Kornimate/medical-research-clean huggingface dataset:
the effect of dexamethasone dosing on post-tonsillectomy hemorrhage

Conditions: Tonsillectomy; Adenotonsillectomy

Summary: this is a retrospective chart review looking at the effect of dexamethasone dosing on post-tonsillectomy hemorrhage.


Eligibility criteria:
inclusion criteria: * patients undergoing a tonsillectomy * patients undergoing an adenotonsillectomy exclusion criteria: * all patients with a known history of bleeding or clotting disorders, as well as those patients who had presented to nationwide children's hospital main operating room for control of pth but had their initial tonsillectomy/adenotonsillectomy at an outlying facility will be excluded from the study.
examining the effect of different diuretics on fluid retention in diabetics treated with rosiglitazone.

Conditions: Diabetes Mellitus

Summary: study examining the effect of different diuretics on fluid retention in diabetics treated with rosiglitazone.

a randomised, open-label, parallel group study to evaluate the management of rosiglitazone-related fluid retention by investigating the effect of diuretics on plasma volume in subjects with type 2 diabetes mellitus treated for twelve weeks with rosiglitazone 4mg bd in addition to background anti-diabetic agents.

Eligibility criteria:
inclusion criteria: * subjects with type 2 diabetes. * stable fpg of \>=7.0 and \<=12.0mmol/l. * subjects had to have been established on su treatment or su+met treatment for at least 2 months. * serum creatinine level \> 130 micromol/l. exclusion criteria: * subjects taking \> 2 concomitant oral anti-diabetic agents. * subjects with hba1c \>=10%. * subjects already receiving diuretic medication. * subjects unstable or severe angina. * chf nyha class i-iv. * subjects with clinically significant hepatic disease.

Keywords: rosiglitazone fluid retention type 2 diabetes diuretics
evaluation of insecticide treated nets and wall liners for the prevention of malaria

Conditions: Malaria

Summary: the purpose of this study is to determine whether insecticide treated wall liners, in combination with insecticide treated nets, reduce the incidence of malaria infections compared to insecticide treated nets alone.

insecticide treated nets (itns) have been shown to reduce malaria related morbidity and mortality and are increasingly being scaled up throughout sub-saharan africa. however, itns alone are unlikely to reduce transmission to zero in most settings and additional vector control tools are necessary. one new promising strategy is the use of insecticide treated wall liners (itwls). these are textiles treated with an insecticide that are used to line the inner walls of houses. the wall liners are considered a long-lasting alternative to indoor residual spraying which is also used for malaria vector control but is expensive to implement. within 6 pairs of villages, we plan to randomly allocate one village in each pair to receive either itns or itns plus itwls. households will be randomly selected from each village and all children between the ages of 6 months and 11 years will be enrolled in a cohort study. the children will be cleared of existing infections and then followed monthly until they are found to be infected with malaria. the study will last for 6 months and will demonstrate whether the itwls provide additional protection against malaria over that provided by the use of itns.

Eligibility criteria:
inclusion criteria: * age 6 months up to 11 years * living in the study area and remaining in the study area for the duration of the study * informed consent provided by parents exclusion criteria: * no informed consent * living outside the study area, or likely to move outside study area * severely ill and unlikely to be able to complete study

Keywords: insecticide treated wall liners insecticide treated nets incidence cohort
fenofibrate as a metabolic intervention for covid-19

Conditions: Covid19

Summary: the severe acute respiratory syndrome coronavirus 2 (sars-coc-2), the virus responsible for coronavirus disease 2019 (covid-19), is associated with a high incidence of acute respiratory distress syndrome (ards) and death. aging, obesity, diabetes, hypertension and other risk factors associated with abnormal lipid and carbohydrate metabolism are risk factors for death in covid-19. recent studies suggest that covid-19 progression is dependent on metabolic mechanisms. moreover, gene expression analyses in cultured human bronchial cells infected with sars-cov-2 and lung tissue from patients with covid-19, indicated a marked shift in cellular metabolism, with excessive intracellular lipid generation. in this cell culture system, fenofibrate (a widely available low-cost generic drug approved by the fda and multiple other regulatory agencies around the world to treat dyslipemias) at concentrations that can be achieved clinically, markedly inhibited sars-cov-2 viral replication. fenofibrate also has immunomodulatory effects that may be beneficial in the setting of covid-19. the aim of this trial is to assess the clinical impact of fenofibrate (145 mg/d of tricor or dose-equivalent preparations for 10 days, with dose adjustment in chronic kidney disease (\[ckd\]) to improve clinical outcomes in patients with covid-19.


