Kornimate/medical-research-clean huggingface dataset:
measurement and treatment of back pain

Conditions: Back Pain

Summary: the aim of this study was to evaluate the clinical aspects and to investigate the therapeutic effects of combined therapy with laser on back pain.

dysfunctions of the musculoskeletal system are related to physiological, kinesiological and biomechanical factors that result in pain, paresthesia, inflammation, heaviness, fatigue and compression of peripheral nerves. clinical aspects related to back pain were investigated. for treatment, photobiomodulation can be performed with laser equipment that emits red and infrared light, which promotes analgesic and anti-inflammatory effects. mechanical stimulus can be combined with laser to improve therapeutical effects. in this context, the laser was combined with ultrasound, negative pressure and positive pressure to treat back pain.

Eligibility criteria:
inclusion criteria: * volunteers (female and male) * aged between 20 and 60 years * who had medical referral for pain complaint in low back exclusion criteria: * psychiatric illnesses * endocrinopathies * heart diseases * neurological diseases * osteoporosis * cancer * analgesic, anti-inflammatory or muscle relaxant drugs in the last four weeks
the eurosca natural history study

Conditions: Spinocerebellar Ataxia

Summary: the key goals of eurosca-nhs is to determine and compare the rate of disease progression in sca1, sca2, sca3 and sca6 including determination of the order and occurrence of non-ataxia symptoms, assessment of activities of daily living (adl) and quality of life (qol), and identification of predictors of disease progression and survival.

the key goal of eurosca-nhs is to determine and compare the rate of disease progression in sca1, sca2, sca3 and sca6. to this end, a newly developed and validated ataxia scale (scale for the assessment and rating of ataxia, sara) will be used. eurosca-nhs has a number of secondary aims including determination of the order and occurrence of non-ataxia symptoms, assessment of activities of daily living (adl) and quality of life (qol), and identification of predictors of disease progression and survival. substudies will deal with the development of brain atrophy, as assessed by magnetic resonance imaging (mri), progression of peripheral neuropathy, as assessed by nerve conduction studies, and specific clinical aspects of sca.

Eligibility criteria:
inclusion criteria: * progressive, otherwise unexplained ataxia * positive genetic testing for sca1, sca2, sca3, and sca6 * written informed consent by the patient or his legal agent exclusion criteria: none.

Keywords: natural history
"night vision and carotenoids"

Conditions: Macular Degeneration

Summary: vision at twilight and night is more difficult and dangerous for the entire population, even more so for the elderly and especially for the elderly with degenerative disease. multiple worldwide laboratories have demonstrated the ability to raise macular pigment optical density with dietary carotenoids. this proposal further evaluates the relationship between macular re- pigmentation and vision under stressed conditions simulating twilight and night driving.

this is a study of the physiological function of the eyes at night. however, the risk of automobile injury or fatality (driver, passenger or pedestrian) associated with motor vehicle accidents has been determined to increase with age, as a result of the complex interplay of age-related declines in vision, motor and cognitive functioning. however, basic visual function is the foundation for higher order processing whether it is visual spatial or cognitive. four recent studies reflect the cost of poor vision on driving. (www.visionimpactinstitute.org). for example, visual impairment among european drivers was examined in 2422 drivers from 5 european countries. visual acuity, visual field, contrast sensitivity, glare sensitivity, and useful field of view were tested. visual functions not included in the current licensing standards were found to be more impaired among drivers (compared to those functions legally required). elderly drivers are particularly vulnerable to sensory visual impairment when driving at night, as they suffer declines in both contrast sensitivity (cs), glare disability (gd) and glare recovery (gr).6 justification for study involving humans carotenoid science is well developed with respect to the safe utilization of dietary lutein (l) /zeaxanthin (zx) as studied by the national institute of health (nei). the recently published nei areds2 study- may 2013, further substantiated the safety and usefulness of prescribing the carotenoids (10 mg l / 2 mg zx) in patients at high risk of amd. 7 significantly, the average american and veteran population are typically low dose consumer of these carotenoids (1 to 2 mg/day for the average american).

