Kornimate/medical-research-clean huggingface dataset:
this is an open-label study to evaluate fesoterodine plus "your way" patient support plan in patients with symptoms of overactive bladder

Conditions: Overactive Bladder

Summary: the primary objective of the study is to assess the level of medication adherence observed among subjects receiving a specific combination of education and support materials (yourway plan) along with a prescription for fesoterodine.

this is a non-interventional, observational study. study investigators will recruit symptomatic, fesoterodine-naïve subjects when they present with oab symptoms during regularly-scheduled physician visits fesoterodine-naïve subjects with oab symptoms present during regularly-scheduled physician visits

Eligibility criteria:
inclusion criteria: * male or female outpatients \>=18 years old * eligible for receiving toviaz 4mg or 8mg qd treatment based on the approved us label. exclusion criteria: * female subjects who are pregnant, lactating, or who are intending to become pregnant within 28 days after the completion of the study (use of contraceptives is not required to participate in the study) * have participated in any other studies involving study drugs within 30 days prior to entry in the study * subjects who have previously taken fesoterodine.

Keywords: overactive bladder incontinence adherence behavioral interventions
psychoeducation in patients who diagnosed with schizophrenia

Conditions: Quality of Life; Well-Being; Compliance, Treatment

Summary: people with schizophrenia are faced with social problems such as repeated hospitalizations, stigma with lack of social skills, unemployment, lack of necessary and adequate health care and education due to lack of adequate care in the community they live in. it is known that psychoeducation practices aimed at developing social skills in schizophrenia give patients new skills and these skills continue for many years. this study aimed to determine the effect of group psychoeducation that focused on social skill development on treatment adaptation, quality of life and well-being in schizophrenia patients and the interaction between these variables over time.

the aim is to determine the effect of group psychoeducation that focused on social skill development on treatment adaptation, quality of life and well-being in schizophrenia patients and the interaction between these variables over time. the study was conducted with 42 schizophrenia patients (n=21 intervention group; n=21 control group) using a quasi-experimental research design. patients were evaluated using a pre-test, post-test, monitoring test, "medication adherence rating scale (mars)", "quality of life scale for schizophrenia (qlss)" and "flourishing scale" (fs). the measurements were taken 3 times: pre test, post-test and 3-months post-test.

Eligibility criteria:
inclusion criteria: * volunteering * being 18 and over being literate * having been diagnosed with schizophrenia for at least three months * taking oral antipsychotics * being in remission. exclusion criteria: * being in an acute period of exacerbation * actively using alcohol or psychoactive substances * having mental retardation or dementia * having another psychiatric illness that makes it impossible to cooperate.

Keywords: schizophrenia psychoeducation compliance to treatment quality of life well-being
laparoscopy for endometriosis in obese patients

Conditions: Endometriosis; Obesity

Summary: evaluation of surgical outcomes of endometriosis laparoscopic surgery in obese patients.

obesity may influence surgical variables such as operative time, laparotomic conversion rate and intraoperative and postoperative complication rate. moreover, it might influence the hospital length of stay. for that reason, the study aims to compare a group of obese patients with a non-obese group of patients about these topics.

Eligibility criteria:
inclusion criteria: * obese patients undergoing endometriosis laparoscopic treatment * obteined informed consensus

Keywords: endometriosis obesity laparoscopy
long-term assessment of the safety and performance of the nuvasive simplify disc

Conditions: Cervical Disc Disease; Degenerative Disc Disease

Summary: a prospective, multicenter post-market clinical follow-up study to evaluate the 10-year long-term safety and effectiveness of the simplify disc in subjects who were enrolled in the post approval study (nct04630626).


Eligibility criteria:
inclusion criteria: 1. subject was enrolled in the simplify disc post approval study (nct04630626) at a participating study site 2. subject understands the conditions of enrollment and is willing to sign an informed consent form to participate in the study exclusion criteria: 1. subject had an ssi at the index level during the post approval study (nct04630626) 2. subject was withdrawn or withdrew consent to participate in the post approval study (nct04630626)
impact of a major organizational change on employee productivity and mental health

Conditions: Work Related Stress; Mental Health Issue; Work-related Illness

Summary: the study investigates the short- and long-term impact of a major organizational change on employee health and productivity. changes in organizations is a common aspect of modern work life in all sectors and public healthcare is no exception. however, emerging evidence suggests that organizational changes may be a potential stressor which can impact on employee well-being and contribute to stress-related health problems. using a large-scale natural experiment, the overall aim of the study is to investigate the impact of a major organizational change that took place during 2016-19 on employee health and productivity. in addition, we aim to identify groups that may be at increased risk of experiencing negative consequences of the reorganization. these at-risk groups can in turn be candidates for extended preventive measures when planning future major organizational changes.

