Kornimate/medical-research-clean huggingface dataset:
the effect of dexmedetomidine during opioid free anesthesia on postoperative recovery after gastrectomy

Conditions: Gastric Cancer

Summary: "want to know the effect of dexmedetomidine during opioid free anesthesia on postoperative recovery after gastrectomy. patients undergoing open gastrectomy are divided into dexmedetomidine group and control(remifentanil) group, administered during surgery, and compared with the speed of postoperative intestinal function recovery. based on our institution's previous record, the average recovery time was 6 ± 1.4 days. given that it is clinically significant to reduce recovery time by 20%, alpha 0.05 and power 80% require 31 samples per group, and assuming a 10% dropout rate, the total number of samples needed is 68.subjects are patients aged 19 to 75 who are subject to open gastretomy planned by a gastric cancer. the exclusion criteria include american society of anesthesiology grade 3 or higher, patients who have previously been treated for cancer, patients with cancer other than the stomach, patients with drug allergies, weight less than 60kg, bmi \> 30 kg/m2, patients who are unable to communicate and are unable to read consent (e.g., illiteracy, foreigners, etc.). the research method is a randomized double-blind controlled study, and the assignment of both drugs is unknown and is used to maintain anesthesia in the form of continuous injection during surgery. primary outcome is the recovery period satisfying the following. 1)intestinal gas passage 2) tolerance of soft bland diet (sbd) for 24 hr. 3) safe ambulation without assistance 4) no requirement iv analgesics after discontinuation of pca (vas \<4). 5) no abnormal physical signs or laboratory test. the secondary outcomes are maximum vas, post-operative hospital stay, complications and readmission rate at 3 months f/u time, post-operative period analgesic requirement, incidence of opioid related side effect.


Eligibility criteria:
inclusion criteria: -patients undergoing open gastrectomy for gastric cancer exclusion criteria: * american society of anesthesiology grade 3 or higher * history of chemotherapy * diagosis of cancer in other organs * history of drug allergy * weight less than 60kg * bmi over 30 kg/m2 patient * cognitive impairment * gait disturbance
early palliative care on quality of life of advanced cancer patients

Conditions: Non-small Cell Lung Cancer; Gastric Cancer; Pancreatic Cancer; Biliary Tract Cancer

Summary: this study compares two types of care - standard oncology care (soc) and soc with early palliative care (epc) (started within 8 weeks after diagnosis of advanced disease) to see which is better for improving the quality of life of patients with advanced lung, pancreas, gastric and biliary tract cancer. the study will use fact-g questionnaire to measure patients' quality of life.

the patients will complete a baseline fact-g questionnaire and then will be randomized to a study group. subjects who are randomized to standard oncology care (soc) will follow up with their treating oncologist. they will consult with the palliative care team at their request or at the request of the treating oncologist or of the family. they will complete fact-g questionnaire at 12 weeks after enrollment. subjects who are randomized to the soc with early palliative care (epc) will meet with a palliative care team (basically composed by a palliative care physician and a palliative care specialized nurse) at their next medical oncology or infusion visit. they will meet with the palliative care team at least every three weeks. they will complete fact-g questionnaire at 12 weeks after enrollment.

Eligibility criteria:
inclusion criteria: * pathologically confirmed metastatic lung (nsclc), pancreatic, gastric and biliary tract cancer, diagnosed within the previous 8 weeks; an eastern cooperative oncology group (ecog) performance status (ps) of 0, 1, or 2; age ± 18 years; metastatic or locally advanced disease (but not susceptible of loco-regional treatments); eligibility to first-line chemotherapy ± biological agents; life expectancy more than three months; written informed consent provided; fact-g questionnaire filled in at enrollment, before the randomization. exclusion criteria: * patients already receiving care from the pc service or pretreated with chemotherapy ± biological

Keywords: early palliative care simultaneous care chemotherapy quality of life
epidemiological study of osteoporosis in the elderly population of shandong province

Conditions: Osteoporosis; Osteoporosis (Senile)

