Kornimate/medical-research-clean huggingface dataset:
benefits of standard ons in indian adults

Conditions: Poor Nutrition

Summary: this is a prospective, single arm, baseline-controlled multicenter study to observe benefits on oral nutritional supplement (ons) intake in adults with medical conditions associated with poor nutritional status.


Eligibility criteria:
inclusion criteria: * ambulatory adult patients \>or equal to 45 years of age * patients at the risk of malnutrition (mst \> or equal to 2) * patients who understand nature of the study, willing to participate in all scheduled visits and trial procedures \& provide a written informed consent. exclusion criteria: * subject using commercially available macronutrient food supplements or another ons * history or evidence of hypersensitivity to any component of study product * history of any gastrointestinal disorder/surgery that affects digestion and/or absorption of food * evidence of active tb, hepatitis b, hepatitis c or hiv infection, type 1 or type 2 diabetes mellitus, malignancy and any other disease affecting appetite and weight loss * history or evidence of any medical condition that in the opinion of investigator can interfere with the study assessment of outcome or patients with scheduled surgery during the duration of the study * subjects who are unlikely to comply with the study protocol or follow up regularly for study assessments * pregnant or lactating women
long-term study of gabapentin enacarbil (gen, xp13512) vs. placebo in patients with restless legs syndrome.

Conditions: Restless Legs Syndrome

Summary: the primary objective of this trial is to assess the maintenance of efficacy of gabapentin enacarbil (gen, xp13512) taken once daily in the long-term treatment of patients suffering from restless legs syndrome (rls).

this study was a multicenter, blinded, randomized withdrawal study in subjects with primary restless legs syndrome (rls). eligible subjects were initially enrolled in a 24-week single blind (sb) treatment period during which they received xp13512. subjects who completed the initial treatment period and met the responder criteria were then randomized 1:1 to receive either xp13512 or placebo during the 12-week double-blind (db) treatment period. the primary study objective was to assess the maintenance of efficacy of xp13512 1200 mg taken once daily in the long-term treatment of subjects with primary rls. the secondary study objectives were to assess maintenance of improvements in sleep outcomes and quality of life, and to assess the safety and tolerability of xp13512 in the treatment of primary rls subjects.

Eligibility criteria:
inclusion criteria: * patients with primary rls, based on the international rls study group diagnostic criteria. exclusion criteria: * a sleep disorder (e.g., sleep apnea) that may significantly affect the assessment of rls; * neurologic disease or movement disorder (e.g., diabetic neuropathy, parkinson's disease, multiple sclerosis, dyskinesias, and dystonias); * abnormal laboratory results, electrocardiogram (ecg) or physical findings; * pregnant or lactating women; * women of childbearing potential who are not practicing an acceptable method of birth control.
does fluticasone propionate reduce the late allergic reaction when the drug is given post-allergen?

Conditions: Mild Intermittent Asthma

Summary: the investigators propose a 3-treatment, placebo-controlled, double-dummy, double-blinded, randomized, crossover study in which single doses of placebo, will be compared to fluticasone propionate (flovent diskus) 250 mcg and budesonide 400 mcg administered after allergen challenge, at cessation of the early allergic reaction (at 20% fall in fev1 from post-allergen peak)

the aim of this pilot study is to evaluate whether fluticasone propionate affects the late allergic reaction after a single dose post-allergen challenge administered following cessation of the early allergic reaction. six subjects with mild asthma will be asked to volunteer for the study.the diagnosis of asthma will be and includes the presence of variable airflow limitation and ahr (pc20 methacholine \< 16 mg/ml). subjects will be asked to participate if they demonstrate an allergen-induced early and late asthmatic response of at least 20% and 15% reduction in fev1, respectively. the study will consist of 4 periods, composed of a screening allergen period with 3 subsequent allergen challenge/treatment periods. each period will be separated with a washout of at least 2 weeks. subjects who demonstrate a dual asthmatic response in the screening period will be selected for randomization to treatment.

