Kornimate/medical-research-clean huggingface dataset:
intravenous vitamin c in combination with standard chemotherapy for pancreatic cancer

Conditions: Metastatic Pancreatic Cancer

Summary: eligible candidates will be adults with metastatic pancreatic cancer (confirmed diagnosis with pathology reports and measurable computed tomography (ct) or magnetic resonance imaging (mri)). participants must not be receiving any other concurrent chemotherapy, or radiation therapy. full inclusion/exclusion criteria are available. history and physical examination, and laboratory and imaging analyses will be done within 14 days prior to registration. the three cohorts of subjects will receive 50, 75 or 100 grams of intravenous ascorbic acid, three times per week for 8 weeks. subjects will also have co-administration of the chemotherapy medications, gemcitabine (intravenously) and erlotinib (orally). approximately 9 to 18 participants will be enrolled in this phase i study.


Eligibility criteria:
inclusion criteria: * metastatic pancreatic cancer * glucose 6 phosphate dehydrogenase status normal * ecog performance status 0-2 * normal creatinine and transaminase * women of child-bearing potential confirm negative pregnancy test exclusion criteria: * concurrent chemotherapy or radiotherapy * significant co-morbid disorders * significant psychiatric symptoms * prior treatment with gemcitabine * concurrent chronic use of immunosuppressive agents (methotrexate, cyclosporine,corticosteroids) * regular use of nonsteroidal anti-inflammatory agents * smoking more than 1 pack per day * excessive alcohol or drug use * enrollment in other experimental therapy * active infection * patients experiencing ongoing response to recent treatments

Keywords: pancreatic cancer
hrqol in the low meld pre-tx population

Conditions: Cirrhosis of the Liver

Summary: the purpose of this study is to describe the hrqol in those with meld scores \</= 15 in a single center for those who are pre-liver transplant candidates

the liver organ allocation system was significantly revised in 2002, allowing a more objective prioritization of liver transplant candidates. the revised model for end stage liver disease (meld) system is based primarily on laboratory test results. candidates with meld scores of less than 15 are considered to be low priority for cadaveric liver transplant and have limited treatment options. yet patients with low meld scores may suffer from an array of symptoms associated with liver disease such as fatigue, sleep disturbances, and depression - all of which erode health-related quality of life (hrqol). no previous studies were found that examined hrqol in low meld transplant patients. a better understanding of the hrqol of these patients will allow clinicians to better meet their needs. therefore, the aims of the proposed pilot capstone project are to examine hrqol and to identify demographic and clinical characteristics including liver-disease related symptoms, functional status, perceived social support, biological functioning and mental health associated with hrqol in pre-liver transplant candidates with low meld scores. the revised wilson and cleary quality of life model will be used to guide the project. fifty pre-transplant liver candidates with meld scores \< 15 will be enrolled in the descriptive, cross-sectional pilot study. participants will complete a written questionnaire measuring perceived hrqol and clinical characteristics. descriptive and correlational statistics will be used to analyze the data. findings from this project will identify trends in factors that contribute to a hrqol of this population and provide the foundation for a larger future project.

Eligibility criteria:
inclusion criteria: 1. must be a patient in the liver transplant clinic at northwestern memorial hospital or one of its satellite clinics (including washington, illinois; portage, indiana; glenview, illinois, oakbrook, illinois; joliet, illinois) 2. adult patient between the ages of 18-75 3. ability to read and speak english 4. must be a candidate for liver transplant per northwestern memorial hospital liver transplant multidisciplinary committee 5. model for end stage liver disease (meld) score ≤15 6. cognitive ability to complete measures exclusion criteria: 1. non-english speaking 2. those who have already received a liver transplant 3. hepatic encephalopathy as evidenced by: 1. grade ii or more west haven criteria or adapted west haven criteria 2. evidence of asterixis upon exam at time of consent (if consented in person) 4. acute liver failure as etiology for liver disease. 5. meld score \> 15 6. mental retardation or cognitive disabilities preventing completion of the written questionnaire

