Kornimate/medical-research-clean huggingface dataset:
comparison between the axillary bilateral-breast approach (abba) and bilateral axillo-breast approach (baba) for robotic thyroidectomy

Conditions: Thyroid Papillary Carcinoma; Thyroidectomy

Summary: the purpose of this study is to compare the therapeutic effects between the axillary bilateral-breast approach (abba) and bilateral axillo-breast approach (baba) for robotic thyroidectomy.to explore the efficacy, safety, cosmetic results and clinical value by the two approaches.

although several reports on operative outcomes of the robotic technique have appeared, no prospective trials comparing the clinical results of between the axillary bilateral-breast approach (abba) and bilateral axillo-breast approach (baba) for robotic thyroidectomy have been described. the investigators therefore designed a prospective trial comparing outcomes, including surgical outcomes and patient satisfaction, between patients undergoing robotic and conventional open thyroidectomy.

Eligibility criteria:
inclusion criteria: 1. the initial surgery 2. preoperative needle aspiration biopsy of thyroid cancer, and the diameter of no more than 1cm, no lateral neck lymph node metastasis 3. the tumor is confined to the thyroid membrane, not invading trachea and recurrent laryngeal nerve 4. intraoperative frozen section diagnosis of thyroid cancer 5. the patient informed consent. exclusion criteria: 1. high-frequency ultrasound preoperative tumor diameter greater than 1cm, or lateral neck lymph node metastasis in patients 2. there had been a history of thyroid surgery or neck radiation therapy 3. pregnant or lactating women 4. with severe hashimoto's thyroiditis, thyroid volume greater than ii ° 5. coagulation disorders, hyperthyroidism or hypothyroidism patients 6. sternal goiter.

Keywords: robotic thyroidectomy robotic central neck dissection axillary bilateral-breast approach bilateral axillo-breast approach
visual outcome of vitrectomy after refractive surgery

Conditions: Retinal Detachment; Refractive Errors

Summary: results of retinal detachment surgery may be affected in cases with history of previous intraocular surgery.

pars-plana vitrectomy for management of retinal detachment has favorable visual outcome with early intervention and development of small gauge instruments, cases with previous refractive surgery may be affected by other factors that may change the final visual outcome. in this study, we aim to analyze the effect of refractive surgeries on the final visual outcome after vitrectomy for the management of retinal detachment.

Eligibility criteria:
inclusion criteria: * cases diagnosed with primary retinal detachment and prepared for pars-plana vitrectomy. * cases with previous history for refractive surgery were enrolled in refractive surgery group. exclusion criteria: * cases with corneal diseases or trauma that may affect the final visual outcome. * cases with other retinal diseases that may affect the final visual outcome as age related macular degenerations and diabetic eye disease.
prevalence and topography of adenomas in 40-49 year old patients with a family history of colon cancer

Conditions: Colorectal Cancer; Colon Polyps; Adenomatous Polyp of Colon

Summary: conflicting guideline recommendations for screening colonoscopy result due to scant data upon which to develop appropriate recommendations. no previous study has compared the prevalence of advanced adenomas or adenomas (any size) among 40-49 year old individuals with a first degree relative (fdr) with colorectal cancer (crc) versus 40-49 year old average risk individuals with no family history of crc. the purpose of this study is to determine the prevalence of colon adenomas in 40-49 year old individuals and identify risk factors associated with the presence of advanced adenomas. this data will provide evidence to determine appropriate colon cancer screening guidelines in 40-49 year old persons with a family history of colon polyps or colorectal cancer.


Eligibility criteria:
inclusion criteria: * 40-49 year old asymptomatic men and women referred for colorectal cancer screening with a family history of crc in a first degree relative; * 40-49 year old asymptomatic men and women referred for colorectal cancer screening with a family history of polyps in a first degree relative; * 40-49 year old men and women without a family history of crc or polyps in a first degree relative who are referred for colonoscopy to evaluate scant hematochezia characterized as red blood on toilet tissue after wiping or small droplets of blood on stool or in toilet water after evacuating stool, abdominal discomfort or altered bowel habits characterized as constipation or diarrhea. exclusion criteria: * personal history of iron deficiency anemia within six months of referral; * personal history of iron deficiency without anemia within six months of referral; * personal history of (+) fobt within one year of referral; * personal history of previous colonoscopy or barium enema within the past 10 years; * personal history of previous flexible sigmoidoscopy in the past 5 years; * personal history of adenoma, colorectal cancer, inflammatory bowel disease, hnpcc, or familial adenomatous polyposis (fap); * unintentional weight loss \> 10 lbs within the previous six months; * individuals with family history of crc and scant hematochezia; * inability to speak and read english.

