Kornimate/medical-research-clean huggingface dataset:
efficacy and safety prediction of milrinone or levosimendan as initial inotropic drug therapy in patients with acute and advanced heart failure with renal insufficiency

Conditions: Heart Failure; Levosimendan; Milrinone; Efficacy; Safety

Summary: 1. to evaluate the efficacy and safety of levosimendan and milrinone in the treatment of with acute heart failure with or without renal dysfunction; 2. predictive modeling of the efficacy and safety of levosimendan and milrinone.

by comparing the safety and efficacy of milrinone with levosimendan as an initial inotropic agent for the treatment of patients with acute heart failure with or without abnormal renal function, a preliminary efficacy and safety prediction model was developed for levosimendan and milrinone based on the basic characteristics of the patients and the level of renal function.

Eligibility criteria:
inclusion criteria: * 18-80 years old * patients who were clearly diagnosed with heart failure ( cardiac insufficiency ) and lvef(left ventricular ejection fraction) \< 50 %, and were judged by the physician to need and agree to use levosimendan or milrinone to maintain hemodynamic stability exclusion criteria: * chronic heart failure and new york heart association ( nyha ) class i \~ ii * complicated with infective endocarditis, aortic dissection, severe liver dysfunction ( child-pugh c ), severe renal insufficiency ( crcl \< 30 ml / min ), hypertrophic obstructive cardiomyopathy, ventricular assist device or surgical cardiac surgery within 30 days before the use of levosimendan * patients with severe ventricular arrhythmia 1 within 24 hours before levosimendan and systolic blood pressure 100 times / min within 2 hours before levosimendan * during hospitalization, other positive inotropic drugs 2 were used when levosimendan was intravenously pumped or dripped, excluding the use of catecholamines for rescue * received positive inotropic drug 2 treatment in the last 30 days * lack of serum creatinine, brain natriuretic peptide or brain natriuretic peptide precursor, serum total bilirubin, cardiac ultrasound baseline ( within 14 days before using levosimendan ) data * pregnant and lactating women

Keywords: acute and advanced heart failure milrinone levosimendan renal insufficiency
non-responders to antiplatelet treatment in acute ischaemic stroke)

Conditions: Acute Ischemic Stroke

Summary: determination of frequency of clopidigrel- and acetacylicacid-non-responders (hotpr) in acute ischemic stroke patients.

determination of frequency of clopidigrel- and acetacylicacid-non-responders (hotpr) in acute ischemic stroke patients using the verifynow system.

Eligibility criteria:
inclusion criteria: * suspected acute ischemic stroke and loading dose of clopidogrel or acetacylicacid exclusion criteria: * previous treatment with platelet inhibitor * noac or vitamin k-antagonist treatment * final diagnosis other than ischemoc stroke or transitoric ischemic attack

Keywords: clopidogrel acetacylic acid antiplatelet therapy hotpr verifynow
combination of icotinib and gemcitabine as first-line treatment in pancreatic cancer

Conditions: Pancreatic Cancer

Summary: research hypothesis: icotinib administered in combination with gemcitabine has an acceptable safety profile in subjects with locally advanced, unresectable or metastatic pancreatic adenocarcinoma.the primary objective is to determine the safety profile of icotinib in combination with gemcitabine in subjects with locally advanced, unresectable or metastatic pancreatic adenocarcinoma.


Eligibility criteria:
inclusion criteria: * locally advanced, unresectable or metastatic pancreatic cancer by histologic or cytologic confirmation without previous chemotherapy or target therapy. * ecog performance status of 0 to 1. * adequate organ function as defined by study-specified laboratory tests. * signed informed consent form. * willing and able to comply with study procedures. exclusion criteria: * previous chemotherapy or target therapy. * currently have or have history of certain study-specified heart, liver, kidney, lung, neurological, immune or other medical conditions. * systemically active steroids. * another investigational product within 28 days prior to receiving study drug. * major surgery or significant traumatic injury (or unhealed surgical wounds) occurring within 28 days prior to receiving study drug. * infection with hiv, hepatitis b or c at screening. * pregnant or lactating. * conditions, including alcohol or drug dependence, or intercurrent illness that would affect the patient's ability to comply with study visits and procedures.
pilot data collection for activity, adiposity, and appetite in adolescents