Eligibility criteria:
inclusion criteria: * a diagnosis of covid-19, based on: (a) a compatible clinical presentation with a positive laboratory test for sars-cov-2, or (b) considered by the primary team to be a person under investigation undergoing testing for covid-19 with a high clinical probability, in addition to compatible pulmonary infiltrates on chest x-ray (bilateral, intersticial or ground glass opacities) or chest ct. * able to provide informed consent. * fewer than 14 days since symptom onset. exclusion criteria: * known pregnancy or breastfeeding * estimated glomerular filtration rate (egfr) \<30 ml/min/1.73m2 or undergoing dialysis (ckd stages 4-5). * history of active liver disease, cholelithiasis, uncontrolled hypothyroidism, or rhabdomyolysis (suspected or confirmed). patients with a history of hypothyroidism receiving a stable dose of thyroid replacement therapy for at least 6 weeks, with a documented normal tsh (primary hypothyroidism) or free thyroxine (secondary or tertiary hypothyroidism) level at least 6 weeks after the last dose change will be considered eligible for enrollment. * known hypersensitivity to fenofibrate or fenofibric acid. * ongoing treatment with fenofibrate, clofibrate, warfarin and other coumarin anticoagulants, glimepiride, cyclosporine, tacrolimus * use of statins other than simvastatin, pravastatin or atorvastatin ≤40 mg/d or rosuvastatin ≤20 mg/d * prisoners/incarcerated individuals * inability to read, write or no access to a smart phone, computer or tablet device * intubated patients.
mindfulness-based therapeutic sailing (mbts) versus standard recreation therapy activity (srt)

Conditions: Psychiatric Disorder; Substance Use Disorders

Summary: this study will be a prospective randomized controlled trial (rct) of mindfulness-based therapeutic sailing (mbts) versus a standard recreation therapy activity (bowling) among veterans with psychiatric and/or substance use disorders. the specific aims of this investigation are to determine whether: 1. mbts will result in greater pre- to post-intervention increases in psychological flexibility and state mindfulness than a standard recreation therapy activity (srt). 2. mbts participants will experience greater enjoyment of the activity than srt participants. 3. mbts will result in greater pre- to post-intervention increases in positive affect and decreases in anxiety as measured as compared to the srt participants. 4. mbts participants will exhibit improved outcomes, as compared to the srt group, in the 3-month post-intervention period.


Eligibility criteria:
inclusion criteria: * at least one psychiatric or substance use disorder * at least one mental health service appointment within the previous 12 months exclusion criteria: * active psychosis * significant cognitive impairment and/or physical impairment that would preclude participation in the activities * previous participation in a therapeutic sailing intervention offered by the va salt lake city health care system.

Keywords: psychiatric disorder substance use disorders sailing bowling
community-based complex exercise for stroke patients

Conditions: Stroke; Exercise

Summary: a lot of physical and social effects of exercise programs and daily physical education have already been proven for stroke patients after discharge. however, stroke patients have shown a passive attitude in participating in physical education or exercise programs for life, and the local community lacked appropriate guidelines or experience in guiding exercise and physical education for stroke patients, so they had a burden on instructing exercise. in this study, an appropriate complex exercise program was established for patients after discharge through analysis of domestic and foreign research data to provide an environment and opportunity to exercise in the community, and based on the results, stroke patients actively exercise in the community in the future. the goal is to provide a basis for doing so.


