Kornimate/medical-research-clean huggingface dataset:
pulmonary artery harmonic ace+7 energy sealing in vats lobectomy

Conditions: Lung Cancer

Summary: video-assisted thoracic surgery (vats) anatomical lung resection provides an effective minimally invasive treatment strategy for stage i and ii lung cancer. vats lobectomy is associated with significantly less postoperative atrial fibrillation, blood transfusion, renal failure, and other complications when compared with lobectomy via thoracotomy. although vats lobectomy has been proven to be effective and safe in experienced hands, it is not devoid of risk. intra-operative surgical complications can be at times catastrophic. complications include: pulmonary vascular injuries (pulmonary artery (pa), pulmonary vein) necessitating urgent conversion to open thoracotomy and even death. causes of conversion included pa injury, difficult anatomy, bulky/calcified lymph nodes, and technical problems including stapler misfire. pa injury alone constituted 37.5% of all conversions. proper dissection of all tissue around pa branches is sometime difficult especially in the presence of adhesions or large, calcified lymph nodes and may increase the risk of vascular injury. currently, in spite of being a safe and effective technique in experienced hands, a minority of anatomical pulmonary resections are being performed by vats. in an analysis utilizing the nationwide inpatient sample (nis) database in the united states, only 15% of anatomical lung resections were performed by vats. the technical difficulty and danger of vats lobectomy is directly related to pa branch manipulation, stapling and division. pa manipulation is the main hesitation of many thoracic surgeons regarding the adoption of vats lobectomy. we believe that if we can decrease the manipulation and dissection required by the surgeon on the pa branches, we can make these procedures safe and therefore more prevalent for anatomical pulmonary resections.

this study consists of evaluating the safety and efficacy of energy sealing lobar pa branches for lobectomy in humans. all patients planned to undergo a lobectomy by vats at the chum - hôpital notre-dame will be approached. in our institution, lobectomies are either done open (thoracotomy) or by minimally invasive approach, known as vats (video assisted thoracoscopic surgery). this decision is based on the surgeon, tumor size, tumor localization and patient characteristics. only patients already planned for a vats lobectomy will be approached. potential patients will be selected by going over the operation request forms. patients booked for a vats lobectomy will be approached either in the preoperative clinic or the day before surgery, when admitted. aim is to recruit 20 patients.

Eligibility criteria:
inclusion criteria: * all patients planned to undergo a vats lobectomy at the chum-hopital notre-dame exclusion criteria: * age \> 18 years old * inability to consent to the study

Keywords: vats energy sealing
evaluation of factors affecting diaper dermatitis

Conditions: Diaper Dermatitis

Summary: diaper dermatitis is one of the most common skin problems in infants and children.it is a skin disorder in the perineal , perianal and surrounding area .it frequently occurs also in areas immediately adjacent to the diaper area . diaper dermatitis is caused by lack of fresh air,dampness and irritation.with prevelance from 7-35 % in newborns.this skin disorder typically develops between nine and twelve months of age .

the development of diaper dermatitis is multifactorial . newborn skin exhibits a cutaneous immaturity and an increased susceptibility toward skin barrier disruption or percutaneous absorption. the epidermal barrier function resides in the outermost epidermal layer , the stratum corneum , which is the region of terminal skin differnatiation and is composed of corneocytes . the hydrophobic components of the lipid matrix provide the epidermal permeability barrier and protect against excessive water loss and irritant penetration , whereas the corneocytes and the cornified envelope provide mechanical strength to the stratum corneum. the skin in the diaper area is predisposed to irritation by the prolonged contact with irritants , such as urine and feces as well as by diaper occlusion, with leads to an increase in hydration and skin ph. overhydration promotes degradation of "the brick and mortar" structure of stratum corneum, contributing to impraired barrier function.

Eligibility criteria:
inclusion criteria: * age \<2 years whether male or female. * having diaper dermatitis exclusion criteria: * age \> 2 years .
method-of-use study assessing the effect of naltrexone sustained release (sr)/ bupropion sr on body weight and cardiovascular risk factors in overweight and obese subjects

Conditions: Obesity; Overweight

Summary: the purpose of this phase 3b study is to assess the effects of combination therapy with naltrexone sr/bupropion sr (nb) used in conjunction with a comprehensive lifestyle intervention (cli) and in a manner consistent with its intended use after marketing approval, on body weight and cardiovascular risk factors compared to the effects of usual care in subjects who are overweight with dyslipidemia and/or controlled hypertension or obese. subjects in the nb and cli group are required to undergo an evaluation to continue treatment at week 16. subjects are to be discontinued from full participation if they do not lose at least 5% of their body weight relative to baseline and/or are experiencing sustained increases in blood pressure (systolic or diastolic) of ≥10 mmhg above baseline. at week 26, subjects originally assigned to usual care switch to treatment with nb and cli, and subjects assigned to nb and cli continue treatment for the duration of the study (78-weeks treatment period).


