Kornimate/medical-research-clean huggingface dataset:
efficacy of sequential tace and pve on the resectability of hepatitis b related hcc

Conditions: Hepatocellular Carcinoma

Summary: a primary hepatocellular carcinoma (hcc) is generally regarded as unresectable if the future liver remnant (flr)≤40％ of total liver volume in patient with underlying liver disease, such as hepatitis b. in china, tace is the most common treatment for these unresectable hcc. recently, pve has been employed to enlarge the flr of the patients so as to increase the resectability and surgical safety of major hepatectomies. in order to shut the arterio-portal shunt in the liver and control the tumor progress tace sometimes is performed before pve. in this study we design a randomized control trial to investigate the efficacy of sequential tace and pve on increasing the resectability of hepatitis b related hcc compared with tace alone.

in china, primary hepatocellular carcinoma (hcc) is mostly a hepatitis b related disease. the liver function of these patients has been damaged, which often limit the execution of major hepatectomy. a tumor is generally regarded as unresectable if the future liver remnant (flr)≤40％ of total liver volume in patient with underlying liver disease. in china, tace is the most common treatment for these unresectable hcc. tace can slow down tumor progress but has little effect on enlarging flr. recently, pve has been employed to enlarge the flr of the patients so as to increase the resectability and surgical safety of major hepatectomies. but the intrahepatic arterioportal shunt and the tumor progress has decreased the effect of pve. in order to shut the arterioportal shunt and control the tumor progress tace sometimes is performed before pve. in this study we design a randomized control trial to investigate the efficacy of sequential tace and pve on increasing the resectability of hepatitis b related hcc compared with tace alone.

Eligibility criteria:
inclusion criteria: 1. age:20-65years old; 2. with a clinical diagnosis of primary liver cancer, with hbsag positive,without any therapy for tumor; 3. single lesion with a diameter \>6.5cm,or multiple lesions locating within half liver or adjacent three lobe; 4. estimated liver remnant volume ≤40% 5. with a liver function of child-pugh class a,and alt≤80iu/l. exclusion criteria: 1. reject to attend； 2. portal vein trunk has been compressed by tumor; 3. diffuse type cancer or with extensive cancer thrombus in main branches of pv,hv,ivc or bile duct; 4. with extrahepatic metastasis; 5. with obvious portal hypertension (with moderate to severe varix in esophagus and/or gastric fundus, enlarged spleen,wbc\<4×109／l, plt\<80×109／l) 6. with diabetes 7. allergy to iodine

Keywords: hepatocellular carcinoma hepatitis b transarterial chemoembolization (tace) portal vein embolization (pve) surgical resection disease-free survival overall survival
comparison of breathing event detection by a continuous positive airway pressure device to clinical polysomnography

Conditions: Sleep Apnea

Summary: the study is to compare the performance of a cpap (continuous positive airway pressure) device to a clinical polysomnography (psg) in identifying breathing events in patients with obstructive sleep apnea.

purpose: the purpose of this study was to compare the aed algorithm used in a pap device with manually scored events on psg. the pap device was modified to produce a square wave voltage output identifying when apneas, hypopneas, and snoring events were detected. recording this event signal on the psg performed with the patient using the pap device allowed an event-by-event comparison between manually scored psg events and aed events. in addition, the ahi, ai, and hi derived from the manually scored psg were compared with the respective measures reported by the pap device used during the psg. study objectives: compare automatic event detection (aed) of respiratory events using a positive airway pressure (pap) device with manual scoring of polysomnography (psg) during pap treatment of obstructive sleep apnea (osa). design: prospective psgs of patients using a pap device. setting: six academic and private sleep disorders centers. interventions: a signal generated by the pap device identifying the aed of respiratory events based on airflow was recorded during psg.

