Kornimate/medical-research-clean huggingface dataset:
opiate use and biliary dilation

Conditions: Evaluation of Association Between Opiate Use and Biliary Dilation

Summary: we hope to better define the association between opiate use and biliary dilation, which was evident in our previous retrospective study. this prospective study including all endoscopic ultrasound procedures performed for further evaluation of biliary dilatation in the setting of bilirubin \<2 mg/dl will enable accurate measurement of common bile duct and pancreatic duct diameter using endoscopic ultrasound and identification of other non- obstructive factors which may modulate biliary dilation (i.e. age, cholecystectomy status, duration and type of opiate used).

we hope to better define the association between opiate use and biliary dilation, which was evident in our previous retrospective study. this prospective study including all endoscopic ultrasound procedures performed for further evaluation of biliary dilatation in the setting of bilirubin \<2 mg/dl will enable accurate measurement of common bile duct and pancreatic duct diameter using endoscopic ultrasound and identification of other non- obstructive factors which may modulate biliary dilation (i.e. age, cholecystectomy status, duration and type of opiate used). we believe this work will be of great interest to gastroenterologists, as it provides additional data for interpretation of isolated common bile duct dilation in asymptomatic patients.

Eligibility criteria:
inclusion criteria: 1. referral/consultation for consideration for eus ± ercp 2. age 18 and older 3. evidence of biliary dilation on abdominal imaging without obstructive pattern on liver function tests or imaging. 4. willing and able to comply with the study procedures and provide written informed consent to participate in the study. exclusion criteria: 1. age \<18 2. potentially vulnerable subjects including, homeless people, pregnant females, employees and students. 3. participation in another investigational study that may directly or indirectly affect the results of this study within 30 days prior to the initial visit 4. other biliary process which accounts for patient's abnormal liver function studies/imaging (i.e. mass, stone, cirrhosis).
intraoperative near infrared spectroscopy of kidney for prediction of acute and sub-acute kidney injury in partial nephrectomy

Conditions: Kidney Injury

Summary: intra-operative nirs measurements of kidney during partial nephrectomy, after reperfusion, for monitoring ischemia and prediction of postoperative renal dysfunction.


Eligibility criteria:
inclusion criteria: * candidates for partial nephrectomy at tel aviv medical center who will consent to participate. exclusion criteria: * patients unable to give consent, * patients who were lost to follow up during the first 7 post-operative days.
here, my voice 2 voice lessons pilot

Conditions: Hearing Loss

Summary: active music engagement has been shown to provide unique benefits for both pediatric and adult cochlear implant (ci) users. here, my voice 2 (hmv 2) project will build upon the 2021 pilot program and provide personalized voice lessons to members of the hard-of-hearing (hoh) community in order to support the (re)discovery of their voice as a tool of self-expression. over the course of 12 weeks, participants from the hoh community will partner with students from usc's thornton school of music to practice expressive vocal techniques in one-on-one individual lessons. at the conclusion of the lessons, hlaa will host a communal session with a recital in which each team will present what they have worked on. data will be collected via self-assessment surveys, vocal assessment measures, and interviews at the beginning, middle, and end of the program, as well as a 3 month follow-up. this data will be quantified/coded using qualitative coding, as appropriate, and the findings will be published in relevant conferences and journals. the data will also be used to evaluate the merits of this program to improve the format in future iterations.


Eligibility criteria:
inclusion criteria: * adults, english speaking, who experience profound hearing loss and use cochlear implants or/and hearing aids. * ability to use voice without discomfort and without causing any health issues. * ability to commit one hour a week over a 12-week period and an additional 10 min period of daily training. exclusion criteria: * people with medical conditions such as tracheostomy, which makes using voice difficult and potentially threatens their health * people taking part in other training programs for vocal, musical or auditory skills in the same time period

Keywords: cochlear implants voice lessons
a study of extended-release (er) niacin/laropiprant in adolescents with heterozygous familial hypercholesterolemia (mk-0524a-158)

Conditions: Hypercholesterolemia, Familial; Heterozygous Familial Hypercholesterolemia

Summary: the purpose of this study is to determine the pharmacokinetics of laropiprant following administration of a single dose of 1 (panel a) and 2 (panel b) combination tablets of mk-0524a in adolescents with heterozygous familial hypercholesterolemia.


