Kornimate/medical-research-clean huggingface dataset:
react against stroke

Conditions: Stroke

Summary: acute stroke management represents a true medical emergency that requires prompt diagnosis and urgent treatment. in a previous exhaustive cohort study conducted in the rhône region, france (avc69) the investigators observed that only a small percentage of patients could access to thrombolysis in time. in this cohort of 1306 patients treated in one of the emergency department of the rhone region for a suspected stroke, 84% of patients reached hospital through an emergency department instead of going directly to a stroke unit. among those patients, only 8% were finally thrombolysed, because of extended management times.. our hypothesis was that public awareness campaign designed to improve public's knowledge and skills would consequently reduce prehospital time and favour call to prehospital emergency medical services (ems). the investigators will conduct an awareness campaign aimed at the general population, using different communication media, the content will be developed based on the results of a qualitative study with focus groups (quali-avc), and using a diffusion plan established with communications professionals. to assess the effects of this campaign, a comparative quasi-experimental before-after study will be conducted. a control region where no awareness stroke program has been set up has been selected, data will be collected in the two regions. the assessment of the impact of the campaign will focus on the comparison of the evolution of indicators between these two regions. three assessment time will be provided: before starting the program, at 3 months and at the end of the program.


Eligibility criteria:
inclusion criteria: - all adult patients calling ems for suspected stroke identified by at least one symptom among face paralysis, limb paralysis or speech disorder (fast positive) exclusion criteria: - age below 18

Keywords: stroke public awareness campaign call to ems
developing effectiveness evaluation and therapeutic programs of rehabilitation

Conditions: Healthy Volunteers; Motor Deficits; Dysphagia

Summary: using robotics, sensors, and semg to develop clinic-oriented quantitative effectiveness evaluation and individualized programs of rehabilitation

using robotics, sensors, semg or other methods to develop clinic-oriented quantitative effectiveness evaluation and individualized programs of rehabilitation

Eligibility criteria:
inclusion criteria (for healthy people): * no history of psychological/psychotic problems, no history of important diseases. exclusion criteria (for healthy people): * history of psychological/psychotic problems inclusion criteria (for patients with motor deficits or dysphagia): * patients with motor function impairment such as post stroke hemiplegia. exclusion criteria (for patients with motor deficits or dysphagia): * cognitively or physically unable to cooperate with the examiner to finish the test
does immobilization of the shoulder in external rotation reduce the recurrence rate of shoulder dislocation?

Conditions: Shoulder Dislocation

Summary: dislocation of the glenohumeral joint is the most common traumatic joint dislocation. the usual treatment of first time traumatic anterior dislocation of the shoulder is reduction followed by immobilization in a sling for a period of one to three weeks. the incidence of recurrence is high and age at the time of primary dislocation is the chief prognostic factor in determining the risk of recurrence. there is no agreement according to the effect of immobilization,neither to the length of immobilization time. the bankart lesion with avulsion of the inferior-anterior capsulolabral complex is almost invariably present in patients with anterior shoulder dislocation. recent and ongoing studies by eijii itoi et al,akita university japan, gives evidence of the immobilization with the arm held in external rotation may reduce the risk of subsequent instability by approximating the bankart lesion to the neck of the glenoid giving a more anatomical healing. we have started a prospective randomized study. the patients are assigned to two groups with informed consent. one group are immobilized in internal rotation for 3 weeks and the second group are immobilized in external rotation for 3 weeks. we will compare the rate of relaxation between the groups. because age is the main prognostic factor we use stratified randomization with two age groups: one group of patients aged between 16 and 24 years and one group aged between 25 and 40 years.the time of observation after initial treatment will be 2 years with follow up after 4 and 10 years. eleven hospitals and two primary trauma care centers in norway participate in the study. a subgroup of 50 patients are also planned to be examined with ct and mri.

see earlier protocol in 2005

Eligibility criteria:
inclusion criteria: the patient has a first time traumatic anterior dislocation of the shoulder. the dislocation is verified by x-ray examination. the patient is aged between 16 and 40 years. - exclusion criteria: an osseous defect of the anterior glenoid rim in which the length is at least 20% and the width at least 1/3 of the the length of the anterior bony glenoid rim. a fracture of tuberculum majus which do not fall into place after manually reduction of the dislocated shoulder.(that means more than 1 cm diastase) damage of the axillary nerve or plexus the patient is not able to or willing to participate in the study. -

Keywords: shoulder dislocation anterior traumatic primary first time initial immobilization external rotation
biodiversity interventions for well-being

Conditions: Microbial Colonization; Immune System Diseases; Well-Being, Psychological; Nature, Human

