Kornimate/medical-research-clean huggingface dataset:
functional training improves the functional capacity and physical fitness of people whit spinal cord injury

Conditions: Physical Exercise; Disability Physical

Summary: the aim of this study is to understand the effect of adapted functional training on the physical fitness, functionality and quality of life of individuals with sci after social distancing due to covid-19. the main question\[s\] it aims to answer are: * are the participants of the functional training program adapted for people with spinal cord injury show better results in functional capacity in post-test evaluations training period, when compared to your results in the functional training pré-period? * is adapted functional training capable of improving cardiorespiratory fitness, muscular strength and body composition? * can the perception of quality of life be influenced by functional training? participants will be evaluated through questionnaires and field tests, such as: * functional capacity (battery of motor tests related to functional independence and motor assessment scale), * physical fitness (handgrip test; medicine ball throw; illinois agility and 12-minute displacement) and quality of life (whoqol-dis).

the spinal cord is an important component of the central nervous system, whose function is to transmit motor nerve impulses from the brain to other parts of the body, and to transmit sensory impulses from other systems of the body to the brain. among adults living with sci, studies show that participation in physical exercise programs, such as functional training, is associated with numerous health-related benefits, including improvements in cardiorespiratory fitness, energy production, and muscle strength, reduced the risk of cardiometabolic diseases and osteoporosis, in addition to psychosocial and quality of life benefits. however, high rates of physical inactivity among people with sci are still a reality and, therefore, a cause for medical and health concern. in the recent scenario, measures to prevent and contain covid-19 further contributed to the increase in sedentary time and behavior among individuals with spinal cord injury. considering that tf aims to enhance specific actions in activities of daily living, the hypothesis of the cohort study is that a positive effect will be observed on functional capacity, on elements of physical fitness of these individuals and on quality of life after 8 weeks of training functional. participants will be recruited by convenience and will undergo assessments of body composition, functional capacity, physical fitness and quality of life pre and post eight weeks of functional training, three times a week.

Eligibility criteria:
inclusion criteria: * men and women; * aged 18 or over * have had spinal cord injury for at least two years * wheelchair users exclusion criteria: * individuals who had clinical or physical conditions that prevented them from carrying out the proposed tests

Keywords: rehabilitation spinal cord injury physical disability physical training.covid-19
intimacy-enhancing couples' intervention for localized prostate cancer

Conditions: Prostate Cancer; Sexual Dysfunction and Infertility; Sexuality

Summary: rationale: participating in a therapy program may enhance communication and intimacy between men with prostate cancer and their partners. purpose: this randomized clinical trial is studying how well therapy enhances communication and intimacy for men with early stage prostate cancer and for their partners.

aim 1 a. to evaluate the impact of an intimacy-enhancing couples' intervention (iec) versus a general health and wellness intervention (ghw) and a usual care control (uc) on patient and partner psychological and relationship outcomes. b. to determine whether relationship length, pre-intervention relationship satisfaction, and men's pre-intervention masculinity moderate the effects of iec on couples' psychological and relationship outcomes aim 2 a. to evaluate whether iec has an effect on couples' communication and intimacy when compared with ghw and uc and to determine whether changes in relationship communication and intimacy mediate changes in couples' psychological and relationship outcomes. exploratory aim: a. to evaluate the impact of iec versus ghw on physical activity and fruit and vegetable intake as well as each partner's support for the other partner's adoption of greater physical activity and more fruit and vegetable intake.

