Kornimate/medical-research-clean huggingface dataset:
addressing behaviour and treatment effectiveness project (a.b.a.t.e. project)

Conditions: Disruptive Behavior Disorder

Summary: this study investigates the effectiveness of a clinic-adapted version of the coping power program compared to individualized child and family treatment for children with disruptive behaviour and their parents.

this project compares the short- and long-term effectiveness of a clinic-adapted manualized group treatment (i.e., coping power; cp) to individualized child and family treatment for children aged 9 - 12 with disruptive behaviour. children and their parents who meet criteria and agree to participate in the project are randomly assigned to either the cp condition or the individualized treatment condition. in the cp condition, children and caregivers are asked to participate in two separate but complimentary 15-session groups. child groups target development of children's emotional and cognitive problem solving skills and caregiver groups facilitate cognitive and behavioural parenting skills. in the individualized treatment condition children and caregivers are asked to participate in 15 one-hour individual and family treatment sessions tailored by the clinician to address the children and parent's presenting concerns. measurement of behaviour and emotional functioning is done pre- post- and at 6-months following treatment.

Eligibility criteria:
inclusion criteria: * parents provide free and informed consent and children assent to participate in the research, complete measures, and participate in either coping power or individualized treatment. * parents report symptoms consistent with clinical diagnoses of oppositional defiant disorder or conduct disorder on the diagnostic interview schedule for children - dsm iv or parents and/or teacher report at or above a t-score of 60 (93rd percentile; borderline clinically severe range) on the externalizing behavior composite scale on the behavior assessment for children - 2nd edition. * parents or teachers report clinically severe impairment in social, family, peer or overall functioning demonstrated by scores in the clinical range on the parent or teacher completed impairment rating scale. * the child's cognitive functioning is at or above a standard score of 80 (borderline range) on the verbal and/or nonverbal scales on the kaufman brief intelligence task - 2. exclusion criteria: * evidence of autism spectrum disorder or asperger's disorder as reported by parent, teacher or physician referral (if available).

Keywords: disruptive behaviour disorder psychosocial group treatment
efficacy and safety of accell evo3 demineralized bone matrix (dbm) in instrumented posterolateral lumbar spine fusion

Conditions: Stenosis; Spondylosis; Degenerative Changes

Summary: the objective of this study is to prospectively evaluate the performance of integra accell evo3 demineralized bone matrix as an adjunct for posterolateral spine fusion with a retrospective comparison to a historical patient cohort.

the objective of this study is to prospectively evaluate the performance of integra accell evo3 demineralized bone matrix as an adjunct for posterolateral spine fusion with a retrospective comparison to a historical patient cohort. the historical patient cohort has not been previously published and therefore, no reference to this group can be provided.

Eligibility criteria:
inclusion criteria: * age 18 years of age or older at the time of surgery * require spinal fusion using posterior transforaminal lumbar interbody fusion (tlif), posterolateral fusion (plf) or posterior lumber interbody fusion (plif) in 1 to 3 levels between l3-s1 * follow-up radiographic imaging post surgery exclusion criteria: * long term users of medications known to inhibit fusion,bone metabolism or epidural steroid injections * immunosuppressive agents, disease modifying anti-rheumatic drugs (dmards) or any similar immunomodulating drugs, growth factors or insulin * treated with radiotherapy since their surgery * medical conditions known to impact bone metabolism, such as paget's disease, osteoporosis * pregnant or lactating women or women wishing to become pregnant * prisoner * participating in an investigational drug or another device study
efficacy of spironolactone in cameroonian diabetic patients with resistant hypertension

Conditions: Hypertension, Resistant to Conventional Therapy; Diabetes Mellitus

Summary: this is a four-week randomized controlled single blinded trial of subjects presenting with resistant hypertension in a specialized diabetes care unit of cameroon. they are randomly assigned using the method of blocks to treatment with a daily 25mg of spironolactone or to routine intensification of antihypertensive regimen , all added to previous regimen with unchanged diet. visits are scheduled at the start of the treatment, at weeks two and four following add-on therapy initiation. the primary outcome is change in office and self-measurement blood pressure recorded at each visit, and secondary outcomes are variations in serum potassium, sodium, and creatinine levels.


