Kornimate/medical-research-clean huggingface dataset:
location and anatomic characterization of the sacrospinous ligaments in women with pelvic organ prolapse

Conditions: Pelvic Organ Prolapse

Summary: pelvic organ prolapse is a common disorder that results in significant patient morbidity. approximately 1 in 9 women undergo surgery for the correction of pelvic organ prolapse (pop) and associated bladder and bowel dysfunction. despite its common occurrence, the cause of pop remains largely unknown. prolapse is thought to be caused by direct injury to the levator ani (la) muscle, denervation of the pelvic floor musculature, or fascial damage incurred during childbirth trauma. the sacrospinous ligaments are commonly employed surgical structures employed to repair vaginal prolapse. despite the frequent use of these structures in prolapse surgery, there is a paucity of information regarding the identification of these structures outside of surgical dissection. furthermore, there is no published data describing the relative distances between the apex of the vagina and these ligaments in women with prolapse. recent developments in imaging have enabled the identification of the distal subdivisions of the levator ani, classifying as: pubovaginalis, puboanalis, and the puboperinealis as the subdivisions of the pubovisceralis. the visualization of these structures is possible using a 3d ultrasound technique (bk medical, wilmington, ma), that has been validated in cadavers and in live humans, with excellent interrater reliability. the investigators propose to use this technology to explore the anatomy of the sacrospinous ligaments.


Eligibility criteria:
inclusion criteria: * age 21-80 years old * stage iii or higher pelvic prolapse exclusion criteria: -prior pelvic surgery
barley beta-glucan, glycemic control, and appetite

Conditions: Diet, Healthy; Blood Sugar; High; Diabetes; Appetite and General Nutritional Disorders; Appetitive Behavior

Summary: novel barley varieties high in the soluble fiber β-glucan have the capacity to improve population health through improving glycemic control. sweetened and unsweetened wholegrain barley foods were tested in a randomized, controlled, crossover human clinical trial to assess impact on postprandial appetite and food intake.


Eligibility criteria:
inclusion criteria: * 18-50 years of age * body mass index (bmi) values of 18.5-40.0 kg/m2 * normal fasting blood glucose (\<100 mg/dl) exclusion criteria: * use of medications known to be associated with weight change (e.g., beta-blockers) * use of steroid pills or shots such as prednisone or cortisone * use of nicotine * weight change of ten or more pounds in the last three months * major daily variation in physical activity (e.g., athletes in training) * history of extensive small bowel surgery or surgery to treat obesity * history of heart attack, stroke, or bypass * history of cancer within the last five years (exception: non-melanoma skin cancer) * recent or current medical diagnosis or medical treatment that would alter appetite, energy needs, satiety, and/or could impact the results of the trial * medical diagnoses of diabetes, cardiovascular disease, high levels of blood lipids, asthma, cold, and flu (exception: hypertension, if treated with medication prescribed more than three months prior to the screening activity) * fear of blood or needles * dietary restrictions that would interfere with consuming test foods (e.g., gluten intolerance, vegan, corn syrup allergy) * following a weight modification diet * sensitive to food textures present in the test foods * following personal schedules that would not permit attendance at all scheduled testing sessions * unable to comprehend the nature of the trial or instructions * unable to understand english sufficiently to complete the trial

Keywords: beta-glucan fiber glycemic control appetite
knee joint angle affect muscle architecture in children with cerebral palsy

Conditions: Spastic Cerebral Palsy

Summary: to determine if there is an effect of knee joint angle on muscle architecture in children with spastic cerebral palsy

to determine if there is an effect of knee joint angle on muscle architecture in children with spastic cerebral palsy

Eligibility criteria:
inclusion criteria: * a diagnosis of spastic diplegia cp. * age from 3 to 6 years. * spasticity grade 1 and 1+ according to the modified ashworth scale. * level iii motor function according to the growth motor function classification system. * hamstring muscle tightness. * able to understand and follow instructions. exclusion criteria: * epilepsy. * significant visual or auditory problems according to medical reports (audio-vestibular and ophthalmic examination). * structural or fixed soft tissue deformities of the lower extremities. * neurological or orthopedic surgery in the past 12 months. * botox injection in the lower extremities in the past 6 months.