Keywords: cirrhosis of the liver pre-liver transplant candidate depression poor social support liver disease symptoms health releated quality of life
movida 1 ter - evaluation of the cobas® plasma separation card in the field in vietnam

Conditions: HIV Infections

Summary: in low- and middle-income countries, viral load (vl) monitoring of patients living with hiv and followed on antiretroviral therapy (art) in remote settings is still scarce. barriers to vl monitoring are essentially the limited access to a laboratory able to perform this measurement, its cost, as well as the lack of human and material resources. blood sampling using dried blood spots (dbs), which has been validated and is immediately available, could overcome these barriers. with dbs, transfer and conservation of samples are simplified enabling access to vl monitoring to patients seeking care in sites far from laboratory facilities. use of dbs also offers the advantage not to require extensive investments. to guide decision makers in the implementation of strategies to scale-up hiv vl monitoring in remote settings, field evaluations of dbs in routine conditions are needed. it is in this context that we propose this field evaluation of the cobas® plasma separation card in vietnam

in vietnam, in 2018, hiv prevalence was estimated at 0.3% among adults and the estimated proportion of plhiv on art was 65%, however the hiv epidemic is essentially concentrated in people who inject drugs, men who have sex with men and sex workers. as of today, routine hiv vl monitoring is not yet available in remote settings in vietnam. despite an initiative we conducted and that documented the feasibility of dbs use in remote settings, and although no genuine roll-out of poc machines is yet observed in the field, the ministry of health of vietnam has not yet decided to scale-up hiv vl monitoring using dbs. more field evaluations are needed to convince the ministry of health that dbs can effectively be used to scale-up hiv vl monitoring. the aim of the present study is to evaluate the sensitivity and specificity of hiv vl measurement using the cobas® plasma separation card (psc) against plasma at the threshold of 1000 copies/ml (threshold currently used to define failure in vietnam, following the who guidelines).

Eligibility criteria:
inclusion criteria: * ≥18 years of age * hiv-1 infected adults * willing to participate to the study by giving his/her consent exclusion criteria: * none

Keywords: viral load monitoring, dried blood spot
effect of selenium intervention on inflammation in older adults

Conditions: Inflammation

Summary: serum levels of inflammatory mediators increase with age and are strongly associated with the most common and the most devastating health conditions found in older adults including frailty, chronic disease, disability and increased mortality. even though the processes that contribute to increased inflammatory mediators are likely not completely reversible in older adults, the development of a safe and effective intervention that modulates inappropriate inflammatory responses could be a very important component of prevention against frailty and other adverse health outcomes. as part of an ongoing effort to identify molecular and physiologic triggers of inflammation in older adults, the investigators recently identified a highly significant inverse relationship between the anti-oxidant micronutrient selenium and the inflammatory mediator il-6, as well as a significant relationship between selenium and all cause mortality in a population of community dwelling older women with selenium levels well below the mean for the overall american population. based on our findings in older adults and on data from other studies that suggest that selenium interventions are effective in targeted populations with inflammatory conditions, the investigators hypothesize that selenium supplementation targeted to a population of older adults with increased inflammatory markers and low normal selenium levels will in the short term reduce inflammation as measured by serum il-6, and in the long term will reduce the incidence and prevalence of inflammation associated poor health outcomes of frailty, disability, and mortality in vulnerable older adults.


