Kornimate/medical-research-clean huggingface dataset:
hyperglycaemia and hyperlactataemia in patients with severe acute brain injury

Conditions: Acute Brain Injury; Hyperglycemia; Hyperlactatemia

Summary: this is an observational study of patients with severe acute brain injury, which aims to characterize the development of hyperglycaemia and hyperlactataemia and the influence of these markers on clinical outcome. additionally, in a subgroup of patients undergoing advanced multimodal neuromonitoring on either clinical or research indication, the relationship between hyperglycaemia and brain glucose levels as well as systemic and microdialysis lactate will be examined.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * admission to the neurointensive care unit at rigshospitalet * diagnosis of acute brain injury categorised as tbi, sah, ich, ischaemic stroke, or other conditions exclusion criteria: * brain death before inclusion * closest relatives do not understand written and spoken danish or english
copd, inflammation and rehabilitation

Conditions: COPD

Summary: patients with chronic obstructive pulmonary disease, also known as copd or emphysema, is like any other with a chronic illness not only affected by the physical discomfort the illness gives. for copd patients that is: accelerated loss of lung function, conditioning and increased mortality: 25% of patients hospitalized with copd exacerbation die 12 months later. patients are also characterized by various psychological factors such as reduced quality of life, depression, etc. therefore, everywhere in the country newly diagnosed copd patients are offered rehabilitation in region zealand which consists of 10 weeks of classes 2 hours, 2 times a week with physical exercise, smoking cessation, medication, nutrition education and psychosocial support and patient education based on the national health service and international recommendations. in the literature, the effect of rehabilitation on quality of life was measured using a questionnaire (st. george respiratory questionnaire (sgrq)), and the increase in function has been measured using a walk test, but there are no studies which look at the effect on inflammation lungs. it is important for copd patients is to prevent exacerbations of the disease, which sometimes requires hospitalization and sometimes treated by their own doctor. it has been proven that inflammation in the lungs is associated with disease severity and exacerbation frequency, and therefore we would like to investigate whether both rehabilitation, close monitoring of patients with time in the pulmonary clinic every 3 months, and instruction in self-administration of medication (antibiotics and corticosteroids) have an effect on especially inflammation in the lungs, number of exacerbations, mortality, lung function and walking capacity.


Eligibility criteria:
inclusion criteria: * the study includes consecutive patients over 18 years admitted to the medical dept, næstved hospital with aecopd (2 of 3 symptoms: increased breathlessness, sputum or purulens thereof) on the basis of known copd (post-bronchodilator fev1 \<80% and fev1/fvc \<70% ; measured in stable phase, ie. earlier than 4 weeks after aecopd). patients included during hospitalization for aecopd exclusion criteria: * patients can not participate if they have asthma (post-bronchodilator fev1 increased by\> 15%), are pregnant, nursing, has known serious comorbidities (eg cancer, chronic liver cirrhosis or hepatitis) or cannot give informed consent
nirs measurement after scp block

Conditions: Arterio-venous Fistula

Summary: peripheral regional anesthesia induces a sympathectomy-like effect with neurovascular changes causing increased arterial blood flow and venodilatation . near-infrared spectroscopy (nirs) can be applied to different kinds of tissue providing oxygen saturation by detecting the absorption and reflection of near-infrared light . the effect on peripheral tissue oxygenation in patients undergoing arteriovenous fistula revision has not yet been examined. we postulate an increase in tissue oxygenation by sympathicolysis caused by peripheral regional anesthesia that might be the reason for beneficial outcome. the aim of our study was to demonstrate the effect of a supraclavicular plexus block in this group of patients.


