Kornimate/medical-research-clean huggingface dataset:
turkish version of the glaucoma quality of life-15 questionnaire

Conditions: Glaucoma; Quality of Life

Summary: glaucoma is a disease with irreversible loss of visual field and optic neuropathy and is the most important cause of irreversible vision loss after cataract in the world. although clinical evaluations reveal the level of glaucoma quantitatively, it is necessary to evaluate the impact of this pathology on daily functions and quality of life with a holistic perspective and to provide appropriate advice to patients according to the information obtained. glaucoma quality of life -15 questionnaire (gqol-15) was developed by nelson et al. in 2003 to evaluate the quality of life of glaucoma patients. the aim of this study is to translate gqol-15 into turkish and evaluate its test-retest reliability for turkish-speaking population.


Eligibility criteria:
inclusion criteria: * diagnosis of primary open angle glaucoma more than 6 months with visual field tests, * have the sufficient cognitive level to answer the scale questions. exclusion criteria: * to have retinal or optic nerve pathologies that may cause loss of visual field or decrease in visual field except glaucoma, * to undergo eye surgery in the last 3 months.
the significance of glucose intolerance in the pathogenesis of idiopathic axonal polyneuropathy

Conditions: Idiopathic Axonal Polyneuropathy; Abnormal OGTT

Summary: the purpose of this study is to determine whether impaired glucose handling (abnormality in the way the body processes blood sugar) can cause a neuropathy (damage to the nerves).

neuropathy of undetermined etiology is a common disease that usually starts at the sixth to seventh decades. it can cause significant pain and disability. previous studies have demonstrated increased prevalence of abnormal glucose handling, when these patients were tested with oral glucose tolerance test (ogtt). on the other hand, many of the neuropathy patients suffer from pain and depression and obesity; and abnormal ogtt in these patients may be the result of these factors. we assume that if abnormal handling of blood sugar is the cause of neuropathy, these patients may have evidence of damage to other organs (like eyes and kidneys) as a result of abnormal blood sugar. in a pilot study, we will determine the incidence of subtle damage to kidneys, eyes and also look for other factors associated with abnormal glucose handling in patients with neuropathy and abnormal ogtt and compare it to age matched controls with normal ogtt.

Eligibility criteria:
inclusion criteria: inclusion criteria (for the subjects) will include peripheral neuropathy, age more than 50 years, and a negative workup for neuropathy (aside from an abnormal ogtt). age matched controls will have no history of diabetes or baseline retinal disease . a workup to rule out other causes of peripheral neuropathy, and an ogtt, will be performed prior to participation in the study. exclusion criteria: patients with abnormal ogtt in the diabetic range will not be included.

Keywords: idiopathic axonal polyneuropathy abnormal ogtt
feasibility pilot of bright light in the intensive care unit

Conditions: Circadian Rhythm Sleep Disorder, Unspecified

Summary: to evaluate the feasibility of providing daytime bright light in the icu in a pilot randomized controlled trial.

to evaluate the feasibility of providing daytime bright light in the icu in a pilot randomized controlled trial. feasibility will be assessed via the following metrics: daytime bright light is acceptable and tolerable to patients and has high fidelity and sustainability as an intervention.

Eligibility criteria:
inclusion criteria: 1. hospital admission ≤30 hours at noon on enrollment day 2. expected to say in the medical intensive care unit ≥24 hours after enrollment 3. age ≥50 years 4. history of hypertension based on chart review and presence of 1 or more home blood pressure medications 5. able to understand english exclusion criteria: 1. at significant risk for pre-existing circadian abnormalities: * severe chronic brain injury (injury greater than 30 days ago resulting in the inability to live independently) or acute brain injury of any severity (injury less than 30 days ago including acute intracranial bleed, traumatic brain injury, central nervous system infection, tumor) * documented circadian disorder (\<1% population) or blind/disease of the optic nerve * current history of substance abuse including alcohol (use in last 30 days) * current or recent (last 1 year) shiftwork 2. home medications include: melatonin, melatonin agonist 3. transferred from an outside hospital, long-term care, rehabilitation, or acute care facility 4. history of bipolar disease (bright light therapy possibly unsafe in this population). 5. paralyzed (due to injury, disease or medications) 6. diagnosed with hepatic encephalopathy in the setting of end-stage liver disease 7. homeless

Keywords: circadian misalignment entrainment zeitgeber bright light critical illness
study of the efficacy and safety of pregabalin compared to placebo for treatment of post-surgical pain from hysterectomy

Conditions: Pain, Postoperative

Summary: to assess the efficacy of pregabalin compared to placebo on pain following hysterectomy , measured using subject reported assessments of pain.


