Kornimate/medical-research-clean huggingface dataset:
pilot atrial fibrillation information technology trial

Conditions: Atrial Fibrillation

Summary: af is associated with significant social and medical costs, including diminished quality of life (qol) and increased health care utilization (hcu). this pilot study will enroll 200 adults with prevalent, non-valvular af of ≤3 year's duration at university of pittsburgh medical center (upmc). the primary objective at present is to obtain extensive feasibility and pilot data in implementing the embodied conversational agent (eca) in concert with the kardia (kac) heart rhythm monitor.

this pilot study is a single-center, two-arm randomized study that by design is unblinded. 200 total participants are planned. each participant will be randomized in an unblocked manner to receive "usual care" or the eca/kac intervention. participants will have study visits at baseline and time 30 days. adherence to using the eca/kac in combination over 30 days will be quantified. following participation study participants randomized to the eca/kac intervention will undergo an interview to determine their experience with the eca/kac. participants and their physicians will receive a summary of eca use and symptoms and correlated findings by kac.

Eligibility criteria:
inclusion criteria: * chads2-vasc score ≥2; english-speaking (at level appropriate to provide informed consent and participate in this research protocol); no plan to relocate from the area within 12 months of enrollment exclusion criteria: * af that is due to non-cardiac causes (e.g., sepsis, pneumonia, thyroid disorders, and intoxication); af within 30 days of any cardiothoracic or thoracic surgery; inability to complete training session with the smartphone and demonstrate use of the eca; inability to answer specific protocol-based questions correctly during consent.

Keywords: adherence quality of life health literacy
standardization of laparoscopic hernia repair

Conditions: Incisional Hernia

Summary: incisional hernias are one of the most frequent complications in abdominal surgery. laparoscopic repair is widely used but even not standardized. existing data from different study designs show no representative data resulting in a lack of comparability and evidence. therefore the standardization of operative techique has been proposed by the lipom-study group and will be assessed in a prospective manner.

data are scheduled for publication.

Eligibility criteria:
inclusion criteria: * primary incisional hernia * hernia size ehs w 1-2 * hernia location ehs m 1-5, l 1-3 * clinical symptoms or progressive growth of hernia exclusion criteria: * recurrent incisional hernia * ventral hernie * hernia size \> ehs w 2 * hernia location ehs l 4, asa \>3 * prospective mesh overlap \< 5 cm * malignant disease

Keywords: lapraoscopy, incisional hernia repair, mesh
study to investigate the relative bioavailability, influence of pantoprazole coadministration and food effect of different oral formulation of bi 113608

Conditions: Healthy

Summary: the objective of the trial is to investigate the relative bioavailability, influence of pantoprazole coadministration and food effect of different oral formulations of bi 113608 in healthy male subjects


Eligibility criteria:
inclusion criteria: 1. healthy male subjects exclusion criteria: 1. any relevant deviation from healthy conditions
does choice improve the pain relief derived from a brief intervention

Conditions: Pain; Acute Pain

Summary: this project is a single-site, four-arm, randomized controlled trial investigating whether providing patients in an orthopedic clinic waiting room the ability to choose which pain management intervention the receive impacts the degree of pain relief they experience.

this project is a single-site, four-arm, randomized controlled trial investigating whether providing patients in an orthopedic clinic waiting room the ability to choose which pain management intervention the receive impacts the degree of pain relief they experience. participants will be randomized to one of three conditions: 1) a 4-minute pain psychoeducation recording, 2) a 4-minute mindfulness recording, or 3) choice. in the choice condition, participants will be able to choose which recoding (i.e., pain psychoeducation or mindfulness) they would like to listen to.

Eligibility criteria:
inclusion criteria: * receiving pain treatment at tallahassee orthopedic center * understanding english instructions fluently * being 18 years of age or older exclusion criteria: * unable to consent because of physical or mental incapacity.

Keywords: mindfulness
itbs on negative symptoms and cognitive function in schizophrenia

Conditions: Schizophrenia

Summary: the negative symptoms and cognitive deficits are common in patients with schizophrenia, and do not respond well to antipsychotics. the effective treatments for negative symptoms and cognitive impairment are still to be explored. rtms is a safe and non-invasive physical treatment, some studies has been indicated that the high frequency rtms could increase the excitability of cortex, and has potentials to improve negative symptoms and cognitive function in schizophrenia. in this study, we explore the effects of itbs on negative symptoms and cognitive function based on identifying the brain network connection of schizophrenia symptoms.