Keywords: muscle architecture knee joint angle cerebral palsy spasticity children
endovascular limb salvage in trinidad and tobago

Conditions: Limb Salvage Rates With Endovascular Therapy

Summary: the purpose of this study was to investigate limb salvage rates in patients with critical limb ischemia after endovascular revascularization.

a retrospective analytical study assessing limb salvage attempts and outcomes in 157 consecutive patients with cli and tissue loss. it was for the period of may 2018 and may 2021 at eric williams medical sciences complex. the objectives of this study include primary: to determine the success rate of target lesion revascularisation using endovascular limb salvage techniques in critical limb ischemia patients with minor and major tissue loss. secondary objectives included: 1. to compare and contrast limb salvage rate to international standards 2. to assess the maintenance of amputation-free survival and bipedal ambulation 3. to evaluate the angiosome concept and its effect on wound healing 4. to evaluate primary patency rate 5. to assess the overall morbidity and mortality of endovascular treatment for critical limb ischemia 6. to observe the outcomes of various wound healing techniques and its efficacy

Eligibility criteria:
inclusion criteria: cli patient with tissue loss who underwent infra inguinal endovascular limb salvage exclusion criteria: cli patients with tissue loss who had surgical bypass cli patients with no tissue loss

Keywords: critical limb-threatening ischemia (clti); endovascular revascularization (evr); peripheral arterial disease (pad); peripheral vascular disease (pvd).
endoscopic suturing system for tissue apposition

Conditions: Obesity

Summary: the objective of this feasibility trial is to evaluate the ethicon endo-surgery endoscopic suturing system (ess) for tissue apposition and reduction of the size of a dilated gj anastomosis in subjects who are regaining weight after successful weight loss following gastric bypass. post-procedure weight will be followed to assess whether weight loss is resumed. the ess is an fda-cleared (510(k)) sterile, single-use, disposable suturing system indicated for endoscopic placement of suture(s) and approximation of soft tissues. it is designed to facilitate endoscopic gastrointestinal procedures.


Eligibility criteria:
inclusion criteria subjects must fulfill the following criteria to be entered in this study: * review and sign informed consent; * between 21 and 65 years of age (inclusive) at time of trial enrollment; * documented roux-en-y gastric bypass (rygb) surgery date * documented baseline weight at the time of rygb procedure; * \> 12 months post rygb); * body mass index (bmi) \> 30 and at least 20 pounds in excess of post-rygb weight nadir; * patients initially achieved at least 50% excess weight loss (ewl) post rygb; * visible anastomotic junction (between gastric pouch and the roux-limb); * stoma size at screening \> 15mm; and * negative serum pregnancy test for women of childbearing potential. exclusion criteria subjects will be excluded from the trial for any of the following: * documented history of esophageal pathology (e.g., esophageal varices, barrett's esophagus); * american anesthesia association (asa) class iv or v and/or any contraindications to monitored anesthesia; * documented history of gj anastomosis stricture (within 6 months); * documented history of previous rygb revision; * presence or documented presence of gastric/duodenal ulcers; * presence of sepsis; * medical or physical endoscopic contraindications, including esophageal varices or bleeding, laryngeal perforation, trauma to pharynx, aspiration pneumonia, acute peritonitis, and other conditions where general endoscopic techniques and/or placement of overtube are contraindicated; * chronic non-steroidal anti-inflammatory drug (nsaid) use (subjects taking a single aspirin tablet per day for cardioprotection are considered acceptable); * uncontrolled diabetes; * physical or psychological condition which would impair trial participation per investigator discretion; * binge-eating or similar eating disorders; * unable or unwilling to attend follow-up visits and examinations; * concurrent surgical procedure (intra-operative exclusion during ess procedure); * participation in any other investigational device or drug trial within 30 days prior to enrollment; or * any condition, which precludes compliance with the trial.

