Kornimate/medical-research-clean huggingface dataset:
effects of a peer-led educational intervention based on theory of planned behavior on substance use intentions and behaviors among secondary school students of dessie and kombolcha town, northeast ethiopia.

Conditions: Substance Use

Summary: this study aims to measure the effects of a per-led educational intervention based on theory of planned behavior to reduce tobacco, alcohol and khat use and intention to use among secondary school students over 3-months of follow-up in dessie and kombolcha town, northeast ethiopia.

this study aims to measure the effects of a per-led educational intervention based on theory of planned behavior to reduce tobacco, alcohol and khat use and intention to use among secondary school students over 3-months of follow-up in dessie and kombolcha town, northeast ethiopia.a quasi-experimental nonequivalent control group pretest-post-test design will be carried out among secondary school students of dessie and kombolcha town from april to august, 2021. individuals/students/ in those selected schools will be allocated as intervention and control group purposively. the study will include 748 students from two secondary schools for the intervention group and another 748 students for the control group from other two secondary schools. the per-educational intervention will be planned based on results of the elicitation and tpb constructs and will be implemented on the experimental group for three months. both experimental and control groups will be followed up after three months of educational intervention using the same tools and methods on same participants interviewed in pretest survey. primary outcomes are substance(cigarette,alcohol and khat) use intention and behavior. secondary outcome are attitudes, subjective norms, and perceived behavioral control over substance(cigarette,alcohol and khat) use. self-administered questionnaire based on tpb constructs will be used to collect the baseline and follow up data. in-depth interviews will be employed to explore the salient beliefs about substance use. the data will be analyzed using spss statistical software package version 20 using appropriate statistical tests including paired t-test, independent t-tests, mcnemar and multivariate logistic regression analysis. all statistical tests will be carried out using two tailed tests with alpha set at 0.05. information from the interviews will be transcribed verbatim, analyzed, and coded thematically.

Eligibility criteria:
inclusion criteria: * all grade 9-12 students, both girls and boys with any substance use experience (non-user, current user, and ever users) (aged 15-24 years) attending the four secondary schools of dessie and kombolcha town are eligible. exclusion criteria: * grade 9-12 students who are not wanting to attend the evaluation and not able to have a follow- up will be excluded from the study.

Keywords: substance use, alcohol ,cigarette and khat
pulmonary disease requiring ambulatory oxygen therapy -resilience and quality of life

Conditions: Pulmonary Disease

Summary: dyspnea is common symptom in pulmonary diseases, like chronic obstructive pulmonary disease (copd) or other pulmonary disease. ambulatory oxygen therapy is often prescribed to these patients. in these patients resilience, health related quality of life, life satisfaction are measured and the effect and patient satisfaction to ambulatory oxygen therapy are studied.

dyspnea is a common symptom in pulmonary disease patients, such as chronic obstructive pulmonary disease (copd) and interstitial lung diseases. these patients often have low health-related quality of life (hrqol) and life satisfaction (ls), and high levels of anxiety and depression. oxygen therapy is used in severe pulmonary diseases to improve hrqol and prolong survival. ambulatory oxygen therapy is prescribed to patients who become transiently hypoxemic, e.g. during exercise or normal outdoors activities. however, only 46 % of copd patients were adherent to long-term oxygen therapy. proper adaptation to a serious illness, such as advanced copd and interstitial lung diseases, necessitates resilience. resilience is an ability to adapt appropriately in difficulties in life. this ability is based on a person's psychological resources, and it can be learned and improved with time and effort. evaluation of resilience is commonly applied in psychological examinations and research, but less attention has been paid in medical context even though resilience capacity is closely connected to recovery abilities and adaptation. the main aim is to measure resilience in pulmonary disease patients receiving ambulatory oxygen therapy and how it correlates with other measures of hrqol and ls. also anxiety and depression are surveyed and satisfaction to ambulatory oxygen therapy devices and associated services.investigators also compare the hrqol of pulmonary disease patients receiving ambulatory oxygen therapy to an age and gender matched sample of the general population. primary outcome measure was the proportion of patients with low resilience, and secondary outcomes were how resilience correlated with hrqol, ls, anxiety and depression in patients prescribed ambulatory oxygen therapy.

