Kornimate/medical-research-clean huggingface dataset:
an interocular comparative study of unilateral cataract

Conditions: Cataract

Summary: the purpose of this cross-sectional study is to compare bilateral anterior segment parameters, macular thickness, and bcva at 3 months after uncomplicated unilateral pediatric cataract extraction with primary iol implantation to explore any possible interocular differences and their possible relationships.

great advances have been made in managing pediatric cataracts during the last several decades; these advances have contributed to a decrease in the incidence of postoperative complications and improvement in visual outcomes.early cataract removal and replacement with an intraocular lens (iol) represent the most appropriate treatments to avoid irreversible amblyopia.although screening and timely surgical intervention play a key role in improved best corrected visual acuity (bcva) among pediatric patients with cataracts, determining the prognosis for an individual remains difficult, particularly for unilateral cataract. few studies have focused on the interocular differences in ocular anatomic parameters other than axial length in unilateral pediatric cataract after surgery, the significance of which for the possible interocular visual functional difference remains unclear. therefore, the investigators conducted this cross-sectional study to compare bilateral anterior segment parameters, macular thickness, and bcva at 3 months after uncomplicated unilateral pediatric cataract extraction with primary iol implantation to explore any possible interocular differences and their possible relationships.

Eligibility criteria:
inclusion criteria: * children with uncomplicated surgeries * children who were younger than 10 years old * children with unilateral total cataract exclusion criteria: * premature birth * microphthalmia * micro-or megalocornea * keratoconus * glaucoma * traumatic or complicated cataracts * vitreous and retinal diseases * any previous surgeries
the effects of behavioral activation and physical exercise on depression

Conditions: Depression

Summary: the purpose of this study is to compare an internet-based behavioral activation program with a physical activation program, as treatments for mild to moderate depression. the added effect of rationale and motivational interviewing will also be studied, as well as the effects of relapse prevention program.

background: despite their potential as low-threshold, low-cost and high-flexibility treatments of depression, behavioural activation and physical exercise have not yet been directly compared. this study will examine the effects of these interventions, administered via the internet. the added effect of providing a treatment rationale will also be studied, as well as a relapse prevention program featuring cognitive behavioural therapy components. methods/design: this randomised controlled trial will include 500 participants meeting the diagnostic criteria for major depression, recruited in multiple cycles and randomised to either a waiting list control group with delayed treatment, or one of the four treatment groups: (1) physical exercise without a clear treatment rationale; (2) physical exercise with treatment rationale; (3) behavioural activation with treatment rationale; or (4) behavioural activation without a clear treatment rationale. post treatment, half of the participants will be offered a relapse prevention program. primary outcome measure will be the patient health questionnaire 9-item. secondary measures include diagnostic criteria for depression, as well as self-reported anxiety, physical activity and quality of life. measurements - done via telephone and the internet - will be collected pre-treatment, weekly during treatment period, immediately post treatment and then monthly during a 24-month follow-up period. discussion: the results of this study will constitute an important contribution to the body of knowledge of the respective interventions.

Eligibility criteria:
inclusion criteria: * satisfy dsm-iv (or dsm-v) criteria for depression, with depression being primary diagnosis * scoring within the interval 15-35 on the montgomery-åsberg depression rating scale (madrs) * living in sweden and being able to read swedish * access to computer with internet connection exclusion criteria: * currently receiving other psychological treatment * non-stable use of psychoactive medication * deemed to suffer from a too severe depression * deemed to suffer from other psychological disorder, e.g. psychosis, bipolarity etc.

