Kornimate/medical-research-clean huggingface dataset:
muscle function and pelvic stability while walking in patients with symptomatic lumbar spinal stenosis

Conditions: Symptomatic Lumbar Spinal Stenosis; Lumbar Spinal Stenosis

Summary: this study is to quantify changes in muscle activity and pelvic stability during prolonged walking in patients with symptomatic lumbar spinal stenosis (slss) and healthy control subjects and to determine their association with the severity of the stenosis and the crosssectional area and fatty atrophy of lumbo-pelvic-hip muscles.


Eligibility criteria:
inclusion criteria patients: * diagnosed symptomatic lumbar spinal stenosis * availability of lumbar mr images * scheduled for decompressive surgery at the university hospital basel exclusion criteria patients: * prior decompressive surgery * body mass index (bmi) ≥ 35 kg/m2 * additional pathologies that influence the mobility of the pelvis * use of walking aids * inability to provide informed consent exclusion criteria healthy control subjects: * bmi ≥ 35 kg/m2 * pain in the lower extremity or lower back in the previous 6 months * prior surgery of the lumbo-pelvic-hip complex * history of claudications * neurological or orthopaedic conditions that may influence gait * inability to provide informed consent

Keywords: pelvic stability lumbo- pelvic- hip complex lumbo-pelvic-hip muscles
controlling asthma at school

Conditions: Asthma; Lung Diseases

Summary: to implement and evaluate a coordinated set of activities for asthma identification, education, management, and prevention in the predominantly minority inner city schools in the detroit metropolitan area.

background: the study was part of an initiative "interventions to improve asthma management and prevention at school". the broad agency announcement was released in june, 1994. design narrative: the intervention was a combination of: targeted education for children with asthma, other children in the school, families, physicians and school personnel; concerted effort to change school policies working against effective self-management of asthma; community action/education to create awareness and support for the schools' efforts to control the disease. open airways for school, a proven educational program, was adapted for students in the detroit metropolitan area as part of the intervention. this program was based on social cognitive theory while modeling effective asthma management behavior, involving students in activities where they mastered skills relevant to asthma management, and developing the students' sense of confidence to carry out asthma management tasks. for education of all students, a learning module called "environmental detective" was developed to complement the michigan model of comprehensive health education offered in classrooms in michigan. the environmental detective game sensitized children without asthma to the problems of children with asthma. the intervention was evaluated through a controlled research design to determine if it had an impact on asthma morbidity, the number of days of limited activity of the child with asthma, and his or her academic performance. the project was a collaboration of the university of michigan school of public health and school of medicine, the henry ford hospital center of detroit, the washtenaw county health and human services department, the american lung association of michigan, and the state of michigan department of education. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
tele-spirometry in primary care-randomized clinical trial cluster:telemedicine in chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of this study is to determine the effectiveness of telemedicine multifaceted intervention in symptoms patients with chronic obstructive pulmonary disease.

this study is a randomized clinical trial for patients with chronic obstructive pulmonary disease from a primary care. the purpose is to determine the effectiveness of telemedicine (teleconsultation and telemonitoring) in control of chronic obstructive pulmonary disease symptoms.

Eligibility criteria:
inclusion criteria: * spirometry from telessauders-universidade federal do rio grande do sul (from randomization cluster), modified medical research council dyspnea \> 0 exclusion criteria: * normal or restrictive spirometry, low quality spirometries (inadequate)

Keywords: telemedicine chronic obstructive pulmonary disease primary health care spirometry
efficacy of aprepitant (emend®) in children

Conditions: Nausea; Vomiting; Childhood Cancer

Summary: the purpose of this study is to find out whether or not adding aprepitant(emend®) to the standard therapy will help children who receive chemotherapy to have less nausea and vomiting.

1.1 primary aim to determine the efficacy of aprepitant (emend®) in preventing and reducing chemotherapy-induced nausea and vomiting (cinv) when added to standard antiemetic drug regimens for children receiving highly emetogenic chemotherapy. the working hypothesis will be that standard therapy + aprepitant is superior at preventing cinv than standard therapy + placebo. 1.2 secondary aim to evaluate the safety and toxicity of aprepitant (emend®) in children receiving highly emetogenic chemotherapy when compared to standard antiemetic therapy + placebo.