Conditions: Physical Activity; Sedentary Lifestyle; Metabolism; Energy Balance

Summary: the goal of this study is to quantify energy metabolism using indirect calorimetry at rest, in the presence of excess energy following a meal, and in response to the demand for energy during exercise. the investigators also will examine the individual and joint associations of activity and obesity status on neurocognitive domains of appetite control. participants will include adolescent males and females (n=80) using a 2 x 2 cross-sectional study design, stratified by body weight (normal vs overweight/obese) and physical activity level (sedentary vs. active).

the investigators hypothesize that low levels of fitness and mvpa result in impaired metabolic function in adolescents. for this pilot study, the investigators will quantify variations in metabolic characteristics using a 2 x 2 cross-sectional study design, stratified by body weight (normal vs overweight/obese) and physical activity (sedentary vs. active). the goal is to identify metabolic factors that influence the energy balance system to directly inform interventions designed to prevent or reduce the prevalence of pediatric obesity.

Eligibility criteria:
inclusion criteria: * males (tanner stage iii-iv), ages 14-18 * weight stable (5% weight change) over the previous three months as assessed by self-report. * bmi greater than 5th and less than 99th percentile * physically healthy for exercise as assessed by self report physical activity readiness questionnaire (par-q) for children. * for fmri testing, all participants must be right handed and must have normal or corrected to normal vision (as they will be viewing pictures in the fmri procedure). exclusion criteria: * history of restrained eating, eating disorders, bariatric surgery, or other significant medical diagnosis that could impact metabolism. * participants taking thyroid medications, beta blockers, or other stimulants (medications are known to affect physical activity level and metabolism). * due to fmri procedure requirements, children with a history of attention deficit hyperactivity disorder (adhd) or other diagnosed psychiatric issues will be excluded.
clinical evaluation of acupuncture on the complications of cerebral vascular accident

Conditions: Stroke

Summary: the lifestyle of taiwanese people has been changed over the past decade with the improvement of economic growth, environmental sanitation and the quality of medical care. now the investigators pay more attention to the increasing risk of people's diseases of civilization than people's malnutrition and poor quality of environmental sanitation. the cerebrovascular accident (cva) leads to death and bio-psycho-social dysfunction. the medical care of the patient of cerebrovascular accident cause a lot of money and is a burden of our country. our study emphasizes that acupuncture change bio-psycho-social aspects of the patient with cerebrovascular accident. the investigators use some scales to assess efficacy of acupuncture, such as barthel index, national institute of health stroke scale, visual analogue scale, instrumental activities of daily living and hamilton depression rating scale. besides, the investigators notice that there are few journals about acupuncture effect of treating depression following cerebral vascular accident. the investigators may underestimate the amount of people having post-stroke depression. so the investigators use hamilton depression rating scale to assess the post-stroke depression of cerebral vascular accident patient. by assessing bio-psycho-social level of cva patient, the investigators hope this study will offer them more "holistic health care".

we want to assess the effect of acupuncture on stroke patients. the study is a double-blind randomized controlled trial. we need 80 patients altogether. the inclusion criteria: (1)first time stroke(ischemic or hemorrhagic stroke) with paresis or plegia exclusion criteria: (1)transient ischemic attack (2)brain tumor, brain trauma (3)recurrent stroke (4)multiple organs failure, cancer the whole course of the acupuncture contains 24times(about 3 months). the acupoints are fixed and located over head and limbs. the whole course of the sham acupuncture contains 24times(about 3 months). the acupoints are fixed and 1cm away from meridian and no acupoints over head were chosen. the investigators use barthel index, national institute of health stroke scale, hamilton depression rating scale, instrumental activities of daily living scale and visual analogue scale to assess the effect of acupuncture on stroke patients. four times of assessment are as below: baseline, after 8th treatment, after 16th treatment, after 24th treatment (the last time of treatment). the course of treatment should be completed within 3 months.