Eligibility criteria:
inclusion criteria: * female or male, 18 to 60 years old * body mass index (bmi) ≥30 kg/m2 and ≤45 kg/m2 for subjects with uncomplicated obesity, or bmi ≥27 kg/m2 and ≤45 kg/m2 for subjects with dyslipidemia and/or controlled hypertension exclusion criteria: * history of type 1 or type 2 diabetes mellitus diagnosis * myocardial infarction within 6 months prior to screening * angina pectoris grade iii or iv as per the canadian cardiovascular society grading scheme * clinical history of large vessel cortical strokes, including ischemic and hemorrhagic strokes (i.e., transient ischemic attack is not exclusionary) * history (within the last 20 years) of seizures, cranial trauma, bulimia, anorexia nervosa, or other conditions that predispose subjects to seizures * past or planned surgical or device intervention (e.g., gastric banding) for obesity * chronic use or positive screen for opioids * regular use of tobacco products

Keywords: obesity, overweight
examination of potassium levels in saliva in esrd patients

Conditions: ESRD

Summary: dialysis patients typically undergo 3 treatments a week every other day with an almost 3 day gap during the weekend. after this gap and before the first dialysis of the week the serum potassium level is expected to be maximal. participants will be recruited from the dialysis clinic at hadassah ein kerem hospital. the research team would personally meet the patients who answer inclusion criteria f and ask whether they wish to participate. each willing participant will undergo sialometry and blood will be drawn from the dialysis connections for cbc and biochemistry to establish a baseline. the study measurements namely sialometry and collection of saliva as well as blood test will be taken before the initiation of the dialysis. blood testing will be done via the laboratories of the hadassah hospital. saliva analysis will be done in the research lab of prof. doron aframian.


Eligibility criteria:
inclusion criteria: * present a predialysis serum potassium level over 5 mmol/l. exclusion criteria: * pregnancy patients diagnosed with a pathology of the salivary glands such as sjogren's syndrome, sialosis, sialadenitis. patients who have received previous radiation therapy to the head and neck region
a study of srp-9005 in limb girdle muscular dystrophy type 2c/r5 pediatric and adult participants

Conditions: Muscular Dystrophies, Limb-Girdle

Summary: this is a study of a single systemic dose of srp-9005 in pediatric and adult participants with limb girdle muscular dystrophy type 2c/r5 (lgmd2c/r5). it is comprised of 2 parts (part a, part b) that will assess safety and efficacy.


Eligibility criteria:
key inclusion criteria: * ambulatory, defined as able to walk without assistive aid, 10mwr \<30 seconds, and nsad total score ≥20 * non-ambulatory, defined as 10mwr ≥30 seconds or unable to perform, and pul 2.0 entry scale score ≥3 * possess 1 homozygous or 2 heterozygous pathogenic and/or likely pathogenic gamma-sg deoxyribonucleic acid (dna) gene mutations as documented prior to pre-infusion screening. results to be confirmed by sponsor at a clia/cap/iso15189 certified laboratory prior to dosing. * have aavrh74 antibody titers \<1:400 (that is, not elevated) as determined by an enzyme-linked immunoassay key exclusion criteria: * has a symptomatic infection (for example, upper respiratory tract infection, pneumonia, pyelonephritis, meningitis) within 4 weeks before study treatment infusion * part a: has left ventricular ejection fraction (lvef) \<50% on the screening echocardiogram (echo) (without use of cardiac medication) or clinical signs and/or symptoms of cardiomyopathy or any history of cardiac disease * part b: has lvef \<40% on the screening echo or clinical signs and/or symptoms of cardiomyopathy * has fvc \<40% of predicted value at screening and/or requirement for nocturnal ventilation * serological evidence of current, chronic, or active human immunodeficiency virus infection, or hepatitis b or c infection or active viral or bacterial infection based on clinical observations * any prior treatment with gene therapy, cell-based therapy (for example, stem cell transplantation), clustered regularly interspaced short palindromic repeats/crispr-associated protein 9 (crispr/cas9), or any other form of gene editing * treatment with human growth factor within 3 months of day 1 * treatment with any investigational medication within 6 months of the screening visit * is unable to undergo or tolerate a cardiac mri procedure for any reason note: other inclusion/exclusion criteria may apply.

Keywords: srp-9005 type 2c/r5 lgmd2c/r5 pediatric non-ambulatory ambulatory phase 1 phase 3
study evaluating oral moa-728 for the treatment of oibd in subjects with chronic non-malignant pain

Conditions: Constipation

Summary: the primary purpose of this study is to evaluate the safety and dose-response relationship of n-methylnaltrexone bromide (moa-728) by observing spontaneous bowel movements in subjects with chronic pain, which is not due to malignant cancer, and who have opioid-induced bowel dysfunction (oibd).


