Kornimate/medical-research-clean huggingface dataset:
open label study to access flurpiridaz f18 in pet mpi verses spect mpi

Conditions: Coronary Artery Disease

Summary: the study will evaluate the use of flurpiridaz f18 injection in patients with cad to determine if the study drug in pet imaging is better than spect imaging currently used for this purpose.

the study will assess the diagnostic efficacy (sensitivity and specificity) of flurpiridaz f18 injection mpi in comparison with spect mpi in patients with known or suspected cad. six hundred and seventy-two evaluable patients will be enrolled and will undergo spect mpi and flurpiridaz f18 pet mpi. patients will be considered for enrollment if they are scheduled to undergo or have undergone prior ica without intervention (being either positive or negative for cad).

Eligibility criteria:
inclusion criteria: invasive coronary angiography men or women age 18 or older - see protocol for additional details exclusion criteria: women who are pregnant, lactating, or of child bearing potential who are not practicing birth control unstable cardiac status history of coronary artery bypass graft history of pci within the past six months see protocol for additional details

Keywords: flurpiridaz f18 injection positron emission tomography myocardial perfusion imaging single positron emission computed tomography coronary artery disease myocardia ischemia coronary disease heart diseases cardiovascular diseases arteriosclerosis arterial occlusive diseases vascular diseases
quality of life improvement in dry eye patients after intense pulsed light therapy compared to punctal plugs

Conditions: Evaporative Dry Eye

Summary: dry eye disease (ded) is a widely spread disorder of tears and ocular surface affecting hundreds of millions around the world. manifestations resulting from moderate to severe ded have significant effects on the patient's quality of life (qol). these patients may suffer pain, role limitation, sleep disorders, anxiety, and depression. qol affection may be comparable to serious illnesses such as renal failure, angina, and disabling fractures. evaporative form is the commonest form of ded and it is mainly caused by meibomian glands dysfunction (mgd). the usual traditional treatment options for mgd include warm compresses, expression of meibomian glands (mg), anti-inflammatory drugs, and lubricant eye drops. in many instances, the traditional treatment with artificial tears is not effective. non-pharmacological intervention such as punctal occlusion was advocated in these patients. punctal plugs are designed to block lacrimal drainage, which helps in the preservation of lubricant drops, improving the tear film quantitively and qualitatively. intense pulsed light therapy (ipl) is another option that has been used by many investigators for the treatment of evaporative dry eye due to mgd safely and effectively. this study was conducted to compare the improvement of patients' qol after treatment of severe to moderate evaporative ded with ipl therapy versus silicone punctal plug insertion. the study included 30 patients with severe to moderate evaporative dry eye secondary to mgd. the effect of ded on patients' qol was evaluated with the aid of ocular surface disease index (osdi) questionnaire. fifteen patients were treated with ipl therapy. the treatment consisted of 3 sessions, with 15 days between the first and second sessions, and 30 days between the second and third sessions. and 15 patients were treated by silicone punctal plug insertion. after the completion of treatment, the improvement of patients' qol was evaluated by osdi questionnaire. the results of both treatments were compared.


Eligibility criteria:
inclusion criteria: * mgd patients with moderate to severe evaporative dry eye. * patients older than 18 years old. exclusion criteria: * patients with dry eye due to auto-immune disorders. e.g.: sjogren syndrome. * patients with conjunctival cicatrizing diseases. e.g.: ocular cicatricial pimphegoid. * patients with mild dry eye.

Keywords: dry eye mgd ipl therapy punctal plugs
matching glaucoma with impaired cognition

Conditions: Morbidity of Primary Open Angle Glaucoma

Summary: glaucoma is the leading cause of irreversible blindness in the world. the current study is designed to find the underlying relationship between impairment of topological perception and incidence of glaucoma.

glaucoma is currently the leading cause of irreversible blindness in the world. it has been a difficult task for ophthalmologists and researchers to diagnose glaucoma, especially in early stage. at present, glaucoma diagnosis mainly relies on oct and visual field test, which have relatively low sensitivity and specificity at the early stage of glaucoma. previous studies mainly focused on ocular manifestation of glaucoma. however, there was evidence that abnormalities of visual pathway also existed in patients with glaucoma, indicating cerebral cognitive defects may also be involved in glaucoma development. thus, the current study was designed, in which subjects at high-risk of developing glaucoma are separated into two group based on test results of topological perception. after five years' follow-up, morbidity of primary open-angle glaucoma would be compared between groups to see if there was any relationship between impaired cognitive function and incidence of glaucoma.