Summary: at present, there is little epidemiological information on osteoporosis in the elderly population of shandong province, especially the lack of systematic research on the role of bone metabolism and biochemical indicators in the diagnosis and prognosis of osteoporosis in the elderly population of shandong province. the group intends to conduct a study on the epidemiological characteristics of osteoporosis patients and the significance of bone metabolism biochemical indexes in the diagnosis and prognosis of osteoporosis in elderly people in shandong province, which includes 1) assessing the prevalence of osteoporosis and the risk factors associated with osteoporosis in the community population, and 2) exploring the role of bone metabolism biochemical indexes in the diagnosis and prognosis of osteoporosis in the hospitalised population. expected outcomes include the establishment of a database of community and inpatient populations in shandong province, publication of research papers, and participation in academic conferences at home and abroad. the database will collect and organise data on osteoporosis in the community and inpatient osteoporosis in shandong province, and provide support for subsequent data analysis and research.


Eligibility criteria:
inclusion criteria: * residents ≥65 years of age who had lived in the area for more than 6 months in the past 1 year exclusion criteria: * people with cognitive impairment or mental illness

Keywords: osteoporosis epidemiology elderly biochemical indexes of bone metabolism
maternal serum level of acth as a predictive marker of preterm labor in patients with threatened preterm labor

Conditions: Threatened Preterm Labor

Summary: the aim of this study is use of acth as a predictive marker in patients of threatened preterm labor .

this is a cross sectional study that will include 261 pregnant women aged between 17 and 35 years with singleton pregnancies between 28 and 36 completed weeks of gestation that had been diagnosed with threatened preterm labor and consented to participate in this study. this study will be conducted at ain shams university maternity hospital after approval of the research and ethics committee. the investigators include all patients which have these following criteria (singleton pregnancy, age between 17 - 35 years, gestational age between 28 and 36 weeks and diagnosis of threatened preterm labor is based on the american college of obstetricians and gynaecologists guidelines (acog, 2003): presence of uterine contractions (at least 4 in 20 minutes or 8 in 60 minutes), cervical dilation \> 1 and \< 4 cm, and/or cervical effacement ≥ 80%. the investigators exclude any patient which has any of the following criteria (preterm rupture of membranes, any uterine anomalies or cervical incompetence, chronic illness such as chronic hypertension or kidney disease, diabetes mellitus, abruptio placenta, preeclampsia and hellp syndrome, fetal anomalies, iugr, smoking or clinical signs of intrauterine infection). blood sample was collected from each patient for measurement of acth level. according to local protocol in ain shams university maternity hospital all women will receive a fixed regimen of tocolysis in the form of nifedipine (epilat) 10 mg orally every 15 minutes for the first hour or until cessation of uterine contractions. then, 60 - 160 mg/day (1-2 tablets 3 times daily) of slowly releasing nifedipine (epilat retard 20 mg tablet) may be given depending on uterine activity. the patients will also receive 6 mg dexamethasone every 12 hours for 4 doses. all women will be followed up till delivery. after delivery, the investigators divide the patients into 2 groups (full term delivery \& preterm delivery) and we compare between these 2 groups by level of hormone.

Eligibility criteria:
inclusion criteria: * singleton pregnancy. * age between 17 - 35 years. * gestational age between 28 and 36 weeks. * diagnosis of threatened preterm labor is based on the american college of obstetricians and gynaecologists guidelines (acog, 2003): presence of uterine contractions (at least 4 in 20 minutes or 8 in 60 minutes), cervical dilation \> 1 and \< 4 cm, and/or cervical effacement ≥ 80%. exclusion criteria: * preterm rupture of membranes. * any uterine anomalies or cervical incompetence. * chronic illness such as chronic hypertension or kidney disease. * diabetes mellitus. * abruptio placenta. * preeclampsia and hellp syndrome. * fetal anomalies. * iugr. * smoking. * clinical signs of intrauterine infection eg (uterine tenderness, foul vaginal discharge, maternal pyrexia ≥ 38°c and/or maternal leucocytosis).