Eligibility criteria:
inclusion criteria: * adult outpatients with opioid-induced bowel dysfunction and chronic pain, which is not due to malignant cancer. * taking oral, transdermal, intravenous, or subcutaneous opioids. * willingness to discontinue all pre-study laxative therapy and use only study permitted rescue laxatives. exclusion criteria: * history of chronic constipation before the initiation of opioid therapy. * other gi disorders known to affect bowel transit. * women who are pregnant, breast-feeding, or plan to become pregnant.
anesthetics and auditory, visceral, and heat evoked potentials

Conditions: Healthy

Summary: the aim of the present study is to investigate and quantify the influence of commonly used anesthetics on auditory and pain evoked potentials.

during surgery patients are exposed to different auditory and sensory stimuli. in this study we investigate the influence of different anesthetics to alertness and nociception. in addition to auditory stimuli (aep as a measure of sedation), contact heat evoked potential stimuli (cheps), and esophageal evoked potentials from the lower 1/3 of the esophagus are measured to quantify the effects of anesthetics. 60 volunteers are enrolled into this study. for each drug, three different levels are measured: * level 1 no medication * level 2 low dose of medication * level 3 light sedation dose (volunteer responds to command) four drugs are measured in the study: propofol, sevoflurane, s-ketamine and remifentanil.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status 1-2 exclusion criteria: * drugs that effect the central nervous system * neurological or psychiatric diseases * contraindications against propofol, sevoflurane, s-ketamine or remifentanil * any damages or loss of hearing * heartburn or any stomach diseases

Keywords: pain ssep cheps propofol sevoflurane s-ketamine remifentanil healthy volunteers
multicomponent intervention to decrease chronic obstructive pulmonary disease (copd)-related hospitalizations

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the investigators' proposed study is a randomized controlled trial that will prospectively examine the effect of a multicomponent intervention on the rate of hospitalizations, daily physical activity, self efficacy and health status in patients who have copd and have been hospitalized because of a copd exacerbation. in the study, a convenience sample of patients recently hospitalized for a copd exacerbation, who meet the selection criteria and agree to participate will be randomized to receive one of the following at the time of hospital discharge: (1) the current standard of care plus a multicomponent intervention (counselor + pulmonary rehabilitation) or (2) the current standard of care without the intervention. this study plans to test the following hypotheses: (1) the primary outcome of the study to be the composite endpoint of death or copd hospitalization (2) time to first rehospitalization will be shorter in the intervention group than the control group (3) at follow-up, the physical activity level measured in terms of the average number of steps and active energy expenditure will be higher in the intervention group than in the control group.


Eligibility criteria:
inclusion criteria: * patients must be ≥40 years old * clinical diagnosis of copd or pulmonary function testing reflecting an fev1/fvc ratio of \<0.70 * current or previous smoker with at least 10 pack-years of cigarette smoking * recently hospitalized for an exacerbation of copd exclusion criteria: * patients with a high likelihood of being lost to follow-up or contact (patients with active chemical dependency, are planning to move out of the state, are not living in the healthcare area, or have no telephone at home). * patents with characteristics that can confound the analysis of the primary outcome (patients who are living in a nursing home, have unresectable lung cancer, or have another advanced neoplasm). * patients with an inability to provide good data or follow commands (patients who are disoriented, have a severe neurologic or psychiatric condition). * patients with an inability to do mild exercise, such as cycling or walking, when their copd is stable (patients who have orthopedic-neurologic problems; patients who have severe heart failure, characterized by an ejection fraction of \<20% or by new york heart association class iv disease; patients who should be at complete rest, confined to a bed or chair; or patients in whom any physical activity brings on discomfort and in whom symptoms occur at rest).

Keywords: chronic disease management physical activity self-efficacy self management
sevoflurane and hyperperfusion syndrome

Conditions: Hyperperfusion Syndrome; Moyamoya Disease

Summary: the aim of the present study is to evaluate the effect of sevoflurane postconditioning on the incidence of postoperative hyperperfusion syndrome following revascularization surgery in moyamoya patients.

postoperative hyperperfusion syndrome is a common complication in moyamoya disease patients receiving revascularization surgery. previously its incidence has been reported to be 17\~50%, but little remains regarding frequency of reperfusion injury after revascularization surgery in patients with moyamoya disease. volatile anesthetics such as sevoflurane has been introduced clinically to reduce reperfusion injury and preconditioning with sevoflurane induced ischemic tolerance like as ischemic preconditioning. however, there was no report on the neuroprotective effect of sevoflurane postconditioning on ischemic/reperfusion injury in human brain. therefore, we evaluated the neuroprotective effect of sevoflurane postconditioning on the incidence of postoperative hyperperfusion syndrome after revascularization surgery in moyamoya disease patients.

