Kornimate/medical-research-clean huggingface dataset:
detecting activity to support healing

Conditions: Colorectal Cancer; Peritoneal Cancer; Sedentary Lifestyle

Summary: the goal of this research is to develop and test a technology-supported intervention to reduce sedentary behavior before and after cancer surgery. surgical oncology patients are at elevated risk for postoperative complications and readmissions. sedentary behavior increases markedly after surgery and hospitalization, and reducing sedentary behavior around the time of cancer surgery could reduce risk while also empowering cancer patients to take a more active role in their recovery.

colorectal or peritoneal cancer patients scheduled for surgical resection (n=60) will be randomized to either the sedentary behavior intervention or monitoring only. the intervention will use a bluetooth-enabled activity monitor to detect prolonged sedentary bouts, which will prompt a message delivered via smartphone suggesting that patients walk. the intervention will begin at least two weeks prior to scheduled surgery and will continue through the first 30 days at home following hospital discharge. outcomes will include objective activity and sedentary behavior, patient-reported symptoms and quality of life using standardized instruments, inflammatory biomarkers, and morbidity and hospital readmission 30-days after index discharge.

Eligibility criteria:
inclusion criteria: * scheduled for curative surgical treatment of metastatic colorectal or peritoneal cancer at upmc shadyside * ability to stand and walk unassisted prior to surgery * identified at least two weeks prior to their scheduled surgery date exclusion criteria: * unable to read and write in english
decreases in diffusing lung capacity for carbon monoxide (dlco) in occupational divers and their impact on decompression sickness risks

Conditions: Decompression Sickness

Summary: diving disorders and particularly decompression sickness (dcs) represent a major concern in recreational and occupational pressure-related activities. as a result of decompression from higher to lower ambient pressure bubbles which are formed in vascular flow and in tissues take part in embolism then resulting in dcs. individual factors such as vascular or respiratory defects are now considered to increase the risk of this dysbarism disease.

2 groups of occupational divers will be separated after a fitness medical examination by regarding dlco decrease or not. the divers will be evaluated before and 30, 60, 180 minutes after a 20 meters air dive. venous bubbles will be detected by precordial doppler 30 minutes after the dive. in association with this doppler, flow mediated dilation, blood samples analysing inflammatory and thrombotic factors and other biomarkers will be explored before and after the dive in order to know how vascular and respiratory tracts in this environment react.

Eligibility criteria:
inclusion criteria: * be professional and voluntary diver * man or woman aged 18 years or older * diffusing lung capacity for carbon monoxide measured beforehand in the study * no medical contraindication for hyperbaric * no hyperbaric constraint in 3 days before the dive * no prior decompression sickness * not to follow medicinal treatment modifying the vascular endothelial and/or the coagulation and/or the respiratory function * patient affiliated to social security * informed and signed exclusion criteria: * concomitant pathology identified by the investigator, justifying a contraindication for hyperbaric * pregnant and nursing mothers * patient who refuse to sign consent form

Keywords: alveolo-capillar membrane decompression illness diving occupational
the effect of pressure ulcer care package on the risk of pressure ulcer development

Conditions: Pressure Ulcer

Summary: this study aimed to determine the effect of pressure ulcer care package use on the risk of pressure ulcer development due to surgery in patients undergoing orthopedic surgery. it was planned as a randomized controlled study. the population of the study will consist of patients who underwent surgery in the orthopaedics and traumatology clinic of doğubayazıt dr.yaşar eryılmaz state hospital hospital hospital of ağrı provincial health directorate. the sample of the study will consist of patients who volunteered to participate in the study that meets the inclusion criteria. to obtain research data, the personal information form developed by the researcher in line with the literature, 3s operating theatre pressure wound risk assessment scale, pressure wound regions and stages monitoring form prepared according to npuap (2016) pressure wound staging system form will be used. statistical analysis of the data obtained from the study will be performed using the spss 25 (statistical package of social science) package program.


Eligibility criteria:
inclusion criteria: * orthopaedics and traumatology department * those who have undergone general or spinal anesthesia * without any communication problems * patients who volunteered to participate in the study exclusion criteria: * patients with pre-operative pressure ulcer * those who are bedridden * patients referred to the intensive care unit after surgery * patients who wish to leave the study will be excluded from the study.
goodness of clinical history during stemi pci

Conditions: Myocardial Infarction

Summary: the purpose of this study is to confirm or confute the hypothesis that in patients treated with primary pci is not always possible to collect an adequate medical history, the investigators created a clinical registry in which the investigators collect current or previous medical history relevant to des utilization , in two distinct times.