the negative symptoms and cognitive deficits are two core symptoms in patients with schizophrenia, and do not respond well to antipsychotics. there are many researches on the biological mechanism of these two symptoms, and some studies indicated that these two symptoms maybe related to the dysfunction of prefrontal cortex and deficiency of dopamine. rtms is a safe and non-invasive physical treatment, some studies has been indicated that the high frequency rtms could increase the excitability of cortex, and has potentials to improve negative symptoms and cognitive function in schizophrenia.therefore, this study explore the efficacy of itbs on negative symptoms and cognitive deficits in schizophrenia based on identifying the brain network connection of schizophrenia symptoms. firstly, we have used neuroimaging to find the left prefrontal cortex that is responsible for negative symptoms and cognitive function in schizophrenia. then,we design this randomized double-blind sham-controlled clinical trial. patients with schizophrenia will be randomly treated with itbs or sham condition to the left dorsolateral prefrontal cortex(l-dlpfc) for continuous 10 days, thel-dlpfc will be targeted utilizing the localite neuronavigation system. the follow-ups are set at baseline, the 11th day and the 30th day after the end of treatment. the main outcome measures include the change in mccb score, panss score, sans score, saps score and the resting-state functional magnetic resonance imaging data.

Eligibility criteria:
inclusion criteria: 1. patients with schizophrenia in accordance with dsm-5 2. the disease duration ≤8 years 3. received a steady dose of antipsychotic medication for least 4 weeks 4. the global deficit score of mccb ≥0.5 or the panss negative subscore ≥20 5. no obvious extrapyramidal side effects caused by antipsychotic drugs 6. informed consent exclusion criteria: 1. diagnosed with other mental disease in accordance with dsm-5 2. combined with other severe physiological disease 3. used antidepressants, mood stabilizer, or other psychoactive substances before 4. drug or alcohol abuse 5. pregnant or lactating 6. contraindication to rtms 7. received rtms or electroconvulsive therapy in the past 1 month

Keywords: schizophrenia itbs negative symptom cognitive function
clinical significance of intra-abdominal hypertension in surgical patients with severe sepsis

Conditions: Bowel Perforation; Abscess; Leakage; Peritonitis; Pneumonia

Summary: * intra-abdominal pressure(iap) is defined as a steady state pressure of the abdominal cavity * many studies have proved iap as a prognostic factor that elevated iap influences hemodynamics and multiple organs dysfunction * in previous studies, most of them was based on the septic patients of medical diseases. and it is rare about sepsis of surgical diseases such as traumatized or postoperative patients * we hypothesized that intra-abdominal hypertension may affect clinical course such as length of stay of intensive care unit, weaning of mechanical ventilation, proceeding of enteral feeding and mortality * our study was aimed to investigate prevalence of iah and risk factors and to analyze clinical course and prognosis influenced by iah in surgical patients with severe sepsis

* inclusion criteria older than 18 diagnosed as severe sepsis agreed on informed consent * exclusion criteria refused to participate in the study traumatic injuries on urethra or bladder open abdomen status * definition of severe sepsis organ failure more than one organ with sepsis arterial blood lactate concentration of at least 4mmol/l hypotension with a systolic blood pressure lower than 90mmhg * definition of intra-abdominal hypertension intra-abdominal pressure more than 12mmhg * measurement of iap measuring via three lument urinary catheter measuring after filling with 25ml normal saline measuring in supine position at level of mid-axillary line on iliac crest measuring three times a day during icu stay

Eligibility criteria:
inclusion criteria: * older than 18-year * agreed on informed consent * diagnosed with severe sepsis exclusion criteria: * traumatic injuries on urethra or bladder * open abdomen status

Keywords: severe sepsis intra-abdominal hypertension intra-abdominal pressure
non-interventional study to evaluate arimidex in postmenopausal women with advanced breast cancer

Conditions: Advanced Breast Cancer

Summary: to evaluate arimidex 6 month therapy as an adjuvant treatment in postmenopausal patients with advanced breast cancer in whom a partial or complete response or stabilized disease were obtained with first line chemotherapy, by tumoral response assessment.


Eligibility criteria:
inclusion criteria: * patients to be included in the program are that ones according to the indications specified in the romanian anastrozole (arimidex) approved smpc (attached to the protocol)and who are already treated with anastrozole for at least 1 month before inclusion in this program/non-interventional study. exclusion criteria: * patients not to be included in the programme: patients who have a known hypersensitivity to anastrozole (arimidex®) or any of its excipients.

