Kornimate/medical-research-clean huggingface dataset:
pain phenotyping of patients with bone cancer pain

Conditions: Pain; Bone Metastases; Metastatic Breast Cancer

Summary: the study aims to describe and quantify pain related to metastatic bone disease. the study will include 50 subjects with disseminated breast cancer and 20 healthy subjects. the pain will be described and quantified through (1) pain specific questionnaires, (2) quantitative sensory testing that assess sensory changes to cold, heat and mechanical stimulation of the skin overlying the metastatic site, and (3) conditioned pain modulation that investigates impairment of the endogenous inhibitory pain pathway in humans.

cancer patients in palliative care point to pain as their most important and most feared symptom. bone metastases are a common cause of cancer pain, and the patients are prone to transient severe pain exacerbations (breakthrough pain), which can occur spontaneously or be triggered by movement. patients with bone metastases experience pain of such high intensity, that it affects not only physical activity, but also sleep, mood and social relations. this results in poor quality of life for the patients and poses an increasing clinical and socio-economical problem. the pain is difficult to treat and often requires high opioid doses which results in unacceptable adverse effects, and there is an unmet need of novel therapeutic options and treatment strategies. animal models of cancer-induced bone pain have suggested that pain arising from metastatic bone disease involve neuropathic and nociceptive pain mechanisms and, importantly, mechanisms that are specific to cancer-induced bone pain. significant neuronal sprouting can occur at the metastatic site, and the inherent pain control system is found altered in animal models of cancer-induced bone pain; a system that can be exploited for treatment strategies and in the development of new analgesia. yet, it is not known how the pre-clinical findings translate to patients. quantitative sensory testing is a psychophysical method that uses a battery of sensory stimuli with predetermined physical properties, thus allowing the capture and quantification of stimulus-evoked negative and positive sensory phenomena in humans. conditioned pain modulation is a psychophysical experimental measure of the endogenous pain inhibitory pathway in humans, which can be used to detect an impairment of the descending inhibitory pain pathway. this study aims to perform pain phenotyping of patients suffering from cancer-induced bone pain, through pain specific questionnaires, quantitative sensory testing and conditioned pain modulation.

Eligibility criteria:
inclusion criteria: * woman * primary breast cancer * bone metastases * competent exclusion criteria: * not fluent in spoken danish * chemotherapy or radiation within the last 3 months * other chronic pain disease that may affect the quantitative sensory testing or conditioned pain modulation * alcohol or medicine abuse * pregnancy
efficacy and safety of nitazoxanide in preventing recurrence of hepatic encephalopathy

Conditions: Hepatic Encephalopathy

Summary: efficacy and safety of nitazoxanide in preventing recurrence of hepatic encephalopathy.

clinical study evaluating the efficacy and safety of nitazoxanide in preventing recurrence of hepatic encephalopathy.

Eligibility criteria:
inclusion criteria: * cirrhotic patient with at least one previous episode of hepatic encephalopathy. * adult patients aging from 20 to 65 years old exclusion criteria: * active git bleeding. * major psychiatric illness (psychosis \& epilepsy). * renal insufficiency (s.cr 2mg/dl).
the establishment of china bronchiectasis registry and research collaboration

Conditions: Bronchiectasis

Summary: the investigators meant to establish a multi-centered bronchiectasis patient registry for chinese bronchiectasis patients. this would be the first bronchiectasis registry in china. patients with all kinds of bronchiectasis would be enrolled.

a multi-centered bronchiectasis patient registry would be founded, which will include patients from three teaching hospital (ruijin hospital, zhongshan hospital and shanghai pulmonary hospital) in shanghai at the beginning. the network will be promoted to other cities and different places in china. patients with bronchiectasis would be enrolled and detailed information would be recorded. follow-up of patients would provide more information on the prognosis of disease. optimal treatment studies for the patients will be initiated one by one based on the network. the investigators are committed to promoting clinical research and education in bronchiectasis, through sharing of protocols, research idea and expertise.

Eligibility criteria:
inclusion criteria: * patients diagnosed with bronchiectasis according to 'non-cystic fibrosis bronchiectasis guideline' published by british thoracic society in 2010. * patients who are willing to sign the consent form and participate in the study. exclusion criteria: * patients with incomplete essential information, which is needed for the integrity of data analysis. essential information include ct images, respiratory sample cultures, spirometry and exacerbation history for at least one year. * patients under 18 years old.

