Kornimate/medical-research-clean huggingface dataset:
the effect of mandala painting on anxiety in coronary heart patients

Conditions: Coronary Artery Disease; Anxiety

Summary: this study was planned as a randomized controlled trial to determine the effect of mandala painting on the anxiety of coronary heart patients.

patients in the control group will receive routine care.patiens in the experimental group will receive routine care and mandala painting. experimental group will paint mandala for 30 minutes/day in the evenings for six consecutive days. in order not to interrupt the duties of the nurse and doctor in the clinic, it was planned for the experimental group to paint mandalas in the evening. six pre-selected mandalas were planned to be printed separately on a4 paper. each patient will be given a new mandala each day. at the beginning of the study, six colors will be given to the experimental group (yellow, blue, green, red, purple, brown). it was planned to do it for 6 days, as it was found that painting mandala for more than a week in the studies could reduce the patient's attention. in addition, based on the average hospitalization days of the patients, reaching patients for more than a week will be a problem.

Eligibility criteria:
inclusion criteria: * having agreed to participate in the research/approved the informed consent form * no visual or hearing impairment * hospitalization due to coronary heart disease (patients hospitalized with the diagnosis of acute coronary syndromes such as stable angina, unstable angina, myocardial infarction, percutaneous coronary intervention and stent implantation), * being over 18 years old, * being at least literate * the absence of any problem that would prevent him/her from painting mandala (no problem in his arm or hand that would prevent his movement (such as paralysis, or the presence of a catheter on the hand), no serious illness) * must not have a diagnosis of mental illness/anxiety disorder exclusion criteria: * control group patients who coincided with the same room as the intervention group, by randomization. * patients who want to quit the study voluntarily during the study * patients whose general condition deteriorates (such as altered hemodynamics or consciousness)

Keywords: coronary artery disease anxiety mandala
treatment of major depressive disorder post stroke with transcranial direct current stimulation

Conditions: Major Depressive Disorder 1

Summary: stroke is one of the main public health problems in america latina. it can be associated with several neuropsychiatric complications, which include a broad spectrum of emotional distress and cognitive, results in important clinical implications for the prognosis of these patients. depression is a common complication, affecting around 5-72% of patients and is associated with various cognitive deficits and also with increased mortality - up to 50% more deaths compared to non-depressed patients. treatment of depression after stroke is important not only to improve depressive symptoms but can also be beneficial for cognitive deficits, activities of daily living. and leads to increased survival for these patients. there are different treatments for depression after stroke, all showing inconclusive results, even though antidepressants have been effective in some groups of patients, tolerability and treatment adherence were not very good-so it is necessary that new therapeutic modalities are presented with good tolerability. in this sense, transcranial direct current stimulation (tdcs) is an interesting technique that can provide interesting results, which proved to be effective for depression in some studies. this study proposes to investigate the effect of tdcs for the treatment of major depressive disorder after stroke. the proposed design is a clinical trial, randomized, double-blind, placebo-controlled study in a subsample of participants in the prospective cohort of stroke: study of morbidity and mortality of stroke. they will be allocated to one of the groups: sham or active tdcs group. participants will receive ten consecutive days of active or sham stimulation and return at the end of two weeks to evaluate the improvement in depression, cognition and functionality. as objectives, the investigators expect to see a clinical improvement of depression through scales like hamilton, beck and madrs(montgomery-asberg depression rating scale), and expect improvement on cognitive tests as moca (montreal cognitive assessment), mmse (mini mental scale exam), fab (frontal assessment battery) and trail test. another goal is to see improvement in markers related to depression as bdnf, cortisol, interleukins and heart rate variability. with all this, the investigators hope to offer a new treatment, and effective with few side effects to treat depression after stroke.

the study of morbidity and mortality of stroke (emma) is a cohort study of patients with stroke.

