Kornimate/medical-research-clean huggingface dataset:
effect of cilostazol on endothelial progenitor cells and endothelial function in high risk for cardiovascular disease

Conditions: Cardiovascular Diseases

Summary: 1. the number and function of circulating endothelial progenitor cells (epcs) are inversely associated with coronary risk factors and atherosclerotic diseases. 2. this double-blind, randomized, placebo-controlled trial to evaluate the effects of cilostazol on human early epcs and endothelial function as well as the potential mechanisms of action in patients with high risk for cardiovascular disease.

1. titration of drugs 1. run-in period: eligible subjects are screened and baseline blood samples are obtained 2. study period: 12 weeks * subjects with cilostazol and subjects with dummy placebo * on the first day after the end of the study period, the follow-up data are obtained by the same procedure 3. blood sampling and measurement of serum biomarkers * obtained from peripheral veins in all study subjects at the run-in period and the end of the treatment period of the study * sent for isolation, cell culture, and assays of human epcs * also stored for enzyme-linked immunosorbent assay (stromal cell derived factor-alfa1, adiponectin, soluble thrombomodulin, vascular endothelial growth factor) 2. assays of human epcs 1. colony formation by epcs 2. quantification of epcs and apoptotic endothelial cells 3. chemotactic motility, proliferation/viability and apoptosis assays 3. measurement of flow-mediated dilatation (fmd) of left brachial artery by sonography

Eligibility criteria:
inclusion criteria: high-risk patients who have at least one of the following situations without pre-existing cardiovascular disease including peripheral artery disease or coronary artery disease: * type 2 diabetes mellitus * metabolic syndrome * stage 3 (or more advanced) chronic kidney disease * 2 or more coronary risk factors (male \> 45 years or female \> 55 years, hypertension, tobacco smoking, hyperlipidemia, family history of cardiovascular disease) exclusion criteria: * ankle-brachial index less than 0.9 or more than 1.3 in one or both legs * significant stenosis (more than 50% as compared to reference vessel) in peripheral artery on image study * symptoms suggesting peripheral artery disease in at least one leg * clinical or electrocardiographic evidence of coronary artery disease * clinical evidence of cerebrovascular disease * severe liver dysfunction (transaminases \>10 times of upper normal limit, history of liver cirrhosis, or hepatoma) * left ventricular ejection fraction (\<50% by echocardiography) * documented active malignancy * chronic inflammatory disease * known drug allergy history for cilostazol * current use of cilostazol or any other camp-elevator * premenopausal women

Keywords: cilostazol progenitor cells cardiovascular disease risk factors angiogenesis biological markers endothelial function
moxibustion in a randomized trial for version of breech position from week 32

Conditions: Presentation; Breech, With External Version Before Labor

Summary: moxibustion was tested for version of a breech position in singleton pregnancies. the women were randomized in week 32 to either moxibustion on acupuncture point bl 67 daily in 15-20 minutes or no moxibustion. in week 36-37 the fetal position was checked and external cephalic version was offered for those still in breech position. the randomization was stratified for primigravida and multiparae separately. the randomization was made with a random number even and odd numbers indicating moxibustion or not. the randomization result was hidden in a sealed, non-transparent envelope on the obstetrical department and drawn when the woman gave informed consent to the study.

moxibustion was tested for version of a breech position in singleton pregnancies. the women were randomized in week 32 to either moxibustion on acupuncture point bl 67 daily in 15-20 minutes or no moxibustion. in week 36-37 the fetal position was checked and external cephalic version was offered for those still in breech position. the randomization was stratified for primigravida and multiparae separately. the randomization was made with a random number even and odd numbers indicating moxibustion or not. the randomization result was hidden in a sealed, non-transparent envelope on the obstetrical department and drawn when the woman gave informed consent to the study. sample size calculation gave 45 women in each group, based on alfa 0.05 and beta 20 under condition of a 30 % effect of moxibustion vs. 20 % of spontaneous version in the control group in primiparae and 60 % in multiparae, respectively. thus, 4 times 45 women in each group were sought. only women who had performed three treatments were judged under the principle of intention to treat. exclusion criteria at inclusion in week 32 was bleeding in 2nd and 3rd trimester, placenta insufficiency, cervical shortening, premature rupture of membranes, preeclampsia, elevated blood pressure, pelvic insufficiency, low placental position, uterine malformations, former uterine corrective surgery and known fetal morbidity

