Kornimate/medical-research-clean huggingface dataset:
improving health behaviors for pediatric cancer survivors

Conditions: Cancer

Summary: the objective of this study is to examine the efficacy of harvesting hope for kids (hh4k), a biobehavioral intervention delivered in the context of a university-based, cancer survivor garden, to increase produce intake and physical activity in survivors and caregivers.

advances in treatment have led to a rapidly growing population of over 388,500 survivors, with 13,500 new survivors expected annually. however, chronic or long-term side effects (e.g., secondary malignancies, metabolic syndrome, cardio-pulmonary toxicities) can reduce quality of life and lead to premature death. the investigators propose that diet and fitness are two critical factors for healthy survivorship given their broad impact on late effects like obesity, fatigue, and metabolic syndrome. despite the promise of comprehensive lifestyle interventions for children who are overweight or obese, research with survivors is limited by small samples and inconsistent effects. novel research supports a key role for the gastrointestinal (gi) microbiome in regulating weight and health outcomes, yet no studies have examined the "obesogenic" microbiome in the context of lifestyle interventions for survivors of childhood cancer. the objective of this rct is to examine the efficacy of harvesting hope for kids (hh4k), a biobehavioral intervention delivered in the context of a university-based, cancer survivor garden, to increase produce intake and physical activity in survivors and caregivers. families will be randomized to participate in hh4k or enhanced usual care. dietary patterns, physical activity, cardiometabolic indices, family outcomes, and gi microbiome will be assessed and the hh4k group will demonstrate greater improved than enhanced usual care.

Eligibility criteria:
inclusion criteria: * 8-12 years of age * previously diagnosed with any type of pediatric cancer * within 5 years post-treatment for pediatric cancer * fluent in english, with at least 1 fluent parent * living within 75 miles of the medical center exclusion criteria: * significant developmental disorder or cognitive difficulties that would interfere with children and caregivers completing questionnaires * referral to hospice or at end of life.

Keywords: behavioral obesity neoplasm
effect of garlic tablet some indicators related to atherosclerosis

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to determine whether garlic in adjunct to conventional medical treatment is effective in improving carotid intima media thickness (cimt), flow mediated dilation (fmd) and plasma lipid profile or c-reactive protein of coronary artery disease (cad) patients.


Eligibility criteria:
inclusion criteria: * angiography confirmed coronary artery disease * lack of consistent use of the garlic in the last month exclusion criteria: change in type of medication during study

Keywords: cad cimt fmd
biomechanical aligment of lower limb as a predictor for stress urinary incontinence in postmenopausal women

Conditions: Stress Urinary Incontinence

Summary: this study will be conducted to assess biomechanical alignment of lower limb as a predictor for the stress urinary incontinence in the postmenopausal women. 300 postmenopausual women will be selected suffering from stress unrinary incontinence . their age ranges from 60 to 70 years old. their bmi is not exceeding 30 kg/m2.

in this study 300 postmenopausual women will be selected suffering from stress unrinary incontinence. their age ranges from 60 to 70 years old. their bmi is not exceeding 30 kg/m2. different methods of assessment will be used as : data recording sheet, weight-height scale, goniometer ,x ray radiography ,transabdominal ultrasound and perineal ultrasound. data recording sheet: it will be used to record data of each woman before starting this study. weight-height scale: it will be used to measure weight and height of each woman before starting this study. goniometer: it will be used to document the initial and the subsequent range of motion for ankle joint for each woman. transabdominal ultrasound: it will be used for measurement of post-void residual volume pvr for each woman which is the volume of urine left in the bladder after micturition . perineal ultrasound: it will be used to assess the posterior urethrovesical angle for each woman . x-ray radiography: lateral pelvic radiographs will be taken for each woman in order to objectify the individual pelvic tilt. inclusion criteria include : subjects will be postmenopausal women complaining from stress urinary incontinence participants age will range from 60-70 years.their bmi will not exceed 30 kg/m2. exclusion criteria: previous history of cancer and radiotherapy, any disease that could interfere with the participation, lower urinary tract infections( manshadi f. etal ) musculoskeletal problems; previous major abdominal or pelvic surgery; severe diseases; diabetes mellitus, a body mass index \>30 kg/m2; intraureterine device implantation, pelvic organ prolapse and menopause (cerruto m etal.)

