Kornimate/medical-research-clean huggingface dataset:
evaluation of stereotactic radiosurgery for liver malignancies

Conditions: Cholangiocarcinoma; Liver Cancer; Adenocarcinoma

Summary: this study is intended to establish the practicality of treating cancer in the liver with precisely administered single fractions of high-energy radiation using a radiosurgical (cross-firing) technique. a second purpose is to establish a safe dose for such therapy. finally, the efficacy of radiosurgical ablation of liver tumors, in terms of radiographic response, will be measured.


Eligibility criteria:
inclusion criteria:all the following criteria must be met: * liver tumors not to exceed 5 cm in diameter. if this size can be increased at all, that would be beneficial as many liver lesions present at a larger size given the lack of symptoms until they are larger and adequate hepatic function with albumin \>3.0, total bilirubin \<3, inr 1.8. in the case of patients with known or 7 dose escalation study evaluating stereotactic radiosurgery for liver malignancies suspected cirrhosis, patients must have creatinine \<1.5 and cannot have uncontrolled ascites, encephalopathy, active or recent gastrointestinal bleed (gib). * age \> 18 years old * histologically confirmed hepatocellular carcinoma (hcc), intrahepatic cholangiocarcinoma (ihcc), or metastatic adenocarcinoma of the breast/colon. metastatic tumors of other histologic types or sites of origin may be included if the patients have a life expectancy of 6 months or greater. in the case of suspected hcc in patients with known cirrhosis, noninvasive criteria recommended by the european association for the study of liver diseases may be used. hypervascular lesions \> 2cm with alpha-fetoprotein (afp) \> 400ng/ml or hypervascular lesions \>2cm on at least 2 imaging studies. * unresectable disease as determined by a surgeon * eastern clinical oncology group performance status 0,1 or 2 * no chemotherapy within 1 month of registration * no prior radiotherapy to the liver or upper abdominal area * life expectancy \> 6 months * patients with ihcc or hcc with distant metastasis are not eligible for this study. * for colon cancer patients with metastatic tumor of the liver who are not amenable to surgical resection due to the efficacy of removal of simultaneous lung and liver metastasis. exclusion criteria:- children are excluded because hcc, ihcc, and hepatic metastases rarely occur in this age group. furthermore, treatment requires a great deal of patient cooperation including the ability to lie still for several hours in an isolated room. * no laboratory personnel will be included.
aldoa expression in bladder urothelial carcinoma

Conditions: Bladder Urothelial Carcinoma

Summary: 1. study the immunohistochemical expression of aldoa in bladder urothelial cancer. 2. correlate between aldoa expression in specimens and different cilnicopathological factors. 3. correlate between aldoa expression and urothelial cancer prognosis and survival.

bladder cancer is the 7th most prevalent malignancy and the 13th cause of cancer related death worldwide1. in egypt, it's the third most common tumor2. the most common histologic subtype of bladder cancer is urothelial carcinoma3. bladder cancer is divided according to absence or presence of muscle invasion into non-muscle invasive bladder cancer and muscle invasive bladder cancer 3. despite the advance in diagnosis and development of therapeutic options of urothelial cancer, the recurrence and progression rate remains high4. the conventional histopathological evaluation of urothelial cancer is vital for diagnosis and prediction of patient's prognosis. however, it doesn't fully reflect the biological behavior of the tumor or the clinical outcome of the patient5. under hypoxic conditions, cancer cells produce atp by glycolysis, which provide energy for tumor proliferation and dissemination6,7. glycolytic enzymes are abnormally activated in cancer cells8,9. thus, several studies have identified glycolytic enzymes or related metabolic pathways as potential drug targets. one of the typical glycolytic enzymes is aldolase a (aldoa) 6 which is the most abundant glycolytic enzyme detected in tumors10. several studies have identified aldoa as an oncogene in different types of malignancy 6,8,10-12. the oncogenic potential of aldoa contributed to its ability to stimulate dna synthesis and accelerate s phase in tumor cell cycle6-8. in addition, studies have shown that aldoa promotes tumor cell invasion by negative regulation of e-cadherin and by activation of mapk, akt and egfr signaling pathways7,11,13. thus, increased expression of aldoa in tumor predicts a bad prognosis and poor survival of patients13-15.

