Kornimate/medical-research-clean huggingface dataset:
assessing the diagnostic accuracy of an on-line questionnaire for diagnosis of primary headache disorders

Conditions: Headache Disorders

Summary: purpose of the study is to assess the diagnostic accuracy of an on- line questionnaire in comparison to a semi-structured interview administered by a trained interviewer.

the worldwide current gold standard for diagnosing headaches is the international classification of headache disorders (ichd 3 beta). adhering strictly to ichd criteria has been problematic for accurately diagnosing patients in the clinic and as for clinical trials. to address these issues, an online instrument was developed that successfully diagnosis common primary and secondary headache disorders. in this research investigator hopes to demonstrate an on- line questionnaire is non inferior to a semi-structured interview for accurately diagnosing different types of headaches (for example: episodic migraine vs. non episodic migraine, chronic migraine vs. non chronic migraine, episodic tension-type vs. non-episodic tension type, chronic tension-type headache vs. non chronic tension-type headache, medication overuse headache vs. non medication overuse headache, post traumatic headache vs. non post traumatic headache). participants will be screened by telephone to see if participants meet the criteria for taking part in this research study. once participant is deemed eligible,the participants will then be randomized in a 1:1 ratio to complete either the semi-structured interview over the phone first and then complete the online questionnaire or vice versa. study is expected to enroll 500 participants with headache and healthy controls.

Eligibility criteria:
inclusion criteria: 1. female or male subjects age between age 18-65(inclusive), 2. subjects must agree to sign online informed consent; 3. subject must be able to understand and willing to complete both evaluations in english 4. willing to comply with study instructions. 5. agree not to rely or act on any diagnosis given to them in the study exclusion criteria: 1. presence of disorders listed in groups 5-13 of the international headache society classification of head and facial pain (headache classification committee of the international headache society, 2015 except for post traumatic headache and medication overuse headache); 1a. history of brain tumor, brain surgery 1b. history of brain infection such as meningitis, encephalitis, or meningoencephalitis 1c. history of any significant current or previous brain dysfunction 1d. regular use of illicit drugs. 2. known significant medical or psychiatric disease or abnormal laboratory data that would preclude entry into this study. 3. subjects with - significant cognitive impairment such as dementia, active psychiatric disease such as schizophrenia. 4. subjects with physical limitations to participate in the on-line or phone interview impossible. 5. non-english speaking patients
the effect of a probiotic on protection against upper respiratory tract infections in children

Conditions: Upper Respiratory Tract Infection

Summary: the purpose of this study is to study the effect of a probiotic on protection against upper respiratory tract infections (urti) in children.


Eligibility criteria:
inclusion criteria: * healthy children exclusion criteria: -
phase 1, dose-escalation study of oral cnf2024(biib021) in cll

Conditions: B-Cell Chronic Lymphocytic Leukemia

Summary: cll dosing escalating study; daily dosing schedule; pk/pd safety

phase 1, open-label, accelerated-titration study designed to evaluate the effects of increasing doses of cnf2024 on safety, pharmacokinetics, pharmacodynamic markers, and hematological response

Eligibility criteria:
inclusion criteria: * patients with cll who relapsed following or are intolerant to purine analog -based therapy * hemoglobin \>=9 gm/dl (may be post-transfusion) * total bilirubin \<2 x uln, and alt and ast \<2 x uln * creatinine \<=2 x uln * normal plasma cortisol and acth concentrations * ecog performance status \<=2 * anticipated survival \>=3 months * for men and women of child-producing potential, use of effective contraceptive methods during the study and for one month after treatment * ability to understand the requirements of the study, provide written informed consent and authorization of use and disclosure of protected health information, and agree to abide by the study restrictions and return for the required assessments exclusion criteria: * pregnant or nursing women * treatment with chemotherapy, monoclonal antibody, or radiotherapy within 28 days before entering the study * participation in any investigational drug study within 28 days before cnf2024 administration * patients with secondary malignancy requiring active treatment (except hormonal therapy) * active symptomatic bacterial, fungal, or viral infection including active hiv or viral (a, b, or c) hepatitis * problems with swallowing or malabsorption * diarrhea (excess of 2-3 stools/day above normal frequency in the past month) * gastrointestinal diseases including gastritis, ulcerative colitis, crohn's disease, or hemorrhagic coloproctitis * major surgery of the stomach or small intestine * adrenal dysfunction * patients with life- or function-threatening cll complications (e.g., cord compression, hemolytic crisis, urinary tract obstruction) * any illness or condition that in the opinion of the investigator may affect safety of treatment or evaluation of any the study's endpoints

