Kornimate/medical-research-clean huggingface dataset:
return to sports after aclr

Conditions: Anterior Cruciate Ligament Injuries; Reconstruction

Summary: patients who were surgically treated with acl reconstruction at a single clinic between 2013 and 2018 will be approached by a questionnaire regarding their return to sport after surgery. questions will focus on the timepoint of the return, subsequent injuries, and the impact of the initial injury on the life of the patients. in addition, existing clinical data from the baseline visit and from the follow-up visits offered routinely to the patient will be used.


Eligibility criteria:
inclusion criteria: * age ≥18 * acl injury * surgically treated with acl reconstruction at the crossklinik or affiliated institutions between 1.1.2013 and 31.12.2018 exclusion criteria: * different treatment approach to the injury (e.g. conservative, stimulation of healing response, surgical treatment for re-rupture etc.).

Keywords: anterior cruciate ligament injuries return to sport
efficacy study of opc-34712 in adults with acute schizophrenia

Conditions: Acute Schizophrenia

Summary: the purpose of this study is to assess the efficacy, safety, and tolerability of fixed doses of opc-34712 versus placebo for the treatment of adult subjects with an acute relapse of schizophrenia.

schizophrenia is a severely debilitating mental illness that affects approximately 1% of the world population. hallucinations and delusions are the most striking characteristic positive symptoms of schizophrenia; however, more subtle negative symptoms (eg, social withdrawal and lack of emotion, energy, and motivation) may also be present. the first antipsychotics developed for the treatment of schizophrenia were effective against positive symptoms, but showed little efficacy for negative symptoms and were also associated with a high incidence of side effects. second generation antipsychotics, represent a significant advancement in the treatment of psychotic disorders because they are effective and at the same time exhibit fewer side effects than first generation antipsychotics. although generally safer than first generation antipsychotics, the second-generation antipsychotics are not devoid of undesirable side effects such as hyperprolactinemia and weight gain. in addition, the safety of these drugs vary considerably.

Eligibility criteria:
inclusion criteria: 1. male or female subjects between 18 and 65 years of age, with a diagnosis of schizophrenia, as defined by dsm-iv-tr criteria 2. subjects who have been recently hospitalized or who would benefit from hospitalization for an acute relapse of schizophrenia 3. subjects experiencing an acute exacerbation of psychotic symptoms 4. other protocol specific inclusion criteria may apply exclusion criteria: 1. females who are breast-feeding and/or who have a positive pregnancy test result prior to receiving study drug 2. subjects with a current dsm-iv-tr axis i diagnosis of: * schizoaffective disorder * mdd * bipolar disorder * delirium, dementia, amnestic or other cognitive disorder * borderline, paranoid, histrionic, schizotypal, schizoid or antisocial personality disorder 3. subjects presenting with a first episode of schizophrenia 4. other protocol specific exclusion criteria may apply
intravenous tranexamic acid during rhytidectomy

Conditions: Bleeding; Bruising Face; Swelling Lips & Face

Summary: this is a prospective, randomized, double-blind study investigating whether intravenous tranexamic acid has any effect on rhytidectomy surgery, or the subsequent postoperative sequelae. intraoperative bleeding and postoperative ecchymosis and edema are subjectively rated and complications are noted.

this is a prospective, randomized, double-blind pilot study investigating whether intravenous tranexamic acid has any effect on rhytidectomy surgery, or the subsequent postoperative sequelae. intraoperative bleeding is rated on a scale of mild, moderate, or severe and given a score of 1-3. postoperative ecchymosis and edema are subjectively rated by both patient and surgeon on postoperative days 1, 6, and 9 using a similar mild/moderate/severe scale and scored 1-3, respectively. any surgical or postoperative complications are noted. scores are aggregated for statistical analysis.

Eligibility criteria:
inclusion criteria: * undergoing rhytidectomy surgery at glasgold group plastic surgery exclusion criteria: * history of bleeding disorder, history of thromboembolic events, history of seizure, active use of oral contraceptive pills or hormone replacement therapy, participant preference

Keywords: tranexamic acid rhytidectomy facelift
efficacy and safety of the combination of ketoprofen and cyclobenzaprine in osteomuscular treatment

Conditions: Musculoskeletal Pain

Summary: the purpose of this study is to evaluate the safety and efficacy of an association with one anti-inflammatory and one muscle relaxant agent compared to the one muscle relaxant agent isolated in the treatment of osteomuscular pain in adults.

