Kornimate/medical-research-clean huggingface dataset:
inotropic treatment with levosimendan (simdaxr)in heart surgery

Conditions: Heart Failure; Cardiac Surgery

Summary: hypothesis: treatment with levosimendan will preserve myocardial function and hemodynamics after cardiac surgery and lead to reduced stay at intensive care unit

single center, prospective, randomized parallel-group, double-blinded study

Eligibility criteria:
inclusion criteria: * ef (ejection fraction)\<40% exclusion criteria: * renal failure, liver failure

Keywords: coronary artery disease, aortic stenosis, heart failure
nasal decolonization for orthopedic trauma patients

Conditions: Surgical Site Infection

Summary: many surgical site infections are caused by bacteria that is transferred from a patient's nose to their open surgical wound. some small studies have shown that putting povidone-iodine in a patient's nose reduces this risk. this study aims to evaluate the real-world effectiveness of nasal povidone-iodine (profend®) in a group of 50 patients at the university of iowa.

aim 1. evaluate the real-world effectiveness of intranasal povidone-iodine (profend®) in reducing staphylococcus aureus colonization and surgical site infections (ssis). aim 1a. evaluate patients after surgery to determine s. aureus colonization and to survey patients on tolerability of intranasal povidone-iodine decolonization. the intranasal povidone-iodine swab will be administered to the patient's nares around one hour prior to the first surgical incision. it will then be re-applied around 12 hours later, for a total of two applications within a 24 hour period. during the same visit at 24 hours after surgery, patients will also be administered a questionnaire to determine the tolerability of intranasal povidone-iodine decolonization. questions will be asked about adverse events (e.g., itching, irritation) and how intranasal povidone-iodine felt (very pleasant, pleasant, neutral, unpleasant, very unpleasant). based on the data obtained from this aim, we will summarize the patient acceptance of intranasal povidone-iodine. aim 1b. compare the rates of ssi among orthopaedic trauma surgery patients who received intranasal povidone-iodine to similar patients who received orthopedic trauma surgery before intranasal povidone-iodine implementation.

Eligibility criteria:
inclusion criteria: * patients undergoing operative fixation of lower extremity fractures at the university of iowa during the study period. exclusion criteria: * patients unable to provide informed consent due to head trauma or dementia.

Keywords: nasal decolonization orthopedic trauma surgery
effect of myofascial release technique on reducing symptoms in patients with chronic disc protrusion

Conditions: Low Back Pain

Summary: the purpose of this study is to determine whether myofascial release technique are effective in the treatment of low back pain due to lumbar disc herniation.


Eligibility criteria:
inclusion criteria: * lumbar disc herniation * muscular trriger points * independent ambulated patients exclusion criteria: * neoplasm * lumbar surgery history * fracture * inflammatory disease
polymorphism of beta2-adrenoceptor and regular use of formoterol in asthma

Conditions: Asthma

Summary: polymorphism at codon 16 of the beta2-adrenoceptor (beta2-ar) affects the responsiveness to salmeterol in asthmatics. data concerning formoterol are more controversial in literature. the aim of this study was to verify whether homozygote for arginine-16 (argarg16) and homozygote for glycine-16 (glygly16) genotypes differently influence the long-term responsiveness to formoterol.


Eligibility criteria:
inclusion criteria: * mild to moderate asthma * stable clinical conditions exclusion criteria: * smokers * current therapy with oral steroids * exacerbations within the past 3 months
healing hearts together: evaluating a couples-based intervention to improve health outcomes

Conditions: Cardiovascular Diseases

Summary: the purpose of this study is to test the efficacy of the 8-week healing hearts together (hht) program to improve relationship quality, mental health, quality of life (qol), and cardiovascular health. this is a randomized controlled trial in which couples are randomly assigned to the hht group or usual care. changes in the outcomes of interest will be assessed at the end of the intervention (8 weeks) and 6 months later.


