Kornimate/medical-research-clean huggingface dataset:
traditional chinese and western medicine for knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: a cohort study will be used to collect patient data, analyze the clinical characteristics, traditional chinese medicine (tcm) syndromes, and treatment of knee osteoarthritis (koa) in china to accumulate clinical data and clarify the status of koa in the real world background. it will lay a clinical foundation for further study of koa in the future, and bring certain clinical value for chinese patients with koa.

this is a multicenter cohort study. it is planned to carry out multicenter investigation and research on the current situation of knee osteoarthritis in the real world, conduct large-scale investigation on the clinical population of patients with knee osteoarthritis, and establish a research, quality control, data management and statistical analysis platform for the clinical practical application of knee osteoarthritis and hospital registration. this study aims to discover the current clinical characteristics, tcm syndromes, and treatment status of patients with knee osteoarthritis in china, and provide reliable data support for the clinical treatment of koa. it is estimated that 5000 patients from 23 centers across china will be recruited. various demographic and disease-related information will be documented, including name, gender, age, job category, disease course, medical consultation experience, treatment satisfaction and so on. patients will also complete a series of scales, containing visual analog scale (vas) score, knee injury and osteoarthritis outcome score (koos), western ontario and mcmaster universities (womac) osteoarthritis index, 9-item patient health questionnaire (phq-9), sf-12 quality of life, tcm syndrome score sheet, etc. the primary outcome will be the pain (rest pain) vas, koos, womac knee osteoarthritis index score and tcm syndrome score. secondary outcomes include patient's knee joint function examination, x-ray examination results, blood routine, biochemical indicators and pharmacoeconomic data.

Eligibility criteria:
inclusion criteria: 1. the patient has repeated knee joint pain in the past month; 2. x-ray film (standing position or weight-bearing position) shows narrowing of the joint space, subchondral bone sclerosis and/or cystic degeneration, and osteophyte formation on the joint edges; 3. age ≥50 years old; 4. morning stiffness time ≤30min; 5. there is bone friction sound (sensation) during activity. patients who meet the diagnostic criteria 1 + (any 2 of 2, 3, 4, 5) can be diagnosed as koa. exclusion criteria: patients who do not meet the diagnostic criteria for knee osteoarthritis

Keywords: knee osteoarthritis
doppler and biological second trimester placental insufficiency screening

Conditions: Pre-Eclampsia; Fetal Growth Retardation; Placental Insufficiency

Summary: to assess the role of uterine artery and maternal serum leptin and lipids and their combination in screening for pre-eclampsia and small-for-gestational-age (sga) fetuses at 20-24 weeks of gestation

pre-eclampsia (pe) and intrauterine growth restriction (iugr) are known as major factors in perinatal morbidity and mortality. routine antenatal care is focused on the detection of women at increased risk to apply this population a program of careful monitoring and appropriate intervention. uterine artery doppler during anomaly scan at 20 to 24 weeks in selected women at increased risk, has proved to be accurate to detect those who will develop pe or iugr during the second half of pregnancy. studies have reported detection rate of 50-70% for a 5% false positive rate in women developing early pre-eclampsia. a variety of proteins and hormones have been studied as potential markers for pre-eclampsia. among these protein serum placental leptin has demonstrated higher levels in pregnant women who will subsequently develop pre-eclampsia. however, screening performance of leptin detection in early pregnancy has never been assessed. our study is aimed to evaluate the performance of serum leptin measurement in association with uterine artery doppler as a screening too for placental insufficiency.

