Kornimate/medical-research-clean huggingface dataset:
relationship between dysfunctions of movement in the lower back and pelvis with overuse injuries in handball players

Conditions: Dysfunction;Joint; Overuse Injury

Summary: the aim of this study is to assess the relationship between the presence of overuse injuries and failure to control of movement in those areas. for this, participants will perform some tests related to movement dysfunction lumbar-pelvic area to check for faults in one or more movement planes.

handball is considered a high intensity sport even though the 70% of the time the game is standing or walking. the large number of repetitions of high intensity activities such as sprinting or jumping, associated with physical contact with opposing players, make this sport in a physically demanding activity. furthermore, overuse injuries have been widely described but poorly quantified. in addition, is necessary to know the influence of static lumbar-pelvic position in low back pain and its correlation with stability. not only strength is important for a good quality of movement, there should also be a specific muscle activation in order for a correct motor pattern. this coordinated action must be i just by the action of muscles agonists, antagonists and synergists.the aim of this study is to assess the relationship between the presence of overuse injuries and failure to control of movement in those areas. for this, participants will perform some tests related to movement dysfunction lumbar-pelvic area to check for faults in one or more movement planes.

Eligibility criteria:
inclusion criteria: * players from the first team * without injury that does not allow movement tests exclusion criteria: * spinal cord injury or tumor, myelopathy, neuropathy and spondylitis and spondylolisthesis in the lumbar spine. * tumors or major injuries in the knee or hip.
telemedicine enabling patients in self-care behaviors

Conditions: Arrythmia

Summary: the purpose of the study is to see if monthly telemedicine computer visits (visits using the computer) improve the time it takes to identify and treat an arrhythmia. the second purpose is to see if monthly telemedicine computer visits improves the participant's understanding of the arrhythmia and improves how the participant feels with daily activities.

study will utilize the telemedicine group and the standard visit group (30 patients each group) to determine endpoints: 1. time of recognition, time of diagnosis and time of intervention for arrhythmia. these times will be noted for each patient in each group and look for any difference in these times based upon gaining information from telemedicine visits versus 6 month follow up visit. 2. three surveys of patient self efficacy of medications, activity, and arrhythmia knowledge utilizing three surveys in each group. surveys will be answered at the start of the study and end of the study by every patient within each group. surveys: muse- medication understanding and self efficacy tool shortened fses- functioning self efficacy scale asta- arrhythmia specific symptoms and health related quality of life in connection with heart rhythm disturbance

Eligibility criteria:
inclusion criteria: * read and speak english * 18 years of age or older * have a cardiac arrhythmia diagnosis * are willing to participate in the study and answer a pre and post survey. exclusion criteria: * any difficulty in understanding the study * does not have internet or a cell phone data plan * any life threatening arrhythmias * objection to working with nurse practitioners and physician assistants

Keywords: telemedicine self-care
the effects of pregnancy classes and contributing factors to postpartum depression

Conditions: Postpartum Depression; Sleep Disorder; Breast Feeding; Self Esteem

Summary: it is recommended by the american college of obstetricians and gynecologists' committee on obstetric practice that all obstetricians screen each women for postpartum depression and anxiety with a validated instrument. although much effort is made, the contributing factors still lack in the literature due to its multi-factorial nature and complexity. in addition, the effects of prenatal education classes remain understudied. therefore, this study aims to demonstrate the prevalence, characteristics and contributing factors of the postpartum depression. in addition, the change in prevalence and characteristics of the postpartum depression among women who had prenatal classes and not will also be assessed.

specific and validated instruments will be performed to women in their 8th week of postpartum period. those instruments are: edinburgh postpartum depression scale (epds) female genital self-image scale (fgsis) insomnia severity index (isi) breast-feeding efficacy scale short form (bses-sf) beck depression scale

Eligibility criteria:
inclusion criteria: * all women in the puerpera period (who gave consent) exclusion criteria: * none.

