Kornimate/medical-research-clean huggingface dataset:
a comprehensive online program for cognitive enhancement, reassurance and training

Conditions: Cognition Disorders in Old Age; Lifestyle, Healthy; Diet, Healthy; Exercise

Summary: the concert study (a comprehensive online program for cognitive enhancement, reassurance and training) was designed to introduce a user-friendly platform to assess and train cognition among old adults. our main research questions are: i) is it possible to provide a user-friendly platform to perform multi-domain cognitive training for old adults? ii) are there any safety issues with these platforms? inclusion criteria include: i) aged ≥ 65 years; ii) owning a computer with access to the internet and basic knowledge to use it; iii) having sufficient english language skill; iv) normal baseline ad8 screening test; v) agree to join the study with their partners/ close family members. exclusion criteria include: i) history of dementia; ii) severe physical disability precluding to participate in meetings; those using wheelchairs can still join the study with some modification in the exercise program. study duration includes 24 weeks of intervention with lifestyle changes (online: nutrition consultation and teaching, exercise, dance, music therapy and cognitive enhancement). participants have options to continue the study for another 24 weeks. outcome will be assessed based on participants' adherence, satisfaction.

the concert study is designed to provide an online platform for the public to provide healthy lifestyle recommendations and assess cognition. 60 participants (30 cases and 30 study partners) will be invited to this project. at baseline, all cases will be assessed with regard to cognition (ad8 dementia screening interview), depression (geriatric depression scale) and gait (timed up and go). participants will be asked to check their blood pressure at baseline and then every 3 months according to the hypertension canada's 2020 guideline. all cases will be asked to participate in different educational classes, including nutrition consultation and teaching, exercise, dance (waltz), and music for 24 weeks. they will be also advised to accept the responsibility of a plant (pothos, spider plant, crocodile fern and aglaonema) at home. all meetings/ assessments are online. the investigators will assess adherence and satisfaction in all cases after 24 weeks. all cases will be invited to participate in another 24 weeks of intervention as an optional part of this study.

Eligibility criteria:
inclusion criteria: * aged ≥ 65 years; * owning a computer with access to the internet and basic knowledge to use it; * having sufficient english language skill; * normal baseline ad8 screening test; * agree to join the study with their partners/ close family members. age of family member or friend is not an exclusion criteria. exclusion criteria: * history of dementia; * severe physical disability precluding to participate in meetings; those using wheelchairs can still join the study with some modification in the exercise program; * active coronary heart disease or limitation for exercise based on their previous consults with their family physician/ cardiologists.
cognitive training and brain stimulation in patients with post-covid-19 cognitive impairment

Conditions: COVID-19; Post-COVID-19

Summary: the aim of the study is to investigate effects of brain stimulation-assisted cognitive training in patients with persistent subjective or objective cognitive impairment after polymerase chain reaction (pcr)-positive covid-19 disease.

long-term persistent symptoms occur in a substantial number of patients diagnosed with coronavirus 2019 disease (covid-19). first evidence suggests that long-term symptoms develop not only after severe courses of the disease, but also after less serious illness and include various symptoms such as fatigue and impaired memory, concentration or sleep. during recovery, these symptoms present a heavy burden for patients, who then often experience psychological distress and reduced quality of life. the goal of the present study is to assess the effects of cognitive training alone or in combination with tdcs on cognitive performance, quality of life and mental health in patients with subjective or objective cognitive impairments following post-covid disease. patients will either participate in a three-week cognitive training with concurrent online high-definition tdcs application or placebo ("sham") tdcs or participate in an evidence-based muscle relaxation training combined with placebo tdcs. we hypothesize that cognitive training with sham or active tdcs will result in more pronounced improvement on a transfer task compared to the control group. we also hypothesize that training combined with anodal tdcs will lead to significantly higher performance on a transfer task than training combined with sham tdcs. additionally, we will determine effects on specifically trained and other untrained cognitive functions immediately after the intervention as well as their maintenance one month later.

Eligibility criteria:
inclusion criteria: 1. history of covid-19 condition at least 4-6 weeks prior to study inclusion 2. self-reported concerns regarding cognitive functioning. 3. age: 18-60 years. exclusion criteria: 1. acute covid-19 illness. 2. history of dementia before covid-19. 3. other neurodegenerative neurological disorders; epilepsy or history of seizures. 4. severe and untreated medical conditions that preclude participation in the training, as determined by responsible physician. 5. history of severe alcoholism or use of drugs. 6. severe psychiatric disorders such as severe depression (if not in remission) or psychosis. 7. contraindication to tdcs application (antal et al. 2017).
ibsr meditation technique for teachers' burnout

Conditions: Burnout, Professional

Summary: the purpose of this study is to investigate the effect of inquiry based stress reduction (ibsr) meditation technique on levels of burnout and wellbeing among teachers.

teachers' burnout is a well-known phenomenon with personal and professional implications. the current study investigates the effect of inquiry based stress reduction (ibsr) technique on burnout and well-being among teachers.

