Kornimate/medical-research-clean huggingface dataset:
the letrozole administration during luteal phase

Conditions: Ovarian Hyperstimulation Syndrome

Summary: to investigate the effect of letrozole in patients who have high risk of ovarian hyperstimulation syndrome (ohss) after oocyte retrieval, the incidence of ohss were calculated between letrozole group and supporting treatment group.

1. object: infertility patients who frozen all embryos due to the risk of ohss were randomized allocated to letrozole or polygeline injection group. inclusion criteria meet one of the following conditions: (1) oocyte is more than or equal to 20; (2) human chorionic gonadotropin (hcg) injection on serum estradiol levels greater than or equal to 5000 pmol/l; (3) on the day of oocyte unilateral or bilateral ovarian diameter greater than or equal to 10 cm (4) follicle puncture is larger than or equal to number 20. after the informed consent was signed, letrozole or polygeline injection was randomized allocated after oocyte retrieval. ohss was determined according to golan diagnosis standards. 2. clinical data: including age, infertility duration, body mass index (bmi), basic follicle-stimulating hormone (fsh) and luteinizing hormone (lh), antral follicle number (afc), gn dosage, estradiol level on hcg injection day, the number of oocytes, the number of embryos, early onset ohss incidence, and the existence of ascites. 3. reproductive hormone levels: 1, 4, 7, days after taken letrozole, and the supernatant was collected for serum reproductive hormone test.

Eligibility criteria:
inclusion criteria: 1. oocyte is more than or equal to 20; 2. hcg injection on serum estradiol levels greater than or equal to 5000 pmol/l; 3. on the day of oocyte unilateral or bilateral ovarian diameter greater than or equal to 10 cm; 4. follicle puncture is larger than or equal to number 20. exclusion criteria: allergic to the letrozole or polygeline.

Keywords: letrozole ohss
ct radiomic features of pancreatic neuroendocrine neoplasms

Conditions: Pancreatic Neuroendocrine Tumor

Summary: the aim of this study is to quantify inter-observer variability in delineating pancreatic neuroendocrine neoplasm (pannen) on computerized tomography (ct) images and its impact on radiomic features (rf), subsequently to this determination, to use ct texture analysis to predict, histological characteristics of pannen on ct scans.

ct imaging is the most widely used modality for studying radiomic features due to its ability to assess tissue density, shape, texture and size before, during and after therapy. to the best of the investigator's knowledge, the impact of inter-observer delineation variability on the reliability of ct rf for pannen patients, including hounsfield unit (hu) values-, shape-, and texture-based features, has not yet been assessed. one this has been determined, an additional evaluation will be conducted to correlate the morphologically observed images with their histopathological characteristics. the ultimate potential objective of this research is to identify and predict characteristics of aggressiveness of pannen in ct scans.

Eligibility criteria:
inclusion criteria: * \> 18 years of age * pancreatic neuroendocrine neoplasm with intervention and biopsy * availability of pre-operatory ct scan with or without iv contrast agent- ininstitution from 2009-2017 exclusion criteria: * pregnant women

Keywords: radiomics pancretic neuroendocrine neoplasms (pannen)
network connectivity and temporal processing in adolescents who stutter

Conditions: Stuttering, Childhood; Stuttering

Summary: the specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter. the overall project also aims to investigate how performance on rhythm tasks may be related to brain activity (non-clinical trial).

participants in the clinical trial portion of this study will complete rhythm discrimination and finger tapping experiments once a year for 3 years. the study team will compare performance between groups. participants will also participate in the non-trial portion of the project that includes having magnetic resonance imaging (mri) each year for 3 years.

