Kornimate/medical-research-clean huggingface dataset:
immersive virtual reality in post stroke

Conditions: Balance; Stroke; Physical Therapy; Virtual Reality

Summary: physiotherapy intervention programs in the post-stroke patient should develop strategies to assess functional deficit, prevent poorly adaptive plasticity and maximize functional gain. for relearning and functional training, the required activities require motor control and must comply with the following principles: movements close to normal, muscular activation, movement conduction, focused attention, repetition of desired movements, specificity of training, intensity and transfer. these principles underlie the most widely used conventional physiotherapy intervention programs in the hospital setting. advances in technology have made it possible to start using immersive vr in the therapeutic approach to various pathologies that affect motor function.

physiotherapy intervention programs in the post-stroke patient should develop strategies to assess functional deficit, prevent poorly adaptive plasticity and maximize functional gain. for relearning and functional training, the required activities require motor control and must comply with the following principles: movements close to normal, muscular activation, movement conduction, focused attention, repetition of desired movements, specificity of training, intensity and transfer. these principles underlie the physiotherapy intervention programs specifically most used in the hospital setting. main aims 1-to determine if the designed immersive vr training program is better in the short term (15 sessions) and in the medium term (30 sessions) than the conventional physiotherapy training with respect to the change of the parameters related to the static balance in sitting and standing and dynamic balance in post-stroke patients. secondary aims 2. to determine the efficacy in the short term (15 sessions) and in the medium term (30 sessions) of immersive vr systems compared to conventional physiotherapy procedures regarding the quality of life associated with stroke, the degree of independence and autonomy . 3. to determine the safety of the application of training programs in immersive vr settings in post-stroke subjects with respect to the number of adverse effects produced. 4. determine prognostic factors associated with insufficient improvement (less than moderate change) after stroke treatment with the designed immersive vr program and with conventional physiotherapy treatment.

Eligibility criteria:
inclusion criteria: * adults\> 18 years and \<80 years. * diagnosis of hemiparesis or post-stroke hemiplegia. * minimum score of 2 points on item 3.2 of the berg scale, which establishes that the patient can remain in a sitting position for 30s without help. exclusion criteria: * aphasia, scores over 45 on the mississippi aphasia screening test. * cerebellar pathology. * hemineglect or previous neurological disorder. * visual disturbances that prevent the use of vr glasses. * moderate cognitive decline, scores less than 43 on the mini-mental state examination. * previous musculoskeletal disorders that make it difficult or impossible to balance sitting and standing or walking.
mindfulness - based intervention in the treatment of fatigue in patients with primary biliary cholangitis

Conditions: Primary Biliary Cholangitis

Summary: to assess the efficacy of mindfulness-based intervention (mbi) intervention in the treatment of moderate or severe fatigue in patients with primary biliary cholangitis (pbc).

aim 1: to assess the efficacy of mindfulness-based intervention (mbi) in the treatment of moderate or severe fatigue in patients with primary biliary cholangitis (pbc). hypothesis: mbi is feasible in pbc patients with fatigue and will result in improvement in symptoms of fatigue. aim 2: to assess the impact of mbi in physical activity levels, daytime somnolence, autonomic symptoms, functional status, cognitive dysfunction and anxiety and depressive symptoms of patients with pbc with moderate or severe fatigue. hypothesis: mbi will result in an improvement in physical activity levels, daytime somnolence, autonomic symptoms, functional status, cognitive dysfunction and anxiety and depressive symptoms in patients with pbc who have moderate or severe fatigue. aim 3: to evaluate the effects of mbi on candidate markers and/or cytokines of fatigue and physiological stress, including hepatic panel, antimitochondrial (ama) titers, il-1β, il-6, tnfα, cortisol, leptin, crp, bdnf, mif, and cd74 levels and other relevant markers. hypothesis: mbi will result in a decrease of levels of above mentioned markers of fatigue and physiological stress in patients with pbc who have moderate or severe fatigue.