Eligibility criteria:
inclusion criteria: * no significant supplementary carotenoids within last 10 weeks. without significant media opacity, cataract or congenital / acquired retinal disease other than atrophic amd or diabetic retinopathy. minimum 20/25 to enroll. exclusion criteria: * unwilling or medically / psychiatrically unable to take part in a 6 month study. * recent ophthalmologic surgery or treatment. * tricare, retirees \& enlisted navy personnel excluded. already taking an otc product to improve their night vision (containing carotenoids, polyphenols like bilberry).

Keywords: macular disease
medical cannabis during chemoradiation for head and neck cancer

Conditions: Head and Neck Cancer

Summary: the primary purpose of the study is to observe the adherence and health seeking behavior of patients with head and neck cancer (hnc) certified to obtain medically certified cannabis as part of their supportive care regimen undergoing treatment with definitive or adjuvant concurrent chemoradiation (crt).


Eligibility criteria:
inclusion criteria: * patients must have histologically confirmed squamous cell carcinoma of the head and neck region planned for definitive or adjuvant treatment with concurrent radiation therapy and systemic therapy * patients may receive platinum-based chemotherapy or cetuximab concurrently with radiation therapy * age \>18 years and ecog performance status \ 60). * patients must be willing to use medically certified cannabis as directed after study enrollment * patients must be able to read english, spanish, or french fluently * ability to understand and the willingness to sign a written informed consent document. exclusion criteria: * prior diagnosis of cannabis use disorder as defined in the dsm-v * current opioid use disorder on maintenance opioid therapy * current active use of smoked cannabis or cannabis derivatives and unwillingness to cease use of non-medically certified cannabis for the duration of study participation. * history of allergic reactions attributed to compounds of similar chemical or biologic composition to cannabis derivatives * uncontrolled intercurrent illness including, but not limited to, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
comparison of two graft choices in mediale patellofemoral ligament reconstruction (mpfl)

Conditions: Patellar Dislocation

Summary: the purpose of this study is to elucidate surgical techniques for reconstructing mpfl in the treatment of chronic patella instability. the two techniques are conventional technique with the gracillis and screw fixation in the femur which is compared with new technique where the qt tendons and anchor fixation in the femur are used. it would be investigated which technique provides the best stability with the least postoperative pain from the reconstruction and the lowest frequency of patellar reluxation.


Eligibility criteria:
inclusion criteria: * patients between 15 and 40 years of age with chronic tendency to lateral patellar dislocation (defined as 2 or more verified dislocation cases) * the growth zones must be found closed - verified by mri scan exclusion criteria: * patients with known rheumatoid arthritis. * patients with arthroscopically detected osteoarthritis (grade 3 cartilage lesion) * inability to follow a normal rehabilitation regime. * previous ligament surgery in injured knees.
french database of occipital nerves stimulation in the treatment of refractory chronic headache disorders

Conditions: Refractory Chronic Headache Disorders

Summary: the purpose of this non interventional research is to set up a french database, initially for 3 years, of patients suffering from refractory chronic headache disorders (chronic migraine, cluster headache, chronic paroxysmal hemicranias, sunct syndrome, hemicrania continua, cervicogenic headache disorders), and treated by occipital nerves stimulation. every team using this neuromodulation approach in france is likely to participate in the network. fifty patients a year are expected. they will be informed about data which are collected and why they are collected. the data will come from medical files and questionnaires filling out by the patients. the data will be collected on a case report form adapted to each refractory chronic headache disorder. the case report form pages will be faxed to the coordinating team who will enter the data in the database and analyse the data in a descriptive manner. these data are social and demographic data, medical data (headache features, headache functional and emotional impact, medications, and concomitant medical conditions), technical data (kind of electrodes and implantable pulse generator used, stimulation parameters chosen), and safety data. this research should provide an update on practices, an evaluation of the efficacy and long term safety of occipital nerves stimulation, and perhaps help in identifying response predictive factors to this neuromodulation approach.


