Kornimate/medical-research-clean huggingface dataset:
the effect of acceptance and commitment therapy in patients with chronic renal failure

Conditions: Kidney Failure, Chronic

Summary: psychological flexibility, life satisfaction and adaptation to the disease of individuals with chronic kidney disease were increased with psychoeducation based on acceptance and commitment therapy to be given to individuals with chronic kidney disease.

chronic renal failure is a condition that affects the kidneys and has long-term consequences for physical, psychological, and social well-being. it reduces quality of life, productivity, and independence, leading to increased costs and the need for care. in order to ensure treatment compliance and maintain living standards, it is important to enhance individuals' readiness for treatment. while there are psychological intervention studies during the treatment process, there are few studies that focus on psychological readiness before dialysis. this study highlights acceptance and determination-based approaches to help individuals become aware of their feelings and thoughts and accept them, minimizing resistance to treatment and improving treatment compliance. by managing negative emotions and thoughts towards the treatment, this study aims to increase disease compliance, provide psychological support during pre-dialysis trainings, diversify the use of acceptance and commitment therapy-based approaches, and promote psychosocial support in chronic diseases in psychiatric nursing practices.

Eligibility criteria:
inclusion criteria: * acceptance to participate in the research * diagnosis of ckd stage 4-5 * gfr below 29ml/min/1.72m2 * 18 years of age and over * being literate * no barriers to verbal communication * no psychiatric treatment exclusion criteria: * receiving haemodialysis and peritoneal dialysis treatment, * pregnancy * the presence of a psychiatric disorder requiring treatment, * individuals with transplantation and rejection transplantation

Keywords: kidney failure, chronic acceptance and commitment therapy psychiatric nursing psychological flexibility
liquid biopsy based multiomics study for colorectal cancer early screening

Conditions: Colorectal Cancer; Adenomatous Polyps; Adenoma; Advanced Adenoma

Summary: the primary objective is to determine the diagnostic sensitivity and specificity of the newly developed liquid biopsy based multiomics colorectal cancer (crc) screening test (crc-appareo) for detecting advanced neoplasia (including colorectal cancer and advanced adenomas) in high risk patients and patients with confirmed crc, using colonoscopy as the reference method. the secondary objective is to compare the screening performance of the multiomics colorectal cancer (crc) screening test with commercially available fit (fecal immunochemical test) assay in detecting advanced neoplasia.

the study will be carried out in 5 hospitals throughout china. patients who are at high risk of developing crc or confirmed crc and willing to conduct colonoscopy examination will be asked to collect blood prior to bowl preparation for multiomics crc screening test which using reduced representation bisulfite sequencing (rrbs) technology to obtain multidimensional variation information on cell-free dna (cfdna) methylation, end sequence, fragment size distribution, and copy number variation in the blood, and integrate analysis through machine learning algorithms to accurately assess the risk of colorectal cancer and advanced adenoma. and will be asked to collect stool sample for commercially available fit assay. colonoscopy and histopathologic examination are used as reference. the diagnosis information of each sample was blind to the participants who conduct the multiomics profiling, as well as the informatics who perform the integrate analysis.

Eligibility criteria:
inclusion criteria: willing to provide written consent able to provide blood and stool samples for high risk crc screening group: scheduled for colonoscopy voluntarily or by physician prescription crc high risk profile as defined below: history of fit positivity family history of crc any of two of the following clinical symptoms: chronic constipation/diarrhea, stool with mucous, chronic appendicitis, chronic bilary track diseases, mental stress for crc group: confirmed crc patients no prior treatment with chemotherapy, radiotherapy, and prior to any surgical procedures exclusion criteria: unwilling to provide blood samples fap (familial adenomatous polyposis), crohn's disease, ulcerative colitis prior history of colonoscopy within the past 5 years and removal of lesions history of crc other conditions deemed not suited for the study by investigators
neural network to calculate morphology of the cleft palate to reduce cleft lip and palate treatment burden.

