Kornimate/medical-research-clean huggingface dataset:
consequence of the learning curve in direct anterior approach for total hip replacement

Conditions: Arthropathy of Hip; Surgery

Summary: background: direct anterior approach to the hip (daa) is being considered as one of the most promising minimally-invasive approaches in total hip arthroplasty (tha). purpose of this study is to analyse influence of learning curve on clinical and radiographic outcome in direct anterior approach (daa) for total hip replacement. methods: the first 30 patients operated with daa (group b) were compared to 39 patients operated by hardinge approach (group a). peri-and postoperative complications, harris hip score (hhs), implant positioning, experienced pain and patient satisfaction were evaluated at a mean follow-up of 32 months.

direct anterior approach to the hip (daa) is being considered as one of the most promising minimally-invasive approaches in total hip arthroplasty (tha). purpose of this study is to analyse influence of learning curve on clinical and radiographic outcome in direct anterior approach (daa) for total hip replacement. methods: the first 30 patients operated with daa (group b) were compared to 39 patients operated by hardinge approach (group a). peri-and postoperative complications, harris hip score (hhs), implant positioning, experienced pain and patient satisfaction were evaluated at a mean follow-up of 32 months.

Eligibility criteria:
inclusion criteria: * hip arthritis exclusion criteria: * bmi\>35
sienna+mr long-term uptake

Conditions: Breast Cancer Female

Summary: in a previous study in 2012/2013 patients were injected a superparamagnetic iron oxide for sentinel lymph node detection. in this follow up study we want to investigate how much of this tracer is still detectable.


Eligibility criteria:
inclusion: * participation in previous study * informed consent * no contraindications for mri scan exclusion: * contraindications for mri scan
effect of a 'rapid-return-to-work program' in mild mental disorders.

Conditions: Mental Disorder

Summary: this study is a pragmatic randomized controlled trial (rct) evaluating the effect of brief versus short psychotherapy in subjects with substantial mental complaints.

running evaluations of the brief intervention (bi) at our outpatient clinic preceding to this study had given us the impression that the patients obtained a more active coping style towards their health problems with consequential enhanced work participation (wp). these evaluations, in addition to our experiences in bi for low back pain (lbp) has generated the current hypothesis of this study towards wp. yet, the sustainability of wp and long-term effects on mental health remained questionable. in this pragmatic rct the objective was to compare brief psychotherapy with focus on normalization and coping (brief-pst) with short-term psychotherapy of standard duration with more extended focus (short-pst), as otherwise used at the mental health services. the primary aim of this study was to assess differences in effect on wp and the secondary aim was to assess differences in clinical response. the investigators hypothesized that in the short term, brief-pst could facilitate or sustain wp in a superior fashion to short-pst in persons who are on, or at risk of sick leave due to mental health problems. although the investigators expected a substantial long-term rate of clinical recovery and reduction in mental health-related symptoms in both groups, the investigators had no specific hypothesis regarding the extent and direction of possible group differences in these clinical measurements.

Eligibility criteria:
inclusion criteria: * 'mental complaints' was the main reason for referral to the outpatient clinic * employed and on or at risk of sick leave exclusion criteria: * acute or severe pathology that required greater input than the clinic could offer, * sick-leave had \> 9 months during the preceding 2 years

Keywords: return to work brief intervention
assessment of potential interactions between cocaine and rpr 102681 - 1

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to assess potential interactions between iv cocaine and rpr 102681

phase i, double-blind, placebo-controlled dose escalating assessment of potential interactions between intravenous cocaine and rpr 102681

Eligibility criteria:
inclusion criteria: includes but is not limited to: * non-treatment seekers * dsm-iv criteria for cocaine abuse or dependence * ability to verbalize understanding of consent form and provide written informed consent and verbalize willingness to complete study procedures; be able to comply with protocol requirements exclusion criteria: please contact site for more information.