Eligibility criteria:
inclusion criteria: 1. university of ottawa heart institute (uohi) patients and their partners 2. participants in a romantic relationship who are cohabiting (married, common-law or committed relationship for ≥1 year). no restrictions will be placed on sexual orientation. 3. participants are ≥ 18 years of age 4. participants are able to read and understand english (hht materials are only available in english; once efficacy has been established, all materials will be translated to french). 5. patients and partners are available to participate for the next 6 months (intervention and follow-up). 6. patients and partners are able to provide informed consent. exclusion criteria: 1. participants who, in the opinion of the study psychologist, manifest psychiatric illness or cognitive impairment that would preclude participation in hht (i.e. unable to benefit from the intervention; to prevent disruption of other participants). 2. participants who are engaging in couples therapy or plan to engage in couples therapy in the next 6 months.

Keywords: couple relationship heart disease
aerobic exercise intervention for knee osteoarthritis

Conditions: Osteoarthritis

Summary: this trial will test if walking or bicycling exercise is effective as a non-surgical treatment option for patients with knee osteoarthritis.

traditional, conservative medical treatment of osteoarthritis has been directed at improving functional status through reducing joint pain and inflammation and maintaining or restoring joint function. exercise is an adjunct therapy in the clinical management of patients with osteoarthritis of the knee. however, it is not uniformly accepted. the central hypothesis of this work is that the surgeon general's exercise guidelines can be successfully implemented as an effective nonsurgical option for treatment of patients with early stages of knee osteoarthritis. patients with knee osteoarthritis will be randomized into a control group, a walking exercise group, and a stationary cycling exercise group. the individuals in the exercise groups will be required to exercise three times per week for one year using emerging public health recommendations for aerobic exercise in the adult and aging population. patient outcome will be assessed using objective gait analysis measurements, knee radiographs to quantify joint space narrowing, magnetic resonance imaging, a general health questionnaire (sf-36), a disease/site specific questionnaire (womac), and a visual-analog pain scale. all subjects will be studied at 0 and 52 weeks.

Eligibility criteria:
inclusion criteria * current symptoms of chronic (6 months), stable pain and/or stiffness in one or both knees during weight-bearing activities * involved joint is primary factor limiting physical or functional activity * radiographic signs of mild or moderate arthritis * mild joint space narrowing (at least 2mm remaining) exclusion criteria * current participation in a regular exercise program * existing medical condition that would preclude increased physical activity * subjective complaint of instability (giving way) * ligamentous instability greater than grade i * knee flexion contracture greater than 15 degrees * asymptomatic osteoarthritis of both knees, incapacitating arthritis, or inflammatory arthritis * major reconstructive surgery on a lower extremity joint * multiple major joint involvement * any condition which severely limits local ambulation, such as amputation or stroke * gait aids used majority of time for ambulation * cannot use step-over-step techniques in either ascending or descending stair conditions * not able to undergo mri scan (e.g., cardiac pacemaker) * dementia or inability to give informed consent as determined by a folstein mini mental score greater than 24

Keywords: knee aerobic exercise walking cycling gait mri
the rate of space closure with piezocision-based corticotomy in different facial types: a split-mouth design

Conditions: Class II Div 1 Malocclusion

Summary: 23 female participants with class ii div i will have extraction of bilateral first bicuspids 10 weeks after bond- up appointment. the extracted teeth will be preserved in special containers for subsequent microscopic analysis. four months later, upon space closure phase, the patient will have a piezocision surgery on one side randomly chosen. virtual models will be generated once before the surgery and monthly after for four and a half months. the models will be scanned by cadcam and later tooth movement will be analyzed in regards to the rugae area.