Eligibility criteria:
inclusion criteria: * major depressive disorder after stroke * first episode of stroke * hamilton \> 17 exclusion criteria: * others severe neurologic conditions * others axis i besides anxiety * important suicidal ideation * use of antidepressants

Keywords: tdcs major depression stroke
ovarian function of nasopharyngeal carcinoma women survivors

Conditions: Nasopharyngeal Carcinoma

Summary: this is an observational cohort study aimed to explore the fertility concerns, fertility preservation strategies, fertility status (pregnancy and ovarian failure) and birth outcome among young woman nasopharyngeal carcinoma patients.

the purpose of this study was to explore the effects of radiotherapy and chemotherapy on ovarian function and pregnancy outcome after treatment in female survivors of non-metastatic nasopharyngeal carcinoma, so as to clarify the relationship between ovarian dysfunction after treatment and pregnancy outcome, as well as clarify the relationship between pregnancy after treatment and tumour progression.

Eligibility criteria:
inclusion criteria: 1. patients with newly histologically confirmed non-keratinizing nasopharyngeal carcinoma, including who ii or iii ,with no distant metastasis 2. age between 18-45, female 3. eastern cooperative oncology group (ecog) performance status (ps) 0 or 1 4. alanine aminotransferase (alt) and aspartate aminotransferase (ast) ≤2.5×upper limit of normal (uln),serum total bilirubin (tbil) ≤2.0 times the upper limit of normal (uln) . 5. adequate renal function: creatinine clearance rate≥60 ml/min or creatinine ≤1.5× upper limit of normal value. 6. no history of infertility. 7. no history of hysterectomy or bilateral ovariectomy. 8. patient have signed on the informed consent, and well understood the objective and procedure of this study exclusion criteria: 1. histologically or cytologically confirmed with keratinizing squamous cell carcinoma of the nasopharynx. 2. women in the period of pregnancy, lactation, or reproductive without effective contraceptive measures. 3. known history of other malignancies (except cured basal cell carcinoma or carcinoma in situ of the cervix). 4. patients with severe dysfunction of heart, liver, lung, kidney or marrow. 5. patients with severe, uncontrolled disease or infections. 6. refuse or fail to sign the informed consent . 7. patients with personality or mental disorders, incapacity or limited capacity for civil conduct.

Keywords: nasopharyngeal carcinoma ovarian function pregnancy outcomes
the effect of inhaled n-acetylcysteine compared to normal saline on sputum rheology and lung function

Conditions: Cystic Fibrosis

Summary: inhalation treatment with mucolytics is one of the cornerstones of cf treatment for respiratory problems. the efficacy of inhalation treatment with recombinant dnase and hypertonic saline is well established. the north american cf foundation reported that there is insufficient evidence for or against the chronic use of inhaled n-acetylcysteine (nac) to improve lung function and reduce exacerbations . in vitro tests proved the positive effect of nac on sputum rheology . evidence based research however on the in vivo effect of nac on visco-elasticity and lung function is rare. there are only three randomized controlled clinical trials on nebulised nac, none of them showing a statistically significant or clinically relevant beneficial effect. nevertheless at least in europe for many years inhalation treatment with nac is advised. because of the disgusting sulphur odour, many patients are reluctant to use this inhalation medication. we intend to start an open placebo controlled in vivo cross-over study to evaluate the effect of acetyl cysteine compared to normal saline on the sputum visco-elasticity and on the short term effect on lung function. sputum producing cf-patients, able to perform lung function tests will be enrolled. sputum viscoelasticity will be measured by a controlled-stress rheometer (ar 1000-n; ta-instruments, ghent, belgium) at 20° c, using a cone-plate geometry 8. lung function measurement (fvc, fev1, fef 25-75) will be done in a masterlab body plethysmograph (jaeger®) sputum samples will be collected before lung function test on a regular control visit. three ml of nac or 4 ml of normal saline will be inhaled, afterwards a second sputum sample will be collected and a control lung function test will be performed. visco-elasticity measurements will be done on sputum samples before and after inhalation of nac or normal saline. patients will continue to inhale n-acetylcysteine or normal saline two times per day for one month. after one month a control lung function and a third sputum sample will be collected, visco-elasticity and lung function will be measured and compared to the initial values in both groups and between groups. after a wash-out period of normal saline inhalations during 2 weeks in both groups, patients in the initial control group will be asked to switch to inhalation of 3 ml of nac two times per day and the former nac group will continue to inhale two times 4 ml of normal saline during four weeks. after one month the same measurements of visco-elasticity and lung function tests will be done.


