Kornimate/medical-research-clean huggingface dataset:
evaluation of healing at molar extraction sites with and without ridge preservation

Conditions: Loss of Teeth Due to Extraction

Summary: following tooth extraction ridge preservation procedure have been suggested to limit bone resorptive dimensional changes to facilitate prospective implant placement. while this is particularly true for anterior teeth, no evidence is available to establish clinical guidelines in posterior sites, i.e. following molar extraction. this research project will answer the following question: what are the dimensional changes of the hard and soft tissues encountered following molar extractions with and without ridge preservation?


Eligibility criteria:
inclusion criteria: * patients will be included in this study if they qualify the following inclusion criteria: * one molar tooth that has been identified by dental faculty as requiring a single tooth extraction * a dental implant is indicated and treatment planned to replace the missing molar tooth * have adequate restorative space for a dental implant-retained restoration * have at least 10mm of alveolar bone height, without impinging on the maxillary sinus or inferior alveolar canal. exclusion criteria: * obvious exclusions are patients who do not meet all the inclusion criteria or who will not cooperate with the follow-up schedule. * patients will not be entered who are mentally incompetent, prisoners, or pregnant. * pregnant women or women intending to become pregnant during the study period. as standard practice prior to dental surgery, females of child-bearing age are asked verbally if there is any possibility that they are pregnant. if not, we proceed with surgery and no pregnancy test is done. if the woman states that there is a possibility that she is pregnant, we do a urine pregnancy test to rule pregnancy in or out. so use of the urine pregnancy test is only done if she says she may be pregnant. \[if needed: an over-the-counter urine pregnancy test will be provided to female subjects in the graduate periodontics clinic of uthscsa. patients will be allowed access to a private restroom and the results of the tests will be read by one of the named investigators. only those with a negative pre-operative pregnancy test will be eligible for the study.\] female patients who have undergone a hysterectomy, tubal ligation or menopause will be excluded from pregnancy testing. * patients who become pregnant during the study will be withdrawn and standard care will be delivered. * clinical and/or radiographic determinations which will preclude inclusion in this study are: * active localized or systemic infection other than periodontitis. * untreated periodontal diseases * inadequate bone dimensions or restorative space dimensions to place a dental implant * presence of a disease entity, medical condition or therapeutic regimen which decreases probability of soft tissue and bony healing, e.g., poorly controlled diabetes, chemotherapeutic and immunosuppressive agents, or autoimmune diseases. * positive medical history of endocarditis following oral or dental surgery.
case-control study of fibrotic interstitial lung disease (ild) and cardiac disease / interventions.

Conditions: Idiopathic Pulmonary Fibrosis; Interstitial Pneumonia

Summary: there is a rare condition causing scarring of the lungs termed interstitial lung disease. this comprises a group of conditions which can be divided into separate diseases. the aim of this study is compare a group of patients (the cases) with 2 types of this disease (fibrotic non-specific interstitial pneumonia (nsip) and idiopathic pulmonary fibrosis (ipf)) with patients without the disease. the study will look at the 2 groups and their exposures to factors such as medications, smoking, previous jobs, previous medical problems and specifically heart disease and any operations or procedures involving the heart. there have been previous studies showing a link between heart disease and scarring of the lungs. this study will look at whether this association is stronger in one or the other type of lung scarring diseases.


Eligibility criteria:
inclusion criteria: * idiopathic fibrotic lung disease exclusion criteria: * non idiopathic fibrotic lung disease

Keywords: non-specific interstitial pneumonia
chilean maternal & infant cohort study ii (chimincs-ii)

Conditions: Breast Density; Body Composition; Nutritional Status; Mental Health Issue

