Kornimate/medical-research-clean huggingface dataset:
family functioning and adverse side effects of family-based therapy for anorexia nervosa

Conditions: Anorexia in Adolescence; Anorexia in Children; Family Relations

Summary: the study examines potential adverse side effects on family functioning and parent-child relationships of standard treatment family-based therapy (fbt) for anorexia nervosa (an) in children and youths.

background: family-based treatment (fbt) for anorexia nervosa (an) in children and youth has contributed significantly to the treatment of a disorder that has otherwise had a poor prognosis. focus in fbt is on empowering parents to take full control over their child's nourishment. however, many parents are concerned how fbt might affect the relationship with their child as parents assume a double role of insisting on eating and weight gain, while at the same time providing emotional support, when this distresses the child. moreover, fbt may have a "blind eye" to psychological difficulties with e.g. emotion regulation and interpersonal challenges, and thus inadvertently exacerbating them while focusing narrowly on eating and weight gain. aim: the aim of the study is to quantitatively investigate side-effects of fbt by: 1. assessing average changes as well as variations across families from start of fbt, after 3 months, and at end of fbt in four domains: perceived parental stress level and family function, emotion regulation ability and perceived attachment to parents. 2. qualitatively describe the lived experience of young persons as well as parents going through fbt. 3. based on the results of a) and b) to generate hypotheses on which additions and / or alterations to treatment that may mitigate potential adverse side effects of fbt- treatment. these modifications to fbt will be tested in a future clinical trial. exploratively, we will investigate whether level of family functioning at three months of fbt predicts changes in the four above mentioned domains at end of treatment (eot), thus identify early in treatment the families at risk of adverse side-effects of fbt. methods: family functioning, parental stress level and attachment perception are measured with questionnaires only. emotion regulation is measured with questionnaires and the tangram puzzle task. the qualitative section of the study consists of interviews at end of treatment and will be conducted in a co-operation with the danish patient organization eating disorders and self harm. the project is a sub study to the larger study investigating response to treatment of eating disorders in youth: effectiveness of family-based intervention in a child and adolescent mental health service (camhs) for children and adolescents with eating disorders (vibus).

Eligibility criteria:
inclusion criteria: * diagnosis of f50.0 or f50.1 first time of treatment with family-based treatment living with a minimum of one parent informed consent from young person and parents exclusion criteria: * non danish-speaking
long term outcome in icu treated covid-19: risk factors for 1-year mortality

Conditions: Covid19

Summary: mortality within one year after intensive care unit (icu) admission with coronavirus disease 2019 (covid-19) will be assessed. risk and risk factors for one year mortality in icu patients will be compared to patients admitted to hospital with covid-19 and general population controls. the icu population comprises all swedish icu patients with covid-19 with at lease one year of follow up. the hospital admitted cohort comprises four hospital admitted patients with covid-19 per icu patient, matched on age, legal gender and region. the general population controls are matched to the icu patients in a one to four fashion on age, legal gender and region. icu patients are identified in the swedish intensive care registry. the hospital admitted patients are identified in the national patient registry and the population controls are identified in the population registry. data on socioeconomics and income are provided by the statistics sweden. data on comorbidity, medications and death are provided from the national board of health and welfare.


Eligibility criteria:
inclusion criteria: * admitted to a swedish icu and registered in the swedish intensive care registry with the icd 10 diagnosis u07.1 before 1 july 2020. icu-cohort. or randomly selected from all patients admitted to hospital but not icu with the icd 10 diagnosis u07.1 in the national patient registry, matched on age, legal gender and region (four per icu patient) before 1 july 2020. hospital cohort. or randomly selected from the general population (and not included in the icu or hospital admitted cohorts), matched on age, legal gender and region (four per icu patient) exclusion criteria: * missing a swedish personal identification number

Keywords: long term outcome mortality covid-19 risk factors critical care
lifespan integration after sexual trauma

Conditions: Symptoms of Post Traumatic Stress Disorder (PTSD)

Summary: a new psychological trauma treatment method is tested on a population (n 100) of adult women who have been sexually traumatized at one specific time 0-5 years before they enter the study.

one treatment session is given with the psychological treatment method lifespan integration (li). the main outcome is change on impact of event scale (ies) before and after the treatment. the change is analyzed and compared with the change on impact of event scale (ies) among the people on the waiting list arm. self-rating questionnaires are being used 5+/-3 days before treatment, 20 +/-3 days after treatment, and 6 months +/- 6 weeks after the first measurement.