Eligibility criteria:
inclusion criteria children who stutter: * english as primary language * current or past stuttering diagnosis inclusion criteria children who do not stutter: * english as primary language exclusion criteria children who stutter: * diagnosed/under treatment for any neurological or psychiatric conditions * head trauma with loss of consciousness * major medical illness * hearing loss- language/motor delay (below -2 standard deviations on standardized assessments) * face, motor, or reflex abnormalities exclusion criteria children who do not stutter: * personal or family history of stuttering * diagnosed/under treatment for any neurological or psychiatric conditions * head trauma with loss of consciousness * major medical illness * hearing loss * language/motor delay (below -2 standard deviations on standardized assessments * face, motor, or reflex abnormalities

Keywords: rhythm temporal processing healthy children speech disorders timing
sonographic evaluation of patients with carpal tunnel syndrome following steroid injection

Conditions: Carpal Tunnel Syndrome

Summary: the objective of this study was to assess sonographic changes of the median nerve after steroid injection for carpal tunnel syndrome.

patients with cts were recruited. the boston questionnaire (bq) was administered and ultrasonographic and electrophysiological examinations were performed before and at two, six, and 12 weeks after steroid injection. cross sectional area (csa) was measured at 2 levels: at the tunnel inlet and in the mid-carpal tunnel. flattening ratio (fr) was measured only in the mid-carpal tunnel. correlation analyses between baseline ultrasonography, bq, and electrophysiological measures were performed.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of cts 2. the diagnosis of cts was confirmed by electrophysiological tests. exclusion criteria: 1. neurologic disorders that could mimic cts such as cervical radiculopathy, polyneuropathy, proximal median nerve entrapment, or thoracic outlet syndrome 2. history of distal radius fracture 3. pregnancy or lactation 4. regular use of systemic nsaids or corticosteroids 5. known allergy to corticosteroids and local anesthetics.

Keywords: carpal tunnel syndrome
effect of low fermentable oligosaccharides, disaccharides ,monosaccharides and polyols (fodmap) diet on control of pediatric irritable bowel syndrome and quality of life

Conditions: Irritable Bowel Syndrome

Summary: to evaluate the impact of low fodmap diet on health related quality of life in children with irritable bowel syndrome according to rome iv criteria in a group of patients in pediatric hospital at ain shams university

single blinded randomized two-arm intervention study in which 42 patients with irritable bowel syndrome were enrolled to study the effect of low fodmap diet ( intervention group) on their gastrointestinal symptoms and their quality of life another group of 42 patients of ibs were enrolled as a control group who were received general diet instructions and they followed the nice guide lines for ibs management

Eligibility criteria:
inclusion criteria: * children aged 5-15 years old fulfilling rome iv criteria of ibs diagnosis exclusion criteria: patients presenting with : * abdominal pain or diarrhea that wakes the child from sleep * delay in onset or progression of puberty. * faltering growth. * family history of inflammatory bowel disease, celiac disease. * history of significant weight loss . * bleeding per rectum. * persistence of severe vomiting or diarrhea * . persistent joint pain. * recurrent unexplained fever. * unexplained pallor
perspectives and management of atypical asthma

Conditions: Asthma

Summary: to evaluate the awareness/knowledge, clinical practice of atypical asthma among respiratory specialists and primary care practitioners (pcps) in china.a total of 1166 respiratory specialists and 799 pcps participated in the questionnaire survey via wechat. the questionnaire included six major items, divided into physician demographic characteristics, awareness, diagnosis, medication prescription, assessment/education, and proposal.


Eligibility criteria:
inclusion criteria: * grade hospital respiratory doctor，pediatrician，and doctors in primary hospitals exclusion criteria: * none
optimal adult heart transplant immunosuppression with microrna levels (optimal)

Conditions: Cardiac Failure; Graft Rejection

Summary: this study aims to develop and refine a mir biomarker panel that can be used to phenotype net immune state after heart transplantation.

