Kornimate/medical-research-clean huggingface dataset:
predicting responsiveness in oncology patients based on host response evaluation during anti cancer treatments

Conditions: Stage IV Non-small Cell Lung Cancer; Stage IV Malignant Melanoma; Stage IV Small Cell Lung Cancer; Stage III Malignant Melanoma

Summary: this study will develop an algorithm of identifying patients with stage iv nsclc and melanoma who could benefit from cancer treatment they receive.

the goal of this research study is to develop an algorithm that predicts the patient's treatment outcome.this algorithm will serve as a tool for physicians when making treatment decisions, specifically for stage iv nsclc and malignant melanoma patients receiving anti-cancer treatments. the investigators also aim to identify the metabolic pathways that could lead to better therapeutic options. the patients will be given their treatment according to the institute's standard of care. the patients will provide two blood samples and clinical data will be collected from their medical records. in the first part of the trial, the data obtained from the blood samples and the medical records of the patients will be used to develop the prediction algorithm, and in the second part of the trial, the algorithm will be validated by comparing the objective response rate of the patients to the theoretical response prediction of the algorithm.

Eligibility criteria:
inclusion criteria: * cancer patients with stage iv nsclc or stage iv malignant melanoma * patient must have at least one measurable lesion and the relevant images in order to enable assessment of response * ecog ps - 0/1-2 * normal hematologic, renal and liver function: 1. absolute neutrophil count higher than 1500/mm3 2. platelets count higher than 100,000/mm3 3. haemoglobin higher than 9 g/dl 4. creatinine concentration ≤1.4 mg/dl, or creatinine clearance higher than 40 ml/min 5. total bilirubin lower than 1.5 mg/dl, alt and ast levels ≤ 3 times above the upper normal limit. exclusion criteria: * concurrent and/or other active malignancy that has required systemic treatment within 2 years of first dose of study drug * generalized impairment or mental incompetence that would render the patient unable to understand his/her participation in the study.
mr quality + diagnostic performance for chc diagnosis - gadoxetic acid, gadoteric acid and p03277 comparison

Conditions: Hepatocellular Carcinoma

Summary: compare diagnostic mri performance of gadoteric acid, gadoxetic acid and p03277 for suspected chc nodules less than 3 cm, using lirads criteria


Eligibility criteria:
inclusion criteria: * patients who had all three mri scans as part of the diagnosis of the same suspected chc lesion(s) * reference diagnosis obtained for suspected chc nodules by a diagnostic algorithm taking into account histology, imaging and follow-up exclusion criteria: * delay between first mri and 3rd mri greater than 3 months
modifiable predictors of neural vulnerabilities for obesity

Conditions: Obesity

Summary: the purpose of this study is to examine how certain factors in childhood and adolescence relate to neural vulnerabilities for obesity in young adulthood. it is hypothesized that specific individual and environmental factors will significantly predict neural vulnerabilities for obesity.

studies aimed at elucidating neural vulnerability factors for obesity - including high food reward sensitivity and poor food regulation - hold particular promise. however, relatively little is known about the modifiable factors that contribute to these neural vulnerabilities, thus precluding the development of potentially powerful interventions to promote healthy long-term weight trajectories. further, the limited research in this area lacks critical developmental and environmental context. the current proposal addresses these gaps by examining the roles of selected modifiable cognitive (executive control), behavioral (diet, sleep), affective (negative affect), and environmental (obesogenic environment) factors throughout childhood and adolescence in predicting emerging neural vulnerabilities for obesity during the pivotal transition to young adulthood. the specific aims are to: 1) determine the impact of executive control development across childhood and adolescence on food reward sensitivity and regulation in young adulthood; 2) determine the impact of a set of behavioral and affective factors in adolescence (i.e., diet, sleep, negative affect) on food reward sensitivity and regulation in young adulthood; and 3) explore the impact of the obesogenic environment encountered in adolescence on food reward sensitivity and regulation in young adulthood.

