Kornimate/medical-research-clean huggingface dataset:
intracoronary features in the prognosis of endothelial dysfunction and maces in population with acute coronary syndrome

Conditions: Endothelial Dysfunction; Cardiovascular Risk Factor; Coronary Syndrome, Acute

Summary: coronary artery disease (cad) is common in mexico, while morbidity and mortality is high. drug therapy can relieve angina pain and stabilize plaque, but it is not able to re-flow a coronary artery. balloon angioplasty and/or stent placement, re-establishes coronary blood flow; however, the risk of re-stenosis and/or development of new coronary events remains latent. endothelial damage, reflected by the degree of endothelial dysfunction, inflammation and oxidative stress, promotes atherogenesis, which plays a central role in the pathophysiology of cad. these mechanisms have been studied in animal models; however, it is widely unknown whether it influences the coronary circulation in humans. therefore the present study explores the impact of an intracoronary profile of biomarkers of endothelial dysfunction, inflammation and oxidative stress on the prognosis of coronary remodeling and new adverse cardiovascular events in patients with chronic stable coronary syndrome undergoing angioplasty and stent placement.

study design: observational, longitudinal, analytic and prospective cohort study. .with the ethics and institutional investigation committee acceptance, patients with stable coronary plaque or post-infarct angina with indicated coronary angiography and stent placement, from the hemodynamic unit from the national medical center "20 de noviembre" of the institute of security and social services of state workers (issste) are invited to participate. patients who agree to participate in the study sign the informed consent. the independent variables will be the coronary profile components (oxidative stress, inflammation and endothelial disfunction biomarkers) and the consequence variables (dependent) will be the coronary and/or stent remodeling during the post-angioplasty with stent placement monitoring, major adverse cardiovascular events (mace) during the post-angioplasty with stent placement monitoring period. clinical data: to homogenize the study population respect to potentially confusing variables, information about sex, age, body mass index, vital signs. lipid profile. co-morbility presence like systemic arterial hypertension, diabetes mellitus, metabolic syndrome, drugs and troponin determination for stratify the acute coronaropathy. coronary catheterization and sampling. the coronary catheterization (angioplasty with stent placement) is made under medical indication. -coronary catheterism: is made in the hemodynamic laboratory. asepsis, antisepsis and local anesthesia are performed in the intravascular approach area.

Eligibility criteria:
inclusion criteria: * coronary syndrome patients * patients with endothelial dysfunction exclusion criteria: -

Keywords: mace epcs cardiovascular risk endothelial dysfunction prognosis
feasibility of at-home chair-based resistance band training to improve balance, strength, and bone density in older adults

Conditions: Sarcopenic Obesity

Summary: the purpose of this study is to determine the feasibility of implementing a 24-week at-home chair-based resistance band training intervention, to determine effectiveness of a the a 24-week at-home chair-based resistance band training intervention in improving body composition and to determine the effectiveness of a 24-week at-home chair-based resistance band training intervention in improving physical performance in adults 50 years and older, receiving care at the ut physicians center for healthy aging.


Eligibility criteria:
inclusion criteria: * english-speaking * receive care at the ut physician center for healthy aging exclusion criteria: * inability to provide informed consent on their own * presence of obvious signs of cognitive decline * a diagnosis of dementia and inability to come to the clinic for the scheduled study visits.

Keywords: chair-based resistance band exercise
the therapeutic effect of dau-di-wu-gong in patient with ankle fracture

Conditions: Ankle Fractures

Summary: ankle fracture is one of most common bone fracture in taiwan, although ankle fracture can be treated by surgical operation, local edema, pain and wound poor healing always is noted, according to the investigator's knowledge, no good therapeutic methods to treat mention-above symptoms until now. helminthostachys zeylanica(l.)hook, also called dau-di-u-gon has anti-inflammation, calm down heat and detoxication, and anti-edema. people in taiwan often uses helminthostachys zeylanica(l.)hook to treat bone and tendon pain, and its ugonin component of helminthostachys zeylanica(l.)hook also is proved that has analgesia and ant-inflammation. therefore, the purpose of the present study was to design a randomized, double-blind, controlled study to evaluate functional recovery effect of helminthostachys zeylanica(l.)hook after surgical operation in patients with ankle fracture.

the purpose of the present study was to design a randomized, double-blind, controlled study to evaluate functional recovery effect of helminthostachys zeylanica(l.)hook after surgical operation in patients with ankle fracture. the primary outcome measure was the scores change of american orthopaedic foot and ankle society (aofas) ankle-hindfoot scale, and tape (figure-of-eight) methods. secondary outcome measure was the level changes of bone metabolism in peripheral blood, four diagnostic method, and the changes of ankle x-ray findings.

