Kornimate/medical-research-clean huggingface dataset:
the therapeutic effect of different exercise intensities on weight loss in obese children

Conditions: Weight Loss; Obese Children and Adolescents

Summary: the incidence of childhood obesity is increasing, followed by metabolic diseases related to overweight and obesity in children. high intensity interval training (hiit) has recently been shown to improve the body composition and cardiovascular health of obese children. currently, there is little evidence on the impact of exercise intensity on endocrine and metabolic indicators and quality of life in obese children. the main purpose of this study is to compare the effects of short-term supervised high-intensity interval training and moderate intensity continuous training (mict) on metabolic indicators in obese children under an energy limited balanced diet. a multicenter prospective randomized controlled trial was conducted on 388 obese children in south china. the experimental group will be randomly assigned to (1) hiit and energy limited balanced diet, and (2) mict and energy limited balanced diet. the experimental group will participate in a 3-month (supervised) exercise training. the measurement of the study endpoint will be followed up at baseline, 3 months (after supervised intervention), 9 months, and 1 year. the primary endpoint is the percentage of weight loss (△ wt%). secondary endpoints include waist to height ratio, body mass index (bmi), body fat percentage, insulin resistance index (homa-ir), insulin secretion index (isi), and δ htsdsba. the results of this study will generate a wealth of information on the impact of exercise intensity on weight loss and endocrine metabolism in obese children, and develop more effective evidence-based exercise prescription guidelines in this population.


Eligibility criteria:
inclusion criteria: 1. the guardian understands and signs the informed consent. if the subject is at least 8 years old, the informed consent must be signed. 2. age 6\~16 years old, male and female; 3. bmi≥ \&#34;sex-age bmi reference point for obesity screening of school-age children aged 6-18 years\&#34;; 4. no disability; 5. joint cardiopulmonary function assessment showed that participation was safe; 6. at least one year of follow-up is expected. exclusion criteria: 1. have high blood pressure (defined as systolic or diastolic blood pressure values above the 95th percentile), any history or evidence of heart disease and/or abnormal resting or stress echocardiography or a combined cardiopulmonary function assessment indicating that participation is not safe; 2. have any chronic disease, such as chronic asthma, kidney disease, type 1 diabetes, epilepsy, etc.; 3. suffering from organic diseases, such as ovarian tumors, hamartoma, etc.; 4. a smoking habit or orthopedic/neurological condition that may limit exercise ability; 5. confirmed attention deficit hyperactivity disorder and steroid use.
ct mar technology and mr mavric, semac sequence in removing artifacts of orthopedic metal internal fixation

Conditions: Spinal Disease

Summary: 1. objective to compare the effect of single energy imaging and mar technology in reducing artifacts of knee and hip replacement, and to explore the appropriate kev range of mar technology in removing metal artifacts.,2. objective to compare the effects of different mri sequences (mavric / semac, stir, ideal, fse) in removing artifacts of spinal internal fixation, knee and hip replacement.

conventional spiral ct \[4\] examination will form black-and-white stripe artifacts around the metal implant, making the display of adjacent important structures unclear. in routine mri examination \[5\], metal will interfere with the uniformity of local magnetic field, resulting in signal loss, and the artifacts will seriously affect the observation of bone and its surrounding structures. the purpose of this study was to comprehensively evaluate the effect of mar technology on reducing metal artifacts after internal fixation and joint replacement, and then to explore the appropriate kev range of mar technology to reduce metal artifacts. we also aim to compare the reduction effect of different sequences of mri on internal fixation artifacts after internal fixation and joint replacement, and to explore the sequence suitable for clinical diagnosis and treatment.

Eligibility criteria:
inclusion criteria: * patients after spinal internal fixation or knee or hip replacement exclusion criteria: * patients with poor image quality caused by their own factors such as patients' movement can not meet the diagnostic requirements
development and implementation of an educational program to enhance adherence to glaucoma treatment

Conditions: Glaucoma

Summary: this study evaluates the addition of an educational intervention program in order to improve medication adherence in glaucoma patients. half of the participants will receive the educational program while the other half will receive normal care and a leaflet about glaucoma.

