Kornimate/medical-research-clean huggingface dataset:
study of percutaneous coronary intervention in left main coronary artery disease in patients with acute coronary syndrome at sohag university hospitals

Conditions: Left Main Coronary Artery Disease With Acute Coronary Syndrome

Summary: acute coronary syndromes (acs) encompass a spectrum of cardiovascular disorders characterized by the sudden onset of myocardial ischemia. they are primarily caused by atherosclerotic plaque rupture or erosion, leading to partial or complete occlusion of the coronary arteries. among the various coronary arteries affected, left main coronary artery disease (lmcad) is of particular concern due to its high anatomical significance and potential for adverse outcomes the left main coronary artery (lmca) is responsible for supplying a substantial portion of the left ventricular myocardium, including the interventricular septum and the anterior and lateral walls. any obstruction or compromise in blood flow within this critical artery can have severe consequences, including myocardial infarction, heart failure, or even sudden cardiac death. the management of lmcad associated with acs represents a significant clinical challenge, necessitating prompt and optimal treatment strategies among the various coronary arteries affected by atherosclerosis, left main coronary artery disease (lmcad) holds particular clinical significance due to its anatomical location and the vital role it plays in supplying a substantial portion of the left ventricular myocardium. the left main coronary artery (lmca) typically bifurcates into the left anterior descending artery (lad) and the left circumflex artery (lcx), which together provide blood supply to the majority of the left ventricle, including the interventricular septum and the anterior and lateral walls the selection of an appropriate treatment strategy for lmcad associated with acs is a complex decision that requires careful consideration of multiple factors, including patient characteristics, coronary anatomy, severity of ischemia, and procedural expertise. the emergence of several clinical trials and observational studies exploring the efficacy and safety of different revascularization strategies has further complicated the decision-making process


Eligibility criteria:
inclusion criteria: * age \> 18 years. * acute coronary syndromes (acs). * left main coronary artery disease (lmcad) on ca. exclusion criteria: * patients with contraindications to coronary angiography or invasive procedures. * prior history of percutaneous coronary intervention (pci) with left main stenting. * known allergy or intolerance to the medications or devices commonly used during pci procedures. * severe comorbidities or conditions that may limit life expectancy or impact the ability to follow the study protocol. * pregnancy or lactation. * refusal to participate * contra indication to antiplatelet.
randomized trial of fresh frozen plasma versus albumin in acute burn resuscitation

Conditions: Burns

Summary: the investigators propose a prospective randomized trial to study fresh frozen plasma (ffp) versus albumin to determine the optimal colloid in burn resuscitations. this work addresses both fy20 focus areas, prolonged field care (pfc) and en route care, along with mitigating secondary effects of acute intervention, such as prevention of over resuscitation. future military conflicts anticipate more extensive burn and blast injuries, and delayed evacuation. therefore, the direct comparison of colloids used in burn resuscitation is critical to advancing battlefield medicine. specifically, this work will provide the foundation for the use of freeze-dried plasma (fdp) in burn care by medical responders in pfc and en route care scenarios. the investigators hypothesize that ffp administration, and later fdp, in burn resuscitation is as safe as albumin, and more efficacious, in both reducing the total volume of fluid required in acute burn resuscitation and correcting burn endotheliopathy.

specific aim 1: the investigators will evaluate the total fluids administered in ffp (intervention) and albumin (control) groups. the investigators propose that the ffp group will require less total fluids administered. specific aim 2:the investigators will determine overall complication rates (pulmonary complications, ards, acs, over-resuscitation) in the ffp (intervention) and albumin (control) administration groups. the investigators propose ffp administration will reduce the frequency of these complications. specific aim 3: the investigators will characterize the effects of ffp and albumin administration on endothelial dysfunction in major burns. we will measure glycocalyx degradation products (e.g. syndecan-1, glycosaminoglycans) in the serum. the investigators project ffp will mitigate gdp better than albumin.