Eligibility criteria:
inclusion criteria: * all patients undergoing surgery under regional anaesthesia exclusion criteria: * patients refusal

Keywords: nir spectroscopy nerve blockade surgical arteriovenous shunt
task oriented training in post stroke patients

Conditions: Stroke

Summary: this study will be observe the effect of task-oriented training on the dexterous movements of hands in hemiparetic post-stroke patients. patient will be recruited that meet the inclusion criteria, with unilateral hemiplegia referred by neurophysician having stroke for the first time, between age 47-70 year, both males and females, score of spasticity for upper extremity (shoulder, elbow) below and equal 2 based on the modified ashworth scale (mas), ability to comprehend simple instructions (mini-mental state examination with a minimum score \> 24), brunnstrom stages ≥ 4, not submitted to other upper-limb rehabilitation programs during the participation in this study. the individuals with recurrent stroke episodes and transient ischemic attack, other neurological diseases (parkinson's disease, multiple sclerosis,), hemineglect, no sitting balance and comorbidities are excluded. outcome measures used are fuglmeyer assessment scale (wrist and hand) and wolf motor function test for upper extremity while barthel index to assess the activities of daily living. all procedures will perform by taking informed consent. all ethical standards for both patient and institution will be followed. after collecting data, will apply shapiro wilk test to check the normal distribution of data. for analysis use spss version 25


Eligibility criteria:
inclusion criteria: unilateral hemiplegic stroke patients referred by neuro-physician (both ischemic and hemiplegic stroke patients). * patient with first time stroke (within 6month of onset). * age between 45-70 years of age. * gender both male \& females. * ability to comprehend simple instructions (mini-mental state examination with a score of \>24 ). * score of spasticity for upper extremity (shoulder, elbow) below and equal 2 based on the modified ashworth scale (mas). * motor recovery of upper limb brunnstrom stages ≥ 4. * not participated to other upper-limb rehabilitation programs during the participation in this study. exclusion criteria: recurrent stroke attacks, transient ischemic attacks(tia). * previous injury, disease, or contracture of the upper extremity and no sitting balance. * any comorbid neurological disease or condition such as multiple sclerosis, parkinson disease, spinal cord injury, traumatic brain lesions, brain tumor, epilepsy, or dementia, * had hemineglect phenomena.

Keywords: stroke task training movement
the affection of two chest management for enhanced recovery program after video-assisted thoracoscopic lobectomy.

Conditions: Chest Tube

Summary: comparing the influences of different chest tube managements for enhanced recovery program after video-assisted thoracoscopic lobectomy.

the enhanced recovery program has a series of observation data contains hospitalization days, adverse events, drainage, extubation, visual analogue scale(vas) scores and the number of analgesic using.the investigators plan to enroll 60 patients and divide them into two groups to compare the influences of different chest tube managements for enhanced recovery program after video-assisted thoracoscopic lobectomy.

Eligibility criteria:
inclusion criteria: * only single lesion on the targeted lobe * considered as invasive carcinoma by preoperative computed tomography (ct) or -diagnosed by intraoperative pathology * patients have signed informed consent. exclusion criteria: * patients have critical basic disease(diabetes and hypertension). * patients who lung function cannot undertake the lobectomy. * the lesion has the possibility of metastasis. * finding serious adhesion to pleura during operation

Keywords: eras(enhanced recovery after surgery) video-assisted thoracoscope lobectomy non-small cell lung cancer (nsclc) chest tube
compaction femur preparation for cementless total hip arthroplasty (tha) unilateral

Conditions: Coxarthrosis

Summary: this is a prospective, randomized study comparing two different bone preparation techniques for insertion of a hydroxylapatite (ha) coated titanium cementless femoral stem. patients who receive a unilateral total hip replacement are randomized to either conventional broaching or compaction. hypothesis: compaction results in significantly less stem migration \[evaluated by radiostereometric analysis (rsa)\], less peri-prosthetic bone mineral density (bmd) loss \[evaluated by dual energy x-ray absorptiometry (dexa)\], and a higher harris hip score after two years.


