Kornimate/medical-research-clean huggingface dataset:
trabeculopuncture as predictive test for the success of ab interno trabeculectomy

Conditions: Open Angle Glaucoma; Pseudoexfoliation Glaucoma

Summary: the purpose of this study is to perform trabeculopuncture a test to determine the distal outflow tract function to predict the success of ab interno trabeculectomy.

the aim of this study is to develop a non-invasive predictive test for the function of the distal outflow tract after ab interno trabeculectomy for open angle glaucoma. we hypothesize that the ocular pressure drop and outflow change after preoperative trabeculectomy may predict the success of ab interno trabeculectomy. the results of this study should allow trabeculopuncture to be used to select the most appropriate procedure for the individual patient.

Eligibility criteria:
inclusion criteria: * individuals ≥ 18 years of age * clinical diagnosis of: primary open angle glaucoma, pigmentary glaucoma, or pseudoexfoliation glaucoma * uncontrolled intraocular pressure (iop) with maximally tolerated medical therapy * progressive thinning of retinal nerve fiber layer assessed by spectral domain optical coherence tomography (p \< 0.05) * progression of visual field defects * visually significant cataract and indication to reduce iop or glaucoma medication burden exclusion criteria: * clinical diagnosis of neovascular glaucoma, angle-closure glaucoma, uveitic glaucoma, neovascular glaucoma * prior glaucoma surgery * preexisting conditions affecting the episcleral venous pressure including grave's ophthalmopathy, sturge-weber syndrome, arteriovenous fistulas (carotid-cavernous fistula)

Keywords: ab interno trabeculectomy trabeculopuncture open angle glaucoma
prospective randomized trial comparing the effectiveness of continuous paravertebral infusion of local anesthetics versus intravenous patient-controlled analgesia on acute and chronic neuropathic pain after vats lobectomy

Conditions: Lung Neoplasms; Postoperative Pain

Summary: since mid-2000, thoracoscopic lobectomy has been replaced with conventional open lobectomy and it has reduced the operative morbidities and mortalities. however, thoracoscopic lobectomy also results in operative acute pain and the incidence of chronic pain after thoracoscopic lobectomy has been reported as up to 50%. penetration of chest wall by trocar, torque at trocar and working window by operator, and compression of intercostal nerves have been suggested as a cause of pain after thoracoscopic lobectomy. the intravenous patient-controlled analgesia (iv pca) that usually have used to control the operative pain, sometimes cause the side effects such as sedation, nausea and vomiting due to its systemic delivery of analgesics. because of these side effects, iv pca has to be discontinues and the effective dose of analgesics could not deliver to patients. in contrast to iv pca, continuous paravertebral infusion of local anesthetics thorough catheter below the parietal pleura might reduce the side effects of iv pca and control the operative pain effectively. in this study, we investigate the effectiveness of continuous paravertebral infusion of local anesthetics thorough catheter below the parietal pleura for 60 hours after operation competed to iv pca.


Eligibility criteria:
inclusion criteria: * age; 18≥, \<75 * thoracoscopic lobectomy due to lung cancer or suspected lung cancer * tolerable cardiopulmonary and other systemic function tolerable to lobectomy * karnofsky performance status ≥ 80 * agree with study exclusion criteria: * intolerable to one-lung ventilation * bleeding risk due to aspirin, coumadin and other drugs * past or current history of depression or other psychiatric disease * pain persisted before operation due to lung lesion * history of rib fracture, trauma or lung surgery at the same side of operation * severe pleural adhesion or empyema * open thoracotomy conversion * reoperation due to postoperative bleeding or others * postoperative complications that need icu care * chemical pleurodesis more than two times after operation * do not agree with study

Keywords: pain control, vats
prediction of expected length of hospital stay using machine learning

Conditions: Infection; Heart Failure; Chronic Obstructive Pulmonary Disease; Asthma; Gout Flare; Chronic Kidney Diseases; Hypertensive Urgency; Atrial Fibrillation Rapid; Anticoagulants; Increased

Summary: this is a retrospective observational study drawing on data from the brigham and women's home hospital database. sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict length of stay throughout a patient's admission. this algorithm was then validated in a validation cohort.


