Kornimate/medical-research-clean huggingface dataset:
whey protein intake with and without exercise on visceral fat: the p+rise study

Conditions: Obesity; Overweight

Summary: dietary manipulation is proving to be an effective lifestyle strategy to combat the obesity epidemic. increased dietary protein is one effective strategy. for example, increased whey protein ingestion with and without exercise training is associated with enhanced weight loss, body composition and subjective hunger in overweight and obese individuals. our findings suggest that the effects of whey protein ingestion occur independent of a calorie-restricted diet and to a greater extent in individuals following a combined exercise program of resistance exercise, sprint intervals, stretching/yoga/pilates, and aerobic exercise training compared to standard resistance training.

this study was a 16 week whey protein and exercise training intervention in middle aged overweight/obese adults. subjects were randomized into 3 groups: whey protein only consumed as 20 grams per serving three times per day (total 60 grams per day) (wp); whey protein and resistance exercise training (wp-rt); and whey protein and combined exercise training (p+rise). all outcomes, including the primary outcome of visceral fat was measured at baseline (week 0) and post-intervention (week 17) in all study subjects.

Eligibility criteria:
inclusion criteria: * healthy, overweight or obese, inactive exclusion criteria: * smoker, exercise-trained, recent weight loss, heavy caffeine-consumer

Keywords: whey protein intake obesity visceral fat resistance exercise training sprint interval training endurance exercise training yoga training healthy eating healthy lifestyle strategies leptin hunger
the predictors of depression and burnout among surgical residents: a cross-sectional study from kuwait

Conditions: Burnout

Summary: to assess the prevalence and risk factors for depression and burnout among residents across surgical specialties in kuwait.

this is a questionnaire based cross-sectional study conducted in kuwait from jan 2021- february 2021 an online questionnaire was sent to the residents enrolled to the surgical residency programs in kuwait. residency training in kuwait provides programs in both medical and surgical specialties. specialties included in our cohort were: general surgery, orthopedic surgery, urology, neurosurgery, obstetrics and gynecology and otolaryngology. the email sent to our participants included an invitation letter detailing the reason behind the questionnaire and that it is confidential and anonymous. consent was obtained from participants. variables: variables collected included; age, gender, marital status, smoking history, exercise, specialty, year of training, on-call frequency, assessment of burnout and assessment of depression symptoms.

Eligibility criteria:
inclusion criteria: - residents enrolled in surgical training in kuwait. across all surgical specialties from r1-r5 exclusion criteria: recently accepted candidates that have not yet started residency.
comparison of 2 mattresses for the prevention of bedsores by measuring skin pressure in the sacral area

Conditions: Pressure Ulcer

Summary: the main objective of this study is to compare the airsoft duo and the sentry 1200 constant pressure mattresses in terms of peak skin pressures measured at the sacral area.

the secondary objectives of the study are to compare the two devices in terms of: a. body contact surface area. b. peak pressure at the heel area (combining right and left heels) c. occurrence of pressure ulcers anywhere on the body for 1 month d. patient comfort rated at 1 month (visual analog scale varying from 0-10) e. noise (likert scale). f. sleep quality (visual analog scale varying from 0-10).

Eligibility criteria:
inclusion criteria: * the patient must have given his/her informed and signed consent * the patient must be insured or beneficiary of a health insurance plan * the patient spends more than 12 hours in bed and verticalisation is possible * the patient has a stable medical condition (no complication in the last 10 days) and no visible pressure ulcers * the patient is at risk for pressure ulcers as assessed by a score ≤ 15 on the braden scale * the patient weighs less than 120 kg exclusion criteria: * the patient is in an exclusion period determined by a previous study * the patient is under judicial protection, under tutorship or curatorship * the patient refuses to sign the consent * it is impossible to correctly inform the patient * the subject has a contra-indication for a strictly supine position * the patient has a knee flexion deformity \> 10 ° * the patient is in a state of agitation or refuses to cooperate * the patient's weight is greater than 120 kg * the length of stay is less than one month