Eligibility criteria:
inclusion criteria: 1. age 21-75 2. diagnosis of osahs with a baseline ahi ≥ 15 events/hr of sleep assessed january 01, 2007 or later 3. cpap prescription of 8cm of h20 or higher 4. able and willing to provide written informed consent 5. native english speaker exclusion criteria: 1. participation in another interventional research study within the last 30 days 2. major medical or psychiatric condition that would interfere with the demands of the study and adherence to pap. examples include unstable cardiovascular disease (class iii / iv chf), neuromuscular disease, cancer, and renal failure. 3. chronic respiratory failure or insufficiency with suspected or known neuromuscular disease, moderate or severe continuous positive airway pressure (copd) or other pulmonary disorders, or any condition with an elevation of arterial carbon dioxide levels (\> 45 mmhg) while awake, or subjects requiring continuous oxygen therapy. 4. surgery of the upper airway, nose, sinus, or middle ear within the previous 90 days 5. surgery at any time for the treatment of osahs such as uvulopalatopharyngoplasty (uppp) 6. presence of untreated or poorly managed,non-osahs related sleep disorders: 1. moderate to severe periodic limb movements(≥ 30/hr with symptoms or arousals) 2. arousals associated with periodic limb movements \> 10 per hour or 3. anyone experiencing chronic and severe insomnia. 7. consumption of ethanol immediately prior to the research psg
effect of terlipressin for intraoperative blood pressure management in kidney transplantation

Conditions: Kidney Transplant; Delayed Graft Function; Intraoperative Hypotension

Summary: prospective double blind randomized controlled trial. by randomizing patients undergoing kidney transplantation into a conventional catecholamine drug (dobutamine) blood pressure maintenance group and a terlipressin-complexed dobutamine group, the investigators compared the effect of intraoperative blood pressure maintenance and the dosage of the vasoactive drug, postoperative graft function, delayed graft function, and other related complications between the two groups, in order to demonstrate whether the use of terlipressin for blood pressure regulation during kidney transplantation is superior to the existing treatments.


Eligibility criteria:
inclusion criteria: * patients with end-stage renal disease aged 18 years or above exclusion criteria: * simultaneous multiple organ transplantation * known allergy to study medication * known pregnancy status * cancellation of surgery due to grafts or personal reasons * persistent severe preoperative hypertension that may not require intraoperative supportive therapy with vasoactive medications * any other reason that the supervising physician or the anesthesiologist on duty think the patient is not suitable for the study
spinal cord stimulation for predominant low back pain

Conditions: Failed Back Surgery Syndrome; Back Pain; Pain in Leg, Unspecified

Summary: the purpose of this study is to compare the effectiveness of spinal cord stimulation (scs) using the medtronic specify® 5-6-5 multicolumn surgical lead plus optimal medical management (omm) versus omm alone in patients suffering from predominant low back pain due to failed back surgery syndrome (fbss).

the study has a multi-center, prospective, randomized (1:1), open-label, parallel-group design of two alternative treatments: * scs group (scs+omm) * omm group

Eligibility criteria:
inclusion criteria: * scs candidate with the specify 5-6-5 surgical lead * has fbss and does not require further surgery (defined as persistent or recurrent low back and leg pain of at least 6 months duration following at least one decompression and/or fusion procedure) * average low back pain is ≥ 5 as assessed by the baseline nprs * average low back pain is greater than leg pain * subject has persistent moderate to severe low back and leg pain despite other treatments exclusion criteria: * treated with scs, subcutaneous or peripheral nerve stimulation, an intrathecal drug delivery system, requires back surgery at the location related to his/her original back pain complaint or experimental therapies * most recent back surgery \< 6 months ago * low back pain only (no leg pain) * investigator suspects substance abuse that might confound the study results * radiographic evidence of instability requiring fusion * pain relieved completely by lying down * life expectancy of \< 24 months * subject is pregnant or planning to become pregnant during the course of the study * subject is unable to undergo study assessments or complete questionnaires independently

Keywords: fbss post laminectomy syndrome scs rct back pain
cancer survivor registry: the breast cancer m.a.p. (mind affects the physical) project

Conditions: Cancers

Summary: cancer survivor registry: the breast cancer m.a. p. (mind affects the physical m.a.p.) project to identify and help us understand the emotional and social needs of breast cancer survivors.