Eligibility criteria:
inclusion criteria: * chronic hypertension under medication * diabetes * thrombophilia * previous history of pre-eclampsia * previous history of unexplained stillbirth * previous history of placental abruption * previous history of sga (\< 10th centile) * history of pre-eclampsia or chronic hypertension before 45 years in the mother or a sister * obesity (bmi\>30) * nulliparous after 40 years * assisted conception with donor exclusion criteria: * multiple pregnancy * complicated pregnancy with a high probability of required fetal extraction before term * pregnancy requiring termination * unability to understand the study

Keywords: screening uterine artery doppler hellp syndrome abruption
skeletal muscle and adipose tissue responses after acute exercise: comparing effects of three different intensities

Conditions: Cellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities; Relationship Between the Cellular Responses in Skeletal Muscle and the Changes in the Metabolomic Profile; Changes Within Adipose Tissue in Response to Exercise at the Three Different Intensities

Summary: the study will assess the exercise-induced changes in chromatin accessibility and gene expression in a cell type-specific manner in skeletal muscle from healthy adults in response to exercise at three different intensities - 1) low-intensity continuous exercise, 2) moderate-intensity continuous exercise, and 3) high-intensity interval exercise.


Eligibility criteria:
inclusion criteria: * age:18-40 * body mass index: 20-30 kg/m2 * must engage in regularly planned aerobic-type exercise at moderate-vigorous intensity, 3 times per week for at least 30-60 minutes/session * women must have regularly occurring menses and must be premenopausal * subject willingness to opt-in for the michigan genomics initiative (mgi) repository exclusion criteria: * evidence/history of cardiovascular or metabolic disease. * taking anti-coagulate medications or medications known to affect metabolism or inflammation * weight instability ≥ ±3kg in the last 6 months * tobacco or e-cigarette users * women must not be pregnant or actively lactating
a study of the safety and efficacy of infliximab in patients with psoriasis

Conditions: Psoriasis

Summary: the purpose of this study is to determine if infliximab (anti-tnf) is effective in the treatment of plaque psoriasis.

this is an experimental medical research study. the purpose of this study is to determine if infliximab is effective in the treatment of plaque psoriasis. a total of about 375 patients primarily in europe will participate in this study. the time of participation in this study is about 17 months. infliximab is the active drug in remicade. infliximab is currently approved for the treatment of crohn's disease (an irritable bowel disease), and rheumatoid arthritis. the usefulness and safety of infliximab in those diseases has been proven in previous research studies, which included more than 1300 patients in north america and europe. in a previous small study of infliximab in 33 patients with psoriasis, about 80% of patients treated with infliximab showed improvement in their psoriasis symptoms after the first 3 infusions, while 20% of patients who received placebo showed improvement. patients will be assigned to one of two treatment groups (group 1 and group 2). group 1 will receive 5mg/kg infliximab infusions at wks 0, 2, 4, 6, 14, 22, 30, 38 and 46 with placebo infusions at wks 24 and 26. group 2 will receive placebo infusions at wks 0, 2, 6, 10, 14, 22, with placebo infusions at wks 24, 26, 30, 38 and 46. all study medication is given though an intravenous (into the vein) line. safety evaluations will be performed at specified intervals throughout the study and will consist of laboratory tests, vital signs (such as blood pressure), physical examinations and the occurrence and severity of adverse events as well as other study specific procedures. there are 2 different treatment groups: group 1 will receive 5mg/kg infliximab infusions at wks 0, 2, 4, 6, 14, 22, 30, 38 and 46 with placebo infusions at wks 24 and 26. group 2 will receive placebo infusions at wks 0, 2, 6, 10, 14, 22, with placebo infusions at wks 24, 26, 30, 38 and 46. all study medication is given though an intravenous (into the vein) line.

Eligibility criteria:
inclusion criteria: * patients who have had a diagnosis of plaque-type psoriasis for at least 6 months * patients who have plaque-type psoriasis covering at least 10% of the body exclusion criteria: * patients must not have nonplaque forms of psoriasis * patients must not have current drug-induced psoriasis * patients must not be pregnant, nursing, or planning pregnancy (both men and women) within 18 months of enrollment * patients must not have had any previous treatment with infliximab or any therapeutic agent targeted at reducing tnf

Keywords: psoriasis infliximab remicade
novel approach for embryo transfer medium by adding cytokine to hyaluronan enriched embryo transfer medium (embryo glue)

Conditions: Infertility

Summary: it was proven that the cytokine granulocyte-macrophage clony stimulating factor had been found naturally in reproductive tract so our target is to test its effect if added to embryo transfer medium.

the ivf embryo transfer media design and upgrade underwent many ideas during the last 3 decades, we suppose that adding cytokine gm-csf as an endometrial modifier to already proven successful medium hyaluronan enriched medium to test the efficacy ipon pregnancy and implantation rate in vitro so we decide to design a trial to compare the clinical outcome by sibling embryo to be transferred into 2 groups and the same culture condition but with one arm with cytokine and the other is traditional one and closely monitor the outcome within the 2 arms and record the results.