Eligibility criteria:
inclusion criteria: * patient has a primary diagnosis of localized prostate cancer (t1, t2, n=0 m=0, t3 n=0 m=0) * patient had surgery or initiated radiation treatment (brachytherapy or external beam radiation) or began pre-radiation androgen deprivation therapy within the past 12 months. * patient is currently married or living with a partner, with relationship duration at least 1 year * patient and partner live within a 1 hour commuting distance to recruitment site * patient and partner read and speak english * patient has an impact of events scale (ies) score greater than or equal to 16 and/or partner has an ies score greater than or equal to 17. exclusion criteria: * patient had a previous definitive treatment for prostate cancer * patient has a concurrent diagnosis of another cancer (other than non-melanoma skin cancer) * partner is diagnosed with cancer (other than non-melanoma skin cancer) * patient or partner have a significant hearing impairment
augmented reality navigation system (endosight) for the guidance of bone biopsy

Conditions: Bone Lesion; Bone Tumor; Bone Infection

Summary: the goal of this clinical study is to evaluate the duration of the procedure, the precision (distance between the needle tip and the centre of the target), and the safety of endosight system in the guidance for bone biopsies.

in this study results obtained in the prospective group will be compared with those obtained in the retrospective group. total n° of patients: 16 prospective group (treated with the guidance of endosight): n° of patients: 8 retrospective group (treated without the guidance of endosight): n° of patients: 8 main objective of the study: reduction of execution times by at least 10 minutes; reduction of the number of ct scans by at least 2 scans. n°of hospitals involved: 2. duration: maximum 6 months from the date of the first enrollment. no follow-up is expected.

Eligibility criteria:
inclusion criteria: * patient with a bone lesion for which a percutaneous biopsy is indicated; * informed consent signed by the patient for participation in the study. exclusion criteria: * age \< 18 years; * pregnant and lactating women (assessed through auto declaration of the patient)
cognitive functioning in adults with somatic diseases and general population from a biopsychosocial perspective

Conditions: Aphasia; Development, Human; Neuropathology

Summary: the goal of this observational study is to investigate cognitive functioning profiles in adults with neurologically recognized aphasic syndromes and general population. the study group consist of minimal 600 adults (over 18 y.o.) who will be examined by qualified diagnosticians. participants will be evaluated with tasks related to the studied variables: memory, learning and language. furthermore informations regarding past and present health condition will be collected from participants. the main questions it aims to answer are: 1. what is the profile of memory and learning among polish adults? 2. do gender and age moderates patterns of memory and learning functioning among polish adults? 3. what is a specific pattern of language functioning in adults with neurologically recognized aphasic syndromes? 4. do gender moderates specific patterns of language functioning in adults with neurologically recognized aphasic syndromes? researchers will compare the following groups of adults: 1. general population/control group 2. with neurologically recognized aphasic syndromes 3. seniors (over 60 y.o.)


Eligibility criteria:
inclusion criteria for general population/control group: * age from 18 to 60 y.o. inclusion criteria for neurologically recognized aphasic syndromes * age above 18 y.o. * neurologically recognized aphasic syndromes inclusion criteria for seniors: * age above 60 y.o. exclusion criteria for general population/control group: * age less then 18 y.o. * neurologically recognized aphasic syndromes exclusion criteria for neurologically recognized aphasic syndromes * age less then 18 y.o. * no neurologically recognized aphasic syndromes exclusion criteria for seniors * age less then 60 y.o. * diseases of the nervous system, such as: stroke, craniocerebral trauma, neuroinfections, neurodegenerative diseases * mental disorders such as depression, psychotic disorders, anxiety disorders, addictions

Keywords: aphasia memory learning language adults seniors
development and validation of a ct-based diagnostic models using artificial intelligence for detection of small bowel obstruction

