Kornimate/medical-research-clean huggingface dataset:
massage impact on sleep in pediatric oncology

Conditions: Cancer; Pediatric Cancer; Chemotherapy Effect; Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia, Pediatric; Hematopoietic Stem Cell Transplantation (HSCT)

Summary: this study aims to determine the impact of massage therapy for pediatric patients receiving intensive chemotherapy or stem cell transplant (sct).

hospitalized pediatric oncology patients report anxiety, pain, disturbed sleep, and excess fatigue. massage is safe, does not interfere with medications, and has been shown in limited studies to have efficacy in improving sleep as well as decreasing fatigue, anxiety and other symptoms in cancer patients and children with various ailments. this project aims to determine if individualized massage therapy for hospitalized pediatric patients receiving intensive chemotherapy or stem cell transplant (sct) is associated with longer duration and improved quality of sleep, more robust circadian rhythms (cars), improved quality of life (qol) and reduced fatigue, anxiety, and pain, as compared to a standard of care group.

Eligibility criteria:
inclusion criteria: 1. diagnosis of cancer, such as acute myeloid leukemia (aml) or relapsed acute lymphoblastic leukemia (rall) or admitted to receive autologous or allogeneic hsct for any indication 2. expected to be an inpatient for at least 21 days 3. aged 12 to 21 years at enrollment. 4. inpatient at children's national or children's hospital of philadelphia (chop). exclusion criteria: 1. cognitive impairment sufficient to preclude completing questionnaires appropriately 2. insufficient knowledge of english or spanish that would prohibit completing the study instruments 3. previous enrollment

Keywords: stem cell transplant (sct) decreased sleep efficiency pediatric cancer diagnosis circadian activity rhythm (car)
prevention and reduction of obesity through active living

Conditions: Obesity

Summary: we will perform a randomized, controlled trial, the primary aim of which is to assess the effectiveness of a behavioral-based physical activity program in the prevention and treatment of obesity and related co-morbid conditions in a primary care setting. we hypothesize that the prevention and/or reduction of obesity and related co-morbidities in patients randomized to an individualized education and behavior counseling group will be greater by comparison to those randomized to a group that receives standard care alone.


Eligibility criteria:
inclusion criteria: * men and women between 25 and 65 years of age. * sedentary lifestyle (planned physical activity for the purpose of health one day per week or less). * abdominally obese (waist circumference greater than 88 and 102 cm for women and men respectively). * weight stable (± 2 kg) for 6 months prior to the beginning of the study. * bmi between 25 and 34.9 kg/m2 (because a lifestyle-based intervention alone for obesity reduction is ideal for persons with a bmi greater less than 35, and, that 94% of overweight and obese canadian adults have a bmi between 25 and 34.9 kg/m2, subjects with a bmi 35 or greater will be excluded). exclusion criteria: * physical impairment which would make the intervention very difficult, or unsafe according to the patient's physician including history of myocardial infarction, stroke, coronary bypass surgery or angioplasty in the last 6 months; peripheral artery disease, unstable angina or ischemia, uncontrolled or insulin dependent diabetes mellitus. * alcohol consumption \> 21 drinks per week. * plans to move from the area. * participating in another research study. * clinically judged to be unsuitable for participation or adherence * inability or unwillingness to provide informed consent. * for women, planned pregnancy in the next 3 years.

Keywords: abdominal obesity, exercise, behaviour modification
surveillance and medical help for hiv-infected intravenous drug users in and out of prison

Conditions: HIV Infections

Summary: it is difficult to detect the intestinal protozoal infections among the hiv-infected persons or travelers diarrhea by using the traditional microscopy or staining methods. the purpose of this study aimed at finding out the appropriate diagnostic methods and the infection rate of the intestinal protozoa, including the entamoeba, cryptosporidium and giardia among the hiv-infected persons by using the antigen detection method and biological method. the investigators also tried to analyze the associated hiv infection status and sexual transmitted diseases (std) including gonorrhea, chlamydial trachomatis, syphilis, genital warts and herpes simplex virus in this study. the study will collect the blood, urine and stool samples from 200 intravenous drug user (idu) with hiv-infected in the prisons, 400 intravenous drug user (idu) without hiv infected and 100 intravenous drug user (idu) with hiv infected receiving methadone maintenance treatment.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of hiv * receiving methadone maintenance treatment * intravenous drug user (idu)

Keywords: hiv-infected person entamoeba cryptosporidium giardia elisa pcr idu gonorrhea chlamydial trachomatis syphilis genital warts herpes simplex virus
clinical comparision of three types of toothbrushes pulsar, crossaction and butler on gingivitis and plaque removal

