Kornimate/medical-research-clean huggingface dataset:
breast cancer rehabilitation program in improving quality of life in breast cancer survivors

Conditions: Stage I Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer

Summary: rationale: a breast cancer rehabilitation program and exercise therapy may help improve the quality of life of breast cancer survivors. purpose: this clinical trial studies a breast cancer rehabilitation program in improving quality of life in breast cancer survivors.

primary objectives: i. to estimate accrual, retention, adherence, and participation of breast cancer survivors to a breast cancer rehabilitation program. ii. to estimate the variability of weight, six-minute walk, quality of life and other psychosocial and physical measures in women participating in the bcrp. secondary objectives: i. to assess changes in the anthropometric, psychosocial, and physical outcomes over the six-month period of the bcrp. ii. to document the types and the rates of adverse events associated with the bcrp. outline: patients attend exercise therapy sessions over 1 hour 3 times a week for 6 months. exercise therapy sessions are comprised of a 10 minute warm-up of light stretching and aerobic type exercise (walking, cycling), 30 minutes of endurance type exercise (cycle, walking), and 20 minutes of resistance training exercise.

Eligibility criteria:
inclusion * first occurrence of breast cancer * bmi \>= 25 * recently completed treatment(chemotherapy/radiation) for breast cancer (=\< 8 weeks), but can be receiving adjuvant hormonal therapy * willing to comply with study visits, as outlined in the protocol * lives within 30 miles of study site, or willing to travel to study site if outside a 30-mile radius * ability to participate in a moderate exercise program, such as freedom from any orthopedic abnormalities that would prevent participation * ability to understand and the willingness to sign a written informed consent document exclusion * unstable angina * cardiac conduction disturbances * plans to move from the study area * dementia that is medically documented or suspected * advanced arterial disease causing ischemia of any limb * physical immobility * homebound for medical reasons * dependent on wheelchair for mobility * chronic disease which significantly reduces 4-year survival * recurrent breast cancer
examining a training program for for acute lymphoblastic leukemia childhood cancer survivors

Conditions: Childhood Cancer

Summary: acute lymphoblastic leukemia (all) is the most common pediatric malignancy, with the peak incidences occurring in children two to five years of age. children with all received neurotoxic chemotherapy agents for two to three years that causes decreased distal muscle strength and poor timing of muscle activation. after completion of medical treatment, all childhood cancer survivors (all ccs) are more likely to have an inactive lifestyle, resulting in life-long gross motor proficiency differences compared to their peers. all ccs typically do not utilize physical therapists' expertise after medical treatment has been completed. there are limited physical therapy (pt) intervention studies for all ccs.

we are performing a feasibility study to examine a movement based intervention that utilizes fast movements through jumping rope to improve balance, coordination, movement speed, and movement agility. the abilities to generate fast movements are required to perform functional activities and for playing sports. participants will receive five in-person pt sessions and a home program for six weeks. the goal of this research is to determine the feasibility, acceptability, and promise of a pt program that emphasizes fast movements in all ccs.

Eligibility criteria:
inclusion criteria: * children 6-17 years old * completed medical treatment for all within the past five years (1 to 60 months) * speak english. exclusion criteria: * diagnosis of a neurological disorder such as cerebral palsy, down syndrome * currently receiving pt services.

Keywords: physical therapy functional mobility
validity and reliablity of i-tug via encephalog

Conditions: Stroke, Ischemic; Balance Assessment; Smartphones

Summary: this study investigated the test-retest reliability and construct validity of the i-tug, standard tug, and berg balance scale (bbs) using the encephalog smartphone application in individuals with chronic ischemic stroke. a total of 49 participants were assessed in two sessions to evaluate test-retest reliability. construct validity was analyzed using pearson correlation coefficients. standard error of measurement (sem) and minimal detectable change (mdc) values were also calculated.

the study was conducted with 37 individuals diagnosed with chronic ischemic stroke. participants were assessed using the i-tug, tug, bbs, and additional postural sway parameters collected via encephalog. two test sessions were conducted to assess test-retest reliability. pearson correlation coefficients were used to evaluate construct validity, and the standard error of measurement (sem) and minimal detectable change (mdc) were also calculated. inclusion criteria: * voluntary participation, * a diagnosis of stroke, no involvement in any physiotherapy program for at least three months prior to the study, * age between 18 and 75 years, * the ability to walk independently functional ambulation scale (fas) score greater than 3, * the spasticity of the m. gastrocnemius was graded as 2 or less on the modified ashworth scale (mas). exclusion criteria: * severe visual or cognitive impairments, * severe cardiovascular disease, or musculoskeletal conditions or skin disorders that affected the lower extremities.

