Kornimate/medical-research-clean huggingface dataset:
retrospective analysis of chest x-ray severity scoring system of covid-19 pneumonia

Conditions: COVID-19 Pneumonia; Sepsis; SARS-CoV-2 Acute Respiratory Disease; Pneumonia; Multiorgan Failure

Summary: the research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the covid-19 icu of university hospital center osijek due to pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2). the association of chest x-ray infiltrate evolution with changes in laboratory inflammatory parameters and respiratory function parameters will be examined.

the research will be retrospective, and will include a review of medical history of all patients admitted in the covid-19 icu of the university hospital osijek during 2020 and 2021. associated comorbidity, hospital admission date, intubation date, mechanical ventilation, extubation, discharge, and patient final outcome will be recorded for each patient. by analyzing x-rays of the lungs by radiology specialists, inflammatory infiltrates in the lungs will be quantified via the brixia system, during hospital admission, admission to the respiratory center, and during treatment at the respiratory center. all patients will have their sequential organ failure assessment (sofa) and/or acute physiology and chronic health evaluation (apache ii) values calculated upon admission. inflammatory parameters (c-reactive protein (crp), procalcitonin (pct), interleukine-6 (il-6), ferritin), red blood cell count, leukocytes, blood urea nitrogen (bun), arterial blood gases and ventilation parameters on admission to the hospital, admission to the icu, and on several occasions during treatment in the icu will be analysed. also, empirical use of antibiotics, the occurrence of bacterial superinfections, sepsis and organic failure will be noted.

Eligibility criteria:
inclusion criteria: * pneumonia caused by sars-cov-2 virus * admission to the icu covid-19 unit exclusion criteria: - patients with lung tumors or history of lung resection

Keywords: covid-19 acute respiratory distress syndrome (ards) sepsis multiorgan failure chest x-ray inflammation
long-term side effects of ruxolitinib in treating patients with myelofibrosis

Conditions: Myelofibrosis

Summary: this phase ii trial studies the long-term side effects of ruxolitinib in treating patients with myelofibrosis. collecting data about the long-term safety and tolerability of ruxolitinib may better help future patients with myelofibrosis.

primary objectives: i. to collect long term safety and tolerability data in patients with myelofibrosis previously treated with ruxolitinib on protocol 2007-0169. outline: patients continue to receive ruxolitinib orally (po) once daily (qd) or twice daily (bid). cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. patients undergo follow-up assessment for safety over 10 minutes every 3 cycles.

Eligibility criteria:
inclusion criteria: 1. currently enrolled in study 2007-0169 and benefiting from therapy as determined by treating physician 2. eastern cooperative oncology group (ecog) performance status of 0, 1, or 2 at enrollment of this study 3. ability and agreement to attend protocol-specified visits at the study site 4. able to comprehend and willing to sign the informed consent form 5. negative pregnancy test in females of childbearing potential; male patients with female partners of child-bearing potential and female patients of childbearing potential are required to use two forms of acceptable contraception, including one barrier method, during their participation in the study and for 30 days following last dose; acceptable forms of contraception include 1 highly effective method such as an intrauterine device (iud), hormonal (birth control pills, injections, or implants), tubal ligation, or partner's vasectomy and at least 1 additional approved barrier method such as a latex condom, diaphragm, or cervical cap; female patients of childbearing potential must not be breast-feeding or planning to breast feed and must have a negative pregnancy test 7 days before first study treatment exclusion criteria: 1. none
macroscopic and molecular changes in knee muscular-tendon unit in response to acute resistant load

Conditions: Quadriceps Muscle

Summary: the aim of this study is to determine the influence of acute resistance exercises on anatomical and biological changes in the quadriceps muscle and tendons of the knee


Eligibility criteria:
inclusion criteria: * non-professional athletes * pass heart/lung endurance tests * pass ergometrics testing exclusion criteria: * have been injured * had physiotherapy for back or lower limbs in past 6 months * orthopedic surgery in lower limbs
virtual prehab study for patients undergoing tavi

