Kornimate/medical-research-clean huggingface dataset:
management of diabetic patients with neuropathic osteoarthropathy (charcot foot) : descriptive study in diabetic-foot centers

Conditions: Diabetic Foot Neuroarthropathy Charcot

Summary: despite the prominence of diabetes prevalence (more than 8% of the world population in 2012) and its expected increase in the next 15 years, charcot foot remains a widely unknown diabetes complication. at this day, there is no national guidelines about diagnosis and treatment of this complication, which is known to alter life quality and to increase risk of foot ulceration and mortality in diabetics. through this descriptive multicentric study, we will investigate the charcot foot cares in diabetic-foot centers in france and belgium.


Eligibility criteria:
inclusion criteria: * the patient has received written information about the study and did not oppose to participate * the patient is affiliated to a health insurance programme * the patient is at least 18 years old * the patient is admitted to hospitalization or consultation * the patient is diagnosed with type 1 or type 2 diabetes mellitus * the patient is diagnosed with acute or chronic osteo-neuroarthropathy exclusion criteria: * the patient participates in another interventional study * the patient refuses to participate
mobile sensing and support for depression

Conditions: Depression

Summary: the objective of this study is two fold, first to explore the potential of context sensitive intervention delivery to provide in-situ support for people with depressive symptoms, second to explore the detection of daily-life behavior based on smart phone sensor information to identify subjects with a clinically meaningful depression level.

to conduct a very first pilot trial, a monocentric, single-arm clinical study is conducted. the study is approved by the local ethics committee of the canton of zurich in switzerland and the swiss agency for therapeutic products. it is conducted in full accordance with the declaration of helsinki, with all subjects providing their electronic informed consent prior to participation. as the main interest lies in a proof of concept of the proposed moss app, emphasis is put on real life conditions. a range of different recruitment channels is used to attract subjects from the general public; they include physical flyers, online posts on relevant online bulletin boards and the google play store.

Eligibility criteria:
inclusion criteria: * self-declaration of depressive symptoms * app runs on android 4.0 and higher * germen speaking exclusion criteria: * psychotic symptoms * bipolar symptoms * drug or alcohol dependency * dementia
a study to evaluate the pharmacokinetics, safety, and tolerability of abbv-932 in healthy adult participants, participants with generalized anxiety disorder (gad) and participants with bipolar disorder (bpd)

Conditions: Healthy Volunteers; Generalized Anxiety Disorder (GAD); Bipolar Disorder (BPD)

Summary: the purpose of this study is to assess the pharmacokinetics, safety, and tolerability following multiple ascending oral doses of abbv-932 or placebo in healthy adult participants, participants with generalized anxiety disorder (gad), and participants with bipolar disorder (bpd).


Eligibility criteria:
inclusion criteria: * for healthy volunteer cohort: -- body mass index (bmi) is \>= 18.0 to \<= 32.0 kg/m2 after rounding to the tenths decimal. * for participants with generalized anxiety disorder (gad) or bipolar disorder (bpd) * participants with gad or bpd (as confirmed by mini) meet participant psychiatric history criteria described in the protocol. exclusion criteria: - history of any clinically significant illness/infection/major febrile illness, hospitalization, or any surgical procedure within 30 days prior to the first dose of study drug.

Keywords: abbv-932 generalized anxiety disorder (gad) bipolar disorder (bpd)
limb remote ischemic preconditioning reduces heart and lung injury after abdominal aortic aneurysm repair

Conditions: Abdominal Aortic Aneurysm

Summary: to investigate whether limb remote ischemic preconditioning (lrip) has protective effects against intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (aaa) repair.

