Kornimate/medical-research-clean huggingface dataset:
outcome and prognostic factors of surgical management of scalp avms.

Conditions: Cirsoid Aneurysm

Summary: scalp arteriovenous malformations (avms) are rarely encountered vascular scalp anomalies that represent 8% of all avms. different terms are being used to describe the vascular anomalies of the scalp include cirsoid aneurysm, racemosum aneurysm, plexiform angioma, arteriovenous fistula and arteriovenous malformation. derived from the greek language, kirsos, the term cirsoid aneurysm is used to describe the avm as it resembles varix. case studies reported approximately 200 cases with increased prevalence during the last 15 years. the etiology of scalp avms remains controversial, it can be spontaneous or traumatic. they generally develop in the trauma background and in patients over 30-year-old while spontaneous scalp avm may present at birth and remains asymptomatic until adulthood.

patients with scalp avms are usually presented with scalp swelling, and cosmetic concerns along with other presentations including headache, pain, tinnitus, audible bruits, palpable thrills, and hemorrhage. neuro-radiological diagnosis is the cornerstone for the surgical procedure to be performed, and cranial angiography is of great significance for diagnosis and treatment selection. mra is also of significance for establishing a diagnosis as scalp avms are confused with hemangioma and cavernomas. treatment of the cirsoid aneurysm is difficult due to the abnormal fistulous communications between the feeding arteries and veins and high shunt flow. management protocols for scalp avms include various options including surgical excision, endovascular embolization, ligation, and intralesional injections. operative blood loss, postoperative cosmetic complications are significant concerns when treating scalp avms, thus various methods are used pre and postoperatively in order to control these concerns. a thorough analysis of scalp avms regarding anatomy, feeder vessels, size, and other different variables is required for a better understanding of the problem in order to improve the outcomes.

Eligibility criteria:
inclusion criteria: * patients with scalp avms confirmed by various imaging techniques. avms of the scalp will include: cirsoid aneurysm, serpentinum aneurysm, racemosum aneurysm, plexiform angioma, arteriovenous fistula, high flow shunts and arteriovenous malformations. * age group: any age group. * aetiology: congenital, traumatic, or any. exclusion criteria: * high risk patients or unfit for surgery. * patients refused surgery, or scheduled for endovascular intervention.
new prognostic and predictive biomarkers for hpv-associated oropharyngeal cancer

Conditions: PREDICTIVE BIOMARKERS; Evaluation of HPV-specific E5 Transcript Expression in a Cohort of Patients With HPV-associated OPC; HPV 16 Positive Oropharyngeal Tumors (OPC)

Summary: the study involves the coexistence of a retrospective part, in which a group of patients with hpv-associated opc for whom follow-up data of at least 2 years after diagnosis are available, designed in order to evaluate the expression of hpv16-specific e5 transcript as well as that of pegfr and hla, and a multicenter prospective part, involving the enrollment of a control group, enrolled at the ent outpatient clinic of the ire and the outpatient clinics of the relevant lilt provincial committees, to better elucidate the role of hpv16-e5 in identifying potentially transforming infections due to the presence of hpv.


Eligibility criteria:
inclusion criteria: * male subjects * age \> 18 years * current and/or former smokers * reporting at least 5 (souza 2017) lifetime oral sex partners * written informed consent exclusion criteria: * oral pathology * inability to understand and sign an informed consent form

Keywords: hpv 16 oropharyngeal tumors (opc)
the prediction model of elderly patients in taiwan triage and acuity scale

Conditions: Frail Elderly Syndrome; Triage

Summary: in the year of 2010, the taiwan ministry of health and welfare had implemented the 5-level taiwan triage and acuity scale(ttas) in taiwan emergency department. ttas is a triage system that was modified from ctas. it has a comprehensive chief complaint system and accomplished with an electronic decision support system (ettas) to help triage nurse to assign acuity level on emergency patients in emergency departments of taiwan. ttas has adult and children modifiers, but no modifier for the elderly. in emergency departments, the geriatric population have been increasing in many countries for the last few years. they often present with atypical symptoms or signs, and multiple comorbidities that complicate diagnosis and treatment and are at risk of under-triage. although the ttas has overall validity and reliability, its performance in geriatric patients has not been well studied. in order to reduce the chance to under-triage the geriatric patients in emergency departments and to improve the discriminatory and predictive power for triaged patients who require admission, the objective of the study is to examine the difference of urgency, admission rate and medical resource consumption of geriatric patients with different age group compared to non-geriatric patients, to develop predictive model for hospitalization and medical resource consumption among geriatric patients and to develop special geriatric modifiers.

age and frailty have been demonstrated to be associated with clinical outcomes in the elderly presented to emergent departments (eds). this study aimed to assess the association of age and frailty on admission rate and to find out whether the current taiwan triage and acuity scale (ttas) under-triage elderly presented to eds. this was a retrospective cohort study that reviewed medical records of adult patients from a single ed from 2016 to 2017. data collected included patients' demographics, ttas level, chief complaints, frailty status, and intensive care unit (icu) admission rate. adults patients included in the study were divided into three age groups of 18-\ 85 years.

