Kornimate/medical-research-clean huggingface dataset:
isolated maxillary sinus lesions in sohag university hospital

Conditions: Maxillary Sinus Disease

Summary: aim of the study: identify variants of maxillary sinus pathologies, its clinical presentations, radiological findings and surgical managements.

maxillary sinus diseases are common and numerous disorders that affect this anatomical area. as lesions are frequently allowed to grow to a significant size before becoming symptomatic, patients often present late, which can make management options more limited and difficult. proper evaluation both clinically and with appropriate imaging allows accurate diagnosis, and lesions can often be successfully managed endoscopically

Eligibility criteria:
inclusion criteria: * only patients with isolated maxillary sinus lesions , with varying degrees of sinus opacity who were indicated for surgery. exclusion criteria: * patients who had pan sinuses lesions or those with significant involvement of the other paranasal sinuses than maxillary sinus were excluded.
pmcf (post-market clinical follow-up) study on the tether™ in uk (united kingdom)

Conditions: Scoliosis Idiopathic

Summary: the goal of this observational study is to collect information about the tether™ device in participants with progressive idiopathic scoliosis, lenke type 1 curves. the main purpose is to provide assessment of: * ongoing safety * probable benefits participants who will receive the tether™ during spine surgery will have to attend follow-up visits which are part of standard-of-care.

this study is designed to be prospective. after the initial visit, followed by the surgery, the participant is expected to take part in the study for a time period of 5 years post-surgery. patients will be enrolled during a period of 36 months, and the study will last until complete collection of the 5-year follow-up data. data will be collected at: first follow-up post discharge, 6, 12, 24, 36, 48 and 60 months.

Eligibility criteria:
inclusion criteria: * diagnosis of progressive idiopathic scoliosis; * skeletally immature, based on both risser (\<5) and sanders (\<8) assessments; * major cobb angle ≥30° and ≤65°; * osseous structure dimensionally adequate to accommodate screw fixation, as determined by radiographic imaging; * failed bracing and/or be intolerant to brace wear; * lenke type 1 curves (i.e., main thoracic); * signed informed consent form by legal guardian or by the patient if ≥ 16 years old. * the decision to treat patients with the tether™ - vbt system was made by the patient's clinician outside of this research exclusion criteria: * presence of any systemic infection, local infection, or skin compromise at the surgical site; * prior spinal surgery at the level(s) to be treated; * known poor bone quality defined as a t-score -1.5 or less; * skeletal maturity; * any other medical or surgical condition which would preclude the potential benefit of spinal surgery, such as coagulation disorders, allergies to the implant materials, and patients unwillingness or inability to cooperate with post-operative care instructions; * unwillingness, inability, or living situation (e.g., custody arrangements, homelessness, detention) that would preclude ability to return to the study site for follow-up visits as described in protocol and informed consent; * patients who are pregnant at the time of enrollment.

Keywords: vertebral body tethering fusionless spine surgery
isolated pelvic and limb perfusion in the treatment of locally advanced sarcoma of pelvis and limbs' girdle

Conditions: Sarcoma of Pelvis

Summary: this study looks at isolated pelvic perfusion and limbs' girdle with 1 mg tumor necrosis factor alpha (tnfa) in the treatment of locally advanced sarcoma of the pelvis and limbs' girdle.


Eligibility criteria:
inclusion criteria: * soft tissue or bone sarcomas locally advanced of the pelvis or limbs' girdle exclusion criteria: * resectable tumor without mutilation

Keywords: limbs' girdle
transversus abdominis plane block versus erector spina plane block

Conditions: Intraoperative Pain Control

Summary: regional anesthesia and analgesia techniques are frequently used to provide pain control in pediatric surgical applications. the main advantages of these techniques include ease of application, good analgesic efficacy and low risk of complications (1). it reduces the need for parenteral opioids and increases the quality of postoperative pain control and the satisfaction of the patient and family (2). the aim of this study was to compare the contribution of tap block and esp block combined with sedation in pediatric surgery to anesthesia and analgesia during surgery without general anesthesia.


