Kornimate/medical-research-clean huggingface dataset:
efficiency of different gastrocnemius stretching exercises

Conditions: Muscle Tightness

Summary: the primary aim of this study is to investigate the effects of different types and durations of gastrocnemius stretching on the viscoelastic properties of the gastrocnemius muscle, achilles tendon, and plantar fascia.in addition, pain threshold of the gastrocnemius muscle and plantar fascia, as well as on hamstring tightness will be measured.

the study will include a total of at least 48 individuals who meet the inclusion and exclusion criteria. subsequently, participants will be randomly assigned to one of four groups for gastrocnemius stretching exercises of different durations and types. participants in group i will perform sustained stretching with a towel, those in group ii will perform intermittent stretching with a towel, those in group iii will perform sustained stretching against the wall, and those in group iv will perform intermittent stretching against the wall. the stretching exercises will be performed under the supervision of one of the researcher. compliance with the stretching exercise will be evaluated by keeping a daily log.

Eligibility criteria:
inclusion criteria: * age of 18 to 25 years * having a gastrocnemius muscle tightness in the dominant side exclusion criteria: * history of lower extremity surgery or trauma * diagnosis of fibromyalgia, neurological disease, achilles tendinopathy, metatarsalgia, acute ankle sprain, tarsal tunnel syndrome, or heel pad syndrome * having received physiotherapy related to the lower extremities within the last six months * a body mass index (bmi) above 30 kg/m2 * having received a local steroid injection within the last six weeks * the presence of a local infection * the presence of rheumatic or other systemic inflammatory diseases * diabetes or other metabolic diseases * nerve compression syndrome * currently using painkillers * diagnosis of neurological heel pain * a positive navicular drop test result * having engaged in strenuous exercise within the last 24 hours * not being fully compliant with the exercise program

Keywords: pain threshold elasticity
early feasibility study of the neovasc tiara™ mitral valve system

Conditions: Mitral Valve Regurgitation

Summary: the purpose of this study is to evaluate the safety and initial performance of the neovasc tiara mitral transcatheter heart valve with the tiara transapical delivery system.

this is an international, multicenter, single arm, prospective, early feasibility clinical study to evaluate the safety and performance of the neovasc tiara mitral valve system in subjects with symptomatic severe mitral regurgitation requiring mitral valve replacement who are at high risk for open chest surgery. a maximum of 30 subjects will be implanted in this study at a maximum of 10 sites. a maximum of 15 subjects will be implanted in the united states. subjects satisfying the inclusion criteria and exclusion criteria will be enrolled to receive the neovasc tiara mitral transcatheter heart valve with the tiara delivery system via a transcatheter mitral valve replacement (tmvr) procedure.

Eligibility criteria:
inclusion criteria: * severe symptomatic mitral regurgitation (stage d) * high surgical risk for open mitral valve surgery * subject meets the anatomical eligibility criteria for available size(s) * nyha class iii or iv heart failure exclusion criteria: * dmr deemed by the heart team to be operable. * prohibitive risk, deemed too frail or listed for cardiac transplant. * unsuitable cardiac structure

Keywords: mitral regurgitation heart valve transcatheter transapical functional degenerative symptomatic, severe mitral valve regurgitation, high risk for open mitral valve surgery
computer guided versus conventional tmj injection

Conditions: TMD

Summary: this study is designed to evaluate the clinical outcomes of computer-guided sodium hyaluronate injection in superior joint space in comparison to conventional injection for treatment of intra-articular tmj disorder.

this study aimed to reveal the superiority of computer-guided tmj injection (if found) above the conventional method from the clinician and patient point of view.

Eligibility criteria:
inclusion criteria: * patients diagnosed with intra-articular tmj disorder according to research diagnostic criteria for temporomandibular disorders (rdc/tmd). * patients who would not respond to conservative treatment as the first line of treatment. exclusion criteria: * patients with polyarthritis or degenerative joint disease. * patients with myofascial pain. * previous history of minimally invasive or invasive treatment of tmj. * history of mandibular fracture. * lactating, pregnant or planning pregnancy women. * known hypersensitivity to hyaluronic acid or clear biocompatible photopolymer resin.

