Kornimate/medical-research-clean huggingface dataset:
evidence-based robot-assistant in neurorehabilitation

Conditions: Stroke; Paresis; Neglect, Hemispatial

Summary: the purpose of this study is to investigate the efficacy, acceptability, and safety of the therapeutic system e-brain for the treatment of stroke-related impairments.

this randomized controlled trial, rct with cross-over design sequentially allocates participants with stroke-related impairment to both a two week course of conventional rehabilitation therapy and a two week course of therapy using the therapy system e-brain (purpose-built therapy system using a socially interactive humanoid robot); participants are randomly allocated to the sequences "conventional =\> robot" or "robot =\> conventional". stroke survivors with one of the target syndromes, i.e. mild arm paresis, or moderate to severe arm paresis, or visuospatial neglect are invited to participate.

Eligibility criteria:
inclusion criteria: * age at study entry ≥ 18 years * stroke (ischemic stroke, non-traumatic intracerebral haemorrhage, subarachnoidal haemorrhage) * incomplete arm paresis (motricity index, arm score \>1 \[min\] and \< 100 \[max\]) or * visuospatial neglect (clinical signs and net subtest "star cancellation" score \< 50) * candidate able to consent and provides informed consent or * legal representative provides informed consent exclusion criteria: * pregnant or breast feeding * obliged to live in an institution by law or public authority * with case presentation arm paresis: another condition that causes arm paresis is present * with case presentation visuospatial neglect: another condition that causes a relevant visual-perceptual deficit that cannot be compensated is present; exception: homonymous visual field deficits are not an exclusion criterion
the predictive value of dynamic changes of cd4+t lymphocytes in primary nephrotic syndrome with infection

Conditions: Nephrotic Syndrome; Infections; Lymphocyte

Summary: the goal of this observational study is to test whether the dynamic changes of cd4+t lymphocytes can predict infections in patients with primary nephrotic syndrome . the main questions it aims to answer are: * whether the dynamic changes of cd4+t lymphocytes can predict infections in patients with primary nephrotic syndrome * effect of different immunosuppressive therapy on the number and function of t lymphocyte subsets in patients with primary nephrotic syndrome participants will be divided into infection group and non-infection group according to whether they are infected


Eligibility criteria:
inclusion criteria: 1. age ≥ 14 years and\<75 years. 2. it meets the diagnostic criteria of primary nephrotic syndrome, i.e. a. a large amount of proteinuria (24h urine protein quantity \> 3.5g/d); b. hypoalbuminemia (liver function: albumin\<30g/l); c. edema; d. the blood lipid is elevated. among them, item a and b are necessary conditions for diagnosis. 3. nephrocentesis pathology indicates the pathological type of nephrotic syndrome (minimal change glomerulonephritis, membranous nephropathy, focal segmental glomerulonephritis, membranous proliferative glomerulonephritis, mesangial proliferative glomerulonephritis). 4. glucocorticoids or corticosteroids combined with immunosuppressants should be used clinically. exclusion criteria: 1. secondary nephrotic syndrome, such as secondary to systemic lupus erythematosus, hepatitis b, hepatitis c, tumor, organic solvent , heavy metal poisoning, etc. 2. patients with tumor and chronic infectious diseases, such as hiv infection, cardiac insufficiency, acute hepatitis, transaminase increase more than twice the normal value, deep vein thrombosis. 3. the subjects were pregnant and lactating women. 4. patients with serious primary diseases such as heart, brain, liver and hematopoietic system. 5. those who can not cooperate, such as the mentally ill. 6. it is known that it is allergic to or has contraindications to any component in glucocorticoid, fk506, mmf and ctx. 7. serum creatinine (scr) \> 265.2 μ mol/l（3mg/dl）。
study in copd patients evaluating the quality of life (trisnooze)

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this non-interventional study aims to collect information on the patient's quality of life, as well as the quality of sleep when stepping up to a fixed triple maintenance therapy (trimbow®) as per physicians' decision, independent from study participation, and to assess its effectiveness in daily life, in general practitioner setting.

this non-interventional study assesses the real-life effectiveness, with focus on patient's quality of life, of the fixed triple therapy trimbow® after stepping up from a dual therapy in clinical practice at first line centres in patients with confirmed chronic obstructive pulmonary disease (copd). data will be collected on availability as per usual care at baseline, 3 and 6 months after inclusion.

