Kornimate/medical-research-clean huggingface dataset:
the effect of carboxymetyl starch (oozfix) on preventing postoperative complication after gastrectomy

Conditions: Stomach Neoplasm

Summary: although the technique of radical gastrectomy had been advanced, postoperative complication can occur in 13\~25% of patient after radical gastrectomy. pancreatic fistula and postoperative bleeding was reported as 2\~30% and 1\~2%, respectively. these complications often result fatal clinical course, so localized fibrin agent has been widely used at postoperative surgical bed after radical gastrectomy. recently, natural origin polysaccharide-based carboxymetyl starch was approved as localized coagulative, no well-designed report was adressed in gastric cancer surgery field. this agent can formate physical barrier after application, thus can prevent microbleeding or pancreatic fistula after gastrectomy. this study is single-center, non-inferiority, open-label randomized trial that evaluates the effect of carboxymetyl starch (oozfix) on preventing postoperative complication after gastrectomy.

although the technique of radical gastrectomy had been advanced, postoperative complication can occur in 13\~25% of patient after radical gastrectomy. pancreatic fistula and postoperative bleeding was reported as 2\~30% and 1\~2%, respectively. these complications often result fatal clinical course, so localized fibrin agent has been widely used at postoperative surgical bed after radical gastrectomy. recently, natural origin polysaccharide-based carboxymetyl starch was approved as localized coagulative, no well-designed report was adressed in gastric cancer surgery field. this agent can formate physical barrier after application, thus can prevent microbleeding or pancreatic fistula after gastrectomy. this study is single-center, non-inferiority, open-label randomized trial that evaluates the effect of carboxymetyl starch (oozfix) on preventing postoperative complication after gastrectomy.

Eligibility criteria:
inclusion criteria: 1. gastric adenocarcinoma patient who underwent radical gastrectomy at bucheon st. mary's hospital 2. patient's age is above 19 and less than 80 3. ecog performance score : 0\~2 exclusion criteria: 1. patient who underwent emergent gastrectomy 2. patient who requires palliative gastrectomy due to advanced or metastatic carcinoma 3. patient who requires operation due to other malignancy other than adenocrcinoma 4. patient who underwent emergent gastrectomy or pancreatectomy before this study 5. patient who underwent chemoradiation 6. patient who took anticoagulants or with coagulopathy
a pilot study evaluation of the efficacy of sonovue to detect and characterise breast lesions

Conditions: Breast Tumors

Summary: ultrasound is a well-established imaging modality for the evaluation of breast disease. the investigators' objective is to characterise the properties of an intravascular ultrasonographic contrast agent sonovue (sulphur hexafluoride microbubbles) to improve the diagnostic value of the ultrasound examination in patients with different breast lesions. the final purpose of this ultrasonography is to allow the early detection of tumors and to improve the differentiation between benign and malignant lesions. sonovue® (sulphur hexafluoride microbubbles) is a microbubbles preparation that is stable, resistant to pressure, and specifically designed to be used as a contrast agent for ultrasound imaging. contrast-enhanced ultrasound could provide a non-invasive technique to evaluate the morphology of breast tumour vascularity.

the main objective of the study is to evaluate the efficacy of sonovue® to detect breast lesions and define specific microcirculation patterns in patients with four different type of breast lesions (enlarging fibroadenoma, suspect malignant nodules, microcalcification and large malignant nodules) in comparison with pathological specimens in terms of histology diagnosis and microvessel density evaluation.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * woman presenting with: enlarging fibroadenoma (less than 2 cm in diameter or woman over 40 years old with fibroadenoma less than 2 cm in diameter) or suspect malignant nodule (less than 2 cm in diameter) or a cluster of microcalcification or a malignant nodule (size greater than 3 cm) diagnosed with mammography and/or mri and/or united states (us) examination performed within 1 month before the study. * woman scheduled for biopsy or surgery within 1 month from the examination. exclusion criteria: * patients who have already performed a biopsy on the lesion during investigation * any contraindication to perform a contrast-enhanced mri examination for the patients presenting with a malignant nodule (size greater than 3 cm) * patients previously entered in this study or having received an investigational drug within 30 days prior to admission to this study * patients with any medical condition or other circumstances which would significantly decrease the chances of obtaining reliable data or of achieving the study objectives (drug dependence, psychiatric disorders, dementia or other reasons) * pregnant or nursing female * patient known to have a coronary syndrome * unstable angina and myocardial infarction * acute cardiac failure, class iii/iv cardiac failure * severe rhythm disorders * acute endocarditis * prosthetic valves

