Kornimate/medical-research-clean huggingface dataset:
r-bl-m-04 versus r-(da)-epoch and autologous stem cells transplantation in patients with high-grade b-cell lymphoma double-hit (hgbl dh) and high-grade b-cell lymphoma not otherwise specified (hgbl nos)

Conditions: Lymphoma, High-Grade

Summary: purpose: to evaluate an efficacy of chemotherapy regimens r-da-epoch-21 and r-bl-04 with and without autologous hematopoietic stem cells transplantation (auto-sct) in newly diagnosed patients with high-grade b-cell lymphoma double-hit and high-grade b-cell lymphoma not otherwise specified.

patients initially are randomized into 4 arms: the first arm r-da-epoch-21 the second arm r-bl-m-04 the third arm r-da-epoch-21 + auto-sct the fourth arm of r-bl-m-04 + auto-sct patients who achieved complete remission after 6 cycles of r-da-epoch-21 or 4 cycles of r-bl-m-04 immunochemotherapy continue to be under observation (1st and 2nd arms) or continue treatment with rituximab + bcnu+etoposid+ara-c+melphalan (r-beam) followed by auto-sct (3rd and 4th arms). patients who did not achieve complete remission with pet-ct data (4-5 deauville points) are removed from the protocol and undergoing second-line therapy.

Eligibility criteria:
inclusion criteria: 1. first established the diagnosis of hgbl dh or hgbl-nos. 2. no previous treatment with chemotherapy and/or radiation therapy of dlbcl 3. informed consent of the patient. exclusion criteria: 1. pretreated lymphoma. 2. hiv-associated lymphoma 3. congestive heart failure, unstable angina, severe cardiac arrhythmias and conduction disturbances, myocardial infarction. 4. renal insufficiency (serum creatinine greater than 0.2 mmol/l) (except cases with specific kidney infiltration, urinary tract compression by tumour conglomerate or presence of uric acid nephropathy due to massive cytolysis syndrome). 5. liver failure (except cases with liver tumour infiltration), acute hepatitis or active phase of chronic hepatitis b or c with serum bilirubin greater than 1.5 standards, alanine aminotransferase (alt) and aspartate aminotransferase (ast) greater than 3 standards, prothrombin index less than 70%. 6. severe pneumonia (except cases with specific lungs infiltration), accompanied by respiratory failure (dyspnea \> 30 in min., hypoxemia less than 70 mm hg, when it is impossible to compensate situation in 2-3 days). 7. life-threatening bleeding (gastrointestinal, intracranial), with exception of bleeding due to tumour infiltration of organs (stomach, intestines, uterus, etc.) and disseminated intravascular coagulation due to underlying disease complications after their successful conservative treatment. 8. severe mental disorders (delusions, severe depressive syndrome and other manifestations of productive symptoms) not related to specific infiltration of a central nervous system. 9. decompensated diabetes. 11. pregnancy.
radicle rest: a study of cannabinoids on sleep and health outcomes

Conditions: Sleep; Sleep Disturbance; Sleep Disorder

Summary: a randomized, blinded, placebo-controlled, direct-to-consumer study assessing the impact of plant derived cannabinoids on sleep and overall health outcomes

this is a randomized, blinded, placebo-controlled study conducted with up to 300 adult participants per study arm, age 21 and older and residing in the united states. eligible participants will (1) endorse a desire for better sleep, (2) indicate a willingness to refrain from taking cannabinoids during the study period, and (3) express acceptance in taking a product and not knowing its formulation until the end of the study. participants with known liver disease, heavy drinkers, and those who are pregnant, trying to become pregnant, or breastfeeding will be excluded. those taking medications that warn against grapefruit consumption will be excluded. self-reported data are collected electronically from eligible participants over 5 weeks. participant reports of health indicators will be collected during baseline, throughout the active period of study product use, and in a final survey. all study assessments will be electronic; there are no in-person visits or assessments for this real-world evidence study.

