Kornimate/medical-research-clean huggingface dataset:
efficacy, safety, and tolerability of avp-786 for the treatment of negative symptoms of schizophrenia

Conditions: Schizophrenia

Summary: this study will be conducted to evaluate the efficacy, safety, and tolerability of avp-786, as compared with placebo, for the treatment of negative symptoms of schizophrenia.


Eligibility criteria:
inclusion criteria: * participants who meet the diagnostic and statistical manual of mental disorders, 5th edition (dsm-v) diagnostic criteria for schizophrenia confirmed by the mini international neuropsychiatric interview (m.i.n.i) version 7.0.2 * participants must have well-controlled positive symptoms and prominent negative symptoms as defined by positive and negative syndrome scale (panss) criteria. * participants currently receiving a second-generation atypical antipsychotic drug (sga) are eligible if they are stable and adherent to their dosing schedule. * participants must have a reliable informant (e.g., case manager, social worker, family member). the informant should be able to spend an adequate amount of time with the participant to be able to address behaviors, activities, and symptoms. exclusion criteria: * participants with current major depressive disorder (mdd) * participants with pseudo-parkinsonism secondary to their ongoing antipsychotic medication * participants currently using anticholinergic medications * participants recently hospitalized as in-patients

Keywords: negative symptoms schizophrenia avp-786
satraplatin in hormone refractory prostate cancer patients previously treated with one cytotoxic chemotherapy regimen

Conditions: Prostate Cancer; Hormone Refractory Prostate Cancer

Summary: purpose: the sparc trial is designed to compare the combination of the investigational oral cytotoxic drug, satraplatin, and prednisone, versus prednisone alone as second line chemotherapy in patients with hormone-refractory prostate cancer (hrpc). target patient population: the sparc trial is intended for patients who have hormone-refractory prostate cancer (hrpc) and whose disease has progressed after treatment with one chemotherapy regimen. please refer to the eligibility criteria page for the key inclusion and exclusion criteria. what is satraplatin: satraplatin is a member of the platinum-based class of chemotherapy drugs. platinum-based drugs have been clinically proven to be one of the most effective classes of anticancer therapies. unlike the currently marketed platinum-based drugs, satraplatin can be given orally. satraplatin is also the only platinum-based drug that has demonstrated efficacy against prostate cancer in a randomized trial. rationale: there are currently no approved chemotherapy drugs for the second line treatment of hormone-refractory prostate cancer (hrpc). in a preliminary randomized trial conducted in europe, the combination of satraplatin and prednisone had superior activity compared to prednisone alone, for the treatment of hrpc patients who had not previously been treated with chemotherapy


Eligibility criteria:
inclusion criteria: * stage d2 metastatic prostate cancer * progression after one prior chemotherapy * ecog performance status equal / less than 2 * life expectancy \> 3 months * surgical or medical castration * adequate bone marrow, hepatic and renal functions * informed consent exclusion criteria: * more than one prior chemotherapy * prior platinum containing compounds * prior malignancy * prior significant rt/radionuclide therapy * major gi surgery or gi disease affecting absorption * disease with contraindication to steroids * brain metastases

Keywords: prostatic neoplasms cancer treatment protocols antineoplastic protocols one prior cytotoxic chemotherapy regimen
comparison between preterm infants who are placed on their back or stomach in the immediate postextubation period

Conditions: Pregnancy Preterm

Summary: the purpose of this study is to determine whether patient positioning (prone and supine positioning) contributes to the success of extubation in the immediate postextubation period of preterm infants.

this study is double-blinded randomized controlled trial, whose aim is to compare the proportion of successful extubation of preterm infants immediately after the extubation. methods: participants will be recruited from neonatal intensive care unit (nicu) and they will be divided into two groups (supine and prone) and positioned in their respective groups after extubation. a clinical evaluation form and a parameters collection form (respiratory rate, heart rate, saturation of peripheral oxygen, fraction of inspired oxygen and temperature) will be used and filled before extubation and 48 hours after by the professional staff of the nicu. it will be considered a successful extubation all participants who staying extubated for 48 hours after extubation.