Summary: biodiversity is essential for nature and human well-being. land use has reduced biodiversity in cities, which weakens the functionality of the urban ecosystems and the well-being of citizens. this may also increase the risk of immune-mediated disorders among urban dwellers. in biodiversity interventions for well-being (biwe), microbial biodiversity interventions are performed to increase biodiversity in urban built areas. results from the intervention trials are combined with publicly available land cover and ecological data. these are analyzed from the viewpoint of shifts in ecosystems and human well-being and immune regulation, ecological quality, and urban planning. the investigators set up an intervention study in which urban private yards are rewilded with diverse vegetation and decaying deadwood and plant residuals. the investigators aim to evaluate the effect of rewilding, and yard management practices on commensal microbiome, cortisol levels and well-being and salivary cytokine levels, and gene pathways.

our specific aims are: to assess if rewilding diversifies health-associated skin microbiota and is associated with salivary cytokine levels, gene pathways, cortisol levels and commensal microbiota. assess whether there are patterns in the microbiome associated with the salivary cytokine levels and hair cortisol levels. assess whether rewilding affects health and psychological measures, such as perceived stress scale (pss), warwick-edinburgh mental wellbeing scale (swemws), depression scale (deps) and nature relatedness scale (nr6). the investigators will recruit approximately 42 (21 study subjects per treatment) subjects living in a detached house or terraced house in urban areas and aged between 18-72. the medical exclusion criteria include immunosuppressive medications, immune deficiencies, a disease affecting immune response (e.g., colitis ulcerosa, rheumatoid arthritis, crohn's disease, diabetes), cancer diagnosis within the last year or on-going cancer treatment. other exclusion criteria include incompetency and living outside city area.

Eligibility criteria:
inclusion criteria: * living in a detached or terraced house in urban area exclusion criteria: * immunosuppressive medications * immune deficiencies * a disease affecting immune response (e.g., colitis ulcerosa, rheumatoid arthritis, crohn's disease, diabetes) * cancer diagnosis within the last year or on-going cancer treatment * incompetency * living outside city area.

Keywords: commensal microbiome salivary cytokines planetary health well-being
a registry study on hiv-related lymphoma

Conditions: AIDS Related Lymphoma; HIV Related Lymphoma

Summary: retrospective und prospective registry on hiv-associated lymphoma. data on characteristics, type and toxicity of treatment and outcome of patients with hiv-lymphoma will be collected.

to study characteristics, treatment approaches and outcome of hiv-infected patients with malignant lymphoma in the combination antiretroviral therapy (cart) era. hiv-infected persons diagnosed with non-hodgkin lymphoma or hodgkin lymphoma will be included. the choice of treatment is not specified by the registry study. however, the type of antineoplastic treatment should follow national or international recommendations and guidelines. data will be pseudonymized by the data manager of the treating institution. central data management is located at red cross hospital munich, germany.

Eligibility criteria:
inclusion criteria: * histology or cytology proven non-hodgkin lymphoma or hodgkin lymphoma * hiv-infection at time of lymphoma diagnosis * lymphoma diagnosis since 01.01.2010 * adult patients ≥ 18 years * written informed consent exclusion criteria: * hiv-diagnosis \> 3 months after the diagnosis of malignant lymphoma * non-compliance or lack of opportunity for follow-up (for the prospective part of the study)

Keywords: malignant lymphoma hiv-related lymphoma hiv-associated hodgkin lymphoma
a long term follow up of anterior meshes for recurrent prolapse

Conditions: Genital Diseases, Female; Pelvic Organ Prolapse

Summary: prolapse of the vaginal wall and uterus are common conditions affecting up to 50% of parous women. the socioeconomic, psychological and physical impacts of prolapse are considerable. 11% of women will undergo a surgical repair by the age of 80 years. the commonest compartment affected is the anterior vaginal wall. unfortunately there is a significant rate of recurrent prolapse or a failure of the primary procedure. this has lead to the introduction of new techniques and the use of different materials to augment the repair. mesh augmented repairs aim to reduce the rate of recurrent prolapse. however, the use of synthetic mesh is associated with complications which are not found in non mesh repairs. 10% of women will have a mesh complication of which 70% will require a further surgical procedure to manage the complication. there are extra costs associated with purchasing the mesh, with longer operating times to insert the mesh and managing complications caused by the mesh. balancing the extra risks of mesh surgery against the benefits is probably one of the most contentious issues in urogynaecology at the present time. regulatory authorities in the usa (fda) and uk (mhra) have become increasingly interested in the use of mesh to support the vaginal wall in prolapse surgery due to risks and complications being reported. to date there is little evidence regarding the long term safety and efficacy of anterior mesh repairs. this study aims to rectify this deficiency for perigee.

this will be a consecutive cohort study of patients identified from a surgical database of perigees performed in a single centre. all patients will have had the procedure performed between 2007 and 2011. this will be a single centre study. the principle investigator has both electronic and hand written records of all perigee repairs performed since the introduction of this technique in 2007. the patients will be identified from both the paper and electronic databases and cross referenced. after obtained appropriate ethical approval, patients identified as having a perigee mesh inserted will be asked to attend medway hospital for a full clinical evaluation. they will be sent a letter with an appointment to come to the hospital. they will be asked to complete the pelvic floor distress inventory questionnaire to assess their symptoms. they will have a pelvic examination to determine if they have any mesh erosion and will undergo a pop-q score. this visit will take 1 hour.