Eligibility criteria:
inclusion criteria: * 21 years of age and older * resides in the united states * endorses a desire for better sleep * selects sleep as a primary reason for taking a cannabinoid product * expresses a willingness to refrain from taking any non-study cannabinoid product (i.e. cbd, cbg, cbc, cbn, thc) for the duration of participant engagement (5 weeks) * expresses an interest in taking a study product and not knowing the product identity until the end of the study exclusion criteria: * pregnant, trying to become pregnant, or breastfeeding * reports a diagnosis of liver disease * reports being a heavy drinker (defined as drinking 3 or more alcoholic beverages per day) * unable to read and understand english * lack of reliable daily access to the internet * reports taking any medication that warns against grapefruit consumption
hpi in older patients undergoing major gastrointestinal surgery

Conditions: the Severity and Duration of Intraoperative Hypotension

Summary: the incidence of intraoperative hypotension was 91%. the increasing incidence of intraoperative hypotension would increase the risk of postoperative complications, such as postoperative arrythmia, stroke or acute kidney injury. major gastrointestinal surgery is a major surgery. older patients usually have many comorbidity, such as hypertension or cardiovascular disease. prevention intraoperative hypotension is an important issue. hypotension prediction index (hpi) could give the clinician pre-alarm of hypotension (mean arterial pressure (map)\<65mmhg). in this study, we aimed to investigate whether hpi could prevent the intraoperative hypotension happened in patients receive elective major gastrointestinal surgery with older than 65 years old.

background: the incidence of intraoperative hypotension was 91%. the increasing incidence of intraoperative hypotension would increase the risk of postoperative complications, such as postoperative arrythmia, stroke or acute kidney injury. major gastrointestinal surgery is a major surgery. older patients usually have many comorbidity, such as hypertension or cardiovascular disease. prevention intraoperative hypotension is an important issue. hypotension prediction index (hpi) could give the clinician pre-alarm of hypotension (mean arterial pressure (map)\<65mmhg). objectives: to investigate whether hpi could prevent the intraoperative hypotension happened. patients and methods: the patients receive elective major gastrointestinal surgery with older than 65 years old. these patients have divided into two groups, including with/without hpi guided. the intraoperative hypotension incidence has been measured. expected result: the hpi would significantly decrease the intraoperative hypotension incidence.

Eligibility criteria:
inclusion criteria: * the age of patients\>=65 years old * patients receivedd major gastrointestinal surgery exclusion criteria: * patients with major organ dysfunction, such as severe arrythmia, heart failure, under hemodialysis
role of colonic events on metabolism and appetite control: a synbiotic approach

Conditions: Obesity; Metabolic Syndrome

Summary: the purpose of the study is to evaluate food factors related to colonically derived regulation of glucose metabolism (and related parameters) and satiety using a semi-acute meal study in healthy subjects as experimental model.


Eligibility criteria:
inclusion criteria: * normal fasting blood glucose, bmi 19-25 kg/m2, for women: hormon based contraceptives exclusion criteria: * gastrointestinal diseases or food allergies e.g. lactose-, gluten intolerance, metabolic disorders e.g. diabetes, tobacco/snuff users. antibiotic or probiotic usage within two weeks, and during the study. vegetarians
the knowledge levels and attitudes of the people living in nevşehir on organ donation and transplantation

Conditions: Organ Finding

Summary: in this descriptive study, the purpose was to determine the knowledge levels and attitudes of the people in nevsehir, turkey on organ donation. it has been determined that the people living in nevsehir do not have sufficient knowledge on organ donation, they had various concerns on the issue, and they wanted to receive information from organ donation units. it can be used the exemplification and internalization in educational curricula about increasing the organ donation.

purpose in this descriptive study,the purpose was to determine the knowledge levels and attitudes of the people in nevsehir on organ donation. methods the data of the study were collected with the questionnaire applied to 414 people residing in nevşehir between february and may 2016. in evaluating the data, the numbers, percentage calculations, chi-square test,t-test, and one-way tests were used.