Eligibility criteria:
inclusion criteria: * newborns less than 37 weeks of gestation age (calculated by doctor using the method of capurro/ballard) * newborns undergone to invasive mechanical ventilation in the first week of life, for more than 48 hours exclusion criteria: * newborns who present malformations and clinical or surgical conditions that preclude the positioning in prone or supine after extubation

Keywords: patient positioning premature infant mechanical ventilation airway extubation
prevalence of covid-19 infection in a cohort of patients infected by the hiv and patients taking prep

Conditions: Covid19; Virus-HIV

Summary: the purpose of the study is to assess seroprevalence of covid-19 infection in a cohort of hiv + patients and in a cohort of patients taking prep by emtricitabine / tenofovir.


Eligibility criteria:
inclusion criteria: * aged ≥ 18 years * patients infected by the hiv on treatment * patients taking prep (pre-exposure prophylaxis (prep)) * being affiliated with or benefiting from a social security scheme exclusion criteria: * subject to a measure for the protection of justice
a 12-week study to evaluate the efficacy of darifenacin to increase the warning time in patients with overactive bladder.

Conditions: Overactive Bladder Syndrome

Summary: this study will assess the efficacy of a 12-week treatment with darifenacin in increasing warning time, the time from first sensation of urgency to voiding, in patients with oab.


Eligibility criteria:
inclusion criteria: * three symptoms of oab (urge incontinence, frequency and urgency) for at least six months prior to visit 2. * patients capable of independent toileting and able of independently completing the patient diary. exclusion criteria: * patients in whom the use of anticholinergic drugs was contraindicated * evidence of severe liver disease * patients with other clinically significant urinary or gynecological conditions other protocol-defined inclusion/exclusion criteria may apply.

Keywords: overactive bladder, incontinence, antimuscarinic, warning time, darifenacin
myhealthhub for older adult inpatients

Conditions: Patient Engagement; Stress; Loneliness; Quality of Life

Summary: this study will assess "myhealthhub" in hospitalized older adults throughout 5 days of their hospital stay. the investigators propose a mixed method randomized controlled trial (rct) comparing myhealthhub platform vs. a simplified healthhub system that provides only tv access, in order to evaluate patients' loneliness, stress, quality of life, patient engagement, and other mental health outcomes in n=60 older adult inpatients. the investigators will also use qualitative methods to assess user and stakeholder experience, and engagement.


Eligibility criteria:
quantitative component: inclusion criteria: * ≥60 years old * admitted to non-surgical hospital unit * speak english or french * capable of giving consent exclusion criteria: * delirium * active suicidal ideation * moderate/severe dementia diagnosis qualitative component: inclusion criteria: * participants from quantitative component * hospital staff, nurses, clinicians facilitative use of the service * ≥18 years old * speak english or french exclusion criteria: • hospital staff, nurses, clinicians who do not have experience with the service

Keywords: older adults hospital inpatients technology
impact of meal order on postprandial cardiometabolic risk markers

Conditions: Metabolic Syndrome X; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Summary: the order in which the different components of a meal are eaten may have impact on the postprandial metabolic responses to carbohydrates, fat and proteins. this study will compare blood lipids and glycemia regulation following lunches of identical composition but varying the order of intake of the different meal components.

the order in which the different components of a meal are eaten may have impact on the postprandial metabolic responses to carbohydrates, fat and proteins. some of these responses are associated with the risk for developing cardiometabolic complications. the study will be carried out in a cohort of healthy subjects with a wide bmi range and normal fasting glycemia. postprandial metabolic responses to a reference meal starting with bread and butter (bb) will be compared with those registered after 3 other meals of identical composition, in which the starter will be permutated. each meal is tested on an independent experimental session, with a 1 week washout interval. the intervention will be carried out at the food for health science centre - lund university. additionally, the plan contemplates an initial information visit including screening of fasting blood glucose. in total, each volunteer completing the study will pay five visits to the clinical unit. based on the results from the above-described phase, a second step of the study will compare various quality attributes of the most effective starter on the impact on cardiometabolic risk markers, as a way to optimize putative protective actions and to gain further mechanistic insight.

