Kornimate/medical-research-clean huggingface dataset:
metabolic features effects on fast score in masld patients

Conditions: Metabolic Dysfunction-Associated Steatotic Liver Disease

Summary: the goal of this observational cross-sectional study is to evaluate the effect of metabolic features on fibroscan-ast (fast) score stratification in metabolic dysfunction-associated steatotic liver disease (masld) patients in egypt. researchers will identify the metabolic risk factors in patients with masld. evaluate the effect of metabolic features on stratifying masld patients by predicting higher fast score. participants will be subjected to history taking, clinical examination, laboratory investigations, abdominal ultrasonography, and transient elastography (fibroscan) to measure liver stiffness (lsm) and controlled attenuation parameter (cap). the non-alcoholic fatty liver disease (nafld) fibrosis score and fast score will be calculated.


Eligibility criteria:
inclusion criteria: * all patients with masld who had steatosis detected by (vcte-cap) elastography exclusion criteria: * patients with a history of significant alcohol consumption more than 30 g/day in men and \> 20 g/day in women. * patients with positive hepatitis b or c virus markers. * patients with autoimmune hepatitis. * patients with any other metabolic liver disease. * patients with hepatic focal lesions.

Keywords: metabolic dysfunction-associated steatotic liver disease (masld) fast score metabolic features
radiation therapy or chemoradiation, interstitial brachytherapy in combination with hyperthermia in advanced cervical cancer

Conditions: Cervical Cancer

Summary: the combination of radiation therapy or chemoradiation with interstitial brachytherapy for advanced cervical cancer (pn+, figo-stage ii b - iv a is standard of therapy. the radio- and chemosensitive effect of an additional hyperthermia might improve the clinical outcome.


Eligibility criteria:
inclusion criteria: * histological confirmed carcinoma of the cervix * figo-stage iib-iva; earlier stages when inoperable or according to patient's wish * clinical m0; except: involvement of para-aortic lymph nodes * age ≥ 18 years * ecog ≤ 2 * informed consent of the patient exclusion criteria: * pre-existing uncontrolled cardiac disease, signs of cardiac failure, or rhythm disturbances requiring therapy * cardiac pacemaker * myocardial infarction within the past 12 months * congestive heart failure * complete bundle branch block * new york heart association (nyha) class iii or iv heart disease * disease that would preclude chemoradiation or deep regional hyperthermia * metal implants (length \> 2cm or dense clusters of marker clips in the pelvis) * active or therapy-resistent bladder infections * pre-existing or concommitant immunodeficiency syndrome * pregnant or lactating women * patients not willing to use effective contraception during and up to 6 months after therapy

Keywords: radiation therapy chemoradiation brachytherapy hyperthermia cervical cancer multimodality treatment of advanced cervical cancer
long-term follow up of patient with anti-gababr antibodies associated-encephalitis.

Conditions: Autoimmune Encephalitis

Summary: first described in 2010, gaba-b-receptor antibodies-associated encephalitis is a disease with a severe vital and functional prognosis. indeed, functional status is mostly altered by encephalitis and it induced consequences while vital status is mostly engaged by cancer very often associated in the course of the disease, mostly small-cell lung cancer (sclc). while knowledge is growing on clinical features at each stage of the disease, long-term outcome data is still lacking even if known to be pejorative. in this study, we aimed to describe long-term follow up of all patients who were diagnosed a gabab-receptor antibodies-associated encephalitis in the french paraneoplastic neurological syndrome reference center until now.


Eligibility criteria:
inclusion criteria: * encephalitis tested positive to gababr-antibodies after the examination of csf samples tested for autoimmune encephalitis at the french paraneoplastic neurological syndrome reference center from january 2011 to january 2022. exclusion criteria: * tested positive to another onconeural antibody.

