Kornimate/medical-research-clean huggingface dataset:
weight gain during pregnancy - a randomized controlled trial of intervention to prevent excessive gestational weight gain

Conditions: Weight Gain

Summary: excessive weight gain during pregnancy is associated with complications during delivery primarily due to macrosomia (large babies) but also with high levels of weight retention post pregnancy and thereby increased risk of future weight related health problems. the primary aim of this study is to evaluate the efficacy of an intervention consisting of; recurrent motivational interviewing (mi), prescription of physical activity and extended information on recommended weight gain during pregnancy in regards to preventing excessive gestational weight gain.


Eligibility criteria:
inclusion criteria: * \>18 years, * adequate language skills (swedish), * bmi\>19.9, * pregnancy estimated \<16 weeks (lmp), * planned for basic pregnancy surveillance (healthy mother). exclusion criteria: * history of eating disorder, * history of having a growth restricted child.

Keywords: pregnancy weight gain obesity macrosomia
college student daily life and alcohol use study

Conditions: Drinking, College; Drinking Heavy

Summary: heavy alcohol use among college students is associated with a range of negative consequences. however, college students rarely seek resources or treatment to change their alcohol use. brief alcohol interventions (bais) have been developed as an alternative method to address heavy alcohol use among college students and show promise in reducing hazardous alcohol use in college students. despite the established efficacy of bais, effects are often small and short-lived, and additional research is needed to investigate how bais can become more efficacious and endure for longer periods of time, particularly for computer-delivered interventions to improve accessibility and scalability of these interventions to a wider range of college students. boosters or adjunctive components to bais have been suggested as a method to enhance the magnitude and duration of intervention effects. however, there remains a need to identify and test booster approaches that are both appealing and engaging to college students and effective in reducing heavy/hazardous alcohol use above and beyond the magnitude and duration seen by bais alone. the purpose of the study is to develop and test a novel, text-messaging booster as an adjunct to a current, evidence-based brief intervention, echeckup to go, aimed at reducing college student heavy/hazardous alcohol use. participants will complete baseline measures and will then be randomized to 1 of 3 conditions, stratified by sex at birth: 1) assessment only, 2) bai only, and 3) enhanced intervention (bai + four weeks of text messaging boosters). it is hypothesized that those randomized to the enhanced intervention condition will show a greater reduction in heavy/hazardous alcohol use at 3-month follow-up compared to the bai and assessment only groups.


Eligibility criteria:
inclusion criteria: * 1) ages 18-30; 2) report at least 2 heavy drinking episodes in the past month; 3) be enrolled in an undergraduate degree program; 4) own a smartphone with capability to run smartphone application exclusion criteria: * 1) current or past-year treatment (counseling or medication) for alcohol or drug use, 2) history of delirium tremens and/or seizures as a result of alcohol withdrawal, and 3) a lifetime diagnosis of either bipolar disorder or schizophrenia

Keywords: heavy alcohol use college student brief alcohol intervention
postoperative stress response in patients following fast track vs conventional protocol after hepatectomy or pancreatectomy

Conditions: Hepatic Cancer; Cancer of Pancreas

Summary: a prospective randomized clinical study, with cross-sectional comparisons and correlations was conducted from may 2012 to july 2015 with a sample of 231 patients who have undergone hepatectomy or pancreatectomy, randomized into 2 groups. in group a was applied postoperatively the protocol fast-track, while in group b the conventional postoperative care. demographic and clinical data were collected. in 170 patients, neuropeptide y (npy), adrenocorticotropic hormone (acth)/cortisol plasma levels were measured by elisa method: a) at the day of patient's admission, b) the operation day, c) the 3rd postoperative day or prior to discharge.

pain levels were assessed by puntillo scale (behavioral observation scale) which has ranges; 0-1 "no pain", 2-4 "aching" 5-7 "moderate pain" 8-10 and "severe pain". patient stress levels were evaluated by: a) scale i.c.u.e.s.s. which evaluated environmental stress during their stay in hospital and takes values; 40-80 "no environmental stress" 81-120 "mild to moderate environmental stress," 121-160 " moderate to severe environmental stress ", b) three questions of self- experienced feelings (with a score of 0 = none and 10 = completely) like "how sad you feel right now?" "how stress do you feel right now?" "how optimist do you feel right now about the future?" the data collected in three phases: a) the day of hospitalization, b) the day of surgery, and c) the third postoperative day or before discharge. depression levels were evaluated with zung scale (zung self-rating depression scale), which assesses depression levels with a score 25-49 for "normal level mood," 50-59 for "mild depression", 60-69 for "moderate depression" and 70 + for "severe depression".

