Kornimate/medical-research-clean huggingface dataset:
application and comparison of fuzzy scale for the evaluation of pain skeletal muscle with the numerical pain scale

Conditions: Pain

Summary: this study aimed to analyze the stratification of pain levels through a mathematical model built using the diffuse joint theory and to investigate the relationship between range of motion and pain related aspects.

the incidence of pain is due to traumatic actions, surgical interventions, new habits of life, increased longevity of the individuals and the reduction of the tolerance of the suffering by the man. musculoskeletal pain is more evident in adult individuals, being the main cause of chronic pain throughout society, generating an impact on the quality of life, interfering in the daily activity of 30 to 50% of the patients. pain measurement can be divided into four levels, which include the nominal, the ordinal, the interval and the ratio, with both one-dimensional and multidimensional versions. in the health area, diagnosis and treatment of diseases involve various levels of imprecision and uncertainties. a single disease or symptom may manifest totally differently in different patients and with varying degrees of severity. these effects usually generate many uncertainties and inaccuracies affecting the interpretations of the exams and the diagnosis, as well as the treatment. fuzzy systems theory, also known as nebulous logic, is used to interpret the approximate mode of human reasoning, to take it to a numerical format and to obtain answers in an environment of uncertainties that serve as a subsidy to decision-making . a fuzzy system based on fuzzy logic. it can also be considered as a kind of expert, knowledge-based system. the development of the proposed fuzzy scale for skeletal muscle pain evaluation used the mamdani method that allowed the representation of specialist knowledge (s) to construct the rule base. the construction of this system was based on the numerical scale of pain adopted and spread worldwide, and on the range of motion represented by the action of the muscles and articular components of the human body. the diffuse model proposed by the fuzzy scale for muscle skeletal pain evaluation uses 25 rules using binary xor logic. for the volunteer tests, the proposed model was a non-randomized single intervention transverse study to analyze and compare the model of diffuse pain evaluation with the numerical pain scale performed with 535 volunteers.

Eligibility criteria:
inclusion criteria: * included in this study were male and female subjects * age between 18 and 90 years * with complaint of skeletal muscle pain * do not present cognitive deficit that makes the study impossible exclusion criteria: * individuals who did not agree to participate in the study * volunteers with decreased range of motion * volunteers without complaint of skeletal muscle pain

Keywords: evaluation of pain fuzzy systems theory
isoflurane at subanesthetic concentrations - 6

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Summary: the purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. to test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.


Eligibility criteria:
please contact site for information.

Keywords: isoflurane general anesthetic inhalant subjective effects healthy volunteer
safety study of dexmedetomidine in septic patients

Conditions: Sepsis; Agitation

Summary: septic patients in intensive care unit always need mechanical ventilation and conscious-sedation. but the recommended dose 0.2-0.7μg/kg/h could not run well because of wide range. the purpose of this study is to find the effective dose of dexmedetomidine adult septic patients of mechanical ventilation .

inclusion criteria: age: between 18 years mechanical ventilation rass≥2 a diagnosis of sepsis within 48 hours exclusion criteria: cardiac disease cardiac rhythm abnormalities liver dysfunction coma severe hypotension muscle relaxant users primary outcome measures: dose of dexmedetomidine secondary outcome measures: rass score requirement for rescue intervention, rass will be recorded per hour.

Eligibility criteria:
inclusion criteria: * intubated patients rass≥2 a diagnosis of sepsis within 48h exclusion criteria: * cardiac disease cardiac rhythm abnormalities liver dysfunction coma severe hypotension muscle relaxant users
web-based interactive health communication application (ihca) for successful home dialysis

Conditions: Chronic Kidney Disease

Summary: this study involves chronic kidney disease patients that must choose the type of dialysis therapy they ultimately wish to perform. these patients receive education regarding dialysis types from nurses and nephrologists at a kidney function program. the investigators have developed a web-based interactive health communication application that could provide more education and support to patients about their dialysis choices. the investigators will compare patients that will receive usual care dialysis education versus patients that will receive additional education through this web-based application. the investigators feel that this tool may increase the proportion of patients who start home dialysis, which offers advantages such as improvement in quality of life and deceased overall healthcare costs, over hospital hemodialysis.