Eligibility criteria:
inclusion criteria: * resistant hypertension * diabetes mellitus exclusion criteria: * t2dm with overt acute/chronic complications, * serum potassium ≥ 5.5 mmol/l, * estimated glomerular filtration rate (egfr) calculated using the modification of diet in renal disease formula ≤ 30 ml/min/1.73m² of body weight, * absolute contraindication to any of the drug regimen of the trial, * and current aldosterone antagonist treatment or cessation within the last 15 months

Keywords: resistant hypertension diabetes mellitus spironolactone african
single versus multi-port robotic assisted sacrocolpopexy for repair of vaginal apex prolapse

Conditions: Pelvic Organ Prolapse

Summary: a prospective randomized controlled study intended to compare the efficacy of 2 methods of robotic assisted sacrocolpopexy for the repair of vaginal apex prolapse: 1. via single-port. 2. via multi-port.

one hundred female patients diagnosed with vaginal apex prolapse will be recruited to a prospective randomized controlled study intended to compare the efficacy of 2 methods of robotic assisted sacrocolpopexy: 1. via single-port. 2. via multi-port. the patients will be evaluated and randomized 2 weeks before the expected date of surgery during which eligibility will be examined. patients' electronic files will be reviewed post operatively to acquire information regarding medical history, prolapse scores, surgical information, anesthesia information and surgical complications. patients will have 3 week and 3 month post operative follow-up sessions to determine surgical success, late complications and patient satisfaction.

Eligibility criteria:
inclusion criteria: * female patients with vaginal apex prolapse that are eligible for repair by sacrocolpopexy. exclusion criteria: * patients after previous hysterectomy. * patients after previous surgical procedures for prolapse repair.
to comapre the effectiveness of two lasers in the treamment of unwanted hair

Conditions: Hirsuitism

Summary: a total of 60 female patients (30 patients in each group) with unwanted facial hair diagnosed by a consultant dermatologist were included in this study. in group a patients were subjected to intense pulse light therapy while patients in group b were subjected to diode laser for three sessions one month apart. effectiveness in both groups was ascertained in terms of hair reduction, less adverse effects, side effects and patients' satisfactory response at the end of final session.


Eligibility criteria:
inclusion criteria: * female patients with hirsuitism were included in the study. exclusion criteria: * tendency to develop hypertrophic scarring/keloid, * underwent any treatment for unwanted facial hair in last two years * pregnant/lactating women * with hormonal imbalance and pcos were also not in included in the study.
brief behavioral treatment for sleep problems in ibs study

Conditions: Irritable Bowel Syndrome; Sleep Disturbance

Summary: patients with irritable bowel syndrome (ibs) often report more fatigue and sleep disturbances compared to their healthy counterparts and compared to patients with other gi disorders. this pilot study will evaluate the feasibility of a brief behavioral treatment for insomnia (bbt-i) in irritable bowel syndrome. 40 participants will be recruited; 20 will receive 4 weeks of bbt and 20 will be assigned to a wait list control group (wlc). the primary aim of the current project is to assess feasibility of administering bbt-i to a sample of patients with ibs. because behavioral sleep treatment has not yet been studied in ibs or any other gi population, this project will provide information about treatment adherence, recruitment, and effect sizes. secondary aims include evaluating the impact of bbt-i on sleep quality and ibs symptom severity.


Eligibility criteria:
inclusion criteria: * age 20-50 * meet diagnostic criteria for ibs * stable medication for ibs for at least 1 month * stable medication for sleep for at least 1 month * isi cutoff score of 10 or higher * completes at least 5 out of 7 days of daily symptom and sleep diary during 1 week baseline exclusion criteria: * medical history of significant head injury or other neurological disorder * pregnancy (self-reported) * post-menopause * major concomitant medical conditions * major psychiatric diagnosis with comorbid sleep problems * taking medications that might interfere with sleep * confirmed or suspected other untreated sleep disorder * active illicit drug use
smiley face shaped rod technique versus instrumented posteriolateral fusion in treatment of isthmic lumbar spondylolisthesis

Conditions: Isthmic Spondylolisthesis

Summary: aim of research is to investigates clinical, surgical and radiological outcome of vertebral pars intetarticularis repair by used smile face shape rod technique and bone grafting and comparing that with posteriolateral fusion with used traditional transpedical screw and rod fixation in management of isthmic spondylistheisis