Eligibility criteria:
inclusion criteria: * all cases diagnosed as bladder urothelial cancer with known follow-up data and presence of muscle proper detected in the specimens. exclusion criteria: 1. subtypes of bladder cancer other than urothelial carcinoma subtype. 2. cases of urothelial carcinoma without known follow up data. 3. cases of urothelial carcinoma without muscle proper detected in the specimen.
picu-related sleep and circadian dysregulation pilot study

Conditions: Circadian Dysrhythmia; Sleep Disturbance; Critical Illness; Children, Only

Summary: a single center pilot trial investigating the feasibility of using actigraphy and salivary melatonin levels to measure the sleep and circadian rhythm of critically ill children aged 3 to 6 years old. this study will also measure the feasibility of providing daytime light exposure as well as restricting all provided nutrition to during daytime hours.

several of the identified sleep disruptors in a pediatric intensive care environment may not be modifiable, including restricting feeding to daytime hours and providing normal daytime light exposure. this study aims to measure the feasibility of measuring sleep and circadian patterns in a picu during routine care and during 2 focused sleep promotion interventions: timed daytime light exposure (dle) and daytime feeding restriction (dfr). the overall objective of this study is to test the hypothesis that, with multi-disciplinary efforts, providing chronotherapeutic care will be feasible and that reliably measuring sleep patterns and the cr of critically ill children with timed salivary melatonin assays and actigraphy is possible.

Eligibility criteria:
inclusion criteria: 1. child age 3 to 6 years old on the day of picu admission 2. english-speaking parent at the bedside 3. child expected to remain in the picu over 24 to 48 hours exclusion criteria: 1. child is in end-of-life care 2. the child is receiving neuromuscular blockade for any reason 3. caregiver or parent not at the bedside

Keywords: sleep disruption circadian rhythm critical care pediatrics
a study of cm310 in patients with uncontrolled seasonal allergic rhinitis

Conditions: Allergic Rhinitis

Summary: allergic rhinitis (ar) is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by immunoglobulin e after exposure to allergens in atopic individuals. the typical symptoms of ar are paroxysmal sneezing, watery rhinorrhea, itching, and nasal congestion, which may be accompanied by ocular symptoms, including eye itching, tearing, redness, and burning sensation, which are more common in patients with hay fever allergies. bronchial asthma is associated with bronchial asthma in 40% of patients with ar, suggesting a comorbid feature of allergic disease.

ar is a common clinical chronic nasal disease, affecting 10% to 20% of the world's population, and has become a global health problem. ar not only seriously affects the quality of life of patients, resulting in patient fatigue, impaired learning, attention, and decision-making ability, but also causes a heavy social burden. ar has a variety of classification methods. according to the type of allergen, it can be divided into seasonal (sar, common allergens are seasonal allergens such as pollen) and perennial (par, common allergens are indoor allergens such as dust mites or occupational allergies), which is a classification method often used in clinical studies. according to the course of the disease, it can be divided into intermittent (symptom onset \< 4 days/week, or \< 4 consecutive weeks) and persistent (symptom onset ≥ 4 days/week, and ≥ 4 consecutive weeks). according to the severity of the disease, it can be divided into minor ar (mild symptoms, with no significant impact on quality of life) and moderate-severe ar (more severe or severe symptoms, with significant impact on quality of life). the results of the cooperative survey showed that persistent moderate-to-severe disease was the most common in the overall population, accounting for 52.2%, indicating that the treatment and control of ar has become an urgent problem to be solved.

Eligibility criteria:
inclusion criteria: * voluntarily sign the informed consent form. exclusion criteria: * have any condition that are not suitable for participating in this study.
strategy training for individuals with unilateral neglect

Conditions: Stroke; Neglect, Hemispatial

Summary: it is common for individuals after stroke to have a cognitive perceptual impairment called unilateral spatial neglect (neglect). individuals with neglect have difficulty paying attention to one side of their body or one side of the environment and therefore experience difficulty performing daily activities. there are a lack of effective treatments for neglect and new interventions are needed to help reduce disability for these individuals. metacognitive strategy training (strategy training) is an intervention that has the potential to reduce neglect-related disability and improve individuals' awareness of their neglect. this study seeks to examine the effects of strategy training on self-awareness, disability, and neglect.

unilateral spatial neglect (neglect) post stroke is characterized by a lack of attention to one side of the body or one side of the environment. individuals with neglect experience significant disability and are often unaware of their neglect symptoms which can make it even more difficult to treat. there are a lack of effective treatments for neglect and new interventions are needed to help reduce disability for these individuals. metacognitive strategy training (strategy training) is an intervention that has the potential to reduce neglect-related disability and improve individuals' awareness of their neglect. strategy training teaches individuals to develop personalized goals, self-assess their performance of daily activities, and develop and evaluate strategies designed to overcome barriers and improve their performance of daily activities. while strategy training shows promise for individuals with neglect, no studies have tailored the intervention for this group of individuals or examined the effects of strategy training for individuals with neglect. this study examines whether strategy training facilitates reductions in disability and neglect and improves self-awareness after acute stroke.

