Kornimate/medical-research-clean huggingface dataset:
general practice quality assurance project. chronic obstructive pulmonary disease (copd) diagnosis and treatment

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: a cross sectional observational quality assurance project in general practice to copd diagnosis and treatment


Eligibility criteria:
inclusion criteria: * copd patients over 35 years of age * more than two annual renewals with the following group of inhalation preparations: anticholinergic, beta-2 antagonists, steroids or a combination of these exclusion criteria: * asthma
tow maxillary hybrid expanders screw supported versus lateral angulated one; a prospective randomized clinical study

Conditions: Cross Bite

Summary: in this study i will use to different designs of t maxillary hybrid expanders that consists of hyrex supported with tow miniscrews to treat the collapsed maxilla in yonge adolescents

the maxilla is expanded by tow diffrent designs of maxillary hybrid expanders

Eligibility criteria:
inclusion criteria: 1. medically free male or female patients 2. patients that necessitated maxillary expansion due to constricted maxillary arch shown by a unilateral or bilateral posterior crossbite. 3. the patient should have no missing teeth except third molars. 4. age ranged from 12 to 18 years old. 5. the patient should have a good gingival condition. 6. the patient should have a good periodontal condition. exclusion criteria: 1-hisory of previous orthodontic treatment. 2- lack of cooperation. 3- mental problems. 4- skeletal open bite. 5- tmj problem. -
increasing availability of lower energy meals on food choice and intake

Conditions: Diet, Healthy; Food Selection; Obesity; Eating Behavior

Summary: this study will examine the effectiveness of a structural intervention (baseline proportion of lower energy ready meals vs increased proportion of lower energy ready meals) on calories (kcal) ordered and consumed. the study will use a within-subjects design, meaning all participants will be exposed to both conditions (baseline vs increased lower energy meal menus). the procedure will involve participants placing orders for supermarket ready meals, which are then delivered to their homes for their consumption. this study will also investigate whether the effectiveness of the intervention varies, depending on socioeconomic position (sep). the primary hypothesis is that increasing proportion of lower energy options will decrease total kcal ordered and consumed, and that there will be no difference between higher and lower sep. to address the limited evidence on longer term impacts of dietary interventions on daily energy intake, the present study will also examine post-meal energy consumption up to midnight on the following day. finally, this study will explore the psychological processes that might underlie the effectiveness of the intervention among individuals with higher and lower sep; namely, food choice motives, satiety responsiveness, plate clearing tendencies, and food waste concerns.

see attached protocol documents.

Eligibility criteria:
inclusion criteria: * uk (united kingdom) residents, aged 18 or over * fluent in english * have access to a phone/tablet/computer device which has access to internet and a functioning camera * willing to consume two supermarket ready meals * have access to a functioning microwave and oven for the preparation of the ready meals exclusion criteria: * taking part more than once * another member of the same household has participated in the study (multiple members of the same household will not be allowed to take part) * current or historic diagnosed eating disorders * currently on any medication which affects appetite * any of the following dietary restrictions, intolerances, or allergies (vegetarian, vegan, gluten-free, sugar-free, dairy/lactose-free, food allergy - such as milk, eggs, nut, wheat, fish, etc) * history of severe childhood allergies, anaphylaxis or anaphylactic shock

Keywords: availability socio-economic position food choice eating behaviour
evaluation of the contribution of regular cognitive exercises to treatment in patients with alzheimer's disease

Conditions: Alzheimer Disease; Cognitive Change

Summary: in this study, it is aimed to compare the effects of cognitive exercises applied on long-term internet environment to the cognitive level of patients who received donepezil, memantine or donepezil / memantin combination therapy.


Eligibility criteria:
inclusion criteria: * patients between 55-90 years old who were diagnosed with alzheimer's dementia and had no history of cerebrovascular disease during the last 6 months, * patients without other neurodegenerative diseases and secondary dementia diagnoses, * patients with moca score of between 13-18, * patients with at least primary school graduation, * patients who have had no cns disease including trauma in the last year, * patients without a diagnosis of psychiatric disease, * patients with a tablet or pc with an internet connection, * patients agreeing to perform beynex daily activity at least 5 times per week, * patients signing informed consent form. exclusion criteria: * patients who have hypersensitivity to study working drugs, * psychotic patients, * disabled patients with orthopedic dominant extremity, * patients with icu follow-up due to trauma in the last 6 months, * patients with severe visual impairment or eye surgery, * patients who refuse to sign the informed consent form.