Keywords: postpartum depression sleep disorder genital self-image breast-feeding prevalence
early detection of pancreatic cancer

Conditions: Pancreatic Cancer

Summary: the purpose of this study is to enable non-invasive early detection of pancreatic cancer in high-risk populations through the establishment of a machine learning model using plasma cell-free dna fragmentomics. plasma cell-free dna from early stage pancreatic cancer patients and healthy individuals will be subjected to whole-genome sequencing. features, such as cell-free dna fragmentation, copy number variations and the status of kras gene mutation, will be assessed to generate this model.

the incidence of pancreatic cancer is insidious. most patients were in advanced stage when diagnosed and could not be cured by surgery. early diagnosis of pancreatic cancer through screening is so important. early screening detection projects derived from liquid biopsy technology are not only limited to circulating dna methylation markers, but have developed into multi-dimensional indicators for joint evaluation. this large-scale early detection study will randomly enroll 260 stage i/ii/iii pancreatic patients, 80 patients with pancreatic benign diseases and 156 age- and sex-matched healthy individuals upon providing written informed consent. plasma samples will be collected and extracted cell-free dna will be subjected to whole genome sequencing. we aimed to incorporate genome-wide copy number variations, cell-free dna fragmentomics, and status of kras gene mutation into the development of a multimodal biomarker-based prediction model.

Eligibility criteria:
inclusion criteria: * age minimum 18 years * participants must have histologically and/or cytologically confirmed stage i/ii/iii pancreatic cancer * full access to the patients' clinical and pathological records * ability to understand and the willingness to sign a written informed consent document * non-cancer controls are sex- and age-matched individuals without presence of any tumors or nodules or any other severe chronic diseases through systematic screening exclusion criteria: * participants must not be pregnant or breastfeeding * participants must not have prior cancer histories or a second non-pancreatic malignancy * participants must not have had any form of cancer treatment before enrollment or plasma collection, including surgery, chemotherapy, radiotherapy, targeted therapy and immunotherapy * participants must not present medical conditions of fever or have acute or immunological diseases that required treatment 14 days before plasma collection * participants who underwent organ transplant or allogenic bone marrow or hematopoietic stem cell transplantation * participants with clinically important abnormalities or conditions unsuitable for blood collection * any uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, myocardial infarction, major seizure disorder, unstable spinal cord compression, superior vena cava syndrome, or psychiatric illness/social situations that would limit compliance with study requirements or influence patient signing the written informed consent
next generation home vision assessment

Conditions: Amblyopia; Vision; Low, One Eye (Other Eye Normal); Pediatric Disorder

Summary: comparison of live remote paediatric digital vision testing outcomes versus face to face appointments in orthoptic clinic

study overview the "next generation home vision assessment" study aims to evaluate the feasibility and accuracy of conducting vision assessments at home using a web-based platform. this prospective, non-interventional, multi-center study will compare home-based vision tests with traditional hospital-based assessments. study background the covid-19 pandemic has significantly limited patients' ability to attend in-person eye clinic appointments, impacting vision assessments and management. ramifications in delays continue to have an impact. study rationale this study seeks to validate home-based vision assessments against standard in-person evaluations to ensure patients can be effectively monitored and managed remotely. the use of a web-based platform for vision tests could offer a reliable alternative, reducing hospital visits and maintaining care standards. objectives and endpoints primary objective: to compare the accuracy of home-based visual acuity tests to hospital-based assessments. secondary objectives: to evaluate other aspects of visual function (e.g., visual fields, color vision, contrast sensitivity) and measure patient engagement and test duration. study design type: prospective, non-interventional participants: adults and children attending hospital eye services sample size: 360 completed assessments duration: minimum of 6 months study procedure participants attending hospital eye services will be recruited and provided with a patient information leaflet. those willing to participate will undergo a visual acuity test +/- additional vision tests (secondary outcomes) during a video consultation. hospital-based assessment results will be compared to home-based test results to determine accuracy.

Eligibility criteria:
inclusion criteria - patients attending hospital eye services will be eligible for enrolment. age: less than 90 years old english speakers, as no available resource for translation services. parents / patients must be able to provide consent patient must be able to communicate what he / she sees on a vision assessment chart. must have access to smartphone, tablet or home computer that can run video conferencing platforms. exclusion criteria non english speakers or lack of ability to consent inability to communicate what is seen on a chart, or inability to complete a preferential looking visual acuity test inability to connect to a video conferencing platform.