Keywords: colorectal cancer
multi-media obesity prevention program for adolescents

Conditions: Physical Activity; Nutrition; Obesity Prevention

Summary: the objective of this project was to evaluate a population-based, computerized tailored intervention that addresses recommended guidelines for three target behaviors related to obesity risk: physical activity (at least 60 minutes on at least 5 days per week), fruit and vegetable consumption (at least 5 servings of fruits and vegetables each day), and limited tv viewing (2 hours or less of tv each day).


Eligibility criteria:
inclusion criteria: * english speaking * in the 9th, 10th, or 11th grade at baseline exclusion criteria: -
standard length catheters vs long catheters in peripheral vein cannulation.

Conditions: Complications

Summary: the long and short is a prospective, randomized, controlled, open label trial to test the complications of different device for peripheral vein cannulation, standard length (about 5 cm in length) and long catheter (about 12 cm in length), inserted with seldinger technique.

the trial will compare the main complications: infiltration rate, phlebitis rate, occlusion and/or dislocation rate, thrombosis rate, number of percutaneous sticks, successful cannulation. will be made for a cost analysis.

Eligibility criteria:
inclusion criteria: * adult patients * infusional therapy more than 72 hours exclusion criteria: * need for central venous catheter

Keywords: infiltration, phlebitis, occlusion, thrombosis
study to evaluate the safety and antiviral activity of inarigivir soproxil (formerly: gs-9992) plus tenofovir alafenamide (taf) for 12 weeks in adults with chronic hepatitis b (chb)

Conditions: Chronic Hepatitis B

Summary: the primary objectives of this study are to evaluate the safety and tolerability of the 12 week treatment regimens of inarigivir soproxil plus tenofovir alafenamide (taf) or commercially available nucleoside/nucleotide (nuc) in adults with chronic hepatitis b (chb), to evaluate the antiviral activity of 12 weeks of inarigivir soproxil plus taf versus taf alone in viremic chb participants (groups 1-3, 5), and to evaluate the antiviral activity of 12 weeks of inarigivir soproxil with commercially available nuc(s) in virally suppressed chb participants (group 4).


Eligibility criteria:
key inclusion criteria: * groups 1-3 and 5: * individuals not taking any prescribed hepatitis b virus (hbv) nuc treatment * group 4: * hbv deoxyribonucleic acid (dna) ≤ 20 iu/ml at screening by central lab. * have been on a commercially available hbv nuc treatment(s) key exclusion criteria: * co-infection with hepatitis c virus (hcv), human immunodeficiency virus (hiv), or hepatitis d virus (hdv). * extensive bridging fibrosis or cirrhosis * evidence of hepatocellular carcinoma on imaging * any history of, or current evidence of, clinical hepatic decompensation (e.g., ascites, encephalopathy or variceal hemorrhage). * chronic liver disease of a non-hbv etiology * current alcohol or substance abuse note: other protocol defined inclusion/exclusion criteria may apply.
inflammatory stress and periodontal tissue destruction

Conditions: Oxidative Stress; Inflammation

Summary: metabolic syndrome and periodontitis are diseases that lower the quality of life and their incidence rates are increasing. since both of these diseases are associated with systemic inflammation and insulin resistance, they may be comorbid. the aim of this study was to evaluate the effect of interleukin-20 (il-20) on periodontal destruction in individuals with metabolic syndrome while considering the relationship between metabolic syndrome and periodontitis. this study included a total of 80 individuals who were systemically and periodontally healthy (cg, n=20), were systemically healthy and had periodontitis (pg, n=20), had metabolic syndrome and were periodontally healthy (mg, n=20), or had both metabolic syndrome and periodontitis (mpg, n=20). gingival crevicular fluid (gcf) and serum samples were collected from all participants for biochemical analyses.


