Kornimate/medical-research-clean huggingface dataset:
genetic variability and biomarkers in children with acute lung injury

Conditions: Acute Respiratory Distress Syndrome; Acute Lung Injury

Summary: acute lung injury (ali) and the more severe acute respiratory distress syndrome (ards) are a significant problem in pediatric intensive care units, affecting up to 16 of every 1000 children admitted to these units. these disorders carry with them high mortality rates as well as numerous long-term effects for the surviving children. as the effects of these diseases have significant social and economic ramifications for affected children and their families, research on the development of ali/ards could significantly change how physicians understand the disease and treat patients. there are a wide range of problems which make certain picu patients more likely to develop either ali or ards. this research aims to determine which of these children are at the greatest risk for ali/ards by examining differences in plasma biomarkers and in dna of a large number of picu patients. we are hypothesizing that significant differences in the level of specific plasma biomarkers or in the frequency of specific dna variants exist in children who develop ali/ards.


Eligibility criteria:
inclusion criteria: * consecutive intubated pediatric patients (≥ 2 weeks of age and ≥ 42 weeks corrected gestational age and ≤ 18 years of age) supported on mechanical ventilation for acute pulmonary parenchymal disease enrolled in the restore study. exclusion criteria: * intubated and mechanically ventilated for immediate post-operative care and stabilization * cyanotic heart disease with unrepaired or palliated right to left intracardiac shunt * history of single ventricle at any stage of repair * congenital diaphragmatic hernia or paralysis * primary pulmonary hypertension * critical airway (e.g., post laryngotracheal construction) or anatomical obstruction of the lower airway (e.g., mediastinal mass) * ventilator dependent (including noninvasive) on picu admission (chronic assisted ventilation) * neuromuscular respiratory failure * spinal cord injury above the lumbar region * pain managed by patient controlled analgesia (pca) or epidural catheter * family/medical team has decided not to provide full support (patient treatment considered futile) * enrolled in any other sedation clinical trial concurrently or within the last 30 days * known allergy to any of the study medications

Keywords: acute lung injury acute respiratory distress syndrome genetic variability plasma biomarkers pediatrics
vitamin d deficiency and placental calcification in low-risk obstetric population - are they related?

Conditions: Vitamin D Deficiency

Summary: maternal vitamin d deficiency has been suggested to influence fetal and neonatal health. the role of placenta in vitamin d regulation is known but alteration of vitamin d levels at placental pathologies is unknown. placental calcification is usually thought to be a physiological aging process. nevertheless, it can be a pathological change resulting from the effects of environmental factors on the placenta. the aim of the investigators study was to evaluate the relationship between placental calcification and maternal and cord blood 25-hydroxyvitamin-d3 \[25(oh)d\] and calcium concentrations in low-risk obstetric population at term and their consequences.

vitamin d deficiency is a public health problem prevalent throughout the world. low blood 25-hydroxyvitamin d3 ( 25ohd ) level was found to be associated with preeclampsia, gestational diabetes, infectious diseases, decrease in fetal bone mineralization, and increase in fetal respiratory infections and infant wheezing \[1\]. requirement of vitamin d is primarily met by the exposure of skin to sun and secondarily by intake of food. the provision of vitamin d from the skin depends upon melanin pigment, the use of sun screens, age, dressing style and seasonal changes \[1\]. placenta plays an important role in vitamin d metabolism during pregnancy and some independent risk factors increasing the risk of placental dysfunction at fetomaternal interface also influence vitamin d metabolism \[2,3\]. nevertheless, there can be a pathological change resulting from the effects of environmental factors on the placenta .

Eligibility criteria:
inclusion criteria: * term pregnancy exclusion criteria: * foreknown systemic diseases, multiple pregnancy, smoking cigarettes, receiving vitamin d or calcium supplementation.

Keywords: calcium vitamin d placental calcification.
a prospective observational study to evaluate the quality of life and the costs in a real life setting in patients who are treated with 90y-zevalin

Conditions: Lymphoma, Follicular; Non-Hodgkin Lymphoma

Summary: the objective of this study is to compare hematological toxicity, costs, health-related quality of life (hr-qol) and outcomes observed in real life in the belgian non-hodgkin lymphoma (nhl) population receiving 90y-zevalin, with model-predicted data at reimbursement on the basis of a clinical trial in heavily pre-treated nhl.