Summary: the chilean maternal \& infant cohort study ii (chimincs ii) is an ongoing cohort that is part of the chilean maternal and infant nutrition observatory of the south-east area of santiago, chile. in total, 1927 pregnant women beneficiaries of the public health systems and their offspring were recruited before 12 weeks of gestation and are followed across pregnancy (\<15, 26-28, and 35-37 weeks of gestation) and up to 2 years of age of their offspring. two studies are currently nested in chimincs ii: 1) breast cancer risk assessment in mothers (brecam) study, and 2) the chimincs-covid study. the primary objective of brecam study is to test the association between maternal metabolic indicators (i.e., insulin, glucose, igf-1, and hbac1 concentrations) at early pregnancy (i.e., \<15 and 26-28 weeks of gestation) and breast density 3 months after the cessation of lactation. for this purpose, we collect maternal obstetric, lifestyle, dietary intake, anthropometric, and biochemical information. the aim of the chimincs-covid study is to assess dietary-related risks and mental health problems derived from the covid-19 pandemic and their influence on maternal and infant's health and nutrition. thus, we collected detailed information on dietary behaviors, mental health and covid-related information at each trimester, along with neonatal and infant nutritional information. the purpose of the present work is to describe the design, methods, and descriptive information at recruitment of chimincs-ii, also discussing the implications that this study can have to better understand maternal and infant nutrition and health during the covid-19 era.


Eligibility criteria:
inclusion criteria: * 18 or more years of age * gestation \<15 weeks at first prenatal visit * no intention to move outside the city of santiago in the next to years exclusion criteria: * high-risk pregnancy (i.e., preeclampsia, pre- existing diabetes) * pre-existing cancer or family history of breast cancer * intended to migrate from the public to the private health care system

Keywords: breast densities breast neoplasms glucose metabolism disorders diabetes, gestational pregnancy nutritional status mental health body composition growth and development primary health care dual-energy x-ray absorptiometry latin america chile
minimally invasive surgery in total knee arthroplasty

Conditions: Osteoarthritis of the Knee

Summary: overall study design: a prospective, randomized, multi-center clinical studies comparing the minimal invasive and the standard surgical total knee replacement technique (control) using the genesis ii total knee system. the study will collect efficacy, safety and socio-economical data over 2 years. an additional 5 years follow-up interval is optional. the objectives (short-term follow-up) of the study are to: 1. assess whether the improvement in pain and range of motion per knee society scoring system and vas score. 2. assess whether there are any differences between the surgical techniques as regards complication rate. 3. assess whether the hospital stay and the rehabilitation time (straight leg raise, active/passive rom) of the patients differs between the two techniques. 4. assess the x-ray mechanical alignment between the two techniques. attempts will be made to assess whether the collected peri-operative data (including incision length, blood loss, wound appearance, hospital readmissions and operative time) differs between the two surgical techniques. the primary objectives (mid-term follow-up) of the study are to: 1. improvement in pain and function per knee society scoring system 2. number and extent of radiographic lucencies \>2mm 3. revision and knee-related adverse events 4. improvement in quality-of-life via the vas score 5 investigational sites will participate and enroll a total of approximately 250 patients over a 12 months period. thus, each site will enroll 50 patients.


Eligibility criteria:
inclusion criteria: * require primary uni- or bilateral total knee arthroplasty; available for 2 year follow up; provide informed consent; is in stable health for cardio-pulmonary conditions. exclusion criteria: * inefficient femoral or tibial bone stock; bmi \>35; fixed flexion deformity \>15 degrees; knee flexion of \ 20 degrees; active local infection; conditions that would compromise the 2 years follow up.

Keywords: primary osteoarthritis of the knee.
evaluate the efficacy and safety of meditoxin in treatment of primary axillary hyperhidrosis

Conditions: Hyperhidrosis Primary Focal Axilla

Summary: this study is intented to evaluate the efficacy and safety of meditoxin compared to placebo in treatment of primary axillary hyperhidrosis.


