Kornimate/medical-research-clean huggingface dataset:
molecular imaging of brain inflammation in depressive disorders

Conditions: Depressive Disorder, Major; Positron-Emission Tomography

Summary: in a number of neuropsychiatric disorders such as depression, both brain inflammation and glutamate mediated excitotoxicity (cell death through over-activated stimulation) are suspected to play a key role. it is difficult, if not impossible, to determine the potential destructiveness of the inflammatory response seen in disease states by studying the brain's inflammatory cells (microglia) activity in isolation. the investigators are proposing to develop the means to concurrently study inflammatory response (i.e., microglial activity) and its potentially devastating consequence (i.e., glutamate excitotoxicity) across the entire brain in order to establish the importance of inflammation. in this study the investigators propose a phased clinical study whereby the early-phase involves the development of our capacity to study inflammation-mediated damage to brain cells, followed by a feasibility study in patients with clinical depression that tests whether concurrent inflammation and glutamate excess could be measured in key brain regions associated with a depressed mood state.


Eligibility criteria:
inclusion criteria: * screening form for mri/pet is satisfactory after being reviewed by a radiologist * diagnosed with depression or healthy control participants with no present mental health disorder * good general health with no diseases expected to interfere with the study * subject is not pregnant, lactating, or of childbearing potential (must be practicing effective form of birth control) * patient and healthy controls must not have an infection or an autoimmune disorder or persistent inflammation. exclusion criteria: * any significant systemic illness or unstable medical condition which could lead to difficulty complying with the protocol * use of investigational agents within last month
point-of-care multiplex for adult patients with severe community-acquired pneumonia

Conditions: Community-acquired Pneumonia; Critical Illness

Summary: clinical impact on point-of-care multiplex pcr testing for critically ill adult patients with community-acquired pneumonia - a cluster randomization study in icu units within one medical center.

point-of-care multiplex pcr testing could narrow down the pathogens causing severe community-acquired pneumonia(cap). our hypothesis is that the result of point-of-care multiplex pcr testing could help primary physician to reduce antibiotics use.

Eligibility criteria:
inclusion criteria: * adult patients (age \>20 y/o) * icu admission for acute respiratory failure due to community-acquired pneumonia by clinical diagnosis * treatment with endotracheal intubation exclusion criteria: * aspiration pneumonia (including witnessed aspiration and chronic bedridden status) * nosocomial infection

Keywords: community-acquired pneumonia critical illness point-of-care
respiratory effects of e-cigarettes in obese youth

Conditions: E-Cig Use

Summary: to determine vaping behaviors and respiratory function in obese and nonobese youth e-cigarette users.

the investigators hypothesize that obese youth e-cigarette users will have increased e-cigarette use that will worsen respiratory function. the approach will involve a clinical trial where vaping behaviors (using puff topography) and respiratory function (spirometry, plethysmography, and diffusion capacity) will be assessed while participants vape with their own e-cigarette and, on a separate visit, with the vuse e-cigarette.

Eligibility criteria:
inclusion criteria: * a current e-cigarette user (≥1 vaping bout daily) for at least the past 3 months, * 21-25 years old, * willing to abstain from all tobacco and nicotine for at least 12 hours prior to lab sessions, * willing to complete five lab visits lasting up to 4 hours each, * able to read and speak english, * willing to provide informed consent. exclusion criteria: * self-reported diagnosis of lung disease including asthma or cystic fibrosis * history of cardiac event or distress within the past 3 months * history of metabolic disease including thyroid disease or diabetes * history of orthopedic or neuromuscular problems that preclude exercise * currently pregnant (determined using urine pregnancy test), planning to become pregnant, delivered a child in the past 6 weeks even if not breastfeeding, or currently breastfeeding * use of other tobacco products \>10 days in the past month * current marijuana use \>10 times per month * currently engaging in a vaping cessation attempt * ) competitive athlete or individual currently engaged in an exercise training program involving 420min or more (moderate intensity aerobic activity) or 210 min or more (vigorous intensity aerobic activity) per week with the goal of participating in a competitive event or marathon, triathlon, etc. participants who are engaged in usual physical activity (e.g., walking dog, biking to work, etc.) but not engaged in a "structured exercise training program" will not be excluded. * plans to leave the columbus or central ohio region within the next year.
short-term automated longitudinal analysis of speech and language in cognitive impairment

Conditions: Mild Cognitive Impairment; Dementia

Summary: validate speech analysis ai models: * to contrast the accuracy of accexible's platform as a screening tool in the detection of people with cognitive impairment and mild dementia. * to evaluate the correlation between automatically analyzed linguistic variables and a combination of standard measures of cognition. * to assess short-term variability in language ability among older adults, and to assess which aspects of language vary during the study period.


