Kornimate/medical-research-clean huggingface dataset:
botox® treatment in adult patients with post-stroke lower limb spasticity

Conditions: Muscle Spasticity

Summary: this study will evaluate the safety and efficacy of botox® in the treatment of adult post-stroke lower limb spasticity.


Eligibility criteria:
inclusion criteria: * diagnosis of post-stroke lower limb spasticity for at least 3 months * minimum body weight of 50 kg * never treated with botulinum toxin of any serotype for any reason, or if previously treated with botulinum toxin of any serotype, if previously treated for spasticity in the affected lower limb, must have been administered * 20 weeks before day 1, or if previously treated for any other indication must have been administered ≥12 weeks prior to day 1 exclusion criteria: * spasticity in the opposite leg that requires treatment * casting of the study limb within 6 months or planned casting during the first 12 weeks of the study * treatment modalities in the study limb including ultrasound, electrical nerve stimulation, electrical stimulation, acupuncture within 1 month of day 1 or treatments planned during the study * not able to perform 10 meter walking test independently with or without assistive device * diagnosis of myasthenia gravis, eaton-lambert syndrome, or amyotrophic lateral sclerosis
evaluating pancreatic tumors in patients with zollinger-ellison syndrome

Conditions: Zollinger Ellison Syndrome

Summary: this protocol concerns the approach to the localization, diagnosis of men1 and management of the tumor and the tissue samples in patients with zollinger-ellison syndrome. it details the diagnostic imaging tests to be used to localize the tumor, investigations for men1 the subsequent management of the tumor and tissue samples for research....

this protocol concerns the approach to the localization and management of the tumor in patients with zollinger-ellison syndrome. it details the diagnostic imaging tests to be used to localize the tumor and the subsequent management of the tumor.

Eligibility criteria:
* inclusion criteria: new patients will be evaluated initially as described in the protocol entitled, "diagnostic evaluation of patients with suspected abnormalities of gastric secretion" (89-dk-0005). only those patients that are being treated under the protocol entitled, "medical therapy of zollinger-ellison syndrome" (protocol # 89-dk-0015) will be entered into this tumor localization and management protocol.

Keywords: zollinger-ellison syndrome natural history
extension study to assess persistence of benefit of libigel for the treatment of hypoactive sexual desire disorder (hsdd)

Conditions: Hypoactive Sexual Desire Disorder

Summary: the objective of this study is to evaluate the persistence of benefit of libigel (testosterone gel) 300 mcg/day compared to placebo gel in a 12 week post-treatment period of hypoactive sexual desire disorder (hsdd) in surgically menopausal women.


Eligibility criteria:
inclusion criteria: * must have completed a minimum of 22 weeks of the 24-week testw006 or testw008 clinical trial exclusion criteria: * any condition (including a change in sexual or relationship history) that would make the subject unsuitable for participation in the trial in the opinion of the investigator

Keywords: testosterone hypoactive sexual desire disorder menopause
time to defibrillation using automated external defibrillators by pediatric residents in simulated cardiac arrests

Conditions: Pediatric Residents

Summary: automated external defibrillators have improved survival for adult in hospital cardiac arrest. automated external defibrillators are approved for children aged 1 year and older for out of hospital cardiac arrests. it is unknown whether automated external defibrillators have a role for in hospital pediatric cardiac arrests. the purpose of study is to compare the management of cardiac rhythm disorders by pediatric residents using an automated external defibrillator versus a standard defibrillator in simulated pediatric cardiac arrests. it is our hypothesis that residents using an automated external defibrillator will have a shorter time to defibrillation.