Eligibility criteria:
inclusion criteria: * patient has provided written informed consent * patient is aged 40 years or older * current or ex-smokers with a smoking history ≥ 10 pack years * patient is diagnosed with copd, confirmed by post-bronchodilator spirometry (tiffeneau index \<0.7; baseline or older spirometry) * patient is eligible for switch to triple therapy with at least 12 weeks of stable double inhalation therapy (ics/laba or laba/lama) prior to enrolment to the study * patient is starting treatment with trimbow® upon decision by their physician exclusion criteria: * patients who are hypersensitive to one of the active substances or excipients * patients who are treated with triple therapy (via single or multiple inhalers) in the last 6 months prior to study enrolment * patients on ics, laba or lama monotherapy * patients with pneumonia and/or a moderate or severe copd exacerbation not resolved ≥ 14 days prior to screening and ≥ 30 days following the last dose of oral/systemic corticosteroid (if applicable), or a respiratory tract infection not resolved ≥ 7 days prior to screening * patients participating simultaneously to other clinical trials or studies
investigating the relationship between physical function, comorbidity and cytogenetic risk group in older adults with acute myelogenous leukemia (aml)

Conditions: ACUTE MYELOGENOUS LEUKEMIA

Summary: aml is a disease of older adults, with a median age at diagnosis of 67 years . an estimated 13,410 new cases of aml will be diagnosed in 2007. survival for aml is age-dependent, with significantly lower survival rates reported for older adults. seer statistics from 1996-2003 show a 5 year relative survival rate of 34.4% for adults younger than 65 and 4.3% for those ≥65 years of age 1. clinical trials have demonstrated worse survival outcomes in older adults with aml using age cutoffs of 55, 60 and 65 years. older adults have also experienced increased toxicity to standard therapies in clinical trials. chronologic age cutoffs have therefore been used in research and clinical practice due to concerns regarding toxicity associated with treatment. the reasons for the increased toxicity and decreased survival in older adults with aml is incompletely understood and likely multifactorial including both tumor specific and host specific factors. improving understanding of which measurable clinical characteristics predict vulnerability to toxicity will help refine the research and clinical approach to older adults with aml.


Eligibility criteria:
inclusion criteria: * capacity to provide signed protocol specific informed consent * age ≥ 60 years * pathologically confirmed newly diagnosed aml or undergoing workup for suspected aml * planned induction chemotherapy * inpatient status exclusion criteria: * requiring intensive care unit support during initial evaluation * prior therapy for aml * ecog score \>3
development of mental health outcomes following the 2020 petrinja earthquake

Conditions: Mental Health Disorder; Post Traumatic Stress Disorder; Depression; Anxiety; Panic Disorder

Summary: on 29 december 2020, an earthquake struck petrinja in croatia. the aim of this study is to assesses prevalence of symptoms of posttraumatic stress disorder, depression, anxiety, and panic disorder among exposed inhabitants and examine the effect of family therapy on mental health as part of a public health emergency response and rapid assessment.

the strong earthquake measuring 6.4 on the richter scale hit the area of petrinja town in croatia on december 29 2020, causing numerous casualties and widespread material damage. the maximum felt intensity was estimated at viii (heavily damaging) to ix (destructive) on the european macroseismic scale, and it is the worst earthquake in croatia in the last 140 years. since the initial strong earthquake, the petrinja area has been hit by numerous aftershocks, magnitudes ranging from 1.2 to 4.8 on the richter scale, increasing distress of residents and contributing to further damage of houses and buildings. the earthquake and the constant aftershocks caused strong psychological and physiological reactions in children and adults directly affected as well as a large population of people living in the surrounding areas at the time when croatia was facing a second "lockdown" during the covid-19 pandemic. as part of a public health emergency response, we conducted a rapid assessment among survivors in the most severely affected area by the earthquake. findings from previous researches among survivors of natural disasters have been mixed in prevalence of mental health problems and treatments outcomes. the aim of this study is to assesses prevalence of symptoms of posttraumatic stress disorder, depression, anxiety, and panic disorder among exposed inhabitants and examine the effect of systemic family therapy on mental health during the first year following the earthquake. qualitative methodology will be used to augment quantitative findings. the study sample consisted of 350 individuals residing in the earthquake area. participants were selected from total number of patients requested psychological and psychiatric help during first two months after disaster. a follow up study will be conducted at 6 and 12 months to assess the change in their mental health status.

Eligibility criteria:
inclusion criteria: * people were in the earthquake area while it occured exclusion criteria: * people were not in the earthquake area while it occured

Keywords: disaster earthquake mental health family therapy resilience social support systemic psychotherapy narrative psychotherapy
effects of lifestyle walking on blood pressure in older adults with hypertension