Eligibility criteria:
inclusion criteria: * patients with american society of anesthesiologists (asa) physical status classification system i-iii * age 30-82 years, * with normal level of consciousness and communication exclusion criteria: * the presence of chronic pain, * kidney disease, neuropathy, * systemic as well as chronic treatment with analgesics

Keywords: fast track surgery eras program hepatectomy pancreatectomy npy acth/cortsiosol postoperative stress
yoga breath program and client-centered exposure for relief of ptsd in tsunami victims

Conditions: Posttraumatic Stress Disorder; Depression

Summary: study hypothesis: that a standardized course of eastern practices (breath water sound course -bws) will significantly relieve ptsd and depression in tsunami victims. further, that a client-centered exposure treatment (traumatic incident reduction- tir) would provide additional, significant relief of ptsd and depression in tsunami victims. 180 tsunami victims in southern india will be divided into three groups: those that only receive bws course, those that receive the bws course and tir and a wait-list control. they will be pretested with the pcl-17 (ptsd scale), the beck depression inventory and the general health questionaire. these scales will also be administered post-service as well as five weeks post pre-testing and at three and six month intervals.


Eligibility criteria:
inclusion criteria: 1. tsunami witness, tsunami victim, and/or lost loved one or property. 2. ages 18-70 3. willing to participate for the entire length of this research study. exclusion criteria: 1. drug addiction, notwithstanding alcohol or tobacco. 2. schizophrenia or other severe pre-existing mental illness 3. severe physical disability or illness that would prevent study completion.

Keywords: posttraumatic stress disorder depression disaster mental health yoga breathwork exposure treatments
postprandial nutrient homeostasis before and after weight loss induced by low-calorie diet or rygb

Conditions: Obesity

Summary: the purpose of this study is to compare the metabolic responses to low-carbohydrate and standard-carbohydrate meals in african americans and non-hispanic white adults with obesity and the effect of weight loss induced by low-calorie diet (lcd) or roux-en-y gastric bypass (rygb) on the metabolic responses to low-carbohydrate and standard meals. participants will consume: 1) a standard-carbohydrate meal (\~49 g glucose) and 2) a low-carbohydrate (\~3.4 g glucose) meal on separate study visits performed in a randomized order. we will evaluate the meals' effect before and after \~16-18% weight loss on postprandial i) insulin kinetics, ii) glucose kinetics iii) β-cell function; iv) plasma triglyceride and non-esterified fatty acid concentrations; v) plasma hormone concentrations; vi) plasma cytokine concentrations; vi) plasma metabolomics; and vii) adipose tissue transcriptomics.


Eligibility criteria:
inclusion criteria: surgery group (rygb): * males and females * scheduled for rygb surgery * body mass index 35-60 kg/m² * without type 2 diabetes (t2d) lcd group: * males and females * body mass index 35-60 kg/m² * without type 2 diabetes (t2d) exclusion criteria: * regular use of tobacco products * previous intestinal resection * pregnant or breastfeeding * evidence of significant organ system dysfunction or disease other than obesity and t2d * use of any medication that might, in the opinion of the investigator, affect metabolic function * exercise ≥90 minutes per week * use or past use of hormone replacement therapy within the past 6 months

Keywords: obesity roux-en-y gastric bypass (rygb) low calorie diet
ficus septica leaves fraction as a complementary therapy for stadium iv breast cancer patients

Conditions: Breast Cancer Stage IV

Summary: the purpose of this research is to assess the safety profile and clinical benefit of awar-awar leaf active fraction as a complementary therapy in chemotherapy of stage iv breast cancer

the study uses a double blind design and randomized controlled trial that compares the safety and clinical efficacy profiles of 3 treatment groups (each consists of 97 subjects who received chemotherapy for 6 cycles). the treatment group was given fada at a dose of 800 mg/day and 2000 mg/day compared to the placebo group. interim analysis is carried out after 25% of the subjects completed 3 cycles of chemotherapy; whereas interim analysis ii is carried out after 50% of the subjects completed 3 cycles of chemotherapy.