* double-blind, randomized, multicenter * maximal experiment duration: 9 days * 02 or 03 visits and a phone contact * evaluate the efficacy of an association with one anti-inflammatory and one muscle relaxant agent compared to the one muscle relaxant agent isolated in the treatment of osteomuscular pain in adults. * adverse events evaluation

Eligibility criteria:
iinclusion criteria: * signed consent of the patient; * participants presenting musculoskeletal pain, moderate or moderately severe, with vas (visual analog scale) greater than 40 mm for a period of less than seven (7) days. exclusion criteria: * patients with any clinically significant disease that in the investigator is opinion can´t participate in the study; * patients with any laboratory finding or image finding that in the investigator is opinion can´t participate in the clinical trial; * patients with history of hypersensitivity to any of the formula compounds; * participation in clinical trial in the year prior to this study; * pregnancy or risk of pregnancy and lactating patients; * patients who were in use of drugs that can interfere with evaluation; * history of with rheumatic diseases, fibromyalgia, osteoarticular diseases, dystonia, dystrophies and myopathies, acute infectious diseases, gastric duodenal ulcer or gastritis; * renal or hepatic impairment.
evaluation of safety and efficacy of symbicort® pmdi, with or without spacer, in children (6-11 years) with asthma

Conditions: Asthma

Summary: the purpose of the study is to compare symbicort pmdi with and without spacer in terms of steroid potency, improvement of lung function and asthma symptoms in children with asthma (6-11 years).


Eligibility criteria:
inclusion criteria: * children 6-11 years, diagnosed asthma treated * 6 months, pef * 50% of predicted normal value pre-bronchodilator exclusion criteria: * current systemic glucocorticosteroids usage * current respiratory infection * any significant disease or disorder as judged by investigator

Keywords: symbicort pmdi spacer children
effect of game activity and stress ball on anxiety and vital signs

Conditions: Anxiety; Arthroplasty Complications

Summary: this randomized controlled trial aims to determine the effect of game activity and stress ball use on preoperative anxiety and vital signs in patients undergoing total knee arthroplasty. the primary purpose of the study is to evaluate the effect of these methods (game activity, stress ball use) on patients' anxiety and vital signs. the research involves three groups: one group will engage in a game activity, another group will use a stress ball, and the control group will receive no intervention. patients over 18 years of age who pass the mini-cog test, demonstrate cognitive competence and meet other sampling criteria will be included in the study. data will be collected using the state anxiety scale, a vital signs and pain level form, and a descriptive characteristics form.

preoperative anxiety causes various physiological and psychological reactions. in addition, it is known that preoperative anxiety negatively affects the patient's satisfaction with the surgery, the surgical success rate, and the development of postoperative complications. total knee arthroplasty (tka) is a surgical procedure frequently performed today to relieve pain and restore knee joint function. approximately 30% of patients undergoing tka experience psychological distress before surgery. anxiety is a problem that needs to be managed in tka patients because it negatively affects them in the postoperative period. interventions such as music, funny videos, massage, meditation, hypnosis, vr glasses, and motivational interviewing have been used to reduce preoperative anxiety in adults. these methods can be applied by nurses, are low cost, and have few side effects. gaming activities are also one of the methods used to distract patients and reduce their anxiety levels in the preoperative period. the literature shows that game-based approaches in the management of preoperative anxiety are frequently used with pediatric patients. a stress ball is a method used to draw a person's attention in a different direction by squeezing and loosening the ball held in the palm. although the use of stress balls has not been widely studied in preoperative anxiety management, research shows that stress balls may be useful in anxiety management. game activity and stress ball use are methods that are easy to implement and will not burden patients in terms of cost.

Eligibility criteria:
inclusion criteria: being over 18 years old undergoing total knee arthroplasty having passed the mini-cog test ability to understand, read, and write turkish no hearing or speech problems having a person accompanying the patient exclusion criteria: not wanting to participate in the research unstable general condition sudden change in vital signs having a psychological disorder and using antidepressant medication having any psychiatric or cognitive/mental disease (e.g., dementia) use of psychiatric medication for any reason

Keywords: anxiety vital signs artroplasty
18f-fspg pet/ct as a non-invasive imaging biomarker for treatment response to chemoradiation in esophageal cancer

Conditions: Esophageal Carcinoma

Summary: this study is being done to learn how 18f-fspg pet/ct scan results may be related to the response to chemotherapy and radiation in patients with esophageal cancer.

primary objectives: i. evaluate the ability of 18f-fspg pet imaging to detect tumors in patients with esophageal cancer.

