Kornimate/medical-research-clean huggingface dataset:
low dose euthyrox in treatments of paraquat intoxication.

Conditions: Paraquat Poisoning

Summary: paraquat is a common human toxicant and accounts for 20 deaths per million persons in the world. paraquat usually cause multiple organ dysfunction syndrome, including liver, kidney, lung and heart dysfunction. besides, pituitary insufficiency also occurs on those patients with paraquat poisoning, which leads to multiple endocrine gland dysfunction, involving adrenal gland, thyroid and sex gland. as a result, the investigators decide to initiate the clinical trial to find whether thyroid replacement therapy can furtherly reduce the mortality, and improve patients long-term prognosis.

paraquat is a common human toxicant and accounts for 20 deaths per million persons in the world. its accidental or deliberate ingestion is associated with a high mortality rate ranging from 40% to 70%. paraquat usually cause multiple organ dysfunction syndrome, including liver, kidney, lung and heart dysfunction. besides, pituitary insufficiency also occurs on those patients with paraquat poisoning, which leads to multiple endocrine gland dysfunction, involving adrenal gland, thyroid and sex gland. nowadays, steroids, as a hormone replacement therapy, is one of most important drugs for paraquat poisoning, and it has decreased patients' mortality greatly since using it. however, the clinicians have not paid enough attention to thyroid replacement therapy, as thyroid dysfunction is also the key pathophysiological course when paraquat poisoning occurs. as a result, the investigators decide to initiate the clinical trial to find whether thyroid replacement therapy can furtherly reduce the mortality, and improve patients long-term prognosis.

Eligibility criteria:
inclusion criteria: * all the patients who are diagnosed by paraquat poisoning exclusion criteria: * patients who can not cooperate with the trial; patients who would not like to join in the trial.

Keywords: euthyrox paraquat intoxication
the effect of cherry seed pillow on fibromyalgia

Conditions: Fibromyalgia

Summary: in this study, the effects of 4-week cherry seed pillow application on pain and quality of life in individuals diagnosed with fibromyalgia will be examined.


Eligibility criteria:
inclusion criteria: * over 18 years of age * diagnosis of fibromyalgia according to acr classification criteria * neuromuscular system examination is normal * pain (vas-visual anologous scale) level of at least 5 points * no communication problems * willingness to participate in the practice of using cherry seed cushion * to be capable of answering the data collection tools to be used in the research * not having made hot, cold etc. applications at home exclusion criteria: * -no diagnosis of fibromyalgia according to acr classification criteria * normal examination of the neuromuscular system * pain (vas-visual anologous scale) level between 0-5 * communication problems * failure to accept the practice of using cherry seed cushion and failure to finish the implementation process * having a musculoskeletal disorder other than fibromyalgia * pregnant or lactating * to be capable of answering the data collection tools to be used in the research * having made hot, cold etc. applications at home
attain performa(tm) quadripolar lead study

Conditions: Heart Failure

Summary: the purpose of the study is to evaluate the safety and efficacy of the medtronic attain performa quadripolar leads (model 4298, 4398, and 4598) during and post the implant procedure. this study will also assess the interactions of the attain performa leads with the entire medtronic crt-d system.


Eligibility criteria:
inclusion criteria: * patient is indicated for implant of a crt-d device and left-heart lead per local indications (in us only this is based on class i and ii indications for crt-d implant per hrs/acc/aha guidelines) * patient (or legally authorized representative) has signed and dated the study-specific consent form * patient is 18 years of age or older, or is of legal age to give informed consent per local and national law * patient is expected to remain available for follow-up visits * patient understands the study and agrees to comply with study protocol exclusion criteria: * patient has a previous lv lead implanted or previous implant attempt within 30 days of enrollment or has ongoing aes from a previous unsuccessful implant attempt * patient has contraindications for standard transvenous cardiac pacing (e.g., mechanical right heart valve) * patient has had a heart transplant (note: patients waiting for heart transplants are allowed in the study) * patient is contraindicated for \< 1 mg dexamethasone acetate * patient is currently enrolled or planning to participate in a potentially confounding drug or device study during the course of this study. (note: co-enrollment in concurrent studies may be allowed provided that documented pre-approval is obtained from medtronic's study manager) * patient has a life expectancy less than 180 days * patient with exclusion criteria required by local law (e.g. age, pregnancy, breast feeding, etc.) * in us, women of childbearing potential must have a negative pregnancy test 7 days prior to implant to be included * patient is unable to tolerate an urgent thoracotomy

