Kornimate/medical-research-clean huggingface dataset:
prevalence of aspirin resistance in ischemic stroke patients at assiut university hospital

Conditions: Ischemic Stroke

Summary: * this study aims to assess the prevalence of aspirin resistance in patients with acute ischemic stroke and its importance in secondary stroke prevention. * effect of aspirin resistance on short and long term mortality and detection of its relationship with recurrence of stroke.

stroke is the rapidly developing loss of brain functions due to disturbance in the blood supply to the brain. it is the leading cause of adult disability in the united states and europe and currently the second leading cause of death, ranking after heart disease and before cancer, accounting for 10% of deaths worldwide . about 80-90% of strokes are caused by ischemia, and the remainder by hemorrhage . arterioarterial micro thromboembolism is an important etiological factor in the pathogenesis of ischemic stroke. platelet activation in cerebrovascular disease is associated with recurrent stroke and death, while inhibition of platelet function by antiplatelet drugs including aspirin lowers the risk of ischemic stroke. aspirin is an effective antiplatelet agent, exhibiting its action by irreversibly inhibiting platelet cyclooxygenase-1 enzyme, thus preventing the production of thromboxane a2 (txa2). it has been used in the primary and secondary prevention of thromboembolic vascular events. yet, some patients experience recurrent ischemic events despite optimal antiplatelet therapy. this has raised the possibility that these patients may be resistant to aspirin and generated much interest in identification of such patients with laboratory tests of platelet function. although many studies have demonstrated aspirin resistance in cardiovascular disorders including coronary artery disease, metabolic syndrome , and diabetes by certain tests of aspirin resistance, there are still concerns that these tests have not correlated closely with subsequent recurrent events, and have not reliably identified non-responders to antiplatelet therapy . in addition to the absence of any standardized approach to the diagnosis, there is currently no proven effective treatment for aspirin resistance. although aspirin resistance has been demonstrated as a possible risk factor for recurrent cardiovascular ischemic events, there is a lack of data correlating aspirin resistance and risk of cerebrovascular ischemic events

Eligibility criteria:
inclusion criteria: 1. at least 7 days of aspirin therapy (acetylsalicylic acid, 100 mg daily) prior to stroke onset 2. within 24 h of experiencing a new focal or global neurological deficit. 3. evidence of new or old ischemic infarct on ct brain or magnetic resonance imaging (mri). 4. with informed consents. 5. presence or not previous cerebrovascular event as previous history of transient ischemic attack (tia) before the onset of stroke. exclusion criteria: 1. patients with other neurological deficits due to stroke mimics or hemorrhagic insult. 2. patients is subjected to anticoagulant treatment (atrial fibrillation, valve replacement, others).
effects of mild hypobaric hypoxia on sleep and post-sleep performance

Conditions: Altitude; Hypoxia; Environmental Sleep Disorder

Summary: hypobaric hypoxia (decreased oxygen supply to body tissues due to low atmospheric pressure) caused by exposure to high altitude disrupts sleep. sleep deprivation is associated with degraded post-sleep performance of neurobehavioral tasks. the lowest altitude at which sleep and/or post-sleep performance are affected is not known. the study hypothesis is that sleep and/or post-sleep performance of neurobehavioral tasks will occur due to hypobaric hypoxia at altitudes of 8,000 or less.


Eligibility criteria:
inclusion criteria: * healthy * age 30 to 60 years exclusion criteria: * sleep disorders or abnormal sleep patterns * mood or psychiatric disorders including claustrophobia * altitude exposure above 5,000 ft in the previous 2 months * born or raised at terrestrial altitude 5,000 ft or greater * conditions that would disqualify for faa medical certificate * acute medical conditions

Keywords: high altitude sleep altitude illness neurobehavioral manifestations psychomotor performance mood states
peritoneal closure versus non closure during open appendectomy