the study objectives will be accomplished in a prospective, longitudinal, multicenter, multiracial, multiethnic cohort study that includes adult heart transplant patients from geographically and socioeconomically diverse regions of the u.s. patients will be screened for eligibility and enrolled \~1 month (± 2 weeks) after transplant. all patients will follow the center's standard of care surveillance schedule after transplant. blood samples will be collected for mir evaluation at 1. specified time intervals after transplant 2. when a clinical event of interest occurs, including rejection or infection. research samples will be collected and used to evaluate microrna expression as well as other biomarkers related to heart transplantation and immunosuppressive medications. additional data collection will include demographics, medical history, medications, human leukocyte (hla)/donor specific antibody (dsa) evaluations, endomyocardial biopsy (emb), echocardiography, donor-derived cell-free dna (dd-cfdna), and other post-transplant events and testing.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years at enrollment * receipt of orthotopic heart transplant (oht) within the prior 1 month ± 2 weeks * planned follow-up at the transplant center for a minimum of one-year. * patient able and willing to comply with the study visit schedule, study procedures, and study requirements. exclusion criteria: * recipient of a multi-organ transplant * history of prior solid organ transplant before the index heart transplant * ongoing mechanical circulatory support or hemodynamic instability (e.g., inotrope or vasopressor therapy) * ongoing need for renal replacement therapy and/or dialysis * active infection requiring either a) hospitalization b) treatment with antimicrobial therapy or c) reduction in immunosuppression * active rejection being treated with intravenous medications or plasmapheresis
single shot intrathecal analgesia in vaginal delivery

Conditions: Effectiveness of Single Shot Intra-thecal Analgesia in Multiparous Women Scheduled for Normal Vaginal Delivery

Summary: effectiveness of single shot intra-thecal analgesia in multiparous women scheduled for normal vaginal delivery

labor is a physiological and natural process, as well as a complicated and subjective experience.except for a few women, childbirth is unquestionably a painful experience. women's understanding of delivery's pain is influenced by various factors, making each experience special. as opposed to other painful life events, labor pain consistently ranks high on the pain rating scale. in this study ,the investigators are going to investigate the effectiveness and safety of intrathecal analgesia for labour using bupivacaine with fentanyl or dexmedetomidine.

Eligibility criteria:
* inclusion criteria: * multiparous women who received antenatal care, presented for vaginal delivery of uncomplicated term pregnancy of singleton fetus with engaged fetal head and cervical dilatation of at least 5 cm requiring oxytocin augmentation, and requested analgesia. * age: patients between 22-45 years old. * exclusion criteria: * refusal of procedure or participation in the study. * patients with pre-existing or pregnancy-induced hypertension, abnormal fetal heart rate tracings, obesity, endocrinal diseases and/or diagnosed fetal abnormalities. * contraindication to neuraxial block. * allergy to any of the study drugs.
a randomized study comparing lamivudine versus adefovir dipivoxil for prevention of zhbv reactivation in hbsag seropositive patients undergoing cytotoxic chemotherapy

Conditions: Hepatitis B

Summary: liver diseases due to hepatitis b reactivation are serious causes of morbidity and mortality in hepatitis b infected patients treated with chemotherapy. we have previously shown that with pre-emptive use of lamivudine, one can drastically reduce liver-related morbidity and mortality in such patients. however, due to the development of hepatitis b virus resistance to lamivudine, some of these hepatitis b infected patients still develop hepatitis. this is a research study aiming to compare the use of adefovir dipivoxil to lamivudine in hepatitis b infected patients treated with chemotherapy. both of these drugs have been approved for the treatment of the hepatitis b infection in the united states, european union and hong kong. all patients who were recruited in this study will receive study medication, either lamivudine 100 mg daily or adefovir dipivoxil 10 mg daily to cover the entire period of chemotherapy for 72 weeks. all patients will be follow-up for an additional 24 weeks thereafter. altogether, 70 subjects will be recruited from queen mary hospital, hong kong sar. this is an open-label study, which means that the patients and the study doctor will know which treatment the subjects are assigned into. if a subject decides to take part in the study and is found eligible, he/she will be randomly (like flipping of coin) assigned to one of the following dose groups: lamivudine (100 mg) tablet adefovir dipivoxil (10 mg) tablet