Conditions: Healthy

Summary: * objective: to compare clinical results of three types of manual tooth brushes on gingivitis and plaque removal efficacy. * material and methods: this study is a single blind randomized trial with crossover design which involved 30 periodontally healthy individuals. at baseline professional plaque removal and oral hygiene instruction are performed for all the students, then they are asked to avoid brushing for 1-2 days. thereafter plaque and gingivitis scores are measured using plaque and gingival indices (pi and gi). then subjects are instructed to use pulsar tooth brush for a two-week period and then, gi and pi indices are assessed again. after passing one-week period for wash out, subjects don't brush for 1-2 days and indices are recorded again. the same procedure are done for cross action, and butler 411 tooth brushes respectively.

this study is a single blind randomized trial with crossover design which involved 30 periodontally healthy individuals. at baseline professional plaque removal and oral hygiene instruction are performed for all the students, then they are asked to avoid brushing for 1-2 days. thereafter plaque and gingivitis scores are measured using plaque and gingival indices (pi and gi). then subjects are instructed to use pulsar tooth brush for a two-week period and then, gi and pi indices are assessed again. after passing one-week period for wash out, subjects don't brush for 1-2 days and indices are recorded again. the same procedure are done for cross action, and butler 411 tooth brushes respectively.

Eligibility criteria:
inclusion criteria: * having at least five teeth in each quadrant; * no partial denture; * no orthodontic banding or retention wires; * no oral lesions or sites with probing pockets depth ≥ 5 mm; * routine use of a manual toothbrush. exclusion criteria: * having any systematic disease which would influence the course of periodontal diseases or the response to the treatment * smoking

Keywords: toothbrushing plaque control gingivitis
neuromodulation to facilitate the effect of ketamine

Conditions: Depression; Chronic Pain; Substance Abuse

Summary: application of external neuromodulation along with ketamine infusion.

apply tms concurrent with ketamine infusion in order to increase the likliehood \& strength of therapeutic benefit

Eligibility criteria:
inclusion criteria: * chronically ill, * treatment-resistant exclusion criteria: * active psychosis

Keywords: thalamocortical dysrhythmia transcranial magnetic stimulation (tms) transcranial electrical stimulation (tes) (n-methyl-d-aspartate) nmda-r antagonist ketamine infusion neuromodulation synergistic effect remission
efficacy of soluble dexamethasone in refractory sciatica

Conditions: Sciatica

Summary: this is a phase 3 prospective randomised double-blind study versus placebo, measuring the efficacy of soluble dexamethasone by echo-guided infiltrations through the sacro-coccygeal hiatus in intractable sciatica

injection of 4ml of dexamethasone phosphate soluble or 4ml of saline solution depending on the randomisation arm

Eligibility criteria:
inclusion criteria: * patients with sciatica of disc origin (radio-clinical concordance on mri or ct) postero-lateral * duration of evolution greater than 3 weeks despite analgesic / ains treatment, and less than 3 months * eva sciatica pain \> 4/10 * oswestry 30 at inclusion * patient aged 18 years and older * patient affiliated to a social security scheme * patient able to understand the protocol and having signed an informed consent * patient with an indication for corticosteroid infiltration in the context of their pathology criteria for non-inclusion * signs or risks of infection, in particular signs of virosis * poor local skin condition * anticoagulation with vka or anti-xa, or haemorrhagic disease * neurological deficit \< 3/5 or signs of cauda equina irritation * tarlov's cyst or low dural sac below week 4 * hypersensitivity to lidocaine, dexamethasone, or any of its excipients * infiltration of the spine within the previous 3 months * patient with bilateral sciatica * patient with sciatica of osteoarthritic origin * patients with chronic respiratory insufficiency * pregnant or breastfeeding women or women refusing effective contraception until m3 * patient deprived of liberty or under legal protection (guardianship or curatorship) * patient under court protection * patients participating in another clinical research protocol involving a drug or medical device * patients unable to follow the protocol, as judged by the investigator * patient refusing to participate in the study * patient with clinically narrowed lumbar canal * patient with polyneuropathy or myelopathy * patient with sequelae of neuropathic pain

Keywords: reluctant sciatica, infiltrations, soluble dexamethasone
investigating clinical trial participation for acne patients

Conditions: Acne

Summary: participation in medical trials usually favors a particular demographic group. but there is limited research available to explain what trial attributes affect the completion of these specific demographic groups. this trial will scrutinize the experiences of patients diagnosed with acne as they take part in a separate medical intervention clinical trial. the focus will be on tracking the rates of completion and withdrawal among these individuals. it will also try to analyze data from the perspective of different demographic groups to check for recurring trends which might yield insights for the sake of future acne patients.


