Kornimate/medical-research-clean huggingface dataset:
comparative study between different mobilization techniques for patients with chronic tennis elbow

Conditions: Tennis Elbow

Summary: background: tennis elbow is a common musculoskeletal disorder affecting the functional activities of daily living through common extensor tendinopathy. there is a limited knowledge about neural restriction as a source of movement limitation in patients with tennis other than enriched joint mobilization techniques knowledge. objectives: this study will be designed to determine the efficacy of adding different mobilization techniques along with eccentric exercises on elbow pain intensity, functional disability, hand grip strength and pain pressure in patients with chronic tennis elbow. methods: forty five patients with lateral epicondylitis with their ages ranged from 18 and 45 more than six weeks will be randomly assigned into three groups. group a will receive maitland joint mobilization techniques. patients in group b will receive mulligan mobilization techniques while patient in group c will receive radial nerve mobilization.. both groups will receive eccentric exercises for wrist extensors . patients will be treated three session per week for four week and they will be evaluated pre and post treatment for pain severity using by visual analogue scale, level of functionality by dash questionnaire, hand grip strength by hand held dynamometer and pressure pain threshold(ppt) by pressure algometer. results: all the outcome variables will be assessed at baseline and 4weeks following the treatment period.


Eligibility criteria:
inclusion criteria: * this study will include individuals between the ages of 18 and 45 who have been diagnosed with lateral epicondylitis based on positive results from the mill's and cozen's tests. the participants must also have complaints of local tenderness at the elbow that lasts longer than six weeks. additionally, to complete the assessment and get treatment, the participants' elbow must have a full extension range of motion exclusion criteria: * individuals diagnosed with cervical radiculopathy, upper thoracic outlet syndrome, rheumatoid arthritis, myositis ossificans, carpal tunnel syndrome, recent upper limb trauma, elbow immobilization, steroid injection administration within the previous six months, and any history of physical therapy administered within the previous six months were excluded from the study. furthermore, participation will not be permitted for anyone who has previously experienced discomfort because of their profession

Keywords: tennis elbow, grip strength, pain pressure threshold , nerve mobilization , maitland mobilization, mulligan mobilization
outcomes of purpura fulminans in adults - the hopeful study

Conditions: Purpura Fulminans

Summary: purpura fulminans (pf) is a rare life-threatening infectious disease characterized by the association of a sudden and extensive purpura together with acute circulatory failure. the mortality of pf has been reported to be as high as 50% in previous adult series. additionally, patients surviving to the early phase of pf are exposed to a high risk of limb amputation. the hopeful study aims at assessing the short and long term outcomes of adult patients admitted in the intensive care unit for a purpura fulminans.

purpura fulminans (pf) is a rare life-threatening infectious disease characterized by the association of a sudden and extensive purpura together with acute circulatory failure. neisseria meningitidis and streptococcus pneumoniae are the most frequently involved microorganisms but other species (e.g., staphylococcus aureus, streptococcus pyogenes, haemophilus influenzae...) have also been reported. despite prompt antibiotics administration and intensive care management, the mortality of pf has been reported to be as high as 50% in previous adult series. additionally, patients surviving to the early phase of pf are exposed to a high risk of serious sequelae related to extensive skin necrosis and acral symmetrical gangrene, which typically requires limb amputations, a potential source of severe handicap in these previously young and healthy patients. although the clinical features and outcomes of pf have been well studied in the pediatric setting, the amount of available data for adult pf are scarce, often outdated and mainly limited to patients with meningococcal infections. the current study aims at assessing the short and long-term outcomes of adult patients admitted in the intensive care unit for a purpura fulminans. a large multicenter retrospective cohort will be built in order to assess hospital outcomes (i.e., mortality and amputations). long-term outcomes, including health-related quality variables, will be prospectively assessed among survivors and compared to septic controls (i.e., patients having septic shock non-related to purpura fulminans).

