Kornimate/medical-research-clean huggingface dataset:
effects of chi kung to improve the symptoms of menopause

Conditions: Quality of Life and Menopause

Summary: to analyze the effects of a chi kung exercise program in spanish menopausal women

this is a randomized clinical trial of single-blind with 2 arms (control group and experimental group), in which a pre-treatment-postest design has been used. the study will define two groups: a control group (cg) that will not be submitted to treatment, which will be evaluated in the pre and post phase of the study. participants assigned to this group will receive general advice on the positive effects of regular physical activity and will be given a guide to recommendations for promoting physical activity. an experimental group (ge) that after an initial evaluation will undergo a physical training program based on chi kung exercises. once the intervention is finished, it will be submitted to a final evaluation to see if there is a difference or not with the results obtained at the beginning.

Eligibility criteria:
inclusion criteria: * cessation of menstrual activity for twelve months or more. * being able to understand the instructions and exercise protocols of this project exclusion criteria: * contraindications for the performance of physical tests, cancer or serious illness, musculoskeletal and neurological diseases, taking of drugs that affect the central nervous system or antidepressants, or lack of will to participate in the study
comparison of il-8, fgf-1 and vegf levels in pulpal tissue, gcf and dentinal fluid samples of healthy, reversible and irreversible pulpitis diagnosed teeth

Conditions: Pulpitis; Pulp Inflammation; Healthy Pulp; Biomarkers; Reversible Pulpitis

Summary: this study will include 50 patients diagnosed with healthy, reversible and irreversible pulpitis. il-8, fgf-1 and vegf levels will be compared using pulpal tissue, gingival crevicular fluid, dentinal fluid samples collected from the teeth of these patients. first, the dos sample will be collected non-invasively using periopaper strips without local anesthesia. then, the caries will be cleaned by applying local anesthesia and rubber dam to the patient and a dentinal fluid sample will be collected noninvasively using pvdf membranes. in teeth with pulp exposure due to caries, the pulp tissue that needs to be removed will not be disposed of but collected as a sample. routine root canal treatment procedures will then continue and treatment of the teeth will be completed. the collected samples will be analyzed for il-8, fgf-1 and vegf levels by elisa test.


Eligibility criteria:
inclusion criteria: control group: * unrestored, caries-free vital teeth with healthy pulp * orthodontically indicated teeth for extraction * wisdom teeth indicated for extraction in terms of oral hygiene * teeth that require root canal treatment for prosthetic purposes reversible pulpitis group: * teeth that react mildly to cold, hot, sour or sweet stimuli * teeth with no history of spontaneous pain * teeth that respond to cold test and electric pulp test within normal limits * teeth that are not sensitive to chewing or percussion irreversible pulpitis group: * teeth with a history of continuous moderate or severe spontaneous pain * teeth sensitive to percussion * teeth without periapical pathology exclusion criteria: * patients requiring antibiotic prophylaxis. * patients with diabetes or haematological diseases. * patients who have used antibiotics or anti-inflammatory drugs in the last three weeks. * patients who are pregnant during treatment. * patients with intense plaque and tartar on their teeth, redness and bleeding in the gums. * patients with severe gingivitis, generalised periodontitis or periodontal pocket depth of more than 3 mm. * patients with no response to pulp sensitivity tests, presence of sinus tract, presence of periapical pathology on radiography. * teeth without pulp exposure after caries removal

Keywords: pulpal diagnosis vegf pulpitis fgf-1 il-8
risk factors of epistaxis recurrence in adults

Conditions: Epistaxis

Summary: we study all patients admitted to the emergency department in the institution between 01/2022 and 07/2023. the information about the recurrence of nose bleeding was searched on their medical file and by calling the patient to confirm ou get the information. thus, several potentiel risk factors were studied. the relation between recurrence and those factors were studied at first individually and then all the significant ones were analyzed with a multivarious statistical test.