Eligibility criteria:
inclusion criteria: * sexual trauma 1-5 years before inclusion * understanding swedish, read and spoken exclusion criteria: * psychotic symptoms * drug abuse * neuropsychiatric diagnoses adhd and asperger

Keywords: sexual trauma, lifespan integration
feasibility of a stress reduction intervention study in sickle cell disease

Conditions: Sickle Cell Disease; Stress

Summary: stress is known to trigger acute pain crisis of sickle cell disease (scd). scd is an inherited blood disorder that afflicts about 100,000 people in the united states, and is among the most common lethal genetic diseases in the united states. though worldwide in distribution, in the us it is most commonly found in african americans. its best known complication is severe, recurrent relentless pain, often known as pain crisis. non-drug treatment for scd pain such as cognitive coping interventions have been shown to be effective for reducing scd pain intensity, but they are complicated, multifaceted, and time-consuming. a simple and cost-effective alternative such as guided imagery (gi) could reduce the effect of stress on scd pain. gi is an intervention where patients listen to and view audio-visual recordings while being directed to visualize themselves being immersed in that scene or scenario. there are no published studies on the use of gi as a simple stress coping intervention or tracking stress in a systematic manner as a trigger for scd pain.


Eligibility criteria:
inclusion criteria: * adults 18 years of age or older, * diagnosis of scd, * self-reported pain of at least 3 on a 0-10 scale related to scd, * spoke and read english, and * self-identified as being of african or hispanic descent. exclusion criteria: * legally blind or physically unable to complete procedures.
pre-operative biliary sems rct during neoadjuvant therapy

Conditions: Pancreatic Cancer

Summary: the purpose of this study is to demonstrate non-inferiority of fully covered biliary sems to uncovered biliary sems in biliary drainage for the pre-operative management of biliary obstructive symptoms caused by pancreatic cancer in patients undergoing neoadjuvant therapy.


Eligibility criteria:
inclusion criteria: * age 18 or older * patient indicated for biliary metal stent placement for the treatment of jaundice and/or cholestasis * willing and able to comply with the study procedures and provide written informed consent to participate in the study * suspicion of pancreatic adenocarcinoma * likely indicated for neoadjuvant treatment * distal biliary obstruction consistent with pancreatic cancer * location of distal biliary obstruction such that it would allow the proximal end of a stent to be positioned at least 2 cm from the hilum * endoscopic and surgical treatment to be provided at the same institution exclusion criteria: * benign biliary strictures * malignancy secondary to intraductal papillary mucinous neoplasm * surgically altered anatomy where ercp is not possible * previous biliary drainage using a sems or multiple plastic stents * contraindications for endoscopic techniques * patients who are currently enrolled in another investigational trial that would directly interfere with the current study * pregnancy

Keywords: pancreatic pancreatic cancer preoperative biliary drainage neoadjuvant therapy
physical therapy in the treatment of carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: in the present investigation the pain reduction effects of a physical therapy technique will be compared to those produced by the absence of treatment, in subjects who suffer the signs and symptoms of carpal tunnel syndrome.

the present randomized clinical trial will perform a comparison of the pain reduction effect produced by the application of the median nerve neural mobilization technique (a non pharmaceutical physical therapy treatment), to the pain reduction effect produced by the total absence of treatment in subjects who suffer carpal tunnel syndrome. functionality of the affected upper limb will be evaluated and compared. subjects will be invited to participate and randomly allocated to 2 different groups.

Eligibility criteria:
inclusion criteria: * participants must be medically diagnosed with unilateral carpal tunnel syndrome (with confirmative electrodiagnostic findings). * full understanding of written and spoken spanish (language). * participants must freely consent to participate. * the presence of positive phalen an tinel sings. * the presence of carpal tunnel syndrome signs and symptoms exclusion criteria: * the lack to meet inclusion criterions, the presence of cognitive impairment, kinesiophobia * tumors * cancer * upper limb surgery or trauma * pregnancy * deformities of the (affected) upper limb * recent skin injuries or infections (in the affected upper limb) * autoimmune inflammatory conditions or flu type symptoms. * allergy to gabapentin * participants must not be (during the present investigation) under any type of pain reducing treatment (conservative, homeopathic, invasive or not invasive).

Keywords: pain management physiotherapy manual therapy median nerve neural mobilization neural mobilization
endermotherapy with burn hypertrophic scars

Conditions: Burn Scar

Summary: mechanical massage or endermotherapytm is applied to scar tissue with the intended therapeutic value being the promotion of structural or physiological changes. these proposed changes are meant to induce more pliability, so that skin possesses the strength and elasticity required for normal mobility. the advantage of mechanical massage compared to manual massage is that it provides a standard dosage using rollers and suction valves to mobilize the tissue. however, research documenting and supporting this effect is lacking. the objective of this proposal is to document the effect of 12 weeks of endermotherapy treatment on hypertrophic scar characteristics, including erythema, pigmentation, pliability, and thickness in adult burn survivors and their subjective evaluation of itch, pain and overall scar outcome through a prospective, randomized, controlled, within-patient, single-blinded study.

patients will receive 12 weeks of endermotherapy , 3 times a week.