Eligibility criteria:
inclusion criteria: * age 19 years or older * previous participation in the preschool problem solving study or lived in lancaster county, ne for at least part of high school exclusion criteria: * contraindications for functional magnetic resonance imaging (fmri): * metal in body * pregnancy * braces * non-removal piercings * hair extensions * as of 8/13/21, for individuals who were not in the preschool problem solving study but are invited to participate in the current study because they lived in lancaster county for at least part of high school, the maximum age for eligibility is 20 years of age.
the effect of ketogenic diet on malignant tumors- recurrence and progress

Conditions: Malignant Tumors

Summary: the aim of the study is, to study the efficacy of the ketogenic diet in delaying or preventing recurrence and tumor growth progression of patients who have been previously treated by concomitant chemoradiotherapy (6 months) for high-grade glial tumors. it will be an open-label trial of nutritional intervention for up to 1 year. an interim analysis of the data will be carried out to assess safety, compliance and efficacy of the diet. this will be reviewed by both shs and the clinical trial team.


Eligibility criteria:
inclusion criteria: 1. consenting adults aged ≥ 18 years. 2. recurrent or progressive high grade glioma after failure of at least one line of standard oncological treatment. 3. gliomatosis cerebri, including patients declining radiation treatment. exclusion criteria: 1. patients with malignant tumors who are receiving treatment at the time of the recruitment. 2. early termination - patients who will wish to stop their participation in the trial will discontinue the ketogenic diet and return to their usual diet.

Keywords: patients with malignant tumors
tmc125-tidp35-c213: safety and antiviral activity of etravirine (tmc125) in treatment-experienced, hiv infected children and adolescents

Conditions: HIV-1

Summary: the purpose of this study is to determine the safety and antiviral activity of etravirine in treatment-experienced human immunodeficiency virus (hiv) infected children and adolescents.

the study design is a single arm treatment (all patients assigned to receive etravirine), open label (patients will know the identity of the treatments they are receiving) safety and antiviral activity of etravirine (tmc125) in treatment-experienced, hiv infected children and adolescents 6 to 17 years of age. etravirine is a new drug belonging to the nnrti (a non-nucleoside reverse transcriptase inhibitor) drug class that slows down the growth of the human immunodeficiency virus (hiv). this drug has been tested for safety and effectiveness in adults, however, there is no data on the drug's long-term safety and antiviral activity in children and adolescents. this study will last for a maximum of 48 weeks. a total of 100 ptients will receive etravirine tablets based on body weight and an investigator selected optimized background regimen (obr) of at least 2 antiretrovirals (arvs), consisting of a boosted protease inhibitor (pi) and nucleoside reverse transcriptase inhibitor(s) (nrti\[s\]). use of enfuvirtide is optional. safety will be monitored throughout the study.

Eligibility criteria:
inclusion criteria: * hiv-1 infected * body weight according to age within the 10-90th percentile of cdc growth chart * on steady antiretroviral therapy regimen for at least 8 weeks at screening and willing to remain on that regimen until baseline * hiv viral load of 1,000 copies/ml or greater at study entry * parent or legal guardian willing to provide informed consent, if necessary exclusion criteria: * the key exclusion criteria are: evidence of resistance to etravirinel any grade 3 or 4 toxicity (more information available in the protocol) * use of disallowed concomitant therapy (specified in the protocol) * currently active aids defining illness (category c) * active hepatitis a, b or c virus infection * any clinically significant diseases or findings that, in the opinion of the investigator, would interfere with the study * receipt of any arv or non-arv investigational medication or investigational vaccine within 30 days prior to screening * history of clinically significant allergy or hypersensitivity to any of the excipients of the investigational medication (tmc125)

Keywords: hiv-1 tmc125-tidp35-c213 tmc125-c213
multimodal oral analgesia for trauma in the emergency department