Eligibility criteria:
inclusion criteria: * 20-75 year-old male or female with acute ankle fractures with surgical indication (joint line displacement \>2mm ; fracture dislocation) exclusion criteria: * previous skin disease, dm or peripheral vessel disease with local foot amputation. * previous ankle surgery, old ankle fracture, or open fracture. * liver or renal dysfunction, and cardiorespiratory failure. * surgical infection after surgery. * patient refuse or can't finish the treatment course * patient with cancer * pregnancy * hiv positive.

Keywords: ankle fracture helminthostachys zeylanica(l.)hook clinical trials functional recovery
molecular mechanisms underpinning sarcopenic obesity

Conditions: Sarcopenic Obesity; Obesity; Sarcopenia; Aging

Summary: the coexistence of obesity and sarcopenia results in sarcopenic obesity, a high-risk geriatric condition associated with metabolic perturbations and several co-morbidities. despite the rising numbers of older adults diagnosed with sarcopenic obesity, few studies have characterized this condition on the muscle cell and systemic level. this study sought to comprehensively assess the influence of sarcopenic obesity on muscle and blood-related parameters and compare it to non-sarocopenic obese and non-sarcopenic lean older adults.


Eligibility criteria:
inclusion criteria: * body fat % in accordance with previously defined criteria * free of smoking (since 10 years) * able to walk without assistance * able to perform bilateral leg extension exercise exclusion criteria: * history of or present disease of myocardial, vascular, endocrine, hepatic, renal, pulmonary or neuromuscular origin * uncontrolled hypo/hypertension * use of anticoagulants (warfarin, trombyl) * use of metformin or other anti-diabetic medications * poor appetite and unexplained weight loss (4,5 kg) over the past 6 months * active malignancy * present infection * dementia or delirium * other conditions that may interfere with the study protocol in the opinion of the pi
the effects of huang-lian-jie-du-tang（hljdt) on the survival of patients with multiple myeloma in maintain therapy

Conditions: Multiple Myeloma

Summary: to investigate the efficacy of the combination of thalidomide and huang-lian-jie-du-tang on the patients with multiple myeloma in maintain therapy.


Eligibility criteria:
inclusion criteria: * patients can take hljdt exclusion criteria: * patients can not take hljdt
the role of antioxidant supplementation in keratoconus patients

Conditions: Keratoconus

Summary: keratoconus is the most common primary cornea ectasia, where the cornea undergoes structural changes, leading to loss of tissue integrity and vision loss. the prevalence of keratoconus is 1:2000 in the general population. oxidative stress has been thought to have a major effect in the disease pathogenesis of keratoconus. in vitro studies have shown increase in metabolites related to oxidative stress in keratoconus disease, and that keratoconus cells undergo increased oxidative stress and tissue damage. animal models have shown a therapeutic effect of vitamin c (ascorbate) in corneal wound healing. glutathione and vitamins a, c, and e are important antioxidants in the human body. to this date, the role of systemic antioxidant supplementation in keratoconus patients has yet to be studied. in addition, it has yet to be established as to whether there is a correlation between serum antioxidant levels, and the severity of disease in the keratoconus patient. the investigators propose to investigate the plasma levels of antioxidants in relation to disease severity. the investigators will also investigate the role of antioxidant supplementation-consisting of parenteral glutathione (gsh), and vitamins a, c and e-in delaying the disease progression in keratoconus.