ghost registry use of drug-eluting stent (des) in stemi is sometimes limited, by the concern that adequate information, relating to the current or previous medical history, can not be obtained due to the patient's critical condition. a less than adequate medical history would expose patients treated with des to a particular risk in case that an absolute or relative contraindication to the required long-term double antiplatelet therapy is not fully elucidated before des implantation. to confirm or confute the hypothesis that in patients treated with primary pci is not always possible to collect an adequate medical history, we created a clinical registry in which we collect current or previous medical history relevant to des utilization , in two distinct times: time zero in which the medical history collection is taken in the cath-lab during the primary pci time one in which the second medical history collection is taken 4 days after the index procedure when the patient clinical conditions no longer impede an adequate medical history collection.

Eligibility criteria:
inclusion criteria: * all consecutive patients presenting with stemi treated with primary or rescue pci exclusion criteria: * patient in cardiogenic shock and all those patients unable to communicate with the doctors at the moment of medical history taking

Keywords: primary pci stent medical hystory antiplatelet therapy compliance
phase 4 study comparing iop lowering in oag or oh in caucasian or japanese subjects c-02-32

Conditions: Open-angle Glaucoma; Ocular Hypertension

Summary: the purpose of this study is to evaluate safety and efficacy of two different iop lowering medications after six weeks of treatment in caucasian and japanese subjects.


Eligibility criteria:
adults of caucasian and japanese ethnicity

Keywords: open-angle glaucoma ocular hypertension poag iris pigmentation japanese
beta glucosylceramide for treatment of nash

Conditions: Compliance Behavior

Summary: oral administration of betaglucosylceramide was shown effective in reducing inflammation in animal models and was found safe in humans.

patients with nash to receive the treatment versus placebo for 40 weeks followed by a liver biopsy.

Eligibility criteria:
inclusion criteria: * biopsy proven nash exclusion criteria: * other therapies
non-contact ecg sensor system for covid19

Conditions: COVID-19

Summary: the purpose of this study is two-fold. first we would like to confirm that non-contact ecg provides equivalency to current contact methods of obtaining ecg data. second we would like to investigate whether non-contact ecg can detect ecg changes prior to the onset symptoms from covid19.


Eligibility criteria:
inclusion criteria: * any employee of lake forrest memorial hospital presenting to work * age greater than 18 years-old exclusion criteria: * age less than 18 years-old * non-employee

Keywords: covid-19 ecg arrhythmia
evaluation of the efficacy of 0.8% hyaluronic acid gel

Conditions: Periodontitis

Summary: assess the clinical and laboratory effects of the local and sub gingival application of a 0.8% hyaluronic acid gel (gengigel®) as an adjunct to scaling and root planning (srp) in chronic moderate to severe periodontitis patients as indicated by expression of human beta definsin-2 (hbd2) in gingival crevicular fluid (gcf).

patients who fulfilled the selection criteria will be included in the study. one quadrant will be treated with ha gel (test) and the other without to serve as control. clinical examination will be done in a dental chair under standard conditions of light, using mouth mirror and graduated williams periodontal probe. all patients will receive full mouth scaling and root planing with hand instruments and ultrasonic scalers at baseline. thereafter, in the test quadrant, 1 ml of 0.8% hyaluronic acid gel will be administered subgingivally in all selected test sites at baseline and 1 week later. the following clinical parameters will be recorded at baseline, after 6 weeks and 12 weeks post treatment. oral hygiene instructions will be given to all patients. the clinical measurements and treatment will be performed by a single examiner.for every patient and control subject, gcf samples will be collected at baseline, 6 weeks and 12 weeks post treatment. the samples will be pooled from two periodontal sites with clinical attachment level of 3 mm or more (in the two different quadrants). the sampling area will be isolated with cotton rolls and carefully will be cleaned supragingivally with sterile cotton pellets. a sterile absorbent paper point will be inserted into the gingival crevice or pocket until resistance will be felt. the paper point will be held in place for 30 s and then will be transferred to a vial containing 100 μl of distilled water and vigorously will be mixed. the paper points will be removed, and the samples will be centrifuged and will be washed twice with distilled water. the resultant pellets will be resuspended in 0.4 ml of distilled water. the samples will be coded and stored at -70 °c until use for elisa test for identification of human beta defensin-2.