Eligibility criteria:
inclusion criteria: * advanced cancer of the lymph nodes of follicular type at study inclusion * the patient has relapsed or has refractory disease, after previous treatment with rituximab * treating physician has decided to treat the patient with a 90y-zevalin regimen * the patient is \>= 18 years of age * patient has given informed consent exclusion criteria: * patient is unwilling or unable to give informed consent * patient is participating in another clinical trial

Keywords: quality of life, health care costs
cryotherapy vs. leep to treat cervical intraepithelial neoplasia (cin) 2/3 among hiv-positive women

Conditions: Cervical Intraepithelial Neoplasia

Summary: the purpose of this study is to compare the rate of recurrence of cervical intraepithelial neoplasia among hiv-positive women receiving cryotherapy versus leep over 2 years of follow-up and to compare the shedding of hiv-1 from the cervix between hiv-positive women receiving cryotherapy versus leep over 3 weeks of follow-up.

the recent scale-up of antiretroviral treatment programs in resource-limited settings provides an unprecedented opportunity to implement a comprehensive cervical cancer screening and treatment program for women who, by virtue of having hiv, are at significant risk for cervical disease. unfortunately, even if screening is offered free of charge to millions of women living with hiv, it is unclear which treatment modality for pre-cancerous cervical lesions will be most effective since hiv appears to affect outcomes of treatment by increasing the recurrence and severity of cervical disease. cervical treatment may also increase shedding of hiv from the cervix which may put discordant couples at risk and possibly spread hiv more widely. this study proposes to randomize hiv-positive women with cervical intraepithelial neoplasia grade 2 and 3 (cin 2 and 3) to cryotherapy vs. loop electrosurgical excision procedure (leep) and measure the recurrence of cervical disease in each group over 2-years of follow-up as well as hiv shedding from the cervix for 6 weeks after treatment. our hypothesis is that compared to cryotherapy, leep is significantly more likely to prevent recurrence of cervical lesions over 2 years of follow-up and less likely to cause shedding of hiv-1 from the cervix over 3 weeks of follow-up.

Eligibility criteria:
inclusion criteria: * hiv positive receiving care at the coptic hope center * not pregnant by clinical examination or history * have an intact cervix * have not received prior cervical treatment * do not have a history of a bleeding disorder * are above 18 years of age exclusion criteria: * hiv-negative * male * below 18 years of age * pregnant by clinical examination or history * post-hysterectomy * post-cervical cancer treatment.
comparative study between level i and level ii temporomandibular joint arthroscopy in wilkes stage iii patients

Conditions: Temporomandibular Joint Dysfunction Syndrome

Summary: temporomandibular joint dysfunction (tmjd) represents a common health problem. its prevalence is nearly 31% in adults and 11% in adolescence, more common in females. aetiologies of tmjd are multifactorial and can be attributed to both physical and psycho-social factors. internal derangement of the temporomandibular joint (tmj) is the most frequent disorder; with anterior disc displacement is the most common form. wilkes has classified internal derangement into five stages; patients with stage iii usually present with limited mouth opening, joint pain and deviation of jaw upon opening to the affected side. mri is considered the gold standard for diagnosis. treatment of tmjd include non-surgical and surgical methods. non-surgical treatment includes instructions, pharmacotherapy, physiotherapy and occlusal splints; while surgical interventions include minimally invasive procedures (arthroscopy and arthrocentesis) and open joint surgery

arthroscopy of tmj was first introduced by ohnishi in 1975. there are three different levels of tmj arthroscopy. level i, single puncture arthroscopy, it allows lysis of adhesions in the upper joint compartment and lavage of the joint space and the inflammatory products. level ii is done by double puncture and it enables to perform maneuvers such as lateral pterygoid myotomy and ablation of the retrodiscal tissue. operative devices including arthroscopic instruments, nd-yag and holmium laser, and the high-frequency wave system (coblation) is very useful for tissue coagulation and cutting. both levels enabled getting joint mobilization and significant pain reduction. level iii (arthroscopic discopexy), it needs customized special instruments.