Eligibility criteria:
inclusion criteria: * patients admitted in the intensive care unit between 2010 and 2016 for an infectious purpura fulminans and discharged alive exclusion criteria: * age \< 18 years * non infectious purpura * infective endocarditis

Keywords: health-related quality of life
transcranial magnetic stimulation on dorsomedial prefrontal cortex in borderline personality disorder

Conditions: Borderline Personality Disorder

Summary: this study evaluates the effect of 5hz repetitive transcranial magnetic stimulation (rtms) on dorsomedial prefrontal cortex on borderline personality disorder (bpd).

borderline personality disorder (bpd) is a mental illness with a high worldwide prevalence and economic costs, and is characterized with impulsiveness, both interpersonal relationships and emotional disturbance. symptoms are related to hypofunction of frontal areas like dorsomedial prefrontal cortex (dmpfc). psychotherapy is the base treatment in this disease, but economic costs and long-time therapy have made difficult the attachment. repetitive transcranial magnetic stimulation(rtms), authorized by food and drug administration (fda) on major depressive disorder (mdd) treatment has proven good results in previous works in bpd clinical characteristics on both dorsolateral prefrontal cortex (dlpfc) and enhancement in depressive symptoms stimulating dmpfc in high frequency. however, there are no current research that have addressed the use of low-frequency on this anatomical area.

Eligibility criteria:
inclusion criteria: * 18-45 years old. * meet dsm 5 (diagnostic and statistical manual, 5th edition) diagnostic criteria for borderline personality disorder. * score of \>7 in the diagnostic interview for borderline (revised version, dib-r) * all patients must have follow-up psychotherapy of at least one month. * no changes on pharmacological treatment within the last month. * patients must provide their oral and written informed consent. exclusion criteria: * subjects with history of traumatic brain injury with loss of consciousness. * subjects with intracranial metallic objects or metal plates in the skull. * subjects diagnosed with uncontrolled chronic (for example: hypertension, diabetes) or neurological diseases. * comorbidity with other mental illness. (except depressive symptoms and anxiety disorders). * presence of psychotic symptoms. * alterations in the electroencephalogram (epileptiform activity). * self injury or suicidal attempts in less than 2 weeks (depends on the severity and deepness).

Keywords: borderline personality disorder personality disorders
different intra-abdominal pressures and optic nerve size

Conditions: Major Surgery; Intraabdominal Hypertension; Optic Nerve Congestion

Summary: in intensive care patients, high intraabdominal pressure is frequently encountered. intra-abdominal pressure is often measured as high, especially after major abdominal surgery procedures. in recent years, various studies have reported that the increase in optic nerve diameter measured by ultrasound correlates with the level of intracranial pressure. optic nerve diameter measurement with ultrasound is a non-invasive procedure. intra-abdominal pressure measurements are also routinely performed in intensive care patients. in the measurement of abdominal pressure, the bladder catheter, which is already available in every patient who comes to intensive care, is used. in this study, the intra-abdominal pressure values present in the file of each patient undergoing major abdominal surgery who were taken to intensive care unit will be taken. orbital usg will be performed on the 6th, 12th and 24th hours on admission to the intensive care unit to measure the diameter of the optic nerve, and the relationship between the intra-abdominal pressure value and optic nerve diameters will be investigated.

in intensive care patients, high intraabdominal pressure is frequently encountered. intra-abdominal pressure is often measured as high, especially after major abdominal surgery procedures. this situation creates ischemia in the abdominal organs in the patient, decreases venous return as a result of inferior vena cava compression and leads to a decrease in cardiac output. in addition, intracranial pressure frequently increases as a result of the venous circulation being affected. in recent years, various studies have reported that the increase in optic nerve diameter measured by ultrasound correlates with the level of intracranial pressure. optic nerve diameter measurement with ultrasound is a non-invasive procedure. intra-abdominal pressure measurements are also routinely performed in intensive care patients. in the measurement of abdominal pressure, the bladder catheter, which is already available in every patient who comes to intensive care, is used. in this study, the intra-abdominal pressure values present in the file of each patient undergoing major abdominal surgery who were taken to intensive care unit will be taken. orbital usg will be performed on the 6th, 12th and 24th hours on admission to the intensive care unit to measure the diameter of the optic nerve, and the relationship between the intra-abdominal pressure value and optic nerve diameters will be investigated.