Eligibility criteria:
inclusion criteria: * hbsag+, nucleoside/nucleotide analogue naïve, malignant disease for iv chemotherapy exclusion criteria: * hcv+ hdv+

Keywords: hbv
anesthetic and obstetric outcomes in morbidly obese pregnancy and cesarean delivery

Conditions: Morbid Obesity; Cesarean Section Complications; Pregnancy Related

Summary: given that morbid obesity has been strongly associated with obstetric, neonatal and anesthetic complications, and that scarce reports have evaluated anesthetic and obstetric outcomes after cesarean delivery in morbidly obese patients; this study retrospectively analyzed anesthetic, obstetric and neonatal outcomes in morbidly obese pregnant patients who underwent cesarean delivery at augusta university medical center, during a 2-year period (2015-2016).

this study compared non-obese, obese and morbidly obese patients with respect to maternal, perinatal and anesthetic outcomes. obstetric aspects included emergent procedure, estimated blood loss, obstetric complications, maternal disposition, length of stay and in-hospital mortality. neonatal aspects included apgar scores. anesthetic aspects included anesthetic technique, intraoperative hemodynamic instability, failed regional anesthesia and anesthetic complications.

Eligibility criteria:
inclusion criteria: * pregnant patients who underwent cesarean section at augusta university medical center. * patients older than 18 years. exclusion criteria: * gestational age \<37 weeks. * patients with chronic pain conditions
the effect of oral carbohydrate inhalation given to patients before coronary artery bypass graft operation on recovery

Conditions: Surgery

Summary: the aim of this study was to investigate the effect of oral carbohydrate solution given to patients before coronary artery bypass graft surgery on nausea-vomiting, hunger, thirst, physiologic parameters and recovery. the study will be completed with a total of 120 participants, 40 control, 40 placebo and 40 experimental. as a randomization method, simple randomization method will be used to provide an equal number of samples in three groups and patients will be informed verbally about the study and written informed consent will be obtained from patients who agree. in this study, the effects of oral carbohydrate solution administration on nausea and vomiting, hunger, thirst, physiologic parameters and recovery were evaluated before coronary artery bypass graft surgery.

experimental: oral administration of carbohydrate solution patients will receive 800 ml of oral carbohydrate solution until midnight before surgery and 400 ml until 2 hours before surgery. patients will be administered a patient information form before surgery. postoperative recovery index (turkish version), visual comparison scale, physiologic parameters and blood glucose monitoring form and number and dosage of antiemetic drugs taken in 24 hours postoperatively will be applied. placebo: administration of flavored water patients will be given 800 ml of flavored water until midnight before surgery and 400 ml of flavored water until 2 hours before surgery. patients will be given a patient information form before surgery. postoperative recovery index (turkish version), visual comparison scale, physiologic parameters and blood glucose monitoring form and number and dosage of antiemetic drugs taken in 24 hours postoperatively will be applied. control: no intervention patients will be administered a patient information form before surgery. postoperative recovery index (turkish version), visual comparison scale, physiologic parameters and blood glucose monitoring form and number and dosage of antiemetic drugs taken in 24 hours postoperatively will be applied.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * planned coronary artery bypass graft surgery * volunteering to participate in the research exclusion criteria: * under 18 years of age * not planned coronary artery bypass graft surgery * not volunteering to participate in the research * cases received as an emergency

Keywords: surgery eras nursing cardiovascular
effect of intraoperative dexmedetomidine on early postoperative cognitive dysfunction

Conditions: Cognitive Dysfunction

Summary: this study will aim to identify the impact of intraoperative dexmedetomidine infusion on pocd assessed by the montreal cognitive assessment (moca) in geriatric patients above 60 years undergoing hip surgery under spinal anaesthesia.