Eligibility criteria:
inclusion criteria: * pregnant women with singleton breech position of their babies exclusion criteria: * vaginal bleeding in 2nd and 3rd trimester, placental insufficiency, cervical shortening, premature rupture of membranes, preeclampsia, high blood pressure, pelvic insufficiency, low placental position, placenta praevia, uterine malformations, previous corrective uterine surgery, known fetal morbidity
to study the effects of refractive surgery on oct measurements in the eye

Conditions: Optical Coherence Tomography; Refractive Errors; Myopia

Summary: corrective eye surgeries, such as lasik, are widely used to correct focusing problems such as myopia, or nearsightedness. often these patients develop other conditions like myopic maculopathy or glaucoma which require monitoring with optical coherence tomography (oct). since oct is a light-based test and changes the refractive status of the eye (in the cornea or the lens), it can potentially affect the results of the oct measurements but has not been sufficiently studied. this pilot study aims at studying the potential change in oct parameters in the eye after undergoing such surgery.

refractive surgeries are widely used in patients with ametropia. refractive surgery is most commonly performed in patients with myopia. these patients often have a predilection for developing other conditions in the posterior segment of the eye, like myopic maculopathy or glaucoma which require monitoring with optical coherence tomography (oct). since oct is a light-based test and changes in the refractive status of the eye (in the cornea or the lens) can potentially affect the results of the oct measurements. literature review reveals that the effect of significant changes in refractive power of the eye on the parameters of optical coherence tomography (oct) has not been sufficiently studied. some authors simulated the effect of refractive surgery using a contact lens but had diverging results. this prospective pilot study aims at studying the potential change in oct parameters in the eye after undergoing refractive surgery.

Eligibility criteria:
inclusion criteria: 1. patients undergoing refractive surgery 2. for patients undergoing bilateral eye surgery, the one with higher degree of ametropia will be included. exclusion criteria: 1. astigmatism more than 3 diopters 2. visual acuity worse than 20/25 3. patients with unstable visual fixation 4. severe dry eye
f18-mhf: orthopedic implants-associated infection detection

Conditions: Knee Disease; Knee Infection

Summary: following intravenous injection of \[f-18\]mhf as a bolus, dynamic pet imaging of the lower limbs will be acquired for approximately 90 minutes. the acquired images will be processed and viewed on a mimvista or similar workstation. the uptake pattern of \[f-18\]mhf around infected orthopedic knee implant will be determined and compared with its uptake pattern around non-infected knee implants. this study will look at how \[18f\]mhf goes into normal knee replacements and those with suspected infection.

this is a study that will test a compound (chemical substance) that has a small amount of radioactivity attached to it. this substance has a natural tendency to go to bacterial infections. the substance is called \[18f\]mhf and it is given in the form of an injection into a vein. after the substance reaches the infected body region, scans called pet or positron emission tomography, are done. this is similar to having cat scans or x-rays. usually a compound called \[18\]fdg is used for pet scans to detect bacterial infections but this substance can't distinguish between bacterial infections and inflammation. this substance called \[18f\]mhf does not go to inflamed tissue and may allow bacterial infections to be seen better. this study will look at how \[18f\]mhf goes into normal knee replacements and those with suspected infection. this will hopefully lead to the development of better imaging techniques to look at bacterial infections. \[18f\]mhf is approved by the fda (food and drug administration) for research.