Keywords: cocaine dependence
cpap therapy in obstructive sleep apnea patients with pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: all patients are newly diagnosed obstructive sleep apnea patients performing full night polysmnographic sleep study, whose echocardiographic findings elucidate presence of pulmonary hypertension(ph). these patients seemed to have ph if mpap ≥25 mmhg . all studied patients were received cpap therapy with average cumulative adherence ⩾4 h/day of \>70% nights \[380\] obtained from device download with ahi\<5 /hr echocardiography: it was performed initially to diagnose pulmonary hypertension and repeated after three months of cpap therapy as a follow up . all enrolled patients were subjected to trans-thoracic echocardiography using ultrasound system (vivid i, ge healthcare, little chalfont, uk), with a 2.5 mhz transducer. certain measurements were then used to calculate mpap. patients were considered to have ph if mpap ≥25 mmhg, and were classified into mild (20-40 mmhg), moderate (41-55 mmhg), and severe (\>55 mmhg) degrees. evidence of ph is found by doppler echocardiography showing an elevated right ventricular systolic pressure (rvsp).


Eligibility criteria:
inclusion criteria: all patients are newly diagnosed obstructive sleep apnea patients performing full night polysmnographic sleep study, whose echocardiographic findings elucidate presence of pulmonary hypertension(ph). exclusion criteria: * patients aged \< 18 years * patients with secondary ph, due to pulmonary diseases, or left ventricular heart diseases , or chronic thromboembolic disorders. * patients on long term oxygen therapy (ltot). * patients with respiratory neuromuscular weaknesses or chest wall deformities. * end-organ failure and malignancies * obesity hypoventilation syndrome.
the effect of foot deformities on physical activity, fatigue level and quality of life in elderly copd patients

Conditions: Chronic Obstructive Pulmonary Disease; Foot Deformities; Quality of Life; Activity, Motor; Fatigue

Summary: the aim of this study is to investigate the effects of changes in foot structure on physical activity level, fatigue and quality of life in copd patients.

chronic obstructive pulmonary disease (copd) is usually a progressive disease associated with the increased chronic inflammatory response of the airways and lungs to the toxic effects of harmful gases and particles. it causes pathological changes such as increased secretion production in the airways, epithelial changes, inflammation, smooth muscle hypertrophy, and hyperplasia in the submucosal glands. hyperinflammation in the lungs results in muscle atrophy, shortening of the respiratory muscles, and increased respiratory workload. on the other hand, the increase in pro-inflammatory plasma cytokine levels seen in the systemic circulation causes oxidative stress, leading to the development of musculoskeletal system disorders and a decrease in functional capacity. pulmonary dysfunction and increased dyspnea lead to a decrease in physical condition, physical exercise tolerance, and activity, while the decrease in muscle mass results in atrophy in the peripheral extremities. age and gender are cited as major risk factors for copd. therefore, lower extremity atrophy, which is seen in peripheral extremities and increases with aging, causes foot dysfunctions. considering that the ability of elderly people to maintain their independence is related to a good level of consciousness and ongoing ambulation, and the frequency of foot problems seen in elderly people is approximately twice as high as the general population, foot problems seen in elderly individuals are very important for this group. in particular, the decrease in foot mobility and the fall of the medial longitudinal arch negatively affect the absorption of shocks during heel strike and foot flat and the momentum of the trunk forward. this situation may result in the expenditure of energy above normal and deterioration of balance while ensuring the proper transfer of body weight. all of these cause early fatigue and a decrease in the quality of life in the individual. in the literature, foot deformities in elderly healthy individuals and the parameters these deformities will affect people are stated. however, there is no study examining the effects of foot deformities on physical activity, fatigue, and quality of life in elderly copd patients.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of copd * age over 60 exclusion criteria: * having an orthopedic or neurological disorder that affects the walking pattern * having a peripheral vascular disease * being diagnosed with diabetes mellitus * having systemic diseases such as arthritis * having a previous history of foot-ankle fractures * having a dermatological disease (fungal and bacterial infection etc.)