Eligibility criteria:
inclusion criteria: * patients should be systemically healthy with moderate to severe chronic periodontitis of more than 4 mm probing depth in at least two sites in different quadrants. * patient should exhibit no known allergies * participants should have the ability to attend the hospital regular intervals. exclusion criteria: * pregnancy * nursing * hypertension * patient with chronic diseases such as diabetes mellitus or rheumatoid arthritis. -participants should not be under antibiotics and\\or had receive any periodontal therapy for the last 6 months. * participants should not taking drugs that could affect the state of the gingival tissues. * participants must not be undergoing orthodontic therapy, caries free * participants must not be using any other supplemental plaque control measures like mouthwashes. * participants should not have the habit of taking alcohol, smoking or chewing tobacco and do not suffer from any systemic disease.
dose escalation & expansion study of oral vrx-3996 & valganciclovir in subjects with ebv+ lymphoid malignancies

Conditions: Epstein-Barr Virus-Associated Lymphoma; Lymphoproliferative Disorders

Summary: a two part, phase 1b/2 study to define a recommended phase 2 dose of vrx-3996 in combination with valganciclovir (phase 1b) designed to evaluate the efficacy of this combination in relapsed/refractory epstein-barr virus associated lymphoma (ebv+ lymphomas).

the purpose of this study is to determine whether vrx-3996 in combination with valganciclovir is safe, determine the side effect profile, and to determine whether this therapy may help patients with ebv-related lymphomas. the study has two phases. goals of the first phase include determining a safe and tolerable dose that can be administered in phase 2. goals of the second phase include further evaluating the safety and tolerability of vrx-3996 in combination with valganciclovir, evaluating how the drugs are metabolized in the body, evaluating response rates and other exploratory objectives that will help the researchers evaluate how these drugs work in the body. participants will receive daily oral doses of the two study drugs and will have multiple study visits where they will have blood collected, physical examinations, and other medical monitoring. following completion of the ph2, the study will enroll additional patients into a tablet pharmacokinetic (pk) cohort to investigate the pk parameters of the tablet formulation.

Eligibility criteria:
key inclusion criteria: * relapsed/refractory, pathologically confirmed epstein-barr virus positive (ebv+) lymphoid malignancy or lymphoproliferative disease * absence of available therapy with reasonable likelihood of cure or significant clinical benefit * adequate hematologic, hepatic and renal function as defined by laboratory assessment key exclusion criteria: * known primary central nervous system (cns) lymphoma * known cns metastases or leptomeningeal disease unless appropriately treated and neurologically stable for at least 4 weeks * active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy * refractory graft versus host disease (gvhd) not responding to treatment * known active hepatitis b virus infection * circulating hepatitis c virus on quantitative polymerase chain reaction (qpcr) * known history of human herpes virus (hhv)-6 chromosomal integration * known history of hiv infection

Keywords: ebv-associated peripheral t-cell lymphoma ebv-associated angioimmunoblastic t-cell lymphoma ebv-associated diffuse large b-cell lymphoma ebv-associated post-transplant lymphoproliferative disorder ebv-associated extranodal nk/t-cell lymphoma ebv-associated hodgkin lymphoma ebv-associated non-hodgkin lymphoma
antibacterial activity of urea against ocular bacteria

Conditions: Urea in Blood; High

Summary: antibacterial properties of urea was tested against 35 isolates from ocular infections.

in vitro susceptibility testing was performed with commercially available antibiotic discs, homemade urea discs saturated with urea solution at a concentration of 96 mmol. the weight of urea in one drop = 0.37 mg, in one ml = 10.34 mg (5 microliter/ disc) discs and combined discs (antibiotic discs to which urea solution was added). combined discs provided better in vitro susceptibility results than antibiotics alone. scanning electron micrographs of bacterial isolates incubated overnight with urea solution showed marked disruption of bacterial aggregative patterns and irregularities of their cell walls. western blotting showed marked reduction in total proteins in bacterial isolates incubated overnight with urea solution. these findings may explain the possible mechanisms for antibacterial activity of urea solution as a result of protein denaturation.

Eligibility criteria:
inclusion criteria: * ocular infection exclusion criteria: * local antibiotics treatment
tendon transfer rotator cuff tear

Conditions: Rotator Cuff Tears

Summary: this is a prospective randomized study on using muscle tendons to repair tears of the muscles on the shoulder. there are 3 muscles covering the shoulder joint- supraspinatus, infraspinatus and subscapularis. large tears involving these muscles can be treated by using some muscle from another location of the body known as tendon transfer techniques. these muscle tendons may be from the lower back (latissimus dorsi), upper pack (lower trapezius) or chest (pectoralis). there are currently no studies to show which tendon transfer technique has better outcomes. this study comprises two trials and a total of 84 participants would be enrolled. each trial comparing the patient reported outcomes between two tendon transfer techniques. large tears involving the supraspinatus and infraspinatus would be repaired using either the latissimus dorsi technique or lower trapezius technique. 21 patients would be randomly assigned to either groups. the second trial would be comparing the latissimus dorsi technique and pectoralis technique in large tears of the subscapularis muscle. another 21 patients would be randomly assigned to either groups. the investigators are studying to see if the lower trapezius and pectoralis transfer techniques for muscle tear repairs would have better post-surgical outcomes compared with latissimus dorsi transfer technique. for both trials, participants would be followed up for 2 years and post-surgical outcomes would be compared between treatment groups.