Eligibility criteria:
inclusion criteria: * mild asthma * nonsmokers * allergen-induced early and late asthmatic response exclusion criteria: * no medication other than infrequent ( \< twice weekly) inhaled beta2-agonists * not be exposed to sensitizing allergens * asthma exacerbation or respiratory tract infection in the past4 weeks

Keywords: late allergic response fluticasone propionate
rct about two different regimens of clean intermittent catheterization in women with overt postpartum urinary retention

Conditions: Urinary Retention; Postpartum Period

Summary: a randomized controlled trial of two different regimens of intermittent catheterization in women with overt postpartum urinary retention. participants will be randomized to one of two groups with different cut-offs for accepted postvoid residual urine (150 ml vs 250 ml). primary endpoint is be the time to regain normal bladder function in each group. secondary endpoints are 1) presence/absence of bacteriuria or urinary tract infections, 2) the duration of hospital stay, 3) scores on the adapted version of the german pelvic floor questionnaire section about bladder function and postpartum symptoms. the calculated sample size is 96 (48 in each group).


Eligibility criteria:
inclusion criteria: * diagnosed overt postpartum urinary retention. * age ≥ 18 years at delivery date. * delivery at study site. * signed informed consent. exclusion criteria: * refusal to participate. * language barrier.

Keywords: postpartum urinary retention intermittent catheterization postvoid residual volume postpartum
neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in predicting the incidence of nausea and vomiting

Conditions: Hemophilia A

Summary: by comparing the incidence of ponv, the dosage of postoperative antiemetic drugs, the postoperative vas score and the utilization rate of pcia of hemophilia a patients in the nlr≥2 and nlr\<2 groups, investigators could find out the high value in the diagnosis of hemophilia a, which is helpful to guide the clinical diagnosis and treatment of hemophilia a.

hemophilia arthropathy is a debilitating complication of hemophilia that occurs primarily in severe forms with recurrent spontaneous intra-articular hemorrhage, with the knee being the most commonly affected joint. currently, total knee arthroplasty is the standard treatment for end-stage hemophilic arthropathy. due to the special disease of hemophilia, general anesthesia is often chosen as the preferred anesthesia method, and the risk of bleeding is lower than that of neuraxial anesthesia. however, 20 to 30 percent of surgical patients suffer from post-operative nausea and vomiting after general anesthesia. neutrophil to lymphocyte ratio and platelet to lymphocyte ratio have been suggested as parameters for the diagnosis and follow-up of inflammatory diseases, and inflammation has been found to increase the risk of ponv. however, for patients with hemophilia, no information is currently available on the relationship between the two. in this study, investigators intend to retrospectively analyze the clinical data of patients with hemophilia a in our hospital, explore the clinical value of preoperative nlr and plr in predicting nausea and vomiting after tka.

Eligibility criteria:
inclusion criteria: 1. the patients with hemophilia a undergoing unilateral total knee arthroplasty. 2. the age of the patients ranged from 18 to 70 years. 3. american society of anesthesiologists is graded as i\~iii 4. no history of mental illness 5. no history of antiemetic and anticholinergic drugs. 6. no history of serious gastrointestinal diseases. exclusion criteria: 1. patients who have received long-term steroid treatment 2. patients who need more than 2.5 mg neostigmine to reverse muscle relaxants 3. patients with previous malignant tumor, malabsorption, morbid obesity, hypogonadism, thyroid and parathyroid diseases and autoimmune diseases.