Keywords: chronic obstructive pulmonary disease foot deformities quality of life physical activity fatigue geriatric patient
a study to find a safe dose of volasertib given in addition to standard salvage chemotherapy in children (age 3 months to less than 18 years) with acute myeloid leukaemia, in whom front-line chemotherapy failed

Conditions: Leukemia, Myeloid, Acute

Summary: this is an open-label, dose-escalating trial to evaluate the mtd and/or dose to be used for further development by evaluation of dlt in course 1 and the safety of volasertib when added to standard intensive salvage chemotherapy with dnx-fla in paediatric patients with aml after failure of first-line therapy. furthermore, data on efficacy and pk/pd of volasertib in paediatric patients with aml when added to standard intensive salvage chemotherapy will be collected.


Eligibility criteria:
inclusion criteria: * patients 3 months to \<18 years of age at the time of informed consent * patients with aml after failure of the front-line intensive aml therapy * lansky score at screening \>=50 for patients from 3 months to \<12 years * karnofsky score at screening \>=50 for patients from 12 to \<18 years * use of highly effective methods of birth-control, if sexually active * parents/legal guardians and patients have given written informed consent and informed assent suitable for the respective age group exclusion criteria: * down syndrome * acute promyelocytic leukaemia and treatment-related aml * qtc prolongation * lvsf \<30% * cardiac disease and/or dysfunction * active uncontrolled infection * hiv infection, acute or chronic hepatitis * inadequate lab parameters * impaired renal function * pregnancy or nursing * further exclusion criteria apply
interest of narrow band imaging in detection of upper aerodigestive cancers

Conditions: Squamous Cell Carcinoma of Oropharynx; Squamous Cell Carcinoma of Hypopharynx; Squamous Cell Carcinoma of Larynx

Summary: the aim of this study is to prospectively determine if the use of nbi endoscopy modifies the superficial extension of these tumors.

several studies have already showed the interest of the use of nbi for the early diagnosis of malignancies of the upper aerodigestive tract. for all tumors, the most accurate evaluation of its limits is very important to perform the best strategy of treatment. if surgery seems to be the best option, surgical margins must be widely healthy. despite the systematic transnasal flexible endoscopy with white lamp followed by laryngoscopy under general anesthesia (lga) and tomodensitometric evaluation, surgical margins can be unhealthy (in situ carcinoma or dysplasia). we propose to evaluate if the use of the nbi could be useful to determine the superficial spread of squamous cell carcinomas in these locations. to april 2013 to mars 2015, all patients with a suspicion of squamous cell carcinoma of the oropharynx, hypopharynx or larynx and whom a lga are expected, are included. the day before the lga, two endoscopies by two different physicians were performed for each patients and recorded: the first one with white light and the second one with nbi. all results are noted on a schema. superficial extension or synchronous lesions showed by nbi are analysed and compared with with lamp technic. after surgery, surgical margins were evaluated and healthy margins were measured.

Eligibility criteria:
inclusion criteria: - patients who can benefit a laryngoscopic exam under general anesthesia exclusion criteria: * general anesthesia contra-indications * local anesthesia allergy * breast-feeding period or pregnancy

Keywords: nbi, squamous cell carcinoma, pharynx, larynx, surgical margins.
study on cardiovascular health, nutrition and physical functioning in older adults in spain

Conditions: Physical Disability; Cognitive Dysfunction

Summary: population aging makes it necessary to identify factors related to unhealthy aging. the purpose of this study is to examine the association between ideal cardiovascular health, diet and other lifestyles and biological risk factors (either clasical or emergent) and the risk of physical and cognitive function impairment and mortality in a cohort of community-living individuals aged 65 years and over.