Keywords: cll cnf2024 hsp90 inhibitor
changes of angle kappa after implantation of multifocal intraocular lenses

Conditions: Cataract; Presbyopia

Summary: the purpose of this study is to evaluate possible changes of angle kappa after multifocal intraocular lens implantation. presumable influencing factors of postoperative visual axis shift (ie. biometric parameters of the eye) are investigated to determine the degree and direction of angle kappa alterations.

the purpose of this study is to evaluate changes of angle kappa after multifocal intraocular lens implantation. during cataract surgery medicontur bi-flex 677my iol and alcon acrysof restor sn6ad1 iol are implanted. optical biometry is carried out for iol calculation and to measure axial length and angle kappa. three months after surgery biometry is repeated, iol position and angle kappa are measured using scheimpflug-camera.

Eligibility criteria:
inclusion criteria: * patients with age related cataract and presbyopia exclusion criteria: * patients with previous ocular surgery, trauma, active ocular disease, poorly dilated pupils, or known zonular weakness and corneal astigmatism \>1.5 diopters were excluded from the study.

Keywords: multifocal intraocular lens, angle kappa, presbyopia
randomized trial of colonic stents as a bridge to surgery

Conditions: Colorectal Cancer; Intestinal Obstruction

Summary: the objective of this randomized controlled trial was to evaluate the role colonic self-expanding metal stent (sems) placement as a bridge to surgery in patients with acute malignant left-sided colonic obstruction. the study was designed to test the hypothesis that sems placement could be effectively and safely used in this group of patients to relieve colonic obstruction thereby allowing safe recovery and medical stabilization before proceeding to elective surgery


Eligibility criteria:
inclusion criteria: * acute intestinal obstruction secondary to left-sided colonic cancer exclusion criteria: * distal rectal cancers * patients with signs of peritonitis suggestive of bowel perforation

Keywords: colorectal cancer endoscopic stent intestinal obstruction laparoscopy
development of a personalized, psychosocial intervention for menopausal individuals with elevated dementia risk

Conditions: Menopausal; Dementia

Summary: by age 45, women's lifetime risk of dementia is estimated to be 1 in 5. two-thirds of people currently living with a dementia diagnosis are women, and-women make up the majority of carers for people with dementia. because women bear a larger burden of the dementia epidemic, they tend to be more fearful about dementia compared to men. women may be especially fearful during the menopause transition, which can impact cognition. these fears can cause significant psychological distress, functional impairment, and avoidance of help seeking. interventions that acknowledge women's fears and promote adaptive coping during the menopause transition are needed to combat dementia-related fear and its negative impacts. this project aims to develop, and pilot test a brief personalized, psychosocial intervention for middle-aged perimenopausal individuals with elevated dementia risk. the investigators will assess the intervention's acceptability and feasibility for use in this population. the project will be completed in three stages. first, the investigators will conduct focus groups to better understand individual fears about dementia, informational and decisional needs, and strategies to promote adaptive coping as they transition through menopause (case-only, single time point). second, the investigators will develop an intervention to meet the specific needs identified by the focus groups. intervention components will address multiple areas of women's health in midlife, including aspects of physical and psychological health, as well as functional health outcomes that have important and long-lasting life implications. finally, the investigators will conduct pilot testing to assess the acceptability and feasibility of the intervention (cohort, 3-week testing period). this project will deliver a novel psychosocial intervention that can provide middle-aged perimenopausal women with the information and practical skills that can help them manage their dementia-related fears and encourage adaptive coping behaviors. outputs from the project will serve as preliminary data for a fully powered randomized controlled trial.


