effects of whole body vibration training in patients with interstitial lung disease

Conditions: Interstitial Lung Disease; Scleroderma; Idiopathic Pulmonary Fibrosis

Summary: interstitial lung disease (ild) is a diverse group of parenchymal lung disorders characterized by restrictive lung function and impaired alveolar diffusion capacity, leading to dyspnea on exertion, reduced exercise endurance, and poor quality of life. patients usually complain of progressive breathlessness, persisting non-productive cough, which occurs with exercise. hemoptysis, fever, chest pain are also seen. the most common comorbidity in chronic lung diseases is the progressive loss of exercise tolerance. not only dyspnea, but also peripheral muscle dysfunction and cognitive deficits such as, anxiety and depression are responsible for the reduction of mobility in the patient. in the context of pulmonary rehabilitation (pr) program to be applied in interstitial lung diseases; upper and lower limb endurance, stretching and relaxation techniques, aerobic exercise training, respiratory muscle training, training of energy conservation methods, support by determining oxygen requirement, nutritional evaluation, prevention of weight and muscle loss, psycho-social support. the purpose of pr programs in this disease is; to improve muscle strength, endurance, and mechanical activity, to improve dyspnea sensation, to improve functional capacity, to inform and educate the patient about the patient's disease. the use of whole body vibration (tvt) is an increasingly common method of therapeutic use in order to improve neuromuscular performance. tvt applications have shown that increases muscle activity, muscle strength and muscle strength, improves lower extremity blood circulation and balance, and increases growth hormone production. tvt training effects have rarely been studied in patients with pulmonary disease. muscle strength and performance enhancement were significant effects of tvt, which was emphasized as a promising exercise method for those with chronic obstructive pulmonary disease (copd). over the past decade, endurance and strength training has been established as the most important components of exercise training programs in patients with copd and ild. therefore, inclusion of tvt into exercise training programs in ild patients may lead to beneficial results. the investigators hypotheses are: 1. the combination of home respiratory exercises with whole body vibration training may lead to more improved respiratory muscle strength, dyspnoea, functional capacity, balance, peripheral muscle strength and quality of life in ild patients 2. when applied as an isolated intervention, home respiratory exercises programme may lead to lower results than combination programs.

patients: all participants with ild will be recruited from a cerrahpasa medical faculty hospital between january 2017 and june 2018. all treatments will performed in the same hospital. sample size: "power and sample size program" was used to calculate sample size. power analysis was done with pass 11 home program. in the power analysis program, α = 0,05, β = 0,15 1- β = 0,84. when the number of samples of the groups was 30 and 30, 84% power was obtained. using a two-sided two-sample t-test, the standard deviations from the 0,05 alpha value are 7.0 and 6.0. procedure: a list of individuals diagnosed with interstitial lung disease who are following the outpatient clinic of the department of chest diseases of the istanbul university cerrahpaşa medical faculty and who meet the inclusion criteria for the study will be created. the created patient list will be enumerated. two groups will be formed from the numbered persons by the random number table method (n = 60). groups will receive 30 participants in the treatment group, whose protocol numbers end in an even number, and 30 members in the control group, who finished with an odd number of protocol numbers. up to 10% of the sample size will be selected as a substitute, taking into account the non-participation of the selected individuals in the study. assessments at baseline and after training will be performed by pulmonary physiotherapist. all the participants will be treated in the cerrahpaşa medical faculty hospital by a physiotherapist who is experienced in pulmonary rehabilitation.

Eligibility criteria:
inclusion criteria: * patients with interstitial lung disease (idiopathic pulmonary fibrosis, pneumoconiosis, chronic hypersensitivity pneumonia, radiation fibrosis, collagenosis pulmonary involvement, nonspecific interstitial pneumonitis-nsip, idiopathic nsip) * patients whose stability and medical treatment have not been changed for the last 3 months will be included in the study. exclusion criteria: * malignant tumor, * presence of co-morbidities that prevent exercise training (severe orthopedic or neurological deficit, unstable cardiac disease) * the knee and / or hip joint replacement operation has been performed, * having lower and upper limb amputation, * taking any hormone replacement or medication that may affect the normal metabolism of the musculoskeletal system, * presence of neurological (ms, intracranial tumor, neurodegenerative diseases, cerebrovascular event, epilepsy) disease which will affect balance and proprioception, * those with drug use history (antidepressants, anticonvulsants, sedatives, betahistine) that may affect the balance, * having ischemic heart disease, dilate, hypertrophic or nonidiopathic cardiomyopathy, * having pacemaker entity, by-pass, coronary stent, * having uncontrolled dm, * presence of acute arthritis / tendinopathy, * o2 saturation in room air \<80% (resting), patient with advanced respiratory failure, * having severe neurological and / or metabolic pathologies, * having hemodynamic instability, * being pregnant and breastfeeding, * individuals with a recent surgical operation, ild, will not be included in the study.

Keywords: pulmonary function test peripheral muscle strength postural balance dyspnea pulmonary muscle strength functional capacity fatigue quality of life