Conditions: Cardiovascular Diseases in Old Age; Frailty; TAVI

Summary: nova scotians are aging and many are becoming frailer. people with frailty are more likely to live in worse health and do not recover well from major events, such as open heart surgery. many people are also too frail to receive open heart surgery. less invasive procedures called transcatheter aortic valve implantation, or tavi, are provided for the frailest patients. while tavi is life-saving, frailer patients are less likely to survive in better health after their operation. patients in nova scotia can also wait up to 3-6 months for their operation where they become frailer or can die before receiving tavi. the investigators believe that it is important to support these individuals to improve their frailty and overall health before their operation. center-based cardiac rehabilitation is offered to patients after, but not before tavi to improve their health. center-based preoperative cardiac rehabilitation (i.e., prehab) can safely improve the function of frail patients who received open heart surgery. however, many patients cannot come to a center-based prehab because of transportation requirements to access the program. another option is to support these patients with virtually delivered prehab, where they can stay in their homes. however, this possibility has not been studied. for this study, virtual prehab will be delivered using the virtual cardiac rehabilitation program in nova scotia to patients before tavi. this intervention will be delivered by healthcare providers who routinely care for tavi patients, including a medical director, program lead, nurse, physiotherapist, and dietician. ther goal of this study is to determine if it is feasible and safe to use virtual prehab to reduce frailty before tavi. this research fits with research nova scotia's priorities to improve patient outcomes in those with significant long-term health conditions, and to provide accessible, safe, and quality virtual healthcare to patients so they can thrive after their operation.


Eligibility criteria:
inclusion criteria: * outpatients attending the tavi clinic at the queen elizabeth ii health sciences centre * informed written or verbal consent exclusion criteria: * new york heart association or canadian cardiovascular score of 4 * severe functional limitations * cognitive impairment that impacts consenting ability * significant language barrier * no internet or telephone access that precludes virtual prehab participation

Keywords: frailty virtual prehab cardiac rehabilitation tavi
self-management for people with epilepsy and a history of negative health events

Conditions: Epilepsy

Summary: this is an investigation of adult individuals with epilepsy, and involves educational and behavioral interventions intended to enhance treatment adherence and self-management. the investigators are adapting a self-management intervention that they developed in a previous study to individuals with epilepsy and a history of negative health events (nhes), such as accidents and emergency department (ed) visits, diminished quality of life and poor mental well-being. the intervention "self-management for people with epilepsy and a history of negative health events (smart)" is intended to reduce nhes and improve quality of life in people with epilepsy associated with historically disadvantaged groups.


Eligibility criteria:
inclusion criteria: * diagnosis of epilepsy * negative health event within the last 6 months * able to provide written consent and participate in study procedures exclusion criteria: * immediate risk of self-harm * dementia * pregnancy * unable to read/understand english
alerta alcohol. web-based computer-tailored intervention for binge-drinking prevention in spanish adolescents

Conditions: Alcohol Drinking; Binge Drinking; Adolescent Behavior

Summary: this study consists in the the design, implementation, and evaluation of the first web-based computer tailored intervention program aimed at the prevention of binge drinking in spanish adolescents (alerta alcohol). a cluster randomized controlled trial is conducted to test the effectiveness of alerta alcohol in students aged 16 to 18 years across 16 high schools from andalusia (southern spain), which are randomized either to the experimental or the control condition (ec and cc).

