Kornimate/medical-research-clean huggingface dataset:
vancomycin and daptomycin plus cefazolin for preoperative vascular surgery prophylaxis

Conditions: MRSA Infections

Summary: this study prospectively selects the patients to examine the effectiveness of the investigators' current standard of prophylaxis prior to vascular surgery and to compare the effectiveness of vancomycin and daptomycin plus cefazolin in reducing infections in vascular surgical patients.

according to medqic.org (site for the surgical care improvement project) the current recommended drug of choice for prophylaxis prior to vascular surgery is cefazolin (ancef). the exception would be to allow the use of vancomycin as an acceptable antibiotic for patients undergoing cardiac, vascular or orthopedic surgery due to the increasing risk of methicillin-resistantstaphylococcus aureus (mrsa). the significance of the study is to demonstrate that mrsa coverage is needed in vascular surgery with prosthetic graft placement in areas of the body that is at high risk for infection. by decreasing post surgical site and prosthetic infections, we could significantly reduce vascular surgery mortality and morbidity. cost and amputation rates we feel could also be reduced. patients will be randomized in three groups such as cefazolin,vancomycin and cefazolin, daptomycin and cefazolin and then patients will be monitored per usual post-operative course (30 days and 90 days follow-up) with wound and incision evaluation. outcome measures include hospital length of stay, the presence of a graft infection, skin infection at incision site, vascular procedure failure secondary to infection, cost, thirty day readmits, amputation, and mortality.

Eligibility criteria:
inclusion criteria: * patients greater than 18 years of age undergoing vascular surgery including carotid procedures and a vascular access procedure (fistula or graft). exclusion criteria: * patients with an allergy to daptomycin or vancomycin. * patients with chronic wounds. * prior colonization of mrsa. * increased mrsa rate facility wide. * continuous inpatient stay \>27 hrs prior to surgical procedure. * patients with active infection requiring antibiotics preoperatively. * patients with a history of mrsa colonization or infection, hiv, admission for \>3 months in an acute care center or long-term care center, penicillin allergy or penicillin allergy and on dialysis. * dialysis patients.

Keywords: vascular surgery
haloperidol vs. valproate in agitation

Conditions: Psychomotor Agitation

Summary: the aim of this study is to compare the efficacy of haloperidol and valproate in management of people with agitation in emergency department


Eligibility criteria:
inclusion criteria: * clinical diagnosis of psychomotor agitation * aged 18 to 65 years exclusion criteria: * pregnant patients * severe liver disease * history of drug (haloperidol/valproate) allergy * readily amendable causes for the agitation (hypoxemia or hypoglycemia) * hypotension (systolic blood pressure (sbp) ≤ 90 mm hg) * known history of liver disease or uncontrolled diabetes * noticeable or suspected head trauma * previous history of neuroleptic malignant syndrome * receiving psychotropic medication, neuroleptic agents or cholinesterase inhibitors at the time of enrollment
biopsy protocol of upper gastrointestinal subepithelial tumors:diagnostic accuracy of eus-fnb versus unroofing biopsy

Conditions: Upper Gastrointestinal Subepithelial Tumors

Summary: to increase the diagnostic accuracy of subepithelial tumors, larger tissue samples are required. it is difficult to obtain adequate tissue samples. there were several biopsy methods to obtain tissue samples. pathological examination would include mitosis counts, particularly in hypoechoic subepithelial tumors located in the 4th layer of the gastric wall, where differentiation between leiomyoma of benign nature and gastrointestinal stromal tumor (gist) of malignant potential is essential. so we hypothesize that unroofing biopsy is an more appropriate method than eus-fnb(endoscopic ultrasonography guided fine needle biopsy). we will compare diagnostic accuracy and complications between eus-fnb \& unroofing biopsy.


Eligibility criteria:
inclusion criteria: * older than 19 years old and younger than 80 years old * suspected upper gastrointestinal subepithelial tumors(≥15mm, ≤35mm) that were originated from muscularis propria layer on endoscopic ultrasonography(eus) exclusion criteria: * patient who had bleeding tendency * any previous surgery on esophagus, stomach or duodenum * patients who can not be underwent sedated endoscopy * gastrointestinal subepithelial tumor that was not origianted from muscularis propria layer on eus * constrast related allergic disease

Keywords: stomach neoplasm biopsy
study protocol for a smartphone application-based intervention for subthreshold depression

Conditions: Subthreshold Depression

Summary: the investigators plan to conduct a randomized controlled trial to examine whether a smartphone-based intervention improves subthreshold depression symptoms compared to no intervention. the purpose of this pilot randomized controlled trial is to investigate the feasibility of the final randomized controlled trial.