Eligibility criteria:
inclusion criteria: * post-pubescent adolescent age 10 to 16 with heterozygous familial hypercholesterolemia * agree to use (and/or have their partner use) acceptable methods of birth control beginning at the prestudy visit until at least 2 weeks after dosing of study drug * height and weight fall between the 10th and 95th percentile for age with a minimum body weight of 23 kg * receiving appropriate medical care for hypercholesterolemia, such as a statin or other lipid-modifying therapy. exclusion criteria: * history of psychiatric or personality disorders that may affect the patient's ability to participate * history of stroke, chronic seizures, or major neurological disorder * history of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, or genitourinary abnormalities or diseases (excluding lipid abnormalities) * poorly controlled or recently diagnosed type 1 or type 2 diabetes mellitus * history of neoplastic disease within previous 5 years * consumes alcohol or excessive amounts of products that contain caffeine (e.g. cola) * has had major surgery, donated and/or received blood within previous 8 weeks * participated in another investigational study within previous 4 weeks * history of significant multiple and/or severe allergies (including latex allergy), or has had an anaphylactic reaction or significant intolerability to prescription or non-prescription drugs or food * positive for hepatitis b surface antigen, hepatitis c antibodies or human immunodeficiency virus (hiv) * cannot swallow large tablets * pregnant or breastfeeding
hospital based continuous patient monitoring system

Conditions: Trauma; Appendectomy; Pediatric ALL; Vital Signs Monitoring

Summary: in ghana, and many other low and middle income countries in africa, manual vital signs monitoring is the prevalent mode of vital signs monitoring because continuous bedside monitors are non-functional. this lack of continuous vital signs monitoring may result in missed opportunities to catch physiologic deterioration. the investigators propose to develop a dashboard that is based on the fitbit, a consumer wearable device that reliably measures heart rate, spo2, and respiratory rate, as an alternative to bedside monitors in hospitals in ghana.

vital sign (vs) monitoring is a universal tool used to assess patients' basic physiologic status, primarily to detect physiologic deterioration indicative of clinically meaningful events. physiologic deterioration occurs relatively commonly in trauma and postoperative patient populations. in most high-income countries (hic), such patients are therefore monitored by automated, continuous, bedside vs systems, while, in many low-and middle-income countries (lmic), manual, intermittent (from every 15 minutes to every 6 hours) vs monitoring is still widely employed. the investigators propose to further refine and scale up a consumer-grade wearable monitoring system to improve outcomes in low resource settings (consol) in ghana. consol is a cwd based platform, developed by the mpis, that collects and displays in near real time, hr, skin temperature, rr, and spo2, with snapshots of the past 1 minute, and 1, 4, and 24 hours, viewable on an ipad or smartphone. the investigators propose to evaluate the use of consol for vs monitoring of (a) pediatric trauma patients in the emergency department (ed) and (b) pediatric postoperative appendicitis patients on a surgical unit, given higher risk of physiologic deterioration indicative of clinically meaningful events in these patient populations, and because pediatric patients are often more limited, than adults, in their ability to communicate about signs and symptoms.

Eligibility criteria:
inclusion criteria: * pediatric patients presenting with traumatic injury * pediatric patients postoperative status after an appendectomy exclusion criteria: * pediatric patients missing their upper limbs, * pediatric patients who cannot wear a fitbit on their wrist for known allergies to rubber or those with traumatic or medical conditions that prevent them from being able to comfortably wear a fitbit on either hand

Keywords: fitbit pediatric appendectomy trauma vital sign monitoring
the psychiatric rehabilitation approach to weight loss

Conditions: Schizophrenic Disorders

Summary: the primary aim of the project is to examine the efficacy of the psychiatric rehabilitation weight loss program in reduction of weight and body mass index (bmi.

the study involves 144 individuals who will be randomly assigned to the intervention group or treatment as usual group(control group). all participants will undergo baseline assessment, assessment at week 12, week 24 and in year from baseline.

Eligibility criteria:
inclusion criteria: * a diagnosis of serious mental illness, * age 18 - 65 * bmi \> 25 * medication stable (there have been no changes in antipsychotic medications or mood stabilizers for the last 3 months). exclusion criteria: * current or history of eating disorder * pregnant or breast feeding * uncontrolled htn * severe coronary artery disease * severe valvular disease * uncontrolled diabetes * sustained arrhythmia * insulin using severe physical limitations * severe lung disorders * diagnosis of mr or dementia
pulmonary vein isolation in athletes