Eligibility criteria:
inclusion criteria: under 20.99 years of age at enrollment scheduled to receive two identical cycles of highly emetogenic\[1\] chemotherapy for treatment of a primary malignancy, including: chemotherapy with any one or more of the following single agents in any combination: * carboplatin * carmustine \>250 mg/m2 * cisplatin * cyclophosphamide ≥1 g/m2 * dactinomycin * high dose methotrexate ≥ 5 g/m2 or any of the following defined combinations: * cyclophosphamide + anthracycline * cyclophosphamide + etoposide * cytarabine 150-200 mg/m2 + daunorubicin * cytarabine 300 mg/m2 + etoposide * cytarabine 300 mg/m2 + teniposide * doxorubicin + ifosfamide * doxorubicin + methotrexate 5 g/m2 * etoposide + ifosfamide exclusion criteria: * patients who have received aprepitant in the past. * patients who demonstrate evidence of increased intracranial pressure.

Keywords: nausea vomiting children aprepitant emend®
tobramycin tear concentrations

Conditions: Dry Eye

Summary: to evaluate the tobramycin tear concentration values of tobradex® ophthalmic suspension, tobramycin 0.3% / dexamethasone 0.05% ophthalmic suspension versus tobrex® ophthalmic solution in normal volunteers.


Eligibility criteria:
inclusion: * visual acuity (va) of 0.6 logmar or better * tear meniscus height of ≥ 0.3mm at visit 1. * no concomitant topical ocular medications, including artificial tears, during the study period exclusion * ocular hypertension, iritis or uveitis, glaucoma * ocular surgery, intraocular surgery or ocular laser procedures in either eye within the past six months * epithelial herpes simplex (dendritic keratitis); vaccinia, active or recent varicella viral disease of the cornea and/or conjunctiva; ocular rosacea; mycobacterial infection of the eye; and / or fungal disease of the eye * lacrimal duct obstruction, dry eye, ocular allergies. * contact lens within 7 days of visit 1. * ocular medications within 14 days of visit 1.

Keywords: normal volunteers anti-infective tobramycin
cross-disciplinary workplace intervention strategy for chronic musculoskeletal disorders

Conditions: Back Pain; Neck Pain; Musculoskeletal Abnormalities

Summary: sickness absenteeism caused by msds is a persistent and expensive health challenge in all industrial countries including switzerland. despite much progress as to the cause and prevention of msds, they continue to be some of the most prevalent and challenging health problems with respect to the work-place and to socio-economic burden. to improve the situation, several recent reviews recommended interventions based on the bio-psycho-social model. work-hardening and industrial rehabilitation programs focused more on the in balance between physical and mental demands of work on one side and capacities of the individual on the other side. therefore we propose to merge the two models into one. the result is an interdisciplinary intervention strategy witch includes work hardening, medical trainings, a cognitive behavioural approach and work place intervention.


Eligibility criteria:
inclusion criteria: * employees on sick leave because of non-specific back and/or neck/shoulder pain * actual unable to work and continuous or cumulative (totalized) work incapa- city in the past 6 monts * ≥ 20 working days 100% absence from work or * ≥ 40 working days 80 to 99% absence from work or * ≥ 60 working days 50 to 79% absence from work and * not older than 58 level of employment ≥ 50% * no longer than 6 monts absencer from work (100% unable to work) exclusion criteria: * specific diagnosis such as infection, neoplasm, metastasis osteoporosis, rheumatoid arthritis, fracture and inflammatory process or other conditions for which valid diagnoses had been demonstrated either in the anamnesis, records or the clinical examination * postoperative health condition with prohibited physical load * major co-morbidity which may determine return to work in a clearly stronger way then the msd itself such as a major depression, psychosis, heavy drug or alcohol disease or instable cardiac or pulmonary disease * predominant specific shoulder pathology in "neck-shoulder pain"

Keywords: work musculoskeletal disorders
comparing the efficacy of several popular online interventions to reduce hazardous alcohol consumption

Conditions: Alcohol Consumption

Summary: there are a number of popular, freely available online interventions targeting hazardous alcohol consumption. unfortunately, most have limited or no published evidence regarding their efficacy. of particular interest is the intervention, 'hello sunday morning.' the current project proposes to evaluate its' efficacy employing a rct, using the check your drinking intervention as an active comparator in the trial. participants will be recruited through amazon's mturk crowdsourcing platform. potential participants identified as problem drinkers based on an initial survey will be invited to complete another survey in 6 months time. those who agree to be followed-up will be assigned by chance to be asked versus not asked to access one of the interventions and then recontacted 6 months later to ask about their drinking and their impressions of the online intervention. the primary hypothesis to be tested is that participants receiving access to any of the online interventions will report a greater level of reduction in number of drinks in a typical week between the baseline survey and six-month follow-up as compared to participants in the control condition.


