Kornimate/medical-research-clean huggingface dataset:
periodontal treatment with diode laser in the patients with diabetes melitus

Conditions: Diabetes Mellitus; Periodontal Disease

Summary: this study aimed to investigate the effects of diode laser (dl) in addition to non-surgical periodontal treatment on periodontal parameters, systemic inflammatory response, and serum hemoglobin a1c (hba1c) level in patients with uncontrolled type 2 diabetes mellitus (t2dm) and chronic periodontitis.

this study was designed as a randomized, controlled, full-mouth, 6-month clinical trial. 37 patients (20 women and 17 men) with uncontrolled t2dm and chronic periodontitis who were selected from among those admitting to dentistry faculty of inonu university and turgut ozal medical center completed this study. the patients were divided into two groups. the individuals in the control group underwent placebo laser treatment in addition to scaling and root planing (srp). the individuals in the study group underwent dl (1 w power) in addition to srp. clinical index measurements were performed before treatment (t0), 3 months after treatment (t1), and 6 months after treatment (t2). plaque index (pi), gingival index (gi), bleeding on probing (bop), clinical attachment level (cal), and probing depth (pd) were measured to determine periodontal status. hba1c and c-reactive protein (crp) levels were also analyzed using blood samples.

Eligibility criteria:
inclusion criteria: * having a diagnosis of type-2 dm according to the ada criteria for at least two years before the study, hba1c⩾7%,28 * having no change in antidiabetic drugs in the last 3 months, * having no major diabetes complications (because chronic complications of diabetes complicate metabolic control), * presence of generalized cp,29 * presence of an area with a pocket depth of 4-7 mm in at least four teeth in the upper jaw, * presence of at least 20 teeth in the mouth, * having no any systemic illness except for dm, * having no smoke, * receiving no periodontal treatment in the last 12 months, * receiving no antibiotics or anti-inflammatory drugs for a long period in the last 6 months, * not being pregnant or not to breastfeed, * having no third molars. exclusion criteria: -

Keywords: laser periodontal treatment systemic inflammation glycemic control
azoospermia patients

Conditions: Healthy Related

Summary: the prospective cohort study for azoospermia patients was set up to investigate the short- and long-term health consequences in reproductive medical center, first affiliated hospital of zhengzhou university, china.

infertility is an important problem with a multifactorial etiology that affects approximately 15% of couples who attempt pregnancy. its cause in approximately 50% of infertile couples is male factors. spermatogenesis is an extremely complex cell differentiation process involving 2,300 genes that regulate germ cell development and maturation. since last decade, clinical reproductive medicine management system/electronic medical record cohort database (ccrm/emrcd) has been used in reproductive medical center, first affiliated hospital of zhengzhou university, and henan province key laboratory for reproduction and genetics. information of patients (poi, pcos, endometriosis, azoospermia, ect) were recorded comprehensively. the current project plans to recruit azoospermia participants in our center. biological samples, questionnaires and short/long term health data will be collected. the study is aimed to provide evidence for azoospermia prognosis.

Eligibility criteria:
inclusion criteria: * at least three semen evaluations performed on separate occasions, when the seminal specimen after centrifugation showed no sperm under the microscope and was then diagnosed according to several clinical parameters； exclusion criteria: -
impact of ttc following neoadjuvant chemotherapy on the prognosis of lagc

Conditions: Gastric Cancer

Summary: he present study retrospectively analyzed the clinicopathological data of 524 patients diagnosed with lagc who underwent d2 radical gastrectomy after nact between january 2010 and december 2021 at 2 centers. this study was conducted in accordance with the ethical principles outlined in the world medical association's declaration of helsinki. informed consent was obtained from all patients and their legal guardians. all procedures were approved by the institutional review board.

this is a retrospective, multicenter study.