isthmic spondylolisthesis is considered to represent a fatigue fracture of the pars interarticularis of the neural arch, the clinical symptom is activity-related back pain in young and athletic patients . the cause of isthmic spondylolisthesis in these patients is repetitive stress of the pars interarticularis with subsequent microfracture, which in turn may lead to a bony defect and cause progressive spondylolisthesis in up to 25% of cases. surgical intervention is indicated for patients who are not responsive despite adequate period of conservative management such as activity modification , physical therapy, and occasionally bracing . techniques for repair of a pars defect include scott wiring , a buck screw , a pedicle screw and hook , multiple segment fixations or a u-rod . after repair, radiographic healing rates range from 67 percent to 90 percent; asymptomatic and return to sports rates range from 80 percent to 90 percent. these methods have achieved variable success .in buck screw fusion surgery,it is not effect on flexion and axial rotation of the spine but bone healing is compromised. stabilization with wiring and titanium cable had less success rate than other methods and requires the use of lumbar brace or prolonged immobilization. the pedicle screw-vertebral plate hook system may complicated by injury to the dural sac or nerves ensues. multiple segment fixation with pedicle screws and rods has good success of stabilization but it is effect on flexion and axial rotation of the spine, and may cause degenerative change in adjacent normal segments. smiley face shaped rod technique is new method used for repair of isthmic spodylolisthesis using pedical screw on effected segment and smiley face rod revolve around spinal process to stabilization of pars interarticularis of the same segment so it preserve axial rotation and flexion of spin also avoid degenerative change in adjacent levels.

Eligibility criteria:
inclusion criteria: 1. age above 18 years old 2. both sex 3. failure of conservative treatment for 3months 4. fit for surgery exclusion criteria: 1. age less than 18 2. not fit for surgery 3. pathological fracture of pars 4. assosciated pathology like disc degeneration, spinal canal stenosis, spondylolisthesis grad 2,3and 4
the acute t-rex (timing of resistance exercise) study

Conditions: Diabetes Mellitus, Type 2; Insulin Resistance; Glucose Intolerance; Sleep Disturbance; Overweight or Obesity; Insulin Sensitivity

Summary: the primary aim of this study is to evaluate if a single bout of am vs pm resistance exercise has different effects on insulin sensitivity and sleep. a randomized cross-over trial be used to compare resistance exercise at two different times of the day. each condition will take place in a laboratory setting. each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. the am exercise will occur \~1.5 hours after habitual wake, and pm exercise will occur \~11 hours after habitual wake. after a 2-6 week washout, participants will complete the other condition. the hypothesis is that pm exercise will be more beneficial than am exercise in improving insulin sensitivity. this study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing type 2 diabetes mellitus.


Eligibility criteria:
inclusion criteria: * men and women, all ethnicities, aged 50-74 years * bmi ≥25 kg/m² and \<45 kg/m² * weight stable (less than 5% change in the past 6 months) * generally healthy individuals * not meeting recommended activity guidelines for aerobic or resistance exercise exclusion criteria: * uncontrolled cardiovascular, metabolic, renal, or pulmonary disease * cancer treatment in the past 5 years * untreated thyroid disease or other medical conditions affecting weight or energy metabolism * current use of weight loss medication or other medications likely to impact energy balance * bariatric surgery or extensive bowel resection in the past 2 years * current or recent history (past 2 years) of eating disorder * diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders * non-english speaking * hba1c \>6.5%

Keywords: resistance exercise strength-training sleep circadian rhythm
rapid versus conventional titration of quetiapine in schizophrenia/schizoaffective disorder

Conditions: Schizophrenia; Schizoaffective Disorders; Psychotic Disorders

Summary: the purpose of this study is to determine whether increasing the amount (dose) of quetiapine ir (immediate release formulation) more rapidly than conventional dose increases, improves the control of symptoms as measured by the positive and negative syndrome scale (panss) - a psychiatric assessment scale that measures both positive and negative symptoms - in patients with acute schizophrenia or schizoaffective disorder.


Eligibility criteria:
inclusion criteria: * men and women, aged 18 to 65 years, who require treatment for an acute episode of schizophrenia/schizoaffective disorder as judged by their doctor exclusion criteria: * significant and unstable conditions of hear, circulation, blood, liver, kidney; malignancies (cancer); diabetes (mellitus); history of fits or fainting. resistance to antipsychotic medication. current alcohol/drug abuse. pregnant/breast feeding women.

Keywords: schizophrenia schizoaffective disorder quetiapine seroquel titration
aiberry ai mental health screening platform

Conditions: Depression; Anxiety; Healthy

Summary: aiberry is creating a multi-modal artificial intelligence (ai) platform that analyzes facial, audio and text features to screen for mental illness. this multicenter study will be used to collect data to validate the platform's ability to detect depression and anxiety in a diverse patient population.

aiberry is developing a proprietary ai platform that leverages machine learning to screen for mental illness using a multi-modal approach that fuses rich visual, audio, text, gestures, and eye gaze information. our objective in this study is to validate algorithms that predict how individuals will respond to self-report questionnaires used to screen for major depressive disorder (mdd) and general anxiety disorder (gad). prior to enrollment, participants will participate in a baseline screening questionnaire to collect demographic information, health history, and current depression severity. if participants meet eligibility requirements and demographic recruitment targets, they will be invited to a single virtual study visit in which they will complete a 10-15 minute recorded interview with a study staff member along with three brief self-report questionnaires: 1) the quick inventory of depression symptoms self report (qids-sr-16), 2) the general anxiety disorder (gad-7), and 3) the mini-version of the mood and anxiety questionnaire (mini-masq), which will be used as a validity check that participant responses are consistent between this and the previous two questionnaires. we will evaluate how well the ai technology is able to predict self-reported symptoms of depression and anxiety by analyzing facial, audio, and text features from interview videos.