Eligibility criteria:
inclusion criteria: * bmi between 20 and 30 kg/m2 * fasting blood glucose ≤ 6.1 mmol/l * no known medical condition exclusion criteria: * smoking habits * treatment for high blood pressure * treatment for hypercholesterolemia

Keywords: type 2 diabetes risk cardiovascular disease risk
physical activity levels of hypertensive and healthy individuals under social isolation during the covid-19 pandemic

Conditions: Hypertension; Social Isolation; COVID

Summary: covid-19 is an emergency situation which broke out from china in 2020. health commitees and goverment set some rules and limit people's freedom to leave from their houses and it is called as 'social isolation'.staying at home and disease bring about sedentary lifestyle, anxiety and depression and changed eating habits of all person. hypertension is an important cardiovasculary risk factor and physical activity, stress managament are very important for disease control. in that study we aimed to assess hypertensive and healthy person's anxiety level, physical activity and qualit of life level during covid-19 social isolation.

covid-19 is an emergency situation which broke out from china in 2020. health commitees and goverment set some rules and limit people's freedom to leave from their houses and it is called as 'social isolation'. with social isolation people were restricted to go outside from house and with that they had to stay at home. staying at home and disease bring about sedentary lifestyle, anxiety and depression and changed eating habits of all person. it was very dangerous especially chronically ill persons. physical activity and exercise are keystones for managing cardiovasculary disease risk factors. hypertension is important risk factor all around the world. disease control is important to prevent complications. in that study, we aimed to assess hypertensive and healhty individuals' physical activity, anxiety, healthy lifestyle habits and quality of life with changed life condition during covid-19 social isolation.

Eligibility criteria:
inclusion criteria: * social and occupational restriction because of covid-19 pandemic * not having speech and hearing problems * to be cooperate * not having mental, neurological, orthopedic, cardiovascular or pulmonary problems that prevent physical activity exclusion criteria: * presence of medical indications requiring complete restriction of physical activity * having symptoms of covid-19 and suspected disease * coronavirus infection in the past month * concomitant history of cardiovascular disease

Keywords: physical activity hypertensive anxiety quality of life
international caps registry: pancreas cancer cases in surveillance programs

Conditions: Pancreas Cancer

Summary: various centers around the world are currently investigating the feasibility and yield of surveillance for pancreatic cancer in high-risk individuals. evidence is beginning to accumulate that surveillance may lead to the early detection of non-invasive precursor lesions and asymptomatic early stage cancer. ultimately, the goal of surveillance is to reduce mortality in these high risk individuals, but before this can be confirmed many research questions need to be answered. while the numbers of high-risk individuals screened in each separate screening facility are likely too small to properly address many of these questions, pooling data comprises a sizable sample size providing unique research opportunities. the objective of this study is retrospectively review all cases of high-risk individuals participating in our pancreatic surveillance program in whom 1) a suspicious precursor lesions was detected for which a pancreatic resection was performed and 2) in whom an advanced malignant disease was diagnosed. the de-identified information will be entered into an international multicenter database registry.

the study is a retrospective review of all cases of high-risk individuals participating in our pancreatic surveillance program in whom 1) a suspicious precursor lesions was detected for which a pancreatic resection was performed and 2) in whom an advanced malignant disease was diagnosed. the de-identified information will be entered into an international multicenter database registry.

