Kornimate/medical-research-clean huggingface dataset:
stretching techniques of knee muscles and their effect on joint range, suppleness and muscle activity in elderly

Conditions: Muscle Tightness; Muscle Weakness

Summary: the goal of this clinical trial was to compare the effect of two different types of stretching techniques in elderly population. the main questions it aims to answer are: 1. what is the immediate effect (after a single intervention) of these stretching techniques on muscle flexibility, amount of knee joint motion and muscle activity? 2. what is the effect of a four week intervention program of these stretching techniques on muscle flexibility, amount of knee joint motion and muscle activity? there were three groups with ten randomly allocated participants in each group. intervention group i was given a stretching technique called contract-relax technique and the intervention group ii was given static stretching. the third group was not given any treatment and was taken as a control. the main aim was to find out that whether the two techniques are effective or not and which one of the two is better than the other in terms of improvement in the above mentioned parameters.

the objective of the study was to compare the effects of proprioceptive neuromuscular facilitation - contract relax (pnf- cr) and static stretch techniques immediately and post four weeks of intervention on knee range of motion, flexibility and electromyographic activity of knee muscles among older adults. this is an outcome assessor-blinded pre-test post-test randomized controlled trial with two experimental groups (pnf-cr and static stretching) and a control group. 30 males aged 55-75 years were randomly assigned into pnf group (n=10), static stretch group (n=10) and control group (n=10). knee range of motion, electromyographic activity of hamstrings and sit and reach test, were taken for the dominant side thrice: pre-intervention, immediately after stretching and after the training period. active knee range of motion (rom) was assessed using a universal goniometer. surface electromyography (emg) was used to record maximal voluntary isometric contraction (mvic) of biceps femoris and the chair sit-and-reach test (cart) was used to assess the hamstring muscle's length flexibility.

Eligibility criteria:
inclusion criteria: * male adults aged between 55 and 75 years * able to do activities of daily living (adl) without assistance * able to comprehend and follow instructions exclusion criteria: * grade iii or iv osteoarthritis or any other musculoskeletal condition affecting the muscle length. * history of any surgery to hip, knee, low back or ankle * history of any medication (anti-inflammatory, for pain relief, or anti-arthritic) in previous six months * history of life-threatening disease (neurological disease, cardiovascular disease, severe hypertension) * passive full knee extension (popliteal angle 180 degrees)

Keywords: contract relax proprioceptive neuromuscular facilitation electromyography elderly flexibility range of motion
comparison of effects of oxycodone and sufentanil on cardiovascular stress induced by tracheal intubation in the patients with coronary heart disease undergoing major noncardiac surgery

Conditions: Cardiovascular

Summary: to evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (chd).

laryngoscopy and tracheal intubation can provoke an increase of blood pressure (bp) and/or hr \[1.2\]. this hemodynamic stress may lead to an imbalance between myocardial oxygen consumption and supply and therefore induce myocardial ischemia, which may be endurable in the patients with normal cardiovascular condition but is potential harmful to the patients with coronary heart disease. thus it is critical to attenuate the cardiovascular stress induced by laryngoscopy and endotracheal intubation in the high risk patients.

Eligibility criteria:
inclusion criteria: the coronary angiography from each patient showed that lesions exist in at least one main coronary artery exclusion criteria: a history of reactive airway disease, gastroesophageal reflux, morbid obesity, a known or predicted difficult airway

Keywords: oxycodone sufentanil tracheal intubation
evaluating a group-based therapeutic yoga program for burnout

Conditions: Anxiety; Insomnia; Burnout, Professional; Depression; Loneliness

Summary: this study is evaluating a group-based therapeutic yoga program for burnout. this study aims to understand the feasibility of running the program (i.e. of recruiting participants, the resources required to run the program, etc) and the effectiveness of the program (i.e. in decreasing participants' mental health symptoms).

a primary care group-based therapeutic yoga program, the yoga md program, was developed by a primary care / emergency physician practicing in toronto, ontario. the program was started in 2014 and is run through a medical centre in toronto, ontario. the purposes of the program are to understand: * key concepts of yoga, mindfulness, compassion, acceptance and how these can help with personal transformation * how stress is carried in the body (embodiment of stress) and how stress manifests as anxiety, pain, or other symptoms * what happens when stress accumulates in the body * the role of self-compassion in the response to stress * how to cope with difficult emotions that may contribute to stress * how to deal with difficult people and trying relationships * the importance of connecting with, and caring for ourselves to reduce accumulated stress * how to solidify healthier patterns to build resilience to stress faced in daily life. this study evaluates the 9 weekly sessions using a before-after interventional design. participants have data collected at baseline, and at 9 weeks and 8 months after the yoga program ends, and changes in mental health outcomes are observed.