Eligibility criteria:
inclusion criteria: * patients suffering from refractory chronic headache disorders and treated by occipital nerves stimulation exclusion criteria: * patients who don't agree with participating in the study because the ending of professional confidentiality is required for setting up the database

Keywords: chronic daily headache treated by occipital nerves stimulation peripheral neuromodulation occipital nerves network database
nm32-2668 in adult patients with selected advanced solid tumors

Conditions: Ovarian Carcinoma; Fallopian Tube Carcinoma; Peritoneal Carcinoma; Endometrial Cancer; Adenocarcinoma of Lung; Triple Negative Breast Cancer; Liposarcoma; Leiomyosarcoma; Mesothelioma, Malignant; Adenocarcinoma - Gastroesophageal Junction (GEJ); Adenocarcinoma of the Stomach; Melanoma, Malignant; Renal Cell Carcinoma

Summary: this is a first-in-human, open-label, multi-center, phase 1, dose-escalation study with expansion cohorts to evaluate nm32-2668 for safety and immunogenicity, to determine the maximal tolerated dose and recommended phase 2 dose, define the pharmacokinetics, to explore the pharmacodynamics, and to obtain preliminary evidence of the clinical activity in adult patients with selected advanced solid tumors.


Eligibility criteria:
inclusion criteria: * patients with histologically confirmed, advanced-stage protocol-specified solid tumors. * confirmed ror1 tumor expression. * patients who have undergone at least one prior systemic therapy and have radiologically or clinically determined progressive disease during or after most recent line of therapy, and for whom no further standard therapy is available, or who are intolerable or have medical contraindications to standard therapy. exclusion criteria: * prior treatment with any agent targeting ror1 or prior treatment with a cd3 t-cell engaging therapy. * prior treatment with chimeric antigen receptor (car) cell therapy within 90 days prior to first dose of nm32-2668. * systemic anti-neoplastic therapy within five half-lives or 21 days, whichever is shorter, prior to first dose of nm32-2668. * wide-field radiotherapy (\> 30% of marrow-bearing bones) within 28 days, or focal radiation for analgesic purpose or for lytic lesions at risk of fracture within 14 days prior to first dose of nm32-2668, or no recovery from side effects of such prior interventions.
the effect of 6 weeks saturated and polyunsaturated high-fat diets on insulin sensitivity and health parameters

Conditions: Insulin Sensitivity

Summary: the aim of the intervention is to gain insight into the long term effect of dietary fatty acid quality on insulin sensitivity and health parameters in healthy men. whole body and peripheral insulin sensitivity were measured, together with analyses of plasma hormones and metabolites. the plasma proteome was also analyzed. molecular adaptations in skeletal muscle and adipose tissue were subject for investigation. furthermore, gut microbiota population number and diversity will be analyzed from faeces samples obtained before and after the intervention.

two experimental diets with a high fat content (65 e% fat), enriched in either saturated or polyunsaturated fatty acids, were provided for 6 weeks to healthy men, in a randomized controlled intervention study with two arms. healthy, untrained, non-obese male subjects (27-45 years) were included in the study. the experimental diets are eucaloric, and thus provided so the subjects remains weight stable. before and after the intervention, two experimental days was conducted (2 experiments before and 2 experiments after the intervention). at pre-intervention, subjects completed a high-fat meal test and insulin sensitivity was measured by the hyperinsulinemic-euglycemic clamp. on both days, blood and tissue biopsies were obtained. these two experimental days were repeated at the end of the 6 weeks intervention. the hyperinsulinemic-euglycemic clamp was combined with stable isotope infusion (deuterium labelled glucose) in order to measure hepatic glucose production. before the clamp, a catheter is inserted into the femoral vein, to enable measurement of insulin stimulated glucose uptake across the leg. biopsies are obtained by the needle biopsy method from the vastus lateralis muscle and peri-umbilical subcutaneous adipose tissue. blood samples were analyzed for glucose, insulin, inflammatory markers, gut hormones, adipokines, plasma fatty acid composition, and lipoprotein profile. indirect calorimetric was also applied to measure substrate oxidation during the experimental days.

