.

this is a multi-center, randomized, double-blind, placebo-controlled, parallel group, efficacy and safety study of staccato loxapine or placebo in treating acute agitation in patients with schizophrenia or bipolar disorder (manic or mixed episodes) as defined by dsm-v criteria.patients may receive up to 3 doses of study drug in a 24-hour period, depending on their clinical status. the primary endpoint is the change from baseline in the panss (positive and negative symptom scale) excited component (also known as pec) score, performed at 2 hours after the first dose.

Eligibility criteria:
inclusion criteria: * 1. male and female patients between the ages of 18 to 65 years, inclusive. * 2. patients who met diagnostic and statistical manual of mental disorders (dsm-v) criteria for schizophrenia or bipolar disorder. * 3. patients are judged to be clinical mild to moderate agitation at baseline with a total value of ≥ 14, and have a score ≥4 on at least 1 of 5 items on the panss-ec scale, and with a value of ≥3 on cgi-s scale. * 4. patients are judged to be cooperative by the investigator. * 5. written informed consent from patients (and/or legally acceptable representative, legally acceptable representative preferred) is obtained. exclusion criteria: * 1. patients with agitation caused primarily by delirium, dpilepsy, developmental retardation, acute alcohol or psychoactive drugs intoxication/withdrawal symptoms (as per investigator's judgment). * 2. patients judged to be at serious risk for suicide as per the investigator's judgement. * 3. patients with a history of allergy or intolerance to loxapine or amoxapine. * 4. female patients of childbearing potential who have a positive urine pregnancy test at screening or breastfeeding. * 5. patients with acute respiratory signs/symptoms (e.g., wheezing) or with active airways disease (such as patients with asthma or chronic obstructive pulmonary disease). * 6. patients who are considered by the investigator, for any reason, to be unsuitable candidates for receiving inhaled loxapine, or are likely to be unable to use the inhalation device.

Keywords: schizophrenia bipolar disorder agitation inhaled loxapine adasuve
intestinal perforation in patients receiving an orthtopic liver transplantation in the montpellier university hospital

Conditions: Liver Transplantation; Intestinal Perforation; Digestive System Fistula; Intestinal Fistula

Summary: liver transplantation enhances the prognosis of patients with cirrhoses or hepatocellular carcinoma. however some patients develop intestinal perforations for which the prognosis is poor. the aim of the study is to evaluate the risk factors of intestinal perforations using a retrospective study scheme.

liver transplantation enhances the prognosis of patients with cirrhoses or hepatocellular carcinoma. however some patients develop intestinal perforations for which the prognosis is poor. the aim of the study is to evaluate the risk factors of intestinal perforations using a retrospective study scheme. previous studies have shown a possible implication of drugs or medical history or intraoperative complications. the investigators aim to describe the other possible risk factors (such as portal vein clampage) and the type of surgery done after the diagnosis and its impact on survival as well.

Eligibility criteria:
inclusion criteria: * patients having received an orthotopic liver transplantation in the montpellier university hospital from 2014 to 2019 * for the group perforation: patients having during the follow-up a complication such as intestinal perforation. the complete list uses the icd-10 codes for intestinal perforation, esophageal perforation, duodenal perforation etc. exclusion criteria: * no exclusion criteria

Keywords: risk factors survival
effect of 1.5% potassium oxalate on the control of tooth sensitivity and color change after home bleaching

Conditions: Dentin Sensitivity

Summary: this double-blind randomized clinical trial evaluated the effect of 1.5% potassium oxalate on pain sensitivity control and color change after home tooth whitening. it also evaluated the influence of potassium oxalate on health-related quality of life (hrqol) and on the degree of patient satisfaction after bleaching treatment.


Eligibility criteria:
inclusion criteria: * individuals aged 18 to 29 years of both sexes with chroma greater than a2 in the upper incisors and canines, in the vita classical color scale; * absence of active caries lesions * patients who had never undergone bleaching therapy; * good oral hygiene and no hypersensitivity to tactile and evaporative stimuli through the visual analog pain scale; exclusion criteria: * patients undergoing fixed orthodontic treatment; * patients with darkened non-vital teeth and/or with extensive restorations in molars; * presence of cracks or fractures; * patients allergic to the product, with the presence of gastroesophageal disorders and with dentinal exposure in anterior and/or posterior teeth.