Keywords: tmd
assessment of the need to use short cognitive tests for french general practitioners/family doctors

Conditions: Cognitive Disorder

Summary: the prevalence of cognitive disorders is constantly increasing, with 1.2 million patients affected in france in 2016. dementia is currently the seventh leading cause of death. in the absence of available treatment, systematic screening is not recommended. however, cognitive evaluation is recommended to maintain a level of autonomy for the patient at home. targeted screening is the responsibility of the general practitioner. the latest recommendations from the has (2011) highlight the use of the mmse as a first-line approach, there are no recommendations regarding short tests. early cognitive assessment is limited by the time required to perform the tests and the knowledge about the available tools. the codex is a short test, its sensitivity (92%) and specificity (85%) place it among the most discriminatory scores. it is underutilized in france. the objective of this thesis is to assess the training needs of general practitioners in short tests.


Eligibility criteria:
inclusion criteria: * general practitioners of the aura region, in activity, university supervisor or not, trained or not trained in geriatrics. exclusion criteria: * general practitioners with exclusive practices in pediatrics, gynecology, aesthetics, rehabilitation, and homeopathy.

Keywords: cognitive evaluation short test general practitioners codex, training formation
acceptance and commitment therapy for patients with multi-organ bodily distress syndrome (stress-4)

Conditions: Somatisation Disorder; Somatoform Disorders

Summary: the aim of this study is to test the effect of acceptance and commitment therapy (act) in patients with long lasting health problems with no known medical explanation, defined as multi-organ bodily distress syndrome (bds). act treatment is given as two different types of treatment, a 9-session group therapy and a 1-day workshop followed by an individual consultation, and both are compared to standard treatment, which is one single advisory consultation. the study includes 180 patients.

the aim of this study is to test the effect of acceptance and commitment therapy (act) in patients with multi-organ bodily distress syndrome (bds). bds is a unifying diagnosis that encompasses a group of closely related conditions such as somatization disorder, fibromyalgia, irritable bowel syndrome and chronic fatigue syndrome. the project consists of a three-armed randomized controlled trial of act treatment given as a supplement to standard treatment as either 9-session group therapy or as a 1-day workshop followed by an individual consultation, compared to standard treatment, which is one single advisory consultation. primary outcome is patient-rated improvement measured by clinical global improvement scale (cgi-i). secondary outcome is functional level (physical, mental and social) measured by the sf-36 physical component summary (pcs). the study includes 180 participants.

Eligibility criteria:
inclusion criteria: 1. first time refered patients fulfilling diagnostic criteria for bds multi-organ type with symptoms for more than 3 of 4 symptom categories 2. moderate or severe impact on daily life 3. symptoms lasting for at least 2 years 4. age 20-50 years 5. born in denmark or have danish parents. the patient understands, speaks, writes and read danish. exclusion criteria: 1. presence og other physical of psychiatric condition, if the symptoms of this condition can not clearly be separated from symptoms of bds 2. patients with treatment demanding psychiatric disease as dominating problem 3. a lifetime-diagnosis of psychoses, mania or depression with psychotic symptoms (icd-10: f20-29, f30-31, f32.3, f33.3) 4. abuse of alcohol, narcotics or drugs 5. pregnancy at time of inclusion

Keywords: bodily distress syndrome medically unexplained symptoms functional somatic symptoms functional somatic syndromes treatment acceptance and commitment therapy
clinical trial of yh32367 in patients with her2 positive locally advanced or metastatic solid tumor

Conditions: HER2-Positive Solid Tumor

Summary: this first-in-human study will be counducted to evaluate the safety, tolerability, pharmacokinetics (pk) and anti-tumor activity of yh32367 in patients with her2-positive locally advanced or metastatic solid tumors.

yh32367, a novel her2/4-1bb bispecific antibody (bsab), simultaneously targets her2 and h4-1bb and binds to both targets. yh32367 exhibits a strong 4-1bb signal activation as well as blocking of her2 signaling in her2-expressing tumor cells. yh32367 stimulates ifn-γ secretion from t cells and thereby induces tumor cells lysis. this is a phase 1/2, open-label, multicenter, first-in-human study of yh32367. this 2-part study will include both a dose escalation part, to identify the maximum tolerated dose (mtd) and/or two dose levels for rp2d selection, and a dose expansion part, to determine rp2d and to confirm the safety, tolerability and efficacy of yh32367 at the rp2d.