Eligibility criteria:
inclusion criteria: having had major abdominal surgery exclusion criteria: 1. pregnant patients 2. patients whose bladder catheter cannot be inserted 3. patients with diagnosed or suspected brain death
postoperatory recovery in thoracic surgical procedure, fast-track protocol vs. conventional care

Conditions: Thoracic Surgery

Summary: the aim of this study was to compare the functional capacity of exercise by six-minute walk test before and after thoracic surgical procedure in subjects who have undergone the fast-track protocol with those who were under conventional care. researchers want to find out if fast-track is a strategy to enhance functional capacity after thoracic surgery.

fast track programs represents a new approach to the management of patients undergoing surgery. it is perioperative care pathway designed to achieve early recovery and helps to minimize postoperative morbidity and mortality. these multimodal approaches focuses on enhancing recovery and reducing of surgical stress by minimal invasive surgery, optimized pain relief, early nutrition and ambulation. in postoperative, the bed rest leads to the increase in muscle loss and weakness, impairs pulmonary function, predisposes to venous stasis and thromboembolism, increases infection complications and reduces functional capacity. however, information on the results of fast-track protocols in functional capacity of exercise during hospital stay is sparse. the six-minute walk test is use to measure of functional capacity of exercise in different populations and to detect changes after interventions. the distances traveled in two six-minute walk test (preoperative and postoperative) will be compared between the two groups (fast-track and conventional). in this trial the investigators will consider fast-track protocol to be feasible to enhance functional capacity of exercise after thoracic surgery.

Eligibility criteria:
inclusion criteria: * patients who are scheduled to undergo a thoracic surgical procedure * sign the informed consent form * independent ambulation * ability to understand and follow instructions exclusion criteria: * contraindications for epidural catheter placement * refusal to do physical exercises on postoperative

Keywords: postoperative care exercise test early ambulation fast-track
patients returning to work after acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: the literature is quite rich concerning the factors which influence the return to work after acute coronary syndrome. they can be divided into three categories: factors linked to the patient, those linked to the workstation and factors linked to an external intervention. a study published in 1992 evaluated a set of predictive factors for recovery one year after acute coronary syndrome and showed that the proportion of clinical factors accounted for 20%, functional factors for 27% but above all socio-economic factors for 45. %. on the other hand, there are only a few studies that are interested in the return to work after acute coronary syndrome according to the management in occupational medicine, and in particular the realization or not of a pre-return visit. the results of a survey published in 2016 show that the recommendations made during the return visit were significantly different depending on whether or not there was a pre-return visit and concerned all types of pathology. in view of all of these elements, it seems important to the investigators to study the expected benefit of an early orientation towards occupational medicine via the pre-return visit, and to study the factors delaying or favoring the return to work. .


Eligibility criteria:
inclusion criteria: * age ≥18 years old * in professional activity during acute coronary syndrome (employee, civil servant, self-employed or looking for a job) * -mastering the french language (knowing how to read and write french) * agreeing to participate in the study and not having expressed his opposition to the reuse of his data for the purposes of this research exclusion criteria: * subject having expressed opposition to participating in the study * inability to provide informed information about the subject (subject in an emergency situation, difficulty in understanding the subject, etc.) * subject under safeguard of justice * subject under guardianship or guardianship

Keywords: acute coronary syndrome acs return to work occupational health cardiology intensive-care unit
bioinformation therapy for gastric cancer

Conditions: Advanced Gastric Cancer

Summary: the aim of this study is the synergistic effect of cancer ablation and life information rehabilitation therapy on unresectable gastric cancer.

by enrolling patients with unresectable gastric cancer adapted to enrolled criteria,this study will document for the first time the synergistic effect of cancer according to local relief degree,progress free survival(pfs)and overall survival(os).