the study relies solely on data from registries and the investigators have taken great care to ensure the validity of these data. below the main principles and procedures applied are outlined. for the data delivered from the hospital business intelligence (bi) database the investigators performed interviews with representatives from each workplace. this was done to ensure that the information about when a workplace underwent the organizational change was accurate, but also what type of organizational change the workplace experienced, how the workplace was organized in terms of departments/wards, and the number of employees at the workplace.the validity of the data supplied by statistics denmark relies on the comprehensive procedures to ensure data integrity at statistics denmark. all datamanagement by the investigators has been performed in the stata software package and all decisions are documented in program files (called "do-files" in stata teminology) to ensure a complete revision trail from the delivered raw data to the dataset used for the final analyses. the investigators have performed extensive data checks, both by tabulations, codebooks, and visual inspection of the data. to ensure against data management errors done by a single investigator when writing the program/do-files, all coding performed in the datamanagement phase has been reviewed by at least one of the other researchers.

Eligibility criteria:
inclusion criteria: * all employees at the hospital during 2011-2020 exclusion criteria: * employees who, after being informed of the study, opted out of participation (n=70)
comparison between steroid and different sites of botulinum toxin injection in the treatment of lateral epicondylalgia

Conditions: Tennis Elbow

Summary: the aim of the study is to compare two different injection sites of low dose botulinum toxin type a with steroid in treating lateral epicondylalgia.

lateral epicondylalgia or tennis elbow is a common painful elbow disorder with a prevalence of 1% to 3% in the general population and has a higher rate up to 14.5% in strenuous jobs. botulinum toxin type a injection was an emerging option in treating lateral epicondylalgia. in this study, the patients were randomly assigned into three groups: 1. botox-epic group received 20 units of botox injection into lateral epicondyle; 2. botox-tend group had 20 units of botox injected into tender point of muscles; 3. steroid group had 40mg of triamcinolone injected into lateral epicondyle. the aim of this randomized controlled study was to compare the effects of injection with corticosteroid and botulinum toxin type a via two different sites in patients with lateral epicondylalgia.

Eligibility criteria:
inclusion criteria: * spontaneous local pain over lateral epicondyle of the affected elbow for more than six months and failure to respond to previous physical therapy or oral medications, * local tenderness around the lateral epicondyle, and * pain elicited or aggravated by resisted contraction of the wrist or middle finger extensors. exclusion criteria: * local steroid injection within the past six months, * coexisting elbow arthritis or arthralgia, * previous trauma or surgery history over the lateral epicondyle, * pregnancy or lactation, and * other systemic, neuromuscular or bleeding disorders that are contraindicated to botox injection.
productivity study of presbyopia improvement in textile workers

Conditions: Presbyopia

Summary: to establish, using a randomized, controlled design, the impact of near vision correction on the productivity of presbyopic textile workers in china, as measured by the change of monthly income.

sustainable development is considered to be a major development strategy to meet rapid economic and social development in china. china is one of the biggest manufacturing hubs in the world. with the rapid development of economy, the health of manufacturing workers is closely related to productivity. in some low-income developing countries, studies have focused on improving the health of manufacturing workers to improve productivity .most of the studies focused on improving the nutritional intake of workers has a significant effect on improving work efficiency and productivity . as the global aging is becoming an critical issue for both health and economics, the health of the working population over the age of 45 is of greater concern in low - and middle-income developing countries. china has a workforce of 980 million people (aged 15 to 60). urban workers and blue-collar workers account for nearly 310 million. with the aging population increased, presbyopia is becoming more and more serious, and it also affects the labor group that needs to work in close proximity. studies have proved that refractive correction for tea pickers with old vision can effectively improve the yield of tea pickers and increase personal income.because guangdong area textile industry is developed, textile worker population is large. most front-line textile workers need to work in close proximity for a long time, and the problem of aging productivity is increasingly obvious. at present, no relevant studies have explored whether presbyopia affects the work efficiency of textile workers who work in close proximity. in this study, a randomized controlled clinical study will be conducted on front-line textile workers with presbyopia to explore whether refractive correction can improve labor income and relieve symptoms of visual fatigue for textile workers aged 40 years or above who work in the front-line.

Eligibility criteria:
inclusion criteria: * employee of e-square for 6 months; * aged \>= 40 years; * quantifiable near visual task workers; * habitual near visual acuity of \>= 0.8m (\ =6/7.5); * near correction spherical equivalent refractive error \>= +0.50d or astigmatism \<-1.00d; * asthenopia symptoms reported ( asthenopia questionnaire score \>= 16) ability to give informed consent exclusion criteria: * ocular surgery done in the past 3 months; * eye disease detected on baseline eye exam * current ownership of near correction capable of improving near visual acuity to \ = 6/12) in either eye * unlikely to complete follow-up due to unsatisfactory work performance, plans to move out of the area, etc.