Keywords: contrast-enhanced ultrasound sonography ultrasound contrast agents, microbubbles breast tumors
a trial of carboxypeptidase-g2 (cpdg2) and thymidine for the management of patients with methotrexate toxicity and renal dysfunction

Conditions: Kidney Diseases

Summary: high dose methotrexate with leucovorin rescue has demonstrated activity in numerous malignancies. although high dose methotrexate is generally well tolerated, unpredictable life-threatening toxicity can occur. for patients who have markedly delayed clearance of methotrexate secondary to renal dysfunction, therapeutic options are few and are of limited efficacy. carboxypeptidase-g2 inactivates methotrexate by hydrolyzing its c-terminal glutamate residue. carboxypeptidase-g2 could be used to rescue patients with renal dysfunction and delayed methotrexate excretion, as it provides an alternative to renal clearance as a route of elimination.

high dose methotrexate with leucovorin rescue has demonstrated activity in numerous malignancies. although high dose methotrexate is generally well tolerated, unpredictable life-threatening toxicity can occur. for patients who have markedly delayed clearance of methotrexate secondary to renal dysfunction, therapeutic options are few and are of limited efficacy. carboxypeptidase-g2 inactivates methotrexate by hydrolyzing its c-terminal glutamate residue. carboxypeptidase-g2 could be used to rescue patients with renal dysfunction and delayed methotrexate excretion, as it provides an alternative to renal clearance as a route of elimination.

Eligibility criteria:
patients of any age at risk for life-threatening toxicity following mtx administration secondary to delayed drug excretion as defined by: plasma mtx concentration at least 10 micromoles/liter more than 42 hours after the start of the mtx infusion; or creatinine at least 1.5 times the upper limit of normal or creatinine clearance less than 60 ml/sqm/min and delayed mtx excretion documented by plasma mtx concentration measurements (at least 2 standard deviations above the mean) at least 12 hours following mtx administration.

Keywords: antibody dampa enzyme kidney pharmacokinetics thymidine toxicity
a study of ixekizumab (ly2439821) in tnf inhibitor experienced participants with radiographic axial spondyloarthritis

Conditions: Spondyloarthritis

Summary: the main purpose of this study is to evaluate the efficacy and safety of ixekizumab in tumor necrosis factor (tnf) inhibitor-experienced participants with radiographic axial spondyloarthritis (rad-axspa).


Eligibility criteria:
inclusion criteria: * are ambulatory. * have an established diagnosis of radiographic axial spondyloarthritis (rad-xspa) with sacroiliitis defined radiographically according to the modified new york criteria. * participants have a history of back pain ≥3 months with age at onset \<45 years. * have had prior treatment with at least 1 and not more than 2 tnf inhibitors. * must have had an inadequate response to 2 or more nsaids at the therapeutic dose range for a total duration of at least 4 weeks or have a history of intolerance to nsaids. * have a history of prior therapy for axspa for at least 12 weeks prior to screening. exclusion criteria: * have total ankylosis of the spine. * have never taken a tnf inhibitor medication or have taken more than 2. * have recently received a live vaccine within 12 weeks or have had a vaccination with bacillus calmette-guerin (bcg) within the past year. * have an ongoing or serious infection within the last 12 weeks or evidence of active tuberculosis. * have a compromised immune system. * have any other serious and/or uncontrolled diseases. * have either a current diagnosis or a recent history of malignant disease. * have had major surgery within 8 weeks of baseline, or will require surgery during the study. * are pregnant or breastfeeding.