Eligibility criteria:
inclusion criteria: * patients who can perform lung function tests and who can produce sputum (\> 5 years of age) * (fe)males between 6-64 years exclusion criteria: * patients on the waiting lists for lung transplant. * pregnancy or breast feeding * patients can not take part in another 'inhalation'trial for cystic fibrosis
acceptable range of inspiratory effort during mechanical ventilation

Conditions: Elective Cardiac Surgery

Summary: partially assisted mechanical ventilation is ideally titrated to maintain adequate inspiratory muscle activity (i.e. preventing disuse atrophy) while avoiding excessive (i.e. fatiguing) inspiratory loads. the advent of ventilator modes enabling flow and pressure assistance in proportion to patient inspiratory effort (i.e. proportional assist ventilation (pav), neurally-adjusted ventilator assist (nava)) permit careful titration of ventilatory support to achieve desired levels of patient inspiratory effort. however, data on the acceptable range of values for inspiratory effort and respiratory muscle load-capacity balance during mechanical ventilation are currently very limited. such data are critical to inform a physiologically sound evidence-based approach to titrating partially-assisted ventilatory support. this study is designed to ascertain a physiologically acceptable range of inspiratory effort in mechanically ventilated patients. the study protocol includes measurements of the respiratory system during spontaneous breathing as well as evaluating the diaphragm in real-time with the use of ultrasonography. the experimental design outlined in the present study is predicated on the assumption that the range of values for inspiratory effort and load-capacity balance observed in patients who are successfully weaned from mechanical ventilation represent the safe and appropriate range of target values.


Eligibility criteria:
inclusion criteria: - adult patients (\>17) receiving invasive mechanical ventilation following elective cardiac surgery who will undergo a trial of spontaneous breathing exclusion criteria: * pregnant women * decompensated cardiac insufficiency or acute coronary syndrome * severe copd * contraindications to esophageal catheter placement, namely known esophageal varices

Keywords: spontaneous breathing trial inspiratory effort mechanical ventilation respiratory muscle load-capacity balance
the effects of post-conditioning and administration of vitamin c on intramuscular high energy phosphate levels

Conditions: Ischemia Reperfusion Injury

Summary: ischemic injury to muscular tissue is common in cardiovascular medicine. the most effective treatment to avoid ischemic damage is the rapid re-establishment of reperfusion. however, reperfusion itself can result in additional damage to ischemic tissue. this phenomenon is called ischemia - reperfusion (ir) injury and is caused by different pathologic mechanisms. therapies are required which can be administered after the onset of an ischemic event to protect the tissue against ir injury. therefore, a promising strategy to reduce ir injury is post-conditioning. likewise, pharmacological therapies administered after the onset of reperfusion might prevent tissue injury. we have recently shown that high concentrations of exogenous vitamin c abrogate experimental ir injury of the forearm vasculature in patients with peripheral artery disease and in healthy subjects. study hypothesis we hypothesize that the administration of mechanical post-conditioning or of high-dose vitamin c may protect skeletal muscle against ir injury. this shall be studied employing mr spectroscopy of the leg, which is an established model to assess muscle aerobic energy metabolism. design three periods, three way cross over study in 10 volunteers. one screening visit, three one-day study days with two washout periods of \>3 days in between are scheduled for each participant. the order of experimental days will be randomized. after the last treatment a final follow-up examination will be performed within one week.