Eligibility criteria:
inclusion criteria: * female, at least 18 years old * welfare scale 0, 1, and 2 (ecog - who) * patients with stage iv breast cancer who have histopathological data according to the tnm classification of malignant tumors (tnm) from american joint committee on cancer (ajcc) 8th edition 2017 * patients who are willing to participate in the test and sign an informed consent * patients who undergo breast cancer chemotherapy with luminal b sub-type or triple negative with anthracycline base * patients who are willing and able to fill out a questionnaire * the patients who are willing and able to comply with the test protocols during the test exclusion criteria: * unable to meet the test protocol * patients with liver and kidney disorders * patients with other diseases/disorders that are meaningful according to the investigators will be excluded from the test * patients with cancer that has metastasized to the brain * pregnant women and breastfeeding mothers * patients with the ejection fraction smaller-than or equal to 55%

Keywords: ficus septica cancer doxorubicin adjuvant
lower third molar removal with 2% and 4% articaine

Conditions: Impacted Third Molar Tooth; Adverse Reaction to Other Local Anesthetics

Summary: the present clinical trial randomized compared the clinical efficacy of the local anesthetics articaine in two concentrations, 2% and 4%, in association with 1:200,000 adrenaline, for the removal of lower third molars. onset, duration of postoperative analgesia, duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative mouth opening and wound healing at the 7th postoperative day were evaluated. for this purpose, 50 healthy volunteers underwent removal of symmetrically positioned lower third molars, in two separate appointments (one to two months apart), under local anesthesia with either articaine 2% or 4% (both with 1:200,000 adrenaline) in a double-blind, randomized and crossed manner.

the present clinical trial randomized compared the clinical efficacy of the local anesthetics articaine in two concentrations, 2% and 4%, in association with 1:200,000 adrenaline, for the removal of lower third molars. onset, duration of postoperative analgesia, duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative mouth opening and wound healing at the 7th postoperative day were evaluated. this study evaluated the clinical efficacy of two concentrations (2% and 4%) of the local anesthetic articaine, a local anesthetic of moderate duration, associated with adrenalin at 1: 200,000 in 50 patients aged less than 18 years and in need of extraction of the two third molars with similar positions. evaluated the following parameters: 1) onset of action of the anesthetic agent, 2) the total amount of anesthesia used during surgery, 3) onset and duration of surgery after the administration of the local anesthetic, 4) the incidence, type and severity of adverse reactions, 5) postoperative control of mouth opening, 6) subjective evaluation of postoperative pain, 7) postoperative duration of anesthesia, 8) total amount of relief medication and 9) heart rate and systolic and diastolic blood pressure before during and after surgery. the comparative analysis of the data and the application of proper statistical tests provided the basis for an assessment of the efficiency of both concentrations of the local anesthetic articaine (2% and 4%) with adrenalin at 1: 200,000.

Eligibility criteria:
inclusion criteria: * need of lower third molar surgeries in similar positions exclusion criteria: * presence of systemic diseases; * presence of local inflammation and/or infection; * any history of allergic reaction to local anesthetics, gastrointestinal bleeding or ulceration; * cardiovascular and kidney diseases; * asthma and allergy to aspirin, piroxicam or any other non-steroidal antiinflammatory drug; * regular use of any non-steroidal antiinflammatory drug, pregnancy or breast feeding.

