Kornimate/medical-research-clean huggingface dataset:
effect of the enteric hormone glucagon-like peptide (glp-2) on the intestinal blood flow in patients with short bowel syndrome

Conditions: Short Bowel Syndrome

Summary: the aim of the study is to investigate the effect of the enteric hormone glucagon-like peptide (glp-2) on patients with short bowel syndrome

previous studies have shown that glp-2 increases mesenteric blow flow, we wish to examine the effect of subcutaneus glp-2 on patients with short bowl syndrome. the patients will single blinded been given 450 nmol glp-2 and isotonic saline in order to act as their own reference.

Eligibility criteria:
inclusion criteria: * clinical diagnose of short bowel syndrome 4 month of stable fase exclusion criteria: * activity in ibd

Keywords: mesenteric blood flow glp-2 short bowel syndrome glucagon-like peptide 2
carotid artery corrected flow time as a predictor of hypotension after induction of general anesthesia in elderly patients

Conditions: General Anesthesia Induction for Elective Surgery

Summary: the number of elderly patients undergoing elective surgery has been growing in recent years. elderly patients often have a variety of underlying diseases, including hypertension, coronary heart disease, diabetes, arteriosclerosis, etc., which increase the risk. when the elderly receive general anesthesia, hypotension often occurs after anesthesia induction. once hypotension occurs, it may lead to myocardial ischemia, myocardial infarction, stroke and other serious complications. therefore, in clinical anesthesia, a simple, quick and accurate prediction method is needed to evaluate and predict the risk of hypotension in elderly patients after induction, so that appropriate intervention measures can be taken in advance to reduce the incidence of hypotension in elderly patients after induction, thus reducing the occurrence of related complications and ensuring the safety of anesthesia and surgery.carotid artery corrected flow time（ftc） is a recently developed volumetric predictor, which refers to the time between the the onset of systolic flow until the closure of the aortic valve. it is related to cardiac preload and can reflect cardiac output to a certain extent. it is considered as a reliable indicator for evaluating volume status and volumetric reactivity. therefore, this study assessed the effect of ftc combined with perioperative fluid therapy on preventing hypotension after general anesthesia induction in elderly patients.


Eligibility criteria:
inclusion criteria: * patients who received elective surgery under general anesthesia, aged 65-85 years old, gender unlimited, asai-ii exclusion criteria: * uncontrolled hypertension * unstable angina pectoris * history of myocardial infarction * after heart stent implantation * severe arrhythmia：atrial fibrillation、ventricular premature beat, frequent atrial premature beat, other non-sinus rhythm * pacemaker implants * cardiomyopathy * a left ventricular ejection fraction of \< 40% * history of neck trauma and surgery * bmi\>30
study of psychomotor development and attachment in children aged 6 to 30 months with oral disorder

Conditions: Eating Disorders in Children; Psychomotor Development Impaired

Summary: dietary difficulties and eating disorders of the child are a common reason for consulting infants and young children. there is currently little data on the psychomotor development of these children and their association with parent-child attachment. the objective of this study is to evaluate, at the same time, the three physiological, psychomotor and attachment dimensions of children with eating disorders.


Eligibility criteria:
inclusion criteria: * age: 6 to 30 months * oral disorder defined by a mch score ≥ 61 exclusion criteria: * children in enteral nutrition asked for an indication other than oral disorders * children followed for serious chronic organic pathology causing disorders of the oral (dntc, swallowing disorders, etc.) * child already assessed by the psychomotrician who participated in the study * placement of the child in a medical institution or in a foster family. * parents' refusal to participate in the study * establishment of a psychomotor follow-up between the time of the medical consultation and the psychomotor evaluation.

