Kornimate/medical-research-clean huggingface dataset:
effect of an amino acids and flavonoids containing fsmp on chemotherapy toxicity, nutritional status and quality of life in breast cancer patients

Conditions: Breast Cancer

Summary: the goal of this clinical trial is to compare the effect of a food for special medical purposes (fsmp) mainly containing amino acids and flavonoids in combination with nutritional counseling, versus nutritional counseling alone, on chemotherapy toxicity, nutritional status and quality of life in patients with breast cancer. the main questions it aims to answer are: * can this dietary supplementation affect the nutritional status of breast cancer patients? * can this dietary supplementation have any beneficial effect on chemotoxicity? participants will be asked to undergo nutritional counseling and to take the study product every day for 12 weeks. researchers will compare a similar group of participants only receiving the nutritional counseling to see if any difference occurs.

participants will be selected at the first oncological visit at the outpatient clinics or the department of medical oncology of the irccs policlinico san matteo of pavia. the doctor, evaluated the inclusion and exclusion criteria, will propose patient to participate in the study and, after obtaining informed consent, will proceed with enrollment. on the first day of chemotherapy, participants will undergo an oncological and nutritional examination, with collection of anthropometric data, assessment of body composition, assessment of quality of life through special validated questionnaires, blood sampling for blood chemistry tests and urine collection. participants in the treated group will receive a supply of the fsmp to take home. at check-up visits, the participant's nutritional status and any adverse events will be assessed, other than adherence to treatment by delivery of empty product boxes and chemotherapy compliance. blood chemistry tests will be repeated at 6 weeks after the first chemotherapy cycle and 3 weeks after the last chemotherapy cycle (follow-up period).

Eligibility criteria:
inclusion criteria: * diagnosis of non-metastatic ductal breast cancer * post-menopausal women * chemotherapy with doxorubicin or epirubicin, with or without cyclophosphamide, scheduled as adjuvant or neo-adjuvant * written informed consent * independent oral feeding * must be able to carry out periodic visits exclusion criteria: * artificial feeding * eastern cooperative oncology group (ecog) performance status \>2 * impossibility to take the foreseen measurements * other tumor pathologies * previous therapy with doxorubicin or epirubicin * ongoing treatment with molecular targeted therapies * previous chronic renal, hepatic or cardiac insufficiency * history of mental disorders * known allergies or intolerances to any study product ingredient * participation in other interventional clinical trials in the past three months

Keywords: breast cancer flavonoids aminoacids nutrition
the effects of dual task training with different task priorities on physical performance and cognitive status in patients with parkinson's disease

Conditions: Parkinson&#39;s Disease (PD); Dual-task; Balance; Walking; Mobility; Cognition

Summary: this study was planned to investigate and compare the effects of variable and fixed priority dual task training on balance, walking skills, mobility and cognition in patients with parkinson's disease.


Eligibility criteria:
inclusion criteria: * having agreed to participate in the research after being given detailed information about the research. * having been diagnosed with parkinson's disease by a specialist neurologist according to the uk brain bank criteria * being in stage 1-3 according to hoehn \& yahr * being 40 years of age or older exclusion criteria: * having a neurological condition other than parkinson's disease * cognitive impairment * have undergone deep brain stimulation surgery * having a visual, auditory or perceptual problem * having any orthopedic, rheumatological or other disease that may affect walking and balance.
trends of morbidity and mortality among thai hiv-infected and hiv-uninfected patients: a five-year prospective cohort study

Conditions: HIV Infection; Healthy

Summary: 1. to describe the morbidity and clinical characteristics among hiv-infected patients and hiv-uninfected patients. 2. to identify the risk factors for the complication or morbidity among hiv-infected patients and hiv-uninfected patients. 3. to describe the mortality among hiv-infected patients and hiv-uninfected patients. 4. to identify the risk factors for the cause of death among hiv-infected and hiv-uninfected patients.

the information obtained from this study would be very important in planning future holistic care of hiv-infected patients in our institutes as well as in national policy. results from the study could be used to develop proper long-term management guidelines for people living with hiv (plhiv) in thailand targeted at preventable conditions such as metabolic diseases and certain cancers.