Keywords: bedridden
flow augmentation study in postthrombotic patients

Conditions: Postthrombotic Syndrome

Summary: rationale: stent therapy has been proven to be an effective form of therapy in the treatment of chronic iliofemoral and iliocaval post-thrombotic obstruction. during the first post-intervention day intermittent pneumatic compression stockings (ipcs) are necessary to augment venous flow. this will inherently prevent early stent occlusion. our aim is to investigate whether the geko device is effective as ipcs regarding augmentation of flow in post-thrombotic patients during the first day after stenting. objective: the primary objective of this study is to identify whether the geko system is effective in augmenting flow compared to ipcs in post-thrombotic limbs before after stenting. study design: interventional pilot study with randomized cross-sectional design. study population: patients with a post-thrombotic obstruction undergoing a percutaneous procedure (pta, stenting). intervention (if applicable): treatment with intermittent pneumatic compression stockings (ipcs) and geko-device. main study parameters/endpoints: the main endpoint and parameter of this study is time-averaged maximum flow velocity (tamfv), measured by duplex ultrasonography using its pulse wave doppler function.


Eligibility criteria:
inclusion criteria: * post-thrombotic obstruction that requires percutaneous intervention through stenting, minimally 18 years of age exclusion criteria: * peripheral arterial disease, comorbidities leading to impaired muscle function of either lower limb, co-morbidities affecting the circulatory system, history of deep venous surgery in either lower limb or groin, allergies to the plasters, pregnancy.
using glialia for treating persistent perceptual postural dizziness

Conditions: Persistent Postural Perceptual Dizziness

Summary: this pilot study will involve 30 participants recruited from the santa lucia foundation irccs, including 20 patients diagnosed with persistent perceptual postural dizziness (pppd), and might or might not have previously contracted sars cov2 infection. they who will be randomly assigned to receive either the glialia supplement or placebo. additionally, 10 control participants who have recovered from covid-19 will receive glialia to help assess the influence of previous covid-19 infection on neuroinflammation levels. the study aims to compare baseline neuroinflammation levels between pppd patients and controls, measure changes in neuroinflammation in all groups after treatment and to determine if the reduction in neuroinflammation is more significant in the glialia group compared to the placebo group. the trial will be conducted in a triple-blind manner, ensuring that neither participants nor researchers know the treatment assignments. each participant will receive sachets to be taken daily for 60 days, with the study providing both the glialia supplement and placebo at no cost.


Eligibility criteria:
inclusion criteria for all groups: -age between 18 and 65 years. inclusion criteria for the pppd-glialia group: * diagnosis of pppd; * recovery from covid-19 infection or absence of previous infection. inclusion criteria for the pppd-placebo group: * diagnosis of pppd; * recovery from covid-19 infection or absence of previous infection (matched to the pppd-glialia group). exclusion criteria for all pppd-group: * presence of concurrent neurological and otological disorders other than pppd; * pregnant women. inclusion criteria for the control group: -previous covid-19 infection (matched for timing to the pppd-glialia group). exclusion criteria for the control group: * presence of neurological and otological disorders; * pregnant women.

Keywords: persistent perceptual postural dizziness functional disorder neuroinflammation human palmitoylethanolamide (umpea) neurofilaments balance
evaluation of a nigella sativa extract (10% thymoquinone, nisatol®) in perimenopausal women with metabolic syndrome

Conditions: Metabolic Syndrome; Elevated Blood Pressure

Summary: a prospective, multicenter, randomized controlled study evaluating the efficacy and safety of a nigella sativa extract standardized to 10% thymoquinone (nisatol®) in perimenopausal women with metabolic syndrome. the study will assess changes in metabolic and blood pressure parameters, as well as improvements in menopausal symptoms and quality of life.

this prospective, multicenter, randomized controlled clinical trial aims to evaluate the efficacy and safety of a food supplement containing nigella sativa oil standardized to 10% thymoquinone (nisatol®) in perimenopausal women diagnosed with metabolic syndrome and experiencing climacteric symptoms. fifty participants will be randomly assigned to either the intervention group (receiving 2 softgel capsules of nisatol® daily for 4 months) or a control group following a mediterranean diet. the primary endpoint is the change from baseline in metabolic and blood pressure parameters, including fasting glucose, lipid profile, cortisolemia, uricemia, and systolic/diastolic blood pressure. the study will also assess quality of life using the greene climacteric scale and monitor treatment safety and tolerability. the study addresses the need for non-hormonal, evidence-based interventions for managing metabolic and menopausal symptoms in midlife women.

