Kornimate/medical-research-clean huggingface dataset:
research about impact of hpv integration on the prognosis of women with persistent hr-hpv infection

Conditions: HPV Infection; LSIL, Low-Grade Squamous Intraepithelial Lesions; HSIL, High-Grade Squamous Intraepithelial Lesions; Virus Integration

Summary: clinically, patients with persistent hr-hpv infection for more than 18 months or hr-hpv infection with cin2 + need regular colposcopic biopsy to assess the outcome and progression of the disease. a total of 1000 participants with persistent hr-hpv infection (100 cases/center) were recruited from multiple centers, and hpv integration status and vaginal flora diversity were sequenced at baseline, 6th month, 12th month and 24th month, respectively, through prospective cohort studies. and to evaluate the influence of hpv integration status and flora changes on the prognosis of women with persistent hr-hpv infection.

this study aims to: 1) determine the association between hpv integration and natural outcome in women with persistent hr-hpv infection. 2) determine the prognostic value of different hpv integration status in women with persistent hr-hpv infection. 3) determine the relationship between the integration status of different hpv genes in the cervix and the diversity of vaginal flora in women with persistent hr-hpv infection, and its prognostic value in women with lsil and hsil.

Eligibility criteria:
inclusion criteria: * non pregnant people with sexual history； * persistent infection of the same type of hr-hpv for more than 18 months or hr-hpv infection with cin2 +; * no history of previous surgery at the cervical site. * asexual life, no vaginal medication or flushing before 72 hours of sampling. exclusion criteria: * within 8 weeks after pregnancy or postpartum. * patients with history of genital tract tumor. * history of hpv vaccination. * previous history of hysterectomy, cervical surgery, pelvic radiotherapy historical. * in recent one month, she has received genital tract infection, hpv or other stds treatment related to the infection of mycoplasma. * use antibiotics or vaginal microecological improvement products in recent 1 month.
reliability and validation of new manual dynamometer to measure lower limb strength

Conditions: Muscle Strength; Muscle Weakness

Summary: introduction: there are several ways to assess muscle strength: not only subjective ways, but also high standard equipment, such as isokinetic dynamometers. these, however, are expensive, and require extensive training. over the years, manual dynamometers were produced, portable equipment that simplify its use. among them, a national equipment was developed, but its reliability and validation are yet to be confirmed, compared to equipment already used, such as the lafayette®. objective: assess the reliability of a new manual dynamometer - medeor® device (sp tech model) -, in relation to the gold standard, lafayette® device (model 01165), already validated, in the evaluation of muscle strength of the knee and hip groups. methods: a total of 26 recruits of both sexes were selected. muscle strength was measured by lafayette® and medeor® dynamometers in the following groups: knee flexors and extensors; flexors, extensors, abductors, adductors, hips internal and external rotators. each data was collected 3 times, and then the average was calculated.

keywords: muscle strength; muscle strength dynamometer; lower extremity.

Eligibility criteria:
inclusion criteria: * 20-40 year * both sex * healthy exclusion criteria: * individual who practiced physical activity, * cognitive disability * osteomioarticular diseases in lower limb and/or spine * rheumatic or cardiorespiratory disease
evaluation of outcomes of coronary artery bypass grafting.

Conditions: Ischemic Heart Disease; Coronary Artery Bypass Grafting

Summary: evaluation of outcomes of coronary artery bypass grafting.

evaluation of outcomes of coronary artery bypass grafting (cabg) on-, off- pump, pump assisted as well as bimammary coronary artery bypass grafting. objective: to assess myocardial ischemic-reperfusion damage during different kinds of cabg. to assess complications after during different kinds of cabg.

Eligibility criteria:
inclusion criteria: * ischemic heart disease with indications for coronary artery bypass grafting. exclusion criteria: * valve disease

Keywords: ischemic heart disease coronary artery bypass grafting on-pump cabg off-pump cabg pump - assisted cabg myeloperoxidase after cabg
creating a diagnostic decision rule for shoulder injury: cash-trial

Conditions: Trauma

Summary: what combination of ≤ 6 clinical variables will give the highest specificity for indicating significant shoulder injuries (fractures or dislocations) with a set sensitivity of ≥ 97%? although shoulder trauma is a common injury, there is no clinical decision rule to determine the necessity for radiography for these traumas. with this trial the investigators aim to develop such a rule to reduce the amount of radiographs without missing any significant injuries. the primary objective is to compose a set of clinical diagnostic criteria predictive of shoulder fractures or dislocations that would reduce the amount of radiographs without missing any significant injuries. a second objective is to determine if the clinical decision rule is applicable for triage use.