Eligibility criteria:
inclusion criteria: * non-institutionalized residents in the region of madrid, spain. * 65 years and over exclusion criteria: * none

Keywords: cardiovascular health diet functional limitations frailty older adults
decreasing physician burnout with professional coaching

Conditions: Burnout, Professional

Summary: the goal of this randomized control trial is to learn if professional coaching can help reduce physician burnout among physicians at ucla. the main aims of the study are: * to reduce burnout among physicians with professional coaching * improve work satisfaction and engagement, sense of self-efficacy and social support with professional coaching * determine the efficacy of one-on-one professional coaching and small group professional coaching combined with behavioral interventions/activities in reducing physician burnout and comparing these groups to one another and to a delayed-entry (control) group participants will be randomly assigned into one of three groups: * intervention group 1: one-on-one coaching (n=30). six one-on-one coaching sessions via zoom with one of two private professional coaches every other week for 3-4 months. * intervention group 2: coach-facilitated group sessions and coach-guided activities/behavioral interventions (n=30). six small-group coaching sessions via zoom with one of two private professional coaches and three physician participants in each group, every other week for 3-4 months. * delayed-entry group 3 (n=30): no intervention during duration of study period. note: once participation in the pilot study has been completed for groups 1 and 2, physicians participating in group 3 will be offered to participate in six one-on-one sessions with a private professional coach over a 3-4 month period. participants will complete several surveys that assess for burnout, work engagement and satisfaction, sense of social support and isolation, and areas of worklife) before the start, upon completion of the intervention and again at 6 months upon completion of the sessions for the delayed-entry group. each group also received coach-guided activities/behavioral interventions during coaching sessions. these activities will be sent by coaches to participates throughout the 3 month period and include, but are not limited to: wheel of life, visioning exercise, one page miracle: core values, purpose, and goals, buckets and mental models.


Eligibility criteria:
inclusion criteria: * actively practicing ucla department of medicine physicians who had at least two years of employment at ucla exclusion criteria: * current or anticipated (in the next 6 months) participation in one-on-one or group coaching provided by a professional coach

Keywords: physician burnout coaching work engagement
health-related quality of life of women with polycystic ovary syndrome at sohag university hospital

Conditions: Polycystic Ovary Syndrome (PCOS) Women

Summary: it is well-established that pcos women suffer from anxiety, depression, and markedly reduced qol ,but there has not yet been a nationally representative study to evaluate the pcos health related qol and factors affecting it among women in egypt. so here we try to cover this gap in this study that will be designed to record the qol of women with pcos and factors affecting it. this study aims to assess the health related quality of life of polycystic ovary syndrome and determine factors affecting the hrqol


Eligibility criteria:
inclusion criteria: * • female cases between 18 and 45. * females diagnosed with pcos per rotterdam criteria , the most commonly accepted and used for pcos, a diagnosis is confirmed if any two of the three features (hyperandrogenism, oligomenorrhea or anovulation, and polycystic ovaries) are present in a woman of reproductive age exclusion criteria: * • females below 18 years old. * females above 45 years old. * patients having major life event or problem also affecting quality of life.

Keywords: pcos quality of life pcosq bmi
q-gain (using qpop to predict treatment for gastrointestinal cancer)

Conditions: Gastrointestinal Cancer

Summary: this is a multi-cohort proof of concept study involving patients with metastatic gastrointestinal cancers. in the first cohort of treatment-naïve patients, the investigators intend to create cancer organoids for 100 subjects. then, the investigators intend to evaluate ex-vivo prediction of treatment outcomes using qpop (see section 4.0 for detailed sample size calculation). patients enrolled on study will undergo a fresh biopsy of tumour lesion to obtain cells that will be used to generate patient-derived tumour organoids. these patients will go on to receive standard of care first-line chemotherapy +/- targeted therapy. organoids will then be subjected to up to a 14-drug panel screening. the drugs in the respective drug panel have been shown to have activity in the respective cancers and would be used in the standard-of-care setting by treating physicians.

hypothesis: ex-vivo sensitivity testing on patient derived tumour organoids using qpop can identify drug combinations which may have clinical efficacy against metastatic gastrointestinal cancer. specific aim 1: to grow patients' gastrointestinal tumour-derived organoids. specific aim 2: to perform ex-vivo drug sensitivity testing on patient derived tumour organoids using qpop for metastatic gastrointestinal cancers. specific aim 3: asses the efficacy of phenotype directed therapy using qpop to assign treatment after progression of standard of chemo for gastric cancer.