Keywords: ankylosing spondylitis
antifungal activity of loceryl nail lacquer in combination with a cosmetic varnish

Conditions: Foot Dermatoses

Summary: the main objective is to compare efficacy, in terms of antifungal activity of loceryl nail lacquer associated with a cosmetic varnish and loceryl nail lacquer alone, in the treatment of mild to moderate toenail distal subungual onychomycosis. the second objective of this study will be photographic follow-up of clinical improvement and cure after the initial treatment period of 12 weeks, for 15 additional months.

study center: a total of 50 subjects were to be included in 1 site in iceland. methodology: * group loceryl nail lacquer+ cosmetic varnish: * loceryl nail lacquer to be applied once weekly for 12 weeks on all affected toenails, * cosmetic varnish to be applied once weekly for 12 weeks on all affected toenails and/or all toenails. * group loceryl nail lacquer alone: - loceryl nail lacquer to be applied once weekly for 12 weeks on all affected toenails. * all eligible subejct with no clinical sign of clinical aggravation of onychomycosis at week 12, could continue to apply loceryl nail lacquer alone, once a week for 15 additional months (or less in case of complete cure).

Eligibility criteria:
inclusion criteria: * subjects with a mild to moderate distal subungual onychomycosis (dso) on at least 1 great toenail chosen as a target nail * subjects must have maximum of 50% of nail distal edge involved * subjects with positive mycological results (direct microscopy and culture) of the target nail for dermatophytes or yeast (including candida) at screening exclusion criteria: * subjects with clinically important abnormal physical findings at the screening/baseline visit * subjects with lichen planus, eczema, psoriasis, or other abnormalities of the nail unit * subjects with known immunodeficiencies, radiation therapy, immune suppressive drugs

Keywords: onychomycosis antifungal
web-based education module for pain management

Conditions: Bone Fractures

Summary: this study's objectives are as follows: 1. to evaluate the utility of a website to provide information and guidance about pain management in children 2. to educate parents about the pathophysiology of pain, proper use of analgesic medications and signs of pain in children 3. to reduce the functional impact of pain in children following treatment for fracture 4. to endow parents with confidence to manage their child's pain at home 5. to dispel misconceptions about the use and safety of analgesics in children 6. to increase awareness of complications of fractures such as compartment syndrome

this study will compare the effectiveness of three mediums of parental education among parents of children treated for non-operative fractures in the emergency department (ed): 1) a novel website entitled, "online user-centered home pain management for fractures" (ouch pmf) 2) an online educational video (ov) and 3) standard discharge instructions (soc). the investigators primary goal is to see which modality results in a greater improvement in scores on a on a knowledge questionnaire. the investigators secondary goals are to see which modality results in better parental satisfaction, confidence in managing pain, and lower impact of injury on the child and family. as participants will receive the standard-of-care that includes a pamphlet on how to take care of the cast. during their stay in the ed, participants will be randomly assigned to one of the three aforementioned groups. participants will then be given the pre-intervention knowledge questionnaire, followed by the intervention and then the post-intervention knowledge questionnaire, prior to being discharged. at 120 hours post-discharge, participants will be asked to access an online survey to obtain information about the functional impact of the injury on their child. the investigators goal is to compare online and video education tools in their ability to improve parental knowledge, confidence, and satisfaction regarding the treatment of fracture pain.

Eligibility criteria:
inclusion criteria: * all caregivers who are in attendance with their child (any age) for a primary complaint of a non-operative fracture managed by the paediatric emergency physician and will be the primary caregiver for the child at home. exclusion criteria: * poor parental english fluency * lack of a home computer with internet access * child with a history of renal disease, liver disease, bleeding diathesis, chronic pain issues, or pregnancy.
neural mobilization versus pnf hold relax technique on lower extremity in hemiplegic stroke

Conditions: Hemiplegic Stroke

Summary: several studies about the effects of nerve mobilizations and stretching exercises have been conducted. this study will contribute to describing the long term effects of these techniques on gait, motor function and quality of life in hemiplegic stroke patients and compare the effectiveness of both techniques.