Keywords: anti-gababr autoimmune encephalitis outcome
neuroskin forte for dry skin relief in eczema and psoriasis

Conditions: Psoriasis; Eczema

Summary: the purpose of this study is to assess the efficacy of neuroskin forte in relieving the symptoms of dry skin in adults with psoriasis or eczema.

subjects will apply study drug and placebo sprays 3 times a day to the assigned, randomized sides of the body. they are allowed to continue using prescription medications, but not moisturizers. assessments will be performed every other week. total duration of the study is 10 weeks (8 weeks of treatment and a follow-up visit 2 weeks later).

Eligibility criteria:
inclusion criteria * must be at least 18 years of age * have psoriasis or eczema on both sides of the body, with a pair of roughly symmetrical bilateral "target" lesions at least 1.5 cm in diameter exclusion criteria * inability to understand the consent form and/or comply with the requirements of this study * use of moisturizers/emollients within 2 days of beginning study

Keywords: psoriasis dry skin eczema atopic dermatitis
the facing pain study

Conditions: Chronic Pain

Summary: this randomized trial will create and compare two private facebook conditions for patients with chronic pain. the control condition will be comprised of groups of patients who communicate without much clinician / moderator input, and the experimental condition will have a clinician moderating and teaching patients several techniques designed to facilitate social disclosure, validation, and emotional engagement with avoided activities.

this study will investigate the effectiveness of a private facebook group for individuals in chronic pain. currently, more than 100,000 individuals with chronic pain (icps) participate in facebook groups, seeking support from others in similar situations. there are currently some online self-management programs for icps; however, most lack a peer support aspect, as they are individualized, self-directed, and focus on instructing patients in how to manage their pain. the goals of the proposed online pain support group are: 1) to provide peer-to-peer social support for individuals with chronic pain; and 2) to disseminate psychosocial pain management techniques using a social media platform. screened participants will be assigned to one of two conditions: a facebook group similar to the groups that are occurring naturally (control condition) or an enhanced facebook group that is moderated by clinicians and offers psychosocial pain management techniques (experimental condition). both conditions involve peer-to-peer healthcare and support, but the experimental group additionally includes components such as psychoeducation about pain neuroscience, emotional validation training, guided emotional disclosure, and activities to overcome emotional and behavioral avoidance. findings from this study will offer important information about the impact of facebook support groups on pain outcomes, and test whether psychosocial pain interventions can be disseminated using a social media platform.

Eligibility criteria:
inclusion criteria: * must have chronic pain (i.e., pain that persists for greater than 3 months) * must be fluent at reading and writing in english * must have an active facebook account and check facebook at least 3 times a week exclusion criteria: * terminal illness such as cancer * active psychosis (e.g., hallucinations, delusions)
application of high-dose insulin therapy to improve liver function and regeneration

Conditions: Liver Dysfunction; Liver Metastasis Colon Cancer; Liver Regeneration

Summary: the primary objective of this interventional study is determine if the future liver remnant can be optimized by improving liver function pre-operatively in patients who are scheduled for major hepatectomy. the main questions it aims to answer are: 1. does high-dose insulin therapy improve liver function in the pre-operative setting? 2. what is the effect of high-dose insulin therapy on liver function and liver regeneration after a liver venous deprivation (lvd) procedure? 3. what is the relationship between volume hypertrophy and function in the regenerating liver? participants will receive a 6-hour infusion of insulin and dextrose to maintain a hyperinsulinemic-normoglycemic state in the weeks prior to planned liver surgery to assess its effect on liver function measured by 99m-tc-mebrofenin hepatobiliary scintigraphy.


Eligibility criteria:
inclusion criteria: * age \> 18 years old * candidate for major liver resection * resectable colorectal liver metastasis exclusion criteria: * inability to give consent * type 1 diabetes mellitus * uncontrolled blood glucose levels (fasting level \> 10 mmol/l) * unresectable colorectal liver metastasis * extrahepatic metastatic disease that is unresectable

Keywords: hyperinsulinemic-normoglycemic clamp high dose insulin therapy 99mtc-mebrofenin hepatobiliary scintigraphy colorectal cancer liver metastasis liver resection
immunopathology of loeys-dietz syndrome