the cash (clavicle-ac-joint-sub-capital-humerus) trial is designed as a cross sectional interobserver study. it will randomize between first examiner of the patient to determine applicability for triage use and use a list of 19 criteria to determine a clinical decision rule for significant shoulder injuries. method/intervention after admittance to the ed, all consecutive shoulder injury patients will be assessed for eligibility in the study. after informed consent is given, the patient will be randomized for first observer (ed physician or triage nurse) to be examined, which means they will be assessed in duplo. the patient will be examined by means of a score form, which contains 19 different diagnostic criteria. the criteria are grouped: anamnesis, inspection, palpation and pain/range of motion(rom). after completing the list, patients will get a full set of shoulder x-rays: shoulder ap- and axial-view, and clavicle ap and 30' cranio-caudal view. the trial participation for the patient will be completed at this point and final diagnosis and treatment are provided by the ed physician according to his/her own findings and interpretation of the radiographs. for the study, the radiographs will be reassessed by one consultant radiologist specialized in skeletal trauma.

Eligibility criteria:
inclusion criteria: * aged18-65 years * trauma \<48h exclusion criteria: * any prior ipsilateral shoulder surgery. * any diseases of the bones potentially influencing fracturability (osteogenesis imperfecta, osteoporosis, achondroplasia, m. kahler, chronic (\> 1yr) prednisone use \> 5mg) * any shoulder injury as part of a multi-trauma or high energy trauma (het) with distractible injuries * any condition that will influence the perception of pain (e.g. alcohol intoxication, psychiatric problems, mental retardation)

Keywords: trauma of the shoulder
feasibility of a modified positive airway pressure device to treat sleep disordered breathing

Conditions: Sleep Apnea, Obstructive; Obesity Hypoventilation Syndrome

Summary: this study will use a modified version of a positive airway pressure device to supply air to the participant, while undergoing supervised polysomnography. positive airway pressures are typically applied to many patients with hypoventilation, in this study these pressures will be titrated by a qualified sleep technician. during the night these pressures will be altered to optimise comfort.


Eligibility criteria:
inclusion criteria: * aged 18+ * patients diagnosed with obesity hypoventilation syndrome (ohs) and/or obstructive sleep apnea (osa) by a practicing sleep or respiratory physician, requiring positive airway pressure (pap) therapy exclusion criteria: * recent cardiac or respiratory arrest * gastro intestinal bleeding, ileus or recent gastrointestinal surgery * coma, decreased level of consciousness or agitation * anatomical or subjective difficulty with airway access e.g. facial surgery, trauma, vomiting upper airway obstruction * cerebrospinal fluid leak, abnormalities of the cribiform plate or prior history of head trauma.
from known to new genes in dyslipidemia

Conditions: Dyslipidemias

Summary: the mechanism of the majority of the dyslipidemia is multifactorial at the molecular level and remains elusive in more than 50% of the patients in many clinical conditions. next generation sequencing, a booming strategy, improves the molecular diagnosis efficiency in both monogenic and polygenic dyslipidemia. in order to decipher the mechanisms involved in the occurrence of dyslipidemia, in addition to the exploration of known candidate genes and single nucleotide polymorphisms (snp) involved in polygenic modulation, new genes involved in the regulation of lipoprotein metabolism or associated with lipids concentrations need to be sequenced in large groups of dyslipidemic patients. the goal of this project is to gain new insight into genotype/phenotype correlation.


Eligibility criteria:
inclusion criteria: * patients with a family documented history of primary hypercholesterolemia, hypertriglyceridemia, hypobetalipoproteinemia, combined hypolipidemia and combined hyperlipidemia according to the european atherosclerosis society and/or published data. * patients with major secondary dyslipidemia. exclusion criteria: * inability to provide written informed consent * lack of legal representative
attention bias modification for the improvement of anxiety in adolescent and young adult cancer survivors

Conditions: Childhood Hematopoietic and Lymphatic System Neoplasm; Childhood Malignant Solid Neoplasm

Summary: this clinical trial studies how well attention bias modification (abm) improves anxiety in adolescent and young adult (aya) cancer survivors. cancer-related anxiety is the most prevalent mental health problem affecting aya cancer survivors. cancer-related anxiety is associated with long-term negative outcomes such as poor quality of life, depression, distress, substance use, sleep problems, fatigue, and pain. abm uses techniques to help patients change the way they react to environmental triggers that may cause a negative reaction. abm uses brief self-guided smartphone applications. patients complete repetitive association reaction-time tasks targeting automatic and unconscious negative attention biases to retrain attention away from perceived threat and towards a neutral or positive stimuli. gratitude-finding and savoring activities are also provided to maintain and increase positive emotions. using abm plus gratitude-finding and savoring activities may improve anxiety in aya cancer survivors.

outline: patients are randomized to 1 of 2 arms. arm i: patients engage in abm over 10 minutes twice a week (biw) and respond daily to text messaging prompts activity for 4 weeks. arm ii: patients engage in inert attention task sessions over 10 minutes biw for 4 weeks. patients also receive and respond to text messaging prompts qd for 4 weeks. after completion of study intervention, patients are followed up at 4 weeks. after completion of this 4 week follow up survey, patients are given access to all components of abm and texts on study.