Eligibility criteria:
inclusion criteria: * adult patients aged from 20 to 65, with persistent bilateral primary axillary hyperhidrosis exclusion criteria: * those who have secondary hyperhidrosis * those who have systemic neuromuscular junction disorders * women who are pregnant or lactating
prospective cohort study on multidisciplinary approach to femur fractures' management in over 65 population

Conditions: Hip Fractures; Intertrochanteric Fractures; Femur Fracture

Summary: hip fractures are an increasing public health concern as the population continues to age. the increased morbidity and mortality in the 12-month period after hip fracture is largely related to decreased mobility. however, very few studies have analyzed the radiographic factors associated with gait impairment after intertrochanteric hip fractures. this study evaluates gait and mobility after surgical fixation of it fractures in elderly population with gait analysis in combination with clinical and radiographic information.

hip fractures are an increasing public health concern as the population continues to age. the increased morbidity and mortality in the 12-month period after hip fracture is largely related to decreased mobility. however, very few studies have analyzed the radiographic factors associated with gait impairment after intertrochanteric (it) hip fractures. improving gait and mobility after surgical fixation of it fractures is one important target of research efforts. all the patients with it hip fractures (ao/ota 31) treated between october 2017 and april 2018 were enrolled. inclusion criteria consisted of age older than 65 years, previous walking ability, no neurological disease and no other musculoskeletal disorders. the study was approved by the institutional review board of the local ethical committee (reference number 5559). all patients provided written informed consent for participation in the study. all patients were treated with intramedullary nailing (imn) or hemiarthroplasty (ha) according to the current international guidelines and to their clinical history. radiographs were analyzed at the time of surgery and at each follow-up visit. clinical outcomes were assessed according to the harris hip score (hhs) and western ontario and mc master university (womac). at 6- and 12-months follow-up appointments, gait parameters were measured and recorded in our gait analysis laboratory (bts bioengineering spa, italy) located in aouc policlinico di bari (rehabilitation unit). all participants performed several walking trials at their natural speed. all patients were fitted with full-body external reflective markers placed according to davis' procedures. a static video trial was recorded with subjects positioned in a neutral standing posture to create a reference for defining neutral joint angles. in addition, at 12-months follow-up, dual energy x-ray absorptiometry (dxa) has been acquired in order to collect t-score data. statistical analyses were performed using ibm spss version 23. a p value of \<0.05 was considered to be statistically significant.

Eligibility criteria:
inclusion criteria: * age older than 65 years * previous walking ability * surgical procedure (intramedullary nailing or hemiarthroplasty) exclusion criteria: * neurological diseases * musculoskeletal disorders * cardiovascular diseases

Keywords: gait analysis hip fracture elderly mobility
biomolecular messages associated with the differentiation of human induced pluripotent stem cells to skeletal muscle progenitor cells

Conditions: Female Urinary Incontinence and Pelvic Organ Prolapse

Summary: female urinary incontinence and pelvic organ prolapse are common diseases especially in aged women that frequently cause urogenital infection, voiding difficulty, urinary retention, pelvic pain, constipation, and coital difficulty, as well as impact the quality of life of women. risk factors of the above diseases include pregnancy, vaginal delivery, and menopausal status. despite playing a crucial role in the pathophysiology of the above diseases, the urogenital skeletal muscular dysfunction cannot be fully corrected via the current treatment modalities. the human induced pluripotent stem cells (hipscs) represent a prime candidate cell type for current research and future cell therapy because of their significant self-renewal, differentiation potential and the relative lack of ethical conflict. with the advent of efficient technology of reprogramming peripheral blood mononuclear cells (pbmcs) into hipscs, researchers can generate personalized lines of cells from which it will be possible to obtain differentiated cells in a less invasive way, introducing opportunities in treating diseases that are now considered incurable. until very recently, little success has been achieved in terms of skeletal muscle differentiation from hipscs. the purpose of this study is to explore the applicability of the differentiation into skeletal muscle progenitor cells from hipsc cell lines and the associated biomolecular messages. it is anticipated that the derived skeletal muscle progenitor cells can be reprogrammed from pbmcs of female patients with urinary incontinence and/or pelvic organ prolapse and used in preclinical testing for relieving female urogenital problems.