Eligibility criteria:
inclusion criteria: * patient has been diagnosed with acne * patient is able to read, understand and provide written informed consent * patient is a minimum of 18 years or older exclusion criteria: * inability to perform regular electronic reporting * pregnant or lactating women * has significant intercurrent illness, psychiatric disposition or other factors that, in the opinion of the investigator or medical monitor, precludes participation in the study

Keywords: acne
petechiae in children (pic) study: defining a clinical decision rule for the management of fever and non-blanching rashes in children including the role of point of care testing for procalcitonin & neisseria meningitidis dna.

Conditions: Meningitis, Meningococcal; Meningococcal Sepsis; Meningococcal Disease; Meningococcal Infections; Sepsis; Meningitis

Summary: a fever and a non-blanching rash is a relatively common reason for a child to attend an emergency department. a fever and a non-blanching rash can be an early sign of a life-threatening infection known as meningococcal disease. the aim of the pic study is to determine how best to diagnose early meningococcal disease in children. in particular the investigators are interested in researching how quick bedside tests can be used to do this.

a fever an a non-blanching rash is a relatively common presentation the the emergency department. a minority of children with a fever and a non-blanching rash with have a life-threatening infection. currently it is very difficult to determine those children that require urgent treatment from those that have a simple viral illness. the aim of the pic study is to research how to better diagnose those serious infections earlier. data from the study will be used to test the effectiveness of current practice and to identify areas where current practice could be improved.

Eligibility criteria:
inclusion criteria: * fever (recorded or reported) 38 degrees centigrade or higher and a non-blanching rash (at the time of presentation) * features of meningococcal sepsis/meningitis exclusion criteria: * known haematological conditions such as haematological malignancy, idiopathic thrombocytopenic purpura and coagulopathy

Keywords: meningococcal neisseria meningitidis sepsis meningitis procalcitonin pct lamp loop-mediated-isothermal amplification
study of arm and putter movement in golfers with golfer's cramp

Conditions: Occupational; Cramp(s)

Summary: the investigators will investigate golfers with visual evidence of an involuntary movement while putting before and after treatment with a low dose of propranolol.

dystonia affecting athletes has received little research attention and there has been a lack of awareness or interest among both physicians and athletes. task-specific dystonias or occupational cramps affect people while writing, typing, and or playing a musical instrument. our group has previously shown that a subset of golfers who complain of the yips appear to have a task-specific dystonia or golfer's cramp. the yips are characterized by an inability to appropriately complete a golf stroke, most often putting and chipping strokes. most individuals with the yips describe a jerking or shaking movement that interrupts their swing. in many cases the yips are disabling and the golfer, including professional tour players, give up golfing. golfers who have evidence of golfer's cramp will putt a series of putts during which they will be monitored for arm movements and putter movements. they will then be treated with a low dose of propranolol to see if there is a change in these parameters.

Eligibility criteria:
inclusion criteria: * age 18-75 * complaint of golfer's cramp/yips * visual evidence of a movement disorder during putting * able to complete 80 putts during the session exclusion criteria: * contraindication to treatment with propranolol * movement disorder not when putting

Keywords: occupational; cramp(s)
investigation of the effect of massage application on functional status and depression in postpartum mothers

Conditions: Depression, Post-Partum; Massage; Functional Status

Summary: postpartum depression is a condition with high morbidity in mothers and negatively affects all family relationships. it has been observed that depression in the mother at only 2 months of age negatively affects the relationship between the baby and the mother, and that mothers who are depressed and therefore their babies feel more negatively. symptoms usually start to appear from the 2nd or 3rd week after birth. at the same time, most people focus on the physical characteristics of the mother after birth, such as her reproductive system, while ignoring her full functionality. full functionality is a multidimensional concept that includes personal care, baby care, family care, social and professional activities. in the first weeks after discharge, the functional status of the mother may differ as a result of the roles she assumes at home. since the breastfeeding period will begin in new mothers, different treatment methods are preferred instead of drug treatment, one of which is massage therapy. it is thought that massage therapy relaxes the muscles and changes psychological factors. previous studies conducted on postpartum women show that massage has a positive and healing effect on mothers. while previous studies frequently mention its effects on depression, it has also been observed that there are few studies mentioning its functional status. in light of this information, the aim of this study is to investigate the effects of massage on functional status and depression in postpartum women. for this purpose, there will be 2 groups randomized as intervention and control groups. the intervention will be performed as a 45-minute massage once a week for 4 weeks. data will be collected before the first intervention and after the last intervention.


