Kornimate/medical-research-clean huggingface dataset:
using two different attachments in mandibular implant overdenture cases in order to retention and patient satisfaction

Conditions: Edentulous Alveolar Ridge; Complete Edentulism; Dental Implant; Attachments; Implant Supported Overdenture; Edentulous Mouth; Edentulous Jaw

Summary: the goal of the clinical trail is to evaluate the efficacy of bar- ot equator attachment on retention and patient satisfaction in comparison to the standard technique using bar- clip attachment. patients will visit the clinic after the surgery and after the attachment insertion for check ups and during the follow up periods ( at denture insertion, 3 months and 6 months)

patients will receive upper complete dentures and lower complete overdentures. the upper complete denture will be mucosa supported and the lower complete denture will be supported and retained for all patients by two dental implants in the inter-foraminal region. patients will be divided into two equal groups; group i will be retained by bar-clip attachment, while group ii will be retained by bar- ot equator attachment. both groups will be functionally loaded after three months of insertion. retention of lower denture will be measured using digital force gauge and patient satisfaction was evaluated with a standard 5-point liker scale questionnaire. all parameters will be measured at denture insertion, 3 month, and 6 month later.

Eligibility criteria:
inclusion criteria: * all patients age must range from 60- 70 years old. * all patients' ridges should be covered with firm mucosa free from any signs of inflammation or ulceration and exhibit adequate height and width of the residual alveolar ridge. * patients should be free from any metabolic or bone disorder that contraindicate implant installation. * all patients must have sufficient inter arch space exclusion criteria: 1. patients with oral or systemic diseases. 2. patients with xerostomia or excessive salivation. 3. patients with parafunctional habits (bruxism or clenching). 4. heavy smoker or alcoholic patients. 5. patients with history of temporo-mandibular dysfunction. 6. patients with brain disorders or psychiatric disorders

Keywords: dental implants completely edentulous patients edentulous ridge
a new protocol for continuous vancomycin infusion dosing.

Conditions: Sepsis; Vancomycin Treatment

Summary: this observational study prospectively collect data on chosen dosing, renal function, measured plasma concentrations and adherence to the recommended clinical protocl for icu patients treated with continuous vancomycin infusion.


Eligibility criteria:
inclusion criteria: - start of continuous vancomycin infusion during the course of intensive care and at least one measurement of plasma concentration. exclusion criteria: * vancomycin treatment within 96 h before admission to the unit. * vancomycin treatment started with intermittent bolus infusions.
preoperative immunonutrition in normonourished patients undergoing fast-track laparoscopic colorectal surgery

Conditions: Colorectal Cancer

Summary: immunonutrition (in) appears to reduce infective complications and in-hospital length of stay (los) after gastrointestinal surgery. more specifically, it seems to be beneficial also in colorectal cancer surgery. potential benefits of combining preoperative in (pin) with protocols of enhanced recovery after surgery (eras) in reducing los in laparoscopic surgery are yet to be determined.


Eligibility criteria:
inclusion criteria: * laparoscopic colorectal resection for cancer following eras protocol * \>18 years old * elective setting exclusion criteria: * age below 18 * malnutrition * inflammatory bowel disease * acquired or congenital immunodeficiency * preoperative infection * asa iv * pregnancy * emergency setting * conversion to open surgery * multivisceral resections
apixaban app study

Conditions: Atrial Fibrillation

Summary: the aim of this clinical trial is to evaluate whether the medication reminder app and video call can improve medication adherence to apixaban in patients with af and comorbidities. patients with af and comorbid heart disease taking apixaban who meet the inclusion criteria will be randomised 1:1 to a treatment arm using a medication reminder app and bi-weekly video education and a control arm using the medication reminder app alone to compare medication adherence. patients in both groups will use the medication app, but only the treatment group will receive additional education and feedback via video call every two weeks to reinforce the use of the medication app and medication reminders with video education. the study aims to assess the change in adherence between the two groups at week 8.