we study all patients admitted to the emergency department in the institution between 01/2022 and 07/2023. the information about the recurrence of nose bleeding was searched on their medical file and by calling the patient to confirm ou get the information. thus, several potentiel risk factors were studied : oral anticoagulants, sex, inr, anti-platelets drugs, diabetes, obesity, arterial hypertension, heart failure, hemoglobin at the admission, history of chronic rhinosinusitis, appointment with an ent during the acute bleeding, sleep apnea, age, anatomic abnormality, recent surgery within 2 months, previous admission within 30 days in the emergency department, nasal trauma. the relation between recurrence and those factors were studied at first individually and then all the significant ones were analyzed with a multivarious statistical test. this study aim to provide a pronostic score of recurrence that can happen after the 3 fisrt weeks after the event. when a recurrence happens before 3 weeks, this was considered to be a non control of the bleeding episode. this score will be then tested on our cohort to evaluate specificity and sensibility.

Eligibility criteria:
inclusion criteria: * patient who is admitted at the emergency department between 01/2022 and 07/2023 for nose bleeding. * age over 18 yo exclusion criteria: * opposition to be included * patient who has not his willness to provide opposition to participate.opposition

Keywords: risk factors recurrent epistaxis
the efficacy of robot-assisted intelligent rehabilitation treatment in patients with aud

Conditions: Alcohol Use Disorder

Summary: we aimed to test the efficacy of robot-assisted intelligent rehabilitation treatment in patients with alcohol use disorders with a randomized controlled trial. specifically, the objective of this trial is to determine whether the robot-assisted intelligent rehabilitation treatment plus treatment as usual has greater efficacy than traditional therapy in the treatment of alcohol use disorders.

based on artificial intelligence technology, face recognition technology, and virtual reality technology to develop an available robot-assisted rehabilitation intelligent system. then, using this intelligent system as a new way of psychotherapy to provide treatment for patients with alcohol use disorders, and compare with traditional treatment to verify the efficacy and safety of the robot-assisted rehabilitation intelligent system in chinese patients with alcohol use disorders.

Eligibility criteria:
inclusion criteria: 1. between the ages of 18-55; 2. meeting dsm-5 criteria for alcohol use disorders; 3. withdrawing alcohol for less than 12 months; 4. ability to use computers; 5. signing informed consent; exclusion criteria: 1. having comorbidities of other neuropsychiatric diseases; 2. diseases that affect cognitive function, such as a history of head trauma, cerebrovascular disease, epilepsy, etc. 3. with a family history of mental illness 4. not familiar with computer operation, unable to complete assessment and treatment.
a phase ib study of azd5004 in chinese participants with overweight/obesity with or without type 2 diabetes mellitus

Conditions: Obesity or Overweight; Type 2 Diabetes

Summary: the purpose of this study is to evaluate the safety, tolerability, and pk of azd5004 compared with placebo in chinese participants with overweight/obesity with or without t2dm.

this is a phase ib, randomized, parallel-group, double-blind, placebo-controlled, multicentre, 2-arm treatment study to investigate the safety, tolerability, and pk of azd5004 compared with placebo in chinese male and female participants aged 18 to 74 years, who are overweight/obese with or without t2dm. the primary endpoints are incidence of aes, saes, daes, death, aesis, laboratory parameters, 12-lead ecg, and vital signs.

Eligibility criteria:
inclusion criteria: * aged 18 to 74 years inclusive at the time of signing the informed consent. * stable self-reported body weight for 3 months prior to screening. inclusion criteria for cohort a: - 27 kg/m2 ≤ bmi ≤ 35 kg/m2 and weigh at least 60 kg at screening. inclusion criteria for cohort b: * diagnosed with t2dm for at least 6 months prior to signing the informed consent. * hba1c value at screening of ≥ 7.0% and ≤ 10.5% * bmi of ≥ 24 kg/m2 at the screening visit. exclusion criteria: * history of, or any existing condition that influence the participant's ability to participate or affect the interpretation of the results of the study. * known clinically significant gastric emptying abnormality. * significant hepatic disease. * abnormal renal function. * history of acute pancreatitis and chronic pancreatitis, gallstones. * uncontrolled thyroid disease.
tranexamic acid to reduce bleeding in burn surgery

