Kornimate/medical-research-clean huggingface dataset:
retrospective multi-center study to compare perioperative outcomes for robotic-assisted lobectomy with those associated with vats and open lobectomy for lung cancer

Conditions: Lung Cancer

Summary: the main objective of this study is to evaluate and compare peri-operative outcomes of lobectomy compare with different approaches. the study aims to include patients with stage ia, ib, iia, iib and iiia lung cancer that underwent lobectomy via robotic-assisted, vats and open approach.

this is a multi-center, retrospective chart review study of all consecutive lobectomies performed for clinical stage ia, ib, iia, iib and iiia lung cancer, performed by participating surgeons at their respective institutions that meet all inclusion and exclusion criteria. all cases of lobectomy performed for clinical stages, ia, ib, iia, iib and iiia lung cancer via robotic-assisted, vats (video assisted thoracic surgery) and open approach that meet the study inclusion and exclusion criteria will be considered for inclusion in the study. the chart review and data collection will be performed in a reverse chronological order starting at 30 days prior to irb approval of the study at the institution and going back to 2013 (i.e most current data in 2017 and chronologically going back through 2013). the retrospective chart review and data collection is anticipated to occur in two phases: baseline patient characteristics, perioperative and post-operative short term clinical and pathological outcomes data will be obtained from hospital records. each participating institution will contribute approximately 100-800 cases from one or more surgeons. since the data will have been de-identified, and is archival in nature, there will be no active subject recruitment and no patient consenting is required

Eligibility criteria:
inclusion criteria: * subject is 18 years or older * subject who has undergone elective robotic-assisted, vats or open lobectomy for clinically diagnosed primary stage ia, ib, iia, iib and iiia lung cancer, with or without neo-adjuvant therapy exclusion criteria: * subject with stage iiib lung cancer * subject who received lobectomy as an emergent procedure * subjects who received lobectomy for metastatic cancer
effectiveness of nebulized hypertonic saline and epinephrine in hospitalized infants with bronchiolitis

Conditions: Bronchiolitis

Summary: acute bronchiolitis is the main cause for respiratory illness that requires hospitalization in children younger than 2 years. in the united states it has been shown that the burden of the disease is considerable, having an annual cost of more than $ 500 million and being responsible for the 17% of all infant hospitalizations . aim of the present study was to verify the effects of nebulized 3% saline solution in comparison to normal saline in addiction to epinephrine in a large population of rsv positive cases of bronchiolitis; all patients presented a disease as much as severe to require hospitalization.the main study endpoints were the length of stay in hospital and the clinical response.

among 136 patients assessed within 12 hours for entry into the study, 109 (69 males) accepted to participate, gave an informed consent and were randomly assigned either to receive every 6 hours the nebulized 0.9% saline (ns) (group i) or the 3% hs (group ii) in addition to aerosolized epinephrine (1.5 mg) and to the conventional treatment (oxygen, fluids). patients were randomized to receive different saline treatments using a computer-based randomization program. study solutions, prepared by the local hospital pharmacy, were blinded to participants and investigators. each treatment was delivered by a nebulizer with continuous flow of oxygen at 6 l/min through a tight-fitting facemask. the main study endpoints were the length of stay (los) in hospital and the clinical response. los in hospital was defined as the time between study entry (within 12 hours of admission to the hospital) and the time at which the infant was discharged on the basis of the clinical grounds by the attending physician. clinical response was determined using daily css evaluation; furthermore, the css was evaluated every day before and 30 minutes after nebulisation.

