Kornimate/medical-research-clean huggingface dataset:
study on the influence of fluoroscopy in the diagnosis of peripheral lung lesions with endobronchial ultrasound guidance

Conditions: Peripheral Pulmonary Lesions

Summary: the purpose of this study is to determine whether the use of fluoroscopy improves the diagnostic yield of peripheral pulmonary lesions' biopsy guided by radial endobronchial ultrasound (with the use of a guide sheath).

see above

Eligibility criteria:
inclusion criteria: * consecutive patients referred for the bronchoscopic diagnosis of peripheral pulmonary lesions at the institut universitaire de cardiologie et de pneumologie de québec(not visible endobronchially) * adults over the age of 18 exclusion criteria: * therapeutic anticoagulation * antiplatelet therapy other than aspirin * known hemorrhagic diathesis * acute respiratory failure * pregnancy * inability to provide informed consent

Keywords: radial endobronchial ultrasound peripheral lung lesion fluoroscopy lung cancer
pulmonary rehabilitation in chronic obstructive pulmonary disease (copd): the development and feasibility of an education package

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of this study is to assess the feasibility and acceptability of the revised living well with copd programme (lwwcopd for pulmonary rehabilitation) when used to deliver the education component of pulmonary rehabilitation.

there is limited guidance on what should be included in the education component of pulmonary rehabilitation. international guidelines for copd and pulmonary rehabilitation suggest numerous topics but do not provide specific information relating to the principal topics and how these should be delivered (bts 2001, nice 2004, ats/ers 2006). recently this research team conducted focus groups of patients with copd and established from their perspective the important education topics that should be covered in pulmonary rehabilitation, along with information on how these should be delivered (wilson, o'neill et al. 2008). the living well with copd (lwwcopd) programme mostly includes these topics (bourbeau, julien et al. 2003). lwwcopd, which is based on bandura's self-efficacy theory, has been shown to significantly reduce healthcare utilisation and improve quality of life (bourbeau, julien et al. 2003, bandura 1986). with modification and reformatting, the lwwcopd programme could be delivered within the structure of pulmonary rehabilitation. although the lwwcopd programme has been previously validated, it is important that the revised version is assessed for feasibility within the context of pulmonary rehabilitation. the practicality of delivering the programme and its acceptance by healthcare providers and patients should be assessed. therefore, this study will involve a process evaluation to assess the feasibility and acceptability of using the revised lwwcopd programme (lwwcopd for pulmonary rehabilitation) to deliver the education component of pulmonary rehabilitation in northern ireland.

Eligibility criteria:
inclusion criteria: participants * clinical diagnosis of copd. * good understanding of written english in order to be able to provide accurate feedback on the patient information booklet and material used to facilitate the education sessions (as reported by the individual patient). * eligible for pulmonary rehabilitation health professionals * involved in the delivery of education sessions during pulmonary rehabilitation exclusion criteria: participants * unable to safely partake in pulmonary rehabilitation (e.g. unstable angina, some musculoskeletal conditions). * unable to comprehend or follow instructions (e.g. dementia).

Keywords: pulmonary rehabilitation
pilot study: lactoferrin for prevention of neonatal sepsis

Conditions: Sepsis

Summary: we will test the hypothesis that bovine lactoferrin supplementation prevents serious infections in preterm infants. we will conduct a randomized placebo-controlled double blind study in 190 premature infants \<2500 gm in 5 neonatal intermediate and intensive care units in lima, peru to determine whether bovine lactoferrin prevents the first episode of late-onset sepsis.