Eligibility criteria:
inclusion criteria: * patients over 65 years old who go to the emergency department. * those who are willing to participate in the trial and sign a consent form and are willing to be tracked. exclusion criteria: * patients under 65 years old who go to the emergency department. * patients over 65 years old who go to the emergency department, unwilling to participate in the trial and sign the consent.

Keywords: triage frailty geriatric
the effect of follicular flushing on oocyte retrieval rate and embryo quality

Conditions: Infertility

Summary: researchers will investigate the effect of flushing according to follicle size on the success of obtaining oocytes from a single follicle. in addition, by comparing the morphological quality of embryos developed from oocytes obtained with and without flushing, the possible effects of flushing on developing embryo quality will be investigated. by evaluating only one follicle for each patient, it is planned to investigate the effectiveness of the flushing process according to individual follicle characteristics, with a study design that has not yet been included in the literature.

prior to the oocyte pick up (opu) procedure, the dimensions (height x width x depth) of the first accessible follicle in any ovary will be recorded in millimeters. in this regard, any follicle larger than 12 mm will be selected for the first aspiration. it is planned to evaluate the effectiveness of the washing process in follicles with different sizes by performing the first aspiration procedure regardless of the follicle size. after aspiration of all the follicle fluid with a double lumen needle (17 gauge), the remaining fluid in the needle and line will be aspirated by giving 2 cc "flushing medium" to the follicle. in this way, all of the pure follicle fluid will be delivered to the in vitro fertilization (ivf) laboratory with the opu tube for initial evaluation. after the evaluation, if no cumulus oocyte complex (coc) is observed in the first sample, the washing process will be started. in this regard, flushing and aspiration will be performed respectively by giving 2 cc "flushing medium" to the same follicle 3 times. a total of 6 cc flushing medium obtained after the flushing-aspiration process will be delivered to the ivf laboratory and the presence of coc in it will be investigated again under the microscope. depending on the retrieval of oocyte by direct aspiration or flushing, each oocyte will be followed individually and its quality will be evaluated in case of embryo development from this oocyte.

Eligibility criteria:
inclusion criteria: * between 18-43 years old * patients who will undergo icsi procedure exclusion criteria: * patients who will undergo oocyte cryopreservation * patients with "empty follicle syndrome" in a previous opu procedure * cases that opu cannot be performed due to premature ovulation

Keywords: oocyte pick up oocyte retrieval follicle flushing
outcomes of full pulpotomy treatment in teeth with symptoms of irreversible pulpitis

Conditions: Pulpitis - Irreversible

Summary: the aim of this clinical trial is to learn how successful biodentine and neoputty dental filling materials are in treating dental pulp inflammation in adults. it will also provide information about post-treatment pain. the main questions it aims to answer are: do biodentine and neoputty dental filling materials treat dental pulpitis in participants? do they reduce the need for root canal treatment? after the application of biodentine and neoputty dental filling materials to the participants, the pain and symptoms that cause pain may not decrease. in this case, the tooth may be treated with root canal treatment. the researchers will compare the clinical success of biodentine and neoputty dental filling materials with each other. participants will undergo a single-session pulpotomy treatment with the dental filling materials mentioned above. clinical and radiographic follow-ups will then be performed at 3, 6 and 12 months, and records will be kept.


Eligibility criteria:
inclusion criteria: * • patient age must be between 18-50 years * must be able to give written informed consent * must have systemic status (asa 1) * must have mature permanent molar or premolar (lower upper) * must be symptomatic (spontaneous pain - mild to severe), extremely deep (d4) carious teeth * must have pulp exposure in non-selective carious cleaning procedure * must have vital response in cold test and electric pulp test * must have no periodontal disease * must have restorable teeth * must have teeth without pulp necrosis, sinus tract or swelling/abscess * must have bleeding time less than 10 minutes * maximum two teeth in a patient must be included in the study (must be in different quadrants and must have at least 2 weeks between treatment periods) exclusion criteria: * teeth with incomplete root development * teeth without symptoms of irreversible pulpitis * severely affected teeth that do not respond to pulp sensitivity tests * teeth without signs of bleeding after exposure with the pulp chamber * teeth with pulp chamber open to the oral environment * teeth with periodontal pockets greater than 4 mm deep * teeth with suspected cracks or crown fractures that may be responsible for pulp pathology * teeth with uncontrolled bleeding * medically risky patients will be excluded from the study.