Eligibility criteria:
inclusion criteria: * age 15-29 years * diagnosis of cancer malignancy * received active/curative cancer treatment at seattle children's hospital (sch), or other study referring site (e.g. st. jude) * currently off active/curative cancer treatment * patient able to understand/read/write english language * cognitively able to participate in abm intervention and complete surveys * patient has access to smartphone able to send and receive text messages * patient has access to computer or smartphone for inquisit program exclusion criteria: * patients on active/curative cancer treatment * cognitively or physically unable to participate in abm intervention and surveys * patients who cannot understand/read/write english will be excluded from the research because the abm intervention is currently only available in english * furthermore, patients who do not have access to technology (smartphone/computer) will be excluded from the study as this technology is absolutely required to engage in the study intervention
combined effects of breathing teach back training and percussion in patients with pneumonia

Conditions: Pneumonia

Summary: pneumonia, marked by lung inflammation, leads to symptoms like fever and difficulty breathing, affecting millions globally. it particularly impacts children and the elderly. lung function is altered, reducing capacities and obstructing airflow. post-recovery, patients may experience dyspnea due to lingering fluids-deep breathing exercises, using teach-back training, aid rehabilitation. combining teach-back with chest percussion in physiotherapy aims to enhance respiratory outcomes in pneumonia patients. this will be a randomized clinical trial sample size calculated by epitool sample size calculator which is 30 patients 15 in each group. regular chest percussion involves a clapping technique in five drainage positions, with assisted suction. teach-back breathing exercises will also be implemented in this group in group a, individuals will perform teach-back breathing exercises with chest percussion. in group b, a similar protocol will be followed without the teach-back breathing exercises. data analysis, using spss version 21, will include the shapiro-wilk test for normality assessment. descriptive statistics, paired sample t-tests, wilcoxon signed-rank tests, independent sample t-tests, and mann-whitney u tests will be employed to analyze group measurements, changes over time, and differences between groups. this comprehensive approach aims to provide a thorough understanding of the study variables and measurements.


Eligibility criteria:
inclusion criteria: * both genders * age 35-45 years * diagnosed pneumonia exclusion criteria: * history of neurological disorders * history of fractures * history of other pulmonary complications (15) * patients having any chest infection will be excluded

Keywords: pneumonia percussion modified borg scale
ultrasound for scoliosis diagnostic evaluation

Conditions: Scoliosis Idiopathic; Scoliosis; Juvenile

Summary: scoliosis is a complex 3-dimensional deformity of the spine. it may occur at any time throughout growth and development and is typically detected through x-ray imaging. although effective at visualizing a curve, x-ray imaging is costly and may expose children to potentially harmful ionizing radiation. this is a 30 patient study to evaluate the reliability of ultrasound, an imaging technique without radiation, to effectively measure scoliosis deformities compared to the gold-standard of x-ray.

all patients who present to children's national medical center for initial evaluation of idiopathic or juvenile scoliosis will be approached.

Eligibility criteria:
inclusion criteria: * all patients ages 7-17 years who present to dr. matthew oetgen in the department of orthopaedic surgery \& sports medicine for clinical evaluation of scoliosis, * scoliosis curve type to include adolescent idiopathic (ais) or juvenile, and * have x-rays taken as part of clinical evaluation exclusion criteria: * not willing or able to provide consent, or * had x-rays taken at an outside facility, or * any underlying neuromuscular condition or syndrome and congenital deformities
the effects of resveratrol supplementation on inflammation and cognitive performance in healthy adults

Conditions: Cognitive Change; Mood; Systemic Inflammation

Summary: previous research has suggested that high levels of systemic inflammation can contribute to cognitive deficits and additional health problems; consumption of polyphenols have been shown to have an anti-inflammatory effect. resveratrol, a polyphenol found primarily in red grape skins, has previously been shown to improve brain blood flow and possibly brain function and may potentially reduce systemic inflammation, however there is limited research into this. this study will investigate the effects of 4 weeks daily consumption of resveratrol on inflammation and cognitive function in healthy adults.