Keywords: articaine lower third molar oral surgery
gastric tube in pyloric stenosis

Conditions: Hypertrophic Pyloric Stenosis; Respiratory Complication

Summary: pyloric stenosis is a current condition in pediatric surgery. the medical management prior to surgery consists of ionic correction. the nasogastric tube is commonly used to prevent gastric fluid inhalation before surgery, but there is no study on it benefits in this specific use. other studies suggest that utilization of a gastric tube in pyloric stenosis may increase the duration of the medical treatment. the aim of the study is to evaluate the benefit of the nasogastric tube to prevent respiratory complications. this retrospective, monocentric and descriptive study include all patients hospitalized for pyloric stenosis in the university hospital in amiens between 2014 and 2021. patients with and without nasogastric tube prior to surgery are compared, regarding respiratory complications define as use of antibiotic, or oxygen therapy or infection in the lungs x-ray before surgery. the investigators analyze pre-operative data: vomiting, dehydration, time to ionic disorders correction and pain, and also notice the length of hospital stay. data during hospitalization are analyzed and will be noticed the last medical contact represent by the post-operative consultation.


Eligibility criteria:
inclusion criteria: * all patients with hypertrophic pyloric stenosis exclusion criteria: * refusal of data collection and use from patient's parent or family

Keywords: hypertrophic pyloric stenosis gastric tube respiratory complication
trigger point injections and pelvic rehabilitation for the treatment of pelvic floor myalgia and sexual pain

Conditions: Dyspareunia

Summary: the purpose of this study is to evaluate which treatment option for pelvic floor pain allows for improved sexual function.

pelvic floor pain may be treated with trigger point injections with medications (steroids and local anesthetics) that are fda approved for injection into muscles. the alternative is a noninvasive treatment option using pelvic rehabilitation which involves vaginal muscle massage. both treatment options have been used and reported; however, rapidity of improvement and return to normal sexual function have not been assessed. this study assigns patients to either treatment option randomly and the sexual function is assessed based on standardized sexual function questionnaires as well as pain ratings.

Eligibility criteria:
inclusion criteria: * pelvic pain * pelvic floor myalgia * dyspareunia * female * age \> 18 years exclusion criteria: * interstitial cystitis * vaginal lesions / ulcerations * prior trigger point injections in the past 6 months * prior pelvic rehabilitation in the past 6 months * laparoscopically documented endometriosis / pelvic adhesions or adhesive disease * documented pelvic inflammatory disease identified within the past 6 months * documented sexually transmitted disease within the past 6 months

Keywords: pelvic floor myalgia trigger point injections pelvic rehabilitation dyspareunia
a study of valganciclovir in the treatment of cytomegalovirus (cmv) retinitis in patients with aids

Conditions: Cytomegalovirus Retinitis; HIV Infections

Summary: the purpose of this study is to see if valganciclovir is a safe treatment for cmv retinitis in patients who have been treated for this condition in the past. this study also examines the effectiveness of valganciclovir in preventing the recurrence of cmv retinitis.

patients receive valganciclovir twice a day for 21 days as induction therapy then daily as maintenance therapy. patients are encouraged to remain on study for at least 3 months and will remain until common study closure.

Eligibility criteria:
inclusion criteria concurrent medication: allowed with caution: * acyclovir. * famciclovir. * valaciclovir. * imipenem-cilastatin. * myelosuppressive agents. patients must have: * hiv infection with cmv retinitis. * minimum of 4 weeks prior treatment with ganciclovir, foscarnet, or cidofovir. * intraocular implant in either or both eyes, as long as cmv retinitis is active in one eye, upon approval by roche. exclusion criteria co-existing condition: patients with any of the following symptoms of conditions are excluded: * active extraocular cmv disease. * severe uncontrolled diarrhea or evidence of malabsorption. concurrent medication: excluded: * foscarnet. * cidofovir. * cmv hyperimmune globulin. * probenecid. patients with the following prior conditions are excluded: * ocular media opacities (corneal, aqueous, lens, or vitreous) preventing ophthalmologic retinal assessment. * simultaneous participation in another study (unless approved by roche). required: * a minimum of 4 weeks treatment with ganciclovir, foscarnet, or cidofovir. * approval required for prior use of investigational anti-cmv agents.

Keywords: aids-related opportunistic infections ganciclovir antiviral agents drug administration schedule cytomegalovirus retinitis prodrugs
satavaptan dose-ranging study in hyponatraemic patients with cirrhotic ascites

Conditions: Ascites; Liver Cirrhosis

Summary: the primary objective is to determine the optimal dose or range of doses of sr121463b for the treatment of ascites and the correction of hyponatraemia when used concomitantly with a standard dose regimen of spironolactone. the secondary objective is to determine the tolerability of different fixed doses of sr121463b over a 14 day treatment period in cirrhotic ascites. this hypo\~cat study is followed by a single-blind, placebo-controlled, one-year long-term safety extension (expo\~cat). the first extension is followed by another long-term study (pasccal-1).