Keywords: heart failure cardiac pacing cardiac resynchronization therapy left ventricular lead
quadratus lumborum block in pediatric patients

Conditions: Postoperative Pain

Summary: quadratus lumborum block (qlb) is a newly-defined trunk block performed with local anesthetic injection by imaging the abdominal muscles with ultrasonography (us) guidance; thus, analgesia is expected to be ensured from the t7-l1 dermatomal segment level. in the study, the aim was to compare the postoperative analgesic effect of quadratus lumborum block in pediatric patients undergoing lower abdominal surgery

patients included in the study were randomly divided into 2 groups. cases were assessed as intravenous opioid with 1 mg/kg tramadol hcl (group o, n=20) or ultrasonography-guided quadratus lumborum block (group b, n=20). total analgesic amounts in 24 hours and first analgesic requirement times recorded.

Eligibility criteria:
inclusion criteria: * the study included 40 cases undergoing lower abdominal surgery aged from 3 to 16 years with asa (american society of anesthesiologist) i-ii level. exclusion criteria: * cases with asa iii-iv health level and those with a history of allergy to local anesthetic medications were not included in the study.

Keywords: quadratus lumborum block, abdominal trunk block
head elevation during pre-oxygenation can delay desaturation time

Conditions: Surgery; Desaturation of Blood; Apnea

Summary: this study is a randomized-controlled trial study comparing the association between several degree of head elevation and conventional position during pre-oxygenation to desaturation time in patients undergo endotracheal intubation with general anesthesia

preoxygenation anesthesia induction is an important part of airway management to reduce the risk of hypoxemia when the patient is apneic. the effectivity of preoxygenation is influenced by several things such as patient's head position. this study aimed to compare preoxygenation with head elevation 20°, 30° and 45° and conventional position to the time of desaturation before endotracheal intubation in patients undergoing general anesthesia. this was a randomized clinical trial of 56 patients, divided into four groups (conventional or 0° head elevation group, 20° head elevation group, 30° head elevation and 45° head elevation group). all subject was preoxygenated for 3 minutes with 100% oxygen. induction of anesthesia was started with fentanyl, propofol, followed by rocuronium after the patient lost consciousness. time was recorded from the start of induction until the oxygen saturation showed 93% or a time limit of 5 minutes. there was a significant difference in mean desaturation time among the four groups (p = 0.011). the most significant different was in 45o head elevation group (p \< 0.05). . in patients undergoing general anesthesia, pre-oxygenation with head elevation 20°, 30° and 45° slows down the time for desaturation before endotracheal intubation compared to the conventional position. the 45° head elevation has the best result.

Eligibility criteria:
inclusion criteria: * undergo endotracheal intubation with general anesthesia for elective surgery * aged 18-60 years old * asa physical status 1-2 preoperatively exclusion criteria: * patients with difficult airway, cardiopulmonary disease, anemia, grade ii obesity, pregnant, history of hypersensitivity to induction agents * patients did not give consent to follow the study

Keywords: preoxygenation head elevation desaturation apnea
a study of belzutifan (mk-6482) in participants with renal impairment (mk-6482-021)

Conditions: End Stage Renal Disease; Renal Impairment

Summary: the primary purpose of this study is to compare the plasma pharmacokinetics (pk) of belzutifan (mk-6482) following a single oral 120 mg dose in participants with end stage renal disease (esrd) before and after hemodialysis (hd) to each other and also to that of healthy matched control participants. this study will also evaluate the safety and tolerability of a single oral 120 mg dose of belzutifan in participants with esrd and the extent of belzutifan removed by hd.