Eligibility criteria:
inclusion criteria: * primary biliary cholangitis as defined by previously published criteria * on stable therapy with udca for at least 6 months before enrollment * primary biliary cholangitis-40 fatigue domain score \> 33 * the ability to provide written consent exclusion criteria: * a known medical condition or metabolic disorder sufficient to explain fatigue such as anemia, thyroid disease, renal failure, use of beta-blockers and untreated depression * active drug or alcohol use or history of drug and/or stimulant abuse * history of psychosis * modification of treatment for underlying pbc in the preceding six months * other serious coexistent conditions such as pre-existing advanced malignancy or severe cardiopulmonary disease which would be expected to limit their life expectancy * anticipated need for transplantation in one year (mayo survival model \<80% one-year survival without transplant) or meld above 15 * recurrent variceal bleeding, presence of diuretic-resistant ascites, or spontaneous encephalopathy * non-proficiency in english
chronic kidney disease & therapeutic exercise

Conditions: Kidney; Exercise

Summary: the aim of this study is to evaluate the therapeutic exercise effects in patients with chronic kidney disease. an interventional prospective study is carried out. a sample of 9 patients with chronic kidney disease is recruited. the kidney function (creatinine clearance as main outcome) is measured at baseline and 1 month after treatment start.


Eligibility criteria:
inclusion criteria: * patients with chronic kidney disease exclusion criteria: * cognitive impairment and non signed consent inform form.
the safety and efficacy of micro-energy ultrasound therapy in the treatment of female stress urinary incontinence

Conditions: Female Stress Urinary Incontinence

Summary: the safety and efficacy of micro-energy ultrasound therapy in the treatment of female stress urinary incontinence: a multi-center randomized trail

1. study purpose: to evaluate the safety and efficacy of micro-energy ultrasound therapy in the treatment of female stress urinary incontinence 2. study design: this is a randomized, double-blind, controlled, multi-center clinical trial 3. study subjects: females with mild to moderate stress urinary incontinence 4. number of subjects: 60 5. study center: the second affiliated hospital, school of medicine, zhejiang university 6. treatment methods: test group: after installing the disposable treatment head coat, the pelvic floor muscles, ligaments, etc. were treated with an ultrasonic therapeutic apparatus; after the treatment, the disposable treatment head coat was removed. patients were treated twice a week for 6 weeks. control group: the placebo was treated with an ultrasound therapy device and used in the same manner as the test group.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed as mild to moderate female stress urinary incontinence in our hospital; 2. other conservative treatments are ineffective or have poor results, and the operator is not considered for the time being; 3. volunteer to participate in this clinical trial, complied with the requirements of this study and signed the informed consent form. exclusion criteria: 1. other types of urinary incontinence; 2. blood routines indicate acute and chronic blood system diseases; 3. b-ultrasound suggests other gynecological diseases; 4. combine uncontrollable diseases such as diabetes, hypertension, and cardiovascular diseases; 5. previous or current history of pelvic surgery and radiotherapy and chemotherapy; 6. the investigator determined that it is not suitable for this clinical trial.

Keywords: female stress urinary incontinence
safety and tolerability of ascending intravenous doses of pf-05231023 in adult subjects with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: this is a trial in subjects with type 2 diabetes mellitus to study the safety, tolerability and pharmacokinetics of multiple ascending doses of pf-05231023.


Eligibility criteria:
inclusion criteria: * male subjects and female subjects of non-childbearing potential between the ages of 30 and 70 years, inclusive, with a historical diagnosis of type 2 diabetes mellitus, diagnosed according to the american diabetes association guidelines. subjects who have other conditions but are well controlled by either diet or medications may be included as well (for example, a subject with high cholesterol level on appropriate treatment is eligible). * body mass index (bmi) of 25 to 35.5 kg/m2, and a total body weight \>50 kg (110 lbs). exclusion criteria: * evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing). * diagnosis of type 1 diabetes mellitus. * evidence of diabetic complications with significant end organ damage

Keywords: type 2 diabetes safety multiple dose intravenous
effects of egcg-enhanced extra virgin olive oil on endothelial function

Conditions: Atherosclerosis

Summary: this study is being done to determine if the use of egcg-enhanced extra virgin olive oil in a daily diet will improve endothelial function.

patients will be randomized to receive either placebo roo (refined olive oil) or study solution egcg-evoo (egcg enhanced extra-virgin olive oil) over the four month study period.