Conditions: Cleft Palate; Orofacial Cleft

Summary: this study is to develop a neural network to compute palatal three dimensional (3d) geometry by using routinely taken intraoral/palatal photographs and palatal casts of infants with cleft lip and palate deformity for reducing cleft lip and palate treatment burden. data of palatal casts and palatal images of cleft patients routinely treated at the university hospital basel will be analyzed.the collection of large data helps in developing a neural network that will allow the computation of the 3d geometry from single photographs.


Eligibility criteria:
inclusion criteria: * patients with cleft lip and palate malformation with available routinely performed plaster cast model from palatal impressions, intraoral scans from the palate and corresponding images of the cleft palate (1970 till 2025) exclusion criteria: * existence of a documented rejection

Keywords: cleft lip neural network palatal plate therapy palatal 3d geometry palatal shape reconstruction
efficacy of melatonin in burning mouth syndrome (bms)

Conditions: Burning Mouth Syndrome

Summary: the purpose of this study is to determine whether melatonin is effective in the treatment of burning mouth syndrome (bms).

this is a crossover trial involving a total of 20 patients with burning mouth syndrome, considered a chronic neuropathic pain. in two consecutive treatment periods, both 8 week long, each patient receives externally indistinguishable capsules (placebo or melatonin). a 4 weeks wash-out period is applied, between these two periods. the capsules contain either placebo or 3 mg-melatonin (4 time/day for a total of 12 mg/day of melatonin). the primary endpoint is the change in pain intensity at the end of each treatment period, measured using vas, verbal intensity score and nrs, as well as number of oral sites affected by the burning sensation. furthermore, data from quality of life, anxiety and sleep questionnaires are collected (sf-36, ham-a, ess, mos). adverse effects are carefully recorded as well as blood samples, in order to measure serum melatonin levels during the trial.

Eligibility criteria:
inclusion criteria: * patients over 18 yrs suffering from burning mouth syndrome exclusion criteria: * epilepsy * pregnancy * concomitant treatment with melatonin * concomitant anticoagulants * night time working persons

Keywords: burning mouth syndrome treatment oral chronic pain
airway clearance therapy on hyperpolarized 129xenon and mri

Conditions: Cystic Fibrosis

Summary: this is an observational cohort study building on an existing protocol at our institution recruiting cf patients who are 6-21 years old with one or two copies of the f508del cftr mutation. that existing protocol seeks to enroll a total of 38 subjects; it includes three to four (three scheduled, with a fourth optional) study visits, with spirometry, lci, ute mri, and 129xe mri being performed at each visit. this present study will utilize existing study visits for the nhlbi study, with a sub-set of 20 subjects opting-in to have all of the procedures performed twice, with an intervening act, during one of their study visits.

this is an observational cohort study building on an existing protocol at our institution recruiting cf patients who are 6-21 years old with one or two copies of the f508del cftr mutation. the existing protocol is funded by the nhlbi under r01-11863962 (pis woods, clancy, and hereafter referred to as "the nhlbi study" for simplicity), and seeks to enroll a total of 38 subjects; it includes three to four (three scheduled, with a fourth optional) study visits, with spirometry, lci, ute mri, and 129xe mri being performed at each visit. this present study will utilize existing study visits for the nhlbi study, with patients opting-in to have all of the procedures performed twice, with an intervening act, during one their study visits. the target enrollment is 20 subjects. airway clearance therapy (act) is used for treating cystic fibrosis (cf). it is known to impact measures of lung function, and while an increasing number of lung function measures are used in clinical trials, there has been no direct comparison of the effects of act across the different modalities. this study is actively investigating the relationship between different measures of lung function, comparing a spirometric measure (fev1 percent-predicted) with measures of whole-lung ventilation (lung clearance index, or lci) and regional assessments of both structure (with ultra-short echo time magnetic resonance imaging, or ute mri) and function (with hyperpolarized xenon, or 129xe, mri). performing these assessments on cf patients will help to elucidate the relative sensitivity of each measure to intra-individual changes within the lung and will help guide the selection of lung function measures in future studies.