Eligibility criteria:
inclusion criteria: hiv-infected patients group * hiv positive * 30 years of age or older, both male and female * thai nationality * written research informed consent hiv-uninfected patients group * hiv un-infected * 30 years of age or older, both male and female * thai nationality * written research informed consent exclusion criteria: hiv-infected patients group * systolic bp ≥ 130 or diastolic bp ≥ 85mm hg or on the treatment * fasting blood sugar \> 126 mg/dl or on the treatment * proteinuria * creatinine \> 1.5 mg/dl * recent hospitalization * patient who are having mental disease hiv-uninfected patients group * systolic bp ≥ 130 or diastolic bp ≥ 85mm hg or on the treatment * fasting blood sugar \> 126 mg/dl or on the treatment * proteinuria * creatinine \> 1.5 mg/dl * recent hospitalization * patient who are having mental disease

Keywords: morbidity mortality hiv-infected patients prospective cohort study highly active antiretroviral therapy (haart) opportunistic infections non hiv-related illness cardiovascular disease (cvd) hiv negative patients thai hiv-infected patients
michigan screening and intervention for glaucoma and eye health through telemedicine (sight) 2

Conditions: Eye Diseases; Visual Impairment; Glaucoma

Summary: to compare eye disease detection rates at a federally qualified health center between a technology-enhanced protocol and standard optometric clinical examination for three of the leading causes of blindness: glaucoma, diabetic retinopathy, and visually significant cataract.

see study protocol.

Eligibility criteria:
inclusion criteria: speak english or spanish exclusion criteria: 1) significant eye pain (2) sudden decrease in vision within one week (3) binocular diplopia (4) cognitive impairment (5) pregnancy, or (6) previously declined participation

Keywords: eye disease screening glaucoma detection
identification of serum and/or plasma biomarkers for the diagnosis prognosis and/or prediction of invasive mycosis in neutropenic patients

Conditions: Neutropenic Patients

Summary: the aim of the present work is to study the protein expressions profiles of neutropenic patients (with a high risk of invasive mycosis) who developed - versus who did not develop invasive mycosis (principally aspergillosis and candidosis) in order to identify biomarkers for the diagnosis, prognosis and /or prediction of invasive mycosis.


Eligibility criteria:
inclusion criteria: * - patients with malignant haemopathy who received chemotherapy likely to lead to severe neutropenia (pn\<500/mm3) for a foreseeable period of 10 days. * patients aged 14 years or older (no upper age limit) * patients with malignant haemopathy who received an autologous marrow graft. * patients with severe idiopathic medullar aplasia (pn\<500/mm3) who need to be hospitalised for at least 10 days consecutively (with or without immunosuppressant treatment). * patients who have provided written informed consent to participate in this study. exclusion criteria: * patients who received an allograft of marrow or hematopoietic stem cell transplant (given that these patients carry a risk of aspergillosis, which in most cases appears after medullar recovery, they will not be included in the study). * patients who received an autologous hematopoietic stem cell transplant (given that the duration of the neutropenia is often less than 10 days). * patients who do not meet the inclusion criteria * persons not covered by the national health insurance agency
relevance of trichoscopy in differential diagnosis of focal non-cicatricial alopecia in children

Conditions: Focal Non-cicatricial Alopecia

Summary: alopecia is a common, distressing condition that is sometimes difficult to diagnose and treat. losing hair is not usually health threatening; it can scar a young child's vulnerable self-esteem by causing immense psychological and emotional stress, not only to the patient, but also to the concerned parents and siblings; so the cause of hair loss should be diagnosed and treated early to overcome the resulting problems.