remote ischaemic preconditioning may confer the cytoprotection in critical organs. we hypothesized that limb remote ischemic preconditioning (ripc) would reduce intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (aaa) repair.the primary outcomes included the biomarkers reflecting intestinal injury (serum intestinal fatty acid binding protein, endotoxin levels and diamine oxidase activity) and the variables reflecting pulmonary injury (arterial-alveolar oxygen tension ratio, alveolar-arterial oxygen tension difference and respiratory index). in addition, the severity of intestinal and pulmonary injury was assessed with different scoring methods, respectively. markers of oxidative stress and systemic inflammation were measured as well.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of abdominal aortic aneurysm * must be received open abdominal aortic aneurysm repair exclusion criteria: * age \>80 years old * acute coronary syndrome or myocardial infraction within * 3 months * chronic obstructive pulmonary emphysema * angina pain within 48 hours of repair procedure * ejection fraction less than 40% * poor pulmonary function (pao2 \<60mmhg) * history of inflammatory bowel disease * history of diarrhea (≥2 liquid stools per day for ≥2 days) within 1 week of surgery * intestinal chronic inflammatory disease

Keywords: aortic aneurysm ischemia/reperfusion preconditioning pulmonary injury intestinal injury
a study of bevacizumab (avastin) in combination with capecitabine (xeloda) in elderly patients with metastatic colorectal cancer

Conditions: Colorectal Cancer

Summary: this 2-arm study assessed the efficacy and safety of bevacizumab (avastin) in combination with capecitabine (xeloda), compared with capecitabine alone, in elderly patients with metastatic colorectal cancer. patients were randomized to receive either bevacizumab (7.5 mg/kg intravenously on day 1 of each 3-week cycle) in combination with capecitabine (1000 mg/m\^2 orally twice a day on days 1-14 of each 3-week cycle) or capecitabine (1000 mg/m\^2 orally twice a day on days 1-14 of each 3-week cycle) alone. no notable trends or interactions in laboratory values, electrocardiogram, or vital signs suggesting an effect in either direction for capecitabine/bevacizumab combination therapy or capecitabine monotherapy were observed during the study.


Eligibility criteria:
inclusion criteria: * adult patients, ≥ 70 years of age. * cancer of the colon or rectum. * metastatic disease diagnosed ≤ 6 months before enrollment. * ≥ 1 measurable metastatic lesion. exclusion criteria: * adjuvant anti-vascular endothelial growth factor (vegf) treatment. * prior chemotherapeutic treatment for metastatic colorectal cancer. * past or current history of other malignancies (with the exception of basal and squamous cell cancer of the skin, or in situ cancer of the cervix). * clinically significant cardiovascular disease. * current or recent daily use of aspirin (\> 325 mg/day) or other non-steroidal anti-inflammatory drug (nsaid), or full dose anticoagulants.
effects of oxytocin and lorazepam on fear-related intra-amygdalar activity

Conditions: Oxytocin, Lorazepam, Anti-Anxiety Agents, Physiological Effects of Drugs

Summary: high-potency benzodiazepines have strong anxiolytic effects accompanied by significant adverse effects including impaired cognitive function, drowsiness, dizziness and impaired motoric abilities. importantly, the long-term use of benzodiazepines may produce dependence and withdrawal. therefore, there is considerable scientific and public interest in identifying new anxiolytic agents. the hypothalamic peptide oxytocin (oxt) has anxiolytic effects both in healthy participants and patients with anxiety disorders by decreasing fear-associated amygdala activity. however, so far no human study has directly compared the underlying anxiolytic mechanisms of oxt and established anxiolytic agents on amygdala activity. importantly, the amygdala is not a homogenous structure but rather consists of several subdivisions with structural and functional differences. therefore, the rationale of the present project is to determine the effects of intranasal oxt and the high-potency benzodiazepine lorazepam on fear-associated responses in intra-amygdalar subregions.