Eligibility criteria:
inclusion criteria: * the subject will have elective total abdominal hysterectomy using a transverse incision with or without bilateral salpingo-oophorectomy. the total hysterectomy may, however, be cervix-sparing. * the subject is expected to remain at the hospital (or intermediate care facility) for a minimum of 2 days following surgery. * the subject's preoperative health is graded as the american society of anesthesiologist p1 to p2. exclusion criteria: * subjects having vaginal hysterectomy (whether laparoscopically assisted or not) * subjects having additional procedures (such as those involving the bladder) at the same time as the total abdominal hysterectomy * the use of nerve block, spinal anesthesia or epidural anesthesia for post-surgical pain control * subjects who have been using any opioid medications 2 weeks or more continuously within 3 months prior to the screening visit. * the subject has taken any nsaid or any analgesic other than acetaminophen within 3 days prior to surgery or is unwilling to abstain from nsaids or other analgesics, except as specified in the protocol, during the study. (subjects taking \<325 mg per day of aspirin at a stable dose for at least 30 days before the first dose of study medication will be allowed to continue their aspirin regimen for the duration of the study).

Keywords: pain after hysterectomy amount of opioids used
study of orl-1b in patients with biotinidase deficiency

Conditions: Biotinidase Deficiency

Summary: an open-label, single-arm, phase 2 study of biotin in patients with biotinidase deficiency.


Eligibility criteria:
inclusion criteria: * diagnosis of biotinidase deficiency. * less than 18 years old. exclusion criteria: * diagnosis of any other disease that is not a manifestation of biotinidase deficiency.
qist collaborative - arthroplasty research cohort (arc) study

Conditions: Hip Arthritis; Knee Arthritis

Summary: the arc study is a national observational cohort study to investigate patient reported and clinical outcomes after hip and knee replacements. the study has the following objectives: 1. to evaluate outcomes following hip and knee replacements. 2. to determine risk factors for adverse outcomes in primary hip and knee replacements. 3. to identify targets for future research and intervention in patients undergoing primary hip and knee replacements 4. to provide a resource from which to identify potential participants for future clinical trials, and to use data collected in the arc study as comparison or control data for trial participants who have been randomised to receive one or more interventions. participants are recruited and consented online. patients are invited to participate by collaborating surgical teams nationally in outpatient clinics at the time of being added to a waiting list, in addition to an advertising campaign to recruit patients. they are directed to an online portal where they will be able to review further information. consent and data collection is completed electronically through patients entering data online. baseline demographics and characteristics are recorded, including details of socio-demographics, lifestyle, health status and patient reported outcome measures (proms). patients then undergo hip/knee replacement and postoperative rehabilitation according to the standard care and protocols of the hospital and the preferences of their treating surgeon. follow-up data, including proms, is collected via online questionnaires up to two years following surgery. the study will ultimately also enable multiple trials to be embedded within the cohort study, using a 'trials within cohorts' (twics) methodology.


Eligibility criteria:
inclusion criteria: participants must meet all of the inclusion criteria: 1. uk resident 2. able to read and understand documentation and questionnaires in english language 3. undergoing elective primary hip or knee arthroplasty (thr, tkr or ukr) 4. age 18 years or over 5. provides the necessary consents relating to data collection and use of study data, data linkage, future research and invitation to involvement in future trials exclusion criteria: provided a participant meets all of the inclusion criteria, there are no exclusion criteria for the cohort study.

Keywords: hip replacement knee replacement
management of bone defects around the elbow

Conditions: Tumor; Fracture; Cancer

Summary: background: bone defects of the distal humerus require complex reconstructions, for which standard prostheses may be insufficient. the researchers therefore investigated the clinical and radiological outcome of elbow reconstructions by megaprostheses.

type of prosthesis: stryker humerus-hmrs

Eligibility criteria:
inclusion criteria: * hmrs of the elbow, distal humerus or total humerus exclusion criteria: * unwillingness to participate

Keywords: survival function infection revision loosening
ear acupuncture for neuropathic pain

Conditions: Neuropathic Pain

Summary: the purpose of this study is to gather information on the effectiveness of auricular acupuncture (i.e., the placement of acupuncture needles in specific points on the ear) in reducing pain and improving quality of life among patients experiencing neuropathic pain in the acute inpatient rehabilitation setting.