Conditions: Pain

Summary: the prevalence of pain in the emergency department is estimated between 60% and 78%. however, many studies reported oligo analgesia in about half of patient admitted to the emergency department. the delay before effective analgesia is one of the main causes of oligoanalgesia. the use of nurse-directed protocol allows the administration of analgesic upon admission to the emergency department. nevertheless the need of intravenous access may delay analgesia. the use of oral form analgesics even with immediate release does not allow effective analgesia before 20 min. pain management protocol in the emergency reception desk of chu grenoble alpes (chuga) includes paracetamol that can be combined with oxycodone tablets depending on the pain intensity. for any mono traumatized it is possible to associate self-administer methoxyflurane inhaler. the pain management protocol is already used in the emergency reception desk of chu grenoble alpes.the different analgesics( paracetamol,oral oxycodone, methoxyflurane) are already administered as part of routine care.the use of these different analgesics means would allow a rapid and adapted effectiveness to the pain intensity. however, there are no data on the efficacy and acceptability of such an early multimodal analgesia protocol in the emergency department.

200 patients will be included from 8:00 am to 8:00 pm and will receive a multimodal analgesia under the nurse-directed pain management protocol (paracetamol +/- oral oxycodone +/- methoxyflurane) as part of routine medical care. the pain will be evaluated (numerical rating scale) prior to the administration and reassessed by a nurse every 5 minutes for 30 minutes and then at 45min and 1 hour after administration of the pain protocol. satisfaction of patients and caregivers will also be assessed at the end of care.

Eligibility criteria:
inclusion criteria: * adult patients : ≥ 18 year and older * trauma pain * nrs≥ 4 * non- opposition to participate in the study exclusion criteria: * trauma with at least one of the following severity criteria: * suspected (from mechanism) or confirmed multiple trauma * state of shock * suspected or proven trauma to the thorax (excluding isolated rib fractures with spo2 ≥ 98%) * suspected or proven abdominal trauma * suspected or proven pelvic trauma * severe traumatic brain injury * altered level of consciousness (glasgow score \< 15) * patients who took any analgesic within 4 hours prior to admission (except paracetamol) * use of nitrous oxide in the hour before admission * patient requiring an intravenous access at admission (e.g. : open fracture displaced) * hypersensitivity to one of the molecules of the analgesia protocol * known pregnant or likely to be pregnant women at the time of inclusion * subject in an exclusion period from another study * subjects under tutelage or subjects deprived of liberty * patients to be unable to understand the purpose of study

Keywords: emergency, trauma pain, analgesia, methoxyfurane
treatments for improving mood in depressed teens-2

Conditions: Depression

Summary: phase 2: open trial n=12 adolescents will be enrolled into a single-arm pilot trial to test the adapted hatha yoga intervention

in phase 2, the investigators will conduct an open single-arm pilot trial of our 12 week adapted hatha yoga intervention. the investigators will enroll 12 adolescents in the open pilot trial.

Eligibility criteria:
inclusion criteria: 1. adolescents must have elevated depressive symptoms, defined by a score of 11 or higher on the quick inventory of depression -adolescent version-- clinician rating (qids-a-cr), including endorsement of either sad mood or anhedonia on the qids. 2. other treatment for depression must be stable at baseline. adolescents do not have to be in other treatment for depression, but, if they are, it must be stable for the past 12 weeks. 3. adolescents must be aged 13-18. 4. adolescents must be medically cleared for moderate physical activity by their primary care physician. this criterion may be met by a current (dated in the past year) statement from their pediatrician that the adolescent may participate in school or camp programs including physical education. 5. adolescents must be able to read and write english sufficient to complete informed consent and engage in interventions. 6. adolescents aged 13-17 must assent to be in the study, and their parent or legal guardian must consent to their participation. adolescents aged 18 must consent to be in the study. 7. able to attend one of the class times. exclusion criteria: 1. qids- a-cr may not be higher than a score of 21. this ensures that adolescents are not severely depressed. 2. adolescents who meet criteria for: * current (past year) autism spectrum disorder (as), if of sufficient severity to interfere with study treatment per clinician judgment; * schizophrenia; * bipolar disorder; * clinically significant psychotic symptoms in the past month; * anorexia or bulimia in past 3 months * substance use disorders in the past 12 months and symptoms are of sufficient severity to interfere with study treatment per clinician judgment these will be assessed with the mini-international neuropsychiatric interview (mini). 3. adolescents may not have current suicide ideation or behavior that warrants immediate treatment. they may have passive ideation (i.e., thoughts that life is not worth living), but may not have active suicide ideation, intent, plan, or an attempt within the previous 6 months. 4. adolescents cannot currently be engaged in or yoga classes, as this is the study intervention. 5. adolescents cannot be pregnant as yoga should be modified for pregnancy
electroacupuncture regulation of immune cells in herpes zoster