Eligibility criteria:
inclusion criteria: voluntary participation, a diagnosis of stroke, no involvement in any physiotherapy program for at least three months prior to the study, age between 18 and 75 years, the ability to walk independently functional ambulation scale (fas) score greater than 3, and the spasticity of the m. gastrocnemius was graded as 2 or less on the modified ashworth scale (mas). exclusion criteria: participants were excluded if they had severe visual or cognitive impairments, severe cardiovascular disease, or musculoskeletal conditions or skin disorders that affected the lower extremities.

Keywords: stroke, balance, berg balance scale, rehabilitation, encephalog
effect of topiroxostat on urinary albumin excretion early stage diabetic nephropathy and hyperuricemia with or without gout

Conditions: Diabetic Nephropathy

Summary: the purpose of this study is to investigate the effect of topiroxostat on urinary albumin excretion and the safety in patients with early stage diabetic nephropathy and hyperuricemia with or without gout. participants are randomized to placebo (n=20) or topiroxostat (n=40) for 28 weeks. the investigational drugs for this study are supplied by fuji yakuhin co., ltd.


Eligibility criteria:
inclusion criteria: * diabetes patients * clinically or pathologically diagnosed diabetic nephropathy * hyperuricemic or gout patients * estimated glomerular filtration rate (egfr) \>= 30 ml/min/1.73m\^2 and urine albumin creatinine ratio (uacr) greater than or equal to 45 and less than 300 mg/g exclusion criteria: * patient has known non-diabetic nephropathy (other than nephrosclerosis)
comparison of three vision therapy approaches for convergence insufficiency

Conditions: Comparison of Three Vision Therapy Approaches for Convergence Insufficiency

Summary: we compared the effectiveness of three active vision therapy approaches for convergence insufficiency (ci). patients with eligible criteria and symptomatic ci were included in a prospective study and randomly allocated into three groups. in the home-based vision orthoptic therapy (hbvot) group, patients were trained to do the pencil push-ups procedure 15 minutes per day, five days a week. in the office-based vision orthoptic therapy (obvot) group, 60 minutes of orthoptic therapy using a major amblyoscope twice weekly with additional home orthoptic therapy was prescribed. for the augmented office-based vision orthoptic therapy (aobvot) group, orthoptic exercises using three diopter over-minus lenses and a base out prism, in addition to major amblyoscope and additional home reinforcement was prescribed in the same period of time.


Eligibility criteria:
inclusion criteria: * patients between 15 and 35 years of age who have symptomatic ci using the convergence insufficiency symptom survey (ciss) scoring system. * best-corrected visual acuity ≥ 20/25 * exophoria at near at least 4 prism diopters (△) greater than at distance * near point of convergence more than 6.0 cm break * insufficient positive fusional vergence (pfv) (failing sheard's criterion or pfv ≤ 15 △ base-out) at near distance. exclusion criteria: * amblyopia (va worse than 20/30 in each eye), presence of manifest strabismus, history of ocular surgery, any systemic disorder, anisometropia of more than 1.5 diopter of myopia or hyperopia or significant refractive error, and nystagmus and usage of medications that may impair accommodation or convergence. ,ocular surface abnormalities or history of ocular allergy or those who had previously been treated for ci
the gentle cardiac rehabilitation study

Conditions: Secondary Prevention of Coronary Heart Disease

Summary: the purpose of this study is to develop a tai-chi based exercise program designed for patients who recently had a heart attack and do not wish, or are unable, to attend traditional cardiac rehabilitation.

we will estimate the feasibility, acceptability and safety of two different doses of the tai chi intervention (primary outcome). 60 patients (30 per dose arm) will be randomly assigned to a standard dose of tai chi (the dose used by our group in large studies of heart failure patients) or to a high dose matching the recommended frequency and duration of exercise classes in current crs. acceptability assessments will include surveys and focus groups to formally assess the impact of tai chi on facilitators and barriers to crs in this population. we will also obtain estimates of effect sizes of each dose on accelerometry measured physical activity and on the proportion of patients achieving the current american heart association (aha) recommendation for physical activity (secondary outcome). additional outcomes will be cardiac fitness, quality of life, body weight, and sleep. in addition, we will gather exploratory information on possible mechanisms by which tai chi training may affect physical activity. we will collect information on possible mediators such as exercise self-efficacy, perceived social support, and depression. in addition, since tai chi training is associated with meditative practices aimed at increasing present-moment awareness, we will gather information on mindfulness levels. measurements will be conducted at baseline, 3-, 6-, and 9 months after enrollment.