Eligibility criteria:
inclusion criteria: * 18 years and older * males and females * center for epidemiologic studies depression scale score ≥16 * written informed consent prior to participation * owns a smartphone with the ios® operating system exclusion criteria: * lifetime history of psychiatric disorders * currently receiving treatment for a mental health problem from a mental health professional * experience of a major depressive episode in the 2 weeks prior to the study, as ascertained using the mini-international neuropsychiatric interview * vision or hearing deficits that negatively impact everyday life
theory-based training to promote breast cancer screening

Conditions: Breast Cancer; Breast Cancer Female

Summary: background: breast cancer worries are important determinants in relation to behavior favoring breast cancer screening. objective: to determine the effect of theory-based training to promote breast cancer screening among women with high and low levels of breast cancer worries. design and setting: randomized controlled trial, conducted in two family health centers. methods: in total, 285 women were recruited. women with low levels of breast cancer worries were included in the first intervention group (112 women) and the first control group (112 women), while women with high levels of breast cancer worries were included in the second intervention group (37 women) and the second control group (43 women). theory-based training to promote breast cancer screening was given to intervention groups. the women's willingness to undergo breast cancer screening and breast cancer worry scores were evaluated at 1, 3 and 6 months.

breast cancer is the most frequent type of cancer and the most common cause of cancer death among gynecological cancers. one in every four women with cancer in the world has breast cancer. the international cancer agency reported that there were around 2,088,849 new cases and 626,679 deaths due to breast cancer worldwide in 2018. the incidence of breast cancer is higher in developed countries than in developing countries, but the numbers of deaths due to breast cancer are lower in developed countries than in developing countries. it is known that breast self-examination, clinical breast examination and mammography play an important role in making an early diagnosis of breast cancer. the uptake rate for mammography performed on a regular basis is low because this is an expensive method, considering that not all individuals have health insurance and public funding is inadequate, especially in developing countries. hence, breast self-examination (which has no cost) and clinical breast examination (which only has low cost) remain important diagnostic methods. moreover, during clinical breast examination, healthcare professionals have the opportunity to advise on breast cancer, risk factors, prevention methods and screening methods.

Eligibility criteria:
inclusion criteria: * the participants included did not have any diagnosis of breast cancer, had not been performing breast self-examination regularly (every month), had not previously had a mammogram, had not previously had a clinical breast examination, were not pregnant or breastfeeding and were literate. exclusion criteria: * missing data collection forms.

Keywords: mammography breast self-examination early diagnosis
adding l-carnitine to clomiphene citrate for induction of ovulation in women with polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome

Summary: polycystic ovary syndrome is one of the most common endocrine disorders, affecting about 6-10% of women in their reproductive age. anovulation and hyperandrogenism are often present together with hyperinsulinaemia and insulin resistance


Eligibility criteria:
inclusion criteria: * primary or secondary infertility. * normal hysterosalpingo-graphy * normal semen analysis of the husband. exclusion criteria: * patient's refusal. * male factors of infertility and/or abnormal hysterosalpingo-graphy * hyperprolactinemia (prolactin ≥ 22 ng/dl). * fsh on day 3 \> 15 miu/ml. * gross ovarian pathology diagnosed by ultrasound.
anterolateral versus posterolateral approach to the fractured hip arthroplasty

Conditions: Femoral Neck Fracture

Summary: the purpose of this study is to determine whether the anterolateral in comparison to posterolateral approach to the hip arthroplasty gives an equal or better clinical results.

the purpose of this study is to compare the anterolateral- to posterolateral approaches in patients suffering a displaced femoral neck fracture operated with an hip arthroplasty. our hypothesis is that the anterolateral approach gives equal or better clinical function, health related quality of life and less complication and reoperations.

Eligibility criteria:
inclusion criteria: * age \> 65 years * displaced femoral neck fracture exclusion criteria: * pathologic fracture * not swedish speaker * not living in västernorrlands county

Keywords: femoral neck fracture arthroplasty surgical approach anterolateral posterolateral
a dose-volume study of a treatment for elevated iop due to open-angle glaucoma or ocular hypertension

Conditions: Open-Angle Glaucoma; Ocular Hypertension

Summary: the purpose of this study was to assess the effects of total volume and total dose on the safety and intraocular pressure-lowering efficacy of anecortave acetate suspension (3 mg and 48 mg) in 0.5 ml and 0.8 ml volumes when administered by anterior juxtascleral depot (ajd) for the treatment of elevated intraocular pressure (iop) in patients with open-angle glaucoma or ocular hypertension.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of open-angle glaucoma or ocular hypertension for at least 6 months; * other protocol-defined inclusion criteria may apply. exclusion criteria: * prior angle surgery in the study eye, severe visual field loss in either eye; * other protocol-defined exclusion criteria may apply.