Eligibility criteria:
inclusion criteria: * adult thermal injury patients aged 2:18 years old with burns -\>20% tbsa seen at uch burn center within 8 hours of burn injury exclusion criteria: * pregnant patients, prisoners, jehovah's witness/inability to receive human blood product/component therapy, electrical injury, chemical injury, friction/shear injury, anticipated death within 48 hours of admission, delayed intervention (\>8 hours post burn), history of renal failure requiring dialysis, stage iv or v chronic kidney disease, coagulopathy (admission inr \>2.5), cirrhosis (childs b,c), concomitant life threatening traumatic injuries, receiving blood product transfusion for another reason, inability to obtain consent from patient or legally authorized representative.

Keywords: burn resuscitation
allopregnanolone for mild cognitive impairment due to alzheimer's disease or mild ad

Conditions: Mild Cognitive Impairment; Alzheimer Disease

Summary: the purpose of this study is to evaluate the safety and tolerability of allopregnanolone, a naturally occurring brain steroid, in mild cognitive impairment and early alzheimer's disease participants. the primary goal is to determine the maximally tolerated dose.

1) each dose group will be comprised of 8 participants (6 randomized to allopregnanolone; 2 randomized to placebo) administered one dose of allopregnanolone or placebo once per week for 12 weeks. a higher dose will be administered to the next group of participants when the lower dose is shown to be safe and tolerable. 2) pharmacokinetic analyses will be conducted on blood samples taken from participants at the beginning and end of the trial. 3) the trial will assess safety including via mri brain imaging.

Eligibility criteria:
inclusion criteria: * men or postmenopausal women * 55 years of age or older * diagnosis of mci due to ad or mild ad * mmse \> 20 at screen * capacity to provide informed consent * residing in the community with a caregiver able to accompany the patient to clinic visits * no medical contraindications to participation * willingness to comply with study procedures exclusion criteria: * use of benzodiazepines, sedative/hypnotics, anticonvulsants, antipsychotics, and other drugs that might interact with the gaba-a receptor complex * seizure disorder, history of stroke, focal brain lesion, traumatic brain injury, substance abuse, malignancy * clinically significant laboratory or ecg abnormality * mri indicative of any other significant abnormality, including but not limited to evidence of a cerebral contusion, encephalomalacia, aneurysms, vascular malformations, subdural hematoma, or space occupying lesions * any condition that would contraindicate an mri such as the presence of metallic objects in the eyes, skin, heart, or body

Keywords: alzheimer's disease mild cognitive impairment dementia regenerative therapeutic
safety and efficacy study of non-surgical mc device for adolescent male population including contraindicated subjects

Conditions: Circumcision, Adolescents

Summary: a new male circumcision (mc) device, prepex, has shown great promise as a way to radically shift the mc landscape. prepex is an innovative circumcision device requiring no injected anesthesia, sutures, or sterile settings. moreover, it is designed for use by minimally skilled healthcare professionals rather than surgeons. two initial studies conducted in rwanda in 2010 and 2011 demonstrated an excellent safety profile when the procedure was performed by skilled physicians

rwanda has also completed a third study to assess the safety and efficacy of mc when performed by nurses using prepex in both rural and urban hospitals, device safety was assessed by the rate of clinical adverse events and device-related incidents attributed to the prepex device and its procedures, the study report was shared with the who male circumcision technical advisory group. on february 2011 the who provided rwanda with recommendation to phase in mc scale up with the prepex device on adults. moreover the who recommended rwanda to study the prepex for use on adolescent population, starting on ages 15-17 and thereafter on ages 12-14 and 10-12.