Eligibility criteria:
inclusion criteria: * patient with pulmonary disease (e.g. copd) who has ambulatory oxygen * patient with pulmonary disease (e.g. copd) who is starting to use ambulatory oxygen * adult patient * informed consent of the patient received exclusion criteria: * ambulatory oxygen prescribe for treatment of other than pulmonary disease. * age less than 18 years * dementia or other cognitive impairment that disables understanding of the study * no informed consent

Keywords: resilience psychological quality of life oxygen inhalation therapy lung diseases
preventive treatment of episodic and chronic migraine

Conditions: Migraine With Aura; Migraine Without Aura; Chronic Migraine

Summary: this is an open label pilot study to determine whether milnacipran can reduce headache frequency in episodic and chronic migraine sufferers.

patients with episodic migraine with and/or without aura and chronic migraine will be treated with 100 or 200 mg of milnacipran for a total of 4 months including a one month titration phase and a 3 month maintenance phase. baseline (pre-treatment) and end-of-maintenance phase headache frequencies will be recorded. there is no placebo treatment in this study. in addition to headache frequencies, other parameters being measured include safety and tolerability.

Eligibility criteria:
inclusion criteria: * migraine with or without aura or chronic migraine. * subject age 18 to 70. * at least 2 migraine attacks per month. * willing ang able to give written informed consent. * willing and able to complete the entire course of the study and to comply with study instructions. * willing to taper and discontinue their current preventive medications. exclusion criteria: * subject is pregnant, lactating or planning a pregnancy in the next year. * subject is female of child-bearing potential and not taking adequate forms of birth control. * significant medical or psychiatric disease or abnormal laboratory data that would preclude entry into this study. * previous failure of four or more adequate trials of preventive medication. * currently on any form of antidepressant for depression and not able to discontinue. * currently demonstrating medication overuse headache. * currently has uncontrolled narrow angle glaucoma. * currently taking monoamine oxidase inhibitors. * subject has a history of seizures. * participation in an investigational drug study within the last 30 days or 5 half-lives, whichever is longer.
study evaluating single doses of sbi-087 in subjects with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to determine the safety and tolerability of single doses of sbi-087 in subjects with rheumatoid arthritis.


Eligibility criteria:
inclusion criteria: * man or nonlactating and nonpregnant woman, aged 18 to 70 years, inclusive, at the screening visit. * must meet criteria for rheumatoid arthritis with functional class i to iii. * diagnosis of rheumatoid arthritis more than 6 months before study day 1 and rheumatoid arthritis onset after 16 years of age exclusion criteria: * any significant health problems other than rheumatoid arthritis. * treatment of greater than 10 mg of prednisone per day. * treatment with cyclophosphamide.

Keywords: ascending single dose safety pharmacokinetics open-label
laparoscopic versus open surgical management of post cholecystectomy bile duct injury

Conditions: Bile Duct Injury

Summary: comparison between laparoscopic and open surgical management of post cholecystectomy bile duct injury.