Eligibility criteria:
inclusion criteria: subjects will be 300 postmenopausal women suffering from stress urinary incontinence participants age will range from 60-70 years.their bmi will not exceed 30 kg/m2 exclusion criteria: * previous history of cancer and radiotherapy, any disease that could interfere with the participation, lower urinary tract infections( manshadi f. etal ) musculoskeletal problems; previous major abdominal or pelvic surgery; severe diseases; diabetes mellitus, a body mass index \>30 kg/m2; intraureterine device implantation, pelvic organ prolapse and menopause (cerruto m etal.)

Keywords: stress urinary incontinence pelvic tilt ankle position
effect of removal of double antibiotic paste on post operative pain

Conditions: Effects of the Elements

Summary: recruited patients with necrotic pulp after application of double antibiotic paste are assigned to group (xp endo finisher file) and group( passive ultrasonic irrigation) and group (conventional syringe irrigation with side vented needle) to remove intracanal medication and record postoperative pain afterwards.

the investigator will recruit patients who are found eligible to the criteria, double antibiotic paste will be inserted inside the canals. after 7 days, patients will be randomly assigned to either removal of intracanal medication using, the xp-endo finisher file, passive ultrasonic irrigation (pui) and conventional syringe irrigation with side vented needle. after the visit, patients will be asked to record post operative pain by visual analog scale)in a given sheet

Eligibility criteria:
inclusion criteria: * medically free patients. * patient's age between 20-50 years. * both sexes. * necrotic pulp as indicated by thermal or electric pulp testing. * no history of previous endodontic treatment of the tooth. * enough crown structure for adequate isolation. exclusion criteria: * pregnancy or lactation * medically compromised patients * previous endodontic therapy of the affected tooth. * teeth diagnosed with vital pulp. * teeth with periodontal pocket more than 3mm deep. * teeth with abnormal anatomy or calcified canals. * teeth with caries below the bony level (non-restorable tooth). * immature teeth with open apices.
myomectomies:tumor characteristics and clinical implications

Conditions: Uterine Myomectomy; Genetics; Quality of Life; Gynecologic Surgical Procedures

Summary: this project focuses on myomectomy patients in reproductive age. the aim is to study both the molecular characteristics of uterine fibroids and to characterize the clinical effects of surgical treatment. patient series is mainly retrospective and consists of individuals who have undergone myomectomy at helsinki university central hospital (huch) during 2009-2015. in addition, the investigators have started a prospective sample collection starting in october 2015, collecting samples from myomectomies. clinical data sources include medical records, specific questionnaires and a quality of life -questionnaire filled by patients.


Eligibility criteria:
inclusion criteria: * uterine leiomyoma * seeking for surgery exclusion criteria: * language proficiency in finnish, swedish or english
intra oral scanning of edentulous arches

Conditions: Edentulous Jaw

Summary: the aim of this study is to compare the influence of different palatal vault configurations on the accuracy and scan speed of io scans in cases of completely edentulous arches. the null hypothesis is that there is no difference in scanning time, and trueness and precision of io scans between class i, ii and iii palatal vault configurations.

a reference model will be created for each of the three groups with different palatal vault configurations. pvs material (dmg silagum, germany) will be used for impressions in a one-step process by an experienced operator, and type iv plaster (heraeus, germany) will be used to produce the models. these models will then bedigitized by an experienced operator using an extraoral scanner (trios 3; 3shape, copenhagen, denmark). the stl scan file of the maxillary model will be imported into cad software (meshmixer; autodesk, san rafael, ca, usa) to generate a reference file. reference markers will then be added to the digital files to aid the superimposition process during digital subtraction operations.for intraoral scans, the entire maxilla of each patient will be digitally captured using an intraoral scanner (trios pod, 3shape, copenhagen, denmark).according to iso standards, specifically iso 5725-1, the accuracy of digital impressions obtained with intraoral scanners (ios) will be evaluated according to two main parameters: trueness and precision.