Eligibility criteria:
inclusion criteria: * wilkes stage iii patients exclusion criteria: * previous tmj surgery
message framing on recruiting rh-d negative blood donors

Conditions: Blood Donation

Summary: rh negative blood group is a rare blood group in china, as it only accounts for 0.3-0.4 percent of the han population. therefore, low inventory is often found in blood collection and supply agencies in many regions in china. on july 22, 2020 blood stockpile of o-negative and a-negative in guangzhou blood center reached the warning line, and we took measures for emergency recruitment. o-negative and a-negative blood donors whose last donation dates were between january 1, 2018 and december 31, 2019 were identified and randomly assigned to four groups. three different recruitment text messages were send three groups. we observed the re-donation rates among four groups within one week.


Eligibility criteria:
inclusion criteria: - o and a rh- negative blood donors last donations were between january 1, 2018 and december 31, 2019 exclusion criteria: - with an obviously invalid phone number serological results of the last donation were positive
anti-inflammatory effects of enriched enteral nutrition during human experimental endotoxemia

Conditions: Endotoxemia

Summary: during sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death. ideally, the inflammatory response is modulated leading to both adequate protection to invading pathogens as well as limitation of an exuberant immune response. in the last years, experimental evidence has been accumulating that enteral administration of lipid-enriched nutrition attenuates inflammation and preserves organ integrity in several inflammatory models. the current study investigates the immune-modulating potential of enriched enteral nutrition in a human setting of experimental endotoxemia.


Eligibility criteria:
inclusion criteria: * age ≥ 18 and ≤ 35 yrs * male * written informed consent * non-smoking exclusion criteria: * use of any medication (e.g. nsaid's, antibiotics, gastrointestinal motility altering medicine, corticosteroids) * smoking in the past year * history, signs or symptoms of cardiovascular disease * (family; first degree) history of cerebrovascular disease * previous vagal collapse * hypertension (defined as rr systolic \> 160 or rr diastolic \> 90) * hypotension (defined as rr systolic \< 100 or rr diastolic \< 50) * renal impairment (defined as plasma creatinin \>120 μmol/l) * liver enzyme abnormalities ( asat \> 60 u/l, alat \> 75 u/l, gamma-gt \> 60 u/l) * positive hepatitis serology * positive hiv test * allergy to milk and/or soy proteins

Keywords: enteral nutrition endotoxemia innate immunity nutritional anti-inflammatory pathway intestinal damage
culturally adapted icbt for arabic-speaking refugee and migrant youth with common mental health problems

Conditions: Depressive Symptoms; Anxiety; Insomnia; Grief; Psychological Trauma; Resilience; Stress; Marital Relationship; Psychological Well-Being

Summary: the aim of the current study is to explore whether culturally adapted internet-based cognitive behavioral therapy is effective in reducing the symptoms of various common mental health problems among arabic-speaking refugee and migrant youth. we hypothesize that the symptoms of the psychological problems will significantly be reduced among youth who will receive icbt compared to youth in the control group.


Eligibility criteria:
inclusion criteria: * between the ages of 15 and 29. * a score above the cut-off 1.75 on hscl-25 * has a refugee or migrant background * has a good and stable internet connection * has access to a computer, a tablet or a smartphone * is fluent in reading and writing arabic * has the ability to dedicate time to take part in the intervention for 6-10 weeks. exclusion criteria: * is suffering from a severe mental illness, such as psychosis or severe depression. * is suffering from substance abuse * is undergoing a psychological treatment * has a high risk of suicide

Keywords: cognitive behavioral therapy psychological well-being resilience refugee migrant youth mental problems
efficacy and safety of asenapine compared with olanzapine in patients with persistent negative symptoms of schizophrenia (a7501013)(completed)(p05771)

Conditions: Schizophrenia

Summary: treatment with conventional antipsychotics such as haloperidol has little effect or may sometimes even worsen negative symptoms (such as blunted affect, emotional withdrawal, and poor rapport) of schizophrenia. the newer "atypical" antipsychotics agents, such as olanzapine, has shown improvement in the treatment of negative symptoms in acute trials. the purpose of this study is to compare an investigational compound (asenapine) with a marketed agent (olanzapine) in the treatment of stable subjects with persistent negative symptoms of schizophrenia for 6 months. patients completing this study may be eligible to participate in an extension 6 months of treatment. patients are required to have stable symptoms prior to entry into study.