each participant will be required to attend the laboratory on three occasions. the first of these will be an initial screening/training visit, this will take place in the afternoon and last 2 1/2 hours in total. during the initial visit participants will be asked to provide written informed consent. they will provide lifestyle and demographic data and screened regards to physical health (height, weight, blood pressure, waist to hip ratio). they will then complete a food frequency questionnaire and be trained on the computerised cognitive and mood tasks. participants will also be trained on completing the cognitive assessment battery on their mobile phone, they will complete a further 5 assessments on their phone, once the day before their first visit and every 7 days during the supplementation period. study days 1 and 2 (4 weeks apart) : participants will arrive at the laboratory at an agreed time in the morning (7am, 8.30am or 10am) having fasted for 12 hours, avoided caffeinated products for 18 hours, alcohol and over the counter medication for 24 hours and oral antihistamines for 48 hours prior to the session commencing. participants will provide a blood sample, they will then complete a short computerised cognitive assessment (\~20 minutes in length), followed by measurements of blood pressure and heart rate. following this the participants will consume their treatment for the day, followed by a 40 minute absorption period and then will complete the second cognitive assessment. participants will then provide a second blood sample. at the end of the first study session participants will be provided with their treatment and treatment diary, they will be instructed to take one tablet twice a day (30 minutes after breakfast and dinner). both study visits will be identical and will take place 29 days (+/- 2 days) apart.

Eligibility criteria:
inclusion criteria: * participants must self-assess themselves as being in good health. * aged 18 to 55 at the time of giving consent exclusion criteria: * have a body mass index (bmi) outside the range of 18.5-42kg/m2

Keywords: resveratrol polyphenol cognition mood inflammation
antiretrovirals and rate of progression in carotid artery intima-medial thickness in hiv

Conditions: HIV Infections; Atherosclerosis

Summary: it is well known that hiv-infected subjects frequently experience hyperlipidemias, insulin resistance, and visceral adiposity, which are known to increase the risk of atherosclerosis. several cohorts have shown an increased risk of heart disease in people with hiv. the effect of hiv treatment versus hiv itself on the incidence of heart disease is unclear. in this study the investigators will assess the effect on carotid imt of the initiation of antiretroviral combinations that are known to have a minimal effect on lipids and insulin resistance. we will also assess the changes in several inflammation and cardiovascular markers,as well as endothelial activation markers,and how these changes relate to therapy-induced changes in immunologic, virologic and metabolic markers.


Eligibility criteria:
inclusion criteria for hiv positive group: * hiv-1 infection * age at least 18 years * naïve to antiretroviral therapy * cd4 cell count \> 400 cells/mm3 for controls: age at least 18 years, no known hiv infection, and no known medical condition requiring chronic use of prescription medications. exclusion criteria (both groups): * diabetes * pregnant or breastfeeding * women of child bearing age who refuse or are unable to use appropriate methods of contraception during the entire study period. * active infectious or inflammatory condition * in jail or involuntarily incarcerated

Keywords: hiv imt coronary treatment naive
the swedish two-county trial of mammography screening

Conditions: Breast Neoplasm Female

Summary: population-based randomized controlled trial carried out in two swedish counties, dalarna and ostergotland to find out the impact of early detection on mortality from breast cancer.

the swedish two-county study is a randomized controlled trial of invitation to mammography screening. the trial took place in kopparberg (w), now called dalarna, and ostergotland counties in sweden. the trial randomized 77,080 women aged 40-74 years to invitation to screening (active study population, asp) and 55,985 women to no invitation to screening (passive study population, psp). the trial started in 1977 in w-county and in 1978 in e-county. women in age 40-49 years were invited to single-view mammography screening on average every 24 months, and women aged 50-74 years on average every 33 months. approximately seven years after randomization a significant 31% decrease in breast cancer mortality was observed in the asp group, whereupon the psp was invited to screening once and the screening phase of the trial ended. the mortality data have been reported every two years during the follow-up period and published in peer-reviewed medical journals. the investigators have follow-up data to the dec 31 2015. the 29-year follow-up data has been published in 2012 in radiology. publication of the long-term data reflects the fact that deaths avoided by early detection include some that would have occurred a considerable time later than the screening.

Eligibility criteria:
inclusion criteria * female * aged 40-74 * no history of breast cancer exclusion criteria • breast cancer diagnosis prior to randomization
opioid study - pain with osmotic dilators

Conditions: Abortion in Second Trimester

Summary: comparison of pain levels and pain medications utilized following insertion of two different types of osmotic dilators.

this is a randomized controlled trial to assess and compare pain levels and pain medication needs following placement of laminaria versus dilapan-s for cervical preparation prior to second-trimester dilation and evacuation (d\&e) procedures. pain levels and medication usage will also be assessed following the d\&e procedure itself, up to 7 days after the procedure.

Eligibility criteria:
inclusion criteria: * scheduled d\&e for 15+0 to 23+6 wga * ability to speak and read in english * ownership of smartphone with internet access and data plan exclusion criteria: - chronic pain, fibromyalgia, active pelvic infection, inability to take nsaids, current use of narcotics