Keywords: bronchiectasis multi-centered registry
thromboprophylaxis in oesophageal cancer patients

Conditions: Esophageal Neoplasms; Thrombosis; Thromboembolism

Summary: the purpose of the study is to examine the efficacy and safety of prolonged thromboprophylactic treatment with fragmin® in oesophageal cancer patients undergoing intended curative surgery.

hypotheses 1. the intervention group of oesophageal cancer patients, who receive prolonged thromboprophylaxis with fragmin® has a lower vte risk, expressed by a lower prothrombin fragment f1+2, 30 days after surgery than the control group, who receive fragmin® for 10 days. 2. the intervention group does not demonstrate an increased bleeding tendency compared with the control group. primary endpoint the primary endpoint is the difference in prothrombin fragment f1+2 30 days after surgery between the intervention and the control group. secondary and safety endpoints the secondary endpoints are incidence of bleeding, vte and mortality 30 days and one year after surgery. study design the study is comprised of three specific objectives, presented in three work packages (wp): * wp1: randomization of 100 oesophageal cancer patients undergoing intended curative surgery to either a 10 or 30-day prophylactic lmwh-regime. * wp2: investigation of the coagulation in the wp1 population. the aim is to substantially improve understanding of the coagulation pathophysiology and the mechanisms behind the increased thromboembolic risk in oesophageal cancer patients. * wp3: the lectin pathway complement proteins are suspected to play a role in the increased risk of thrombosis in cancer. we aim to examine this further by measuring complement protein levels in the wp1 population and investigate if there is a correlation between complement levels and changes in the coagulation.

Eligibility criteria:
inclusion criteria: 1. cancer located in oesophagus and/or cardia. 2. candidate for intended curative surgery. 3. age \> 18 years. exclusion criteria: 1. known inherited bleeding disorder. 2. unable to provide informed consent. 3. arterial or venous thromboembolic events within the last three months. 4. on-going anticoagulant treatment (vitamin k antagonists or direct oral anticoagulants). 5. pregnant or has given birth within the last three months. 6. known allergy to the trial drug dalteparin (fragmin®).

Keywords: esophageal cancer
preventing contrast induced nephropathy after transcatheter aortic valve replacement

Conditions: Aortic Valve Disease; Chronic Kidney Disease; Contrast Induced Nephropathy; Acute Kidney Injury

Summary: chronic kidney disease (ckd) and (subsequent) acute kidney injury are frequent in patients undergoing transcatheter aortic valve implantation (tavi). moreover, these patients are easily hypervolemic and susceptible for cardiac decompensation. prevention of contrast induced nephropathy (cin) has not yet been studied in these patients, and evidence on different strategies is urgently needed. the objective of this study is to evaluate the efficacy of 250ml 1.4% sodium bicarbonate versus hypotone saline (0.65% sodiumchloride) hydration prior to tavi in patients with ckd to prevent cin.


Eligibility criteria:
inclusion criteria: 1. patient has provided written informed consent. 2. patient is undergoing tavi. 3. patient has an estimated gfr \<60ml/min/1.73m2. exclusion criteria: 1. patient has end-stage kidney disease requiring dialysis. 2. emergent tavi (planned before next working day). 3. recent exposure to radiographic contrast agents (within 2 days prior to the tavi). 4. allergy to contrast agent. 5. planned administration of dopamine, mannitol, fenoldopam or n-acetylcysteine during the intended time of the study. 6. need for continuous hydration therapy (e.g. sepsis). 7. multiple myeloma. 8. contra-indication to sodium bicarbonate.