Eligibility criteria:
inclusion criteria: * adolescent males in ages - 10 to 17 years * uncircumcised * subject wants to be circumcised * subject assent to the procedure * legal guardian consent to the procedure * subject with or without the following conditions: preputial adhesions and /or narrow foreskin/phimosis * able to understand the study procedures and requirements * agrees to abstain from sexual intercourse for 8 weeks after circumcision * agrees to abstain from masturbation for at least 2 weeks after removal * agrees to return to the health care facility for follow-up visits (or as instructed) after his circumcision for a period of 7 weeks post removal (8 weeks total) * subject able to comprehend and freely give informed consent for participation in this study and is considered by the investigator to have good compliance for the study * subject agrees to anonymous video and photographs of the procedure and follow up visits. exclusion criteria: * legal guardian withholds consent * active genital infection, anatomic abnormality or other condition, which in the opinion of the investigator prevents the subject from undergoing a circumcision * subject with the following diseases/conditions: paraphimosis, warts under the prepuce, torn or tight frenulum, hypospadias, epispadias * known bleeding / coagulation abnormality, uncontrolled diabetes * subject that to the opinion of the investigator is not a good candidate * subject does not agree to anonymous video and photographs of the procedure and follow up visits.

Keywords: prepex, male circumcision, hiv prevention, adolescents
a study of treatment patterns and outcomes in participants with stage iiia melanoma receiving adjuvant systemic therapy

Conditions: Melanoma

Summary: the purpose of this study is to examine real-world data among participants with stage iiia melanoma initiating nivolumab as adjuvant treatment in the community practice setting by utilizing patient data from the united states oncology network (uson) iknowmed (ikm) electronic health records (ehr) database.


Eligibility criteria:
inclusion criteria: * participants diagnosed with stage iiia melanoma during identification period * participants underwent sentinel lymph node biopsy (slnb) (index-event) during identification period * participants with a complete surgical resection at or following slnb during the identification period * participants received nivolumab, pembrolizumab or dabrafenib/trametinib as adjuvant therapy in uson post-index event during the identification period (i.e., within 12 weeks of slnb/resection); or received no treatment during the index period * participants receiving care at a uson site utilizing the full ehr capacities of the ikm database at the time of treatment * participants with ≥2 visits within the uson during the observation period * participants ≥18 years of age at first clinical diagnosis of melanoma exclusion criteria: * participants with a previous systemic therapy prior to index * participants with a diagnosis of ocular or uveal melanoma during the study period * participants with a previous nonmelanoma cancer without complete remission for more than 3 years prior to index * participants with mucosal or acral melanoma during the study period * participants with systemic use of glucocorticoids during at the initiation of adjuvant therapy * participants enrolled in a clinical trial at any time during the study period * participants with a diagnosis and receiving treatment for another malignancy during the study observation period

Keywords: anti-programmed cell death protein 1 (pd-1) watchful waiting
dermacyte® liquid for treatment of cutaneous ulcers and wounds

Conditions: Cutaneous Ulcer; Diabetic Ulcer; Surgical Wound Dehiscence; Burns - Multiple; Pressure Ulcers; Mixed Ulcer; Ischemic Ulcer

Summary: the objective of this study is to make dermacyte liquid available on an expanded access basis to treat cutaneous ulcers and wounds refractory to initial treatment or that do not have adequate alternative treatments. minimal data will be collected to evaluate the efficacy and safety of dermacyte liquid.

the primary purpose is to provide expanded access of dermacyte liquid to subjects who have serious cutaneous ulcers and wounds (e.g., ulcers related to diabetes mellitus, venous insufficiency, complications of systemic sclerosis or rheumatic disease; decubitus ulcers, burns, acute trauma, wound dehiscence, ischemic ulcers, and mixed etiology ulcers). eligible subjects must have a high likelihood of significant morbidity, loss of quality of life, potential amputation, or mortality without efficacious treatment. as there are many types of patients who may be enrolled, study results will not have statistical significance.

Eligibility criteria:
inclusion criteria: * must be 18 years of age or older * must have a cutaneous ulcer or wound refractory to initial treatment or does not have an adequate treatment alternative, as determined by the investigator exclusion criteria: * must not be pregnant or lactating * must not have known malignancies * must not be less than 18 years of age
the effect of fish oil in major depressive disorder

Conditions: Major Depressive Disorder

Summary: the whole study was divided into two major parts: (a) the 12-week, double-blind, randomized controlled, parallel omega-3 fatty acid monotherapy study in 60 patients with mild to moderate major depressive disorder. (b) the double-blind, randomized controlled, parallel omega-3 fatty acid add-on prevention study in 60 patients with major depressive disorder in recovery status. the goals of this study were to examine the therapeutic and recurrence prevention effects of omega-3 fatty acids on major depressive disorder.


