Kornimate/medical-research-clean huggingface dataset:
the efficacy of minayo iron-rich yeast drink with sod on female nutritional anemia, skin condition and qi-blood deficiency syndrome

Conditions: Anemia; Skin Condition

Summary: the goal of this single arm, open-label study is to learn about the efficacy of minayo iron-rich yeast drink with sod on females who are aged 18-35 and suffer nutritional anemia, skin condition and qi-blood deficiency syndrome. the main question it aims to answer is: - whether the serum ferritin level in blood is improved after the intervention 14 qualified participants will be enrolled to drink the product "minayo iron-rich yeast drink with sod" for four weeks, once a day. four site visits will be made for each participant so that all relevant clinical data will be captured and recorded for data analysis and reporting. researchers will compare the final blood test result (hemoglobin concentration level, glutathione (gsh), superoxide dismutase (sod)) against the baseline to conclude whether the product will be effective in improving anemia and skin conditions.


Eligibility criteria:
inclusion criteria: * female, aged 18 to 35; * hemoglobin concentration level below 110g/l based on who diagnostic criteria for anemia; * agree not to take any drugs, supplements, or other dairy products during the trial; * agree not to take any other medications or supplements containing iron during the trial; * willing to refrain from participating in other interventional clinical studies during the trial period; * be able to fully understand the purpose, benefits and potential risks including side effects of the research; * willing to obey all test requirements and procedures; * informed consent signed. exclusion criteria: * anemia caused by organic diseases; * subject who is in the treatment of gastrointestinal symptoms; * lactose intolerance; * subject who is currently presence of other organic diseases affecting intestinal function, such as history of gastrointestinal resection, colon or rectal cancer, inflammatory bowel disease, diabetes, hyperthyroidism or hypothyroidism, congenital megacolon, scleroderma, anorexia nervosa, etc.; * controlling diet, exercising, or taking medications to control weight or affect appetite in the last 3 months; * subject who has any of the following medical history or clinical findings that may affect the evaluation of the trial effect: significant gastrointestinal disorders, liver, kidney, endocrine, hematological, respiratory and cardiovascular diseases; * abuse alcohol or other drugs, supplement or otc drugs currently or n the past may cause bowel dysfunction or can affect test result evaluation; * frequently use of medications that may affect gastrointestinal function or the immune system according to investigator's judgment; * take laxatives or other substances that promote digestion 2 weeks before the trail start; * subject who used drugs or supplements of iron agent 10 days before the beginning of the trial; * pregnant or lactating women or those planning to become pregnant during the trial; * pi deems that subjects could not fully cooperate with trial arrangements.

Keywords: minayo iron-rich yeast drink sod gsh
vascular effects of sitagliptin in diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: glucagon-like peptide 1 (glp-1) is a 30-amino acid gut hormone secreted in a nutrient-dependent manner that stimulates insulin secretion and inhibits glucagon secretion and gastric emptying, thereby reducing postprandial glycemia.1,2 glp-1 is derived from posttranslational proteolysis of preproglucagon, and its peptide sequence is identical in mouse, rat, and human.2,3 after secretion from enteroendocrine l cells, glp-1(7-36) amide is rapidly degraded by dipeptidyl peptidase-4 (dpp-4) to its n-terminally truncated metabolite glp-1(9-36), which does not interact with the known glp-1 receptor.4,5 the diverse actions of glp-1 include the proliferation, differentiation, and protection from apoptosis of pancreatic β cells and the induction of satiety. glp-1 also improves memory and learning, stimulates afferent sensory nerves, and has neuroprotective functions.1,6 furthermore, glp-1 receptor agonists have been reported to have cardiac and vascular actions in rodents and humans that include effects on contractility, blood pressure, cardiac output,7-10 and cardioprotection.11-14

the aim of this study is to evaluate the effect of a therapy with the dpp-4-inhibitor sitagliptin on the prognostic relevant endothelial function and endothelial progenitor cells in patients with type 2 diabetes mellitus. primary endpoint: endothelium-dependent vasodilation before and after treatment of patients with type 2 diabetes mellitus with the dpp-4-inhibitor sitagliptin and placebo treatment respectively. secondary endpoint: effect of sitagliptin on mobilization, no-production and in vivo regenerative capacity of human endothelial progenitor cells before and after treatment of patients with type 2 diabetes mellitus with the dpp-4-inhibitor sitagliptin and placebo treatment respectively

Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus exclusion criteria: * allergy to sitagliptin * treatment with ppar-gamma agonist
a study to assess the long-term safety and efficacy of atb200/at2221 in adult subjects with lopd

Conditions: Pompe Disease (Late-onset)

Summary: this is a multicenter, international open-label extension study of atb200/at2221 in adult subjects with late-onset pompe disease (lopd) who completed study atb200-03.

this is an open label extension study for subjects who completed the atb200-03 study. the subjects will stay in this study until regulatory approval or marketing authorization and/or commercialization in the participating subject's country.