Eligibility criteria:
inclusion criteria: * primary diagnosis of stroke * admission to inpatient rehabilitation facility * ≥18 years old * presence of neglect as determined by score of \<18 on the virtual reality lateralized attention test (vrlat) or score below established cutoff for neglect on one of the six subtests of the behavioral inattention test (bit) exclusion criteria: * boston diagnostic aphasia examination (bdae) severity scale score of 0 (severe global aphasia) * diagnosis of dementia indicated in medical record * diagnosis of active major depressive disorder/bipolar/psychotic disorder indicated in medical record * anticipated length of stay \<10 days
characterization of non-canonical way in inflammasome monocytes of patients with severe sepsis

Conditions: Severe Sepsis

Summary: activation of caspase-4 and human caspase-5 (orthologs of caspase-11 in mice) in innate immune cells.

lipopolysaccharide (lps) of the wall of gram-negative bacteria is one of pathogen associated molecular patterns (pamps), which are recognized by cells of the innate immune system via toll-like receptor 4 (tlr4) . the lps / tlr4 interaction induces the secretion of a variety of proinflammatory cytokines. among them, interleukin-1β (il-1β) is a major cytokine, and alterations to its secretion has been associated with various diseases, such as periodic syndrome associated cryopyrin (caps), gout, rheumatoid arthritis or multiple sclerosis. the release of il-1β is controlled by a molecular platform protein, known as the inflammasome name. the canonical protein (that is to say conserved in evolution) of the inflammasome nlrp3 are nlrc4 and that engages the asc adapter protein to activate caspase-1, which promotes the cleavage of interleukin il-1β. gram-negative bacteria such as escherichia coli cause non-canonical activation of caspase-1, caspase-11in involving more nlrp3 and auc. in mouse, caspase-11 is essential to the immune response to gram-negative bacteria, but bacterial pamps that are responsible for triggering of the non-canonical inflammasome remain to be identified. it has recently been shown that caspase-11 is involved in the death of the mice subjected to septic shock. the mouse model requires caspase-11-dependent mechanism, caspase-independent -1 since the casp1 - / - mouses are also susceptible to lps as wild type mice. a key question to be answered is whether lps triggers similar events in human cells. if this is the case, this knowledge may be useful in drug development for treatment of sepsis.

Eligibility criteria:
inclusion criteria: * patients with sepsis severe (bacterial infection associated with deterioration of at least one vital function) defined according to the criteria consensus conference * patients whose diagnosis is made within 24 hours of the opening hours of pasteur research laboratory * patients with arterial catheter (not to impose an additional puncture to the patient) will be recruited in the intensive care unit of the hospital st. joseph. arterial blood (20 ml) will be charged within 24 hours of the onset of severe sepsis criteria, during working hours of the laboratory of the pasteur institute, using vacuum tubes under heparin (vacutainer), sent by a courier within 2 hours following the removal (to ensure that the cells are sufficiently "fresh" during processing in the laboratory) exclusion criteria: * none

Keywords: lipopolysaccharide sepsis caspase-4 and -5 monocytes il-1β and il-1α
an investigational study to evaluate the safety and effectiveness of bms-986165 with background treatment in participants with lupus nephritis

Conditions: Lupus Nephritis

Summary: the purpose of this study is to evaluate the safety and effectiveness of bms-986165 compared with placebo with regard to measures of kidney function in participants with lupus nephritis (ln).


Eligibility criteria:
for more information regarding bristol-myers squibb clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * meets the systemic lupus erythematosus international collaborating clinics (slicc) criteria for systemic lupus erythematosus (sle) * renal biopsy confirming a histologic diagnosis of active lupus nephritis (ln) international scociety of nephrology/renal pathology society (isn/rps) classes iii, iv-s, or iv-g; or class v * urine protein:creatinine ratio (upcr) ≥1.5 mg/mg or upcr ≥1 mg/mg assessed with a 24-hour urine specimen exclusion criteria: * pure isn/rps class v membranous ln * screening estimated glomerular filtration rate ≤30 ml/min/1.73 m\^2 * dialysis within 12 months before screening or plans for dialysis within 6 months after enrollment in the study * end-stage renal disease other protocol-defined inclusion/exclusion criteria apply
effects of covid-19 infection on pregnancy outcomes and offspring health

Conditions: COVID-19

Summary: this is a large observational cohort study to assess the impact of covid-19 infection on pregnancy outcomes and offspring health.

the influence of sars-cov-2 infection on reproductive outcomes has been uncertain. the goal of this observational study is to assess the impact of covid-19 infection on pregnancy outcomes and offspring health for patients with childbearing needs. participants will: 1. undergo a questionnaire to gather details on covid-19 infection history. 2. provide data about reproductive history. 3. be invited for physical examination, laboratory tests and ultrasound scans. 4. undergo a long-term follow up for pregnancy outcome and offspring health.

