Kornimate/medical-research-clean huggingface dataset:
duchenne muscular dystrophy video assessment registry

Conditions: Duchenne Muscular Dystrophy

Summary: arise is a prospective and longitudinal clinical study of individuals with duchenne muscular dystrophy (dmd) aimed at creating a database of functional motor abilities in this population to support validation efforts of the duchenne video assessment (dva).

arise is a longitudinal, observational study of individuals with duchenne muscular dystrophy (dmd). the duchenne video assessment (dva) is a home-based clinical outcome assessment that measures ease of movement through identification of compensatory movement patterns. the dva directs caregivers to video record patients doing specific movement activities at home using a secure mobile application. in this study, participants will remotely complete the dva in addition to existing dmd functional assessments (north star ambulatory assessment (nsaa) and performance of upper limb (pul 2.0)) to evaluate the longitudinal measurement properties of the dva.

Eligibility criteria:
inclusion criteria: * at least 2 years of age at time of consent * written consent (english only) by adult participant or parent/legal guardian of minor participant * written assent (english only) if minor participant is at least 7 years of age * documentation provided for the participant's diagnosis of dmd (i.e., genetic report, clinic note) exclusion criteria: participants will be excluded if they are unable to use a hand to hold a pen, pick up pennies or drive a powerchair.

Keywords: duchenne dmd remote video assessment
impact of pre-operative bevacizumab on complications after resection of colorectal liver metastases

Conditions: Colorectal Liver Metastases

Summary: hypothesis of the study: neoadjuvant chemotherapy with bevacizumab impairs postoperative outcome after resection of colorectal liver metastases.

bevacizumab is a humanized monoclonal antibody against vascular endothelial growth factor (vegf) increasingly added to other drugs in the treatment of colorectal cancer. bev is typically used in combination with other chemotherapeutic agents such as oxaliplatin, irinotecan, leucovorin and 5-fluorouracil (5-fu) for treatment of patients with crlm. the objective of this study was to assess the impact of neoadjuvant bevacizumab on clinical outcome after hepatectomy of colorectal liver metastases (crlm). patients, who underwent liver resection due to colorectal liver metastases after neoadjuvant chemotherapy, operated between 2005 and 2007 will be evaluated retrospectively. the patients will be distributed in two groups, either with or without bevacicumab. outcome parameters are mortality, complications, hospital stay and icu stay. to increase the power of the study the total number of patients will be increased by adding patients from other centers. results will be adjusted for the propensity of developing complications.

Eligibility criteria:
inclusion criteria: * patients with neoadjuvant chemotherapy prior to liver resection exclusion criteria: * patients without neoadjuvant chemotherapy

Keywords: neoadjuvant chemotherapy bevacizumab
comparison study of isv-303 to durasite vehicle in cataract surgery subjects

Conditions: Ocular Inflammation

Summary: the purpose of this study is to evaluate the ocular safety, tolerability and efficacy of topical administration of isv-303 compared with durasite vehicle.


Eligibility criteria:
inclusion criteria: * male or female subjects age 18 or older scheduled for unilateral cataract surgery with posterior chamber intraocular lens implantation * if a female is of childbearing potential, the subject must agree to and submit a negative pregnancy test before any protocol-specific procedures are conducted. the subject must use effective contraception for the duration of the study. post menopausal is defined as having no menses for at least 12 consecutive months * signature of the subject on the informed consent form * willing to avoid disallowed medications for the duration of the study * willing and able to follow all instructions and attend all study visits * able to self-administer the imp (or have a caregiver available to instill all doses of study drugs ) * additional inclusion criteria also apply exclusion criteria: * known hypersensitivity or poor tolerance to bromfenac sodium or any component of the imp or any of the procedural medications * currently pregnant, nursing, or planning a pregnancy; or be a woman that has a positive pregnancy test * currently suffer from alcohol and/or drug abuse * prior (within 30 days of beginning study treatment) or anticipated concurrent use of an investigational drug or device * a condition or a situation, which in the investigator's opinion may put the subject at increased risk, confound study data, or interfere significantly with the subject's study participation * additional inclusion criteria also apply
prediction of cervical radiculopathy success with pnf and mobilization