Eligibility criteria:
was a subject in the brigham and women's home hospital study and has a completed record in the study's database.
detection of covid-19 in saliva collection

Conditions: Sars-CoV2; RT-PCR; Saliva Collection; Nasopharyngeal Sample

Summary: since december 2019, the world has faced a pandemic of covid-19, an infectious disease caused by sars-cov-2, a virus that emerged in china. the reference diagnosis is based on the search for the sars-cov-2 genome in the nasopharyngeal sample. carrying out this sample requires the competence of a healthcare professional and presents some inconveniences for the tested patient. because saliva collection is simple, non-invasive, painless and inexpensive, and can be performed by poorly trained personnel, it could be an alternative to the reference nasopharyngeal sample. sars-cov2 detection in human saliva could be a potential diagnosis of covid infection.


Eligibility criteria:
inclusion criteria: * patient hospitalized at the amiens chu in a covid-19 unit * patient seen as outpatient in the area of infectious pathologies for covid-19 infection exclusion criteria: * patients under 18 * patients under guardianship or curators

Keywords: sars-cov2 rt-pcr saliva collection nasopharyngeal sample
heart monitoring device after acute myocardium infarction

Conditions: Acute Myocardial Infarction

Summary: verify the effectiveness of a heart monitor in preventing events in patients over 18 years after acute myocardial infarction in a clinical unit. patients with neurological disease or congenital heart disease we excluded from the study.

heart monitor can detect early intercurrences. objective: to verify the effectiveness of a heart monitoring system in preventing events in patients after acute myocardial infarction. methodology: this is a randomized clinical trial to be developed in a clinical unit and will include patients over 18 years , post-acute myocardial infarction who were transferred from the icu emergency or hemodynamic to clinical unit. patients with neurological disease or congenital heart disease will be excluded from the study.

Eligibility criteria:
inclusion criteria: * patients over 18 years * patients post-acute myocardial infarctium exclusion criteria: * patients with neurological disease * patients with congenital heart disease

Keywords: monitoring myocardial infarction clinical trial
the comparison of strategies to prepare severely calcified coronary lesions trial (prepare-calc)

Conditions: Coronary Atherosclerosis Due to Severely Calcified Coronary Lesion

Summary: the primary objective of this study is to evaluate the success of lesion preparation with either rotational atherectomy or cutting/scoring balloons as well as the long term effects of a hybrid sirolimus-eluting stent in an angiographically well-defined group of patients with complex calcified coronary lesions.


Eligibility criteria:
inclusion criteria: 1. clinical inclusion criteria * age above 18 years and consentable * angiographically proven coronary artery disease * anginal symptoms and/or reproducible ischemia in the target area by ecg, functional stress testing or fractional flow reserve * written informed consent 2. angiographic inclusion criteria * de-novo lesion in a native coronary artery * target reference vessel diameter between 2.25 and 4.0 mm by visual estimation * luminal diameter reduction of 50-100% by visual estimation * severe calcification of the target lesion exclusion criteria: 1. clinical exclusion criteria * myocardial infarction (within 1 week) * decompensated heart failure * limited long term prognosis due to other conditions 2. angiographic exclusion criteria * target lesion is in a coronary artery bypass graft * target lesion is an in-stent restenosis * target vessel thrombus
growth factor enhanced matrix with subepithelial connective tissue graft or collagen membrane in treatment of gingival recession

Conditions: GINGIVAL RECESSION

Summary: the study aimed to compare, the effectiveness of growth factor enhanced matrix (gem 21s) ® combined either with free connective tissue graft or collagen membrane in the treatment of miller class ii gingival recession.

materials and methods: twenty sites in 10 patients, with class ii miller gingival recession were allocated randomly to be treated by (gem 21s) ® with free connective tissue graft (groupi) or gem 21s with collagen membrane (groupii). plaque index, bleeding on probing, recession width, recession depth, height of keratinized tissue and digital measurements were recorded at baseline, 1, 3 and 6-months'. probing pocket depth, clinical attachment level, gingival thickness and radiographic parameters were recorded at baseline and 6 months'. root coverage percentage were recorded 6 months postoperative and wound healing index were recorded at 1,3 and 6-months' post-operative .