Keywords: open-angle glaucoma intraocular pressure anecortave acetate
pharmacokinetic study on raltegravir and lamotrigine

Conditions: HIV Infection

Summary: the purpose of this study is to determine whether interactions between raltegravir and lamotrigine take place and to study the safety of the combination raltegravir/lamotrigine before used in hiv patients.

lamotrigine is an anticonvulsive drug that is used both for the treatment of hiv-associated neuropathic pain and the treatment of epilepsy in hiv-infected individuals. lamotrigine is metabolized via glucuronidation. raltegravir is a newly developed integrase inhibitor that is also metabolized via glucuronidation. since both agents are metabolized via glucuronidation, there is a possibility of competition for glucuronidation, leading to drug-drug interactions between raltegravir and lamotrigine. this primary objective of this study is to determine the effect of raltegravir on the pharmacokinetics of single dose lamotrigine (by intrasubject comparison). a secondary objective is to determine the effect of single dose lamotrigine on the pharmacokinetics of raltegravir when compared to historical controls. another secondary objective is to evaluate the safety of combined use of single dose lamotrigine and raltegravir.

Eligibility criteria:
inclusion criteria: * between 18 and 55 years of age * subject does not smoke more than 10 cigarettes, 2 cigars or 2 pipes per day * subject has a quetelet index of 18 to 30 kg/m2 * subject is able and willing to sign informed consent * subject is in good age-appropriate health condition * subject has a normal blood pressure and pulse rate exclusion criteria: * history of sensitivity/idiosyncrasy to medicinal products or excipients * positive hiv test * positive hepatitis b or c test * therapy with any drug (2 weeks preceding dosing) except for paracetamol * relevant history or presence of pulmonary disorders, cardiovascular * history of or current abuse of drugs, alcohol or solvents * inability to understand the nature and extent of the trial and procedures * participation in a drug trial within 60 days prior to the first dose * donation of blood within 60 days prior to the first dose * febrile illness within 3 days before the first dose

Keywords: interactions neuropathic pain pharmacokinetics
long-term functional outcome of children with inflammatory bowel disease

Conditions: Inflammatory Bowel Disease

Summary: inflammatory bowel diseases (ibd) are group of immune system disorders characterized by a chronic course with remission and relapses. canada is one of the countries with the highest prevalence and incidence rates of ibd with 25% of patients present in children and adolescents. as with any chronic illness, ibd diagnosed early in life has a significant impact on the physical, emotional and social development of those affected. consequently, it is logical to speculate that patients with ibd may not do as well in education levels or employment status attained compared to their peers without ibd. if this were the case, then interventions could begin in childhood to better prepare patients with ibd for the challenges of living with a chronic disease. alternatively, if it is shown that they reach comparable social or employment milestones as adults compared to unaffected peers then this would be enormously reassuring to children and their parents. properly designed studies to help in defining more appropriate interventions to these patients are needed. the proposed study includes circulating a survey to evaluate the functioning level of adult patients with ibd who were diagnosed during their childhood. the participants will be asked a series of questions regarding their highest level of educational achievement, the nature of their current employment, and their current marital status. the question format will parallel that of the canadian community health survey from which data from an age matched healthy adult manitobans will be extracted and used as another control group. responses will be analysed for any possible differences between these groups.


Eligibility criteria:
inclusion criteria: * adult patients who were initially diagnosed with ibd in childhood or adolescence (diagnosis was made \< age of 18 years) and who were followed by the section of pediatric gastroenterology at the winnipeg children's hospital from 1974 - 2009. exclusion criteria: * patients in whom the diagnosis of ibd was not fully established following the current north american society of pediatric gastroenterology, hepatology and nutrition (naspghan) guidelines for diagnosing ibd i.e. had clinical, radiologic and endoscopic evidence of ibd (2). * control participants with other chronic debilitating diseases (e.g. malignancy, rheumatoid arthritis, multiple sclerosis, etc..) that may affect quality of life and functional outcome

Keywords: ibd crohn colitis function
orofacial evaluation in women with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: rheumatoid arthritis (ra) can affect any synovial joint. unlike the hand, ever so valued in the physical examination of patients with ra, the joints in the area of the jaw and neck may also be affected in this disease and have their involvement usually underdiagnosed. there are few studies evaluating the incidence of orofacial alteration in the examination as well as the correlation between bite force (bf) and clinical and functional parameters in these patients. the aim of our study was to chacacterize the orofacial alterations in ra patients, correlate the results of the orofacial evaluation with clinical and disease activity parameters, and correlate the bite force with the hand strenght.