Conditions: Cervical Radiculopathy

Summary: the goal of this predictive interventional study is todetrmine clinical predictors for success with combined proprioceptive neuromusclualr faciitaion (pnf) and passive mobilization ain patients with cervical radiculopathy (cr).

this study will answer the question, what are the factors affecting success with pnf and mobilization for patients with cr? no control group. the goal of this new study is to see the effect of age, duration of symptoms, forward posture angle and neck disability index response to passive mobilization combined with the pnf technique

Eligibility criteria:
inclusion criteria: * participants with cervical radiculopathy. * age ranges between 40 and 60 years old. * minimum score (3 out of 10-point) on a visual analog scale (vas) * orthopedic clinical confirmation reveals a history of neck pain. exclusion criteria: * whiplash injury. * previous cervical surgery. * pain less than three months. * mechanical and non-specific neck pain. * pregnancy. * bilateral arm pain. * inflammatory arthritides. * osteoporosis. * symptoms of vertebrobasilar insufficiency.
improving surgical outcomes in patients with low grade gliomas using advanced pre- and intra-operative mri

Conditions: Brain Neoplasms

Summary: this aim of this study is to improve the outcomes for patient with gliomas undergoing neurosurgery by maximising the extent of resection whilst minimising neurological morbidity. this will be achieved through the use of advanced mri, fmri and dti, performed at two stages of the patients' clinical management.

low grade gliomas are often located near to and infiltrate into important parts of brain which are involved with language and motor function. during surgery to remove these tumours, there is a fine balance between trying to remove as much of the tumour as possible and limiting any damage to these functionally important parts of the brain which, particularly in a young patient, may result in impairment for the rest of their life. functional mri (fmri) can be used to identify these functionally important cortical areas and diffusion tensor imaging (dti) can be used to identify the important subcortical and deep white matter tracts connecting these regions. the use of these advanced imaging techniques performed pre-operatively to plan surgery is now commonplace however their role in guiding the actual operation itself is limited because of the occurrence of 'brain shift', this being deformation in the contour of the brain parenchyma which occurs as the tumour is resected. this can result in inaccuracies if the pre-operative advanced mri data is being used in the neuronavigational system to guide surgery. the main aim of this study is to determine the optimal method of providing updated, spatially accurate data on the location of these functionally important areas of the brain to the neurosurgeon intra-operatively. in this study, two different techniques will be compared. the first is the acquisition of real-time fmri and dti acquired intra-operatively during tumour resection. the second is to use intra-operatively acquired structural and diffusion sequences to perform non-rigid co-registration of fmri and dti data which has been acquired before surgery. the feasibility and then the accuracy of these two techniques will be evaluated. the second aim of this study is to better understand the effect that the tumour and surgery have on language function as this will have important implications on the planning of the surgical approach, the counselling of patients of the possible risks of surgery and in helping to decide long term treatments. this will be achieved by performing advanced mri scans, in particular an extensive language fmri paradigm pre-operatively and post-operatively in patients with gliomas undergoing surgery. this will be combined with clinical testing of language function. greater understanding of the neural plasticity in this functionally important system could allow for a greater, maximal resection.

Eligibility criteria:
inclusion criteria: * intrinsic brain tumour requiring resection * aged 18 years or over exclusion criteria: * inability to give consent * contraindication to mri * no english language comprehension

Keywords: brain neoplasms magnetic resonance imaging neurosurgery
immune cells in inflammatory arthritis with coronaviruses, including covid-19

Conditions: SARS Virus

Summary: a team at the university of manchester are developing a test that tcould be helpful in detecting immunity to the coronavirus (which causes the covid-19 disease) in participants with inflammatory arthritis. it is based on a flu assay has already developed; the team will replace the flu antigen with a coronavirus antigen to see if it is effective. this project aims to develop a test to see if people who have had the virus have developed immunity to it. this could help to predict who might or might not get the disease a second time, who should stay at home to be protected from potential infection or who will not develop any symptoms, even if exposed to the virus. when vaccination trials against the coronavirus will be launched, this test could also help to see if the vaccine is effective.