Eligibility criteria:
inclusion criteria: * children aged less than 2 years old * clinical diagnosis of bronchiolitis exclusion criteria: * cardiac or pulmonary diseases * premature birth \< 36 weeks of gestational age * previous diagnosis of asthma * an initial oxygen saturation of 85%

Keywords: bronchiolitis, 3% hypertonic saline solution
outcome measures for pediatric wheelchairs in low-resource settings

Conditions: Shoulder Impingement; Pressure Ulcer

Summary: two wheelchair types available for children in kenya are assessed for energy costs, utility, and complications. this study will arrive at a protocol for assessing wheelchairs in low-income settings, and in the process, provide wheelchair makers and providers with specific feedback. it also serves as a means to increase the skills of local health professionals working with the children in this study, while providing them with appropriate wheelchairs to use.

in each of 2011, 2012, and 2013, two different low cost wheelchairs were assessed. user feedback, health professional feedback, and objective measures were employed for these assessments in the real world setting. participants for each phase were recruited from a kenyan primary or secondary schools for children with disability.

Eligibility criteria:
inclusion criteria: * children who would benefit from available study wheelchairs who are able to provide feedback exclusion criteria: * children who are not able to provide feedback on the study wheelchairs

Keywords: pediatric wheelchairs low-income comparisons
diabetes group prenatal care

Conditions: Pregnancy; Gestational Diabetes; Type 2 Diabetes

Summary: the investigators primary objective is to conduct a pilot randomized trial to determine the effect of group prenatal care on self-care activities in women with diabetes.

long term, the investigators aim to test the central hypothesis that group prenatal care, compared to traditional prenatal care, will improve glycemic control and, ultimately, maternal and neonatal outcomes in women with type 2 and gestational diabetes. the objective of this proposal is to conduct a pilot randomized trial to determine the effect of group prenatal care on self-care activities, which have been associated with improved glycemic control, in women with diabetes.

Eligibility criteria:
inclusion criteria: * english (wumc) or spanish speaking (dh) * type 2 white's class b diabetes or gestational diabetes diagnosed by 2-step method \< 32 weeks * ability to attend group prenatal visit at specified days and times * willingness to be randomized * randomization at 22 weeks 0 days-32 weeks 0 days * ability to give informed consent exclusion criteria: * multiple gestation * major fetal anomaly * serious medical co-morbidity necessitating more care than can be safely provided in group setting, as deemed by medical provider * serious psychiatric illness including schizophrenia necessitating more care than can safely be provided in group setting, as deemed by medical provider

Keywords: group prenatal care centeringpregnancy diabetes
a long-term extension trial from of spm 962 in advanced parkinson's disease patients

Conditions: Parkinson's Disease

Summary: * to investigate the safety of once-daily repeated transdermal administration of spm 962 within a dose range of 4.5 to 36.0 mg/day (54-week treatment period) in parkinson's disease (pd) patients treated concomitantly with l-dopa in a multi-center, open-label uncontrolled study. * to investigate efficacy of spm 962 in an exploratory manner.


Eligibility criteria:
inclusion criteria: * subject completed the preceding trial 243-08-001. exclusion criteria: * subject discontinued from the preceding trial 243-08-001. * subject had a serious adverse event which association with the investigational drug was not ruled out during trial 243-08-001. * subject has a persistent serious adverse event at the baseline, which was observed and association with the investigational drug was ruled out during trial 243-08-001. * subject had persistent confusion, hallucination, delusion or excitation during trial 243-08-001. * subject has abnormal behavior such as obsessive-compulsive disorder and delusion in 243-08-001 study. * subject showed serious or extensive application site reactions beyond the application site in the 243-08-001 study. * subject has orthostatic hypotension or a systolic blood pressure (sbp) \ = 30 mmhg at baseline. * subject has a history of epilepsy, convulsion etc. during trial 243-08-001. * subject develops serious ecg abnormality at the baseline. * subject has qtc-interval \>= 500 msec at the baseline or subject has an increase of qtc-interval \>= 60 msec from the baseline in the trial 243-08-001 and has a qtc-interval \> 470 msec in female or \> 450 msec in male at the baseline. * subject had a serum potassium level \< 3.5 meq/l at the end of the taper period in trial 243-08-001. * subject has a total bilirubin \>= 3.0 mg/dl or ast(got) or alt(gpt) greater than 2.5 times of the upper limit of the reference range (or ? 100 iu/l) at the end of the period in trial 243-08-001. * subject had bun \>= 30 mg/dl or serum creatinine \>= 2.0 mg/dl at the end of the taper period in trial 243-08-001. * subject who plans pregnancy during the trial. * subject is unable to give consent. * subject is judged to be inappropriate for this trial by the investigator for the reasons other than above.