Eligibility criteria:
inclusion criteria: * all patients exclusion criteria: * above 40 years old

Keywords: pregnancy implantation cytokine
physiological brain atlas development

Conditions: Parkinson Disease; Dystonia; Tremors; Obsessive Compulsive Disorder; Depression

Summary: enrollment of candidates undergoing a deep brain stimulator (dbs) implant.

the study proposes the enrollment of candidates undergoing a deep brain stimulator (dbs) implant. data will be collected before, during and after surgery and will be electronically entered into the atlas database where it will be stored indefinitely. the purpose of the study is to create an atlas to store physiological information utilizing non-rigid mri normalization algorithms. in addition to collating and analyzing the physiological atlas in a statistical manner that allows the surgeon to predict optimal targeting locations for dbs implants based on multiple physiological variables, including pre-operative severity of disease, intraoperative neurophysiological observations, and post-operative response to dbs stimulation therapy.

Eligibility criteria:
inclusion criteria: * any patient between the age of 7-90 * patients who have undergone deep brain stimulation (dbs) surgery as standard of care at the ohio state university exclusion criteria: * none
zoledronate in treating patients with cervical intraepithelial neoplasia 2/3 or 3

Conditions: Cervical Cancer; Precancerous Condition

Summary: rationale: chemoprevention is the use of certain drugs to keep tumors from forming, growing, or coming back. zoledronate may prevent the growth of cervical cancer by blocking blood flow to cervical intraepithelial neoplasia cells. the use of zoledronate may keep cancer from forming. purpose: this randomized is studying how well zoledronate works in treating patients with cervical intraepithelial neoplasia 2/3 or 3.

objectives: * assess clinical response, in terms of lesion size and histological grade, of oledronate in patients with cervical intraepithelial neoplasia 2/3 or 3. outline: this is a randomized, placebo-controlled, double-blind, pilot study. patients are stratified according to degree of cervical intraepithelial neoplasia (cin) (cin2/3 vs cin3). patients are randomized to 1 of 2 treatment arms. * zoledronate: 100 cc of saline with 4 mg of zoledronate intravenous (iv), over 20 minutes, for 3 doses one week apart * placebo: 100 cc of saline (iv), over 20 minutes, for 3 doses one week apart in both arms, treatment repeats every 21 days for up to 3 courses. in week 8, patients undergo surgical resection comprising loop excision or cone biopsy. after completion of study treatment, patients are followed at week 10 by telephone. projected accrual: a total of 44 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * biopsy confirmed cervical intraepithelial neoplasia (cin) 2/3 or 3 * planning loop excision or cone biopsy * diagnosis within 2 months prior to study entry * standard histological grading according to richart * visible lesion by colposcopy * no unsatisfactory colposcopy or lesions extending into the endocervical canal that cannot be visualized entirely by colposcopy * no suspicion of invasive cervical cancer by cytology, histology or colposcopy * no cytologic evidence of glandular atypia or dysplasia patient characteristics: * creatinine normal * screening laboratory values within normal range (e.g., complete blood count, liver function tests, renal panel, and electrolytes) * not pregnant or nursing * negative pregnancy test * fertile patients must use effective contraception * able to read and speak english or spanish * no known hypersensitivity to bisphosphonates * not immunocompromised * no known hiv positivity * no aspirin-sensitive asthma due to association of bisphosphonates with bronchoconstriction * no unexplained abnormal vaginal bleeding prior concurrent therapy: * no concurrent loop diuretics, aminoglycosides, other nephrotoxic drugs, immunosuppressive drugs, or other investigational agents

Keywords: cervical cancer cervical intraepithelial neoplasia grade 2 cervical intraepithelial neoplasia grade 3
single vs. double drain in modified radical mastectomy

