Kornimate/medical-research-clean huggingface dataset:
a trial of evl\gvs alone vs. evl\gvs combined propranolol (s-hcc)

Conditions: Gastroesophageal Varices Hemorrhage; Hepatocellular Carcinoma

Summary: patients with hepatocellular carcinoma and esophageal varices bleeding were randomized to undergo endoscopic ligation alone (group a) and additive propranolol treatment (group b) after stabilization of their first acute bleeding.

esophageal variceal bleeding is characteristic of high rebleeding rate and mortality. thanks to the recent advance of treatment for variceal bleeding such as non-selective beta blocker (nsbb) added to endoscopic ligation further reduce rebleeding in cirrhotic patients, the rebleeding rate and mortality has a marked reduction. however, hepatocellular carcinoma (hcc) is a distinct group characteristic of very poor prognosis in patients with portal hypertension when compared to those of liver cirrhosis only. therefore, the investigators design a study to randomize patients with hcc and acute variceal bleeding to endoscopic treatment alone and combination with endoscopic treatment and nsbb. this is the two years study.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of hcc 2. endoscopically proven acute variceal bleeding 3. younger than 18 years old or older than 80 years old exclusion criteria: -had a terminal illness of any major organ system,such as heart failure, kidney failure,copd

Keywords: variceal bleeding portal hypertension hepatocellular carcinoma endoscopic variceal ligation non-selective beta-blocker rebleeding
emotional freedom liberation technique, surgical fear and anxiety

Conditions: Emotional Distress

Summary: aim: in this study, the effect of emotional freedom technique applied to patients before laparoscopic cholecystectomy on surgical fear and anxiety was investigated. design: this is a randomized controlled study. method: a total of 112 patients who were going to have laparoscopic cholecystectomy were randomly divided into two groups each including 56 participants. the intervention group was provided with emotional freedom technique. the control group received routine face-to-face education. surgical fear and anxiety were examined.


Eligibility criteria:
inclusion criteria: * clinical treatment for laparoscopic cholecystectomy * 18 years of age or older * mentally healthy exclusion criteria: * agree to participate in the study

Keywords: surgery anxiety
effects of and exploring the processes of free movement dance as a physical therapy intervention for female patients diagnosed with chronic widespread pain (including fibromyalgia).

Conditions: Fibromyalgia; Chronic Widespread Pain

Summary: the study has three parts: part 1: to evaluate, for adult female patients diagnosed with chronic widespread pain (including fibromyalgia), the effects of free movement dance as an add-on intervention after interdisciplinary pain management/rehabilitation at a specialist pain clinic versus modified person-centered progressive resistance exercise. the cognitive-behavioural conceptualization of pain, effects on pain intensity, physical function, self-efficacy, pain catastrophizing, health related quality of life, anxiety and depression symptoms and quality of sleep will be evaluated. part 2: to explore, for adult female patients diagnosed with chronic widespread pain (including fibromyalgia), the processes of free movement dance, as an add-on intervention after interdisciplinary pain management/rehabilitation at a specialist pain clinic, to generate a substantive theory useful for clinical praxis. part 3: to explore and describe why participants who agreed and signed consent choose to withdraw from participating in the interventions of the study's part 1.


Eligibility criteria:
inclusion criteria: * female patients diagnosed with chronic widespread pain (including fibromyalgia) participating in an interdisciplinary pain management and rehabilitation for three months on a specialist pain clinic in south-west of sweden. * age over 18 years and to be able to read and write swedish. - exclusion criteria: * red flag disorders such as malignancy/cancer, acute traumas such as fracture (less than six months ago) or infection. * pregnancy, severe mental illness, and ongoing substance abuse. * yellow flags as issues with compensation system or unsolved insurance issues with insurance company or the swedish social insurance agency. -
oct imaging of papilledema in pediatric idiopathic intracranial hypertension

Conditions: Pediatric Idiopathic Intracranial Hypertension

Summary: longitudinal clinical observation of optic nerve head, using slit lamp fundoscopy, guides therapy in pediatric idiopathic intracranial hypertension (iih) patients; however, it remains a limited method of producing quantitative data in evaluating in patients with iih. in this study we intend to compare, by using spectral domain optical coherence tomography (oct), the mean retinal nerve fiber layer thickness and total retinal thickness (rnflt/trt) of the optic nerve of newly diagnosed iih children to a control group. this will provide a quantitative measure for follow-up and treatment of this patient group.


