Kornimate/medical-research-clean huggingface dataset:
response to sars-cov-2 vaccine in stem cell transplant and cellular therapy patients

Conditions: Hematologic Disorders and Bone Marrow Failure, Hematopoietic Stem Cell Transplantation (HSCT) or Cellular Therapy (CART)

Summary: for many patients with hematologic disorders and bone marrow failure, hematopoietic stem cell transplantation (hsct) or cellular therapy (cart) offers a curative treatment option. patients after sct or cart have a variable period of immune deficiency in the post-treatment period. the response to vaccination may affect the outcome of the transplant patients. the immunogenicity of vaccines in this immunosuppressed population is uncertain and variable. hsct and car-t recipients are in a covid-19 high-risk group and conferring immunity by vaccination at the earliest effective timepoint is desirable. at present, the immunogenicity and efficacy of sars-cov-2 vaccines in immune-impaired patients including autologous and allogeneic hsct recipients is unknown. furthermore, the impact of gvhd and ist on sars-cov-2 vaccine immunogenicity is unknown. the investigators aim to evaluate the vaccination response to covid vaccines after sct and cart

so for participants with sct or cart who decide to get their vaccines, the investigators will measure response by therapy by measuring covid-19 serology igg at the following schedule: baseline +5 days after vaccination; 1 month +/- 10 days (after the first dose), 2 months +/- 10 days (after the 2nd dose), 3 months +/- 10 days, 6 months +/- 10 days and 12 months +/- 10 days in addition, also the investigators will collect cd4 and total igg which is the standard of care of these patients post sct and cart

Eligibility criteria:
inclusion criteria: * any sct or cart post covid vaccine exclusion criteria: * none

Keywords: vaccine
communication bridge 2

Conditions: Primary Progressive Aphasia

Summary: this study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild primary progressive aphasia (ppa). the aim of the study is to help us better understand the effects of speech language therapy on communication abilities in individuals with ppa. participants with a diagnosis of ppa and their actively-engaged care partners will be involved in the study for 12 months. each participant will receive a laptop equipped with the necessary applications and features for the study. participants will receive 5 evaluations and 15 speech therapy sessions with a licensed speech therapist, as well as access to communication bridge, a personalized web application to practice home exercises that reinforce treatment strategies. there are no costs to participate in this study.


Eligibility criteria:
inclusion criteria (person with ppa): 1. meets diagnostic criteria for ppa based on neurologist and supporting medical assessments (extracted from medical records) 2. english as primary language used in daily communication activities (by self-report) 3. adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report) 4. adequate vision (aided or unaided) for reading a newspaper, or other functional materials (by self-report) 5. able to pass technology screening and demonstrates sufficient knowledge for use of video conference and communication bridge™ web application use (with or without training) 6. geriatric depression scale score ≤ 9 7. mild-moderate ppa informed by a structured interview with a speech-language pathologist and a standardized testing battery. inclusion criteria (co-enrolled communication partner): 1. 18+ years of age 2. english as primary language used in daily communication activities (by self-report) 3. adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report) 4. able to pass technology screening\* and demonstrates sufficient knowledge for use of video conference and communication bridge™ web application use (with or without training) exclusion criteria: * a dementia diagnosis other than primary progressive aphasia * participation is co-enrolled in an outside speech language therapy program during the study course. * communication partners will be excluded if they have a pre-existing communication impairment that would affect study participation (e.g., aphasia, dementia) medical records will be requested and reviewed to determine eligibility.

Keywords: aphasia primary progressive aphasia dementia communication frontotemporal dementia alzheimer's disease
brief interventions in general hospital (big)

Conditions: Alcoholism

Summary: alcohol abuse is a widespread concern internationally with a significant threat to world health. research suggests a relationship between heavy drinking and certain clinical presentations such as injuries, physical and psychiatric illnesses and frequent sickness absence from employment. this research aims to establish whether brief interventions delivered to harmful and hazardous alcohol drinkers admitted to hospital impacts of their alcohol consumption levels on discharge from hospital.

