Kornimate/medical-research-clean huggingface dataset:
influence of pregnenolone on exposure therapy in obsessive-compulsive disorder

Conditions: Obsessive-compulsive Disorder (OCD)

Summary: characterization of the influence of pregnenolone vs. placebo on subjective distress and autonomic functioning during cognitive-behavioral exposure therapy in patients with obsessive-compulsive disorder.

main out-come parameters: inter-session habituation as per sud (100 mm vas), y-bocs secondary out-come parameter: hf/lf of hrv, salivary epinephrine

Eligibility criteria:
inclusion criteria: -ocd according to dsm-iv criteria. exclusion criteria: * acute suicidality * psychotic disorders, * bipolar disorder * substance dependency * organic brain disorder * pregnancy * lactation * tuberculosis * gastric/duodenal ulcer * diabetes mellitus * acute inflammation * autoimmune disorders * arterial hypertension * therapy with glucocorticoids (up to 4 weeks ago)

Keywords: obsessive-compulsive disorder (ocd) exposure therapy extinction learning pregnenolone
modulation of regional brain activation in schizophrenic patients by pharmacological therapy

Conditions: Schizophrenia

Summary: the study aims to investigate the modulation of regional brain activation in schizophrenic patients by psychopharmacological treatment with either haloperidol, amisulpride or olanzapine. the study will be performed with functional magnetic resonance imaging (fmri) and diffusion tensor imaging (dti).

the current study aims to investigate the following issues: * changes in cognitive activation patterns under therapy with the typical neuroleptic haloperidol as compared to the atypical antipsychotics amisulpride and olanzapine * relationship of these changes in activity to psychopathological, neuropsychological and pharmacotherapeutic variables (e.g. drug plasma level) as well as to certain biological markers (hva, prolactin) * relationship between diffusion anisotropy as an indicator for structural connectivity and cognitive activation patterns under antipsychotic treatment

Eligibility criteria:
inclusion criteria: * in- and outpatients of either sex * able to comply with the protocol * having given their written informed consent of their own free will * total bprs (panss-derived, 1-7 points) minimum 36 points at baseline * schizophrenic or schizophreniform disorder according to dsm-iv criteria (295.10, .30, .40, .90) * definite right-handedness (according to the modified edinburgh handedness inventory) * age 18 - 50 years exclusion criteria: * co-morbid psychiatric axis i disorder (dsm-iv) other than schizophrenia * axis ii disorder according to dsm-iv * present or past history of substance and drug dependence (including alcohol dependence) * participation in a clinical trial within the previous three months * lack of insight * suicidal ideations or aggression against others * consumption of caffeine-containing beverages within 6 hours before assessments * clinically significant findings in ecg or eeg * known intolerance against neuroleptics

Keywords: schizophrenia fmri drug therapy amisulpride
multi-center randomized controlled trial of relay- nyc's nonfatal overdose response program

Conditions: Opioid Overdose

Summary: the new york city (nyc) department of health and mental hygiene (dohmh) has implemented relay, a novel program that engages and intervenes with individuals in the ed following an opioid od and for the next 90 days, with the goal of preventing subsequent od events. the proposed randomized controlled trial will evaluate the impact of relay on preventing subsequent opioid-related adverse events. a total of 350 eligible individuals with nonfatal opioid od presenting to one of four participating eds will be enrolled and randomized to one of two arms: 1) site-directed care (sdc) or 2) relay-peer-delivered od education and treatment linkage, including 90 days of peer navigation. outcomes will be measured for 12 months through interviews and administrative health data.

relay is a novel program that engages and intervenes with individuals in the ed following an opioid od and for the next 90 days, with the goal of preventing subsequent od events. relay is delivered by trained peer navigators, who are dohmh staff with lived substance use experience. relay navigators provide counseling, linkage to services, and od prevention education.