Conditions: Tranexamic Acid; Burns; Surgery; Wounds and Injuries

Summary: excision and grafting in burn patients can lead to severe blood loss. a preliminary study conducted in saint joseph saint luc hospital showed that the total median blood loss was 1412 ml (1). transfused patients had a total median blood loss of 2468 ml and an average number of 4 packed red blood cells (prbc) administered. among the various methods that help limit blood loss, tranexamic acid, which has been proved useful in traumatology and surgery, has not been sufficiently studied in burn patients. a preliminary study in 27 burned patients showed a reduction of blood loss with tranexamic acid (2). objective of tranburn study is to demonstrate that tranexamic acid help limit blood loss and reduces the use of blood products.

the first aim of the study is to demonstrate that tranexamic acid help limit blood loss and reduces the use of blood products. secondary objectives are to evaluate impact of tranexamic acid on mortality, success of skin grafts and occurrence of deep vein thrombosis or myocardial infarction.

Eligibility criteria:
inclusion criteria: * subjects undergoing burn excision surgery for standard of care purposes * male or female \>= 18 years of age * subject or subject's medical decision maker agrees to participate in this study and provides informed consent exclusion criteria: * subjects with a history of hypercoagulopathy, deep vein thrombosis (dvt), pulmonary embolism * renal impairment * subjects with known hypersensitivity to tranexamic acid * consecutive fibrinolytic states to coagulopathy * history of convulsions

Keywords: tranexamic acid burn surgery excision
virtual reality and occupational performance, satisfaction, and quality of life of older adults

Conditions: Aging

Summary: older adult participants will complete eight immersive virtual reality (vr) sessions with the researcher, within five weeks (no more than two sessions per week may be scheduled). the screening process and assessment measures are not included in the five weeks of virtual reality. sessions will consist of 30 minutes of use of the virtual reality goggles. during the virtual reality sessions, participants will select from a list of oculus go apps related to their self-identified occupational performance issues. participants are expected to complete the session while seated with the vr set secured on their head.

virtual reality (vr) may promote engagement in meaningful daily activities that is tailored to the individual's skill level, need, and significance to their individual context. there is limited research on measurable changes in perceived meaningful daily activities after utilizing immersive vr, specifically with a head mounted display. only in recent years have head-mounted displays become less expensive and more commercially available for research and patron purchase. at the low cost of $250, the device is within the reach of many older adult community centers for leisure and recreational use. the researchers will measure changes in occupational performance, occupational satisfaction, and quality of life for the older adult members of a community center, after eight immersive vr sessions. sessions will consist of 30 minutes of use of the virtual reality goggles. during the virtual reality sessions, participants will select from a list of oculus go apps related to their self-identified occupational performance issues. participants are expected to complete the session while seated with the vr set secured on their head.

Eligibility criteria:
inclusion criteria: 1. older adults aged 55+ that attend journey's way 2. members need to attend least twice a week exclusion criteria: 1. score of 17 or less on the moca 2. a self-report a history of any of the following: seizures, epilepsy, dizziness, vertigo, or motion sickness, any current contagious skin and eye conditions, experience sensitivity to light, have or use hearing aids, and a pacemaker and/or a defibrillator.

Keywords: older adults virtual reality quality of life occupation
study of lacosamide as an adjunctive drug treatment for epilepsy in patients with brain tumors

Conditions: Brain Tumor Related Epilepsy (BTRE)

Summary: this study is being conducted to find out whether lacosamide (a drug to treat epilepsy) is effective in routine clinical practice for patients with epilepsy caused by a brain tumor.