Eligibility criteria:
inclusion criteria: * pediatric resident at baylor college of medicine exclusion criteria: * not a pediatric resident at baylor college of medicine

Keywords: automated external defibrillator resuscitation pediatric
study of prevalence and clinical phenotype in patients with glucocorticoid-remediable aldosteronism

Conditions: Hyperaldosteronism

Summary: objectives: i. determine the prevalence of glucocorticoid-remediable aldosteronism (gra) in various hypertensive populations and screen at risk members of gra pedigrees. ii. investigate other factors regulating blood pressure in gra (environmental, genetically determined factors). iii. investigate renal and hormonal mechanisms regulating potassium homeostasis in gra. iv. describe clinical phenotype of gra patients. v. prospectively screen gra-affected patients with mri angiography for intracranial aneurysm.

protocol outline: patients are screened for high blood pressure, suppressed plasma renin activity level, and low potassium levels. urine is collected for a 24 hour period. blood specimen is collected for molecular biologic evaluation for the presence of the chimeric gene diagnostic of gra. any history of cardiovascular events is recorded.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- diagnosed glucocorticoid-remediable aldosteronism (gra) with hypertension hypokalemia is variably seen blood pressure variably elevated elevated level of aldosterone low level of plasma renin activity

Keywords: endocrine disorders genetic diseases and dysmorphic syndromes hyperaldosteronism rare disease
rehabilitation gaming system for cerebral palsy

Conditions: Cerebral Palsy; Movement Disorder

Summary: in this study the investigators evaluate the effectivity of virtual reality-based rehabilitation protocols for preventing motor deterioration in patients with cerebral palsy.


Eligibility criteria:
inclusion criteria: * children and adult patients between 12- 50 years old diagnosed with cp according to gross motor function classification system (gmfcs). level of disability between i and iv. * ashworth modified clinical scale \< 3 (ashworth, 1964, bohannon bohannon and smith, 1987). exclusion criteria: * severe visual impairment. * severe cognitive impairment such as mental retardation which impedes the understanding of the task.

Keywords: hemiparesis functional independence virtual rehabilitation
withings pulse wave velocity and blood pressure study

Conditions: Elevated Blood Pressure; Hypertension; Mental Stress; Sleep Disorders

Summary: measure pulse wave velocity stability in relation to time of day, day of the week, physical activity, sleep quality, stress levels and blood pressure.

the study population will be an estimated 300 healthy adult subjects from the united states. this population will be approximately 150 men and 150 women. in order to obtain a relatively diverse age range of users (with varying levels of arterial stiffness), we hope to enroll participants across three age ranges entered in the withings application by the user: 18-40 years, 41-60 years, and \> 60 years. these spots will be filled by those that satisfy the inclusion/exclusion criteria on a first come, first served basis.

Eligibility criteria:
inclusion criteria: * user of a (1) withings blood pressure cuff (2) withings activity tracker and (3) withings body cardio scale * user has measured their blood pressure at least once per week for the majority of weeks over the last three months. exclusion criteria: * aortic artery disease * peripheral vascular disease * atrial fibrillation * weight \> 396 lbs. * pregnant women
dual task training in elderly using the biorescue

Conditions: Mild Cognitive Impairment

Summary: mild cognitive impairment (mci) is accompanied by gait and balance problems while dual tasking. during a 6 to 8 weeks training with the biorescue (virtual reality), institutionalized elderly people with mci will relearn dual tasks in combination with balance. afterwards, the transferring effect on gait in general, balance and cognition will be examined.


Eligibility criteria:
inclusion criteria: * minimum age: 65 * participants with increased fall-risk (i.e. timed up-and-go test (tug) \> 20 sec) * participants with mild cognitive impairment (mci) measured by the montreal cognitive assessment (moca \< 25). mci: a state of altered cognition, characterized by a decline in one or more cognitive domains, typically including memory while the independence for daily activities remains intact. * participants have a positive result on the 'stops walking while talking' test exclusion criteria: * diagnosis of dementia, based on a specialized diagnostic bilan of a doctor-specialist. * in rehabilitation for a recent injury or recent prothesis of the upper or lower extremities. * serious limitations of the lower and or upper limb. * not able to walk more than 10 meters independently (walking-aid allowed).