bile duct injury (bdi) post cholecystectomy is an iatrogenic catastrophe associated with significant morbidity , mortality and poor quality of life this is due to the large number of cholecystectomies per year all over the world. cholecystectomy whether open or laparoscopic is done in large number about 750,000 annually in usa, the incidence of bdi post cholecystectomy is about 0.1-0.2% in open cholecystectomy and 0.4-0.6% in laparoscopic cholecystectomy although the percentage appears small but it still large number about 2100 patients per year. the two most frequent scenarios of bdi may be occurrence of bile leak or bile duct obstruction. early recognition of iatrogenic bile duct injury is essential to prevent major morbidity by imaging techniques, such as ultrasound and ct which are extremely valuable during the initial evaluation but mrcp remains the gold standard for diagnosis. ercp can confirm the presence of biliary injury and provides a means for definitive management. the main aim of surgical treatment is the reconstruction of proper flow of bile to the alimentary tract. repair of such injuries still remains a challenge due to the variety of size of injury, site of injury if proximal or distal, the severity of injury and the time of presentation after the injury. repair of such bdi may be done by laparoscopy or by open surgery which still a matter of debate. there are many described techniques should be done by specialized hepatobiliary surgeon from simple repair, repair over t-tube up to hepaticojejunostomy. despite widespread advances in laparoscopic surgery, laparoscopic repair of post-cholecystectomy bile duct injury (bdi) has rarely been reported related mainly to technical difficulty.

Eligibility criteria:
inclusion criteria: 1. all patients with post cholecystectomy bile duct injuries admitted to surgery department in asyut university hospitals and el-rajhi hospital at the period of the study. 2. patients fit for surgery. 3. patients informed consent for study. 4. patients with signs and symptoms due to bile duct injury like abdominal pain, jaundice and high liver function parameters exclusion criteria: 1. unfit cases for laparoscopic surgery. 2. unfit patients for open surgery. 3. patients refuse consent to participate in the study. 4. patients who had previous repair. 5. patients who present with abdominal sepsis.
serum micrornas as diagnostic biomarkers of colorectal cancer

Conditions: MicroRNAs; Colorectal Cancer; miR-15b; miR-21

Summary: evaluation the diagnostic value of certain micrornas as biomarkers of colorectal cancer by comparing its expression levels in colorectal cancer patients and normal individuals.

colorectal cancer (crc) is the second commonest cause of cancer deaths and the third most common cancer worldwide. five year survival of patients with stage 1 crc is 92%, and decreases to 10% at stage 4 crc. so, crc diagnosing at an early stage is the most important factor influencing disease prognosis. most crc patients are diagnosed after being symptomatic, but studies show that once the symptoms are present it mostly signifies late-stage disease. colonoscopic screening of asymptomatic patients has been shown to pick up early-stage crc. however, this is limited by cost issues and patient attitudes. therefore, more efforts could be done to view to early diagnosis of crc in asymptomatic patient. biomarkers are molecules that can serve as signals of disease activity and pathological processes. crc biomarkers can help in early diagnosis. micrornas (mirnas) are non-coding molecules that impact the expression of target genes in cell. also, they exist in highly stable, cell free form in peripheral blood. they are detected by quantitative real time polymerase chain reaction (qrt-pcr). data also shows that certain mirnas are elevated in the plasma and tissues of crc patients and decrease in plasma levels after operative treatment. there are over 2000 different mirnas and they are estimated to regulate 30% of the human genome. mirna dysregulation is also associated with multiple cancers. mirnas seem to show significant promise with high sensitivity and specificity for crc, but with limiting factors of limited data for high risk polyps and significant heterogeneity in test media and non-standardisation of test panels. further research would be required to bridge these knowledge gaps. interestingly, mir-15b and mir-21 appears to be the best diagnostic accuracy values for crc.

Eligibility criteria:
inclusion criteria: * adults (age 18-75) diagnosed with primary crc (histopathologically confirmed). * crc patients who have not received prior treatment (i.e., chemotherapy or radiation). * age-matched healthy controls without colorectal disease exclusion criteria: * patients with secondary tumors or metastasis originating from non-colorectal sources. * patients with prior history of crc. * patients who refuse to contribute in this study.
study of adults and adolescents with vasomotor rhinitis

Conditions: Rhinitis, Vasomotor

Summary: the primary objective of this study is to compare the efficacy and safety of gw685698x 100mcg once daily (qd) aqueous nasal spray with vehicle placebo nasal spray in adult and adolescent subjects (12 years of age and older) with vasomotor rhinitis (vmr).