Eligibility criteria:
inclusion criteria: * has previously taken part in either the braggss or national repository healthy volunteer study * has agreed to be contacted abut future research projects * has previously provided a blood sample for either the braggss or national repository healthy volunteer study * is willing to complete the informed consent form, registration slip, questionnaire and provide a 40ml blood sample * has a good written understanding of english exclusion criteria: * has not previously taken part in either the braggss or national repository healthy volunteer study * has not agreed to be contacted abut future research projects * has not previously provided a blood sample for either the braggss or national repository healthy volunteer study * is not willing to complete the informed consent form, registration slip, questionnaire and provide a 40ml blood sample * has not got a good written understanding of english
lutein supplementation in healthy children

Conditions: Eye Fatigue; Diet, Healthy; Cognitive Change

Summary: this is a single site, randomized, double-blind placebo controlled parallel arm study assessing the effects of 6 months lutein supplementation on cognitive and visual outcomes in healthy children exposed to excessive digital screen time.

studies in humans and primates have also shown that appropriate daily intake of lutein provides protection to the eyes from blue light from screen time devices such as computers, televisions and phones. it has been well-documented that children are spending far over the recommended two hours screen time per day and excessive exposure to the high energy blue light associated with digital devices has been shown to cause both short-term and long-term visual damage as well as disruption to the sleep cycle. with a globally aging population, if this deficit is not addressed adequately early on in life then there will be substantial public health consequences. a recent study predicted that if individuals were to consume the recommended levels of lutein and zeaxanthin daily, there would be a seven percent reduced risk for age related eye disease and a potential savings of over five billion us dollars annually.

Eligibility criteria:
inclusion criteria: * age of 8 to 16 years * guardian-reported general good health * guardian-reported 4 hours or more of digital screen time daily exclusion criteria: * currently using a supplement containing lutein or zeaxanthin

Keywords: lutein carotenoids blue light screen time digital stress
the effect of somatostatin for treatment of post hepatectomy liver failure (phlf)

Conditions: Liver Failure

Summary: post hepatectomy liver failure (phlf) is a serious medical problem could lead to patient death, however, definite treatment strategy has not been established. the liver is a regenerating organ and the possibility of phlf could be reduced when the appropriate liver regeneration is guaranteed. portal flow has known to be important during liver regeneration. low portal flow cannot induce proper regeneration, contrary, excessive flow increase shear stress in the hepatic sinusoid resulting liver failure. various medications has been used in malignant liver cirrhosis to reduce portal pressure. among them, somatostatin has been used modulating portal flow reducing portal and sinusoidal pressure. in this study, the investigators administrate somatostatin at a rate of 3.5ug/kg/hour to phlf patients (prothrombin time \ 2.9mg/dl after liver resection) until recovery from liver failure. for assessment of the recovery of liver failure, the investigators evaluate aspartate transaminase (ast), alanine transaminase (alt), serum total bilirubin and prothrombin time periodically after administration of medication.