Eligibility criteria:
inclusion criteria for symptomatic patient cohort * patients must be 18 years of age or older, able to provide written informed consent, and ability to lie still for pet scanning. * suspected knee prosthetic infection at least 2 months after original prosthesis placement and who are scheduled to undergo surgery debridement/removal based on the clinical assessment of the referring surgeon. * elevated crp and esr exclusion criteria for symptomatic patient cohort: * undergoing current or recent antimicrobial therapy (within 1 month) * significant comorbidity such as renal failure, septic shock, uncontrolled diabetes * other clinically likely site of infection inclusion criteria for asymptomatic cohort: * patients must be 18 years of age or older, able to provide written informed consent and ability to lie still for pet scanning * knee prosthesis in situ without complications for 6 months or longer exclusion criteria for asymptomatic cohort: * clinical or laboratory suspicion of knee prosthesis infection * recent (within 3 months) or current treatment for infected knee prosthesis * significant comorbidity such as renal failure, septic shock, uncontrolled diabetes

Keywords: implant orthopedic implants implant infection
long-term follow up for retinal vascular changes after endoscopic endonasal pituitary surgery.

Conditions: Pituitary Adenoma

Summary: this study investigates the retinal vascular features, using optical coherence tomography angiography, in patients during one year's follow up after the endoscopic endonasal surgery to remove an intra-suprasellar pituitary adenoma compressing the optic nerve.

the role of the optical coherence tomography angiography to detect the changes in retinal vascular networks in patients after 48 hours and 1 year from the endoscopic endonasal surgery to remove an intra-suprasellar pituitary adenoma compressing the optic nerve. the optical coherence tomography angiography allows a detailed and quantitative analysis of the retinal vascular networks and to follow their changes over time.

Eligibility criteria:
inclusion criteria: * age older than 45 years * diagnosis of pituitary adenoma * treatment-naive with endoscopic endonasal pituitary surgery * absence of other neurological disease * absence of vitreoretinal and vascular retinal diseases exclusion criteria: * age younger than 45 years * no diagnosis of pituitary adenoma * previous treatment with endoscopic endonasal pituitary surgery * presence of neurological disease * presence of vitreretinal and vascular retinal diseases
a cross-functional, population-representative, web-based, epidemiologic study to estimate the prevalence and burden of nocturia due to nocturnal polyuria in the us

Conditions: Nocturnal Polyuria

Summary: to estimate the prevalence of nocturia due to nocturnal polyuria (np) in the us and describe the demographic and clinical characteristics as well as the burden of illness in participants with nocturia due to np.


Eligibility criteria:
inclusion criteria: * at least 30 years of age; * willing to provide informed consent; * able to read us-english or spanish * able to use a computer and access the internet. exclusion criteria: * symptomatic acute urinary tract infection (uti) (experiencing symptoms such as pain or burning when you urinate, strong and frequent urge to urinate, or cloudy, bloody, or strong-smelling urine); * currently pregnant or ≤12 months postpartum; * recent surgery in the last \<6 months; * current lifestyle that leads to irregular or atypical circadian patterns (e.g. employed in overnight shift work) * prior yougov survey participation in past two weeks

Keywords: bladder diary
acute subcutaneous semaglutide in acute ischemic stroke

Conditions: Acute Ischemic Stroke

Summary: can semaglutide help reduce the damage caused by a stroke? asset trial is a national, multicenter, clinical trial, investigating the safety and efficacy of semaglutide in non-diabetic patients with acute ischemic stroke. stroke is a worldwide leading cause of long-term disability and death. in the most common type of stroke (ischemic stroke), a blood clot obstructs an artery in the brain, and thereby prevents oxygenated blood from reaching an area of the brain. brain cells are particularly vulnerable to the lack of oxygen. in the areas most severely affected by a stroke, brain cells die after 5 minutes. as more time pass, the affected area expands, and more brain cells perish. today, efficient treatments aiming at reestablishing the flow of blood by either breaking down the blood clot (thrombolysis) or removing the clot (thrombektomi) are used. however, a significant amount of patients undergoing succesful treamtent, still suffer permanent disability following an ischemic stroke. semaglutide mimics a naturally occurring hormone (glucagon-like peptide-1) and is currently used to treat diabetes and obesity. however, semaglutide has also been shown to possess neuroprotective abilities in recent animal studies, where it reduced the damage caused by ischemic stroke in rats. this study sets out to investigate if it's possible to utilize semaglutide, to increase the resilience of brain cells in patients with an acute ischemic stroke, with the aim of bettering their outcome. the participants consist of non-diabetic patients with acute ischemic stroke, who will be randomized to: * treatment with subcutaneous semaglutide, or * no additional treatment (control group) both groups will be treated according to the standard national guidelies for acute ischemic stroke. the two groups will then be compared to see, if patients in the group treated with semaglutide are less impacted by their stroke.