Eligibility criteria:
inclusion criteria: 1. subject must have completed study atb200-03. exclusion criteria 1. subject plans to receive gene therapy or participate in another interventional study for pompe disease. 2. subject, if female, is pregnant or breastfeeding. 3. subject, whether male or female, is planning to conceive a child during the study.

Keywords: pompe rhgaa
muscle strength assessment in patients with chronic ankle instability

Conditions: Chronic Ankle Instability

Summary: patients with chronic ankle instability (cai) show biomechanical and neuromuscular alterations during the performance of functional movements not only at the ankle joint level, but also in more proximal joints and segments. few studies have been conducted to investigate the effects of chronic ankle instability on neuromuscular control at the knee joint level. the aim of this study is to investigate whenther abnormalities exists in maximal and sub-maximal isometric muscle strength expression in patients with cai.


Eligibility criteria:
inclusion criteria: * age between 18 and 40 years * chronic ankle instability * physically active individuals exclusion criteria: * sedentary behaviour * previous injuries or surgeries to the lower limbs * neurological disorders

Keywords: ankle instability muscle strength quadriceps hamstrings maximal voluntary isometric contraction
losartan for patients with covid-19 not requiring hospitalization

Conditions: Corona Virus Infection; Acute Respiratory Distress Syndrome; SARS-CoV Infection

Summary: this is a multi-center, double-blinded study of covid-19 infected patients randomized 1:1 to daily losartan or placebo for 10 days or treatment failure (hospital admission).


Eligibility criteria:
inclusion criteria: * positive laboratory test for covid-19 based on local laboratory standard * age greater than or equal to 18 years of age * one of the following: upper respiratory symptoms (cough, rhinorrhea) or fever (\>101.5) or loss of taste / smell exclusion criteria: * randomization \> 72 hours of meeting inclusion criteria * randomization \> 7 days of symptom onset * currently taking an angiotensin converting enzyme inhibitor (acei) or angiotensin receptor blocker (arb) * prior reaction or intolerance to an arb or ace inhibitor, including but not limited to angioedema * pregnant or breastfeeding women * females able to have children not currently taking a protocol allowed version of contraception: intrauterine device, depo-formulation of hormonal contraception (e.g. medroxyprogesterone acetate/depo-provera), subcutaneous contraceptive (e.g. nexplanon), daily oral contraceptives with verbalized commitment to taking daily throughout the study, condom use or abstinence during the study. all participants of child bearing potential enrolled in this fashion will be informed of the teratogenic risks. * patient reported history or electronic medical record history of kidney disease, defined as: 1. any history of dialysis 2. history of chronic kidney disease stage iv 3. estimated glomerular filtration rate (egfr) of \< 30ml/min/1.73 m2 (must be have been measured within 1 month of enrollment) 4. other kidney disease that in the opinion of the investigator, would affect losartan clearance * patient reported dehydration and significantly decreased urine output in the past 72 hours * most recent systolic blood pressure prior to enrollment \<110 mmhg * patient reported history or electronic medical record history of severe liver disease, defined as: 1. cirrhosis 2. history of hepatitis b or c 3. other liver disease that in the opinion of the investigator, would affect losartan clearance 4. documented ast or alt \> 3 times the upper limit of normal within 3 months of randomization (if available in electronic medical record) * potassium \>5.0 mmol/l (must have been measured within 1 month) of enrollment * concurrent treatment with aliskiren * inability to obtain informed consent * enrollment in another blinded randomized clinical trial for covid

Keywords: covid-19 corona virus sars-cov-2
chemopreventive action of mesalazine on colorectal cancer: a pilot study for an "in vivo" evaluation of the molecular effects on β-catenin signaling pathway.

Conditions: Colorectal Cancer

Summary: the purpose of this study is to obtain an "in vivo" confirmation that mesalazine induces the gene expression of μ-protocadherin and other related genes in the colon mucosa, as demonstrated in some "in vitro" experiments. .

pilot trial, single-blind, parallel group on biopsy specimens of healthy colon mucosa in patients with precancerous lesions of the colon and rectum (adenomas) treated with mesalazine.