lactoferrin is an iron chelating protein with multiple physiological functions (anti-microbial, anti-inflammatory and immunomodulatory) and is one of the most important proteins present in mammalian milk. we hypothesize that lactoferrin as an oral supplement given daily to low birth weight will improve their health by mimicking their protective role in milk. there is extensive literature showing in vitro and in animal models the benefits of lactoferrin. however, there are few clinical trials designed to translate this knowledge into patient care. we will conduct a pilot randomized, double-blinded placebo-controlled trial comparing daily supplementation with bovine lactoferrin versus placebo in neonates to reduce the incidence of sepsis in the first month of life. we will enroll 190 neonates with a birth weight less than 2,500 g, younger than 3 days of age in the neonatal intensive care unit of 5 pediatric hospitals in lima, after informed consent of both parents. infants will be followed in the hospital until death or discharge and then at home up to 1 month of age. bovine lactoferrin will be used in this trial (200 mg/kg per day). although bovine and human lactoferrin are not identical, their bioactivity is quite comparable. maltodextrin (an inert sugar) will be used for controls. the primary study outcome will be the number of first late-onset sepsis episodes (occurring \>72h after birth with isolation of any pathogen in blood or cerebrospinal fluid).

Eligibility criteria:
inclusion criteria: 1. neonates with a birth weight between 500g and 2500g 2. neonates born in, or referred to the neonatal intermediate and intensive care units of one of the participating hospitals in the first 72 hours of life. exclusion criteria: 1. neonates with underlying gastrointestinal problems that prevent oral intake. 2. neonates with predisposing conditions that profoundly affect growth and development (chromosomal abnormalities, structural brain anomalies, severe congenital abnormalities) 3. neonates with a family background of cow milk allergy 4. neonates that, according to the investigator criteria, will not have the chance to complete the subsequent study visits (patients that before one month old would not be living in lima). 5. neonates whose parents decline to participate.

Keywords: lactoferrin sepsis neonates prevention infections
right ventricular function in obstructive sleep apnea

Conditions: Sleep Apnea, Obstructive

Summary: the purpose of this study is to determine the structural and functional cardiac alterations in obstructive sleep apne (osa) independent from systemic and pulmonary arterial hypertension and their correlation to the severity of osa.

many risk factors for osa, such as male gender, obesity, and increasing age are the same as for cardiovascular diseases. this fact makes it more difficult to establish a causal relationship between osa and cardiovascular diseases. the relationship between osa and right ventricular (rv) function is controversial. rv dysfunction may be a result of chronic intermittent hypoxia and hypercapnia during apneic episodes. it may also occur secondary to left ventricular dysfunction as a result of increased afterload and sympathetic activity which causes secondary hypertension. as systemic hypertension is one of the most accompanying and contributing factors in osa along with obesity, we tried to compare the effects of newly diagnosed osa on rv function with an age and body mass index- matched control group.

Eligibility criteria:
inclusion criteria: for osa patients (group1) * apnea hypopnea index equal or more than 15 * epworth sleepiness scale equal or more than 10 * no previous treatment for osa exclusion criteria: * age \< 18 years * known hypertension, or 24-hour mean blood pressure of 135 and/or 85 mmhg or more * mean pulmonary artery pressure \> 25 mmhg * diabetes mellitus * left ventricular ejection fraction \< 60% * moderate to severe valvular disease * cardiomyopathy * renal failure * coronary artery disease * obstructive or restrictive lung disease demonstrated on pulmonary function test * connective-tissue or chronic thromboembolic disease * pericardial disease * cancer and/or other important comorbidities with an expected survival \< 2 years * suboptimal echocardiographic images for measurements
effect of quality improvement tools in congestive heart failure (chf)

Conditions: Congestive Heart Failure

Summary: hypothesis: quality improvement tools like "heart failure discharge checklist" which emphasizes on proper education to patients, ensure appropriate dose titration and counselling improve outcome in congestive heart failure (chf).


Eligibility criteria:
inclusion criteria: * patients admitted to sjmo with principal diagnosis of acute decompensated heart failure exclusion criteria: * age less than 18 years * pregnant women

Keywords: quality improvement
evaluation of sun's scoring system use in post-pancraticodoudenectomy pancreatic fistula

Conditions: Risk Scoring System for Prediction of Pancreatic Fistula Post PD

Summary: evaluation of sun scoring system for predication of pancreatic fistula after pancreaticoduodenectomy to facilitate timely intervention after pancreaticoduodenectomy.