Keywords: neutrophil lymphocyte platelet hemophilia post-operative nausea and vomiting
methods of placental delivery and the amount of blood loss during cesarean section

Conditions: Complications; Cesarean Section

Summary: to compare between the effect of controlled cord traction and manual removal of the placenta on blood loss among women undergoing caesarean sections

cesarean section (cs) is one of the most commonly performed major abdominal operations in women worldwide and its rate is increasing dramatically every year. some of the reported short-term morbidities include hemorrhage, postoperative fever and endometritis. the method of delivering the placenta is one procedure that may contribute to an increase or decrease in the morbidity of cs. on an average 0.5-1 liter of blood is lost during cs, many variable techniques have been tried to reduce this blood loss. such techniques include finger splitting versus scissor cutting of incision, in situ stitching verses exteriorization and stitching of uterus , and finally spontaneous or manual removal of the placenta. two common methods used to deliver the placenta at cs are cord traction and manual removal. manual removal of the placenta which the obstetrician introduce his hand into the uterine cavity to cleave the placenta from the decidua basalis as soon as possible after the delivery of the infant and controlled cord traction in which the obstetrician do external uterine massage and gentle traction on the exposed umbilical cord to facilitate placental delivery. opinions differ about the best for placental delivery technique at cs. some trials showed a reduced risk of blood loss with controlled cord traction (3) and others showed that manual removal of placenta at cs do not increase perioperative blood loss. authors concluded that manual delivery of the placenta was significantly associated with greater operative blood loss and greater decrease in postoperative hemoglobin levels and postpartum maternal infectious morbidity but with shorter operative time compared with spontaneous placental separation . in addition, it is known that the blood loss at cs delivery is difficult to estimate, and numerous different methods including serial change in hematocrit (hct), hemoglobin (hb) level, visual estimation and the gravimetric method are described. a low, but significant, correlation was found between visually estimated blood loss and perioperative hemoglobin change in women delivering by cs. however, hemoglobin , hematocrit levels and visual estimation are the most commonly used technique for estimating blood loss at delivery.

Eligibility criteria:
inclusion criteria: - all informed and consented women undergoing elective or emergency cs will be legible for enrollment into the study exclusion criteria: * multiple gestation. * pregnancy below 34 weeks. * severe maternal anemia. * severe pre-eclampsia * prolonged labor. * prolonged rupture of the membranes with fever. * placental abruption. * placenta previa. * placenta accreta. * clotting disorders. * current or previous history of a significant disease including heart disease, liver, renal disorders.

Keywords: blood loss caesarean section placental delivery
waltz - wet age-related macular degeneration (amd) al-39324 treatment examination

Conditions: Age Related Macular Degeneration

Summary: the purpose of this study is to evaluate the safety, tolerability, and effects of investigational drug al-39324 for the treatment of wet amd.

following a single administration, patients will be followed for 6 months postinjection.

Eligibility criteria:
inclusion criteria: * willing to give written informed consent, make the required study visits and follow instructions; * the study eye: * must have a primary diagnosis of choroidal neovascularization (cnv) secondary to amd; * lesion must be no larger than 30 mm2; * must have edema measuring greater than 340 μm; * must have a visual score between 73 and 34 letters, inclusive; * must be able to have clear picture taken of the back of the eye; * other protocol-defined inclusion criteria may apply. exclusion criteria: * the study eye must not have been treated for exudative amd previously; * the study eye must not have any other ocular disease, condition, infection, or recent surgery that would interfere with vision or examination of the back of the eye; * the study eye must not have uncontrolled glaucoma; * the study eye must not be missing a lens; * must not be taking any medication that is toxic to the lens; * must not be taking oral or ocular corticosteroids; * must not have an unstable or progressive condition that would interfere with study visits; * must not have allergies to any component of the test article or sensitivity to fluorescein dye; * if female, must not be pregnant or nursing and must agree to adequate birth control; * must not be participating in another drug or device study within 30 days of screening for this study; * other protocol-defined exclusion criteria may apply.