Keywords: teleophthalmology remote consultations amblyopia paediatrics telemedicine digital health
hip strengthening and manual therapy for heel pain patients

Conditions: Plantar Fasciitis

Summary: the purpose of this study is to compare the effects of manual therapy and of manual therapy associated with hip strengthening in the recovery of patients with heel pain. heel pain decreases function, balance, walking and can cause change in the movement pattern. this alterations can induce a deficit in motor control of other structures as knee and hip. there is an importance to compare the effects of manual therapy and manual therapy associated with hip strengthening on the recover of patients with heel pain.

after the initial assessment and data collection, participants will be randomly assigned to one of two intervention groups. randomization will be held electronically in http://graphpad.com/quickcalcs/index.cfm site by simple random sampling. patients will be treated for a maximum of 10 sessions, each session lasting about 40 minutes and each week two sessions. the maximum duration of treatment is 3 months. a physical therapist will be responsible for the screening of eligible patients and the random allocation of participants a second professional will be responsible for physical therapy initial and final evaluation and will be blind to the interventions. a third physical therapist will perform the interventions. the physiotherapist in charge of intervention will be blind to the initial and final evaluation.

Eligibility criteria:
inclusion criteria: * patients with heel pain, that increases on the first steps after a period without activity and with long periods on standing position, regardless of age and gender and that didn't went under any physiotherapeutic treatment in the last 3 months. exclusion criteria: * patients who have a history of surgery on the lower limb on the past 6 months; patients with bilateral heel pain; patients under psychiatric treatment; patients that went under a manual therapy scheme treatment for heel pain before; rheumatic syndromes; patients who receive some benefit labor or patients underage.

Keywords: manual therapy pain hip muscle strength
subjective comfort with multipurpose care solutions in soft contact lens wearers

Conditions: Myopia; Astigmatism; Refractive Error

Summary: the purpose of this study was to assess the comfort of opti-free replenish in soft contact lens wearers.


Eligibility criteria:
inclusion criteria: * currently wearing silicone hydrogel contact lenses on a daily wear basis; * currently using opti-free replenish contact lens solution; * generally healthy; * normal ocular health; * willing to follow study procedures and visit schedule; * sign informed consent and privacy document; * other protocol-defined inclusion criteria may apply. exclusion criteria: * use of additional lens cleaners; * known sensitivities to any ingredient in either test article; * systemic or ocular disease or disorder that would negatively affect the conduct or outcome of the study; * history of ocular surgery/trauma within the last 6 months; * any topical ocular or systemic antibiotics within 7 days of enrollment continuing throughout the study; * participation in any other ophthalmic drug or device clinical trial within 30 days of enrollent; * other protocol-defined exclusion criteria may apply.

Keywords: soft contact lenses multi-purpose solution
comparison of combigan two times daily (bid) versus simbrinza three times daily (tid)

Conditions: Glaucoma; Ocular Hypertension

Summary: to compare combigan two times daily (bid) vs simbrinza three times daily (tid) in subjects currently being treated with latanoprost for open-angle glaucoma or ocular hypertension. both of these drugs are currently fda approved as combination therapy for patients with open-angle glaucoma or ocular hypertension. the purpose of this clinical trial would be to assess which treatment, if either, is superior in lowering intraocular pressure (iop). a secondary objective is to assess the tolerability of each drug.


Eligibility criteria:
inclusion criteria: * open-angle glaucoma or ocular hypertension * currently treated with latanoprost for min of 6 weeks * male or female 18 yrs and older * best corrected visual acuity 20/100 or better in both eyes * pachymetry \>470 and \< 640 * women of childbearing potential must have a negative urine pregnancy test at the screening/baseline visit * patient willing and capable of providing informed consent exclusion criteria: * c/d \> 0.8 * visual field loss, which in the opinion of the investigator is functionally significant * current use of ocular steroids * concurrent significant active ocular disease history (within 3 months prior to screening) of ocular laser, intraocular, filtering or refractive surgery or planned ocular surgery of any kind during study participation * change within prior 30 days or anticipated change in any systemic medication that is known to affect iop * uncontrolled systemic disease * significant ocular hyperemia at baseline * prior glaucoma procedure within 3 months * females who are pregnant, nursing, or planning a pregnancy or who are of childbearing potential and not using a reliable method of contraception * known allergy or sensitivity to any study medication * asthma or any other known medical condition that the investigator feels would put patient at increased risk from any of the study medications * current enrollment in an investigational drug or device study or participation in such a study within 30 days prior to screening