Keywords: alzheimer disease cognitive exercises internet donepezil memantin combination
the effectiveness of acrylic and clear aligners in the treatment of anterior crossbite in children

Conditions: Anterior Crossbite

Summary: to evaluate the treatment efficacy, treatment duration, and cephalometric changes, as well as the impact on quality of life, of clear aligners and labiolingual spring hawley appliances in the treatment of pediatric patients with anterior crossbite.

two groups were treated with clear aligners and labiolingual springs hawley and the study consisted of 30 patients, 15 patients in each group. cast analysis and cephalometric analysis were performed at pretreatment and posttreatment. quality of life was assessed at the end of treatment for both groups.

Eligibility criteria:
inclusion criteria: 1. in the mixed dentition phase, aged between 7-12 years 2. with a dental class i molar relationship according to angle's classification 3. anb within the normal range i.e. (the crossbite will be diagnosed as dental) 4. exhibiting anterior crossbite (ac) in at least one permanent incisor in the sagittal plane 5. no prior orthodontic treatment for any reason 6. no history of maxillofacial trauma 7. no systemic diseases or syndromes that may interfere with treatment 8. able to attend regular appointments and cooperate with instructions throughout the treatment process exclusion criteria: 1. patients with functional anterior crossbite associated with mandibular functional shift 2. patients with clinically evident retrognathia or prognathia of the maxilla or mandible 3. patients with severe gingivitis or periodontitis 4. patients with known allergies to the materials to be used in the treatment 5. patients with severe dental anomalies (e.g., supernumerary teeth, missing teeth, dental malformations) 6. patients with serious emotional or psychological issues that may hinder treatment compliance

Keywords: anterior crossbite cephalometric analysis clear aligners labiolingual spring hawley quality of life
ventricular tachycardia mechanisms

Conditions: Ventricular Tachycardia

Summary: the purpose of this study is to understand why certain hearts have ventricular arrhythmias and help identify areas of the heart that cause arrhythmias. there is still a significant gap in understanding why ventricular arrhythmias occur. this study will examine the electrical properties of the heart tissue to understand how these arrhythmias occur, and hopefully identify areas that might lead to ventricular arrhythmias. the hope is that studying this might be able to improve outcomes during ventricular tachycardia (vt) ablations.

ventricular tachycardia (vt) ablation remains the cornerstone treatment for drug refractory vt. previous studies have reported success rate of vt ablation ranging from 23 to 49%. despite improvements in mapping and catheter technology, there is a high recurrence rate and numerous patients who fail vt ablation. reasons for failure in vt ablation include the inability to identify critical areas of myocardium responsible for vt and hemodynamic instability of vt during mapping. several studies have attempted to study electrical properties of cardiac tissues to identify potential circuits in sinus rhythm avoid mapping during unstable vt. this includes mapping fractionated electrical potentials, isochronal late activation mapping (ilam), and ablation of low voltage regions. however, these techniques have yielded modest improvement in success rates with poor specificity of identifying important regions. monophasic action potentials (map) demonstrate cellular action potential of the myocardium. recent evidence suggests that changes in map morphology can predict sudden cardiac death by ventricular arrhythmias. however, cellular activation has not been studied in vt. the researchers of this study propose that map signals can better elucidate electrophysiological characteristics of the myocardium, and thus identify sites critical to vt. during a standard of care vt ablation, the researchers will use the map catheter to study cellular action potential of the ventricular myocardium, which cannot be done on traditional catheters. the design of this catheter is similar to other diagnostic catheters that are currently used for vt ablation. the map catheter is a bipolar catheter, two with electrical poles at the distal tip. the catheter is placed on the myocardium (similar to other traditional catheters) and a recording signal is transmitted to the workstation. using the map catheter the will not interrupt or distort any of the standard treatment procedures.

Eligibility criteria:
inclusion criteria: * diagnosis of ischemic cardiomyopathy * single or dual chamber implantable cardioverter-defibrillator (icd) exclusion criteria: * non-ischemic cardiomyopathy * contraindication to catheter ablation * severe peripheral arterial disease or medical condition that prohibit arterial access * ventricular tachycardia (vt) or sudden cardiac arrest (sca) within 30 days of acute coronary syndrome or within 90 days of coronary revascularization

Keywords: ventricular tachycardia ablation
relative risk of hypertension among obese

Conditions: Obesity

Summary: observational study was conducted to determine the relative risk of hypertension among young adult obese population of pakistan with age between 25-40 years


Eligibility criteria:
inclusion criteria: adult population with age between 25- 40 years having normal weight or obesity of grade i and ii, with or without hypertension. exclusion criteria: patients with co-morbid like diabetes mellitus, dyslipidemia, and cardiovascular disorder were excluded from the study
tysabri global observational program in safety

Conditions: Multiple Sclerosis

Summary: the primary objective of this study is to determine the incidence and pattern of serious infections, malignancies, and other serious adverse events (sae) in participants with multiple sclerosis (ms) treated with tysabri (natalizumab).

the tysabri global observational program in safety (tygris) is a safety observational cohort program designed to obtain long-term safety data in multiple sclerosis (ms) participants treated with natalizumab in a clinical practice setting in the united states or canada.