Eligibility criteria:
inclusion criteria: 1. able to understand and speak english 2. age ≥21 3. physically inactive 4. ability to understand the study procedures and willingness to commit to the demands of the study protocol exclusion criteria: 1. inability or unwillingness to give informed consent 2. planning to move out of the area within the study period 3. unstable angina 4. blood pressure \>200/110 or symptomatic orthostatic blood pressure decrease\>20 mmhg 5. uncontrolled atrial or ventricular arrhythmias; 3rd degree atrio-ventricular block 6. pericarditis or myocarditis 7. recent embolism/thrombophlebitis 8. abnormal stress test without study cardiologist's clearance 9. medical conditions likely to limit lifespan 10. nyha functional class iv 11. signs of cognitive impairment (bomc \>10) 12. orthopedic problems prohibiting tai chi practice 13. ongoing tai chi or other mind-body training 14. current enrollment in a cr program 15. severe depression (hads scores\>14) 16. current drug or alcohol use or dependence that would interfere with adherence to study requirements.

Keywords: physical activity coronary heart disease exercise affect mind/body therapies stress, psychological
the effect of head-neck stretching exercises after thyroidectomy on postoperative pain level and wound healing

Conditions: Postoperative Pain; Postoperative Wound Complication

Summary: background: thyroid diseases are one of the most common health problems all over the world. after thyroidectomy, patients often experience discomfort such as neck pain, shoulder stiffness, shoulder movement difficulty, choking or pressing feeling. head-neck stretching exercises provide neuromuscular coordination and flexibility in patients by reducing pain and muscle weakness. methods: this research was carried out as a pre-test / post-test control group experimental design study in 82 patients in the general surgery clinic of a university hospital in istanbul

thyroid hormones are responsible for many metabolic activities in human physiology. it increases the basal metabolic rate, affects protein synthesis and helps growth of long bones. however, when thyroid functions change in the human body, the individual can be negatively affected and some individuals may require surgical intervention. thyroid surgery is a prominent treatment for goiter, hyperthyroidism, thyroid nodules or thyroid carcinoma. it has been reported that the most important complications after thyroidectomy are laryngeal nerve damage and hypoparathyroidism. therefore, patients generally suffer from uncomfortable symptoms such as neck pain, shoulder stiffness, difficulty moving shoulders, choking or pressing feeling. in addition, it is indicated that in the early postoperative period, patients experience limitation in neck movement and have a robotic walking style in order to prevent possible neck pain and protect the incision area. it is emphasized that these symptoms persist for a while after the operation and negatively affect the daily life of the patient. neck stretching exercises which include basic movements of the neck are simple and effective exercises. stretching exercises provide neuromuscular coordination and flexibility in patients by reducing pain and muscle weakness. for this reason, neck stretching exercises should be performed in early postoperative period and a nurse should teach the patient the head-neck stretching exercises and ensure the patient's comfort after thyroidectomy.

Eligibility criteria:
inclusion criteria: * having agreed to participate in the research verbally and in writing after being informed about the research, * 18 years of age or older, * patients who were able to understand the information given, who could read, write and speak in turkish, who have not any problems preventing verbal communication, and who underwent thyroid surgery were included in the study. exclusion criteria: - patients who suffers from cervical problems before surgery were excluded from the study.
comparison of stellaris standard infusion with stellaris elite

Conditions: Cataract

Summary: clinical performance of phacoemulsification platform stellaris elite with standard irrigation fluid bottles in myopic eyes. anterior chamber depth and patients comfort will be compared between the two groups.

today phacoemulsification is the most important and safest procedure to perform cataract surgery. however, there are factors that can increase the risk of complications, one of them is an intraoperative increase of intraocular pressure (iop) which may cause choroidal haemorrhage, capsular block syndrome, or posterior capsular rupture . also, more regularly, alterations of iop provoke sudden changes of the anterior chamber depth, especially in myopic eyes due to intra-operative inverse irido-capsular block, which may result in pain or discomfort for the patient. the deepening of the chamber also makes the surgical maneuvers more challenging in such eyes. as prevention of such adverse events, it is important to maintain a more or less constant iop intraoperatively. to ensure this, the pressure of the irrigation fluid must be adjusted to the outflow of aqueous humor, usually by adapting the height of the irrigation fluid bottle (passive fluidics system). as a variable vacuum is produced at the phaco tip to enable the suction of lens fragments, there often are fluctuations of iop, therefore the surgeon is required to constantly adjust the height of the irrigation fluid bottle. a novel method to relieve the surgeon of this often-distracting task is to use all-in-one phacoemulsification systems that are able to monitor vacuum flow rates and then adjust the pressure of the irrigation fluid intraoperatively, also resulting in less fluctuations of iop (active fluidics system). this should also result in reduced deepening of the anterior chamber and less risk of the adverse events as explained above.