Eligibility criteria:
inclusion criteria: 1. patients with phlf without regard primary disease. 2. ability to provide written informed consent exclusion criteria: 1. concomitant surgery for another intraabdominal organs. 2. severe renal disease requiring dialysis. 3. patients with coagulation disorders or taking warfarin. 4. immunosuppressed patients or the patients with autoimmune disorders. 5. women with pregnant, breast-feeding. 6. hypersensitivity to somatostatin. 7. patients treated with other investigational product within 30 days at the consents are obtained. 8. patients with a significantly reduced cognitive abilities. 9. not eligible to participate for study at the discretion of investigator.
a study to explore the influence of two opioid pain medications on bacterial composition in the gut and other gastrointestinal aspects

Conditions: Severe Chronic Pain

Summary: the study is intended to explore changes in the composition and quantity of gut bacteria subject to treatment with strong pain medication. two pain medications will be compared (oxn pr and oxypr). other gastrointestinal parameters will be assessed.

patients who require around-the-clock opioid therapy and show symptoms of constipation secondary to opioid treatment will be randomised to receive either oxn pr followed by oxypr, or vice versa. each treatment takes 24days. the study is composed of three phases, a pre-randomisation phase, a double-blind phase and a follow-up phase.

Eligibility criteria:
inclusion criteria: subjects who are receiving who step ii/iii opioid analgesic medication for the treatment of non-malignant pain and who require daily opioid treatment for pain with who step iii opioid therapy for the duration of the study, based on investigator's judgement. documented history of non-malignant pain that requires around-the-clock opioid therapy (20 - 50 mg oxycodone pr equivalent per day for a minimum of study duration). subjects with constipation caused or aggravated by opioids: * subject's medical need of regular intake of laxatives to have at least 3 bowel evacuations per week, or having less than 3 bowel evacuations when not taking a laxative. * in the opinion of the subject and investigator confirm that the subject's constipation is induced, or worsened by the subject's prestudy opioid medication (present at screening). exclusion criteria: any contraindication to oxycodone, naloxone, or any non-investigational medicinal products (nimps) that will be used by subjects during the study. continuous systemic use of antibiotics and/or steroids within the last 4 weeks prior to the start of the screening period and during the study period. chronic or intermittent pain that results from fibromyalgia or rheumatoid arthritis

Keywords: oxycodone naloxone combination severe chronic pain non-malignant pain non-malignant pain that requires around-the-clock opioid therapy
effectiveness of cbt and apt on managing child anxiety in dental office

Conditions: Dental Anxiety

Summary: this study was conducted to the effectiveness of cognitive behavioral therapy and auricular plaster therapy on managing child anxiety in dental office.

this study is to: 1. assess and compare the effect of cognitive behavioral therapy and auricular plaster therapy on children's anxiety in dental situations. 2. improve child behavior and cooperation and evaluate the parental acceptance of these behavioral management techniques.

Eligibility criteria:
inclusion criteria: 1. healthy children (4-7) years old, without systemic, congenital, or mental disorders nor deformities affecting the external auditory meatus. 2. presence of dental anxiety. 3. not requiring urgent dental treatment, with the presence of a class i carious lesion on one of the primary molars. 4. no previous application of the guided cbt. exclusion criteria: 1. refusal to participate by either the children or their parents/guardians 2. previous receiving acupuncture and moxibustion therapy. 3. children who had taken sedative drugs at the time of the appointment.

Keywords: dental anxiety (da) cognitive behavioral therapy (cbt) auricular plaster therapy (apt) tell show do (tsd)
t cell response in hypersensitivity syndrome

Conditions: Hypersensitivity; Syndrome

Summary: immunological study of the t cell repertoire phenotype and functionality in hypersensitivity syndrome.


Eligibility criteria:
inclusion criteria: * age \> 18 * cutaneous eruption * lymph nodes * hepatitis * interstitial pneumonia * nephritis * cardiopathy * eosinophilia * hyperlymphocytosis exclusion criteria: * age minor to 18 * hiv +
a study on children with covid-19 admitted at assiut university children hospital

Conditions: COVID-19

Summary: the aim of study is to: 1-describe demographic and clinical data of children infected with covid-19 admitted at isolation unit of assiut university children hospital 2- assess the risk factors responsible for complications of covid-19 in children 3-assess the outcome of covid-19 in children admitted at auch.