introduction. as the world population ages, glaucoma is becoming an increasingly significant cause of blindness. statistics gathered by who in 2010, show that glaucoma is the leading cause of irreversible blindness, worldwide. a key component in the management of glaucoma, is the use of prescribed medications· but the effectiveness of medications depends on patient's adherence to treatment. however, there is evidence of poor adherence to prescribed medication in chronic diseases and a causative factor for that is the limited education and the low health literacy. this study aims to investigate the reasons of non-adherence to the medication plan among patients with glaucoma and secondly, according the findings, to develop and implement a comprehensive educational program. methods and analysis. this is a mixed method study which include 3 stages: a descriptive study (stage 1), focus group discussion (stage 2) and a randomised control trial (stage 3). sample: patients with glaucoma, using at least one kind of drops, will be recruited from the two ophthalmology clinics in cyprus. selected measures include: glaucoma treatment compliance assessment tool (gtcat), european health literacy survey questionnaire (hls-eu-q6) and the glaucoma medication self-efficacy questionnaire (gmseq). the data will be analysed by spss program with descriptive and inferential statistics. content analysis will be used for the data from the focus groups. ethics and dissemination. permission to conduct the study received from the cyprus national bioethics committee (εεβκ επ 2019.01.220) and the board of management of the two ophthalmology clinics. all participants will be informed fully on the purpose and methods of the study. consent forms will be signed and at any time participants will have the right to withdraw. confidentiality of the participants will be respected as also the protection of data. dissemination strategy includes presentations in international and national scientific conferences and publications in scientific journals.

Eligibility criteria:
inclusion criteria: * patients older than 18 years of age * ability to read and understand greek * able to give informed consent * diagnosis of glaucoma or ocular hypertension, requiring treatment with hypotensive eye drops (at least one time per day). * patients who scored less than 80% adherent on gtcat exclusion criteria: * none

Keywords: medication adherence education* intervention
the effect of balance training in people with functional ankle instability (fai)

Conditions: Functional Ankle Instability

Summary: ankle sprain is the most occurring sport related injury. in addition, 40% of the people who sustain such an injury display residual symptoms under the general denominator functional ankle instability (fai). in literature, there is already given a lot of attention to extrinsic and intrinsic risk factors of fai. furthermore, there is a major focus on the possible interventions which may be able to reduce the chance of developing chronic instability. at this moment there is a lack of unequivocality. in this study the investigators address the question of what is the effect of a balance training programme on the movement strategy. therefore kinematics, kinetics, plantar pressure measurements and muscle activity are taken in consideration the purpose of this study is a better insight in the effect of treatment on the residual symptoms related to fai.


Eligibility criteria:
inclusion criteria: * a history of more than 1 unilateral ankle sprain * presence of feeling of 'giving way' * a feeling of weakness around the ankle * a decreased functional participation exclusion criteria: * ankle fracture * ankle surgery * lower limb pain (not related to an ankle sprain) * ankle distortion in the last 3 months * currently receiving treatment * disturbance of equilibrium

Keywords: functional ankle instability
efficacy and safety of a retinoid in the treatment of severe chronic hand eczema

Conditions: Eczema

Summary: the purpose of this study is to investigate the safety and efficacy of alitretinoin in the treatment of severe chronic hand eczema that does not respond to treatment with potent topical steroids.

chronic hand eczema (che)is a distressing disease that poses difficult problems for dermatologists. che leads to considerable work-absenteeism, disability and exclusion from labour market. conventional treatments, including highly potent topical steroids, yield often unsatisfactory results. this study investigates the efficacy and safety of oral alitretinoin, a retinoid, in patients who have not responded to avoidance of causative factors, such as contact allergens and skin irritants, non-medicated skin care and highly potent topical steroids. eligible patients are randomly assigned to receive alitretinoin or a placebo.

Eligibility criteria:
inclusion criteria: * all types of chronic hand eczema, lasting for at least 6 months since initial diagnosis * rated as severe by the physician * unresponsive to highly potent topical corticosteroids, such as clobetasol exclusion criteria: * patients whose disease is adequately controlled by standard non-medicated therapy, including potent topical steroids, skin moisturizers, and avoidance of allergens and irritants * patients with known allergens and irritants, who have not made a reasonable effort to avoid the substances * patients with psoriasis lesions * active fungal, bacterial or viral infections of the hands * female patients who are pregnant or breastfeeding * female patients of childbearing potential who cannot use or will not commit to use two effective methods of contraception

Keywords: retinoid treatment fingertip dermatitis hyperkeratotic hand eczema vesicular hand eczema pompholyx
progressive goal attainment program for veterans

Conditions: Mental Disorders; Worries; Pain or Disability

Summary: the purpose of this study is to test the effectiveness of the progressive goal attainment program (pgap) in improving employment outcomes and community engagement among u.s. veterans with disabilities.