Eligibility criteria:
inclusion criteria: * lack of any related medical issues that contraindicate periodontal surgery, * optimum adherence as confirmed by a positive attitude towards oral hygiene, and successfully showing up for treatment appointments. * no history of any medications in the previous six months that may interfere with periodontal surgery gingival thickness for the selected sites should be \> 1mm (as measured 2mm apical to gingival margin), * clinical attachment level ≥ 4mm measured from cemento-enamel junction till the deepest probing depth. exclusion criteria: * the presence of class v caries or restoration in the site to be treated, * previous mucogingival surgery at the selected site. * teeth that are tilted, rotated, or have any occlusal abnormalities. * smokers and pregnant patients were excluded from the participation.

Keywords: gingival recession free subepithelial connective tissue graft collagen membrane growth factor enhanced matrix 21 s
time pressure motor training with step square exercise on stroke patients

Conditions: Stroke

Summary: to investigate the efficacy of time pressure motor rehabilitation with step square exercise (see) on decision making ability \& quality of life in stroke patients

purpose: to investigate the efficacy of time pressure motor rehabilitation with step square exercise (see) on decision making ability \& quality of life in stroke patients background: stroke patients demonstrate impairments in decision making ability leads to deficits in patient's quality of life.

Eligibility criteria:
inclusion criteria: * age from 50 to 65 years old * both sex * the duration of illness more than three months * post stroke hemiplegia * mild spasticity ranged from (1:1+) according to modified ashworth scale exclusion criteria: * stroke occurred less than 3 months ago * patients with severe cognitive or psychiatric impairment aphasia who could not understand the instructions given to him by physical therapist or unable to perform the task * any other orthopedic disorders or neurologic diseases.
hypokalemia in hospitalized patients for heart failure in the therapeutic cardiac failure unit

Conditions: Heart Failure

Summary: hypokalemia is very common in heart failure patients. deleterious effects have been report on the cardiovascular system. most of the clinical data concerning this ionic trouble are based on post-hoc study and some findings seemed disjointed.

this study tried to describe hypokalemia impact during hospital stay in hospitalized patients with heart failure and particularly on mortality and re-hospitalization.

Eligibility criteria:
inclusion criteria: * hospitalized patient in the therapeutic cardiac failure unit in the chr metz-thionville * patient with congestive heart failure exclusion criteria: * none

Keywords: hypokalemia cardiac failure
impact of premature childbirth on parental outcomes during baby's nicu stay and beyond

Conditions: Premature Birth

Summary: the main objective of this project is examining whether there is a relationship between preterm delivery and parental' problematic emotional bond in the early postpartum period. the secondary outcomes are as follows: * to evaluate whether there are any differences and similarities between fathers' and mothers' level of parental bonding, stress, anxiety, and depression symptoms in case of premature birth. * to evaluate whether there is a relationship between preterm delivery and the persistence of maternal' problematic emotional bond three months after childbirth. * to indicate what kind of predictors might affect the parental' problematic bond in the early postpartum period.


Eligibility criteria:
inclusion criteria: * parents of children born below the 37th week of pregnancy (clinical group) or above the 37th week of pregnancy (control group) hospitalised in a neonatal setting during recruitment period * which agreed participating to the study after having complete information about it and sign a consent. exclusion criteria: * parents may not participate in the study if one of them suffers from a serious mental illness.

