Kornimate/medical-research-clean huggingface dataset:
pilot of acupuncture to improve quality of life in veterans with tbi and ptsd

Conditions: Post-traumatic Stress Disorders

Summary: the purpose of this study is to examine if acupuncture improves post-traumatic stress disorder symptoms among veterans who participated in operations enduring freedom and iraqi freedom. this study will also examine the degree of veteran acceptance for acupuncture.

project background: acupuncture can be effective for many of the specific co-morbidities that make up war-related trauma spectrum disorder in both tbi and ptsd patients, including pain, stress and anxiety, insomnia, somatic and post-operative pain. recent studies find very large effect sizes (cohen's d .85 to 1.4). thus, there is good reason to believe that acupuncture will induce recovery across a number of trauma spectrum dysfunctions in patients with tbi and ptsd, at low cost and with little risk. project objectives: the overall objective of this application is to determine the efficacy of adjunctive acupuncture for improving quality of life and function and alleviating co-morbidities associated with tbi and ptsd in service members injured in the current wars. the primary hypothesis of this study is: oif/oef veterans who screen positive for tbi or ptsd and are treated with a 12 week standard individualized acupuncture method will experience improved hrql (as measured by the veteran's sf-36) at 6, 12 and 24 week follow-up, compared to veterans randomly assigned to standard care alone. project methods: this is a pilot study on veterans who screen positive for tbi or ptsd in the va healthcare record, which is being submitted to obtain additional pilot data, confirmation of recruitment strategies, and information on non-participants . frequency distribution and summary statistics for demographics and baseline variables will be presented by intervention group and for all subjects combined. key demographic variables to be summarized are: age, gender, time to deployment, number of deployments, and diagnosis. key baseline variables are: ptsd caps score, vsf-36, and anam score.

Eligibility criteria:
inclusion criteria: * diagnosis or positive screen test for ptsd. * combat veterans of operation iraqi freedom or operation enduring freedom conflicts. exclusion criteria: * unable to travel to east orange va for 12 consecutive weeks, biweekly for treatment. * does not speak english. * acupuncture or cbt treatment within the previous six months.

Keywords: post-traumatic stress disorders acupuncture quality of life sleep disorder
south asian yoga and exercise trial

Conditions: Obesity

Summary: south asians have one of the highest rates of heart disease of all populations and a unique and deleterious obesity phenotype of increased body fat and inner-abdominal compared to those of european background. we have subsequently identified that this unique phenotype accounts for much of the increased heart disease risk in south asians, with the greater amounts of inner abdominal fat being particularly implicated. in addition, south asians in canada have substantially lower levels of leisure-time physical activity. at present, we do not know the answers to the following questions: 1. is a conventional (standard) physical activity program that has proven effective at reducing inner abdominal fat and heart disease risk factors in populations of european background be effective in south asians? 2. is an alternative physical activity program commonly practiced by south asians (such as bhangra dance) be effective at reducing inner abdominal fat and heart disease risk factors in south asians? in this study, we will perform a randomized controlled trial of three conditions-gym-based standard exercise program (se),bhangra dance exercise program (be) and non-exercise control (ne).we will recruit 75 post-menopausal south asian women with abdominal obesity and assign them randomly to one of the three groups (25 per group). we anticipate that both the se and be programs will be superior to the ne group in terms of reducing vat and cvd risk factors. such findings will demonstrate that exercise is an effective method that favourably modifies the obesity phenotype of excess vat in south asians, and should be central to health promotion and disease prevention strategies.


Eligibility criteria:
inclusion criteria: * post-menopausal south asian women defined as not menstruating for the previous 12 consecutive months as assessed by self report * waist circumference \>80 cm (women), as identified as south asian cut offs by international diabetes federation109 * able to read and write and understand english * previously sedentary (\<150 minutes of physical activity per week as assessed by accelerometry) * weight stable (\<2kg of weight change over the past 6 weeks) exclusion criteria: * taking medication that may affect study outcomes (lipid-lowering, antihypertensive, or hypoglycemic medications) * unable to provide informed consent * individuals \> 136 kg (physical limitation of dxa scanner table) * smokers (given the confounding association between smoking and adiposity) * unable to participate in exercise sessions due to physical limitations or contra-indications to regular exercise as indicated on the baseline maximal exercise stress test * individuals with known cvd or other known comorbidities (hiv, immune compromised condition, type 1 or 2 diabetes mellitus) * another member of the household already participating in study

Keywords: south asian cardiovascular exercise obesity visceral adipose tissue
effect of clear aligner attachment design on extrusion of maxillary lateral incisors