Eligibility criteria:
inclusion criteria: * female sex at birth * aged between 40-58 years * late perimenopause or early post-menopause * elevated dementia risk characterized by first degree relative with diagnosis of alzheimer's disease or another dementia exclusion criteria: * diagnosis of mild cognitive impairment, alzheimer's or another dementia * diagnosis of other chronic illness or condition that affects cognition (e.g., axis i psychiatric disorders such as schizophrenia or mood disorders, neurological disorders such as stroke, cancer, traumatic brain injury) * inadequate vision or hearing to engage with intervention materials * unable or unwilling to provide informed consent * iatrogenic menopause (i.e., due to surgery)
"the effect of aerobic exercise and strength training on physical activity level, quality of life and anxiety-stress disorder in young adults with and without covid-19"

Conditions: COVID-19

Summary: the purpose of this study; to examine the effects of aerobic and strength training on physical activity level, quality of life and anxiety-stress disorder in young adults with and without covid-19. in this context, the study was planned by including 15 participants between the ages of 18-25 who had covid-19 and 15 who did not have covid-19. data were collected by applying the personal data form, ipaq (international physical activity form), sf-36 quality of life scale, coronavirus anxiety scale (ccs), respiratory function tests (pft), six minute walk test (6mwt). aerobic training and strengthening training were applied to people with and without covid-19 for 12 weeks. aerobic exercise (walking) was given for 40 minutes 5 days a week, with the target heart rate being 70% of the age-corrected maximum heart rate. strengthening exercises were applied to the upper (triceps, biceps, deltoid, pectorals) and lower (quadriceps, hamstring, gastrocnemius, tibialis anterior, hip adductors, hip flexors, hip extensors) extremities and back muscles (trapezius, latissimus dorsi) with theraband (resistance band). significance test of the difference between two means in comparing independent group differences when parametric test assumptions are met for statistical analysis in line with the data collected from the participants; when parametric test assumptions are not met, mann whitney u test is used to compare independent group differences, while when parametric test assumptions are met to examine dependent group differences, the significance test of the difference between the two spouses is used; when parametric test assumptions were not met, the wilcoxon paired two sample test was used. in all analyses, p \< .05 was considered statistically significant.


Eligibility criteria:
inclusion criteria: * volunteering to participate in the study, * able to communicate, without hearing and/or visual impairment, * being between the ages of 18-25 * not having a systemic disease * having had covid-19 in the last 6 months to be included in the study group exclusion criteria: * unable to communicate, hearing and/or visually impaired, * not being between the ages of 18-25 * having a systemic disease other than covid-19 infection, * having had covid-19 more than 6 months ago.

Keywords: aerobic exercise, strength training, pulmonary capacity
tsdcs and physical therapy after incomplete spinal cord injury

Conditions: Spinal Cord Injury

Summary: the aim of this study is to evaluate the effects of tsdcs combined with physical therapy on the recovery of motor function in adult patients with chronic incomplete spinal cord injury.

a randomized, sham-controlled, double-blinded and parallel group trial (10 therapeutic sessions). active or sham tsdcs will be combined with physical therapy to verify the improvement of motor function in patients with incomplete spinal cord injury. assessments will be performed before and after therapeutic sessions and at the 30-day follow-up after the intervention, through: (i) asia lower and upper extremities motor scale (lems and uems), (ii) asia impairment scale (ais), (iii) ashworth modified scale; (iv) the functional independence measure (scim-iii), and (v) the patient global impression of change scale - (pgics).