Eligibility criteria:
inclusion criteria: * stroke patients aged 30 years or older residing in the community * those who can walk independently and have a score of 3 or higher in the functional ambulation category (fac) * the daily life dependence of the stroke patient is a person who can perform simple tasks necessary for daily life, those who scored 2 points or less on the modified rankin scale (mrs) * subjects with no or mild stiffness of the affected upper and lower limbs, with a score of 1 or less on the modified ashworth scale (mas) * all 3 major joints of the affected upper and lower limbs (manual muscle test (mmt)) are 3 points (f grade) or higher ruler exclusion criteria: * with moderate or severe cognitive dysfunction, korean-mini mental state test (korean-mini mental state test) those who scored less than 18 points in the examination (k-mmse) * a person with a moderate or higher fall risk and less than 41 points on the berg balance scale (bbs) * those who have difficulty understanding the intervention exercise program or expressing symptoms due to severe language impairment * those who cannot apply this intervention exercise program due to serious cardiovascular disease * those who have musculoskeletal disorders that make it impossible to exercise * those who are judged unsuitable for this study under the judgment of a specialist in rehabilitation medicine due to other diseases
safety and efficacy of allo-715 bcma allogenic car t cells in in adults with relapsed or refractory multiple myeloma (universal)

Conditions: Relapsed/Refractory Multiple Myeloma

Summary: the purpose of the universal study is to assess the safety, efficacy, cell kinetics, and immunogenicity of allo-715 with or without nirogacestat in adults with relapsed or refractory multiple myeloma after a lymphodepletion regimen of allo-647 in combination with fludarabine and/or cyclophosphamide, or allo-647 alone.


Eligibility criteria:
inclusion criteria: * documented diagnosis of relapsed/refractory multiple myeloma (mm) with measurable disease (serum, urine, or free light chain \[flc\]) per international myeloma working group (imwg) criteria * at least 3 prior lines of mm therapy, including a proteasome inhibitor, immunomodulatory agent, and anti-cd38 antibody (unless contraindicated), and refractory to the last treatment line. * eastern cooperative oncology group (ecog) 0 or 1 * absence of donor (product)-specific anti-hla antibodies * adequate hematologic, renal, hepatic, pulmonary, and cardiac function exclusion criteria: * current or history of central nervous system (cns) involvement of myeloma or plasma cell leukemia * clinically significant cns disorder * current or history of thyroid disorder * autologous stem cell transplant within the last 6 weeks, or any allogeneic stem cell transplant * prior treatment with anti-bcma therapy, any gene therapy, any genetically modified cell therapy, or adoptive t cell therapy * history of hiv infection or acute or chronic active hepatitis b or c infection * patients unwilling to participate in an extended safety monitoring period additional exclusion criteria for nirogacestat plus allo-715 cohorts * inability to swallow tablets * subject has known malabsorption syndrome or preexisting gastrointestinal conditions that may impair absorption of nirogacestat * use of strong/moderate cyp3a4 inhibitors, and strong cyp3a4 inducers within 14 days before starting nirogacestat. * use of concomitant medications that are known to prolong the qt/qtcf interval
prehospital tee in cardiac arrest

Conditions: Echocardiography, Transesophageal; Out-of-Hospital Cardiac Arrest

Summary: this study shall investigate the feasibility of prehospital performed trans-esophageal echocardiography in out of hospital cardiac arrest. the investigators will include ten patients undergoing advanced life support in this study and determine if it is possible to acquire adequate trans-esophageal images within 10 minutes after arrival of the study team on scene.

out of hospital cardiac arrest (oohca) remains a leading cause of death in austria. current guidelines recommend to address potentially reversible causes for oohca early to improve survival and some of these causes can be recognized using echocardiography. the usefulness of trans-thoracic echocardiography during oohca seems to be limited as image acquisition may prolong now flow time and image quality is variable. these limitations might be overcome with trans-esophageal echocardiography. the investigators will investigate the feasibility of prehospital performed trans-esophageal echocardiography in ten oohca patients undergoing advanced life support. in addition to routine care by paramedics and emergency physicians, a dedicated expert in emergency ultrasound will perform trans-esophageal echocardiography in these patients. primary outcome parameter: is it possible to obtain trans-esophageal images of the heart within 10 minutes after arrival of the study team?