Eligibility criteria:
inclusion criteria: * must be outpatients. * diagnosis of vmr. * literate in english or native language. exclusion criteria: * significant concomitant medical condition. * use corticosteroids or other allergy medications during the study. * used tobacco products within the past year.

Keywords: vasomotor rhinitis vmr nonallergic rhinitis gw685698x
phase ii study of neoadjuvant chemotherapy with doxorubicin followed by docetaxel-cisplatin in locally advanced breast cancer

Conditions: Breast Cancer

Summary: phase ii study of neoadjuvant chemotherapy with doxorubicin followed by docetaxel-cisplatin in locally advanced breast cancer


Eligibility criteria:
inclusion criteria: * patients with locally advanced breast cancer exclusion criteria: * patients with metastatic breast cancer
suction based characterization of healthy and diseased skin

Conditions: Systemic Sclerosis

Summary: the mechanical properties of healthy and ssc-diseased skin will be assessed by suction based measurements. the negative pressure needed to gain a certain tissue elevation, tissue elevation in response to a certain negative pressure as well as the time of retraction of tissue will be recorded and analyzed. mesurments will be done with the new developed aspiration device_nimble and with the ce-certified cutometer mpa 580.

patients with systemic sclerosis (ssc) show a thickening of the skin due to massive deposition of collagen and temporary edema in the dermis. the clinical palpation method is currently the only diagnosis method. for an objective detection a non-invasive skin elasticity measurement can be performed. the widely used approach is based on local tissue suction. this study aims at an identification and quantification of mechanical and structural properties of human skin. the results will then be compared in age- and gender matched control groups. for evaluation of the skin elasticity measurement the results will be compared to the clinical parametar validated, modified rodnan skin score (mrss). the mechanical properties of healthy and diseased skin will be assessed by suction based measurements. the negative pressure is needed to gain a certain tissue elevation. tissue elevation in response to a certain negative pressure as well as the time of retraction of tissue will be recorded and analyzed. (the different parameters depend on

Eligibility criteria:
inclusion criteria: -signed informed consent healthy volunteers: - age ≥18 years old ssc-patients: * age ≥18 years old * diagnosis of systemic sclerosis according to the acr/eular 2013 criteria * skin thickening diagnosed by clinical expert exclusion criteria: * known or suspected non-compliance, drug or alcohol abuse, * inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant, * previous enrolment into the current study, * participants, who are unable to hold still * impaired skin at the regions of measurements
brain connectivity and mindfulness training in youth with bipolar disorder not otherwise specified (nos)

Conditions: Bipolar Disorder, NOS

Summary: the investigators propose to study 30 adolescents with bipolar disorder, not otherwise specified (bd nos) and a family history of bipolar i disorder (bd) at baseline with rs-fmri (functional magnetic resonance imaging) and functional connectivity (fc) analyses and compare data with previously acquired rs-fmri and fc data from 20 age- and gender-matched healthy controls (hc). subjects will then undergo a 12-week mindfulness based stress reduction- teen (mbsr-t) intervention and be reassessed and rescanned. the intervention and scanning will take place in groups of 6-8 subjects/group/year over the 4 years. this proposal will be a natural progression of past research, while extending the investigators' expertise to include advanced fc analyses and mindfulness based interventions in youth with mood dysregulation. the investigators will also integrate trainees into the imaging and therapy components of this study, furthering our mission of mentoring the next generation of innovative researchers who will push the field forward.