Eligibility criteria:
inclusion criteria: * perimenopausal women aged 40-60 years * presence of climacteric (menopausal) symptoms * diagnosis of metabolic syndrome, defined as alteration of at least 3 of the following: * systolic blood pressure ≥130 mmhg and/or diastolic ≥85 mmhg * hdl cholesterol \<50 mg/dl * triglycerides ≥150 mg/dl * fasting blood glucose ≥100 mg/dl * uricemia \>7 mg/dl exclusion criteria: * use of hormone replacement therapy (hrt) * presence of neoplastic diseases * presence of liver disease, kidney failure, or diabetes mellitus * drug or alcohol abuse * known hypersensitivity to nigella sativa or any formulation component
strategies for toddler asd with remote-therapy (star) model for asd

Conditions: Autism Spectrum Disorder; Therapy

Summary: the project aims to develop and implement the strategies for toddler autism spectrum disorder(asd) with remote-therapy (star) model for early toddlers with asd in local community sites in shanghai. it's a randomized control trial lasting 3 years. the children will be divided into 2 groups, one for star intervention group and the other for community intervention group. the star intervention group will be performed star other than community intervention.

autism spectrum disorder (asd) brings enormous economic and emotional burdens to families and society with its ever-increasing prevalence. early intervention has been proved as the key treatment to asd. along with increasing number of asd children identified and diagnosed at early stage, the needs for effective early intervention are dramatically increasing. though therapist-delivered intensive programs for toddlers yield substantive developmental gains, they tend to be costly and with extremely limited resource. the lockdowns during the covid-19 pandemic brings even more obstacles for the children and families to get access to the resource of intervention. as such, the traditional intervention models are not fit for wide implementation within the chinese public health systems and pandemic situation. to solve this dilemma, this project aims to develop and implement the strategies for toddler asd with remote-therapy (star) model for early toddlers with asd in local community sites in shanghai. to maximize the intervention effect, the intervention strategies in star model are designed under the naturalistic developmental behavioral intervention (ndbi) framework which are implemented in natural settings targeting at improving social and communicational capabilities. the structure of the star model is with 2 modules and 16 sessions. module i derives from our previous offline parent-tutoring courses with 8 intervention strategy topics combining academic instruction and real child demonstration but modified into on-line version. module ii is designed specifically for long-term consolidation of parents' intervention skills containing 8 biweekly sessions of distance coaching with parents practicing intervention with their children in real time at home.

Eligibility criteria:
inclusion criteria: * children screened as positive for asd. * two-tiered screening process combing level 1(the modified checklist for autism in toddlers-revised/follow-up , m-chat-r/f) and level 2 (the screening tool for autism in toddlers and young children, stat) exclusion criteria: * other neurologic or degenerative diseases; * severe hearing or visual impairment; * genetic anomaly which may affect impact on intervention; * not available for regular intervention and follow-up.

Keywords: autism naturalistic developmental behavioral intervetion intervention
pilot test of computerized met to reduce adolescent alcohol use

Conditions: Alcohol Abuse

Summary: the goal of this project is to conduct a pilot study evaluating feasibility, acceptability, and estimating the effect size of a new computerized motivational enhancement therapy (cmet) intervention for alcohol-involved adolescent primary care patients.

the goal of this project is to conduct a pilot study evaluating feasibility, acceptability, and estimating the effect size of a new computerized motivational enhancement therapy (cmet) intervention for alcohol-involved adolescent primary care patients. the investigators hypothesize that 1) cmet, when added to computerized alcohol screening and brief intervention (casbi), (casbi+cmet) will be feasible and acceptable when used in primary care; and 2) 12- to 18-yr old patients receiving casbi+cmet will have lower rates of any alcohol use, days of alcohol use, drinks per drinking day, and days of heavy episodic drinking, than casbi alone.

