Kornimate/medical-research-clean huggingface dataset:
positron emission tomography (pet) study with [18f]azd4694 and [11c]azd2184, candidate pet ligands for aβ amyloid

Conditions: Alzheimer's Disease

Summary: the study is carried out in order to investigate if \[18f\]azd4694, compared to \[11c\]azd2184, is a suitable pet ligand for in vivo imaging of aβ amyloid depositions in the human brain. in the study the two pet ligands will be examined in both healthy volunteers and patients with alzheimer's disease. a whole body dosimetry scanning will be performed in 6 healthy volunteers to obtain human data to estimate a safe dose.


Eligibility criteria:
inclusion criteria: * alzheimer's disease patients - 50-85 years, mild to moderate ad: mmse ≥16 and ≤ 26, clinical progression of ad over 12 months. * healthy volunteers: - 50-75 years * bmi 18 and 30 m2/kg * clinically normal physical findings including supine blood pressure and pulse rate. exclusion criteria: * alzheimer's disease patients - clinically significant illness the 2 weeks prior to the administration of the pet ligand * significant cerebrovascular disease or depression, central nervous system infarct or infection or lesions * administration of any investigational product within 3 months prior to study and/or pet measurements for scientific purposes within the last 12 months. * healthy volunteers - clinically significant illness within 2 weeks before administration of pet ligand, history of psychiatric or somatic disease/condition that may interfere, first degree relative with dementia. obvious deterioration of memory functions.

Keywords: alzheimer's disease pet phase 1 positron emission tomography
ritgens maneuver for the prevention of anal sphincter tears at delivery: a randomized controlled trial

Conditions: Perineal Lacerations

Summary: the aim of the investigation was to assess whether routine use of the modified ritgen´s maneuver decreases the risk of anal sphincter injury at delivery, compared with simple manual protection of the perineum.ritgen´s maneuver means that the fetal chin is reached for between the anus and the coccyx and pulled anteriorly, while using the fingers of the other hand on the fetal occiput to control speed of delivery and keep flexion of the fetal neck.

this application is made retroactively - the study was performed during december 1st, 1999 to july 31st, 2001, at lund university hospital and helsingborg hospital. primigravid women in the area were informed about the study at the maternity care centers, receiving written information in gestational week 36. eligible for the study were women with singleton pregnancy and a fetus in cephalic presentation, admitted for labor, rupture of the membranes or induction after 37 completed gestational weeks. primigravid women received written information about the study at the maternal health care centers, and eligible women were asked for consent at admission in labor. randomization was done at the beginning of the second stage of labor (at full cervical dilatation), in each unit by a telephone call from the delivering midwife to the other department, where randomization lists with numbers for allocation were kept. in women allocated to ritgen´s maneuver, the protocol stated that the delivery of the fetal head should be managed by this maneuver, i.e. lifting the fetal chin anteriorly, using the fingers of one hand placed between the anus and the coccyx, and thereby extending the fetal neck, whereas the other hand should be placed on the fetal occiput to control the pace of the expulsion of the fetal head. the technique for ritgen´s maneuver was standardized, and midwives that were unfamiliar with the procedure were instructed by senior colleagues before the trial. in the other study group, the protocol entailed our standard care. the standard practice at delivery was using one hand to apply pressure against the perineum, and the other hand on the fetal occiput to control the expulsion of the fetal head, and only to use ritgen´s maneuver in case of labor arrest or abnormal fetal heart rate pattern when the fetal head was at the pelvic floor.

Eligibility criteria:
inclusion criteria: * women with singleton pregnancy and a fetus in cephalic presentation * admitted for labor * rupture of the membranes or induction after 37 completed gestational weeks * and reaching full cervical dilatation. exclusion criteria: * operative delivery

Keywords: sphincter tears ritgen maneuver perineal tears prevention delivery
laryngeal nerve block for chronic cough

Conditions: Laryngeal Nerve Block; Chronic Neurogenic Cough; Laryngeal Hypersensitivity

Summary: the purpose of this study is to study the potential benefit of treating chronic neurogenic cough by blocking the nerve responsible for the disease with an injection of local anesthetic/steroid mixture versus a placebo.

this study will be performed by asking participants to fill out multiple questionnaires on the symptoms of their cough, and undergo cough testing by inhaling an airway irritant and monitoring the number of coughs after inhalation of the irritant. subjects would then undergo the treatment and have an injection of either local anesthetic/steroid mixture or a placebo (normal saline) around the nerve that gives feeling to the portion of the voice box responsible for chronic neurogenic cough. after the injection you will be asked to repeat the cough testing and questionnaires 30 minutes, 1 weeks, and at 6 weeks post injection. after the initial six weeks, patients will cross over and repeat the same process with the opposite treatment (either local anesthetic/steroid mixture or placebo) from their previous injection. the total time of participation is about 12 weeks and we hope to recruit 40 subjects.