Eligibility criteria:
inclusion criteria: * patients with primary arthritis in the hip * patients with sufficient bone density to allow uncemented implantation of a femoral component * informed patient consent in writing exclusion criteria: * patients with neuromuscular or vascular disease in the affected leg * patients found upon operation to be unsuited for uncemented acetabulum component * patients who regularly take non-steroidal anti-inflammatory drugs (nsaids) and cannot interrupt intake for the postoperative phase of the study * patients with fracture sequelae * female patients of childbearing capacity * hip joint dysplasia * sequelae to previous hip joint disorder in childhood

Keywords: tha
liposomal doxorubicin in treating patients with liver or bile duct cancer

Conditions: Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Liver Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. purpose: phase ii trial to study the effectiveness of liposomal doxorubicin in treating patients with liver or bile duct cancer.

objectives: i. determine the response rate and toxicity of doxorubicin hcl liposome in patients with carcinomas of the liver and bile ducts. outline: patients receive doxorubicin hcl liposome iv over 15 minutes every 21 days. filgrastim (g-csf) is administered subcutaneously starting on day 2 and continuing for 10-14 days. disease is restaged after every 3 courses. treatment continues in the absence of unacceptable toxicity or disease progression. patients are followed every 3 months for the first year, and then every 6 months thereafter. projected accrual: there will be 17-26 evaluable patients accrued into this study.

Eligibility criteria:
disease characteristics: histologically confirmed carcinoma of the liver or bile ducts including hepatocellular carcinoma, cholangiocarcinoma, and gallbladder cancer measurable or evaluable disease by ct scan (ascites, pleural effusions, and bone metastases are not considered evaluable) patient characteristics: age: 18 and over performance status: ecog 0-2 life expectancy: not specified hematopoietic: wbc at least 3,000/mm3 platelet count at least 100,000/mm3 hepatic: bilirubin less than 3 mg/dl no severe cirrhosis renal: creatinine no greater than 3.0 mg/dl cardiovascular: left ventricular cardiac ejection fraction at least 45% other: no allergy to egg or egg products not pregnant or nursing effective contraception required of all fertile patients prior concurrent therapy: biologic therapy: not specified chemotherapy: no prior doxorubicin at least 4 weeks since prior chemotherapy endocrine therapy: not specified radiotherapy: prior radiotherapy allowed surgery: not specified

Keywords: localized resectable adult primary liver cancer localized unresectable adult primary liver cancer advanced adult primary liver cancer recurrent adult primary liver cancer localized gallbladder cancer unresectable gallbladder cancer recurrent gallbladder cancer localized extrahepatic bile duct cancer unresectable extrahepatic bile duct cancer recurrent extrahepatic bile duct cancer adult primary hepatocellular carcinoma cholangiocarcinoma of the gallbladder cholangiocarcinoma of the extrahepatic bile duct adult primary cholangiocellular carcinoma
suprachoroidal buckling for the management of rhegmatogenous retinal detachment

Conditions: Retinal Detachment

Summary: study of novel surgical technic-suprachoroidal buckling for therapy of rhegmatogenous retinal detachment.it was excpted to reattached the retina and improve visual function of rhegmatogenous retinal detachment patients.

the operation was performed under a surgical microscope with a 25g chandelier light source and a wide-field observation system to observe the fundus.location, marking and freezing of the retinal tear on the scleral side . subretinal fluid is released from the outside of the sclera as needed. the spherical conjunctiva was opened and the radial full-thickness scleral incision (3mm)was made about 8-13mm away from the retinal tear. a "pocket" is formed by injecting some viscoelastic agent into the posterior edge of the sclera and separating the choroid from the sclera using the healon packaged cannula (no.27 rycroft cannula). the healon 5 syringe was connected with a 450-um special tube (a 23 caliber curved tube with olive tip). the cannula is inserted into the supragromal space under microscopic and was scaned by ioct . monitor the location of retinal tear during intubation in real time, and adjust the position of the needle: posterior margin of the tear. once confirmed in accord with the needle position, sodium hyaluronate injection, injection needles to in front of shift to injection, until the tear was completely surrounded in viscoelastic agent to create the choroid crest, usually need 0.2 ml to 0.5 ml. exit the duct and close the incision with scleral presutures.