Eligibility criteria:
inclusion criteria: * all standard therapies have failed according to nccn guidelines or the patient refuses standard therapies * body tumor 1-6, with at least one tumor length \> 2 cm * kps ≥ 70, lifespan：3-6 months * platelet count ≥ 80×109/l，white blood cell count ≥ 3×109/l, neutrophil count ≥ 2×109/l, hemoglobin ≥ 80 g/l exclusion criteria: * patients with cardiac pacemaker * patients with brain metastasis * patients with grade 3 hypertension or diabetic complication, severe cardiac and pulmonary dysfunction

Keywords: cancer ablation life information rehabilitation therapy
the role of hepcidin as a biomarker to predict successful renal transplantation

Conditions: End-stage Renal Disease

Summary: high hepcidin concentrations indicate that iron is blocked from secretion from the reservoir. hepcidin may be useful in prediction functional iron utilization in renal failure patients. hepcidin is also associated with chronic renal failure and residual renal function in dialysis patients. recent studies have shown that hepcidin is a potential marker of impaired renal function in a rat model of chronic nephropathy. the purpose of this study was to investigate the relationship between preoperative hepcidin levels and the incidence of success rate of kidney transplantation in patients with end-stage renal failure undergoing kidney transplantation surgery. the study is a prospective single-group observational study that analyzes hepcidin as a biomarker.

pod-1 : researchers will meet patients scheduled for surgery and explain the study. (enroll) the operation date : the patient will sign the consent form. researchers will collect the blood sample from the patient for testing hepcidin during the operation and record laboratory data performed before surgery pod 1: laboratory test discharge date : laboratory test 6 months after surgery ; researchers will determine the graft failure of the patient. \* laboratory test ; reticulocyte count, hb, plasma hepcidin, iron profiles (serum iron, serum ferritin, total iron-binding capacity, transferrin, transferrin saturation), coagulation profiles (pt, ptt), routine urinary analysis, and chemical profiles (aspartate aminotransferase (ast)/alanine aminotransaminase (alt), serum creatinine, electrolytes, c-reactive protein (crp), estimated glomerular filtration rate (gfr)), esr, cystatin c, ngal, pro bnp, troponin t and urinary analysis

Eligibility criteria:
inclusion criteria: 1. the patients who plan to undergo kidney transplantation 2. asa iii-iv 3. adult over 19 years old exclusion criteria: 1. emergent case 2. heart disease 3. arrhythmia 4. bmi \>30kg/m2 5. allergy to some drugs 6. if other co-operation is planned 7. foreigner 8. illiteracy
ex-vivo modulatory effect of biological drugs for inflammatory bowel disease on the mucosa and on peripheral blood mononuclear cells

Conditions: Inflammatory Bowel Disease

Summary: to characterize circulating dc subsets from healthy controls and ibd patients and to assess, following an ex vivo challenge, the effect of anti-tnf (infliximab, adalimumab and golimumab), anti-p40 -il-12/il-23- (ustekinumab) and anti-α4β7 (vedolizumab) immunomodulators on both the gi production of soluble immune mediators and the mucosal capacity to alter the recruitment capacity of circulating dc subsets. it is expected that such approach will provide further information on the action mechanisms of such therapies on ibd patients, allowing a better understanding of the pathophysiology of this disease and the identification of tissue-specific therapeutic targets, thus avoiding collateral problems associated with systemic immunomodulation.


Eligibility criteria:
inclusion criteria: patients with active ibd, and endoscopic and histological diagnosis of cd or uc that attend a colonoscopy with sedation performed by medical criteria. patients without an ibd diagnosis, or other types of inflammatory, allergic, malignant or autoimmune diseases, prior to their inclusion in this project. all patients will attend a colonoscopy with sedation at medical judgment with biopsy indication for histopathological study as in cases of diarrhea but also due to changes in the bowel transit, rectal bleeding or screening for gastrointestinal diseases. patients will be paired in age and gender with the ibd groups. all patients will have no signs of macroscopic or microscopic inflammation hence excluding the presence of microscopic colitis. exclusion criteria: 1. age less than 18 years 2. chronic disease or any other advanced clinically significant pathology, uncontrolled by investigator judgment. 3. should be with medication, this will be unchanged in the 3 months prior to colonoscopy. 4. alcohol or drugs. 5. pregnancy or lactation 6. do not sign the informed consent form (see "ethical issues") in any case no colonoscopies exclusively targeted for sampling for this project will be made
hemodynamics during induction of general anesthesia with medium or low remifentanil doses.