pancreaticoduodenectomy is the only option curative intended in the treatment of resectable pancreatic ductal adenocarcinomas, duodenal carcinoma, ampullary carcinoma, lower common bile duct cholangiocarcinoma,. it is still associated with very high morbidity and mortality. \[1\]. pancreatic cancer ranks as the seventh leading cause of cancer-related death worldwide, and the fourth among other cancers\[2,3\]. pancreatic fistula(pf) is one of the most important complications after pancreaticoduodenectomy, with an incidence of about 10% to 28%.\[4\].there are multiple risk factors for the predication of development of pancreatic fistula after pancreaticoduodenectomy which include soft gland texture, non-pancreatic cancer non-chronic pancreatitis pathology, small pancreatic duct diameter (\ 1000 ml) , excess intraoperative fluid administration and increased pancreatic parenchymal remnant volume \[5,6,7\]. other reported risk factors as increased body mass index (bmi), poor preoperative nutrition, and male gender which preoperative may lead to pancreatic fistula \[8.9\]. recent studies are deficient in evaluation and predication of pancreatic fistula . so the interest of our study to evaluate and predicate the risk factors and management of pancreatic fistula after pancreaticoduodenectomy .

Eligibility criteria:
inclusion criteria: * all the cases indicated for pancreaticoduedenectomy with : 1. age less than 70 years. 2. resectable tumour, 3. fitness patients exclusion criteria: * 1_patients with jaundice with serum bilirubin above 200mml/dl. 2_patients with bleeding tendency until corrected. 3_patients with advanced and metastatic malignancy. 4_patients with cardiopulmonary diseases.
effect of exercise on heart function in healthy elderly people

Conditions: Diastolic Dysfunction

Summary: the purpose of this study is to determine the effect of aerobic interval training on left- and right ventricular diastolic- and systolic function on healthy, sedate people over 70 years. the old sedate cohort will be compared to young, sedate subjects also performing aerobic interval training and old master athletes without intervention.

aging is associated with a reduced diastolic and systolic function of the heart. earlier studies have shown that physical exercise can improve both systolic and diastolic function. however the impact on age-related cardiac function is to some extent conflicting. the use of different training intensities will impact on the cardiac result. we have in earlier studies shown aerobic interval training at 90 % of maximal heart rate (4x4 minutes) to have more impact on cardiac function, endothelial function and maximal oxygen uptake compared to moderate intensity. to our knowledge the effect of aerobic interval training on cardiac function has not been studied in an old, sedate group before.

Eligibility criteria:
inclusion criteria: * over 70 years, healthy * not exercising more than twice per week exclusion criteria: * chronic illness * chronic use of any medication * regular smoking * metabolic or cardiovascular diseases

Keywords: aging diastolic dysfunction systolic function exercise echocardiography tissue doppler imaging cardiac function
second line therapy for the cure of helicobacter pylori (h. pylori) infection

Conditions: Helicobacter Infections; Gastritis; Gastric Ulcer; Duodenal Ulcer

Summary: proton pump inhibitors (ppis) are mainly metabolized in the liver by cyp2c19, one of the cytochrome p450 isoenzymes, which shows a genetic polymorphism associated with enzyme activities. the most essential role of a ppi in h. pylori eradication therapy is to make antibiotics more stable and bioavailable in the stomach by raising intragastric ph to neutral levels. most patients who have failed in the eradication of h. pylori infection by triple therapy with a ppi, amoxicillin (ampc) and clarithromycin (cam) at standard doses have extensive metabolizer (em) genotypes of cyp2c19 and/or are infected with cam-resistant strains of h. pylori. four-times daily dosing of a ppi could achieve complete gastric acid inhibition. dual therapy with 4-times daily dosing of a ppi and ampc could yield sufficient re-eradication rates in patients with em genotype of cyp2c19. metronidazole (mnz)-based re-eradication therapy, such as triple ppi/ampc/mnz therapy, also achieved high eradication rates and has been recommended as the second line therapy in japan. but carcinogenic actions of mnz have been unclear. the purpose of this study is to compare the re-eradication rates of h. pylori infection by the dual high-dose ppi/ampc therapy and triple ppi/ampc/mnz therapy, and to validate the efficacies of these re-eradication regimens as second line eradication therapies.