Eligibility criteria:
key inclusion criteria: * ms patients in the us and canada receiving tysabri under standard clinical care for less than or equal to 3 infusions are eligible to participate in tygris. note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: natalizumab ms tysabri multiple sclerosis tygris
effect of controlled diet combined with a fermented milk product on gas-related symptoms

Conditions: Functional Gastrointestinal Disorders

Summary: to select among different dietary and clinical conditions the most appropriate to assess the impact of a fermented milk product on gas-related symptoms

to select among different dietary (mild or high flatulogenic diet) and clinical conditions (fgid or non-fgid population) as well as different measured parameters (self-completed questionnaires assessing gas related symptoms, digestive well-being and bowel functions, gas volume distribution in the colon by mri, volume and composition of gas collected per anus and frequency of gas evacuations per anus), the most appropriate to assess the impact of a fermented milk product on gas-related symptoms.

Eligibility criteria:
inclusion criteria: * 1=fgid group: subject with body mass index (bmi) between 18.5 and 30.0 kg/m2 (bounds excluded); subject with a functional gastrointestinal disorder according to rome iii criteria; subject complaining of excessive intestinal gas evacuation (i.e. flatulence); subject willing to follow strict dietary instructions; subject who normally consumes dairy products; * 2=non-fgid group: subject with body mass index (bmi) between 18.5 and 30.0 kg/m2 (bounds excluded); subject with no functional gastrointestinal disorder according to rome iii criteria; subject with no gastrointestinal disorders according to investigator's medical assessment; subject willing to follow strict dietary instructions; subject who normally consumes dairy products exclusion criteria: * 1=fgid group: subject with any disease/disorder which can interfere with the gas collection; subject with any antecedents of digestive surgery; subject with any intake of antibiotics in the previous 2 months; subject with any current use of any medication with potential central nervous system effects (except for chronic treatment with anxiolytics and antidepressants started at least 3 months before inclusion in the study); subject taking drugs that might modify gastrointestinal function (except for chronic treatment with laxatives, started at least 3 months before inclusion in the study) ; * 2=non-fgid group: subject with any disease/disorder which can interfere with the gas collection; subject with any antecedents of digestive surgery; subject with any intake of antibiotics in the previous 2 months; subject with any current use of any medication with potential central nervous system effects; subject taking drugs that might modify gastrointestinal function

Keywords: flatulence gas probiotics fermented milk diet functional gastrointestinal disorders
determine effects of adjunctive levetiracetam on sleep architecture in adults with partial onset epilepsy.

Conditions: Epilepsy, Partial

Summary: effect of adjunctive levetiracetam on polysomnography in adults with partial-onset epilepsy receiving a classical antiepileptic drug


Eligibility criteria:
inclusion criteria: * subjects must have partial onset epilepsy and have been taking carbamazepine or phenytoin at a stable dose for a period of 4 weeks prior to the selection visit * subjects must have controlled partial onset seizures which can potentially benefit from adjunctive treatment exclusion criteria: * subjects dosing with lev two weeks prior to the selection visit * subjects using more than one aed * subjects with specific and non-specific sleep disorders

Keywords: levetiracetam, adult, partial-onset epilepsy, antiepileptic
type 2 diabetes affect exercise induced improvement in insulin sensitivity

Conditions: Insulin Sensitivity/Resistance

Summary: this study investigates weather a family history of type 2 diabetes affects exercise induced improvements in insulin sensitivity in the hispanic population

a family history of t2d (fh+) is a risk factor for developing insulin resistance (which precedes t2d) and t2d (ryder et al., 2003). exercise training on the other hand has been shown to improve insulin sensitivity and is highly effective to prevent/manage t2d. however it is not known if early signs of insulin resistance appear before being clinically diagnosed and if the benefits of exercise which prevent/cure t2d, are limited to the offspring of hispanic t2d parents. therefore, the proposed study will determine 1) if normoglycemic (normal blood glucose) offspring of t2d parents are insulin resistant, using the gold standard method to measure insulin sensitivity and metabolic flexibility (ability to switch between carbohydrate and fat oxidation) 2) if 8 weeks of exercise training improves insulin sensitivity and metabolic flexibility to the same extent in fh+ compared to normoglycemic offspring of parents without any history of t2d (fh-) and 3) if 8 weeks of exercise training will change the blood, lipid and molecular profiles relevant to insulin sensitivity to same extent in fh+ compared to offspring of parents without family history of t2d (fh-).