Eligibility criteria:
inclusion criteria: * children with suspected iih exclusion criteria: * retinal disease * high refractive error * unable to undergo oct imaging
safety and immunogenicity of the 'eupcv15' in healthy korean adults

Conditions: Pneumococcal Disease

Summary: the safety and immunogenicity of eupcv15 compared to prevenar13 are assessed in healthy adults.


Eligibility criteria:
inclusion criteria: 1. healthy adults aged 19 to 50 years old 2. participants willing to give written informed consent to participate in the trial exclusion criteria: 1. history of invasive pneumococcal infection within 5 years at screening 2. known hypersensitivity to any component of the study vaccine 3. immune deficiency or immunosuppressive disorder 4. immunized with any licensed vaccine within 4 weeks prior to screening 5. pregnant, lactating women or women of childbearing age not using a reliable method of contraception 6. participants who in the opinion of the investigator will not be able to comply with any of the protocol required procedure
european study on three different approaches to managing class 2 cavities in primary teeth

Conditions: Dental Caries

Summary: the purpose of this randomized clinical trial is to compare the clinical effectiveness of three treatments involving different caries management strategies (conventional restorations, hall technique, and non-restorative caries treatment) to the management of class ii carious primary molars in children (3-8 year-old).

at present, many materials and techniques are used to treat carious primary teeth. all of these have their proponents who claim they provide the best performance in terms of longevity, aesthetics, bio-compatibility, etc (qvist, 2010; yengopal et al., 2009). however, despite the great variety of techniques and materials, there is no definite evidence for the most effective approach when dental caries in primary molars is concerned, as yet. on the other hand, there is conclusive evidence that shows that glass-ionomer cement is an inappropriate material for class ii restorations in primary teeth, due to its significant shorter longevity compared with other restorative materials like compomer and amalgam. recently, there is re-surging interest in more biological (less-invasive) techniques: such as the non-restorative caries treatment (peretz \& gluck, 2006; gruythuysen et al., 2010) or stainless steel crowns with the advent of the hall technique in scotland (innes et al., 2007). however, there is lack of comparative evidence from high quality clinical trials leading to uncertainty in the effectiveness of these techniques. in addition, these techniques are rarely compared with standard fillings.

Eligibility criteria:
inclusion criteria: - children aged 3-8 years who attend the preventive and paediatric department of greifswald university, germany. (lithuania: children who attend the paediatric dentistry department, dental faculty, lithuanian university of health sciences) * at least one primary molar tooth with caries into dentine involving two dental surfaces (diagnosed according to the international caries detection and assessment system \[icdas\], codes 3 to 5) * willing to be examined exclusion criteria: * clinical or radiographic signs of pulpal or peri-radicular pathology * patients with a systemic disease requiring special considerations during their dental treatment. * parents/children who refuse to participate in the study

Keywords: class ii carious primary molar non-restorative caries treatment hall technique conventional restorations children
a study of mt-101 in subjects with cd5+ relapsed/refractory tcl

Conditions: Lymphoma, T-Cell, Peripheral; Lymphoma, T-Cell, Cutaneous; Mycosis Fungoides; Adoptive Cellular Immunotherapy; Cell Therapy

Summary: this is a phase 1/2 study to test the safety, tolerability, and efficacy of the investigational agent mt-101 in patients with t cell lymphoma. mt-101 is made with myeloid cells collected from the patient's blood. the myeloid cells are modified and later infused back into their veins. the modified myeloid cells recognize the tumor cells and are designed to target and kill them.

the research study is divided into two parts. the first part will be to determine the safety and tolerability of the study drug product. during this part of the study, there will be 4 groups of study patients. the first group of patients will receive a low dose of cells, the second group will receive the low dose of cells and lymphodepleting chemotherapy to reduce the number of t cells in the blood, the third group will receive a higher dose of cells, and the fourth group will receive the higher dose of cells and lymphodepleting chemotherapy to reduce the number of t cells in the blood. in the second part of the study, cells with or without chemotherapy will be administered based on results of part 1 and the safety, tolerability, and efficacy of mt-101 will be assessed. all patient groups will receive 6 doses of drug product over 3 weeks.