Eligibility criteria:
inclusion criteria: * enrolled in kidney function program (kfp) * previously received kfp-administered dialysis modality education * personal access to a home computer (ie. either their own or a close friend/family member) with internet access * most recent egfr \< or = 20ml/min/1.73m2 exclusion criteria: * inability to provide informed consent * inability to use a home computer or internet * inability to understand english (written or spoke) * severe visual or auditory impairment

Keywords: chronic kidney disease web-based application dialysis education
glaucoma assessment via reading ability

Conditions: Glaucoma, Primary Open Angle

Summary: to explore a quantitative glaucoma evaluation tool of glaucoma through the dynamic evaluation of reading ability based on logarithmic chinese reading acuity chart (c-read), and investigate its feasibility.

glaucoma is the most common cause of irreversible blindness in the world, and it's marked by the gradual loss of retinal ganglion cells and their optic nerve fibres. early detection and treatment can successfully prevent the disease's development and prevent blindness. glaucoma sufferers' near visual qualities, particularly their ability to read, might be compromised. patients can, however, regain some comfortable reading capacity following glaucoma therapy. the logarithmic chinese reading acuity chart (c-read) can be beneficial as a tool for functional vision evaluation, and there is rising clinical interest in this well-standardized, calibrated reading chart. reading chart standards that allow for equal assessment of reading factors such as acuity and speed are currently lacking. the c-read approach as a judge of glaucoma patients' status lacks theoretical support, and functional visual evaluation tools are still in their infancy. therefore, we want to complete these tasks: 1) develop a dynamic analytic system and improve the evaluation criteria for the c-read testing procedure; 2) confirm the usefulness of c-read for early glaucoma screening through clinical studies. c-read will provide a reliable and cost-effective screening technique that is convenient, affordable, and noninvasive.

Eligibility criteria:
inclusion criteria: * primary open angle glaucoma in at least 1 eye or labelled as a glaucoma suspect by a glaucoma specialist * age ≥18 years old * with open angles on gonioscopy * best-corrected visual acuity ≥0.5 * spherical refraction within ±5.0 diopters (d), and/or cylinder correction within 3.0 d exclusion criteria: * eyes with any evidence of physical abnormality of the iris or pupils on slit-lamp examination * eyes with a history of trauma or inflammation * undergone an intraocular surgery or laser within the previous 6 months/except uncomplicated cataract surgery * using systemic or topical medications that could affect pupil responses, including pilocarpine or atropine * presence of any media opacities that prevented good quality oct or fundus images * presence of any retinal or neurological disease other than glaucoma * abnormal ocular motility that prevents binocular fixation (eg, nystagmus, strabismus) * with severe systemic diseases or psychiatric disorders
novel imaging approaches to identify unstable coronary plaques

Conditions: Coronary Artery Disease

Summary: cardiovascular disease is the leading cause of death in scotland and the western world. approaches to improve the identification of vulnerable or ruptured coronary atherosclerotic plaques are urgently needed to help risk stratification, to identify patients for intensive therapies, and to provide novel biomarkers for the development of anti-atherosclerotic drug interventions. using positron emission tomography, we have recently shown that sodium 18-fluoride uptake holds major promise as a novel marker of plaque vulnerability and rupture. here we wish to characterise coronary atherosclerotic plaque using 128-multidetector computed tomography combined with 18-fluorodeoxyglucose and sodium 18-fluoride positron emission tomography and virtual histology-intravascular ultrasound in 80 patients with stable and unstable coronary artery disease. this has the potential to provide an innovative and highly valuable translational model with which to test novel therapeutic interventions targeted at reducing atheroma and plaque rupture. this could have major implications for the future treatment of cardiovascular disease.


Eligibility criteria:
inclusion criteria: age \> or = 50 yrs. patients with acute coronary syndromes or stable coronary artery disease. exclusion criteria: insulin dependent diabetes inability or unwillingness to undergo computed tomography scanning severe renal failure (serum creatinine \>250 µmol/l or estimated glomerular filtration rate \<30 ml/min) known contrast allergy inability to give informed consent. females in child bearing age will undergo pregnancy test if pregnancy suspected. participation in other research studies requiring exposure to further radiation (over and above mentioned in this study).

Keywords: culprit plaques vulnerable plaques pet calcification inflammation
feasibility and acceptability study of the "o'dide" application in people suffering from an addiction

Conditions: Substance-Related Disorders; Personality Disorders

Summary: substance use disorders (sud) are associated with cognitive schemas that lead to care attrition and mistrust towards care. considering this within sud management, it is important to establish a confident relation between the patient and the care team to favorize acre observance. however, it demands an important availability of the healthcare team, allowing for frequent interactions at all times, including at night and during days off. with the present study, the investigator postulated that an application called ô dide for digital interaction for detoxification engagement, that aims to help the caregivers maintaining a link with the patient in order to facilitate confidence in the relationship, could favorize care observance especially consumption report.

the present research aims to assess the feasibility of the "ô dide" application after 8 weeks of use by patients treated for a disorder related to substance use at the toulouse university hospital.