Keywords: spm 962 rotigotine parkinson's disease concomitant use of l-dopa
effects of oxytocin on negative symptoms and social cognition in schizophrenia and its possible mechanisms

Conditions: Schizophrenia

Summary: the purpose of this study was to investigate the effects of oxytocin on negative symptoms and social cognitive task performance in schizophrenia. the investigators conducted a randomized, placebo-controlled trial testing the effects of twice daily intranasal oxytocin treatment for 14 days on psychotic symptoms and social cognition in patients with schizophrenia. the investigators hypothesize that panss scores will decline significantly and several social cognition measures will improved significantly or nearly significantly in oxytocin but not placebo recipients.

social impairment is a primary cause of disability in schizophrenia, responds poorly to current antipsychotic medications and is related to deficits in social cognitive abilities, which include theory of mind, emotion recognition and attributional style. oxytocin (ot) has many pro-social effects in animals and antipsychotic-like efficacy in preclinical tests. in this study, the investigators conducted a randomized, placebo-controlled trial testing the effects of twice daily intranasal oxytocin treatment for 14 days on psychotic symptoms and social cognition in patients with schizophrenia. the investigators will recruit patients with schizophrenia, screening of subjects included a review of psychiatric and medical history, physical examination, baseline social cognition measures were obtained followed by psychiatric ratings. daily intranasal treatments were initiated after baseline assessments. social cognition measures and psychiatric ratings were repeated beginning 50 min after the morning dose of study medication on treatment day 14. psychiatric ratings include the positive and negative syndrome scale (panss) and the clinical assessment interview for negative symptoms (cains). the social cognition instruments are some social scales such as toronto alexithymia scale, the interpersonal reactivity index(iri), and some computer tests such as reinforcement learning task and facial emotion identification test.

Eligibility criteria:
inclusion criteria were: 1. aged between 18 and 55 years; 2. dsm-iv diagnosis of schizophrenia, acute schizophreniform disorder, or schizoaffective disorder. exclusion criteria were: 1. presence of other psychiatric diagnoses (e.g., depression); 2. active misuse of substance or alcohol; 3. intellectual disability (iq \< 70); 4. a history of neurological disorder.

Keywords: schizophrenia negative symptoms oxytocin
application of intravitreal conbercept injection as a primary treatment for exudative circumscribed choroidal haemangioma

Conditions: Circumscribed Choroidal Haemangioma

Summary: the aim of this study was to investigate the safety and effectiveness of application of intravitreal conbercept injection as the primary treatment for exudative circumscribed choroidal haemangioma.

this prospective clinical trial aims to evaluate the safety and effectiveness study of intravitreal conbercept injection as the primary treatment for exudative circumscribed choroidal haemangioma: (1)to evaluate therapeutic effect (including both anatomical and functional responses to intravitreal conbercept injection) of intravitreal conbercept injectionfor exudative circumscribed choroidal haemangioma; (2)to evaluate the safety (including side effects of the eye as well as side effects of system) of intravitreal conbercept injection for exudative circumscribed choroidal haemangioma.

Eligibility criteria:
inclusion criteria: * 1) patients with circumscribed choroidal haemangioma who was diagnosed using ophthalmoscopy, fluorescein/indocyanine green angiography, and ultrasonography; 2) presence of reduced visual acuity or metamorphopsia; and 3) subretinal fluid involving the fovea. exclusion criteria: * patients with abnormal liver function test results, liver disease, porphyria, or previous treatment for circumscribed choroidal haemangioma.