Conditions: Acute Appendicitis

Summary: there has been no consensus over closure versus non closure of peritoneum during abdominal operations. the aim of this study is to compare the effect of peritoneal closure versus non closure over postoperative pain, early complications and life quality.

there has been no consensus over closure versus non closure of peritoneum during abdominal operations. in literature, few reports suggested that peritoneal closure may prolong the operation time, may increase the costs and has a probable aggravating effect on postoperative pain. in addition, there have been some reports that suggest non closure of peritoneum may not increase the postoperative complications. the need of further studies to clarify the effect of peritoneal closure versus non closure on postoperative pain and life quality especially has been specified in some literature. the aim of this study is to compare the effect of peritoneal closure versus non closure over postoperative pain, early complications and life quality.

Eligibility criteria:
inclusion criteria: * patients with acute appendicitis * age between 18-65 years exclusion criteria: * preoperatively diagnosed intraabdominal abcess * intraoperatively diagnosed free purulent fluid in abdominal cavity * pregnancy * malignancy history * mental retardation * chronical renal failure * chronical liver disease * diabetes mellitus * patients' denial of participation to study

Keywords: peritoneal closure appendectomy postoperative pain life quality
clinical utility of olfactory rehabilitation: treatment for pacients with neurosensorial anosmia

Conditions: Anosmia; Occupational Therapy; Brain Injuries, Traumatic

Summary: the aim of our study was to compare the recovery of smell in people suffering posttraumatic olfactory impairment following a systematic olfactory rehabilitation performed by occupational therapists to natural recovery in a control posttraumatic group of patients.

forty participants started the study: 20 for the control group and 20 for the treatment group. the mean of the time span between the traumatic event and the first visit in the rehabilitation group was longer than 22 months, time enough to wait any kind of spontaneous recovery. in order to establish correct comparisons, the investigators analyzed whether both groups of participants (control group and treatment group) were homogeneous or not regarding the age, gender, time span between the traumatic event and the first visit to the office, brain damage and loss of conscience. investigators administered visual analogic scale (vas), cccrc olfactory test and quality of life questionnaire (rsdi) to both groups at the beginning of the study and 12 months late

Eligibility criteria:
inclusion criteria: * olfactory loss participants from institution to the smell \& tast office, otorhinolaryngology unit, hospital universitario fundación alcorcón. all participants provided written informed consent exclusion criteria: * no sign informed consent

Keywords: occupational therapy anosmia brain injuries, traumatic
pacap38´s (pituitary adenylate cyclase-activating polypeptide) headache inducing characteristics and effects on the cerebral blood flow

Conditions: Migraine Without Aura

Summary: to investigate headache score and accompanying symptoms during and after infusion of pacap38 i migraine patients

to investigate headache score and accompanying symptoms during and after infusion of pacap38 changes in regional cerebral blood flow (rcbf) in the area supplied by middle cerebral artery (mca), blood flow in mca, diameter of the superficial temporal artery (sta) and radial artery (ra)

Eligibility criteria:
inclusion criteria: * healthy migraine patient without aura * aged 18-50 * 50-100 kg * fertile women must use safe contraceptives (iud, oral contraceptives, surgical sterilisation and long lasting gestagen. exclusion criteria: * tension type headache more than five times/month * other primary headaches * daily medication except contraceptives * drug taken within 4 times the halflife for the specific drug except contraceptives * pregnant or lactating women * exposure to radiation within the last year * headache within the last 48 hours before start of trial * hypertension * hypotension * respiratory or cardiac disease
quality of life assessment of radiotherapy in recurrent head and neck cancer

Conditions: Head and Neck Cancer; Gynecologic Cancer; Cervical Cancer; Endometrial Cancer

Summary: the purpose of this study is to examine the uses of a mobile health-based assessment and symptom monitoring platform.