Eligibility criteria:
inclusion criteria: * patients with precancerous colorectal lesions (polypoid or nonpolypoid adenomas) that needs of an endoscopic exam of control after 3 months from the removal of the lesions (determined on the basis of the morphological and histological characteristics of the lesions and of the removal technique) * ability and willingness to adhere to study regimen * written informed consent the following inclusion criteria was deleted according to amendment n. 01 approved by the ethical committee on 19/dec/2014: - diverticular disease/diverticular colitis; the rationale of this change is that the presence of diverticular disease/diverticular colitis does not contribute to the definition of the trial primary end-points and represents a critical point during the patient selection with an impact on duration and conduction of the study. exclusion criteria: * patients under therapy with aspirin (\>100 mg/die) or other fans * inflammatory bowel disease (ibd) * hypersensitivity to mesalazine. * pregnant or nursing (lactating) women * patients who belonging to the category n. 4 of the asa physical status classification system * contraindications to mesalazine therapy

Keywords: mesalazine colon cancer
cystic fibrosis (cf) flow rates study

Conditions: Cystic Fibrosis

Summary: we wish to measure the inspiratory flow and volumes generated by the subjects inhaling from a spirometer with a high resistance dry powder inhaler in series in subjects with cystic fibrosis.


Eligibility criteria:
inclusion criteria: * cf * fev1 ≥ 30% and \< 90% predicted exclusion criteria: * be considered "terminally ill" or listed for lung transplantation * have had a lung transplant * have had a significant episode of haemoptysis (\>60 ml) in the three months prior to enrolment * have had a myocardial infarction in the three months prior to enrolment * have had a cerebral vascular accident in the three months prior to enrolment * have had major ocular surgery in the three months prior to enrolment * have had major abdominal, chest or brain surgery in the three months prior to enrolment * have a known cerebral, aortic or abdominal aneurysm * be breast feeding or pregnant * be using beta blockers * have unstable asthma

Keywords: device characteristics
brief app-based mood monitoring and mindfulness intervention for first-year college students

Conditions: Depression, Anxiety; Self-Injurious Behavior

Summary: the investigators examined whether brief, app-based interventions were helpful in alleviating mental health symptoms during the transition to college. in particular, the investigators were interested in whether a brief mobile-app mindfulness intervention combined with mood monitoring was more effective in alleviating first-year students' psychological distress than mood monitoring alone.

the transition to college is associated with worsening mental health symptoms. this study tested whether a brief mobile-app mindfulness intervention combined with mood monitoring was more effective in alleviating first-year students' psychological distress than mood monitoring alone. participants were 130 first-year students. the investigators randomly assigned 88 students to a mindfulness-plus-mood-monitoring or a mood-monitoring-only group and asked them to use an app 3 times a day for 3 weeks. they, along with an assessment-only control group (n=42), completed self-report questionnaires at baseline, post-intervention, and 6 and 12 weeks later.

Eligibility criteria:
inclusion criteria: * enrolled first-year student at university exclusion criteria: * serious suicidal concerns

Keywords: mindfulness rumination worry
syndesmotic screw in neutral position versus maximum ankle dorsiflexion in ankle fractures; comparative study.

Conditions: Syndesmotic Injuries

Summary: ankle fracture is one of the most common orthopedic injuries. approximately, 20% of surgically treated ankle fractures are associated with syndesmotic instability.according to the mechanism of the injury the syndesmotic disruption should be considered in danis-weber c-type fractures. however, such injuries were also frequently seen in danis-weber b-type fractures. failure to detect and repair syndesmotic injuries early may result in poor clinical outcomes and complications affecting ankle function, such as long-term residual pain, post traumatic arthritis, and ankle impingement syndromes. therefore, aggressive treatment is important when facing syndesmotic instability . the distal tibiofibular syndesmosis is important for stability of the ankle mortise and thus for weight transmission and walking. syndesmotic injuries are most commonly associated with fibular fractures, but they can also occur in isolation or with damage to the lateral ankle ligament after traumatic supination. the need for syndesmotic fixation of the distal tibiofibular joint has been controversia. fracture does not correlate reliably with the extent of the interosseous membrane tears identified on mri of ankle fractures, and thus estimation of the integrity of the interosseous membrane and subsequent need for trans-syndesmotic fixation cannot be based solely on the level of the fibular fracture. an intraoperative syndesmotic stress test can establish the presence or absence of syndesmotic instability, evaluating the integrity of the syndesmosis by grasping the stabilised fibula with a hook or clamp and pulling it laterally. if more than 3 or 4 mm of lateral displacement occurs, syndesmotic fixation is necessary. most authors recommend surgical placement of a trans-fixation screw after anatomical reduction of the syndesmosis if a disruption is diagnosed to avoid complications.the main aims of treatment for dislocation of the distal tibiofibular syndesmosis are to restore the original anatomy and normal function and to recreate the stability of the ankle joint. the syndesmosis is traditionally fixed with a metallic screw, which is a method that has been used for decades and demonstrates good to excellent outcomes. some surgeons prefer fixation of syndesmosis with screw in maximum ankle dorsiflexion and others prefer fixation in neutral position of ankle.in this study we are going to compare between these two


Eligibility criteria:
inclusion criteria: * patients with fracture ankle type c and type b associated with syndesmotic injury exclusion criteria: * pathologic fractures * maisonneuve fractures * medical illness or mental disorders affecting the follow-up examination * loss to follow-up
development and evaluation of an adaptive web-based intervention for copd