Eligibility criteria:
inclusion criteria: * (1) locally advanced gastric cancer with preoperative clinical staging of ct2-4nxm0 before neoadjuvant chemotherapy. (2) no history of other malignant tumors. (3) no evidence of distant metastasis or invasion of adjacent organs. (4) underwent gastrectomy after receiving neoadjuvant chemotherapy. exclusion criteria: * (1) history of prior gastrectomy. (2) history of acute cardiovascular diseases (such as cerebral or coronary artery injuries) within the past three months. (3) emergency surgery. (4) did not undergo postoperative adjuvant chemotherapy. (5) lack of specific information regarding chemotherapy regimens. (6) loss to follow-up.

Keywords: gastric cancer neoadjuvant chemotherapy adjuvant chemotherapy time to chemotherapy survival
electroacupuncture for poststroke patients with shoulder pain

Conditions: Stroke; Shoulder Pain; Stroke, Complication; Cerebral Infarction; Cerebral Hemorrhage

Summary: this is a multicenter, randomized, sham-controlled, patient- and assessor-blinded, and parallel trial to explore the effectiveness and safety of electroacupuncture (ea) therapy, compared with sham ea, for poststroke shoulder pain.

this study is aimed at showing the effectiveness and safety of electroacupuncture therapy for the stroke survivors with shoulder pain. 60 stroke survivors with shoulder pain will be enrolled in two traditional korean medicine hospitals and randomly divided into either of verum or sham electroacupuncture group with 1:1 of allocation ratio. the participants will receive 9 sessions of electroacupuncture procedures for 3 weeks. patients and outcome assessors will be blinded from the beginning to the study completion. visual analogue scale will be primarily evaluated, and pain rating scale, fugl-meyer assessment upper extremity, modified ashworth scale, manual muscle test, passive range of motion, korean version of modified barthel index, and korean version of beck depression inventory will be measured, too. blinding index will be assessed. for safety, adverse events will be collected.

Eligibility criteria:
inclusion criteria: * diagnosed with cerebral hemorrhage or infarction examined by computed tomography (ct) magnetic resonance imaging (mri) at least 2 weeks or more ago; * complaining hemiplegic shoulder pain of vas ≥4; * agreeing that any treatments, including analgesics, for hemiplegic shoulder pain will not be changed from the previous 2 weeks prior to the enrollment until the last evaluation, if applicable; * fully explained about the clinical research and sign the informed consents. exclusion criteria: * disorders, traumatic injury, or surgery of shoulders even before their stroke; * pacemakers, embedded neural stimulator, cardiac arrhythmia, epilepsy, peripheral neural injury on their medical history; * psychiatric disorders; * cancer within the past 5 years, regardless of its prognosis and location; * cognitive impairment that interferes with clinical assessment; * hypersensitivity or fears to acupuncture; * bleeding disorders (e.g. hemophilia or von willebrand disease, etc.), * pregnancy, * difficulty in communicating with researchers, or * any other conditions who are considered inappropriate for participating in the trial by experienced practitioners.

Keywords: electroacupuncture randomized controlled trial
dilators for dyspareunia prevention

Conditions: Post-operative Dyspareunia

Summary: this is a randomized clinical trial comparing rates of de novo dyspareunia in women with and without vaginal dilator use following surgery for pelvic organ prolapse with traditional posterior repair. our hypothesis is daily use of vaginal dilators from post-op week 4 through week 8 after posterior repair will reduce the rate of de novo dyspareunia.


Eligibility criteria:
inclusion criteria: * women who undergo pelvic organ prolapse surgery with a posterior repair * age ≥18 years * sexually active with heterosexual vaginal intercourse * english speaking * available for 6 month follow up * able to complete study questionnaires * able to use dilators exclusion criteria: * significant baseline dyspareunia * pregnancy by self-report or positive pregnancy test * prior pelvic radiation therapy * active pelvic infection, herpes, candidiasis

Keywords: prolapse pain with intercourse dyspareunia post operative pain
the safety and effectiveness of spc3 in hiv-1 infected patients

Conditions: HIV Infections

Summary: to assess the effects of two doses of synthetic peptide construction 3 ( spc3 ) on hiv-1 plasma levels (as measured by rna pcr amplicor) and on lymphocyte subsets in patients with initial viral load above 10,000 copies/ml. to study the safety of spc3 and the kinetics of hiv-1 plasma level changes.

the first five patients receive spc3 daily for 3 weeks. if that dose is tolerated, the dose is increased and given to the next 5 patients for 3 weeks. the remaining ten patients receive a dose of spc3 based on response to the previous two dose levels. patients are followed through day 28.