Eligibility criteria:
key inclusion criteria: * adults age \> or equal to18 at the time the informed consent is signed * refractory or relapsed pathologically confirmed t cell lymphoma (tcl): peripheral t cell lymphoma not otherwise specified (ptcl-nos) , angioimmunoblastic t cell lymphoma (aitl), alk-negative anaplastic large cell lymphoma (alcl), alk-positive alcl, or mycosis fungoides (mf) stage iib-iv including large cell transformation * cd5-expressing tumor by ihc or flow cytometry of tumor biopsy within 3 months of screening or at screening * eastern cooperative oncology group performance status \< 2 * adequate organ function as defined in the protocol. key exclusion criteria: * b1 and b2 disease (as defined in protocol for subjects with mf) * known central nervous system involvement by ptcl * history of allogeneic transplant * history of intolerance to leukapheresis, plasmapheresis, or blood donation * pregnant or nursing women * any acute illness including fever (\> 100.4°f or \> 38°c), except fever related to tumor * active systemic bacterial, fungal, or viral infection * active chronic infection * other primary malignancies, except adequately treated malignancies or complete remission * active autoimmune disease that has required systemic therapy in the last 2 years * history of hemophagocytic lymphohistiocytosis * history of severe, immediate hypersensitivity reaction attributed to penicillin * any other condition that, in the opinion of the investigator, would make the subject unsuitable for the study or unable to comply with the study requirements.

Keywords: t cell lymphoma ptcl ctcl mf mt-101 cd5 chimeric antigen receptor myeloid cells monocytes chimeric antigen receptor car monocyte therapy
influence on the effect of an oral contraceptive drug after administration of liraglutide in postmenopausal women

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in europe. the aim of this trial is to investigate if liraglutide changes auc (area under the curve) of ethinylestradiol and levonorgestrel administered as a combination contraceptive drug (neovletta®).


Eligibility criteria:
inclusion criteria: * postmenopausal woman * body mass index (bmi) between 18.0-30.0 kg/m\^2 (both inclusive) * good general health as judged by the investigator, based on medical history, physical examination including 12-lead ecg (electrocardiogram), vital signs, blood and urinary laboratory assessments exclusion criteria: * history of any clinically significant renal, hepatic, cardiovascular, pulmonary, gastrointestinal, metabolic, endocrine, haematological, neurological, psychiatric disease or other major disorders that may interfere with the objectives of the trial, as judged by the investigator * impaired renal function * active hepatitis b and/or active hepatitis c * positive hiv (human immunodeficiency virus) antibodies * known or suspected allergy to trial products or related products * pregnant or positive pregnancy test at screening or nursing mother * use of prescription or non-prescription medication within 2 weeks prior to first dosing with trial products which in the investigators opinion will interfere with the pharmacokinetics of the compounds in neovletta® * use of hormone replacement therapy within 4 weeks prior to starting dosing with trial product * history of alcoholism or drug abuse * smoking of more than 10 cigarettes per day, or the equivalent for other tobacco products * habitual excessive consumption of methylxanthine-containing beverages and foods (coffee, tea, soft drinks such as cola, chocolate) as judged by the investigator * excessive consumption of a diet deviating from a normal diet as judged by the investigator
clinical outcomes of robotic versus laparoscopic assisted radical gastrectomy for advanced siewert ii/iii aeg