Keywords: presbyopia textile worker
lidocaine for pessary check pain reduction

Conditions: Pelvic Organ Prolapse; Stress Urinary Incontinence

Summary: the primary objective of this study is to estimate the effect of lidocaine jelly on patient pain at the time of office pessary removal.

the purpose of the study is to investigate the effects of lidocaine jelly on patient pain at the time of office pessary removal and reinsertion. all patients presenting to the university of south florida urogynecology clinic for a pessary maintenance appointment or "pessary check" will be screened as potential study participants. after being informed of risks and benefits of participation, informed consent will be obtained. patients will be randomized into two groups: the control group or experimental group. the patient will complete a brief questionnaire and pain assessment using a visual analog scale (vas). patients will be blinded. the investigators will be unblinded. the investigators will apply the jelly (lidocaine vs lubricating). the participant will have an equal chance of being in the control arm or experimental arm. after 5 minutes, the investigator will assess the patient's genital hiatus with valsalva and proceed with pessary removal per the investigator's routine. the patient will complete another vas to indicate pain level after pessary removal. the investigator will perform a speculum exam per routine and then reinsert the pessary. the patient will complete a final vas to indicate level of pain after pessary reinsertion along with a brief final questionnaire.

Eligibility criteria:
inclusion criteria: * women aged 18 years or older * presenting for routine pessary management for prolapse, stress urinary incontinence, or both with a pessary in place * able to provide written informed consent * able to complete the visual analog scale exclusion criteria: * women less than 18 years of age. * patients who speak neither english nor spanish * pregnancy * medical contraindication to lidocaine * planned change in pessary size or type * patients who remove and reinsert their pessary at home

Keywords: pessary lidocaine pain reduction pessary check pessary removal pessary reinsertion lubricating jelly
screening for anal cancer in women with high-grade vulvar dysplasia or vulvar cancer.

Conditions: Vulvar Cancer; Cervical Cancer; Vulvar Dysplasia; Cervical Dysplasia; Anal Cancer; Anal Dysplasia; HPV-Related Anal Squamous Cell Carcinoma

Summary: almost half of all women will develop an hpv infection in their lifetime. while most infections are naturally asymptomatic or cleared by the immune system, some persist and can lead to the development of cervical, vulvar, or anal lesions and eventually cancer. screening regimens for these lesions are currently only in place for the cervix through regular pap tests. these pap tests usually involve an examination of the vulva -however, no screening procedures exist for anal cancer for women. several studies have suggested that women with existing gynecological lesions are more likely to develop anal lesions and anal cancer. here the investigators propose a multi-center study which seeks to screen for and treat anal cancer in women over the age of 40 with vulvar lesions and a stable immune system. the investigators will achieve this through performing anal pap smears on eligible women and conducting high resolution anoscopy (hra) and appropriate treatment procedures on those with abnormal anal cells. with enough evidence, there may be an indication to establish regular anal cancer screening measures in this potentially underserved population. hypothesis: the investigators hypothesize that at least 40% of women with vulvar cancer or vin2/3 will have abnormal anal cytology. 35% of the population will be hrhpv dna positive and 11% will additionally have ain2/3. this prospective study may lay the groundwork for routine anal screening regimens in ontario and help shift health policy to treat this population.


Eligibility criteria:
inclusion criteria: * women age ≥ 40 * previous diagnosis of vin 2/3 or vulvar exclusion criteria: * women with a previous diagnosis of cancer aside from basal cell carcinoma of the skin, cervical cancer, or vulvar cancer * women who are hiv positive * women currently taking immunosuppressant medication * women who have had a previous hysterectomy

Keywords: vulvar cancer cervical cancer vulvar dysplasia cervical dysplasia anal cancer anal dysplasia hpv
frequency domain optical imaging

Conditions: Breast Cancer

Summary: this purpose of this clinical study to develop and test technology associated with near infrared (nir) optical tomography of the breast (the use of light at nir wavelengths to image the breast) as an adjunct to mammography and breast mri.

the purpose of this clinical study is to demonstrate the feasibility of nir absorption and fluorescence imaging of the female breast when the method is guided by breast mri. the hypotheses to be tested are: 1. mr-guided nir absorption and fluorescence imaging of the breast is feasible in the setting of a clinical breast exam 2. mr-guided nir absorption and fluorescence imaging of the breast provides spatial localization and contrast of a breast abnormality that is superior to nir absorption and fluorescence tomography alone.