Eligibility criteria:
participants must meet all of the following criteria: adults aged 19 years or older with a diagnosis of atrial fibrillation (af) presence of at least one of the following cardiovascular or metabolic comorbidities: a. heart failure b. hypertension c. coronary artery disease d. peripheral arterial disease e. diabetes mellitus f. stroke g. other cardiac diseases requiring treatment currently taking or planning to initiate oral anticoagulation therapy with apixaban able to use a smartphone with an android operating system voluntarily provided written informed consent to participate in the clinical trial after being adequately informed of its purpose, procedures, and potential risks 2. exclusion criteria participants will be excluded if any of the following conditions apply: creatinine clearance (ccr) \< 15 ml/min presence of moderate to severe mitral stenosis history of mitral valve repair or replacement clinically significant history of alcohol or substance abuse deemed by the investigator to be legally or psychologically unsuitable for participation in the clinical trial participation in another clinical trial involving investigational drugs within 4 weeks prior to screening declines or is unwilling to provide informed consent for participation in this study

Keywords: atrial fibrillation mobile application digital health medication adherence
fibroids in women of reproductive age and women pregnancy

Conditions: Fibroids

Summary: dydrogesterone multivitamin nature treatment of fibroids in women of reproductive age and women pregnancy to lost the size fibroids.

uterine fibroids are a very common finding in women of reproductive age. but may fibroids grow in the first trimester pregnancy. clinically has shown that: uterine fibroids are associated with an heavy or prolonged menstrual periods. abnormal bleeding between menstrual periods. uterine fibroids are associated with an increased rate of spontaneous miscarriage, preterm labor, placenta abruption, malpresentation, labor dystocia, cesarean delivery, and postpartum hemorrhage, pain is the most common complication of fibroids during pregnancy. can usually be controlled by conservative treatment on dydrogesterone multivitamin nature.

Eligibility criteria:
inclusion criteria: * procedure to treatment of fibroids in pregnancy and in women desiring future fertility. exclusion criteria: * whether or not you are having symptoms from the fibroids * if you might want to become pregnant in the future * the size of the fibroids * the location of the fibroids * your age and you might be

Keywords: fibroids
physical activity training program for patients with alzheimer's dementia

Conditions: Dementia

Summary: the purpose of this study is to determine if a home based physical activity training program for patients with alzheimer's dementia has effects on clinical and neurobiological parameters.


Eligibility criteria:
inclusion criteria: * age \>55 years * german is the dominant language (necessary for neuropsychological testing) * minimum of 8 years formal school education * caregiver (e.g. spouse) living at home with participant * physical examination does not reveal contraindications to physical activity * stable dose of pharmacological dementia treatment according to german guidelines (dgppn) with acetylcholinesterase inhibitor or memantin or combination for at least 6 months * no other medication that could influence cognitive functioning (e.g. benzodiazepines, sleep aids, neuroleptics) exclusion criteria: * history of neurological or psychiatric disease other than ad * history of substance abuse disorder * history of electroconvulsive therapy (ect) during the last 6 months * structural brain deficits diagnosed in the mri scan, also without clinical relevance (incidental finding) * pacemaker, artificial heart valve, insulin pump or other medical implants * average steps/day are above 10.000 steps/day
atrial fibrillation in patients receiving ibrutinib

Conditions: Leukemia, Chronic Lymphatic; Mantle Cell Lymphoma

Summary: ibrutinib (a tyrosine kinase inhibitor targeting bruton) is a standard of treatment in haematology. according to retrospective data, atrial fibrillation and systemic hypertension are common ibrutinib-related advserse events. the investigators aim at prospectively establishing the incidence of thesedrug related advsere events through clinical monitoring and attempt at identifying populations at risk.


Eligibility criteria:
inclusion criteria: * all patients deem to start ibrutinib therapy exclusion criteria: * past history of ibrutinib therapy

Keywords: atrial fibrillation haematology systemic hypertension prognosis heart
twin block appliance in incremental versus maximum bite advancement in skeletal class ii

Conditions: Mandibular Retrognathism; Mandibular Hypoplasia

Summary: the aim of this study is to compare to different protocols to treat class ii malocclusion in growing subjects using the twin block appliance

* patients will be clinically and radio-graphically examined for eligibility * eligible patients will be randomly assigned to one of two groups: * control group: twin block appliance fabricated to maximum bite advancement group * intervention group: twin block appliance fabricated for incremental bite advancement group * records will be taken and impressions will be made and poured. in the control group, bite registration will be made with maximum mandibular advancement. in the intervention group, bite registration is made to habitual bite to make a modified twin block. * patients will be recalled every 6 weeks for 8 months for monitoring and reactivation of the appliance.