binge-drinking in adolescents is a highly prevalent healthcare problem that associates physical and mental health complications and community implications. the "alerta alcohol" program is based on the i-change model. focus and delphi groups are used to obtain further information on items included in the program. a pilot study is conducted to identify strengths and weaknesses. a cluster randomized controlled trial is carried out. the schools from andalusia are randomized either to the experimental or the control condition (ec and cc). the ec receives the alerta alcohol intervention, which consists of four sessions at school: baseline questionnaire and two sessions where adolescents are provided with answers related to their views to provide highly specific feedback regarding their knowledge, risk perception, self-esteem, attitude, social influence, and self-efficacy. in addition, two booster sessions are given at home to reinforce the contents. the cc just completes the baseline and the evaluation questionnaires and then they are allowed to receive the intervention as well (as a waiting list control condition). evaluation takes place after four months. the primary endpoint is binge drinking within 30 days prior to evaluation and alcohol use in the previous week. it is expected that alerta alcohol reduces the prevalence of binge drinking by 10%. follow up analyses are carried out to determine the differences in effectiveness according to the compliance of the program (quality of the implementation).

Eligibility criteria:
inclusion criteria: * students aged 16 to 18 years. * enrolled in andalusian public high schools. * schools belonging to provincial capitals. * access to the internet at the school and an equipped ict room. exclusion criteria: * language barriers. * previous participation in prevention programs for binge drinking.

Keywords: adolescence alcohol drinking binge drinking i-change model web-based interventions computer-tailoring
the application of gastric bypass stents in patients with weight regain after laparoscopic sleeve gastrectomy：a feasibility study

Conditions: Obesity and Obesity-related Medical Conditions; Weight Regain

Summary: this study is based on the national center for integrated traditional chinese and western medicine, utilizing the centralized advantages of our department and integrating multiple disciplines (general surgery, endocrinology, nutrition, sports, and traditional chinese medicine). it focuses on the effectiveness of gastric bypass stents in treating patients with postoperative obesity after laparoscopic sleeve gastrectomy, as well as in patients with simple obesity. this will improve the prognosis of patients and reduce the medical burden.


Eligibility criteria:
inclusion criteria: * 1、for those with simple obesity, bmi ≥ 32.5, or 27.5 ≤ bmi \< 32.5, who have difficulty controlling their condition with lifestyle modifications and medical treatment, and who meet at least two criteria for metabolic syndrome components, or have comorbidities. 2、for those with simple obesity, 27.5 ≤ bmi \< 32.5, and with male waist circumference ≥ 90 cm, female waist circumference ≥ 85 cm, and imaging studies suggesting central obesity. 3、for those with type 2 diabetes, bmi ≥ 27.5, who still have some residual insulin secretion capacity. exclusion criteria: * 1、non-obese type 1 diabetes; 2、those for whom the purpose of treatment is t2dm, but whose pancreatic beta-cell function is largely lost, with a bmi \ 65 years; 4、pregnant women with diabetes and patients with certain special types of diabetes; 5、those with a cognitive disorder or immature intelligence, and who cannot control their behavior; 6、those whose expectations for the surgery are not realistic; 7、those unwilling to assume the risks of potential surgical complications; 8、those unable to comply with postoperative dietary and lifestyle changes, showing poor compliance; 9、those in poor general health, who are unable to tolerate general anesthesia or surgery.
chronic-disease self-management program in patients living with long-covid in puerto rico

Conditions: Long Covid19

Summary: this is a pilot non-randomized-controlled trial to evaluate the impact of "tomando control de su salud", an evidenced-based intervention for chronic disease self-management in the quality of life of patients living with long-covid in puerto rico.

patients from our cohort study entitle "the puerto rico covid-19 assessment study" (pr-coas) (irb# 2290030465) will be invited to participate in this pilot study during the 12-month follow-up call. participants with long-covid and at least one chronic diseases that agree to participate in the pilot study will be allocated into one of the study intervention groups that will participate in the "tomando control de su salud" (tcs) workshops. this group will be asked to answer a final interview approximately one month after the last workshop. those not interested in participating in the intervention will receive general information about chronic disease management available at the cdc website in spanish, by email or in person, in addition to their regular health care and will be asked to answer the interview approximately 3 months after the last interview of the pr coas-cohort. investigators expect to enroll approximately 50 participants that will be divide between the groups of intervention and non-intervention. participants will receive an incentive for transportation and/or parking expenses and for the time dedicated for their participation.