Keywords: gastrojejunostomy stoma
sbrt with atezo/bev for hcc

Conditions: Hepatocellular Carcinoma

Summary: a phase i dose escalation and pharmacodynamic study of repeated dose stereotactic body radiotherapy (sbrt) administered with concurrent atezolizumab and bevacizumab for patients with advanced hepatocellular carcinoma (hcc)


Eligibility criteria:
inclusion criteria: * subjects must have hepatocellular carcinoma (hcc) that is not amenable to curative-intent surgical or ablation (where surgery or ablation are not indicated due to disease extent, co-morbidities, or other technical reasons) and systemic therapy is indicated. exclusion criteria: -
skin conduction device for measuring hot flashes in postmenopausal women with hot flashes

Conditions: Hot Flashes

Summary: rationale: measuring how often hot flashes occur in postmenopausal women may be done by using a skin conduction device or by using a diary. purpose: this clinical trial is comparing a skin conduction device with a hot flash diary as a way of measuring hot flashes in postmenopausal women with hot flashes.

objectives: * correlate hot flash frequency, as measured by an ambulatory sternal skin conductance measuring and recording tool, with patient-recorded hot flash frequency using a hot flash diary in postmenopausal women with hot flashes. * determine the comfort, obtrusiveness, and feasibility of using the skin conductance recording tool for measuring hot flashes when worn daily for five weeks in these patients. outline: patients wear an ambulatory sternal skin conductance hot flash device continuously for 5 weeks. patients complete hot flash diaries once daily for 5 weeks. patients also complete the comfort, bother, and weight questionnaire at the end of week 5. projected accrual: a total of 25 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * diagnosis of bothersome hot flashes, defined by their occurrence of ≥ 4 times/day * daily hot flashes have been present for ≥ 1 month patient characteristics: * female * postmenopausal * ecog performance status 0-1 * no history of allergic or other adverse reactions to adhesives * no other medical condition known to cause sweating and/or flushing * willing to record hot flashes in a hot flash diary daily for 5 weeks * willing to wear a skin conductance device 24 hours a day for 5 weeks * no implanted pacemakers or metal implants * no reliance on other electronic devices for regular monitoring (i.e., insulin pumps or blood pressure monitors) prior concurrent therapy: * not specified

Keywords: hot flashes
fentanyl test in children's adenotonsillectomy

Conditions: Obstructive Sleep Apnea

Summary: the purpose of this study is to discuss the relationship between the result of fentanyl test and required dosage of morphine for children with osas after adenotonsillectomy；and to evaluate the ability of predicting requested dosage of morphine postoperatively.

all the patients were intubated. sevoflurane was used for maintenance without any opioids. before the end of the procedure, spontaneous respiratory was recovered. all the patients were given 1 mcg/kg fentanyl i.v. after the end of the procedure. the positive result was defined as spontaneous respiratory rate decreased more than 50%, the others were defined as negative result. all the patients were given morphine for pain relief according to our protocol after extubation.

Eligibility criteria:
inclusion criteria:meet all of the following 1. the american society of anesthesiologists (asa) class ⅰ \~ ⅱ 2. the age of 3 \~ 7 years old 3. children who underwent selective adenotonsillectomy. exclusion criteria:meet anyone of the following 1. craniofacial malformations 2. mental retardation 3. bmi \> 22 kg/m2 4. a history of bronchial asthma 5. a recent history of opioid use.

Keywords: adenotonsillectomy fentanyl
idarubicin plus cytarabine (ia) vs ia plus cladribine (iac) as induction regimen to treat initially diagnosed acute myeloid leukemia (aml)

Conditions: Acute Myeloid Leukemia

Summary: the goal of this clinical trial is to compare the clinical efficacy and safety of iac regimen and ia regimen as induction chemotherapy for initial diagnosed acute myeloid leukemia (aml) patients. the main question it aims to answer is: •does iac regimen higher the complete remission rate in initial diagnosed aml patients? researchers will compare iac regimen to ia regimen to see if iac works to treat aml. participants will: * receive iac or ia as induction regimen * receive a second cycle of re-induction if partial remission * visit the clinic once every 3 to 6 months for assessment