Eligibility criteria:
inclusion criteria: * 18 years of age or over * a score of 8 or over on the alcohol use disorders identification test (audit) * typically consumes 15 or more drinks per week, * willingness to complete a 6-month follow-up survey exclusion criteria: none
preoperative staging of endometriosis with mri

Conditions: Endometriosis

Summary: the purpose of the study is to evaluate the value of mri in preoperative stratification of endometriosis patients needing surgical approach by gynaecologists only or multidisciplinary approach by gynaecologists, urologists or/and abdominal surgeons.

the purpose of the study is to evaluate the value of mri in preoperative stratification of endometriosis patients needing either a surgical approach by gynaecologists only or multidisciplinary approach by gynaecologists, urologists or/and abdominal surgeons.

Eligibility criteria:
inclusion criteria: * women with strong suspicion of deep infiltrating endometriosis, with already planned surgery exclusion criteria: * contra-indications for mri; claustrophobic patients; patients in bad condition; pregnancy

Keywords: endometriosis magnetic resonance imaging
towards optimal fertility, fathering and fatherhood study

Conditions: Reproductive Issues; Fertility Issues

Summary: this case-control study involving fertile and subfertile couples aims to identify male factors related to pregnancy likelihood, create a fertility index measure combining male and female factors to predict pregnancy likelihood, and examine how male factors relate to the semen physical and biological characteristics.

paternal contributions to fertility and reproductive health outcomes have been understudied, despite promising evidence from animal studies. this study aims to investigate the male contribution to pregnancy likelihood and explore the underlying biological mechanisms. specifically, the investigators aim to (1) identify male factors associated with pregnancy rate; (2) develop a fertility index combining modifiable factors for both males and females to predict pregnancy rate; and (3) explore the relationship of male modifiable factors with semen physical and molecular characteristics. this is a case-control study with 480 fertile and subfertile males (along with their female partners), recruited from kk women's and children's hospital. the investigators will use questionnaires to collect data on socio-demographic characteristics, clinical, lifestyle, and environmental factors; analyze metabolic and stress biomarkers from blood samples; and measure semen parameters including sperm motility, density, morphology, volume, dna fragmentation, dna methylation, gene expression, and seminal plasma oxidative status. findings from this proposed study will pave the way for developing lifestyle-based or medical interventions to enhance male and couple reproductive health, and potentially benefiting future offspring health.

Eligibility criteria:
inclusion criteria: subfertile couples: * men aged ≥21-49 years * men with a female partner aged 21-39 years * couples who are not able to conceive for at least 12 months * couples who are singapore citizen or permanent resident fertile couples: * men aged 21-49 years * men with a female partner aged 21-39 years * men with proven fertility defined as those female partners who are currently pregnant and with viable intrauterine pregnancy at gestational weeks of less or equal to 16 at the time of the study * couples with attempted time to conceive within 12 months to achieve this pregnancy or with unplanned pregnancy * couples who are singapore citizen or permanent resident exclusion criteria: subfertile couples: * male infertility of a known aetiology including azoospermia, retrograde ejaculation, genetic disorders, cancer treatment, or testes trauma * female infertility diagnosis as confirmed by diagnostic imaging or having severe endometriosis * female partners with irregular menstrual cycle \>35 days * couples with known chromosomal abnormalities fertile couples: * couples who achieve pregnancy after oocyte or spermatozoa donation * couples with known chromosomal abnormalities * female partners with known uterine abnormalities

Keywords: male risk factor lifestyle semen analysis epigenetic oxidative stress dna fragmentation
the ideal local anesthetic for intraperitoneal gallbladder bed infiltration following laparoscopic cholecystectomy

Conditions: Cholecystectomy, Laparoscopic; Pain Management

Summary: to control pain after surgery for removal of gallbladder, local anesthetic agent can be sprayed on the liver bed from where the gallbladder is removed. this study was conducted to identify the ideal local anesthetic agent for this purpose.

laparoscopic cholecystectomy is the gold standard operation for symptomatic cholelithiasis; however, pain remains a major factor increasing morbidity and length of hospital stay. infiltration of gallbladder bed with local anesthetic has been shown to improve post-operative pain after laparoscopic cholecystectomy, although, it is unclear which local anesthetic provides superior pain relief. patients undergoing laparoscopic cholecystectomies were randomized into 3 groups of 30 patients each depending on the local anesthetic instilled in the gallbladder bed; lignocaine (group a), bupivacaine (group b), or a combination of lignocaine and bupivacaine (group c). pain was measured using visual analogue score at 2-, 6-, 12- and 24-hours following surgery

Eligibility criteria:
inclusion criteria: * elective/emergency laparoscopic cholecystectomy * asa grade i/ii * ages 18-75 years exclusion criteria: * patients on chronic analgesics * pts receiving analgesics 24 hours prior to surgery * intraoperative bile spillage or drain placement * cbd exploration or t-tube insertion * bmi \&gt; 40 kg/m2 * pts allergic to, or otherwise not able to receive medications being tested