Eligibility criteria:
inclusion criteria: * age 13 to 79 years old * english-speaking exclusion criteria: * previous participant in the study, within the last three months * individuals unable to verbally respond to standardized questions * individuals unable to participate in a virtual visit as they do not have the right hardware (phone/laptop) or no internet connectivity * individuals unable to provide consent
investigation of a novel turbine-driven ventilator for use in cardiopulmonary resuscitation

Conditions: Cardiac Arrest; Hyperventilation

Summary: the objective of this study is to determine whether healthcare professionals trained in cpr can deliver more effective ventilations during cpr using the handivent, a novel turbine-driven ventilator as compared to bag-valve-mask ventilations, using a manikin model. the investigators believe the handivent will deliver a more accurate respiratory rate and tidal volume, with lower intrathoracic pressure during cpr.

previous studies have shown that increased respiratory rate during cpr inversely correlates with blood pressure. higher respiratory rates increase intrathoracic pressure, which in turn decreases venous return to the heart. in one previous study, the authors looked at 3 groups of 7 pigs, ventilated at 12 (100% o2), 30 (100%), and 30 (5% co2, 95% 02) breaths per minute during cardiac arrest, and showed increased mortality with increasing respiratory rate. survival rates were 6/7, 1/7, and 1/7 respectively. the results of this study led to changing the cpr guidelines in 2005 to include fewer ventilations. the authors also observed 13 cases of cpr in the field and noted ems personnel delivered breaths at an average of 32 bpm. in 2012, a similar study to the current study under proposal compared a pressure-limited, pneumatically driven ventilator to bag-valve-mask in simulated cpr, using medical student volunteers. that study did not show a significant difference in tidal volumes; however, they did not record respiratory rates or mean intrathoracic pressures. furthermore, that ventilator was pneumatically -driven and pressure limited, whereas the ventilator we propose to study is turbine-driven and can be volume/time triggered.

Eligibility criteria:
inclusion criteria: * acls- certified healthcare professional exclusion criteria: * none
the investigation of the neonates with or with risk of covid-19

Conditions: Neonatal Infection; Perinatal Problems; Infectious Disease

Summary: since december 2019, there has been an outbreak of novel coronavirus pneumonia in china. as of february 18, 2020, 72,530 cases confirmed with 2019 coronavirus disease(covid-19) have been reported and 1,870 deaths were declared. until now, cases of covid-19 have been reported in 26 countries. this observational study aims to analysis the clinical features of neonates with covid-19 and the neonates born to mother with covid-19.

given that severe acute respiratory syndrome coronavirus 2 (sars-cov-2) spreads rapidly and is contagious to the general population, all the suspected or confirmed newborns will be admitted to the neonatal departments in designated hospitals of china. in this study, the diagnosis of neonatal sars-cov-2 infection is based on the criterion provided by national health commission and the chinese perinatal-neonatal sars-cov-2 committee. all samples will be treated as biohazardous material. sars-cov-2 will be tested in blood, cord blood, amniotic fluid, placenta, respiratory tract, stool, urine from mothers or neonates. the medical information questionnaires are classified into maternal and neonatal version, which include demographic details, epidemical history, clinical manifestations, tests collected time and results, imaging performed time and results and therapeutic data. two researchers independently checked and recorded the data to ensure the accuracy of the data.

Eligibility criteria:
inclusion criteria: * the neonates with covid-19,or neonates born by infected mothers exclusion criteria: * the neonates with major anomalies
two-level espb in total knee arthroplasty

Conditions: Knee Osteoarthritis; Knee Pain Chronic; Knee Arthritis

Summary: effect of two-level espb in total knee arthroplasty

knee arthroplasty is one of the most common orthopaedic procedures, especially in elderly patients, due to the deformation of joints. patients may complain of severe pain due to surgical trauma and prostheses. regional anaesthesia methods may be performed to reduce the inflammatory response, opioid consumption, and opioid-related side effects.

Eligibility criteria:
inclusion criteria: * patients scheduled for total hip arthroplasty * patients aged \>65 and \<100 years * patients able to provide informed consent * patients able to reliably report symptoms to the research team exclusion criteria: * inability to provide first-party consent due to cognitive impairment or a language barrier