Kornimate/medical-research-clean huggingface dataset:
study of a structured parent intervention on adolescent weight loss modification program.

Conditions: Pediatric Obesity; Impact of Parent Intervention on Adolescent Weight Loss

Summary: the study will enroll 110 overweight and obese adolescents ages 11-16 in a lifestyle modification program focusing on dietary modification and exercise. parents will be randomized into control and motivational interviewing-based intervention groups. the primary hypothesis is that adolescents whose parents are in the intervention group will have improved compliance, weight loss and health outcomes compared with adolescents whose parents do not receive the intervention.

adolescents will participate in a 6-month intensive lifestyle modification that includes a structured exercise program, nutrition education and dietary modification and behavioral support, followed by a 6-month maintenance phase with monthly booster sessions. parents will be randomized to participate in 4 dedicated "pre-treatment" parent psychoeducational sessions vs. control (no psychoeducational sessions). the sessions will explore parents' feelings about participation in a weight management program, explore their reasons for wanting to make behavioral changes, and enhance motivation. all parents will participate in monthly parent support groups while their adolescents are participating in the intervention phase of the study. the 6-month adolescent intervention will include biweekly sessions with a registered dietitian for dietary education; biweekly interactive group discussion sessions on topics pertaining to motivation, strategies for changing health behaviors, setting and keeping goals and dealing with peer pressure; and exercise sessions three times a week with 30 minutes of cardiovascular exercise and 30 minutes of strength training each session. comprehensive assessments, including nutrition, behavior and exercise assessments, laboratory work, body composition measurements and medical assessments will be conducted at baseline, 6 months and 12 months.

Eligibility criteria:
inclusion criteria: age 11 - 16; bmi \> 85th percentile; one parent or guardian committed to participate in protocol; - exclusion criteria: previous enrollment in irb3354, irb3008 or hm11113; underlying genetic, neurological, endocrine or metabolic condition that preclude weight loss with conventional diet and exercise programs; weight greater than 400 pounds, pregnancy in female subjects; inability to understand study instructions due to language barrier or mental disability; primary residence outside a 30 mile radius of study location. -

Keywords: pediatric obesity motivational interviewing lifestyle intervention
symptomatic, biomechanical and radiographic outcomes in knee osteoarthritis following gastric bypass surgery

Conditions: Obesity; Osteoarthritis

Summary: weight is a risk factor for knee osteoarthritis knee osteoarthritis is associated with abnormal gait biomechanics gait biomechanics are evaluated in gastric bypass patients before and after losing 100 pounds.

weight is a major risk factor for development of knee osteoarthritis, but not hip or ankle arthritis. one possible mechanism for this is the generation of abnormal gait biomechanics secondary to obesity that are conducive to the development of knee osteoarthritis. we evaluate gait biomechanics, knee symptoms and knee radiographs in 35 obese patients before and after gastric bypass surgery to determine the effect of significant weight loss on gait biomechanics, knee symptoms and knee radiographs.

Eligibility criteria:
inclusion criteria: undergoing gastric bypass surgery at least 35 years old - exclusion criteria: inability to walk unassisted pain affecting gait in any lower extremity joint -

Keywords: obesity gait biomechanics knee osteoarthritis
evaluate the accuracy of the nbm200 for noninvasive hemoglobin measurements on obstetric/gynecological patients

Conditions: Anemia

Summary: the purpose of the study is to define the precision, accuracy and variability of the nbm-200 system in non invasive blood hemoglobin (hb) measurements relative to the laboratory blood analyzer by comparing two consecutive hb values obtained by the nbm system to venous values.

each subject will be placed in a comfortable position in a temperature regulated room. participants will have two consecutive non invasive (nbm) measurements taken which involves inserting the thumb into a ring shaped sensor. after each non invasive measurement the sensor will be removed. each measurement takes approximately 85 seconds and involves the finger cuff inflating (to over systolic pressure) and deflating several times in quick successions in order to measure and calculate the hb values. the two non invasive measurements will be performed using the same finger. after the nbm system testing is complete and recorded, the subject will have a venous (venipuncture) blood sample collected in order to provide two blood tests performed on two different models of routine automated cbc or hb blood analyzers.

