Kornimate/medical-research-clean huggingface dataset:
iron supplementation in schistosomiasis and soil transmitted helminths control programmes in zambia

Conditions: Schistosomiasis; Helminthiases; Anaemia

Summary: the objectives of this study is: * to establish the coverage rate of weekly iron supplementation in children in intervention schools over a period of nine months * document any side effects of weeekly iron supplementation among children in intervention schools over a period of nine months asses the feasibility of incorporating the weekly iron supplementation programme into the normal school activity in intervention schools determine the extent of acceptability and support for the iron supplementation programme by staff at the health centre nearest to the intervention schools * compare the praziquantel efficacy and schistosomiasis reinfection in children in intervention schools with that of children in control schools following the introduction of weekely iron supplementation over a period of nine months * determine the impact of weekly iron supplementation on haemoglobin levels of children in intervention schools and compare with children in control schools over a period of nine months

iron deficiency anaemia is a common denominator for both schistosomiasis and soil transmitted helminths. iron deficiency appears to affect the immune response against schistosomes and intestinal helminths. it therefore follows that correcting the iron deficiency anaemia will improve the efficacy of anthelminthics such as praziquantel (against schistosomiasis) and albendazol (against soil transmitted helminths) and ability of the host immune system to resist reinfection with schistosomes and soil transmitted helminths. the aim of this study is to identify factors necessary for a successful weekly iron supplementation programme in schistosomiasis and soil transmitted helminths control programmes. in addition impact of weekly iron supplementation programme n haemoglobin levels, efficacy of praziquantel, and schistosomiasis re-infection will be studied.

Eligibility criteria:
inclusion criteria:all schoolchildren, in grade 2 and 3, at four selected schools - exclusion criteria: -

Keywords: iron deficiency schistosomiasis soil transmitted helminths
interest of an adapted physical activity (apa) program among patients with juvenile idiopathic arthritis: a feasibility and efficacy preliminary study

Conditions: Juvenile Idiopathic Arthritis

Summary: the juvenile idiopathic arthritis (jia) affects joints mobility and leads pain, impacting the practice of physical activities. adapted physical activities are rehabilitation methods increasingly used, but additional studies are needed to define the nature of the physical activity for patients with jia. the athletique project aims to evaluate the impact of a program integrating apa sessions together with the wearing of a pedometer watch on disease activity of patients with jia.


Eligibility criteria:
inclusion criteria: * children (boys and girls) aged 6 to 17 years * children with juvenile idiopathic arthritis (jia) : oligoarticular, polyarticular, psoriatic or enthesitis-related arthritis, with more than one year of disease progression * children on stable conventional or biotherapy 3 months prior to inclusion * children with a computer/tablet/connected phone that allows them to follow adapted physical activities sessions online * if sexually active adolescents, use an effective method of contraception (oral contraceptives, contraceptive injections, intrauterine devices, double barrier method, contraceptive patches) * signed informed consent to participate indicating that the parent(s) understand the purpose and procedures required for the study and agree(s) that their child(ren) will participate in the study and abide by the requirements and restrictions of the study * affiliation with a french social security system or beneficiary of such a system. non-inclusion criteria: * treatment by intra-articular infiltration less than 1 month old (immobilization required after the procedure and temporary cessation of physical activity unavoidable) * contraindications to physical activity * subject unlikely to cooperate with the study and/or poor cooperation anticipated by the investigator * subject without health insurance * pregnant adolescent * subject in the exclusion period of another study or is the "national volunteer register" exclusion criteria : * intra-articular infiltration treatment during the 3 months of the adapted physical activity (apa) program (except for the temporomandibular joint) * change of biotherapy during the 3 months of the apa program if the treatment is ineffective * physical inability to engage in physical activity, unrelated to jia, during the 3-month of the apa program
efficacy of handheld acne heat device

Conditions: Acne Vulgaris

Summary: the aim of our study is to determine the time to resolution of individual acne lesions using a popular handheld heat based device in comparison to no treatment and to standard topical therapy with benzoyl peroxide in order to determine its effectiveness in the spot treatment of acne vulgaris. patient satisfaction and potential side effects will be examined as well.