Eligibility criteria:
inclusion criteria: * healthy male subjects * 27-45 years * bmi 22-31 * maximal oxygen uptake \<48 ml/kg/min exclusion criteria: * smokers * use of medication * parents with type-2 diabetes

Keywords: insulin sensitivity high-fat diet
challenges faced by neurophysiotherapist while consultation through tele-rehabilitation

Conditions: Stroke, Parkinson' s Disease, Neurological Impairments, Tele-rehabilitation

Summary: being the most important stakeholder of such a vulnerable population, the neuro physiotherapist faced a lot of difficulties while consulting and assessing patients with neurological impairments. up to our knowledge and search history, this is the first-ever study conducted by us which list out the challenges faced by neuro physiotherapist while teleconsultation mode among indian population.

during the ongoing covid-19 pandemic many neurophysiotherapist opted for telerehabilitation to provide rehabilitation to the patients. this study aims to find out challenges faced by neurophysiotherapist (neuropt) for consultation through telerehabilitation within maharashtra provenance. a total of 103 neuropt within maharashtra provenance were contacted through this online survey. a brief, structured and validated questionnaire was constructed as there is no gold standard questionnaire developed to obtain responses from the neuro physiotherapists opting for telerehabilitation mode for their consultations with their clients. the questionnaire was sent by what's app and email to gather basic information to describe the various challenges in consultation through telerehabilitation.

Eligibility criteria:
inclusion criteria:- a cross-sectional study was carried out to obtain the responses from the neuro physiotherapist practicing within maharashtra provenance. exclusion criteria: * neurophysiotherapist practicing outside of maharashtra provenance
a study to improve physician-youth communication and medical decision making

Conditions: Heart Failure NYHA Class II; Heart Failure NYHA Class III; Heart Failure NYHA Class IV

Summary: the goal of this study is improving patient-centered communication for young people with advanced heart disease.


Eligibility criteria:
physician inclusion criteria: * physician participants will be recruited from the division of pediatric cardiology at the university of michigan. all physicians with dedicated clinical effort will be eligible. * eligible physicians must anticipate remaining on staff \>1 year patient/caregiver inclusion criteria: * patients 12-24 years old with heart failure symptoms meeting criteria for new york heart association (nyha) class ii - iv heart failure * one parent/caregiver of patient participants meeting inclusion criteria will also be eligible physician exclusion criteria: - not a physician at university of michigan in the division of pediatric cardiology patient/caregiver exclusion criteria: * patients with significant cognitive/developmental delay with potential to impact study participation will be excluded from the study due to the focus on physician-youth communication. * parents and parent/caregivers that are non-english speaking will be excluded from this pilot study.

Keywords: caregiver/parent
viral illness in pediatric critical care: incidence timing & severity of associated heart dysfunction & acute kidney injury

Conditions: Heart Failure; Acute Kidney Injury

Summary: the purpose of this study is to be able to better describe the incidence, timing and severity of myocardial dysfunction and acute kidney injury (aki) following a documented respiratory viral illness (rsv, adenovirus, metapneumovirus, parainfluenza, influenza, etc.) in pediatric patients.

this is a single-centre, prospective and retrospective, descriptive data-collection pilot study. prospective data collection: all pediatric patients who are less than 18 years with a confirmed positive respiratory viral swab will be invited to participate. retrospective data collection: the retrospective portion of this study will examine a 5 year period prior to the start of enrollment for the prospective study, with the intention to include all pediatric patients who are less than 18 years with a confirmed positive respiratory viral swab and admitted into the local hospital's picu.

Eligibility criteria:
inclusion criteria: 1. the parent or legal guardian of the pediatric subject must sign the consent form for participants in the prospective portion of the study. 2. the subject must be no greater than 18 years of age, at the time of consent. 3. the subject must be admitted to the local hospital. 4. the subject must have a confirmed positive respiratory viral swab. exclusion criteria: 1. the parent or legal guardian of the pediatric subject is unavailable or unwilling to sign the consent form for participants in the prospective portion of the study. 2. the subject has had previous kidney injury or myocardial dysfunction prior to positive respiratory viral swab. 3. the subject has any previous problems (prior to positive respiratory viral swab) with their heart or kidneys that could compromise the results, in the opinion of the investigator.