Eligibility criteria:
inclusion criteria: * female volunteers aged 18 years and over. * any patient subject to cbc testing according to obgyn standard care and clinical judgment. exclusion criteria: * participants under the age of 18 years * significant deformity, degenerative changes or edema of the thumb or index fingers * localized infection, ulceration or skin breaks involving the fingers * low peripheral body temperature (tissue perfusion) \<36.0˚c * vascular disease or raynaud's phenomenon affecting the fingers * participants who are unable to give informed written consent

Keywords: accurate hb noninvasive measurement
a study of gdc-0575 alone and in combination with gemcitabine in participants with refractory solid tumors or lymphoma

Conditions: Lymphoma, Solid Tumor

Summary: this open-label, multicenter, phase i, dose-escalation study will evaluate the safety, tolerability, and pharmacokinetics (pk) of gdc-0575 administered alone or in combination with gemcitabine in participants with refractory solid tumors or lymphoma. in stage 1, cohorts of participants will receive multiple ascending oral doses of gdc-0575 alone or in combination with intravenous gemcitabine. in stage 2, participants will receive gdc-0575 orally in combination with intravenous gemcitabine at or below the maximum tolerated dose determined in stage 1. anticipated time on study treatment is until disease progression or unacceptable toxicity occurs, up to approximately 5 years.


Eligibility criteria:
inclusion criteria: * eastern cooperative oncology group (ecog) performance status 0-1 * histologically or cytologically documented, locally advanced or metastatic solid tumors or lymphoma for which standard therapy either does not exist or has proven ineffective or intolerable * life expectancy greater than or equal to (\>=) 12 weeks, in the opinion of the investigator * adequate hematologic, liver, and renal function * for stage 2: participants with human epidermal growth factor receptor 2 (her2) negative, estrogen-receptor (er) negative, and progesterone-receptor (pr) negative breast cancer * for stage 2: participants with non-mucinous, platinum-resistant ovarian cancer with documented radiographic progression or relapse according to recist within 6 months of receiving platinum-based chemotherapy * for stage 2: participants with histologically or cytologically confirmed diagnosis of squamous non-small cell lung cancer (nsclc); mixed histology that is predominantly squamous is acceptable exclusion criteria: * history of prior significant toxicity from a same class of agents as gdc-0575 or gemcitabine requiring discontinuation of treatment * all acute toxicities related to prior therapy must have resolved prior to study entry, except for alopecia and mild neuropathy * current severe, uncontrolled systemic disease (including but not limited to clinically significant cardiovascular, pulmonary, or renal disease or ongoing or active infection) excluding the cancer under study * history of significant cardiac dysfunction * history of malabsorption or other condition that would interfere with enteral absorption * known human immunodeficiency virus (hiv) infection * pregnancy, lactation or breastfeeding * known brain metastases that are untreated, symptomatic, or require therapy to control symptoms * current use of alpha-adrenergic receptor blockers for combination arm only: * any contraindication to gemcitabine therapy * more than two regimens of cytotoxic chemotherapy for the treatment of locally advanced or metastatic cancer * history of receiving high-dose chemotherapy requiring bone marrow or stem cell support * irradiation to more than 25% of bone marrow-bearing areas
australian university of california san francisco (ucsf) concussion in athletes (aussie-2)

Conditions: Concussion, Mild

Summary: analysis of cardiac induced brain forces using cranial accelerometry has been shown to diagnose concussion in high school athletes. this trial expands on this observation by recording headpulse signals in a recently concussed athletes playing australian rules football.

recently concussed athletes will have headpulse measurements obtained as soon after the clinically identified concussion as is feasible and at 1-3 day intervals over the course of a month. these recordings will pair with a self administered neurological symptom inventory (nsi) to track the athletes subjective concussion symptoms. data from the prior study (aussie-1) will be used to confirm the predictive value of the established algorithm

Eligibility criteria:
concussion subjects: inclusion criteria: * diagnosed with sport related concussion * first recording obtained within one week * willingness to have multiple recordings in the month following concussion exclusions: - head laceration control subjects: inclusion criteria * athletes without concussion over the last year * willingness to have single or multiple recordings exclusion criteria: * head laceration

Keywords: headpulse mtbi
the effectiveness of low-level laser therapy in orthodontic retention for periodontal-compromised patients

Conditions: Orthodontics; Periodontal Diseases

Summary: the aim of the study is to evaluate the effects of low-level laser therapy (lllt) on patients with chronic periodontitis during a post-orthodontic period for 12 months. following aspects will be assessed: 1. effects on tooth stability maintenance and bone remodeling. 2. effects on periodontal inflammation status. 3. effects on cervical dentin sensitivity and quality of life. the study design is a randomised controlled trail. to eliminate any bias, the investigator will initially hypothesis there is no significant difference in the aforementioned aspects between teeth retained with an adjunctive lllt strategy and those retained in a conventional regimen.

the study design is a randomised split-mouth design based on the result of investigator's pilot study. thirty-five non-smoking ethnic chinese patients (male and female, age: 25-65 years) with chronic periodontitis will be recruited. the teeth in experimental group will receive lllt during orthodontic retention period for 12 months, while the teeth in the control (placebo) group will not receive laser therapy. orthodontic occlusal indices will be measured to explore lllt's role in maintaining tooth stability. the effects of lllt on periodontal inflammation status will be evaluated by assessing clinical periodontal parameters and the levels of supra-gingival and sub-gingival bacteria. the effects of lllt on bone remodelling will be explored by testing the biochemical biomarkers in gingival crevicular fluid (gcf). cone-beam computed tomography will also be used to provide clinical evidence of periodontal status and bone remodelling. possible effects of lllt on patient's quality of life will be investigated via validated questionnaires, subjective assessment of tooth sensitivity, and objective measurement of bite force.

