Kornimate/medical-research-clean huggingface dataset:
novel measures and theory of pediatric antiretroviral therapy adherence in uganda

Conditions: HIV-infection/Aids

Summary: current measures of adherence detect problems weeks to months after they occur. because the hiv virus rapidly begins replicating and mutating in the absence of effective antiretroviral therapy, treatment failure may develop before an intervention can be deployed. real-time objective adherence monitoring could redirect efforts from a reactive response to the proactive prevention of treatment failure. because adherence is so closely associated with viral suppression, accurate adherence monitoring could also strategically limit viral monitoring only to those patients at a defined risk for viral rebound. this observational study is assessing a wireless adherence monitoring device and mobile phone-based adherence data collection among caregivers of children under the age of ten years in mbarara, uganda. it involves both quantitative and qualitative measures of the feasibility and acceptability of these measures, as well as circumstances of adherence lapses and other individual and cultural factors affecting adherence. the qualitative data will be used to explore models of adherence behavior, which will likely include the child-caregiver dynamic, the child's mental and physical health, and social support mechanism.

see above.

Eligibility criteria:
inclusion criteria: * age 1 to 10 years * hiv-infected, meeting ugandan criteria for antiretroviral therapy * living within 30 km of mbarara, uganda exclusion criteria: * lack of mobile-phone reception

Keywords: hiv/aids pediatric wireless adherence monitoring hiv infections
the effect of physical activity autonomic response of autism spectrum

Conditions: Neurodevelopmental Disorders

Summary: this study will investigate the effect of physical activity on autism spectrum disorder (asd) in individuals with asd of different age groups through measuring the hemodynamic, heart activity and respiratory system parameters.

one hundred participants will be included in this study. one hundred typically developed children or control group and one hundred children with asd group. the age range of participants will be 4 - 18 years old. the participants in both control and asd groups will be randomly divided into 4 subgroups according to their age (4-7 years old, 7-10 years old, 10-13 years old and, 14-18 years old). also, asd group will be categorized according to the symptoms severity using the childhood autism rating scale (cars). participants will be excluded if they have any intellectual disability (iq ≤ 70), co-morbid medical or psychiatric disorders, pervasive developmental disorders (pdd) or attention-deficit hyperactivity disorders (adhd). they will also be excluded if they are taking any medications which to affect cardiovascular system, respiratory system, or arousal and balance or any other contraindications to exercises. wechsler intelligence scale for children-fourth edition24 will be used to assess the intelligence quotient (iq).

Eligibility criteria:
inclusion criteria: 1. children with asd group with the age range of participants will be 4 - 18 years old 2. typically developed children with the age range of participants will be 4 - 18 years old exclusion criteria: participants will be excluded if they have the following: * any intellectual disability (iq ≤ 70) * co-morbid medical or psychiatric disorders. * pervasive developmental disorders (pdd) or attention-deficit hyperactivity disorders (adhd). * they will also be excluded if they are taking any medications which to affect cardiovascular system, respiratory system, or arousal and balance or any other contraindications to exercises.
tele-navigation of lung cancer screening (tele-navi lcs)

Conditions: Lung Cancer

Summary: adherence to annual follow up is critical to achieving mortality benefits and optimizing cost-effectiveness of lung cancer screening (lcs). however, adherence to lcs follow-up in the real world is suboptimal. using telehealth, the investigators will co-create tele-navigation of lung cancer screening with patients and lcs stakeholders as an intervention to promote adherence of follow-up lcs. the investigators will then implement the tele-navi lcs intervention to a pilot sample of patients and evaluate its feasibility in the primary care setting. the investigators will measure the number of patient participants who completed tele-navi lcs and follow-up lcs within 180 days from tele-navi lcs.