Keywords: eating disorders in children psychomotor development impaired
use of the peak plasmablade 4.0 in bilateral breast reduction

Conditions: Macromastia (Symptomatic)

Summary: the objective of this clinical study is to evaluate the operative performance of the peak plasmablade® 4.0 during bilateral breast reduction; to monitor and record post-operative pain, adverse events and skin scarring following surgery; and to compare these outcomes to the harmonic synergy® blade.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 70 2. physically healthy, stable weight 3. no smoking \<1 month prior to surgery and during study. 4. desiring bilateral breast reduction 5. subject must understand the nature of the procedure and provide written informed consent prior to the procedure. 6. subject must be willing and able to comply with specified follow-up evaluations. 7. female subjects must either be incapable of reproduction, or taking acceptable measures to prevent pregnancy and have a negative pregnancy test prior to participation in the study. exclusion criteria: 1. age younger than 18 or greater than 70 years old 2. anticoagulation therapy which cannot be discontinued 3. smoking \<1 month prior to surgery or during study 4. infection (local or systemic) 5. cognitive impairment or mental illness 6. severe cardiopulmonary deficiencies 7. known coagulopathy 8. immunocompromised 9. prior history of breast cancer 10. kidney disease (any type) 11. currently taking any medication known to affect healing 12. subjects who are status-post gastric banding or gastric bypass 13. currently enrolled in another investigational device or drug trial 14. unable to follow instructions or complete follow-up

Keywords: reduction mammaplasty breast reduction plasmablade peak
rps inflammadry detector™ to determine mmp-9 levels in tears

Conditions: Dry Eye

Summary: the rps inflammadry detector™ is intended to detect elevated mmp-9 in human tears to aid in the diagnosis of patients with signs or symptoms of dry eye disease, in conjunction with other methods of clinical evaluation.

the purpose of this clinical trial was to determine the sensitivity and specificity of inflammadry compared with the clinical assessment of dry eyes. patients were screened using clinical history and signs. clinical history was performed using the ocular surface disease index (osdi) and evaluated for clinical signs: * positive vital staining of the ocular surface, * decreased tear breakup time (tbut), * reduced corneal sensitivity, and * decreased functional visual acuity last, an independent health care professional masked to the clinical evaluation was asked to analyze each inflammadry test result, independently confirming each result.

Eligibility criteria:
inclusion criteria patients older than 18 years of age, who meet the following criteria related to the clinical history and signs will be enrolled: group 1: clinical dry eyes clinical history criteria an ocular surface disease index (osdi) of greater than or equal to 13 - \[appendix #2\] clinical signs criteria - all of the following must be present 1. schirmer's tear test (with anesthesia) \< 10 mm over 5 minutes 2. tear film break up time (tbut) \< 10 seconds 3. total corneal staining ≥ 1 \[appendix #1\] * at least 1/2 of all patients enrolled will have a schirmer's tear test \< 5 mm or demonstrate corneal staining ≥ 2 \[appendix #1\] group 2: clinical normal non-dry eyes clinical history criteria an ocular surface disease index (osdi) of \< 7 - \[appendix #2\] clinical signs criteria - all 3 of the following must be present 1. schirmer's tear test (with anesthesia) ≥ 10 mm over 5 minutes 2. tear film break up time (tbut) ≥ 10 seconds 3. total corneal staining = 0 \[appendix #1\] exclusion criteria * patients with allergy to corn starch, talcum powder, or dacron * patients with prior eye injury, trauma, or ocular surgery within the previous 3 months * patients with non-dry eye ocular inflammation, uveitis, history of herpetic keratitis or zoster keratitis * patients with history of a recent ocular infection within the prior 1 month * use of oral doxycycline or topical macrolides (azasite) within 1 month * patients currently receiving, or received in the last 2 weeks of the study , certain medications including topical or systemic corticosteroids, topical or systemic nonsteroidal (nsaids) therapy, topical cyclosporine, or other immunosuppressive therapy * patients who are pregnant or lactating * before initialization of the study, patients must not have used any topical medications, including artificial tears during the previous 2 hours * the use of rigid-gas permeable contact lenses or the use of soft-contact lenses within 1 month of the study

Keywords: dry eyes dysfunctional tear syndrome
the current study aimed to evaluate the therapeutic features and complications of liver hydatid cyst in patients who underwent surgery for ce in fars province, southern iran.