Keywords: irreversible pulpitis calcium silicate-based cement total pulpotomy
cardiovascular health assessment of preterm- and term-born children

Conditions: Premature Birth

Summary: the purpose of the chapter study is to help understand how complications during pregnancy, such as preterm birth, affect how childrens' hearts and blood vessels develop.

young adults born preterm (less than 37 weeks gestation) have alterations in the structure and function of the heart, with similar changes observed in preterm infants in the first three months of life. it is unknown whether these early changes in the heart seen in the first few months of life are relevant to long-term changes in heart structure and function. heart changes have also not been well studied in children born preterm. to investigate this, the study will follow up children from the epoch study and will perform two study visits for each child (n=100 preterm and n=100 term) that will use echocardiography and cardiovascular magnetic resonance. individuals in the epoch study had echocardiography measures done at birth and three months postnatal age. it will therefore be possible to do longitudinal echocardiography measures from birth up to ages 12 years to determine whether postnatal heart changes in preterm infants track into childhood. cardiovascular magnetic resonance will allow for the determination of whether these early heart changes influence heart pump function. finally, by measuring lung function, blood vessel structure and function, and blood pressure, it will be possible to determine how heart changes relate to other components of the cardiovascular system. this data will be used to confirm the relevance of early heart remodelling in preterm-born offspring over time and provide more comprehensive heart phenotyping for preterm-born children. together, this information can be used to design future intervention strategies in preterm-born individuals to reduce cardiovascular risk in this growing subgroup of the population.

Eligibility criteria:
inclusion criteria: * participant's parent or legal guardian gives consent and the participant, where age-appropriate, gives assent for participation in the study. * participant is male or female, aged 3-9 years at enrolment. * participant previously took part in the epoch study, or the participant's friend or sibling took part. exclusion criteria: * evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status for exclusion of mri component only: * contraindication to mri * unsuitable for mri based on the responses to the mri screening form

Keywords: cardiac function preterm children
artificial intelligence to assess the association between facial characteristics and coronary artery diseases

Conditions: Coronary Artery Disease

Summary: the purposes of this study are 1) to explore the association between facial characteristics and the increased risk of coronary artery diseases; 2) to evaluate the diagnostic efficacy of appearance factors for coronary artery diseases.

several age-related appearance factors were described associated with increased risk of coronary artery diseases (cad). however, several limitations made these facial risk factors hard to be utilized in clinical practice, including 1) low prevalence in cad patients, 2) lack of specific definition, 3) poor reproducibility in artificial recognition. thus, the investigators designed a multi-center, cross-sectional study to explore the association between facial characteristics and cad and evaluate the diagnostic efficacy of appearance factors for cad. the investigators will recruit patients undergoing coronary angiography or coronary computer tomography angiography. patients' baseline information and facial images will be collected. first, the investigators will explore the facial factors associated with cad by using artificial intelligence technology to compare facial photographs between patients with cad and without cad. secondary, the investigators will evaluate the dose-response relationship between facial characteristics and cad. third, the investigators will establish a cad risk model based on facial factors, and evaluate the diagnostic effect of the model.

Eligibility criteria:
inclusion criteria: * undergoing coronary angiography or coronary computer tomography angiography * written informed consent exclusion criteria: * prior percutaneous coronary intervention (pci) * prior coronary artery bypass graft (cabg) * screening coronary artery disease before treating other heart diseases * without blood biochemistry outcome * with artificially facial alteration (i.e. cosmetic surgery, facial trauma or make-up) * other situations which make patients fail to be photographed

Keywords: artificial intelligence facial characteristics
biomechanical determinants of different rehabilitation protocols for acl reconstruction

Conditions: Knee Injuries; Rehabilitation

Summary: purpose of the study is to investigate the effects of the criterion rehabilitation protocol versus accelerated rehabilitation protocol on the biomechanical determinants of the quality of performance and risk of reinjury.


Eligibility criteria:
inclusion criteria: * amateur male athletes who underwent aclr surgery with an autologous hamstring (hs) graft. * ranging in age from 18 to 35 years. * underwent a pre-operative rehabilitation program with minimal knee effusion, full extension, good patellofemoral mobility * ability to actively control the quadriceps. exclusion criteria: * aclr with any graft other than a hamstring graft * acl revision surgery * associated medial or lateral ligamentous injuries * previous meniscectomy or meniscal repair * simultaneous meniscectomy or meniscus repair with the aclr * cartilage damage.
long term study of vah631 in patients with essential hypertension (extension from b1303 study)

Conditions: Hypertension

Summary: this study is designed to provide long-term safety and efficacy data for the combination doses of vah (val/ hctz) 40/6.25mg and 80/12.5mg in essential hypertensive patients. the 350 patients (approximately) who have successfully finished the core trial cvah631b1303 and signed consent for the extension will be enrolled into this study.