Eligibility criteria:
inclusion criteria: * age-related cataract in both eyes * scheduled for bilateral cataract surgery * myopic patiens with axial eye length \>25.0mm * age 21 and older * written informed consent prior to recruitment exclusion criteria: * pregnancy (pregnancy test will be taken pre-operatively in women of reproductive age) * preceded ophthalmic surgery * any ophthalmic abnormality that could compromise the measurements * concurrent participation in another drug or device clinical investigation

Keywords: cataract cataract surgery phacoemulsification platform
dietary management of gestational diabetes

Conditions: Diabetes, Gestational; Dietary Modification; Glucose Intolerance During Pregnancy; Body Composition; Birth Weight

Summary: emom is a randomized, controlled trial to compare the effects of two different dietary interventions during pregnancy. the comparison is based on tissue glucose content (using continuous glucose monitoring system) in pregnant women and on neonate body composition. the recruited women (n=60) have been diagnosed with gestational diabetes mellitus, and are of caucasian origin. of the study diets, one is moderately carbohydrate restricted and the other one is high on plant-based protein with an emphasis on healthy nordic foods. the study has two two-week study periods that are carried out on approximately gestational weeks 24-28 (period i) and 34-36 (period ii). continuous glucose monitoring and other measurements (accelerometer, 3-day food record, gut microbiota, serum lipids, metabolomics, epigenetics etc.) are done during these study periods. at the beginning of the study, before study period i, the participants are randomized to either one of the intervention diets. the first study period consists of a crossover phase in which the participants receive three days' worth of food according to one of the intervention diets (according to the randomization) after which there is a three-day wash-out period. after the wash-out period, the participants receive three days' worth of food according to the other diet. after the first study period, a nutritionist advises the lastly followed intervention diet to the participant and the diet is followed until delivery. to ensure the diet is followed, the participants gets at least three personal face-to-face counseling sessions, phone calls, mobile reminders, recipes and food items. after delivery, the infant's body composition, epigenetic markers of cord blood and placenta, gut microbiome and urine metabolomics are measured.


Eligibility criteria:
inclusion criteria: - gestational diabetes at enrollment exclusion criteria: * gestational weeks exceed 28+6 * multiple pregnancy * food allergies or restrictions (other than lactose intolerance) * mother's or father's ethnic background other than caucasian * type 1 or type 2 diabetes * medication which affects glucose metabolism * cholesterol medication * drug or alcohol abuse * psychiatric illness which affects participation in the study * factors hampering communication (e.g. lack of finnish skills)

Keywords: nutrition dietary counseling diet pregnancy
identification of prognostic parameters in patients with " senile " amyloid cardiomyopathy

Conditions: Cardiac Amyloidosis

Summary: the aging of the population is a reality in our society, with a strong increase in the number of elderly patients hospitalized for heart failure in our institutions. heart failure in these patients is more present than to younger patients, with preserved ejection fraction form (hfpef). aging is responsible for the onset of senile amyloid cardiomyopathy. this pathology is still imperfectly understood and its link with the increase in the frequency of hfpef is important. in addition, specific treatments have just shown their effectiveness. it is therefore urgent to better identify the prognostic predictive parameters of this cardiomyopathy. the pathophysiological involvement of the coronary microcirculation responsible for a true microvascular coronary disease (cmvd) has been described as predictive factor in all cardiomyopathies. however the implementation of preventive strategies and / or therapeutic of the coronary microcirculation dysfunction are limited because we lack of diagnostic tests available and applicable to large cohorts of patients. our team inserm u1039 radiopharmaceutiques biocliniques in collaboration with the laboratory gipsa-lab (grenoble images speech signal automatique), laboratory specialized in the signal analysis, has developed a new method of analysis allowing to measure the coronary microcirculation dysfunction usable in spect thanks to the measurement of a myocardial perfusion heterogeneity index (ihpm) (patented technique). the 3c registry (nct03479580) is a registry studying the prevalence and cardiovascular prognosis of macro and microcirculatory coronary artery disease using the latest coronary evaluation techniques in patient with cardiomyopathy. this registry deployed on interventional cardiology centers on the alpine arc is therefore also addressed to patients with senile cardiomyopathy. the data collected will provide a better understanding of the factors influencing the prognosis of senile cardiomyopathy and the prognostic contribution of the measurement of the ihpm will be evaluated.


Eligibility criteria:
inclusion criteria: * male or female patient, over 75 years old * social security affiliate * any patient with the diagnosis of cardiac amyloidosis after etiological evaluation in one of the 4 alpin arc interventional cardiology centers (grenoble university hospital, ghm grenoble, annecy hospital and chambéry hospital). * non opposition to participation exclusion criteria: * concomitant ischemic cardiopathy with revascularization following cardiac scintigraphy exploration and subsequent coronary angiography. * concomitant non-amyloid non-ischemic cardiopathy (valvular cardiopathy) * major non-cardiac illness (eg, disseminated malignancy, severe neurological dysfunction at the time of diagnosis) or social condition that may preclude participation in a research study * major patient protected by law (article l1121-8) * person deprived of liberty (article l1121-8)