Eligibility criteria:
inclusion criteria: * adult patients 55+ years of age with suspected mci or diagnosis of dementia and obtains a score greater than 20 on the mmse. * patients must have agreed to participate in the study and have voluntarily signed the informed consent. * (healthy) participants without a diagnosis neurological, or psychiatric disorders. or taking medication that can affect cognitive abilities. exclusion criteria * to have received a diagnosis of a significant psychiatric disorder or other cognitive impairment not due to neurodegeneration. * to have significant vision problems that would affect the ability to perceive visual stimuli. * to have significant hearing problems that would affect the ability to understand verbal cues.
kerastat(r) cream for radiation dermatitis

Conditions: Radiation Dermatitis

Summary: the primary objectives of the proposed research are to evaluate patient use of kerastat cream and collect data to inform a larger future trial.

the primary objectives of the proposed research are to evaluate patient use of kerastat cream and collect data to inform a larger future trial. the secondary objectives are to assess the safety and tolerability of kerastat cream in subjects at risk of radiation dermatitis, to assess the effectiveness of kerastat cream and how that compares to the current standard of care, and to estimate the amount of kerastat cream used per patient and coverage on skin.

Eligibility criteria:
inclusion criteria: 1. age 18 to 70 2. female 3. diagnosis of breast cancer and scheduled to receive 4 to 6 weeks of radiation therapy (radiation dose of 42 gy or more) 4. able and willing to sign protocol consent form 5. able and willing to document symptoms and treatment details as often as needed, not to exceed daily notes 6. able and willing to have photographs of the affected area taken regularly exclusion criteria: 1. women who are pregnant, lactating/nursing or plan to become pregnant 2. previous radiation therapy to the area to be treated with radiation therapy 3. receiving palliative radiation therapy 4. unhealed or infected surgical sites in the irradiation area 5. patients undergoing cytotoxic chemotherapy or concurrent herceptin as part of overall treatment plan (tamoxifen/aromatase inhibitor allowed) 6. use of oral corticosteroids or topical corticosteroids in the irradiation area 7. autoimmune disease 8. skin disease in target irradiation area 9. known allergy to the standard of care or ingredients in kerastat cream
internet-based clinical information and blood sample collection from patients with non-small cell lung cancer who never smoked cigarettes

Conditions: Lung Cancer

Summary: rationale: gathering health information about patients with non-small cell lung cancer who never smoked cigarettes may help doctors learn more about the disease. collecting and storing samples of blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and identify biomarkers related to cancer. purpose: this research study is studying internet-based clinical information and blood sample collection from patients with non-small cell lung cancer who never smoked cigarettes.

objectives: * to assess the feasibility of an internet-based protocol to collect clinical information and biological specimens from 2,000 never smokers with non-small cell lung cancer. * to perform genome-wide association studies to identify alleles that predispose to lung cancer in patients that never smoked cigarettes. outline: patients complete an internet-based questionnaire using the redcap (research electronic data capture) survey to determine eligibility. the survey consists of a detailed smoking questionnaire and questions to collect information regarding diagnosis, sex, age, ethnicity, treatment history, and any history of previous malignancies. blood samples are then collected from eligible patients for dna and other laboratory analyses. patients' pathology reports are also reviewed.

Eligibility criteria:
inclusion criteria: * 18 years or older * histologically and/or cytologically proven diagnosis of non-small cell lung cancer * never smoker, defined as having smoked less than 100 cigarettes over one's life-time * completed survey and inclusion form * signed informed consent exclusion criteria: * previous history of cancer (other than lung cancer, except for superficial skin cancers) * living outside the united states * patients who cannot read english (as materials will only be written in english) * unable to understand the protocol or to give informed consent

Keywords: non-small cell lung cancer
a study of hgs1029 in subjects with relapsed or refractory lymphoid malignancies

Conditions: Lymphoid Malignancies

Summary: the purpose of this study is to determine if hgs1029 is safe and well tolerated in patients with relapsed or refractory lymphoid malignancies.