the cancer survivor registry: the breast cancer m.a.p. (mind affects the physical) project was the first registry of its kind to look at the emotional and social needs of individuals diagnosed with breast cancer and track how their needs changed throughout their cancer journey. data will raise awareness and help develop programs to address the needs of breast cancer survivors. findings from the registry are disseminated online at www.cancersupportcommunity.org/registryindexreport2017

Eligibility criteria:
inclusion criteria: * having received a cancer diagnosis exclusion criteria: * none

Keywords: cancer cancer survivorship psychosocial needs cancer experience metastatic breast cancer breast cancer caregiver
randomized trial of tinnitus retraining therapy

Conditions: Tinnitus

Summary: millions of americans suffer from tinnitus. however, there is no widely accepted treatment that has been shown to be effective in controlled investigations. the purpose of this study is to evaluate the effectiveness of tinnitus retraining therapy (trt). this study will investigate the contributions of counseling, the use of hearing aids and sound generators, and the importance of setting masking noise to a particular level. all groups will receive the same counseling. in pilot studies we have developed a picture-based counseling protocol. the results of this study will determine if trt is more effective than masking or counseling alone.


Eligibility criteria:
inclusion criteria: * have experienced tinnitus for at least 4 months. * have the ability to participate in research. exclusion criteria: * have a treatable otological disorder. * are involved in litigation. * have or are suspected of having a serious psychiatric problem.
temple health chest initiative (thci 2.0)

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: chronic obstructive pulmonary disease is highly prevalent globally, with considerable morbidity and mortality associated. in the us, it is the 4th leading cause of death, as well as contributing to significant costs on healthcare utilization including hospitalization. population-based screening for copd has not been recommended by the us preventative services task force (uspstf). however, ldct screening for lung cancer in patients aged 50- 80 with ≥ 20 pack year smoking has been shown to improve survival. copd is highly prevalent within lcs programs, with estimated rates of obstructive lung function of up to 59% and evidence of emphysema on ct scan in around 70%.

the rates of undiagnosed copd are reported to be between 20 to 40% 1, 2, 3 with all gold stages of disease identified. of those with no known diagnosis, up to 50% had symptoms consistent with copd1. currently, population-based screening is not recommended for copd by the us preventive services task force (uspstf)4. however, given the overlapping risk factors for copd and lung cancer, there are existing opportunities to target identification of copd within a high-risk group and build further understanding of the impact on outcomes of earlier diagnosis, phenotyping of disease and implementation of treatment. screening for early lung cancer using low dose ct imaging also affords the opportunity to explore presence of comorbidities on images, such as presence and extent of emphysema and other lung parenchymal and airway abnormalities and coronary artery calcification. there is also an opportunity to explore the role of imaging biomarkers for copd such as laa and airway inflammation, in determining risk of disease progression through longitudinal observation.

Eligibility criteria:
inclusion criteria: * 50 to 80 years old * screened for early lung cancer using low dose ct imaging exclusion criteria: * under 50; over 80 years old * no lung cancer screening

Keywords: copd
antiarrhythmic effects of n-3 fatty acids

Conditions: Arrhythmia; Heart Diseases; Tachycardia, Ventricular; Ventricular Fibrillation

Summary: to determine the antiarrhythmic effects of dietary n-3 fatty acids in patients with implanted defibrillators.

background: ventricular tachycardia (vt) and ventricular fibrillation (vf) are common causes of the 300,000 sudden deaths occurring in the united states each year. most of these victims have associated heart disease, most commonly coronary artery disease. populations consuming considerable quantities of fish and marine mammals have lower than expected mortality rates from coronary disease. interventional and observational trials have indicated that fatty fish consumption decreases the death rate from coronary artery disease, in part by reducing the number of sudden deaths. animal and tissue culture studies both support the hypothesis that these beneficial effects are from the antiarrhythmic properties of n-3 long chained polyunsaturated fatty acids (eicosapentaenoic and docosahexaenoic acids). design narrative: prospective, randomized, double blinded trial. survivors of vt and vf with an implantable defibrillator were randomized, 100 to dietary supplementation with n-3 polyunsaturated fatty acids(pufa) or 100 to a placebo. adherence to the supplement were assessed by measurements of plasma, red cell, and adipose tissue n-3 fatty acid concentrations. the primary outcome variable was the incidence of recurrent vt or vf, but secondary variables were also assessed using serial implantable cardioverter defibrillator (icd) assessment, correlation of the rhythms with the biochemical measurements of n-3 fatty acids, hospitalization rates and quality of life. the (icd) was the best protection available to patients and stored rhythm electrograms which allowed documentation of rhythm endpoints. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
male reproduction covid sequelae study (marcos).