Conditions: Breast Cancer

Summary: seroma is a common complication following modified radical mastectomy(mrm). closed drainage is used routinely to reduce incidence of seroma. usually two drains are used in patients who underwent mrm to reduce post operative seroma. it is often associated with significant patient discomfort and prolonged fluid drainage. the aim of this study is to evaluate effect of number of drains on seroma formation rate, postoperative pain and hospital stay during the immediate postoperative period after mastectomy for breast cancer.

modified radical mastectomy is commonly performed procedure for carcinoma breast. after surgery two drains are placed, one in axilla and one beneath the flap. the use of two drains is associated with significant post operative discomfort and pain. on the other hand two drains have not been proven to decrease post operative seroma formation.

Eligibility criteria:
inclusion criteria: * all female patients underwent mrm for biopsy proven carcinoma breast exclusion criteria: * immediate reconstruction * patient refusal to participate in study
hiatus hernia in old

Conditions: Hiatus Hernia

Summary: hiatus hernia in frail patient is common and requires suregry

severe frail patients had high incidence of recurrence

Eligibility criteria:
inclusion criteria: * ep aged ≥60 years for giant sliding hh with exclusion criteria: * • who required a concurrent abdominal procedure at the same time as fundoplication (e.g., cholecystectomy)(n=5) * esophageal dysmotility(n=2) * progressive systemic sclerosis (n=1)
postpartum screening for anxiety and comorbid conditions

Conditions: Postpartum Anxiety; Postpartum Depression; Postpartum Disorder; Postoperative Pain; Sleep Wake Disorders; Quality of Life; Anger

Summary: the goal of this project is to facilitate the design of individualized postpartum anxiety (ppa) screening strategies in british columbia (bc), canada. a cohort of postpartum people (n=550) will be invited to complete the following seven questionnaires at 4-8 weeks after delivery: 1. state-trait anxiety inventory 2. edinburgh postnatal depression scale 3. multidimensional scale of perceived social support 4. promis (patient-reported outcomes measurement information system) emotional distress-anger, short form 5-a 5. short form brief pain inventory 6. whoqol-bref for assessing quality of life 7. promis sleep disturbance short form 8-b and promis sleep-related impairment short form 8-a the investigators will evaluate the feasibility of screening for postpartum anxiety and comorbid conditions through a web-based platform in a diverse bc population. they will assess the usability of the platform and questionnaires through 12-15 follow-up interviews with study participants and responses to the system usability scale. their analysis will also identify patient characteristics and comorbidities (e.g., anger, pain, sleep disturbance) associated with a positive screen for postpartum anxiety.


Eligibility criteria:
inclusion criteria: * ≥ 19 years * 4-8 weeks postpartum * proficiency to participate in english * delivered within the province of british columbia, canada exclusion criteria: none.
effectiveness of osteopathy in the preoperative treatment of postoperative pain in patients undergoing total knee replacement

Conditions: Total Knee Replacement; Osteoarthritis of the Knee; Preoperative Osteopathic Care

Summary: osteopathy is an alternative healthcare that seems effective in relieving the pain of patients. the main purpose of this study is to evaluate the efficacy of preoperative osteopathic care in patients undergoing total knee arthroplasty (tka) for osteoarthritis. the secondary objectives are to assess pain during the first postoperative month on a vas and knee function and quality of life at 6 months and 1 year. our hypothesis is that osteopathy will decrease postoperative pain and increase knee function.