Eligibility criteria:
inclusion criteria: * (1) clinical diagnosis of rhegmatogenous retinal detachment; (2)myopia \< 600 degrees； (3) retinal tear were peripheral part, non-proliferative round hole or horseshoe tear, single or multiple tears within one oclock area; (4) pvr grading: grade a, b, c1, c2; (5) subretinal fluid was confined around the tear. (6)phakic. exclusion criteria: * (1)cataract, corneal degeneration, genetic diseases; (2)history of internal eye surgery; (3)the other eye was blind; (4)postoperative follow-up could not be scheduled; (5)systemic diseases (asthma, heart failure, myocardial infarction, liver failure, kidney failure and other serious diseases); (6)history of aspirin and other anticoagulant drugs; (7)severe adverse reactions and systemic diseases occurred during follow-up.
pain in different office hysteroscopy diameter

Conditions: Pain Associated Office Hysteroscopy

Summary: the purpose of the investigators'study was to compare 2 different diameter rigid hysteroscopy in vaginoscopic approach regarding pain during and after the procedure. and to evaluate patient acceptability and tolerability in order to determine the best way to perform hysteroscopy in an outpatient setting.

office hysteroscopy is used as diagnostic tool to investigate abnormal uterine bleeding and other diseases involving the uterine cavity one of the main limitation to its widespread use is feared from pain and low patient tolerability narrower diameter hysteroscopy and endometrial biopsy devices are being developed to improve the acceptability of office hysteroscopy. miniature optical systems allow performance of most diagnostic and operative hysteroscopy (after proper patient selection) in an outpatient or office setting .flexible hysteroscopy seem to be less painful at the beginning and during the procedure ,but the optical qualities are poor hysteroscopy is safe, feasible and accurate procedure for diagnosing intrauterine pathology. provision of outpatient based diagnostic and operative services are gaining prominence as a standard of cure but the experience of pain can be off-putting for patients having outpatient diagnostic hysteroscopy. saline solution is an excellent alternative to carbon dioxide in women undergoing outpatient hysteroscopy, and there are fewer complications

Eligibility criteria:
inclusion criteria: * woman with nulliparous cervix exclusion criteria: * pregnancy. * female genital cancer * active pelvic infection * multipara * patient not receiving misoprostol
community development and nutrition education in banke district, nepal: effect on child health and growth

Conditions: Malnutrition

Summary: heifer project international is a globally active ngo with more than 400 projects in over 30 countries. the organization uses the introduction of livestock and related training in the development of social capital as tools for poverty alleviation, citizen empowerment, and community development. in a pilot project conducted in 2009-2012, these activities were found to promote some improvement in child health and nutritional status. however, robust enhancement of these important indicators was not observed. heifer now intends to investigate the efficacy of a nutrition and child health education program in amplifying these effects.

child health and survival remain significant challenges in nepal. nepal is ranks 63rd highest in the world for "under 5 mortality" rate, with 54/1000 children dying before their 5th birthdays and 46/1000 infants dying before their first birthdays. annually, more than 47,000 children die before reaching age 5 years. at these mortality levels, one in every 22 nepalese children dies before reaching age 1, and one in every 19 does not survive to his or her fifth birthday. nutritional status of children is extremely poor, with \~29% of children underweight and 41% stunted (respectively, weight and height \<-2 sd from median) (unicef, 2011) (ministry of health and population et al., 2012). heifer project international is a globally active ngo with more than 400 projects in over 30 countries. the organization uses the introduction of livestock and related training in the development of social capital as tools for poverty alleviation, citizen empowerment, and community development. heifer international recognizes the links between poverty, child malnutrition, and disease. however, improving economic indicators is not always sufficient to improve child outcomes. thus, the organization now wishes to conduct a systematic assessment to evaluate the effects of introducing a child health and nutrition component into their work, and to clarify the links (if any) between social capital training and child growth and health. in doing so, heifer international expects to develop a model which could be adapted for use in other regions of the world. the interaction of heifer community development activities, specific child and family characteristics, and child health and nutritional status will also be explored.