Conditions: Patients Who Underwent Surgury for Hydatid Cyst

Summary: the current study aimed to evaluate the therapeutic features and complications of liver hydatid cyst in patients who underwent surgery for ce in fars province, southern iran. a total of 293 patients who underwent surgery for liver hydatid cyst from 2004 to 2018 in fars province, southern iran, were retrospectively evaluated. the clinical records of patients were reviewed and the demographic and clinical characteristics of each patient were assessed.

fars province with the capital of shiraz in one of the thirty-one provinces of iran located in the southwest part of the country with a population of more than 4.6 million people of which 67.6% living in urban areas, 32.2% in rural areas and 0.3% live as nomad tribes. the average temperature of fars province is 17.8 °c, ranging between 4.7 °c and 29.2 °c and the annual rainfall is 261mm. animal farming and agriculture are of great importance as they are considered as two main economic bases of this province. this type of livelihood has facilitated the presence of some of the zoonotic diseases such as ce and toxocariasis and leishmaniasis. data collection hospital records of a total of 293 patients who underwent surgery for liver hydatid cyst from 2004 to 2018 in two major university-affiliated hospitals in fars province, southern iran, were retrospectively evaluated. in all cases, the preliminary diagnosis of hydatid cyst has been confirmed by postoperative pathological findings. so, the inclusion criterion of operation with the diagnosis of ce was considered while reviewing the records. information such as age, sex, presenting signs and symptoms of hydatid cyst, number and the specific location of cystic structures, history of relapse, reoperation, characteristics of the cyst (calcification, puss discharge, multicystic, multiloculated, daughter cyst, rupture, inflammation, superimposed infection, and septation), early postoperative complications, diagnostic procedures such as ultrasound scanning, computed tomography, x-rays, pathology reports, lab data, operation information and, drug therapy were extracted from the hospital records of each patient. the surgical procedure used for the patients, radical or conservative, was noted.

Eligibility criteria:
inclusion criteria: having a surgery due to hydatid cyst exclusion criteria: surgeries other than hydatid cyst. -

Keywords: hydatid cyst, surgery, hospital record
comparison of retinal nerve fiber layer (rnfl) thickness measurements by time-domain and spectral-domain oct in glaucoma patients

Conditions: Primary Open Angle Glaucoma

Summary: measurement of rnfl thickness by oct is at a cornerstone for the correct diagnosis and monitoring of progression of glaucomatous optic neuropathy. spectral domain technology has enabled better reproducibility with better axial resolution in the measurement of rnfl thickness. a comparative study among stratus, cirrus and rt-view will enable clinicians to determine differences among various instruments.


Eligibility criteria:
exclusion criteria: * evidence of retinal disease * secondary glaucoma due to intraocular inflammation * lens induced glaucoma * neovascular glaucoma * tumor induced glaucoma

Keywords: rnfl thickness
radio-opaque contrast agents for liver cancer targeting with kim during radiation therapy

Conditions: Liver Neoplasm

Summary: this observational study will investigate the properties of image files standardly collected during radiation therapy treatment in a cross-section of liver cancer patients who received stereotactic ablative body radiation therapy (sabr) after trans-catheter arterial chemo emobilisation (tace). specifically, it will determine whether the radio-opaque contrast agents in the image files can be detected by tumour-tracking software (kim).

* sites will collect image files from the cancer radiation therapy systems and the medical records of eligible participants. for patient who do not have implanted markers, research personnel (a radiation oncologist, medical physicist or radiation therapist) will manually outline the visible contrast mass. this outline is considered the 'ground truth' of the location of the contrast mass. to ensure its accuracy, the ground truth contrast mass location will be checked by research personnel from another study site. * image and ground truth data collected from 80% of participants will be used by university of sydney researchers to develop the kim algorithm to detect and track the radio-opaque contrast agents with sufficient robustness to provide justification for the prospective use of kim as a real-time image guided radiation therapy tool for liver cancer patients. * the developed kim software will be applied by site medical physicist(s) to the treatment imaging data from the remaining 20% of participants the images. tumour positions produced by kim will be compared with a 'ground truth' manual delineation.