Eligibility criteria:
inclusion criteria: * adults (≥18 years) * english- or spanish-speaking * patient at a participating ed with nonfatal opioid od. * currently residing in nyc exclusion criteria: * unable to provide informed consent * currently incarcerated, currently living in another controlled environment prohibiting research contacts, or currently in police custody * known to be currently pregnant * already participating in the study (patients will only be enrolled into the study once) * already actively engaged in the relay program (within the 90-day program window) * speaks only spanish, at a site and time period when no spanish-speaking ra is available
development of a space exploration assessment for children with spinal muscular atrophy

Conditions: Spinal Muscular Atrophy; Assessment, Self

Summary: the aim of this randomized study is to develop a new motor assessment of space exploration in a 2d environment with upper limbs for children with spinal muscular atrophy 1 and 2 from 3 until 16 years old.

thirty children are included in the prospective randomized study. they are evaluated with the new test, space exploration test (tes), and with the motor function measure (mfm), a gold standard scale. the objective is to compare the results and to demonstrate the complementarity of the two tools.

Eligibility criteria:
inclusion criteria: * children, girls and boys, from 3 to 16 years old, * with spinal motor atrophy 1 and 2 * with social protection exclusion criteria: * cognitive disorders preventing understanding

Keywords: spinal muscular atrophy children motor assessment space exploration upper limbs
pulmonary vein isolation outcomes with fish oils

Conditions: Atrial Fibrillation

Summary: fish oil therapy may decrease the incidence of cardiac arrhythmias. this study will test whether pre-treatment with fish oils before catheter ablation of atrial fibrillation decreases the early post operative occurrence of atrial fibrillation.


Eligibility criteria:
inclusion criteria: * paroxysmal atrial fibrillation (paf). * persistent atrial fibrillation. persistent af is not self-limited. exclusion criteria: * previous pulmonary vein isolation ablation procedure * contraindication for anticoagulation * permanent af * severe valvular pathology * concurrent use of antiarrhythmic medications * inability to give consent * pregnancy

Keywords: atrial fibrillation persistent paroxysmal pulmonary vein isolation omega three fatty acids fish oils
anatomical snuffbox for coronary angiography and interventions

Conditions: Coronary Artery Disease; Vascular Access Complication

Summary: this randomized, single-center, prospective study seeks to compare the conventional radial approach with the recently described distal radial approach (anatomical snuffbox) concerning the patency of the radial artery in patients subjected to coronary angiography or percutaneous coronary intervention.

transradial approach has become the standard approach for coronary angiography (cag) and percutaneous coronary intervention (pci). the current esc/eacts guidelines of myocardial revascularization support using radial approach (ra) rather than femoral approach (fa) if the operators are experts for ra. recently, an alternative transradial access has been suggested at the anatomical snuffbox, with potential additional benefits including a reduction in radial artery occlusion rate (which allows reintervention through the same access site and potential use as a graft), a decrease in other local vascular complications, shorter hemostasis duration, patients' intra and post procedural comfort and shorter recovery time. however, the feasibility of pci via snuffbox approach is still concerned due to the lack of data. therefore, the aim of the study is to compare the two approaches concerning the patency of the radial artery ≥30 days after the intervention with doppler in a randomized way. due to the anastomosis of the distal radial artery with the superficial palmar arch, even in case of total radial artery occlusion within the anatomical snuffbox, the antegrade blood flow may be preserved and, therefore, decreased incidents of radial artery occlusion are expected in the right distal radial artery approach group. the mean diameter of radial artery at the anatomical snuffbox is 2.4 mm, whereas the mean diameter of the radial artery at the forearm is 2.7 mm, and this could potentially contribute to shorter hemostasis duration.

Eligibility criteria:
inclusion criteria: * indication for coronary angiography * informed consent exclusion criteria: * non palpable right radial artery * prior complicated right transradial intervention (radial artery dissection, perforation, occlusion) * prior cabg * stemi * hemodynamic instability * anatomical restrictions (fistula, etc)

Keywords: coronary angiography radial access distal radial access anatomical snuffbox radial artery occlusion
impact of perioperative shedding of the endothelial glycocalyx on the incidence of postoperative acute kidney injury in patients undergoing valvular heart surgery.