Eligibility criteria:
inclusion criteria: * any alcohol use days in the past 90 days * have an email address and internet access at home, school, or library exclusion criteria: * unable to read or understand english * living away at college at the time of the recruitment visit * not available for computer/telephone follow-ups * judged by the provider to be medically or emotionally unstable at time of visit

Keywords: adolescents alcohol abuse drug abuse substance use
breaking of sitting time prevents lower leg swelling

Conditions: Edema Leg

Summary: sitting or standing during a prolonged and uninterrupted period of time is related to negative health outcomes, such as lower extremity swelling. it is unknown if interrupting sedentary behavior by including brief bouts of standing up to the sitting time can attenuate lower leg swelling. thus, our purpose is to examine if breaking sitting time by adding sit-to-stand transitions attenuates or even prevents lower leg swelling, compared with uninterrupted motionless standing and uninterrupted motionless sitting, using localized bioelectrical impedance raw parameters.

increased sedentary behavior has deleterious effects on cognitive function, mental health, physical function, disability as well as quality-of-life. nowadays, prolonged sitting time has been introduced into many situations such as transportation and in the workplace. staying in the same position (e.g., sitting/standing) for a long and uninterrupted period is associated with poorer health-outcomes, increasing the risk for premature mortality. for instance, sitting for a long period of time has been associated with lower limbs edema. this condition causes discomfort and pain, in turn associated with a lower quality-of-life. the literature shows that interruption of prolonged sitting time has a positive impact in several health-related risk factors. however, no studies analyzed the effects of motionless sitting with brief standing bouts on lower leg swelling. thus, the aim of this study is to examine and to compare the effects of standing, sitting and sit-to-stand transitions on lower leg swelling using localized bioelectrical impedance analysis (bia) measurements a crossover randomized experiment was performed among 20 healthy individuals \[age: 27.5±5.9y, 47% females\]. in this study, the participants performed the 3 conditions (randomly ordered): 1) uninterrupted motionless standing; 2) uninterrupted motionless sitting; 3) sit-to-stand transitions (1 minute sitting followed by 1 minute standing). before each condition, a 10-min resting period was performed. total fat and fat-free mass were determined by dual-energy x-ray absorptiometry. localized resistance (r), reactance (xc), impedance (z) and phase angle (pha) were assessed at the baseline, at 10 min and at 20 min for each condition. the researchers hypothesized that interrupting a prolonged sitting position with sit-to-stand transitions will result in greater muscle pump, preventing lower leg swelling.

Eligibility criteria:
inclusion criteria: * bmi ranging between 18.5 to 29.9 kg/m2; * not taking any medications at the time of the measurements; * all women should have a (self-reported) regular menstrual cycle. exclusion criteria: * self-reported inability to stand for 20min without moving the lower limbs * an active smoking status * presence of diabetes

Keywords: bioimpedance raw bia parameters extracellular water expansion sedentary behaviour
severe influenza cohort

Conditions: Influenza; Severe Respiratory Infection

Summary: influenza is a major cause of morbidity and mortality. the investigators first goal is to evaluate soluble hla-g5 isoform serum level as a potential marker of greater risk of death from influenza respiratory illness in adult and pediatric patients hospitalized in reanimation. secondly, the investigators collected respiratory samples in order to study the transcriptomic profiles of influenza-infected patients with severe symptoms.