this study will involve patients who have been diagnosed with head and neck or gynecologic cancers and are receiving radiation treatments via the quad shot regimen. it is a single arm pilot trial designed to provide information on the ease of use, feasibility, and perceived usefulness of a smartphone application to monitor symptoms and quality of life during cancer treatment, as well as assess barriers to care and perceptions of the smartphone app. patients will download the study app onto their personal smartphone, if the phone is compatible with the app, or a study smartphone will be loaned to them. the smartphone app will first ask patients to complete the 15-25 minute baseline survey, followed by one daily brief survey that ask about symptoms, quality of life, and barriers for 75 days. at the end of this period, the smartphone app will prompt the patient to complete a final survey, followed by a brief in-person or telephone interview to assess opinions about the app. patients' symptoms, treatment effects, medication adherence, pain, quality of life, and general barriers to care will be assessed with questionnaires to measure the impacts of the mobile health-based assessment platform. results from this study will be for research only and will not impact treatment decisions.

Eligibility criteria:
inclusion criteria: * age 18 years and older * written informed consent and any locally-required authorization obtained from the patients prior to performing any protocol-related procedures, including screening evaluations * pathologically (histologically or cytologically) proven diagnosis of cancer of the head and neck (nasopharynx, oral cavity, oropharynx, hypopharynx, larynx, or unknown primary) or gynecologic cancers (cervical and endometrial) * locally recurrent or metastatic hnc or gyn cancer not deemed amenable to curative-intent salvage therapy, in whom at least six months have passed since their prior rt, if received * must have evaluable lesion per recist v1.1 * patients agree to provide their smoking history prior to registration * ecog performance status of 0-2 exclusion criteria: * prior radiotherapy to the region of the study cancer within less than 6 months * patients who have received prior radiation therapy and who, in the opinion of the treating radiation oncologist, cannot be reirradiated safely without excess risk of severe toxicity given prior radiation dose to critical structures. * patients with known contraindications to radiotherapy, including inherited syndromes associated with hypersensitivity to ionizing radiation (e.g., ataxia-telangiectasia, nijmegen breakage syndrome) * female patients who are pregnant

Keywords: radiation therapy mobile health quadshot quality of life
efficacy of square- stepping exercises in individuals with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: square stepping exercises can promote correct foot placement, fast and coordinated step patterns, and sensory-motor interaction. the aim of this study is to examine the effect of square stepping exercises on mobility, balance and knee joint position sense in individuals with multiple sclerosis.

multiple sclerosis (ms) is a chronic, inflammatory, autoimmune disease of the central nervous system that results in neurological disability. complex gene-environment interactions play a role in the etiology of multiple sclerosis. multiple sclerosis is more common in women than men, with a ratio ranging from 2:1 to 3:1. ms is a very heterogeneous disease and it can have very variable clinical signs and symptoms, including motor, sensory, autonomic and cognitive disorders, depending on the region of the central nervous system. balance and mobility disorders are the leading symptoms of ms. in addition, somatosensory disorders are frequently encountered as the initial symptom. disorders in position sense, which is one of the components of somatosensory sense, is an important determinant of limitations during dynamic activities such as walking and balance. in order to reduce disability and improve function in individuals with multiple sclerosis, square stepping exercises protocol will be given to one group and a home exercise program protocol to the other group. created by shigematsu and okura to improve balance and reduce the risk of falling, the square stepping exercises is performed on a thin exercise mat divided into 40 small squares of 250 cm x 100 cm. there are a number of step patterns that must be followed by the participants. certain step patterns will be repeated 3-5 times to the participants and the participant will be asked to repeat the same pattern. as a home exercise protocol, a program consisting of frenkel exercises developed by professor heinrich sebastian frenkel for the treatment of gait, balance and coordination will be applied. square stepping exercises can promote correct foot placement, fast and coordinated step patterns, and sensory-motor interaction. the aim of this study is to examine the effect of square stepping exercises on mobility, balance and knee joint position sense in individuals with multiple sclerosis.