Eligibility criteria:
inclusion criteria: * young adults and adults (15-29). * middleastern caucasian. * females. * having the defined orthodontic appliance, slot size, prescription, and technique of space closure. * class ii division i of moderate space requirement that is planned to have the first premolar extracted. * average or high facial type. * healthy patients without systematic diseases that could affect bone and tooth movement and no contraindication (medical or psychological) to avoid oral surgery. * no active periodontal diseases as this effect the cytokines expression (stabilized prostaglandin (pg) health) * good oral hygiene. * no other method of non-surgical acceleration technique to be used. exclusion criteria: * patients who refused to consent for the study. * the two extremes of age (younger than 14 and older than 29). * having other than the defined orthodontic appliance, slot size, prescription, and technique of space closure. * extraction cases of high space requirements or other teeth than the first premolar. * patients with systematic diseases that could affect bone and tooth movement and no contraindication (medical or psychological) avoid oral surgery. * active periodontal diseases. * other methods of non-surgical acceleration technique to be used.

Keywords: canine retraction space closure rate of tooth movement facial divergence piezocision
acupuncture for people experiencing period loss due to chemotherapy

Conditions: Cancer; Period Problem

Summary: the purpose of this study is to find out whether it is practical (feasible) to use acupuncture to treat period loss (amenorrhea) caused by chemotherapy treatment in people with cancer. the researchers will look at how many participants enroll and complete the study. the researchers will also study how treatment with acupuncture affects the amount of time for the menstrual cycle to return and symptoms and quality of life related to amenorrhea.


Eligibility criteria:
inclusion criteria: * english speaking women under the age of 40, with a history of stage i, ii, or iii cancer at the age of 18-39 * premenopausal status with regular menstruation at the time of diagnosis by patient report * completed chemotherapy within the past year * report cessation of menses during or after chemotherapy and have not experienced menses recovery at the time of enrollment. * have been without menses for at least 3 months following the completion of chemotherapy * willing to adhere to all study-related procedures, including randomization to one of the two possible arms: acupuncture and wlc exclusion criteria: * metastatic cancer (stage iv) * had been pregnant or lactating within 3 months prior to enrollment * history of hysterectomy or oophorectomy * ongoing or planned radiation or surgery within 4 months from randomization * use of acupuncture for menses recovery within 3 months of enrollment * had been or will be receiving ovarian suppression medicine, such as leuprolide (lupron) and goserelin (zoladex), or hormonal contraception drugs within 3 months of enrollment or during the study period

Keywords: acupuncture stage i cancer stage ii cancer stage iii cancer period loss due to chemotherapy
personalized cellular vaccine for glioblastoma (percellvac)

Conditions: Glioblastoma

Summary: dendritic cell-based cellular vaccine for tumor therapy has shown efficacy. this study is designed to perform a personalized clinical trial by first analyzing the expression of tumor associated antigens in patients with newly diagnosed glioblastoma and then immunizing the patients with personalized dc-based cellular vaccine. immune responses to tumor antigens will be monitored. safety and efficacy will be observed in the study.

this is an open label, single-arm, single-institution, phase i study designed to investigate the safety and efficacy of personalized cellular tumor vaccine for patients with newly diagnosed glioblastoma (gbm). newly diagnosed gbm patients will undergo tumor resection. the tumors will be analyzed for the expression of a panel of glioma-associated antigens and immune-related genes. post surgical treatment will be 6 weeks standard chemotherapy with temozolomide and concurrent radiotherapy and continue cycles of temozolomide within a 28-day window. patients will undergo leukapheresis either after surgery or after concurrent radio/chemotherapy. based on individual tumor antigen expression, in vitro transcribed mrna will be generated and used to pulse in vitro generated dcs. the patients will be immunized i.d. and i.v. biweekly with dc cellular vaccines. safety and efficacy will be monitored. the primary objective is to assess the safety of the personalized cellular vaccines. the secondary objective is to assess the specific t cell response to immunized vaccines. in addition, the antitumor efficacy of the vaccines will be measured using irano criteria, progression-free survival and overall survival.

Eligibility criteria:
inclusion criteria: * newly diagnosed glioblastoma grade iv * patients at the age of 18-65. * patients must have undergone maximal surgical resection of the tumor. * patients with karnofsky scores \> or =70 * patients with normal range of hematologic and metabolic test results. * patients must have no corticosteroids treatment at least one week before vaccination. * patients capable of understanding the study and signed informed consent. exclusion criteria: * breast feeding females. * pregnant women. * infectious diseases hiv, hbv, hcv * documented immunodeficiency * documented autoimmune disease * any serious or uncontrolled medical or psychiatric conditions, for example, severe pulmonary, cardiac or other systemic disease. * patient inability to participate as determined by pi discretion.