Eligibility criteria:
inclusion criteria: * all the teachers working in 'begin' high-school, rosh hayin, israel * agreed to sign an informed consent form exclusion criteria: * teachers with previous experience with ibsr technique

Keywords: burnout teachers meditation ibsr "the work" byron katie
zirconia-based primary anterior crowns with retention grooves versus without retention grooves

Conditions: Dental Caries; Tooth Decay

Summary: the purpose of this research study is to test the effectiveness of two different crowns/caps on teeth for restoration of primary anterior teeth. the two different materials of crowns are esthetic crowns with retentive grooves and without retentive crowns. these crowns are placed on the teeth to restore function, esthetics and prevent further caries and infection.

there are many treatment options available for restoring primary anterior teeth. a clinician's decision to opt for any specific treatment option is based on multiple factors such as the clinician's liking of a specific material or method, esthetic demands by parents, the child's behavior, and moisture and hemorrhage control. out of many treatment options, preformed zirconia crowns for primary teeth have been available for over a decade. there is insufficient research that compares the success of anterior pediatric zirconia crowns with and without retentive grooves.

Eligibility criteria:
inclusion criteria: * healthy 2 to 6-year-old children. * those having opposed anterior teeth. * no history of systemic illness or dental developmental anomalies * minimal of two surfaces of caries in the upper anterior teeth. * patient with early childhood caries. * patients treated under general anesthesia. * english, spanish, and arabic speaking patients exclusion criteria: * teeth nearing exfoliation. * the presence of a single surface caries, not involving the proximal surfaces. * teeth that have been subjected to trauma. * bruxism. * special health needs. * presence of teeth wear on the opposing teeth, or absence of opposing teeth.
use of topical benzocaine for analgesia in lingual frenotomy of the newborn

Conditions: Neonatal Tongue-tie; Maternal Nipple Pain Upon Breastfeeding; Neonatal Latch Difficulties

Summary: frenotomy of tongue-tie is commonly performed to resolve breastfeeding difficulties, eg maternal nipple pain and infant's latching difficulties. the procedure carries minor discomfort for the infants. it is not known whether the use of topical benzocaine, a very bitter tasting material' applied to the tongue-tie would decrease the length of cry. we will measure the duration of crying in infants treated with topical benzocaine to the duration in those not treated with the mediation.


Eligibility criteria:
inclusion criteria: * full term newborn infant * tongue-tie upon physical examination * maternal complains of nipple pain or difficult latch exclusion criteria: * abnormal oral or nasopharyngeal anatomy * any known congenital malformations * prematurity

Keywords: tongue-tie ankyloglossia
concentrated platelet rich fibrin (c-prf) as adjunct to non-surgical periodontal therapy

Conditions: Periodontal Pocket

Summary: the current study is a prospective randomised split mouth study to evaluate the effect of concentrated platelet rich fibrin as an adjunct to the scaling and root planing

twelve healthy individuals satisfying the inclusion and exclusion criteria were recruited for the study. a detailed, thorough medical and dental history was obtained and each patient was subjected to comprehensive clinical and radiological examination. all patients were informed about the nature of the study, procedure involved, potential benefits and risks associated with procedure and written informed consent were obtained from all patients. all the patients underwent scaling and root planing. as it is split mouth study design the test site is treated with concentrated platelet rich fibrin( c-prf) and the contralateral site is not treated with c-prf. periodotal pack was placed and patient was recalled after 6 weeks for the follow up.

Eligibility criteria:
inclusion criteria: 1. patient age ranging from 18-45 years 2. contralateral sites with probing depth 5mm-7mm associated with premolar and molar teeth with no furcation involvement 3. no systemic disease 4. not under any medication which effect the outcome of periodontal therapy exclusion criteria: 1. history of any periodontal therapy within past 6 months 2. pregnant and lactating mothers 3. smokers smoking \>10 cigarettes per day 4. patients with blood disorders or platelet count less than 50000 cells/ µl 5. patients with known systemic disease 6. non-compliant patients
relationship between bladder distention and hysteroscopy application

Conditions: Menorrhagia

Summary: the purpose of the study is to investigate the advantages and disadvantages of bladder filling during hysteroscopy procedure.

women who should have diagnostic hysteroscopy procedure will be randomly allocated into two groups. in the first group hysteroscopy will be performed with a filled bladder and in the second group procedure will be performed with an empty bladder. the women will be assigned into groups randomly. the duration of the procedure, feasibility of the procedure and tolerability of procedure will be recorded.