Eligibility criteria:
inclusion criteria: thirty-five non-smoking ethnic chinese patients (male or female; age: 25-65 years) will be recruited from the prince philip dental hospital, faculty of dentistry, the university of hong kong into the following selection criteria: 1. systemically health (with special regard to disease affecting tissue repair); 2. no medications required for periodontal therapy and no use of any antibiotic and/or anti-inflammatory medication in the preceding month; 3. chronic periodontitis with at least two pairs (clinically matched) displaced single-rooted teeth (each pair of teeth is in the same arch but in two contralateral hemi-arches respectively belonging to the same tooth typology) having at least one site probing depth of 5 mm or more, interproximal attachment loss of 3 mm or more, and radiographic signs of alveolar bone loss before periodontal and orthodontic treatment. 4. recent completion of orthodontic treatment and readiness for debonding and retainer delivery. exclusion criteria: 1. smoking; 2. pregnancy; 3. under orthodontic treatment.

Keywords: low-level laser therapy orthodontic retention periodontal disease
swedish national benchmarks in laparoscopic bariatric surgery

Conditions: Bariatric Surgery

Summary: the aim of this observational study is to define national reference values, according to the achievable benchmarks of care method (abc™), for laparoscopic bariatric surgery in sweden. the primary outcome is to identify the best possible, yet achievable, results during and after bariatric surgery. the second outcome to investigate if there are risk groups for complications, and if so perform risk-adjusted benchmark-calculations.

the data source will be the scandinavian obesity surgery registry (soreg), a prospective quality registry for obesity surgery. the time frame will be 2012-2021. the techniques to be investigated are laparoscopic roux-en-y gastric bypass and laparoscopic gastric sleeve respectively. register variables related to surgical quality will be analyzed, and related to risk of peroperative and postoperative complications. the study will analyze data for the time of surgery and up to one year after surgery.

Eligibility criteria:
inclusion criteria: * adults ≥ 18 years of age * primary laparoscopic gastric sleeve or primary laparoscopic roux-en-y gastric bypass exclusion criteria: * other organ surgery at the time of the index operation * no data about surgery * no data about follow-up

Keywords: obesity bariatric surgery laparoscopy benchmarking
strengthening inspiratory and oropharyngeal muscles in moderate obstructive sleep apnea hypopnea syndrome

Conditions: Obstructive Sleep Apnea

Summary: the obstructive sleep apnea hypopnea syndrome (osas), whose prevalence is 4% of the french population, can lead to serious health consequences (risk of road accidents, onset of cardiovascular disease, etc.). osas corresponds to a certain number of interruptions (apneas) or reductions (hypopneas) of ventilation during sleep. the weakening of the tone of the inspiratory and oropharyngeal muscles is one of the main causes of upper airways obstruction during the inspiratory phase.

for patients with moderate osas, with few or no symptoms, without associated cardiovascular comorbidities, there is no recommended treatment. rehabilitate the inspiratory and oropharyngeal muscles through muscle strengthening seems to be an alternative to this problem. therefore, this study proposes a complete rehabilitation care evaluating the effectiveness of the strengthening of inspiratory and oropharyngeal muscles in subject with moderate osas.

Eligibility criteria:
inclusion criteria: * moderate sahos (15 ≤ ahi ≤30); * body mass index (bmi) \< 35 ; * patient affiliated or entitled to a social security scheme; * patient having signed a consent to participate in the study. exclusion criteria: * excessive daytime sleepiness: epworth sleepiness score \> 10 ; * professional driving and history of accidents related to sleepiness; * severe obstructive or restrictive ventilatory disorders of neuromuscular origin authenticated by respiratory function tests; * patients undergoing treatment for osas or requiring immediate initiation of continuous positive airway pressure (cpap) or a mandibular advancement orthosis; * patients who have stopped cpap or orthosis treatment in less than one month; * patients undergoing cardiorespiratory exercise rehabilitation or starting regular physical training; * uncompensated heart failure, thoracic sternotomy surgery \< 4 months; * marked osteoporosis with history of rib fractures; * history of spontaneous pneumothorax; * severe asthma;

Keywords: inspiratory muscles training oropharyngeal training
hemodynamic effect of nasal high-flow in patients suspected or followed for a precapillary pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: in this study, the investigators aim to describe the hemodynamic consequences of nasal high-flow measured during right heart catheterization and echocardiography. the research hypothesis is that nasal high-flow would increase cardiac output in patients with pulmonary hypertension. the concomitant echocardiography will allow to describe its sensibility to detect cardiovascular consequences of nasal high-flow.