Eligibility criteria:
inclusion criteria: * patients who have acute or chronic neuropathic pain of any etiology (traumatic, non-traumatic, central, peripheral, and mixed cases). * ability to provide informed consent. * ability to speak english and complete all aspects of this trial. * at least 18 years of age. * patients will have stable neuropathic pain medication dosing for 3 days prior to enrollment to include gabapentin, pre-gabalin, tcas, duloxetine, carbamazepine, oxcarbazepine, and venlafaxine). exclusion criteria: * patients with platelet count \<50,000 or known bleeding disorder. * patients in a severe immunocompromised state. * pregnant women. all patients who meet the criteria will have their medical records reviewed to ensure they are not pregnant. * allergy to gold. * use of non-fda approved herbal supplements. their effect on enhancing or blunting effect of acupuncture is not known. patients using medical marijuana with an approved prescription from a state issuing such prescriptions will not be excluded. * current infection of the skin or cartilage of the ear. * patients already using adjuvant modalities such as chiropractic, massage, yoga, tai chi, massage will not be excluded, but those who add in these modalities during the course of the intervention and observation period will be excluded. * patients not anticipated to stay for a minimum of 7 days after enrollment. * patient without mental capacity to participate in the consent process and the questionnaire responses. * fear of needles or no interest in acupuncture.
artificial intelligence, and e-health literacy in fibromyalgia

Conditions: Fibromyalgia Syndrome; Healthy Controls Group - Age and Sex-matched

Summary: this cross-sectional observational study aimed to assess electronic health literacy and artificial intelligence literacy among individuals diagnosed with fibromyalgia syndrome, with particular focus on artificial intelligence literacy. although general health literacy has been investigated in this patient population, digital and artificial intelligence-related competencies have not been sufficiently studied. the research included 106 individuals diagnosed with fibromyalgia syndrome and 106 age- and sex-matched healthy volunteers, recruited between december 2024 and may 2025. all participants completed a series of standardized questionnaires, including the revised fibromyalgia impact questionnaire, the beck depression inventory, the beck anxiety inventory, the electronic health literacy scale, and the artificial intelligence literacy scale. the study explored demographic, clinical, and psychological factors associated with digital and artificial intelligence literacy levels among both patient and control groups.


Eligibility criteria:
inclusion criteria: age between 18 and 50 years diagnosis of fibromyalgia syndrome according to 2016 american college of rheumatology criteria (for patient group) adequate cognitive function literacy willingness to participate and provide informed consent for control group: healthy individuals matched by age and sex, with no reported health issues exclusion criteria: cognitive impairment preventing questionnaire completion illiteracy presence of severe comorbidities or neurological/psychiatric disorders that may affect participation refusal or inability to provide informed consent

Keywords: fibromyalgia syndrome artificial intelligence literacy electronic health literacy revised fibromyalgia impact questionnaire beck depression inventory beck anxiety inventory
reintegration: the role of spouse telephone battlemind pilot study

Conditions: Military Spouses; Support Groups; Stress Disorders; Combat Disorders

Summary: this study will expand the department of defense (dod) one time, face-to-face post deployment battlemind training for spouses of operation enduring freedom/operation iraqi freedom (oef/oif) guard/reserve service members into year-long, telephone groups focusing on education, skills building and support. the goal is to build spouses' resilience to cope with reintegration, help them serve as a support system for returning service members, and ease the transition for families post-deployment.


Eligibility criteria:
inclusion criteria: 1. have a spouse who participated in oef/oif and is at least 1 month post-deployment; 2. if not married, must have lived as married for at least one year; 3. live with the service member when not deployed; 4. have been a spouse/significant other throughout the service member's deployment period; 5. and have a telephone. exclusion criteria: 1. current diagnosis of schizophrenia or other major mental illness; 2. auditory impairment that would make telephone use difficult; or 3. service member refusal of assent for spouse to participate.

Keywords: spouses social support reintegration families military post deployment oef/oif
stress management to support women's health

Conditions: Hypertension; Stress; Cardiovascular Diseases

Summary: the purpose of this study is to evaluate a mindfulness-based cognitive therapy intervention delivered over the phone (mbct-t) for women with prehypertension. mbct-t is an evidence-based program that teaches meditation practices and cognitive strategies to reduce stress and negative emotions. it targets psychosocial risk factors that disproportionately affect women, including rumination (i.e., negative thinking) and low social support. investigators plan to translate the established mbct-t program into spanish, conduct focus groups to inform cultural adaptations that may be needed for latina women, and run a pilot randomized controlled trial to test the feasibility, acceptability and effects of mbct-t on blood pressure and perceived stress in diverse women with prehypertension.

chronic stress is associated with the development of hypertension and cardiovascular disease. reducing stress may be a useful prevention strategy for people at elevated risk of hypertension, including those with prehypertension. women report different types of stress than men and may need tailored stress management programs.