Eligibility criteria:
inclusion criteria: * are 12- 64 years old * have an investigator's global assessment of greater than or equal to 2 * have 8-16 inflammatory acne facial lesions (papules and pustules) exclusion criteria: * have any severe facial acne at baseline, including large acne lesions and cysts (nodulocystic acne) * have used any topical anti-acne medications, systemic antibiotics, and/or systemic corticosteroids 4 weeks before the study start * have used oral acne medications, such as accutane (systemic retinoid), 6 months before the study start * have had a facial procedure 2 weeks before the study start * are nursing or pregnant * are using any oral contraceptives that have a specific anti-androgenic action or if you have started using a new oral contraceptive 12 weeks before the study start * are using any medications known to exacerbate acne * have a known hypersensitivity or allergy to benzoyl peroxide or any of the vehicle constituents * have a beard or facial hair that could interfere with study evaluations
effects of different designs of orthokeratology lens on myopia control and visual quality

Conditions: Myopic Progression

Summary: this study was aimed to evaluate the effects of different orthokeratology，including the size of central optical zone and the height of peripheral reverse curve, on myopia control and visual quality.

this study was aimed to evaluate the effects of different orthokeratology on myopia control and visual quality. the different optical zone of orthokeratology lens was divided into 4 groups, ranged from 5.5 mm to 6 mm. and the control group subjects with the single glasses was included. the effectiveness of orthokeratology was measured by axial length progression. the visual quality of subjects was evaluated by a questionnaire, contrast sensitivity and wavefront aberration.

Eligibility criteria:
inclusion criteria: * myopia: between -1.00d and 4.00d in both eyes * astigmatism: \<1.5d for with-the-rule astigmatism, \<1.00d for the against-the-rule astigmatism * visual acuity: the best corrected vision acuity(bcva)≥20/20 in both eyes * subjects that volunteer to participate in the clinical trial and sign informed consent exclusion criteria: * contraindications of wearing ortho-k. * diagnosis of strabismus, amblyopia and other refractive development of the eye or systemic diseases. * any type of strabismus or amblyopia * systemic condition which might affect refractive development (for example, down syndrome, marfan's syndrome) * ocular conditions which might affect the refractive error (for example, cataract, ptosis)
telerehabilitation program and detraining in patients with post-covid-19 sequelae

Conditions: COVID-19 Acute Respiratory Distress Syndrome

Summary: the primary objective of this study is to evaluate the effects of a 15-week home telerehabilitation program and a detraining period on cardiorespiratory fitness and muscular efficiency in patients with post-covid-19 sequelae compared to a control group of covid-19 patients. we hypothesize that cardiorespiratory fitness and muscular efficiency significantly improve in patients who carry out the home telerehabilitation program. however, the cardiorespiratory and muscular adaptations achieved and tolerance to exercise are lost over time as an effect of detraining.


Eligibility criteria:
inclusion criteria: * age \> 18 years * molecular diagnosis (reverse transcription polymerase chain reaction \[rt-pcr\]) of infection by sars-cov-2 * post-covid-19 symptomatology exclusion criteria: * severe neurological disease * active oncological disease * neuromuscular disease and/or orthopedic disorders impeding normal development of cardiopulmonary exercise test * the absence of signed informed consent
the effect of gut microbiota on the prognosis of sepsis

Conditions: Sepsis

Summary: sepsis is a life-threatening condition that arises when the body's response to infection injures its own tissues and organs. common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion. clinically, sepsis patients with diarrhea often result in a bad prognosis. gut microbiota consists of a complex community of microorganisms that live in the digestive tracts of animals. the gut microbiota comprises the largest and most diverse reservoir of mutualistic microorganisms associated with animals. the aims of this study is to determin the effect of gut microbiota on the prognosis of sepsis, by using 16s pyrosequencing, comparing the blood culture result.


Eligibility criteria:
inclusion criteria: * subjects diagnosed with sepsis * 18 years to 65 years of age exclusion criteria: * patients had complications such as acute cerebral infarction or acute myocardial infarction * the use of antibiotics, pro-prebiotics within 3 months * \ 65 years * history of intestinal surgery * patients withdraw from this study

Keywords: sepsis gastrointestinal microbiome gut microbiota gut flora intestinal flora
effect of anorectal biofeedback on encopresis in school aged girls after sexual assault

Conditions: Fecal Incontinence

Summary: females who have been sexually abused anally, have a disturbed anorectal motility. they have an increased resting pressure at the lower part of the anal canal. when their rectum is suddenly distended, they tend not to have an initially increased pressure in the anal canal, and the recto-anal inhibitory reflex is markedly decreased amplitude which is caused by reflex contraction of the pelvic floor during the relaxation of the internal anal sphincter.

the cause of fecal incontinence after sexual abuse is the improper functioning of anal sphincter muscles, as a result of their damage and/or neurological changes including the disturbance perception of sensory stimuli from the anal canal. biofeedback therapy using visual and verbal feedback techniques has emerged as an useful option in managing fecal incontinence and levator ani syndrome. the goal of biofeedback training is to improve bowel function by restoring a normal pattern of defecation.