Eligibility criteria:
inclusion criteria concurrent medication: allowed: * antiretrovirals provided regimen has been stable for at least 6 weeks prior to study screening. patients must have: * hiv seropositivity for at least 6 months. * cd4 \>= 100 cells/mm3. * hiv rna pcr (amplicor) \> 10,000 copies/ml. * no significant active opportunistic infection or tumor at study entry. fda disclaimer: * the fda encourages the inclusion of females of childbearing potential in study protocols, but the sponsor of this protocol specifically excludes females of childbearing potential from this study and includes only females who are sterile. any questions about these inclusion/exclusion criteria should be directed to the study's contact person. prior medication: allowed: * prior antiretrovirals. exclusion criteria co-existing condition: patients with the following conditions are excluded: inability to communicate with investigator or deemed likely to be noncompliant on study. concurrent medication: excluded: * any drug that may interact with spc3 (e.g., suramin). patients with the following prior condition are excluded: history of relevant drug hypersensitivity. prior medication: excluded: * investigational drug within the past 4 weeks.

Keywords: acquired immunodeficiency syndrome aids-related complex antiviral agents
effect of modified twin block in skeletal class ii growing females with mandibular deficiency

Conditions: Class II Division 1 Malocclusion

Summary: the aim of this study is to evaluate the treatment effects of conventional twin block appliance versus modified twin block appliance in the treatment of patients in growing stage having skeletal class ii division 1 with mandibular deficiency.

in this randomized controlled trail there are 2 groups , the first group will receive modified twin block appliance ,in the second group will receive conventional twin block appliance . the follow up period will be 9 months till mandibular growth occur . the assessment will be through a questionnaire on the number of hours the appliance is worn each day , and another questionnaire assessing the difficulty of speech and aesthetics . also by, photographs, x-rays and study models preoperative and post operative.

Eligibility criteria:
inclusion criteria: 1. skeletal class ii relationship (anb \> 4°). 2. mandibular retrognathy (snb \< 78°). 3. overjet ≥ 5 mm. 4. minimal crowding in dental arches (≤4 mm). 5. class ii molar relation. 6. growing female patients. 7. patients with cmv3 maturation stage of the cervical verbrae. exclusion criteria: 1. no history of orthodontic treatment either prior to or during functional appliance therapy. 2. posterior cross bites or severe maxillary transverse deficiency. 3. severe facial asymmetry determined by clinical or radiographical examination. 4. poor oral hygiene. 5. systemic diseases that may affect the orthodontic treatment results. 6. patients past their peak growth spurt.
the impact of psychological interventions on psychometric and immunological measures in patients with major depression

Conditions: Depression

Summary: the objective of this study is to compare the impact of i) cognitive behavioral therapy (cbt) combined with exercise, ii)cbt combined with euthymic therapy, and iii) 'cognitive behavioral analysis system of psychotherapy' (cbasp) on psychometric and immunological measures in patients with major depression.

the interest of the investigation is to compare the impact of cbt combined with exercise, cbt combined with euthymic therapy and cbasp on depression and further psychopathological variables (assessed at 5 points). previous findings indicate increased concentration of pro-inflammatory cytokines in depression. a bidirectional relationship between depression and immunological alterations has been suggested: on the one hand pro-inflammatory cytokines may contribute to depression, on the other hand depression-linked changes (e.g. a reduction of activity, increased stress-sensitivity) may lead to increased secretion of pro-inflammatory cytokines. therefore, this study is also supposed to investigate the influence of above mentioned interventions on pro-inflammatory cytokines. using a waiting group, potential changes in psychometric and biological parameters without any intervention are controlled. assessments take place at baseline, after 4 weeks of treatment, after 8 weeks of treatment, after 16 weeks of treatment and 6 months follow up. 200 patients with major depression (dsm iv, bdi ii at baseline ≥18) will be included. patients will be randomized and assigned to one of the 4 groups.