Eligibility criteria:
healthy volunteers inclusion criteria: 1. female, ≥20 years old 2. breast size and epithelial integrity adequate to allow nir imaging exams. 3. ability to provide written informed consent 4. no serious associated psychiatric illnesses. exclusion criteria: 1. absolute or relative contraindication to mri: 1. the presence of an electronic implant, such as a pacemaker 2. the presence of a metal implant, such as an aneurysm clip 3. claustrophobia 4. the presence of other contraindication(s), as determined by the mri technologists and radiologists. 2. pregnancy women with breast abnormalities inclusion: 1. female, ≥ 20 years old. 2. breast size and epithelial integrity adequate to allow nir imaging exams. 3. ability to provide written informed consent. 4. no serious associated psychiatric illnesses. 5. a recent screening mammogram that questions the presence of an abnormality, thus requiring further mammographic examination. exclusion: 1. absolute or relative contraindication to mri: 1. the presence of an electronic implant, such as a pacemaker 2. the presence of a metal implant, such as an aneurysm clip 3. claustrophobia 4. the presence of other contraindication(s), as determined by the mri technologists and radiologists. 2. pregnancy 3. a history of allergy to iodides 4. a gfr \< 30 ml/min as determined by blood test on the day of nir/mr imaging, or from lab results within 3 months of nir/mr imaging.
effect of minocycline on delirium incidence in critically ill patients

Conditions: Delirium; Coma

Summary: delirium is a disorder of consciousness characterized by an acute onset and fluctuating course of impaired cognitive functioning. it is associated with unfavorable outcomes in hospitalized patients, including longer hospital length of stay, need for subsequent institutionalization and higher mortality rates. patients in the intensive care unit (icu) under mechanical ventilation and older age are at higher risk for the development of delirium. several studies suggest that minocycline, through its anti-inflammatory effect, was able to prevent neuronal dysfunction in different models of icu-related diseases. thus, the present study aimed to evaluate the effect of minocycline on delirium development in critically ill patients. patients will be randomized into one of two groups: the intervention group that will receive 100mg of minocycline 2 times a day and the placebo group. medication or placebo will be continued for 28 days or until icu discharge (whichever occurs first). delirium will be diagnosed by the cam-icu. coma will be defined by the richmond agitation-sedation scale (rass) score of -4 or -5 and biomarkers will be used as alternative outcomes related to the pathophysiology of the disease (il-1, il-6, il-10, and bdnf).


Eligibility criteria:
inclusion criteria: * clinical or surgical patients, * over 18 years, * expected icu stay of at least 2 days estimated by the attending intensivist, * agree to participate in the study exclusion criteria: * delirium prior to inclusion, * diagnosis of parkinson's disease * diagnosis of dementia, * alcohol abuse history, * acute neurological condition at admission * history of psychiatric disease * use of antipsychotics * pregnant or breastfeeding women, * expectation of death within 2 days * hospitalized for exclusive palliative care * known allergy to minocycline

Keywords: delirium minocycline intensive care unit
defocus (dims) spectacles versus ortho-k lenses (okl) for slowing myopia progression in danish children aged 6-12 years.

Conditions: Myopia

Summary: the purpose is to compare the myopia control efficacy of ortho-k lenses (okl) and defocus (dims) spectacles in danish myopic children aged 6-12 years. it is a clinical randomized non-inferiority trial, where the participants are randomly assigned to either okl or dims spectacles. the participants are followed during 18 months of therapy. the hypotheses: * there is no statistically significant difference between the myopia control efficacy between okl and dims spectacles. * larger pupil size is positively correlated to treatment efficacy for both devises. * increasing choroidal thickness during early treatment is positively correlated to treatment efficacy for both devises. * there is no difference in vision related quality of life between the two groups.


Eligibility criteria:
inclusion criteria: * myopic children aged 6 to 12 years. myopia of the 6 to 8-year-olds: -1.00 to -4.75 d spherical component and up to -2.50 d of regular astigmatism. myopia of the 9 to 12-year-olds: -2.00 to -4.75 d spherical component and up to -2.50 d of regular astigmatism. * anisometropia \< 1,5 d cycloplegic spherical equivalent refractive error. * best corrected visual acuity: age 6 to 8 (inclusive) years: 0.8 snellen (equivalent to ≥ 3/5 letter on the 0.8 line = 78 etdrs letters). age 9 to 12 years: 1.0 snellen (equivalent to ≥ 3/5 letter on the 1.0 line = 83 etdrs letters) exclusion criteria: * manifest or latent squint. * contraindications to the use of okl comprising keratoconus, chronic allergic conjunctivitis and keratoconjunctivitis sicca. * previous eye surgery. * chronic eye disease demanding daily use of eye drops. * non-compliance to eye examinations