Eligibility criteria:
inclusion criteria: * adult patients receiving cerebral revascularization surgery due to moyamoya disease exclusion criteria: * patients who do not agree to the study * patients with uncontrolled diabetes or hypertension * patients using cyclooxygenase2 inhibitor or with previously using cyclooxygenase2 inhibitor * patients with acute renal failure * patients with previous intervention related with moyamoya disease
recruit blood donors via sms during epidemic of covid-19

Conditions: Blood Donation

Summary: the fight against the spread of the 2019-ncov epidemic has achieved some success in china, but the epidemic is far from over. a key factor making the epidemic under control in china is the government's call for social distance, which has led to few people going out for donation. as a result, the number of blood donors on the streets has been continuing to decline. urgent recruitment of blood donors is therefore planned during the period from 30 april to 10 may via emergency recruitment sms . this study has been designed to compare which information extraction frameworks would be more sensitive to blood donors in emergency situations.

researches has showed that that the information extraction and processing in emergency was different from the normal situation. to understand what information the blood donors are more sensitive to in an environment that may pose a potential threat to themselves, this interventional study has been designed. eligible blood donors in guangzhou blood center has been randomly divided into four groups according to their sociological variables, their interval since last blood donation , their history donation times and the location of their last blood donation. three groups of donors has been randomly selected as interventional groups, and will receive three kindly of emergency blood donor recruitment sms respectively. the placebo group donors will only receive a may day greeting sms. one blood donor recruitment sms will emphasize what blood services will do to ensure the safety of blood donors during their donation in 2019-ncov epidemic, one will shows information about a loss-based framework, while the third one will show information about a benefit-based framework .

Eligibility criteria:
inclusion criteria: * blood donors whose last turning up were between october 31, 2016 to october 31, 2019 exclusion criteria: * blood donors who were deferral by blood screening result and other situations. blood donors who have indicated that they would not accept urgent recruitment.
effect of habit-ile on visuo-spatial attention of children with unilateral cp

Conditions: Cerebral Palsy

Summary: this study aims to investigate the changes induced by habit-ile in impairments, activity and participation of children with unilateral cp, as well as neuroplastic changes induced by the treatment. visuospatial deficits will be investigated and the effect of prismatic adaptation will be measured.

this study aims to investigate the changes induced by habit-ile at the 3 levels of the international classification of functioning and health (icf) in children with unilateral cp, as well as neuroplastic changes induced by the treatment. visuospatial deficits will be investigated and the effect of prismatic adaptation will be measured.

Eligibility criteria:
inclusion criteria: * unilateral cp * minimal ability to pick an light object from a table * age 5-18 exclusion criteria: * no active seizure * no botox or orthopedic intervention in the 6 months preceding the study or during the study

Keywords: motor skill learning, visuo-spatial attention
comparison of dry needling and deep friction massage in patients with subacromial pain syndrome

Conditions: Subacromial Impingement Syndrome; Trigger Point Pain, Myofascial

Summary: this study was planned to investigate the effects of trigger point-dry needling therapy (tp-dnt) on night pain and shoulder internal rotation (sir) in individuals with subacromial pain syndrome (sps).

shoulder pain seen intensely in the general population, many methods has been used for the treatment which has not been fully proven to be superior to each other. before considering surgical approaches, trying conservative approaches is emphasized. while literature showed us that nighttime pain is an important musculoskeletal symptom, may be associated with local inflammation, it is an important feature during the treatment planning. tp-dnt had positive effects on night pain and sir in sps. it was seen that the treatment satisfaction level of participants was high. despite these positive findings, there is need for further studies in which sample size is increased, control group is added, and long-term follow-up is planned.

Eligibility criteria:
inclusion criteria: * to be able to read and speak turkish well enough to give informed consent and follow the working instructions. * having complaints of unilateral shoulder pain for at least 6 months and being diagnosed with subacromial impingement syndrome. * having night pain * having active trigger point. exclusion criteria: * bilateral shoulder pain * if there is a contraindicated condition for needles such as fear of needles or infection * history of bleeding disorder * shoulder fracture and / or dislocation history * symptoms of cervical radiculopathy and / or neuropathy * the use of antiaggregants, anticoagulants, analgesics or antiinflammatory drugs or drug-like substances (1 week before or during treatment) * fibromyalgia syndrome * any neurological, motor, or sensory disorder in the upper extremity * history of surgery on shoulder or neck * conservative or invasive physical therapy or infiltration for the shoulder region during the last 6 months * pregnancy

Keywords: dry needling, subacromial joint, night pain