Eligibility criteria:
inclusion criteria: * is eligible for ldct for lcs follow-up * has technology to complete study activities (e.g., video call visit) * english speaker * has undergone lcs at ummh * is overdue for ldct follow-up exclusion criteria: * has previous diagnosis of lung cancer * has active cancer diagnosis * is a nursing home or group care resident * is pregnant

Keywords: lung cancer cancer screening health informatics
quality of life after hysterectomy (adenoqol)

Conditions: Adenomyosis; Quality of Life

Summary: adenomyosis is a disease where ectopic endometrial-like glands affect the muscular wall of the uterus. about 70% of women affected by adenomyosis suffer from dysmenorrhea and menorrhagia. a levonorgestrel-releasing intrauterine device (lng-iud) is the first-choice treatment of adenomyosis, but is not always sufficiently effective in all women. those women often end up removing the uterus (hysterectomy). hysterectomy is clinically regarded to be an efficient and final treatment of adenomyosis, but pelvic pain may also prevail after removal of the uterus. this study aimes to investigate the short - and long-term impact of hysterectomy on quality of life (qol) and sexual function in women with adenomyosis, and further to evaluate if there is any difference compared to women that are removing their uterus due to other benign gynecological conditions.


Eligibility criteria:
inclusion criteria: * premenopausal status defined by having had menstruation within the last 12 months, or age \< 50 years if amenorrhea due to hormonal treatment * hysterectomy planned due to a benign condition * able to communicate in norwegian or english * electronic consent given exclusion criteria: * age \< 18 years, postmenopausal status or no menstrual bleeding for the last 12 months * hysterectomy as part of female-to-male transition * pelvic organ prolapse as an indication for hysterectomy * gynecological cancer suspected at the time of inclusion * not able to communicate in norwegian or english

Keywords: hysterectomy sexual health adenomyosis
evaluation of the effectiveness of the tovertafel system on behavioral disorders

Conditions: Behavioral Disorder

Summary: the prevalence of behavioral disorders is high in patients living in an institutional environment or hospitalized in a long-term care unit. the consequences of these symptoms are not negligible with a faster cognitive decline and a significant impact on the life of the institution and of other patients when the disorders are pervasive and too difficult to manage for the healthcare teams. despite the daily attention paid to these disorders and their causes, especially the environmental ones, the teams are sometimes helpless, the teams are sometimes helpless today to fight against these symptoms, and their management thus constitutes a real challenge. non-drug interventions targeting this problem often require additional training, architectural installations (snoezelen space) and / or are moderately effective. in order to offer a solution that can be used by everyone, that is transportable and based on new technologies, the tovertafel device was created. these are interactive games projected onto a table using a ceiling projector. the light animations invite people to "play with the light" using arm or hand movements. these games stimulate residents' physical activity and encourage interactions between residents and with caregivers. in this study, it is a question of evaluating the effectiveness of the tovertafel device on the frequent behavioral symptoms in dementia (agitation, ambulation, apathy, anxiety), the quality of life of the patients, as well as on psychotropic treatments.


Eligibility criteria:
inclusion criteria: * man or woman aged 60 to 106. * patient living in one of the usld or uhr participating in the project. * score greater than or equal to 9 for at least one of the following items in the npi-es: apathy, agitation, anxiety, depression, aberrant motor behavior. * presence of tnc according to the standardization and calibration of the mmse. * the patients recruited must have given themselves, or through a trusted person provided for in article l. 1111-6 of the public health code, failing this, by the family, or, failing that, by a person having close and stable ties with the person concerned; for adults under guardianship: the guardian or legal representative, for adults under guardianship: the curator, their informed consent to this study which must be approved by the personal protection committee (ppc) prior to its completion. exclusion criteria: * unstable pathology whose nature can interfere with the evaluation variables * deafness or blindness which could compromise the patient's assessment or his participation in the animation sessions.