Eligibility criteria:
inclusion criteria: * 18 ≤ age ≤ 40 years * 18 ≤ bmi ≤ 30 kg/m2 * both parents are mexican/mexican-american) * sedentary lifestyle * less than 60 minutes/wk. of structured exercise * physical activity level ≤ 1.4 exclusion criteria: * evidence of significant cardiovascular disease or diabetes * a fasting blood glucose ≥100 mg/dl * screening blood pressure \>140/90 * hyperlipidemia * use of drugs affecting energy metabolism or body weight * excess alcohol, drug abuse, and smoking * eating disorder or eating attitudes interfering with study * unwillingness to be abide by randomization
eeg alterations in preterm infants with thyroid dysfunction

Conditions: Transient Hypothyroxinemia of Prematurity

Summary: the aim of this study is to investigate differences in electroencephalography (eeg) evolution between preterm infants with and without transient hypothyroxinemia of prematurity (thop) in order to find differences in the interburst interval and the background pattern and in the maturation of the sleep-wake cycle.

1. definition of thop the determination of thyroid hormones (th) are assay-specific and related to the infants' gestational age (ga) and moment of determination. immediately after birth, there will be a surge of th, subsequently followed by a decrease to basal levels. therefore, it is difficult to obtain reference values. the investigators plan to set out specific reference values for the preterm patient population, based on the th laboratory results of cord blood, performed in the clinical laboratory of uz leuven and available over the last 4 years. the results will be linked to the gestational age. dependent whether the data distribution is normal or not, the investigators are planning to use standard deviations or percentiles to classify patients. 2. eeg findings in this retrospective study, quantitative eeg- sleep behavior at (near) term age (ga 36-44 weeks) in preterm infants born \<28 weeks ga, will be analyzed (n = 87). eegs were taken in the framework of the resilience study and hereby, parental informed consent was already obtained. th function is assessed in preterm infants ≤ 34 weeks as part of the clinical care protocol. no additional blood samples were taken. quantitative eeg measures will be compared between the preterm infants with thop (circulating thyroxine levels\< p10) and without thop. logisitic regression will be performed to determine the effect of thyroid function as well as other clinical and demographic variables, on functional brain development at term equivalent age. these results will also be linked to long-term neurodevelopment outcome. in a subgroup of these preterm patients (n=42) sequential eegs, recorded during their stay at the neonatal intensive care unit, are available. these eegs will be analyzed in a fully automatic way to assess functional eeg- brain maturation. in this way, the investigators want to investigate whether deviations of normal preterm eeg-brain maturation can be discerned in preterm neonates with thop and without thop. in preterm infants with ga \< 32 weeks, developmental follow up data are available at the corrected age of 9 months and 2 years (follow up convention). the investigators will use these results and link them to the eeg findings and thop data.

Eligibility criteria:
inclusion criteria: * gestational age \< 28 weeks * serial eeg recordings available * thyroid function test on the first day of life and at the end of the first week of life available exclusion criteria: * presence of congenital abnormalities

Keywords: eeg
de novo lipogenesis of sebaceous glands in acne

Conditions: Acne Vulgaris

Summary: there are two purposes of this study: 1. first, the investigators want to see what the differences are in de novo sebaceous lipid production of people with and without acne. 2. secondly, the investigators want to know what happens to sebaceous gland de novo lipid production before and after treatment with topical tretinoin and oral isotretinoin.

the primary objective of this study is to understand how de novo lipid production of sebaceous glands are altered in acne and with acne directed therapy. hypothesis 1: the overall de novo lipogenesis will be increased in those with acne hypothesis 2: treatment with topical tretinoin and systemic isotretinoin will reduce de novo lipogenesis.

Eligibility criteria:
inclusion criteria: * age 15 to 45 years of age * subject/parents/legal guardian be able to read and comprehend study procedure and consent forms * have acne that is diagnosed by a board certified dermatologist * meet one of the following criteria: * already been prescribed oral isotretinoin for treatment of acne * have already been prescribed a topical retinoid * eligible for prescription of topical tretinoin exclusion criteria: * those who have already initiated or completed a course of systemic isotretinoin * those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome * those who are pregnant in female participants * those who do not fit the inclusion criteria

Keywords: acne sebaceous gland lipid sebum