Eligibility criteria:
inclusion criteria: * primary total knee arthroplasty (tka) * for osteoarthritis of the knee * without surgical history on the operated knee exclusion criteria: * previous surgery on the operated knee * bilateral tka * patient refusal
the influence of inhaled adrenalin versus decongestant as a local nasal treatment in bronchiolitis

Conditions: Bronchiolitis

Summary: this was a randomized, double blinded, controlled trial. the aim of the study was to compare xylometazoline hcl nasal drops to inhalation of epinephrine as a treatment for bronchiolitis. the study hypothesis is:xylometazoline hcl nasal drops treatment is good as epinephrine inhalation for treatment of bronchiolitis. signed informed consent was obtained from a parent of each child. and the human ethics committee of our hospital approved the study according to the principles of the declaration of helsinki.(approved - 2002) patients: 65 infants who were admitted to pediatric a- a general pediatric ward, in schneider children's medical center because of bronchiolitis during winter in two consecutive years 2004-2005. the inclusion criteria were: full term previously healthy infants, ages 1-12 months, after informed consent was signed with clinical presentation of mild to moderate bronchiolitis according to a clinical score .exclusion criteria were as follows: prematurity, congenital lung or cardiac disease, infants who had past hospitalization due to respiratory illness and severe bronchiolitis (score\>7 with a range scale 0-10).

all eligible patients were randomly assigned to one of two groups: group 1 (control) received inhalation of epinephrine 1mg, in 2cc of 0.9% saline solution four times a day, and nasal drops of 0.9% saline for each nostril every twelve hours. group 2 - the study group received four inhalation of 0.9% saline four times a day and one nasal drop of xylometazoline hcl to each nostril twice a day. this treatment continued until the patient was ready for discharge. patients were examined and evaluated at the study entry and were re-evaluated every 10-12 hours. length of hospital stay,time to improve oxygen saturation, time to the need of iv fluid and clinical score between the two groups of treatment were compared.

Eligibility criteria:
inclusion criteria: * full term previously healthy infants * ages 1-12 months * after informed consent was signed with clinical presentation of mild to moderate bronchiolitis exclusion criteria: * prematurity, congenital lung or cardiac disease * infants who had past hospitalization due to respiratory illness and severe bronchiolitis (score \>7 with a range scale 0-10)

Keywords: epinephrine nasal decongestant rsv xylometazoline bronchiolitis
high energy density pulse electromagnetic field for patients with rotator cuff tendinopathy

Conditions: Rotator Cuff Tendinosis

Summary: the aim of our study is to investigate the efficacy of high energy density pulse electromagnetic field for patients with rotator cuff tendinopathy

traditional pulse electromagnetic field (pemf) devices have been approved by the u.s. food and drug administration (fda) to treat nonunion fractures and cleared to treat post-operative pain and edema, osteoarthritis, and plantar fasciitis. however, high level of evidence indicated that the lack of beneficial effects of pemf on pain, function or range of motion in the treatment of shoulder pain. high energy density pulse electromagnetic field(high-pemf) which builds up a voltage up to 30 kilovolt (kv) with shorter impulse time(50us) and broad band-width(200khz\~300mhz) is very different from traditional pemf. magnetic field about 50\~150 millitesla (mt) is created and it can penetrate the body up to 20 cm. the aim of our study is to investigate the efficacy of high-pemf for patients with rotator cuff tendinopathy.

Eligibility criteria:
inclusion criteria: 1. age between 20 to 75 years old 2. persistent shoulder pain for at least 3 months and pain vas score \>=5 3. positive result in any of the following physical examinations: hawkins-kennedy, neer or jobe tests 4. confirmed rotator cuff tendinopathy by ultrasonography or mri exclusion criteria: 1. complete or full-thickness tear of rotator cuff found by ultrasonography or mri 2. previous shoulder surgery 3. previous history of severe trauma in shoulder 4. cervical radiculopathy related shoulder pain or referred pain 5. other shoulder diseases: adhesive capsulitis, calcifying tendinopathy, radiology-confirmed acromion type iii, shoulder instability, degenerative osteoarthritis, labral tear 6. present with any of the following systemic diseases: active infection, sever and uncontrolled medical condition, cancer, immune-related or rheumatoid arthritis, hyperuricemia and gout 7. previous treatment with articular or subacromial steroid injections within the last 3 months 8. cognitive impairment with loss of ability to sign the agreement and receive rehabilitation 9. pregnancy or lactating women 10. has any of the following contraindications: carriers of pacemakers, internal defibrillators,internal metal implants (locally dependent), cochlea implants, metallic stents, insulin pumps

Keywords: rotator cuff tendinopathy high energy density pulse electromagnetic field