Eligibility criteria:
inclusion criteria: * confirmed relapsed/refractory lymphoid malignancies * previously treated with at least 2 therapeutic regimens * ecog performance \< 2. * life expectancy of at least 3 months * adequate renal function * adequate hematologic status * adequate liver function * transfusion independent exclusion criteria: * received other therapy (biological or drug) to treat cancer within 4 weeks prior to starting treatment with hgs1029 or who exhibit persistent clinical evidence of cancer treatment toxicity * the use of systemic corticosteroids within 1 week of starting treatment with hgs1029 * evidence of active bacterial, viral or fungal infection within 2 weeks before starting treatment with hgs1029 * known hiv infection * positive for hepatitis b surface antigen or positive hepatitis c antibody * grade 2 or greater neuropathy * pregnant female or nursing mother * males or females who do not agree to use effective contraception during the study and through at least 30 days after the last dose of hgs1029
standard follow-up program (sfp) for lung cancer patients treated with radiotherapy or chemoradiation

Conditions: Lung Cancer

Summary: motive: in order to improve the treatment technique, a comprehensive follow-up program is needed to obtain all relevant patient, treatment and toxicity data from lung cancer patients. goal: to set-up and maintain a database containing treatment results in terms of tumor control, side effects, complications and patient-reported quality of life. a standard database of patients receiving photon treatment will be created. these data are then linked to dose-volume data of radiotherapy, with the aim to build prediction models for both tumor control and toxicity after radio (chemo) therapy that can later be used for selecting patients for proton treatment.


Eligibility criteria:
inclusion criteria: * patients with nsclc or sclc-ld or thymoma or lung metastases (treated with stereotactic radiotherapy) * patients receiving radiotherapy dose \> 40 gy exclusion criteria: * failure to comply with any of the inclusion criteria

Keywords: acute toxicity late toxicity prediction models
exercise and sauna on blood pressure and cardiovascular health

Conditions: Cardiovascular Risk Factor; Heat Stress; Sedentary Behavior

Summary: the study aims to investigate the effects of including regular heat therapy when included to exercise. specifically, participants in the sauna intervention group will undergo 15 minutes of sauna exposure immediately after a 50-minute session of exercise, 3 times a week, while participants in the exercise intervention group will follow only the same exercise protocol. the 50-minute exercise session consists of 20 minutes of moderate intensity strength exercise, followed by 30 minutes of moderate-vigorous aerobic exercise on stationary bikes. this exercise intervention protocol was selected in order to meet and adhere to the recommended physical activity guidelines.

the main purpose of the experiment is to investigate the cardiovascular modulations of sauna use with respect to vascular compliance and hemodynamics. the investigators seek to understand the long-term adaptations of regular sauna bathing in conjunction with exercise, particularly in sedentary populations with cardiovascular risk factors. of particular interests are the cardiovascular adaptations of regular sauna bathing when used in conjunction with exercise training; which meets the recommended minimum of current physical activity guidelines. recent studies have shown that long-term sauna use with exercise is more effective than sauna use alone in patients with chronic heart failure. however several questions pertaining to regular exercise in combination with sauna use remain to be answered, as experimental data in the general population is still lacking. this research project aims to find out the differences (if any) in cardiovascular and hemodynamic-related outcome parameters, between regular exercise according to the minimum recommended guidelines, and the same exercise program with an additional regular 15 minute sauna session post exercise. the training intervention will last for 8 weeks, with each session consisting of 20 minutes of moderate intensity resistance training, followed by 30 minutes of aerobic training. participants in the exercise only group rested in the training area for 15 minutes while the exercise and sauna participants went to the sauna for 15 minutes. temperature of the sauna room was increased by 5 degrees celsius every fortnight starting from 65 degrees celsius; during the final 2 weeks of the intervention the sauna temperature was at 80 degrees celsius. (65, 70, 75, 80). participants were told that they could leave the sauna room anytime they felt uncomfortable or if they wish to.

Eligibility criteria:
inclusion criteria: * at least one conventional cardiovascular risk factor but asymptomatic for coronary heart disease or diabetes exclusion criteria: * use of sauna more than once a week, * exercise more than 30 minutes a week, * low blood pressure, * any diagnosed and/or symptomatic cardiovascular disease, * musculoskeletal injury, * any other physical or mental condition that will prohibit the participation in the experiment, * participation to any other study at the same time.
effects of kaltenborn and mulligan mobilisation in patients with carpal tunnel syndrome.

Conditions: Carpal Tunnel Syndrome (CTS)

Summary: carpal tunnel syndrome is the most common mononeuropathy that results from the compression of median nerve in carpal tunnel, leading to entrapment neuropathy. the symptoms become aggravated during drawing, typing or playing video games. the aim of study will be to compare the effects of kaltenborn and mulligan mobilisation on pain, disability and hand function in patients with carpal tunnel syndrome.

this research will adopt a randomized clinical trial design. upon approval of the synopsis, ethical clearance would be taken and necessary permissions from ejaz hospital lahore. through convenience sampling technique, 48 patients will be included which will be allocated using simple random sampling through sealed opaque enveloped into group a and group b. mobilisation technique includes moving the proximal row of carpal bones either dorsally to promote wrist extension or to the palmar side to promote wrist flexion. group a will be treated with grade 3 kaltenborn mobilisation. grade 3 distraction was chosen to avoid contact between the articular surfaces and to stimulate hypoalgesic factors and group b will be treated with mulligan mobilisation. outcome measures will be conducted through pain, disability and hand function questionnaire after 6 weeks. data will be analyzed during spss software version 25. after assessing normality of data by shapiro-wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.