Eligibility criteria:
inclusion criteria: * female * english- or spanish-speaking * a current patient of nyu/bellevue hospital center (bhc) for the nyu study site or san ysidro health center (syhc) for the ucsd study site * bp measurement in prehypertensive range (sbp 120-139 mmhg or dbp 80-89 mmhg) recorded in ehr within past 6 months and bp in prehypertensive range at screening * willing to provide informed consent and comply with all aspects of the protocol * willing to be audio-taped exclusion criteria: * current use of antihypertensive medication * clinically significant depressive symptoms (phq-8 ≥10) * significant cognitive impairment, in the ehr or apparent during screening * history of current diagnosis of schizophrenia or other psychotic disorders * current participation in another clinical trial

Keywords: mindfulness-based cognitive therapy meditation
qualitative exploration of head & neck cancer patient reported experience of radiotherapy

Conditions: Oncology; Head and Neck Cancer; Anxiety

Summary: the study aims to explore the experience of patients with head and neck cancer, who are preparing for and/or completed radiotherapy treatment.

this is a non-interventional study using interviews to explore head and neck cancer patients' experience of preparing for and completing radiotherapy utilising an immobilisation mask. the study will be conducted in 2 stages: the first stage is item generation. approximately 20 interviews will be conducted with head and neck cancer patients who have completed or partially completed radiotherapy. the interviews will capture their experiences and views pertaining to mould making, scans and radiotherapy, reported associated fear of restriction, suffocation, loss of control and fear of public embarrassment during treatment. the data from the interviews will be used to develop potential items for a screening tool for identification of those patients likely to experience anxiety and claustrophobia before they start their treatment. the second stage is cognitive interviews. approximately 5 patients included in stage i will be invited to take part in a further interview to review the themes and potential questionnaire items identified from interviews.

Eligibility criteria:
inclusion criteria: * aged over 18 (no upper age limit) * completed or partially completed radiotherapy treatment utilising a mask ≥ 6 weeks previous to study entry exclusion criteria: * unable to understand and communicate in the english language * unable to provide written informed consent

Keywords: patient experience claustrophobia radiotherapy radiotherapy moulds radiotherapy masks
septal positioning of ventricular implanted cardioverter defibrillator (icd) leads

Conditions: Ventricular Tachycardia; Ventricular Fibrillation

Summary: this clinical trial is a multi center, prospective, randomized, parallel study designed to compare septal to apical icd lead placement.

the primary objective of this clinical investigation is to demonstrate that septal positioning of the right ventricular defibrillation lead is not inferior to the apical positioning in terms of safety and efficacy in a population of icd recipients.

Eligibility criteria:
inclusion criteria: * age \>=18 years * signed written informed consent * approved indication for implantation of icd / crt-d device exclusion criteria: * preexisting transvenous rv pacemaker or icd leads * pacemaker dependency without sufficient intrinsic rhythm (≤ 30min-1) * hypertrophic obstructive cardiomyopathy * presence of intra-aortic balloon pump * inotropic drug (not digitalis) necessary for hemodynamic support * inability to perform vf induction testing due to anticipated high risk * condition likely to limit cooperation * unable to give informed consent * pregnancy or planned pregnancy in the next 6 months * patients with planned cardiac surgery within the next 3 months following randomization * patient is currently participating in a clinical investigation that includes an active treatment arm. * acute myocardial infarction within the previous 4 weeks.
laura mitchell's relaxation versus papworth exercise in ashmatic patient

Conditions: Asthmatic

Summary: asthma is a lung disease that is characterized by airway obstruction that is reversible either spontaneously or with treatment, airway inflammation, and increase airway responsiveness to a variety of stimuli. a wide variety of pharmacological interventions are available nowadays. apart from that, different physical therapy techniques increase cardiorespiratory fitness and inspiratory pressure and limit symptoms and restrict medication use. physical therapy techniques that can be beneficial for an asthmatic patient include breathing exercises (be), inspiratory muscle training (imt), physical therapy training (pht), and airway clearance (ac). laura mitchell's relaxation technique and papworth exercise are advised as an effective nonpharmacological intervention leading to the improvement of symptoms in asthmatic patients. in this study the effects of laura mitchell's relaxation technique and papworth exercise on dyspnea, fatigue, and sleep quality in asthmatic patients will be compared. a randomized clinical trial will be conducted at laeeque rafiq hospital, lar. convenient sampling technique will be applied on-patients according to the inclusion criteria. patients will be allocated through simple random sampling into group a \& group b. group a will be treated with laura mitchell's relaxation technique and group b will be treated with papworth exercise. treatment evaluation will be done after 2 weeks of intervention through pulse oximeter, asthma fatigue scale, dyspnea 12 scale and pittsburgh sleep quality index. data will be analyzed using spss software version 25. after assessing normality of data by shapiro-wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.


Eligibility criteria:
inclusion criteria: * age group of 20-45 years * both male and females * patients diagnosed with asthma according to gina guidelines, who had not smoked for at least one year exclusion criteria: * patients with the history of acute asthmatic attack in last one month. * hemodynamically unstable. * cough and active hemoptysis