Eligibility criteria:
inclusion criteria: * asa i-ii, * undergo elective lower abdominal surgery * 2-6 years exclusion criteria: * psychiatric patients, * weight\> 40 kg, * those with cardiac-pulmonary-neurological disease, * those with bleeding disorders, * infection or wound scarring at the injection site, * known allergy to local anesthetics
fibrinogen concentrate in children after cardiac surgery

Conditions: Cardiac Surgical Procedures; Blood Coagulation Disorders; Fibrinogen; Cryoprecipitate

Summary: the purpose of this study is to evaluate prospectively whether concentrate fibrinogen reduces blood losses, transfusion requirements and occurrence of clinical complications compared to cryoprecipitate in children after cardiac surgery with pump.

cardiac surgery in children may be associated with excessive perioperative bleeding. perioperative excessive bleeding is associated with need of transfusion with allogeneic blood products such as red blood cells, fresh frozen plasma, platelet pools, and cryoprecipitate. furthermore, bleeding may result in re-exploration, which is associated with increased morbidity and mortality.recent studies have shown that patients and children undergoing cardiac surgery with pump often experience a significant drop in their levels and function of fibrinogen, and it would be in part responsible for the bleeding. in most centre world-wide, it is common practice to treat bleeding in these patients with cryoprecipitate in order to substitute fibrinogen. fibrinogen concentrate (haemocomplettan p)may reduce perioperative bleeding, requirements of blood transfusion and clinical outcomes in children undergoing cardiac surgery with pump, compared to cryoprecipitate.

Eligibility criteria:
inclusion criteria: * cardiac surgery with pump * age until 18 years * written informed consent * clinically important bleeding in intraoperative * fibrinogen lower than 1 g/l or teg \< 7 mm exclusion criteria: * previous coagulopathy (clinical history or inr \> 1.5) * low platelet count (lower than 100.000) * product allergy * urgent procedures * active infection

Keywords: cardiac surgical procedures fibrinogen bleeding cryoprecipitate
ovarian mesial incision: a new safe and fertility-sparing technique

Conditions: Dermoid Ovarian Cysts

Summary: the purpose of this study is to evaluate safety and efficacy in terms of spillage risk and fertility-sparing of mesial incision for laparoscopic dermoid cystectomy.


Eligibility criteria:
inclusion criteria: * reproductive age * pre-operative findings suggestive for benign tumor * regular menstrual cycles at least six months before surgery exclusion criteria: * previous pelvic surgery * known endocrine disease * estrogen-progestin use before surgery
effect of red wine, white wine and beer on contrast-medium induced acute kidney injury

Conditions: Chronic Renal Failure/ Kidney Disease; Contrast-medium Induced Acute Kidney Injury

Summary: patients with impaired renal function are at elevated risk for development of contrast-medium induced acute kidney injury (ci-aki). ci-aki is associated with increased risk for cardiovascular morbidity and mortality. effective ci-aki prevention strategies are needed. the renpro-ii-wine trial was designed to test the hypothesis whether moderate red wine consumption prior to contrast-medium use is effective in ci-aki prevention. consecutive patients with impaired renal function undergoing elective coronary angiography will be assigned in one of four treatment arms: a. control patients receiving standard care b. patients receiving standard care plus red wine c. patients receiving standard care plus white wine d. patients receiving standard care plus beer this study will give important answers on how to prevent ci-aki in patients with impaired renal function undergoing contrast media exposure.