Eligibility criteria:
inclusion criteria: * 1. full tooth loss in the maxilla; 2. absence of infectious diseases; 3. systemic good health; 4. age between 50 and 75 years; 5. willingness to cooperate throughout the data collection process exclusion criteria: * exclusion criteria included: 1. presence of any remaining teeth; 2. inability to comprehend the study's objectives and procedures; 3. palatal defect or lesion; 4. postoperative scarring on the palate; 5. limitations in mouth opening.
social support intervention for self-management of type 2 diabetes mellitus

Conditions: Diabetes Mellitus, Type 2

Summary: this study will assess the effect of a social support intervention for self-management of type 2 diabetes mellitus (dm2) in adults. this intervention is based on a medium-range nursing theory of individual and family self-management. findings will be evaluated using the nursing outcomes "self-management: diabetes" and "social support" from the nursing outcomes classification (noc).

diabetes mellitus is responsible for 1.6 million deaths a year, becoming one of the world's 21st century health emergencies. dm2 is the most frequent form of diabetes, accounting for 90% of all cases of this chronic condition. if this trend continues, by 2045 about 693 million people will have diabetes. people with chronic diseases have changing perspectives, in addition to suffering physical alterations, their psychological, emotional and social state is also compromised, presenting themselves as a need to modify lifestyle to improve prognosis, facing alterations in the ability to socialize and with death or a great loss. few studies comprehensively address these dimensions. the literature reports that dm2 self-control has a direct effect in improving clinical results, reducing complications and quality of life. therefore, the patient must make multiple decisions every day regarding diet, physical activity, glucose control, and medication compliance. however, intervention studies that seek to improve self-management behaviors in people with dm2 are characterized by emphasizing the transmission of knowledge and establishing compliance with prescribed treatments, but they do not address social and emotional elements such as social support. additionally, most of these interventions do not show the use of theoretical models that provide explanations of human responses to disease and other phenomena important to practice. studies using the nursing outcomes classification to assess the effect of social support interventions are scarce.

Eligibility criteria:
inclusion criteria: * adults over 18 years with a diagnosis of dm2, attending the outpatient diabetes consultation at the health care institution. * initial score less than or equal to 3 on the noc outcomes: self-management: diabetes and social support. exclusion criteria: * people with a score \<30 on the cognitive mini mental test. * other comorbidities reported by the patient or in the medical history that limit receiving the intervention (example: hearing loss, deafness, alzheimer's disease).

Keywords: nursing outcomes classification terminology self-management social support
bilateral erector spinae plane block for myofascial pain syndrome

Conditions: Myofascial Pain Syndrome

Summary: the investigators aimed to evaluate the effectiveness of bilateral erector spina plane block application in myofascial pain syndrome.

the investigators aimed to evaluate the effectiveness of bilateral erector spina plane block application in myofascial pain syndrome by comparing trigger point injection. group 1 only one time erector spinae plane block and group 2 once a week total three times trigger point injection. before the application, one week after application and one month after first application the investigators aimed to compare pressure pain threshold with algometer, visual analog scale score, short form-36 score, neck disability index score, beck depression scale score for the two groups. each group has 30 participants, total 60 participants included this study. the investigators planned to show that bilateral erector spinae plane block can be used as an effective and safe method in the treatment of myofascial pain syndrome, since it is easier to apply than other invasive procedures used in the treatment and has a very low complication profile.