Conditions: Valvular Heart Disease

Summary: endothelial glycocalyx, the luminal structure of healthy vasculature, plays critical roles in regulation of inflammatory responses, vascular permeability, blood coagulation. it can be easily damaged by ischemia/reperfusion, hypoxemia, oxidative stress, endotoxin. accordingly, the relationship between the shedding of endothelial glycocalyx and the prognosis of diseases such as diabetes mellitus, atherosclerosis, malignancy has been researched. in cases of cardiac surgery, patients cannot help but be exposed to ischemia/reperfusion, oxidative stress which can damage endothelial glycocalyx. in this research, the investigators would like to discover the impact of perioperative shedding of the endothelial glycocalyx on the incidence of postoperative acute kidney injury in patients undergoing valvular heart surgery.

syndecan-1, heparan sulfate serve as biomarkers of glycocalyx degradation. both biomarkers will be measured 2 times, before the anesthetic induction, and immediately after weaning from cardiopulmonary bypass, during the valvular heart surgery. postoperative acute kidney injury up to postoperative 48 hours, composite morbidity and mortality up to postoperative 30 days will be checked.

Eligibility criteria:
inclusion criteria: - patients undergoing valvular heart surgery (\>20 years old) exclusion criteria: * emergency operation * aorta surgery (graft replacement of total arch or descending thoracic aorta) * minimal invasive surgery * chronic kidney disease (egfr\<30ml/min/1.73m2) / dialysis history * infective endocarditis * malignancy * patients who cannot give informed consent (e.g. illiterate, foreigners) * patients who are already enrolled to another study than can affect the results

Keywords: endothelial glycocalyx acute kidney injury valvular heart disease
post-operative pain after vital pulpotomy in molars with symptomatic pulpitis

Conditions: Pulpitis; Post Operative Pain; Toothache

Summary: the goal of this clinical trial is to investigate post-operative pain (pep) in teeth with symptomatic pulpitis following vital pulpotomy treatments (vpt) with calcium silicate cement (csc). the main questions it aims to answer are: * is the post-operative pain one week after vpt significantly lower than pre-operative pain in permanent molars with symptomatic pulpitis? * how does post-operative pain in these teeth correlate with patient-related factors, such as age, gender, and painkiller intake? participants will: * undergo vital pulpotomy treatment with calcium silicate cement (mta) * provide pain level assessments before vpt, immediately post-treatment, and at 24, 72 hours, and 1 week after treatment. if there is a comparison group: researchers will compare the post-operative pain levels in teeth with symptomatic pulpitis undergoing vpt to assess its effectiveness in reducing pain compared to a control group not undergoing the treatment.

informed consent: volunteers or parents will receive detailed information about protocols, risks, and benefits. informed consent was obtained in writing after providing subject information, and participants could withdraw voluntarily at any time. sample size calculation: sample size calculation, utilizing g. power-3.1.9.2, aimed at relationship analyses with a 95% confidence level, α=0.05, effect size of 0.30, and theoretical power of 0.80, resulting in a minimum sample size of 108. treatment procedure: vital pulpotomy, administered by experienced professionals, involved local anesthesia, rubber dam isolation, caries removal, pulp amputation, hemostasis, application of proroot mta and glass ionomer, and permanent restoration. pain scores, assessed using the modified wong-baker scale, were recorded pre-treatment, at 24 and 72 hours post-procedure, along with inquiries about painkiller usage.