Eligibility criteria:
inclusion criteria: * elevated pancreas cancer risk cohort with pancreas cancer or dysplastic pancreas changes exclusion criteria:

Keywords: familial pancreas cancer pancreatic cyst
the effect of gnrh agonist administered in the luteal phase on art cycle outcomes

Conditions: Infertility

Summary: this prospective clinical trial evaluates the effect of a two dose gnrh agonist administered in the luteal phase on the outcome of art cycles stimulated with the long gnrh agonist and gnrh antagonist protocol.

this prospective clinical trial evaluates the effect of a two dose gnrh agonist administered in the luteal phase on the outcome of art cycles stimulated with the long gnrh agonist and gnrh antagonist protocol. decision between each of these two protocols was subjective and depended on the clinical context.in addition to routine luteal phase support with progesterone and estradiol valerate,women received two dose of gnrh agonist on the fifth and tenth day after et.live birth rate was the primary outcome measure.

Eligibility criteria:
inclusion criteria: * couples undergoing art with their own gametes. * couples having at least one good embryo available for transfer. * normoresponder * infertility etiology is unexplained * ovulation triggered by intramuscular injection of 10000 iu of hcg exclusion criteria: patients older than 38 years old * high and poor responder patients

Keywords: luteal phase support,gnrh agonist,art cycles
cardiac dysfunction in obstructive sleep apnea patients: prevalence of and effect of ncpap

Conditions: Sleep Apnea

Summary: the aim of this study is to clarify the influence of obstructive sleep apnea syndrome on left ventricular function using echocardiographic parameters including the myocardial performance index (tei-index), and to determine the short-term effects of ncpap on them.

obstructive sleep apnea syndrome (osas) affects 2% and 4% of middle-aged women and men respectively, and is associated with an increased risk of cardiovascular complications. therefore, cardiovascular consequences must be evaluated in the clinical management of osas and the study of cardiac functional parameters could be particularly useful. reported findings are conflicting with respect to the influence of osas and nasal continuous positive airway pressure (ncpap) on left ventricular function. in this study, we assess cardiac dysfunction with echocardiographic parameters, such as lvef, left ventricular mass, ratio of e to a (e/a) and mitral deceleration time (dt) from the mitral inflow velocity, and tei-index, or plasma brain natriuretic peptide (bnp) level at baseline, and 1 and 3 months after ncpap treatment. the main endpoint is the comparison of echocardiographic parameters and bnp between osas patients and control subjects, and the changes of them after short-term of ncpap treatment.

Eligibility criteria:
inclusion criteria: * osas patients: moderate to severe osas patients with apnea-hypopnea index (ahi) ≥ 20 events/hour by overnight polysomnography and start ncpap treatment. exclusion criteria: * apparent lung diseases * daytime hypoxemia (pao2 \<80 mmhg) * atrial fibrillation, bundle branch block, atrioventricular block and implantable pacemaker * left ventricular dysfunction (ejection fraction \<50%) * ischemic or valvular heart disease, and cardiomyopathy determined from medical history or a physical examination, electrocardiogram (ecg), chest radiography, and echocardiography * renal insufficiency (serum creatinine \>2.0 mg/dl).

Keywords: sleep apnea continuous positive airway pressure echocardiography natriuretic peptide
compare propofol to fentanyl and midazolam for colonoscopy

Conditions: Colon Cancer; Rectal Cancer; Colonic Diverticulosis

Summary: the study aim is to determine if propofol or the combination of fentanyl and low-dose midazolam, are equivalent for patient satisfaction and discomfort when undergoing a colonoscopy. this is a prospective randomized study of 262. the primary outcome of this study is participant's satisfaction and discomfort of the colonoscopy procedure as perceived by the participant, and the secondary outcome will be the discomfort of the patient and difficulty of the procedure as perceived by the physician.