Eligibility criteria:
inclusion criteria: * absent anal reflex, * skin trifles around the anus, * funnel shaped anus * medically stable and able to follow instructions exclusion criteria: * sexual transmitted disease * any medical condition that affect the anus potentially such as crohn's disease, * severe chronic constipation, * myotonic dystrophy
vestibular socket therapy (vst) in infected and non infected sockets

Conditions: Implant Site Infection

Summary: vestibular socket therapy with immediate implant placement is compared in infected and non-infected sockets regarding implant survival, bone thickness and soft tissue height .

for non infected sockets, a 15c blade (stoma, storz am mark gmbh, emmingen-liptingen germany) was used to cut a 1-cm long vestibular access incision , 3-4 mm apical to the mucogingival junction of the involved tooth. the socket orifice and the vestibular access incision were connected by a subperiosteal tunnel that was created using a periotome and a micro-periosteal elevator (stoma, storz am mark gmbh, emmingen-liptingen germany). implants, (biohorizons, birmingham, al, usa) , were installed using a 3d printed surgical guide (surgical guide resin, form 2, formlabs). a flexible cortical membrane shield (osteobiol® lamina, tecnoss®, torino, italy) of heterologous origin, 0.6 mm in thickness was prepared by hydrating and trimming it. it was then tucked through the vestibular access incision, till it extended 1 mm below the socket orifice, and stabilized using a membrane tack (autotac system kit, biohorizons implant systems, birmingham, alabama inc, usa) to the apical bone. the gap between the implant and the shield/the labial plate was then filled with particulate bone graft \[75% autogenous bone chips harvested form local surgical sites and 25% inorganic bovine bone mineral matrix (mineross x , biohorizons, birmingham, al, usa)\]. for the infected sockets, the 6-day protocol was implemented. atraumatic extraction of the infected tooth by the periotome was followed by curettage, mechanical debridement and chemical irrigation using metronidazole irrigation solution (500mg/100ml, amrizole, amria pharma, alexandria, egypt). the root of the involved tooth was cleaned with an ultrasonic cleaner, cut to its apical third, reimplanted into the socket and maintained there for 6 days by bonding its crown to the adjacent teeth using composite resin. implant and crown placement were done as described above for the non-infected socket group.

Eligibility criteria:
inclusion criteria: * all patients were adults ≥ 18 years, * 1-5 non-adjacent hopeless maxillary teeth in the esthetic zone. * the involved teeth had type ii sockets. * to achieve optimum primary stability for the implants (30ncm insertion torque), adequate palatal and at least 3 mm apical bone should be available to engage the immediately placed implants. exclusion criteria: * smoking and/or pregnant patients * systemic diseases * a history of chemo- or radiotherapy within the past 2 years were excluded.
phase 2a, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacodynamics of ep262 in subjects with atopic dermatitis

Conditions: Atopic Dermatitis

Summary: this phase 2a trial will evaluate the effects of ep262 in subjects with atopic dermatitis


Eligibility criteria:
inclusion criteria: * clinically confirmed diagnosis of active atopic dermatitis for at least 1 year * bsa of 3% to 20% and a viga-ad score of ≥3 exclusion criteria: * other active skin diseases associated with chronic pruritus * clinically infected atopic dermatitis that requires antibiotic therapy * use of specific treatments for atopic dermatitis
behavioural activation for bipolar depression: a case series

Conditions: Bipolar Depression

Summary: bipolar disorders affect around 2% of the population. most people with bipolar experience depression; these periods can cause difficulties with relationships, work and daily life. psychological therapies for "unipolar" depression (for people who experience depression but never mania or hypomania) are widely available, but there is little research in to how effective these therapies are for people with bipolar. knowing this could give greater choice to people with bipolar in terms of the therapy they have, and how easy it is to get within the nhs. one such therapy is called behavioural activation (ba). ba is an established therapy for people with unipolar depression. it helps people to re-establish healthier patterns of activity, but so far there is very little research into offering ba to people with bd. the current research involves a small number of people with bipolar depression receiving ba to see if it seems sensible and worthwhile to them, and to help us to make any necessary improvements to the therapy. the study is taking place in devon and is sponsored by the university of exeter. 12 people that are currently experiencing bipolar depression who choose to take part will receive up to 20 individual therapy sessions of ba that has been adapted for bipolar depression (ba-bd), and will complete regular questionnaires and interviews. the results of this study will not give the final answer on how effective ba is for people with bipolar depression, but will help to plan for a larger study that can answer this question.