Eligibility criteria:
inclusion criteria: * male or female between the ages of 6 through 21 years * cftr genotypes as specified in nhlbi study: two copies of the f508del cftr mutation, or two non-functional cftr mutations with one of them being f508del cftr mutation • able to perform acceptable and repeatable spirometry exclusion criteria: * fev1 percent predicted of \<60% * standard mri exclusions (metal implants, claustrophobia) * pregnancy
pericapsular nerve group block: an imaging study for determination of the spread of the injectate using 3-d ct scan

Conditions: Post Operative Pain; Mechanisms of Analgesia

Summary: over the last 20 years, different interventional regional analgesia techniques have been proposed to treat pain after hip surgeries. the most commonly used techniques are the fascia iliaca and femoral nerve blocks, resulting in reduced pain scores, opioid-sparing effects, and opioid-related adverse effects. however, these interventional analgesia techniques result in a motor block and muscle weakness of the quadriceps muscle, impeding early ambulation and rehabilitation. recently, the pericapsular nerve group (peng) block has been proposed as an effective choice for analgesia after hip surgeries while sparing the motor function of the lower extremities. the aim of this technique is to inject local anesthetic to target the more distal sensory branches innervating the anterior aspect of the hip joint.

ten patients scheduled for hip surgery were included after ethical committee approval and informed consent were obtained. preoperatively, patients received an ultrasound-guided pericapsular nerve group block. the injections were performed preoperatively using a canon us applio 700 with a linear transducer (14 to 6 mhz), and a 21-gauge, 80 mm stimulating needle (sonoplex stim, pajunk ® ️ gmbh, germany). after confirmation of the correct needle tip position with 2 ml of sodium chloride 0.9%, 20 ml of injectate containing 18 ml ropivacaine 0.5% with 2 ml of radiopaque contrast (iomeron 300: 61.24% w/v of iomeprol equivalent to 30% iodine or 300 mg iodine/ml (bracco uk limited)) was injected. after surgery, high-definition ct scans (siemens) were obtained to determine the distribution patterns of the injectates.

Eligibility criteria:
inclusion criteria: 1. an indication for peng blocks for postoperative pain management 2. american society of anesthesiologists (asa) physical status i or ii 3. at least 18 years old, and able to understand the purpose and risks of the study exclusion criteria: 1. pregnancy 2. body mass index above 35 kg/m2 3. hepatic or renal insufficiency 4. history of allergic or adverse reactions to local anesthetics or contrast agents.
tripeptide/hexapeptide topical and hybrid laser treatment for acne scarring

Conditions: Acne Scars - Mixed Atrophic and Hypertrophic

Summary: to evaluate the efficacy of a tripeptide/hexapeptide topical (alastin regenerating skin nectar with trihex technology®) in wound healing and scar reduction following erbium:yag hybrid resurfacing laser for acne scarring compared to the standard of post-procedure care consisting of a bland moisturizer.


Eligibility criteria:
inclusion criteria: * male or females * age 18 and older * with evidence of grade ii-iii acne scars on the face (mild to moderate) as determined by the goodman \& baron qualitative global acne scar grading system exclusion criteria: * treatment to face with any energy device within 6 months * tanning within 7 days * dermabrasion or chemical peel within 3 months * current use of systemic retinoids * keloidal scaring in the treatment area * use of systemic steroids within 6 months * use of topical products with retinoid, alpha-hydroxyacid, salicylic acid, vitamin c or e within 14 days
the men's domestic abuse check-up engages adult men concerned about their abusive behavior and alcohol or drug use

Conditions: Domestic Violence; Substance Abuse

Summary: this research is a stage 1b developmental trial evaluating an intervention called "the men's domestic abuse check-up" with adult men abusing their intimate partners and also struggling with alcohol or drug use.

one hundred and forty adult men concerned about their substance use and behaviors toward intimate partners, recruited in washington state, will be enrolled in the trial. participants are recruited through print and radio ads. following a baseline assessment, participants are then randomly assigned to receive one of two interventions: * the experimental intervention is a two-session motivational enhancement treatment. a personalized feedback report, containing information from the participant's assessment as well as normative comparison data, is reviewed, with the counselor employing motivational interviewing strategies intended to impact study outcomes. * the comparison condition involves an educational brochure focusing on the legal, health and behavioral effects of intimate partner violence, substance abuse, and hiv risky behaviors. following the two interventions, participants are reassessed at 1 week, 1 month, and 4 months following either intervention.