Eligibility criteria:
inclusion criteria: * have a documented current diagnosis of schizophrenia of paranoid, disorganized, catatonic, residual, or undifferentiated subtype with persistent negative symptoms. * no increase in level of psychiatric care during the past few months due to worsening of symptoms of schizophrenia. * caregiver required. exclusion criteria: * have an uncontrolled, unstable clinically significant medical condition. * have any other psychiatric disorder other than schizophrenia as a primary diagnosis including depression.
vascular endothelial growth factor and endostatin in angiogenesis after acute ischemic stroke

Conditions: Acute Ischemic Stroke

Summary: vascular endothelial growth factor (vegf) and endostatin (es) participate angiogenesis after cerebral ischemia. circulating endothelial progenitor cells (epcs) also play a crucial role in neovascularization and tissue repair after acute ischemic stroke (ais). the investigators sought to compare the expression of vegf and es in serum and the circulating epcs in patients after ais with that of healthy control subjects. the investigators obtained peripheral blood and serum samples from study subjects. epcs in blood samples from ais patients and healthy controls were quantified by flow cytometry 1 day, 3 days, 5 days and 7 days after ais. vegf and es were measured by enzyme linked immunosorbent assay at the same time points. the relation between them and the relation of them to prognosis of such patients with acute ischemic stroke were assessed.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute ischemic stroke * admission within 12 hours * national institutes of health stroke scale score 6-25 exclusion criteria: * lacunar infarction * cerebral hemorrhagic infarction * epilepsy or epileptic persons * history of neurological diseases, myocardial infarction, renal and hepatic abnormalities and metabolic diseases * contraindications to antiplatelet treatments * died within the first week of hospitalization * serial blood samples could not be obtained

Keywords: acute ischemic stroke vascular endothelial growth factor endostatin
research investigating drug effects-2 (ride-2)

Conditions: Cannabis Use; Substance Use Disorder (SUD); Healthy

Summary: the purpose of this study is to better understand how people's mood, behavior, and brains respond to different recreational drugs. we are also trying to understand why some people may feel differently or their brain may respond differently than other people after taking the same recreational drug.


Eligibility criteria:
inclusion criteria: * age 18-21 at eligibility visit * body mass index of 18.5-30 * report using cannabis ≥10 times in their life and ≥1 time in the past 3 months, but \<7 days a week (daily) * medically and neurologically healthy * score of ≥0.25 on the personality inventory for dsm-5 (pid-5) anhedonia subscale exclusion criteria: * positive urine drug screen (uds; except for thc) and/or positive saliva thc test * contraindication for fmri bold study (e.g., metal implants) * severe mental illness (e.g., psychosis, mania, lifetime moderate-to-severe sud (including moderate-to-severe cud)) * heavy nicotine use in the past month (\>20 cigarettes per week or electronic nicotine delivery system (ends) use equivalent * night shift work * females who are currently pregnant confirmed by urine pregnancy test, are planning pregnancy, or are lactating * unwilling/unable to sign informed consent document * current or past allergic or adverse reaction or known sensitivity to cannabinoid-like substances (dronabinol/marijuana/cannabis/thc, cannabinoid oil, sesame oil, gelatin, glycerin, and titanium dioxide) * physical or neurological diagnoses (e.g., cancer, diabetes, seizure disorder, parkinson's, multiple sclerosis, loss of consciousness \>10 min., etc.) that in the opinion of the study physician and investigators could increase safety risks or influence the findings * currently taking any medication that could interact with a single dose of δ9-thc
intensive versus standard treatment for spinal anesthesia-induced hypotension on maternal hemodynamics

Conditions: Outcome

Summary: the objective of this study is to investigate the impact of varying maternal blood pressure maintenance targets on maternal hemodynamics following cesarean section.