purpose to evaluate the effectiveness of brief interventions for hazardous and harmful alcohol abusers admitted to medical and surgical wards at the southern general hospital evidence for brief interventions in general hospital further research is required to prove the benefits of brief interventions within general hospital, based on evidence from the cochrane systematic review 'brief interventions for heavy alcohol users admitted to general hospital wards' (mcqueen et al 2009). links with national and international agendas the european health target12 supports a reduction in harm from alcohol drugs and tobacco. by the year 2015 the adverse health effects from the consumption of addictive substances such as alcohol should be reduced by all member states (european health for all targets 1998) the scottish government has set heat (health improvement, efficacy and governance access and treatment) target for the nhs to deliver 149,449 alcohol brief intervention cumulatively over the period of 2008/9-2010/11 (scottish alcohol and drugs workforce 2008). research design this study will employ a randomised control trial design. the primary outcome measure will be grams of alcohol consumed per week, measures will be taken at baseline, six months and one year post intervention. secondary outcomes will consist of brief intervention's impact on hospital re-admission rates, attendance at a\&e and mortality rates.

Eligibility criteria:
inclusion criteria: * scores between 3-12 on fast * admitted to hospital * speaks english exclusion criteria: * under 18 years * cognitively impaired * medically unfit

Keywords: alcohol brief interventions counseling harmful/hazardous alcohol drinkers
various strategies to reduce acute post hemorrhoidectomy pain: a comparative study

Conditions: Acute Post Operative Pain

Summary: since post hemorrhoidectomy pain is a severe and common post operative symptom so there is a need to find a suitable method for reducing this pain, up to our knowledge, this the first study in zuh to compare between ketrolac, light marcaine, corticosteroids and diclofenac sodium injection at surgical site for relieve of post operative pain. this is a randomized controlled comparative prospective clinical trial.


Eligibility criteria:
inclusion criteria: * both sex. * age from 18 to 60. exclusion criteria: * patient refusal. * patients with associated ano-rectal diseases such as fissures, fistulas, ano-proctitis, recurrent or thrombosed hemorrhoids and ano-rectal malignancy. * patients with liver cell failure. patients unfit for surgery according to american society of anesthesiologists.

Keywords: hemorrhoidectomy acute pain corticosteroids
safety of pregnancy in brca mutated breast cancer patients

Conditions: Breast Cancer

Summary: the present study aims at refining the understanding of the effect of pregnancy on breast cancer outcomes in the specific population of brca mutated patients with known history of breast cancer.


Eligibility criteria:
inclusion criteria: * diagnosis of invasive breast cancer between january 2000 and december 2020; * breast cancer diagnosis at the age of ≤ 40 years; * known presence of germline brca mutation. exclusion criteria: * known brca mutation with no diagnosis of invasive breast cancer; * diagnosis of ovarian cancer or other malignancies with no history of invasive breast cancer; * diagnosis of hereditary or familiar invasive breast cancer without brca mutation or with brca genes not tested; * diagnosis of invasive breast cancer with germline brca variants of unknown significance.

Keywords: breast cancer brca young survivorship
comparing insulin aspart with fast-acting insulin human in subjects with type 1 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1

Summary: this trial is conducted in japan. the aim of the trial is to compare pharmacokinetics (at which rate the body eliminates the substance from the body) of insulin aspart with fast-acting insulin human following intravenous (iv) infusion or intramuscular (im) injection in japanese subjects with type 1 diabetes mellitus.


Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus (as diagnosed clinically) for at least 12 months * treated with multiple daily insulin injections for at least 12 months * current daily basal insulin requirement above or equal to 0.3 u/kg/day * glycosylated haemoglobin a1c (hba1c) below or equal to 10.0% * body mass index (bmi) 18.0-28.0 kg/m\^2 exclusion criteria: * subject who has donated any blood or plasma in the past month or more than 500 ml within 3 months prior to trial start (screening) * surgery or trauma with significant blood loss (more than 500 ml) within 3 months prior to trial start (screening) * subject who smokes more than 10 cigarettes or the equivalent per day * not able or willing to refrain from smoking and use of nicotine gum or transdermal nicotine patches during the inpatient period
effect of qva149 (indacaterol maleate/glycopyrronium bromide) on cardiac function in copd patients

Conditions: Chronic Obstructive Pulmonary Disease, COPD

Summary: this mechanistic study is a single-center, randomized, double-blind, placebo-controlled, cross-over study to evaluate the effect of dual bronchodilation with qva149 on cardiac and lung function parameters in hyperinflated copd patients.