Eligibility criteria:
inclusion criteria: * human induced pluripotent stem cells, hipscs exclusion criteria: -
compassion training and pain

Conditions: Chronic Pain

Summary: the purpose of this study is to determine whether compassion training will improve the physical and psychological well-being of patients with chronic pain. the investigators also want to determine whether any benefit of compassion training in the patients "spreads" to significant others with whom the patient has a close relationship.


Eligibility criteria:
inclusion criteria: 1. age 18+ and chronic pain for \>6months 2. pain over the last month 3. ability to read, write, and converse in english 4. if being treated for pain condition, then stable treatment regimen. for significant others: 1)18 years of age or older 2)ability to read, write, and converse in english exclusion criteria: for patients and significant others: 1)current or history of a psychological disorder that would interfere with study procedures, at the discretion of the researcher. for patients only: 1. prior compassion meditation experience 2. on going legal action or disability claim 3. currently pregnant or planning to become pregnant
ultrasound-guided intermediate cervical block versus superficial cervical block for carotid endarterectomy (cervecho)

Conditions: Carotid Atherosclerosis; Regional Anaesthesia Morbidity

Summary: the aim of this prospective, randomised, controlled study is to compare the efficacy of ultrasound-guided intermediate cervical block to superficial block for carotid endarterectomy. patients scheduled for carotide endarterectomy under regional anaesthesia (ropivacaine 4.75 mg/ml) are randomised into 2 groups according to the technique of anaesthesia performed: superficial cervical block (control group) or, ultrasound guided intermediate cervical block (echo group). main outcome is cervical block success, defined by surgery performed under regional anaesthesia without supplemental topical lidocaine. secondary outcomes are rate of conversion to general anaesthesia, total dose of supplemental topical lidocaine and block-related complications.


Eligibility criteria:
inclusion criteria: * patient scheduled for elective carotid artery endarterectomy under regional anaesthesia exclusion criteria: * indication for general anaesthesia * known bleedind diathesis * past medical allergy to local anaesthesic * severe chronic pulmonary disease * contralateral diaphragmatic motion abnormalities * previous cervical ipsilateral surgery * age \< 18 years

Keywords: ultrasound-guided regional anaesthesia cervical block
treatment drop-out and missed appointments among adults with adhd

Conditions: Attention-Deficit/Hyperactivity Disorder; Drop-out; Non-adherence

Summary: the investigators knowledge of factors associated with treatment drop-out and missed appointments among adults with attention-deficit/hyperactivity disorder (adhd) within a naturalistic, clinical setting is very limited. drop-out rates among adult adhd patients in randomised controlled trials (rct´s) have been reported to be 26.6% - 50%, and similar rates are reported in two naturalistic studies of medication adherence. based on proposed hypotheses that past behaviour patterns are more predictive of current behaviours of treatment drop-out and missed appointments than are sociodemographic and clinical characteristics, the aim of the present study is to examine the associations of 1) sociodemographic variables, 2) clinical variables, 3) risk-taking behaviour 4) educational and occupational instability and 5) behaviours during primary/lower secondary school with treatment drop-out and number of missed appointments. the target group of the study consists of all patients who initiates assessment at the adult adhd clinic at regional psychiatric services west, herning, central denmark region in the period from september 1, 2010 to september 1, 2011. the patients are referred to this clinic from general practitioners and specialised psychiatric authorities. the investigators study is designed as an observational, cohort study in which the patients are offered medical and non-manualised psychosocial treatment as it is usually offered in this tertiary adhd clinic from which the data are collected. data regarding sociodemography, clinical symptoms and impairments, risk-taking behaviour, educational and occupational instability and behaviours during primary/lower secondary school are collected using a semistructured protocol. in the investigators study the investigators define treatment drop-out as premature termination of ongoing treatment, without any prior clinical or agreed resolution. no standardized definition of treatment drop-out is used through out the literature of adherence to treatment among patients in the psychiatric care system.