Conditions: Hemodynamic Instability; Anesthesia, General; Anesthesia, Intravenous

Summary: in this trial the investigators want to examine if there is any difference in hemodynamic stability during induction when comparing two low and a medium remifentanil dose and keeping propofol induction dose at about 2.0 mg/kg.

typically, one or more adjuvant medications is administered during induction of general anesthesia. when anesthetic drugs are combined, the hypnotic effects are often synergistic. propofol is associated with hypotension and bradycardia and used together with remifentanil or sedative agents it may give synergistic or additive sedative and hemodynamic effects. remifentanil is infused at 0.05-0.3 microg/kg/min during induction of anesthesia. some use a loading dose of 0.5-1.0 microg/kg before starting the continuous infusion. the onset of action of remifentanil is within one to two minutes and it reaches rapidly a steady state effect site concentration after a bolus dose. kazmaier (2000) showed that a high-dose remifentanil anesthesia (2 microg/kg/min) reduced cardiac index (-25%), stroke volume (-14%) and mean arterial blood pressure (-39%) in a similar manner as propofol/remifentanil (propofol target 2 microg/ml and remifentanil 0.5 microg/kg/min), but systemic vascular resistance index decreased (-14%) in propofol/remifentanil combination. fairfield et al have earlier (1991) showed that propofol 2.5 mg/kg induction without opioid reduces cardiac output (-15%) stroke volume (-5 %), mean arterial pressure (-33%) and systemic vascular resistance (-11%) and a slight reduction i heart rate. guarracino (2003) suggests the reduction in cardiac index during induction with propofol/remifentanil with a low propofol target (1.2 microg/ml) may be due to decreased heart rate. zaballos (2009) have shown that remifentanil depresses sinus node and atrioventricular (av) -nodal function in comparison with propofol alone in a closed chest porcine model. hayashi (2016) states that even in a low remifentanil effect site concentration (3.5 nanog/ml) it may reduce heart rate significantly when combined with propofol bolus 30-50 mg.

Eligibility criteria:
inclusion criteria: * gynecological procedure * age 18-50 years * general anesthesia planned * systolic blood pressure \< 150 mmhg, hr \< 100 beats/min exclusion criteria: * pre-existing hypertension * diabetes * ischemic heart disease or cerebrovascular disease * heart valve disease * verified cardiac arrhythmia other than extrasystoles * verified anaemia with hemoglobin level below 9.0 gr/dl. * kidney or hepatic disease * hypersensitivity for propofol, soya, eggs or peanuts * pregnancy * poor health state * illicit substance use * bmi \ 35 kg/m2

Keywords: cardiac output (co) systolic blood pressure (sbp) systemic vascular resistance (svr) heart rate (hr) stroke volume (sv) lithium dilutional cardiac output (lidco) minimal invasive hemodynamic monitor remifentanil
mindfulness training and group counseling among prediabetes and diabetes patients

Conditions: Stress; Diabetes; Pre-Diabetes; Health Behavior; Quality of Life

Summary: examining a number of health outcomes in those with diabetes and prediabetes before and after a group-based mindfulness intervention.

this is a pilot study to examine the feasibility of integrating a mindfulness-based stress reduction (mbsr) intervention in addition to an existing group-based, peer supported clinical care model (jump) among patients with pre-diabetes or diabetes using a mixed-method design.

Eligibility criteria:
inclusion criteria: * 18 years or older * english speaking * having a diagnosis of diabetes or prediabetes * participation in a previous group-based clinical care model-jump (as in "jumping into diabetes control") exclusion criteria: * under 18 years old * non-english speaking * not having a diagnosis of diabetes or prediabetes * no participation in jump model

Keywords: stress mindfulness diabetes pre-diabetes