Eligibility criteria:
inclusion criteria: * being within the first 6 months postpartum exclusion criteria: * having a health condition that prevents lying face down (having stitches from a cesarean section, hypertension, etc.) * not being cooperative * all conditions that contraindicate massage
affect of health education on statins medication persistence and clinical prognosis of ischemic stroke patients (help)

Conditions: Ischemic Stroke

Summary: the purpose of this study is to assess the affect of multiple health education interventions for statins medication persistence and clinical prognosis of ischemic stroke patients at 3, 6 and 12 months.

the study is a prospective, multicenter, hospital-based study on secondary prevention for patients with ischemic cerebrovascular diseases between may 2014 and june 2015. physicians from 24 hospitals in beijing underwent a standard secondary prevention training of ischemic cerebrovascular diseases by professional training, instruction manuals, stratification management software. in order to improve the persistence of taking preventive secondary medicine, is patients from these 24 hospitals received healthy education through manuals and digital video disc about health education during hospitalization and acquired secondary preventive knowledge of ischemic cerebrovascular diseases through regular health education messages during 6 months after discharge. patients with is from other 6 hospitals were used as a control, and no such intervention was given to them. telephone follow-up was performed at 3 months, 6 months, and 1 year after the onset of cerebral infarction, during which the use of antiplatelet and statins drugs and recurrence of is were recorded. patients who took antiplatelet drugs or statins at three follow-ups were regarded as persistent antiplatelet drugs or statins taking within one year after the onset of the disease. the main prognostic indicator was the recurrence of is and persistence of statins medication within 1 year, and the main purpose was to explore the impact of persistent statins use on is recurrence.

Eligibility criteria:
inclusion criteria: 1. adult subjects (male or female ≥18 years); 2. acute ischemic stroke occured within 14 days of symptoms onset 3. blood low density lipoprotein (ldl) ≧100mg/dl（2.59mmol/l） 4. patients were prescribed statins at discharge 5. patients signed informed consent 6. patients have a cell phone and have the ability to receive and view messages exclusion criteria: 1. non-cerebrovascular events or hemorrhagic stroke 2. patients have serious heart, liver, kidney dysfunction or coagulation disorders 3. patients have circumstances that may affect the follow-up such as disturbance of consciousness, severe depression or other mental disorders, aphasia 4. modified rankin scale score at discharge ≥3 5. patients with severe vision or vision field impairment which may affect patients to read message in cell phone 6. those who are participating in other clinical trials 7. those who can not guarantee with the completion of 6 month follow-up after enrollment

Keywords: ischemic stroke statins medication persistence outcome
characterization of normal and pathological morphological variations of the temporomandibular joint by real-time magnetic resonance imaging

Conditions: Healthy; Temporomandibular Joint Disorders

Summary: the real time mri rapid flash sequence is particularly interesting for the study of moving organs and joints. this sequence will make it possible to characterize normal and pathological temporomandibular joint movements by mri.


Eligibility criteria:
inclusion criteria: * adult: age ≥ 18 years old; * person with the capacity to understand the instructions given; * person affiliated to a social security scheme or beneficiary of such a scheme; * person having received complete information on the organization of the clinical investigation and having signed informed consent. exclusion criteria: * person with large-scale metallic dental reconstructions; * edentulism more than 5 teeth; * claustrophobia; * contraindication to performing an mri examination * persons referred to in articles 64, 65 and 66 of european regulation 2017/745 on medical devices (rdm) and in l. 1121-5 to l1121-8 of the french public health code
drug use investigation of kaletra tablets (once daily administration) on patients with hiv-infection

Conditions: Human Immunodeficiency Virus Infection

Summary: this study of kaletra (lopinavir (lpv)/ritonavir (rtv)) tablets will be conducted to clarify the following with regard to treatment with this drug: 1. incidence and conditions of occurrence of adverse reactions in the clinical setting 2. factors that may affect the safety and effectiveness of kaletra (qd)


Eligibility criteria:
inclusion criteria: - participants who were receiving kaletra or who started kaletra therapy during the registration period. exclusion criteria: * participants with a history of hypersensitivity to any ingredient of this drug. * participants who are undergoing treatment with any of the following drugs: pimozide, ergotamine tartrate, dihydroergotamine mesilate, ergometrine maleate, methylergometrine maleate, midazolam, triazolam, vardenafil hydrochloride hydrate, sildenafil citrate (revatio), tadalafil (adcirca), blonanserin, azelnidipine, rivaroxaban, voriconazole.

Keywords: kaletra, lopinavir (lpv)/ritonavir (rtv), human immunodeficiency virus (hiv) infection