Eligibility criteria:
inclusion criteria: * scoring in the clinical range on a self-report measure of depression severity (the phq-9) * meeting diagnostic criteria for depression based on a structured clinical interview for diagnosis (scid-5) * meeting diagnostic criteria for bipolar i or ii disorder (scid-5) * participants will require working knowledge of written and spoken english, sufficient to be able to make use of therapy and to be able complete research assessments without the need of a translator. exclusion criteria: * current/past learning disability, organic brain change, substance dependence (drugs and alcohol) that would compromise ability to use therapy * current marked risk to self (i.e. self-harm or suicide) that we deem could not be appropriately managed in the accept clinic at the mood disorders centre * currently lacking capacity to give informed consent * currently receiving other psychosocial therapy for depression or bipolar disorder * presence of another area of difficulty that the therapist and client believe should be the primary focus of intervention (for example, post-traumatic stress disorder, psychosis).

Keywords: behavioural activation bipolar disorder bipolar depression multiple baseline case series
geography of ed use and population health

Conditions: Emergencies; Diabetes Mellitus

Summary: the goal of this study is to create predictive models of emergency care and metrics for population health that can be used to analyze how events like hospital closures or disasters like hurricane sandy affect health care utilization by patients in specific populations or geographic regions. additionally, it will allow the development of metrics for population health that can act as surveillance mechanisms to measure disease prevalence and identify patterns in emergency department use that can be used to identify specific geographic regions where health care is either optimized to promote health or needs to be improve so that population health can be improved.

the purpose of this study is to analyze the geographic patterns of emergency department utilization. this study will look at the relationship that geographic proximity and local population factors have on patient use of emergency departments. geographic proximity of alternative hospitals and elicit other patient and hospital specific factors, such as demographic, insurance type, diagnosis, and socioeconomic factors that lead patients to choose specific hospitals for emergency care or generally lead to patients accessing emergency care will be compared. patterns of emergency department utilization by patients will be identified in specific geographies such as census tracts to determine clusters of high and low emergency department use. we also analyze the patterns of emergency care use based on specific disease conditions.investigators will analyze the rate of emergency department use for patients with diabetes to determine population prevalence of diseases using emergency department data. studying the pattern of use by specific geographies or disease conditions will also allow us to understand how emergency department use varies among populations by geographies and the socioeconomic and health care factors local to those regions.

Eligibility criteria:
inclusion criteria: * patients visiting an emergency department in new york state exclusion criteria: * depending on the population analyzed, may exclude some subpopulations such as children (in order study adults), prisoners or patients transferred from other healthcare facilities (in order to study non-institutionalized individuals).

Keywords: epidemiology research
fame - fampyra outcome measures study: a study of different outcome measures on the effect of fampyra

Conditions: Multiple Sclerosis

Summary: fampridine-sr is registered for the treatment of walking incapacity in ms patients. two pivotal trials show that app. 40% of ms patients with walking incapacity can improve walking speed averagely 25% when recieving the drug. this has been shown using the timed 25 foot walk test (t25fw). no effect on cognition and upper limb function has been shown, but this has not been investigated in patients responding to the drug measured by the abovementioned test. the question is if this will be the case and also if another walking test, termed the six spot step test (ssst), will be more sensitive to the effect of fampridine-sr. primary outcome measure is the effect measured by ssst. the hypothesis is that ssst is not less sensitive to the effect of fampridine-sr than t25fw.


Eligibility criteria:
inclusion criteria: * patients with clinically definite multiple sclerosis diagnosed according to the mcdonald criteria * edss 4-7 * pyramidal fs \>= 2 exclusion criteria: * history of epileptic seizures * ms relapse or change in disease modifying treatment (dmt) within 60 days * cancer within five years * uncontrolled hypertension * clinically important cardiac, hepatic, renal or pulmonary disease * pregnancy * breast feeding * concomitant treatment with cimetidine, carvedilol, propranolol and metformin

Keywords: multiple sclerosis walking disablility mobility six spot step test outcome measures fampridine-sr fampyra
research of factors determining the improvement of quality of life at one year of adult patients treated for spinal deformity (coftasd)

Conditions: Spinal Deformity

Summary: the objective of this study is to find the predictive factors of improvement of the quality of life of operated patients from spinal deformity.


Eligibility criteria:
inclusion criteria: * age over 18 years-old * diagnosis of adult spinal deformity with any of the deformity characteristics following: * scoliosis with a cobb angle ≥ 20 ° * vertical sagittal axis (sva) ≥ 5 cm * pelvic tilt ≥25 °, * thoracic kyphosis with a cobb angle ≥ 60 ° * eligible for surgery * having given their participation agreement * affiliate or beneficiary of a social security scheme exclusion criteria: * age under 18 years-old * patient unlikely to comply with follow-up * patient with long-term complete paraplegia * patient unable to understand and answer questionnaires in due to language difficulties or cognitive impairment * pregnant or breastfeeding woman * protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision