Kornimate/medical-research-clean huggingface dataset:
a study of carboplatin/paclitaxel with pegfilgrastim supported by haematopoietic progenitor cell re-infusion in whole blood

Conditions: Breast Cancer; Lung Cancer; Ovarian Cancer

Summary: the purpose of this study is to provide dose-finding information regarding the efficacy and kinetics of peripheral blood progenitor cell (pbpc) mobilisation by pegfilgrastim and to determine if carboplatin/paclitaxel can be delivered at a reduced cycle interval when supported by pegfilgrastim-mobilised pbpcs in whole blood.


Eligibility criteria:
inclusion criteria: - pathologically confirmed diagnosis of malignancy (solid tumour) suitable for treatment with intensified carboplatin and paclitaxel - previously untreated with chemotherapy or radiotherapy - ecog performance status 0 to 2 inclusive - life expectancy greater than or equal to 12 weeks - anc greater than or equal to 2.0 x 10\^9/l, platelets greater than 100 x 10\^9/l - glomerular filtration rate greater than 60 ml/min exclusion criteria: - active infection requiring treatment with systemic (iv or oral) anti-infectives (antibiotic, antifungal, antiviral) within 72 hours of randomisation - known to be hiv positive - any premalignant myeloid condition or any malignancy with myeloid characteristics (e.g., myelodysplastic syndromes, acute or chronic myelogenous leukaemia) - prior malignancy within the last 5 years, with the exception of surgically cured basal/squamous skin cell carcinoma, and/or carcinoma of the cervix in-situ - history of impaired cardiac status \[e.g., severe heart disease (nyha greater than 2), cardiomyopathy, or congestive heart failure\] - bone marrow involvement of disease - major surgery within 2 weeks before randomisation - known sensitivity to e. coli derived drug products (e.g., filgrastim) - previous exposure to pegfilgrastim

Keywords: solid tumour unknown primary tumour carboplatin paclitaxel
nomogram for predicting difficult laparoscopic appendectomy

Conditions: Emergencies

Summary: no prior studies have stratified the difficulty of laparoscopic appendectomy (la). the investigators aimed to investigate preoperative factors as indicators of difficult las based on the experience of surgical trainees and to develop a predictive model accordingly.

acute appendicitis is the most common cause of surgical emergencies and laparoscopic appendectomy (la) is usually attempted by surgical trainees. this study aim to explore the preoperative and intraoperative factors affecting the degree of surgical difficulty and to establish a model for validation, so that it can be subsequently replicated in training programs.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute appendicitis * participants who underwent laparoscopic appendectomy exclusion criteria: * participants refused or could not tolerate laparoscopic appendectomy * incomplete preoperative examination or missed information

Keywords: laparoscopic appendectomy surgical difficulty training program
early detection of lung tumors by sniffer dogs - evaluation of sensitivity and specificity

Conditions: Lung Cancer; Chronic Obstructive Airway Disease

Summary: some groups reported that sniffer dogs can be applied to detect lung cancer in the exhaled breath of patients. therefore, breath samples (bs) of patients are collected. five sniffer dogs are trained to distinguish between the bs of patients with lung cancer and healthy individuals (controls). in a prospective, randomized blinded study the dog's ability to differentiate between bs of i) patients with lung cancer, ii) patients with inflammatory airway disease, but no evidence of cancer and iii) healthy individuals is tested.

all breath samples (bs) are collected in patients on the basis of radiologic findings before any intervention (bronchoscopy, biopsy or surgery) has been performed. the allocation to study groups is made following diagnostic work up and surgery. three study groups are defined using the following inclusion and exclusion criteria: * lung cancer: male \& female, age 18-80, competent, confirmed lung cancer in diagnostic work up and surgery, no history or present other tumor disease * healthy individual: male \& female, age 18-80, competent, no history or present other tumor disease including lung cancer, no pathological lung function tests * chronic obstructive lung disease: male \& female, age 18-80, competent, no history or present other tumor disease including lung cancer, pathological lung function tests for each patient, i) history, ii) present medication, iii) lung function tests are documented. for the lung cancer patients, the tumor stage following surgery is documented. five sniffer dogs are trained using bs of lung cancer patients and healthy individuals. after completion of the training the ability of the dogs to differentiate between the groups is tested: * 5 bs are presented in 1 experiment: * test i: lung cancer vs healthy individual * test ii: lung cancer vs chronic obstructive pulmonary disease * test iii: lung cancer vs healthy individuals \& bronchitis * for every experiment 1 bs of a lung cancer patient is used * the lung cancer sample is placed randomly in one of the five test tubes * the other test tubes are used for bs of healthy individuals or chronic obstructive pulmonary disease patients or both * neither the dog handler nor the dog know the loading of the test tubes * experiments are repeated 5 to 10 times for analysis, the sensitivity and specificity of the dog's reaction is determined. the patient's medication, smoking habits, age and gender are analysed to rule out confounders or bias.