Keywords: elderly
the life style patterns and the development trend of chronic diseases in healthy and sub-healthy groups were analyzed by using data-mining techniques

Conditions: Chronic Kidney Disease Stage 1; Chronic Kidney Disease Stage 2; Chronic Kidney Disease Stage 3; Chronic Kidney Disease Stage 4; Chronic Kidney Disease Stage 5; Metabolic Syndrome; Chronic Disease

Summary: used multi-year health examination member profile by multi-algorithms technology, to find comprehensive key hazard factors or important high-risk group components for metabolic syndrome and chronic kidney disease or more common chronic diseases.

the proportion of the population over the age of 65 in taiwan reached 7.10% in 1993. after taiwan became an 「aging country」, the originally slow growth of the elderly population (9.9% in 2006) started to increase, and it reached 14.05% in 2018, which was almost 2 times that in 1993. in addition, taiwan formally became an 「aged country」as defined globally. according to the statistical data from the ministry of the interior and the data from the national development council, it is estimated that the population over the age of 65 is rapidly growing. it is expected that 6 years later (by 2026), the elderly population in taiwan will exceed 20%. taiwan will formally become the「super-aged country」as defined globally, with a population structure similar to that in japan, south korea, singapore, and some european countries (department of statistics, 2018; national development council, 2019). in order to effectively prevent and treat chronic diseases of sub-health populations and develop health management prediction systems that have unlimited market opportunities and potentials, the author intends to extend the achievements of individual projects sponsored by the ministry of science and technology in recent years. by multi-year complete health examination member profile, this project used multiple algorithms, such as logistic regression (lr); classification and regression trees (cart); hierarchical linear modeling (hlm); random forests (rf); support-vector machines (svm); extreme gradient boosting (xgboost); light gradient boosting machine (lightgbm) and multiple analysis tools to explore the common potential health hazard variables of the sub-health population to establish a comprehensive assessment health management system that can detect chronic diseases early, the research results will be provided for reference in related fields.

Eligibility criteria:
inclusion criteria: * continuously health screening twice or more in mj health reports. * chronic kidney disease * metabolic syndrome * or more, common chronic diseases exclusion criteria: * participants who have received clinical treatment * subjects of other related research diseases
effects of physical activity on weight loss and weight maintenance in obese adults - three year follow-up study

Conditions: Obesity; Weight Loss; Physical Activity; Healthy Obesity, Metabolically

Summary: objective to study if exercise added to weight loss treatment at the beginning of the weight loss intervention or at 6 months could sustain the weight loss achieved or give extra boost for weight reduction. design 36-month, 4-group parallel, randomized trial. setting oulu, finland. participants 120 obese adults (body mass index ≥ 30). intervention participants were randomly assigned to behavioural modification (ibm) (n = 30), behavioural modification + exercise from 0 to 3 months (cwt1) (n = 30), behavioural modification + exercise from 6 to 9 months (cwt2) (n = 30), and a control group (con) (n = 30). questionnaires and measurements were performed at baseline, 3,9,4 and 36 months. the intervention consisted of an intensified weight loss period (1-12 months) followed by a weight maintenance period (13-36 months). intensified behavioural modification included 14 individual face to face meetings, eleven times with a personal therapist (qualified nurse) and three times with a nutritionist. weight maintenance period included six individual meetings with personal therapist. twelve weeks supervised exercise was offered three times a week, 40 minutes at a time. in the cwt1 group supervised exercise was offered at months 1-3 and in the cwt2 group at months 4-6. measurements body weight (primary outcome) and waist circumference (secondary outcome)


Eligibility criteria:
inclusion criteria: * body mass index \> 30 * age 18-64 exclusion criteria: * pregnancy * health reasons preventing exercise and exercise test * medication preventing exercise and exercise test * previously diagnosed diabetes

Keywords: obesity weight loss weight maintenance physical activity fitness
peek versus metallic attachment-retained obturators

Conditions: Maxillary Neoplasms

Summary: patients' satisfaction evaluation and radiographic evaluation of the terminal abutments of attachment- retained maxillary obturators with metal framework versus milled peek framework in the management of maxillectomy cases.

eighteen participants were randomly divided into three parallel groups (n=6). participants of peek group received attachment-retained obturators with milled peek framework, metal group received an attachment-retained obturator with metallic framework and conventional group received conventional clasp-retained obturators with metallic framework (control group). evaluation included radiographic evaluation and patients' satisfaction where two scales were followed in this study, including "the obturator functioning scale" and "the european organization for research and treatment of cancer head and neck 35" using one way anova test.