veterans with disabilities often have low self-esteem and motivation, significant depression and a belief that their disability precludes them from gainful employment. the progressive goal attainment program (pgap) is specifically designed to target these psycho-social risk factors of disability. pgap is a structured, 10-week intervention that focuses on helping clients develop a planned activity schedule to assist them in resuming desirable life activities, including employment. the pgap for veterans project will test the feasibility of delivering pgap to u.s. military veterans. the research will focus on the best means of service delivery, staffing needs and how to coordinate pgap in a larger veteran service system. mdrc will also gather information on the target population, recruitment methods, the feasibility of scaling and replication, and employment outcomes among the sample. two hundred veterans will be enrolled and randomly assigned into the study across two sites: errera community care center within (part of the va connecticut health care system) and the michael debakey va medical center in houston, texas.

Eligibility criteria:
inclusion criteria: * self-reporting a disability. * unemployed or under-employed. * likely to benefit from pgap (i.e. unengaged in social and community activities, difficulty attaining work due to motivational factors). exclusion criteria: * does not consent to be in the study. * significant barriers: serious substance abuse, significant psychotic disorders and cognitive disabilities that would preclude them from active participation in pgap.

Keywords: perceived disability mental wellness employment social integration and engagement goal achievement
nutritional status in orthognathic surgery patients

Conditions: Malocclusion

Summary: the aim of this study is to determine the effect of orthognathic surgery on nutritional status, anthropometric measurements, food consumption levels, physical activity levels, biochemical parameters, chewing ability and oral-health impact profile.

sub-objectives of the study; * determining nutritional status changes after orthognathic surgery * determining changes in anthropometric measurements (body weight, bmi, fat mass, muscle mass, total body water, waist circumference, hip circumference, mid-upper arm circumference) after orthognathic surgery * determining food consumption changes after orthognathic surgery * determining changes is physical activity levels after orthognathic surgery * determining changes in biochemical parameters 3 months after orthognathic surgery * determining changes in chewing ability after orthognathic surgery * determining changes in oral-health impact profile after orthognathic surgery * determining changes in pain intensity the aim of this study is to compare these parameters preoperative to postoperative timeline of orthognathic surgery patients.

Eligibility criteria:
inclusion criteria: * 18-45 years old, * volunteer to participate in the study, * dysgnatic patients with malocclusion who applied to marmara university, faculty of dentistry, department of oral and maxillofacial surgery will be included in the study. * type of surgery (only patients with genioplasty operation will not be accepted) exclusion criteria: * patients with a history of acute facial trauma, * patients with previous facial surgeries, * pregnant or lactating women * those who have diseases that may cause systemic neuropathy such as diabetes, hypertension, kidney disease, * those who do not want to sign the consent form, * orthognathic surgery patients treated with genioplasty only, * patients with a history of eating disorders (anorexia nervosa, bulimia nervosa, etc.). * patients with a history of malignancy, radiotherapy or chemotherapy will be excluded from the study.

Keywords: orthognathic surgery malocclusion nutritional status
the asthma bronchial challenge study

Conditions: Asthma

Summary: this is a randomised, controlled, cross-over study to determine the effect of indirect bronchial challenge testing upon volatile organic compounds (vocs) in the exhaled breath of adults with well-controlled, mild-to-moderate asthma. participants will undergo baseline evaluation including clinical history, spirometry, exhaled nitric oxide measurement (feno), phlebotomy (blood eosinophil count), and sampling of exhaled breath vocs. participants will be randomised to receive either an indirect bronchial challenge test using mannitol dry powder (mdp) or a sham bronchial challenge, followed by further sampling of breath vocs. the study will consist of a consent visit and two assessment visits with participants allocated to receive one of the two challenges (mdp or sham) at each assessment. data will be analysed to determine the effect of bronchial challenge upon exhaled breath voc profiles.


Eligibility criteria:
inclusion criteria: * male or female * aged 18 or over * able to provide informed consent * self-report of asthma diagnosis from health professional * diagnostic confirmation meeting british thoracic society guidelines will be sought from primary care * non-smokers; or ex-smokers of at least two years duration with less than a ten pack year history * asthma control questionnaire score \< 1.0 * asthma treated according to level-1 to level-2 of british thoracic society treatment guidelines exclusion criteria: * respiratory tract infection, asthma exacerbation or change in treatment step within the previous four weeks * major chronic cardiorespiratory disease other than asthma * significant comorbid condition * condition that may be compromised by repeated spirometry manoeuvres or induced bronchospasm * asthma control questionnaire score \>1.0 * asthma treated at level 3 of the treatment guidelines or higher * pregnant or nursing mothers * current smokers or 'vapers' * ex-smokers of \ 10 pack years. * participating in a clinical trial of an investigational medicinal product (ctimp). * unable to speak english. * low baseline lung function (fev1 \<1.50 litres or \< 70% predicted value) * known hypersensitivity to mannitol, gelatin or strong anaphylactic response in the past.