in december 2019, reports emerged of a cluster of cases of pneumonia of unknown cause in wuhan, china, culminating in the identification of a novel coronavirus on 12 january 2020, denoted as severe acute respiratory syndrome coronavirus 2 (sarscov-2), and the associated disease as coronavirus disease 2019 (covid-19) (1). some cases of infection in children have also been reported (2) the symptoms of pediatric covid-19 are mild, the decrease in lymphocytes is not obvious and severe cases are rare. initially, children comprised between 1% and 2% of the laboratory-confirmed sarscov-2 detections among people in china (3), italy (4), and the united states (5). initial reports from (cdc) noted the following age distributions: 15-17 years (32%), 10-14 years (27%), 5-9 years (15%), 1-4 years (11%), and \<1 year (15%), with a median age of 11 years (5). diagnosis of covid-19 will depend on the clinical presentation of the case and on laboratory test as well as radiological finding. the cases will be stratified according to these collective data to different grades of severity (6). investigations for suspected case: cbc and radiology, to confirm diagnosis: nasopharyngeal swab for pcr and to assess severity: serum ferritin, d dimer, ldh, and crp. (7) current treatment for covid-19 is mainly supportive care (8).the decision of the site of management either at home or in hospital depends on the clinical presentation, requirement for supportive care, potential risk factors for severe disease, and the ability of the patient to self-isolate at home(9) (10).

Eligibility criteria:
inclusion criteria: * all children (up to 18 years) diagnosed with covid-19 admitted at isolaton unit of assiut university children hospital through the period from 1st january 2021 to 31st december 2022 exclusion criteria: * clinically suspected patients approved by ct chest and pcr not infected with covid-19.

Keywords: children covid-19
purge vs no purge in living donor liver transplantation recipients

Conditions: Ischemia Reperfusion Injury

Summary: the investigators tested the impact of purging the graft contents and mesenteric blood into the systemic circulation versus washing out this volume out of the circulation in living donor liver transplantation recipients.

all donors had right hepatectomy. on the back table, surgeons flushed liver grafts with 4 liters of cold custodiol solution. patients were randomized into either purge group (pg) (n=40) were graft fluid contents were washed out by the patient's portal vein blood (0.5ml per gram graft weight) through incompletely anastomosed hepatic vein, or no purge group (npg) (n=40) where graft fluid contents were washed into the systemic circulation by the patient's portal blood. the primary outcome objective was the mean arterial blood pressure 5 minutes after portal declamping. secondary objectives included hemodynamic and oxygenation.

Eligibility criteria:
inclusion criteria: * adult living donor liver transplantation recipients of either sex in mansoura liver transplantation program exclusion criteria: * re-transplantation * previous upper abdominal operation * budd chiari syndrome

Keywords: liver transplantation graft rinse ischemia reperfusion injury
an exploratory investigation of a male focused skincare supplement

Conditions: Acne; Skin Abnormalities

Summary: most skincare products on the market are topical and do not take a holistic approach to understanding skin health. this trial will examine a dietary supplement designed to support the gut microbiome and promote skin health from an internal perspective. research has previously supported the link between the gut microbiome and skin health and the supplement tested in this trial will further the knowledge on the effectiveness of supporting gut health to improve skin outcomes.


Eligibility criteria:
inclusion criteria: * male * between the ages of 18-55 * frequently experience different forms of acne * frequently experience breakouts * must be in good health with no long term health conditions * bmi must be under 40 * must follow a consistent dietary regimen * must be willing to stop any oral supplementation targeting their skin while in the trail exclusion criteria: * anyone who does take prescription medication (oral or topical) targeting their skin including reinoid, over the counter retinol, or retinal * not willing to stop any oral supplementation targeting their skin * severe chronic conditions, including oncological and psychiatric disorders * previous severe allergic reactions * unwilling the follow the study protocol
test-retest reliability of myocene

Conditions: Reliability; Fatigue

Summary: the test retest reliability of myocene will be tested.


Eligibility criteria:
inclusion criteria: * active individuals exclusion criteria: * injured participants * unhealthy volunteers