Eligibility criteria:
inclusion criteria: * having a disability score of less than 4 * being between 20-50 years old * not having an attack in the last month * patients without lower extremity spasticity according to modified ashworth scale (mas) exclusion criteria: * having a neurological disease other than multiple sclerosis * having an multiple sclerosis attack during the study * having had orthopedic surgery affecting balance * presence of cognitive and psychiatric influences that will affect participation in the study * having a cardiovascular or pulmonary history that would inhibit participation in the study * have received steroid and/or immunosuppressive therapy in the past four weeks

Keywords: multiple sclerosis mobility balance position sense
oral biopsies: evaluation of the post-surgical discomfort

Conditions: Quality of Life; Biopsy Wound; Surgical Wound; Healing Surgical Wounds

Summary: aim of this study is to evaluate the post-operative course in patients undergoing diagnostic or therapeutic oral mucosal biopsies. to evaluate the wound healing, all variables connected with the surgery (including post-operative complications) were recorded. to evaluate the psychological and behavioral impact of the post-operative discomfort, two survey tools were administered: ohip-14 and visual number scale of pain (vns) were administered at 6h, 7 days and 21 days after biopsy.


Eligibility criteria:
inclusion criteria: * no systemic or local contraindications for surgical treatment * need for an oral biopsy (both excisional and incisional). exclusion criteria: since no absolute contraindications to oral biopsies are reported, no exclusion criteria were selected for this study, but if any relative contraindication was present (i.e. bleeding disorders) biopsy was performed after the resolution of the problem
a randomized controlled trial of individual therapy for first episode psychosis

Conditions: Psychosis

Summary: in the first year of treatment after a fe of scz, 75% to 90% of patients achieve remission from psychotic symptoms. however, approximately 40% of fe patients are non-adherent to medication regimes and more than 60% have intermittent periods of gaps of non-adherence. relapse rates are high with 82% of patients relapsing at least once within 5 years. unfortunately even amongst those who do achieve full remission from psychotic symptoms, functional recovery remains a major challenge for patients. all the evidence suggests that individuals with scz do best with a combination of pharmacology and psychosocial intervention. cognitive-behavior therapy (cbt) is gaining recognition as an effective treatment in scz and is in fact the only psychosocial treatment in scz with proven durability at short term follow-up. although it is currently being used, the investigators need to learn more about the impact of cbt on fe scz especially as experts are advocating for cbt to be a critical component of fe clinical services.

the primary problem to be addressed is the incomplete functional recovery following a fe of scz and whether cbt is an effective treatment to aid this recovery. if cbt were to positively impact recovery in the fe we then need to address (i) which mechanisms are responsible for this improvement, and (ii) whether this treatment is effective for all fe patients.

Eligibility criteria:
inclusion criteria: 1. stabilized outpatients, 2. ages 16 to 35 3. meet dsm-iv criteria for: schizophrenia, schizophreniform disorder, brief psychotic disorder, delusional disorder, schizoaffective disorder, substance induced psychotic disorder, or psychotic disorder nos. participants who also meet dsm-iv criteria for substance abuse or dependence will not be excluded. 4. are competent and willing to give consent 5. are within 12 months of admission to the fepp for a fe. exclusion: 1. serious risk of suicide or violence to others 2. a primary diagnosis of drug-induced psychosis or psychosis due to a general medical condition.

Keywords: cognitive behavioural therapy psychosis
a study to assess the safety, tolerability and preliminary efficacy of hh-120 for the treatment of covid-19

Conditions: COVID-19

Summary: this is a randomized, double-blind, placebo-controlled phase 1 study in participants over the age of 18 years with mild to moderate covid-19. this study aims to assess the safety, tolerability and preliminary antiviral effect of hh-120. this study includes dose escalation phase and dose expansion phase.