Keywords: depression behavioral activation
open label ketamine treatment for major depressive disorder in veterans

Conditions: Major Depressive Disorder

Summary: medically healthy veterans ages 21-75 that have been diagnosed with depression will get up to 6 treatments of ketamine infusions, weekly. after treatment is completed, follow up will occur at 1 month, 3 months, and 6 months after completion of infusions to evaluate the longer term effects of ketamine.

a total of 25 depressed subjects between the ages of 21-75 who have current major depressive disorder without psychotic features by dsm-5 will be recruited. subjects will be accepted into the protocol after an opportunity to review and provide voluntary written informed consent and completion of a comprehensive medical and psychiatric history, physical examination, mental status examination, and routine laboratory assessments. patients will be recruited in outpatient settings to the refractory depression clinic. providers or refractory depression consult team will be informed if the patient may be eligible for participation in the ketamine protocol. subjects must have established care in the va connecticut healthcare system. if the veteran is interested, a screening visit for further evaluation for the ketamine protocol will be scheduled. veterans will receive up to 6 infusions for ketamine weekly, per pi discretion. the primary goal of this proposal is to test the effectiveness of repeated ketamine treatment (0.5 mg/kg; once or twice a week for up to 6 weeks; up to a total of 6 ketamine infusions). an open-label trial will be conducted that will include up to 25 veterans with mdd with a follow-up of 6 months. this open-label trial will allow us to examine the safety and tolerability of the ketamine treatment in this population and the long-term effects. all patients will receive usual standard care during this trial.

Eligibility criteria:
inclusion criteria: 1. male or female, 21-75 years old 2. current major depressive disorder without psychotic features by dsm-5 3. montgomery-åsberg depression rating scale (madrs) ≥ 20 4. able to provide written informed consent exclusion criteria: 1. current or past history of psychotic features or psychotic disorder 2. current or past history of delirium or dementia 3. current uncontrolled hypertension (systolic bp \> 170 mm hg or diastolic bp \> 100 mm hg) 4. unstable medical condition or allergy to ketamine or lorazepam---clinically determined by a physician 5. pregnant or nursing women, positive pregnancy test, or inadequate birth control methods in women of childbearing potential 6. positive opioid or illicit drug screen test (except marijuana)

Keywords: ketamine major depressive disorder
sustainability of move up lifestyle intervention

Conditions: Body Weight; Diet, Healthy; Physical Disability

Summary: in prior research the investigators have shown that the mobility and vitality lifestyle program for healthy aging and weight management (move up) was effective in producing a mean loss of \>= 5% body weight, with increased physical activity and reduced fatigue. the current study will pilot a modified and streamlined program to see if it will be similarly effective.

the investigators aim to test feasibility of community health worker delivery of a modified and streamlined lifestyle program in volunteer community settings and to provide pilot data to inform the design of future randomized controlled trials that may improve physical and mental health in older adults. the current objective is to: 1. adapt and pilot the previously studied 32-session, 13-month move up intervention to a streamlined 12-session (4-month) community-based translational behavioral weight management program. the pilot program will be delivered by trained community health workers (chws). 2. implement and evaluate the program's impact on weight and healthy lifestyle changes, including physical performance outcomes, at 2 sites, each with at least 6 eligible obese adults ages 60-75 years old.

Eligibility criteria:
inclusion criteria: 1. 60-75 years of age 2. bmi \>=27.0, but \<45.0 3. able to consent for participation and data collection. 4. medical clearance from physician/health care provider before session 2 in program. 5. ability to walk with or without assistive device. exclusion criteria: 1. past move up participant. 2. if weight loss in the past year is \>=10% body weight. 3. use of wheelchair; participant must be willing and able to increase physical activity. 4. uncontrolled diabetes mellitus (fbs \> 30 \& a1c \> 11%); to be assessed by physician on medical release. 5. uncontrolled hypertension (sbp \> 180/110) %); to be assessed by physician on medical release. 6. recent overnight hospitalization (past 6 months). 7. active treatment for cancer (including melanoma). 8. significant visual or hearing impairment. 9. significant cognitive disorder/relevant and significant psychiatric disorder (to be assessed on medical release). 10. inability to communicate in english/lack of translator. 11. currently enrolled in another research study that could impact study outcomes or interfere with either study. exclude if less than 12 months post-graduation from previously enrolled study. 12. currently enrolled in a weight loss program, such as weight watchers. 13. inability or unwillingness to attend the majority of sessions. 14. in the past year, participating in (other) ways of losing weight, such as bariatric surgery, prescription medications, or non-surgical interventions (reviewed by investigators). 15. unable to obtain medical clearance by session 2.
severe aortic stenosis and acquired von willebrand´s disease: the impact of desmopressin in valve-replacement surgery