Eligibility criteria:
inclusion criteria: * 18 years and older * previously or newly diagnosed chronic neurogenic cough exclusion criteria: * history of laryngeal surgery or external beam radiation * current smokers * known allergy or sensitivity to local anesthetics * uncontrolled pulmonary, sinonasal, or gastrointestinal pathology leading to refractory chronic cough

Keywords: cough chronic cough neurogenic cough laryngeal nerve block
different concentrations of dextrose prolotherapy treatment in knee osteoartritis

Conditions: Knee Osteoarthritis

Summary: in this study, the investigators aimed to compare the efficacy of %5, %10 and %20 concentration dextrose prolotherapy (dpt) treatments in patients with primary knee osteoarthritis (oa). in this prospective, randomized, controlled, single-blind study, 128 patients who met the inclusion criteria were recruited and divided into four groups. thirty patients from each group completed the study. %5 dpt was applied to group 1, %10 to group 2, and %20 to group 3 in combination with home exercise program and hotpack therapy. group 4 was given home exercise program and hotpack therapy. groups were evaluated with vas (visual analog scale), womac (western ontario and mcmaster universities osteoarthritis index), knee rom (range of motion), and timed up and go test (tug) parameters. dpt groups were evaluated in terms of side effects.


Eligibility criteria:
inclusion criteria: * patients aged 40-70 years, * knee pain for more than three months, * diagnosed with primary knee oa according to acr clinical/radiological diagnostic criteria and kellgren-lawrence stage ii-iii. exclusion criteria: * total knee replacement * rheumatological diseases, systemic infection, and malignancy * pregnancy or breastfeeding * taking a nonsteroidal anti-inflammatory drug (nsaid) in the last week, taking steroid drugs in the last month * undergoing anticoagulant or immunosuppressive therapy * knee injection in the last 6 months
a comparison of mouth rinse containing alcohol-free chlorhexidine with a cetylpyridinium chloride in periodontal diseases

Conditions: Periodontal Diseases

Summary: aim: clinical effectiveness of 0.05% cetylpyridinium chloride mouth rinse in patients with gingivitis as compared to non-alcoholic chlorhexidine mouth wash. methods \& material: twenty-four subjects, without systemic diseases, with plaque-induced gingivitis will be selected for this study. the patients were treated with scaling and root planing at the baseline; oral hygiene instructions were given that included brushing twice- daily, the volunteers brushed their teeth with the bass brushing technique for at least 2 minutes, these patients were randomly ,equally divided into two groups, group a: perform daily mouthwashes twice a day with the solution containing 10 ml of 0.05 cetyl pyridinium, (vi-one, rojin, cosmetic-lab, kurdistan -iran), group b: use daily mouthwashes twice a day with 10ml of the chlorhexidine(kin laboratories, spain), on day 0,7,15 and day 21 of each phase the plaque index (pi), pocket depth(pd), stain index(si) and bleeding index (bi) of each volunteer were measured.

in this study, 34 patients referred to periodontics department that no serious systemic disease in terms of periodontitis and disease gingivitis (ie pockets of periodontal tissue to a depth of less than or equal to 4 mm without cal in the jaw down or up) the following explanation necessary for the procedure tastings consent, the index of oral hygiene (plaque index) index # turesky, pocket depth and to control the inflammatory condition \* bleeding index bleeding during the probe based on carter and barnes (if any bleeding number 1 and its absence 0) and attachment loss were evaluated areas. the amount of pigment (stain) after of using mouthwash based on s.i (stain index) was evaluated .