Eligibility criteria:
inclusion criteria: * age (18 years and older) * gender (male) * self-reported abusive behaviors * concerned about alcohol or drug use exclusion criteria: * not fluent in english * they have a thought disorder that precludes full participation * they refuse to accept randomization to condition
fluorescence imaging on the da vinci surgical system for intra-operative near infrared imaging of the biliary tree (up to 2-weeks post-operatively)

Conditions: Gallbladder Disease; Biliary Colic; Gallstones

Summary: the investigators hypothesize that the da vinci fluorescence imaging vision system provides real-time endoscopic near infrared fluorescence imaging of the biliary anatomy as defined as identifying biliary vessels; either cystic duct, common hepatic duct (chd) or common bile duct (cbd). irradiation given to the patient during a classic cholangiography can be reduced.

up to 40 patients will be prospectively enrolled in this multi-centre (up to 5 centres) single arm study. after given consent, patients will undergo minimally invasive cholecystectomy with da vinci fluorescence imaging using indocynine green (icg) and near infra-red light (nir) to identify the surgically relevant anatomy of the biliary tree during this procedure. efficacy endpoints the efficacy of the da vinci fluorescence imaging vision system to identify biliary anatomy will be demonstrated by successful detection (90%) of one or more of the following biliary vessels: cystic duct, common hepatic duct (chd) or common bile duct (cbd). safety endpoints to observe and report peri-operative safety outcomes, including but not limited to incidence of adverse events and allergic reactions (rare according to the current knowledge and applications). safety endpoints will be met by affirming the safety profile of the procedure, compared to currently available literature.

Eligibility criteria:
inclusion criteria: * informed consent * ages of 18 to 80 years. * symptoms consistent with gallbladder disease including biliary colic or chronic right upper quadrant pain. * ultrasound confirming gallstones exclusion criteria: * acute cholecystitis * biliary pancreatitis * suspicion of common bile duct stones. * pregnancy. * previous upper abdominal open surgeries. * severe lack of cooperation by patient due to psychological or severe systemic illness. * the presence of medical conditions contraindicating general anesthesia or standard surgical approaches. * subject has a previous history of adverse reaction or allergy to icg, iodine products (or excipient), shellfish or iodine dyes * surgery converted to non-robotic procedures, such as open surgery or laparoscopic surgery

Keywords: cholecystectomy chronic right upper quadrant pain
personalized home respiratory rehabilitation program for subjects with systemic sclerosis with early lung disease

Conditions: Systemic Sclerosis

Summary: systematic sclerosis (ssc) is a potentially severe disease characterized by various visceral involvements including lung. the investigators hypothesize that a respiratory rehabilitation program specifically designed for people with systematic sclerosis with early lung disease could help to decrease respiratory deficiencies, improve aerobic capacity and prevent activity limitations and participation restrictions. before testing the effectiveness of such a program, a pilot study is needed to assess its feasibility and optimize its content. participants will have 1 supervised session in the outpatient rehabilitation department. each patient will then perform the home personalized exercises program for 3 months. the feasibility of the program will be assessed at 3 months using patients' adherence to the program (assessed by the number of lost to follow-up, the number of questionnaires not completed, the amount of aerobic activity and the amount of home personalized exercises, treatment burden, adverse effects and quality of life.

ssc is responsible for a reduced life expectancy. the prognosis depends on the presence of severe visceral damage and more particularly on the presence of interstitial lung damage, pulmonary arterial hypertension or specific cardiac damage which represent the 3 main causes of mortality in ssc. the importance of rehabilitation in ssc has been confirmed by the latest inserm collective expertise 2019). the objectives of functional rehabilitation in ssc are to prevent and/or reduce the specific (cutaneous, oral, cardiorespiratory, musculoskeletal) and non-specific (exercise deconditioning, fatigue, anxiety and depression) impairments frequently characterizing the evolution of the disease. based on the latest practice recommendations for the diagnosis and treatment of idiopathic pulmonary fibrosis, people with a confirmed diagnosis of idiopathic pulmonary fibrosis and significant exercise and activity limitations should follow a respiratory rehabilitation program. the value of a specific respiratory rehabilitation program for people with ssc is then a matter of interest. a pilot study is needed to assess the feasibility and optimize the content of a rehabilitation program. the investigators aimed to study the feasibility of a personalized home-based respiratory rehabilitation program in people with ssc with early lung disease.