Conditions: Small Bowel Obstruction

Summary: small bowel obstruction (sbo) is a common non-traumatic surgical emergency. all guidelines recommend computed tomography (ct) as the first-line imaging test for patients with suspected sbo. the objectives of ct are multiple: (i) to confirm or refute the diagnosis of gi obstruction, defined as distension of the digestive tracts greater than 25 mm, and, when sbo is present, (ii) to confirm the mechanism (mechanical vs. functional), (iii) to localize the site of obstruction, i.e., the transition zone (tz), (iv) to identify the cause, and (v) to look for complications such as strangulation or perforation, influencing management. given the exponential increase in the number of scans being performed, especially in the setting of emergency management, methods to assist the radiologist would be useful to: 1. sort the scans performed, allowing prioritization of the analysis of scans with a higher probability of pathology (occlusion in our case) 2. help the radiologist to diagnose occlusion and its type (functional or mechanical), and to identify signs of severity. 3. to help the emergency physician and the digestive surgeon to make a decision on the management of the disease (surgical or medical). machine learning has developed rapidly over the last decades, first thanks to the increase in data storage capacities, then thanks to the arrival of parallel processing hardware based on graphic processing units, in the context of radiological diagnostic assistance. consequently, the number of studies on deep neural networks in medical imaging is increasing rapidly. however, few teams focus on sbo. the only published classification models have been produced for standard abdominal radiographs. no studies have used ct or 3d models, apart from our preliminary study on zts, despite the recognized advantages of ct for the diagnosis of sbo and the likely contribution of 3d models, which may be comparable to that of multiplanar reconstruction for the analysis of images in multiple planes of space.


Eligibility criteria:
inclusion criteria: * patient whose age ≥ 18 years * patient who has had a ct scan with at least one abdominal-pelvic acquisition performed within the saint joseph hospital group * report containing the terms "occlusion" or "occlusive", "vomiting" or "ileus" * french-speaking patient exclusion criteria: * imaging not usable * absence of abdomino-pelvic volume on ct acquisitions * patient under guardianship or curatorship * patient deprived of liberty * patient under court protection * patient objecting to the use of his data for this research
fenofibrate for prevention of dr worsening

Conditions: Diabetic Retinopathy

Summary: this randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy (dr) worsening through 6 years of follow-up in eyes with mild to moderately severe non-proliferative dr (npdr) and no ci-dme at baseline. in addition to evaluating efficacy, this study aims to evaluate the feasibility of a model for ophthalmologists to prescribe or collaborate with a primary care provider such as an internist/endocrinologist to prescribe and monitor the drug safely. if this study demonstrates that fenofibrate is effective for reducing the onset of proliferative diabetic retinopathy (pdr) or and the results are adopted by the community of retina specialists, a new strategy to prevent vision threatening complications of diabetes could be widely adopted. widespread use of an oral agent effective at reducing worsening of dr would decrease the numbers of patients who undergo more invasive and much more expensive treatment for dr and who are consequently at risk for side effects that adversely affect visual function. this study will also assess the relationship of glycemic variability, as measured by continuous glucose monitoring with dr outcomes. ancillary studies will characterize functional and structural outcomes in this cohort.


Eligibility criteria:
key inclusion criteria * age ≥18 years and \< 80 years. * type 1 or type 2 diabetes. * at least one eye with the following: * mild to moderately severe npdr (defined by etdrs dr severity level 35 to 47), confirmed by central reading center grading of fundus photographs. * best-corrected e-etdrs visual acuity letter score of ≥74 (approximate snellen equivalent 20/32 or better). if best corrected letter score is 74-78, investigator must verify that vision loss is not due to the presence of ci-dme, cataract, or other condition that may affect visual acuity during the course of the study. * if only one eye is eligible, the non-study eye must have at least microaneurysms only (dr severity level 20) key exclusion criteria eye-level exclusion criteria (the eye is ineligible if any of the following is met): * current ci-dme based on clinical exam or oct central subfield thickness (cst) * zeiss cirrus: cst ≥290 µm in women or ≥ 305 µm in men * heidelberg spectralis: cst ≥305 µm in women or ≥320 µm in men * any prior treatment for dme or dr, other than focal/grid laser. if the eye has a history of focal/grid laser, it must be at least 12 months prior. * history of intraocular anti-vegf or corticosteroid treatment within the prior year for any indication participant-level exclusion criterion (the participant is ineligible if the following criterion is met): • decreased renal function, defined as requiring dialysis or central laboratory egfr value \< 45 ml/min/1.73 m2

Keywords: fenofibrate non-proliferative diabetic retinopathy
hypofractionated radiation therapy in patients with breast cancer