Eligibility criteria:
inclusion criteria: * age 18-80 * competent * confirmed lung cancer exclusion criteria: * history of other cancers

Keywords: lung cancer exhalation analysis chronic obstructive pulmonary disease cancer screening test
a study to compare the efficacy of levocetirizine to placebo in reducing symptoms of seasonal allergic rhinitis (sar) in sensitive subjects exposed to ragweed pollen

Conditions: Rhinitis; Allergic; Seasonal

Summary: the purpose of the study is to assess the efficacy comparability of cetirizine and levocetirizine, by comparing the effects of single intake of the two drugs to placebo in reducing symptoms of seasonal allergic rhinitis (sar) in ragweed sensitive adult subjects exposed to ragweed pollen in an environmental exposure unit.


Eligibility criteria:
inclusion criteria: * female subject of non-childbearing potential or of childbearing potential agreeing not to become pregnant during the study. * have had seasonal allergic rhinitis due to ragweed for the last 2 consecutive years * subjects who obtain a minimum sum considering sar related symptoms (mean value) as defined by protocol exclusion criteria: * any clinically significant condition that might interfere with the treatment evaluation, both for efficacy and safety * have used forbidden concomitant medications as defined by the protocol

Keywords: levocetirizine xyzal rhinitis allergic seasonal ragweed
pain quantification and pain management in interventional radiology (ir)

Conditions: Pain

Summary: primary objectives: * to measure and record patients' pain levels before, during, and after standard procedures performed in ir. * to compare different procedures to respective pain levels and patient satisfaction (as determined by questionnaire).

during the ir procedure, nurses commonly ask patients to tell them what their pain level is on a 0-10 scale. for those who participate in the study, these numbers will be used to calculate average pain levels. study participants will be asked to complete the same 0-10 pain scale during the recovery period until time of discharge or admission to the hospital. according to standard criteria when giving conscious sedation, patients will remain in a communicable state throughout the procedure and during the recovery period prior to discharge, and thus, will be able to express a pain level during these times. the same questionnaire will be given for seven days after the procedure, which will be completed on a self-addressed, stamped postcard to be mailed back to utmdacc. the last postcard will have a couple of questions about patient satisfaction. once the last postcard is mailed in, the patient's participation in the study is over. each questionnaire should take less than 5 minutes to complete. this is an investigational study. about 374 patients will take part in this study. all will be enrolled at utmdacc.

Eligibility criteria:
inclusion criteria: * scheduled for an ir procedure at utmdacc * lives in the united states (easier to contact patients via phone/mailings) * english-speaking * provide written informed consent exclusion criteria: * refusal to participate * current diagnosis of mental illness, such as psychosis or dementia * procedure performed under monitored anesthesia care (mac), general endotracheal anesthesia (geta), or local anesthesia care

Keywords: interventional radiology pain quantification pain management patient satisfaction questionnaire survey
analysis of motor performance in children with duchene's muscular dystrophy

Conditions: Duchene&#39;s Muscular Dystrophy

Summary: 25 boys, ages ranging from 6 to 16 years, diagnosed with duchene's muscular dystrophy (dmd) will participated in the study. they will be selected from the pediatric rehabilitation center of deraya university's outpatient clinic in el-minia district, minia-egypt. the outcome will be assessed motor performance will be assed by bruininks-oseretsky test of motor proficiency second edition (bot™-2) : balance, running speed and agility, bilateral coordination and strength and by blue cherry; geratherm respiratory. it is used to measure vital capacity (vc), forced expired volume in one second (fev1), fev1/fvc, fev1/vc, and peak expiratory flow (pef) to provide objective information for monitoring lung health.


Eligibility criteria:
inclusion criteria: * the diagnosis is duchene's muscular dystrophy only not other types, * ambulated with or without assistance, * oriented and endurance enough to understand orders to perform ventilation on the blue cherry; geratherm respiratory device. exclusion criteria: * any cognitive or neurological condition (other than duchene's muscular dystrophy), * history of previous surgical operations that can affect pulmonary functions, and structural scoliosis

Keywords: duchene's muscular dystrophy pulmonary functions pediatrics motor performance
effect of inspiratory muscle training during pr on dyspnoea and exercise tolerance in copd patients

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease is a respiratory disease that results in progressive airflow limitation and respiratory distress. the benefit of inspiratory muscle training (imt) combined with a pulmonary rehabilitation programme is uncertain. the investigators aimed to demonstrate that, in patients with obstructive pulmonary disease, imt performed during a prp is associated with an improvement of dyspnoea and exercise tolerance.

the purpose of this study is to evaluate the effect of the inspiratory muscle training (with incremental load every two weeks in two months) performed during pulmonary rehabilitation on dyspnoea, 6 minutes walk test and quality of life using the st george's respiratory questionnaire (sgrq) in copd patients.