Eligibility criteria:
inclusion criteria: * child in household in designated study area of nepal, age 1 month to 12 years * family agrees to enrollment exclusion criteria: * parent refuse to enroll child

Keywords: nepal child growth nutrition education community development
hypotension prediction index for shoulder surgery in beach chair.

Conditions: Hypotension During Surgery

Summary: the beach chair position is the most commonly used position during shoulder surgery and offers the surgeon numerous advantages over the lateral decubitus position. however, the beach chair position can also lead to hemodynamic changes, including hypotension and cerebral hypoperfusion. it is therefore the anesthesiologist's job to prevent hypotension during the procedure. the acumen hypotension predictor index or hpi for short is a software program that can predict the occurrence of low blood pressure during surgery shortly before it occurs. studies have already demonstrated the effectiveness of hpi in various operations, where hypotension is defined as a mean arterial blood pressure \< 65mmhg for at least 1 minute. to our knowledge, the low blood pressure prediction index has not yet been investigated for the prevention of low blood pressure in shoulder surgery in the beach chair position. the hpi is built into a monitor that is switched on in addition to the standard monitoring for monitoring blood pressure, pulse, saturation, among other things. the monitor gives a signal when an episode of low blood pressure will occur within 15 minutes. this gives the anesthesiologist the opportunity to anticipate in time so that the occurrence of low blood pressure can be avoided. goal the aim of this study is to evaluate the efficacy of the hpi in predicting and reducing the incidence of hypotension during shoulder surgery in the beach chair position. procedure a total of 144 patients will participate in this study. patients will be randomized to the intervention group or the control group according to a 1:1 allocation. in addition to standard monitoring, the hpi monitor will be turned on for all patients. for patients in the control group, the hpi monitor screen will be blinded and the alarms muted. patients between 18 and 85 years of age with a bmi ≤ 40 kg/m2 undergoing elective shoulder surgery are eligible for the study.


Eligibility criteria:
inclusion criteria: * bmi \< 40 kg/m2 * patient can give informed consent * asa i-iv * invasive blood monitoring * general anesthesia combined with interscalene block exclusion criteria: * - refusal of participation * hypotension before surgery (map\< 65 mmhg) * history of stroke * dementia * contra-indication for interscalene block * contra-indication for general anesthesia * dialysis
intake of omega 3 in morbidly obese patients

Conditions: Morbid Obesity

Summary: ingestion of capsules of omega 3 epa and dha, with 1.8 g of epa and 1.2 g dha for morbidly obese patients, will improve the inflammatory status? c-reactive protein? weight?

intake of epa and dha for the management of morbid obesity in capsules - reduction of inflammatory factors such as adipokines, glucose, c-reactive protein, cholesterol, weight, bmi. will be 2 groups: cases and controls. the cases will intake of omega 3 capsules and placebo control.

Eligibility criteria:
inclusion criteria: * men and women aged between 18-65 years, * bmi \> 40 kg/m2 (or \> 35 kg/m2 with comorbidities), * ambulatory, receiving an oral diet, * with a diagnosis of metabolic syndrome, * and who signed a term of free and informed consent. exclusion criteria: * systemic inflammatory response syndrome, * coma or compromised organ, * fever or infection foci, * cancer with or without chemotherapy and radiotherapy, * radiotherapy, inflammatory diseases of the gastrointestinal tract, * transplant, trauma, surgery or hospital stay in the past 30 days * use of steroids or non-steroid anti-inflammatory or immunomodulators agents or antibiotics, * or those refusing to take part in the study.

Keywords: morbid obesity bmi at or above 4o kg/m2 ingestion of omega 3 inflammatory cytokines biochemical factors anthropometric factors