Conditions: Hypertension; Aging

Summary: eight out of ten older adults have hypertension in the us, which is a strong risk factor for cardiovascular events. to manage hypertension, regular and structured exercise is effective and strongly recommended regardless of drug therapy. however, structured exercise is often performed in a health club, could be difficult, and warrants caution in older adults with chronic conditions. in contrast, the most common lifestyle physical activity in older adults is walking, which is inexpensive, easy, and safe. recent technological advancement in activity monitoring provides reliable step counts and promotes lifestyle walking. although one of the most popular public health goals is walking 10,000 steps/day, recent studies found that it is unrealistic and difficult to achieve. further, there is very little evidence whether walking 10,000 steps/day is effective, specifically in older adults with hypertension. walking 3,000 extra steps/day 5 days/week is equivalent to meeting the current aerobic physical activity guidelines, as it takes about 30 minutes each day, and is more realistic and achievable. steps/day is easy to understand and captures most physical activities in older adults. however, there are no specific guidelines about how many daily steps are needed for older adults in the current physical activity guidelines. thus, this project is aimed to provide pilot data to answer a simple, but unknown, question about physical activity in older adults: "can increasing lifestyle walking in older adults with hypertension reduce blood pressure? and can older adults maintain a lifestyle walking intervention on their own?". this project will significantly contribute to developing more effective and easy physical activity guidelines for older adults.

all participants will be prescribed a step goal to increase their walking by 3,000 steps/day on 5 days/week for 20 weeks. during the first 10 weeks, support will be provided by research personnel to actively help obtain these goals. during weeks 11-20, participants will be in a self-maintenance phase where no research personnel assistance will be provided to help maintain the extra walking. participants will log their steps every day during the 20-weeks from a pedometer that they will wear daily. participants will assess blood pressure and weight at baseline, 10 and 20 weeks.

Eligibility criteria:
inclusion criteria: * men and women aged 65+ * systolic/diastolic blood pressure of 130-159/80-99 mmhg. participants will be allowed to be on blood pressure medication. * body mass index of 25-40 kg/m2 * non-smokers * sedentary/inactive individuals: not meeting the current aerobic physical activity guidelines of 150 minutes per week over the past 3 months * baseline average daily step count \<8,000 steps exclusion criteria: * any significant mobility limitation because our intervention requires an increase in 3,000 steps per day, which needs to be achievable by the participant. * a stroke, myocardial infarction (heart attack) or cancer diagnosis within the last 6 months.
safety and efficacy study of dual-axis rotational versus standard coronary angiography

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to assess the clinical safety and efficacy of dual-axis rotational coronary angiography (darca) in the diagnosis of coronary artery disease by directly comparing it to standard coronary angiography (sa).

dual-axis rotational coronary angiography (darca) was developed as an innovative adaptation of rotational angiography (ra), but it requires a longer coronary injection compared to standard coronary angiography (sa). the risk of complications from the contrast agent (such as discomfort, warmth, pain, hypotension and bradycardia) is increased with the use of darca. it remains to be evaluated whether this approach is also suitable for coronary angiography, especially using in the patients with complex coronary lesions. previous studies revealed promising results, but the number of patients included did not provide sufficient statistical power to allow a valid comparison of darca with sa. the purpose of this study is to evaluate the feasibility, safety, clinical tolerance, and hemodynamic effect of darca in comparison to the well-established sa.

Eligibility criteria:
inclusion criteria: * age \>18 years old * a clinical indication for diagnostic coronary angiography to evaluate possible cad exclusion criteria: * pregnancy * known allergy to iodinated contrast * renal insufficiency (\>1.5mg/dl) * cardiogenic shock * acute myocardial infarction within one week * prior coronary artery bypass graft treatment * prior percutaneous coronary intervention treatment

Keywords: coronary angiography rotational coronary angiography contrast media radiation
biomarker for infection risk in cll and mm

Conditions: Multiple Myeloma; Chronic Lymphocytic Leukemia

Summary: the aim of this research study is to use advanced immunology laboratory analysis to identify a more precise blood test that will predict infection risk in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (cll/sll) or multiple myeloma (mm).

the goal of this research study is to identify an antigen-specific antibody profiling biomarker associated with increased risk of any infections in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (cll/sll) or multiple myeloma (mm). research procedures including screening for eligibility, clinic visits, and blood tests. this involves performing blood tests which detect antibodies directed against specific pathogens and measure their functional capacity, and collecting information about outcomes in patients. participation in this research study is expected to last 2 years. it is expected that about 150 people cll or mm will take part in this research study, and this will predominantly include people with cll/sll. takeda is supporting this research study by providing funding.

Eligibility criteria:
inclusion criteria: * adults ≥18 years of age. * diagnosis of rai stage i-iv chronic lymphocytic leukemia or small lymphocytic lymphoma or multiple myeloma. * subjects must be able to consent to clinical trial, or documented health care proxy agent able to consent on behalf of participant. exclusion criteria: * subjects must not have received ivig administration within 6 calendar months of registration or have planned immunoglobulin replacement therapy by treating investigator at time of registration. * subjects with chronic lymphocytic leukemia or small lymphocytic lymphoma must not be rai stage 0. * subjects with multiple myeloma must not have smoldering myeloma or solitary plasmacytoma with or without minimal marrow involvement. * subjects must not have undergone prior autologous, allogeneic stem cell, or solid organ transplant. * subjects must not have any active systemic infection requiring ongoing antimicrobial treatment (prophylactic antimicrobial allowed) at time of registration. * subjects must have no known history of hiv, primary immune deficiency disorder, nor be taking a concurrent immune suppressing medication at time of registration. treatment for cll/sll or mm, cll/sll related autoimmune phenomenon, or physiologic dosing of corticosteroids (5mg/day prednisone/equivalent or lower) is permitted.