Eligibility criteria:
inclusion criteria: * anyone aged between 20-65 * the people living in the city center of nevşehir, turkey exclusion criteria: * \<20 years old * 65 years old * the people who do not live the city center of nevşehir, turkey

Keywords: organ donation brain death public opinion
diagnostic efficacy of ffoct imaging for tissue sample obtained by eusfnb

Conditions: Pancreatic Diseases

Summary: in most asian medical centers, rapid on-site cytology evaluation is not available, the number of needle passes of eus-fna is decided by endoscopists. full-field optical coherence tomography (ff-oct) is a new optical imaging technique that could generate sectioning tomogram from fresh tissue and provide close-to-pathology depiction of the morphological structure and pathological changes in minutes without conventional tissue preparation, slicing, and staining, and dynamic cell imaging (dci) added the viability information of cells/tissue, which could be more important in sample rapid evaluation.

light-ct, a special-designed pathology-approximation system which is based on the lighting feature or dynamic feature of tissue and cells, is used to detect malignant cells or tissue in fresh specimens. morphological structure and pathological changes could be captured in minutes, which implies a possible application in intraoperative diagnosis. the investigators aimed to evaluate the diagnostic efficacy of ffoct for the tissue samples obtained from eus-fnb of pancreas.

Eligibility criteria:
inclusion criteria: * tissue samples can be obtained via eus-fnb * signed informed consent letter exclusion criteria: * unable or refuse to provide informed consent
one year clinical evaluation of milled biohpp polyetheretherketone (peek)-based versus metal ceramic single crowns

Conditions: Single Posterior Crowns; Badly Decayed Teeth, Teeth Restored With Large Filling Restorations or Endodontically Treated Teeth; Malformed Teeth, Malposed Teeth (Tilted, Over-erupted, Rotated, Etc.) or Spacing Between Posterior Teeth

Summary: although the metal-ceramic system is still widely used to fabricate crowns and fixed partial dentures and is considered as the standard treatment in dentistry, aesthetic concerns have stimulated the development of new dental tooth-colored systems as peek. biohpp peek is 20% ceramic reinforced, semicrystalline, thermoplastic and radiolucent polymer for extreme durability especially for frameworks for fixed and removable dental prostheses. it has many advantages as low density, light weight, shock absorber, biocompatible and venerable with composite resin. the aim of this study is to evaluate the clinical performance of milled biohpp peek-based single crowns and compare them to metal-based single crowns.


Eligibility criteria:
inclusion criteria: 1. from 18-50 years old, be able to read and sign the informed consent document. 2. have no active periodontal or pulpal diseases, have teeth with good restorations 3. psychologically and physically able to withstand conventional dental procedures 4. patients with teeth problems indicated for single posterior crowns: 1. badly decayed teeth 2. teeth restored with large filling restorations 3. endodontically treated teeth 4. malformed teeth 5. malposed teeth (tilted, over-erupted, rotated, etc.) 6. spacing between posterior teeth 5. able to return for follow-up examinations and evaluation exclusion criteria: 1. patient less than 18 or more than 50 years 2. patient with active resistant periodontal diseases 3. patients with poor oral hygiene and uncooperative patients 4. pregnant women 5. patients in the growth stage with partially erupted teeth 6. psychiatric problems or unrealistic expectations 7. lack of opposing dentition in the area of interest
procurement of follicular b cell lymphoma cells for the purpose of possible use in future clinical trials

Conditions: Non-Hodgkin's Lymphoma

Summary: in order to learn more about follicular lymphoma and anti-cancer vaccines, we are collecting samples from people with this diagnosis. we then hope to make a vaccine from this tissue to help the immune system destroy cancer cells. we plan on keeping samples in the tissue bank indefinitely.

- the following tests and procedures will be performed: approximately 50cc of peripheral blood will be drawn and stored in the tissue bank; patients who have follicular lymphoma cells circulating in the blood will have about 40cc's of blood drawn and stored for processing; patients undergoing a lymph node biopsy will have samples of the biopsy stored; patients having fluid drained from the abdomen or from around the lung will have some of their fluid saved to cell collection and processing; patients undergoing a bone marrow biopsy will have some of the sample stored for cell collection and processing.