Eligibility criteria:
inclusion criteria: * 70 years of age or older * able to provide written informed consent for screening and participation in the study exclusion criteria: * taking a multi-vitamin containing 60 ug or more of selenium more than once a week * have evidence of an active, untreated, acute inflammatory disease state such as rheumatoid arthritis, gout, or malignancy * taking any corticosteroids or the medications prednisone or methotrexate

Keywords: dietary supplement selenium healthy volunteer johns hopkins older aging geriatrics baltimore mineral over 70
effect of ramosetron on heart rate-corrected qt interval during robot-assisted laparoscopic prostatectomy with steep trendelenburg position

Conditions: Prostate Cancer

Summary: intraperitoneal insufflation of carbon dioxide may affect the sympathetic activity that leads to changes in ventricular re-polarization. this in turn can result in changes of heart rate-corrected qt (qtc) interval. ramosetron is a 5-hydroxytryptamine three receptor antagonist and widely used anti-emetics. however, qtc interval prolongation has been observed in a number of patients after administration of 5-ht3 receptor antagonists. the aim of this study is to evaluate the effects of ramosetron on qtc interval and possible cardiovascular adverse effects during robot-assisted laparoscopic prostatectomy with steep trendelenburg position.

intraperitoneal insufflation of carbon dioxide may affect the sympathetic activity that leads to changes in ventricular re-polarization. this in turn can result in changes of heart rate-corrected qt (qtc) interval. ramosetron is a 5-hydroxytryptamine three receptor antagonist and widely used anti-emetics. however, qtc interval prolongation has been observed in a number of patients after administration of 5-ht3 receptor antagonists. the aim of this study is to evaluate the effects of ramosetron on qtc interval and possible cardiovascular adverse effects during robot-assisted laparoscopic prostatectomy with steep trendelenburg position. fifty-six patients, aged more than 19 years, undergoing robot-assisted laparoscopic prostatectomy will be divided into ramosetron group (n=28) and control group (n=28). randomly selected patients of the ramoseton group are given a 0.3 mg of ramosetron after induction. in contrast, patients in the control group are given the same volume of normal saline after induction and given a 0.3 mg of ramosetron after measurement of qtc interval. the primary endpoint is the difference in maximal change of qtc interval between groups.

Eligibility criteria:
inclusion criteria: * patients undergoing robot-assisted laparoscopic prostatectomy * age more than 19 years exclusion criteria: * preoperative electrocardiography (ecg) abnormalities, including a qtc interval of \>500 ms, ventricular conduction abnormalities, or arrhythmias * history of cardiac disease such as pacemaker insertion, unstable angina * use of antiarrhythmic agents or medications that are known to prolong the qtc interval * abnormal levels of preoperative serum electrolyte
family history in prostate cancer patients in taiwan

Conditions: Prostate Cancer

Summary: to investigate the prevalence of family history in prostate cancer patients in taiwan and evaluate the association of variation of diseases and family history

we retrospectively reviewed the medical charts of prostate cancer patients at ntuh from 1978 to 2002. the initial presentations, systemic diseases, smoking habits, clinical stages, gleason scores, pathological stages, treatments, and outcome were recorded. post-hoc questionnaires were completed with opd visits, admission visits, telephone interviews and mails. the questionnaires included the family histories of prostate cancer, colon cancer, breast cancer, hepatoma and so on. if patients is passed away, the first degree relatives will fill the vacant position. the prevalence of family histories of prostate cancers in these patients was determined. the associations of family histories and clinical presentations were analyzed. besides, the characteristics of patients with and without responses were discussed.

Eligibility criteria:
inclusion criteria: * prostate cancer patients who were recorded at national taiwan university hospital from 1977 to 2002. exclusion criteria: * patients or their family who refused our contact or were unable to be contacted

Keywords: prostatic neoplasms family history
descriptive study of mental activity