Eligibility criteria:
study groups were created based on the guidelines of the 2017 classification of periodontal diseases and the 2005 metabolic syndrome diagnostic criteria of the endocrinology and metabolic society of turkey inclusion criteria: * all participants were required to have at least 20 teeth and be between the ages of 20 and 65 years exclusion criteria: * smokers, patients who had used antibiotics or anti-inflammatory and antioxidant drugs in the last 6 months, patients who were pregnant or lactating, those who had cancer or autoimmune diseases, and those who had undergone any periodontal treatment in the last 6 months

Keywords: metabolic syndrome periodontitis interleukin-20
prevention of colorectal cancer through multiomics blood testing

Conditions: Colon Cancer; Rectal Cancer; Colon Neoplasm; Colon Diseases; Colon Lesion; Colon Polyp; Colorectal Cancer; Polyp; Adenoma; Rectal Diseases; Gastrointestinal Tract Cancers

Summary: the preempt crc study is a prospective multi-center observational study to validate a blood-based test for the early detection of colorectal cancer by collecting blood samples from average-risk participants who will undergo a routine screening colonoscopy.

freenome is using a type of artificial intelligence, called machine learning, to identify patterns of cell-free biomarkers in blood to detect cancer early. the purpose of this prospective multi-center observational study is to validate a blood-based test for the detection of colorectal cancer by collecting blood samples from average-risk participants who will undergo a routine screening colonoscopy.

Eligibility criteria:
key inclusion criteria 1. 45-85 years of age 2. willing to undergo a standard-of-care screening colonoscopy 3. able and willing to provide a blood sample 4. able and willing to sign informed consent key exclusion criteria 1. known hereditary gastrointestinal cancer syndrome (for example, hereditary non-polyposis crc syndrome (hnpcc) or lynch syndrome, or familial adenomatous polyposis (fap) 2. personal history 2.1 crc or colorectal adenoma 2.2 inflammatory bowel disease (ibd), including chronic ulcerative colitis (cuc) and crohn's disease (cd) 2.3 colonoscopy in the 9 years preceding enrollment 2.4 stool dna testing in the 2 years preceding enrollment 2.5 symptoms of lower gastrointestinal tract disease warranting colonoscopic evaluation 3. a medical condition which, in the opinion of the investigator, should preclude enrollment in the study 4. participated or currently participating in a clinical research study in which an experimental medication has been administered during the 60 days up to and including the date of providing informed consent or may be administered through the time of the colonoscopy

Keywords: artificial intelligence liquid biopsy blood test cancer cancer diagnostic genomics genomics test crc cancer screening cancer early detection test screening colonoscopy machine learning freenome test colorectal cancer (crc) colorectal cancer screening
empiric treatment for acute hiv in the ed

Conditions: Acute HIV Infection

Summary: an acceptance and feasibility study for immediate art initiation and storage of laboratory specimens for individuals with suspected acute hiv infection who are diagnosed in one of the 7 participating emergency rooms

individuals with suspected acute hiv infection willing to start immediate art treatment will be given the art regimen (bictegravir 50mg + tenofovir alafenamide 25 mg + emtricitabine 200 mg fixed dose combination) on the day of diagnosis. those patients beginning immediate art in the ed who are willing to have additional laboratory specimens drawn in the ed and become part of a cohort to receive art and have ongoing biological specimens obtained and will be followed for 48 weeks.

Eligibility criteria:
inclusion criteria: * suspected acute hiv infection * agree to start immediate art and to storage of laboratory specimens exclusion criteria: * known chronic hiv infection * severe renal or liver disease * drug allergy/hypersensitivity * prohibited medications * pregnancy * co-morbidity that the investigator feels would compromise safety, data interpretation, or achieving study objectives

Keywords: acute hiv infection emergency department antiretroviral therapy
be study of calcipotriene hydrate and betamethasone dipropionate topical suspension in the treatment of scalp psoriasis

Conditions: Scalp Psoriasis

Summary: this study will be conducted to evaluate the therapeutic bioequivalence of a test formulation of calcipotriene hydrate and betamethasone dipropionate topical suspension 0.005%/0.064% to the rld.

randomized, double-blind, placebo-controlled, multiple-site, parallel design, bioequivalence with clinical endpoints.