Eligibility criteria:
inclusion criteria: \[dose escalation part\] * pathologically confirmed her2-positive * mandatory provision of tumor tissue sample \[dose expansion part\] * patients who have at least one measurable lesion * mandatory provision of tumor tissue sample 1. cohort 1: pathologically confirmed her2-positive biliary tract cancer 2. cohort 2: pathologically confirmed her2-positive metastatic solid tumor malignancy other than breast and gastric or gastroesophageal junction adenocarcinoma and biliary tract cancer exclusion criteria: * uncontrolled central nervous system (cns) metastases * spinal cord compression * carcinomatous meningitis * acute coronary syndromes * heart failure * interstitial lung disease (ild) * pneumonitis * history of a second primary cancer * human immunodeficiency virus (hiv) * active chronic hepatitis b * hepatitis c * systemic steroid therapy * autoimmune disease

Keywords: yh32367 her2/4-1bb bispecific antibody solid tumor breast cancer gastric cancer her2-positive biliary tract cancer
use of armodafinil for fatigue in sarcoidosis

Conditions: Sarcoidosis; Fatigue; Sleepiness

Summary: to determine the effect of armodafinil (nuvigil) on fatigue and sleep in sarcoidosis.

the study will be divided into two halves. patients will receive either drug or placebo in the first half. patients receiving active drug will be started at one dose and it can be increased at the second visit. those patients randomized to placebo will also have their dose adjusted by the investigating physician. the physicians will be blinded as to whether the patient is receiving drug or placebo. in the second half of the study, patients will receive the opposite treatment. patients will have complete detailed questionnaires regarding their fatigue, sleepiness, and overall quality of life. they will have sleep studies done at the start and after each half of the study to determine the effect of therapy on sleepiness.

Eligibility criteria:
inclusion criteria: * diagnosis of sarcoidosis using standard criteria 15. * disease for more than one year * on stable, systemic therapy * complain of fatigue which has been present for more than six months. * over 18 years of age * provide written informed consent. exclusion criteria: * pregnancy * change in therapy for sarcoidosis in prior three months * history of ventricular arrythmias

Keywords: sarcoidosis fatigue
cognitive rehab and exposure treatment for hoarding

Conditions: Hoarding Disorder

Summary: this project will utilize a novel behavioral intervention for hoarding disorder that takes into account age and neurocognitive factors. the goal of this project is to gain knowledge on how treatment components may or may not work for veterans with hoarding disorder. further, the investigators hope to increase understanding of functional and long term outcomes in response to hoarding treatment.

objective: the investigators propose to conduct a randomized controlled trial comparing six months (26 sessions) of cognitive rehabilitation and exposure/sorting therapy (crest) treatment to a robust comparator, six months of exposure therapy alone, in 136 participants with hd. research design: assessments will be administered at baseline, during treatment (sessions 7, 13, 21), post-treatment, and 3- and 6-month follow-up, thus, all participants will be enrolled for one year. methodology: the primary objective is to evaluate whether crest significantly reduces hoarding symptoms and improves functional capacity and quality of life when compared to exposure therapy alone. the investigators will also examine the impact of treatment mediators; treatment adherence, changes in executive functioning, avoidance, symptom severity on outcomes. age and executive functioning will also be explored as potential moderators. finally, by repeatedly measuring treatment targets, the investigators will examine time to maximum treatment effect in an effort to understand mechanisms of change. clinical relationships: by providing a treatment for many veterans with hd, the investigators can alter the course of their symptom trajectory and negative consequences, resulting in both healthcare costs savings and improved quality of life for veterans.