Eligibility criteria:
inclusion criteria: * suffering from any type of addiction, with an active addiction requiring weekly monitoring of consumption * possessing an android smartphone or having access to an android smartphone and having access to an internet connection * able to read and understand french * affiliated or beneficiary of a social security scheme. * free, informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research). exclusion criteria: * patient with cognitive or psychiatric disorders that may affect their ability to consent * participation in another protocol involving a modification of the treatment for addiction * person under legal protection, guardianship or curatorship * known or suspected pregnancy

Keywords: e health application substance use disorders personality disorders care observance
studying urine and blood samples in women with newly diagnosed breast cancer

Conditions: Breast Cancer

Summary: rationale: studying samples of urine and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. purpose: this study is looking at urine and blood samples in women with newly diagnosed breast cancer.

objectives: * to determine the association between the genotype for 4 metabolic enzymes (e.g., cyp1a1, gstm, gstt, and gstp) in women with newly diagnosed breast cancer that play key roles in the metabolism of environmental human carcinogens and the risk of breast cancer development. outline: urine and blood samples are collected for dna, mutation, and polymorphism analysis. the biological samples may be stored and used for future research. patients complete a baseline questionnaire to collect basic risk/exposure information, including demographic factors (e.g., age, weight, height, and body mass index), menstrual/reproductive history, medical history, medication use, smoking history, alcohol consumption, exposure to chest x-ray, and family history of breast cancer in first-degree relatives. patients also complete a second hand smoke questionnaire to collect information on cigarette smoking history and second hand smoke exposure and a food frequency questionnaire to collect information on the frequency of use of specific fruits and vegetables (e.g., cruciferous vegetables) and to estimate usual dietary intake of 33 nutrients during the past year (e.g., total fat, saturated fat, oleic fat, linoleic fat, carbohydrates, protein, vitamins \[e.g., a, b1, b2, niacin, b6, folate, c, and e\], minerals \[e.g., calcium, magnesium, iron, and zinc\], electrolytes \[e.g., sodium and potassium\], and dietary fiber). patients' medical charts are also reviewed to collect information on age, gender, ethnic background, medical history, and medical care.

Eligibility criteria:
inclusion criteria: * newly diagnosed breast cancer * planning to undergo a diagnostic biopsy or surgery * must have tumor tissue available * hormone receptor status not specified * more than 6 months since prior chemotherapy or radiotherapy * pre- or post-menopausal exclusion criteria: -psychiatric history that would preclude giving informed consent

Keywords: breast cancer
tumor metabolism of lung cancer in patients who underwent percutaneous radiation measured with f-18-fdg-pet

Conditions: Lung Cancer

Summary: the purpose of the study is to describe the regional and global fdg-kinetics in non-small-cell lung cancer (nsclc) during percutaneous radiation therapy.


Eligibility criteria:
inclusion criteria: * histologically confirmed nsclc not curable by surgery * karnofsky \> 80% * tumor volume and localization allow curative radiotherapy * written consent exclusion criteria: * metastases * diabetes * pregnancy * psychiatric impairment

Keywords: radiation therapy f-18-fdg nsclc
study of bn83495 in post-menopausal women with endometrial cancer post-chemotherapy

Conditions: Endometrial Cancer

Summary: the purpose of the protocol is to determine the effect of bn83495 on the progression of endometrial cancer with estrogen receptor in post menopausal women who had previously received chemotherapy.


Eligibility criteria:
inclusion criteria: * provision of written informed consent prior to any study related procedures. * postmenopausal or ovariectomised female patient over 18 years of age. * histologically confirmed diagnosis of er positive endometrial carcinoma in the primary tumour or metastatic disease * patient has received one line of chemotherapy prior to enrolment in the adjuvant or in the metastatic setting (including chemoradiotherapy) and progressed after this line of chemotherapy * patient has at least one measurable disease site (recist criteria version 1.1) exclusion criteria: * patient has received hormone therapy for endometrial cancer in the adjuvant or metastatic setting * patient has received more than one line of chemotherapy in the adjuvant or metastatic setting * patient was treated with any other investigational agent within the 3 weeks before study entry. * patient has ongoing cardiac dysrhythmias grade ≥2, atrial fibrillation of any grade (nci ctcae) or qtcf interval \>460 msec.
optimize the effects of repetitive transcranial magnetic stimulation on neuropathic pain