Conditions: Acquired Von Willebrand Disease Secondary to Severe Aortic Stenosis; Heye´s Syndrome; Severe Aortic Stenosis

Summary: acquired von willebrand disease (type 2a) has been described in patients with severe aortic stenosis, the association of aortic stenosis and digestive bleeding due to this phenomena has received the name of heye´s syndrome. we propose that administering desmopressin (ddavp) in patients scheduled to aortic valve replacement surgery will reduce blood loss and transfusion rate. this was a pilot study

randomized controlled trial compared with placebo in a double blind fashion. subjects with severe aortic stenosis (transvalvular gradient \>50 mmhg or valvular area of lass than 1 cm2) scheduled for aortic valve replacement were enrolled. the day of surgery blood samples were taken in order to confirm diagnosis (factor viii activity and protein electrophoresis for von willebrand´s multimers) and then 0,3 mcg/k of ddavp or saline equally labeled as "study drug" were administered en 30 minutes a half hour before incision. blood loss, postoperative hematocrit and transfusion requirement were measured, plasma sodium was measured as a safety issue.

Eligibility criteria:
inclusion criteria: * severe aortic stenosis defined as mean transvalvular gradient greater or equal to 40 mmhg ot transvalvular area less than 1 cm2 * scheduled for aortic valve replacement surgery exclusion criteria: * combined surgery (plus coronary artery bypass graft or other valve replacement/plasty) * infective endocarditis * previously known haemostatic disorder * previous treatment with oral anticoagulants or iib-iiia inhibitors (we did not exclude those on acetyl-salicylic acid)

Keywords: acquired von willebrand disease severe aortic stenosis heye´s syndrome desmopressin von willebrand multimers
sound quality comparisons with different hearing aid couplings and venting systems

Conditions: Hearing Loss, Sensorineural

Summary: participants will be comparing the sound quality of their own voice and the sound quality of streamed music using universal couplings and a custom earmold with a dynamic vent.


Eligibility criteria:
inclusion criteria: * mild to severe bilateral sensorineural hearing loss * hearing must be symmetrical below 500 hz * must live within 30 miles of aurora il exclusion criteria: -
does myomectomy for intramural fibroid improve art outcome?

Conditions: Fibroid Uterus

Summary: intamural fibroids (myoma) do exist in some infertile women undergoing ivf treatment. there is controversy whether myomectomy before ivf treatment could improve ivf outcome. this trial will examine whether myomectomy in those patients could improve the results.

this study will include women who have intramural myoma ranging from 3-5 cm the participants will be randomly allocated into two groups. in group (1): myomectomy will be performed before art in group (2):women will have their trial of art without myomectomy in group a, art will be performed 3 months after myomectomy if the uterine cavity is not opened and 6 months after myomectomy upon inadvertent opening of the uterine cavity during surgery

Eligibility criteria:
inclusion criteria: * inclusion criteria: * women with intramural fibroid without any cavity involvement * age ˂ 35 years * i oncsi or ivf cycles * normal uterine cavity exclusion criteria: * exclusion criteria: * low ovarian reserve (afc \< 7 and or amh \< 1.1 ng/ml) * endometrioma * untreated hydrosalpinx * non obstructive azoospermia * any other cavitary lesions (asherman syndrome, mullerian anomalies) * recurrent implantation failure
olanzapine in the treatment of anorexia nervosa

Conditions: Anorexia Nervosa

Summary: this study compared 10 weeks of treatment with olanzapine versus placebo in adolescent females with anorexia nervosa-restricting type who were undergoing acute treatment on an inpatient unit or a day hospital program that specializes in the treatment of eating disorders.