Keywords: dementia non-drug intervention apathy
medical treatment of solid tumors at the lyon university hospital cancer institute during the first wave of covid-19 in france: a conservative approach

Conditions: Cancer; Solid Tumor; Covid19

Summary: an article to present how cancer patients were taken in charge at lyon university hospital cancer institute (france) during the first peak of the covid-19 pandemic between march and may 2020 is under writing. it will present strategies that were set-up to avoid cross-contamination between patients and caregivers, patients treatment adaptation (timing, dosage,..) and how consultations, multidisciplinary team meetings, surgical procedures and clinical trials were impacted. part of this article will also illustrate the characteristics of patients with a solid tumor(s) that have been hospitalized during this timeframe for the covid-19. how cancer type and stage affect covid severity and mortality.will be described for a small sample of patients (44). these qualitative figures will be compared to literature current state of the art.


Eligibility criteria:
inclusion criteria: * patients with a luhci code created after 2015 and a luhci covid-19 code created between march 2020 and may 2020. exclusion criteria: * patients who did not allow the reuse of their medical file data for research related to covid-19-

Keywords: covid-19 cancer solid tumor qualitative study first pandemic wave
ethosuximide and pentoxifylline in the treatment of abdominal pain related to irritable bowel syndrome

Conditions: IBS - Irritable Bowel Syndrome

Summary: ethosuximide and pentoxifylline in the treatment of abdominal pain related to irritable bowel syndrome

ethosuximide and pentoxifylline in the treatment of abdominal pain related to irritable bowel syndrome: does this add to current treatment?

Eligibility criteria:
inclusion criteria: * • age ≥ 18 years, * man and women, negative pregnancy test and effective contraception, * ibs defined by the rome criteria iv * during the previous seven days the inclusion visit, average numeric rating scale (nrs) pain ≥ 4. * ibs treatment stable for 1 month exclusion criteria: * • breastfeeding * diabetic patients * significant liver function abnormalities (transaminases\> 3n, cholestasis) and moderate renal disease (mdrd \<60 ml / min) * addiction to alcohol and / or drugs, * antiepileptic drugs taken (epilepsy or chronic pain) * chronic pain of greater intensity than that related to ibs, * known allergyto succinimides (ethosuximide, methsuximide, phensuximide) and pentoxifylline. * history or current severe depression (hospitalization, long-term antidepressant treatment) * psychotic disorders,
non small cell lung cancer patients treated with erlotinib six months or longer

Conditions: Non Small Cell Lung Cancer

Summary: with roughly 80% of cancer patients receiving their oncology care in the community setting, the investigators are proposing to sample from a community-based center to evaluate the percentage of epidermal growth factor receptor (egfr)-wild type patients that gain benefit from erlotinib and assess the clinical characteristics that are associated with erlotinib-responders. additionally, biopsy specimens from enrolled patient cases that are egfr-wt will be evaluated via exploratory genetic analysis for correlated markers.


Eligibility criteria:
inclusion criteria: * patients must have had nsclc. * patients must have received erlotinib (single-agent) for six months or longer for nsclc in the second/third line setting or as maintenance therapy. * patients must have tissue available for egfr-mutation status testing (if not previously performed) or egfr-mutation status test results available. * patients must have tissue available for exploratory genetic analysis. * patients must have all clinical information, treatment response data and outcomes data available for review. * patients must be deceased.

Keywords: nslcl erlotinib tarceva
outcomes of mechanically ventilated patients with low serum testosterone

Conditions: Acute Respiratory Failure

Summary: this is a study to determine the testosterone serum levels in male patient with acute respiratory failure requiring mechanical ventilation. the objective is to determine if low levels exist in this population and if it correlates with length of mechanical ventilation. hypothesis: serum testosterone levels in mechanically ventilated male patients are significantly decreased from normal levels and correlate with disease severity and outcomes.

study objectives 1. to confirm and quantify the presence of hypotestosteronemia in critically ill male patients with acute respiratory failure requiring mechanical ventilation via endotracheal intubation. 2. to correlate serum testosterone levels with disease severity, short-term outcomes, and survival in mechanically ventilated male patients. 3. to determine if demographic patient characteristics, such as age, admitting diagnosis, or the presence of co-morbidities, affect serum testosterone levels during mechanical ventilation.