Eligibility criteria:
inclusion criteria: - patients may be included in the study only if they meet the following criteria: 1. treatment naïve patient with gastrointestinal cancers (i.e. oesophageal, gastro-oesophgeal, gastric, small bowel, colorectal, hepatocellular, pancreatic and biliary tract) fit and planned for first line treatment, or 2. chemo-refractory patients with gi cancers deemed by investigator to be fit for clinical trial 3. age ≥ 21 years 4. ecog ps 0-1 5. at least 1 tumour lesion amenable to fresh biopsy 6. at least 1 measurable tumour lesion based on recist v 1.1 criteria 7. estimated life expectancy of at least 24 weeks 8. adequate organ function , including: 1. pre-biopsy o bone marrow: * absolute neutrophil (segmented and bands) count (anc) ≥1.5 x 109/l * platelets ≥ 100 x 109/l * pro-thrombin within uln * hemoglobin ≥ 8 x 109/l 2. pre-treatment * bone marrow: * absolute neutrophil (segmented and bands) count (anc) ≥1.5 x 109/l * platelets ≥ 100 x 109/l * hemoglobin ≥ 8 x 109/l * hepatic: * bilirubin ≤ 1.5 x upper limit of normal (uln), * alt or ast ≤ 2.5x uln, (or ≤ 5 x with liver metastases) * renal: * creatinine ≤ 1.5x uln 9. signed informed consent from patient or legal representative 10. able to comply with study-related procedures. 11. recovery from prior toxicity to g1, excluding alopecia. exclusion criteria: * there are no specific exclusion criteria if patients meet the inclusion criteria

Keywords: qpop
pcr technic evaluation in the microbial diagnostic of septicemia in hemodialysis patients with catheter.

Conditions: Septicemia in Hemodialysis

Summary: the aims of this study are to evaluate the pcr on whole blood approach to determine rapidly both the susceptibility and the identification of staphylococcus responsible of septicemia in patients under hemodialysis with catheter. the results obtained with this novel experimental approach will be compared to those obtained on the same clinical samples by the routine diagnostic laboratory.

the outlook of current trends indicates that maximum effort is needed to tailor the initial antimicrobial therapy in patients under hemodialysis with catheter. specific emphasis is put on early availability of antimicrobial susceptibility results by diagnostic laboratories to optimize the management of those difficult infections. direct whole blood pcr could allow a rapid determination of bacterial susceptibility to antibiotics. the study is designed to assess the concordance of a direct whole blood pcr targeting staphylococcus and its susceptibility to oracillin with the classical microbiological approach of samples from hemodialysis patients with catheter suspected of septicemia. this innovative approach should allow a faster diagnostic allowing the clinicians to better tailor the initial empirical antimicrobial therapy which has been proven crucial for a good clinical management of the patients. moreover, the use of an adequate antimicrobial therapy early in the management of the patients, should not only lead to a better clinical outcome but also avoid unnecessary prescriptions of drugs which are the main drivers of the emergence and spread of antimicrobial resistance.

Eligibility criteria:
inclusion criteria: * patients over 18 year old, * suspicion of septicemia in hemodialysis patient with catheter, * patient oral consent prior to inclusion in the study. exclusion criteria: * patients who went through the a\&e department, * patients who have received an antimicrobial therapy more than 8 hours long, * patient under legal protection.

Keywords: pcr hemoculture septicemia