Eligibility criteria:
inclusion criteria:inclusion criteria: adult patients with gingivitis, older than 18 years old, systemically healthy, and having at least 20 teeth. exclusion criteria:patients with cavitated caries, no periodontal pockets larger than 4 mm, orthodontic appliances or removable prostheses, allergies to cetyl pyridinium or chx, use of antibiotics and anti-inflammatory drugs in the past 3 months that might alter normal gingival health, oral prophylaxis outside of study; use of oral chlorhexidine products or participation in an oral rinse study within 3 months prior to baseline examination, pregnancy or nursing, smoking. study population 34 eligibles were enrolled in the study, was designed as a randomized, double-blind clinical trials.
evaluation of salivary adseverin, 1-alpha defensin and srankl levels of individuals with different periodontal diseases

Conditions: Periodontal Diseases

Summary: : the aim of this study is; detection of adseverin,1-alpha defensin,srankl(soluble rankl) levels in saliva samples of periodontally healthy, gingivitis and periodontitis patients and the possible correlation between these values and clinical parameters of periodontal diseases. materials and methods: samples of saliva were obtained from 60 systemically healthy non-smoker individuals with periodontitis (p, n=20), gingivitis(g, n=20) and healthy periodontium (s, n=20). full-mouth clinical periodontal measurements including probing depth (pd), clinical attachment level (cal), bleeding on probing (bop), gingival index (gi) and plaque index (pi) were also recorded. enzyme-linked immunosorbent assay (elisa) was used to determine adseverin,1-alpha defensin,srankl(soluble rankl) levels in the biological samples.


Eligibility criteria:
inclusion criteria: systemically healthy (the determination of healthy volunteers will be based on the statements of the patients in the anamnesis. no additional examinations will be made.) at least twenty permanent teeth in the mouth non-smoker no medication for continuous use those who have not used antibiotics, anti-inflammatory and systemic corticosteroid drugs in the last 6 months. not in pregnancy or lactation period. for the periodontitis group that has not received periodontal treatment in the last 6 months for the periodontitis group; according to the evaluation made in 6 regions of each tooth, individuals with 30% or more bleeding on probing area, at least 2 teeth not adjacent to each quarter jaw with a depth of 5 mm or more and 4 mm or more attachment loss, coronal 1/3 and more on radiography (horizontal and / or vertical) bone loss for the gingivitis group; according to the evaluation made in 6 regions of each tooth, individuals with 10% or more bleeding on probing area, having a probing depth of less than 4mm and no attachment loss for healthy group; according to the evaluation made in 6 regions of each tooth,individuals with less than 10% bleeding on probing area, having a probing depth less than 4mm and no loss of attachment were included in the study. exclusion criteria: any oral or systemic disease regularly using a systemic medication during pregnancy or lactation received periodontal treatment within the last 6 months. those who received antibiotic, anti-inflammatory or systemic corticosteroid medication in the last 6 months smokers are not included in the study
efficacy of point of service testing in mbc

Conditions: Metastatic Cancer; Breast Cancer

Summary: this study will assess the efficacy of an innovative point of service cancer genetics counseling delivery model for metastatic breast cancer (mbc) patients whom have received a referral for hereditary cancer genetic counseling and testing.


Eligibility criteria:
inclusion criteria: * ability of participant or legally authorized representative (lar) to understand this study, and participant or lar willingness to sign a written informed consent. * able to speak and read in the english language. * have a diagnosis of human epidermal growth factor receptor 2 (her2) negative metastatic breast cancer. * participants must be enrolled in the parent registry study. exclusion criteria: * genetic testing for a breast cancer gene (brca) brca1 and brca2 mutation completed after 2013 or any brca 1 and brca2 testing with large rearrangement testing. prior genetic counseling is allowed. * psychiatric illness/social situations that would limit compliance with study requirements.

Keywords: genetic counseling
impact of covid-19 pandemic on epilepsy evaluations in the pediatric emergency department

Conditions: Epilepsy; Emergency Services, Hospital; COVID-19

Summary: background. seizures are a common cause of evaluation in the pediatric emergency department (ed). several studies about the impact of covid-19 pandemic on ed attendances report a considerable reduction in general pediatric care. the aim of our study was to evaluate the impact of covid-19 on the admission to the pediatric ed for seizures. materials and methods. we performed a retrospective study to assess the rate of ed admission for seizures at the pediatric ed of the fondazione irccs ca' granda ospedale maggiore policlinico of milan between january 2017 and december 2021, comparing the pre-pandemic (from january 2017 to february 2020) and pandemic periods (from march 2020 to december 2021).