Conditions: Herpes Zoster; Electroacupuncture; Immune

Summary: herpes zoster (hz), caused by the varicella-zoster virus (vzv), is a common infection characterized by localized pain and blistering, with higher incidence in females. hz affects patients' physical health, mental well-being, and quality of life. the immune system is critical in hz pathogenesis. studies show acupuncture relieves pain, modulates immunity, and may lower postherpetic neuralgia (phn) risk. however, evidence is limited on whether electroacupuncture (ea) alleviates hz by modulating immune cells. using mass cytometry (cytof), this study will analyze peripheral immune cell changes pre- and post-ea to explore its regulatory effects on hz immunity. this study will recruit hz patients and healthy controls (hc), dividing patients into medication-only and medication+ea groups to assess ea's potential immunomodulatory effects in hz treatment.

the study will enroll 8 hz patients who meet the inclusion criteria and 3 age- and gender-matched healthy controls (hc). hz patients will be randomly assigned in a 1:1 ratio to a medication-only group or a medication plus electroacupuncture group. all participants will receive valacyclovir hydrochloride tablets and mecobalamin tablets. hz-related immune cells in peripheral blood will be analyzed using cytof before treatment (day 0), during treatment (day 4), and after treatment (day 7). pain intensity and characteristics will be assessed using the visual analogue scale (vas) and the douleur neuropathique 4 (dn4) questionnaire. lesion healing (time to vesicle cessation, crusting, and scab detachment) and adverse events will also be recorded to evaluate lesion regression in hz patients.

Eligibility criteria:
inclusion criteria for hz: * meets hz diagnostic criteria; * female, aged between 50 and 70 years; * disease duration ≤7 days, with no prior antiviral, analgesic, or other treatments; * herpetic lesions limited to the trunk, within 1 to 3 dermatomes; * willing to participate in the trial and has signed the informed consent form. inclusion criteria for hc: * no history of hz or major cardiovascular, respiratory, digestive, urinary, hematologic, endocrine, or neurological diseases; * age-matched female hc volunteers for the hz group; * clear consciousness and ability to communicate normally; * fully understands the study protocol, demonstrates good compliance, and is willing to cooperate with the study; * has signed a written informed consent form. exclusion criteria: * special types of herpes zoster, including ophthalmic, otic, visceral, meningeal herpes zoster, and zoster sine herpete; * women who are planning to conceive, pregnant, or breastfeeding; * patients with severe primary diseases of the circulatory, respiratory, or endocrine systems, or systemic failure; * patients with bleeding tendencies; * use of corticosteroids or immunosuppressants within the past month.
evaluation of the safety of c-spine clearance by paramedics

Conditions: Fracture of Cervical Spine

Summary: the goal of this cohort study is to evaluate the safety and potential impact of an active strategy that allows paramedics to assess very low-risk trauma patients with the canadian c-spine rule (ccr) and transport them to the emergency department without immobilization. the specific objectives of the study are to determine safety, determine the clinical impact and evaluate performance.