Keywords: threatened preterm labor acth ptl
an adaptive treatment strategy for adolescent depression-continuation

Conditions: Adolescent Depression

Summary: aim 1: assess the feasibility and acceptability of the personalized continuation treatment strategy. aim 2: estimate variances of primary and secondary outcomes with the continuation treatment. aim 3: conduct exploratory hypothesis-generating analyses to inform further development of the personalized continuation treatment strategy to be tested in a subsequent r01 proposal.

male and female adolescents (ages 12-18) will be eligible for the study if they completed acute phase treatment and showed at least a partial response to treatment (cgi-i of minimally improved or better (cgi-i \< 3)). adolescents will enter continuation treatment having either received 12 sessions of ipt-a, 16 sessions of ipt-a, or 12 sessions of ipt-a plus fluoxetine.this is a continuation of the study "an adaptive treatment strategy for adolescent depression (ptad)" nct01802437

Eligibility criteria:
inclusion criteria: * adolescents and parents must be english-speaking * completed acute phase treatment (nct01802437) and showed at least a partial response to treatment (cgi-i of minimally improved or better (cgi-i \< 3)). exclusion criteria: - did not completed acute phase treatment (nct01802437) or did not show at least a partial response to treatment (cgi-i of minimally improved or better (cgi-i \< 3)) to acute phase treatment.
effectiveness of balance training in chronic low back pain patients

Conditions: Chronic Low Back Pain

Summary: balance problems are addressed in low back pain patients. dearth of literature available to prove core strengthening or any form of back exercises improving functional outcomes or balance in chronic back pain patients. no studies focus on balance training in improving balance of low back pain patients. the authors are conducting a randomised trial comparing balance exercises and routine back exercise program in improving pain, functional outcomes and balance of the patients

background: balance deficits are common in low back pain. current literature fail to prove the effectiveness of routine back exercises in improving balance of back pain patients. no study has concentrated on balance training in back pain patients. objective: compare balance exercises and routine back exercises in improving balance and other functional outcomes. procedure: back pain patients attending physiotherapy department of tertiary care teaching hospitals will be recruited voluntarily. randomised to either balance and routine program based on simple lottery method. balance training comprises of 5 exercises - single leg squats, dead lift, single leg raises, lateral step-ups and forward reach outs. routine back exercises includes 5 sets - pelvic bridges, dynamic dead bug, prone planks, situps, lateral planks. 10repetition maximum, 2 sets/ day, five days a week, 2 weeks. baseline balance (star edward, berg balance) and functional test (sit to stand) and pain (visual analogue score) and post 2 weeks outcome scores will be analysed through paired and unpaired for between and within groups.

Eligibility criteria:
inclusion criteria: * non specific low back pain diagnosed by orthopedical surgeon or physiatrist * both genders * age 25 - 45 years (to avoid age related balance deficit) * should have balance deficit percentage (\> 20%) through balance assessment scale exclusion criteria: * h/o benign paroxysmal positional vertigo * neuromuscular disorders(stroke, polio, potts spine, spinal stenosis) affecting balance * any form of ear infection * recent ear, nose, throat surgery * recent surgery in abdomen, thorax, head (\< 2 years) * recent lower limb surgeries, injuries (\< 6 months) * any form of walking aids (cane, walker)

Keywords: balance training low back pain balance test routine back exercise
a pathophysiological study of the postprandial human liver (pls)

Conditions: Cirrhosis; Fatty Liver

Summary: fatty liver disease is a globally widespread disease the identification of valid biomarkers and targets for potential treatments requires in-depth knowledge about the pathophysiology of the postprandial liver. the study will consist of five work packages (wp) including blood tests and liver biopsies taken after fasting or ingestion of a standardized meal in: healthy controls (wp 1), patients with nafld (wp 2), and patients with cirrhosis (wp 3) ; before and after a standardised meal in healthy controls (wp 4), and before and after glucagon in healthy controls (wp5)