Keywords: parental outcomes bonding nicu
whole body magnetic resonance imaging with diffusion weighted imaging : potential role in neurofibromatosis

Conditions: Whole Body Imaging; Magnetic Resonance Imaging; Neurofibromatosis 1; Diffusion Magnetic Resonance Imaging; Peripheral Nerve Sheath Tumors, Malignant

Summary: whole body mri will be performed in patients with neurofibromatosis type 1 purpose 1: to determine the total tumor load (neurofibroma) and to diagnose plexiform neurofibromas or malignant peripheral nerve sheath tumors. all patients will be scanned two years after the baseline whole body mri to investigate to investigate the changes of total tumor load. purpose 2: added value of diffusion weighted imaging in diagnosis of high-risk neurofibromas purpose 3 : to determine the apparent diffusion coefficient of the malignant nerve sheath tumors and neurofibroma. purpose 4 : correlation between histopathology of the surgically resected neurofibroma/malignant nerve sheath tumors and mri findings


Eligibility criteria:
inclusion criteria: * patients with neurofibromatosis type 1, between 6 and 50 years old exclusion criteria: * patients who are not allowed to be scanned on mri (contra-indications: pacemaker ed.)

Keywords: whole body imaging magnetic resonance imaging neurofibromatosis 1 diffusion magnetic resonance imaging peripheral nerve sheath tumors, malignant
web-based program in helping patients with head and neck cancer adhere to swallowing exercises and coping strategies

Conditions: Throat Carcinoma

Summary: this phase ii trial studies how well a web-based program called project prepare works in helping patients with head and neck cancer adhere to swallowing and trismus exercises and coping strategies. head and neck cancer patients who receive radiation therapy are at risk for permanent swallowing disorders and other side effects. because of these potential problems, swallowing exercises and coping strategies are important parts of recovery. a web-based program designed to increase adherence to preventive exercises may help patients with head and neck cancer ameliorate the long-term effects of radiation therapy.

primary objective: i. to determine the impact of a web-based adherence program (prepare) on self-reported swallowing function in head and neck cancer patients during radiation. secondary objective: i. to determine community participant adherence to targeted swallowing and trismus exercises delivered by the prepare website video demonstrations. exploratory objective: i. to promote the long-term dissemination of the dysphagia prevention program through measurement of patient satisfaction and engagement metrics, training and continual feedback between the md anderson cancer center (mdacc) research site and community collaborative research sites. outline: patients use the password-protected project prepare website on a computer, tablet, or phone over 10 weeks to view: videos of the swallowing and trismus exercises, tips and stories from former patients, what to expect each week of treatment, recipes and cooking demonstrations, how to take care of their teeth during treatment, strategies for stress relief, and strategies for dry mouth and nausea. this website is designed to reach underserved populations who do not have ready access to specialized preventive care. after completion of study, patients are followed up at 6 months.

Eligibility criteria:
inclusion criteria: * receiving radiation treatment with curative intent for throat cancer * can read and speak english or spanish well enough to answer our questionnaires and understand our website content.

Keywords: head and neck cancer swallowing trismus adherence coping rural website access
characterization and support of neurodevelopmental disorders associated with congenital cardiac malformations - neonatal

Conditions: Heart Disease Congenital; Neurodevelopmental Disorder

Summary: congenital heart defects (chd), as the leading cause of birth defects, affect 12 million people globally and approximately 41,000 newborns each year in europe. chd presents a significant public health concern due to its association with high morbidity and mortality rates across the lifespan. over 50% of infants born with critical chd will develop neurodevelopmental disorders (ndd), requiring specialized care and impacting their quality of life. ndds, involving early and persistent disruptions in cognitive, emotional, and behavioral development due to abnormal brain development, are highly variable. they may impact language, learning, motor skills, intellectual efficiency, social cognition, attention, memory, and executive functions, often accompanied by psychosocial difficulties. these hidden disabilities constitute the primary long-term sequelae of chd, surpassing even cardiovascular complications in impact, and affect children who often undergo multiple cardiac surgeries during early childhood. ndds are associated not only with complex chds but also with simpler chds that are repaired in early childhood and considered 'cured.' the origin of chd-associated ndds remains largely unknown. while few genetic or environmental causes have been identified, recent research suggests a possible common origin linking heart malformations and neurodevelopmental abnormalities. the catamaran neonatal cohort project aims to detect developmental delays associated with chd as early as six months of age and to identify both individual susceptibility factors and acquired vulnerabilities contributing to the development of ndds in infants with chd.