Eligibility criteria:
inclusion criteria: * first time stroke(ischemic or hemorrhagic stroke) with paresis or plegia exclusion criteria: * transient ischemic attack * brain tumor, brain trauma * recurrent stroke * multiple organs failure, cancer

Keywords: acupuncture stroke randomized controlled trial
neuromodulation of the dorsal genital nerve in persistent genital arousal disorder

Conditions: Arousal Disorders, Sexual

Summary: the goal of this clinical trial is to learn if neuromodulation of the dorsal genital nerve works to treat symptoms related to persistent genital arousal disorder in women. the main questions it aims to answer are: what is the effect of neuromodulation on pgad symptoms in women? participants will: use a neurosimulator every day for 3 weeks. keep a diary of their symptoms and the number of times they used the neurostimulator fill in questionaires


Eligibility criteria:
inclusion criteria: * women with pgad exclusion criteria: * women \< 18 years * women not able to handle the neuromodulator * women in whom the anatomy of the genitals precludes proper electrode placement

Keywords: neuromodulation neurostimulation persistent genital arousal disorder
nasal epap for stroke patients with sleep apnea: a pilot trial.

Conditions: Ischemic Stroke; Obstructive Sleep Apnea

Summary: specific aim: to test the effects of nasal expiratory positive airway pressure (epap) therapy on sleep apnea severity among patients with recent ischemic stroke. hypothesis 1: ischemic stroke patients with sleep apnea will have less severe sleep apnea, as measured by the apnea-hypopnea index (ahi), with nasal epap therapy compared with a control night. hypothesis 2: ischemic stroke patients will have higher mean levels of oxygen saturation with nasal epap therapy compared with a control night.


Eligibility criteria:
inclusion criteria: * adults with an ischemic stroke (including tia with infarction) within the prior 14 days exclusion criteria: 1. current use of any transnasal tube (eg dobhoff tube) 2. current use of cpap, mechanical ventilation, or supplemental oxygen 3. known severe breathing disorders including hypercapnic respiratory failure, respiratory muscle weakness, bullous lung disease, bypassed upper airway, pneumothorax, pneumomediastinum 4. severe heart disease (including severe heart failure) 5. pathologically low blood pressure 6. an acute upper respiratory (including nasal, sinus or middle ear) inflammation or infection, or perforation of the ear drum 7. sores, abrasions, or skin or mucosal irritation on or around the nose. 8. known pregnancy 9. inability to provide informed consent 10. use of alpha blockers or short acting nitrates 11. permanent pacemaker 12. sustained non-sinus cardiac arrhythmia

Keywords: stroke sleep apnea
double-s: a wearable device for erectile dysfunction

Conditions: Erectile Dysfunction

Summary: the purpose of this study is to use a minimally invasive erectile device for patients suffering from erectile dysfunction.

the purpose of the study is to use a minimally invasive erectile device support to provide to patients suffering from erectile dysfunction the possibility to achieve satisfactory penetrating intercourse. the goal of this is to help men who have issues with erectile function (e.g.after radical prostatectomy for prostate cancer, vascular or metabolic erectile dysfunction non-responsive to phosphodiesterase-5 inhibitor medications, etc.) to have medication-free mechanical support for their penis in order to obtain sexual penetration satisfactorily.

Eligibility criteria:
inclusion criteria: * males \>18 years old suffering from any cause moderate to severe erectile dysfunction (e.g. ed after radical prostatectomy and/or radiation therapy for prostate cancer and or other pelvic malignancies affecting the sexual potency; emotional and psychological ed; organic vascular and/or metabolic ed etc.) * having a female partner willing to participate in the study exclusion criteria: * not willing to attempt sexual vaginal intercourse with their partner * inability to wear/operate the external penile device for any reason
comparison of two treatment strategies in patients with an acute coronary syndrome without st elevation