Eligibility criteria:
inclusion criteria: 1. aged between 18-55; 2. best corrected visual acuity ≥ 0.6, capable of completing routine glaucoma examinations; 3. spherical equivalent \< 3d； 4. no history of other ocular diseases (except mild cataract), including diabetic retinopathy, age-related macular degeneration, optical neuropathy, eye trauma, strabismus, nystagmus, severe dry eye, ptosis of the eyelid, etc. exclusion criteria: 1. unable or unwilling to sign informed consent, or cannot comply with the study protocol 2. diagnosed with any kind of glaucoma (based on visual field and oct, etc) or primary angle-closure diseases(primary angle closure suspect and primary angle closure, based on gonioscopy and ubm examination); 3. history of ocular surgeries or laser; 4. diagnosed with specific neurologic diseases or psychiatric disorders: parkinson's disease, alzheimer's disease, anxiety, depression, schizophrenia, etc.(based on scale screening) 5. with severe systemic diseases: diabetes mellitus, hypertension(systolic pressure≥160mmhg or diastolic pressure≥100mmhg ), heart diseases, kidney diseases, rheumatological disorder, digestive diseases, cancer, etc. 6. pregnancy or lactation

Keywords: topological perception glaucoma
northern board beet breathlessness trial

Conditions: Exercise Tolerance (Measured in Minutes)

Summary: hypothesis: beetroot juice increases the exercise tolerance of patients with chronic lung disease. using the already established pulmonary rehabilitation model, we aim to split the group of 8 into 2 groups, each group taking 500ml of beetroot juice 24 hours before there class on alternate (differing) weeks to see if it improves their overall exercise tolerance.


Eligibility criteria:
inclusion criteria: * already planned to attend the pulmonary rehabilitation class exclusion criteria: * angina prescribed regular nitrates, a resting heart rate \>100bpm, a resting blood pressure \<110 systolic, postural hypotension, prescribed pde5 inhibitors.
functional and neurochemical correlates of treatment response in major depressive disorder

Conditions: Treatment-Resistant Depression

Summary: this is an ancillary study to a clinical trial that is being conducted at massachusetts general hospital. investigators at mgh are conducting a clinical trial to test the efficacy of ziprasidone together with escitalopram for treatment-resistant depression (nct00633399). this observational study will involve magnetic resonance scans to examine brain chemistry (neurotransmitter levels), brain activity, and functional connections between brain regions before and after participating in the trial. the neurotransmitters of interest are glutamate, glutamine, and gaba. comparisons will be made between individuals who receive ziprasidone and individuals who receive an inactive placebo. differences between participants who respond to standard antidepressants and those who require additional medication will also be examined. all participants will have a baseline magnetic resonance scan before starting medication. the second scan will be after 8 weeks of escitalopram treatment for those who respond or following 8 weeks of escitalopram plus ziaprasidone or placebo (16 weeks after starting) for those who do not respond to escitalopram alone. participants will complete standard rating scales for depression at each visit.