Conditions: Maxillary Lateral Incisor Malocclusion

Summary: the purpose of this research is to test which of four clear aligner attachment types is more efficient in extruding (erupting) maxillary lateral incisors vertically into correct position during orthodontic treatment.

attachments are small tooth-colored shapes that are bonded (attached) to teeth before or during treatment with clear aligners. they are like handles, giving aligners something to gently push teeth into correct positions. there are 4 different shapes of attachments that are commonly used to extrude lateral incisors (incisally-beveled, gingivally-beveled, optimized and horizontal). all 4 of these attachments are successful in extruding lateral incisors but there is not enough research evidence to know for sure which attachment would be ideal for a specific circumstance.

Eligibility criteria:
inclusion criteria: 1. patients 16 years or older to be treated with either comprehensive invisalign or invisalign teen, 2. maxillary lateral incisor requiring 0.3 mm or more extrusion (as determined by clincheck), 3. maxillary arch with less than 6 mm of crowding or spacing, 4. all teeth present and fully erupted (excluding third molars). exclusion criteria: 1. presence of anterior crossbite 2. any missing teeth in the maxillary arch 3. treatment plan includes surgery or extraction of any maxillary teeth, 4. maxillary lateral incisors with pathology or large restorations (crowns) 5. maxillary lateral incisors have a less than 0.3 mm of extrusion prescribed in the tooth movement table on the invisalign clincheck
long-term study of hospitalized dengue & safety in thai children included in a tetravalent dengue vaccine efficacy study

Conditions: Dengue; Dengue Fever; Dengue Hemorrhagic Fever

Summary: the purpose of this study was to conduct a passive surveillance of hospitalized dengue cases in participants who participated in study cyd23 (nct00842530). the objectives: * to describe the incidence of virologically-confirmed hospitalized dengue cases. * to characterize hospitalized dengue cases. * to evaluate the occurrence of related and fatal serious adverse events (saes).

this study was a passive surveillance of hospitalized dengue cases in participants who participated in study cyd23 (nct00842530) where participants were initially randomized to receive 3 injections of either cyd dengue vaccine or control at 6 month intervals. any sae related to a study procedure or related to a previous injection from study cyd23, or any fatal saes (even if unrelated) were reported to the sponsor. an independent data monitoring committee (idmc) was also involved in the regular review of virologically-confirmed hospitalized dengue cases. any fatal outcome or related sae were be promptly reviewed by the idmc. no study vaccinations were administered.

Eligibility criteria:
inclusion criteria: * ongoing participation in study cyd23 at the time of enrolment. * assent form was signed and dated by the participant (for participants \>= 7 years old), and informed consent form was signed and dated by the parent(s) or another legally accepted representative and by 2 independent witnesses. * participant and parent/legally accepted representative were able to attend all scheduled visits to comply with all study procedures. exclusion criteria: * planned participation in another dengue clinical trial during the present study * deprived of freedom by an administrative or court order, or in an emergency setting, or hospitalized involuntarily.

Keywords: dengue virus dengue fever dengue hemorrhagic fever cyd dengue vaccine
post-operative anemia in lateral fractures of the femur.

Conditions: Femur Fracture

Summary: it was conducted a prospective study with a series of 45 patients with lateral fragility fractures of the femur treated by three different intramedullary nails. patients were randomized in group a (15 patients treated by affixus zimmer-biomet), group b (15 patients treated by eba2 - citieffe) and group c (15 patients treated by proximal femoral nail antirotation synthes). one independent observer performed seven biochemical evaluations (hemoglobin serum value) from admission to patient discharge. surgical time and blood transfusions number were reported for each partecipant.


Eligibility criteria:
inclusion criteria: * femur fractures type 31-a1, a2, a3 (muller me, nazarian s, kock p et al.); * age more than 65 years; exclusion criteria: * patients with neurological diseases; * finding of anemia before surgery;

Keywords: fragility lateral femoral fractures intramedullary nail post-operative anemia surgical time blood transfusions number
comprehensive assessment of atherosclerotic ischemic stroke risk and development of a prediction model