Keywords: transcatheter aortic valve implantation transcatheter aortic valve replacement
multimodal pt with and without proprioceptive training in lumber fjs

Conditions: Facet Joint Pain

Summary: this will be a randomized clinical trial. the study will be conducted at pakistan railways general hospital rawalpindi and riphah international hospital islamabad. patients with fjs will be included. the aim of this study is to find the comparative effects of multimodal physical therapy treatment and proprioceptive training along with multimodal physical therapy treatment on pain, lumbar ranges of motion, disability, fatigue, lumbar lordosis curvature and balance. participants will be assessed for pain, lumbar range of motions, lumbar lordosis, disability, fatigue and balance before treatment. the intervention duration is 06 weeks, 03 sessions per week will be given to all participants. pain and lumbar ranges of motion will be measured on every visit. at the end of 06th week final readings for functional status, fatigue level, lumbar lordosis angle, fall risk and limits of stability will also be recorded. data will be analyzed by spss v.23.


Eligibility criteria:
inclusion criteria: * patients with facet joint syndrome diagnosed by standard criteria. this criterion includes: * one point tenderness under x-ray radiography * kemp sign. * catching pain. * pain increases with lumbar extension. * pain with bilateral slr. * or pain diminishes with medial branch block or facet joint block. * provocation maneuver. acevedo sign (facet stress sign) unilateral facet palpation percussion spinal test impaired range of motion jump test * revel's criteria 05 out of 07- 1. age greater than 65 years and pain that was not exacerbated by coughing, not worsened by hyperextension, not worsened by forward flexion, not worsened when rising from flexion, not worsened by extension-rotation, and well-relieved by recumbency. standing flexion, returning from standing flexion, standing extension, the extension rotation test. * on biodex balance system (bbs), overall stability index between 0.7-2.8. * on biodex balance system (bbs) limits of stability anterior: less than 80, posterior: less than 40 and lateral: less than 160 (80 on each side) 75% los (moderate level). * nprs ratings greater than 4 * constant or intermittent pain worsening on repeated movements exclusion criteria: * t-score of -2.5 or lower. * bmi is 30.0 or higher. * patients with lumbar postural syndrome * patients with lumbar instability * post laminectomy/discectomy * spondylolisthesis * osteoporosis/fractures * cauda equine syndrome * recent history of spinal trauma or surgery * lumbar myelopathy * patients with known metabolic diseases * participants having less than 20% odi scoring

Keywords: low back pain facet joint range of motion balance fatigue lordosis
cr9112792, a follow-up of study cr9108963

Conditions: Osteoporosis

Summary: the purpose of this study is to determine whether bone mineral density has increased in a subgroup of postmenopausal osteoporotic women from study cr9108963, between 6 and 12 months following cessation of ronacaleret therapy.

cr9112792 is a follow-up study of cr9108963, the 12 month dose ranging study of ronacaleret (sb-751689), a calcium sensing receptor antagonist, in postmenopausal women with osteoporosis. cr9108963 evaluated the effects of ronacaleret (100mg, 200mg, 300mg, 400mg) on bone mineral density (bmd), safety and tolerability in comparison with placebo and 2 active comparators, alendronate and teriparatide. cr9108963 was terminated earlier than planned due to an observed lack of efficacy in lumbar spine and hip bmd. in this study we will follow-up subjects between 6 and 12 months after they discontinued treatment with ronacaleret to evaluate the potential for mineralization of bone following cessation of ronacaleret therapy. subjects at pre-specified sites from the cr9108963 placebo, 200mg, 300mg and 400mg dose groups will be included in this study.

Eligibility criteria:
inclusion criteria: * informed consent: subject is willing and able to provide written informed consent. * subjects: subjects must have completed through the month 12 visit of study cr9108963, or have had an early withdrawal visit on or after their month 10 visit. * dxa: subjects must have either a final evaluable spine or hip dxa scan in cr9108963 as confirmed by synarc, taken within 4 weeks of the last dose of study medication. * study medication: subjects must have been on placebo or ronacaleret 200mg, 300mg or 400mg for ≥299 days in study cr9108963. exclusion criteria: * any treatment with a pth-based therapy or strontium ranelate after discontinuation of treatment in study cr9108963. * chronic systemic corticosteroid \[e.g., glucocorticoid, mineralocorticoid\] treatment of more than 2 intra-articular injections within the past year or use of oral, parenteral, or long-term, high-dose inhaled corticosteroids. treatment with any topical corticosteroid will not exclude the subject from participating. * treatment with any topical corticosteroid will not exclude the subject from participation. * treatment with fluoride (dose greater than 10mg/day) for osteoporosis after discontinuation of treatment in study cr9108963. * administration of any investigational drug after discontinuation of treatment in study cr9108963. * subject who, in the opinion of the investigator, is unfit for this study or unable to comply with the requirements of the protocol.