post-spinal anesthesia hypotension is a frequent complication during spinal anesthesia for cesarean section. the incidence of post-spinal anesthesia hypotension is as high as 62.1-89.7% if prophylactic measures are not taken. the 2016 asa guidelines for obstetric anesthesia suggest avoiding hypotension following spinal anesthesia in women and emphasize the use of vasopressors, specifically alpha-receptor agonists, as the preferred strategy to prevent and manage post-spinal anesthesia hypotension. the 2018 international consensus in the united kingdom and northern ireland recommends maintaining maternal systolic blood pressure above 90% of the baseline value following lumbar anesthesia, while avoiding dropping below 80% of the baseline value. currently, the threshold for maintaining blood pressure above 80% of the baseline value is widely adopted as a standard; however, limited evidence supports the advantage of sustaining maternal blood pressure above 90% of the baseline value. the objective of this study is to investigate the impact of varying maternal blood pressure maintenance targets on maternal hemodynamics following cesarean section.

Eligibility criteria:
inclusion criteria: * 18-45 years * primipara or multipara * singleton pregnancy ≥37 weeks * american society of anesthesiologists physical status classification i to ii * scheduled for cesarean section under spinal anesthesia exclusion criteria: * body height \< 150 cm * body weight \> 100 kg or body mass index (bmi) ≥ 40 kg/m2 * eclampsia or chronic hypertension or baseline blood pressure ≥180 mmhg * hemoglobin \< 7g/dl * fetal distress, or known fetal developmental anomaly
genetic abnormalities and biological changes of panic disorder patients after pharmacotherapy

Conditions: Panic Disorder

Summary: we plan to examine genetic polymorphism of catechol-o-methyltransferase in panic disorder and neurobiological changes of panic disorder patients after 12 weeks of pharmacotherapy with paroxetine. we plan to include 40 panic disorder patients and 40 normal control subjects in this study for 3 years.


Eligibility criteria:
inclusion criteria: * panic disorder exclusion criteria: * other major medical or psychiatric illnesses

Keywords: panic disorder paroxetine genetic polymorphism serotonin
core strengthening for dra in postpartum women

Conditions: Diastasis Recti; Postpartum; Low Back Pain

Summary: this study will prospectively measure the effectiveness of a core strengthening program on reducing the inter-rectus distance (ird) and abdominal wall muscle contraction in postpartum women with diastasis rectus abdominus (dra). additionally, this study will aim to investigate and clarify the association between ird and low back pain.

dra is a separation of the abdominal wall muscles that commonly occurs during pregnancy and is caused by the stretching of the linea alba to accommodate a growing fetus. separation of core muscles is thought to be factor in postpartum low back pain, stress urinary incontinence, and core strength, as well as being cosmetically undesirable. this study will evaluate the effect of a core strengthening program on shortening the ird and improving the connectivity and strength of abdominal wall muscles in postpartum women with a dra. it will also investigate the relationship between ird and low back pain.

Eligibility criteria:
inclusion criteria: * healthy women who have given birth within the last 36 months but are at least 12 weeks postpartum * not currently pregnant * current dra diagnosed using ultrasound with an ird of at least 2.0 cm exclusion criteria: * history of ventral/umbilical hernia prior to pregnancy * \>36 months postpartum * currently pregnant * beighton's score \>5/9 * unable to participate in a regular core strengthening program * unable to attend the three data collection sessions
the influence of therapeutic tactics of analgesia on the long-term results of pain treatment in patients with gunshot and mine-explosive wounds

Conditions: Chronic Pain

Summary: considering that in 82.1% of cases it is not possible to achieve a positive result of treatment, the data of our study will play an important role in the treatment of such patients.

the influence of pain management tactics on the long-term results of pain treatment in patients with gunshot and mine-explosive wounds needs to be studied, because the subjective feelings and emotional experiences experienced by patients during the wounding in combat conditions through the prism of psychological disorders have their own characteristics. considering that in 82.1% of cases it is not possible to achieve a positive result of treatment, the data of our study will play an important role in the treatment of such patients.

Eligibility criteria:
inclusion criteria: * the presence of gunshot and mine-explosive injuries exclusion criteria: * absence of gunshot and mine-explosive injuries

Keywords: pain treatment, therapeutic tactics of analgesia, gunshot wounds, mine-explosive wounds, stages of treatment