Conditions: Carotid Stenosis; Ischemic Stroke

Summary: this observational study was designed for the assessment of plaque vulnerability in patients with carotid atherosclerotic stenosis and the development of predictive models for the occurrence and recurrence of atherosclerotic ischemic stroke. the objectives of the study were as follows: first, to integrate the degree of carotid stenosis and plaque characteristics assessed by vascular ultrasound for a comprehensive assessment of plaque vulnerability; second, to develop an assessment tool for the risk of future ischemic stroke in patients with asymptomatic carotid stenosis by combining vascular risk factors, serologic markers, carotid ultrasound characteristics, and contrast-enhanced ultrasonographic parameters; and third, to incorporate vascular ultrasound parameters into existing predictive models of ischemic stroke recurrence risk to develop a risk assessment tool for atherosclerotic ischemic stroke. the main questions it aims to answer are: * how to screen high-risk patients and those eligible for revascularization from asymptomatic carotid stenosis patients for primary prevention of stroke. * how to improve the prediction accuracy of atherosclerotic ischemic stroke based on existing prediction models for secondary prevention of stroke.

the data from january 2022 to december 2022 was obtained from the electronic medical record system, but there will be a two-year follow-up of the data. therefore, this is a two-way cohort study, containing both a retrospective and prospective cohort.

Eligibility criteria:
inclusion criteria: * ① patients aged ≥ 40 years old; ② complete clinical data and serological indicators; ③ carotid artery ultrasound examination was performed after admission. exclusion criteria: * ① unilateral or bilateral carotid artery occlusion; ②carotid stenosis caused by other reasons, such as entrapment, aortitis, radiculopathy and muscle fiber dysplasia; ③previous carotid stenting or carotid endarterectomy; ④carotid artery plaques are strongly echogenic with acoustic shadowing, resulting in unclear detection of the lumen.

Keywords: plaque vulnerability vascular ultrasound atherosclerosis ischemic stroke contrast-enhanced ultrasound
gem: impact of a video education tool on decisional conflict among prenatal patients

Conditions: Aneuploidy; Genetic Counseling; Informed Consent; Decisional Conflict

Summary: the goal of this randomized clinical trial is to assess the impact of a video educational tool on patient decisional conflict at the time when making a decision about prenatal genetic testing. the control group will receive standard prenatal care. the secondary aims include assessing the impact of the video educational tool versus standard care on pregnant participants': perception of likelihood of having a baby affected by a genetic problem, intended plan for genetic testing, patient-provider communication, retention of prenatal genetics knowledge, and perception of genetic data privacy. participants will be asked to: 1. watch video education (if randomized to this group) and complete a baseline survey at their dating ultrasound regarding knowledge of prenatal genetics, prior experiences, and demographics 2. complete a follow up survey after seeing their prenatal care provider regarding: decisional conflict scale with respect to prenatal genetic testing decision (primary outcome), perception of likelihood of having a baby affected by a genetic problem (secondary outcome) and the type of genetic testing chosen (secondary outcome). 3. complete a second follow up survey six to ten weeks from the second survey to assess: provider patient communication, retention of genetics knowledge, patient recollection of testing performed, and self-reported out of pocket cost related to genetic testing.


Eligibility criteria:
inclusion criteria: * patient ≥ 18 years of age * preferred language english or spanish * singleton pregnancy * no documentation of genetic screening results or counseling during this pregnancy * gestational age \<24 weeks exclusion criteria: * diagnosed with a fetal anomaly * diagnosed with known abnormal nuchal translucency test * diagnosed with fetal loss * use of a donor oocyte (egg) this pregnancy * prior involvement in other research study regarding prenatal genetic testing in the past two years
effectiveness trial of the french blues indicated depression prevention program

Conditions: Depression

Summary: the purpose of this pilot study is to test the effectiveness of french adaptation of the blues program, a school-based indicated depression prevention intervention. the program will be delivered by the endogenous psycho-social staff of 3 montreal secondary schools to adolescents with sub-clinical depressive symptoms and compared to a no-intervention (informational brochure only) control condition, designed to represent the "usual intervention" in these schools.


Eligibility criteria:
inclusion criteria: * elevated depressive symptoms (score of 20 or above on the center for epidemiological studies - depression screening questionnaire) exclusion criteria: * current major depression diagnosis * current active suicidal behaviors * being in a special school curriculum for academic or behavioral problems

Keywords: depression prevention adolescents school effectiveness
tailored internet information supply for patients - part 2

Conditions: Headaches

Summary: medical expert systems in combination with portal searching meta-search engines are exploited to provide reliable patient-tailored information. a prototype of a web-based information system has been developed and is to be evaluated. its aim is to answer the decisive question whether expert system guided internet meta-search provides a better information supply for patients seeking health information online then this is possible by using ordinary search engines or health portals. the research does neither investigate the influence of ethical nor legal aspects of internet health information supply.

the study is a follow-up of nct00746408. it has been conducted because for the first study still not enough participants have been recruited. the study took part at bamberg university in germany with 140 participants.