Eligibility criteria:
inclusion criteria: * age \>= 18 years * impaired renal function (baseline estimated glomerular filtration rate of \<60 ml/min) * at least three of following comorbidities: hypertension, diabetes mellitus without insulin therapy, heart failure nyha iii and/or left ventricular ejection fraction \<35%, peripheral artery disease, coronary artery disease exclusion criteria: * known alcohol addiction * severe renal impairment (estimated glomerular filtration rate \<15 ml/min and/or in chronic dialysis program * recent (\<=30 days) contrast media exposure * insulin therapy * patients enrolled in concomitant studies * fertile women
combined anodal transcranial direct current stimulation (tdcs) and cognitive training and decision-making

Conditions: Impulsivity; Decision Making

Summary: this study aims to (i) assess the effects of combined tdcs and cognitive training on decision-making on a trained task (iowa gambling task; igt); and (ii) test generalization to a closely related cognitive domain, namely motor impulsivity. it is hypothesized that combined anodal tdcs and cognitive training will result in more advantageous decisions and better impulse control than combined sham tdcs and cognitive training.

impaired decision-making under conditions of uncertainty and risk has been implicated in maladaptive personality development and violent behaviour. there is a dearth of studies that examined the effects of combined tdcs and cognitive training on decision-making under conditions of uncertainty and risk. it is also unclear if these effects are generalizable to tasks in other domains such as response inhibition (motor impulsivity). to examine these issues further, a single blind parallel arms randomized controlled trial will be conducted, involving a sample of healthy volunteers aged between 18 and 40. this will entail applying either active or sham tdcs over the anterior frontal cortex (including the vm-pfc) while participants undertake decision-making training using the iowa gambling task. decision-making will be assessed using the igt, which is a computerized gambling task used to assess decision-making under conditions of uncertainty and risk. igt is sensitive to damage to the ventromedial prefrontal cortex (vmpfc), which is considered to play a key role in decision-making. motor impulsivity will be measured using the stop signal task (sst). the upps+p impulsive behaviour scale will be used to index trait impulsivity. the profile of mood states will be used to measure state emotion before and after tdcs.

Eligibility criteria:
inclusion criteria: * consenting volunteers aged between 18 and 40. exclusion criteria: * individuals with epilepsy, other neurological conditions and history of significant head injury will be excluded. * individuals with a history of substance misuse, major mental disorder and those receiving psychotropic medication will be also excluded.

Keywords: transcranial direct current stimulation (tdcs) decision-making implusivity brain stimulation
predicting success of hfnc: the utility of the rox index

Conditions: Acute Respiratory Failure; Pneumonia

Summary: the purpose of the study was to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation in pneumonia patients with acute respiratory failure treated with high flow nasal cannula.

purpose the purpose of the study is to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation (mv) in pneumonia patients with hypoxemic acute respiratory failure (arf) treated with high-flow nasal cannula (hfnc). materials and methods this is a 4-year prospective observational 2-center cohort study including patients with severe pneumonia treated with hfnc. high-flow nasal cannula failure was defined as need for mv. rox index was defined as the ratio of pulse oximetry/fraction of inspired oxygen to respiratory rate.

Eligibility criteria:
inclusion criteria: * diagnosis of acute respiratory failure secondary to pneumonia receiving hfnc therapy exclusion criteria: * younger than 18 years old * indication for mechanical ventilation at icu admission * limitation of therapeutic effort

Keywords: high flow nasal cannula success failure rox index
efficacy of small subcutaneous glucagon dose to treat hypoglycemia in adults with type 1 diabetes

Conditions: Type 1 Diabetes

Summary: in the unfortunate case of severe hypoglycaemia, glucagon is the first-line treatment because of its potent and rapid action starting as fast as 5 minutes after subcutaneous or intramuscular injection. large dose of glucagon such as 1 mg subcutaneous is usually associated with undesirable side-effects such as nausea, vomiting, bloating and headache. the overall objective of this research proposal is to assess the efficacy of lower subcutaneous doses of glucagon (0.1 mg or 0.2 mg) to correct hypoglycaemia compared to the standard dose (1.0 mg) in adults with type 1 diabetes mellitus (t1d). it is postulated that much lower dosages of glucagon (0.1 or 0.2 mg) injected subcutaneously will be just as effective as the current recommended dose of 1.0 mg to correct hypoglycaemia without the undesirable gastro-intestinal side effects.