Eligibility criteria:
inclusion criteria: * patient has never been treated with lacosamide (lcm) prior to this non-interventional study (nis) or treatment with lcm for the first time started no earlier than 7 days prior to enrollment in this nis * the decision by the treating physician to prescribe lcm falls within current standard clinical practice, and the treatment decision is clearly separated from the decision to consider inclusion of the patient in the nis * a patient data consent form is signed and dated by the patient and/or by the parent(s) or legal representative * patient is a male or female ≥ 16 years of age * patient must have a diagnosis of brain tumor-related epilepsy (btre) secondary to low-grade glioma (world health organization grade 1 to 2 at time of enrollment) * patient has a retrospective baseline seizure frequency of at least 1 partial-onset seizure in the 8 weeks prior to visit 1 (enrollment/ baseline visit) * patient does not have a previous diagnosis of epilepsy before tumor onset * patient does not have brain metastases * patient has a karnofsky performance status scale index ≥ 60 % * patient is currently taking only 1-2 baseline anti-epileptic drugs (aeds) for epilepsy, other than lcm * patient has received a maximum of 4 different lifetime aeds ever before entering the nis exclusion criteria: * n/a

Keywords: epilepsy brain tumor lacosamide (lcm) anti-epileptic drugs (aeds)
free-living monitoring of parkinson's disease using smart objects

Conditions: Parkinson Disease

Summary: parkinson's disease, one of the most common neurodegenerative diseases of the central nervous system, presents motor symptoms, including tremor, rigidity, bradykinesia, and postural instability. assessments of patients with parkinson's disease are typically performed using clinical scales, compiled by the healthcare staff or by the patient. although commonly used in clinical practice, they have some limitations, including the low temporal resolution of the scales, the low granularity of the scores and the possible low inter- and intra-operator reliability. the recent development of digital technologies has led to the creation of iot (internet of things) devices capable of providing quantitative indicators, potentially useful for an accurate differential diagnosis, as well as for monitoring the effects of therapeutic interventions. the peculiarity of these systems is the ability to provide indicators not only during periodic visits to the clinic, but also the ability to remotely monitor the patient's daily life activities. in this scenario, this study wants to test the hypothesis that the iot devices like smart-ink pens and insoles are usable options for monitoring patients with parkinson's disease.


Eligibility criteria:
inclusion criteria: * adult individuls * cognitive impairments * ability to independently sign the written informed consent exclusion criteria: * unstable pharmacological treatment for parkinson's disease during the study * previous history of major neurological, vascular, musculoskeletal disorders
postoperative pain after pulpectomy of primary molars

Conditions: Postoperative Pain

Summary: testing postopertive pain after pulpectomy of primary molars with endoflas using modified wong-baker scale of pain.

testing postopertive pain after pulpectomy of primary molars with endoflas using lentilospiral files and pressure seringe by using modified wong-baker scale of pain.

Eligibility criteria:
inclusion criteria: * the current study will include children who meet the following clinical and radiographic criteria: 3.1a.clinical: 1. 5-7-year old children categorized as class i or ii according to american society of anaesthesiologists (asa) scale. 2. children rated as no.3 or 4 in frankel behavior rating scale (fbrs). 3. presence of at least one primary molar with deep carious lesion. 4. asymptomatic necrotic molars confirmed by the absence of bleeding on opening of the pulp chamber. 3.1b. radiographic: 1. extensive caries approaching to the pulp. 2. presence of at least two-thirds of root length. exclusion criteria: * a child's tooth with any of the following criteria: 3.2a. clinical findings: 1. history of spontaneous unprovoked toothache. 2. extensive crown destruction that preclude coronal restoration. 3. presence of adjacent or opposing tooth with deep carious lesion "in the same side". 4. history of administering analgesics 12 hours before tooth obturation. 3.2b. radiographic findings: 1. presence of a large furcation or periapical radiolucency approximating the succedaneous tooth. 2. presence of pathological internal/external root resorption. 3. absence of underlying permanent successor.
the effect of diabetes education digital games and video animation on quality of life