Eligibility criteria:
inclusion criteria: * consecutive alert, stable adults evaluated by the paramedics with potential c-spine injury after sustaining acute blunt trauma. patient eligibility will be determined at the time of paramedic arrival at the scene based on the following criteria: * "potential c-spine injury after sustaining acute blunt trauma" will include patients with either: * neck pain with any mechanism of injury (subjective complaint by the patient of any pain in the posterior aspect of the neck), * no neck pain but some visible injury above the clavicles, and/or * neither neck pain nor visible injury, but significant mechanism of injury as determined by the paramedic at the scene. * "alert" is defined as a glasgow coma scale score of 15 (converses, fully oriented, and follows commands). * "stable" refers to normal vital signs(systolic blood pressure 90 mm hg or greater and respiratory rate between 10 and 24 breaths per minute). * "acute" refers to injury within the past 4 hours. exclusion criteria: * patients under the age of 16 years, * patients with penetrating trauma from stabbing or gunshot wound, * patients with acute paralysis (paraplegia, quadriplegia), * patients with known vertebral disease (ankylosing spondylitis, rheumatoid arthritis, spinal stenosis, or previous cervical spine surgery), or * patients referred from another hospital and transported between facilities.

Keywords: cervical-spine injuries cervical-spine fractures spinal cord injury neck injury canadian c-spine rule paramedics emergency medical services
comparison of upper extremity exercise capacity and adl between subjects with bronchiectasis and healthy controls

Conditions: Bronchiectasis

Summary: bronchiectasis is a chronic lung disease characterized by permanent dilatation and destruction, resulting from the destruction of elastic tissue and muscular components in the bronchial walls, due to infection or inflammation. the exercise tolerance, physical activity level, respiratory and peripheral muscle strength of patients with bronchiectasis are lower than those of healthy individuals. the decrease in exercise tolerance occurs while performing upper extremity activities as well as lower extremity tasks. many studies have reported that upper extremity exercise capacity is reduced in chronic obstructive pulmonary disease (copd), a disease similar to bronchiectasis, and that patients often experience significant dyspnea and fatigue during upper extremity tasks that are important for daily life. the mechanisms causing this situation may be neuromechanical dysfunction of the respiratory muscles (diaphragm and accessory respiratory muscles) (thoracoabdominal asynchrony) and changes in lung volume in activities involving the upper extremities. the disturbances in ventilatory mechanics in patients with copd cause upper extremity exercise to be terminated at low workloads compared to healthy individuals. upper extremity exercise has been defined as part of pulmonary rehabilitation. the determination of upper extremity exercise capacity may play a predictive role in maintaining and improving upper extremity and daily life activity level in patients with chronic lung disease. six-minute pegboard and ring test (6pbrt) is used to evaluate extremity exercise capacity and upper extremity function and endurance. the 6pbrt score and upper extremity daily living activities show a clear relationship in patients with copd, and it can be used to determine and improve the performance of daily living activities in pulmonary rehabilitation programs. glittre activities of daily living (glittre adl test) covers activities that are necessary for daily living and commonly used activities. the glittre adl test produces similar cardiorespiratory responses when compared with the six-minute walk test. in this study, unsupported upper extremity exercise capacity and upper extremity function/endurance and the performance of daily living activities will be compared in participants with bronchiectasis and compared with healthy individuals.


Eligibility criteria:
inclusion criteria: * diagnosed with bronchiectasis and being clinically stable, * being 18 years old or older, * being able and willing to complete the informed consent process. exclusion criteria: * individuals with bronchiectasis whose clinical condition is unstable, * individuals with bronchiectasis who have severe neuromuscular, musculoskeletal, and rheumatological problems, * being unable to cooperate, * not being willing to participate in the study the healthy controls will be composed of individuals who volunteered for the study without any known disease. healthy individuals who did not volunteer to participate in the study will not be included.
assessments in stress and quality of sleep/life in night-shift nurses and doctors

Conditions: Shift-Work Sleep Disorder

Summary: this study aims to evaluate the effects of aroma massage to sleep quality of the nurses and staff during night shift.

night shift increases physical and psychological pressure, and even affects their sleep quality. this study aims to evaluate the effects of aroma massage to sleep quality of the nurses during night shift after life-style modification and/or aroma massage. the investigators adopt a randomized controlled trial (rct) in this study. the investigators expect aroma massage would improve the sleep quality during night shift.

Eligibility criteria:
inclusion criteria: * shift-work nurses and staff exclusion criteria: * diabetes mellitus, cardiovascular disease and psychological disorders