Eligibility criteria:
inclusion criteria: * clinical diagnosis of incomplete spinal cord injury by a neurologist * diagnosis time greater than 12 months exclusion criteria: * patients with additional current neurological diagnoses * presence of contraindications for tsdcs

Keywords: trans-spinal direct current stimulation physical therapy spinal cord injury motor function
treatment with rhinospray plus in patients with acute rhinitis in the everyday curative routine in hungary

Conditions: Rhinitis

Summary: multi-centre, open-label, prospective, uncontrolled, single-arm, non-interventional study (nis) with objective to collect and evaluate data concerning treatment with rhinospray plus in everyday curative routine treatment of acute rhinitis

study design: open, observational, single-arm, uncontrolled

Eligibility criteria:
inclusion criteria: 1. patients who (or in case of 6-18 years old whose legal representative) have signed the informed consent 2. male and female ambulatory outpatients being seen in a participating physicians office for routine care 3. patients with a clinical diagnosis of rhinitis acuta 4. patient having the cognitive and functional abilities for answering the symptom specific questions 5. patients having expressed the willingness to participate in this observational study 6. patients at and above the age of 6 7. rhinospray plus naive patients (patients who have not used rhinospray plus before) exclusion criteria: 1. uncooperative patients based on physicians judgement 2. patients with any conditions making the application of rhinospray plus contraindicated 3. patients currently enrolled in any clinical trial which requires a change in medication for their respiratory problems 4. withdraw of informed consent 5. pregnancy or breast-feeding as stated in the summary of product characteristic (smpc) 6. patients with clinical diagnosis of allergic rhinitis
inflammatory markers in blood and thrombus aspirated from patients with acute myocardial infarction with st-segment elevation

Conditions: Patients Admitted With the Diagnosis of ST-elevation Acute Coronary Syndrome

Summary: the prognostic value of inflammatory markers in acute coronary syndrome has been extensively demonstrated, however it is still unknown whether there is an association between circulating and local (thrombus) inflammatory molecules, and the subset of molecules that provide better prognostic information in patients with st-elevation acute coronary syndrome.


Eligibility criteria:
inclusion criteria: * they include patients of both sexes, without limits of age, with a diagnosis of stemi within 12 hours after the beginning of symptoms. st-elevation myocardial infarction was defined in the presence of symptoms consistent, persistent elevation (\> 20 min) st segment ≥ 1 mm in at least two contiguous leads or in the presence of left bundle branch block presumably new onset and cardiac troponin i elevation exclusion criteria: * injury significant common core of left coronary artery (stenosis greater than or equal to 50% of the vessel lumen). * pre-fibrinolysis percutaneous coronary intervention. * previous coronary bypass surgery. * thyrotoxicosis. * having an inflammatory systemic or local inflammatory process. * malignant neoplasm. * any disease that seriously compromise the prognosis and / or systemic inflammatory response generated. * no thrombotic material obtained in the thrombus or insufficient for performing biochemical determinations.

Keywords: myocardial infarction, inflammation, thrombus, coronary angioplasty.
rationale for cytogenetic risk stratification by imaging flow cytometry in multiple myeloma

Conditions: Multiple Myeloma

Summary: a pioneer study demonstrated a proof of concept for is-fish with the new isx technology. this state of the art technology has been recently acquired by the chu of amiens. in the present study the investigators want to establish a workflow for simultaneous immunostaining and characterization of fish cytogenetic pathological signals with the imaging flow cytometer isx, such as chromosomic gains, losses and translocations in multiple myeloma (mm). the gold standard technology for the detection of prognostic cytogenetic aberrations in mm is a fish analysis after bone marrow (bm) plasma cells sorting (pcs).2,3 in mm, plasma cells isolation is usually based on cd38 and/or cd138 expression. cytogenetic risk stratification is guided by the detection of 4 chromosomal aberrations: tp53 and cdkn2c deletions, cks1b gains and t(4;14) translocation. thanks to isx technology the investigators may avoid cumbersome task of cell sorting (outsourced service for our hospital) meanwhile measuring precisely and qualitatively aberrant fish signals on a large amount of cells.