Keywords: open-angle glaucoma ocular hypertension
testing mst to improve adherence among youth with chronic poor metabolic control

Conditions: Type 1 Diabetes

Summary: the protocol is a randomized clinical trial providing multisystemic therapy (mst), an intensive home-based family psychotherapy intervention, to a group of urban adolescents with poorly controlled type 1 diabetes and their families.

substantial data exists to demonstrate that improving metabolic control in persons with type 1 diabetes mellitus (t1dm) can delay the onset of diabetes complications and reverse some existing complications as well. unfortunately, those adolescents with t1dm who are at highest risk for diabetes complications are often the most resistant to hospital based care and traditional education/ supportive interventions. they are also faced with multiple barriers to improved metabolic control, which may include lack of knowledge about diabetes, family disorganization and disengagement, high levels of stress and an unhealthy lifestyle. multisystemic therapy (mst), a flexible and home-based therapeutic intervention originally designed for use with mental health populations, seems to be a promising approach to providing diabetic adolescents with the ability to engage in consistent and attentive illness management. the study recruited a sample of 127 adolescents in poor metabolic control and randomly assigned them to either the treatment intervention, mst plus standard medical care, or standard medical care alone. families randomized to mst received intensive, home-based family therapy for approximately six months. families completed data collection at baseline and then again at 7, 12 18 and 24 months after study entry.

Eligibility criteria:
inclusion criteria: * a current hemoglobin a1c(hba1c) of \>8.0% * an average hba1c of \>8.0% during the past year * diagnosed with type 1 diabetes for at least one year * reside in the metro detroit tri-county area exclusion criteria: * severe mental impairment/thought disorder * non-english speaking patient/parent * co-morbid major medical condition such as cystic fibrosis

Keywords: insulin dependent diabetes mellitus family therapy adolescents
postoperative analgesia in children after propofol anesthesia

Conditions: Postoperative Pain

Summary: the investigators hypothesize that patients anesthetized with sevoflurane have more pain, postoperatively, than those anesthetized with propofol.

in a randomize, prospective, double-blind study, the subjects are 100 premedicated children, aged 3 to 6 years, who undergo one type of surgical procedure, hernia repair surgery. anesthesia is maintains with propofol anesthesia (group p, n=50) or with sevoflurane anesthesia (group s, n=50). and fentanyl administered during surgery. faces pain scale (fps) is use to assess pain severity.

Eligibility criteria:
inclusion criteria: * patient is 3- 6 years old * patient is scheduled for hernia repair surgery at university clinical center of kosovo patients is asa i/ii patient meets criteria to receive either propofol or sevoflurane anesthesia patient's parent/guardian provides written consent exclusion criteria: * allergy to any of the drugs * preoperative anxiety * postoperative agitation * asa physical status \>ii

Keywords: propofol sevoflurane postoperative pain children
fluoxetine in pediatric body dysmorphic disorder

Conditions: Body Dysmorphic Disorder

Summary: this trial will study the effectiveness of the medication fluoxetine for children and adolescents ages 16 and younger with bdd who qualify.

bdd usually begins in childhood or adolescence, but its treatment in pediatric populations has not been investigated. recent data suggests that adults with bdd may respond to serotonin reuptake inhibitors (sris) such as fluoxetine (prozac). preliminary findings from case reports suggest that sris may also be effective in the treatment of bdd in children and adolescents. this study is the first large-scale, double-blind, placebo-controlled medication trial of fluoxetine for children and adolescents with bdd. participants should be aged 16 or younger. participation in this trial will last approximately 14 weeks.

Eligibility criteria:
inclusion criteria: * male or female children and adolescents aged 16 and younger * bdd or its delusional variant present currently and for at least 6 months prior to the study * ability to communicate meaningfully with the investigators and competent to provide written assent exclusion criteria: * presence of schizophrenia or bipolar disorder * recent suicide attempt or suicidal ideations that warrant hospitalizations * previous allergic reaction to fluoxetine * history of a seizure disorder

Keywords: body dysmorphic disorder bdd bdd treatment delusionality variant ocd