Conditions: Infertility, Male

Summary: the purpose of this study is to investigate the effects of covid-19 vaccination on semen parameters and to determine how long these possible changes may last following vaccination.


Eligibility criteria:
inclusion criteria: 1. receiving covid-19 vaccines 2. male age 18-50 years old exclusion criteria: 1. adults unable to consent 2. women 3. prisoners 4. men who have been receiving testosterone replacement therapy or anabolic steroids within the last year 5. men with a history of azoospermia 6. men with a genetic or other medical condition known to be associated with decreased semen parameters (i.e. klinefelter's syndrome, y-chromosome microdeletion (ycmd), post-chemotherapy treatment, etc.) 7. positive covid-19 test within the last 3 weeks

Keywords: covid-19 vaccine
interstitial lung diseases cohort study in china

Conditions: Interstitial Lung Diseases

Summary: in this project, the clinical diagnosis of interstitial lung diseases was carried out for the population with suspected interstitial lung diseases selected from the community cohort, and the confirmed patients were included into the existing clinical cohort of interstitial lung diseases, forming an interstitial lung diseases special disease cohort consisting of 3,000 patients and corresponding matched control groups. according to characteristics of interstitial lung disease and the needs of national key r\&d program of china, this study will formulate unified clinical follow-up strategy to do long-term standardized clinical follow-up in patients with interstitial lung disease. the detailed information for clinical diagnosis and treatment as well as biological samples were collected to identify disease phenotype and build the database and biological sample library for interstitial lung disease cohort study. this study aims to provide evidence for molecular classification, screening and validation of biomarkers as well as precise diagnosis and prevention in patients with interstitial lung disease.


Eligibility criteria:
inclusion criteria: * physician diagnosed ipf during the last 3 months based upon ats/ers/jrs/alat guidelines 2011 * agree to sign the informed consent exclusion criteria: * lung transplantation expected within the next 6 months
efficacy of laser acupuncture on neurophysiological parameters of median nerve in postpartum women

Conditions: Neurophysiologic Abnormality

Summary: background: carpal tunnel syndrome (cts), the most common entrapment neuropathy of the upper extremity, is caused by compression of the median nerve as it travels through the carpal tunnel cts is a very common complication found in pregnancy, which is reported as high as 62% in pregnant females. the functioning of median nerve is compromised in almost all pregnant females especially during the third trimester of pregnancy, the majority may still feel some symptoms up to 3 years after delivery. many clinicians have used lllt on acupuncture points, which is called laser acupuncture (la), to treat many clinical problems, such as musculoskeletal pain, lateral epicondylitis, headaches, etc. in contrast with traditional acupuncture needles, la is a non-invasive therapy that does not cause tingling/pain during procedures objective: to determine efficacy of laser acupuncture on electrophysiological parameters of median nerve in postpartum women

intervention description 1. experimental group: each patient in this group will receive laser acupuncture on pc4 (ximen), pc6 (neiguan), pc7 (daling), pc8 (laogong), li4 (hegu), li10 (shousanli), li11 (quchi), ht3 (shaohai), ht7 (shenmen), lu10 (yuji) acupoints in addition to wearing night splint. la will be applied to each acupuncture point for 10 s with at least 4j/points based on the recommended lllt treatment doses for cts of the world association of laser therapy. 2. control group: each patient in this group will wear night splint every night for 4 weeks