Eligibility criteria:
inclusion criteria: 1. dsm-iv criteria for major depressive disorder. 2. age being age 18-65. 3. capacity and willingness to give written informed consent. exclusion criteria: 1. any major medical illnesses. 2. a recent or past history of any axis-i diagnoses besides major depressive disorder, including psychotic disorders; cognitively impaired mental disorders; impulse control disorders; substance use disorder or substance abuse (last 6 months prior to the studies); primary anxiety disorders, including post-traumatic stress disorder and panic disorder; and bipolar disorders; or axis-ii diagnoses, i.e. borderline and antisocial personality disorder.
starting early to prevent obesity using telehealth (step out): intervention development trial

Conditions: Child Obesity; Breast Feeding; Feeding Behavior; Nutrition, Healthy

Summary: the goal of this intervention development study is to optimize the starting early to prevent obesity using telehealth (step out) intervention for feasibility and acceptability, using human-centered design and community-engaged research methods.

this intervention development study will enroll three to four consecutive cohorts to receive starting early to prevent obesity using telehealth (step out), an online, group-based nutrition education and parenting support program beginning in the third trimester of pregnancy and continuing through the first four to six months of infancy. it is tailored to hispanic/latinx families. step out will be delivered by a registered dietician/certified lactation counselor in coordination with the long island jewish medical center special supplemental nutrition program for women, infants, and children (lij wic). the step out curriculum is based on the starting early program (step), which uses didactic instruction, reflective discussion, interactive demonstrations, and hands-on practicing of skills to support prenatal nutrition and healthy early infant feeding practices. the details of program structure and content will evolve as the study progresses based on feedback from participants, interventionists, and our community advisory board. initially, we will plan to have 5 formal sessions structured as groups with multiple participants receiving the session simultaneously, primarily via remote videoconference, though sessions may occur individually, based on participant schedule and preference. each session will conclude with a structured feedback discussion designed to elicit targets and strategies for further program adaptation. we will collect feasibility and acceptability data after each session and at the end of the five-session program for each cohort. the iterative intervention adaptation process will be complete once all participants rate the intervention as "acceptable" or higher and fidelity is 90% or higher. we anticipate meeting this benchmark after 3 cohorts but may need to recruit an additional cohort to test subsequent adaptations, if necessary.

Eligibility criteria:
inclusion criteria: * pregnant with at least 14 weeks estimated gestational age * self-identify as hispanic/latinx * speak fluent english or spanish * at least 18 years of age * has a phone or device to participate in video calls * receiving or eligible to receive wic benefits exclusion criteria: * diminished mental capacity * serious medical or psychiatric illness * serious fetal illness
the imaging genetic study of the core family of obsessive-compulsive disorder (ocd) patient

Conditions: OCD

Summary: to investigate the structural/functional abnormalities and the possible genetic endophenotypes of obsessive-compulsive disorder (ocd) patients and their core families.


Eligibility criteria:
inclusion criteria: * diagnosed ocd patient exclusion criteria: * organic disease * other psychiatric disorder
clinical trial in males with bph (enlarged prostate)

Conditions: Urinary Retention; Prostatic Hyperplasia; Benign Prostatic Hypertrophy

Summary: a study to determine the effect on prevention of acute urinary retention (inability to urinate) in males with an enlarged prostate, also known as bph. * free study-related medical care provided.


Eligibility criteria:
* has been suffering for at least 6 months with any of the following symptoms: * daytime or nighttime urinary frequency * urgent feeling to urinate * difficulty starting urinary stream * interruption of urinary stream * feeling of incomplete urination * has not had a previous episode of acute urinary retention * has not been diagnosed with prostate cancer * has not had previous prostate surgery * is not an insulin-dependent diabetic

Keywords: acute urinary retention aur benign prostatic hyperplasia benign prostatic hypertrophy bph enlarged prostate
the outcome and influence factors of assisted reproductive therapy in patients with cesarean scar uterus.