the majority of alopecia in children is presented as patchy alopecia, which is most commonly diagnosed as alopecia areata. however, other causes of patchy alopecia such as tinea capitis, trichotillomania, temporal triangular alopecia (tta), nevus sebaceous and aplasia cutis congenita (acc) can be easily missed. trichoscopy (hair and scalp dermoscopy) is a non-invasive diagnostic tool that allows the recognition of morphologic structures not visible by the naked eye. trichoscopy allows visualization of hair shafts at high magnification and performing measurements, such as hair shaft thickness, without the need of removing hair for diagnostic purposes. it also allows in vivo visualization of the epidermal portion of hair follicles and perifollicular epidermis. the advantages of trichoscopy in evaluating hair loss in children are numerous, as it is a fast in-office technique , non-invasive, inexpensive, and painless , and therefore it will be accepted by children and their parents. tinea capitis and alopecia areata are considered to be the most common causes of hairless patches of the scalp in pediatrics. tinea capitis especially non-scaly type may have the same clinical appearance of alopecia areata, so trichoscopy has recently become a useful diagnostic tool for alopecia areata and tinea capitis, especially in doubtful cases as lab investigations like fungal culture or biopsy may take several weeks.

Eligibility criteria:
inclusion criteria: -age from 3-18 years of both sexes with focal non-cicatricial alopecia.(1-5 patches of alopecia) exclusion criteria: 1. patients who will not consent. 2. uncooperative children. 3. patients with active secondary bacterial infection in the alopecic patch. 4. patients with any concomitant dermatological diseases. 5. history of using any topical(1 month) or systemic treatment (3 month) for tinea capitis or alopecia areata prior to the study, 6. cicatricial alopecia.
urodynamics and music

Conditions: Incontinence, Urinary

Summary: today music acts as an analgesic and anxiolytic in a safe, cheap and simple way. several trials have confirmed its potential administration and benefits in urology practice. we aimed to assess the influence of music therapy on perceived anxiety and pain during outpatient urodynamic study (uds) using the visual analog scale (vas) and the state-trait anxiety inventory (stai) in a prospective, randomized fashion

urodynamic study (uds) is often used to help urologists to evaluate the functions of bladder and urethra in outpatient clinic.1 although a uds is a reliable tool for accurate diagnosis, the process itself can be accompanied by discomfort and pain as it includes the positioning the catheters urethral and rectally, and the bladder filling. reports of having such invasive outpatient process whilst awake may demonstrate pain and disquiet that result in incomplete examinations and patient noncompliance2,3. various pharmacologic options including lidocaine gel and catheter tip lubrication for urethral catheterization were used to relieve pain and anxiety during uds. besides, there are some non-pharmalogical methods such as patient education, heating pad, music, distraction and relaxation4-6. music has been considered complementary treatment modality as cheap, safe and effective. in various urological procedures including cystoscopy, transrectal prostate biopsy and extracorporeal shock wave lithotripsy (eswl) music has been proven helpful on pain and anxiety levels 7-10. however, current literature presents limited and controversial data evaluating the influence of music on pain and anxiety perspective of the patient during uds. we, therefore, aimed to assess the effect of music on patient satisfaction in a analgesic and anxiolytic way during uds.

Eligibility criteria:
inclusion criteria: - exclusion criteria: exclusion criteria included paraplegia, hearing impairment, taking any analgesic or anxiolytic drug to suppress the symptoms of anxiety until 24 hours prior to uds, inability to understand or fulfill commands during uds.

Keywords: music
factors affecting rehabilitation time for postoperative complications among breast cancer patients

Conditions: Breast Cancer

Summary: breast cancer patients who had undergone surgery, chemotherapy and radiotherapy suffered from complications, including shoulder stiffness, lymphedema and scar contracture. these symptoms impaired one's adl function. rehabilitation may relieved symptoms. however, it is difficult to estimate how long one should receive rehabilitation. the study is trying to establish a machine-learning based model in order to predict the period of rehabilitation.