Eligibility criteria:
inclusion criteria: * get a myofascial pain syndrome diagnosis * no invasive procedure for myofascial pain syndrome in the last 1 month * signing the informed consent form exclusion criteria: * cervical disc herniation * neck/shoulder, thoracal trauma or operation history * malignancy * kyphoscoliosis * inflammatory diseases (rheumatoid arthritis, ankylosing spondylitis...) * congenital vertebral anomalies * neck pain with neurological deficit * pregnancy * mental, psychogenic disorder * hematological diseases that cause bleeding and coagulation disorders * use of antiplatelet, anticoagulant and drugs that cause bleeding tendency * severe systemic infection such as sepsis and local infection at the intervention site * having an allergy to any of the drugs to be used

Keywords: erector spinae plane block myofascial pain syndrome trigger point algometer visual analog scale pain
effect of the pipac on the survival rate of patients with peritoneal carcinomatosis of gastric origin

Conditions: Carcinomatosis, Peritoneal

Summary: pressurised intraperitoneal aerosol chemotherapy is a new surgical technique, developed for the treatment of initially unresectable peritoneal carcinomatosis. the objective of this study was to compare the results of pipac associated with systemic chemotherapy with those of systemic chemotherapy alone in patients with gastric peritoneal carcinomatosis without metastasis other than peritoneal, and who performance status \<3.


Eligibility criteria:
inclusion criteria: * patients 18 years or over * patients with adenocarcinoma-type gastric non-resectable péritonéale carcinomatosis. * patients without metastasis other than peritoneal. * who performance status \<3 * patients treated either with pipac administered in alternation with systemic chemotherapy (pipac_chem) or by systemic chemotherapy alone (only_chem) * patient informed exclusion criteria: - patients opposed
advanced wireless, wearable sensors for continuous hemodynamic monitoring

Conditions: Congestive Heart Failure

Summary: percent agreement of vital signs monitoring between the experimental sensor and standard of care monitoring


Eligibility criteria:
inclusion criteria 1. patient's aged 18-65 2. patient's scheduled to undergo a trans-thoracic echocardiogram (tte) in an outpatient cardiology clinic or admitted to the cardiac care unit with a swan ganz catheter in place for continuous invasive hemodynamic monitoring exclusion criteria 1. patient's with fragile skin or skin conditions that would prevent them from having a sensor placed 2. patients undergoing exercise or drug induced cardiac stress test 3. patients with a visible wound at site of sensor placement 3.4. patients with structural or functional limitations to peripheral blood flow (known upper extremity peripheral arterial disease, use of vasopressors etc.).
apremilast pediatric study in children with active juvenile psoriatic arthritis

Conditions: Active Juvenile Psoriatic Arthritis

Summary: the study will aim to estimate the efficacy of apremilast compared with placebo in the treatment of juvenile psoriatic arthritis (jpsa) in pediatric participants 5 to less than 18 years of age.


Eligibility criteria:
inclusion criteria: * male or female participants 5 to \< 18 years of age at the time of randomization. * participant must have a confirmed diagnosis of juvenile psoriatic arthritis (jpsa) according to the international league of associations for rheumatology (ilar) edmonton revision (petty, 2001) classification criteria of at least 6 months duration: * arthritis and psoriasis, or * arthritis with at least 2 of the following: * dactylitis * nail pitting or onycholysis * psoriasis in a first-degree relative * active disease: at least 3 active joints. * inadequate response (at least 2 months) or intolerance to ≥ 1 disease-modifying anti-rheumatic drugs (dmard), (which may include methotrexate \[mtx\] or biologic agents). exclusion criteria: * exclusions per ilar edmonton revision (edmonton, 2001) criteria for jpsa include: * arthritis in an hla-b27-positive male with arthritis onset after 6 years of age * ankylosing spondylitis, sacroiliitis with inflammatory bowel disease, reiter's syndrome, acute anterior uveitis, or a history of one of these disorders in a first-degree relative * history of igm rheumatoid factor on at least 2 occasions at least 3 months apart * presence of systemic juvenile idiopathic arthritis (jia). * rheumatic autoimmune disease other than psoriatic arthritis (psa), including, but not limited to: systemic lupus erythematosus, mixed connective tissue disease, scleroderma, polymyositis, or fibromyalgia. * prior history of or current inflammatory joint disease other than psa (eg, gout, reactive arthritis, rheumatoid arthritis, ankylosing spondylitis, lyme disease).