Eligibility criteria:
inclusion criteria: * healthy male volunteers * right-handed exclusion criteria: * current or past psychiatric illness * current or past physical illness * psychoactive medication * sedative medication * mri contraindication (e.g. metal in body, claustrophobia)

Keywords: amygdala, anxiety, benzodiazepines, fear, fmri, lorazepam, oxytocin, 7 tesla
a study of epidural bupivacain-soaked absorbable gelatin sponge on post-operative pain in lumbar laminectomy

Conditions: Lumbar Laminectomy

Summary: the effective relief of pain is of paramount importance to anyone treating patients undergoing surgery. post-operative pain increases the possibility of post-surgical complications, raises the cost of medical care, and most importantly, interferes with recovery and return to normal activities of daily living. therefore pain control is essential in the management of patients undergoing spinal surgery.parenteral administration of narcotics has been the mainstay for postoperative pain relief in patients undergoing laminectomy and discectomy. epidural and intrathecal opioids are also effective means of pain control in several major surgical interventions including spinal surgery. however, some of the side effects have limited their widespread use (eg, late-onset respiratory depression). therefore, alternative measures of pain control including infiltration of paraspinal musculature with local anesthetics have been investigated with conflicting results. in situations such as laminectomies, where the epidural space is exposed as part of the surgical procedure, the application of absorbable gelatin sponge soaked in local anesthetics appears to be an alternative for providing postoperative analgesia. by investigating the probable analgesic effects of this method the investigators may relieve post laminectomy pain with minimal side effects and also costs.


Eligibility criteria:
inclusion criteria: * asa grade i or iii * scheduled to undergo lumbar laminectomy exclusion criteria: * patients who are younger than 18 years of age * pregnant * spinal or lateral stenosis * previous intervertebral disc surgery at that level * patients with history of chronicity (symptoms \>6 months duration) or coexisting medical conditions such as substance abuse or withdrawal, hyperthyroidism, anxiety disorder, affective disorder, hepatic or renal impairments
characteristics of clinical laboratory indicators in patients with dengue fever

Conditions: Dengue Fever

Summary: the objective of this observational study was to understand the changes in laboratory indicators and clinical manifestations of dengue patients at various ages, and to provide new ideas for the treatment and prevention of dengue. the main questions it aims to answer are: 1 what are the key abnormal items in blood routine indicators of dengue patients? 2 does dengue affect liver function in patients? will there be liver damage? and when? 3. what are the specific clinical manifestations of dengue patients?


Eligibility criteria:
* inclusion criteria\*\*: * meet the clinical diagnostic criteria for dengue fever, with blood indicators showing that the dengue antigen is positive. * no age limit for inclusion. * voluntarily agree to participate in the study and sign the informed consent. * complete clinical data available, including symptoms and laboratory tests, to support subsequent analysis. * exclusion criteria\*\*: * incomplete or unavailable clinical data. patients will be excluded if sufficient laboratory data and symptoms cannot be collected. * unable to understand or unwilling to sign the informed consent for any reason.
comparison of the efficacy of high-flow nasal oxygen therapy and facial mask ventilation on the increase of the oxygen reserve index during anesthetic induction

Conditions: Adult Patients 20 Years of Age or Older Who Are Planning to Undergo Surgery Under General Anesthesia

Summary: the purpose of this study is to compare the ability of oxygenation with high-flow nasal oxygen therapy and mask ventilation technique for induction of anesthesia in adult patients who are planning to undergo surgery under general anesthesia.


Eligibility criteria:
inclusion criteria: * adult patients aged over 19 years who are scheduled for sleep endoscopy exclusion criteria: * basal skull fracture * facial anomaly * consciousness disorder * risk of aspiration * necessity of awake fiberoptic intubation due to the large vocal cord mass, endotracheal tumor or bleeding.
methacholine challenge: comparison of doubling and quadrupling methacholine dose regimes using the tidal volume method

Conditions: Asthma

Summary: the purpose of this study is to determine the difference (if any) in the result of the methacholine challenge (a test used by physicians in diagnosing asthma) when concentrations of methacholine are quadrupled versus doubled.

the purpose of this study is to confirm that the tidal volume technique of methacholine delivery may be employed in methacholine challenges using a quadrupling dose schedule instead of the standard doubling dose schedule with similar diagnostic efficacy, with no increase in patient adverse events, and with a shorter investigational duration. this has previously been shown to be true using the dosimeter technique of methacholine challenge.