Eligibility criteria:
inclusion criteria: * veterans age 18-85 * hoarding disorder diagnosis outlined by the diagnostic and statistical manual of mental disorders, fifth edition (dsm-5)6 as measured by the structured interview for hoarding disorder (sihd)67 * hd as a primary diagnosis * stable on medications for at least 12 weeks, with no pharmacologic changes expected or made during the 12-month study * voluntary consent to participate exclusion criteria: * diagnosis of: * psychotic disorder * substance abuse disorder as measured by the mini-international neuropsychiatric interview (m.i.n.i.)68 * current or history of any neurodegenerative disease * active suicidal ideation * concurrent participation in psychotherapy or et for hd, or prior history of crest for hd

Keywords: hoarding compulsive hoarding
inducibility and stability of ventricular tachycardia inpatients undergoing vt ablation under general anesthesia

Conditions: Ventricular Tachycardia

Summary: this research study is being done to see whether general anesthesia (ga) affects our ability to start ventricular tachycardia (vt) during an vt ablation procedure. data collected during this research study will help electrophysiologists and anesthesiologists to make the best decisions about the best anesthetic conditions to use to perform vt ablations. this research study is a "pilot" study. pilot studies are done on a small group of subjects to learn if a larger study would be useful.


Eligibility criteria:
inclusion criteria: * patients with vt and have an implanted icd who are scheduled for vt catheter ablation. * patients 18 years of age or older exclusion criteria: * patients with difficult airway management or patients with contra/ relative contra indication for general anesthesia or known allergies to any of the proposed anesthetic agents * women who are pregnant

Keywords: ventricular tachycardia ventricular tachycardia ablation effects of anesthesia on vt induction programed stimulation
rivaroxaban in elderly nvaf patients with or without renal impairment

Conditions: Atrial Fibrillation; Rivaroxaban; Elderly; Renal Insufficiency

Summary: study type and design prospective, observational study rivaroxaban in elderly af patients with or without renal impairment in korea this study will investigate effectiveness and safety in elderly patients, the result from well-designed and high-quality prospective clinical registry collected through real-world clinical practice is expected to resolve current medical unmet needs of rivaroxaban in korean elderly patients. primary study objective(s) to investigate the effectiveness of rivaroxaban in elderly patients with nvaf, with or without renal impairment in korea real-world clinical practice settings secondary study objective(s) to see safety outcome including major bleeding, clinically non-major bleeding, all-cause mortality rivaroxaban in subgroup based on risk factor(eg. renal impairment) physicians' treatment pattern in rivaroxaban

study population elderly patients with age ≥ 65 years with treatment naïve or treatment-experienced patients who are diagnosed with nvaf expected number of patient enrollment is about 1200 patients, samsung medical center is aim to enroll about 200 patients

Eligibility criteria:
inclusion criteria: 1. patients with consent given 2. elderly patients with age 65 ≥ years old 3. nvaf patients first time prescription to rivaroxaban or patients who started rivaroxaban treatment within 3 months exclusion criteria: 1. refusal to participate in this study or to give an informed consent 2. patients with moderate to severe mitral stenosis 3. patients with mechanical valve 4. contraindication from rivaroxaban korea smpc
toric contact lens performance study

Conditions: Astigmatism

Summary: this study seeks to quantify digital visual performance and subjective visual acceptance of toric contact lenses as compared to spherical lenses in low to moderate astigmatic patients.

this is a prospective, single site, randomized, masked, crossover study. this study will evaluate the ability of toric contact lenses to decrease signs and symptoms of asthenopia and improve digital reading performance. symptoms and objective near vision outcomes will be measured at baseline and after 1 week of wear with each correction.

Eligibility criteria:
inclusion +6.00 to -6.00 d vertexed sphere power and -0.75 to -1.50 d vertexed refractive cylinder in the right and left eyes best corrected acuity of 20/25 or better in each eye self report of at least 4 hrs/day using digital devices current/established soft contact lens wearer (has worn contact lenses in the past year) exclusion an optometrist or optometry student history of ocular pathology or surgery binocular vision disorder (i.e., tropia, convergence or accommodative insufficiency) gas permeable lens wear for at least 3 months presbyopic (based on refraction)
breath combined with ct for diagnoses of pulmonary nodules