Eligibility criteria:
inclusion criteria: * their bmi will be range from 25 to 30 kg/m2. * the electrophysiological evidence of mild or moderate median nerve lesion at wrist (mild: sensory nerve latency \>3.5 ms at third digit, moderate: sensory nerve latency \>3.5 ms at third digit and median motor latency\>4.2 ms) * positive phalen's test. * positive tinel's test. * carpal tunnel of dominant hand could be participated. exclusion criteria: * history of brachial plexopathy or malignancy. * radial, ulnar neuropathy, proximal median neuropathy or polyneuropathy. * previous wrist surgery or steroid injection for carpal tunnel syndrome. * history of trauma, fracture, deformity or inflammation in the wrist, such as rheumatoid arthritis. * coagulation abnormalities, pregnancy, fever and infections. * skin disease and skin cancer. * spots, birthmarks or tattoos over the work points. 8- pacemaker and implementable medical devices.
remineralization of dentine caries using two remineralizing agents which are nanosilver fluoride and casein phosphopeptides_amorphous calcium phosphate

Conditions: Dental Caries

Summary: the study is randomized controlled trial ...the null hypothesis suggests that there is no significant difference between nanosilver fluoride and sodium fluoride with casein phosphopeptides_amorphous calcium phosphate in the remineralization of dental caries.

the patients will be randomly assigned to one of three study groups the first group is nanosilver fluoride,the second is casein phosphopeptides_amorphous calcium phosphate and the third is sodium fluoride as positive control..the three material will be applied in single application with no repetition ..follow up after one and three month ..the patient should have at least one carious lesion(icdasii code 5)

Eligibility criteria:
* clinical diagnosis of carious lesion * participants should be free of any systemic diseases. exclusion criteria: * sensitivity to silver or other heavy-metal ions or any milk-related allergies and medical conditions involving the kidneys. * the tooth was excluded if it had pulp exposure, abscess/fistula, sensitivity to percussion

Keywords: dental caries remineralization nanosilver fluoride
study to describe risk of bleeding in patients depending on the different anticoagulant therapy they are on for atrial fibrillation (af)

Conditions: Non-valvular Atrial Fibrillation

Summary: study of patients with nonvalvular atrial fibrillation (nvaf) who are newly prescribed noacs (novel oral anticoagulants) in routine clinical practice in england


Eligibility criteria:
inclusion criteria: * diagnosis of atrial fibrillation at or prior to index (the initiation of treatment) * incident prescription of an oral anticoagulant (index date) * patients with at least one year of computerized data prior to index date exclusion criteria: * patients identified with a diagnosis of mechanical heart valve replacement or mitral stenosis identified at any point in the pre-index period in either cprd by read codes or in hes as icd-10/opcs codes * patients with indication of venous thromboembolism (pulmonary embolism or deep vein thrombosis) identified in in either cprd by read codes or hes by icd-10/opcs codes within 3 months prior to index other protocol defined inclusion/exclusion criteria could apply
trial of blue citrus compared to placebo in patients receiving aromatase inhibitor therapy for estrogen receptor positive post-menopausal breast cancer

Conditions: Breast Cancer; Joint Pain

Summary: this purpose of this study is to determine if the herbal compound, blue citrus, decreases joint and bone pain associated with aromotase inhibitor therapy (ait). another purpose of the study is to find out if blue citrus improves how you feel while taking ait and if your quality of life improves.

post-menopausal women currently on ait for breast cancer treatment who self-report musculoskeletal side effects related to ait to their physicians.

Eligibility criteria:
inclusion criteria: 1. post menopausal - evidenced by no menses for the past 6 months or fsh level \>40 2. patient complaints of musculoskeletal symptoms 3. currently taking ait for er positive postmenopausal breast cancer exclusion criteria: 1. previously taken blue citrus 2. presence of bone metastasis 3. unable to complete vas pain scale 4. unable to comply/complete sf 12 quality of life survey 5. plan to discontinue ait in less then six months 6. unable to complete adl scale 7. have diagnosis of fibromyalgia 8. have diagnosis of rheumatoid arthritis

Keywords: breast cancer joint pain aromatase inhibitors