Keywords: laparoscopic cholecystectomy lignocaine bupivacaine visual analogue scale
anxiety-depressive disorder in primary care and cognitive-behavioral treatment

Conditions: Anxiety-depressive Patients Mild to Moderate

Summary: objective: evaluate the effectiveness of quality of life score, a cognitive-behavioral intervention by psychologists in the field of primary care in anxiety-depressive patients, mild to moderate, compared with usual care. design: clinical trial, multicenter, prospective, and randomized into two parallel groups. scope and subjects: we included a random sample of 246 patients anxious-depressive, mild / moderate, belonging to the target population of 41 doctors from several health centers. intervention: in the 246 patients randomly assigned to the intervention group, with a standardized program of cognitive behavioral therapy applied by psychologists, by the usual treatment or control group, which will be standard care. measurements: the main result will be changes in general health scores of the sf-36. it will also measure the change in frequency and intensity of anxiety-depressive symptoms on the scales hars, hdrs, stai and bdi at baseline and at 2, 6 and 12 months. in addition, also collected for drug use and health services. analysis: analyses were performed by intention to treat, comparing the change obtained in both groups at the end of the 12 month follow up. estimates of the effect attributable to the intervention by the difference in those changes, adjusting in addition to the baseline, the possible confounding covariates or effect modifiers of the intervention, using longitudinal mixed-effects models.


Eligibility criteria:
inclusion criteria: * primary care patients. * adults. * of both sexes. * with disorder mixed anxiety-depressive mild-moderate active diagnosed by their general practitioner and showing more than 4 points in goldberg-anxiety, and more than 3 in goldberg depression. exclusion criteria: * patients under 18 or over 75 years * patients with inability to understand, read or speak spanish * patients with cognitive impairment * patients with severe disease which in the opinion of your doctor have a presumably fatal end during the 12 month follow-up * patients with psychotic disorders or other serious mental disease * patients with attempted suicide or suicidal ideation persistent * patients referred to specialized care * patients who are in private treatment * patients with high probability of loss to follow up.
quality control of esophagogastroduodenoscopy using real-time egd auxiliary system

Conditions: Esophagogastroduodenoscopy

Summary: the aim of our study was to develop an automatic quality-control system and assess the performance of this system in quality control of esophagogastroduodenoscopy.

in this study, the researchers firstly developed an automatic quality-control system, name as eas. next, the researchers applied the system in a endoscopic center and designed a prospective randomised controlled trial to investigate the performance of the system in quality control of esophagogastroduodenoscopy.

Eligibility criteria:
inclusion criteria: * patients undergoing egd examination with anaesthesia; * patients able to give informed consent. exclusion criteria: * patients with the contraindications to egd examination; * patients with a prior egd examination within 1 year before the trial; * patients with frankly upper gastrointestinal malignant lesions that were apparent on endoscopy; * a history of upper gastrointestinal cancers; * allergic to anaesthetic in previous medical history; * patients refused to participate in the trial; * the egd procedure cannot be completed due to stenosis, obstruction, solid food, or complications of anaesthesia.

Keywords: esophagogastroduodenoscopy gastric neoplasm artificial intelligence quality control
acupoint stimulation improves postoperative wound pain

Conditions: Abdominal Surgeries; Pain; Acupuncture Points

Summary: postoperative pain remains one of the most common and distressing symptoms experienced by surgical patients. poorly managed postoperative pain can impede recovery, reduce patient willingness to mobilize, increase the risk of complications, and negatively affect overall quality of life. currently, opioids and nonsteroidal anti-inflammatory drugs (nsaids) are the primary pharmacological strategies for managing postoperative pain. however, these medications often carry the risk of adverse effects and may not adequately address all aspects of patient comfort and recovery. in response to this challenge, this study aims to evaluate the effects of a non-pharmacological, non-invasive intervention-acupoint stimulation-on postoperative wound pain and mobilization in patients undergoing abdominal surgery. ultimately, this study seeks to contribute to the development of more diversified and patient-centered pain management strategies, with the expectation that the integration of chinese and western medicine will lead to improved patient care and enhanced postoperative recovery.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * surgical wound length ≥ 10 cm * american society of anesthesiologists (asa) physical status classification i to iii * receiving intravenous patient-controlled analgesia (iv pca) * clear consciousness and ability to communicate * willingness to participate and provide informed consent exclusion criteria: * presence of arrhythmia * implanted artificial cardiac pacemaker * cutaneous lesions at the acupoint or auricular application sites * history of chronic pain or abdominal surgery within the past 6 months * non-ambulatory status prior to surgery

Keywords: acupoint stimulation postoperative pain