Conditions: Breast Cancer

Summary: the investigators at pgimer have been practicing hypofractionation radiotherapy with a dose of 35gy/15#/3wks to the chest wall in post mastectomy and 40gy/16#/3wks in breast conservation in breast cancer patients for the last 4 decades. it is also a routine practice in uk and few centers in canada. hypofractionation reduces treatment time to half while maintaining cosmesis and gives control rates equal to conventional fractionation. as breast cancer is a leading cancer in females and radiation therapy is an important part of its local management, hypofractionation help the radiation centers worldwide to meet the growing need for radiation in breast cancer, particularly in developing countries where resources are limited. it also reduces the financial burden on the patient and family. in this study the investigators want to reduce the treatment duration from 3 weeks to 2 weeks. the study will include 1000 patients, 500 in each arm, with breast cancer post mastectomy or after breast conservative surgery to be treated with a radiotherapy dose of 34gy in 10 fractions over 2 weeks in the study arm and 35gy in 15 fractions over 3 weeks in the control arm. the primary endpoint of the study will be ipsilateral local tumour control. secondary endpoints will be early and late adverse effects in normal tissues, quality of life, contralateral primary tumours, regional and distant metastases and survival.

patients to be included in this study will be pre-operatively staged according to american joint committee on cancer (ajcc) 7th edition, international union against cancer ( which uses tnm staging ) as stage i-iii of breast carcinoma. total 500 patients of histologically proven post lumpectomy/mastectomy cases of carcinoma breast suitable for radiotherapy will be enrolled in this study. patients would be evaluated at the department of radiotherapy pgimer, chandigarh by doing a thorough clinical examination followed by routine investigations which will include hemogram, liver function tests, kidney function tests, chest x-ray. patients will be treated by standard rectangular tangential fields.

Eligibility criteria:
inclusion criteria: * invasive carcinoma of the breast * breast conservation surgery or mastectomy * axillary staging \&/or dissection * complete microscopic excision of primary tumour * pt1-3 pn0-2 m0 disease * written informed consent * able to comply with follow up exclusion criteria: * past history of malignancy except (i) basal cell skin cancer and cin cervix uteri or (ii) non-breast malignancy allowed if treated with curative intent and at least 5 years disease free * contralateral breast cancer, including dcis, irrespective of date of diagnosis * breast reconstruction using implants * concurrent cytotoxic chemotherapy (sequential neoadjuvant or adjuvant cytotoxic therapy allowed)

Keywords: breast cancer hypofractionated radiotherapy hypofractionated radiation
gastric outlet obstructions tailored covered stents for goo

Conditions: Gastric Outlet Obstruction

Summary: gastric outlet obstruction tailored versus standard stents for malignant gastric outlet obstruction treatments

to determine the shape of the goos, stomach opacifications were performed using contrast media before stenting. in the goo tailored group (33 cases), the distal stents were semi-spherical with a length of 20 mm and a diameter of 28 mm. the middle stent segments had diameters of 20 mm. the proximal ends of large cup-shaped stents had 53.3 ± 5.5 mm diameters and were 15 or 20 mm long, whereas the large funnel-shaped stents had 33.6 ± 3.6 mm diameters and were 25 or 30 mm long. the control group (32 cases) received standard uncovered stents (semi-spherical, with diameters of 28 mm and 20 mm long).our hypothesis was that unresectable goo tailored covered stents are superior to the standard uncovered ones in terms of stent re-obstruction and stent migration. in the current study the efficacy and safety of goo tailored covered stents for the treatment of non-resectable goos caused by distal gastric cancer was compared with standard uncovered stents.

Eligibility criteria:
inclusion criteria: goo defined by symptoms resulting in decreased oral intake (nausea, vomiting and inability to eat),the obstruction was caused by primary distal stomach cancer and the site of stenosis was between the gastric body and duodenum bulb exclusion criteria: the presence of only mild symptoms in patients who could tolerate a liquid diet, clinical evidence of perforation or peritonitis, evidence of multiple small-bowel obstructions because of peritoneal seeding as well as diabetes or other diseases that affect gastric motility and use of promotility agents.
safety and efficacy of activated recombinant human factor vii in patients undergoing orthotopic liver transplantation

Conditions: Acquired Bleeding Disorder; Bleeding During/Following Surgery

Summary: this trial is conducted in europe, north america and oceania. the aim of this trial is to evaluate the haemostatic efficacy of activated recombinant human factor vii in subjects undergoing orthotopic liver transplantation surgery.