several studies about the effects of nerve mobilizations and stretching exercises have been conducted. evidence regarding the comparison of these two techniques is sparse and is based on different clinical experiences and a less number of studies with limited methodological design. there has been no work regarding the long term effects of these two techniques in improving lower limb motor function in hemiplegic stroke patients. this study will contribute to describing the long term effects of these techniques on gait, motor function and quality of life in hemiplegic stroke patients and compare the effectiveness of both techniques. a total of 54 patients diagnosed with hemiplegic stroke will be selected for the collection of data according to the inclusion criteria. patients will be divided into two groups, group a and group b. group a will receive sciatic nerve mobilization (sliding technique) and group b will receive proprioceptive neuromuscular mobilization hold relax technique 3 days a week for 30 mins per day for 6 weeks. sciatic nerve mobilizations (sliding technique) will be performed for a duration of 1 minute each for 6 such sets with 60 seconds rest period followed by every set. the hold relax technique of hamstring will be performed with each hold period lasting for 10 seconds followed by a relaxation phase of 10-15 seconds for 10 repetitions. data will be collected at baseline, after 3weeks and at 6 weeks after intervention from both groups. gait will be measured using tug (timed up and go), quality of life will be measured using the urdu version of ss-qol(stroke-specific quality of life)and lower limb motor function will be measured using fugl meyer scale(lower extremity)

Eligibility criteria:
inclusion criteria: * patients with subacute to chronic (3-12months) hemiplegic stroke. * both genders. * age between 20 and 70 years. * patients classified as grade 2 and 3 as per the modified rankin scale. * patients with or without assistive devices. exclusion criteria: * patients having cardiac disorders, rheumatic and orthopedic diseases that would impede the performance of the technique. * patients who have undergone some surgery recently. * patients having cognitive impairments. * contractures of the lower limb joints. * patients having associated neurological pathologies.

Keywords: neural mobilization pnf hold relax stroke
cyrolipolysis vs cyrolipolysis and subcision for cellulite

Conditions: Cellulite

Summary: this is a prospective randomized controlled study comparing the efficacy of cryolipolysis versus a combination of cryolipolysis and surgical subcision for the treatment of cellulite. the treatment sites are both outer thighs. one outer thigh will be randomized to receive one treatment of cryolipolysis, while the contralateral thigh will be assigned to receive the combination cryolipolysis plus surgical subcision. a live rating by a blinded dermatologist will evaluate the treatment and control areas using a cellulite severity scale at week 0 (before treatment) and at the 3-month follow up visit.


Eligibility criteria:
inclusion criteria: 1. healthy female subjects 18-65 years of age with at least a 5 on the css scale on both outer thighs. 2. all subjects must have the affected areas that show the mattress phenomenon spontaneously when standing or while both lying and standing (stage 2 or 3 of nurnberger-muller grading scale of cellulite7). 3. subjects who are willing and have the ability to understand and provide informed consent for participation in the study and are able to communicate with the investigator. exclusion criteria: 1. subjects who are pregnant or lactating. 2. subjects who are unable to understand the protocol or to give informed consent. 3. subjects currently under treatment with an antiplatelet or anticoagulant for any medical problem or patients who have coagulation disorder. 4. subjects who have a known history of cold-induced disease such as cryoglobulinemia, paroxysmal cold hemoglobulinuria, cold urticaria. 5. subjects who have active skin disease or skin infection in the treatment area. 6. subjects who are allergic to lidocaine or prilocaine. 7. subjects who are allergic to both cephalexin (or penicillin) and levofloxacin (or another quinolone antibiotic). 8. subjects who have history of abnormal scarring.
treatment of intraosseous periodontal defects with hyaluronic acid

Conditions: Periodontal Bone Loss; Periodontal Pocket

Summary: the aim of the present investigation will be evaluate the healing of periodontal intraosseous defects following minimally invasive non surgical debridement (minsd) and application of a hyaluronic acid-based gel, compared to minsd alone. a total of 22 patients will be enrolled, selected by inclusion and exclusion criteria and randomly divided in two groups: hyaluronic acid group (ha) and no-hyaluronic acid group (no-ha).