Eligibility criteria:
inclusion criteria: for participants with healthy renal function * is in good health based on the opinion of the investigator. * male participants agree to remain abstinent from heterosexual intercourse on a long-term basis or must agree to use contraception as instructed. * female participants must be of nonchildbearing potential. for participants with end stage renal disease (esrd) * with exception of the renal impairment, is in good health based on the opinion of the investigator. * has esrd maintained on stable regimen of at least 3 times per week hemodialysis (hd) for at least 3 months prior to the initial administration of the study intervention. * male participants agree to remain abstinent from heterosexual intercourse on a long-term basis or must agree to use contraception as instructed. * female participants must be of nonchildbearing potential. exclusion criteria: for participants with healthy renal function * has a history of clinically significant endocrine, gastrointestinal (gi), cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases. * has a history of cancer (malignancy). * is positive for hepatitis b surface antigen (hbsag), hepatitis c antibodies or human immunodeficiency virus (hiv). * had major surgery, donated or lost 1 unit of blood (approximately 500 ml) within 4 weeks prior to the prestudy (screening) visit. * has received any non-live vaccine starting from 14 days prior to study intervention or is scheduled to receive any non-live vaccine through 30 days following study intervention (except coronavirus disease 2019 \[covid-19\]). participants with esrd * has a history of cancer (malignancy). * has required frequent emergent hd (≥3) within a year prior to the initial dose of study intervention. * is positive for hbsag, hepatitis c antibodies, or hiv. * had major surgery, donated or lost 1 unit of blood (approximately 500 ml) within 4 weeks prior to the prestudy (screening) visit. * has received any non-live vaccine starting from 14 days prior to study intervention or is scheduled to receive any non-live vaccine through 30 days following study intervention (except covid-19)
allergen provocations- hca children's hospital

Conditions: Allergy in Children

Summary: a prospective study of all allergen provocations performed in children at the hans christian andersen children's hospital.

the purpose of the study is to investigate the impact of co-morbidities, history, and allergen tests on the outcome of allergen provocation tests. subjects are children aged 0-18 years old investigated for allergy to foods or antibiotics. data entered in the database are demographics, co-morbidities, symptoms, spt, specific ige and details of the allergen provocations.

Eligibility criteria:
inclusion criteria: clinical suspicion of allergy to foods or antibiotics informed concent - exclusion criteria: -
pharmacokinetics of lenalidomide (revlimid®) in patients with multiple myeloma and impaired renal function

Conditions: Multiple Myeloma; Impaired Renal Function

Summary: the purpose of this study is to determine the pharmacokinetic profile of revlimid® in patients presenting with multiple myeloma and impaired renal function, the safety of revlimid® in the enrolled patients population. and evaluate the efficacy of revlimid®-dexamethasone combination in patients presenting mm and impaired renal function at completion of 3 cycles of treatment.


Eligibility criteria:
inclusion criteria: * documented diagnosis of relapsed or refractory multiple myeloma (mm). * age \> 18 years at the time of signing the informed consent form * stable renal function exclusion criteria: * documented amyloidosis * any prior use of revlimid ® * any contraindication to revlimid ® and especially: * lack of acceptable method of birth control for female of childbearing potential (fcpb) * men who don't agree to use condom during the study and 4 weeks after the last study drug intake if their partner is a fcpb. * pregnant or breast feeding women

Keywords: multiple myeloma impaired renal function
application of motor unit estimation index in amyotrophic lateral sclerosis and related diseases

Conditions: Amyotrophic Lateral Sclerosis

Summary: this was a cross-sectional study in which patients were divided into 20 patients with amyotrophic lateral sclerosis, 20 patients with peroneal muscular dystrophy, 20 patients with kennedy's disease and 30 healthy controls, in which patients with amyotrophic lateral sclerosis continued to be followed up for 1 year and the results of 4 cross-sectional examinations were taken.