for detailed project description, please refer to the full trial information at the clinical trials information system (see 'more information' below for link).

Eligibility criteria:
inclusion criteria: * male and female patients (≥ 18 years) at the time of signed informed consent/proxy consent * acute ischemic stroke with disabling neurological deficits (defined as an impairment of one or more of the following: language, motor function, cognition, gaze, vision, neglect, or ataxia) * onset/last seen well to randomization \< 4.5 hours * none to moderate disability in daily living before symptom onset (pre-stroke modified rankin scale 0-3) exclusion criteria: * diabetes (known) or plasma/point of care test-glucose \>11.1 mmol/l at admission * bmi\< 22 * history of pancreatitis, medullary thyroid carcinoma * predisposition or known multiple endocrine neoplasia syndrome type 2 (men 2) * short remaining life expectancy (\< 12months) and/or severe neurodegenerative disease * pregnancy or planned pregnancy within 12 months or breastfeeding * renal impairment measured as estimated glomerular filtration rate (egfr) value of \<30 ml/min/1.73 m2
surgical and pharmacological efficacy of knosp grade 0-2 prolactinoma

Conditions: Pituitary Tumor

Summary: the investigators carried out a multi-center comparative study, involving hospitals including the second affiliated hospital of zhejiang university school of medicine, peking union medical college hospital, west china hospital, wenzhou first hospital, and li huili hospital. this study aimed to compare the efficacy of medication and surgery for specific subtypes of microadenomas and clearly defined macroadenomas (knosp grades 0-2), in order to determine which is more effective and which has fewer benefits, thereby enhancing the evidence base.


Eligibility criteria:
inclusion criteria: * prolactin level greater than three times the normal upper limit * mri indicates knosp grade 0-2 pituitary adenoma exclusion criteria: * mri indicates knosp grade 3-4 pituitary adenoma * taking antidepressants or other psychotropic drugs * patients allergic to bromocriptine or cannot tolerate surgery * women defined as surgical infertility (i.e. hysterectomy, bilateral salpingectomy, or bilateral oophorectomy), or amenorrhea for more than 2 years * critical illness patients, such as those with progressive consciousness disorders, cerebral hernias, and other emergency situations

Keywords: pituitary tumor
rehydration following exercise-induced dehydration

Conditions: Dehydration Related to Exercise

Summary: athletes participating in multiple training sessions a day can be at increased risk of suboptimal hydration and heat illness during their second training session, especially when the environment is hot and humid. with the exception of the absolute volume of water delivered by a rehydration beverage, characteristics of the beverage consumed play a role in the recovery and completeness of rehydration. the amount of sodium in the beverage has been shown to be a primary factor in rehydration. recently, an effect of the carbohydrate concentration of the beverage was been reported, with its effects mediated by the renal system in response to elevated serum insulin. the purpose of this study is to compare sodium and carbohydrate effects on rehydration and recovery.