Eligibility criteria:
inclusion criteria: * both genders between 20 and 45 years of age * individuals having localized pain, tingling and numbness in the median nerve distribution * positive tinel sign and positive phalen's test exclusion criteria: * any sensory and/or motor deficit in either the ulnar or radial nerve traumatic neck injury * previous hand surgery or trauma or cervical radiculopathy * systemic disease e.g. diabetes mellitus or thyroid disease or rheumatoid arthritis

Keywords: kaltenborn, mulligan, pain, disability, hand function, cts
eyelash line resection for entropion associated with down's syndrome

Conditions: Down's Syndrome

Summary: surgical outcome of entropion associated with down's syndrome was evaluated. grading scale of superficial punctate keratopathy and score of wearing glasses to correct refractive errors were measured.


Eligibility criteria:
inclusion criteria: * the patients with entropion with down's syndrome exclusion criteria: * the patients of down's syndrome who do not have entropion.

Keywords: down's syndrome entropion lid plasty
impact of a patient-centered program for low anterior resection syndrome a multicenter randomized controlled trial

Conditions: Rectal Cancer; Surgery; Patient Activation; Low Anterior Resection; Low Anterior Resection Syndrome

Summary: after undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as low anterior resection syndrome (lars). increased lars severity correlates with worse perceived global health status and quality of life (qol). among patients undergoing rectal resection with a permanent ostomy, there is evidence that supportive and educational interventions improve qol, ostomy proficiency, self-efficacy and knowledge. however, evidence regarding the impact of such interventions in patients who undergo restorative proctectomy is lacking, despite the latter operation being far more frequently performed. the overall goal of this study is to evaluate the extent to which a lars patient-centered program impacts on patient-reported outcome measures (proms) after restorative proctectomy for rectal cancer. this is a randomized-controlled muticenter trial that will include patients who have undergone restorative proctectomy for neoplastic disease (benign or malignant) located in the rectum (0-15cm from the anal verge) with a diverting ostomy and who are scheduled for ostomy closure.


Eligibility criteria:
inclusion criteria: * adult patients (\>=18 years-old) who have undergone restorative proctectomy for neoplastic disease (benign or malignant) located in the rectum (0-15cm from the anal verge) with a diverting ostomy and who are scheduled for ostomy closure exclusion criteria: * patients from whom clear and informed consent cannot be obtained * patients unable to read and comprehend english or french * patients who cannot be contacted by telephone * patients who have undergone major colonic resection in addition to their proctectomy * patients on active chemotherapy or radiotherapy treatment
the effect of different fiberoptic outer diameters on fiberoptic intubation

Conditions: Intubation Times

Summary: fiberoptic intubation is an important method for anesthesiologists to deal with difficult airways, but its operation is difficult and requires repeated practice. fiberoptic intubation is performed in two steps. first, the anesthesiologist holds the bronchoscope and exposes the base of the tongue, the epiglottis, and the glottis successively according to the front camera of the bronchoscope. through the glottis, the main trachea is exposed to the carina. this process is visual and the anesthesiologist can see the main tissue structure directly. then, the endotracheal catheter enters the endotracheal along the bronchoscope, and the process of endotracheal catheter entry is not visual. in clinical work, it was found that the tracheal catheter was easily blocked when it passed through the glottis, and it was necessary to adjust the position of the tracheal catheter for several times before the tracheal catheter could be sent into the tracheal tube, which was easy to cause throat injury in the process. at present, relevant studies are mainly focused on the first step of bronchoscopic intubation, how to quickly expose the glottis and complete the bronchoscopic guidance process. however, there is no clear mention of the situation of catatoning in the process of endotracheal catheter and how to solve the problem of catatoning.

according to the inclusion and exclusion criteria，collecting the data of participants who undergone fiberoptic intubation. the observer analysis the safety and efficiency of fiberoptic intubation.

Eligibility criteria:
inclusion criteria: 1.american society of anesthesiologists 1\~2 2.18-60 year 3.adult patients requiring general anesthesia for orotracheal intubation exclusion criteria: 1. limited mouth opening 2. limited movement of temporomandibular joint 3. abnormal glottic anatomy 4. polyps of vocal cords

Keywords: intubation ffiberoptic perioperative sore throat success rate