Eligibility criteria:
inclusion criteria: * females and males, of any race, 14 years or older, * a thermal injury, * at least 3 months post-burn so that the scars will be durable enough to tolerate the proposed forces, * at least 2 scar sites \>2.034 mm thick and within 0.5 mm of each other, and * signed the informed patient consent form exclusion criteria: * subjects who have keloids, * with a diagnosis of psychiatric illness clearly documented in their medical file, * mechanism of injury is an electrical, chemical, or cold injury, * a dermatological conditions in the region of the evaluation site, that may interfere with the study results, * a suspected or known allergy to ultrasound gel, * unable to understand french or english, or * subjects who refuse to give informed consent.
exploration of the biologic basis for underperformance of oral polio and rotavirus vaccines in bangladesh

Conditions: Rotavirus Diarrhea; Vaccine Virus Shedding; Tropical Enteropathy

Summary: oral polio and rotavirus vaccines are significantly less effective in children living in the developing world. tropical enteropathy, which is associated with intestinal inflammation, decreased absorption and increased permeability, may contribute substantially to oral vaccine failure in developing country settings. other possible causes of oral vaccine underperformance include malnutrition, interference with maternal or breastmilk antibodies, changes in gut microbiota, and genetic susceptibility. primary objective: to determine whether tropical enteropathy impairs the efficacy of oral polio and rotavirus vaccines in children in bangladesh. secondary objectives: 1) to determine the impact of an ipv (inactivated polio vaccine) boost on the efficacy of opv (oral polio vaccine) and 2) to determine the efficacy of rotarix oral rotavirus vaccine to prevent rotavirus diarrhea the polio and rotavirus randomized clinical trials are embedded as secondary objectives within the exploratory study of tropical enteropathy. the primary and secondary outcome measures are relevant to the randomized clinical trials.


Eligibility criteria:
inclusion criteria: 1. mother willing to sign informed consent form. 2. healthy infant aged 0 to 7 days old. 3. no obvious congenital abnormalities or birth defects. 4. no abnormal (frequency and consistency) stools since birth. 5. stable household with no plans to leave the area for the next one year. exclusion criteria: 1. parents are not willing to have child vaccinated at the field clinic. 2. parents are not willing to have child's blood drawn. 3. parents are planning to enroll child into another clinical study during the time period of this trial. 4. mother not willing to have blood drawn and breast milk extracted. 5. parents not willing to have field research assistant in home two times per week. 6. history of seizures or other apparent neurologic disorders. 7. infant received any vaccines before start of study, except bacillus calmette-guerin (bcg). 8. infant has any sibling currently or previously enrolled in this study, including a twin.

Keywords: oral vaccines vaccine responsiveness tropical enteropathy
child and adolescent registry for participants with narcolepsy

Conditions: Narcolepsy

Summary: catnap is a patient registry designed to improve the understanding of the natural history of narcolepsy in pediatric patients. descriptive statistics on disease characteristics will be performed. the study has 16 active clinical sites and a virtual site that widens participation to anywhere in the united states. for more information about the study or to access the online patient enrollment system, visit the catnap website: https://catnap.healthie.net/welcome or email catnap@pulseinfoframe.com. the online patient enrollment system, catnap website, can also be found in the references section.


Eligibility criteria:
inclusion criteria: * any child or adolescent with a physician-confirmed diagnosis of narcolepsy * age less than 18 years * willing to participate in the registry and complete the informed consent form * able to participate in english based registry exclusion criteria: * age 18 years or more * fail to complete the informed consent form
management of childhood pancytopenia

Conditions: Pancytopenia

Summary: pancytopenia is an important hematologic problem.it is a decrease in all three cellular elements of peripheral blood leading to aneamia, leucopenia and thrombocytopenia.

pancytopenia usually presents with symptoms of bone marrow failure such as pallor, dysnea, brusing and increased tendency to infections. the incidence of various disorders causing pancytopenia varies according to geographical distribution and genetic mutations. it can result from : * failure of production of hematopoietic progenitors in bone marrow as in aplastic aneamia. * bone marrow infiltration by malignant cells as in acute leukemia. * antibodies mediated bone marrow suppression as in systemic lupus. * ineffective hematopoiesis and dysplasia as in nutrition deficiency. * peripheral sequestration of blood cells in over active reticuloendothelial system as in hypersplenism. pancytopenia is not a disease entity but a triad of findings that may result from primary or secondary bone marrow involvement. bone marrow aspiration and biopsy evaluation along with clinical correlation are important to evaluate the causes of pancytopenia and plan further investigations and treatment. pancytopenia can result from damage to bone marrow evidanced by low reticulocyte count, or increased destruction of the peripheral blood with increased reticulocyte count. bone marrow examination is a simple and safe invasive procedure for evaluating the causes of pancytopenia. the hypoplastic marrow which occurs in 2% of pediatrics acute lymphoblastic leukemia may be misdiagnosed as aplastic aneamia. studies done have shown leukemia to be the second most common cause of pancytopenia in pediatrics, marginally behind aplastic aneamia.