Eligibility criteria:
healthy participants (wp 1 , wp 4 , wp 5 ) inclusion criteria: healthy adults, 20 - 40 years old, non-smoker, bmi 20-25 kg/m2 , no chronical illnesses, no medication. exclusion criteria: blood donation within the past 3 months, acute illness within 2 weeks nafld ( wp 2) inclusion criteria: patients with clinical diagnosis of nafl and indication for liver biopsy exclusion criteria: malignant disease, acute illness within the past 2 weeks. cirrhosis (wp 3) inclusion criteria: patients with clinical diagnosis of cirrhosis and indication for liver biopsy. exclusion criteria:malignant disease, acute illness within the past 2 weeks.
intracranial neurophysiological signatures of fear and anxiety in humans

Conditions: Fear; GAD; Emotional Memory; PTSD

Summary: anxiety disorders such as post-traumatic stress disorder (ptsd) and generalized anxiety disorder (gad) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. the purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. to accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. these tasks will expose the participants to various levels of fear-provoking images.


Eligibility criteria:
inclusion criteria: * 12 years of age or older * has undergone acute depth or chronic responsive neurostimulation (rns) electrode placement * willing to provide informed consent and participate in the study ability to read and write english fluently exclusion criteria: * unwilling to provide informed consent * has not undergone acute depth or chronic responsive neurostimulation (rns) electrode placement * pregnant women * participants with active psychosis * participants with suicidal ideation * participants with substance abuse issues
the assessment of preoperative psychological intervention on stress in women with gynecological malignancies

Conditions: Cancer of Cervix; Ovarian Cancer; Cancer of Endometrium

Summary: the purpose of this study is to asses the impact of a tailored preoperative psychological intervention on women with gynecological malignancies on psychological, physiological and immunological parameters

surgery is considered one of the most stressful events in human life. research indicates that patients show high levels of stress from at least six days before surgery and up to a week post the operation. stress levels return to normalcy only after several weeks. research shows that psychological interventions given to women suffering from cancer can improve their coping abilities and overall function, decreases stress levels, enhances adherence to treatments,and increases quality of life and even life expectancy. women enrolled in this study will be divided into two groups: an experimental group and a control group. both groups will receive standard care. the control group will interact with a nurse for one hour. the experimental group will receive one of two forms of psychological intervention: either a cognitive intervention, or a psychophysiological intervention (tailored to each woman). measurements and instruments include: 1) self-report questionnaires, such as:profile of mood states (poms-sf),coping inventory (cope), life orientation test revised (lot- r),stress level report, 2) demographics, 3) global assessment by the head nurse. 4)physiological and behavioral measures, such as: vital signs and use of medicine. 5)hormonal and immunological measures: levels of cortisol in saliva and plasma, levels of catecholamines in plasma, salivary levels of iga1, and peripheral blood nk cells and lymphocyte phenotyping.6)levels of cytokines including il-1,2,4,6,10,12, tnf-alpha, interferon-gamma. time intervals for the collection of blood and saliva and the administration of the questionnaires: during the first week after being given the diagnosis and prior to the intervention:blood \& saliva, stress level report, poms-sf, cope, lot-r a day prior to surgery:blood \& saliva, stress level report on discharge from hospital:blood \& saliva, stress level report 30 days after surgery:stress level report,poms-sf,cope,lot-r.

Eligibility criteria:
inclusion criteria: * woman with ovarian, cervical or endometrial cancer/tumor * women who speak hebrew * women who sign the consent form exclusion criteria: * women who have received neoadjuvant treatment * women suffering from any form of depression, anxiety or schizophrenia * women suffering from autoimmune or infectious diseases * women taking medications which have immunological effects (steroids ,beta-blockers) * women suffering from dementia or concentration problems
the impact of nerve cross section area on sensory block onset

Conditions: Regional Anesthesia

Summary: the study aims to describe a correlation between the nerve cross section and the sensory or motor block onset time. therefore, different nerve cross sections with their motor and sensory onset times are compared in order to find a correlation. in the case of discovering a correlation, this could be translated into clinical practice, where a more tailored and individualized approach to performing peripheral nerve blocks would be possible, thus lowering the risks of adverse events occurring.