Conditions: Loeys-Dietz Syndrome

Summary: loeys-dietz syndrome (lds) is a rare vascular genetic disorder (estimated prevalence 1/25,000-1/100,000) due primarily to mutations in the transforming growth factor beta (tgf-β) cytokine receptor 1 and 2 genes. in addition to a common vascular phenotype with marfan syndrome (dilatation of the ascending aorta, arachnodactyly, lens dislocation), patients present specific malformations (bifid uvula, hypertelorism, tortuous arteries) and immuno-allergic manifestations (asthma, eczema, food allergy, eosinophilic esophagitis, chronic inflammatory bowel disease). pathophysiologically, lds appears to be associated with hyperactivation of the intracellular tgf-β signaling pathway in a manner similar to marfan syndrome, as evidenced by increased intracellular phosphorylated smad2/3 (psmad2/3) in lymphocytes. the immuno-allergic complications appear paradoxical because of the major immunosuppressive role of this cytokine on lymphoid and myeloid immune lineages. the biological description of immunological abnormalities associated with lds is based on a single 2013 study that found increased regulatory t (treg) and th2 lymphocyte polarizations, as well as increased circulating eosinophil and total ige levels. in order to better understand the underlying mechanisms, the investigators propose to perform a descriptive clinical-biological study to identify and study the immune subpopulations most impacted by the causative mutations of lds.


Eligibility criteria:
inclusion criteria: for patients with loeys-dietz syndrome: * patients aged ≥ 5 years with loeys-dietz syndrome with a diagnosis confirmed by the presence of a tgf-βr 1 or r2 mutation known to be pathogenic to patients. * free, informed and signed consent from the patient or both parents or legal guardians for minor patients. * patient affiliated to a social security system or similar. for healthy volunteers: * subjects aged ≥ 5 years. * free, informed and signed consent of the witness, or if applicable of both parents or legal representatives for minors. * patient affiliated to a social security system or similar. exclusion criteria: for patients with loeys-dietz syndrome: * patient with an evolving or recently healed (\< 3 months) cancer that could alter the immunologic profile. * patient with an evolving or recently healed (\< 3 months) infection that could alter the immunologic profile. * patient with a weight of less than 20 kg. * pregnant woman. * patient participating in another research study with an exclusion period exclusion period still in progress. for healthy volunteers: * subject with an active or recently cured (\< 3 months) cancer that could alter the immunologic profile. * subject with an active or recently healed (\< 3 months) infection that could alter the immunological profile. * patient with a weight of less than 20 kg. * pregnant woman. * subject participating in another research study with an exclusion period exclusion period still in progress. * persons under court protection.

Keywords: loeys-dietz syndrome immunology t-lymphocytes
impedance threshold device tilt study

Conditions: Orthostatic Hypotension

Summary: this study will see if a special piece of equipment can help burn patients who have been in bed for a long time to get out of bed without feeling dizzy or faint.

to measure stroke volume, cardiac output, arterial blood pressure and cerebral blood flow velocity in human patients while they undergo exposure to head-up tilt that is designed to test their tolerance to an orthostatic challenge.

Eligibility criteria:
inclusion criteria: * military or civilian males or females between the ages of 18-65 years * burn injury with at least one unburned finger for portapres measurement * minimum of 96 hours bedrest or physician directive to tilt exclusion criteria: * age \ 65 years * facial burns when application of itd device would cause further trauma * medical monitoring devices that preclude the use of the itd * signs of cardiac abnormalities, autonomic dysfunction * chronic obstructive pulmonary disease (copd), or any other respiratory limitations (ventilator dependent, intubated, tracheostomy) limiting use of itd * history of pre-syncopal/syncopal episodes or orthostatic hypotension * history of atherosclerotic coronary heart disease * patients taking any kind of cardiovascular pressor medications * inability to obtain a portapres pulse wave validated by blood pressure cuff with +/- 5mmhg diastolic blood pressure * unable to provide informed consent for self

Keywords: inspiratory impedance threshold device blood pressure regulation head-up tilt test tilt table testing burn injury burns
effects of physical exercise on sarcopenia after bariatric surgery