the effectiveness of beverage composition will be evaluated by modifying the sodium content and carbohydrate content of the beverage. hypothesis: completeness of rehydration will be greater in the beverage with higher sodium concentration. it is also hypothesized that electrolyte-carbohydrate beverages will promote rehydration that exceeds that of consuming placebo (water). using a randomized balanced-treatment crossover design, physically trained males (18-35 yrs) will participate in intermittent exercise for 85 to 100 minutes in three experimental trials of variable intensity training in the heat (30 +/-3 c) followed by a rehydration-recovery period. exercise will be done at varying intensities (intermittent intervals) ranging from 50% to nearly 100% of maximum oxygen uptake (max vo2) determined prior to the experimental trials. during the 85 to 100 min of exercise, no fluids will be given during the trial to elicit an acute reduction in body mass of approximately 2.5 to 3% (standardized for each subject). following exercise, 100% of the volume of fluid lost will be replaced with one of the beverages. beverages will be ingested in six aliquots over a 1-hr period given at the end of the trial. retention of fluid will be calculated by measuring volume of urine lost at 30, 60, 135, and 210 min following ingestion of the rehydration beverage. the primary outcome variable is the percentage of fluid retained, i.e., the difference between volume ingested and cumulative urine produced in 3.5 h as a percentage of volume ingested. body mass, urine specific gravity, total body water, and ratings of vigor and affect will be assessed prior to exercise, after exercise in a state of dehydration, and at 210 min post-exercise following rehydration. a one-way anova will be used to test the hypothesis for rehydration, the primary outcome variable.

Eligibility criteria:
inclusion criteria: * male, age 18-35 y, physically fit, and regularly undergoing exercise training particularly but not exclusively in team sports. exclusion criteria: * "yes" on par-q survey, symptoms or signs of exercise intolerance, vo2 max \<50 ml/kg/min, smoker

Keywords: dehydration exercise rehydration sodium water carbohydrate
the effectiveness of probiotics on atopic dermatitis with cow milk allergy

Conditions: Atopic Dermatitis

Summary: there is not enough evidence to support the use of probiotics for prevention or treatment of ad in children in clinical practice. the purpose of this study is to determine whether probiotics is effective in the treatment of atopic dermatitis with cow milk allergy.


Eligibility criteria:
inclusion criteria: * under the 2 years old, 36 children * mild to moderate atopic dermatitis with cow milk allergy * volunteers who agreed by their parents. * the severity of their disease was assessed by modified scorad index exclusion criteria: * severe atopic dermatitis * patients on systemic steroids, immune-suppression or korean herbal medicine during the previous 6 weeks * anaphylaxis, angioedema, or severe allergic reaction to the cow milk * chronic diarrhea

Keywords: atopic dermatitis food allergy probiotics
go-actiwe energy metabolism

Conditions: Overweight and Obesity

Summary: the aim of the present study is to investigate the changes in body composition and the degree of compensation to exercise induced energy expenditure after 1 year of physical activity with either moderate or vigorous intensity in overweight and class 1 obese men and women. the present study is a sub study to main study "active commuting to improve well-being and health in everyday life" (nct 01962259)


Eligibility criteria:
inclusion criteria: * participation in main study (nct 01962259) exclusion criteria: * no participation in main study
open reduction internal fixation of calcaneus fractures with and without bone graft

Conditions: Calcaneus Fractures

Summary: the purpose of this study is to compare patient functional outcomes for surgical fixation of calcaneus fractures with and without tricortical iliac crest bone grafting

this study was designed as a randomized, prospective evaluation of patients who have sustained an intra-articular calcaneus fracture that requires open reduction with internal fixation as the preferred method of treatment. patients who desire to participate in this study will be randomized into one of two groups. group a will be made up of patients that undergo open reduction with internal fixation and tricortical iliac crest bone grafting. group b will consist of patients that undergo open reduction with internal fixation without bone grafting. all other surgical techniques and management of the fracture and patient will remain unchanged.

Eligibility criteria:
inclusion criteria: * intra-articular calcaneus fractures requiring open reduction and internal fixation * adult patient (19 years or older) * mental capacity to comply with post-operative regimen, evaluation and data collection exclusion criteria: * non-operative fractures for primary or secondary reasons * prior surgery to the hindfoot of the involved lower extremity * inability to comply with post-operative regimen, evaluation and data collection * inability or unwillingness to give informed consent

Keywords: calcaneus fractures iliac crest bone grafting open reduction & internal fixation