Keywords: advanced breast cancer advanced breast cancer in postmenopausal women
deeper intubation make effects on cervical esophageal esd

Conditions: Carcinoma in Situ of Cervical Part of Esophagus

Summary: to compare the efficacy and safety of intratracheal deep intubation with traditional intubation in endoscopic submucosal dissection for early esophageal cancer in the cervical esophagus, and to follow up and assess their short-term clinical outcomes.

forty patients with early esophageal cancer in the cervical esophagus scheduled for endoscopic submucosal dissection will be included. they will be randomly divided into two groups using sealed envelopes: approximately 20 patients in the intratracheal deep intubation group and 20 patients in the traditional intubation group. by comparing the operation time, perioperative complications, postoperative short-term complications, and other outcomes, we aim to elucidate the effectiveness and safety of deep intubation in endoscopic submucosal dissection for early esophageal cancer in the cervical esophagus.

Eligibility criteria:
inclusion criteria: 1. the lesions mainly involve superficial esophageal squamous cell carcinoma or high-grade intraepithelial neoplasia (hgin) in the cervical esophagus; 2. there is no evidence of regional lymph node or distant metastasis on endoscopic ultrasound (eus) or ct/mri imaging; 3. participants have a thorough understanding of this study and voluntarily sign the informed consent form. exclusion criteria: * 1. patients who have received radiotherapy or chemotherapy before endoscopic submucosal dissection surgery; 2. patients with severe comorbidities who are not suitable for endoscopic submucosal dissection surgery.

Keywords: deep tracheal intubation cervical esophageal cancer esd
the impact of a web-based psychoeducation programme with a motivational ai chatbot on covid-19 vaccine hesitancy

Conditions: Vaccine Hesitancy; COVID-19

Summary: vaccine hesitancy is defined as 'delay in acceptance or refusal of vaccines, despite the availability of vaccine service' and was named one of the top ten global health threats by the world health organization in 2019. our proposed study will aim to develop and evaluate the effectiveness of a web-based psychoeducation programme to address covid-19 vaccine hesitancy, 'ai-driven vaccine communicator' (including educational materials, animations of vaccine research and development, and an mi communication skills-based ai, digital assistant). our goal is to standardise our intervention so that it can serve as an effective toolkit for clinicians/healthcare providers to increase hong kong residents' motivation to vaccinate and to ensure that the programme can be adapted to viral mutations and newly developed vaccines in the medium/long term.

this study is a two-arm, single-blind pilot randomized controlled trial, and it will be adopted to evaluate the efficacy of the 'ai-driven vaccine communicator' relative to being self-informed about covid-19 vaccines. also, to address the widespread hesitancy among hong kong residents toward covid-19 vaccines, we will develop a web-based psychoeducation programme, 'ai-driven vaccine communicator,' driven by artificial intelligence (ai) techniques based on the vaccine hesitancy determinants matrix model and mi communication skills and concepts (theoretical underpinnings). after developing and piloting this programme, we will test its effectiveness among members of the population who are hesitant about covid-19 vaccines. the programme will then be refined further and standardised to use the most relevant information and effective communication skills to promote acceptance of covid-19 vaccines among a wider hong kong population. clinicians and healthcare providers will be able to utilise our programme as a toolkit in their usual practice when working with clients who are hesitant about covid-19 vaccines.

Eligibility criteria:
inclusion criteria: * 18 years or above; * hong kong residents; * show vaccine hesitancy (not taking covid-19 vaccines or receiving involuntary covid-19 vaccines); * have internet access * able to read chinese or english. recruitment involved social media promotion and collaborating with community organizations exclusion criteria: * people with self-reported cognitive impairments or mental disorders that might interfere with their understanding of the intervention content; * people who currently engaged in another clinical trial in relation to covid-19 vaccines.

Keywords: vaccine hesitancy covid-19 motivational intervention ai chatbot artificial intelligence
importance and association of gut microbiota and biochemical metabolites on children allergic disorder

Conditions: Allergic Disorder; Food Hypersensitivity; Food Allergy in Children

Summary: food allergies account for only a small percentage of all adverse reactions to foods and their prevalence has increased over the past 10-15 years, particularly in industrialized countries: 3-6% of children under 3 years of age and 1-3% of adults. food allergens in children are represented by milk, egg, wheat, soy, peanuts, tree nuts, fish, and shellfish. the majority of allergic processes that develop during the childhood tend to abate with age, whereas those that occur during adulthood tend to persist. hypersensitivity refers to an excessive immunological reaction to food antigens with undesirable consequences. the first aim of our study is to evaluate the role of intestinal microbiota and their relationship with immune tolerance or allergic disorder. the second aim of our study is determining the biochemical metabolites on the host (human being) in allergic disorder, and these biochemical metabolites can be measured in fecal or urine samples by metabolomics methods. we try to seek to gain an advanced understanding of gut microbiota and biochemical metabolites associated with mucosal immune responses in the host. these findings could be useful for developing strategies to modify the gut microbiota or medical applications (e.g. healthy microbe preparations) involving beneficial microorganisms to control the development of allergic disorders.