Keywords: circumscribed choroidal haemangioma conbercept effectiveness safety
neck posturing in surgeons during microsurgery procedures using upright go 2 device

Conditions: Neck Pain Musculoskeletal

Summary: consultant and senior registrars performing microsurgery will be invited to participate in this study. the study will take place at single site (beaumont hospital). a questionnaire to collect demographic information (age, height, sex, year of training, prior neck trauma or know neck issues) will be given to the consented surgeons. additionally, surgery characteristics will be recorded (procedure, surgeon role (i.e lead or assisting), table height, frequency of adjustment of table height, and use of sitting or step stool, headlight, and/or loupes for \>50% of the procedure). a postural training device, upright go 2 will be positioned at the spinous process of the cervical vertebrae of each surgeon and used to measure neck positions during microsurgical procedures. the device will be calibrated to an ideal neutral cervical spine position, so that excessive flexion and extension of the neck can be recorded. the device contains built-in sensors that provide bio-feedback in the form of gentle vibrations if posture has deviated from neutral position. during the first stage of the study the device will be set to record cervical spine positioning without bio-feedback signals. this will be used to record duration of time surgeons held maladaptation postures. the second stage will involve real-time feedback through the device. for surgeons who consent, bio-feedback signals will be given once deviated from a neutral posture for \>1 minute. response of surgeons to bio-feedback signals will also be recorded. the neck disability index score will be used to assess for neck pain and the functional implications in relation to reported neck pain. this will be completed following study completion.


Eligibility criteria:
inclusion criteria: * plastic and reconstructive surgeons performing microsurgery * consultants, registrars, and senior house officers with no prior cervical spine surgery or cervical degeneration exclusion criteria: * surgeons not performing microsurgery on a regular basis (at least once a month) * plastic and reconstructive surgery trainees with \<1 years experience in microsurgery.
application of a prediction model for directing antibiotic use in the treatment of urinary tract infection in an ambulatory setting

Conditions: Urinary Tract Infections

Summary: urinary tract infection (uti) is when bacteria enter the urinary system and cause an infection. utis cause symptoms including burning when peeing, a feeling of an increased urge to pee, and cloudy or strong-smelling urine. sometimes, severe utis can also cause fever, abdominal pain, and/or lower back pain. in the emergency department (ed), healthcare providers rely on symptoms, along with a urine analysis and a urine culture to diagnose a uti. a urine analysis involves taking a sample of urine and analyzing different factors like color, acidity, presence of blood cells, presence of bacteria. an abnormal urine analysis increases the likelihood that patients might have a uti, but it does not confirm it. a positive urine analysis will lead to provider's sending a sample of urine for a urine culture. a urine culture is used to grow whatever bacteria is in the collected urine. if growth is seen on the culture, then this confirms a patient has a uti. this also specifies which bacteria grew on the culture. the lab can also take it a step further and do an antibiotic test to check which antibiotic the bacteria is sensitive to. when a urine analysis comes back abnormal in an er setting, patients are prescribed an antibiotic before the culture and antibiotic sensitivity tests come back. if a patients condition is not critical, they will be discharged home before the culture results come back. if the culture comes back positive, the pharmacists will evaluate the culture and antibiotic sensitivity tests, then call patients to inform them whether they are taking a suitable antibiotic. this study aims to decrease the unnecessary use of antibiotics because this contributes to antibiotic resistance which is considered a global public health issue. antibiotic resistance occurs when bacteria develop the ability to withstand certain antibiotics that used to be effective against them, which makes it difficult to treat the infection. one of the factors that increase the risk of antibiotic resistance is the overuse of antibiotics. in this study, investigators will be incorporating a prediction model and a negative callback system to decrease unnecessary antibiotic use.