in the unfortunate case of severe hypoglycaemia, glucagon is the first-line treatment because of its potent and rapid action starting as fast as 5 minutes after subcutaneous or intramuscular injection. current instructions for the treatment of severe hypoglycaemia call for the immediate injection of 1 mg of glucagon subcutaneously or intramuscularly. large dose of glucagon such as 1 mg subcutaneous is usually associated with undesirable side-effects such as nausea, vomiting, bloating and headache. moreover, glucagon emergency kits are relatively expensive (around $100 per kit), thus increasing the financial burden of diabetes on patients and the health care system. the primary objective of this research project is to the study the pharmacological effects of different doses of glucagon injected subcutaneously to correct hypoglycaemia during controlled conditions mimicking a hypoglycaemic event in adults with type 1 diabetes. more specifically, we will be looking at the effects of subcutaneous glucagon injected at 0.1 or 0.2 mg and 1.0 mg to normalized plasma glucose during a hypoglycaemic hyperinsulinemic clamp in subjects with type 1 diabetes.

Eligibility criteria:
inclusion criteria: * males and females ≥ 18 years of old * clinical diagnosis of type 1 diabetes for at least two years. exclusion criteria: * clinically significant nephropathy (mdrd \< 60 ml/min/1.73 m2). * pregnancy * severe hypoglycemic episode within two weeks of screening * current use of glucocorticoid medication (except low stable dose) * pheochromocytoma or primary adrenal insufficiency (e.g. addison's disease) * medical condition likely to interfere with study participation or with the ability to complete the trial by the judgment of the investigator.

Keywords: type 1 diabetes hypoglycemia glucagon hypoglycaemic hyperinsulinemic clamp
telerehabilitation on hand-affected scleroderma

Conditions: Scleroderma; Scleroderma, Systemic; Scleroderma Associated Digital Ulcer; Hand Rheumatism; Physiotherapy; Rehabilitation

Summary: telerehabilitation approach on individuals with hand-affected scleroderma

the effects of exercises performed by telerehabilitation on individuals with hand-affected scleroderma on range of motion, grip strength, function, sensation, daily life activities and general health will be compared with the effects of home-exercises. firstly, the evaluation results will be published; and after all data are collected, the results will be published.

Eligibility criteria:
inclusion criteria: * having been diagnosed with scleroderma * stability of medical treatments * to be able to adapt to the exercises exclusion criteria: * the patient has a history of neurological disease or trauma that may affect his symptoms * systemic involvement that affects the treatment process * being in the active phase of the disease

Keywords: scleroderma systemic sclerosis telerehabilitation hand therapy
personalized therapy study - hfrs (triagehf) post approval study

Conditions: Heart Failure

Summary: medtronic is sponsoring the hfrs pas to evaluate the hfrs feature (triagehf) when used in routine clinical practice following commercial release. the hfrs pas is conducted within medtronic's product surveillance registry (psr) platform.

the hfrs pas is a global, prospective, observational, multi-site study. patients implanted with a medtronic cobalt™ xt crt (with attain stabilityquad™ mri surescan™ model 4798 lead (asq)) or icd device who are enrolled in the medtronic carelink (cl) network and the psr will be followed per the standard of care practices of their care provider.

Eligibility criteria:
inclusion criteria: * patient or legally authorized representative provides written authorization and/or consent per institution and geographical requirements * patient has or is intended to receive or be treated with an eligible icd or crt device or patients may be enrolled pre-implant and up to 30 days post-implant following confirmation of patient eligibility. * patient is enrolled in the medtronic carelink® network for remote monitoring. exclusion criteria: * patient who is, or is expected to be inaccessible for follow-up * patient with exclusion criteria required by local law * patient is currently enrolled in or plans to enroll in any concurrent drug and/or device study that may confound results.
single oral doses study of nerispirdine on visual function in patients with multiple sclerosis

Conditions: Multiple Sclerosis; Optic Nerve; Neuritis

Summary: the primary objective of the study was to evaluate the effect of nerispirdine (50 mg or 400 mg) and placebo given orally as a single dose once a week in crossover design on latency of visual evoked potentials (vep) p100 in optic nerves. secondary objectives included evaluation of the effect of nerispirdine on vep amplitude and other visual parameters including visual acuity and contrast, as well as evaluation of the safety and tolerability of nerispirdine in patients with multiple sclerosis (ms). contrast sensitivity and visual acuity examinations (in addition to optical coherence tomography \[oct\] and veps) were needed during the screening period for defining etiologic relationships (if non-ms related impairment) and for assessing the effect of treatment of age-related eye disease versus the ms-related vision impairment.

the crossover design included 3 treatment periods 1 week apart and 6 treatment sequences. study participation were to be 5 weeks.