Eligibility criteria:
inclusion criteria: * patients will be included in the study if they have an abnormal endothelial function study. this is defined at our institution as an rh-pat index of less than 2. patients will undergo two rh-pat analyses and included abnormal values are obtained on either one or both tests. only patients who provide written informed consent will be included. exclusion criteria: * patients with normal baseline endothelial function studies defined as rh-pat index \>2 will be excluded. patients with uncontrolled hypertension \>180/100 while on medication on initial evaluation will also be excluded.
study of the wear of a highly cross-linked polyethylene acetabular doped with vitamin e and coated with titanium in total hip replacement

Conditions: Total Hip Replacement

Summary: the total hip replacement, with over 120,000 cases per year in france, provides short term, excellent functional results and a significant improvement in quality of life, in almost all cases. however, the observation has shown that the lifetime of the implants is limited due to aseptic loosening. one of the factors associated with these failures is a peri-prosthetic osteolysis wherein the polyethylene wear debris (pe) have been implicated. several solutions have been proposed: change the friction torque (hard-hard pairs using ceramic or metal on the two components of the couple) or improving quality polyethylene. improving the resistance of polyethylene wear is the primary objective evaluated in this study.


Eligibility criteria:
inclusion criteria: * patients aged men and women 18 to 75 years * with a primary or secondary osteoarthritis or osteonecrosis * having a functional disorder requiring the installation of a total hip prosthesis of primary exclusion criteria: * patients aged 76 years or more * pregnant or desiring to be for the duration of the study * minors or adults protected * repeated hip replacement * cephalic prosthesis recovery or intermediate * repeated cupules * primary or secondary malignant tumor of the hip
the effects of an antioxidant formulation on ocular blood flow

Conditions: Primary Open Angle Glaucoma

Summary: the objective is to evaluate the effects of an antioxidant formula versus placebo on ocular blood flow in a randomized double-blind, crossover design. based upon preliminary data, it is hypothesized that a dietary supplement containing a variety of ingredients with antioxidant properties will, compared to placebo, increase ocular perfusion pressure, retrobulbar, retinal capillary and choroidal blood flow, and maintain these effects over the course of the treatment period.


Eligibility criteria:
inclusion criteria: * age 30 years or older. * confirmed diagnosis of open angle glaucoma by glaucoma specialist in the study eye, as evidenced from criteria representative of glaucomatous optic nerve damage such as specific optic disc or retinal nerve fiber layer structural abnormalities and/or visual field abnormalities. * best corrected visual acuity at 20/60 or better in study eye. * willingness to avoid caffeine and smoking for 12 hours before and during the study visits. exclusion criteria: * history of acute angle-closure or a narrow, occluding of anterior chamber angle by gonioscopy. * history of chronic or recurrent inflammatory eye diseases or signs of intraocular trauma and/or unreliable applanation tonometry. * severe, unstable or uncontrolled cardiovascular, renal or pulmonary disease * history of/or current renal or hepatic impairment. * history of/or current bronchial asthma, severe chronic obstructive pulmonary disease, sinus bradycardia, second or third degree atrioventricular block, or cardiogenic shock. * recent surgery or surgery planned near study timeline * history of bleeding disorder * use of blood thinning medications * use of specified dietary supplements for three weeks prior to study entry and throughout study period.