background the use of colonoscopy has become an important diagnostic and therapeutic tool in the evaluation of multiple medical conditions of the gastrointestinal tract. despite its widespread use, there continues to be debate concerning the best pharmacologic approach to patient satisfaction and discomfort of the procedure and to minimize side effects. aim two standard pharmacologic (propofol or fentanyl and low-dose midazolam) approaches for colonoscopy will be evaluated systematically to determine if these two approaches are equivalent in terms of patient rating of satisfaction and patient discomfort to the procedure and side effects study design this is a prospective randomized study of 262 participants undergoing outpatient colonoscopy at an independent academic medical center. the primary outcome of this study is participant's satisfaction, and the secondary outcome is discomfort of the patient as perceived by the physician performing the procedure. other variables of interest. * duration of procedure as defined by time the patient arrives in the room to the time the patient is appropriate for discharge. * difficulty of procedure rated by the physician on a scale of 0-10 * colonoscopy completion rates (intubation of cecum). * complications including oxygen desaturation or hypotension. * cost of the two medication regiments

Eligibility criteria:
inclusion criteria: * age \> 18 * elective outpatient colonoscopy * american society of anesthesiology class (asa) \< iv exclusion criteria: * age \< 18 * inpatient status * emergency procedure * history of colonic or rectal resection * history of hypersensitivity to propofol (or soy or egg products),fentanyl or midazolam * asa of iv * neurological deficit * acute gastrointestinal bleeding * on anticoagulation agents * noncompliance with bowel regiment * pregnant women * prisoners

Keywords: colonoscopy propofol cancer screening
pt vs no pt following tha

Conditions: Osteoarthritis

Summary: the purpose of this study is to determine if outpatient physiotherapy results in improved and/or more rapid achievement of functional outcomes and quality of life in comparison to those patients who do not undergo outpatient physiotherapy after total hip arthroplasty


Eligibility criteria:
inclusion criteria: * any patient undergoing unilateral primary total hip arthroplasty with age \> 60 exclusion criteria: * post-traumatic osteoarthritis * rheumatoid arthritis or other peripheral inflammatory disease * avascular necrosis * revision or conversion tha * post-septic osteoarthritis * patients discharged to a rehabilitation unit or other form of respite care such as a skilled nursing facility, acute rehabilitation center, convalescent home, long-term care facility or nursing home
female chronic pelvic pain

Conditions: Pelvic Pain; Abdominal Pain; Painful Bladder Syndrome; Interstitial Cystitis; Irritable Bowel Syndrome

Summary: the purpose of this study is to investigate the frequency and severity of chronic pelvic pain (cpp) in adult women living in copenhagen country and zealand country (total population 2,4 million), denmark, in relation to selected factors, such as basic demographic and clinical factors, health related quality of life, physical activity and abnormal muscular findings in the pelvic area.

introduction: the aim of this study is to investigate the frequency and severity of chronic pelvic pain (cpp) in adult women living in copenhagen country and zealand country (total population 2,4 million), denmark, in relation to selected factors, such as basic demographic and clinical factors, health related quality of life, physical activity and abnormal muscular findings in the pelvic area. methods: the study is designed as a cross-sectional, questionnaire-based survey and two randomly selected age stratified groups of the responding participating women, one with or one without pain, will receive a clinical examination by a specialist physiotherapist for abnormal muscular finding in the pelvic, lower abdominal or inguinal area. results: descriptive characteristics will be obtained by univariate analysis and presented as means with standard deviations, or percentages. t test and the mann-whitney test will be used to analyze continuous data with and without normal distribution, respectively, and the chi-square test or fisher's exact test will be used to analyze categorical data, as appropriate. correlation between self-reported cpp and abnormal muscular findings will be analysed. logistic regression analysis will be used to identify the independent variables significantly associated with cpp. for logistic regression analysis, we will select only those findings that are significant as determined by fisher's exact or the chi-square test, with values of 0 and 1 assigned to the absence and presence, respectively, of each variable in each subject.

Eligibility criteria:
inclusion criteria: * women ≥ 18 years * living in copenhagen country (region h) * capable of reading, writing and speaking danish exclusion criteria: * pain limited solely to the perineal skin or introitus (vulvodynia) * pregnancy, cancer, active pelvic inflammatory disease * operation in the pelvic during the last 6 months * cognitively impaired individuals

Keywords: physiotherapy multidisciplinary pain centers pain measurements physical activity quality of life