Conditions: COPD (Chronic Obstructive Pulmonary Disease)

Summary: narrative-based tiered asynchronous psychosocial and behavioral whole health support for people adjusting to living with copd. the intervention is administered by experienced lcsws under the pi's supervision.

this study will advance health access equity for people with chronic obstructive pulmonary disease (copd) by providing an asynchronous, patient-led, web-based, adaptive, flexible, and tiered intervention that easily integrates into the daily lives of both providers and patients living with copd. this intervention includes health navigation education, health and behavior coaching, and narrative, strengths-based mental and behavioral health support. copd is a complex chronic illness with multiple domains to study whole person support. not only because of the significant impact of a lack of whole person support for people living with copd but also because copd shares many of the same symptomology and impact on daily living as other significant chronic illnesses such as heart failure, some neurological disorders, and some types of cancer (5-7). the lessons learned from studying copd whole person support can be applied to other similar symptomatic burdensome chronic illnesses that also suffer from fragmented care.

Eligibility criteria:
inclusion criteria: * has access to the internet once per week * has been diagnosed with copd and is being seen at the echcs va medical center or the university of colorado pulmonology clinics exclusion criteria: * not in a conflicting research study

Keywords: asynchronous whole health support website based intervention implementation access to whole health care
induction in the dark

Conditions: Anesthesia Induction

Summary: this study will enroll children ages 2-6 who are undergoing an elective outpatient surgical procedure under general anesthesia. they will be randomized to one of the following groups and assessed for preoperative anxiety, mask acceptance, and behavioral changes in the following week. 1. darkened room and star projector with parental presence; 2. preoperative midazolam 0.5 mg/kg by mouth and parental presence; or 3. parental presence alone.


Eligibility criteria:
inclusion criteria * age 2 to 6 years old * american society of anesthesiologists physical status i-ii * outpatient elective surgical procedures * undergoing general anesthesia * parent or guardian willing to be present during induction exclusion criteria * history of previous surgery * fear of the dark * contraindication to inhalational mask induction of general anesthesia such as allergy to inhalation medication, npo violation, active nausea or vomiting, severe gerd, etc. * severe developmental delay * severe obvious, preoperative anxiety * patients currently using psychiatric medications * non-english speaking
clozapine use pattern in the province of seville

Conditions: Schizophrenia and Related Disorders

Summary: clozapine use pattern in the province of seville

subjects with a diagnosis of schizophrenia (f20 of icd-10) under treatment with clozapine in the province of seville. the use of clozapine, variability between centers and treatment modification will be identified.

Eligibility criteria:
inclusion criteria: patients who have been prescribed (initially or regularly) clozapine during 2018, based on the casuistry provided by the pharmacy service of the different hospitals. exclusion criteria: * parkinson's disease * dementia

Keywords: clozapine
primary stability of implant in closed sinus lifting cases using densah bur versus osteotome

Conditions: Sinus Pneumatization

Summary: this study is aiming to evaluate primary stability of implant in closed sinus lifting cases by densah bur in compared to osteotome in partially edentulous patients hoping that densah bur can lift the sinus membrane and improve primary stability of implant.

the osteotome technique is effective in certain cases, but the most sensitive aspect is the tapping force, which should be sufficient enough to infracture the sinus floor cortical bone but restrained enough to prevent the osteotome tip from traumatizing the schneiderian membrane. several surgical techniques have been proposed to minimize the sinus membrane perforation rate by using a piezosurgical device, balloon, hydrostatic pressure. the success of therapy in posterior maxilla is not only dependent on the success of the sinus elevation but also the primary stability of the implant that allow bone apposition on the implant surface without any micromovement for osseeointegration. later, densah burs are introduced as another treatment option for internal transalveolar approach of sinus floor elevation with improving primary stability of implant by osseodensification. as treatment options of edentulous maxillary today may include dental implants, the practitioner must be familiar with various sinus lift surgical techniques in order to choose an ideal treatment option for the patient.

Eligibility criteria:
inclusion criteria: * both males as well as females without any active periodontal disease. * all patients were in a good health with no systemic diseases. * all selected patients were non-smokers and non-alcoholics. * patient were free from t.m.j troubles, abnormal oral habits such as bruxism. * the edentulous ridges were covered with optimal thickness of soft tissue. * remaining natural teeth had good. * periodontal tissue support and occlusion showed sufficient inter arch space. * on the local level, patients with maxillary sinus diseases and unfavorable inter maxillary relationship were excluded. exclusion criteria: * patients with residual bone height less than 6mm. * patients with systemic disease that may affect bone quality. * patients with poor oral hygiene and active periodontal diseases. * patient with limited mouth opening.

Keywords: closed sinus lifiting implant stability osteotome densah bur