Eligibility criteria:
inclusion criteria: * \* ≥ 18 years of age * patients with locally advanced esophageal cancer * patients with untreated documented carcinoma of the esophagus that is \> 2 cm who are going to receive systemic therapy concurrently with radiation as primary therapy * ability to provide written informed consent in accordance with institutional policies * female subjects of childbearing potential must have a negative serum or urine pregnancy test within 1 week of the proposed investigational pet/ct scan(s) prior to injection of the investigational radiopharmaceutical exclusion criteria: * \* body weight ≥ 400 pounds or body habitus or disability that will not permit the imaging protocol to be performed * pregnant or lactating females * have an allergy to intravenous contrast * egfr \< 30
breaking sitting and metabolic health in sedentary lean adults

Conditions: Metabolic Health; Gut Hormones; Energy Balance

Summary: the purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary lean adults.

two trials are included - prolonged sitting and breaking sitting. in the prolonged sitting trial, after consuming breakfast, participants sat on a chair for 180 min. after 180 min, lunch was provided. after finishing lunch, participants sat on a chair for another 120 min. in the breaking sitting trial, after consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. for the remainder of the time participants sat on the chair. after 180 min, lunch was provided. after finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min. blood samples were collected in a regular pattern throughout the trials. energy balance (e.g., energy intake and spontaneous physical activity) was assessed using food diary and an accelerometer until midnight in the trial days once participants left laboratory.

Eligibility criteria:
inclusion criteria: * physical inactive males and females * aged between 20 and 45 years * lean healthy (waist circumference less than 90 cm for males and 80 cm for females) * weight stable for more than 3 months (no change in weight +/- 3%) * non-smoker * able to walk comfortably on a treadmill exclusion criteria: * personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia * waist circumference \> 90 cm for male and \> 80 cm for female * taking medications that may influence lipid or carbohydrate metabolism or immune system function * unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the physical activity readiness questionnaire (par-q)

Keywords: glp-1 pyy breaking sitting energy balance postprandial glycaemia
blood levels of local anaesthetic in knee arthroplasty

Conditions: Arthritis of Knee

Summary: the primary goal is to evaluate ropivacaine blood concentrations during and after local anaesthetic (ropivacaine) infiltration - the caledonian technique - for total knee replacement surgery. the investigators plan to measure these levels by testing blood samples taken over a timed period. this will allow us to confirm whether the current regimen of local anaesthetic use is within safe limits.

local anaesthetic (la) toxicity may occur when the blood levels of a drug become particularly high. there is a need to confirm that the technique is safe to use. in addition, journal case reports may only describe serious side-effects of toxicity such as abnormal heart rhythms whilst more subtle clinical signs are rarely reported. the investigators would like to study whether or not toxic levels may be approached in some patients or whether more subtle toxicity symptoms and signs are missed. for example, irregular heartbeat, low blood pressure or confusion/agitation. therefore, the investigators intend to study ropivacaine blood levels in patients receiving a total knee replacement in the golden jubilee national hospital. a series of timed samples will be taken during the perioperative period. the anaesthesia and surgery will be performed as routine and no new treatment will be involved. patient demographics, ropivacaine blood levels and clinical observations following la administration will be collected.

Eligibility criteria:
inclusion criteria: * male or female patients greater than 65 years of age exclusion criteria: * patients with a known sensitivity/allergy to ropivacaine or amide-type local anaesthetics * patients who are not suitable for the caledonian technique * patients who refuse or are unable to give consent * patients undergoing bilateral hip replacements * patients with known heart, liver or kidney failure
pilot study of the impact of giant cell arteritis and its treatment on the autonomy of the elderly in the first year of care

Conditions: Giant Cell Arteritis in Dependency of Elderly

Summary: giant cell arteritis is the leading cause of vasculitis in the elderly. no work evaluates its impact on autonomy. at the diagnosis a gerontological evaluation will be carried out including the scores adl, iadl, mna, sf 36, sppb, fried and gds. a monthly telephone reassessment will collect adl and iadl. the end-of-study consultation at m12, conducted by a geriatrician, will have the same scores as at m0. this will make it possible to evaluate the difference in the functional autonomy score between m0 and m12 in the elderly with acg.


Eligibility criteria:
inclusion criteria: * age greater than or equal to 65 years with at least 2 comorbidities \* present, or age greater than or equal to 75 years * diagnosis of acg meeting the diagnostic criteria of acg 1990 acr * comorbidity = chronic pathology exclusion criteria: * neoplastic pathology under treatment * brain pathology with motor disability * dementia at a severe stage (mms \<22/30) * unable to answer the phone * participation in a therapeutic clinical trial

Keywords: giant cell arteritis dependency elderly
assessment of potential interactions between gbr 12909 and cocaine - 1

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to assess potential interactions between intravenous (iv) cocaine and 3 doses of gbr 12909.

this is phase 1, double-blind, placebo-controlled human laboratory clinical pharmacology study that will assess the potential interactions between iv cocaine and 3 escalating oral doses of gbr 12909. the primary objective is to determine safety of gbr 12909 administration and if there are significant interactions between gbr 12909 treatment concurrent with iv cocaine infusions.