Eligibility criteria:
inclusion criteria: * adult patients undergoing advanced life support for out of hospital cardiac arrest exclusion criteria: * patients who should undergo rapid transport to the hospital with ongoing cpr (ecmo candidates, pregnant, trauma, obvious reversible which can be treated in hospital only) * known esophageal pathology contraindicating tee * no definite secure airway present (endotracheal intubation, tracheostomy)
intraarticular xylitol injections for knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: hypothesis: intraarticular injections of isotonic xylitol solution will improve pain in patients with knee osteoarthritis (oa).


Eligibility criteria:
inclusion criteria: * age over 45 * tibiofemoral osteoarthritis * oa stage 2-3 on xray * pain vas \> 40mm * no nsaids for 3 weeks * no analgetics for 38 hours exclusion criteria: * pain vas \> 80mm * pain vas in contralateral knee \> 40mm * inflammatory arthritis * severe effusion * posttraumatic osteoarthritis * unstable knee * isolated patellofemoral disease * paracetamol hypersensitivity
effects of functional exercise versus high frequency transcutaneous electrical nerve stimulation on primary dysmenorrhea

Conditions: Primary Dysmenorrhea

Summary: the objective of this study is to assess the impacts of utilitarian exercise versus high frequency anscutaneous electrical nerve stimulation on pain and sleep quality in students with primary dysmenorrhea.

a randomized control trial study will be directed at riphah international university faisalabad after synopsis approval. the purposive examining method will be utilized to enlist the patients. patients will be enrolled according to the pre-characterized criteria. sample size for this examination is 40 females (18 yrs - 30 yrs) as per determination measures. the patients of one group will recieve exercise therapy and patients of other group will recieve high frequency transcutaneous electrical nerve stimulation. the patient's result will be assessed following a month of treatment . informed consent will be taken from each patient. data entry and analysis will be done with statistical package of social sciences version 20.

Eligibility criteria:
inclusion criteria: 1. diagnosed instance of primary dysmenorrhea 2. age somewhere in the range of 18 and 30 years, 3. a history of lower stomach torment for in excess of 6 periods. 4. moderate or serious torment, with a numeric rating scale (nrs) score ≥5 out of 10. 5. no elective treatment including tens inside multi month before enlistment in the investigation; and 6. provision of educated agree preceding enlistment in the examination. exclusion criteria: 1. pregnant or breastfeeding, 2. history of medical procedure of the lower midsection, 3. heart sickness, 4. cancer, 5. severe mental problems. 6. those who couldn't utilize tens, for instance, in view of a lasting pacemaker or skin infection.

Keywords: functional exercise high frequency transcutaneous electrical nerve stimulation primary dysmenorrhea menstrual pain randomized control trial
renal response to lower body negative pressure in pre-hypertensive states

Conditions: Hypertension; Obesity; White Coat Hypertension; Resistant Hypertension

Summary: the purpose of this study is to determine whether in pre-hypertensive and hypertensive states such as white coat hypertension, obesity related hypertension or resistant hypertension, renal function is more sensitive to orthostatic stress.


Eligibility criteria:
inclusion criteria: * bmi \> 30 kg/m2 (obesity group) * office bp \>140/90 and daytime ambulatory blood pressure \ 135/85 mm hg or nighttime abpm 120/70 exclusion criteria: * history of allergic reaction * diabetes type 1 or type 2 * history of renal artery stenosis * acute illness

Keywords: hypertension obesity white coat hypertension resistant hypertension
assessment of occult lung stress during lung protective mechanical ventilation

Conditions: Acute Respiratory Distress Syndrome

Summary: the present study will utilize esophageal manometry to measure the presence and magnitude of persistent patient effort during lung protective ventilation, allowing identification and mitigation of occult lung stress.