Keywords: heart failure acute kidney injury myocardial dysfunction pediatric critical care pediatric intensive care units respiratory virus
ultrasound-guided abdominal wall nerve blockade in laparoscopic surgery for acute appendicitis.

Conditions: Appendicitis

Summary: acute appendicitis is a common disease and usually occurs within the ages of 10-30 years old." ten percent of the population will get this disease during a lifetime." at bispebjerg hospital it is one of the most common acute surgeries performed. though at bispebjerg hospital the surgery is only performed on adults as there is no pediatric ward. the surgical technique is primarily laparoscopic surgery, where the patients have their appendix removed while in general anaesthesia. during the last three years bispebjerg hospital has had an average of 287 patients per year undergoing laparoscopic surgery. from january to the september 2012 a total of 211 patients have had the operation, with 29% having the operation performed during daytime, 48% in the evening and 22% at night. open appendectomy is only performed in cases where laparoscopic surgery is impossible, this is often due to adhesions, scar tissue from former abdominal surgery or peritonitis. the scars from laparoscopic surgery are usually smaller than that from an open appendectomy, but it gives the patient three smaller scars divided on three abdominal quadrants instead of one larger scar on one quadrant. the investigators want to conduct a clinical trial with fifty six patients undergoing laparoscopic surgery due to acute appendicitis. the investigators want to find out if it is possible to improve the post-operative pain management within this very large group of patients undergoing acute surgery. in detail, the investigators wish to explore whether the use of the bd-tap blockade in the abdominal wall on patients undergoing laparoscopic surgery due to acute appendicitis, can anesthetize the patients completely or partially, so they can avoid morphine intake completely or partially during the post-operative phase (12-24 hours). the research project will be a randomized, double-blinded, controlled clinical trial.


Eligibility criteria:
inclusion criteria: * age above 18 years * patients undergoing diagnostic laparoscopy for acute appendicitis * american society of anaesthesiology group 1-3 * general anaesthesia exclusion criteria: * inability to cooperate * inability to understand and talk danish * allergic to ropivacaine * drug and alcohol abuse * pregnancy or nursing

Keywords: laparoscopy adult nerve block ultrasonography
reversibility of brain glucose transport in type 2 diabetes mellitus (t2dm)

Conditions: Diabetes Mellitus, Type 2

Summary: the goal of this clinical trial is to learn about the effects of high blood glucose levels in the brain and assess if the changes seen in individuals with poorly control t2dm can be reversed with good glucose control. the main question\[s\] it aims to answer are: * to determine, whether abnormalities in brain glucose transport seen in individuals with uncontrolled diabetes, can be improved with better glucose control. * assess which factors, (duration of diabetes mellitus (dm) and glycemic control) contribute to changes in glucose transport participants will have: * a screening visit * placement of a continuous glucose monitor (cgm) 2 weeks before the first magnetic resonance spectroscopy (mrs) at week 0 * additional visits/phone calls for intensification of diabetes management and nutrition visits * second magnetic resonance spectroscopy (mrs) at week 12


Eligibility criteria:
inclusion criteria: * provision of signed and dated informed consent form * stated willingness to comply with all study procedures and availability for the duration of the study * male or female, aged 18-60 * medical history for type 2 diabetes * hba1c \> 7.5%, bmi ≥18 kg/m2 * be willing to adhere to the intensification of their diabetes regimen exclusion criteria: * creatinine \> 1.5 mg/dl * hgb \< 10 mg/dl, hematocrit of 37 % for males participants and 33 % for female participants * alt \>3 x uln * untreated thyroid disease, * uncontrolled hypertension * known neurological disorders * untreated psychiatric disorders * malignancy * bleeding disorders * current or recent steroid use in last 3 months * illicit drug use * for women: pregnancy, actively seeking pregnancy, or breastfeeding * inability to enter mri/mrs (as per standard mri safety guidelines).