Eligibility criteria:
inclusion criteria: * must be within 20% ideal body weight and must weigh at least 45 kg. * must understand the study procedures and provide written informed consent. * must meet dsm-4 criteria and are non-treatment seeking at time of study. exclusion criteria: * please contact study site for more information

Keywords: cocaine dependence
replicating mamatoto in rural tanzania

Conditions: Maternal Death; Newborn Death

Summary: this study aimed to adapt and implement a district-led, policy-based, low cost maternal and newborn health (mnh) intervention package using the mamatoto process, proven successful in uganda, in rural tanzania. the investigators hypothesized that the 'mamatoto package' will be successfully implemented in the misungwi district and will be effective in improving key maternal and newborn health indicators of study participants.

this study collected baseline data on indicators related to pre-natal care, delivery, post-natal care, treatment of childhood illnesses and family planning. data collection tools/strategies included 1) a mapping exercise, 2) health facility audit 3) household surveys and 4) exit interviews. data was collected at baseline and endline. operational data was collected throughout the life of the study. results were used to inform implementation of interventions that aim to improve health facility capacity to deliver good quality care to women and children and to strengthen families and communities to better advocate for and engage in activities that promote healthier women and children. mapping data was collected in two districts 1) misungwi and 2) kwimba. baseline and endline data was collected in misungwi only. the intervention began in misungwi in years 1 and 2 and then rolled out to kwimba in year 3.

Eligibility criteria:
inclusion criteria: * randomly selected households (30) living in selected hamlets with a competent participant of greater than 15 years of age * all women of reproductive age (age 15-49 years old) living in selected households in selected hamlets exclusion criteria: * households with participants that are away for an extended time or have no one home at the time of survey completion

Keywords: maternal and newborn health
quantification of the antidyskinetic effect of amantadine and topiramate in parkinson's disease

Conditions: Parkinson's Disease

Summary: levodopa is the main drug treatment for parkinson's disease. levodopa can cause unwanted and uncontrolled movements called dyskinesias. a drug called amantadine can reduce these movements. to date, there are no objective measures of these movements. the purpose of this study is to measure the reduction of the movements by amantadine and/or topiramate using an objective measure.

nearly all parkinson's disease (pd) patients eventually develop abnormal and unwanted movements (dyskinesias) caused by the gold standard treatment, levodopa. the severity of these movements can range from subtle to extremely debilitating and may or may not interfere with normal activities such as putting on a coat or brushing ones teeth. currently, one of the very few treatments for these unwanted and involuntary movements is amantadine. new options to treat dyskinesia would be clinically very valuable. in a previous study, we developed an objective measuring device to quantify dyskinesia. all pd participants will receive all three of the drug treatment intervention (placebo, amantadine 300 mg, amantadine 300 mg plus topiramate 150 mg). after 2 weeks of one drug treatment, the participants will complete an overnight visit at the octri inpatient unit. during the next day, participants will complete a mental task while standing on a force plate for one minute every half hour until the end of the study. a levodopa iv infusion will occur from 0900 to 1100. the subjects will be split into 'high' and 'low' dose groups. those who take \ 50 mg/hr of oral levodopa to themselves normally will be considered 'high' dose subjects and will received 1.5 mg/kg/hr levodopa. both groups will receive the infusion for two hours from 0900 - 1100. the study drug will be taken orally at 0800.

Eligibility criteria:
inclusion criteria: * parkinson's disease * at least 21 years of age * must be taking oral levodopa * must have dyskinesias by history or previous clinical observation exclusion criteria: * significant cognitive impairment as measured by the montreal cognitive assessment (moca) score of \< 25 * subjects with unstable medical or psychiatric conditions (including hallucinations) * use of dopamine receptor blocking medications (e.g., neuroleptics, certain antiemetics, tetrabenazine) * history of unstable medical conditions (ie active cardiovascular disease, recent unwellness or surgery etc.) * use of anticoagulants * current substance abuse * previous adverse event on amantadine

Keywords: parkinsons disease dyskinesia amantadine efficacy
correlation of paco2 to the inspired and expired oxygen gradient

Conditions: Neurosurgery

Summary: the purpose of this study is to evaluate whether a correlation exists between the partial pressure of carbon dioxide existing within arterial blood and the gradient between inhaled and exhaled fractions of oxygen.


Eligibility criteria:
inclusion criteria: * age 18 to 65. * scheduled for surgical procedure that will last at least 2 hours. * arterial cannulation is planned because of either the complexity of the surgery or patient comorbidity. * at least two arterial blood gas analyses are planned during the surgery. exclusion criteria: * no arterial cannulation is necessary or planned for the procedure.

Keywords: arterial cannulation blood gas carbon dioxide arterial blood oxygen oxygen fractions