Eligibility criteria:
inclusion criteria: * participants would be without illness or condition that could make follow-up, or compliance with study medication difficult. * participants may have a prior diagnosis of keratoconus, or may be diagnosed at the initial visit. * participants should not have an eye diagnosis, other than keratoconus, that could adversely influence the visual acuity. * these participants must not have had prior surgical procedure to treat keratoconus, including collagen cross-linking, intacs ring segments, or corneal transplantation. exclusion criteria: * would exclude smokers and former-smokers.

Keywords: keratoconus progression vitamins and keratoconus vitamin supplementation
the effect of insulin degludec in combination with liraglutide and metformin in subjects with type 2 diabetes qualifying for treatment intensification

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in africa, asia, europe and north america. the purpose of the trial is to investigate the effect of insulin degludec (ideg) in combination with liraglutide (lira) and metformin (at least 1500 mg daily or maximum tolerated dose) in subjects with type 2 diabetes qualifying for treatment intensification.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * insulin naïve * ongoing treatment with metformin or metformin in combination with either sulphonylurea (su), glinides, dipeptidyl peptidase-iv (dpp-iv) inhibitors or exenatide (only twice daily (bid)) * glycosylated haemoglobin (hba1c) (by central laboratory analysis): a. 7.5-10.0 % (both inclusive) for subjects on metformin monotherapy, b. 7.0-9.0 % (both inclusive) for subjects on metformin in combination with either su, glinides, dpp-iv inhibitors or exenatide (only bid) exclusion criteria: * treatment with glucose-lowering agent(s) other than stated in the inclusion criteria within 12 weeks * calcitonin equal to or above 50 pg/ml * stroke; heart failure new york heart association (nyha) class iii or iv; myocardial infarction; unstable angina pectoris; or coronary arterial bypass graft or angioplasty; all within 24 weeks * current or past (within the last 5 years) malignant neoplasms (except basal cell and squamous cell carcinoma)
the rise trial: a randomized trial on intra-saccular endobridge devices

Conditions: Intracranial Aneurysm; Brain Aneurysm; Unruptured Cerebral Aneurysm; Ruptured Cerebral Aneurysm; Cerebral Aneurysm

Summary: intracranial bifurcation aneurysms are commonly repaired with surgical and with endovascular techniques. wide-necked bifurcation aneurysms (wnba) are a difficult subset of aneurysms to successfully repair endovascularly, and a number of treatment adjuncts have been designed. one particularly promising innovation is the web (woven endobridge), which permits placement of an intra-saccular flow diverting mesh across the aneurysm neck, but which does not require anti-platelet agent therapy. currently, which treatment option leads to the best outcome for patients with wnba remains unknown. there is a need to offer treatment with the web within the context of a randomized care trial, to patients currently presenting with aneurysms thought to be suitable for the web.


Eligibility criteria:
inclusion criteria: * patient with an intracranial aneurysm in whom web is considered an appropriate therapeutic option by the participating clinician * aneurysm of maximum diameter of 4-11 mm * may include (but are not restricted to) saccular bifurcation aneurysms of the middle cerebral artery, basilar bifurcation, carotid terminus, or anterior communicating artery aneurysms * recurring, persistent aneurysm after previous treatment can be included so long as the treating physician judges the aneurysm morphology to be appropriate. * ruptured aneurysms with wfns ≤ 3 exclusion criteria: * absolute contraindication to surgery, endovascular treatment or anesthesia * patients unable to give informed consent * diameter of the aneurysm ≤ 4 mm but ≥ 11 mm * ruptured aneurysms with wfns 4 or 5

Keywords: intracranial aneurysm cerebral aneurysm brain aneurysm unruptured cerebral aneurysm ruptured cerebral aneurysm web embolization device embolization
study evaluating a novel ibuprofen formulation in the treatment of dental pain

Conditions: Pain

Summary: this study will compare the pain relieving effect of a single-dose of a novel ibuprofen formulation to placebo and two formulations of standard ibuprofen in the treatment of post-surgical dental pain following "wisdom" tooth (third molar) removal.