Eligibility criteria:
inclusion criteria: * received or will receive stereotactic ablative body radiotherapy (sabr) treatment for liver cancer at a participating site. * received a radio-opaque contrast agent (e.g. lipiodol™ or dc bead lumi™) that is visible on the radiation treatment planning ct scan * the radio-opaque contrast agent mass is or will be within the x-ray imaging field of view during the cbct scan and any planned intra-fraction imaging. note that there is no requirement of the distance between the contrast agent mass and the treated tumour as the goal of the study is the contrast agent mass tracking. * provides written informed consent (prospectively recruited) or meets criteria for waiving of the requirement for consent (retrospectively recruited) exclusion criteria: * less than 18 years of age * minimum image dataset is not available * image dataset is not in a compatible format

Keywords: radiation therapy stereotactic ablative body radiation therapy sabr kilovoltage intrafraction monitoring radio opaque contrast
resveratrol supplementation in patients with mitochondrial myopathies and skeletal muscle fatty acid oxidation disorders

Conditions: Mitochondrial Myopathies; Fatty Acid Oxidation Defects

Summary: the purpose of this study is to investigate the potential beneficial effects of a daily supplement of resveratrol (1000mg/day) on physical ability and on muscle metabolism in patients with verified mitochondrial myopathy and patients with a verified fatty acid oxidation defect of vlcad and cptii deficiencies. investigators hypothesize an improved muscle metabolism, mitochondrial function, fatty acid oxidation and thus improvement of physical ability.

study design: double-blind, randomized, placebo-controlled, cross-over study. to ensure enough participants, and due to the risk of a heterogeneous cohort, a cross-over design is chosen, where participants are their own controls. 10 patients with mitochondrial myopathy and 10 patients with fatty acid oxidation defects will be included. eligible patients will be randomized using a 1:1 assignment ratio to receive placebo or rsv first. each treatment will be administered orally twice daily for 8 weeks, followed by a 4 weeks wash-out, and afterwards a new 8-week treatment period. during the 20-week trial period, subjects will visit the trial site on five occasions, for functional assessments (cycle ergometer testing), blood sampling and questionnaires.

Eligibility criteria:
inclusion criteria: 1. patient is willing and able to provide written informed consent prior to participation. 2. patient is ≥18 and ≤80 years of age at baseline. 3. patients have genetically verified mitochondrial disorder or a fatty acid oxidation deficiency (vlcad/cptii). 4. patient has a clinical presentation, signs or symptoms suggestive of myopathy (e.g., easy fatigability, exercise intolerance, muscle pain) in the opinion of the investigator. 5. patient is ambulatory. exclusion criteria: 1. patient has any prior or current medical conditions that, in the judgment of the investigator, would prevent the patient from safely participating in and/or completing all study requirements. 2. patient has symptoms of mitochondrial myopathy due to known secondary mitochondrial dysfunction (e.g., drug-induced myopathy). 3. patient does not have the cognitive capacity to understand/comprehend and complete all study assessments. 4. pregnancy or breastfeeding
effects of therapeutic touch in patients with female genital neoplasia: a randomized controlled clinical trial

Conditions: Quality of Life; Gynecologic Neoplasm; Gynecologic Cancer; Palliative Care; Therapeutic Touch; Reiki

Summary: this is a randomized controlled prospective study on the use of therapeutic touch in patients diagnosed with gynecological cancer. the patients will be randomized into three groups: control group (will not receive any interventions with therapeutic touch), placebo group (will receive simulated therapeutic touch intervention by individual not knowing this technique) and treatment group(will receive therapeutic touch intervention by a trained therapeutic touch therapist). two different quality of life questionnaires will be applied (before and after treatment). levels of cortisol, salivary iga, hematological indices and telomerase activity before and after the use of therapeutic touch will be compared between groups.