Eligibility criteria:
inclusion criteria: * women undergoing a perigee procedure after january 2007 exclusion criteria: * patient having non mesh repairs over the same time scale

Keywords: mesh pelvic organ prolapse
effect of pulmonary rehabilitation program on post hospitalization severe covid- 19 patients

Conditions: Post COVID-19 Condition

Summary: covid-19 infection was discovered to be the major global cause of a serious respiratory illness toward the end of 2019. the majority of covid-19 patients experience mild disease, while about 14% go on to have severe disease and 6% end up in critical condition. an evidence-based standard of therapy called pulmonary rehabilitation includes exercise training, education, and behavior modification to help people with lung illness feel better physically and mentally. the aim of the study to evaluate the effect of pulmonary rehabilitation program on severe post covid19 patients (post hospitalization) regarding pulmonary function tests and dyspnea score.

sars cov-2 infection has caused substantial death, morbidity, and unprecedented strain on the world's healthcare systems . when the illness is minor, it typically takes two weeks from the onset of symptoms till recovery, and when it is severe or critical, it may take three to six weeks. it should be mentioned that approximately 75% to 80% of hospitalized patients will remain there for more than 21 days . after the virus is defeated, covid-19 can have serious aftereffects on the patient, with bilateral pneumonia. as a result, physiotherapy is essential in this pandemic and will play a major role in helping many patients' health. a 20-30% reduction in pulmonary capacity has already been reported in recent studies . although pulmonary rehabilitation has been suggested following severe covid-19, there is a lack of data showing effectiveness on recovery of physical and psychosocial parameters in severe covid-19 patients following hospitalization. the aim of the study is to evaluate the effect of pulmonary rehabilitation program on severe post covid19 patients (post hospitalization) regarding pulmonary function tests and dyspnea score. 50 patients were enrolled in the study post hospitalization due to severe covid 19 infection. dyspnea score, spirometry and 6minute walk test were performed upon discharge. pulmonary rehabilitation program was performed. follow up assessment of the same parameters was done 6 weeks after the program. these results were compared with another 50 patients who were admitted in hospital due to severe covid 19 infection but no pulmonary rehabilitation program was performed to them after hospitalization.

Eligibility criteria:
inclusion criteria: * age range between 50 and 70 years. * severe covid infection. * impaired pulmonary function tests post covid infection. exclusion criteria: * mild or moderate covid infection. * normal pulmonary function tests post covid infection * chronic chest disease * end organ failure (sever heart disease-neurodegenerative disease- sever stroke) * unstable angina, myocardial infarction, angioplasty, heart surgery in the previous 3 months * chronic renal impairments. * epistaxis, active haemoptysis * recent facial, oral, or skull surgery or trauma.
assessment of efficacy and safety uk-390,957 in men with premature ejaculation

Conditions: Ejaculation

Summary: assessment of efficacy and safety uk-390,957


Eligibility criteria:
inclusion criteria: * premature ejaculation as defined by dsm-iv exclusion criteria: * history of erectile dysfunction
nutritional intervention to reduce alcohol consumption

Conditions: Alcohol Use Disorder

Summary: to test whether the implementation of a modified ketogenic diet (kd) is efficient in reducing outcome measures in relation to alcohol consumption in patients with alcohol use disorder (aud).

this pilot study aims at testing randomization and feasibility of implementing a modified kd in patients with aud undergoing standard alcohol withdrawal treatment. for this purpose, a a standardized nutritional intervention consisting of interprofessional consultations by clinical dieticians and medical professionals will be implemented. patients in the control group will be randomized in an aud as usual treatment with an additional optional nutritional consultation. after dismission of inpatient care, the participants will be followed up for adherence to the modified kd in the outpatient clinic for 5 weeks.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * aud diagnosis according to diagnostic and statistical manual (dsm)-5 * bmi \> 22 (because of potential modified kd-side effect of weight loss) * able to give informed consent as documented by signature * last alcohol drink intake within 72 hours before treatment initiation exclusion criteria: * pregnant or lactating women, * inability or contraindications to undergo the investigated intervention (bmi\<18) * clinically significant concomitant diseases impairing reasonable decision making (e.g. psychosis, dementia) * inability to follow the procedures of the study, e.g. due to language problems, previous enrolment in a clinical trial * patients undergoing opioid maintenance treatment * patients taking medications for drinking relapse prevention * patients with a blood hemoglobin a1c (hba1c) \> 7%
using a novel functional mri technique to evaluate for neurotoxicity

Conditions: Central Nervous System Lymphoma

Summary: the purpose of this study is to test resting state functional magnetic resonance imaging (rsfmri) scans to see if rsfmri scans are better than the standard task based fmri scans at diagnosing or monitoring central nervous system lymphoma.