Conditions: Athletes; Atrial Fibrillation; Catheter Ablation

Summary: pulmonary vein isolation (pvi) has become a common and effective treatment for paroxysmal and persistent atrial fibrillation (af), particularly in patients with drug-refractory disease. intense endurance exercise is a known risk factor for atrial fibrillation. in general, these athletes poorly tolerate most common antiarrhythmic drugs used for atrial fibrillation control and often pvi is recommended for durable management. while the efficacy of pvi in athletes is similar to the general af population, some athletes with lone atrial fibrillation report a reduction in subjective exertional capacity following pvi, despite maintenance of sinus rhythm and absence of pulmonary vein stenosis on imaging. the investigators hypothesize that pvi may alter pulmonary vein function and affect peak exercise performance. the investigators propose a small, prospective study of endurance athletes undergoing antral pvi for treatment of lone atrial fibrillation. peak metabolic performance and pulmonary vein function will be assessed pre- and post-pvi by metabolic stress testing and cardiac mri, respectively.

endurance athletes with paroxysmal or persistent atrial fibrillation undergoing primary pulmonary vein isolation will be prospectively enrolled prior to pvi. patients will undergo metabolic exercise stress testing as well as resting cmr 1-4 weeks prior to pvi. metabolic stress testing and cmr will be repeated at 6 month follow-up. quality of life questionnaires will also be collected at pre- and post-pvi visits. metabolic treadmill stress testing will follow standard protocol and measure hemodynamics with escalating metabolic output and characterize peak exercise capacity (mets) and oxygen consumption (vo2 max). cmr evaluation will include standard anatomic imaging of pulmonary vein and left atrial anatomy at rest. additional cine cmr sequences willbe included for focused evaluation of dynamic pulmonary vein cross-sectional area. 3d navigator whole heart imaging and mra (single gadolinium dose) will be obtained to measure pulmonary vein flow. cmr sequences to characterize left atrial function, including phasic volumes and emptying fractions (total, passive, active) will also be performed. data on heart rate variability will additionally be collected at pre- and post-pvi clinic visits, as well as the morning after pvi (hospital day 1).

Eligibility criteria:
inclusion criteria: * paroxysmal or persistent af * endurance or highly trained athletes (\>3h training/week for \>10 yrs) * nsr at time of stress testing exclusion criteria: * structural heart disease; lvef \<45% * moderate or severe valvular disease * egfr \< 30 * contraindication to mri * less than average functional capacity * previous episode of af of \>14 days duration * previous pulmonary vein isolation * imaging evidence of pulmonary vein stenosis

Keywords: atrial fibrillation, athletes, pulmonary vein isolation
iolmaster 700 central topography workflow study.

Conditions: Cataract

Summary: the use of ocular biometers like iolmaster 700, is a common practice to identify several ocular parameters such as the keratometry of the cornea and the axial length of the eye, which are necessary for calculating the power of the intraocular lens in cataract surgery. however, the additional use of other devices, such as cassini and pentacam is used to obtain more information of the central topography of the eye. recently, a new version of the iolmaster 700 equipment that provides much more detailed information than in its previous version has been presented. the objective of this study is to measure the time that the new iolmaster 700 takes to perform these measurements of the central topography and compare it with the time it takes using the central topography using the standard iolmaster 700 version with cassini on one hand and pentacam on the other. it is hypothesized that the use of the new version of the iolmaster 700 equipment alone can reduce the time of measurements and improve the clinic workflow.


Eligibility criteria:
inclusion criteria: * patients that have to undergo a cataract surgery * patients older than 50 years. exclusion criteria: * patients that have already undergone a previous corneal surgery. * patients suffering from keratoconus. * patients exhibiting corneal scars * patients exhibiting pterygium
does adolescent idıopathic scoliosis cause pelvic floor dysfunction?

Conditions: Scoliosis Idiopathic; Pelvic Floor Disorders

Summary: the aim of this study was to investigate relationship between the type and severity of scoliosis and pelvic floor dysfunctions in individuals with adolescent idiopathic scoliosis.

while a healthy spine has a flat appearance in the axial line in the frontal plane, individuals with scoliosis have lateral flexion to one side and rotation deformity in the horizantal plane. in other words, it is a 3-dimensional problem that causes severe postural disorder in advanced stages, accompanied by lateral flexion of the spine of 10 degrees or more in the frontal plane, axial rotation in the transverse plane and kyphosis-lordosis deformity in the sagittal plane. especially the "core" region, which is formed by 4 main muscle groups, stabilizes the pelvic organs by balancing intra-abdominal pressure increases and provides spinal stabilization. studies showing that pelvic floor functions may be affected in normal spinal physiologic curvature changes are available in the literature. however, the relationship between the angle and severity of scoliosis and pelvic floor dysfunctions due to idiopathic scoliosis has not been clearly clarified. in this context, the study aims to evaluate and compare scoliosis-related parameters (type of scoliosis, cobb angle, axial rotation angle), pelvic floor dynamics and dysfunctions in individuals with idiopathic scoliosis and healthy individuals with the same age group and characteristics.