Eligibility criteria:
inclusion criteria: * normal, healthy males and females 16 to 40 years of age * outpatients who have moderate to severe post-operative pain (confirmed by a visual analog scale-pain severity rating \[vas-psr\] score of at least 50 mm on a 100 mm vas-psr) following surgical extraction of two or more third molars, at least one of which must be a partial or complete bony mandibular impaction * use of only the following pre-operative medication(s)/anesthetic(s): topical benzocaine, a short acting parenteral (local) anesthetic (mepivacaine or lidocaine) with or without vasoconstrictor and/or nitrous oxide exclusion criteria: * pregnancy or breast-feeding * alcohol or substance abuse * any serious medical or psychiatric disorder * history of stomach ulcers, stomach bleed, or other bleeding disorders * use of a prescription or over-the-counter drug with which administration of ibuprofen or any other non-steroidal anti-inflammatory drug, acetaminophen, or hydrocodone is contraindicated (including: opioids, antipsychotics, antianxiety agents, or other central nervous system depressants\[including alcohol\])

Keywords: pain following third molar extraction
impact of patient-prosthesis-mismatch on coronary flow reserve

Conditions: Coronary Artery Disease

Summary: complete normalization of cfr following avr for aortic stenosis was observed only for stentless valves. besides the superior hemodynamic performance this might explain the excellent long term results of this valve design.


Eligibility criteria:
inclusion criteria: aortic valve stenosis exclusion criteria: coronary artery disease

Keywords: coronary artery disease coronary flow reserve heart failure prospective randomised
clinical outcome of coracoclavicular ligament repair using autogenous gracilis tendon in endobutton system.

Conditions: Acromioclavicular Joint Dislocation.

Summary: there are many surgical methods available for the treatment of patients with acromioclavicular dislocations. no single method has yet proven to be superior to the others. the purpose of this study is to evaluate the clinical outcome and complications associated with coracoclavicular ligament repair using autogenous gracilis tendon graft implanted in a single transclavicle transcoracoid bone tunnel. the implantation is performed using an endobutton system that augments the repair with fibrewires. the investigators will prospecitvely follow 30 patients enrolled in the study. the hypthesis is that this near anatomical repair of the coracoclavicular ligaments will result in good clinical outcome and few complications.


Eligibility criteria:
inclusion criteria: * age between 18 and 75 years old. * shoulder trauma within last 2 weeks. * pain from the acromioclavicular joint. exclusion criteria: * chronic or concomitant acromioclavicular joint pathology on injured side. * previous acromioclavicular joint dislocation on contralateral side. * major shoulder pathology on affected side. * mental inability to take part in rehabilitation. * non swedish or english speaking patients.
endometrial changes in breast cancer women with or without hormonal therapies

Conditions: Breast Cancer; Endometrial Cancer

Summary: a history of breast cancer is a risk factor for the development of endometrial pathologies, such as typical and atypical glandular hyperplasia, endometrial polyps, uterine fibroids, endometrial adenocarcinoma and uterine sarcoma, probably due to some common risk factors (eg. obesity, nulliparity). even if ethiopathogenesis for breast cancer and endometrial pathologies is not well established, both genetic factors and hyperestrogenic state may be play a pivotal role for their development. indeed, relative hyperestrogenism is also the main target for the treatment of breast cancer. currently used therapies for this purpose are selective estrogen receptor (er) modulators (serms), such as tamoxifen (tam), and third generation non-steroidal aromatase inhibitors (ais), such as letrozole and anastrozole. tam has both agonist and antagonist properties, depending upon the individual target organ and circulating levels of serum estrogens: on the one hand, it blocks estrogen stimulation in breast tissue; on the other hand, tam shows an er agonist activity in the endometrium that is able to stimulate proliferation and, in some cases, it causes an increased risk of uterine pathologies. women with hormone-dependent breast cancer have to use tam for five to ten years. many reports suggest that the risk of uterine pathologies increases with the time of administration. considering these elements, the primary aim of this study will be to investigate the incidence of endometrial pathologies, especially of endometrial cancer, in different groups of breast cancer women undergoing diagnostic hysteroscopy.