Eligibility criteria:
inclusion criteria: * referred to the adhd clinic and initiating assessment between september 1, 2010 and september 1, 2011 exclusion criteria: * no adhd diagnosis as assessed by the adhd clinic

Keywords: adults outpatients
tbe seropersistence up to 10 years after first booster in adults

Conditions: Tick-borne Encephalitis (TBE)

Summary: the purpose of this study is to evaluate tbe antibody persistence from 7 to 10 years after the first booster tbe vaccination with fsme-immun 0.5ml.


Eligibility criteria:
inclusion criteria: subjects who participated in the first and second precursor studies will be eligible for participation in this study if: * they understand the nature of the study, agree to its provisions and provide written informed consent * they received the first booster vaccination with fsme-immun 0.5ml during the first precursor study and did not receive a second booster vaccination in the second precursor study * blood was drawn after their first booster vaccination in the first precursor study exclusion criteria: subjects will be excluded from participation in this study if they: * received any tbe vaccination since their first booster vaccination with fsme-immun 0.5ml * have a history of infection with or vaccination against other flaviviruses (e.g. dengue fever, yellow fever, japanese b-encephalitis) since their first booster vaccination with fsme-immun 0.5ml * are known to be hiv positive since their first booster vaccination with fsme-immun 0.5ml * have a known or suspected problem with drug or alcohol abuse
study of the efficacy and safety of bp101 in female patients with decrease or loss of sexual desire

Conditions: Hypoactive Sexual Desire Disorder (HSDD)

Summary: this is study of the efficacy, safety and pharmacokinetics of bp101 compared to placebo in patients with a decrease or loss of sexual desire.


Eligibility criteria:
inclusion criteria: * women aged 21 or older, who have signed informed concent, with a regular menstrual cycle (straw stages -5 to -3 (see annex 7)). * the level of follicle-stimulating hormone (fsh) is not more than 25 milli-international unit per ml (miu/ml) according to the screening values. * decrease or loss of sexual desire (icd-10 code: f-52.0) corresponding to the hypoactive sexual desire disorder (hsdd) diagnosed according to diagnostic and statistical manual of mental disorders, 4th edition (dsm4), criteria. * current hsdd episode lasting not less than 24 weeks. * patients with secondary female sexual arousal disorder (fsad) and/or female orgasmic disorder (fod) will be eligible only if the hsdd developed before the fsad and/or fod and the hsdd has a more significant impact on the patient's quality of life. * not less than 15 scores according to the fsds-r (distress) total score. * stable monogamous relationship with one sexually active male sexual partner lasting at least a year. the partner is physically available not less than 50% of time during a month. * consent to attempt to have a sexual intercourse at least twice a month, if she has a desire. * consent to complete a diary every day during the screening period and assessment of the baseline state (in this period diary records must cover ≥80% days), during the therapy and subsequent follow-up. * consent to use adequate methods of contraception throughout the study. exclusion criteria: * any prohibited treatments. * other mental disorders or psychiatric diseases. * score ≥ 20 according to the beck depression inventory during the screening. patients with 16 to 19 scores according to beck's inventory may be included in the study unless, in the investigator's opinion, an actual depressive disorder is observed in the patient. * inflammatory diseases of pelvic organs, infections of the genitourinary system, cervicitis, interstitial cystitis, vulvodynia or severe atrophy of the vaginal epithelium. * surgical interventions (other than cosmetic surgeries) on reproductive organs in past medical history (ovariectomy, hysterectomy, obvious scars from childbirth-related perineal stitches, etc). * pregnant and nursing women or non-lactating women during the first 12 months after childbirth. * consumption of more than 5 portions of alcoholic drinks per week or alcohol addiction, drug addiction or drug abuse in the past. one portion of an alcoholic drink means 360 ml of beer, 120 ml of wine or 30 ml of a strong alcoholic drink.