breast cancer survivors suffered from complications after surgery, chemotherapy and radiotherapy. these complications include shoulder stiffness, upper limb lymphedema and scar contracture, which altogether impaired one's adl function. rehabilitation had been approved to relieved these symptoms effectively. however, many factor may interfere the patient's participation of rehabilitation, making it difficult to estimate how long one should receive rehabilitation. in taiwan, national health insurance provides affordable, accessible and unlimited health care and medical service for all citizens, eliminating many social-economic barriers. thus we are trying to establish a machine-learning based model in order to predict the period of rehabilitation. our study is a retrospective case-control study. the objectives are breast cancer survivors who attended post-surgery rehabilitation at least once for complications. the following data are collected from e-his system: 1. patient characteristic: age, unilateral or bilateral cancer. 2. surgery type: total, partial or simple mastectomy. 3. lymphatic surgery: alnd and slnb 4. other surgical procedure: breast reconstruction, flap surgery. 5. combined therapy: chemotherapy, radiotherapy or hormone therapy. 6. complications: shoulder stiffness, lymphedema, scar contracture (ex., axillary web syndrome), neurological deficit. 7. the first between operation and first time of rehabilitation. the primary outcome is the total rehabilitation time, which will be divided as short term (less than 360 min) and long time (more than 360 min). the data will be processed using weka and machine learning algorithms, including logistic regression, supportive vector machine, k-nearest neighbors, decision tree and random forest.

Eligibility criteria:
inclusion criteria: * patients who received operation for breast cancer * attended rehabilitation at least once for breast cancer related complications exclusion criteria: * patients who received rehabilitation for other reasons rather than surgical complications * patients who are transfered to other hospital for rehabilitation

Keywords: rehabilitation breast cancer
role of bumetanide in treatment of autism

Conditions: Autism

Summary: role of bumetanide in autism

role of bumetanide in treatment of autism spectrum disorder in children

Eligibility criteria:
inclusion criteria: 1. all patients with asd diagnosed by cars rating scale⩾30. 2. age of patients range between (3-12) years. exclusion criteria: * patients with asd associated with neurological antecedents (including epilepsies and febrile seizures), hepatic, renal dysfunction or electrocardiogram abnormalities and syndromatic children(rett).
dna methylation and hydroxymethylation levels in patients with coronary heart disease

Conditions: Coronary Heart Disease

Summary: the purpose of this trial is to investigate the relationship between dna methylation and hydroxymethylation and the expression of dnmts, tet family gene and the degree of coronary heart disease.

1. to determine the levels of dna methylation and hydroxymethylation with coronary heart disease. 2. to investigate the relationship between dna methylation and hydroxymethylation and the degree of coronary atherosclerosis.

Eligibility criteria:
inclusion criteria: male and female. patients older than 65 years old who are willing to participate in the study. chd patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms. control group was defined as people with negative findings in coronary angiograms. exclusion criteria: patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases, or any other malignancy. patients with a history of cardiomyopathy. pregnant women. severe hepatic dysfunction or end-stage renal failure. uncontrolled hypertension.

Keywords: methylation hydroxymethylation atherosclerosis coronary heart disease
prevalence and severity of venous thromboembolism in a general population during the covid-19 pandemic

Conditions: COVID-19; Venous Thromboembolism; Pulmonary Embolism; Deep Vein Thrombosis; SARS-CoV 2

Summary: the purpose of this study is to investigate the prevalence of venous thromboembolism in a regional health care system (region östergötland, sweden) before and during the sars-cov-2 pandemic. in a retrospective observational study, we will review patient data, diagnostic data and treatment data over a three-month period since the onset of the sars-cov-2 pandemic. this data will be compared with data from the corresponding time frame during the years 2015 to 2019.