Eligibility criteria:
the inclusion criteria are as follows: * fetus with a congenital heart defect (chd) detected prenatally (prenatal diagnosis of the heart defect) * fetus with a critical chd defined as requiring cardiac surgery during the first three months of the infant's life * parents affiliated with or beneficiaries of a social security or equivalent system * parents' good understanding of the french language * voluntary, informed, and written consent from both parents for themselves and the unborn child criteria for parents\*: - biological parents \*the inclusion of the father in the project does not limit the participation of the child (patient) in the study. \*the father will be encouraged to participate in the project by providing a blood sample to create a trio (mother/father/infant) for future genetic analyses. however, if the father is unavailable or does not consent to the collection and storage of samples for analysis (as part of the catamaran study or future research projects related to biobanking), the child can still be included in the study. exclusion criteria: * medical termination of pregnancy considered * genetic anomaly or malformative syndrome identified prior to inclusion

Keywords: congenital heart defects (chd) neurodevelopmental disorders (ndd) genetics
pilot study, comparative, single-center, randomized, crossover, double-blind, against placebo, testing the effectiveness of triheptanoin oil in alternating hemiplegia of childhood

Conditions: Alternating Hemiplegia of Childhood

Summary: the purpose of this project is to study the efficacy of triheptanoin oil in patients with alternating hemiplegia of childhood (ahc) due to atp1a3 gene mutation.

the clinical spectrum of alternating hemiplegia of childhood (ahc) is wide and characterized by the association of permanent and paroxysmal (palsy, dystonia, ocular, epileptic, dysautonomic events) neurological events, with onset in childhood. most of ahc patients carry mutations in the atp1a3 gene. this gene encodes the na+/k+ atpase witch is a transmembrane ion pump generating chemical and electrical gradient of sodium and potassium across the plasma membrane. those paroxystic events in ahc patients with mutations in the atp1a3 gene could be associated with a glucidic/energetic metabolism or intracerebral excitability disorder. triheptanoin is a triglyceride, whose derivatives pass the blood - brain barrier and enhance the krebs cycle functions. triheptanoin could therefore allow energy supply to the brain, which is essential for the functioning of the na+/ k+ atpase that consumes a significant amount of energy in the brain. the investigators goal is to do a pilot study to test the effectiveness on paroxystic manifestations and the safety of triheptanoin in a small group of patients with alternating hemiplegia of childhood secondary to atp1a3 mutations.

Eligibility criteria:
inclusion criteria: * ahc with mutation in atp1a3 gene * age ≥ 15 years and 3 months * ≥ 6 neurological paroxystic events during the last 3 months prior to the beginning of the study * no specific diet * covered by french social security * patients who freely agree to participate in this study and understand the nature, risks and benefits of this study and give their written informed consent. (in addition to the requirement for the consent of parents or the legal representative, adolescents can provide additional informed consent to participate in clinical trials) exclusion criteria: * age \< 15 years and 3 months * evidence of psychiatric disorder * comorbid medical condition that would render them unsuitable for the study, e.g. hiv, diabetes * pregnant or parturient or lactating women * absence of double effective contraception at the women old enough to procreate * unwillingness to be informed in case of abnormal mri * absence of signed informed consent * no covered by french social security * persons deprived of their liberty by judicial or administrative decision * person subject to an exclusion period for another research * subjects with exclusion criteria required by french law