Keywords: bone mineral density calcium-sensing receptor antagonist ronacaleret postmenopausal osteoporosis
swiss study on vitamin d and calcium in nursing homes

Conditions: Aging; Vitamin Deficiency

Summary: residents of nursing homes are endangered by malnutrition and vitamin d deficiency. our study checks compliance with swiss federal recommendations on vitamin d and calcium supplementation among residents of a swiss nursing home. a peer physician-applied recommendation on compliance with the federal recommendations with individual evaluation of the residents will be sent to the physicians in care. after one year, data will be collected again.

the investigators plan to get a complete sample of all inhabitants, so the only inclusion criterion is to get an informed consent either from the residents or from their relatives. the following data will be recorded: year of birth, gender, height, weight, blood pressure and heart rate, daily calcium intake from diet, nursing home scales on pain, depression, dementia and activities of daily life, date of entry to the home, diagnosis and medication lists. from a venous blood sample the investigators get: calcium, phosphate, albumin, creatinin, 25-hydroxyvitamin d, parathormone (intact). primary endpoint: proportion of medication lists of residents complying with federal recommendation on vitamin d and calcium supplementation. secondary endpoints: 25-hydroxyvitamin d levels, effect of an intervention with a nursing home-applied recommendation to the physicians.

Eligibility criteria:
inclusion criteria: * resident of nursing home on qualifying date * written informed consent by residents or their relatives exclusion criteria: * refusion of participation

Keywords: nursing home vitamin d supplements calcium supplements guideline adherence
study of colchicine to treat acute pericarditis and prevent recurrences

Conditions: Pericarditis

Summary: the purpose of the study is to determine whether colchicine is safe and effective in the treatment of acute pericarditis and the prevention of subsequent recurrences.

colchicine is safe and effective in the management of recurrent pericarditis after failure of conventional treatment. preliminary data have shown that it may be effective also in treatment of the index attack of pericarditis and the prevention of further recurrences. comparisons: the study will compare the safety and efficacy of colchicine in the treatment of acute pericarditis and the primary prevention of recurrences. colchicine will be used in addition to conventional treatment.

Eligibility criteria:
inclusion criteria: * patients with acute pericarditis (index attack) * age≥ 18 years * informed consent exclusion criteria: * suspected neoplastic, tuberculous, or purulent etiology * known severe liver disease and/or elevated transaminases \>1.5 times the upper limit of normality * serum creatinine \>2.5 mg/dl * serum creatine kinase (ck) over the upper limit of normality or known myopathy * known gastrointestinal or blood disease * pregnant or lactating women or women not protected by a contraception method * known hypersensibility to colchicine * treatment with colchicine at enrolment

Keywords: pericarditis recurrence therapeutics prevention colchicine
whole blood biospecimen collection for subjects with fanconi anemia

Conditions: Fanconi Anemia

Summary: the primary study objective is to collect biospecimen samples (e.g., blood) from participants diagnosed with fanconi anemia. the biospecimens will be used to create a biorepository that can be used to identify disease associated biomarkers and potential targets with immune and multi-omics profiling. the disease sample collection and analysis will be the foundation for an extensive network of biospecimen access and linked datasets for future translational research.


Eligibility criteria:
inclusion criteria: * the participant is willing and able to provide written informed consent * the participant is willing and able to provide appropriate photo identification * participants aged 18 to 85 * participants have been diagnosed with fanconi anemia complementation group a exclusion criteria: * participants who are pregnant or are nursing * participants with a known history of hiv, hepatitis, or other infectious diseases participants who have taken an investigational product in the last 30 days participants who have experienced excess blood loss, including blood donation, defined as 250 ml in the last month or 500 ml in the previous two months
visual outcomes of subjects bilaterally implanted with restor aspheric +4 vs. tecnis or acri.lisa

Conditions: Cataract

Summary: this is a study to compare visual outcomes of subjects bilaterally implanted w/restor to subjects bilaterally implanted with the tecnis multifocal intraocular lens (iol) or acri.lisa iol


Eligibility criteria:
inclusion criteria: * diagnosed with cataracts exclusion criteria: * preexisting condition likely to confound results; 1 d astigmatism by preoperative k-readings

Keywords: restor
hd11 for intermediate stages

Conditions: Hodgkin´s Lymphoma

Summary: this study is designed to (1) compare the efficacy of the beacopp regimen with that of abvd as a 4-cycle chemotherapy combined with an involved field irradiation and (2) to define the optimum radiation dose comparing of 30 to 20 gy in the same context.