Eligibility criteria:
inclusion criteria: * patients with airflow limitation indicated by a post-bronchodilator fev1 \<80% of the predicted normal value and a post-bronchodilator fev1/fvc\<0.7 * current or ex-smokers who have a smoking history of at least 10 pack years. * able and willing to give written informed consent * hyperinflated patients with rvol\>135% predicted exclusion criteria: * patients on laba or lama treatment at visit 1. * history of one copd exacerbation that required treatment with antibiotics, systemic steroids (oral or intravenous) or hospitalization 3 months prior to visit 2. * more than one copd exacerbation that required treatment with antibiotics, systemic steroids (oral or intravenous) or hospitalization within 6 months prior to visit 2. * patients who have clinically significant cardiovascular abnormalities, which could interfere with the assessment of the study treatment (such as but not limited to cardiac arrhythmias, heart failure with left ventricular ejection fraction \<40% as determined by mri scan, unstable ischemic heart disease, nyha class iii/iv left ventricular failure, history of myocardial infarction 6 months prior to visit 2) * patients with a known history or current atrial fibrillation to be confirmed by ecg. * patients with pacemaker, bypass or stent. * patients whose qtcf measured at visit 3 is \>450 ms for males and \>470 ms for females additional study-specific inclusion and exclusion criteria may apply

Keywords: qva149, cardiac function, ventricular enddiastolic volume, hyperinflated copd patients
effects of sub occipital muscle inhibition technique in mechanical low back pain

Conditions: Mechanical Low Back Pain

Summary: the aim of study is to determine the effects of sub occipital muscle inhibition technique in mechanical low back pain, hamstring muscle flexibility, lumbar ranges and functional disability. this study will focus on either this technique have effects on reliving lumbar pain, improving flexibility of hamstring muscles and lumbar ranges or not.

low back pain (lbp) is a common health condition, 70% of population of all ages is suffering from low back pain. females have higher prevalence of low back pain than males. individuals with low back pain experience muscle stiffness tension and pain in the back of body between the lower edge of 12th rib and the lower border of gluteal creases in the lumbo-sacral area (from l1-s1 vertebra) with a duration of more than three months. low back pain can be mechanical in nature and is not associated with any other pathology .the primary etiological factors of mechanical low back pain is repetitive trauma and overuse. hamstring is a multi - joint muscle complex which consists of three muscles ( semitendinosus, semimembranosus and biceps femoris muscle) that covers the posterior thigh extending from ischial tuberosity to the medial and lateral aspects of the knee joint, performing flexion of knee and extension of hip joint. hamstring muscle is prone to tightness, its flexibility have a vital role in maintaining the normal lumbar spine mechanics. hamstring tightness is common among ages of 18-25 years with about 62% to 82% prevalence .hamstring shortening during spinal flexion limits anterior pelvic tilting resulting in higher compressive loads on lumbar spine. it will place extreme pressure on lumbar extensors, involved in maintaining pelvic motion which will result in lbp . sub occipital muscle inhibition technique is a technique that results in relaxing the tense fascia and sub occipital muscles .it can be relaxed by applying pressure to sub occipital region while patient is lying in supine position. it is able to relax the fascia and results in increasing hamstring flexibility, which further results in reducing low back pain, increasing lumbar spine mobility and reducing functional limitations

Eligibility criteria:
inclusion criteria: * chronic mechanical low back pain \> 12 weeks * patients with hamstring tightness having popliteal angle more than 30 degrees. * negative sacroiliac distraction test to exclude sacroiliac joint pain exclusion criteria: * acute severe low back pain * patients with hamstring injury * active tumor or infection * fractures of cervical and lumbar spine * history of previous lumbar, hip and knee surgery * migraine * fever * sacroiliac joint dysfunction * cauda equine syndrome * patients having cognitive or mental retardation