Conditions: Esophagogastric Junction Adenocarcinoma

Summary: the purpose of this study is to explore the clinical outcomes of the robotic assisted radical gastrectomy for advanced siewert ii/iii esophagogastric junction adenocarcinoma（ct2-4a, n-/+, m0）

in recent years, the incidence of gastric cancer has been decreasing year by year in the world, but the incidence of adenocarcinoma of the esophagogastric junction (aeg) has shown a significant upward trend, especially in western countries such as europe and the united states. the prognosis of aeg is poor, therefore, it is extremely necessary to establish aeg's best diagnosis and treatment strategies to improve the long-term outcome of aeg. robotic surgery has been developed with the aim of improving surgical quality and overcoming the limitations of conventional laparoscopy in the performance of complex mini-invasive procedures. the study is designed to explore the clinical outcomes of the robotic assisted radical gastrectomy for advanced siewert ii/iii esophagogastric junction adenocarcinoma (ct2-4a, n-/+, m0) by comparing with laparoscopic assisted.

Eligibility criteria:
inclusion criteria: * age from over 18 to under 75 years * primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or poorly differentiated) confirmed pathologically by endoscopic biopsy * ct2-4a(clinical stage tumor), n-/+, m0 at preoperative evaluation according to the american joint committee on cancer (ajcc) cancer staging manual 8th edition * expected to perform total gastrectomy with d2+no.19+no.20 lymph node dissction to obtain r0 resection sugicall results. * performance status of 0 or 1 on ecog (eastern cooperative oncology group) scale * asa (american society of anesthesiology) class i to iii * written informed consent exclusion criteria: * women during pregnancy or breast-feeding * severe mental disorder * history of previous upper abdominal surgery (except laparoscopic cholecystectomy) * history of previous gastric surgery (except esd/emr (endoscopic submucosal dissection/endoscopic mucosal resection )for gastric cancer) * gastric multiple primary carcinoma * enlarged or bulky regional lymph node （diameter over 3cm）supported by preoperative imaging * history of other malignant disease within the past 5 years * history of previous neoadjuvant chemotherapy or radiotherapy * history of unstable angina or myocardial infarction within the past 6 months * history of cerebrovascular accident within the past 6 months * history of continuous systematic administration of corticosteroids within 1 month * requirement of simultaneous surgery for other disease * emergency surgery due to complication (bleeding, obstruction or perforation) caused by gastric cancer * fev1\<50% of the predicted values
fractional co2 laser combined with prp fluid versus gel in treatment of acne scars

Conditions: Atrophic Acne Scar

Summary: this study is to test the efficacy of fractional laser combined with either prp fluid or prp gel in the treatment of atrophic acne scars

the study will include 20 patients, treated with fractional co2 laser plus prp fluid on one side of the face and fractional co2 laser plus prp gel on the other side. choosing which side of the face will be injected with prp fluid and which side will be injected with prp gel will be chosen according to a randomization table for each patient.

Eligibility criteria:
inclusion criteria: * age above 18 * both genders * skin types iii - v * willingness and ability to comply with the requirements of the protocol * atrophic acne scars exclusion criteria: * patients with active acne * patients with herpes labialis, bacterial infections, other infections such as hbv. hcv or hiv. * oral isotretinoin use in the previous 6 months * pregnancy * tendency to keloid formation * patients with severe systemic illness or malignancy * patients with connective tissue diseases * patients with bleeding tendencies or any other hematological disease
a phase ii study of 250-mg zd1839 monotherapy in recurrent or metastatic or both recurrent and metastatic squamous cell carcinoma

Conditions: Head and Neck Cancer

Summary: the purpose of this study is to find out what effects (good and bad) zd1839 has on one's squamous cell head and neck cancer. the research is being done because currently no effective treatment exists for metastatic (spread of cancer cells from one area of the body to another) or recurrent squamous cell cancer of the head and neck. the purpose of this study is to find out if zd1839 can shrink tumors or cause tumors to stop growing for a period of time.