Eligibility criteria:
inclusion criteria: * were copd diagnosed by pulmonary function testing * clinically stable * abscence of other obstructive diseases * signed written consert exclusion criteria: * were previous pneumonectomy or lobectomy in the past 6 months * spontaneous risk of pneumothorax or rib fracture * incapacity to follow a standard rehabilitation programme (locomotor deficits, acute cardiac failure and acute exacerbation of copd at the beginning of the programme) * the absence of written informed consent.

Keywords: copd imt 6mwt dyspoea sgrq
feasibility and impact of a tele-rehabilitation program in patients with chronic and non-specific neck pain

Conditions: Chronic Non-specific Neck Pain

Summary: chronic neck pain has a high prevalence in developed countries, being one of the main causes of years lived with disability and deterioration of the quality of life. telerehabilitation is presented as a resource capable of favoring, with its development and implementation, the transition to a universal and quality health service. the main objective of the study is to assess the change in disability produced by a telerehabilitation program (applied in the intervention group) in patients with chronic and nonspecific neck pain compared to the recommendation of home exercises (control group). the study that will be carried out will be a controlled and randomized clinical trial (ecca), single-blind, longitudinal and prospective with two groups (intervention group and control group). the main study variables that are intended to be analyzed pre and post intervention are disability, quality of life, pain, adherence, and depression and anxiety. the study will take place between june 2020 and may 2021 in specialized physiotherapy clinics.


Eligibility criteria:
inclusion criteria: * people between 18 and 65 years of age * neck pain of more than 3 months of evolution * access and knowledge in the use of the internet * complete the informed consent exclusion criteria: * previous trauma to the cervical region (such as whiplash) * neck surgery * osteoporosis * arthritis * cervical radiculopathy associated with externalized cervical hernia * vertigo or vertebrobasilar insufficiency * cancer * vertebral fracture * fibromyalgia * cognitive impairment * psychiatric disorders.
out-of-hospital cpap for severe cardiogenic pulmonary edema

Conditions: Cardiogenic Pulmonary Edema

Summary: in cardiogenic pulmonary edema, continuous positive airway pressure (cpap) added to medical treatment improves outcome. the present study was designed to assess the benefit of cpap as a first line treatment of cardiogenic pulmonary edema in the out-of-hospital environment.

cardiogenic pulmonary edema (cpe) is a frequent presenting process for acute out-of-hospital practice. acute left heart failure may occur from a variety of processes that rapidly deteriorates to this generalized cardiopulmonary disorder. the classical treatment of out-of-hospital cpe includes supplemental oxygen, vasodilators, loop diuretics, and morphine. if not effective, or because of the associated respiratory depression, tracheal intubation and mechanical ventilation are often needed, which, by themselves are associated with a worse prognosis. continuous positive airway pressure (cpap) has been proposed as an alternative to mechanical ventilation in cpe. this technique not only improves alveolar recruitment and decreases the work of breathing 4 but also reduces left ventricular afterload, and both right and left ventricular preload. the overall effect of cpap in the acute management of cpe is to improve cardio-respiratory function and sustained tissue oxygenation. furthermore, the combination of cpap with medical treatment in patients with cpe significantly reduces the need for intubation and improves the outcome. unfortunately, very limited data are available on the effects of cpap in the out-of-hospital practice. thus, we tested the potential benefit of immediate use of cpap alone in comparison with pharmacological therapy in treatment of cpe in the acute out-of-hospital environment. the protocol lasts 45 minutes, divided into 3 periods of 15 minutes. patients with severe pulmonary edema are randomly assigned in 2 groups: 1/ "early cpap" (n=63): cpap alone (t0-t15); cpap + medical treatment (t15-t30); medical treatment alone (t30-t45); 2/ "late cpap" (n=61): medical treatment alone (t0-t15); medical treatment + cpap (t15-t30); medical treatment alone (t30-t45). primary endpoint : effect of early cpap on a dyspnea clinical score and on arterial blood gases. secondary endpoints : incidence of tracheal intubation, inotropic support, and in-hospital mortality.

Eligibility criteria:
inclusion criteria: * patients with clinical symptoms of acute pulmonary edema such as orthopnea, diffuse crackles without evidence of pulmonary aspiration or infection, percutaneous oxygen saturation  90% despite supplemental oxygen therapy (15 l.min-1) provided by the first responders were included in the study. exclusion criteria: * patients with a history of chronic obstructive pulmonary disease, asthma, severe stenotic valvular disease, or if they had cardiovascular collapse or an impaired level of consciousness.