Eligibility criteria:
inclusion criteria: * patients with major depression (dsm iv), bdi \>=18 * age:18-65 years * patients with and without antidepressive medication * comorbidity with other psychiatric disorders is permitted, as far as depressive symptoms are dominating exclusion criteria: * current psychotherapy * psychotic disorder * serious drug-addiction * drugs which seriously affect immune status (except contraceptives) or central nervous system functions (except antidepressants) * infections during the last 2 weeks * injuries during the last 2 weeks * neurological disorders * diseases which affect immune status or central nervous system functions (e.g. rheumatoid arthritis, cvd,etc.)

Keywords: depression exercise psychoneuroimmunology cognitive behavioral therapy cbasp
grape pomace polyphenols and cardiometabolic risk

Conditions: Subjects at Cardiometabolic Risk

Summary: the aim of this is study is to evaluate the long-term effects of grape polyphenols in the modulation of markers of metabolic syndrome. most of the previous works about polyphenols have only considered a fraction of polyphenols, i.e., extractable polyphenols. as a consequence, an important amount of dietary polyphenols, the so-called non-extractable polyphenols are ignored. in contrast, the effect of both extractable and non-extractable polyphenols will be considered in this study. also, studies on the long-term effect of grape polyphenol on markers of metabolic syndrome have been mostly conducted in animals, so clinical trials on this topic are needed.

fifty supposedly healthy volunteers with at least two cardiometabolic risk factors were recruited. the cardiometabolic risk factors used to select the subjects are described below. the whole intervention will be divided in 2 periods, control (ctr) and dried and milled grape pomace (grapom). the two periods will have a duration of 6 weeks. during the ctr period, subjects will follow their normal dietary habits and samples will be collected at the beginning and at the end. no proper placebo could be found for the product, so this ctr period was chosen. during the grapom period, the subjects will daily consume 8 g of the product solved in water and samples will be collected at the beginning and at the end.

Eligibility criteria:
inclusion criteria: at least two of the following requirements: * bmi ≥ 25 kg/m2. * fasting glucose values ≥ 100 mg/dl. * triglycerides ≥ 150 mg/dl. * hdl-cholesterol: ≤ 50 mg/dl women, ≤ 40 mg/dl men. * blood pressure: systolic ≥ 130 mm hg or diastolic ≥ 85 mm hg. exclusion criteria: * subjects with a pharmaceutical treatment set to modify blood pressure, lipid profile or glucose. * volunteers participating in other studies or weight loss plans. * pregnant or breastfeeding women.

Keywords: polyphenols metabolic syndrome cardiometabolic risk grape pomace postprandial glucose insulin resistance obesity
acute otitis media: adjuvant therapy to improve outcome

Conditions: Otitis Media

Summary: acute otitis media is one of the most common diseases of childhood and is one of the major causes of hearing loss in children. despite the availability of effective antibiotic therapy for otitis media, treatment failures, persistent effusions, and recurrences are common. this phase iii outpatient study aims to test whether adjuvant therapy (an antihistamine or a corticosteroid), in addition to antibiotic therapy, improves the acute and long-term outcomes of patients with acute otitis media. this study is targeted to recruiting 200 infants (age less than one year); patient (and parent) participation is estimated to continue for one year after enrollment.


Eligibility criteria:
inclusion criteria: * have had two documented prior episodes of acute otitis media. * have no current middle ear effusion (fluid). exclusion criteria: * have chronic otitis media. * have acute otitis media in addition to chronic otitis media.