Eligibility criteria:
inclusion criteria: * aged 18-65 * meets dsm-iv criteria for major depressive disorder * meets eligibility criteria for clinical trial of ziprasidone augmentation of escitalopram * capable of providing informed consent exclusion criteria: * meets exclusion criteria for augmentation clinical trial protocol * pregnancy or unwillingness to avoid pregnancy during trial * current or past psychosis or bipolar disorder * substance abuse or dependence in the past six months * clinically significant suicidality * unstable cardiovascular, hepatic, renal, respiratory, endocrine, neurological, or hematological disease or uncontrolled seizures * use of a concomitant medication that acts on glutamate or gaba neurotransmission * contraindication to magnetic resonance imaging (metal implant or device, occupational metal exposure, significant claustrophobia)

Keywords: magnetic resonance imaging magnetic resonance spectroscopy depression escitalopram selective serotonin reuptake inhibitor treatment-resistant depression ziprasidone
american breast laser ablation therapy evaluation

Conditions: Benign Breast Conditions; Breast Fibroadenomas

Summary: the purpose of this patient tracking program is to monitor long term safety and effectiveness of the novilase™ device and method in real world application.

ablate is a prospective, observational multi-center tracking database which will evaluate clinical outcomes from patients undergoing novilase for benign breast conditions (i.e. fibroadenomas, papillomas, etc). data captured will assess the potential advantages and disadvantages of the procedure as compared with lumpectomy. tumor characteristics, equipment used, complications, patient satisfaction and cosmesis ratings will also be tracked.

Eligibility criteria:
inclusion criteria: * diagnosis confirmed by needle core biopsy * tumors detected either by physical exam or imaging * tumors do not exceed 2 cm in diameter and measure at least 0.5 cm away from the skin and chest wall * single, multiple and/or bilateral tumors * patient has given consent prior to being treated with novilase™ exclusion criteria: * patient is pregnant or lactating * hypercellularity suggestive of phyllodes * atypia * equivocal pathology report (e.g., discordance between radiographic and microscopic results) * fibroadenomas with stromal solidarity

Keywords: fibroadenomas papillomas breast minimally invasive interstitial laser therapy laser ablation benign non-cancerous breast lesion breast tumor
diffusion-tensor imaging in brain tumors evaluation

Conditions: Diffusion Tensor Imaging; Tractography; MRI

Summary: primary and secondary brain tumors are challenging pathologies regarding diagnosis and treatment. mri is widely used in the imaging evaluation and surgical planning, due to its spatial resolution and ability of tissular characterization. in this study patients with suspected brain tumors, confirmed by routine mri evaluation (t1, t2, t2\*, flair, t1 with contrast sequences) will undergo dwi and dti evaluation. by analyzing collected data from mri evaluation and patient records regarding surgical and histopathological data our aim is to investigate derived imaging biomarkers with impact in the surgical planning and rehabilitation of the patients.


Eligibility criteria:
inclusion criteria: * brain tumors confirmed by routine mri evaluation * surgical treatment with histopathological diagnosis exclusion criteria: * mri contraindications * past or present neurological or neurosurgical condition, beside the tumor * pregnancy
validation of nexfin cardiac output in elderly patients with hip fracture

Conditions: Hip Fractures; Anesthesia

Summary: measurement of how much blood the heart pumps may be useful in guiding how much intravenous fluid to give patients during surgery. the current monitors either require special drips (arterial and/or central lines) or a probe inserted into the oesophagus (food pipe) which may limit their use. newer monitors are available which are completely non-invasive and seem to work well in younger patients. patients with hip fracture are elderly and frail. the investigators wish to see whether the newer non-invasive monitor works well enough compared to the current monitors in this group of patients. if it does this may allow more of these patients to be monitored in this way.

the investigators wish to compare the accuracy of the newer, non-invasive monitor (nexfin) against a more established minimally invasive monitor (lidco). the lidco has a calibration system which allows the absolute accuracy of the nexfin to be established.

Eligibility criteria:
inclusion criteria: * aged over 80 * able to give their own informed consent exclusion criteria: * severe valvular heart disease * taking lithium

Keywords: cardiac output stroke volume
short-course radiotherapy combined with capeox and pd-1 inhibitor after local excision for high-risk early rectal cancer (torch-le)

Conditions: Rectal Cancer

Summary: this is a single arm phase ii study to explore the 3y lrfs and safety for high-risk early rectal cancer after local excision with short-course radiotherapy and chemo-immunotherapy.

a total of 60 patients with high-risk pathologic stage pt1 or pt2 cancer after local excision but refused radical surgery will be included. eligibility criteria include a histological diagnosis of adenocarcinoma located ≤7 cm from the anal verge, pt1 after local excision of the primary rectal cancer, with one of the high-risk features including margin positivity/very close margin (\ 1 mm or sm3 invasion (submucosal invasion to the lower third of the submucosal level), high grade or poorly differentiated, lymphovascular invasion, perineural invasion, tumour budding, or pt2 tumor. they will receive 5\*5gy short-course radiotherapy, followed by 4 cycles of capecitabine plus oxaliplatin (capox) chemotherapy and pd-1 antibody.