Eligibility criteria:
inclusion criteria: * clinically definite ms (mcdonald criteria), which includes patients with remitting-relapsing, secondary progressive, progressive-relapsing, or primary progressive ms who have had a past history of optic neuritis. exclusion criteria: * multiple sclerosis exacerbation within 60 days of the screening visit and the relapse involved the visual fields or visual acuity * no eye with appropriate degree of lesions for this study as defined by criteria based on degree of visual acuity deficit, refractive error, vep p100 latency and average retinal nerve fiber layer thickness of as measured by optical coherence tomography (oct) * any ms-unrelated prior ophthalmological impairment (eg, compressive, ischemic, toxic, or nutritional optic neuropathies, leber's hereditary optic atrophy) * previously exposed to 3,4-diaminopyridine or 4-aminopyridine the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Keywords: visual acuity contrast sensitivity visual evoked potentials optical coherence tomography
virtual reality in aphasia rehabilitation

Conditions: Stroke, Ischemic; Aphasia

Summary: virtual reality-based aphasia rehabilitation has been shown to improve the language skills of individuals with aphasia in the chronic period after stroke. however, non-immersive or semi-immersive rehabilitation methods have often been adopted in the studies. considering the importance of the visual given to the patient for naming, it can be thought that full immersive therapy may be more effective. therefore, the aim of this study was to investigate the effect of cue-based aphasia naming therapy in a fully immersive virtual reality environment on aphasia severity and aphasia-related quality of life and to compare it with standard cue treatments.


Eligibility criteria:
inclusion criteria: * diagnosed with non-fluent aphasia by a neurologist * at least 4 months after stroke * a score of 29 and above on the language score sub-item of the gat scale exclusion criteria: * severe sensory impairments (vision, hearing) that prevent participation in therapies * severe motor dysfunction * apraxia * neglect * dementia * psychiatric disorders * 3d vision problems
clinical results of asqelio trifocal toric diffractive intraocular lens

Conditions: Cataract

Summary: the goal of this observational prospective clinical study is to learn about the clinical outcomes three months after binocular implantation of asqelio trifocal toric iol in 30 patients submitted to cataract surgery following standard clinical practice. the main questions it aims to answer are: how rotationally stable is the lens after implantation and how effective is in the correction of refractive astigmatism. additionally, the visual performance at different distances will be assessed, as well as the patient-reported outcomes.


Eligibility criteria:
inclusion criteria: * patients submitted to cataract surgery with phacoemulsification with bilateral implantation of asqelio trifocal toric iol to avoid residual astigmatism * patient signing informed consent * clear intraocular media, except for cataracts in both eyes prior to surgery * monocular potential postoperative visual acuity of 20/25 or better exclusion criteria: * corneal astigmatism lower than 0.75d * patients who do not provide informed consent * patients who do not understand the study procedure * previous corneal surgery or trauma * irregular cornea (e.g. keratoconus) * choroidal hemorrhage * microphtalmos * severe corneal dystrophy * uncontrolled or medically controlled glaucoma * clinically significant macular changes * concomitant severe eye disease * non-age-related cataract * severe optic nerve atrophy * diabetic retinopathy * proliferative diabetic retinopathy * amblyopia * extremely shallow anterior camera * severe chronic uveítis * pregnant or nursing * rubella * mature/dense cataract that makes it difficult to examine the fundus preoperatively. * previous retinal detachment * concurrent participation in other research with drugs or clinical devices * expect to require another eye surgery during the study period

Keywords: cataract surgery intraocular lens