Keywords: multiple myeloma chronic lymphocytic leukemia
cameroon baptist convention health board chronic hepatitis b cohort study

Conditions: Hepatitis B; Hepatitis B, Chronic

Summary: the natural history and response to therapy of chronic hepatitis b infection in west africa are currently poorly understood. in this study, employees of the cameroon baptist convention health board (cbchb) and spouses who are found to be hepatitis b positive on screening will be offered enrollment. disease monitoring and treatment will be provided following current who guidelines. clinical data will be prospectively recorded for 5 years, and bio-specimens will be frozen for future analysis.

chronic hepatitis b (chb) is common in cameroon, and hepatitis b-related hepatocellular carcinoma is a leading cause of cancer death throughout west and central africa. little is known about the natural history of chb in sub-saharan africa and the long term response to antiviral therapy. the study hypothesis is that these can be determined by prospective follow-up of a population-based cohort. aims, purpose, or objectives: 1. to determine the characteristics of a population of asymptomatic cameroonian adults who work for the cameroon baptist convention health board (cbchb) who have chronic hepatitis b infection. 2. to determine the phase of infection into which these hepatitis b carriers fall. 3. to determine the incidence and risk factors for cirrhosis, decompensated cirrhosis, and hepatocellular carcinoma in this cohort over time. 4. to offer treatment according to a standardized protocol, and to determine the outcome of treatment. 5. to archive serum samples from patients for potential future studies of specific markers associated with hepatitis b and liver disease outcomes. methods: adult employees of the cameroon baptist convention health board (cbchb) and their spouses who are known to be positive for hepatitis b surface antigen (hbsag+) will be offered the enrollment in a cohort study for chb. following enrollment, their stage of disease will be determined using clinical, laboratory and imaging studies. patients will then be followed at regular intervals for 5 years. antiviral therapy will be offered to patients who qualify according to current world health organization guidelines. significance: this protocol will prospectively determine the scope of chb-related illness in an initially asymptomatic, population-based cohort and the outcomes of current who treatment guidelines in this african cohort.

Eligibility criteria:
inclusion criteria: * age at least 18yrs. * cbchb employee or spouse of an employee. * able to provide written informed consent. * willing to comply with follow-up visits. exclusion criteria: * none

Keywords: tenofovir hepatocellular carcinoma cirrhosis
ultrasound versus kinesiotaping in shoulder impingement syndrome

Conditions: Shoulder Impingement Syndrome

Summary: studying the effect of ultrasound and kinesiotaping in shoulder impingement syndrome in reliefing pain and increase range of motion in subjects with shoulder impingement syndrome .

shoulder pain is a common presenting complaint from patients of all ages in daily clinical practice, affecting approximately one-third of individuals during their lifetime. such pain may lead to the impairment of shoulder joint function and to severe reduction in quality of life. shoulder impingement syndrome. ultrasound (us) is a physical therapy agent that is frequently used as an adjunctive treatment for shoulder pain. us has thermal and biophysical ffects which provide analgesia increases nutrition and increases blood circulation. kinesio taping method (kt), has been widely used also for many musculoskeletal diseases including shoulder problems. most of taping methods are aimed to provide a mechanical stimulus for proprioception or to decrease pain by lifting skin and subcutaneous tissues. * to investigate the effect of adding ultrasound versus kinesiotaping to exercise program on pain intensity. * to investigate the effect of adding ultrasound versus kinesiotaping to exercise program on shoulder rom. * to investigate the effect of adding ultrasound versus kinesiotaping to exercise program on shoulder function. * to investigate the effect of adding ultrasound versus kinesiotaping to exercise program on hand strength.

Eligibility criteria:
inclusion criteria: 1. patients with shoulder impingement syndrome from both genders their age will be ranged and divided into three groups from 20-50 years. 2. history of shoulder pain for one month. 3. positive neer's impingement test and hawkin's kiennedy test. 4. provocation of pain above 60 degrees of flexion and abduction. exclusion criteria: 1. history of shoulder girdle fracture, dislocation and surgery 2. diagnosed with frozen shoulder or rotator cuff tear 3. history of cervicobrachial pain 4. any neuromuscular pain in upper limb and use of corticosteroids or pain subsiding medication

Keywords: ultrasound kinesiotaping shoulder impingement syndrome shoulder pain shoulder range of motion