Eligibility criteria:
inclusion criteria: * immunocompetent patients with newly diagnosed or recurrent non-hodgkins lymphoma involving the brain (primary or secondary), as demonstrated by mri and histologic confirmation either by positive csf cytology for lymphoma or a monoclonal lymphocyte population defined by cell surface markers, vitreous or uvea biopsy or brain biopsy * age 18-80 years * treatment plan for hdc-asct * fluent in english * patients who in the judgment of the investigators and/or consenting professional, are able to understand the purpose of the study and provide informed consent will be included. exclusion criteria: * claustrophobia * any contraindication to the use of contrast and/or general guidelines for mr imaging as per standard department of radiology imaging guidelines * unable to cooperate for mri

Keywords: resting state functional magnetic resonance imaging rsfmri 17-403
a clinical trial of a pacifier-activated music player

Conditions: Prematurity

Summary: neonatal intensive care unit infants are at high risk for oromotor difficulties including poor coordination of sucking swallowing and breathing. these feeding difficulties often result in prolonged hospitalization, with increased physiologic stressors and poor growth. in preliminary studies, pacifier activated lullaby (pal) use showed potential increased oromotor skills and decreased length of hospitalization. the investigators propose to test the hypothesis that a week-long pal intervention can improve feeding skills and decrease stress compared to standard of care parental interactions in infants in the late preterm period. the investigators also hypothesize that these improvements will result in shorter hospital stays and increased growth in the intervention group. our study design is a prospective randomized controlled trial design of 94 infants (post-conceptional ages 34-36 weeks). the 47 intervention-group infant/mother dads will receive a book library with one lullaby book and record her voice to the pal, which the music therapist will then administer in 15-minute sessions for 5 consecutive days. the 47 participants in the control group will receive the same library but no recording will be made or pal used. outcomes measured will include time to full oral feeds, suck rate and efficiency, salivary cortisol levels before and after intervention, daily growth parameters and nutritional data, and hospital length of stay.

objectives: we conducted a randomized trial to test the hypothesis that the mother's voice played through a pacifier-activated music (pam) player during nonnutritive sucking would improve the development of sucking ability and promote more effective oral feeding in preterm infants. methods: preterm infants between 34 0/7 and 35 6/7 weeks postmenstrual age, including those with brain injury, who were taking at least half their feedings enterally and less than half orally, were randomly assigned to receive 5 daily 15-minute sessions of either pam with mother's recorded voice or no pam, along with routine nonnutritive sucking and maternal care in both groups. assignment was masked to the clinical team.

Eligibility criteria:
inclusion criteria: * all infants at 34 0/7 to 35 6/7 weeks post-conceptional age cared for in the vanderbilt nicu who are receiving more than 50 % of their nutrition as enteral feeds, and are in individual rooms or in the room with their sibling. exclusion criteria: * infants on ventilators or continuous positive airway pressure (cpap), * infants determined to be unsafe to feed orally by the medical team or the feeding/speech specialists at vanderbilt.

Keywords: neonatal intensive care unit (nicu) music therapy premature infant oral feeds non-nutritive sucking suck rate suck efficiency contingent music mother's voice
structured education and multidisciplinary team

Conditions: Pain; Anxiety; Activities of Daily Living

Summary: it is well-known that pre-operative education has a positive effect on patient recovery. this study was conducted to evaluate the impact of structured education given by a multidisciplinary team (surgeon, anesthesiologist, and nurse) on pain, anxiety, and activities of daily living in patients undergoing laparoscopic cholecystectomy.

in this randomized controlled study was conducted with 60 patients undergoing elective laparoscopic cholecystectomy in a training and research hospital in turkey between march and august 2019. the participants were divided into two equal groups. verbal structured education and written documents were given to the training group before surgery by a multidisciplinary team. the control group had the routine education. data were collected using a patient information form, the state anxiety inventory, a visual analog scale, and the barthel index for activities of daily living.

Eligibility criteria:
inclusion criteria: * undergoing an elective laparoscopic cholecystectomy * no loss of sensation related to vision and hearing * opening to communication and cooperation * no cancer diagnosis * no chronic pain-related treatment * no psychological disease diagnosis * agreeing to participate in the study exclusion criteria: * undergoing emergency surgery * hospitalized in the intensive care unit * average score below 62 by barthel index

Keywords: anxiety cholecystectomy education multidisciplinary team pain