Eligibility criteria:
inclusion criteria: * growing female patient * skeletal class ii malocclusion due to deficient mandible * overjet of 7 to 10 mm * short or normal vertical facial pattern * no previous orthodontic nor orthopedic treatment exclusion criteria: * syndromes or chronic illness * skeletal class ii malocclusion due to excessive maxilla * vertical skeletal growth pattern * habits

Keywords: twin block bite advancement growth modification
translation and cultural adaptation of the groningen frailty indicator (gfi) in patients with hip fracture

Conditions: Frailty Syndrome; Hip Fractures

Summary: this study attempts to the translation and the cultural adaptation of the groningen frailty indicator (gfi) questionnaire in the greek population in patients suffering from hip fracture.

frailty indicates a state of vulnerability in terms of poor health outcomes, such as mortality, hospitalization, institutionalization and loss of function in one or more domains (i.e. physical, psychological, cognitive and social domains). frailty is not only associated with poor quality of life and life satisfaction but also has an effect on health care demands, as the number of frail people in our aging population will increase. current literature suggests that frailty is a common condition among elderly patients with hip fracture. ageing has been associated with a decline in physiological reserves which impedes the body's ability to withstand and recover from minor and major challenges, such as the hip fracture. hence, accurate diagnosis of frailty seems mandatory. the groningen frailty indicator (gfi) questionnaire is a feasible, reliable and valid self-assessment tool. this study will provide the first official greek translation and cultural adaptation of the gfi according to the ispor (international society for pharmacoeconomics and outcomes research) guidelines.

Eligibility criteria:
inclusion criteria: * adult patients over 65 years old with hip fractures undergoing surgery * an asa (american society of anesthesiologists) ps (physical status) i to iii * non-institutionalized * able to communicate orally or in writing * consent to participate exclusion criteria: * refused to participate * pathological hip fractures * institutionalized * patients with hip fracture treated conservatively * patients with severe cognitive dysfunction * patients with insufficient knowledge of the greek language

Keywords: frailty syndrome hip fractures cultural adaptation translation
trimodal prehabilitation for cystectomy patients to enhance post-operative care

Conditions: Bladder Cancer; Nutrition Aspect of Cancer

Summary: trimodal prehabilitation is a preoperative three-tiered (trimodal) approach to optimizing physical and mental health. it has been found to successfully improve functional recovery in patients undergoing colorectal surgery following an evidence-based enhanced-recovery pathway (erp). it is unknown whether the same program is effective in patients undergoing a similar surgery for bladder cancer (radical cystectomy). objective: to evaluate the appropriateness of a standardized prehabilitation program for implementation into an enhanced recovery pathway for cystectomy patients and determine whether prehabilitation facilitates earlier recovery of functional capacity. hypothesis: prehabilitation will ultimately improve recovery of functional capacity, clinical and patient-centered outcomes in patients undergoing radical cystectomy for bladder cancer. design: participants will follow an 8-week trimodal prehabilitation program consisting of exercise therapy combined with nutritional counseling, protein supplementation, and psychological care; they will be compared to a cohort of participants following erp care alone. conclusion: the proposal will provide insight into the feasibility and effectiveness of trimodal prehabilitation for radical cystectomy patients and may ultimately lead to improved clinical outcomes and reduced morbidity.


Eligibility criteria:
inclusion criteria: 1. male or female ≥ 18 years of age at time of consent for surgery. 2. documentation of bladder cancer diagnosis as evidenced by diagnostic imaging and biopsy. 3. may or may not receive adjuvant therapy. 4. written informed consent obtained from subject exclusion criteria: 1. presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient or adherence to the program. this includes: 1. american society of anesthesiologists (asa) health class status 4-5; 2. co-morbid medical, physical, and/or mental conditions including dementia, disabling orthopedic and neuromuscular disease, psychosis; 3. severe cardiac abnormalities, end-stage organ disease, sepsis, or morbid obesity (bmi greater than 35); 2. undergoing radical cystectomy for a reason other than bladder cancer. 3. poor comprehension of english or french 4. screened by total cardiology staff and determined to be inappropriate for prehabilitation at their facility.

Keywords: cystectomy nutrition physiotherapy prehabilitation enhanced recovery after surgery
lido workset study

Conditions: Multiple Sclerosis

Summary: this is a single-site, pilot study. in this study, we hope to learn if the lido workset is a sensitive measure of limb spasticity in patients with multiple sclerosis (ms). the lido workset is a fda approved, non-invasive device which has been used to assess motor function and spasticity. the testing will take approximately 25 minutes. subjects will lie down on a table and have a leg attached to the lido workset device arm. the lido workset will move the leg back and forth many times at different speeds. the lido workset will also analyze resistance to passive (while subject is not moving or resisting movement) movement of the wrist and knee.

the information gathered from testing individuals with spasticity due to multiple sclerosis with the lido workset has been important in making adjustments to the lido workset to show a greater degree of sensitivity in assessing varying degrees of spasticity. healthy control subjects will be used to compare the spasticity data of multiple sclerosis subjects with subjects with normal muscle tone to determine the sensitivity of the lido measurements. the testing will be performed one time for each patient and will take approximately 25 minutes. the servo-controlled torque motor system will analyze resistance to passive movement of the knee. this testing may be repeated for a group of randomly selected subjects from both the ms subjects and control subjects. the testing for this subset of subjects will be done as follows: first session, second session one week after the first session, third session three weeks after the first session. the total length of time for participation in this study may be up to three weeks. this additional testing will be done in order to compare the results with the lido data obtained at similar timepoints from the subjects enrolled in the cannabis for spasticity in ms study. each subject will be given the option to participate in the extended testing or to decline.