background amyotrophic lateral sclerosis (als) is a neurodegenerative disease that usually starts in middle age and manifests mainly as progressive atrophy and weakness of skeletal muscles throughout the body, with death from respiratory muscle involvement after 3 to 5 years. there are no biomarkers for early diagnosis and no effective treatments. because of the rapid progression of amyotrophic lateral sclerosis, it is important to find indicators that can objectively reflect early changes in the disease. the motor unit number index (munix) is a non-invasive, rapid and objective method to assess the number of motor units, which reflects the loss of motor neurons and has its theoretical basis in monitoring early disease progression. objective to explore the diagnostic value of munix in motor neuron disease and other related disorders. to investigate the role of the 1-year rate of change of munix in monitoring the disease progression in patients with amyotrophic lateral sclerosis. to investigate the role of munix in predicting survival analysis of als patients \[design\] this was a cross-sectional study in which patients were divided into 20 patients with amyotrophic lateral sclerosis, 20 patients with peroneal muscular dystrophy, 20 patients with kennedy's disease and 30 healthy controls, in which patients with amyotrophic lateral sclerosis continued to be followed up for 1 year and the results of 4 cross-sectional examinations were taken.

Eligibility criteria:
inclusion criteria: * als patient group: 20 patients with confirmed or proposed als meeting the 1998 revised el escorial diagnostic criteria for limb onset als. * cmt group: 20 patients with peroneal muscular dystrophy meeting the genetically confirmed diagnosis, who signed an informed consent form. * kd group: 20 patients with genetically confirmed kennedy's disease consistent with genetic diagnosis, signed informed consent. * healthy controls: 1. age-matched healthy adults who volunteered to participate; 2. definite exclusion of tremor, tonicity, and prior brain disease; 3. exclusion of common disorders affecting peripheral nerves such as entrapment peripheral neuropathy, diabetic peripheral neuropathy, and alcoholic peripheral neuropathy; 4. signed informed consent. exclusion criteria: 1. signs of sensory impairment; 2. significant sphincter dysfunction; 3. visual and oculomotor impairment; 4. autonomic dysfunction; 5. signs of extravertebral symptoms; 6. severe cortical dysfunction; 7. als-like syndrome.
on demand treatment of reflux disease

Conditions: Gastroesophageal Reflux

Summary: a comparison of the effect of on demand treatment with a pectin-containing natural product (aflurax) with that esomeprazole (nexium)

a randomized, controlled, open trial comparing the symptomatic effect of a pectin-containing product (aflurax) with that of esomeprazole (nexium 20 mg) given on-demand for 6 weeks.

Eligibility criteria:
inclusion criteria: mild and moderate reflux symptoms age \> 17 years informed consent - exclusion criteria: other conditions that might explain the symptoms abuse of drugs or alcohol -

Keywords: gastroesophageal reflux esomeprazole drug treatment
proof-of-concept interventional study with a nasal spray of jt-1 in patients with chronic rhinitis or chronic sinusitis

Conditions: Chronic Rhinitis; Chronic Sinus Congestion

Summary: proof-of-concept study with a novel nasal spray in chronic rhinitis or chronic sinusitis. the study will involve 25 patients completing the study for a per protocol analysis.

visit 1 (day 0): screening visit. assessment of outcome measures visit 2 (day 7): enrollment visit after a 1-week wash-out period. enrolled to the study are only patients who show a severe enough and stable disease (snot score \>20 and change of snot score \<15% compared to visit 1, respectively). visit 3 (day 21): assessment of outcome measures after 2-week treatment phase visit 4 (day 49): follow-up visit

Eligibility criteria:
inclusion criteria: * clinically diagnosed chronic allergic rhinitis or chronic sinusitis with no or a mild status of nasal polyp activity * disease lasting 12 weeks or longer * patients with moderate or severe symptoms (snot-22 score \>20) * male or female at least 18 years old * females in childbearing age are requested to make a pregnancy test and to confirm in writing to take contraceptive measures until follow-up visit (day 49). * patient understands german exclusion criteria: * severely purulent forms of sinusitis * history of medication during the last four weeks * not allowed: antibiotics, systemic or topical steroids * allowed: nasal saline spray or irrigation, analgesics, decongestants, antihistamines * patient has a status of moderate or severe polyp activity in the nose * patient had sinus surgery in the past 6 months * patient needs o2 substitution * patient has cystic fibrosis * patient has primary ciliary dyskinesia * patient is demented or otherwise incapable of judgement

Keywords: rhinitis, sinusitis, rhinosinusitis
efficacy of acetaminophen alone versus combination of acetaminophen/ibuprofen after cesarean section

Conditions: Cesarean Section; Postoperative Pain

Summary: the investigators aim to compare the analgesic efficacy of intravenous acetaminophen alone versus combination of acetaminophen/ibuprofen (maxigesic®iv) in multimodal analgesia after cesarean section.