Eligibility criteria:
inclusion criteria: - patient addressed for right heart catheterization for pulmonary hypertension suspicion or follow-up. exclusion criteria: * necessity of fio2 \>21% during right heart catheterization * intracardiac shunt * grade 4 tricuspid insufficiency * complete arrhythmia due to atrial fibrillation * pregnant or breastfeeding women or women of childbearing age without an effective method of contraception * protected adult patient (tutorship or curatorship) * patient deprived of liberty by court or administrative decision * refusal of patient participation or consent * patient for whom the measurement of pulmonary arterial pressures during right heart catheterization is impossible * patient for whom, during the etiological assessment of pulmonary hypertension, the diagnosis of precapillary pulmonary hypertension cannot be confirmed and classified in groups 1, 3 or 4.

Keywords: high-flow nasal cannula therapy hemodynamic monitoring echocardiography right heart catheterization
evolution of multiple primary lung cancer (evolution)

Conditions: Multiple Primary Lung Cancers; Lung Cancer; Non Small Cell Lung Cancer

Summary: to investigate the evolutionary genomic landscape, explore the genetic tumor heterogeneity and microenvironment of multiple primary lung cancer (mplc) by using tissue genetic analysis and circulating tumor dna detection, in order to provide robust evidence for the diagnosis, treatment, and surveillance of mplc.

multiple primary lung cancer (mplc) has become a worldwide problem due to the difficulty in diagnosis, treatment and surveillance. although exploring tumour clonal heterogeneity and microenvironment can help understand cancer evolution and impact therapeutic outcome, study is still lacking in this field on mplc. circulating tumor dna (ctdna) are short dna fragments, which can be obtained conveniently and non-invasively, providing comprehensive views of the tumor as were shed by tumor cells from multiple tumor regions. therefore, we design a prospective study of patients with surgically treated mplc, aiming to use ctdna technique to define the evolutionary landscape of mplc through inter-tumor and intra-tumor heterogeneity by multi-region sampling and genetic analysis. we will also explore the the microenvironment by rna sequencing and t cell receptor sequencing. this study may help understand the genetic evolution and microenvironment of mplc, and provide evidence for the diagnosis, treatment and surveillance of these patients.

Eligibility criteria:
inclusion criteria: * aged 18 to 80 years 1. patients who are clinically diagnosed multiple lung cancers, and undergo surgical treatment. 2. no history of any malignancy in recent 5 years. 3. no chemotherapy, radiotherapy or targeted therapy will be performed before surgery. 4. surgical removal of at least 2 tumors confirmed to be lung cancer postoperatively by pathologic evaluation. exclusion criteria: 1. all lesions present as pure ground-glass opacities (ggos) on ct scans. 2. patients who do not undergo r0 resection (including tumors located bilaterally but only unilaterally resected). 3. unqualified blood samples. 4. unable to comply with the study procedure

Keywords: multiple primary lung cancer ctdna evolution tumor heterogeneity microenvironment
efficacy and tolerability of a nutritional supplement, plactive progen, in acl reconstruction

Conditions: ACL Reconstruction

Summary: this was a prospective, multicenter, randomized, open-label, phase iv trial to compare the efficacy of supplementation with plasma proteins, hydrolyzed collagen (ch), a complex of ha-cs (hc-15), and vitamin c combined with a standard rehabilitation protocol versus the standard rehabilitation protocol only after arthroscopically-assisted functional acl reconstruction with hamstrings.


Eligibility criteria:
inclusion criteria: * subjects aged between 18 and 55 years with partial or complete anterior cruciate ligament (acl) rupture, diagnosed clinically and by magnetic resonance imaging (mri), requiring reconstructive surgery. * patients with symptoms of acute or subacute acl rupture (such as inflammation of the knee and pain with leg movement) or chronic acl tear, including instability of the knee. * patients with acl ruptures without osteochondral lesions requiring additional surgery. * patients with a medical history of therapeutic benefit using analgesic agents. exclusion criteria: * patients with concomitant osteochondral pathology. * patients treated with intra-articular injections of corticosteroids and/or platelet-rich plasma, or with oral glucosamine, cs, ha or ch in the two months prior to surgery. * patients with systemic diseases, those treated with antibiotics or other drugs that might alter the healing process, and those who had undergone arthroscopic lavage in the 90 days prior to surgery.

Keywords: anterior cruciate ligament tears dietary supplementations plasma rich proteins collagen chondroitin sulfate hyaluronic acid