Eligibility criteria:
inclusion criteria: 1. age 18-75 years old, female and male 2. pathological confirmed adenocarcinoma 3. the distance from anal verge ≤ 7 cm 4. pt1 after local excision of the primary rectal cancer, with at least one of the high-risk features including margin positivity/very close margin (\ 1 mm or sm3 invasion (submucosal invasion to the lower third of the submucosal level), high grade or poorly differentiated, lymphovascular invasion, perineural invasion, tumour budding, or pt2 tumor. 5. refuse radical surgery 6. without pelvic or distance metastases 7. kps \>=70 8. with good compliance 9. microsatellite repair status is mss/pmmr 10. without previous anti-cancer therapy or immunotherapy 11. signed the inform consent exclusion criteria: 1. pregnancy or breast-feeding women 2. pathological confirmed signet ring cell carcinoma 3. history of other malignancies within 5 years 4. serious medical illness, such as severe mental disorders, cardiac disease, uncontrolled infection, etc. 5. immunodeficiency disease or long-term using of immunosuppressive agents 6. baseline blood and biochemical indicators do not meet the following criteria: neutrophils≥1.5×10\^9/l, hb≥90g/l, plt≥100×10\^9/l, alt/ast ≤2.5 uln, cr≤ 1 uln 7. dpd deficiency 8. allergic to any component of the therapy

Keywords: early rectal cancer high risk local excision radiation pd-1 inhibitor chemotherapy
acute effect of static stretching and muscle warming on the functional performance of college volleyball athletes

Conditions: Neuromuscular Manifestations

Summary: the purpose of this study is analyze the effects of static stretching and active warm up, isolated and associated, in functional performance of the lower limbs in college volleyball athletes. study hypothesis: h0: the stretching and / or warm up, alone or in combination, do not alter the functional performance of volleyball players. h1: the stretching and / or warm up, alone or in combination, alter the functional performance of volleyball players.

this is a cross-over study containing 11 volleyball athletes randomly divided into 5 groups: control (c), warming-up (gaq), stretching (gal), warming-up and stretching (gaqal), stretching and warming-up (galaq). all subjects underwent the evaluation measures of functional performance that were conducted pre and post intervention.

Eligibility criteria:
inclusion criteria: 1. being male; 2. were aged between 18 and 28 years of age; 3. no previous history of orthopedic disorders, rheumatic disorders, cardiovascular, metabolic and / or vestibular and neurological disorders that prevent them from participating in the study dysfunctions; 4. no history of injury, trauma or disease in the lower limbs in the last six months, without surgery; 5. participate in the university selection ufrn; 6. training time display mode in the above two years with a frequency of at least three times a week. exclusion criteria: 1. presence of injury during the survey period; 2. not conduct evaluative and intervention procedures; 3. waiver to participate.

Keywords: exercise muscle stretching electromyography
to demonstrate the relative bioavailability of diclofenac sodium 50 mg enteric-coated tablets

Conditions: Inflammation

Summary: to demonstrate the relative bioavailability of diclofenac sodium 50 mg enteric-coated tablets.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal finding on physical exam, medical history, or clinical laboratory results on screening. exclusion criteria: * positive test results for hiv or hepatitis b or c. * treatment for drug or alcohol dependence.