Eligibility criteria:
inclusion criteria: * patient (adult or pediatric) * hospitalized in reanimation * with a laboratory confirmed influenza * that agree to take part in the study * affiliated to national health insurance for ancillary group : * adult at least 60 years old * presenting at hospital for a blood test exclusion criteria: * non willing to participate * influenza infection with no respiratory symptoms * pregnancy for ancillary group : * presence of immunodepression defined by: * cancer, or cancer cured for less than 2 years * corticosteroids, methotrexate (mtx), anti tumor necrosis factor (tnf), anti-cd20 * infection in progress (fever)
a clinical trial to evaluate the tolerability and pharmacokinetics of ckd-348(2)

Conditions: Hypertension and Dyslipidemia

Summary: a clinical trial to evaluate the pharmacokinetics and tolerability of ckd-348(2)

an open label, randomized, single dose, 2-sequence, 4-period, cross-over clinical trial to evaluate the pharmacokinetics and tolerability of ckd-348(2) with coadministration of ckd-828, d097 and d337 in healthy adult volunteers

Eligibility criteria:
inclusion criteria: 1. healthy adult volunteers aged ≥ 19 years 2. weight ≥50kg (man) or 45kg (woman), with calculated body mass index (bmi) of 18 to 30 kg/m2 3. those who meet the blood pressure criteria during screening tests: * systolic blood pressure: 90 to 139 mmhg * diastolic blood pressure: 60 to 89 mmhg 4. those who have no congenital diseases or chronic diseases and have no abnormal symptoms or findings. 5. those who are eligible for clinical trials based on laboratory (hematology, blood chemistry, serology, urology) and 12-lead ecg results at screening. 6. those who agree to contraception during the participation of clinical trial. 7. individuals who voluntarily decide to participate and agree to comply with the cautions after fully understand the detailed description of this clinical trial. exclusion criteria: 1. those who received investigational products or participated in bioequivalence tests within 6 months before the first administration of clinical trial drugs. 2. those who take barbiturate and any related drugs which may cause induction or inhibition of drug metabolism within 1 month before the first administration of investigational products. 3. those who donated whole blood or apheresis within 8 weeks or 4 weeks respectfully, or received blood transfusion within a month. 4. those who have a history of gastrointestinal surgery except simple appendectomy and hernia surgery. 5. those who exceed an alcohol and cigarette consumption than below criteria * alcohol: man_21 glasses/week, woman_14 glasses/week (1 glass: soju 50ml, wine 30ml, or beer 250ml) * smoking: 20 cigarettes/day 6. those who have any history of diabetic mellitus, nephropathy, biliary obstruction, shock, angioedema, cardiac insufficiency, dihydropyridine sensitivity, unstable angina, hypothyroidism. 7. those who have genetic problems such as galactose intolerance, lapp lactose deficiency or glucose-galactose malabsorption. 8. those who are deemed insufficient to participate in this clinical study by investigators. 9. woman who are pregnant or breastfeeding.
efficacy of bronchial thermoplasty in korean

Conditions: Asthma

Summary: the investigators will find out if bronchial thermoplasty shows efficacy in reducing acute exacerbation and improving quality of life for uncontrolled asthma in korea through this research. us fda approved this procedure and ce mark was taken in europe. many procedure was performed in western countries. korean fda have approved this procedure in 2013. however, no procedure was performed in korea, and the data is rare in asian countries. in this study, investigators will examine the efficacy of this procedure in korean asthmatics.


Eligibility criteria:
inclusion criteria: * 1) eighteen-year-old or older * 2) patients whose asthma is not controlled with more than three months of using high dose inhaled steroids and long acting β2-agonists * 3) patients with pre-bronchodilator fev1 is between sixty and eighty-five% * 4) patients who do not improve through continuous drug uses. exclusion criteria: * 1) presence of a pacemaker, internal defibrillator, or other implantable electronic devices, * 2) known sensitivity to medications required to perform bronchoscopy, including lidocaine, atropine, and benzodiazepines. * 3) patients previously treated with the alair system should not be retreated in the same area(s). no clinical data are available studying the safety and/or effectiveness of repeat treatments. * 4)active respiratory infection * 5) asthma exacerbation or changing dose of systemic corticosteroids for asthma (up or down) in the past 14 days. * 6) known coagulopathy. * 7) as with other bronchoscopic procedures, patients should stop taking anticoagulants, antiplatelet agents, aspirin and nsaids before the procedure with physician guidance.