Conditions: Sarcopenic Obesity; Bariatric Surgery Candidate

Summary: the study will include 60 patients awaiting bariatric surgery. they will be randomized into 2 groups, experimental and control. the intervention will take place 1 month after surgery, for a total of 16 weeks. parameters of body composition, metabolic risk, quality of life, physical activity and sedentary behavior will be determined

bariatric surgery is the treatment of severe obesity with associated pathologies, with proven evidence in its benefits. treating overweight allows a better and even reversal of pathologies associated with obesity. in this context, we know that physical exercise is important in the process of weight loss, however, and especially in bariatric surgery, the characteristics of physical activity are not consensual, as well as the effect of programs and physical exercise in this population. weight loss associated with bariatric surgery is greatly associated with a significant reduction of skeletal muscle and bone mineral mass, which leads us to induce that after bariatric surgery, patients incur an increased risk of sarcopenia. the need for prophylactic programs that prevent sarcopenia in bariatric surgery patients seems to be one of the crucial points for the framing of long-term surgical success of bariatric and metabolic surgery. this randomized clinical trial will aim to study the effects of a 16-week supervised exercise intervention program on the prevention of sarcopenia after bariatric surgery this randomized controlled trial study will include 60 patients of both sexes on the waiting list for bariatric surgery and who have subsequently performed the surgery. they will be randomized into 2 groups, experimental and control. the intervention will take place 1 month after surgery, for a total of 16 weeks. parameters of body composition, metabolic risk, quality of life, physical activity, and sedentary behavior will be determined. assessments will take place in five moments, the surgery, the intervention, the post-intervention, six months after the intervention, twelve months after the intervention.

Eligibility criteria:
inclusion criteria: * as inclusion criteria, patients should be enrolled for bariatric surgery at the hospital * aged between 18 years and 60 years * contraindication to the practice of exercise * agree to participate in the study exclusion criteria: * patients with problems in locomotion * surgical complications * psychiatric diseases and neurological disorders

Keywords: bariatric surgery quality of life metabolic risk factors, fat-free mass sarcopenia exercise
effects of flapless laser corticotomy in canine retraction

Conditions: Dental Malocclusion; Bimaxillary Protrusion

Summary: this study is conducted to evaluate the effects of flapless laser corticotomy on the rate of canine retraction.


Eligibility criteria:
inclusion criteria: * full complement of teeth with no congenitally missing teeth except 3rd molars. * minor or no crowding cases requires four premolars extraction, canine retraction \& maximum anchorage with bimaxillary dentoalveolar protrusion. * no history of previous orthodontic treatment * clinically healthy patients with no history of drug intake and\\or no history for any systemic illness, syndromes, craniofacial deformities. * vital teeth with normal periodontium and no root resorption. * adequate oral hygiene; probing depth values not exceeding 3 mm across the entire dentition; adequate thickness of the attached gingiva (1-2 mm). * no radiographic evidence of bone loss. exclusion criteria: * systemic disease that might have affected bone formation or density, such as osteoporosis, hyperparathyroidism, or vitamin d deficiency. * presence of any local or systemic surgical contraindication. * extracted or missing permanent tooth/teeth except for 3rd molars. * facial asymmetry

Keywords: flapless laser corticotomy canine retraction
a feasibility study investigating chemotherapy-induced neuropathy using multi-frequency tactilometry and patient-reported outcomes (pro)

Conditions: Chemotherapy-induced Peripheral Neuropathy

Summary: chemotherapy induced peripheral neuropathy (cipn) is among the most feared side effects to cancer treatment. the development of cipn can lead to discontinuation or omission of antineoplastic drugs, possibly affecting efficacy of cancer treatment. there is a lack of knowledge about the natural course of cipn and to this date, there are no available methods for the early detection of cipn. with no effective prevention or treatment options, the condition has severe impact on patient quality of life and healthcare expenditure. this study will investigate the natural course of paclitaxel- and oxaliplatin induced peripheral neuropathy using novel diagnostic techniques. multi-frequency vibrational technology has provided an objective method for the early detection of diabetic neuropathy. our study will test the feasibility of this method within the field of clinical oncology and cipn.