Eligibility criteria:
inclusion criteria: * systemic sclerosis according to acr/eular 2013 criteria * lung involvement, with fcv \> 70% on pft exclusion criteria: * inability to understand french * pregnancy or breastfeeding * arterial pulmonary hypertension \> 35 mmhg and unexplained dyspnoea or arterial pulmonary hypertension \> 40 mmhg * major musculoskeletal impairment incompatible with physical activity * other pulmonary disease decreasing fcv * pathological ekg * oxygen saturation at rest or during physical activity \< 90% * fcv \< 70%

Keywords: systemic sclerosis lung disease rehabilitation respiratory deficiencies feasibility study
efficacy of the dabir surfaces micropressure overlay for decubitus ulcer prevention during cardiac surgery

Conditions: Pressure Ulcer; Pressure Injury

Summary: this is a systematic random sampling study of the effects of the dabir micropressure overlay on perioperative pressure injuries during cardiac surgery.

this is a simple pragmatic systematic quality improvement study aimed at real-world evaluation of a device claimed to reduce pressure ulcers in patients undergoing cardiac surgery. data acquisition will be based on systematic sampling of cardiac surgery operations based on odd and even calendar dates. on odd dates the dabir micropressure overlay will be functional on the operating room tables. on even dates the dabir micropressure overlay will not be functional on the operating room tables. data on baseline characteristics, operative parameters, and primary and secondary endpoints will be gathered from sts and wound care sources, which are routinely collected for all patients. there will be no additional patient information and data collected specifically for this study.

Eligibility criteria:
inclusion criteria: * all cases scheduled in the cardiac surgery or suites at the ccf main campus. exclusion criteria: * patients who have had previous surgery within 5 days of enrollment in the study will excluded from analysis.
effect of wearing personal protective equipment (ppe) on cpr quality in times of the covid-19-pandemic

Conditions: Cardiopulmonary Resuscitation; Personal Protective Equipment

Summary: background the significant risk of transmission of sars-cov-2 to healthcare staff mandated changes to basic and advanced life support (bls and als) guidelines. as advised by the european resuscitation council (erc), healthcare staff should put on airborne-precaution personal protective equipment (ppe) before starting chest compressions and/or airway interventions, as a minimum an ffp3 mask (ffp2 or n95 if ffp3 not available), eye and face protection and long-sleeved gown. however, wearing ffp3 masks has been shown to highly impair cardiopulmonary exercise capacity and the effect of wearing ppe on the quality of cardiopulmonary resuscitation is not known. the aim of this project is therefore to to investigate whether wearing ppe has an effect on the quality of chest compressions. methods the study forsees a simulated cpr scenario on manikins. study participants are lay rescuers and members of the rescue organization croce bianca. each participant will perform 5 sequences consisting of 2 min of chest compressions altered by 2 min of no chest compressions (break), as recommended by the current erc guidelines. the participants will perform the described cpr sequence two times in a cross-over design with randomized order, once while wearing ppe and once without wearing ppe. between the two cpr sequences (i.e. with and without ppe) a break of 60 min for recovery will be given. during both cpr sequences, the quality of chest compressions will be measured.


Eligibility criteria:
inclusion criteria: * member of the rescue organization "croce bianca" * aged 18-60 * certified in basic life support (bls) * no current covid-19 symptoms, not being tested positive for covid-19, no covid-19 symptoms in the 4 weeks before the tests, no quarantine or unprotected contacts with covid positive patients in the last 4 weeks, body temperature ≤ 37.5°on test days. * obtained informed consent. exclusion criteria: * age \ 60 years, * no informed consent * current covid-19 symptoms, being tested positive for covid 19 or symptoms in the 4 weeks before the tests, quarantine or unprotected contacts with covid-19 positive patients in the last 4 weeks, body temperature ≥ 37.5°on test days.