Eligibility criteria:
inclusion criteria: * patients with h. pylori infection exclusion criteria: * patients without h. pylori infection

Keywords: h. pylori infection
the effects of hypobaria vs hypoxia on cerebral functions.

Conditions: Cerebral Hypoxia

Summary: the investigators will investigate the effect of hypobaria and hypoxia on physiological responses such as: oxygen saturation, heart rate, cerebral blood flow, cerebral oxygenation, brain's activity and concentration performance.

the main goal of this project is to investigate how hypoxia affects cognitive functions. the klt-r test asses the concentration level of a person. subjects will do this test at different simulated altitude level in the hypobaric chamber at the fai in dübendorf. investigators' first hypothesis is that concentration level will be altered by hypoxia. the higher altitude the subjects are, the more the concentration would be altered. klt-r performance would be impaired by hypoxia compare to sea level performance. the primary endpoint of this project is to investigate how klt-r performance is affected by the different hypoxic conditions. klt-r test will be passed nine times in total during the test visit. there will be a pre-test; a test at each of the conditions (3000m hh, 5500m hh, 5500m nh and 5500m hn); between each condition at sea level (to have a new baseline before each condition) and a post-test at the end of the protocol. to avoid influence of fatigue, all conditions will be randomized. the second endpoint of this study is how the brain electrical activity is modulated by hypoxia. micro-states also will be measure during hypobaric hypoxia conditions (3000m hh and 5500m hh).

Eligibility criteria:
inclusion criteria: * no history of flight sickness * no relevant medical diseases * age 18 - 40 years * written consent acceptance exclusion criteria: * known pathologies * relevant medical disorders * drug addiction * anemia or poor health * people who have already had problems with elevation

Keywords: hypoxia brain cerebral vaso-reactivity eeg concentration performance cerebral oxygenation cerebral blood-flow heart rate variability
d-stress baltimore: school-based mindfulness instruction

Conditions: Coping; Stress Disorders, Post-Traumatic; Mental Health Wellness 1

Summary: effective strategies to ameliorate the negative effects of stressful urban living are greatly needed. d-stress baltimore (dsb) is an evidence-based mindfulness-based instructional program of stress-reduction techniques, found to reduce mental health problems across many adult populations. the investigators propose to conduct a randomized controlled trial of the 12-week school-based dsb program compared with a 12-week school-based health education control program at elev8 schools among 5th-8th graders to assess if dsb program is beneficial for mental health and behavioral problems among public middle-school students.

urban youth in baltimore city are under significant and inevitable stresses, including violent neighborhoods, failing schools, and interpersonal conflict. effective strategies to ameliorate the negative effects of stressful urban living are greatly needed. d-stress baltimore (dsb) is an evidence-based mindfulness-based instructional program of stress-reduction techniques which has been found to be beneficial for adults in decreasing anxiety and depression, improving positive emotions, and reducing anger. the investigators propose to conduct a randomized controlled trial of the 12-week school-based dsb program compared with a 12-week school-based health education control program at elev8 schools among 5th-8th graders. the investigators hypothesize that the d-stress baltimore program will reduce negative emotions, including hostility, and improve coping.

Eligibility criteria:
inclusion criteria: * 5th - 8th graders in select baltimore city schools exclusion criteria: * n/a

Keywords: mindfulness intervention african american youth stress poverty
a multicenter assessment of a spontaneous preterm birth risk predictor

Conditions: Preterm Birth

Summary: prospective multicenter observational study to further develop and validate a preterm birth risk predictor, using a preterm cutoff at 37 0/7 weeks gestation and at 35 0/7 weeks gestation. a single maternal peripheral blood sample will be collected for analysis. data related to potential risk factors for preterm birth will be obtained through maternal interview and review of medical records. subjects will be followed through the delivery process to assess the course of pregnancy, labor, and to document any related maternal complications. neonatal outcomes will be gathered from the medical record for up to 28 days of life or discharge, whichever occurs first.