Eligibility criteria:
inclusion criteria: * initially diagnosed as aml (except apl) * aged between 18 and 60 year old * eastern cooperative oncology group (ecog) score no more than 3 * informed consent file (icf) signed exclusion criteria: * aml secondary to chronic leukemia and myeloproliferative neoplasms (mpns) * with other underlying malignancies * severe and uncontrolled infection * intolerant to the chemotherapy

Keywords: acute myeloid leukemia
topical 0.05% clobetasol propionate in vaseline versus uva-1 phototherapy in vulvar lichen sclerosus

Conditions: Vulvar Lichen Sclerosus

Summary: lichen sclerosus is a rare, chronic cutaneous disorder with a predilection for the genital area. any age group may be affected, although it is seen more often in postmenopausal women. the current gold standard treatment is topical ultrapotent corticosteroids such as clobetasol. here we compare uva1 phototherapy with 0,05% clobetasol propionate in vaseline for the treatment of vulvar lichen sclerosus.

genital lichen sclerosus is a rare chronic inflammatory connective tissue disease. the association with other autoimmune diseases and the detection of autoantibodies against ecm-1 point to an autoimmune genesis. genital lichen sclerosus typically affects women around and after the menopause. common sites of affection are the vulva (clitoris and labia majora) and the anus in women, the prepuce and the glans penis in men. skin lesions include ivory-white, atrophic, porcelain-like plaques with a tendency to atrophy and fissures in the advanced stages. first-line therapy for genital lichen sclerosus in the active, inflammatory phase is the use of topical glucocorticoids. alternatively, topically applied hormone-containing emollients and topical calcineurin inhibitors are widely used. however, the use of topical corticosteroids is because of the associated long-term side effects (atrophy, striae) limited. in the treatment of localized scleroderma (morphea), a similar sclerosing disease, the use of ultraviolet radiation (uva1) has proved highly effective. after a pilot study, the high-dose uva1 phototherapy (120 j / cm ²) was significantly more effective was a low-dose uva1 (20 j / cm ²), however no difference could be found in subsequent studies. meanwhile, the medium-dose uva1 phototherapy in circumscribed scleroderma has been determined as the most effective therapy regime and is included in the german dermatological guidelines (see also awmf guideline for diagnosis and therapy of circumscribed scleroderma at: http://www.uni-duesseldorf.de/awmf/ll/013- 066.htm).

Eligibility criteria:
inclusion criteria: * patients with genital lichen sclerosus * age \> 18 years * willingness to participate in this study * no topical steroids within the last 4 weeks exclusion criteria: * age \< 18 years * known photodermatosis (eg, solar urticaria, polymorphous light eruption) * known genodermatosis with uv-sensitivity * treatment with photosensitizing drugs * history of skin cancer * significant uv exposure 3 months before study entry * application of uv radiation therapies outside of the study conducted by uv irradiation: as: puva, uva (including uva1), uvb (including sea) in the last 4 weeks before study entry or during the study period

Keywords: lichen sclerosus genital vulvar uva1
"medikidz explain jia comic book- hebrew"

Conditions: Juvenile Idiopathic Arthritis

Summary: we believe, that the results of this study will show that children learn from the comic book about their disease, and are now more aware and less frightened about it, and increase their compliance.

we believe, that the results of this study will show that children learn from the comic book about their disease, and are now more aware and less frightened about it, and increase their compliance. if so, it may promote the use of comic books or other fun educational tool in teaching children various other diseases.

Eligibility criteria:
inclusion criteria: children with jia aged 10-18 after parents signed icf exclusion criteria: parents that do not wanf their children to participate in the study.
procalcitonin in diagnosing bacteremia in the emergency department