Eligibility criteria:
inclusion criteria: * age of 18 * must be enrolled in therapeutic yoga program exclusion criteria: * no formal exclusion criteria

Keywords: anxiety yoga mindfulness group-based therapy
prevention of recurrent preterm delivery by a natural progesterone agent

Conditions: Pregnancy; Premature Birth

Summary: to examine the preterm delivery rate of a preterm delivery high risk group of pregnant women, using once daily natural progesterone agent.


Eligibility criteria:
inclusion criteria: pregnancy 24 weeks' gestation preterm labor in previous pregnancies - exclusion criteria: * no medications for ptl or any kind of progesterone. * cervical suture * multiple pregnancy

Keywords: pre-term labor progesterone
increasing knowledge of alcohol as a risk factor for breast cancer among women attending breast screening services

Conditions: Health Knowledge, Attitudes, Practice; Alcohol Consumption

Summary: alcohol is a major modifiable risk factor for breast cancer in women, yet this is not widely understood by health practitioners or policy makers, let alone the general population. the investigators aim to test the effects of a targeted alcohol and lifestyle brief intervention for women attending breast screening services, to improve knowledge of alcohol as a risk factor for breast cancer and reduce harmful alcohol use.


Eligibility criteria:
inclusion criteria: * female * attending breast screening service for a routine mammography * 40-74 years * english as a first language or fluent * regular access to a telephone * able to provide informed consent to participate * any level of alcohol consumption (including non-drinkers) exclusion criteria: * hearing impairment sufficient to prohibit a telephone interview * pregnancy * not able to read or comprehend english to provide informed consent or receive the brief intervention

Keywords: women's health public health health promotion/education
clinical trial for 'shen qu xiao shi' oral liquid in the treatments of children's functional dyspepsia

Conditions: Dyspepsia

Summary: with domperidone suspension as the control, the effect of shenqu xiaoshi oral liquid on functional dyspepsia in children was evaluated objectively through multi-center, randomized, double-blind and double-simulation experiment, which alleviated the clinical symptoms, restored and promoted the normal growth and development of children.


Eligibility criteria:
inclusion criteria: 1. children aged 3-14 years, regardless of gender; 2. meet 1 or more conditions: (1) full after dinner; (2) early full; (3) abdominal pain, and defecation has nothing to do; after appropriate evaluation, symptoms cannot be fully explained by other diseases; or have other symptoms of dyspepsia, but not caused by other diseases; 3. have symptoms at least 2 months before diagnosis and at least 4 days per month; 4. during the 2-week leading-in period, no drugs were used to treat infantile anorexia and functional dyspepsia, and good eating habits were established. the patients were fed on time and still had the above-mentioned symptoms of anorexia and functional dyspepsia; the symptom score was 3. 5. the legal guardian of the child should sign the informed consent form. if the child is 10 years old or older, they should sign the informed consent form and agree to participate in the study. exclusion criteria: 1. anorexia and dyspepsia caused by anorexia or dyspepsia caused by the influence of certain drugs or other confirmed diseases, such as erosive gastritis and gastric ulcer; 2. children with severe malnutrition; 3. children with abnormal ecg, liver and kidney functions, nervous system, respiratory system and endocrine system considered by the investigator; 4. children with mental disorders, dementia and unclear speech; 5. lactose intolerance or allergy to drug ingredients, or allergy to traditional chinese medicine; 6. children who have participated in other clinical trials or are participating in clinical trials of other drugs within 12 weeks; according to the judgment of the researchers, there are other diseases or conditions that reduce the possibility of enrollment or complicate enrollment, such as unstable living environment and inconvenient transportation, which are easy to cause loss and follow-up.

Keywords: functional dyspepsia children traditional chinese medicine
the effect of thoracic epidural anesthesia with different block level on propofol induction

Conditions: Target Controlled Infusion (TCI); Thoracic Epidural Anesthesia; Block Level; Gastrointestinal Surgery

Summary: it is a prospective, randomized, placebo-controlled study to investigate the effect of tea with different block level on propofol concentration during general anesthesia induction.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) i-ii physical status, * aged 40-60 yr, * bmi 19-25 kg/m2, * undergoing elective gastrointestinal surgery exclusion criteria: * patients with cardiovascular or neurological disease, drug or alcohol abuse and absolute contraindications for neuraxial blockade.

Keywords: effect-site concentration propofol thoracic epidural anesthesia
vaginal microbiota among postmenopausal women

Conditions: Vulvovaginal Atrophy

Summary: it is known that vaginal bacteria have an impact upon the health status of the host, in some cases protecting against infection and in other cases causing infection, depending on the bacterial types present. this study will compare the composition of vaginal bacteria to symptoms of vaginal dryness in order to try and identify if certain bacteria might cause some of the problems associated with vaginal dryness among post-menopausal women.