Eligibility criteria:
inclusion criteria: 1. adult patients 21 years or older; 2. participant of pr coas-cohort that completed the last interview (12-month-follow-up) and authorized to be contacted for further studies; 3. having at least one chronic condition (excluding cancer) diagnosed by a physician or healthcare provider, and 4. ability to attend weekly sessions. exclusion criteria: 1. any clinical or cognitive impairment that limits the participant's ability to decide to participate in the study or complete the interviews; 2. presence of a life threatening or extreme medical condition, and 3. planning to move out of the municipality within the next year.

Keywords: long covid19 chronic disease self-management evidenced-based program health-related quality of life
effectiveness of ultrasound-aided articulation therapy for children with speech sound disorders

Conditions: ENT System; Cleft Palate Children; Brain Tumor

Summary: the study is a prospective randomized controlled procedure to investigate the effect of ultrasound in articulation training and also the effect of treatment intensity in this mode of therapy. targeted subjects are children with brain tumor or cleft palate with articulation errors which visualization of lingual movement using ultrasound may facilitate their acquisition of the sounds misarticulated. subjects would be randomized to two groups of high and low treatment intensity, with stratification to the groups by disorders, age and gender whenever possible. participants will be randomly assigned to either the treatment group or a waitlist control group in a 1:1 ratio.


Eligibility criteria:
inclusion criteria: * no syndromes or obvious dysmorphic features; no language disorders associated with biomedical conditions (e.g., cerebral palsy, autism spectrum disorder); no oronasal fistula identified in oral examination or diagnosed velopharyngeal insufficiency; hearing thresholds between 0 to 25 db in at least one ear, with no hearing loss exceeding 50 db in the other; cantonese as the first language exclusion criteria: * subjects with syndrome, speech or language disorder associated with biomedical conditions (e.g. cerebral palsy, autism spectrum disorder), hearing threshold higher than 25db in one ear and hearing loss with more than 50db in another ear would be excluded from the study. participants would be excluded fromthe study if they have other planned surgical intervention during the study period.

Keywords: speech and language children treatment ultrasound
randomized double blind placebo controlled clinical trial to evaluate obese and overweight subjects

Conditions: Weight Loss

Summary: the purpose of the study is to evaluate the effect on weight loss in a group of subjects suffering from overweight and mild obesity (bmi between 25 and 32 kg/m2) and with weight \> 75 kg/m2 being administered with a 3 g/day polyglucosamine dosage.

the primary objective of the study is to evaluate the effect on weight loss in a group of subjects suffering from overweight and mild obesity (bmi between 25 and 32 kg/m2) and with weight \> 75 kg/m2 being administered with a 3 g/day polyglucosamine dosage. the secondary objectives of the study are: * to evaluate the effect of supplementation on blood triglyceride levels * to evaluate the effect of supplementation on blood levels of total cholesterol (ct), ldl, and hdl * to evaluate the effect of supplementation on glucose, insulin, insulin resistance assessed by calculating the homeostatic metabolic assessment (homa) * to evaluate the effect of supplementation on liver enzymes (transaminases) and renal function (creatinine) * to evaluate the effect of supplementation on bmi (body mass index) * to evaluate the effect of supplementation on the abdominal circumference * to evaluate the effect of supplementation on body composition evaluated by dual x-ray densitometer (dxa) * to evaluate the effect of supplementation on the serum levels of reactive oxygen species * to evaluate the effect of supplementation on serum antioxidant capacity