Eligibility criteria:
inclusion criteria: * ≥ 18 years of age * a diagnosis of cancer. * fulfil the criteria for starting chemotherapy. * scheduled to undergo at least 4 courses of paclitaxel- or oxaliplatin-based chemotherapy. * no prior paclitaxel, oxaliplatin or other neurotoxic chemotherapy. exclusion criteria: * unable to complete pro measures. * previous neurotoxic chemotherapy.

Keywords: cipn qst chemotherapy-induced peripheral neuropathy neurotoxic chemotherapy oxaliplatin paclitaxel tactilometry
transcutaneous auricular vagus nerve stimulation to enhance motor learning

Conditions: Neurological Injury; Motor Disorders; Paresis

Summary: vagus nerve stimulation (vns) activates neural pathways leading to the release of chemicals that promote plasticity and learning. previous work has shown that the auricular branch of the vagus nerve innervates landmarks on the external ear. work from the pi's laboratory has shown that electrical current applied to the external ear activates neural pathways implicated in the therapeutic effects of vns. the broad objective of this project is to better understand physiological mechanisms that are modulated by auricular stimulation and its potential to enhance motor learning.


Eligibility criteria:
inclusion criteria: (for prospective subjects diagnosed with stroke) * confirmed diagnosis of a single stroke at least six months prior to participation exclusion criteria: * history of vestibular disorders or dizziness * diagnosis of neurological disorders affecting movement * ocular disease and/or impairment in more than one eye * pregnant or expecting to become pregnant * difficulty maintaining alertness and/or remaining still
intrauterine human chorionic gonadotrophins (hcg) and endometrial treg cells

Conditions: Infertility

Summary: intrauterine injection of hcg around the time of implantation may increase endometrial treg cells and improve implantation. it has been demonstrated that regulatory t cells expand during pregnancy. hcg was found to be secreted by the embryo immediately after fertilization and has chemoattractant properties to treg cells.

aim of the work: to study the effect of intrauterine injection of human chorionic gonadotrophin on the endometrial t regulatory cells (treg cells)and the electromicroscopic endometrial characteristics. background: it has been demonstrated that regulatory t cells expand during pregnancy and are present at the feto-maternal interface at very early stages in pregnancy. rational: intrauterine injection of hcg around the time of implantation may increase endometrial treg cells and improve implantation. methods: intrauterine injection of 100 iu hcg will be done followed by endometrial biopsy to check for treg cells and pinopodes.

Eligibility criteria:
inclusion criteria: * male factor infertility * ovulatory factor infertility * unexplained infertility * female age less than 39 exclusion criteria: * azoospermia * tubal factor infertility * pelvic endometriosis

Keywords: hcg treg cells implantation pinopodes endometrium
vitamin d administration in the nursing home

Conditions: Vitamin D Deficiency; Osteoporosis

Summary: administration of vitamin d 50,000 units once monthly will: * maintain serum 25-oh vitamin d above 20 ng/ml * reduce falls * increase calcaneal bmd * reduce bone turnover * be well tolerated: volunteers will not develop hypercalcemia * improve performance on a swallowing quality of life questionnaire

1. research questions: we propose a prospective double-blind, randomized, placebo-controlled trial of once-monthly vitamin d oral capsules (50,000 units) in nursing-home residents. subjects from several wisconsin nursing homes were randomized to receive once-monthly vitamin d oral capsules (50,000 units) or placebo. blood levels of 25-oh d, parathyroid hormone, serum calcium, and a marker of bone turnover will be measured periodically by standard lab assays. swallowing quality of life was measured by questionnaire. appropriate statistical tests (paired t tests, 95% confidence intervals will be calculated with the large sample approximation for binomial variables, other).

Eligibility criteria:
inclusion criteria: * male or female * nursing home resident in wisconsin exclusion criteria: * renal failure * hypercalcemia * metastatic cancer

Keywords: osteoporosis vitamin d deficiency