cartography and quantitative characterization of achilles tendon fibrocartilage by te = 0ms imaging at 3t mri

Conditions: Spondyloarthropathy; Tendinopathy

Summary: the purpose of this study is to accurately map calcaneal fibrocartilage using te = 0 ms imaging, and then apply measurements of our control population to spa patients with peripheral enthesis study using the calcaneal tendon as a clinical model

the human body contains a lot of tissue components with short t2 (transversal relaxation time) that are not or only poorly detected on conventional t2-weighted mr sequences. these components are mostly located in musculoskeletal organs such as tendons, ligaments, menisci, periosteum or cortical bone. considering that conventional sequences do not detect tissue components with t2 shorter than 10ms, imaging of body tendon or enthesis is therefore very limited. this represents a limitation of mr imaging in early diagnosis of a certain number of pathologies, such as mechanical or mostly inflammatory tendinopathy or enthesopathy. this study, would provide the feasibility of zte 2 sequence to quantitatively assess normal and pathological spondyloarthropathy achilles tendon enthesis at 3 t, and would demonstrate that this sequence allows the detection of spa enthesopathy prior to conventional sequences and enables disease monitoring. for those purposes, during inclusion visit sequences zte 2 and ute (with and without gadolinium injection) will be add to routine macrocyclic gadolinium injected mri of 3 groups of patients (symptomatic and non sympatomatic spondyloarthropathy and mechanical tendinopathy). healthy volunteer group will undergo an mri exam without gadolinium injection comprised of following sequences t2 fs, t1, dp fs, zte 2 and ute. no follow up visit are schedule in this study

Eligibility criteria:
inclusion criteria: * age ≥18 years, * covered under social security * informed signed consent additional criteria for each group: group 1: healthy volunteers * absence of diagnosis of spondyloarthropathies * no previous history of plantar support and pain, calcaneal tendinopathy, infiltration or surgery group 2: spa + non-symptomatics at the calcaneen fibrocartilage level * asas criteria axial or appendicular * no previous history of plantar support and pain, infiltration or surgery * prescription achile's tendon mri with injection of contrast agent (macrocyclic gadolinium) in usual care. group 3: spa + symptomatics at the calcaneen fibrocartilage level * asas criteria axial or appendicular * clinical suspicion of rheumatic enthesopathy * absence of a history of calcaneal infiltration or surgery * prescription achile's tendon mri with injection of contrast agent (macrocyclic gadolinium) in usual care. group 4: mechanic tendinopathy * clinical diagnosis of calcaneal mechanical tendinopathy * absence of diagnosis of spondyloarthropathies * no any previous history of plantar support disorder, calcaneal infiltration or surgery * prescription achile's tendon mri with injection of contrast agent (macrocyclic gadolinium) in usual care. exclusion criteria: * age less than 18 yrs old * pregnant or lactating woman * history or presence coronary pathology * septic arthritis * immunodeficiency. * contra-indication for mri exam * legal protection additional criteria for groups 2, 3 and 4: * history or presence of renal insufficiency * allergy to macrocyclic gadolinium

Keywords: spondylarthropathy tendinopathy mri healthy volunteer