Eligibility criteria:
inclusion criteria: * signed written informed consent * age between 18-65 * both sexes - mandatory adequate contraceptive method for women in fertility age * bmi between 25-32 kg/m2 and weigh in \> 75 kg, with no previous diet-therapy attempts with at least a 5% weight loss in the last year * no 3 kg weight fluctuation in the last 3 months * beck depression inventory (bdi) score \< 20 * binge eating scale (bes) score \< 27 exclusion criteria: * shellfish allergy or to any other ingredient in the product * previous diet-therapy attempts with at least a 5% weight loss in the last year * 3 kg weight fluctuation in the last 3 months * presumed or confirmed pregnancy * no contraceptive method for women in fertility age * cardiopathies, nephropathies, hepatopathies, bronchopneumopathies, hemopathies dermopathies clinically significant chronic degenerative cns (central nervous system) diseases * active peptic ulcer, ulcerative colitis, crohn disease, celiac disease, inflammatory bowel disease * alcoholism * epilepsy * past or current malignancies * intellectual disability * significant motor disability * drug abuse * autoimmune diseases * symptomatic cholelithiasis

Keywords: polyglucosamine formoline l112 medical device
effects of musical intervention on patient pain and anxiety for office-based procedures

Conditions: Chronic Pain

Summary: the purpose of this study is to determine if the use of musical intervention reduces patient anxiety and provides a less painful experience during office-based procedures in a pain management clinic setting.

100 patients who are scheduled for interventional procedures will be randomly assigned to either a music intervention group or a no-music group. such interventional procedures include sacroiliac joint (si) steroidal injections, si radiofrequency ablations, peripheral nerve stimulator implantations, caudal and laminar epidural steroidal injections, lumbar medial branch blocks, lumbar medial branch nerve radiofrequency ablations, spinal cord implantation of electro stimulators. these procedures are fluoroscopically guided. each group will consist of 50 participants. participants in the music intervention group will listen to their preferred genre of music during their procedure. the study participants in the music intervention group will listen to music via external speakers played in the procedure room. the music will not be loud enough to disrupt the physician's communication with the patient. the no-music group will receive the same treatment throughout the procedure; however, this group will not listen to music at any time during the procedure. to ensure acute pain and anxiety control, participants in both groups will receive standard analgesic treatment in the beginning of their scheduled interventional procedure. such treatment includes injection and topical application of lidocaine to induce local anesthesia. the patients in both groups will complete a questionnaire that contains vas and stai scoring metrics to measure pain and anxiety levels, respectively. this questionnaire will be completed before and immediately after the procedure. furthermore, we will use salivary cortisol as a non-subjective biomarker of psychological stress in study subjects not undergoing corticosteroid injections. the saliva samples from the study participants will be collected before and after their scheduled office-based procedures. upon collection of saliva samples from the study participants, the samples will be picked up by the labcorp, which then will perform salivary cortisol testing; the results will be reported to the study team.

Eligibility criteria:
inclusion criteria: * scheduled office-based procedure * informed consent is signed by a subject exclusion criteria: * major hearing impairment * sensitivity to music

Keywords: chronic pain pain management
trial comparing tvt secur system and trans vaginal obturator tape for surgical management of stress urinary incontinence

Conditions: Stress Urinary Incontinence

Summary: to compare the efficacy and complications of the tvt secur system (tvt s) and trans-vaginal obturator tape (tvt-o) procedures for the surgical management of female stress urinary incontinence.


Eligibility criteria:
inclusion criteria: * female patients with symptoms of stress urinary incontinence and a positive cough test who require surgical management. cough test is positive when leakage of urine is seen from the urethra synchronously with the patient performing a cough or valsalva manuver with a comfortably full bladder in the lying or standing position. exclusion criteria: * women with predominantly symptoms of urge urinary incontinence * presence of prolapse greater than pelvic organ prolapse quantification (popq) stage 1 or prolapse requiring surgery * detrusor overactivity on cystometrogram at urodynamic testing * previous surgery for incontinence * intrinsic sphincter deficiency (mucp\<20 cm h2o or q -tip \<30o) * voiding dysfunction with postvoid residual \>100 cc