Keywords: wet age-related macular degeneration, exudative
advanced analysis of the carotid phonoangiography and diseases

Conditions: Carotid Atherosclerosis; Seeing Sounds as Colors; Stenosis; Stroke

Summary: purpose: to investigate the different sound spectrum of carotid arteries and to analyze its relationship to the vessel disease, and to build a new biomarker about vascular disorder. methods: to record the carotid phonoangiography with digital stereoscopy and analysis the spectrum with different algorithm such as fft, wavelet, entropy, complexity, and hht. the results will be correlated and comparison to the finding in clinical, carotid doppler and duplex, cta, mr, and catheter angiography. statistics: the significance of difference between parameters was computed using t-tests or paired t-test etc. a p value \<0.05 is defined as significant.

the investigators plan to recruit data from patients that come to their department for angiography study and intervention (n=300) with different disease entity such as atherosclerosis, tumor, aneurysm, arteriovenous malformation or fistula, and other vascular disorders. a period of about 20 seconds of the carotid phonoangiography was recorded. standard for comparison: catheter angiography, cta, mri/mra. the degree of stenosis, the wall thickness, si and density change was clustered and compared. the clinical and laboratory data will be reviewed and the vascular risk factors will be calculated. spectrum analysis: the sound spectrum will be analysis with the fft, wavelet, entropy, complexity, and hht algorithms. the correlation between change of spectrums and also the correlated clinical, images, and laboratory change will be further analysis by statistic method.

Eligibility criteria:
inclusion criteria: 1. age: 20 years old to 99 years old 2. gender: unlimited 3. because different types of brain diseases, those who received conventional catheter vascular examination. exclusion criteria: 1. neck inflammation locally who can not admit the sound. 2. due to inability to cooperate to accept those recordings.

Keywords: carotid artery sound stenosis wall stroke
telerehabilitation to improve balance and mobility in patients after stroke

Conditions: Hemorrhagic Stroke; Ischemic Stroke

Summary: telerehabilitation is an effective rehabilitation method that allows patients to receive physiotherapy remotely in their homes. the purpose of this study was to investigate the effects of home-based remote group training for balance and mobility on activities and body functions.

patients in the chronic post-stroke phase will be assessed for balance and mobility before and after remotely conducted group training. the training will last for 6 weeks, with two 60-minute sessions of balance and mobility training per week. two consecutive groups will participate. the participants's balance and weight-bearing symmetry will be comprehensive assessed, as well their sit-to-stand ability, walking speed, and satisfaction with the remote training. detailed inclusion and exclusion criteria are specified in the appropriate section.

Eligibility criteria:
inclusion criteria: * chronic phase of ischemic or haemorrhagic stroke (\>6 months after stroke) * ability to walk independently on level ground or on all surfaces with or without a walking aid * mild balance deficit * sufficient cognitive and communicative abilities for participation * access to a personal computer with a camera, connected to the internet exclusion criteria: * stroke in the brainstem or cerebellum * additional neurological condition * musculoskeletal impairments that would interfere with the training * advanced heart failure

Keywords: stroke telerehabilitation balance mobility
prediction of recurrence and complications of nephrolithiasis using a precision medicine approach

Conditions: Kidney Stone; Nephrolithiasis

Summary: nephrolithiasis is a disease caused by the formation of kidney stones in the urinary tract which can then partially or completely obstruct the latter causing an extremely sharp pain called renal colic. in industrialized countries, it affects 10 to 20% of the population, and is the most common kidney disease.the primary objective of this study is to identify the clinical, biological, genetic, molecular and environmental determinants predictive of recurrence of renal lithiasis. the study follow-up visit schedule corresponds to the visits usually scheduled as part of patient care: 1 year from the inclusion visit (a1), 3 years (a3) then 5 years (a5). samples for research (additional volume of blood, urine) will be taken by a registered nurse along with the routine check-up samples.samples intended for research will be sent by staff to the biobanque de picardie (chu amiens-picardie) for processing and conservation.