in the current sars-cov-2 pandemic there is a concern about an increased risk of venous thromboembolism (vte) concurrent with the infection, including both pulmonary embolism (pe) and deep venous thrombosis (dvt) (klok et al. 2020; cui et al. 2020; helms et al. 2020; leonard-lorant et al. 2020; poissy et al. 2020). international guidelines now recommend prophylactic anticoagulation for all hospitalized patients with a sars-cov-2 infection in the absence of any contraindication (thachil et al. 2020). the majority of the studies on vte in sars-cov-2 infections have been carried out in the icu and show prevalence of vte of between 20 and 30%.(klok et al. 2020; cui et al. 2020; helms et al. 2020). this is a clear increase compared to the less than 10 % prevalence seen in other icu patients (muscedere, heyland, and cook 2007; deborah cook et al. 2005; d. cook et al. 2000). however, a single center study on consecutive icu patients with severe sepsis showed a prevalence of vte of 37% (kaplan et al. 2015) and another recent publication of patients with severe influenza a/h1n1 infection had a prevalence of vte of 44% (obi et al. 2019). this raises the question whether the increase in vte seen in recent publications of sars-cov-2 infections is the result of the specific pathophysiology of the virus itself or the subsequent sepsis with multiorgan failure seen in most complicated and severe cases. the former would have large implications for patients treated outside the icu and possibly outside hospitals (thachil et al. 2020). the aim of this study will be to investigate the prevalence of vte in a regional healthcare system prior to, and during the sars-cov-2 pandemic and the differences between icu, hospitalized and outpatient cohorts.

Eligibility criteria:
inclusion criteria: * any patient that has done a computer tomography angiography of the lungs between 1:st of march and 31:st of may each year from 2015 to 2020 * any patient that has done a ultrasound of the legs between 1:st of march and 31:st of may each year from 2015 to 2020 * any patient with a new diagnosis of pulmonary embolism or deep venous thrombosis between 1:st of march and 31:st of may each year from 2015 to 2020 exclusion criteria: * incomplete diagnostic examination * follow-up examination of know acute vte * primary investigation done outside the healthcare system * patient \<18 years of age
the efficacy of suprascapular nerve radiofrequency and intra-articular steroid injection in frozen shoulder treatment

Conditions: Frozen Shoulder; Radiofrequency Ablation Treatment; Intra-articular Injection

Summary: the aim of this clinical study is to compare the effectiveness of suprascapular nerve pulsed radiofrequency and intra-articular steroid injection in patients with frozen shoulder (adhesive capsulitis). the main questions it aims to answer are: 1. what is the effectiveness of intra-articular steroid injection in frozen shoulder? 2. what is the effectiveness of suprascapular nerve radiofrequency in frozen shoulder? 3. should these two methods be used together in frozen shoulder?


Eligibility criteria:
inclusion criteria: * unilateral side involvement. * ≥50% loss of passive rom (external rotation or abduction) in the glenohumeral joint comparing to the unaffected side. * duration of symptoms ≥3 months. * age≥ 20year old. * patients with vas ≥4 before the procedure exclusion criteria: * ever received manipulation of the affected shoulder with/without anesthesia. systemic disease, severe degeneration, or trauma involving the shoulder. (ie, rheumatoid arthritis, osteoarthritis, history of injury to the labrum or articular cartilage or malignancies in the shoulder region, etc.) * neurologic diseases such as stroke or peripheral nerve neuropathy that have already affect the activity of shoulder. * pain or disorders of the cervical spine, elbow, wrist, or hand. * a history of drug allergy to local or corticosteroids. * pregnancy or lactation. * received corticosteroids, or hyaluronic acid intra-articular injection into the affected shoulder during the preceding 4 weeks. * patients with vas \<4 before the procedure

Keywords: frozen shoulder radiofrequency ablation treatment intra-articular injection
effect of insulin detemir on blood glucose control in subjects with type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in china. this trial aims for a comparison of the effect on glycemic control in subjects with type 2 diabetes of insulin detemir or nph-insulin given once daily at bedtime as add-on to oral anti-diabetic drug(s).


Eligibility criteria:
inclusion criteria: * type 2 diabetes * hba1c greater than 7.5% and less than or equal to 11.0% * currently on any oral antidiabetic drug (oad) more than or equal to 3 months exclusion criteria: * previous acute treatment with insulin for more than 7 days. * treatment with oad(s) which does not adhere to the approval labeling. * proliferate retinopathy or maculopathy that has required acute treatment within the last year. * known hypoglycaemia unawareness or recurrent major hypoglycaemia, that may interfere with study participation as judged by the investigator.