Eligibility criteria:
inclusion criteria: * ages 13-17 * diagnosed with bd-nos * first or second degree relative diagnosed with bipolar i or ii exclusion criteria: * not english speaking * for those who are to participate in the mri scan, having any metal in the body or movement disorders will be an exclusionary factor
glidesheath slender® versus conventional 6 french arterial sheath: impact on the distal radial artery occlusion (smart)

Conditions: Coronary Artery Disease; Cardiovascular Diseases

Summary: compared with conventional artery sheath (terumo, introducer ii ), glidesheath slender® has more smaller outer-side diameter. the investigators suspected that use of the glidesheath slender® can reduce the incidence of distal radial artery occlusion in cardiovascular intervention via dtra approach.

distal transradial artery (dtra) approach has emerged as a new approach in cardiovascular intervention in recent years. compared to the conventional radial artery (cra) approach, the dtra approach dramatically reduced the risk of radial artery occlusion (rao). in recent years, the incidence of distal radial artery occlusion (drao) after dtra intervention has been reported in the literature, ranged from 0.12% to 5.2%. outside diameter of artery sheath may affect the incidence of drao. retrospective study reported that an artery/ sheath ratio \> 1.0 was least damaging to the vessel during coronary intervention via dtra. compared with conventional artery sheath (terumo, introducer ii ), 6 french glidesheath slender® has more smaller outer-side diameter (2.46mm vs. 2.62mm). the investigators suspected that use of the glidesheath slender can reduce the incidence of drao in cardiovascular intervention via dtra approach.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * palpable distal radial and conventional radial artery exclusion criteria: * age ≥ 90years * height≥ 185cm * st-segment elevation myocardial infarction or cardiogenic shock * contraindications to puncture at the puncture site * diameter of dra less than 1.5mm or rao

Keywords: distal radial artery distal radial artery occlusion cardiovascular intervention
the feasibility and efficacy of a telerehabilitation program for people with knee osteoarthiritis in sri lanka

Conditions: Knee Osteoarthritis

Summary: it will be 8 week zoom program of exercises for knee osteo arthritis. participant will be selected according to elegibilty criteria. pre and post measurements will be obtained. then feasibility and efficacy will be assesed.

this research is to check the feasibility and efficacy of a telerehabilitation program for people with knee osteoarthritis in sri lanka. 14 people with knee oa will be recruited according to the inclusion and exclusion criteria. study group will be selected with advertisement on facebook. people who are interested will be included. exercise booklet and instruction materials will be given to patients and initial measurement of pain using vas scale, 30 cst (30 second chair stand test)- lower extremity muscle strength and dynamic balance, womac (western ontario and mcmaster universities arthritis index)- pain, stiffness and physical activity will be obtained. study group will go for 8 weeks of zoom program of exercises. classes will be taken by the physiotherapist 3 days per week with standardized program called peak.knee log book will be maintained by therapist. post 8 week same measurements on baseline will be reassessed and additional to that, feasibility and acceptability for tele rehabilitation and patient adherence and safety will be assessed with attrition rate, satisfaction rate , participation to the program and measuring adverse effect respectively. statistical package for social science (spss) version for windows will be used for data analysis. pair t test will be used to compare the baseline and post 8 week results.

Eligibility criteria:
inclusion criteria: meet national institute for health and care excellence clinical criteria for oa * age ≥45 years. * activity-related knee joint pain. * morning knee stiffness ≤ 30 min. * report history of knee pain ≥ 3mths. * report knee pain on most days of the past month. * report an average pain score of at least 4 on an 11-point numeric rating scale during walking over the previous week. * report difficulty walking and climbing stairs. * have access to a device with internet connection: if they can use without assistance if possible exclusion criteria: * on waiting list for/planning knee/hip surgery in next 12 months. * previous arthroplasty on affected knee. * recent knee surgery (past 6 months). * consulting/ed physiotherapy or doing strengthening exercise for knee (past 6 months). * self-reported inflammatory arthritis (eg rheumatoid arthritis). * any neurological condition affecting lower limbs; and/or any unstable/uncontrolled cardiovascular condition. * clearance to participate from a general practitioner will be required for anyone who reported a fall (past 12 months) or is house-bound due to immobility

Keywords: telerehabilitation feasibility efficacy sri lanka