Eligibility criteria:
inclusion criteria: 1. male 2. age \> 18 3. admission diagnosis of acute respiratory failure requiring endotracheal intubation and mechanical ventilation for \> 24 hours 4. apache ii score \> 15 (apache: acute physiology and chronic health evaluation - general indicator of disease severity and outcomes predictor) exclusion criteria: 1. chronic mechanical ventilation (i.e. patients on mechanical ventilatory support for \> 21 days for at least 6 hours per day) 2. patients on mechanical ventilation for \> 48 hours prior to micu admission 3. non-invasive mechanical ventilation 4. patients intubated and mechanically ventilated for drug overdose and anticipated to be intubated for \< 24 hours 5. known diagnosis of hypogonadism (requiring testosterone hormonal supplementation) or currently receiving testosterone therapy or received testosterone therapy within 30 days of micu admission 6. history of testicular, prostate or pituitary tumor 7. chronic use of systemic steroids prior to admission 8. terminally ill patients who are not expected to live longer that 3 months

Keywords: testosterone mechanical ventilation
randomized controlled clinical trial of internal fixation of intertrochanteric fractures of femur guided by conventional versus if-ai artificial intelligence program

Conditions: Hip Fractures

Summary: our team has developed an ai software to guide the surgical protocol for femoral intertrochanteric fractures. this is a prospective randomized controlled clinical study that will include patients with femoral intertrochanteric fractures combining medial posterior and lateral wall fractures, and will randomly divide the patients into a traditional surgical protocol group and an ai-guided surgical protocol group. the efficacy and safety indexes such as operation time, blood loss, operation cost, infection rate, hospitalization time, postoperative pain score, fracture healing time, internal fixation failure rate and mortality rate were compared between the two groups to verify the efficacy and safety of ai-guided surgical treatment plan.


Eligibility criteria:
inclusion criteria: 1. over 60 years old, male or female. 2. osteoporosis intertrochanteric fracture, which met the diagnostic criteria of x-ray intertrochanteric fracture, and osteoporosis t-value \<2.5. 3. patients with 1mm resolution ct imaging data. 4. willing to participate in the project, sign the informed consent, and be able to complete the follow-up work. exclusion criteria: 1. patients with pathological fractures, old fractures, stress fractures, and periprosthesis fractures; 2. patients lacking 1mm resolution ct imaging data; 3. severe malnutrition, heavy smoking, alcoholism and other systemic conditions affect fracture healing; 4. patients with severe medical diseases that cannot be operated on; 5. patients participating in other clinical studies.
treatment of low locally advanced rectal cancer with radiotherapy removal tnt plus neoadjuvant therapy

Conditions: Rectal Cancer

Summary: (1) to evaluate the oncological effects of treatment of low locally advanced rectal cancer with radiotherapy removal tnt plus neoadjuvant therapy tnt plus mode on trg, anal sphincter preservation surgery rate / rectal preservation surgery rate, ccr rate, pcr rate and other oncological effects in patients with middle and low larc; (2) evaluate the r0 resection rate, lars score, urination function and sexual function score, local recurrence rate, and 3-year dfs and os of treatment of low locally advanced rectal cancer with radiotherapy removal tnt plus neoadjuvant therapy tnt plus mode, resolve the current dispute about the treatment of low locally advanced rectal cancer with radiotherapy removal tnt plus neoadjuvant therapy tnt treatment mode of larc, provide a new mode for larc treatment, and hopefully rewrite the diagnosis and treatment guidelines for rectal cancer.