Eligibility criteria:
inclusion criteria: * hodgkin´s lymphoma (histologically proven) * cs (ps) ia, ib, iia, with one of the risk factors a-d cs (ps) iib only with risk factor c or d 1. bulky mediastinal mass (\> 1/3 maximum transverse thorax diameter) 2. extranodal involvement 3. esr \> 50 (a), \> 30 (b-symptoms) 4. 3 or more lymph node areas involved * written informaed consent exclusion criteria: * leukocytes \<3000/microl * platelets \<100000/microl * hodgkin´s disease as "composite lymphoma" * activity index (who) \< grade 2

Keywords: hodgkin´s lymphoma intermediate stages
role of chewing gum in reducing post operative ileus after reversal of ileostomy

Conditions: Postoperative Ileus

Summary: postoperative ileus is generally referred to as the transient impairment of bowel motility after abdominal or other surgery and diagnosed by postoperative abdominal pain vomiting constipation and distension. the potential complications of prolonged poi include increased postoperative pain, increased nausea and vomiting, pulmonary complications, poor wound healing, delay in resuming oral intake, delay in postoperative mobilization, prolonged hospitalization, and increased health-care costs. the estimated economic impact of poi in the united states is $7.5 billion per year, excluding the expenses of work loss. in view of these complications and economic burden a number of pharmacologic and non-pharmacologic strategies have been adopted by the doctors all over the world to reduce the burden of postoperative ileus.these programs involve transverse or curved surgical incisions, removal of nasogastric tubes at the end of anesthesia, intraoperative and postoperative analgesia, early postoperative feeding, mobilization, and gum chewing. the use of gum chewing has emerged as a new and simple modality for decreasing poi. and reviews have concluded that there is consistent benefit for patients from gum chewing after the intestinal surgery; colonic surgery and gynecological surgery. this study is based on the hypothesis that postoperative gum chewing is beneficial in prevention of postoperative ileus after reversal of ileostomy.


Eligibility criteria:
inclusion criteria: 1. patients of either gender with age ranging from 15 to 60 years. 2. patients whose ileostomies were made for typhoid or tuberculous perforation 3. patients with no distal obstruction on loopogram. exclusion criteria: - 1. patients with age less than 15 years and greater than 60. 2. patients having co-morbid factors such as diabetes and ischemic heart disease. 3. patients whose ileostomy was made for any condition other than typhoid or tuberculosis.
the effect of reflexology massage and passive music therapy intervention before burn dressing

Conditions: Burn Degree Second; Burn Degree Third

Summary: reflexology massage applied before burn dressing reduces pain, anxiety and sleep problems

reflexology massage regulates blood circulation and energy, gives a feeling of relaxation and provides homeostasis. during reflexology massage, relaxation music is recommended because it contributes to the relaxation of the individual. in the literature, reflexology massage and music therapy are used in different pain management, and these methods reduce anxiety and improve sleep quality. however, there is no study in which reflexology massage and passive music therapy are used to reduce pain, anxiety and sleep problems associated with dressing of burn individuals. it is thought that reflexology massage and passive music therapy will reduce pain, anxiety and sleep problems in dressing changes of burned individuals.

Eligibility criteria:
inclusion criteria: * over 18 years, * illiterate, * without any mental and psychological disease and able to communicate with the assessor * no hearing problems, * moderate or severe burns, * 2 days or more after burn injury, * proliferation phase of wound healing, * no open wound, infection or circulatory problems in the area where reflexology will be applied. * not having diabetes, * not using any pre-dressing complementary medicine, * non-pregnant, * having no pacemaker, * agreeing to participate in the study. exclusion criteria: * patients who do not meet the inclusion criteria.

Keywords: burn reflexology music pain anxiety sleep