Eligibility criteria:
inclusion criteria: * relapsed, refractory or de novo histologically confirmed follicular b-cell lymphoma with accessible lymph nodes, tumor mass or malignant effusion or peripheral blood * 35 years of age or older exclusion criteria: * uncontrolled active infection * hiv or viral hepatitis infection * other current malignancies except any in situ cancer or basal or squamous cell carcinoma of the skin * autoimmune cytopenias

Keywords: follicular b cell lymphoma vaccination
clinical study of frc implant to treat skull bone defects

Conditions: Cranial Bone Defect; Orbital Base Fracture

Summary: bioactive fibre-reinforced composite implant is used for reconstruction of skull bone defects and orbital floor defects. functional and aesthetic outcome is assessed by patient and doctor.

development phase: clinical trial objectives: assessment of functional and aesthetic outcome methodology: intervention study sample size: 35+20+25 main criteria for inclusion: skull bone defect or orbital floor fracture investigational drug/treatment, dose and mode of administration: frc implant comparative drug(s)/placebo/treatment, dose and mode of administration: - duration of treatment: 2 years of follow-up assessments: clinical outcome and radiologic assesment functional and aesthetic outcome with visual analog scale (vas). pain assessment with vas. statistical methods: adequate statistical methods for publishing in international peer-reviewed journals.

Eligibility criteria:
inclusion criteria: study arm 1: * patients with skull bone defect * reconstruction indications fullfilled study arm 2: * patients with orbital floor defect * reconstruction indication fullfilled exclusion criteria: * if informed consent cannot be obtained

Keywords: craniofacial bone reconstruction fibre-reinforced composite bioactive glass craniotomy skull bone defect
soluble corn fiber supplementation for asthma

Conditions: Asthma in Children

Summary: studies of the importance of the human microbiome have demonstrated that microbial metabolites of fermentation of our dietary products (e.g. dietary fiber) have a multitude of health benefits. the investigators aim to determine whether supplementation of asthmatic children with soluble corn fiber alongside standard of care reduces airway inflammation driven by the gut microbial metabolites acetate, propionate, or butyrate (short chain fatty acids).

asthma is a complex inflammatory disease of the airways that is estimated to affect 300 million people worldwide. incidence of asthma is steadily increasing in western populations; an additional 100 million asthma diagnoses are anticipated by the year 2025. asthma is a multifactorial disease affected by genetic and environmental factors. one major and potentially modifiable environmental factor is the western diet. the western diet influences the microbiome, which in turn, may influence inflammatory airway diseases via a gut microbiome-airway connection. the investigators hypothesize that prebiotic dietary fiber supplementation leads to increased circulating short chain fatty acid production and improvement in asthma disease activity. the investigators will recruit 20 children, ages 6-17 years old, with asthma from the severe asthma clinic or general pulmonary clinic at phoenix children's hospital. participants will be randomly assigned (1:1) using a random number generator to ingest promotir soluble corn fiber (85% fiber, 12 g/day) in a fruit-flavored beverage or placebo (malodextrin in a similar fruit-flavored beverage) as previously described. participants will be asked to consume the prebiotic soluble corn fiber (or placebo) for 4 weeks alongside their normal diet and normal asthma treatments. blood will be collected pre- and post-fiber intervention to measure baseline and post-intervention circulating scfas. stool samples and nasal wash will be collected for microbiome and immune analysis pre- and post- fiber consumption. nasal washes will be collected pre- and post-fiber consumption to measure inflammatory patterns.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of asthma * fractional excretion of exhaled nitric oxide (feno) \> 50 ppb or a history of environmental allergies * no emergency department or hospital visits for asthma in the past 3 months * no systemic corticosteroids in the past 1 month * ability to consume a liquid drink of scf or placebo * ability to return for a 4-6 week follow-up visit * no special or unique diet as determined by pi/co-is. exclusion criteria: * cystic fibrosis * bronchiectasis * change in asthma medicines other than short acting bronchodilators planned over the next 4-6 weeks.
hand therapy or not following collagenase treatment for dupuytren's contracture?