Keywords: breathomics metabolomics exhaled breath test biomarker
addition of lactobacillus to metronidazole in treatment of cdad

Conditions: Enterocolitis; Pseudomembranous Colitis; Antibiotic-associated Colitis

Summary: the purpose of this study is to determine whether dietary supplementation with lactobacillus gg will reduce the rate of failure or relapse following treatment of cdad with metronidazole.

clostridium difficile associated disease (cdad), which nearly always follows antibiotic therapy, has become increasingly common and important in american hospitals, causing substantial morbidity and mortality. metronidazole is the recommended treatment for this condition. we have recently reported (clin infect dis, june 2005) that treatment with metronidazole is associated with a 22% rate of failure and 28% rate of relapse. no other medication has been shown to be more effective. there is a substantial theory and some limited data to suggest that dietary supplementation with non-pathogenic normal bowel bacteria will benefit these patients. lactobacillus gg is the best-standardized and the most extensively studied of these agents.

Eligibility criteria:
inclusion criteria: * subjects will be identified based on the diagnosis of cdad. this diagnosis is made bases on the presence of diarrhea, fever, abdominal pain and/or leukocytosis together with a positive fecal assay for clostridium difficile toxin exclusion criteria: * patients who are unable to take oral medications and those with underlying gastrointestinal disease or colonostomy will be excluded. * patients currently taking penicillins, cephalosporins, quinolones or tetracyclines will be excluded because these drugs are active against lactobacillus.

Keywords: cdad clostridium difficile associated diarrhea
90 days: an entertainment education intervention to evaluate a short film about hiv status disclosure

Conditions: HIV/AIDS

Summary: this investigation seeks to understand if and how, the 90 days film can be used as an intervention to address hiv-related stigmas, intimate partner status disclosure and hiv art medical adherence among black hiv positive women.


Eligibility criteria:
inclusion criteria: * black women ages 18-50 * clinically diagnosed with hiv/aids * speak and comprehend english exclusion criteria: * pregnant women
blq study: a study of a protease inhibitor with fuzeon (enfuvirtide) in treatment-experienced patients with hiv-1.

Conditions: HIV Infections

Summary: this single arm study will evaluate the efficacy, safety and tolerability of a new investigational protease inhibitor (pi) plus background antiretrovirals plus fuzeon (90mg sc bid) in hiv-1 infected, triple-class treatment-experienced, fuzeon-naive adults. the new investigational pi will be administered according to the procedures of the early access program in which the patient is enrolled. the anticipated time on study treatment is 3-12 months, and the target sample size is approximately 120 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, \>=18 years of age; * seropositive for hiv-1; * enrolled in an early access program for a new investigational pi; * naive to fuzeon, and the investigational pi; * treatment-experienced with 3 arv classes of drug (nrti, nnrti and pi). exclusion criteria: * females who are pregnant or breast-feeding; * evidence of active, untreated opportunistic infection; * malignancy requiring chemotherapy or radiotherapy.
parasitic infections and ulcerative colitis: combining anti-parasitic and immunomodulatory treatments may achieve remission

Conditions: Ulcerative Colitis

Summary: the study aimed to explore the link between parasitic infections and the severity of ulcerative colitis (uc). 120 uc patients were divided into three groups: those without infection, those with giardia lamblia infection treated with metronidazole, and those with giardia infection treated with a combination of metronidazole and e. purpurea. the results revealed that patients with giardia infections exhibited more severe uc symptoms. all groups experienced improved symptoms following treatment, but the combination therapy group demonstrated the most significant improvement. remission rates were highest in the group without infection and the group receiving combination therapy. additionally, the study identified e. purpurea therapy and a substantial reduction in sccai score as significant predictors of higher remission rates.


Eligibility criteria:
inclusion criteria: * ulcerative colitis patients had active disease, * patients had parasitic infection by g. lambellia, * patients free of parasitic infection, * patients free of exclusion criteria.. exclusion criteria: * patients had inflammatory bowel disease other than ulcerative colitis, * patients had multiple parasitic infections, * patients had infection by parasites other than g. lambellia, * patients who were maintained on immunosuppressant therapy, * patients who were in remission and patients refused to sign the written consent to participate in the study.