the objective of the study will be compare the healing of periodontal intraosseous defects following treatment with minimally invasive non surgical debridement (minsd) and application of hyaluronic acid (ha) compared to minsd alone. twenty-two patients with intraosseous periodontal defects will be randomly assigned to treatment with minsd and application of a hyaluronic acid-based gel (ha group) or minsd alone (no-ha group). primary outcome will be "probing depth" (pd), while the secondary outcomes will be "clinical attachment level" (cal) gain, "gingival recession" (gr) and "radiographic defect angle" (rda). after local anesthesia, in ha group minsd will be performed using an ultrasonic scaler with fine tips and micro-curette; then, a hyaluronic acid-based gel will be applied to the intraosseous periodontal pockets. in the no-ha group, only subgingival mechanical debridement (minsd) will be performed with an ultrasonic scaler with fine tips and micro-curette. finally, a polishing paste will be applied to the supra-gingival level in both groups using a rubber cup. patients of both groups will be recalled every month for professional oral hygiene and, after 6 months, all measurements will be repeated and the final evaluation will be carried out.

Eligibility criteria:
inclusion criteria: * patients diagnosed with periodontitis; * age ≥ 18 years old; * presence of at least 10 teeth per arch; * presence of at least two teeth with probing depth (pd) ≥ 5 mm per quadrant; * presence of at least one intraosseous pocket; * single-rooted and multi-rooted teeth. exclusion criteria: * patients with systemic diseases; * prolonged antibiotic or anti-inflammatory treatment within 4 weeks prior to periodontal therapy; * pregnant or lactating; * tobacco smokers (≥ 10 cigarettes per day); * multi-rooted teeth with furcation involvement; * third molars.

Keywords: hyaluronic acid periodontal therapy periodontal bone loss intraosseous bone defect
isokinetic testing protocol in elderly and young men

Conditions: Healthy

Summary: an age-related decrease in muscular strength may have a detrimental effect on muscle fatigue and recovery. to date, only one study has determined the effect of varied rest intervals (ri) between exercise sets in active younger and older women. they reported that active younger and older women require similar ri between sets to recovery full isokinetic knee extension peak torque (pt). however, we are unaware of any published studies comparing ri pt recovery between younger and older men. thus, the purpose of this study was to compare the effect of two different ri's between sets of isokinetic knee extension exercise on pt, and total work (tw) between untrained younger and older men.

18 young men (24.22 ± 2.58 yrs) and 20 older men (66.85 ± 4.02 yrs) performed 3 sets of 10 unilateral isokinetic knee extension repetitions at 60°/s. the rest intervals between sets were 1 and 2 minutes and were counterbalanced across 2 testing days, separated by a minimum of 48 hours. the work-to-rest ratio was 1:3 and 1:6. all subjects were not involved in exercise programs that included resistance exercises within the last 6 months. statistical evaluation of the data was performed using a 2x 2 x 3 mixed factor repeated measures anova \[age (younger and older) x rest interval (1 and 2 min) x set (1st, 2nd, and 3rd)\]. statistical significance was set at p \< 0.05 for all comparisons.

Eligibility criteria:
inclusion criteria: * less than 75 years * independent exclusion criteria: * history of cardiovascular disease * hypertension * orthopedic disease

Keywords: isokinetic fatigue strength older
is there a microbiome associated with poor growth in preterm infants?

Conditions: Growth Disorders; Growth Failure; Prematurity

Summary: this study evaluates the relationship between growth and stool microbiota in premature infants.

preterm infants often require increased caloric intake to maintain appropriate growth while in the neonatal intensive care unit (nicu). while some infants will have a clear source of need for greater calories, it is often not obvious why others require increased available calories to maintain appropriate growth. emerging evidence suggests that patterns of gut microbiota may play a role in infant and childhood growth. we hypothesize that differences in the microbial pattern in preterm infants is related to poor growth and need for increased caloric intake. this may ultimately represent a therapeutic target to improve the growth of preterm infants in the nicu. this study aims to describe the differences in microbiome which may vary with growth pattern.

Eligibility criteria:
inclusion criteria: all infants less than 28 weeks gestation who are admitted to the parkland hospital nicu. exclusion criteria: infants \>27 weeks gestation. infants with major congenital anomalies which may alter growth patterns.