Conditions: Dupuytren Disease of Palm and Finger, With Contracture

Summary: this study evaluates if hand therapy have an impact on the patients' preformance of and satisfaction with everyday activities or not following collagenase injection treatment for dupuytren's contracture. differences on this between patients with contracted proximal interphalangeal joint(s) and patients with affected metacarpophalangeal joint(s) only, will also be investigated. two equal sized groups will either receive hand therapy or no treatment following the injection and extension procedure.

today it varies if patients with collagenase treated dupuytren's contracture (dc) are referred to hand therapy or not. no studies are found looking at the effect of therapy following collagenase treatment compared to no therapy. the main purpose of the study is to find if hand therapy improves patients' performance of and satisfaction with everyday activities or not, one year after collagenase treatment for dc. differences on this between patients with contracted proximal interphalangeal joint(s) (pipj) and patients with affected metacarpophalangeal joint(s) (mcpj) only, will also be investigated. a norwegian randomised controlled trial will be conducted with two parallel intervention groups in a pre-test - post-test design. hand therapy includes oedema control, scar management, night-time splinting, movement exercises and use of everyday activities as therapy. additional individualised therapy will be provided if needed. test times are right before, straight after, six weeks, four months and one year after collagenase treatment. sample size needed is 160 participants. appropriate methods of statistical analysis will be used. discussion research on dc is challenging as the clinical picture is heterogeneous, no cure exists and no agreement on who should receive collagenase treatment. hand therapy in the study will be individualised and not equal for every patient.

Eligibility criteria:
inclusion criteria: * patients treated with collagenase injection and extension procedure for dupuytren's contracture exclusion criteria: * earlier injury or treatment for dupuytren's contracture in the same finger * patients not capable of following a therapy program * before randomisation: infection or an allergic reaction to the drug or complex regional pain syndrome arising * earlier participation in the same study makes the participant not eligible to be included once more when treated in the other hand.

Keywords: occupational therapy physical therapy hand therapy adl copm uram rom hand exercise scar oedema splint orthosis
study to compare the overall survival of patients receiving ingn 201 (study drug) with patients receiving methotrexate

Conditions: Carcinoma, Squamous Cell

Summary: there is a need for more treatment options for patients with recurrent squamous cell cancer of the head and neck (scchn). these tumors usually have a variety of genetic defects that include disruption of the p53 pathway, a pathway that would ordinarily work to prevent the development of tumors. in this study the transfer of the p53 gene to tumor cells using a modified adenovirus (ingn 201) will be compared to methotrexate in patients who have failed surgery, radiotherapy and chemotherapy with platinum or taxanes.


Eligibility criteria:
* 18 years or older * not eligible for surgery * must have had radiation and chemotherapy treatments * no prior methotrexate treatments

Keywords: refractory squamous cell carcinoma of the head and neck
identification of vulnerability factors in the course of pemphigus patients

Conditions: Pemphigus; Dermatological Disease

Summary: the bullous pemphigoid treatment is based on corticosteroids continued for several years. pemphigus causes some patients a psychological impact and sometimes major vulnerability that can occur not only at diagnosis but also at later stages of disease progression. our hypothesis is that these episodes of vulnerability may be under four kinds of factors that may be connected to the plurality of the history of these patients, and the resources they can mobilize throughout this experience, generating inequality in management and "work" around the disease.

the originality of the project lies in its multidisciplinary approach (dermatology, psychology, sociology). no such study has yet been carried out in the pemphigus who has been the subject of a very small number of works in sociology or psychology. the only studies are studies of quality of life with no longitudinal follow-up. the perspective of qualitative and quantitative data, sociological and psychological approaches, should allow more innovative and adapted to the medico-social and psychological care of patients with pemphigus approaches. the purpose of this study is to identify the determinants leading to moments of vulnerability in the course of patients with pemphigus in order to be able to offer preventive or corrective actions to improve the experience of the disease.

Eligibility criteria:
inclusion criteria: * patient major * patients with pemphigus vulgaris, diagnosed on a combination of: 1. clinical signs and 2. histological image above basal epithelial detachment with intra acantholysis, 3. direct immunofluorescence showing deposition of immunoglobulin g and / or c3 to the surface of keratinocytes * join a social security scheme * patient has been informed and have signed consent to participate in the study exclusion criteria: * person placed under judicial protection, * patient without liberty by administrative or judicial decision, * patient participating in another trial for the duration of monitoring.

Keywords: psychological support therapeutic education vulnerability of patients