Eligibility criteria:
inclusion criteria: * female sex * age \>18 years old * discharged from the hospital after er visit * discharge icd code consistent with a uti diagnosis * antibiotic prescribed for uti at the time of discharge exclusion criteria: * male sex * necessity for chronic bladder catheterization or discharge with a urinary catheter * patients who have an emergency severity index (esi) of 1 and 2 * patients who verbalize to the study team member that their pain is a 6 or higher * patient set to be transferred to inpatient care * history of bladder augmentation * pregnancy (this will be confirmed with a negative pregnancy test which is ordered in the er)

Keywords: er visits antibiotic use
a service-learning program for comprehensive geriatric assessment and health promotion in older adults

Conditions: Frailty; Older People; Comprehensive Geriatric Assessment; Health Promotion; SERVICE LEARNING; Students; Student Education

Summary: the geros project aims to develop and implement a service-learning (s-l) program that integrates comprehensive geriatric assessment (cga) and health promotion, for students at the faculty of health sciences and welfare at the university of vic - central university of catalonia (uvic-ucc). this initiative engages university students, healthcare professionals, and older adults (60+) in a participatory, intergenerational approach that fosters mutual learning and community engagement. the study follows a non-experimental mixed-method design, involving students from nursing, physiotherapy, human nutrition and dietetics, occupational therapy, and psychology. participants include older adults (60+) who can independently travel to the university. the project is integrated into different subjects, in groups of 4-5 students, participants conduct a comprehensive geriatric assessment (cga), evaluating frailty using vig-frail, intrinsic capacity with icope, quality of life with euroqol 5d-5l, and specific health indicators with nursing outcomes classification (noc). to assess the program's effectiveness, several outcome measures will be analyzed including students' perceived knowledge, competencies, and skills, as well as older adults' awareness of their health status, lifestyle, and risk factors. additionally, the satisfaction levels of both will be evaluated. the items will be evaluated using a 1-5 likert scale, and the analysis will be conducted with spss. data recording will be carried out through redcap. the geros project aligns with the united nations' sustainable development goals (sdgs), specifically sdg 3 (good health and well-being) and sdg 10 (reduced inequalities). by offering care to the aging population and providing them with personalized health recommendations, the project promotes preventive strategies, active aging, and intergenerational learning. furthermore, geros integrates innovative educational methodologies, encouraging experiential learning, collaboration with healthcare professionals, and the development of practical skills in real-world contexts. the program's scalability and adaptability could serve as a model for other universities and healthcare institutions aiming to enhance geriatric care through service-learning initiatives.


Eligibility criteria:
inclusion criteria: a) for users: * any person aged 60 or older who can move to the facility (faculty of health sciences and welfare) independently or accompanied by a caregiver. b) for students: * students from nursing, physiotherapy, nutrition and dietetics, occupational therapy and psychology degrees of uvic-ucc. exclusion criteria: * for users: individuals institutionalized in a long-term care institution.
teres major muscle and subacromial impingement syndrome

Conditions: Trigger Points in Teres Major Muscle; Subacromial Impingement Syndrome

Summary: there is not a clear understanding of the origin of symptoms perceived by patients with impingement of the soft tissue structures of the subacromial space. tendinopathy, tendon rupture or other pathologies, are present in asymptomatic subjects and subjects with symptoms and structural integrity can also be found. patients diagnosed with subacromial impingement syndrome frequently have myofascial trigger points in the teres major muscle. travell and simons reported that the symptoms caused by trigger points in this muscle are similar to those experienced by patients diagnosed with impingement syndrome, but a literature search provides few results regarding relationship between subacromial impingement syndrome and presence of myofascial trigger points in the teres major muscle. this study aims to provide evidence of the results that can be obtained with a specific approach of teres mayor muscle by two manual techniques, trigger point pressure release and diacutaneous fibrolysis, in subjects with subacromial impingement syndrome, a condition that still representing both a diagnostic and therapeutic challenge. secondary objective is to compare the outcomes between both techniques to select for each patient the most appropriate to their needs and characteristics.


Eligibility criteria:
inclusion criteria: * age 18 years and over * clinical diagnosis of subacromial impingement syndrome. * detectable trigger points in teres major muscle. * sign informed consent form. exclusion criteria: * diacutaneous fibrolysis contraindications * previous shoulder surgery (\<1year) * language barriers or cognitive issues that limit their ability to provide informed consent and participate in research. * patients with a pending litigation or court claim.