Eligibility criteria:
inclusion criteria: * patients who successfully complete the core study (protocol 1303) * outpatients exclusion criteria: * presence of crucial protocol violation in protocol 1303 * patients who experienced any adverse events considered serious and drug related in protocol 1303.

Keywords: hypertension valsartan hydrochlorothiazide
a study of investigational sar245409 in patients with certain lymphoma or leukemia

Conditions: Lymphoma

Summary: primary objective: - to evaluate the efficacy of sar245409 as determined by the objective response rate (orr) in patients with 1 of following relapsed or refractory lymphoma or leukemia subtypes: mantle cell lymphoma (mcl), follicular lymphoma (fl), chronic lymphocytic leukemia (cll)/small lymphocytic lymphoma (sll), or diffuse large b cell lymphoma (dlbcl) secondary objectives: * to assess duration of response, progression free survival (pfs), and proportion of patients with pfs at 6 months (24 weeks) in patients with either mcl, fl, cll/sll or dlbcl treated with sar245409 * to evaluate the safety and tolerability of sar245409 in patients with mcl, fl, cll/sll or dlbcl * to further characterize the plasma pharmacokinetics (pk) of sar245409 in patients with mcl, fl, cll/sll or dlbcl

there is a 21 day screening period followed by 28 day cycles. patients will continue to receive sar245409 as long as there is clinical benefit or until a study withdrawal criterion is met. the last posttreatment visit will be 30 days after the last dose or until imp-related toxicities have resolved or are deemed irreversible, whichever is later.

Eligibility criteria:
inclusion criteria: * tissue from an archived or fresh tumor sample * a peripheral blood buffy coat sample is required for cll/sll. * patient has mantle cell lymphoma (mcl), follicular lymphoma (fl), or chronic lymphocytic leukemia (cll)/sll or diffuse large b cell lymphoma * patient \> or = 18 years old * eastern cooperative oncology group (ecog) performance status \< or = 2. patients with dlbcl will have ecog \< or = 1 * adequate white blood cells and hemoglobin * good kidney and liver function * fasting glucose \< 160 mg/dl * no other malignancy * use of adequate birth control exclusion criteria: * treatment with cytotoxic chemotherapy, biologic agents, investigational therapies within 4 weeks, or nitrosoureas or mitomycin c within 6 weeks of study enrollment * treatment with a small-molecule kinase inhibitor within 2 weeks, or 5 half lives of the drug or its active metabolites (whichever is longer) of study enrollment * prior treatment with a pi3k, mtor, or akt inhibitor. prior treatment of mcl with temsirolimus is permitted in patients enrolled from countries where it is licensed for this indication. * radiation therapy within 2 weeks of enrollment * autologous stem cell transplantation within 16 weeks of enrollment * prior allogeneic transplantation except for patients with r/r dlbcl who meet inclusion criteria * central nervous system (cns) or leptomeningeal involvement. patients with dlbcl may have active cns or leptomeningeal involvement. * positive hepatitis b surface antigen (hbsag) or hepatitis c antibody (anti-hcv) serology * primary cns lymphoma * primary mediastinal b-lymphoma the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
gain of keratinized mucosa around teeth and dental implants using a combination of strip gingival graft and acellular dermal matrix

Conditions: Gingival Recession; Lack of Keratinized Attached Peri-implant Mucosa; Thin Gingiva

Summary: this study is to compare the two techniques to achieve change in the tissue quality at areas of lack of keratinized tissue (kt) using soft tissue grafting with autogenous graft material (free gingival graft)(fgg) vs strip gingival graft with acellular dermal matrix (adm) (sgg+adm).

this investigation is a randomized controlled trial of two techniques to achieve change in the tissue quality at areas of lack of keratinized tissue (kt) using soft tissue grafting with autogenous graft material (free gingival graft)(fgg) vs strip gingival graft with acellular dermal matrix (adm) (sgg+adm). to evaluate to determine if either grafting technique (fgg vs sgg+adm) demonstrates superiority in clinical (amount of kt increase, tissue thickness increase, and practitioner-assessed esthetics) and patient-centered outcomes (pain, swelling, change in daily activities, and patient-assessed esthetics) in a controlled study.

Eligibility criteria:
inclusion criteria: * english speaking * at least 18 years old * able to read and understand informed consent document * patients with teeth/implants lacking keratinized tissue. * must be a patient of the uab dental school * presence of periodontally healthy, non-carious neighboring teeth, healthy implants or edentulous ridges on either side of the involved site(s) exclusion criteria: * non-english speaking * less than 18 years old * smokers/tobacco users (\>10 cigarettes/day) * patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing * presence of active periodontal disease * previous soft tissue grafting at the site(s) to be treated

Keywords: attached mucosa keratinized tissue dental implants connective tissue