Eligibility criteria:
inclusion criteria: * asa i - ii, both sexes * ≥ 18 years old * \< 65 years old * written informed consent as documented by signature exclusion criteria: * known allergy or hypersensitivity to a study drug or class of drug. * severe coagulopathy. * history of alcohol abuse or the intake of psychotropic drugs. * pregnancy. * infection at the injection site or a systemic infection. * fever of unknown origin. * motor or sensory abnormalities in the arm. * previous enrollment into the current study

Keywords: ultrasound-guided regional anesthesia
anti-cd5 car t cells for relapsed/refractory t cell malignancies

Conditions: T-cell Acute Lymphoblastic Leukemia; T-cell Non-Hodgkin Lymphoma

Summary: this is a phase i, interventional, single arm, open label, treatment study to evaluate the safety and tolerability of anti-cd5 cart cells in patients with relapsed and/or refractory t cell lymphoma or leukemia.

anti- car is a chimeric antigen receptor immunotherapy treatment designed to treat lymphoma/leukemia expressing cd5 antigen. cd5+ t cell lymphomas or leukemia are a subset of leukemias and lymphomas that are positive for the surface protein cd5. the purpose of this study is to evaluate the efficacy and safety of anti-cd5 car t cells.

Eligibility criteria:
inclusion criteria: 1. signed written informed consent; patients volunteer to participate in the research 2. diagnosis is mainly based on the world health organization (who) 2008 3. patients have exhausted standard therapeutic options 4. systematic usage of immunosuppressive drug or corticosteroid must have been stopped for more than 1 weeks 5. female must be not pregnant during the study exclusion criteria: 1. patients declining to consent for treatment 2. prior solid organ transplantation 3. potentially curative therapy including chemotherapy or hematopoietic cell transplant 4. any drug used for gvhd must be stopped \>1 week

Keywords: anti-cd5 car t cell leukemia/lymphoma t-all
a study of an investigational medication for the treatment of secondary hyperparathyroidism in dialysis patients

Conditions: Secondary Hyperparathyroidism; End Stage Renal Disease

Summary: this 6 month long study will assess an investigational medication for patients on dialysis with secondary hyperparathyroidism. the study will look at the effects on parathyroid hormone, calcium and phosphorus levels.


Eligibility criteria:
* patients must be receiving hemodialysis; \* have elevated parathyroid hormone levels; \* not be pregnant or nursing; and \* not have had a heart attack in the last 3 months.
a study to evaluate rist4721 in palmoplantar pustulosis (ppp)

Conditions: Palmoplantar Pustulosis

Summary: a randomized, double-blind, placebo-controlled, phase 2a study to evaluate the efficacy and safety of rist4721 in subjects with palmoplantar pustulosis


Eligibility criteria:
inclusion criteria: * at least a 6-month history of ppp as defined by the presence of pustules on palms and/or soles, but without evidence of infection on palms and soles * moderate or severe ppp, as defined by palmoplantar pustulosis psoriasis area and severity index (pppasi) ≥8 and palmoplantar pustulosis physician global assessment (pppga) ≥3 at day -1, and a minimum of 8 fresh pustules at screening (fresh pustule count on both right/left palms and soles) and 20 fresh pustules at day -1 (fresh pustule count on both right/left palms and soles) * males and females must be willing to use birth control as indicated exclusion criteria: * moderate to severe psoriasis, as defined by plaque psoriasis covering ≥10% of total body surface area (bsa) at day -1 * subject is known to have an immune deficiency or is immunocompromised * positive test for hepatitis, human immunodeficiency virus (hiv) or tuberculosis * use of topical therapies for ppp within 2 weeks of day -1 and/or systemic therapies for ppp within 4 weeks

Keywords: ppp