Eligibility criteria:
inclusion criteria: * women who are at reproductive age * women who are not pregnant at the time of presentation * women who are not nulliparous exclusion criteria: * women who have previous cervical surgery or cervical incompetence. * women who have genitourinary infection * women who have profuse uterine bleeding or recent uterine perforation * women who have neurological disorders affecting evaluation of pain.

Keywords: hysteroscopy bladder pain feasibility duration
comparison of detection and miss rates of blue laser imaging versus conventional white light colonoscopy

Conditions: Colorectal Adenoma

Summary: it is a randomized controlled trial with tandem colonoscopy.participants were randomized for use of either blue laser imaging or conventional white light colonoscopy on withdrawal method.comparison of detection and miss rates of bli group versus conventional white light colonoscopy.

blue laser imaging (bli) are a new imaging systems used in endoscopy which are recently developed. according to three recently published reports, the diagnostic ability of adenoma characterization using blue laser imaging compares favorably with narrow band imaging. no published data are available to date regarding adenoma detection with blue laser imaging.bli has the possibility to increase the detection of colorectal polyps by sufficient brightness and clearer endoscopic images.the investigators recruited participants who underwent colonoscopy for symptoms,screening,or surveillance.participants were randomized for use of either blue laser imaging (bli) or conventional white light colonoscopy on withdrawal method.lesions detected on first-pass and second-pass examination were used for adenoma detection and miss rates,respectively.the primary outcomes is to compare the adenoma and poly detection rates of bli with conventional white light colonoscopy.

Eligibility criteria:
inclusion criteria: * consecutive patients who were underwent colonoscopy in our center for diagnostic work up of colonic symptoms,surveillance of colorectal polyps, and colorectal cancer screening. exclusion criteria: * history of colon cancer, colectomy familial adenomatous polyposis, or inflammatory bowel diseases; * severe intestinal stenosis or obstruction;coagulation，disorders; * pregnancy; * and colonoscopy examinations with inadequate bowel cleanliness

Keywords: blue laser imaging,detection,randomized trial
safety and efficacy of zinc supplementation in hiv-1-infected children in south africa

Conditions: HIV Infections

Summary: the goal of the study is to rule out a harmful effect of zinc supplementation in hiv-1-infected children. the null hypothesis is that zinc supplementation will increase plasma hiv rna levels.

a randomized, double-blind, placebo-controlled equivalence trial of zinc supplementation was conducted at grey's hospital in pietermaritzburg, south africa. ninety-six hiv-1-infected children were randomly assigned to receive 10 mg of elemental zinc as sulfate or placebo daily for 6 months. baseline measurements of plasma hiv-1 viral load and the percentage of cd4+ t-lymphocytes were established at two study visits prior to randomization, and measurements were repeated 3, 6 and 9 months after starting supplementation. plasma hiv-1 viral load and the percentage of cd4+ t-lymphocytes were compared before and after supplementation.

Eligibility criteria:
inclusion criteria: * hiv-infection * 6 to 60 months of age * not receiving antiretroviral therapy * cared for as outpatients at grey's hospital exclusion criteria: * receiving antiretroviral therapy

Keywords: zinc hiv children
nurse-led clinic for patients with rheumatic diseases and biological treatment

Conditions: Rheumatic Diseases

Summary: randomized controlled trial including 100 subjects with rheumatic diseases and biological treatment with a 28 point-disease activity score(das28)3.2 or less. the subjects will be randomized to either nurse-led clinic or rheumatologist-led clinic. the hypothesis is that there will be no difference in das28 between the two groups after 1 year follow-up.

aim to compare nurse-led clinic and rheumatologist-led clinic regarding results of treatment, and health economic costs. intervention rheumatologist-led clinic: the subjects are seeing a rheumatologist after six months and after 12-months of intervention and have the possibility to contact the rheumatology clinic. nurse-led clinic: the subjects are seeing a rheumatology nurse after six months and a rheumatologist after 12 months of intervention and have the possibility to contact the rheumatology nurse during the intervention. outcome measures: main outcome: das28 and costs for the clinics respectively. secondary outcome: haq (health assessment questionnaire), vas-pain (visual analog scale), vas-global health, vas-satisfaction, vas-security/trust, tender joints, swollen joints, quality of life-eq5d, effective consumer survey 17, inflammatory parameters in blood.