Eligibility criteria:
inclusion criteria: * male or non-pregnant, non-lactating female, at least 18 years of age. * female subjects of childbearing potential (excluding women who are or premenarchal, surgically sterilized or postmenopausal for at least 2 years). * a clinical diagnosis of stable (at least 6 months) scalp psoriasis involving at least 10% of the scalp and clinical signs of psoriasis vulgaris on trunk and/or limbs. * scalp psoriasis consistent with at least moderate disease severity (grade ≥ 3) using the physician's global assessment (pga) of disease severity. * plaque elevation of at least moderate severity (grade ≥ 3) at the scalp target lesion site using the psoriasis area severity index (pasi). the most severe lesion at baseline will be identified as the scalp target lesion. * agree to stop use of all other topical or systemic antipsoriatic treatments, corticosteroids, immunosuppressive drugs, calcium supplements and vitamin d supplements or vitamin d analogs at a dose \> 400 iu/day during the study. * currently in general good health and free from any clinically significant disease, other than scalp psoriasis and psoriasis vulgaris, that may interfere with the study evaluations. * willing and able to understand and comply with the requirements of the study, apply ip as instructed, attend required study visits, comply with study prohibitions, and be able to complete the study. exclusion criteria: * current diagnosis of unstable forms of psoriasis including guttate, erythrodermic, exfoliative or pustular psoriasis. * other inflammatory skin disease in the scalp that may confound the evaluation of the scalp psoriasis (eg, atopic dermatitis, contact dermatitis, tinea capitis). * history of hypersensitivity to any component of test or rld. * current or past history of hypercalcemia, hypercalciuria, vitamin d toxicity, severe renal insufficiency, or hepatic disorders.
hepatitis b vaccination through syringe exchange programs: a randomized, controlled trial of vaccination schedules

Conditions: Hepatitis B

Summary: the investigators seek to provide immunization for individuals who are at high risk of contracting hepatitis b virus (hbv) infection because of their illicit drug use. the investigators will be using the syringe exchange programs (seps) in hartford and bridgeport, ct and chicago, il to contact high risk individuals and refer them for vaccination. the primary purpose of the study is to compare the standard schedule of hepatitis b vaccination at 0, 1, and 6 months to an accelerated schedule of vaccination at 0, 1, and 2 months. the investigators hypothesize that the accelerated scheduling will result in improved completion rates without significant loss in vaccine efficacy.


Eligibility criteria:
inclusion criteria: * demonstrate evidence of recent injection drug use (injection stigmata), * 18 years of age or older, * screened for and found susceptible to hbv * able to provide informed consent. exclusion criteria: * evidence of intoxication that prevented provision of informed consent.

Keywords: hepatitis b vaccination syringe exchange programs injection drug users hepatitis b prevention through vaccination
safety and efficacy study of the sorin 3d annuloplasty ring for mitral repair

Conditions: Mitral Valve Regurgitation

Summary: the purpose of this study is to collect data on the effectiveness and clinical outcomes of the memo 3d annuloplasty ring as used for mitral valve repair.


Eligibility criteria:
inclusion criteria: * the subject is 18 years old or older * an annuloplasty ring is indicated for reinforcement of a dysfunctional or diseased native mitral valve according to the current medical practice for valvular repair at each site. * the subject is able to return for all follow-up evaluations of the study. exclusion criteria: * the subject or subject's legal representative is unwilling to sign the informed consent. * the subject is or will be participating in another medical device or drug clinical trial. * the subject is a minor, prisoner, institutionalized, or is unable to give informed consent. * the subject has a life expectance of less than 1 year.