Eligibility criteria:
inclusion criteria: * history of breast cancer treated with surgery (regardless of the adjuvant radio/chemotherapy) exclusion criteria: * incomplete data collection * recurrence of breast cancer * any other concomitant disease * any pharmacological treatment (wash-out: 3 months) other than tamoxifen or aromatase inhibitors * women who switched from a therapy to another one during the study period.

Keywords: tamoxifen aromatase inhibitors breast cancer endometrial cancer endometrial pathologies
the role of routine bacterial culture including tuberculosis during bronchoscopy: a prospective study

Conditions: Tuberculosis

Summary: many centers routinely culture bronchoscopy samples for bacteria and mycobacteria even when infections including tuberculosis (tb) are not strongly suspected. however, the value of this practice has been poorly defined.

many centers routinely culture bronchoscopy samples for bacteria and mycobacteria even when infections including tuberculosis (tb) are not strongly suspected. however, the value of this practice has been poorly defined. unnecessary bronchial cultures of bacteria may lead to over treatment in patients without clinical evidence of infections and may increase the drug resistant strains. in areas with a high prevalence of tb, routine bronchial cultures may detect clinically unsuspected tb in an appreciable proportion of cases. however, in population with a low prevalence of tb, routine culture of bronchial aspirates may incur an unnecessary expanse and may lead to over diagnosis and over treatment of patients with non pathogenic atypical mycobacteria detected by acid-fast bacillus strains.

Eligibility criteria:
inclusion criteria: 1. patients who will undergo a bronchoscopy examination at pulmonary department in meir medical center 2. patients who will sign on informed consent. - exclusion criteria: * 1)age under 18 years

Keywords: tuberculosis, culture, bronchoscopy
clinical trial to study the safety and tolerability of memantin mepha® in sickle cell disease patients

Conditions: Sickle Cell Disease

Summary: symptomatic sickle cell disease is worldwide the most frequent cause for hereditary hemolytic anemia with recurrent pain crisis. hemolysis, vaso- occlusive and pain crises are hallmarks of this disease and are causative for an important socio-economic burden worldwide, especially in africa. aside from allogenic stem cell transplantation, which is rarely available and very expensive, at present there is no curative treatment for patients with sickle cell disease (scd). the current standard of care includes treatment with hydroxycarbamide and symptomatic care such as transfusions, antibiotic/analgesic treatment. this study has the aim to study the safety and tolerability of memantin in patients with sickle cell disease.

during the study participants will be asked if medical occurrences (aes) happened and laboratory analysis (haematology, coagulation, chemistry) and urine samples will be taken. in addition at each visit a physical examination and measurement of vital signs will be performed. in addition the number of hospital days and emergency consultations, the impact on working ability (the number of days with inability to work, changes in iv%), the amount and type of analgesic medication, the amount of rbc transfusions, the number of days that antibiotics prescribed and haematology (at local and external laboratory) and chemistry laboratory parameters will be assessed. for the impact on work and social life a questionnaire of quality of life will be filled out monthly by the patient. at screening and at the end of the study scd specific assessments will be performed, which include cardiologic examination (ecg, echo), abdominal sonography, ophthalmological examination, lung function testing and neuroangiologic examination.

Eligibility criteria:
inclusion criteria: * documented symptomatic sickle cell disease (hbss or hbs/beta thalassemia) * age 18 years or older * able and willing to provide written informed consent and to comply with the study protocol procedures * willing to use two effective methods of contraception during study treatment until 6 months after stop of study treatment. effective contraception methods are considered oral, injectable, implantative contraceptives or intrauterine contraceptive devices combined with the use of condom. exclusion criteria: * history of transfusion during last three months before screening * patients with active bacterial, viral or fungal infection requiring systemic treatment * patients with known infection with human immunodeficiency virus (hiv) of human t cell leukaemia virus 1 (htlv-1) * inadequate renal function: creatinine clearance \< 30ml/min * inadequate liver function: ncictc grade 3 liver function tests (ast, alt \> 5x upper limit of normal (uln)) * history of malignancy * women who are pregnant or breast feeding * previous known mental disorder or known family history of psychiatric diseases * known epileptic disease * the receipt of any investigational product within 30 days prior to this trial