Conditions: Infertile Patients With Previous Live Birth

Summary: mode of delivery affects the success rate of assisted reproductive techniques (art). in this case study, the investigators will evaluate changes in the bacterial ecology and inflammatory markers of the female uterus with different delivery modes. we will investigate whether the dominate endometrial microflora is interrupted by the cesarean section in the infertile women undergoing art, and the potential mechanism will also be further explored prospectively.

the highly prevalence of cesarean section rate in china had drawn great attention world widely. post-cesarean section scar diverticulum ( pcsd) is a poor healing of the local incision after cesarean section which happened in19.4%\~88% of patients. the cavity is formed by the original incision connected with the uterine cavity. patients with diverticulum are often accompanied by prolonged menstruation and uterine effusion, which may accompany with endometrial inflammation and impair embryo implantation rate. though cesarean section plays an important role in the treatment of dystocia and also decreasing perinatal mortality, it may impact natural conception and the success rate of art in secondary infertile patients. data from other researchers have revealed that cesarean scar may related to poor pregnancy outcome during art treatment. we have retrospectively analyzed the pregnancy outcome of art treatment in patients who have had live birth previously from january 2014 to may 2018. the biochemical pregnancy rate, embryo implantation rate and clinical pregnancy rate are all lower in patients with caesarean section compared to patients after natural labour, the clinical data is even worse in patients with pcsd. the results suggest a close correlation between the outcome of assisted reproductive therapy and the uterine condition. further evaluations are required related to whether the dominate endometrial microflora is interrupted by the cesarean section in the infertile women undergoing art, and the potential mechanism will also be explored accordingly. a single-center, prospective, case-control study will be carried out.

Eligibility criteria:
inclusion criteria: 1. women age ≥20 years and ≤40 years. 2. infertile women with previously live birth. 3. previous failed transfer cycle ≤2 4. didn't participate in other clinical subjects within three months. 5. written informed consent. exclusion criteria: 1. surgery history including: ovariectomy, myomectomy, adenomyomectomy. 2. uterine diseases including: uterine malformation, submucosal uterine fibroids and intrauterine adhesion. 3. one of couple has abnormal karyotype. 4. recurrent abortion ≥2. 5. untreated hydrosalpinx. 6. history of tuberculosis (pulmonary tuberculosis, pelvic tuberculosis etc.).

Keywords: secondary infertility, cesarean section, post-cesarean section scar diverticulum , endometrial microflora, inflammatory markers, clinical pregnancy, live birth
effect of disturbed attention on balance in children with spastic cerebral palsy

Conditions: Spastic Cerebral Palsy

Summary: the purpose of the current study is to determine if there is a correlation between disturbed attention and balance in children with spastic diplegia.

the neuromuscular impairments in children with cp are manifested in abnormal posture and loss of selective motor control, poor trunk control and balance which contributes to poor postural control with significant limitations in their activities of daily living. balance and upright postural control are fundamental components of movement which plays a major role in maintaining the body in equilibrium in a given sensory environment, with anticipatory and automatic postural adjustments. so, improving balance abilities in such children is fundamental. in general, attention involves processes that allow individuals to focus on particular aspects of the environment and to mobilize sufficient effort for learning and problem solving. children with diplegic cp encounter difficulties in sensory processing and integration which influence the achievement of mature postural control. there is reviews that didn't cover the relation between attention and balance. this study is to improve evidence regarding this area.

Eligibility criteria:
inclusion criteria: * cerebral palsy children with spastic diplegia. * age ranges from 8 -12 years. * level ι - ii according to gross motor functional classification system (gmfcs). * grade 1, 1+ of the modified ashworth scale. exclusion criteria: * children that suffer from epilepsy. * severe visual and auditory problems. * structural or fixed soft tissue deformities of lower extremities. * severe mental retardation. * botox injection in the lower extremity in the past 6 months.