Eligibility criteria:
inclusion criteria: * scheduled to undergo orthotopic liver transplantation * liver disease classified as child-turcotte (pughs modification) score b or c exclusion criteria: * previous liver transplantation * scheduled multi-organ transplantation * scheduled for living related donor transplantation * present renal insufficiency requiring dialysis * pregnancy
liver fibrosis in alpha-1 antitrypsin deficiency (liver aatd)

Conditions: Liver Fibrosis; Alpha-1 Antitrypsin Deficiency; AAT Deficiency; AATD

Summary: we hypothesize that individuals with alpha-1 antitrypsin (aat) deficiency have ongoing liver injury which is not detected by the usual blood tests used to look at liver function. this ongoing liver injury leads to cirrhosis in a significant number of adults with aat deficiency.

our overarching hypothesis is that liver disease in adults with aat deficiency is the result of the accumulation of the abnormally folded protein within the endoplasmic reticulum of the hepatocyte. in some individuals, the intrinsic cellular mechanisms of the hepatocyte are sufficient to clear adequate amounts of the abnormally folded protein such that liver disease does not occur. in aat deficient individuals who develop liver disease, environmental and other genetic factors stress the hepatocyte, and the normal cellular mechanisms that maintain homeostasis are disrupted, leading to liver disease. for this proposal, our hypothesis is that the prevalence of liver disease in adults with aat is higher than previously reported because liver injury and fibrosis is not accurately detected by available routine liver testing. testing this hypothesis will require an initial evaluation for liver disease with liver function testing and imaging, and then histologic confirmation by liver biopsy.

Eligibility criteria:
inclusion criteria: * alpha-1 antitrypsin deficiency confirmed to be pi\*zz by both genotype or another identified rare allele; * age range from 18-70; * willingness to consent to liver biopsy; * ability to travel to uf as necessary by protocol; and * platelet count greater than or equal to 50,000/mm3 and an inr less than or equal to 1.5. exclusion criteria: * hemophilia, anticoagulant therapy that cannot be interrupted briefly, malignancy, or any other condition that would compromise the safety of a liver biopsy; * any known pre-existing medical condition that might interfere with the patient's participation in and completion of the study or any condition, which in the opinion of the investigator would make the patient unsuitable for enrollment; * active substance abuse including, but not limited to, alcohol, intravenous or, inhaled drugs; * history of adverse reactions or allergy to the local anesthetic, sedative, or pre-medication used for the percutaneous liver biopsy; * poor venous access making the subject unable to complete the required laboratory testing schedule; and * females who are pregnant or lactating at time of enrollment. should a female subject become pregnant during the follow up period after the initial liver biopsy, continued participation would be allowed if the following conditions are met: the subject desires to continue; a discussion of risk and benefits of participation between the principal investigator and the subject has occurred; and no liver biopsy would be performed in the follow up period.

Keywords: liver fibrosis alpha-1 aat aatd
umbilical cord serum eye drops

Conditions: Recurrent Corneal Erosion

Summary: in the present study, the investigators investigated the efficacy of umbilical cord serum eye drops for the treatment of patients with recurrent corneal erosions. group a were treated with 20% umbilical cord serum eye drops 3 to 4 times a day in addition to artificial tears, and group b were treated with artificial tears only. ophthalmic examinations including visual acuity measurement and slit lamp biomicroscopy were performed before and every month after treatment. recurrence was defined as the presence of clinical symptoms accompanied by epithelial defects in the cornea.


Eligibility criteria:
inclusion criteria: * patients with recurrent corneal erosions exclusion criteria: * none

Keywords: umbilical cord serum recurrent corneal erosion