Conditions: Psychiatric Disorder Requiring Hospitalization

Summary: provide a description of patients admitted in the psychaitric department of the mayotte hospital

this feature and the proximity of mayotte with developing countries give this department different specificities, both culturally and medically. indeed, the local population of lifestyle and specific beliefs, combining islam and animism. thus, a person with mental suffering is traditionally treated by a wizard who will come into contact with the spirits that inhabit the person, the community that supports the patient remains at home. mayotte is far behind compared to the metropolis where the supply of psychiatric care with a fragile population, a care network being created, and few downstream solutions to handle crisis situations, emergency unit and psychiatric liaison, speaking to general emergencies was established in 2010. it is currently the only access to emergency psychiatric care on the island. the situations covered by this unit are for patients of all ages and all social and geographical origins, reflecting the demographics of the population. investigator has only quantitative data (number of patients / year) and has no qualitative analysis tool. no epidemiological research has been done to date in this direction. the aim of our study was to analyze the impact of various psychiatric disorders represented mayotte of the emergency hospital to get a statistical picture of its business. this description will present to the scientific community the specifics of this department

Eligibility criteria:
inclusion criteria: patient in need of psychiatric care in the emergency department exclusion criteria: * patient leaves the emergency department against medical advice or fugue * patient leaves the service without the medical diagnosis is made * patient in exclusion period determined by a previous search * patients for whom it is impossible give clear information * patient who manifested their opposition to participate in research * patient minor whose parental agreement has been reached * patient on safeguarding justice whose guardian will not be contacted
two therapeutic strategies for the maintenance of remission in patients with ulcerative colitis

Conditions: Colitis, Ulcerative

Summary: ulcerative colitis patients treated with infliximab (ifx) in deep remission after at least 12 months of treatment will be randomized to continue ifx or to stop ifx and start azathioprine (aza). each patient will be followed for 12 months.

all eligible subjects will be able to participate in the study at any infusion occurred after 12 months since the beginning. they will be screened by medical history, physical examination, blood and faecal tests (included c-reactive protein and faecal calprotectin), as required by clinical practice. no children, pregnant or breastfeeding women, or elder subjects will be included. a colonoscopy + biopsies in the area of greater inflammation will be performed within ± 3 weeks since the baseline visit. the subjects can then be randomized and receive their first dose of study medication. subjects will be then evaluated every 8 weeks for the following 12 months from the randomization. clinical and blood tests will be performed, and the partial mayo score will be calculated at each visit, until the final visit, when a new colonoscopy with biopsies will be repeated and the global mayo score will be evaluated. at final visit a new faecal sample for calprotectin will be collected. safety of the study treatments will be evaluated at each study visit. in case of study agent discontinuation, the patient will be managed according to usual practice and followed for the entire study period. patients randomized in aza arm, could restart ifx.

Eligibility criteria:
inclusion criteria: * age 18 -65 years * written informed consent and willing to adhere to study procedures. * therapy with infliximab since at least 12 months, with one infusion every 8 weeks (a maximum interval between two infusions of ± 3 weeks is allowed) * sustained steroid-free remission in the last 6 months prior to inclusion, except for use of steroids as a preventive measure for infliximab infusion reaction, if required by local guidelines. * global mayo score at baseline ≤ 2 * all mayo subscores ≤ 1 * absence of rectal bleeding * effective methods to avoid pregnancy during the study period exclusion criteria: * disabling and persisting extraintestinal manifestation at baseline * patients unable to comply with study procedures * known intolerance or previous allergic reaction to thiopurines * concomitant therapy with allopurinol * any disease not compatible with the use of infliximab or azathioprine, as per clinician's judgement. * need for dose escalation of infliximab in the last 12 months prior to baseline. * white blood cell count \< 3000/mmc or absolute clinically relevant lymphopenia at baseline * active pregnancy or breastfeeding; willing for pregnancy during the study period
evaluating and establishing the relationship in the five critical x-ray time points in spinal deformity realignment

Conditions: Spine; Spine Deformity

Summary: to establish the relationship in the five critical x-ray time points during multilevel posterior column osteotomies (mpco) spinal deformity realignment in patients with adult spinal deformity and to follow the participants longitudinally to examine any follow-up x-rays and clinical data to compare to the post-operative standing scan and pre-operative data.