postoperative cognitive dysfunction (pocd) is a common postoperative neurological complication in elderly. pocd is a subtle impairment of memory, concentration and information processing with clinical manifestations of delirium, anxiety, personality changes and impaired memory, which is associated with prolonged hospitalization, a reduced quality of life and an increase in morbidity and mortality. dexmedetomidine is a highly selective α-2 adrenergic receptor agonist with a dose-dependent sedative hypnotic effect. it has also been reported that dexmedetomidine has a potential role in preventing pocd due to its neuroprotective effects both in vitro and in vivo. till date very few studies have analysed the impact of dexmedetomidine on early pocd. even in the few available studies compared assessment of pocd using the mini-mental state examination (mmse) scores and found that mmse have lower sensitivity for identifying cognitive dysfunction as compared to montreal cognitive assessment (moca). the study would analyze the impact of intraoperative dexmedetomidine infusion on early postoperative cognitive dysfunction (pocd) in geriatric patients above 60 years undergoing hip surgery under spinal anesthesia. so this study will aim to identify the impact of intraoperative dexmedetomidine infusion on pocd assessed by the montreal cognitive assessment (moca) in geriatric patients above 60 years undergoing hip surgery under spinal anaesthesia.

Eligibility criteria:
inclusion criteria: * american society of anesthesiology (asa) status of i-iii * age between 60-75 years scheduled for elective hip surgery under spinal anesthesia exclusion criteria: * patient not willing to be a part of the study * patients were aged \ 75 years * patients with accompanying medical conditions that may affect the level of consciousness, such as stroke, stupor or dementia, or patients with abnormalities in hepatic or renal function, electrolyte imbalance * patients suffering from preoperative bradycardia \[heart rate (hr) \<60 bpm\] or hypotension \[mean arterial blood pressure (map) \<70 mmhg\] * patients who had recently received a sedative or opioid drug * patients with a moca (montreal cognitive assessment) score \<26 * patients with persistent hypotension and bradycardia intra-operatively even after giving mephentermine will be excluded from the study
combining vns with pt interventions for individuals with pd

Conditions: Parkinson Disease

Summary: the purpose of this study is to evaluate the combined effects of non-invasive neuromodulation (specifically transauricular vagus nerve stimulation) with exercise interventions to improve physical function and quality of life in individuals with parkinson\&#39;s disease.

during this clinical trial, participants will be randomized into two groups, with half of the participants assigned to group 1: active tavns + exercise, and half of the participants assigned to group 2: sham tavns + exercise. the active tavns + exercise group will receive 15 minutes of active tavns prior to treatment. participants who are randomized into the sham tavns + exercise group will receive 0 ma of current for 15 minutes prior to treatment. all participants will be guided through exercises by a licensed physical therapist, which will include: 1) intensive exercises that focus on increasing the size and amplitude of movements; 2) task-specific practice, which involves practicing functional tasks, such as dressing, bathing, and cooking, in order to transfer the gains made in therapy to real-life situations. the exercise intervention proposed involves the supervision of a licensed pt at all times during the treatment session. exercise will be provided in a clinical setting, 45 minutes per session, up to 3 sessions/week, for 4-6 weeks total.

Eligibility criteria:
inclusion criteria: * diagnosis of pd by a board-certified neurologist * age between 35 and 80 years * no walking aids * stable medication 4 weeks prior to and during the study * no falls in the past 6 months * participant must have md who is willing to provide oversight and approval for clinically defined \&#34;off\&#34; state exclusion criteria: * mild cognitive impairment (moca \&lt;25) * self reported depression * antidepressive or antipsychotic medication * participation in a vns study in the past year * disabling bradykinesia to ensure patients are able to participate in intensive physiotherapy (based on clinical impression and in accordance to updrs part iii item 14 - to be administered in clinic) * prior history of cardiovascular, neurological or musculoskeletal disorders known to interfere with testing pd features * implanted medical device of any type * history of seizures * peripheral neuropathy including temporal mandibular disorders and bells palsy, and * vasovagal syncope.

Keywords: parkinson's disease exercise vagus nerve stimulation vns tavns