Keywords: glioblastoma dc vaccine tumor antigen personalized vaccine
mapping draining lymph nodes in cns malignancies

Conditions: Central Nervous System Neoplasms; Central Nervous System Tumor

Summary: the purpose of this research study is to determine whether the lymph nodes that drain a brain tumor can be detected by imaging after injection of a substance called tc-99m tilmanocept directly into the brain tissue around the tumor. tc-99m tilmanocept is a radioactive substance that is used to find lymph nodes by injecting it and then scanning the body with a device that can trace its radioactivity. in this study, the investigators are looking to see how long it takes the tc-99m tilmanocept to travel from the tumor to the lymph nodes. the investigators will be using it to map lymph nodes as they relate to specific brain areas.


Eligibility criteria:
inclusion criteria: * candidate for surgical resection or stereotactic biopsy of suspected brain tumor, including benign tumors (e.g., meningioma) and malignant tumors (e.g., glioma or metastatic disease). * suitable candidate to receive tc-99m tilmanocept injection and study related imaging post-operatively per the principal investigator and/or treating neurosurgeon. * at least 18 years of age. * willing and able to provide informed consent (or consent of legally authorized representative). exclusion criteria: * documented hypersensitivity to dextran and/or modified forms of dextran. * pregnant. * prior surgical evacuation of lymph nodes of the head and/or neck
reflexology and mulligan mobilization for knee osteoarthritis

Conditions: Knee Osteoarthritis; Knee Osteoarthritis (Knee OA)

Summary: to investigate the effect of adding reflexlogy to mulligan mobilization and the conventional treatment for patients with osteoarthritis knees

knee osteoarthritis (oa), also known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage. treatment by reflexology stimulation increases blood flow to the associated organ or body part. on the other hand, the nerve impulse theory claims that reflexology stimulation boosts nervous connection to the conforming body parts. regarding to the energy theory; organs and body parts are connected through electromagnetic fields and that these pathways are blocked in states of disease. finally, lactic acid theory pointed that lactic acid accumulates on the soles of the feet in the form of crystals which promotes free circulation, so reduces regular flow .the effects of foot reflexology on improving physical complains of koa. therefore, this study was conducted to evaluate the effectiveness of reflexology foot massage on pain intensity and physical functional abilities among patients with knee osteoarthritis. mulligan's mobilization with movement (mwm) advocates therapist-applied accessory gliding force combined with active movement the goal of mwm is to achieve immediate pain relief possibly by regulation of the non-opioid pain sensory pathways and by correction of micro positional faults. these positional faults may result from changes in the shape of articular surfaces, cartilage thickness, fiber orientation in the capsule-ligamentous complex, and the direction of musculo-tendinous pull, causing altered mechanics in the osteoarthritic knees.

Eligibility criteria:
inclusion criteria: 1. age greater than or equal to 40 years. 2. body mass index ≤30 kg/m². 3. all participants have calcium deficiency 4. osteoarthritis in mild and moderate stage not in the acute stage 5. the subjects were chosen from both genders exclusion criteria: 1. deep vein thrombosis 2. fractures 3. gangrena patient 4. osteopenic patient 5. lactating or pregnant women 6. cancer 7. neurological conditions. 8. patients with injury including; (lesions, sprain, open wounds, foot ulcer and or burn of the lower extremities), hemorrhage, epilepsy, irregular heartbeat. 9. vascular (anticoagulant therapy, aortic aneurysm) 10. neurological deficits (multilevel pivd, cervical myelopathy) 11. psychological disorders. -

Keywords: knee osteoarthristis reflexology mulligan&amp;#39;s mobilization
efficacy of ozurdex® in the treatment of diabetic macular edema (dme)

Conditions: Diabetic Macular Edema

Summary: this study will evaluate the efficacy of ozurdex® as prescribed in clinical practice in france for the treatment of diabetic macular edema (dme).