in a first time (period of 6 months), the development will be performed on cd38 and/or cd138 expressing cell lines. regular fish protocols will be finely tuned to fit immunophenotyping and cells in suspension constraints needed in is-fish. in a second time, the protocol will be applied to mm bm. cells from bm aspiration will be processed and analysed on the isx in amiens. based on last years local activity, this step is expected to last 2 years, so as to be able to obtain 5 samples from patients harbouring of each prototypical cytogenetic aberration above described. inclusions will be guided by the results of pcs conducted before the first treatment initiation. finally the results will be compared with pcs.

Eligibility criteria:
inclusion criteria: * available bm samples from active mm patients followed in the chu of amiens will be selected on the basis of pcs analysis systematically performed before treatment initiation. * signed consent exclusion criteria: * \<5% plasma cells in bm. * pre-bone marrow autograft samples

Keywords: is-fish imaging flow cytometry multiple myeloma
safety and efficacy study of a new intermittent pneumatic compression device to treat patients with peripheral arterial disease (pad) stage ii

Conditions: Peripheral Arterial Disease

Summary: the purpose of this study is to evaluate the safety and efficacy of new intermittent pneumatic compression device on initial claudication distance in patients with peripheral arterial disease stage ii

patients with peripheral arterial disease (pad) suffer from symptoms such as intermittent claudication, limb and foot pain and tissue lesions, which are difficult to treat. in recent years, there have been reports demonstrating reduction of these symptoms by use of compressible sleeve devices. this clinical study aims at demonstrating the safety and effectiveness of this device in treating pad symptoms.

Eligibility criteria:
inclusion criteria: * male or female subject 18 to 90 years, of any race. * patients with proven peripheral arterial disease (pad) in doppler ultrasound and ankle-brachial pressure index (abpi ≤ 0.9 in one leg) * subject with stable (\>3 month) pad fontaine stage ii. * aortoiliac vessels with no significant hemodynamic disturbances , as confirmed by recent (\<30 days) clinical examination * subject has intermittent claudication and claudication pain of the calf * subject has stable intermittent claudication (\>3 month and not more than one year) with initial claudication distance not more than 250 meters, as determined by treadmill test (3.2 km/h, 10% grade) * subject willing to participate as evidenced by signing the written informed consent. * treatment with aspirin or clopidogrel for at least 7 days * willingness to undergo standardized walking exercise exclusion criteria: * ankle-brachial pressure index (abi) above 0.8 in both legs. in diabetic patients with no compressible arteries abi above 40 mm/hg of the higher pressure measured in both arms. * inability to walk * chronic respiratory insufficiency (severe obstructive or restrictive) * coronary artery disease with angina * stroke, myocardial infarction or other acute vascular events in the last 3 months * mild-severe congestive heart failure * degenerative or inflammatory hip, knee, ankle or foot joint lesions interfering with walking * spinal stenosis or disc lesions with lower limb motor sensory defects * leg trauma, limb or skin infection or edema * recent (6 months) abdominal, cardiothoracic, vascular or orthopedic (lower limb) surgery * subject after crural or pedal bypass surgery * subject with neuropathy * uncontrolled arterial hypertension * morbid obesity (bmi \>35.0) * need for concomitant medication with potential vascular activity * routinely use of pain relief medications (i.e. nsaids, narcotics etc) * expected weak compliance * subject requires surgical or endovascular intervention for pad * subject has known allergy to device components (sleeve fabric). * subject has medical conditions that may be worsened by concomitant use of the device (i.e. recent (1 year) deep vein thrombosis). * subject participates in any other clinical study at the same time

Keywords: peripheral arterial disease intermittent pneumatic compression treatment initial claudication