Eligibility criteria:
inclusion criteria: * patients aged between 7 and 70 years * the teeth with diagnosis of irreversible symptomatic pulpitis * permanent first and second molars with vital pulp * pai ≤ 2 with vital pulp. (ørstavik d, kerekes k, \& eriksen hm (1986) the periapical index: a scoring system for radiographic assessment of apical periodontitis dent traumatol 2(1) 20-34, https://doi.org/10.1111/j.1600-9657.1986.tb00119.x.) exclusion criteria: * clinical or radiographic signs of a necrotic pulp * the presence of a sinus, buccal tenderness, pathological mobility or evidence of pathology on a periapical radiograph * teeth with horizontal or vertical root fractures * swelling, acute endodontic, or periodontal abscess * insufficient tooth tissue for a restoration, teeth requiring a post * unable to give informed consent * contraindicated systemic disease * allergies the local anesthesia * antibiotics, biphosphonates, and corticosteroid intake during the 7 days before treatment. * pregnancy or breastfeeding. * patients who needed endodontic treatment on several teeth to avoid a potentially confused pain referral.

Keywords: toothache pulpitis pulpotomy pain postoperative
a vr intervention for promoting prosocial behavior and well-being in youth

Conditions: Youth

Summary: the objective of the present project is to develop a gamified prosocial vr intervention for youth transitioning from secondary to tertiary education, and to test the effectiveness of the gamified prosocial vr intervention for promoting prosocial behavior and well-being.

targeting youth transitioning from secondary to tertiary education, the proposed project will adopt evidence-based intervention programs that use digital technologies to promote prosocial behavior and well-being, thereby supporting better intrapersonal and interpersonal development. the investigators aim to develop a gamified prosocial vr intervention for youth transitioning from secondary to tertiary education and to test its effectiveness through a randomized controlled trial (rct).

Eligibility criteria:
inclusion criteria: * age 15-19 * secondary 6 to college year 1 * can read traditional chinese and understand cantonese exclusion criteria: * history of photosensitive epilepsy * impairment of stereoscopic vision * balance problems
eeg and tms-based biomarkers of als, ms and ftd

Conditions: Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Multiple Sclerosis

Summary: the purpose of this observational study is to improve understanding of the biology of why als, ms and ftd have different effects on different people and facilitate better measurement of the disease in future drug testing. to do this, brain and spinal cord neural network functionality will be measured over time, in addition to profiling of movement and non-movement symptoms, in large groups of patients, as well as in a population-based sample of the healthy population. patterns of dysfunction which relate to patients' diagnosis and coinciding and future symptoms which align with categories of patients with similar prognoses will be investigated and their ability to predict incident patients' symptoms in future will be measured.

the aim of this project is to characterize spatiotemporal patterns of central nervous system dysfunction that correlate with clinical features of als, ms and ftd, to provide non-invasive electrophysiological measurements that can be used in a clinical setting to inform stratification of patients in clinical trials, and to provide data driven diagnostic and prognostic biomarkers and objective clinical trial outcome measures. such dysfunction will be investigated by recording single- and paired-pulse transcranial magnetic stimulation (tms)-associated electromyography (emg) during rest and by recording electroencephalography (eeg) during rest and during cognitive-motor tasks.

Eligibility criteria:
inclusion criteria: * age \>18 years and able to give informed written or verbal (in the presence of two witnesses) consent. * in the case of non-control subjects, a clinical diagnosis of: (i) probable frontotemporal dementia (ftd) including behavioural variant ftd, semantic dementia or primary progressive aphasia) with supportive brain imaging or known ftd causing genetic mutation (ii) multiple sclerosis (ms) according to the mcdonald criteria (polman et al., 2011) or (iii) possible, probable or definite amyotrophic lateral sclerosis (als) according to the el escorial criteria revised (brooks et al. 2000) exclusion criteria: * any diagnosed neurological/muscular disease other than als, ms or ftd * use of neuro- or myo-modulatory medications except riluzole * inability to participate due to disease-related motor symptoms (e.g. inability to sit for the required time or click the mouse to respond) * upper body metallic implants * history of seizure disorders in the participant or immediate family members * anxiety-induced fainting * regular migraine * evidence of significant respiratory insufficiency * sleep time \>2 hours below normal and/or alcohol consumption the night before data collection (in which case, recording session will be rescheduled).