this project is a randomized controlled prospective study on the use of therapeutic touch in patients diagnosed with gynecological cancer. the patients will be randomized into three groups: control group (will not receive any interventions with therapeutic touch), placebo group (will receive simulated therapeutic touch intervention by individual not knowing the practice) and treatment group (will receive therapeutic touch intervention by a trained therapeutic touch therapist). two different quality of life questionnaires (world health organization quality of life questionnaire - whoqol-bref and the quality of life core-30 questionnaire - eortc qlq-c30) from the european organization for research and treatment of cancer will be applied before and after treatment. levels of cortisol, salivary iga, hematological indices and telomerase activity before and after the use of therapeutic touch will be compared between groups.

Eligibility criteria:
inclusion criteria: * female patients * age over 18 years * diagnosis of neoplasms of the female genitalia * signature of the consent form exclusion criteria: * history of previous contact with the therapeutic touch technique * use of psychotropic drugs, severe neurological or psychiatric disorders that make it impossible to participate in the study.

Keywords: therapeutic touch reiki laying-on-of-hands spiritual therapies
study of vitamin d for the prevention of acute respiratory infections in children

Conditions: Acute Respiratory Tract Infections

Summary: the main purpose of this study is to determine whether weekly oral vitamin d supplementation is effective to prevent acute respiratory tract infections in children. the hypothesis of the study is that vitamin d supplementation reduces the incidence and severity of acute respiratory tract infections in children.

acute respiratory tract infections (artis) are associated with high levels of morbidity and socioeconomic impact, particularly affecting young children. observational studies have shown an association between vitamin d (vd) deficiency and higher incidence and severity of respiratory infections. chile has a high prevalence of vd deficiency, particularly in the southern regions of the country. the objective of this study is to evaluate the safety and efficacy of oral vd supplementation to decrease the incidence of artis in 275 preschool children. a randomized, placebo-controlled, double-blind study will be performed in santiago, coyhaique and punta arenas. children aged 18 to 36 months will be given weekly oral 5600 iu of vitamin d3 (vd3), 11200 iu of vd3, or placebo doses during 6 months.

Eligibility criteria:
inclusion criteria: * children aged 18 to 36 months attending daycare in santiago, coyhaique or punta arenas. exclusion criteria: * history of chronic illness requiring immunosuppression * history of metabolic bone disease * use of vitamin d supplementation greater than 400 iu daily, either by milk formula or vitamin supplements in the last 3 months. * use of fish oil supplements in the last 3 months. * immunodeficiency * planned trip to sunny climate during study period.

Keywords: acute respiratory tract infections vitamin d cholecalciferol children bronchiolitis pneumonia prevention
high-definition transcranial direct current stimulation for facilitating hand function recovery after stroke

Conditions: Stroke

Summary: transcranial direct current stimulation (tdcs) had recently been shown having feasibility in modulating cortical excitability transiently during motor training in a noninvasive way. the findings support that tdcs and motor practice can positively promote post-stroke motor learning to improve upper-limb motor recovery after stroke. a randomized controlled trial will be conducted with three groups: hd-tdcs, conventional tdcs and sham hd-tdcs. a 10-session training will be provided to evaluate the effectiveness of transient modulation of cortical excitability through tdcs with clinical assessment scores.


Eligibility criteria:
inclusion criteria: 1. hemiparesis subsequent to first-ever unilateral stroke for more than 6 months; 2. mcp and pip finger joints can be extended to 180° passively; 3. sufficient cognition to follow the experimental instructions exclusion criteria: 1. severe hand spasticity or hand deformity; 2. history of alcohol or drug abuse or epilepsy; 3. bilateral brain infarcts; 4. severe cognitive deficits; 5. comprehensive aphasia; 6. contraindications to tdcs