Eligibility criteria:
inclusion criteria: * age: 1 months to 17 years * sex: all * with at least one access to the pediatric ed of the hospital for seizures exclusion criteria: * children who received a diagnosis of seizure on admission in triage that was not confirmed at discharge (breath-holding spell, fainting...).
longterm followup of patients with rheumatoid arthritis treated with methotrexate

Conditions: External Causes of Morbidity and Mortality

Summary: longterm followup of patients with rheumatoid arthritis 30 years after starting a baseline treatment with methotrexate.

objective. 30-year follow-up of rheumatoid arthritis (ra) patients treated with methotrexate (mtx) in the 1980s to analyze the association of the degree of response to mtx with long-term mortality. methods. in this observational cohort study, 271 ra patients who had started treatment with mtx between 1980 and 1987 were included (mean age 58 years, mean disease duration 8.5 years). one year after baseline, the treatment response to mtx was evaluated. responders were defined as patients with at least 20% improvement. thereafter, assessments were performed at 10 and 18 years after baseline. this re-evaluation was done to provide the data after 30 years of follow-up. standardized mortality ratios (smr) are calculated, cox regression and logistic regression are performed.

Eligibility criteria:
inclusion criteria: * rheumatoid arthritis * treatment with methotrexate * active disease exclusion criteria: * low disease activity * previous treatment with methotrexate
effect of exercise on insulin resistance

Conditions: Prediabetic State

Summary: the purpose of this study is to evaluate the effect of exercise on insulin resistance (ir) in subjects who do not routinely exercise and who are at risk of developing diabetes (prediabetes). it is estimated that approximately 30-90 people will participate in this study at three study sites in the united states and united kingdom.


Eligibility criteria:
inclusion criteria 1. aged 18 to 75 years. 2. meets one of the three diagnostic criteria listed below (based on screening results or recorded result within one week of enrollment); 1. fasting plasma or whole blood glucose (fasting defined as no caloric intake for at least 8 hours): 100 ≤ 125 mg/dl (6.0-6.9 mmol/l) 2. hba1c of 5.7% - 6.4% (39 - 46 mmol/mol) 3. 2-hour plasma glucose of 140-199 mg/dl (7.8-11.0 mmol/l) during an ogtt (as described by the who using a glucose load of 75 g anhydrous glucose dissolved in water) 3. no clinically significant adverse exercise response during the maximal graded exercise test exclusion criteria 1. weight loss diet program or weight change (\>10%) within the past 6 months 2. daily physical activity of \>10,000 steps per day (as measured during the interval between visits 1 and 2) 3. participates in deliberate structured exercise 4. pregnant or intending to become pregnant 5. cognitive or intellectual disability that prevents subject from providing informed consent or following protocol instructions. 6. unwillingness to participate in all study procedures 7. inability to give blood through multiple venous phlebotomies or to have an intravenous catheter 8. bmi greater than 40 kg/m2 9. concurrent participation in another lifestyle modification trial 10. diagnosis of diabetes based on any one of the following criteria: 1. fasting plasma or whole blood glucose ≥ 126 mg/dl (7 mmol/l) 2. hba1c of \>6.5% (\>47 mmol/mol) 3. 2-hour plasma glucose ≥ 200 mg/dl (11.1 mmol/l) during an ogtt 11. any pre-existing or newly discovered medical condition that is deemed likely to put the subject at risk of injury during this trial. this may include but is not limited to: 1. clinically relevant vascular or cerebrovascular event (e.g. stroke, recurrent transient ischemic attack (tia), deep venous thrombosis or intracardiac thrombi, clinically significant edema within the previous 6 months 2. current use of anti-psychotic, anti-convulsant, anti-coagulant, sedative medication, or cognition-enhancing medications 3. current use of beta blockers (beta-adrenergic blocking agents) 4. current or previous use (within the past year) of the following medications: diabetes related medications or insulin; metformin; growth hormone; glucagon; dipeptidyl peptidase-4(dpp-4) inhibitors (saxagliptin, stigagliptin); glucagon-like peptide-1(glp-1) mimetics (exenatide, liraglutide); sulfonylurea medication or other potential confounding medications 5. medical conditon which predetermines insulin resistance (e.g. marfan syndrome / severe polycystic ovary syndrome (pcos) / cushing syndrome etc.). 6. fasting triglycerides \> 1000 mg/dl.
consequences of obstructive sleep apnea syndrome (osas) after ischemic subtentorial stroke.