Keywords: primary open angle glaucoma intraocular pressure ocular perfusion pressure retrobulbar blood flow retinal capillary blood flow choroidal blood flow
estimation of the prevalence of hiv, hepatitis c and hepatitis b infection among detainees in the nîmes administrative detention center

Conditions: HIV Infections; Hepatitis C; Hepatitis B

Summary: people in administrative detention centers often come from areas of medium or high hiv, hepatitis c \& b endemic, and are often unaware of their serological status. currently, hiv, hepatitis c \& b screening is not systematically performed at the cra of nîmes, and when performed, serological tests are used. the main disadvantage of this method is the length of time it takes to obtain the results, with subjects frequently discharged before receiving their results. to improve the care of these vulnerable persons, the aim of this study is to estimate the prevalence of hiv, hepatitis c and hepatitis b in the detainees of the administrative detention center of nîmes, by systematically screening with a rapid diagnosis test. in case of a positive rapid diagnosis test test, a serology test will confirm the rapid diagnosis test result.


Eligibility criteria:
inclusion criteria: * the patient must have given their free and informed oral consent * patient detained in the nîmes administrative detention center exclusion criterion • it is impossible to give the subject informed information
neoadjuvant chemotherapy with pisoxo for locally-invaded-gastric cancer (ligc)

Conditions: Stomach Cancer; Gastric Cancer

Summary: the main purpose of this study is to compare the safety and efficacy of pipac+sox+olaparib for locally-invaded-gastric cancer (ligc) patients in china. to obtain preliminary results for designing a new phase ii/iii randomized controlled trial.

peritoneal metastases is the main cause of relapse and death after surgery in patients with serosa positive or locally-invaded-gastric cancer (ligc). recent researches showed that pipac and olaparib are effective to control peritoneal metastases in different malignant diseases but it has not been tested for gastric cancer patients. the main purpose of this study is to compare the safety and efficacy of pipac+sox+olaparib for locally-invaded-gastric cancer (ligc) patients in china. to obtain preliminary results for designing a new phase ii/iii randomized controlled trial.

Eligibility criteria:
inclusion criteria: * histology confirmed non-obstructive adenocarcinoma of the stomach or esophagogastric junction. * clinical stage: ctnm: t4b and or n0-3 m0 * performance status: eastern cooperative oncology group (ecog) ≤ 2 (normal to symptomatic but in bed less than half the day) * clinically fit for systemic chemotherapy and gastric cancer surgery, i.e. adequate renal, hepatic, hematologic, and pulmonary function. * written informed consent exclusion criteria: * clinically unfit for systemic chemotherapy and gastric cancer surgery, i.e. uncontrolled cardiac disease, or other clinically significant uncontrolled comorbidities, unable to undergo general anesthesia * distant metastases * locally advanced inoperable disease (clinical assessment) * relapse of gastric cancer * prior chemo or radiotherapy * inclusion in another clinical trial * known contraindications or hypersensitivity for planned chemotherapy
the anaesthesiological approach to varicocele correction in outpatients setting: an observational analysis

Conditions: Varicocele

Summary: the aim of this observational study was to evaluate, based on the intraoperative anesthetic that is routinely carried out at the department of day surgery, the difference in timing of the patient's discharge from the hospital (ie when the patient has autonomous demabulation and urination spontaneous) in patients undergoing correction of varicocele according marmar.


Eligibility criteria:
inclusion criteria: * male * asa i-ii * no mental alteration exclusion criteria: * chronic pain * allergies to local anaesthetics, acetaminophen,oppioids * asa iii - iv * postoperative discharge to icu * epatic or renal failure * mental status alteration * coagulopathy
efficacy study of rectus sheath block to control postoperative pain

Conditions: Pain, Postoperative

Summary: the aim of this study is to evaluate the effect of the ultrasound guided rectus sheath block (rsb) on both intraoperative sevoflurane consumption and postoperative analgesia.

prospective, randomized study.forty patients with american society of anaesthesiologists (asa) i-ii physical status, aged 3-15 years.patients are randomly allocated into two groups and are administered general anesthesia and before the beginning of surgery ultrasound guided rsb with 0.2 ml.kg-1, 0.25% of levobupivacaine and thirty minutes before the surgery the loading dose of morphine of 0.1 mg.kg-1 intravenously are received in group rsb and group m, respectively. patient controlled analgesia (pca) device with 0.01 mg.kg-1 bolus dose of morphine and 30 minutes lockout interval is set up postoperatively in both groups.