Eligibility criteria:
inclusion criteria: * females, ages 12-23 exclusion criteria: * binge-purge type

Keywords: anorexia nervosa, treatment, adolescents, olanzapine
coronavirus disease of 2019 (covid-19) health education initiative for school safety

Conditions: COVID-19

Summary: the purpose of this study is to compare covid-19 knowledge, experiences, and health behaviors between participants who received the health initiative and those who did not.


Eligibility criteria:
inclusion criteria: * parents/guardians of students enrolled in: * arch creek elementary, fulford elementary * greynolds park elementary * sabal palm elementary * north miami middle school, * john f kennedy (jfk) middle school * north miami senior high * north miami beach high * booker t. washington high * able to read and write in english, spanish, or creole at a 5th grade level exclusion criteria: * does not speak: * english * spanish * creole
effect of remote ischemic preconditioning on cerebral circulation time in patients with severe carotid artery stenosis (rip-cct)

Conditions: Carotid Artery Stenosis

Summary: cerebral circulation time in patients with severe carotid artery stenosis was found to be associated with hyperperfusion syndrome. remote ischemic preconditioning can change the ability of cerebral autoregulation. the prospective, randomized controlled, blind outcome evaluation, multi-center study aimed to investigate the effect of remote ischemic preconditioning on cerebral circulation time in patients with severe carotid artery stenosis.


Eligibility criteria:
inclusion criteria: * age 18 years or older, regardless of gender; * patients with severe carotid stenosis eligible for stenting (70-99% stenosis confirmed by dsa); * non-responsible vessel stenosis \<50% if bilateral carotid stenosis or combined posterior circulation stenosis is present; * first dsa suggestive of ≥ 0.8 seconds difference (cct on the affected side - cct on the healthy side); * baseline modified rankin scale (mrs) ≤ 2 points. * signed the informed consent form. exclusion criteria: * baseline mrs ≥ 3 points; * severe long-segment calcification of the carotid artery, severe distortion of aortic arch branches, anatomical variation of the aortic arch, and etc, which are not suitable for stenting * spontaneous intracranial hemorrhage within 12 months; * previous severe stroke or myocardial infarction within 3 months; * active bleeding and coagulation disorders, which is contraindication to heparin and antiplatelet agents; * a large intracranial aneurysm that cannot be treated simultaneously; * severe insufficiency of vital organs such as the heart, lungs, liver and kidneys, or malignant tumors with an expected survival cycle of less than six months; * total occlusion of carotid artery without obvious cerebral ischemic symptoms * unable to tolerate anesthesia; * severe dementia; * uncontrolled hypertension ; * allergy to contrast media; * pregnancy; * being involved in studies with other drugs or instruments, etc; * contraindications to remote ischemic preconditioning, such as those with more severe soft tissue injuries, fractures or vascular injuries in the upper extremity, or peripheral vascular lesions in the distal upper extremity.
study of photodynamic therapy (pdt) in patients with central serous chorioretinopathy (csc)

Conditions: Central Serous Chorioretinopathy

Summary: the purpose of this study is to determine the safety and efficacy of pdt at 30% verteporfin dose in the treatment of csc.


Eligibility criteria:
inclusion criteria: * patients with csc * patients signed the icf * patients with course of csc less than 6 months * patients did not undertake any treatment for csc exclusion criteria: * patients with porphyria * patients allergic to verteporfin * pregnant or nursing women * poor patients compliance * sever liver dysfunction * dioptric media opacities which make it difficult to exam fundus
comparison between effect of enoxaparin and clopidogrel on improving pregnancy rate in icsi