intestinal microbiota are directly involved in the development of innate and acquired mucosal immune response. the gut microbiota also have metabolic, synthetic, and processing functions in close liaison with the human body's metabolic processes. they are excellent energy anaerobic bioreactors, and they can consume, store, and redistribute the energy produced. the gut microbiota also allow us to extract energy from substances not otherwise useful in terms of energy, such as indigestible carbohydrates. intestinal microflora are able to use the substances consumed in the diet: bacteria can transform complex polysaccharides and monosaccharides in short-chain fatty acids. short-chain fatty acids are a source of energy for colonocytes and directly affect the storage of lipids and the absorption and metabolism of food, creating the so-called 'second meal effect'. qualitative and quantitative alterations of commensal flora may result in various gastrointestinal and extraintestinal diseases. food hypersensitivity and allergies are an emerging entity in the microbial related diseases universe.

Eligibility criteria:
inclusion criteria: children with immune tolerance; children with food hypersensitivity children with food allergy children with allergic disorder healthy volunteers (children) exclusion criteria: exclusively vegetarian was not enrolled in this study. -

Keywords: food sensitization food hypersensitivity food allergy
effects of obesity on copd

Conditions: COPD; Obesity; Chronic Obstructive Pulmonary Disease

Summary: the purpose of this study is to investigate whether obese copd patients experience more or less discomfort in daily life. furthermore the investigators will evaluate if body composition or body fat distribution has effects on symptoms and performance.

chronic obstructive pulmonary disease (copd) and obesity are two major health problems. the prevalence of both is growing and there is a complex interaction between copd and obesity. on the one hand obesity impairs lung function, with decreasing static lung volumes being the most significant effect. on the other hand there seems a beneficial role of obesity on lung function in copd patients. this is because obese copd patients tend to have less hyperinflation than non-obese copd patients . an interesting question is what the net effect of these changes in lung function is on respiratory symptoms and quality of life. in this observational study, the investigators will compare obese and non-obese copd patients. pulmonary function, dyspnea and quality of life will be compared between the two groups.

Eligibility criteria:
inclusion criteria: * diagnosed with copd by a pulmonologist defined as an obstructive lung function test with fev1/fvc \< 0.7 and fev1 \< 80% predicted * no exacerbation of copd at time of inclusion * age \> 18 years * able to perform lung function tests and fill in the questionnaires. exclusion criteria: * not able to perform lung function tests or fill in the questionnaires * diagnosis of asthma * diagnosis of neuromuscular disease * diagnosis of heart failure * treatment for lung malignancy in the past * active malignancy

Keywords: copd obesity chronic obstructive pulmonary disease dyspnea hrqol symptoms dynamic hyperinflation
validity of scales to assess severity in acute heart failure

Conditions: Heart Failure

Summary: the scales measuring the severity of acute decompensate heart failure (adhf) in emergency departments have not achieved an adequate discriminative ability for decision making. objectives: 1) identify baseline variables, and evolutionary variables that may provide a good predictive ability of the model.2) create and validate clinical predictive rules of mortality during admission/a week after ed visit in those discharged from ed, 30 and 60 days after ed visit as well as identify predicitive factors of short-term readmission (90 days)design: prospective cohort study. the sociodemographics and clinical variables will be collected from emergency medical records to identify predictors. outcome variables and evolution of variables will be collected from hospital medical records / ambulatory during admission and up to 90 days after the episode of adhf. baseline predictors and evolutionary variables will be identified through logistic regression models using 60% of the final sample. the models that best fit will be applied in 40% of the sample to assess the predictive validity of this scale.


Eligibility criteria:
inclusion criteria: * they were diagnosed as heart failure) hf is defined, clinically, as a syndrome in which patients have typical symptoms (e.g.breathlessness, ankle swelling, and fatigue) and signs (e.g. elevated jugular venous pressure, pulmonary crackles, and displaced apex beat) resulting from an abnormality of cardiac structure or function.(8) we included the following presentation of acute heart failure (ahf) at ed: acute decompensated heart failure, hypertensive acute heart failure, pulmonary oedema, cardiogenic shock, and high output failure. (9;10) exclusion criteria: * patients whose main diagnosis in the er is different than acute heart failure and those not wishing to participate in the study or signing the informed consent.