Eligibility criteria:
inclusion criteria: * subjects with rheumatologic diseases and biological treatment with a das28 of 3.2 or less exclusion criteria: * the subjects should not have problems with infections due to treatment * subjects with difficulties speaking and/or reading swedish

Keywords: rheumatic diseases biologic treatment nurse-led
cooling via cryogenx body cooling device

Conditions: Body Temperature Changes

Summary: the aim of this project is to test the rate of cooling following exercise in the heat utilising the cryogenx cryosuit device i) against passive cooling, and ii) to quantify the rate of cooling and compare this rate with established cooling intervention thresholds i.e. -0.11 to 0.15°c.min-1. as this project is to determine the efficacy of the intervention in populations equivalent to sporting and military personnel, these aims will be tested in young (18-40 year old) healthy male and female participants whom participate in regular physical activity. as a commercially funded project, the experimental design implemented will closely replicate that of the independent investigation into the efficacy of the caervest® device.


Eligibility criteria:
the inclusion criteria are: aged 18 - 40 years free from known injury, illness and disease and regular use of medications other than oral contraceptives undertake exercise training \>3 times per week for \~30 minutes per session the exclusion criteria are: pregnant previous history of neuromuscular fatigue previous history of heat intolerance
prediction of chronic postsurgical pain in adults

Conditions: Chronic Postsurgical Pain; Acute Post Operative Pain

Summary: this research will be a prospective single-centre observational cohort study in denmark spanning approximately one year. the objective of this study is to develop a clinically applicable and generalizable prediction model for postsurgical pain in adults.


Eligibility criteria:
inclusion criteria: * consenting danish-speaking adults aged 18 years and older * patients who undergo common inpatient or outpatient surgical procedures exclusion criteria: * patients with cognitive impairment * patients who refuse or unable to provide informed consent * patients who undergo re-operation within 3 months of their initial surgery
the efficacy of suprainguinal fascia iliaca compartment block for analgesia after elective total hip replacement.

Conditions: Anesthesia, Local; Analgesia; Arthropathy of Hip

Summary: total hip replacement surgery is one of the most common orthopedic interventions. proper anaesthesia and adequate analgesia is one of the key interests of attending anaesthetist. recent studies show that ultrasound guided suprainguinal fascia iliaca compartment block may play a significant role in proper management of pain after these procedures. the aim of this study was to assess the clinical usefulness and compare different methods of anaesthesia for total hip replacement surgery via posterolateral approach.


Eligibility criteria:
inclusion criteria: * age 18-75 years old * informed consent to participate in the study * asa score i-iii * bmi -19-30kg/m2 * qualified for total hip replacement * no contraindication to used anesthesia and drugs exclusion criteria: * contraindications to spinal anesthesia and regional blocks * previously coexisting chronic pain * previously opioids intake * bmi\>30kg/m2 * allergy to drugs using during study * mental status preventing the usage of patient controlled analgesia pump
a brief intervention to improve adherence in teens with inflammatory bowel disease

Conditions: Inflammatory Bowel Disease

Summary: this project will test if a phone intervention can improve the medicine-taking behavior of teens with ibd. the investigators will study teens who are taking medicine by mouth. the investigators will test if two phone calls that help teens solve problems with their ibd medicine help to increase how often teens take their medicine. the study will also see if there is any extra benefit of more sessions (four compared to two). the investigators will ask 90 teens to be in the study. teens can be in the study if they are 11-18 years old and speak english. they must also take an ibd medication by mouth and have a parent who also wants to be in the study. teens who agree to be in the study will fill out forms at the beginning (participant week 0), middle (participant week 12), and end of the study (participant week 20). after assessment 1, they will be randomly assigned to either receive 2 phone calls or a wait list group (participant weeks 6-10). after that, they will complete a second assessment. after the second assessment, teens who got the 2 phone calls right will be re-randomized to two more sessions or no more sessions (participant weeks 14-18). teens who were in the wait list group will get two phone sessions (participant weeks 14-18). after that, there will be a final assessment (participant week 20). the investigators expect the phone intervention sessions to reduce barriers to medicine taking, improve medicine taking, and improve teen quality of life.


Eligibility criteria:
inclusion criteria: * patient age 11-18 years * patient english speaking * patient legal guardian willing to participate * patient on oral ibd maintenance medication for 3 months or longer exclusion criteria: * history of significant parent-reported cognitive or developmental delay

Keywords: inflammatory bowel disease ibd crohn's disease ulcerative colitis adolescent