Conditions: Neuropathic Pain; Repetitive Transcranial Magnetic Stimulation

Summary: neuropathic pain (np) is one type of refractory chronic pain condition,medical treatments for np is limited because of its poorly response.repetitive transcranial magnetic stimulation (rtms) can induce neuroplastic changes which has been used to manage chronic pain conditions. indeed, high-frequency (≥ 5 hz) rtms over the primary motor cortex (m1) is suggested to be able to reduce neuropathic pain in randomized controlled studies. overall, the clinical application of rtms in chronic pain is still limited by the response rate, whereby it is close to moderate and far from being excellent at its best. therefore this project designed a series of clinical trials to optimize the analgesic efficacy of rtms. according to the research results of investigators previous project, patients with neuropathic pain were divided into responders and non-responders after 5 consecutive days of 10hz rtms or pctbs intervention (see project id:2021-0751)according to the change of pain intensity, and then different trials will be applied to responders and non-responders to optimize the analgesic effect of rtms.

for non-responders (whose visuo-analogic scale (vas) decreased less than 20 mm or t1-t0/t0×100%\<30%), a feasible method is to switch stimulation targets. so the investigator will change the stimulation target from m1 to dorsolateral prefrontal cortex (dlpfc), and then delivered another 5 days consecutive interventions to assess the efficacy. for responders (whose vas decreased an average of 20 mm or more or t1-t0/t0×100%≥30%), the investigator further investigate the long-lasting effect of rtms. the patients will participate a continuous trials (2 sessions weekly for 2 weeks) and 4 weeks follow up.

Eligibility criteria:
inclusion criteria: * （1）woman or man over 18 years and under 85 years; （2）clinical diagnosis of neuropathic pain (3) pain for at least 3 months, at least moderate intensity (≥ 4/10 assessed by vas) ; (4) stable pharmacological treatment for pain at least 2 weeks before inclusion; (5) able to cooperate in completing questionnaire. exclusion criteria: * (1)any clinically significant or unstable ongoing medical or psychiatric disorder including major depression; (2) history of substance abuse (alcohol, drugs); (3) past treatment with repetitive transcranial magnetic stimulation (rtms); (4) contraindications to rtms (previous severe head trauma or neurosurgical intervention, past or current epilepsy, active brain tumor, intracranial hypertension, implanted ferromagnetic devices, e.g., cardiac pacemaker, neurostimulator, or cochlear implants); (5) other type of pain more severe than neuropathic pain; (6) any difficulty to fill out questionnaires (due to language or cognitive problems); (7) impossibility to be followed during the time course of the study;
a study of the safety and efficacy of vigam® liquid in patients with primary or secondary antibody deficiency

Conditions: Primary or Secondary Antibody Deficiency

Summary: to determine: 1. the safety of vigam® liquid in patients with primary or secondary antibody deficiency (pad or sad). 2. the efficacy of vigam® liquid in patients with primary or secondary antibody deficiency. 3. the half-life of vigam® liquid after 4 months of treatment. 4. the subclass and total gammaglobulin concentrations after each infusion of vigam® liquid.


Eligibility criteria:
inclusion criteria: * adults (18-80 years) with pad or sad * with a low serum igg (\<6 g/l) and a history of recurrent infections * requiring and eligible for polyvalent intravenous immunoglobulin (ivig) replacement therapy * non-reactive for hbsag and with an alanine aminotransferase (alt) level less than twice upper limit of normal prior to entry into the trial exclusion criteria: -
prevalance of sleep bruxism among a group of egyptian children

Conditions: Sleep Bruxism

Summary: the goal of this observational study is to detect the prevalence of sleep bruxism in a group of egyptian children and detect its relation to screen-time and sugar consumption. the main questions it aims to answer are: 1. in a group of egyptian children what is the prevalence of sleep bruxism? 2. what is the relation between sleep bruxism and screen time and sugar consumption?

parents of a group of egyptian children aged 6-8 years old will be asked to fill 1. an informed consent 2. children sleep habit questionnaire to detect the presence of sleep bruxism or not? 3. food frequency questionnaire of health behaviour sugar consumption questionnaire 4. leisure time, television use, computer use sections of the health behaviour sugar consumption questionnaire

Eligibility criteria:
inclusion criteria: * positive subject acceptance for participation in the study * healthy children aged 6-8 years old * both genders * the presence of mixed dentition with permnant first molar erupted exclusion criteria: * children with mental or neurological disorders * children with systemic disorders * children who use medications that could not interfere with the central nervous system * children suffering from sleep disorders. e.g: obstructive sleep apnea