Eligibility criteria:
inclusion criteria: * subject is 18 years of age or older * subject has singleton gestation * subject is able to provide consent * gestational age is confirmed by a documented crown rump length on an ultrasound performed at the study site within 6 0/7 weeks and 13 6/7 weeks gestation (first trimester) * subject has no signs and/or symptoms of preterm labor and has intact membranes * investigator believes subject is willing to comply with study visits and procedures * investigator believes the subject's delivery data will be available within 15 business days from delivery, and neonatal data will be available for data collection purposes within 15 business days from discharge exclusion criteria: * the subject has a planned cesarean section or induction of labor prior to 370/7 weeks of gestation * the subject has a planned cerclage placement for the current pregnancy * there is a known or suspected fetal anomaly or chromosomal abnormality * the subject has had a blood transfusion during the current pregnancy * the subject has known elevated bilirubin levels (hyperbilirubinemia) * the subject has taken or plans to take any of the following medications during the current pregnancy: * progesterone or progesterone-derivative medication after 13 6/7 weeks gestation * enoxaparin, heparin, heparin sodium, low molecular weight heparin after first day of last menstrual period * the subject has participated in, or plans to participate in, an interventional treatment study during the current pregnancy * the current pregnancy was previously a multiple gestation that is now a single fetus due to reduction, vanishing twin, etc.

Keywords: proteomics pregnancy biomarkers preterm birth
a real-life study to learn about the use and effects of the cdk4/6 inhibitors in canadian patients with breast cancer.

Conditions: Breast Cancer

Summary: cdk4/6 inhibitors are approved medicines indicated for the treatment of a kind of advanced/metastatic breast cancer, called hormone receptors positive (hr+)/ human epidermal growth factor receptor 2 negative (her2-) disease. they are given orally in combination with hormonal therapies. the purpose of this study is to better understand how the cdk4/6 inhibitors combinations are used in real-life conditions and their clinical impact for the treatment of canadian patients affected by (hr+)/ (her2-) advanced breast cancer (abc) or metastatic breast cancer (mbc). female patients aged 18 years old or more presenting the following conditions will be selected for the study: * hr+/her2- breast cancer diagnosis with confirmed metastatic or advanced disease * diagnosis of abc/mbc between 01 january 2016 and 01 july 2021 * treatment with cdk4/6 inhibitor information will be collected from one single canadian institution, on each selected real-life patient treated with cdk4/6 inhibitors.


Eligibility criteria:
inclusion criteria: * hr+/her2- breast cancer diagnosis with confirmed metastatic or advanced disease * diagnosed with abc/mbc between 01 jan 2016 and 01 july 2021 * treatment with cdk4/6 inhibitor exclusion criteria: * patient does not have abc/mbc * patient has indicated hr- or her2+ status * patient received a cdk4/6i as part of a clinical trial

Keywords: metastatic breast cancer advanced breast cancer hr+/her2-
the effects of mental practice combined with proprioceptive neuromuscular facilitation on muscle strength of upper limb and hand grip

Conditions: Motor Activity; Physical Activity; Neuromuscu

Summary: influence of mental practice and proprioceptive neuromuscular facilitation on muscle strength of upper limb and hand grip will be measured in 30 to 50 healthy students with right dominant hand, their age will be ranged from 18 to 26 years old. subjects will randomly assigned to either proprioceptive neuromuscular facilitation (pnf) group or proprioceptive neuromuscular facilitation with mental practice (pnfmp) group.

pnf group: 15 - 25 individuals, these subjects will receive only pnf training. pnfmp: 15 individuals, these subjects will receive pnf training with mp. training program will be conducted for every group for 5 weeks with 3 sessions x 30 min per week. electromyography (emg) device will be used to measure the electrical activity of muscles using surface electrodes. hydraulic hand dynamometer will be used to measure hand grip strength.

Eligibility criteria:
inclusion criteria: 1. the participant will be right-handed. 2. previously untrained subjects. 3. absence of a prior injury of the hand or arm exclusion criteria: 1. history of a neurological disease. 2. history of musculoskeletal injury of upper limb. 3. unstable medical condition