Keywords: mechanical low back pain sub occipital muscle inhibition hamstring flexibility
biomarkers trajectories of early intervention in siblings of children with autism spectrum disorder

Conditions: Autism Spectrum Disorder; Early Intervention

Summary: this project deals with essential challenges in the context of autism spectrum disorder benefiting from a prospective design in childhood, early intervention and a cutting-edge experimental techniques. the present study tests the potential effect of early intervention on neural and behavioral responses in toddlers at elevated likelihood of developing autism (siblings of children with autism) who show clinical autistic signs. four comparison groups were included in the study: (1) toddlers at elevated likelihood of developing autism with clinical autistic signs who receive early intervention from 18 to 24 months (2) toddlers at elevated likelihood of developing autism with clinical autistic signs who do not receive early intervention (3) toddlers at elevated likelihood of developing autism without clinical autistic signs who only received assessment and monitoring, and (4) typically developing toddlers who only received assessment and monitoring. this study focuses on social and nonsocial sensory integration skills (measured by electroencephalographic and eyetracking recordings) to identify reliable biomarkers for early detection and intervention of autism during a critical period of development. the characterization of biomarkers will guide the detection of the most vulnerable children that will benefit from early intervention, with the long-term aim of reducing the impact of autism on the national health system.


Eligibility criteria:
inclusion criteria: * toddlers aged between 18 and 24 months * toddlers at elevated likelihood of developing autism, because siblings of children with a diagnosis of autism (for group 1, 2, and 3) exclusion criteria: * gestational age \<36 weeks and/or birthweight \< 2000 grams * griffiths general quotient at 18 months \< 70 * presence of major complications in pregnancy and/or delivery likely to affect brain development * presence of neurological deficits, dysmorphic markers, or other medical conditions.

Keywords: siblings autism biomarkers early intervention
mirror box imaging study

Conditions: Stroke

Summary: the purpose of this study is to evaluate the effects of mirror box therapy on upper extremity, motor recovery and motor functioning in patients that have suffered a stroke.

arm and hand weakness as a result of stroke occurs in approximately 70% of stroke survivors, with 30%-60% of patients being unable to fully recover functional use of their upper limbs. as recovery may be due to insufficient or inadequate therapeutic interventions, the progress and evaluation of upper limb treatment is currently being investigated. mirror box therapy is a task orientated, non-invasive, economic and patient directed therapy for hemiparetic upper limb post stroke patients. the study is intended to evaluate cerebral reorganization by using mirror therapy. movements of the stronger limb trick the brain into thinking that the weaker arm is moving and to stimulate the respective brain areas. patients are enrolled into two groups using standard upper limb rehabilitation for three weeks followed by standard rehabilitation plus mirror box for another three weeks (group 1). group 2 will receive the same therapy in inverted order. patients will receive clinical and functional assessment at baseline, three weeks and six weeks including brain mri using functional resting state mri. the primary outcome is functional connectivity (correlation coefficient) at baseline and after treatment. secondary endpoints include motor and functional recovery using outcome measures like fugl meyer assessment, action research arm test, grip and pincer strength. further secondary endpoints are increase in sensorimotor cortex activation across the period of therapy and cortical reorganization.

Eligibility criteria:
inclusion criteria: * 18yrs to 105yrs * hemiparetic upper limb post stroke * capable of providing informed consent * intact vision: if diagnosis of peripheral field defect, patient should be able to compensate for it. exclusion criteria: * any contraindication to mri scanning * clinically significant psychiatric disorder (e.g. depression) * pre-existing neurological or psychiatric disease that could confound the study results.
the role and intervention of tgf-β in abdominal radiation injury

Conditions: Radiotherapy Side Effect; Taking Captopril

Summary: this project aims to investigate the relationship between radiation-induced the relationship between elevated peripheral blood tgfβ and complications of radiotherapy,and to analysis of changes in peripheral blood tgfβ levels after abdominal radiotherapy and its relationship with radiotherapy complications.simultaneously,patients who underwent abdominal radiotherapy were given captopril (sustained release) to block tgfβ,whether it can reduce peripheral blood tgfβ levels and reduce radiotherapy complications,to explore the protective effect of blocking tgfβ secretion on normal tissues after radiotherapy.