Keywords: anti-inflammatory
reproductive hormones during sustained administration of kisspeptin

Conditions: Fertility Disorders; Hypothalamic Dysfunction

Summary: we want to find out what happens to reproductive hormone levels; luteinising hormone (lh), follicle stimulating hormone (fsh), testosterone and oestradiol when kisspeptin is administered to people for a period of 8 days each month, using either placebo (saline) or kisspeptin in doses of 0.1, 0.3 or 1.0 nmol/kg/hour.

participants will be invited to have an initial baseline study to look at the hormone levels at regular intervals over the course of a day (8hours). following this, on a different day, volunteers will have an infusion of kisspeptin, which will be administered by a small pump to deliver the hormone into subcutaneous tissue (fatty tissue just below the skin surface). on day 1 of the pump infusion there will be another day of regular blood sampling for 8 hours. after this the kisspeptin pump will continue and the participants will return to the research unit on day 3 for a review and a single blood test. on day 5 the participants will have a review, a blood test and the kisspeptin pump will be changed. kisspeptin infusion will continue and on day 8 the participant will return for another 8 hour study. at the end of this the kisspeptin pump will be removed. the above will be repeated using either placebo (saline) or kisspeptin in doses of 0.1, 0.3 or 1.0 nmol/kg/hour during the early follicular phase of 4 separate menstrual cycles.

Eligibility criteria:
inclusion criteria: * aged 18-60 years old * ability to give informed consent * secondary hypogonadism (or healthy participant) exclusion criteria: * anaemia * medical problems such as severe heart, kidney or liver disease * blood donation in the last three months or intention to donate blood within 3 months of the end of the study * needle phobia * poor venous access * active psychiatric illness * severe allergies * impaired ability to provide full consent to take part in the study * current alcohol or illicit drug dependence * current pregnancy or breast feeding * plans to conceive within 3 months of starting the study (barrier contraception must be used during and for 3 months after the end of the study) * arthritis or any impairment of hand coordination which would preclude using a hormone pump

Keywords: infertility kisspeptin reproductive hormones
adjustment exploratory protocols and functional evaluation of new non invasive devices in patient volunteers

Conditions: Neurological Diseases

Summary: parameters, sequences or paradigms optimisation in view of data quality and relevancy improvement.

various tests are needed for methodological optimization of the several devices (per-operative mri, meg, eeg, spect-ct, motor platform) of the technological platform.

Eligibility criteria:
inclusion criteria: * volunteers patient * male or female aged over 18 years * registered in the french social security scheme * signed informed consent exclusion criteria: * contraindication to magnetoencephalography (meg) and/or electroencephalography (eeg) * contraindication to magnetic resonance imaging (mri) * all categories of protected persons
the association between areca-nut chewing habit and metabolic syndrome

Conditions: Oral and Esophageal Cancer; Metabolic Syndrome.

Summary: the purpose of this study is going to determine the odds ratio of metabolic syndrome (ms), the habit of areca nut chewing, antioxidant, and inflammatory status in oral and esophageal patients. the current study was designed as a case-control study. patients proved to be oral and esophageal cancer and had the habit of areca nut chewing are defined as case group. patients proved to be oral and esophageal cancer and did not have the habit of areca nut chewing are defined as control group. the participants' age, blood pressures, and smoking habits will be recorded. body weight, height, waist, and hip circumferences will be measured. fasting venous blood samples will be obtained to determine hematological parameters \[i.e., serum creatinine, total cholesterol, triacylglycerol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, malondialdehyde, superoxide dismutase, glutathione peroxidase, catalase, and inflammatory markers (c-reactive protein, tumor necrosis factor-alpha, and interleukin-6)\]. logistic regression analyses are going to perform to examine the relationship between areca nut chewing and ms in this population. if we can make sure the relationship between areca nut chewing and ms, the clinicians and nutritionists can teach people to quit areca nut chewing in order to avoid the possibility of developing metabolic syndrome and cardiovascular disease.


Eligibility criteria:
inclusion criteria: * patients proved to be oral and esophageal cancer will be recruited. exclusion criteria: * subjects with diabetes mellitus, liver, renal diseases, or undergoing statin therapy. * taking antioxidant vitamins supplements.

Keywords: nut chewing