Eligibility criteria:
inclusion criteria: 1. women aged between 18-50 years old. 2. patients with signed informed consent. 3. patients with complete covid-19 infection information. exclusion criteria: 1. patients with abnormal karyotype 2. recipients of oocyte donation.
vaccination impact against pneumococcal disease on acute otitis media morbidity in colombian children < 5 years of age

Conditions: Acute Otitis Media; Pneumonia

Summary: the purpose of this study is to provide data on trends of morbidity due to acute otitis media (aom) (primary analysis) and morbidity and mortality due to pneumonia, and aom related health care resources before and after the introduction of vaccination against pneumococcal disease within the universal mass vaccination (umv) in colombia.


Eligibility criteria:
inclusion criteria: * children aged less than five years with record of acute otitis media (with icd-10 codes: h65 to h66) and/or. * children aged less than five years with record of pneumonia (with icd-10 codes: j13 to j18) and/or. * children aged less than five years with any icd-10 codes for respiratory diseases (j00-j99). exclusion criteria: • not applicable

Keywords: colombia otitis database pneumonia
study comparing conventional and fast track multi-discipline treatment interventions for colorectal cancer

Conditions: Length of Stay; Complications; Adverse Drug Event; Quality of Life; Hospital Costs

Summary: a new notion"fast track multi-discipline treatment" for colorectal cancer is thought with several benefits such as shorter hospitalization stay and less costs. this randomized study aims to compare the differences between conventional and fast track multi-discipline treatment for colorectal cancer in hospitalization day, complications, costs and quality of life.

laparoscopic surgery, fast track treatment and xelox chemotherapy have been introduced in the treatment of colorectal cancer. all of these procedures are contributed to reduce the hospitalization stay. however, the most economical mode for combination of these procedures is still unclear. this is a randomized controlled study, a new notion"fast track multi-discipline treatment" is proposed, which is the combination of the laparoscopic surgery, fast track perioperative treatment during perioperative period and xelox chemotherapy. the purpose of this study is to compare the fast track multi-discipline treatment with the conventional treatment(open surgery with conventional treatment during perioperative period and mfolfox6 chemotherapy) for colorectal cancer on several aspects like the average hospitalization day, complications, costs and quality of life.the focus of the study will be to investigate whether the fast track multi-discipline treatment reduces hospital stay with similar complications compared with conventional perioperative treatment. moreover, the trial will clarify whether laparoscopic surgery is essential for fast track multi-discipline treatment.

Eligibility criteria:
inclusion criteria: 1. patients with pathologically confirmed colorectal cancer 2. signed consent exclusion criteria: 1. tumor can be resected by endoscopic mucosal resection(emr) 2. history of malignancy 3. bowel obstruction or intestinal perforation 4. evidence of metastasis by physical examination, chest roentgenogram and computed tomography of liver and pelvis 5. acute diseases and acute attack of chronic diseases 6. psychiatric history 7. deformity of spine 8. asa score≥ⅳ 9. mid-low rectal cancer 10. pregnant woman 11. needing to use chinese traditional patent drug
evaluation of renal oxygenation by nirs in pediatric endourologic stone surgery

Conditions: Renal Stone; Kidney; Complications; Ureter Stone; Renal Oxygenation

Summary: the study aims to compare renal oxygenation levels in retrograde intrarenal surgery (rirs) and ureteroscopy (urs) procedures with a control group. additionally, it seeks to determine if there is a connection between postoperative infection parameters and intraoperative renal oxygenation measurements.

the study will involve asa class i-iii pediatric patients aged 1-18 undergoing rirs, urs, and hypospadias surgery under general anesthesia. patients will be divided into three groups: group r (rirs), group u (urs), and group h (hypospadias/control). data collection will include patient height and weight. in groups r and u, pre- and postoperative measurements such as hemoglobin, hematocrit, leukocyte count, bun, serum creatinine, procalcitonin, interleukin-6, and crp values will be recorded. all three groups will undergo nirs monitoring alongside routine asa monitoring. renal nirs probes will be positioned using ultrasonography, and the average of three measurements will determine the regional oxygen saturation index (rso2) as the initial value. nirs, pulse oximetry, and hemodynamic data will be recorded every 5 minutes until recovery from anesthesia just prior to induction. a decrease of 20% or more than 20% when comparing nirs values during follow-up with the baseline will be considered significant. the study will also document anesthesia and surgery times, as well as postoperative fever and the amount of irrigation fluid used in groups r and u.

Eligibility criteria:
inclusion criteria: * 1-18 years asa i-iii class, * patients who will undergo rirs, urs and hypospadias surgeries under standard general anesthesia. * patients whose informed consent form is approved by their parents will be included in the study. exclusion criteria: * exclusio criteria were the history of renal failure, renal tumors, infection of the perirenal region; receiving colloid or blood transfusion, having abscess, body mass index (bmi) not in the normal limits (≤3% or ≥97%) * patients whose parents do not approve the informed consent form will not be included in the study.

Keywords: near infrared spectroscopy pediatric renal oxygenation endourologic stone surgery infectious complication