Eligibility criteria:
inclusion criteria: * men aged between 18 and 45 years * nonsmoker for more than 3 months * body mass index between 18 and 25 kg/m2 * normal findings in medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant exclusion criteria: any of the following will exclude a subject from the study: * regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study * evidence of hypertension, pathologic hyperglycemia, hyperlipidemia * treatment in the previous 3 weeks with any drug including over-the-counter drugs. * symptoms of a clinically relevant illness in the 2 weeks before the first study day * history or presence of gastrointestinal, liver of kidney disease, or other conditions known to interfere with distribution, metabolism or excretion of the study drug * blood donation during the previous 3 weeks * history of hypersensitivity to parenteral vitamin c. * glucose-6-phosphate dehydrogenase deficiency * thalassemia, haemochromatosis * history of urolithiasis * any metallic or paramagnetic device not removable * claustrophobia * regular use of supplementary oral vitamin c or vitamin c containing substances

Keywords: ir injury mri vitamin c postconditioning
dedicated sheath feasibility study

Conditions: Aortic Stenosis

Summary: dedicated sheath feasibility study: a prospective, open-label study to evaluate the feasibility and safety of the valve medical dedicated sheath during balloon aortic valvuloplasty (bav).

this is an open-label, prospective, single arm clinical study. up to 15 patients undergoing valvular intervention will be enrolled. follow up will take place at 1, 6 and 24 hours post procedure. no follow up visits are required. during the study, the patient will undergo the following tests: * physical examination (includes blood pressure, age, height, weight). * echo assessments prior to procedure. * hemodynamic study prior and post bav. * full blood count * angiography

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * patient understands the implications of participating in the study and provides written informed consent. * the patient has an indication for balloon aortic valvuloplasty (bav). exclusion criteria: * peripheral vessel anatomy or peripheral vascular disease that would preclude the insertion of the 12 fr. sheath. * any illness or condition which, in the investigator's judgment, will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results.

Keywords: dedicated sheath
rhythmic auditory stimulation optimalization for gait improvement in parkinson's disease - beatpark study

Conditions: Parkinson's Disease

Summary: the beneficial effects of rhythmical auditory stimulation (ras) on spatio-temporal gait characteristics in parkinson's disease (pd) are attested by clinical research. nonetheless, it is still unclear which auditory information parameters (i.e. complexity, temporal regularity or adaptability to gait) maximize the effectiveness of ras. objectives: to evaluate the beneficial effects of ras on spatio-temporal gait characteristics in pd patients with gait disorders according to: * ras complexity (i.e. metronome, amplitude modulated noise, music) * ras variability (i.e fixed, random, semi-random) * ras adapted in real-time to gait variability study: to study the impact of ras variability (i.e fixed, random, semi-random) in 20 pd patients and 20 healthy controls on spatio-temporal gait characteristics with metronome, amplitude noise and music. adaptability studyto study the impact of ras adaptability (i.e fixed, random, adapted in real-time to gait) in 20 pd patients and 20 healthy controls on spatio-temporal gait characteristics with metronome, amplitude noise and music.


Eligibility criteria:
inclusion criteria: * 18 y.o. * to be able to understand the study aims and to agree to participate * to have signed the consent form * to be registered to social security system * to reach the diagnosis criteria of idiopathic pd (queen square brain bank) * gait disorder clinically observable exclusion criteria: * pregnant or lactating woman * high probability of non-compliance * curators , authorship or advisers to person of full age specific exclusion criteria for pd patients * clinical signs of parkinsonian syndrome * mini mental state examination \< 24/30 specific exclusion criteria for controls * neurological disease * gait disorder

Keywords: parkinson's disease rhythmic auditory stimulation gait
melt - mri evaluation of lymphoma treatment