Conditions: Type 1 Diabetes Mellitus

Summary: this research will be conducted to evaluate the effect of digital game and video animation-based diabetes education on the quality of life of children with type 1 diabetes. hba1c, diabetes knowledge and quality of life scale in children with diabetes (pedsql 3.0) score will be taken into consideration when evaluating the quality of life of children with type 1 diabetes.

this research was conducted to examine the effects of diabetes education given to children with type 1 diabetes mellitus with digital game and video animation on quality of life and metabolic control. the study is a single-blind, randomized controlled trial. it was conducted with a total of 55 children with type 1 diabetes mellitus, including the experimental (n=27) and control group (n=28). diabetes education was given to the experimental group with digital games and video animations. data were collected before the training, at the 3rd and 6th months after the training. research data were collected with "descriptive information form", "quality of life scale in children with diabetes mellitus" and "metabolic control parameters follow-up form". children in the control group received routine outpatient examination/check-up and diabetes education by a diabetes nurse. children in the intervention group were given digital game and video animation-based training, as well as routine outpatient examination/check-up and training given by a diabetes nurse.

Eligibility criteria:
inclusion criteria: * children's willingness to participate in the research (written consent of their parents, verbal consent was obtained from the children), * being between the ages of 8-12, * having been diagnosed with type 1 diabetes mellitus at least 1 year ago * to have regular follow-ups, * no communication disability (speech, hearing, vision problems) * it means having a device (computer) with internet connection at home and being able to use it. exclusion criteria: * having any chronic disease together with diabetes, * using an insulin pump

Keywords: diabetes education digital game video animation
external anal sphincter fatigability

Conditions: External Anal Sphincter Fatigability

Summary: external anal sphincter is a skeletal muscle under voluntary control. as described in previous studies, it is mainly composed of type 1 fibers. fatigability is a concept which has been studied and described many times in skeletal limbs muscles. two types of fatigue are described, peripheral of central fatigue. fatigue can been physiologic but also pathologic (due to an affection of the muscle, the peripheral nervous system or the central nervous system). many tools have been used to measure muscle fatigability (direct strength measure on isometric contraction, electromyography, echography, oxymetry...). besides many fatiguing methods have been developed for every each muscle depending on its histological structure. anal sphincter fatigability has already been described in few manometric studies with particularly 2 measures: fatigue rate and fatigue rate index. moreover, no fatiguing protocol has been standardized to study it. the primary aim of this study is to define a fatiguing protocol for external anal sphincter in order to study it in further studies. secondary aims are to assess electromyography as a tool for measuring this fatigability and finally to assess the link between anal sphincter fatigability and symptoms reported by patients. patients over 18 years old, consulting for an anorectal manometry with a voluntary command on the external anal sphincter are included. history and treatment, height, weight, sex, age, fatigue impact scale, digestive symptoms with neurologic bowel disorders score and wexner scale, urinary tract symptoms with urinary symptom profile (usp) score and electromyography (root mean square (rms) and mean power frequency (mpf)) and manometric data (contraction peak, fatigue rate, fatigue rate index) were recorded. the fatiguing protocol consists in 10 sustained external anal sphincter contractions with maximal voluntary contraction of 20 seconds followed by 10 seconds of resting. a training contraction is made before the fatiguing protocol. at the end of the protocol, patients undergo a classical anorectal manometry. primary outcome is the difference on root mean square in electromyography between the first and the last fatiguing contraction. secondary outcomes were mean power frequency and manometric data (i.e. fatigue rate index (fri), fatigue rate (fr), contraction peak) influence of age, sex, symptoms, pathologies, weight on fatigability will be studied in a second analysis


Eligibility criteria:
inclusion criteria: * over 18 years old * voluntary command on external anal sphincter contraction during physical examination * anorectal disorders exclusion criteria: * inability to understand simple orders

Keywords: anal canal external anal sphincter muscle fatigue electromyography anorectal manometry