Keywords: eeg tms neurodegeneration network electrophysiology biomarkers cognitive behavioural motor
effectiveness of a digital strategy-based educational skills group for secondary students with organization and academic motivation challenges

Conditions: ADHD

Summary: the purpose of this study is to test the effectiveness of a telehealth-delivered skills training versus active control group for middle and high school students with adhd symptoms. both programs will be delivered digitally (via zoom). investigators will measure student functioning at baseline, post-group, and three-month follow-up. the primary outcomes are adhd symptoms, student grade point average, and attendance as reported in the gradebook. secondary outcomes include parent academic support, autonomy, academic motivation, and organization skills. participant satisfaction with the group will be measured post-group. group attendance and homework completion will also be measured.

120 middle and high school students with elevated adhd symptoms will be recruited for this study, which will take place over the course of the 2021-2022 academic year. the recruitment strategy will be to distribute information about the study opportunity to educator email lists in south florida (see appended email template). educators will be instructed to share information about the study to the parents of students who perceive to experience adhd symptoms in their schools, regardless of special education status or documentation of a disability. students who enroll will be randomly assigned to either receive the stand-g strategy-based group or a peer-support-based, active control group. investigators will blind participants and their parents to which group is the active treatment by informing parents and students that participant will be randomly assigned to one of two groups to help improve school difficulties in youth. the two groups will be of equal duration, both will be led by the same instructors; and will differ only in content (teaching strategies vs. facilitating peer support and problem-solving conversations). students (and their parents) will complete assessments at baseline, post-group, and three months post-group. school records will be obtained for all time points.

Eligibility criteria:
inclusion criteria: students will be required to, * be in the sixth through twelfth grade, * have elevated adhd symptoms * documented impairment according to the snap * documented impairment according to impairment rating scale. * students must be 17.5 or younger at the time of enrollment to ensure that they are still under 18 at the expected completion of the study. parents of eligible students will also participate. exclusion criteria: students may not be, * in a self-contained special education classroom, * possess intellectual disability * be non-english speaking * be older than 18 years old at time of enrollment

Keywords: adhd behavioral intervention telehealth
program for the identification of "actionable" atrial fibrillation in the family practice setting

Conditions: Atrial Fibrillation

Summary: atrial fibrillation (af) is a major risk factor for stroke. the identification and treatment of af is one of the best way to prevent stroke. the problem is that because af may cause minimal symptoms, it often goes undetected before a patient suffers a stroke. also, it is known that as many as half of all patients with known af may not be receiving appropriate anticoagulation for their condition. new technologies are making it possible to improve af detection. subjects in this study will be screened for af using three simple methods: a 30-second pulse check, a hand-held single-lead electrocardiogram (ecg) device and a blood pressure monitor with built-in af screening capabilities. if more patients with af can be detected, more patients will be able to receive guideline-recommended anticoagulant therapy, and more strokes, deaths, disability, and dementia will be prevented.

participants will be screened for af using three simple methods (pulse check, single-lead ecg, blood pressure machine with automated af detection algorithms). subjects screening positive on any test will attend for a 12-lead ecg within 24 h. for all patients with af detected, clinical characteristics and medications will be compared at baseline and 90±14 days later.

Eligibility criteria:
inclusion criteria: 1. age ≥65 years. 2. attending their usual primary care clinic. 3. provide written informed consent. exclusion criteria: 1. patients considered by the investigator to be unsuitable for study follow-up because the patient: 1. is unreliable concerning the follow-up schedule 2. cannot be contacted by telephone 3. has a life expectancy less than the anticipated study duration due to concomitant disease. 2. presence of an implanted pacemaker or defibrillator. 3. inability to have a bp cuff applied. 4. documented significant allergy to ecg electrode adhesive. 5. previously screened as part of this study.

Keywords: atrial fibrillation screening family practice novel screening technologies