Eligibility criteria:
inclusion criteria: * all childrens and adolescents suffering from pancytopenia attending heamatology unit of pediatric department assiut university hospital will be included. exclusion criteria: * childrens and adolescents suffering from pancytopenia due to malignancy.

Keywords: mcp
cd5024 1% [ivermectin 1%] cream versus metronidazole 0.75% cream in papulopustular rosacea (ppr) study

Conditions: Papulopustular Rosacea

Summary: study objectives: * to compare efficacy and safety of ivermectin 1% cream versus metronidazole 0.75% cream in subjects with papulopustular rosacea after 16-week topical treatment. * and to compare, for subjects initially successfully treated by 16 weeks treatment, ivermectin 1 % cream versus metronidazole 0.75% cream during a 36-week extension period by assessing, the time of first relapse, the relapse rate, and the number of days free of treatment


Eligibility criteria:
inclusion criteria: * subjects with papulopustular rosacea scored 3 (moderate) or 4 (severe) according to the investigator global assessment (iga), * subjects with at least 15 but not more than 70 inflammatory lesions (papules and pustules) on the face. exclusion criteria: * subjects with particular forms of rosacea (rosacea conglobate, rosacea fulminant, isolated rhinophyma, isolated pustulosis of the chin) or other facial dermatoses that may be confounded with papulopustular rosacea, such as peri oral dermatitis, facial keratosis pilar, or seborrheic dermatitis and acne, * subjects with rosacea with more than two nodules on the face.
preoperative assessment for synchronous carcinoma or polyps with magnetic resonance (mr) colonography

Conditions: Obstructing Colorectal Cancer

Summary: the purpose of this study is to diagnose possible synchronous carcinomas and polyps with magnetic resonance (mr) colonography in patients booked for operation because of carcinoma in the descending or sigmoid colon, where a preoperative full colonoscopy is not possible. two days before colonography, patients ingest a 200 ml barium sulfate solution four times a day, which will render fecal masses "invisible" on the following mr colonography. the study is primarily a feasibility study with altered operative strategy as a secondary end-point. gold standard is colonoscopy and operation.


Eligibility criteria:
inclusion criteria: * obstructing colorectal cancer exclusion criteria: * suspicion of ibd * pacemaker * metal in the body * claustrophobia * pregnancy

Keywords: colorectal cancer polyps virtual colonoscopy synchronous carcinoma mr colonography
evaluation study for the programme diane for people with diabetic nephropathy

Conditions: Diabetic Nephropathy

Summary: this study is designated to evaluate the effect of a patients' educational program called diane® for consultation and support people with diabetic kidney disease in an early stage. the aim of the study is to examine if the program is suitable to stop deterioration of kidney function and to maintain or improve glycemic control. the consultation and support program diane® substantially contributes to a better understanding of the affected clients for this complex clinical picture, allows them for specific interventions and creates the rationale for an active therapeutic relationship.

according to statistics diabetes mellitus is considered to be the leading cause for end stage renal disease in germany, approximately 35% of the patients starting on dialysis are affected by diabetes-induced nephropathy. this can be seen in countries all over the world. this situation has been known for years. to date, neither structured intervention methods nor educational programs have been designed for and targeting those affected, which would consequently allow for structured, multifactorial intervention at an early stage of diabetic nephropathy. multifactorial interventions, as published in the steno-2 trial, appear to be highly effective with regard to long-term complications of diabetes. in order to realize this approach for the affected as well as the medical staff caring for patients with diabetes-induced nephropathy we developed diane®, a consultation and support program, which is designed to give detailed information to the affected in order to induce behavioral changes. we were able to show a clinically significant reduction of microalbuminuria within a first monocenter evaluation trial. we wanted to verify this effect by means of a prospective multicenter randomized cohort trial according to gcp-ich guidelines.

Eligibility criteria:
inclusion criteria: * diabetes mellitus * proven diabetic nephropathy by histological/lab findings and/or discretion of nephrologist * ability to understand the german language exclusion criteria: * end stage renal disease and/or dialysis * unable or unwilling to follow the protocol * pregnant women * discretion of nephrologist

Keywords: diabetes mellitus diabetic nephropathy hypertension