Eligibility criteria:
inclusion criteria: * intubated with a diagnosis of ards and expected to be ventilated for ≥ 48 hours * meets berlin criteria for ards, with or without underlying chronic lung disease * triggering breaths on the ventilator * treating medical team agrees with patient participation exclusion criteria: * known or suspected esophageal abnormalities, craniofacial abnormalities, or upper gi bleed * shock that requires ≥ 2 vasopressors * ph on arterial blood gas ≤7.25 * minute ventilation ≥ 14l/min * known or suspected pneumothorax, pneumomediastinum, and/or subcutaneous emphysema * severe ards with p/f ratio \<60 * pregnancy * currently receiving extracorporeal membrane oxygenation (ecmo) therapy * decision to withhold life-sustaining treatment * patients who are not expected to survive for 24 hours * lack of informed consent
bleach and urine color in uc patients using 5asa

Conditions: Ulcerative Colitis

Summary: the aim of this study is to evaluate the effect on urine color by adding household bleach to fresh urine sample among pediatric uc subjects treated with 5asa

the aim of this study is to evaluate the effect on urine color by adding household bleach to fresh urine sample among pediatric uc subjects treated with 5asa.

Eligibility criteria:
inclusion criteria: 1. uc patients in remission exclusion criteria: 1. acute uc exacerbation defined as pediatric ulcerative colitis activity index (pucai) ≥10 2. any acute or chronic renal disease, either present or past 3. chronic hypertension, either present or past 4. regularly receiving other medication that may cause nephrotoxicity - non-steroidal anti-inflammatory drugs, acetaminophen, anti-epileptics, and antibiotics. 5. pregnancy

Keywords: hematuria urine 5-aminosalycilic acid
ex onc sled: a study utilizing a weighted sled for horizontal resistance training

Conditions: Cancer

Summary: this protocol seeks to analyze patient adherence and outcomes after monitored exercise sessions utilizing primarily weighted sled pushes and pulls for linearly progressed resistance training of individuals who have been diagnosed with cancer.


Eligibility criteria:
inclusion criteria: 1. age 20-89 years 2. women of child-bearing potential must verbally confirm lack of pregnancy prior to enrollment. they should also consent to use adequate contraception during the course of the study. 3. participants must be determined capable of engaging in resistance training by exercise personnel and/or study pi and must be able to stand. 4. participants must complete an assessment by eoc staff and be determined safe to engage in the workout regimen by the study exercise personnel. any individuals not deemed safe to participate in the basic eoc exercise program will be referred to physical therapy or elsewhere exclusion criteria: 1. severe arthritic, joint, cardiovascular, or musculoskeletal condition that would interfere with exercise program 2. individuals deemed able to engage in more intense resistance training utilizing compound movements will not be eligible 3. pregnant women

Keywords: exercise resistance training
desivi: dosing of electrical stimulation in venous insufficiency

Conditions: Varicose Veins; Venous Stasis; Venous Insufficiency

Summary: this study is designed to describe the difference in varicose vein outcomes found from using a neuromuscular electrical stimulation device for different amounts of time - group a (control - no device), group b (device for 30 mins per day) and group c (device for 60 mins per day). the groups are assessed after 6 weeks of intervention.


Eligibility criteria:
inclusion criteria: patients with chronic venous insufficiency who have the following are eligible for the study: * able to understand the study and provide meaningful written informed consent for the study. * willing, able, and committed to participate in the procedures for the full length of the study. * all ethnic groups, male or female above the age of 18 years. * diagnosis of chronic venous insufficiency (c3-c5 ceap classification) * blood pressure currently under moderate control (\< 160/100mmhg) * no current foot ulceration exclusion criteria: patients meeting any of the following criteria are to be excluded: * has an unstable condition (eg, psychiatric disorder, a recent history of substance abuse) that would affect compliance with protocol * pregnant * has a cardiac pacemaker, aicd or other implanted electrical device * has an existing dvt. * has recent lower limb injury or lower back pain * has current foot ulceration or other skin ulcers * has any disorder that, in the opinion of the investigator, might interfere with the conduct of the study. * has an abpi \< 0.8

Keywords: venous