Eligibility criteria:
inclusion criteria: * you must be over 18 years of age; and * you must have a diagnosis of asthma; and * excluding asthma, you are not aware of any other lung conditions or diseases. exclusion criteria: * you have a known hypersensitivity (i.e. an overreaction of your immune system) to methacholine or other parasympathomimetic agents or cholinesterase inhibitors (i.e. agents that act in a similar way via your nervous system - to be discussed with study personnel); or * you are a nursing mother or if you are a woman of child bearing potential who is, may be, or intends to become pregnant during testing as the effects of methacholine inhalation in these situations are not known; or * your baseline lung function is poor (ie. your fev or forced expiratory volume in one second, is less than 65% of your predicted values). this will be performed and explained by study personnel prior to commencing methacholine inhalation testing; or * you have had any respiratory infections for the last four weeks; or * if you have allergies, and have been exposed to agents that trigger your asthma within the last four weeks; or * if you have any significant chronic medical condition.
the anticariogenic effect of miswak (silvadora persica) and grape seed extract

Conditions: Dental Caries

Summary: prevention of dental caries has taken a great importance in the last decade. the use of herbal and natural products became mandatory to avoid the side effects of commercially available medications. aim of the study; the aim was to investigate the anti-cariogenic effect of miswak and grape seed extract (gse).

patients used miswak sticks, grape seed extract mouth wash and fluoride mouthwash twice daily for three month. saliva samples were collected at base line and after one month and three month. assessment of bacterial count and saliva buffering capacity were performed at base line and after one and three month.

Eligibility criteria:
inclusion criteria: * patients with high caries risk * males or females * medically free patients * patients approving to participate in the study exclusion criteria: * patients who were on antibiotic therapy or corticosteroid therapy for 30 days before the examination * patients had history of professional cleaning in the last 15 days * patients with exposed pulp * evidence of parafunctional habits * patients with developmental dental anomalies * patients undergoing or will start orthodontic treatment * patients with removable prosthesis * periapical abscess or fistula
steps for prostate cancer health and survival (spartacus): pilot study of a walking intervention to improve health and quality of life in prostate cancer patients

Conditions: Prostatic Neoplasm

Summary: the purpose of this study is to determine whether sustainable daily physical activity is effective in improving biological indicators of health and self-reported quality of life in men with prostate cancer.

living with prostate cancer is a unique challenge faced by millions of men across the globe. existing research has indicated many potential methods of attenuating prostate cancer progression and preserving patients' quality of life, but is lacking in definitive conclusions regarding the effectiveness of these methods in practice. this study seeks to further investigate the impact of post-diagnosis physical activity on biological indicators of health and self-reported quality of life in a cohort of men with prostate cancer in sweden. participants are randomized to either a walking intervention group, which encourages walking 10,000 steps per day for one year, or to a standard-or-care control group, and followed for 11 weeks.

Eligibility criteria:
inclusion criteria: * age 80 years or younger * histologic confirmation of prostate cancer * clinically or pathologically staged as locally advanced or early metastatic prostate cancer * diagnosis within 1 year of study enrollment * willing and able to walk 10,000 steps per day exclusion criteria: * age greater than 80 years old at enrollment * inability to understand the language spoken in host country * physically unable to walk 100 meters unassisted * diagnosed with dementia or severe psychiatric disease * any prior cancer diagnosis * has experienced a myocardial infarction or stroke within six months of cancer diagnosis

Keywords: prostate cancer
selective motor control and upper extremity functions in children with hemiparetic cerebral palsy

Conditions: Cerebral Palsy

Summary: identification of musculoskeletal and neuromuscular factors that affect the integrity and functional performance in children with cerebral palsy is very essential as it enables multidisciplinary rehabilitation team to design the proper intervention to improve functional performance and independence for those children.

limited literature is available regarding the relation between selective voluntary motor control and motor functions in children with cerebral palsy. up to our knowledge this is the first study intending to investigate the influence of selective voluntary motor control on upper extremity function in children with spastic cerebral palsy. therefore, the current study will be conducted to investigate the correlation between selective voluntary motor control and upper extremity functions in children with spastic hemiparetic cerebral palsy. it is hypothesized that:- 1. there is no relation between svmc and upper limb function in children with spastic hemiparetic cp. 2. there is no relation between upper extremity svmc and hand grip strength in children with spastic hemiparetic cp.