Keywords: apremilast otezla® juvenile psoriatic arthritis inflammatory disorders
human placenta mesenchymal stem cells derived exosomes injection for treatment of complex anal fistula

Conditions: Fistula Perianal

Summary: the goal of this clinical trial is to learn if human placenta mesenchymal stem cells (msc)-derived exosomes work to treat complex perianal fistula in adults without crohn's disease. the safety of this treatment will also be learned. the main questions it aims to answer are: * does treatment with msc-derived exosomes lower the number of fistula recurrences in participants? * is treatment with msc-derived exosomes safe? we will compare treatment with msc-derived exosomes to the routine treatment which is fistulotomy (surgery to close the fistula) alone to see if msc-derived exosomes work better to treat complex fistula. participants will: * undergo fistulotomy plus msc-derived exosome injections or fistulotomy alone. * visit the clinic the week after surgery and then every 4 weeks for checkups and tests


Eligibility criteria:
inclusion criteria: * participants with complex perianal fistula * provided written informed consent exclusion criteria: * participants with any inflammatory bowel diseases * pregnant or lactating participants * participants with contraindications for surgery * participants with hepatitis * participants with uncontrolled diabetes * participants with alcohol or substance abuse

Keywords: fistula, perianal fistula, non-crohn's disease, exosome, mesenchymal stem cell, human placenta stem cell
peer mentors for adolescents in hiv affected families

Conditions: Adolescent Behavior; Health Behavior; HIV Seronegativity

Summary: this study will evaluate the effectiveness of a peer mentoring program designed for youths ages 9 to 15 whose parents or guardians are hiv infected. the program will focus on the youths' mental health, school performance, alcohol and drug use, personal and social behaviors, and behaviors that might expose them to hiv. the study is expected to enroll predominantly minority youth.

this study will conduct an efficacy trial of peer mentoring for a high-risk, predominantly minority population of 9- to 15-year-old youths whose parents are hiv infected. the study will also determine mechanisms (mediating variables) through which peer mentoring improves outcomes for the mentees, for example, consistency and continuity of relationship, teaching/role modeling, emotional support/empathy, advocacy, and behavioral reinforcement. after the conclusion of the efficacy trial, the study will continue through naturalistic longitudinal research for an additional 2 years in order to examine the long-term outcomes of peer mentoring. participants are randomized to either the peer mentoring program or a control condition (a recreation program). surveys are conducted at entry into the study, at 6 months, 1 year, and then annually for 2 years. youths will also participate in focus groups. the surveys and focus groups will assess the youths' psychological functioning, academic adjustment, alcohol and drug use, hiv risk behaviors, delinquent/violent behaviors, peer relationships, prosocial activities, and coping/problem-solving skills. the study will also evaluate family outcomes, including parent/guardian functioning and improved permanency planning.

Eligibility criteria:
inclusion criteria * hiv infected parent or guardian * no previous involvement in the mentoring program * adolescent assent * parental consent

Keywords: health behavior adolescent behavior peer mentoring
a comparative study minisling versus transobturator (tot)sling

Conditions: Female Stress Urinary Incontinence

Summary: a study to compare efficacy in surgical treatment for sui (stress urinary incontinence), tot with minisling.

eligibility criteria was : female stress urinary incontinence

Eligibility criteria:
inclusion criteria: * clinical and urodynamic diagnosis of sui in patients between 18 and 90 years exclusion criteria: * postvoid residual urine volume more than 100 ml, coagulation disorders, current urinary tract infection, sequelae of previous radiation therapy of the pelvis, anticoagulant therapy, vulvovaginitis, and anesthesia contraindication

Keywords: urodynamic stress urinary incontinence minisling ophira™ unitape™