Conditions: CORONARY DISEASE

Summary: the acute coronary syndrome (acs) without st elevation is a frequent pathology. the main evolutionary risk of these patients is the coronary thrombosis and its self complications. the platelets aggregation plays a major role in the physiopathology of the acs. the therapeutic arsenal of the anti-thrombosis essentially resting on aspirin and heparin has been reinforced lately by the inhibitors of the glycoprotein anti gp iib/iiia. the profit of these products in the acs with or without st elevation, associated or not to coronarography, has clearly been demonstrated. this profit is more marked when patients are at high risk of complications. thus, the use of an anti gp iib/iiia is recommended among patients at "high risk" for whom a coronarography is planned, in the last international recommendations of the european cardiology society (esc), the american heart association and the american college of chest physician. otherwise, some authors have proposed an early invasive strategy based on coronarography with discordant results. the ideal delay of realization of this coronarography is unknown. it varies according to the studies between 2.5 hours to 48 hours. once again, patients at high risk seem to benefit the more of such a strategy if it is set precociously. objective to compare an invasive strategy associating an early administration of tirofiban and a coronarography achieved in the 6 hours after the randomization to a conservative strategy in a population of high risk patients with acs without st elevation. design multicentric, prospective, randomized study.

patient's selection patient of more than 18 years with a acs defined by a thoracic pain of more than 20 minutes that occurred during the last 24 hours, anomalies on ekg and one of the following criteria : diabetes; recurrence of coronary pain; precocious pain post-myocardial infarction; falling of the st segment of \> 1 mm; transient elevation of the st segment \> 1 mm; elevation of the i troponin, t troponin or cpk mb; hemodynamic instability; ventricular arrhythmia; timi score \> 5 therapeutic modes all patients receive : aspirin, clopidogrel, enoxaparine. trinitrin and analgesics are at the clinician's appreciation. besides, either they receive an anti gp iib/iiia: tirofiban (agrastat®) and are oriented in cardiology to have a coronarography in the six hours or they are oriented in cardiology to receive the classical treatment, guided by the investigations searching for signs of myocardial ischemia.

Eligibility criteria:
inclusion criteria: * high risk acs without st elevation exclusion criteria: * age \<18 years * pregnancy * persistence of the st elevation * recent left branch block * cardiac failure or cardiogenic shock (kilip 3 or 4) * treatment by anti-vitamin k * contra-indication to the use of one of the following treatments: aspirin, clopidogrel, enoxaparine, anti gp iib/iiia (tirofiban)

Keywords: coronary disease
childneph the canadian childhood nephrotic syndrome study

Conditions: Nephrotic Syndrome in Children; Nephrotic Syndrome, Minimal Change; Nephrotic Syndrome，Idiopathic

Summary: childneph is a pan-canadian project to observe clinical care for children with nephrotic syndrome. previous studies have indicated that there is wide practice variation in how health care providers treat this remitting and relapsing disease of childhood. the disease mechanism is not yet understood, and long-term use of steroids can affect children's health. this study involves assessment of routine clinical care and establishing a long-term patient registry for children with nephrotic syndrome.

childneph is an ongoing prospective longitudinal study of children with incident and prevalent nephrotic syndrome. children are recruited from 12 centres across canada and followed for at least 30 months. the project starting in august of 2013 with the goal of following 400 patients. data is collected at enrollment, beginning and end of each relapse, semi-annual visits and end of study. detailed prescription data is collected regarding glucocorticoids and all second line agents. all relapses are recorded with time to urinary remission of proteinuria. the investigators are moving towards registry based trials to determine optimal treatment protocols for nephrotic syndrome with an overall goal to minimize glucocorticoid exposure, a patient priority.

Eligibility criteria:
inclusion criteria: * diagnosis with nephrotic sydrome at initial presentation, first or second relapse exclusion criteria: * unable to participate in english or french * nephrotic syndrome is secondary to other disease * younger than one year old or older than 17 years
effect of kinesio taping on upper extremity performance in individuals with rounded shoulders

Conditions: Shoulder Pain

Summary: the objective of this research is to study the effect of kinesio tapes with functional correction technique in combination with exercise management to increase strength and decrease pain, in people with rounded shoulders. the study would be evaluated with the evaltechtm machine, (functional capacity assessment).