Eligibility criteria:
inclusion criteria: 1. informed consent form for this study has been signed 2. age 18-70 years old, gender is not limited，pathological diagnosis of patients with advanced malignant tumors，radiotherapy indications； 3. bed (α/β=10)≥50；ecog score 0-2；blood routine：wbc≥3.5×109/l,gran≥2.0×109/l,hb≥90g/l，plt≥100×109/l; 4. liver function: alt or ast ≤ 2.5 times the normal high value (uln)；bilirubin ≤ 1.5 × uln, serum apk ≤ 2.5 × uln; 5. renal function：serum creatinine ≤1.5×uln, and creatinine clearance ≥60ml/min 6. no organ transplant history 7. women of childbearing age must undergo a urine pregnancy test within 7 days prior to initiation of treatment and the results are negative and not in lactation 8. male and female patients of childbearing age agreed to adopt a reliable method of contraception before entering the trial and during the study until 30 days after stopping the drug. exclusion criteria: 1. patients undergoing chemotherapy or targeted therapy at the same time 2. long-term use of acei or arb drugs for hypertension 3. this radiotherapy site has been treated with radiotherapy；combined with severe heart disease or major organ failure 4. have a history of drug abuse or alcohol addiction 5. combined active infection 6. combined with severe malnutrition or severe anemia 7. human immunodeficiency virus (hiv) infection 8. during pregnancy or lactation 9. those who are unable to tolerate or may be allergic to the drugs used in this study；persons without civil capacity or limited capacity for civil conduct； 10. researchers believe that it is not suitable for inclusion
(sbrt) and (art) for pulmonary metastases from soft tissue sarcomas

Conditions: Stage IV Adult Soft Tissue Sarcoma; Sarcoma,Soft Tissue

Summary: this is a prospective study to document the local control rates with sbrt specifically for pulmonary metastases from soft tissue sarcoma. this study will prospectively document acute and late toxicity, quality of life (qol), tumor control, and survival.

a total of no more than 20 people are expected to participate in this study at the medical college of wisconsin/froedtert hospital. patients will be followed for three years. the usual treatment for sarcomas that spread to the lungs is to remove the cancer with surgery. patients who cannot have surgery or prefer not to have surgery, can receive radiation therapy. standard radiation therapy involves several weeks of daily treatment sessions, although it is not as effective as surgery and may seriously damage normal surrounding lung tissue. stereotactic body radiation therapy (sbrt) is a radiation treatment that gives fewer but higher doses of radiation than standard radiation. sbrt is used to treat metastases to the lung from many types of cancer but has not been used very often with patients who have metastatic disease to their lungs from sarcomas. the purpose of this study is to test the possibility of sbrt to the lung for metastatic disease to the lung. this information will be used to find out if there are factors that can predict recovery or outcome of patients with metastatic disease to the lung from sarcoma. sbrt will consist of 1 to 3 treatments per week for a total of 3 to 5 treatments to each tumor until therapy is complete. after sbrt is completed, follow-up exams will occur 4-6 weeks from the completion of radiation treatment, every 3 months in year 1 and every 6 months for 2 years.

Eligibility criteria:
inclusion criteria: * ≥18 years of age * pathologic confirmation of primary soft tissue sarcoma with pathologic or radiographic evidence of pulmonary metastatic disease * no evidence of extra pulmonary progression of disease for 3 months prior to enrollment on study * 1-5 pulmonary lesions all ≤5 cm in size * medically inoperable or declines surgery * patients may have had previous treatment for pulmonary metastases exclusion criteria: * patients who have uncontrolled extra-pulmonary disease * pregnant women * patients who have greater than 5 pulmonary lesions at the time of study enrollment * patients who have disease progression outside the lungs within 3 months of enrollment on the study * disease pathology other than sarcoma subtypes * patients with a history of metastatic disease from a primary other than sarcoma

Keywords: lung metastases radiation therapy stereotactic body radiation therapy sarcoma