Eligibility criteria:
inclusion criteria: * between 30 and 80 years old. * postmenopausal = 12 months of spontaneous amenorrhea or 6 months of spontaneous amenorrhea with serum fsh levels \> 40 miu/ml or 6 weeks postsurgical bilateral oophorectomy with or without hysterectomy. * prepared not to take hormone replacement therapy during 8 weeks follow-up and not taking estrogen alone or estrogen/progestin containing drug products at the time of screening.
live stream of ultrasound in prehospital medical care

Conditions: Ultrasound

Summary: prehospital emergency ultrasound (peu) is being increasingly used in different preclinical emergency systems across the world. ultrasound examinations in emergency situations, however, remain challenging even in the hospital setting despite the availability of standardized approaches such as focused assessment with sonography for trauma (fast). preclinical circumstances further complicate the adequate execution of an additional diagnostic tool such as peu on the scene or inside a medical emergency vehicle. furthermore, rapid translation of ultrasound findings into meaningful therapeutic consequences is considerably demanding in an environment of limited resources. if focused peu is correctly used and patients' condition allows emergency doctors a careful ultrasound examination, it is possible to differentiate life-threatening diagnoses. peu should be implemented in the management of emergency patients affected by trauma, cardiac arrest/shock or respiratory problems. to date it is unclear whether peu results in improved outcome. some emergency cases present difficult challenges in the prehospital ultrasound examination. portable devices designed for peu suggest the possibility of increasing the use of ultrasound "in the field". however, to the investigator's knowledge, opportunities for real-time consultation with a second specialist including live transmission of the ultrasound picture are not being provided at any preclinical emergency facility.

aim 1: feasibility of real time prehospital emergency ultrasound (peu) transmission in a university affiliated preclinical emergency system. aim 2: identify obstacles for peu transmission including a real time consultation of an ultrasound expert. hypothesis: we expect that live streaming of emergency ultrasound images in order to allow a second opinion could improve diagnostics of life threatening conditions and help us to improve patients' safety by digital health. the use of peu is feasible and safe.

Eligibility criteria:
inclusion criteria: emergency patients affected by: * trauma * cardiac arrest/shock * respiratory problems exclusion criteria: * patients rejection. * legal representative's rejection.

Keywords: echocardiography emergency medicine telemedicine
improving clinical efficiency by reducing scheduled follow-ups using cochlear america's population mean mapping strategy

Conditions: Deafness; Cochlear Hearing Loss

Summary: the study is about the importance of each follow-up visit after activating a new cochlear implant in addition to evaluating the effectiveness and efficiency of a new programming strategy from cochlear americas. investigators are looking for patients who have recently selected cochlear americas as their cochlear implant manufacturer of choice for their upcoming surgery. the aim of this study is to determine if 1) patient outcomes remain stable when reducing follow-up appointments and 2) cochlear's population mean mapping can produce similar outcomes with patients while additionally reducing appointment times. the hypothesis is that using population mean mapping and reducing the number of follow-up visits after activation will yield similar performance outcomes to a standard of care while decreasing the length of appointment times and number of appointments needed for each patient.


Eligibility criteria:
inclusion criteria: * postlingually deafened * adults (18+) * new cochlear implant recipients with cochlear americas devices; identified prior to activation * able to perform follow-up testing tasks (repeating words/sentences, indicating they heard a sound stimulus, completing questionnaires) * english speakers exclusion criteria: * patients who select other cochlear implant manufactured devices * pre-lingually deafened * multiple disabilities * unable to perform follow-up testing tasks (repeating words/sentences, indicating they heard a sound stimulus, completing questionnaires) * non-english speakers * children under the age of 18
bioday registry: data collection regarding the use of new systemic treatment options in patients with atopic dermatitis

Conditions: Atopic Dermatitis

Summary: the bioday registry aims to address the need for daily practice data regarding the effectiveness and safety of new systemic treatment options (like biologics and janus kinase inhibitors) in patients with atopic dermatitis and effect on other atopic comorbidities in a multicenter setting. the registry already consists of several additional modules concerning atopic comorbidities, like food allergy and asthma, and a module for conjunctivitis during biologic treatment.


Eligibility criteria:
inclusion criteria: * all adult and paediatric patients treated with new systemic treatments for ad will be asked for participation in the bioday registry exclusion criteria: * patients are not eligible for enrolment in case of presumed inability to answer questionnaires or not willing to answer questionnaires and will be excluded.