Conditions: Non-small Cell Lung Cancer; Pulmonary Nodule, Multiple

Summary: pulmonary nodules diagnosis using breath test of volatile organic compound (voc) is in its infancy. the accuracy of voc analysis in diagnosing malignant pulmonary nodules varies cross the published studies. the diagnosis accuracy of voc alone is generally poor. we speculate that the accuracy of diagnosing malignant pulmonary nodules will be improved by combining breath test with chest computed tomography (ct). this study aims to establish a predictive model of malignant pulmonary nodule using bio-markers from exhaled breath and image-markers from chest ct with retrospective data from multi centers. the sensitivity, specificity and accuracy of the model will be validated prospectively.

endogenous volatile organic compounds (vocs) can be derived from many different metabolic pathways. vocs can be transported to the alveoli through the blood circulation and expelled by exhalation. changes in vocs production, clearance, and alterations in lung air-blood exchange functions can lead to aberrant vocs profiles in the exhaled breath. testing exhaled breath has the advantages of being completely non-invasive and easy to collect, and has been considered as a perfect approach for disease diagnoses and therapeutic monitoring. many clinical studies have found that vocs in exhaled breath are closely related to disease status. specific vocs alterations have been identified in many tumors, especially lung cancer. pulmonary nodules diagnosis using breath test of volatile organic compound (voc) is in its infancy. the accuracy of voc analysis in diagnosing malignant pulmonary nodules varies cross the published studies. the diagnosis accuracy of voc alone is generally poor. we speculate that the accuracy of diagnosing malignant pulmonary nodules will be improved by combining voc analysis with chest computed tomography. in this study, we use a highly sensitive mass spectrometry to detect exhaled vocs of patients with pulmonary nodules. the chest ct will be used for detecting the imaging characteristics of pulmonary nodules. the pathological diagnosis of pulmonary nodules after surgical resections is selected as golden standard. this study aims to establish a predictive model of malignant pulmonary nodule using bio-markers from breath test and image-markers from chest ct with retrospective data from multi centers. the sensitivity, specificity and accuracy of the model will be varied prospectively.

Eligibility criteria:
inclusion criteria: 1. age \> 18 years old; 2. pulmonary nodules with planned surgical resection; 3. signed informed consent and agreed to participate in this study. exclusion criteria: 1. preoperative radiotherapy, chemotherapy, targeted therapy or other anti-tumor therapy 2. the lack of chest computed tomography within two weeks before surgery 3. a history of malignant disease within 5 years.

Keywords: volatile organic compound pulmonary nodules predictive model computed tomography hppi-tofms
obese patient during rarp: the role of a preemptive ventilator strategy to contrast pneumoperitoneum and trendelenburg position

Conditions: Obese Patients With Prostate Cancer Disease

Summary: analysis of the specific elastance during general anesthesia in patients treated with rarp (robotic assisted radical prostatectomy), to evaluate the efficacy of the preemptive strategy, involving recruitment maneuver and setting of 10 cmh2o peep before induction of pneumoperitoneum and trendelenburg position.

rarp (robotic assisted radical prostatectomy) requires the induction of pneumoperitoneum and the trendelenburg position, causing increase in the intra-abdominal pressure and cephalic shift of the diaphragm, with consequent airway closure and collapse of the dependent regions of the lung. obese subjects present an increased risk of respiratory complications, caused not only by the surgical procedure itself, but also by the respiratory mechanics changes associated with the body mass. in obese patients we can observe higher values of lung and chest wall elastance, with reduction in ventilation-perfusion ratio. the partitioning between lung and chest wall elastance can improve ventilatory setting and mechanics parameters of ventilation. in every patient we will place, after anesthesia induction, a catheter to get esophageal and gastric pressure that represent pleural and abdominal pressure. ventilation will be conducted with a tidal volume of 8-10 ml/kg (ibw) and a respiratory rate adequate to maintain a physiological level of pa co2. the preemptive strategy involves recruitment maneuver and setting of 10 cmh2o peep before induction of pneumoperitoneum and trendelenburg position in the treatment group, while the current procedure provides it afterwards (control group).

Eligibility criteria:
inclusion criteria: * bmi \>= 30 * robotic-assisted laparoscopic prostatectomy exclusion criteria: * chronic cardiac or pulmonary diseases

Keywords: obese patients specific elastance trendelenburg position pneumoperitoneum robotic surgery prostatectomy