Eligibility criteria:
inclusion criteria: * age ranges from 4 to 8 years. * both genders. * diagnosis of spastic hemiparetic cerebral palsy. * level i-iv on manual ability classification system. * spasticity grade 1 to 2 on modified ashworth scale. * level i-iii on gross motor classification system . exclusion criteria: * significant mental or psychological problems. * significant visual/auditory problem. * botox injection and/or surgery of the upper limb in the past 12 months. * fixed deformities in the affected upper extremity.

Keywords: cerebral pals selective voluntary motor control upper extremity function hand grip strength
comparison between m-pro and protaper next

Conditions: Symptomatic Irreversible Pulpitis

Summary: comparing the postoperative pain resulting after mechanical instrumentation using m-pro files versus that resulting after using protaper next rotary files in lower molar with symptomatic irreversible pulpitis molars.

lower molars with symptomatic irreversible pulpitis molars are selected according to the eligibility and exclusion criteria and patients are then randomized to receive treatment either using m-pro files or protaper next files. postoperative pain is then assessed using the numerical rating scale 6, 12, 24, 48 and 72 hours post-operatively . after completing the treatment, patients will instructed to take placebo if they feel pain and will be asked to provide the quantity of placebo intake until 72 hrs. in case of pain not relieved by placebo, after recording the amount of pain, the patient will be instructed to take an alternative line of pain control (ibuprofen 400mg tablets every 6 hours). the amount and frequency of ibuprofen intake will be recorded.

Eligibility criteria:
inclusion criteria: * 1- males or females. * 2- mandibular molar teeth with: * pre-operative sharp pain. * vital response of pulp tissue to cold pulp tester (ethyl chloride spray). * normal periapical radiographic appearance or slight widening in lamina dura using periapical index (pai) score 1 as normal periapical structures or 2 as small changes in bone structures. exclusion criteria: * patients having significant systemic disorders. * patients who are allergic to non-steroidal anti-inflammatory drugs. * patients with two or more adjacent teeth requiring root canal therapy. * teeth that have: * necrotic pulp tissues. * association with swelling or fistulous tract. * acute or chronic peri-apical abscess. * greater than grade i mobility. * pocket depth greater than 5mm. * no possible restorability. * previous endodontic treatment.
an observational study to assess the burden of drug-resistant partial epilepsy in italy

Conditions: Epilepsy, Partial

Summary: observational, non-interventional study in 120 patients with drug-resistant partial epilepsy, comprising two phases: a 3-month retrospective and a 6-month prospective. as control group, 120 patients with controlled partial epilepsy will be enrolled. the objective of the study is to describe the burden of illness in this epileptic population both in terms of costs and of quality of life. costs and quality of life will be also compared between the two populations.

observational, non-interventional study in 120 patients with drug-resistant partial epilepsy, comprising two phases: a 3-month retrospective and a 6-month prospective.

Eligibility criteria:
inclusion criteria: * outpatients * diagnosis of partial epilepsy, defined as active, drug-resistant in accordance to the 2010 ilae (international league against epilepsy) definition and actually taking an add-on therapeutic regimen. * able and willing to give the written informed consent (to be obtained before any study assessment) for each drug-resistant patient, will be enrolled a patient with the same diagnosis and actually taking an add-on therapy but with controlled epilepsy according to the 2010 ilae definition. exclusion criteria: * patient currently included in a clinical trial for an aed (anti-epileptic drug) * hospital record data on epilepsy not available in the investigator's files * patient unable to fill in self-questionnaires (quality of life instrument) * patient currently hospitalized * patient who, according to the investigator's judgment, is not able to follow the study procedures