Eligibility criteria:
inclusion criteria: ra group: * rheumatoid arthritis (american college of rheumatology) control group: * healthy exclusion criteria: * edentate be total, have been subjected to surgical procedure in the last six months in the region of the hands or oral maxillo facial

Keywords: rheumatoid arthritis bite force grip strenght oral health quality of life
foot self-care in older adults

Conditions: Foot

Summary: this pilot study will make a preliminary evaluation of the efficacy of 2 feet 4 life, a foot care self-management program, on foot care knowledge, foot care self-efficacy, foot care behaviors, and foot pain in community dwelling older adults without diabetes mellitus.

one in three older adults have foot problems such as bunions, corns, calluses, foot pain, or nail disorders, but those problems are often ignored or overlooked until they threaten mobility or quality of life. with proper self-management, skin and nail problems can be addressed before they become severe; however, older adults without diabetes are not routinely informed of self-management techniques unless they consult a specialist. targeting a foot care self-management program to community-dwelling older adults without diabetes may not only enhance foot function and preserve independence but also reach older adults with limited healthcare access. study participants will be 24 nondiabetic older adults recruited from two midwestern community senior centers. one community center will be randomized to receive the intervention, 2 feet 4 life, the other will be a true control group receiving no intervention. the 2 feet 4 life foot care self-management program is based on social cognitive theory and will be delivered in four weekly, one-hour group sessions. the program includes self-management teaching, interactive lecture, and group activities, including instruction, demonstration, and practice of routine foot care. in addition to usual lecture and handouts, 2 feet 4 life will rely on group interaction, practice opportunities, and the provision of foot care supplies so participants can perform foot care at home. program topics include appropriate foot hygiene and footwear, identification and treatment of common foot problems, demonstration of proper foot care with opportunities for practice and instructor feedback, and guidance in obtaining appropriate footwear. outcome measures will be assessed pre-intervention, immediately post-intervention, three months post-intervention, and six months post-intervention. this will be the first study to test a nurse run, community-based, foot care self-management program for non-diabetic older adults.

Eligibility criteria:
inclusion criteria: * 65 years of age or older * legally competent to sign informed consent * willing to participate in the study exclusion criteria: * self-reports of diabetes * non-traumatic amputation * legal blindness. * demonstrated inability to see and remove dot stickers on the feet * active ingrown toenails * absent pedal pulses * poor sensation as defined by the inability to feel more than 3 of 10 foot sites touched with a microfilament * regular visits to a healthcare professional for foot care * score of \<2 on the mental status screener.

Keywords: foot care older adults senior center self-management self-care
the preoperative predictors of optimal cytoreductive surgery in women with advanced ovarian cancer

Conditions: Ovarian Cancer

Summary: 44 patients were enrolled in this study as they had malignant epithelial ovarian tumor.pre-operative staging was assessed by ct scan based on figo classification and compared to the standard laparotomy surgical staging. maximal surgical effort for optimum cytoreduction was achieved and the risk factors for sub-optimal cytoreduction were studied

each patient was subjected to comprehensive medical history taking and careful clinical examination, laboratory investigations (ca-125) and imaging (abdomino-pelvic ct scan). patients with suspected bowel involvement were subjected for colonoscopy. pre-operative abdomino-pelvic ct scans: preoperative ct scans were performed with a high-speed scanner after the oral and intravenous administration of contrast medium. the hard copy images were reviewed by consultant radiologists for assessment of the findings suggestive of malignant adnexal mass which are bilateral lesions, thick septa, enhancing solid components, ascites, and peritoneal deposits . pre-operative staging of cancer ovary was assessed by ct scan based on figo classification: 1. stage ii: tumor involving ovaries with pelvic extension +/- ascites. 2. stage iii: tumor involving ovaries with peritoneal implant outside pelvis +/- ascites. 3. stage iv: tumor involving ovaries with parenchymal liver metastasis and/or pleural effusion. surgical treatment: all patients underwent standard longitudinal laparotomy, intensive surgical staging and maximal surgical effort for optimum cytoreduction which was included all of the following (total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic-omentectomy, appendectomy, surgical removal of all tumor masses, intestinal resections if required).achievement of no gross residual disease has been attempted in all cases. finally, patients were divided into two groups: * suboptimal cytoreduction group with any gross tumor residue. * optimal cytoreduction group without any gross tumor residue. surgical risk factors for optimum cytoreduction: * parenchymal liver involvement. * omental involvement. * bowel involvement. * para aortic lymph node involvement. * peritoneal carcinomatosis: it is defined as disease \> 4 mm involving 2 or more of the following areas; lateral colic gutters, anterior abdominal wall, diaphragm, and pelvic peritoneal reflections. * pelvic sidewall invasion: it is defined as presence of one or more of the following; tumor fixed to the pelvic bony wall, encasement of iliac vessels, and hydroureter.

Eligibility criteria:
inclusion criteria: * malignant epithelial ovarian tumor (eoc) figo stage ii, iii, and iv. exclusion criteria: * patients with previous abdominal or pelvic major surgery, synchronous abdominal or pelvic pathology or medically unfit for surgery

Keywords: epithelial ovarian cancer optimum cytoreduction