Eligibility criteria:
inclusion criteria: * adults (≥18 years old), male or female , * persons able to understand and object to the information provided (at the discretion of the investigator) * patient affiliated to social security * patient agreeing to sign the informed consent form * patient having presented at least one renal colic attack before inclusion exclusion criteria: * pregnant or breastfeeding woman. * persons deprived of liberty, * adults under legal protection guardianship, or curators or unable to express their consent. * patient refusing to participate in the study * patient in an emergency situation

Keywords: kidney stone nephrolithiasis
real world safety & efficacy experience of empagliflozin with or without metformin in t2dm patients - ease study

Conditions: Type II Diabetes Mellitus; Efficacy, Self; Safety Issues

Summary: study objective to evaluate the safety and tolerability of empagliflozin with or without metformin in patients with type ii diabetes mellitus in the pakistani population. study design open-label, prospective, observational, single arm, multi-center, post-marketing surveillance study. sample size the estimated sample size will be n=156. duration of study 12 months (data lock point will be completion of 6 months' follow-up from the time of last patient's enrollment date) safety assessment: patient will be monitored for hypoglycemia, dehydration, hypotension, urinary tract infections, fungal infections, nausea, vomiting, diarrhea, abdominal discomfort, flatulence, asthenia, indigestion and other side effects (if any). follow up visits: after recruitment, patient is supposed to have three visits for follow-ups. visit 1: 4 to 6 weeks of initiation of therapy. visit 02: at 12 weeks of initiation of therapy. visit 03: at 24 weeks of initiation of therapy. laboratory testing: reputable lab is considered for laboratory testing of diabetes patients i.e. hba1c%, fbg, rft and urine r/e. the certified clinical lab will be responsible for receiving and analyzing clinical sample. patients will have special discount of upto 50% for study related laboratory investigations. where in urine routine examination (urine r/e), we consider as follows: * visual examination: * urine color: normal (yellow), pale yellow, dark yellow, brown, red or pink or any other. * urine clarity: clear, slightly cloudy, cloudy or turbidity * chemical examination: * specific gravity * ph * bilirubin * urobilinogen * protein * ketone * leukocyte esterase * microscopic examination: * red blood cells: * epithelial cells: * amorphous: * pus cells * bacteria * yeast * casts * crystals where in renal function test (rft), we consider as follows: * blood urea nitrogen (bun): mg/dl * serum creatinine: mg/dl * estimated glomerular filtration rate (egfr): ml/min/1.73 m2


Eligibility criteria:
inclusion criteria: patient with t2dm between 18 to 65 years with hba1c 7% - 10%, who can give informed consent. patient uncontrolled on oral antidiabetics and lifestyle modification for at least 3 months. patient who are empagliflozin naive. egfr ˃60 ml/min/1.73m2. exclusion criteria: type 1 diabetes, history of recurrent urinary tract infection (uti), fungal infection, renal and/or hepatic dysfunctions, where rft and urine r/e is abnormal, diabetic ketoacidosis and/or hyperosmolar hyperglycemic state, severe hypoglycemia, pregnant or lactating women, pancreatitis, any serious complications or hypersensitivity.
how dose election event will induce emotion change of emergency room and critical unit

Conditions: Emotional Problem

Summary: in response to the emergence of injuries and illnesses, the manpower of the acute and critical medical team has the requirements. the election keen is rare to see in recent years. the results of the election event will inevitably bring to the emergency and critical unit nursing staff and on-site counter personnel. certain emotional changes is noted and this study is to understand the impact of the emotional adjustment of personnel in acute and critical units on their own work, to understand the situation of on-site personnel, and to avoid excessive planning of manpower, which will help hospital manpower deployment i

in 20181124, the mayor of the county and the 2020 president election, after the election, the mood changes of the nursing staff of the emergency and critical unit and the staff of the on-site counter medical department were filled out with a questionnaire to understand the mood changes of the nursing staff and on-site counter staff in each unit and how to adjust analysis of the impact on clinical work. exclude those who complete the questionnaire data incompletely, the statistical method used is to calculate the cronbach's α and correlation coefficient for the questionnaire sample verification.

Eligibility criteria:
inclusion criteria: * nursing manpower in emergency and critical unit exclusion criteria: * incomplete questionnaire filled in

Keywords: emotional change emotional labor emotional control