Eligibility criteria:
inclusion criteria: * the escalation phase: 1. participants are aged 18 to 65 years (inclusive at the time of informed consent) 2. participants are mild or moderate covid-19 patients. 3. participants have one or more mild or moderate covid 19-related symptoms as defined by the fda (see the diagnosis and main criteria for inclusion) with the onset of symptoms ≤ 3 days prior to the randomization. * the expansion phase: 1. participants are ≥18 years of age at the time of randomization. 2. participants are mild or moderate covid-19 patients. 3. participants have one or more mild or moderate covid 19-related symptoms as defined by the fda (see the diagnosis and main criteria for inclusion) with the onset of symptoms ≤ 5 days prior to the randomization. exclusion criteria: * pregnant or lactating at screening or planning to become pregnant (self or partner) at any time during the study, including the follow-up period. * prior or ongoing medical conditions, medical history, physical findings, or laboratory abnormality that, in the pi's (or delegate's) opinion, could adversely affect the safety of the participant or that might interfere with the conduct of the study. * presence of any underlying physical or psychological medical condition that, in the opinion of the pi, would make it unlikely that the participant will comply with the protocol or complete the study per protocol. * have known allergies to any of the components used in the formulation of the study intervention.
the applying of acupressure and abdominal massage to improving constipation in stroke patients.

Conditions: Acupressure; Abdominal Massage; Constipation; Stroke Patients

Summary: experimental research design with two-group repeated-measure design. experimental group was pressing the hegu (li 4), zusanli (st 36) , tianshu(st 25) and abdominal massage for eight minutes total, press once in the morning and afternoon, seven days total and two days for follow the trail. control group was pressing sham ponits. research tools to self semi-structured questionnaire collected data on patient's diet, activity, medication, defecation patterns, subjective defecation feelingauscultation bowel sounds like.

experimental research design with two-group repeated-measure design. the investigators estimate there are recruit fifty patients from related rehabilitation hospital of a medical center in taichung, central taiwan, using randomization put patients in experimental group and control group. experimental group pressing the hegu (li 4), zusanli (st 36) , tianshu(st 25) and abdominal massage for eight minutes total, press once in the morning and afternoon, seven days total and two days for follow the trail. control group was pressing sham ponits. research tools to self semi-structured questionnaire collected data on patient's diet, activity, medication, defecation patterns, subjective defecation feelings, and auscultation bowel sounds like. the investigators expected the results of this study can provide clinical nursing care for stroke patients of reference, to improve quality of care, and increase acupressure to improve the empirical data of stroke in patients with constipation.

Eligibility criteria:
inclusion criteria: 1. patients who were diagnosed as stroke, and in stability phase. 2. patients who had constipation symptoms. 3. patients whose platelets counts more than 150,000 / μ. exclusion criteria: 1. consciousness is not clear. 2. the physician diagnosed with irritable bowel syndrome.

Keywords: acupressure abdominal massage constipation stroke patients traditional chinese medicine
evaluation of watchman left atrial appendage occlusion device in patients with atrial fibrillation versus rivaroxaban

Conditions: Atrial Fibrillation; Stroke

Summary: this is a prospective, multi-center, randomized, pilot study comparing the watchman left atrial appendage occlusion device with rivaroxaban therapy in patients with non-valvular atrial fibrillation.


Eligibility criteria:
inclusion criteria: * paroxysmal, persistent or permanent non-valvular atrial fibrillation * eligible for laao and long-term rivaroxaban therapy * calculated cha2ds2-vasc score of 2 or greater. exclusion criteria: * contraindicated/allergic to aspirin, clopidogrel and novel oral anticoagulants. * indicated for clopidogrel therapy or has taken clopidogrel within 7 days prior to enrollment. * history of atrial septal repair or has an atrial septal defect/patent foramen ovale device. * history of valvular heart disease. * implanted mechanical valve prosthesis. * new york heart association class iv congestive heart failure or left ventricular ejection fraction less than 30%. * patient has left atrial/left atrial appendage thrombus screened by echocardiography * platelet\<100\*109/l or hemoglobin\<100g/l * expected lifespan less than 1 years