Eligibility criteria:
inclusion criteria: * patients scheduled for elective cesarean section * gestational age \> 37+0 weeks exclusion criteria: * emergency cesarean section * multiple pregnancy (e.g. twins, triplets) * body weight \< 50 kg * preeclampsia * history of hypersensitivity to acetaminophen or ibuprofen * history of upper gastrointestinal tract bleeding or gastric ulcer * underlying liver disease * underlying kidney disease or gfr \< 90 ml/min/1.73m2 * heart failure or severe hypertension * history of asthma * chronic use of barbital or tricyclic antidepressants
will cleaning the bowel with an enema before vaginal prolapse surgery prevent complications?

Conditions: Colon Cleansing

Summary: traditionally, many gynecologic surgeons have asked patients to perform a cleansing enema the night before a vaginal surgery done to repair pelvic organ prolapse (dropped bladder, dropped uterus). the belief is that there is then less or no stool present at the vaginal incision and less chance of infection of the wound by bowel bacteria. however, not all surgeons follow this practice. there is no evidence in the medical literature if one way is better than the other. in this study, patients scheduled for vaginal surgery to correct prolapse will be randomly assigned to perform an enema or not to perform an enema.

the factors to be measured will be wound infection rates, and need to cleanse an incision of escaped stool.

Eligibility criteria:
inclusion criteria: * female, and * undergoing vaginal surgery for prolapse. exclusion criteria: * pregnant women, * age younger than eighteen, * male sex, or * concurrent abdominal surgery.

Keywords: the focus of this study is to determine whether it is beneficial to administer enemas before surgery
innervation of human cricopharyngeal muscle by recurrent laryngeal and external branch of superior laryngeal nerve

Conditions: Larynx

Summary: the investigators hypothesized that, external branch of the superior laryngeal nerve (ebsln) and/or recurrent laryngeal nerve (rln) contribute to the motor function of the human cricopharyngeal muscle (cp). the investigators aimed to assess the contribution of the laryngeal nerves (ebsln and rln) to the motor activity of the cricopharyngeal muscle, during thyroidectomy with intraoperative neuromonitoring (ionm).

this study group consisted of a consecutive patients undergoing thyroid surgery with intraoperative neuromonitoring (nim 3.0 nerve monitoring systeme (medtronic xomed, jacksonville, fl, usa) ) for various diseases. in all patients, each side of the neck operated was considered as a separate entity in our study. emg recordings were accomplished with a pair of needle electrodes inserted into the cp and mid-portion of the ct muscle that is located on the superior side of the rln, which were plugged into the third and fourth channels of interface-connector box, respectively, at the end of the thyroidectomy or lobectomy. the investigators evaluated the innervation pattern of the ct muscle in an other study. therefore the ebsln is the main supplier of the ct muscle, the emg findings of the ct muscle were used to confirm it, in this study. ebsln, pharyngeal plexus (pp), rln and vagus nerve were stimulated with a monopolar stimulator probe at 1 ma. while stimulating these nerves, the ipsilateral cp muscle was visually observed for possible contractions and electromyographic recordings were obtained with the 4-channel nim 3.0 nerve monitoring system.

Eligibility criteria:
inclusion criteria: * the patients who underwent thyroidectomy. exclusion criteria: * preoperative rln palsy * thyroid cancer with massive extrathyroidal extension * intentional nerve transection because of cancer invasion * the assessment failure of nerve function due to the technical deficiency of the ionm equipment

Keywords: cricopharyngeal muscle innervation by ebsln a prospective case-controlled study