Eligibility criteria:
inclusion criteria: * must have a diagnosis of multiple sclerosis and * must have some degree of spasticity or * must be a healthy control subject * ability to give informed consent exclusion criteria: * patients with any life-threatening or unstable clinically significant disease * patients with other causes of reduced range of motion of the knee or wrist

Keywords: multiple sclerosis spasticity
a prospective, non-interventional study of jakavi® (ruxolitinib) treatment in patients with polycythemia vera

Conditions: Polycythemia Vera

Summary: jakavi® therapy for polycythemia vera (pv) has so far been studied exclusively in clinical trials and at selected clinical trial centres. this observational study is intended to document the therapy of pv in daily practice with a broad patient population and a geographically representative selection of german centres (both hospitals and practices). the prospective mapping of daily practice reality is thus the main goal of this project.

to achieve meaningful results in accordance with the study objective and to obtain long-term data from daily clinical practice in a real-world setting, the observation period under jakavi® therapy is specified as 36 months.

Eligibility criteria:
inclusion criteria: * adult male and female patients with pv for whom jakavi® therapy is indicated according to the european summary of product characteristics * patients who have been informed about this nis and gave written consent

Keywords: ruxolitinib polycythemia vera pv jakavi
noninvasive dual-mode stimulation therapy for neurorehabilitation in mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: repetitive transcranial magnetic stimulation (rtms) or transcranial direct current stimulation (tdcs) has been used for the modulation of mild cognitive impairment (mci) patients' cognitive function by altering the cortical excitability. recently, more challenging approaches, such as stimulation of two or more sites or use of dual modality have been studied in mci patients. in this study, simultaneous stimulation using both facilitatory rtms (10hz) and anodal or cathodal tdcs (dual-mode stimulation) over bilateral dorsolateral prefrontal cortices (dlpfcs) was investigated to compare its modulatory effects with single facilitatory rtms stimulation in mild cognitive impairment patients.


Eligibility criteria:
inclusion criteria: * patients with mild cognitive impairment diagnosed via a history, a neurocognitive test, and brain imaging exclusion criteria: * k-mmse score under 9 * major active neurological disease or psychiatric disease * a history of seizure * metallic implants in their brain

Keywords: noninvasive brain stimulation repetitive transcranial magnetic stimulation transcranial direct current stimulation
single-blind rct comparing smartphone vs. paper-based hep in pelvic floor pt

Conditions: Pelvic Floor Muscle Weakness

Summary: the goal of this randomized clinical trial is to investigate the impact of a smartphone-based application on patient-reported outcomes for patients with pelvic floor muscle weakness, and the relationship of patient adherence to outcomes in pelvic floor physical therapy compared to the paper-based standard of care. an additional aim is the exploration and development of two patient-reported questionnaires to enhance understanding of exercise adherence in outpatient pelvic floor physical therapy and smartphone application self-efficacy. these goals will serve to improve practice recommendations for home exercise prescriptions in this patient population. participants will be asked to complete 6 patient-reported outcome measures after they complete four, 60-minute long physical therapy treatment sessions conducted one time per week according to the current standard of care for pelvic floor physical therapy. the experimental group will be given a free pelvic floor muscle exercise application while the control group will be provided with the paper-based standard of care for their home exercise program.


Eligibility criteria:
inclusion criteria: * 18-85 years old * referred to outpatient pelvic floor physical therapy for treatment of pelvic floor weakness * generation 5 or later iphone, android, or smart device * must be willing to receive push notification reminders from the application * must have free space on device to download and install app * must have access to the google play store or to ios apple app store exclusion criteria: * ● not meeting inclusion criteria * pelvic organ prolapse surgery with complications * neurodegenerative disease * history of tbi or cva with resulting impairment in long- or short-term memory * denervation injury to the pelvic floor * spinal cord injury * pelvic pain condition * incapable of completing outcomes questionnaire without caregiver support * unable to speak and read english * current pregnancy * less than 6 weeks postpartum * researcher judgement

Keywords: smartphone applications home exercise program adherence