Keywords: atopic dermatitis dupilumab dupixent bioday daily practice real world atopic diseases registry registry multi center biologics janus kinase inhibitors baricitinib upadacitinib abrocitinib tralokinumab
protocol of self-regulation in early learners: the role of recreational programs

Conditions: Self Regulation; Impulsive; Attention Difficulties; Emotion Regulation

Summary: protocol of self regulation in early learners: the role of recreational activity program (rap) rap, which included fun games and lasted 24 sessions, was applied to the students in the study group. twenty-four sessions include games that help gain rhythm, balance, and patience. the program is planned according to the game theory model, which aims to have fun for children. the program, which aims to develop children's self-regulation skills based on the essential reflections of the model, will include fun games with simple rules. before the program was implemented, the researchers informed the experimental group about the research and the program, and verbal consent was obtained from the participants.

the study titled "protocol of self-regulation in early learners: the role of recreational programs" focuses on the influence of structured recreational activities on the development of self-regulation skills among preschool children. self-regulation is a crucial ability, facilitating children's academic performance, social behaviors, and emotional well-being. rap, which included fun games and lasted 24 sessions, was applied to the students in the study group. twenty-four sessions include games that help gain rhythm, balance, and patience. the program is planned according to the game theory model, which aims to have fun for children. the program, which aims to develop children's self-regulation skills based on the essential reflections of the model, will include fun games with simple rules. before the program was implemented, the researchers informed the experimental group about the research and the program, and verbal consent was obtained from the participants.

Eligibility criteria:
inclusion criteria: attending at least 22 sessions - exclusion criteria: -

Keywords: self regulation recreational activities preschoolers
effect of inhalation of low dose co2 on exercise performance at high altitude

Conditions: High Altitude; Inhalation; Gas; Acute Mountain Sickness

Summary: high altitude (\>2400 m) is associated with decreased atmosphere pressure leading to hypoxia which in turn impairs exercise capacity and causes acute mountain sickness (ams). it is noted that adding co2 might be beneficial to improve hypoxia and exercise performance at high altitude. however, no device is currently available that can supply a constant low dose of co2 during free movement at high altitude. we have recently invented a portable device which is small and light enough for supplement of low dose co2 during field exercise at high altitude.

objective: to determine whether the supplement of low-dose co2 by the novel device could improve exercise performance at high altitude. methods: the lowlanders (\ 1000m) a year before the study will be recruited. and the subjects who are high-altitude residents and have not left high altitude over the last twelve months will also be recruited for the study. subjects will be randomly and blindly given either co2 mixed with air or air alone during endurance shuttle walking test (eswt). blood gases will be measured before and after inhalation of co2. eswt time, ventilation per minute (ve), blood oxygen saturation (spo2), and end-tidal co2 concentration (etco2) will be measured during exercise and will be compared during inhalation of co2 and during inhalation of ambient air.

Eligibility criteria:
inclusion criteria: 1. healthy lowlanders (\ 1000m) a year before the study. 2. healthy high altitude (4500m) residents who have not left the inhabited area over the last twelve months before the study. exclusion criteria: 1. subjects with cardiovascular diseases, respiratory diseases and neuromuscular diseases which could affect exercise.

Keywords: high altitude exercise performance co2 inhalation
assessment of spinal posture, balance and ankle muscle shortness i̇n children with autism

Conditions: Autism

Summary: the aim of this study is to evaluate spinal posture, mobility, balance and ankle muscle shortness in children with autism. the study will feature two groups, * first group will consist of children with autism * second group will consist of typically developing children childhood autism assessment scale will be completed with the families of the children included in the study. the tiptoe walking status of the children participating in the study will be observed and classified according to the tiptoe walking classification. children's balance skills will be evaluated with pediatric berg balance test and timed get up and walk test, ankle muscle shortness will be evaluated with gastro-soleus shortness measurements, spinal posture and mobility will be evaluated with spinal mouse. the evaluation results of both groups will be compared. the main questions this study aims to answer are: * spinal mobility is decreased in children with autism compared to typically developing children. * thoracic kyphosis is greater in children with autism compared to typically developing children. * balance skills are poorer in children with autism compared to typically developing children. * the severity of tiptoe walking increases as gastro-soleus muscle shortness increases.


Eligibility criteria:
inclusion criteria: * being diagnosed with autism spectrum disorder in the special needs report for children (çözger) * gmfcs level i or ii * between the ages of 6-18 * iq score of 50 or more as determined in the special needs report for children (çözger) * volunteering to participate in the study exclusion criteria: * having a rigid contracture of the columna vertebralis * having undergone scoliosis surgery * having a rigid contracture in passive knee extension and ankle range of motion * history of surgery or botox affecting ankle joint range of motion in the last 6 months