Eligibility criteria:
inclusion criteria: * histologically confirmed squamous cell carcinoma of the head and neck incurable by surgery or radiation * patients must have measurable disease, defined as at least on e lesion that can be accurately measured in the one dimension (longer diameter to be recorded) as greater then or equal to 20mm with conventional techniques or as greater than or equal to 10mm with computed tomograpy (ct) scan. therapeutic history that includes the following: * no prior egfr-based therapy for recurrent disease * no chemotherapy or irradiation with the 28-day period preceding entry to the study * eastern cooperative oncology group (ecog)performance status 0-2 (kamofsky \>59%) patients must have normal organ and marrow function as defined below: * leukocytes \>3,000ml * absolute neutrophil count 1,500/ml * platelets 100,000/ml * total bilirubin within normal institutional limits * ast(sgot)alt(sgpt) \<2.5 x institutional upper limits of normal * creatinine \<1.5 exclusion criteria: * other coexisting malignancies or malignancies diagnosed within the last 5 years with the exception of basal cell carcinoma or cervical in situ. * concomitant use of phenytoin, carbamazepine, barbiturates, rifampicin, phenobarbital, ketoconazole, erythromycin, clarithromycin, atorvastatin, cimetidine, ametidine, amitriptyline, imipramine, verpamil, tamoxifen, chlorpromazine, amiodorone, chloroquine, st. john's wort * any unresolved chronic toxicity greater than ctc grade 2 from previous anticancer therapy * incomplete healing from previous oncologic or other major surgery patients may not be receiving any other investigational agents * history of allergic reactions attributed to compound of similar chemical or biologic composition to zd 1839 * uncontrolled intercurrent illness * pregnancy or breast feeding (women of child -bearing potential

Keywords: larynx lip oral cavity and pharynx
effect of ivabradine on heart rate & effort tolerance in mitral stenosis in sinus rhythm

Conditions: Mitral Stenosis

Summary: the purpose of this study is to study the effect of ivabradine vs atenolol on heart rate and effort tolerance in patients with mild to moderate mitral stenosis and normal sinus rhythm.


Eligibility criteria:
inclusion criteria: 1. mild to moderate mitral stenosis (mitral valve area: 1.0 cm2 - 2.0 cm2 on echocardiography) with normal sinus rhythm 2. age \>18 years 3. need for rate control therapy for symptoms exclusion criteria: 1. atrial fibrillation 2. other significant valvular lesions (more than mild as/ar/mr) 3. denial of consent 4. unable to do tmt/contraindication for tmt 5. need for surgical treatment or bmv 6. presence of significant non-cardiac co-morbidities 7. pregnancy
diagnostic accuracy of the preoperative clinical examination in upper limb injuries

Conditions: Penetrating Injury in Upper Limb

Summary: the purpose of this study is to determine the accuracy of preoperative clinical examination in penetrating injuries

penetrating injuries is a common cause of severe neurovascular damage, both in adults and children.we evaluated the accuracy of the preoperative clinical examination in depicting lesions caused by penetrating wounds of hands or forearms.

Eligibility criteria:
inclusion criteria: deep penetrating injury to upper limb exclusion criteria: none

Keywords: clinical examination, accuracy, hand, tendon, injury.
intraoperative disinfection by pulse irrigation with povidone-iodine solution in spine surgery

Conditions: Spinal Diseases; Spinal Fusion; Spine Injury; Infection, Hospital

Summary: the purpose of this study was to evaluate the efficacy, in preventing spinal surgical infection, of intraoperative pulsatile irrigation with a 2000-ml saline solution of pvp-iodine in a group of patients undergoing complex spine surgery with a posterior approach. to confirm and better assess the efficacy of intraoperative irrigation on the infection rate in spinal surgery, specimens for bacterial culture were harvested by swabs from muscular tissue before and after irrigation of the wounds

the investigators enrolled fifty patients undergoing spinal surgery were randomly divided in two subgroups (a and b) of 25 patients each. in subgroup a, wounds were irrigated with dilute (3%) povidone-iodine solution through a low-pressure pulsatile device. in subgroup b wounds were irrigated with normal saline solution thorough a bulb syringe. in both subgroup specimens for bacterial culture were harvested by swabs from surgical site before and after irrigation of the wounds.

Eligibility criteria:
inclusion criteria: * male and female * patients candidated to spinal surgery for spinal surgery * primary spinal surgery procedure exclusion criteria: * clinical signs of infection before surgery * previous spinal surgery

Keywords: pulse irrigation povidone iodine spine surgery