Eligibility criteria:
inclusion criteria: * asa physical status i-ii * 3-15 years of age children * abdominal surgery including liver, gall bladder, spleen, small intestine, cecum, colon, rectum, intra-abdominal masses, umbilical, paraumbilical, and inguinal hernia with transverse incision exclusion criteria: * asa physical status iii and above * parents who did not consider to participate in the study * having systemic (septicemia, bacteremia) or local infection, bleeding and shock, predisposition for bleeding and anticoagulant therapy given, central nervous system disease, allergy to local anesthetics, severe respiratory, hepatic, and renal failure

Keywords: laparotomy levobupivacaine patient controlled analgesia
effects of general anesthesia on quality of recovery after transaxillary endoscopic breast augmentation

Conditions: Breast Augmentation; Inhalation Anesthesia; Total Intravenous Anesthesia; Quality of Recovery

Summary: among aesthetic or cosmetic surgeries, breast augmentation was the most frequently performed and the endoscopic transaxillary approach has become the preferred incision for asian women. as breast augmentation must be performed under general anesthesia accompanied by its effects and potential complications, types of general anesthesia may affect the quality of recovery. currently, the two most common techniques of general anesthesia are inhalation anesthesia (ih) and total intravenous anesthesia (tiva). the effects of these types of general anesthesia on the quality of recovery have been investigated for numerous surgical procedures. however, no prior studies have analyzed different types of anesthesia used for performing transaxillary endoscopic breast augmentation. this prospective, parallel, randomized controlled study will evaluate the effects of inhalation anesthesia vs. total intravenous anesthesia on the quality of recovery in patients undergoing transaxillary endoscopic breast augmentation.


Eligibility criteria:
inclusion criteria: * patients are appropriate for undergoing transaxillary endoscopic breast augmentation * age between 20-65 years * physical status i or ii as defined by the american society of anesthesiologists (asa) physical status classification system exclusion criteria: * having difficulty reading or hearing * diagnosed with addictive disorder * diagnosed with psychiatric disorder * physical status iii-vi as defined by the asa physical status classification system * presence of acute infection or inflammatory condition (e.g., fever).
compliance with eras and five year survival after colorectal cancer treatment

Conditions: Colorectal Cancer; ERAS

Summary: the enhanced recovery after surgery (eras) protocol has transformed perioperative care, representing a significant paradigm shift in managing colorectal cancer patients. while the immediate benefits of enhanced recovery after surgery (eras) in expediting postoperative recovery are well-documented and widely acknowledged, it is essential to investigate its long-term implications, particularly its influence on survival rates. the aim of this study will be to analyse the impact of compliance with the eras protocol on long- term outcomes after laparoscopic colorectal resection.

the aim of this study will be to analyse the impact of compliance with the eras protocol on long- term outcomes after laparoscopic colorectal resection. the study will be designed as a prospective observational study to compare the long-term effects of surgical treatment of colorectal cancer in two groups of patients: those with high compliance with the eras protocol (≥80%) and those with low compliance with the eras protocol (\&lt;80%). the primary outcome of the study will be the 5-year survival rate. the inclusion criteria for group 1 will involve 128 patients with eras compliance below 80%. conversely, group 2 will consist of 340 patients, all of whom achieved a compliance rate of at least 80%. the correlation between compliance with the eras protocol and 5-year survival will be assessed using the kaplan-meier method with log-rank tests. additionally, survival analysis will be conducted separately for groups with varying cancer stages.

Eligibility criteria:
inclusion criteria: * patients undergoing treatment for colorectal cancer exclusion criteria: * primary open or emergency surgery, * transanal endoscopic microsurgery (tem), * stage iv of the disease according to the american joint committee on cancer (ajcc) classification, * multivisceral resection, * concomitant inflammatory bowel diseases, * intensive care unit stay immediately after surgery * lost-to-follow-up patients.