Conditions: Obstructive Sleep Apnea Syndrome; Brain Infarction

Summary: obstructive sleep apnea syndrome (osas) is associated with stroke as a risk factor but little is known about the consequences of osas on the outcome and the survival after stroke. the aim of the investigators study is first to evaluate the outcome and the survival of patients with stroke depending of osas (presence and severity of osas) and second to compare the outcome and survival of patients with severe osas depending on the treatment of the syndrome with nocturnal continuous positive airway pressure. the investigators hypothesis is that osas is associated with worst survival and outcome and needs to be treated at the subacute phase of stroke.

objective : the aim of our study is to evaluate the consequences of obstructive sleep apnea syndrome on the functional outcome and the survival after an ischemic stroke and to measure the impact of the treatment with continuous positive airway pressure on the outcome of patients with severe obstructive sleep apnea syndrome.patients and methods : we will prospectively explore by polysomnography, 300 consecutive patients hospitalized for an ischemic stroke in the stroke units of university hospitals at the sub acute phase after stroke (j15±4). 1) we will compare the functional outcome, the neurological impairment, the peripheral endothelial function, the continuous blood pressure measure on 24 hours recording, the quality of life and the survival at 3, 6 and 12 months in four groups of patients depending on their apnea/hypopnea index 2) in patients with severe obstructive sleep apnea syndrome, we will explore the impact on the functional outcome, the neurological impairment, and the survival at 3, 6 et 12 months of a treatment with continuous positive airway pressure (cpap) randomly compared to a treatment with sham cpap (non efficacious pressure) during 3 months. conclusion : this study should allow us to evaluate the consequences of obstructive sleep apnea syndrome on the outcome and the survival after ischemic stroke and the impact and the tolerance of the treatment with continuous positive airway pressure in patients with severe obstructive sleep apnea syndrome.

Eligibility criteria:
inclusion criteria: * brain infarction confirmed by brain imaging * follow up possible * severity at admission and at one week follow up: * nihss ≥ 4 or- isolated aphasia (item 9 ofnihss ≥ 1) or * negligence (item 11 du nihss ≥ 2) or * distal motor deficit (score ≥ 1) * health insurance affiliation * inform and free consent agreement

Keywords: obstructive sleep apnea syndrome survival ischemic stroke continuous positive airway pressure handicap
prehospital management of hypotensive trauma in hems

Conditions: Hypotension and Shock; Wounds and Injuries; Emergencies; Critical Care

Summary: up to today, inadequate evidences and knowledge exist about the best prehospital management of hypotensive trauma patients and its clinical consequence on the in-hospital recovery and mortality. also new emerging therapies such as prehospital blood transfusion and reboa (resuscitative endovascular balloon occlusion of the aorta) are lacking strong evidences in, eventually, reducing hospital mortality and improving outcomes. moreover, prehospital emergency medicine is throughout italy an heterogeneous system that has no unique standard operating procedures and, even among hems (helicopter emergency medical service), management and therapies on complex trauma patients may vary upon local policies. with this study we aim to enroll hypotensive trauma patients and study factors of prehospital rescue that can be associated with in-hospital mortality and recovery, eventually even with hospital outcome. for each patients data as demographic, kind of trauma (mechanism, injury scores), therapies and maneuvers will be recorded and then analyzed in comparison with in-hospital data such as need for transfusion, abg parameters, length of stay (in-ward and icu), need of therapies like invasive ventilation and renal replacement therapy, recovery and outcome


Eligibility criteria:
inclusion criteria: * age \> 18 years * witnessed traumatic event managed by hems * shock at first evaluation (systolic blood pressure \< 90 mmhg) * suspect or obvious ongoing haemorrage exclusion criteria: * patients in cardiac arrest at hems arrival in which resuscitation is not started or interrupted by hems crew

Keywords: transportation of patients wounds and injuries emergencies critical care