Conditions: Female , Infertility

Summary: comparison between effect of enoxaparin and clopidogrel on improving pregnancy rate in icsi

study setting: assisted reproduction unit in ain shams university maternity hospital study population: patients underlying icsi in assisted reproduction unit in ain shams university maternity hospital intervention: after taking written informed consent, all patients recruited in the study will undergo, detailed medical history and complete clinical examination will be obtained along with necessary laboratory investigations and ultrasound findings the standard protocol of the assisted reproduction unit in ain shams university maternity hospital for induction of ovulation in icsi patients which it is the long protocol will be given for all patients in the study. endometrial and sub-endometrial blood flow for every patient in the 3 groups will be assessed by transvaginal ultrasound using medison sonoace r5 ultrasound machine, eight hours before giving the trigger, after they have completely emptied their bladders (2d power doppler will be performed). this will be repeated one week after the day of embryo transfer. endometrial blood flow will be detected by intra-endometrial or the adjacent sub-endometrial regions within 10 mm of the echogenic endometrial borders. double thickness of the endometrium will be measured (maximum distance between each myometrial/endometrial interface through the longitudinal axis of the uterus). the pulsatility index (pi) and resistance index (ri) of the endometrial arteries will be calculated. analysis will be used together with computer algorithms to form indices of blood flow within the endometrium. the parameters will be analyzed by software for: (i) resistance index (ri): the difference between maximal systolic blood flow and minimal diastolic flow divided by the peak systolic flow (s-d/s); (ii) pulsatility index (pi): the difference between maximal systolic blood flow and minimal diastolic flow divided by the mean flow throughout the cycle (s - d/mean); (iii) the ratio between peak systolic flow and lowest diastolic flow (s/d). these three parameters express the resistance to flow from the point of measurement downstream. the patients will be divided into three groups according to the condition of the endometrial blood flow: in group 1, no endometrial blood flow is detected; group 2 has sub-endometrial blood flow detected, and group 3 has both endometrial and sub-endometrial blood flow detected. pregnancy will be assessed by serum b-hcg test after fourteen days of having embryo transfer, then two weeks later trans-vaginal ultrasound will be performed to insure the presence of gestational sac.

Eligibility criteria:
inclusion criteria: age :20-35yrs. 1. embryo transfer at 3rd or 5th day after ovum pick up. 2. the transferred embryos are in the four cell stage ,eight cell stage, sixteen cell stage or blastocyst stage. exclusion criteria: 1. age \ 35 yrs old. 2. chronic medical disease. 3. single embryo transfer. 4. previous icsi failure.
the effect of sex education and counseling given to women with stomia with the ex-plissit model on sexual life

Conditions: Stoma Colostomy; Stoma Ileostomy

Summary: in this study, it was aimed to determine the effect of sexual education and counseling given to women with stoma with the ex-plissit model on their sexual life quality and sexual life satisfaction. h1: female patients with permanent stoma who were given sexual education and counseling with the ex-plissit model had a higher quality of life score measured by the sexual quality of life scale. h2: female patients with permanent stoma who were given sexual education and counseling with the ex-plissit model had higher mean scores of sexual life satisfaction.


Eligibility criteria:
inclusion criteria for research * permanent stoma for at least 6 months * not receiving active surgical treatment, chemotherapy and radiotherapy (at least 6 previous treatments have been completed) * married * agreeing to participate in the research and obtaining written permission, * over 18 years research exclusion criteria * using antidepressants or using sedatives * having a diagnosed psychiatric problem, * women with diagnosed sexual dysfunction will not be included in the study. exclusion criteria from research * do not complete the study, * surgical treatment, radiotherapy or chemotherapy started due to an urgent necessity during the working process, patients who die during the study will be excluded.
comparison of lingualized and full bilaterally balanced articulation

Conditions: Jaw, Edentulous

Summary: the purpose of this study is to find the difference between patient satisfaction, masticatory performance and cost between two occlusal schemes for complete denture prosthodontics.

two occlusal scheme applied to complete denture prosthodontics has been compared in rct. this will have clinical benefit for deciding which occlusal scheme is better according to patient conditions. it will also have impact on dental educational curriculum.

Eligibility criteria:
inclusion criteria: * edentulous both maxilla and mandible, asking for new denture fabrication exclusion criteria: * psychiatric problem * those who have difficulty answering the questionnaire * oral cancer * radiation experience

Keywords: complete dentures patient satisfaction treatment cost