Eligibility criteria:
inclusion criteria: * patient underwent surgical removal of half of maxilla * participants with a sufficient number of natural teeth(class i and \\or class iv aramany classification) not less than 5 teeth, mouth opening is not less than 25 mm, intact soft palate, exclusion criteria: * participants are exposed to radiotherapy or chemotherapy during last year. * participant with congenital defect
prescribing lorazepam for iud insertion: pilot feasibility study

Conditions: Pain; IUD

Summary: the objective of this pilot study is to discuss the feasibility of prescribing lorazepam prior to iud insertion and of measuring effect of lorazepam on anxiety and pain with intrauterine device (iud) insertion. the target population for this study will be 25 adult participants scheduled for an iud insertion at a uw family medicine residency clinic. participants will be followed for 1 appointment visit.

the purpose of the research is to evaluate the feasibility of prescribing lorazepam and measuring its effect on anxiety and pain with iud insertion. the descriptive data from this study will be used to offer guidance for how to implement a larger scale study in the future. primary endpoint: assess preliminary differences in pain and anxiety scores pre-iud insertion and post-iud insertion using a mann-whitney u test. participants will score their anxiety and pain levels pre-procedure and post-procedure using a 10cm visual analogue scale. this will be a one arm trial where all subjects will receive 1mg lorazepam and 800mg ibuprofen prior to the procedure. secondary endpoints * discuss if there was a difference in pain and anxiety scores among nulliparous (no previous childbirths) and multiparous (one or more previous childbirths) participants. * summarize recruitment rates, adherence to lorazepam prescription, completion rates of questionnaires and scales * discuss participant's experiences with taking lorazepam and participating in the study * assess investigator's experience with the trial via a focus group

Eligibility criteria:
inclusion criteria: * participants who undergo iud insertion and complete the visual analogue scales to rate their anxiety and pain level prior to the procedure and after the procedure. * participants must have a driver take them to their appointment if they take lorazepam prior to their arrival at the clinic. * participants must have a driver take them home after the procedure as well. * participants must consent to email communication since they will sign the consent forms electronically exclusion criteria: * participants who do not show up for their appointment. * participants who receive cervical blocks or other analgesic method during iud insertion. * participants who have a history of substance use disorder. * participants who are taking medications with a central nervous system (cns) depressant effect (ex: opioids, benzodiazepines). * participants who are not able to sign an electronic consent form. * participants who do not have a driver to take them to their appointment and to take them home after the procedure. * participants who do not agree to sign consent forms electronically.

Keywords: iud insertion
small changes a one year protocol for weight management

Conditions: Obesity

Summary: a trial comparing treatment as usual with motivational interviewing focussed treatment in the 'small changes' programme.

a quasi-experimental design. with one arm focussed on 'treatment as usual' and the other on motivational interviewing. subjects were not randomly assigned but treated as two separate cohorts one running october 2011-october 2012 using the treatment as usual and a separate cohort running from october 2012 to october -2013 using motivational interviewing as the approach for treatment.

Eligibility criteria:
inclusion criteria: * body mass index equal to or greater than 30 kgm2
parenting with an autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: in many individuals, autism spectrum disorder (asd) is recognized and diagnosed late in adolescence or even in adulthood, despite the presence of long-standing impairments and distress. one area that has received little attention so far is research and interventions in clinical practice that relate to the experienced realities of parenthood for autistic adults or offer support in this context. the few existing research findings in this field suggest that parents with asd might face specific challenges. at the same time, there is a lack of empirical research on the experiences autistic adults have with parenthood, whether they perceive a need for specific support services, and, if so, what those services should look like. to fill this research gap, this study aims to examine the mental health, needs, and strengths of parents with asd. particular focus will be given to parental stress and difficulties in the areas of mentalization and emotion regulation, which can increase the risk of psychological comorbidities. using a mixed-methods approach, the study will investigate to what extent an already established parenting program or an adaptation thereof might be suitable to address the specific requirements of autistic parents and enhance their parenting skills.