Conditions: Sepsis; Fever

Summary: nowadays, a physician plays a more important role in managing patients with potential infectious complications in the emergency room. previous studies demonstrated the importance of early and adequate anti-microbial therapy in reducing the mortality and morbidity of patients with severe sepsis. however, in one study, about 6% of clinically significant bacteremic patients were misdiagnosed and discharged from the emergency room. in other studies, about 8.5 to approximately 17% of empirical antibiotic selection was judged inappropriately according to subsequent microbiology, and anti-microbial susceptibility was a result. it reflects the diversity in the presentations of infectious diseases and limited available microbiological reports from the first-line emergency physicians. timely diagnosis and selection of appropriate antibiotics/treatment in treating those patients challenge an emergency physician more than ever before. a serum marker, procalcitonin, was recently demonstrated to be a potential indicator in distinguishing between non-infectious and infectious acute inflammatory reactions, viral and bacterial infections, and non-bacteremic and bacteremic infections. it also demonstrates the association with high-mortality risk in patients with severe sepsis. however, some areas remain inconclusive in the clinical application of this potential serum marker. the investigators designed this prospective study with the following purposes: 1. to clarify the sensitivity and specificity of the serum procalcitonin quantitative test as a clinical indicator of sepsis; 2. to identify the cut-off value of the serum procalcitonin level in sepsis screening among various groups of patients with different co-morbidities; 3. to test the potential role of the procalcitonin quantitative test in identifying occult sepsis in patients with an acute undifferentiated febrile reaction in the emergency room; 4. to test the possibility of the sequential procalcitonin quantitative test as a serological guide of the appropriateness of an empirical antibiotic before the microbiology results are available. conclusions in the investigators' study will clarify the clinical application of the serum procalcitonin quantitative test in the differential diagnosis of patients with systemic inflammatory reaction syndrome, the screening of high-risk sepsis patients, and the effectiveness of an empirical antibiotic evaluation.


Eligibility criteria:
inclusion criteria: * emergency department patient * patient suspected sepsis exclusion criteria: * patient less than 15 years of age

Keywords: emergency department blood culture antimicrobial therapy
programs to support you during chemotherapy

Conditions: Depression; Fatigue; Stage IIA Colorectal Cancer; Stage IIB Colorectal Cancer; Stage IIC Colorectal Cancer; Stage IIIA Colorectal Cancer; Stage IIIB Colorectal Cancer; Stage IIIC Colorectal Cancer; Stage IVA Colorectal Cancer; Stage IVB Colorectal Cancer; Pancreatic Cancer; Esophageal Cancer; Appendix Cancer; Stomach Cancer; Gallbladder Cancer; Liver Cancer; Small Intestine Cancer; Large Intestine Cancer; Anal Cancer; Biliary Tract Cancer; Gastrointestinal Stromal Cancer

Summary: this randomized pilot trial studies how well two supportive programs work for improving fatigue and depressive symptoms in patients with gi undergoing chemotherapy. possible mediators such as psychological stress, circadian disruption, and inflammation, will also be explored.

primary objectives: i. to conduct a pilot randomized controlled trial of the yoga skills training (yst) versus a caring attention control (ac) group among adults with colorectal cancer (crc) receiving chemotherapy to determine preliminary efficacy for the primary outcome of fatigue, secondary outcome of depressive symptoms, and possible mediators (i.e., psychological stress, circadian disruption, inflammation) as assessed by standard measures. secondary objectives: i. to measure the impact of the yst versus the ac on daily assessments of fatigue, depressive symptoms, and proposed mediators in the same trial and explore relationships among daily and standard assessments. ii. to qualitatively assess perceived efficacy of the yst and ac and acceptability of new methodology through semi-structured interviews in a subset of 20-40 participants. outline: patients are randomized to 1 of 2 groups. group i (yst): patients participate in yst consisting of four 30 minute in-person yoga sessions at weeks 2, 4, 6, and 8 that instructs skills to enhance mindfulness and promote relaxation, through instruction of awareness, movement, breathing practices, and meditation. group ii (ac): patients participate in four 30 minute in-person sessions of supportive conversation at weeks 2, 4, 6, and 8. after completion of study, patients are followed up at 4 weeks.

Eligibility criteria:
inclusion criteria: * scheduled to receive first-line fluorouracil (5fu)-based intravenous chemotherapy treatment for a gastrointestinal cancer (stages ii-iv) * have an eastern cooperative oncology group performance status of =\< 1 * ability to understand and the willingness to sign and informed consent document in english exclusion criteria: * has a self-reported history of diagnosed uncontrolled obstructive sleep apnea (ok if using cpap), sleep-related seizures, sleep walking more than one time per week, restless leg syndrome, or a job with night shifts