participants * age 25-50 years, male and female * people who have a shoulder condition. (by measuring in the supine position, distance from the posterior aspect of acromion to the bed\> 1 inch on both sides) * people with moderate to severe neck and shoulder pain (vas\> 3) * people who have to use their arms for work overall more than 3 hours per day for attaching the tape, the researcher will prepare a replacement shirt in case the for the convenience of tape, the experimental group, trained by certified kinesio tape, attached the kinesio tape. attaching the tape by using functional correction techniques, apply from the front of the acromion process to the spinous process t10 on both sides. measurements 1. the pressure of (average of peak force) of both arms (pounds) 2. the pulling force (average of peak force) of both arms (pounds) 3. time of overhead endurance test (tmt) (seconds) 4. visual analog scale (vas) 5. the distance from the posterior aspect of acromion to the bed (inches) process of measuring the evaluation 3 times 1. st after physical therapy treatment before attaching the kinase tape 2. nd evaluation period was 48 hours apart before the next treatment. 3. rd evaluation period is 1 week apart.

Eligibility criteria:
inclusion criteria: * age 25-50 years, male and female * people who have a shoulder condition. (by measuring in the supine position, distance from the posterior aspect of acromion to the bed\> 1 inch on both sides) * people with moderate to severe neck and shoulder pain (vas\> 3) * people who have to use their arms for work overall more than 3 hours per day exclusion criteria: * people with neck pain, fracture in the arm, and numbness * people who have pain and have limited shoulder movement of the shoulder joint * people who have had a history of spine / shoulder surgery * people with a history of allergies to cloth tapes * people who have rheumatoid arthritis that affects inflammation of the joints such as rheumatoid etc. * people receiving medication that affects their participation in the study * people with neurological symptoms * people with cognitive disabilities

Keywords: kinesio tape, functional correction, rounded shoulder
safety study of chinese herbal therapy to treat asthma

Conditions: Asthma

Summary: the purpose of this study is to determine the safety of an anti-asthma herbal medicine intervention (ashmi) in adult asthmatics and to see what effects ashmi has on certain parts of the immune system.

asthma is a major public health problem worldwide, particularly in westernized societies and has continued to increase in prevalence over the past two decades. inhaled corticosteroids have become the first-line treatment for persistent asthma even though significant side effects have been reported. new asthma medications, including leukotriene inhibitors and anti-ige, have shown only marginal benefits. patients have increasingly turned to complementary and alternative medicine (cam) for treatment of their asthma, despite the uncertainty of its benefits due a lack of well-controlled scientific studies. we have developed a chinese herbal formula composed of 3 herbs called ashmi. it has been previously shown in murine studies that ashmi (a formula containing ling zhi, ku shen and gan cao) has therapeutic effects on the major pathogenic mechanisms of asthma-airway hyperreactivity, pulmonary inflammation, and airway remodeling, as well as a down-regulating of th2 response. a subsequent study in 91 asthmatic patients in weifang, china found ashmi to be a safe and effective alternative to prednisone for treating asthma and exhibited a beneficial effect on th1 and th2 balance. based on these preliminary studies, we hypothesize that ashmi will be a safe medication in atopic patients with asthma and will lead to identifiable changes in serum immunologic markers.

Eligibility criteria:
inclusion criteria: * male and female subjects ages 18-40 and otherwise in good health as determined by medical history and physical examination * history of asthma documented by a physician * documentation of allergy to two or more common environmental allergens as evidenced by positive prick skin or rast testing * the subject agrees to participate in the study * females of childbearing potential must be inactive sexually or take effective birth control measures, as deemed appropriate by the investigator, for the duration of the study. exclusion criteria: * acute illness (such as cold, flu, etc.) within one week before the administration of study drug * any history of systemic disease that in the investigator's opinion would preclude the subject from participating in this study, including viral hepatitis infection (by patient self-report) * abnormal hepatic function * abnormal bone marrow function * abnormal renal function * clinically significant abnormal electrocardiogram * current uncontrolled moderate to severe asthma with fev1 \<80% predicted * participation in another experimental study within 30 days of this study * history of alcohol or drug abuse (by self report) * pregnant or lactating female subjects. females of childbearing potential will need a negative serum pregnancy test to be considered for this study * current smokers

Keywords: chinese herbal therapy asthma investigational new drug (ind) complementary and alternative medicine