Eligibility criteria:
in- and exclusion criteria for the study population: inclusion criteria: * parents who fulfill the main diagnosis of asd, including atypical autism (icd-10: f84.1) and asperger syndrome (icd-10: f84.5) * age ≥ 18 years * have a child aged 0 to 6 years exclusion criteria: * below-average general cognitive ability (according to clinical impression) * lack of german language skills * severe visual or hearing impairment (uncorrected) * serious neurological and psychiatric illnesses (e.g., epilepsy, psychoses) * acute suicidal tendencies (according to clinical findings) eligibility criteria for the control group inclusion criteria: * parents without a lifetime main diagnosis of a psychiatric illness (icd-10-gm-2016: f10 - f69) * age ≥ 18 years * have a child aged 0 to 6 years * matched to the study group in terms of age and gender exclusion criteria: * above-mentioned psychiatric diagnoses * below-average general cognitive ability * lack of german language skills * severe impairment of vision or hearing (not corrected)

Keywords: parenthood autism spectrum disorder preschool children
aquatic physical therapy in fibromyalgia

Conditions: Fibromyalgia

Summary: objective: to investigate whether patients undergoing aquatic physiotherapy in groups improve their functional capacity, by means of the distance covered in the six-minute walk test (6wt), and to compare this with a control group. methods: forty women that had not been practicing regular physical activity for one year were randomly allocated either to the study group (sg) to undergo an aquatic physiotherapy program in groups applied twice a week, including aerobic exercises, muscle strengthening and relaxation for 12 weeks, or to the control group (cg), which did not do any physical activity. both groups maintained their treatment with medications. all patients underwent two evaluations: one at the start and the other after 12 weeks.


Eligibility criteria:
inclusion criteria: * patients of both genders with a medical diagnosis of fs, without age restrictions and without impaired cognition, who had not been practicing regular physical activity for one year exclusion criteria: * presence of other rheumatic diseases and cardiovascular problems * smoking * absence of medical permission for swimming pool activities * starting other therapies, or changes to and/or discontinuation of medical treatment

Keywords: hydrotherapy, rct,
study to assess the efficacy and safety of "pílulas de lussen®" compared to the pyridium® in the symptomatic control of dysuria

Conditions: Dysuria

Summary: clinical study, prospective, comparative, randomized, double-dummy entry with random from a total of 80 patients, 40 patients will receive the test medication (pílulas de lussen®) plus placebo and 40 patients will receive the comparative (pyridium®) plus placebo.

phase iii clinical study, prospective, multicenter, double-blind, randomized, double-dummy to assess the efficacy and safety of "pílulas de lussen®" compared to the pyridium® in the symptomatic control of dysuria in 80 patients of either sex or race, older than 18 years, with symptoms of dysuria, 40 patients will receive the test medication (pílulas de lussen®) plus placebo and 40 patients will receive the comparative (pyridium®) plus placebo to evaluate the effectiveness and tolerability of 'pílulas de lussen' for symptomatic relief of dysuria.

Eligibility criteria:
inclusion criteria: * patients over the age of 18 years; * patients with symptoms of dysuria characterized by pain/burning sensation in the lower urinary tract and discomfort in urination; * patients who are female and are of childbearing age should use reliable method of contraception and have negative pregnancy test. * patients who consent to participate in the study. exclusion criteria: * patients with sensitivity to any component of the formula; * patients pregnant or lactating; * patients with a history of glaucoma, heart failure, cardiac arrhythmias, prostatic hypertrophy, paralytic ileus or pyloric stenosis; * patients with menorrhagia or heavy menstrual periods; * patients who need to use antibiotics or chemotherapy; * patients who can not follow the procedures shown in this clinical protocol.

Keywords: pílulas de lussen efficacy safety dysuria symptomatic control