Keywords: cardiogenic pulmonary edema non invasive ventilation cpap
international low anterior resection score evaluation

Conditions: Low Anterior Resection Syndrome

Summary: * aim: the aim of this study is to perform a prospective, international 4 months cohort study evaluating bowel function before curative rectal cancer surgery and one year after the surgery using the lars score. * primary outcome measure: lars score before surgery and 1 year after the surgery. * primary comparison: between average lars score before and after curative surgery and also comparing these with publish lars score on normal population.

all patients undergoing treatment for rectal rectal will be included in the study. before any treatment all the included patients will be asked to fill the lars score (5 question questionnaire with differently weighted answers for assessing the low anterior resection score). one year after the low anterior resection (without the stoma) or following the stoma take down patients will be reassessed. the lars score will be filled one again. patient characteristics, age, cancer stage, level of anastomosis will be assessed aswel.

Eligibility criteria:
inclusion criteria: * patients undergoing rectal cancer surgery on curative intent. * elective surgery patients. * laparoscopic, laparoscopic-converted, robotic, tatme (transanal total mesorectal excision) and open cases will be included. * patients aged 18 years and over should be included. exclusion criteria: * patients undergoing a procedure purely for diagnosis or staging should be excluded. * patients with palliative treatment. * patients with recurrence should be excluded. * patients with dementia * patients who do not complete their treatment within 12 months of primary surgery e.g. including reversal of stoma, chemotherapy etc

Keywords: rectal cancer low anterior resection low anterior resection syndrome
respiratory physiotherapy after cardiac surgery

Conditions: Functional Disturbance Following Cardiac Surgery

Summary: although incentive spirometry is commonly used to avoid pulmonary complications in cardiac surgery patients, the breath-stacking technique has been proposed as an alternative to increase pulmonary volumes in the post-operative period. objective: to compare inspiratory volume and electromyographic activity of respiratory muscles during breath stacking technique and incentive spirometry in patients undergoing cardiac surgery.

the purpose of the present study are: 1. to evaluate and compare the inspiratory volume during the course of breath stacking and incentive spirometry techniques in patients submitted to myocardial revascularization surgery. 2. to compare the electromyographic activity of the scalene, sternocleidomastoid (scm) and diaphragm muscles during both techniques.

Eligibility criteria:
inclusion criteria: * patients submitted to myocardial revascularization surgery exclusion criteria: * cognitive impairment or incoordination to perform is * face mask intolerance during bs * level of consciousness incompatible to perform is * hemodynamic complications \[arrhythmia, intraoperative myocardial infarction, major blood loss (defined as a loss of ≥20% of total blood volume), mean arterial pressure \<70 mmhg and reduce cardiac output requiring the use of an intra-aortic balloon pump or vasoactive drugs) * intubation for more than 72 h after admission to the intensive care unit * the need for reintubation.

Keywords: physiotherapy cardiac surgery breath stacking
plr in a good helath after 24 week of preganancy

Conditions: ITV Sosu Aortique; Cardiac Output, High; PLR

Summary: fluid resuscitation is one of the bases of strategies in icu to take in charge patients , one of the technique to evaluate preload charge , is passive leg raising, that allows reliable prediction of fluid responsiveness even in patients with spontaneous breathing activity or arrhythmias . in recent years, hemodynamic response to passive leg raising (plr) has been popularized as a dynamic test of preload responsiveness \[1\]. this manoeuvre provides an "auto-fluid challenge" which is rapid, transient and reversible. plr transfers blood contained in the venous reservoir of the lower extremities to the central venous compartment leading to a transient increase in preload and an increase in cardiac output by frank-starling mechanism in preload responsive individuals. untille now the usseuful of plr in pregnancy, and also the validity of dynamic measurements of preload to predict fluid response during pregnancy are note clear in littérature .

a total of 108 low-risk pregnant women and 54 healthy non-pregnant controls, aged \>18 years, participated in the study. pregnant women attending for the second trimester routine ultrasound screening at 17-19 weeks of gestation were informed about the study and invited to participate if they had a low-risk pregnancy and ultrasound scan did not show any fetal or placental abnormality. those who agreed were consecutively enrolled and an appointment was made for functional hemodynamic evaluation at 22-24 weeks of gestation. exclusion criteria were any pre-existing medical condition that may have an effect on the course of pregnancy, and a previous history of preeclampsia, gestational diabetes, intrauterine fetal growth restriction or preterm delivery. non-pregnant controls were recruited among the nursing, administrative and laboratory staff of the hospital and university. healthy women of reproductive age were asked to attend for hemodynamic assessment during the follicular phase between day 5 and 10 of the menstrual cycle. women with a previous history of pregnancy complication and those with a known disease or on regular medication were excluded. examination was performed,

Eligibility criteria:
inclusion criteria: * all pregnante women in good health after 24 week of preganancy exclusion criteria: * all young women under 18 years old * unhealthy women

Keywords: co plr ett pregnanacy