Eligibility criteria:
inclusion criteria: * subjects must have massive, irreparable tear of the posterior-superior rotator cuff * subjects between 18 years and 65 years (≥ 18 and ≤ 65 years of age). * diagnosis of no to minimal glenohumeral arthritis- hamada 1 and 2 * subject with irreparable subscapularis tendon tear (arms 3 and 4 only) exclusion criteria: * subjects having severe glenohumeral arthritis * history of prior tendon transfer * axillary nerve injury * deltoid deficiency * subjects with pseudo paralysis * history of post-operative deep shoulder infection * non-english-speaking subjects. * subject has any condition, that in the opinion of the investigator, would prevent them from completing this study * subject with irreparable subscapularis tendon tear (arms 1 and 2 only)

Keywords: massive rotator cuff tears tendon transfer rotator cuff tears tendon transfer techniques
analyzing composition and lubrication properties of synovial fluid

Conditions: Knee Osteoarthritis; HA Injection; One Injection Per Week for Five Week; Synovial Fluid Composition; Synovial Fluid Lubrication

Summary: to analyze the relationship between composition of synovial fluid and its lubrication properties

patients suffering from serious arthritis may receive the artificial joint replacement surgery. comparing to the articulation of articular cartilage, the artificial joint undergo a boundary lubrication in which a thin layer of synovial fluid molecules is formed between the artificial joint materials. therefore a larger wear rate is observed in the artificial joint system. researchers have devoted themselves to modifying the artificial joint materials in order to reduce the wear phenomena. we first propose that modification the lubrication by adding effective lubricating molecules may help to reduce the wear of artificial joint. however, there still lacks fundamentally understanding of the artificial joint lubrication mechanism under synovial fluid. hence, we plan to investigate the boundary lubrication mechanism of synovial molecules, such as albumin, globulin, hyaluronic acid, and lipid in the first year. we would like to obtain the adsorption behaviors of the single molecules as well as multiple molecules on the surfaces of artificial joint materials by experiments. molecular dynamics simulation will also be performed to gain the knowledge of adsorption energy and possible conformation change of the molecules. in the second year, the tribological heat and mechanical effects on the synovial molecules will be studied. the analysis platform will be established to perform the composition and properties measurement of the synovial molecules. in the third year, we will further discuss the effect of the synovial molecules transformation on the surrounding cells and tissues. their influences on the tribological and biochemical behaviors will be investigated.

Eligibility criteria:
inclusion criteria: * patients who are going to receive ha injection of one or two knees exclusion criteria: * patients whose quantity of synovial fluid is not enough to be drawn

Keywords: osteoarthritis ha synovial fluid lubrication
high resolution 3d diffusion-weighted breast mri

Conditions: Breast Cancer; Metastatic Breast Cancer

Summary: the purpose of this study is to determine how well a new mri technique called "high resolution 3d diffusion-weighted breast mri" detects breast cancer.

the objective of this study is to assess the diagnostic accuracy of a new non-contrast mri method for breast cancer detection. the study design is a single arm observational study. the new technique will be added on to the standard sequences that a women undergoes during a breast mri. the resulting images will be compared with her standard breast mri images, and with results of subsequent pathology.

Eligibility criteria:
inclusion criteria:1. patient scheduled for contrast-enhanced breast mri to image possible breast cancer. 2. female 3. age \>18 exclusion criteria:1. lactation 2. pregnancy 3. patient undergoing chemotherapy. these patients are excluded because chemotherapy changes the biology of breast cancers. since the ultimate objective of the research is to develop a new imaging method for breast mri screening (detection of previously unknown tumors), results in treated tumors would not be relevant. including treated tumors could yield a misleading assessment of the performance of the new method since treated tumors have different imaging characteristics than de novo tumors. 4. patient scheduled for pre-operative chemotherapy. these patients are excluded if they are going to be treated only on the basis of fine needle aspiration. the project seeks to correlate all tumors detected with standard histopathology of their untreated neoplasm. this exclusion criteria will be very unusual because most patients planning neoadjuvant chemotherapy do so on the basis of a pre-chemo core needle biopsy, which provide adequate histopathologic proof necessary for enrollment.