Eligibility criteria:
inclusion criteria: -patient with diabetic macular edema (dme) treated with ozurdex® in clinical practice. exclusion criteria: -patient not residing in metropolitan france.
the effect of intravenous versus volatile anesthesia on postoperative cognitive dysfunction in elderly patients

Conditions: Postoperative Cognitive Dysfunction

Summary: the goal of this clinical trial is to compare the permeability of blood-brain barrier between the intravenous anesthesia group and the inhalation gas anesthesia group in the elderly patients undergoing surgery. the main questions it aims to answer are: * \[is the permeability of blood-brain barrier between the intravenous anesthesia group and the inhalation gas anesthesia group in the elderly patients different?\] * \[is the incidence of postoperative cognitive dysfunction between the intravenous anesthesia group and the inhalation gas anesthesia group different?\] participants will be anesthetized with different categories of anesthetics. * intravenous anesthetics * inhalation gas anesthetics

this clinical trial targets patients aged 60 years or older with american society of anesthesiologists physical status (asa) 1 to 3 who undergo surgery under general anesthesia at our hospital. before entering the operating room, patients are randomly assigned to the intravenous anesthesia group and the inhalation gas anesthesia group. the intravenous anesthesia group uses propofol for anesthesia, and the inhalation gas anesthesia group uses sevoflurane. a 3 ml blood sample is collected four times: before surgery, at the end of surgery, 4 hours after surgery, and 1st day after surgery. all blood samples will be immediately transferred to the department of laboratory medicine and stored at -80 degree. pre-scheduled tests to determine the brain-blood barrier permeability and inflammatory cytokines will be conducted after the recruitment of all samples. in addition, for patients scheduled to be transferred to the intensive care unit (icu) after surgery among the study subjects, a 3 ml of cerebrospinal fluid sample is collected two times: before surgery, and at the end of surgery. the same preservation protocol will be applied to the cerebrospinal fluid samples. all study subjects will be monitored for postoperative delirium daily for up to 7 days after surgery or until discharge. cognitive function is assessed using telephone version of the montreal cognitive assessment (t-moca) before surgery and 3 months after surgery.

Eligibility criteria:
inclusion criteria: * age equal to or older than 60 * american society of anesthesiologists (asa) grade i to iii * general anesthesia longer than 2 hours exclusion criteria: * history of dementia * history of schizophrenia, epilepsy, or parkinson's disease * history of stroke or craniectomy * patient denial

Keywords: total intravenous anesthesia inhaled gas anesthesia blood-brain barrier permeability neuroinflammation delirium postoperative cognitive dysfunction
effectiveness of fascial manipulation in rotator's cuff surgery patients

Conditions: Cuff Rotator Syndrome

Summary: the purpose is to evaluate the effectiveness of fascial manipulation treatment in terms to reduce pain and improve physical functionality after rotator's cuff surgery. the technique involves deep friction manipulation of fascia's specific spots. distant from surgical site.

to evaluate the effectiveness of fascial manipulation treatment associated with standard physiotherapies treatment in rotator's cuff surgery patients, we'll randomize about 60 patients for arm's of study. both arm's will receive 10 standard physiotherapies treatments in 2 weeks while the experimental arm will receive 3 manual intervention on deep fascial tissues, according to fascial manipulation technique, providing a specific motor and manual assessment, and a deep manual intervention over specific fascial alteration. to evaluate the effectiveness of fascial manipulation treatment we'll use 2 type of outcome measure and we will compare the result of both arms of study.

Eligibility criteria:
inclusion criteria: * rotator's cuff surgery patients that have been operated within the past 4/5 weeks * age between 18 to 65 years old exclusion criteria: * patients with traumatic shoulder's injury that involved bone's fractures. * severe underlying pathologies like rheumatic, neurological and cardio pathologies that affect the correct shoulder treatment * patients on anticoagulant treatment