Conditions: Lymphoma, Hodgkin

Summary: patients who are newly diagnosed with hodgkin's lymphoma will undergo disease staging at diagnosis and initial treatment response assessment. at each time point (initial staging and treatment response assessment) in addition to standard imaging investigations (pet ct, chest ct, anatomical mri of the abdomen and pelvis and abdominal uss), patients will undergo an extended mri scan.

the trial will be a single centre cohort study in patients newly diagnosed with hodgkin's lymphoma undergoing disease staging at diagnosis and initial treatment response assessment. at each time point (initial staging and treatment response assessment) in addition to standard imaging investigations (pet ct, chest ct, anatomical mri of the abdomen and pelvis and abdominal uss), patients will undergo advanced anatomical and functional mri sequences.

Eligibility criteria:
inclusion criteria: * aged 5 to 20 years (inclusive) with participant and parent/guardian informed consent * histologically confirmed first presentation of hodgkin's lymphoma * either entered into the euronet phl-c1 trial or lp1 trials or not formally entered into the euronet trials but treated on the chemotherapy regimens of the euronet trials for classical and lymphocyte predominant hodgkin lymphoma exclusion criteria: * contraindications to mri (e.g. pacemaker) * previous malignancy or previous chemotherapy or radiotherapy treatment for malignancy * pregnancy or nursing
beneficial effects of self-hypnosis/self-care for chronic pain patients : a mri and eeg study

Conditions: Chronic Pain

Summary: chronic pain concerns one in four adults in belgium. fibromyalgia is an example of chronic pain and is characterized by diffused and migrant musculo-tendinous pain localized in the limbs and at an axial level. the technological improvement in neuroimaging allowed to improve, at a cerebral level, the identification of the structural and the functional characteristics of this clinical entity. studies indicated a modification in cerebral morphometry showing an alteration of white and grey matter in the anterior cingulate cortex, orbitofrontal lateral cortex, cerebellum, basal ganglia, insula, secondary somatosensory cortex, thalamus, amygdala, putamen, superior temporal gyrus and periaqueductal grey matter. at a functional level, studies show un alteration in the connectivity of the default mode network, an atrophy of zones implicated in nociception and an increased activation of zone implicated in response to a nociceptive stimulus. nowadays, researchers are interested in finding out the beneficial effects of non-pharmacological techniques to improve de well-being of patients with chronic pain. hypnosis is one of these techniques that has already proven to be successful in decreasing pain and improving global quality of life. nevertheless, to our knowledge, no study has been conducted to understand the impact of hypnosis upon the cerebral functioning of these patients. therefore, the aim of this study is to understand the impact of a 6 months self-hypnosis/self-care learning program upon the structural and functional functioning of the brain by means of functional magnetic resonance imagery (fmri) and electroencephalography (eeg).


Eligibility criteria:
inclusion criteria: * major * fluency in french * fibromyalgia diagnosis exclusion criteria: * neurologic disorder * psychiatric disorder * drug addiction * alcoholism

Keywords: chronic pain fibromyalgia hypnosis fmri eeg
the impact of covid-19 pandemic to trauma patients in emergency department: a multicenter experience of istanbul

Conditions: Trauma; Covid19

Summary: covid-19, which emerged in china in december 2019, has become a pandemic with its spread to many countries of the world. the aim of this multi-centered study is to guide for the approach, organization, diagnosis and treatment of the patients admitted due to trauma to emergency department during the pandemic period.

covid-19, which emerged in china in december 2019, has become a pandemic with its spread to many countries of the world. the investigators hypothesize that since the number of hospital applications expected to be decreased due to trauma during the covid-19 period, the level of hospital trauma applications changed. thus, the aim of this multi-centered study is to guide for the approach, organization, diagnosis and treatment of the patients admitted due to trauma to emergency department during the pandemic period.

Eligibility criteria:
inclusion criteria: * accepted to participate with an informed consent * trauma patients who admitted to the study centers exclusion criteria: * lack of informed consent * lack of data