Eligibility criteria:
inclusion criteria: * can use a computer * can surf the internet exclusion criteria: * is a medical expert

Keywords: internet information supply tailoring patient empowerment headaches meta-search consumer health information information services information storage and retrieval information systems
feasability of collaborative care in the secondary prevention of coronary heart disease

Conditions: Coronary Heart Disease

Summary: the main focus of the pilot study is to evaluate the feasability and effectiveness of a collaborative care intervention for patients suffering from a coronary heart disease (chd) with insufficient controlled health related risk factors in their lifestyle. the design of the study is a wait list control design. 30 patients will receive treatment immediately after submission, the other 30 after 6 months. an interdisciplinary team, including a care manager for each patient, will offer an individualized treatment plan, based on shared decision making for each patient to reduce risk factors and improve quality of life.

the following assumptions will be evaluated: 1. the collaborative care concept is feasable in the context of the german health care system and leads to greater patient satisfaction 2. the team-based intervention leads to a decrease of cardiovascular risk factors of patients in the intervention group compared to participants in the waitlist condition 3. the collaborative care intervention leads to an improvement of quality of life as well as mental well being of participants in the intervention group compared to participants of the waitlist condition

Eligibility criteria:
inclusion criteria: * both sexes * coronary heart disease (angiographically oder clinically approved) * sufficient knowledge of the german language * at least one not sufficient controlled risk factor : diabetes mellitus (hba1c\>7,5%), smoking, lack of physical activity (less than 60 minutes of light physical exercise per week), heightened stress level (pss-4 \>5), arterial hypertension (blood pressure despite medication repeatedly heightened \>140/90 or in a 24-hour measurement \>135/85 mmhg), hypercholesteremia (ldl \>130 mg/dl) * written informed consent to participate exclusion criteria: * no existence of an medically approved coronary heart disease * insufficient knowledge of the german language and ulterior disabilities to complete the questionnaires or to understand the education about the intervention * existence of a psychosis * drug dependency (except tobacco) * dementia * severe episode of depression * current suicidal tendency * cardiac insufficiency nyha 4 * missing informed consent * malign tumor (unless curative treated and without relapse) * acute coronary syndrome or cardiosurgery within the last 3 months

Keywords: secondary prevention coronary heart disease myocardial infarction cardiovascular risk factors collaborative care quality of life patients´ satisfaction with treatment
seroprevalence of pertussis among healthy children and adolescents in kazakhstan

Conditions: Pertussis

Summary: seroprevalence of pertussis among older children and adolescents in kazakhstan: a cross sectional study. justification: to describe the distribution of anti-pertussis toxin (pt) antibodies (iga and igg) in a population aged 10-18 years old according to sociodemographic characteristics, vaccination history, and risk factors of pertussis infection.

pertussis due to infection with bordetella pertussis (b pertussis) is a well-known cause of persistent cough primarily affecting infants and young children. repeated administration of the vaccine is often needed to reduce the disease burden and control its transmission. at this time, no data are available on the epidemiology of pertussis in adolescents and adults in kazakhstan. the aim of the present study is to estimate the prevalence of pertussis infection in different age groups in kazakh children and adolescents using the anti-pertussis toxin (pt) antibodies (iga and igg) as specific marker of pertussis infection or vaccination. the serosurvey will be conducted in 4 different regions: aktobe, karaganda, taldykorgan, and shymkent. participants (≥ 10 years \& \< 19 years) attending the study centers will be asked to participate in the study. the adolescent participants and the parents/guardian(s) of all participants will be informed about the procedures and data handling. written informed consent from one parent/guardian needs to be obtained by the physician before any blood samples can be taken. upon obtaining informed consent for participant parent/guardian, the study coordinator will complete an investigation form (if) for each participant and collect serum samples. the specimens will be coded by a unique participant number and delivered to the laboratory in charge of the assay. the specimens will be used for serological analyses.

Eligibility criteria:
inclusion criteria: 10-18 years old * informed consent obtained from parents or guardian(s) and assent from patient. * enrollment following a visit at the study center. * documented vaccination history exclusion criteria: inclusion criteria: * 10-18 years old * informed consent obtained from parents or guardian(s) and assent from patient. * enrollment following a visit at the study center. * documented vaccination history exclusion criteria: * ≤10 years and ≥ 19 years * pertussis immunization during the last 12 months * no informed consent obtained from one parent or guardian. * immunocompromised patients * patients with acute infectious diseases

Keywords: pertussis seroprevalence immunity antibodies kazakhstan vaccination