Kornimate/medical-research-clean huggingface dataset:
phytoestrogen, no donors, n-acetyl cysteine add therapy to clomiphene citrate to improve pregnancy rate in pco patients

Conditions: Infertility

Summary: to evaluate the effect of oral phytoestrogen or isosorbid mononitrate or n-acetyl cysteine as an adjuvant to clomiphene citrate on induction of ovulation and pregnancy outcomes in patients with pcos. in this three-arm open rct, 240 pcos infertile women were randomly divided to 3 groups for induction of ovulation. group a, \[pe group, n= 80\] patients received cc 100mg/d plus oral phytoestrogen120 mg/ day and patients in group b, \[ismn group, n=80\] received cc 100 mg/d plus 20 mg isosorbid mononitrate and group c, \[nac group, n=80\] patients received cc 100 mg/d plus nac 1200 mg/day.


Eligibility criteria:
inclusion criteria: 1. all patients have pcos. 2. all patients received cc 100 mg/day for 5 days starting from day 5 with successful ovulation as documented by folliculometry and midluteal serum progesterone with no pregnancy achieved. 3. all patients have patent fallopian tubes by hysterosalpingography. 4. their husbands have normal semen analysis according to the modified criteria of who. 5. all patients have normal serum prolactin and thyroid profile. 6. any patient having vaginitis was treated before starting induction. exclusion criteria: 1. other causes of infertility than anovulation. 2. diabetes or other endocrinological disorders. 3. age \> 40 years. 4. smoking. 5. alcohol use. 6. presence of ovarian cyst \>2cm on the second day of the cycle. 7. patients who have received gonadotrophins in the preceeding 6 months. 8. patients who have done unilateral or bilateral ovarian drilling. 9. allergy to pe, no donors or nac
prevalence of distal radial artery occlusion in cardiovascular catheterization via distal radial access

Conditions: Catheterization; Complications; Distal Radial Artery

Summary: explore the prevalence of distal radial artery occlusion after cardiac catheterization via distal radial artery and the risk factors

cardiac catheterization via distal radial artery is prevalent worldwide, which can reduce the prevalence of radial artery occlusion. however, the distal radial artery occlusion has not been detected. this study is designed to explore the prevalence of distal radial artery occlusion in patients undergoing cardiac catheterization via distal radial access at 1 day and 3 months after the procedure, which is explored by ultrasound. in addition, the risk factors of distal radial artery occlusion are also analyzed.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years; * palpable distal radial artery exclusion criteria: * age ≥ 90years; * height≥ 185cm; * cardiogenic shock; * refuse to sign the written informed consent.

Keywords: distal radial artery occlusion;cardiac catheterization
a survey of susoctocog alfa (genetical recombination) in participants with acquired haemophilia a

Conditions: Acquired Hemophilia A

Summary: this study is a survey in japan of susoctocog alfa (genetical recombination) intravenous injection used to treat participants with bleeding events of acquired haemophilia a (aha). the study sponsor will not be involved in how the participants are treated but will provide instructions on how the clinics will record what happens during the study. the main aim of the study is to check for side effects related from susoctocog alfa (genetical recombination) intravenous injection and to check if susoctocog alfa (genetical recombination) intravenous injection improves bleeding events of aha. during the study, participants with aha will take susoctocog alfa (genetical recombination) intravenous injection according to their clinic's standard practice. the study doctors will check for side effects from susoctocog alfa (genetical recombination) intravenous injection for up to 90 days after the last dose of study drug or until discontinued (varied from participant to participant).


Eligibility criteria:
inclusion criteria: - all participants with acquired haemophilia a, treated with susoctocog alfa (genetical recombination). exclusion criteria: - none
patients treated for wiskott-aldrich syndrome (was) since 1990

Conditions: Wiskott-Aldrich Syndrome

Summary: wiskott - aldrich syndrome (was) is a rare serious medical condition that causes problems both with the immune system and with easy bruising and bleeding. the immune abnormalities cause patients with was to be very susceptible to infections. depending on the specific type of primary immune deficiency diseases, there are effective treatments, including antibiotics, cellular therapy and gene therapy, but studies of large numbers of patients are needed to determine the full range of causes, natural history, or the best methods of treatment for long term success. this multicenter study combines retrospective, prospective and cross-sectional analyses of the transplant experiences for patients with was who have already received hct since 1990, or who will undergo hematopoietic cell transplant (hct) during the study period. the retrospective and prospective portions of the study will address the impact of a number of pre and post-transplant factors on post-transplant disease correction and ultimate benefit from hct and the cross-sectional portion of the study will assess the benefit of hct 2 years post-hct in consenting surviving patients.


Eligibility criteria:
inclusion criteria: * was participants will be defined as males who have: 1. thrombocytopenia (\< 100k) and either molecular diagnosis of was or reduced wasp expression; or 2. thrombocytopenia (\< 100k) and positive family history consistent with was diagnosis; or 3. chronic thrombocytopenia (\< 100k for minimum of 3 months) and low mean platelet volume (mpv below normal range for age) and either recurrent and/or severe infections requiring treatment and/or eczema or lack of antibody response to polysaccharide antigens or low igm. * longitudinal analysis (retrospective and prospective) 1. stratum a. participants with was who have or will receive hct * participants with was who have received an hct since january 1, 1990 2. stratum b. participants with was who have or will receive gene transfer * participants in which the intention is to treat with gene transfer with autologous modified cells * cross-sectional analysis (strata a and b) 1. participants with was who are surviving and at least 2 years after the most recent hct or gene therapy. exclusion criteria: * as this is a natural history study, for both the longitudinal analysis and the cross-sectional analysis we will not exclude any patients due to race or age who fit the inclusion criteria.

Keywords: wiskott-aldrich syndrome hematopoietic stem cell transplantation genetic therapy
study of co-administration of olmesartan medoxomil plus amlodipine in patients with mild to severe hypertension

Conditions: Hypertension

Summary: this study assesses the efficacy and safety of co-administration of olmesartan medoxomil plus amlodipine in mild to severe hypertensive patients older than 18 years of age


Eligibility criteria:
inclusion criteria: * male or female patients * 18 years of age or older (20% equal to or older than 65 years) * with mild to severe hypertension defined as seated diastolic blood pressure of 95-120 mmhg while off any hypertensive medication exclusion criteria: * patients should not have serious concomitant conditions that could interfere with the analysis of the results or that could interfere with the well-being of the patients

Keywords: treatment of high blood pressure in mild to severe hypertensive patients
effects of activity and education program on patients with chronic hepatitis c infection

Conditions: Hepatitis C Virus Infection, Response to Therapy of

Summary: this 4-year project will be guided by a biobehavioral model for the study of exercise interventions in two phases with the purposes to : 1. explore the patients' physical activity preferences and develop doable activity lists during treatment period 2. examine the changes of health-related physical fitness component over interferon treatment 3. develop the personalized physical activity and psych-education (ppape) program and test its effects on decreasing fatigue, physical and psychological distress, and improving their health-related physical fitness and quality of life in patients with chronic hepatitis c receiving interferon with ribavirin combination therapy 4. evaluate the outcome of the ppape program on increasing adherence to therapy, the sustained virological response (svr) in 24 weeks after the end of treatment, and the time-consuming for education program during intervention.


Eligibility criteria:
inclusion criteria: * patients with chronic hepatitis c infection receiving interferon therapy * aged above 18 exclusion criteria: * none

Keywords: fatigue,physical activity,hepatitis c virus infection
efficacy and safety of prophylactic treatment for pneumocystis jirovecii pneumonia in patients with autoimmune inflammatory rheumatic disease

Conditions: Pneumonia, Pneumocystis; Autoimmune Inflammatory Rheumatic Disease; Autoimmune Diseases; Connective Tissue Disease; Prevention

Summary: this is an open-labeled, prospective clinical study aims at collecting and analyzing baseline characteristics of autoimmune inflammatory rheumatic disease (aiird) patients receiving sulfanilamide for preventive purposes, as well as subsequent follow-up data, in order to assess the efficacy and safety of the medication. additionally, through a stratified analysis of risk factors, the investigators aim to identify the aiird population that would benefit most from preventive medication based on a favorable benefit-risk ratio.


Eligibility criteria:
inclusion criteria: 1. the patient was diagnosed with aiird according to the international classification of diseases and had received steroids or immunosuppressive therapy; 2. the patient had not received standard pjp treatment before enrollment, including the first-line treatment drug tmp/smz, or other second-line treatment drugs (including pentamidine, atorvastatin, caspofungin, etc.); 3. the patient was at least 18 years old at the time of enrollment; exclusion criteria: 1. serious health problems or diseases, including (but not limited to) the following: severe liver damage (alt, ast elevated above normal value by more than 5 times), severe renal insufficiency (gfr \ 445umol/l), severe myelosuppression (hb \< 65g/l, plt \< 25×10\^9/l or neutrophils \< 0.5×10\^9/l); 2. screening test indicates infection with human immunodeficiency virus (hiv), history of lymphomatous hyperplasia of the lymphatic tissue or any malignant tumor of any organ system within the past 5 years, or history of organ transplantation; 3. participants with a history of allergy to sulfonamide drugs, megaloblastic anemia due to folate deficiency; 4. pregnant and lactating women; 5. any medical or psychological condition that the investigator believes would interfere with the participant's ability to comply with the protocol or complete the study; 6. patients who refuse to comply with the requirements of this study and complete the study; 7. any other situation that the investigator considers unsuitable for participation in the study (for reasons including but not limited to management reasons).
color doppler ultrasound to locate needle in labor epidural

Conditions: Labor Pain; Obstetric Pain

Summary: color flow doppler (cfd) utilizes doppler information obtained from signals sent to and received from a transducer. this information is color-encoded and then displayed as color on an overlay of the two-dimensional image. the color scale represents both speed and direction of flow within a discrete area of the image. cfd has been recently used to determine the position of the epidural catheter. however its role in labor epidural has yet to be defined. this study describes the use of cfd to confirm the position of the tip of the epidural needle in the context of labor analgesia. this study hypothesized that cfd is a feasible method for identifying proper epidural needle placement prior to epidural catheter advancement.

after obtaining approval by the institutional review board and a waiver of informed consent, thirty-five pregnant patients who underwent an ultrasound guided labor epidural between august of 2017 and june of 2018, were included in this retrospective review. the ultrasound guided labor epidural was used in those in which an anticipated technical difficulty with landmark epidural space localization was expected. these included those patients with diagnosis of obesity and lumbar scoliosis, as well as those with poorly defined surface lumbar bone anatomy. patients with history of spine surgery were excluded. patient data were obtained from the institutional electronic medical records. demographic data, intervertebral level of insertion, dermatome level, and failure rate of epidural needle placement using color flow doppler were noted for each patient. labor analgesia was obtained via a combined spinal epidural technique. sterile preparation and draping of the area was followed by placement of a curvilinear ultrasound transducer in a sterile sheath. the ultrasound was used to identify the interspinous space. the epidural needle was guided with the use of real time ultrasound by the use of an out of plane technique. a two hand technique was used to manipulate the needle and the ultrasound probe. a 17g tuohy needle (b. braun medical inc, bethlhem, pa, usa) was advanced until loss of resistance to normal saline was attained. confirmation of the epidural space with the use of color flow doppler (cfd) was then obtained after injection of up to 10 ml of normal saline through the epidural needle. a 27g pencil-point spinal needle (b. braun medical inc, bethlhem, pa, usa) was then introduced through the epidural needle until cerebro-spinal fluid (csf) was obtained. use of intrathecal fentanyl or local anesthetic plus fentanyl was then used as a bolus in the spinal space. a 21g epidural catheter (b. braun medical inc, bethlhem, pa, usa) was then threaded into the epidural space.

Eligibility criteria:
inclusion criteria: • pregnant patients who had labor epidural placed for clinical indications, in whom ultrasound was used to assist the procedure. exclusion criteria: * poor quality ultrasound images judged by experienced anesthesiologist * patients with history of lumbar spine surgery
the effects of high-flow nasal oxygen on oxygenation during rigid bronchoscopy under general anesthesia in pediatric patients

Conditions: Foreign Bodies; Tumor; Stenosis of Trachea; Bronchus

Summary: the aim of this study is to evaluate the effect of high-flow nasal cannula oxygen administration on maintenance of oxygenation and removal of carbon dioxide during apnoeic period in pediatric patients undergoing general anesthesia with rigid bronchoscopy


Eligibility criteria:
inclusion criteria: * 1. patients undergoing general anesthesia with stent placement or bougination, biopsy or removal of a foreign body or a mass through a rigid bronchoscope * 2. patients aged 7 or younger who meet american society of anesthesiologists (asa) physical class 2-4 exclusion criteria: * 1. patients undergoing extracorporeal membrane oxygenation (ecmo) * 2. patients with active nasal bleeding), severe nasal obstruction, recent nasal trauma of surgery * 3. patients with current maxillofacial trauma or basal skull fracture * 4. patients with active nasal bleeding), severe nasal obstruction, recent nasal trauma of surgery * 5. extremely low birth weight infant and premature infant less than 28 weeks gestation age * 6. patients who had previously undergone rigid bronchoscopy / surgery * 7. if the parent of subject includes a person who can not read the written consent (eg, illiterate, foreigner, etc.)
comparison of rehabilitation intervention, supported by telemedicine, with standard rehabilitation after distal radius fracture.

Conditions: Distal Radius Fracture

Summary: this is a randomized clinical trial of two parallel arms, aiming to compare two rehabilitation interventions: an experimental intervention including telemedicine support and remote monitoring of compliance of usual indicated exercises, versus the usual protocol of indicated exercises supported by printed material (triptych) and without remote monitoring

distal radius fracture is a common pathology. the surgical indication is given by the difficulty in obtaining fracture reduction or by the instability of the fracture. the long-term functional prognosis of the wrist depends largely on patients' adherence to the prescribed indications/exercises in the immediate postoperative phase. this is a randomized clinical trial of two parallel arms, aiming to compare two rehabilitation interventions: an experimental intervention including telemedicine support and remote monitoring of compliance of usual indicated exercises, versus the usual protocol of indicated exercises supported by printed material (triptych) and without remote monitoring.

Eligibility criteria:
inclusion criteria: * distal radial fracture (a2 to c3 type according to the orthopaedic trauma association classification system) * indication for standard rehabilitation post-surgery exclusion criteria: * immediate post-surgery complication * multiple fractures or severe injuries * history of bone metabolism condition * illiterate * non-spanish speaking * mental disorder * not familiar with electronic devices

Keywords: rehabilitation information technologies
patients with alzheimer disease, spouse carers and risk of institutionalization: a prospective observational cohort study of dyads (aid study)

Conditions: Alzheimer Disease

Summary: the primary objective of aid study is to identify the medico-neuropsychological, socio-economic and environmental baseline characteristics of dyads associated with the institutionalization of ad patients.

in order to reduce alzheimer disease (ad) adverse impacts at individual level as well as in terms of expenditures, the development of efficient strategies based on the identification and the correction of risk factors of institutionalization of ad patients proves necessary. while it has been identified that institutionalization date depends on patients' health characteristics, the role of social, economic and environmental factors still remains few known. the investigators hypothesized that institutionalization of ad patients could be related not only to medico-neuropsychological patients' characteristics but also to socio-economic and environmental characteristics of dyad (i.e., ad patient and spouse carer), that could modify the delay of institutionalization.

Eligibility criteria:
inclusion criteria: * eligibility criteria for ad patients were: * over age 65, * diagnosis of ad according to the nincds-adrda ( national institute of neurological and communicative disorders and stroke and the alzheimer's disease and related disorders association) criteria, * last memory center consultation between 6 and 12 months before the inclusion, * being affiliated to the french health insurance, * living at home, * having a caregiver with inclusion criteria, * agreement of general practitioner (gp) of ad patient to participate in the study and affiliation of the gp to the national "association pour le développement de l'information médicalisée" (adim) french network. * eligibility criteria for spouse carers were: * over age 65, * being the spouse and the caregiver of ad patient, * being affiliated to the french health insurance, * living at home with ad patient. exclusion criteria: * non inclusion criteria for ad patients and spouse carers were: * an inability to understand and speak french, * acute disease in the past month of baseline assessment, * expected moving outside the recruitment area during the follow-up period * concomitant participation in a clinical trial.
to evaluate the hormonal response to low blood sugar after a single oral dose of azd1656 suspension

Conditions: Type 2 Diabetes

Summary: to evaluate the hormonal response to low blood sugar after a single oral dose of azd1656 suspension.


Eligibility criteria:
inclusion criteria: * healthy male volunteers. * clinically normal physical findings (incl. electrocardiogram (ecg)) and laboratory values as judged by the investigator. * have a body mass index (bmi) ≥19 and ≤30 exclusion criteria: * clinically significant illness or clinically relevant trauma, as judged by the investigator, within 2 weeks before the first administration of the investigational product * intake of any prescribed medicine and otc drugs (including herbals, vitamins and minerals), except for occasional paracetamol or nasal spray for nasal congestion, within two weeks before the first administration of the investigational product. * daily use of nicotine containing substances.

Keywords: type 2 diabetes, hormonal response
the impact of single-shot adductor canal block versus continuous femoral nerve block on rehabilitation after total knee replacement

Conditions: Osteo Arthritis Knee; Gonarthrosis

Summary: total knee replacement (tkr) is considered the most effective and safe method of radical treatment of late stages of knee osteoarthritis. a well-known problem of tkr is a severe postoperative pain syndrome, which is observed in more than 50% of patients. femoral nerve block (fnb) is the "gold standard" for continuous postoperative analgesia after total knee replacement, as it is effective in reducing the frequency of use of opioid analgetics and reduce the duration of hospitalization. at the same time, the negative effect of this method is the motor blockade of the quadriceps femoris muscle which leads to functional impairment and is associated with an increased risk of falling. adductor canal block (acb) provides adequate analgesia comparable to femoral nerve block. moreover, acb doesn't affect the motor function of the quadriceps femoris muscle. the possibility of enhanced recovery after total knee replacement is the reason to compare single-shot adductor canal block and continuous femoral nerve block.


Eligibility criteria:
inclusion criteria: * age ≥ 18 * planned primary total knee replacement * planned neuraxial anesthesia * written informed consent exclusion criteria: * urgent surgery * planned revision total knee replacement * known allergic reaction to anesthetics * confirmed localized infection at the puncture sites * confirmed localized tumor at the puncture sites * peripheral neuropathy of the lower extremities * parkinson's disease * previously enrolled in this trial

Keywords: osteo arthritis knee gonarthrosis regional anesthesia analgesia postoperative analgesia total knee replacement continuous femoral nerve block femoral nerve block continuous adductor canal block adductor canal block
effects of nitrous oxide: a dose-response analysis - 5

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Summary: the purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. to examine the subjective, psychomotor, and reinforcing effects of nitrous oxide in healthy volunteers. this is a dose-response analysis.


Eligibility criteria:
please contact site for information.

Keywords: nitrous oxide inhalant subjective effects healthy volunteer