Keywords: mitral valve regurgitation mitral valve disease mitral valve repair mitral valve dysfunction heart valve valve disease cardiac surgery
comparison between the use of the tensioner and standard surgical technique for ligament balancing of total knee prostheses

Conditions: Knee Injuries

Summary: the objective of the present study is to compare the post-operative laxity using stress radiographs and clinical scores in two groups of patients undergoing primary ps tka with identical prosthetic model performed in two specialized centers, of which one group implanted with standard technique and one group through the intraoperative use of the tensioner


Eligibility criteria:
inclusion criteria: * male and female subjects candidates for primary cemented total knee prosthesis model attune ps mobile plate depuy. * patients who possess all the psychophysical capabilities to be able to undergo the operation and all the check-ups with radiological tests included (e.g. all patients who are not willing to go to the institute for all the scheduled follow-up visits will be excluded) . * patients who have signed the "informed consent" approved by the ethics committee. * patients who are aged between 50-85. exclusion criteria: * social conditions that prevent participation in the study in all its phases (homeless patients, with restrictions on personal freedom, etc.) * patients suffering from deep venous insufficiency of the lower extremities or with a personal or family history of deep venous thrombosis or pulmonary embolism * patients with a history of erysipelas in the lower extremities * patients suffering from neurological or psycho-cognitive disorders * patients suffering from post-traumatic arthrosis * patients who have already undergone prosthetic surgery and/or arthrodesis at the level of a lower limb joint * patients with axial knee deformities \>15° * pregnant female patients * patients with rheumatic diseases

Keywords: knee prosthesis prosthesis knee
mentalization-based training for adolescents with conduct disorder (mbt-cd)

Conditions: Conduct Disorder

Summary: a feasibility and pilot trial to investigate the feasibility of a newly manualized psychotherapy "mentalization-based training for adolescents with conduct disorder (mbt-cd)"

background: conduct disorder is a severe and complex mental disorder with the highest incidence in adolescence. previous studies have shown that family-oriented interventions are effective in the treatment of conduct disorder. however, most therapies focus rather on symptom management and less on etiological causes without inclusion of the family in the therapeutic process. previous research has linked specific symptoms of conduct disorder with deficits in mentalization ability. mentalization is the ability to perceive one's own and other's behavior as the product of affective and cognitive mental states. low or missing mentalization abilities are regarded as a risk factor for the development and chronification of conduct disorder. aims: the study aims to investigate the feasibility of a newly manualized psychotherapy "mentalization-based training for adolescents with conduct disorder (mbt-cd)" that strives to decrease symptoms associated with conduct disorder by increasing mentalization in adolescents and their families. methods: the study is feasibility and piolot trial, carried out in heidelberg (germany), and mainz (germany). adolescents aged between 11-18, who meet the dsm-5 criteria for conduct disorder will receive mbt-cd. times of measurement: t0 (screening), t1 (baseline, at the beginning of therapy), t2 (3 months after the beginning of therapy), t3 (at the end of therapy, after 6 months), t4 (follow-up, after 9 months).

Eligibility criteria:
inclusion criteria: * main diagnosis conduct disorder (dsm-5 312.81,312.82) * written informed consent exclusion criteria: * acute substance dependence * sexual offenses * acute psychotic symptoms, early or early-onset schizophrenia * neurological impairments and low intelligence (iq \<80) * non-german-speaking * other clinical contra indication for outpatient psychotherapy (e.g. acute suicidality)

Keywords: mentalization-based treatment conduct disorder adolescents
text message safety behavior fading for social anxiety

Conditions: Social Anxiety

Summary: the current study aims to explore the efficacy of a text message based safety behavior fading intervention compared to an active control intervention.

safety behavior fading may be a viable standalone intervention for social anxiety. in the present trial, participants high in social anxiety will be randomized to either receive a daily checklist exercise aimed at eliminating (1) safety behaviors or (2) unhealthy behaviors. individuals randomly assigned to the safety behavior fading condition will receive instructions to decrease or eliminate their four most habitual social anxiety safety behaviors. in addition, they will receive daily reminders via text message to decrease these behaviors, along with a safety behavior monitoring checklist in which the participant indicates the extent to which they decreased and/or eliminated each safety behavior over the previous day. individuals randomly assigned to the control condition will receive similar text messages and a daily checklist to encourage fading of unhealthy behaviors. participants in both conditions will complete checklists for 28 days. after day 14 of treatment, participants will re-select their target safety behaviors or unhealthy behaviors, and will then be prompted to reduce these new behaviors for another 14 days.

Eligibility criteria:
inclusion criteria: * social phobia inventory score \>29 * stable psychotropic medications for 4 weeks prior to participation exclusion criteria: * currently participating in psychotherapy for social anxiety

Keywords: social anxiety safety behaviors intervention text-message