Eligibility criteria:
inclusion criteria: * those with adolescent idiopathic scoliosis diagnosed above 10' degree, * under 19 years of age diagnosed with ais, * individuals whose consent was obtained from their families to participate in the study exclusion criteria: * those with congenital scoliosis, * those with a history of neuromuscular disease, * diagnosed with any systemic disease other than ais, * those with a history of malignancy and/or ongoing treatment, * those with a history of urogenital diseases and surgical history, * individuals with previous spinal surgery
sensory distraction tools on anxiety management in pediatric dental patient

Conditions: Anaesthesia; Anxiety; Children

Summary: the goal of this clinical trial is to evaluate the effectiveness of visual and sensory distraction prior to inferior alveolar nerve block administration in healthy children of both genders, aged 4-6 years. the main questions it aims to answer are: * how effective are different visual and sensory distraction techniques in reducing pain and anxiety during inferior alveolar nerve block procedures in young children? * which type of distraction technique (visual or sensory) is the most effective? this study will compare children receiving visual and sensory distraction with those receiving no distraction to assess differences in pain perception and anxiety levels during the procedure. participants will: * undergo a standardized inferior alveolar nerve block procedure. * be randomly assigned to one of the following groups: visual distraction, sensory distraction, or control (no distraction). * complete simple self-reported pain and anxiety assessments appropriate for their age (such as the wong-baker faces pain rating scale). * be evaluated using additional objective measures, including the flacc scale and heart rate monitoring.

dental anxiety is considered one of the most common challenges in pediatric dentistry, as it directly affects - and may limit - a child's cooperation during treatment. distraction techniques work by diverting the child's attention away from painful or difficult therapeutic procedures and are considered highly important in managing children's behavior within the dental clinic. various visual and/or auditory distraction methods can be employed by the dental team when working with pediatric patients. distraction techniques may be either active (such as allowing the child to play electronic games) or passive (such as listening to music or watching animated movies). these techniques are considered a valuable alternative to pharmacological preparation for completing dental treatments in children, and many pediatric dentists have adopted them as an effective strategy for managing dental anxiety in young patients. despite the availability of numerous behavioral management techniques for addressing dental anxiety, the effectiveness of different distraction methods - whether visual, sensory, or a combination of both - still requires further investigation.

Eligibility criteria:
inclusion criteria: 1. no previous dental experience. 2. definitely positive or positive ratings of frank scale. 3. need of ian block for any dental treatment. exclusion criteria: 1. previous dental experience 2. systematic or mental disorders. 3. definitely negative or negative ratings of frankel scale 4. any contraindication for regional anesthesia

Keywords: behavior management distraction techniques pain
reversal of dabigatran anticoagulant effect with idarucizumab

Conditions: Hemorrhage

Summary: evaluate the reversal of the anticoagulant effects of dabigatran by iv administration of 5.0g idarucizumab in patients treated with dabigatran etexilate who have uncontrolled bleeding or require emergency surgery or procedures.


Eligibility criteria:
inclusion criteria: * group a (bleeding patients) * overt bleeding judged by the physician to require a reversal agent * currently taking dabigatran etexilate * at least 18 years of age * written informed consent * group b (patients who are taking dabigatran who may not be bleeding, but do require an emergency surgery or procedure for a condition other than bleeding * condition requiring emergency surgery or invasive procedure where adequate hemostasis is required. emergency is defined as within the following 8 hours. * current treatment with dabigatran * at least 18 years of age * written informed consent. exclusion criteria: * group a (bleeding patients) * patients with minor bleeds (epistaxis, hematuria) who can be managed with standard supportive care. * patients with no clinical signs of bleeding * contraindications to study medication including known hypersensitivity to the drug or its excipients. * group b (patients who require emergency surgery or procedure) * a surgery or procedure which is elective or where the risk of uncontrolled or unmanageable bleeding is low. * contraindications to study medication including known hypersensitivity to the drug or its excipients (subjects with hereditary fructose intolerance may react to sorbitol).