Keywords: antibiotics adrenal cortex hormones histamine h1 antagonists infant otitis media
massive individualized n-of-1 experiments (mines)

Conditions: Stress, Psychological; Happiness; Cognition

Summary: the project will enroll up to 10,000 adult volunteers in individualized experiments (n-of-1 trials) designed to assess the individual-level effects of any of five interventions on three outcomes. the five interventions are: gratitude journaling, mindfulness meditation, random acts of kindness, physical activity, and laughter therapy. the three outcomes are stress, cognitive focus, and happiness. each participant will engage in the selected activity in 3 day intervals, separated at random by 3 day intervals of usual activity, for a total of six 3-day periods (18 days).

n-of-1 trials (single patient crossover experiments) are a uniquely powerful technique for estimating treatment effects in the individual. n-of-1 trials have been offered to hundreds or perhaps thousands of patients worldwide, but never at scale. hackyourhealth is a tool that supports the conduct of simple n-of-1 self-experiments to test if healthy activities that work in general (i.e., mindfulness meditation, physical activity, gratitude journaling, random acts of kindness, and laughter therapy), improve psychological well-being (stress, focus, happiness) in specific individuals. the tool supplies the experimental design, facilitates data analysis, and channels feedback to participants. the tool is flexible enough to support massive individualized n-of-1 experiments (mines) at scale. working with wnyc radio in new york city, we will recruit and run 18-day n-of-1 trials up to 10,000 individuals. the purpose of this study is to conduct a formative evaluation of hackyourhealth in terms of its perceived usefulness and to explore heterogeneity in intervention response across the sample. we anticipate that the results will: 1) identify useful behavioral interventions for individual participants; 2) help to estimate generalizable treatment effects for the interventions of interest; 3) assess heterogeneity of treatment effects across subgroups; and 4) elucidate the user experience with n-of-1 trials. when complete, the study will support additional proposals designed to assess the utility of mines as applied to additional conditions and treatments.

Eligibility criteria:
inclusion criteria: * age 18 or over * living anywhere in the united states * using a smartphone * having regular access to internet on their phone * able to read and write in english exclusion criteria: there are no exclusion criteria, except that patients with pre-existing cardiovascular disease will be cautioned not to engage in new types of physical activity without consulting a physician.
contact lens wettability

Conditions: Ametropia

Summary: the purpose of this study is to compare the wettability of contact lenses disinfected with three marketed contact lens care solutions.


Eligibility criteria:
inclusion criteria: 1. has had an oculo-visual examination in the last two years. 2. is at least 18 years old and has full legal capacity to volunteer or is at least 16 years old, has a parent or guardian's permission to participate in the study and has read the information and consent letter for adolescents. 4. has read and understood the information consent letter (appendix ii). 5. is willing and able to follow participant instructions for product usage and meet the protocol-specified schedule of follow-up visits. 6. has a refractive error that is correctable with the prescription of the available study lenses. 7. has a refractive error that is correctable to at least 20/25 distance visual acuity with contact lenses in each eye. 8. has acceptable fit with the study lenses. 9. has clear corneas, and ocular clinical findings are considered "normal". exclusion criteria: 1. has any systemic disease that may affect ocular health. 2. is using any systemic or topical medications that may affect ocular health. 3. has any ocular pathology or severe insufficiency of lacrimal secretion (dry eyes) that may affect the wearing of contact lenses. 4. has any clinically significant lid or conjunctival abnormalities, meibomian gland dysfunction, neovascularization, corneal scars or corneal opacities. 5. has limbal injection, bulbar injection or corneal staining that, in the investigator's opinion, is clinically significant. 6. has pinguecula and/or pterygium that, in the investigator's judgement, makes contact lens wear inadvisable. 7. has refractive astigmatism of more than 0.75 d. 8. has corneal distortion resulting from rigid lens wear. 9. is aphakic. 10. has undergone corneal refractive surgery. 11. is participating in any other type of clinical or research study. 12. is pregnant or lactating.