Eligibility criteria:
inclusion criteria: * aged between 18 and 70; * histologically confirmed adenocarcinoma of rectum; * the distance from the lower edge of the tumor to the anus is ≤ 10cm; * ecog score ≤ 1; * have not received any anti-tumor treatment before; * preoperative abdominal enhanced ct or mri showed ct4, cn0-2; m0 chest and abdomen ct showed no obvious metastasis. (note: pet-ct is recommended when small nodules can not be identified by liver or lung ct, and can still be included in the group when considering the possibility of metastasis) * hematological indicators and liver and kidney function within 7 days are within the normal range; * sign the informed consent form and be able to follow the research and /or follow-up procedures. exclusion criteria: * have serious basic diseases, such as heart disease, renal failure, severe liver failure or liver failure, coagulation dysfunction, etc; postoperative recurrence of colorectal cancer; * the patient had a history of malignant tumor within 5 years; * pregnant or lactating women; * the patient has a history of adjuvant radiotherapy for other system diseases, and surgical contraindications, so it is not suitable for surgery; * the patient has had radiotherapy and chemotherapy records before this visit; * distant metastasis was found during operation; * patients with poor radiotherapy compliance and difficult cooperation;
silent breast cancer a study of the disease prevalence held by imaging guided biopsies in autopsy specimens

Conditions: Female Breast Cancer; Male Breast Cancer

Summary: the aim of this study is to define silent breast cancer prevalence in both sexes and will be held by biopsies performed in imaging suspicious areas of the breast (ecography and mammography) in cadavers without known breast cancer.

cadavers of both sexes are going to be submitted to bilateral mastectomy. the specimens are going to be examined by palpation, ecography and mammography and all areas with (breast imaging reporting and data system) bi-rads classification \>= 3 are going to be biopsied. biopsy specimens are going to be processed by the pathology department and cancers are going to be identified and classified by their molecular type. the investigators intend to know which is the disease reservoir in various ages.

Eligibility criteria:
inclusion criteria: * female and male cadavers above 40 years exclusion criteria: * known breast cancer * breast tissue accidental damage
reproducibility of blood flowmetry in human retina using the nidek laser speckle flowgraphy lsfg-navi system

Conditions: Open Angle Glaucoma; Normal Tension Glaucoma; Healthy

Summary: in addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. increasing evidence suggests that in glaucoma patients retinal blood may be decreased.

according to the world health organization (who) glaucoma is the second leading cause of blindness. glaucoma is a global problem, which is becoming even more important as the human life expectancy increases. although the causes of glaucoma are uncertain, mainly intraocular pression (iop), genetics, and ocular blood perfusion pressure in the optic nerve determine the cause of the disease. increasing evidence suggests that in glaucoma patients retinal blood flow is decreased leading to progression and to damage of the optic nerve. in order to measure the peripapillary blood flow a variety of devices using different techniques of flowmetry have been developed. in this study, the reproducibility of the retinal flowmetry measured with the lsfg-navi device from nidek will be investigated. a high reproducibility is crucial for the clinical value of any measuring device.

Eligibility criteria:
inclusion criteria: * signed patient informed consent form * be at least 18 years old * diagnosis of primary or secondary open-angle glaucoma or normal tension glaucoma or healthy controls exclusion criteria: * age \< 18 years * inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant. * no vulnerable participants will be included in this study.

Keywords: glaucoma retinal blood flow ocular perfusion pressure
aerobic exercise on petco2 response in coronary artery disease patients

Conditions: Coronary Artery Disease; Exercise Addiction; Complication, Cardio-respiratory

Summary: the purpose of the present study was to evaluate: 1) the effects of continuous exercise training and interval exercise training on end-tidal carbon dioxide pressure (petco2) response during graded exercise test in patients with coronary artery disease; and 2) examine the effects of exercise training modalities on the association among petco2 at ventilatory anaerobic threshold (vat) and indicators of ventilatory efficiency and cardiorespiratory fitness in patients with coronary artery disease.

end-tidal carbon dioxide pressure (petco2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions. variations in petco2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation. in this regard, it has been shown that patients with cardiac disease have an abnormally low petco2 during exercise, especially those with an impaired response of cardiac output during exercise

Eligibility criteria:
inclusion criteria: * was stable coronary artery disease diagnosed by coronary angiography exclusion criteria: * unstable angina pectoris, * complex ventricular arrhythmias, * pulmonary congestion and * orthopaedic or neurological limitations to exercise

Keywords: coronary artery disease exercise ventilatory efficiency