studies in adult spinal deformity (asd) have found that the presence of sagittal imbalance directly correlates with worsening quality of life. multilevel posterior column osteotomies (mpcos) is a technique that can provide correction to adult spinal deformity. mpcos can be utilized for revision surgery as an alternative to 3-column osteotomies and have the ability to aggregate large amount of lordosis segmentally. the success of the mpco technique largely depends on radiographs taken during these surgeries to aid the surgeon in establishing the best screw and rod placement and making intraoperative adjustments. imaging plays a vital role in evaluating hardware positioning and assessing hardware integrity as well as evaluating potential complication. the investigator plans to evaluate and establish the relationship in the five critical x-ray time points (preoperative standing and supine, intraoperative pre- and post-correction, and postoperative standing films) during mpco spinal deformity realignment and measure pre- to post-operative outcome longitudinally. the investigator will investigate lumbar lordosis and sagittal and coronal alignment at those 5 time points and examine the relationship between pre-op, intra-op, and post-op images to understand impact of the mpco technique and examine expected outcome to final outcome. additionally, if the o-arm 2d long film scanner is utilized during the surgery, the investigator will analyze that film and compare it to the other x-rays taken.

Eligibility criteria:
inclusion criteria: * surgical candidate for posterior only surgery for adult spinal deformity * patients must require deformity correction greater than 3 levels * adults between the ages of 18-80 * decisional capacity to consent to the study * both primary and revision surgeries will be included exclusion criteria: * 1) not meeting candidacy for posterior spine surgery
red cell distribution width and lactate albumin ratio as prognostic markers for mortality in sepsis and septic shock

Conditions: Morality; Sepsis; Septic Shock

Summary: the aim of this study is to find the utility of red cell distribution width and lactate/albumin ratio as prognostic markers in sepsis and septic shock patients.

several indicators are being used to predict the prognosis of sepsis. commonly used prognostic indicators include acute physiological and chronic health evaluation ii (apache ii), sequential organ failure assessment (sofa), mortality in emergency department score (meds), new york sepsis severity score. red cell distribution width and lactate albumin ratio are being investigated for there prognostic value in septic patients.

Eligibility criteria:
inclusion criteria: 1. age from 18 to 60 years old. 2. clinical criteria of sepsis 3. or clinical criteria of septic shock including sepsis with persisting hypotension requiring vasopressors to maintain mean arterial pressure \> 65 mmhg and having a serum lactate level \> 2 mmol/l despite adequate volume resuscitation. exclusion criteria: 1. no informed consent. 2. patient with incomplete information and data. 3. the patient who received blood transfusion within 90 days before emergency admission. 4. the patients who are known to have long-term conditions causing anemia like sickle cell anemia, thalassemia, iron deficiency anemia. 5. malignancy and chemotherapy during the previous 90 days. 6. patients with either hepatic dysfunction, renal failure, having any disease in which albumin should be supplemented as liver cirrhosis with ascites, nephrotic syndrome and burns.
a study of the hsp90 inhibitor, sta-9090 in subjects with stage iiib or iv non-small cell lung cancer (nsclc)

Conditions: Non Small Cell Lung Cancer

Summary: this is a phase 2 study of the hsp90 inhibitor, sta-9090 (ganetespib) in subjects with stage iiib or iv non-small cell lung cancer (nsclc).


Eligibility criteria:
inclusion criteria: * pathologically confirmed diagnosis of stage iiib (with pleural effusion) or stage iv nsclc with measurable disease by recist and evidence of progression * availability of tissue for analysis * ecog performance status 0 or 1 * adequate organ function as defined in the protocol. * must be at least 18 years old and able and willing to sign a written informed consent document exclusion criteria: * poor venous access requiring an indwelling catheter for study drug administration * women who are pregnant or lactating * ventricular ejection fraction \< or = to 55% at baseline * any uncontrolled intercurrent illness

Keywords: synta sta 9090 ganetespib) lung cancer non small cell lung cancer nsclc