Eligibility criteria:
inclusion criteria: * cirrhosis of the liver confirmed by ultrasound, endoscopic examination, or biochemical evidence * moderate or tense ascites * patients with hyponatremia, defined as a serum sodium concentration of ≤130 mmol/l the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Keywords: cirrhotic ascites hyponatraemia
psychotherapy for ketamine's enhanced durability in chronic neuropathic pain: a randomized controlled pilot trial

Conditions: Neuropathic Pain

Summary: the purpose of the study is to investigate new therapies to alleviate pain on neuropathic chronic pain. at this time, the main purpose is to complete a feasibility or pilot study with 60 participants suffering from neuropathic chronic pain. participants will be randomized to (1) ketamine (hydrochloride) hcl; (2) psychotherapy (using cognitive behavioral therapy); or (3) a combination of ketamine hl and psychotherapy.


Eligibility criteria:
inclusion criteria: 1. ≥18 years of age 2. diagnosis of chronic neuropathic pain as determined by a pain specialist with moderate-to-severe neuropathic pain as per id pain questionnaire, with mean pain scores \> 3 on a numeric rating scale (nrs), in the 7 days preceding inclusion 3. for participants of childbearing potential, use highly effective or double-barrier methods of contraception. abstinence is acceptable if it is the preferred and usual lifestyle of the participant 4. capacity to provide informed consent exclusion criteria: 1. patients less than 18 years of age 2. current or lifetime history of schizophrenia, psychotic disorder, bipolar disorder, or borderline personality disorder 3. known history of hypersensitivity or allergy to ketamine-hcl 4. current history of dissociative disorders 5. current concomitant use of theophylline or aminophylline 6. current elevated intracranial pressure 7. pregnancy or ongoing breastfeeding in female participants 8. concomitant active substance use in the 6 months preceding enrolment (amphetamines, alcohol, and ketamine) 9. contraindication to receiving ketamine-hcl (e.g. current or lifetime history of cerebrovascular accident; current significant hypertension \[systolic blood pressure higher than 160 mmhg and/or diastolic blood pressure higher than 100 mmhg\]; current severe cardiac decompensation \[e.g. presence of dyspnea, peripheral edema, elevated jugular venous pressure, hepatomegaly, pulmonary rales, pleural effusions\])

Keywords: feasibility trial ketamine cognitive behavioural therapy
application of 3d scanner to measure physical size in patients with severe cerebral palsy

Conditions: Cerebral Palsy, Spastic

Summary: the aim of this study is to improve the manufacturing techniques of hip brace in preventing progressive hip displacement in patients with severe cerebral palsy, through the measurement of patient's physical size using a 3d scanner.

1. design : prospective study 2. setting: hospital rehabilitation department and home 3. intervention: before starting the study, radiologic and clinical evaluation were performed. after measuring the patient's exact physical size by applying a 3d scanner, we manufacture hip brace in preventing progressive hip displacement in patients with severe cerebral palsy. after wearing for a week, follow-up radiologic and clinical evaluation were performed. 4. main outcome measure 1) primary outcome: right, left, both hip mi 2) secondary outcomes: the hip and knee joint range of motion (rom), pain intensity, satisfaction and discomfort score for the hip brace, quality of life (qol) of the patients and their caregivers, and the wearability test.

Eligibility criteria:
inclusion criteria: 1. diagnosis of cerebral palsy 2. age 1-15 years 3. gmfcs level iv, v 4. quadriplegia, or diplegia for more than 6 months 5. patients who have written consent with permission from the child and caregiver. exclusion criteria: 1. patients who did not agree to participate in the study 2. patients who refused the examination 3. patients who had hip surgery experience 4. patients who were scheduled to undergo surgery during the clinical study 5. patients who could not be measured with a 3d scanner

Keywords: 3d scanner cerebral palsy hip dislocation orthotic devices protective devices