Kornimate/medical-research-clean huggingface dataset:
nephrogenic systemic fibrosis (nsf): analysis of tissue gadolinium levels

Conditions: Nephrogenic Systemic Fibrosis; Nephrogenic Fibrosing Dermopathy

Summary: the primary objective of this study is to determine any causative or associated factors for the development of nephrogenic systemic fibrosis (nsf), nephrogenic fibrosing dermopathy (nfd), or related diagnosis. our primary focus will be on the previous administration of gadolinium to these patients, but we will also look at other postulated causes and risk factors. the secondary objective of this study is to assess tissue gadolinium (gd) levels in five groups of subjects: * those affected by nsf. * those with normal kidney function who have undergone a medical imaging procedure using gd-based contrast agent (gbca) in the 2 years prior to a skin biopsy. * those with normal kidney function who have never been exposed to gbca and have had a skin biopsy. * those on dialysis or with egfr ≤ 30 ml/min/1.73 m2 who have had a medical imaging procedure using gbca in the 2 years prior to skin biopsy. * those on dialysis or with egfr ≤ 30 ml/min/1.73 m2 who have never been exposed to gbca and have had skin biopsy. we hypothesize that there is a correlation between the administration of gd-containing agents usually associated with mri procedures and the development of nsf in those with renal failure and some other predisposing condition. we also hypothesize that tissue gd levels in those with nsf will be higher than in those who have been exposed to gbca but do not have nsf. of the two groups without nsf but with exposure to gbca, we hypothesize that those with kidney dysfunction will have higher tissue gd levels than those with normal kidney function. we hypothesize that in the two groups of subjects without exposure to gbca, there will be no detectable levels of gd, regardless of kidney function status.


Eligibility criteria:
nsf group inclusion criteria: * biopsy-confirmed diagnosis of nsf exclusion criteria: * does not have nsf normal renal plus gadolinium exposure inclusion criteria: * egfr \>30 * existing skin tissue sample * gadolinium exposure in 2 years preceding skin biopsy exclusion criteria: * does not fit inclusion criteria abnormal renal plus gadolinium exposure inclusion criteria: * egfr \<30 or on dialysis * existing skin tissue sample * gadolinium exposure in 2 years preceding skin biopsy exclusion criteria: * does not fit inclusion criteria abnormal renal without gadolinium exposure inclusion criteria: * egfr \<30 or on dialysis * existing skin tissue sample * no gadolinium exposure ever exclusion criteria: * does not fit inclusion criteria normal renal without gadolinium exposure inclusion criteria: * egfr \>30 * existing skin tissue sample * no gadolinium exposure ever exclusion criteria: * does not fit inclusion criteria controls (neonatal) inclusion criteria: * existing skin biopsy tissue that was performed within the first 6 months of life exclusion criteria: * does not fit inclusion criteria
the effect of whole body vibration after aclr

Conditions: ACL Injury

Summary: this is a randomised clinical trial to detect the effect of an 8-week whole body vibration training on muscle function and dynamic knee function during single leg squat and single leg hop in patients after anterior cruciate ligament reconstruction

in hong kong, over 3000 cases of acl reconstruction are operated annually to restore knee stability. despite recovery of knee passive laxity and muscle strength, dynamic knee stability is often not restored. the whole body vibration has been found to improve muscle strength, proprioception and balance after acl reconstruction. this project will investigate the effect of whole body vibration on muscle elasticity, muscle coordination and landing knee biomechanics. it may provide useful evidence to the application of whole body vibration in improving dynamic knee stability, which will lead to a significant improvement in healthcare management for acl patients . the current study serves to provide a clinical guideline for post-acl reconstruction rehabilitation.

Eligibility criteria:
inclusion criteria: 1. aged 18-50; 2. physically active before injury with tegner score more than 6 (recreational/professional sport level); 3. scheduled for aclr because of sport injury; 4. be able to walk with a pair of elbow crutches independently at 1 month after aclr. exclusion criteria: 1. concomitant posterior cruciate ligament or lateral collateral ligament injury in the same knee; 2. injury to the contralateral side; 3. medical problems that are contradictory to wbv; 4. prior experience of wbv to avoid any training or memory effect; 5. women with pregnancy.

Keywords: acl dynamic knee stability whole body vibration
gut link: a study of a care pathway across primary and gi specialty care

Conditions: Irritable Bowel Syndrome; GI Disorders

Summary: it can be challenging for primary healthcare providers (phcps) to differentiate between ibs and more serious illnesses involving the gi tract, such as crohn's disease, ulcerative colitis, or cancer. to help with diagnosis and treatment of ibs, evidence-based guidelines have been developed. however, they are not commonly used in primary care practice and phcps and patients often feel that gi specialist evaluation and endoscopy is required. the development of care pathways and clinical practice guidelines is essential to support the investigation and management of digestive diseases, such as ibs. the current pilot study is designed to assess the implementation and early comparative effectiveness of a clinical care pathway for lower gi tract symptoms.


Eligibility criteria:
inclusion criteria: * must be a general practitioner * have a family practice in nova scotia, canada * utilize the platform 'virtual hallway' as part of current referral practices * deliver care to patients with lower gi complaints exclusion criteria: * none

Keywords: care pathway care delivery virtual
residual neuromuscular block in the post-anesthetic unit and postoperative complications

Conditions: Postoperative Neuromuscular Block; Postoperative Complications

Summary: the use of neuromuscular blockers (nmb) is essential to optimize surgical conditions, ensure patient immobility during the intervention and prevent complications derived from involuntary movements. intraoperative monitoring of neuromuscular relaxation allows the depth of neuromuscular blockade to be accurately evaluated, guaranteeing ideal conditions for the surgical team. residual neuromuscular blockade (rnmb) is the persistence of muscle paralysis after the administration of nmb during a surgical intervention. the appearance of rnmb poses substantial challenges in the postoperative period, as it has negative repercussions for the safety and well-being of the patient.

the use of neuromuscular blockers (nmb) is essential to optimize surgical conditions, ensure patient immobility during the intervention and prevent complications derived from involuntary movements. intraoperative monitoring of neuromuscular relaxation allows the depth of neuromuscular blockade to be accurately evaluated, guaranteeing ideal conditions for the surgical team. residual neuromuscular blockade (rnmb) is the persistence of muscle paralysis after the administration of nmb during a surgical intervention. the appearance of rnmb poses substantial challenges in the postoperative period, as it has negative repercussions for the safety and well-being of the patient. in this prospective observational study, all patients who underwent general anesthesia with neuromuscular blockade were studied consecutively for one month to evaluate the presence of residual neuromuscular blockade and its potential consequences during hospital admission. .

Eligibility criteria:
inclusion criteria: * patient undergoing surgical intervention under general anesthesia that requires the use of neuromuscular block during the study time and that required hospital admission. * informed consent signature. exclusion criteria: * neuromuscular disease * not having received neuromuscular block during the intervention * admission to the outpatient surgery unit * admission to the postoperative intensive care unit * patients who signed informed consent, but postoperative data could not be collected upon arrival at the pacu.

Keywords: general anesthesia neuromuscular block
anti-nucleosome b lymphocytes in lupus

Conditions: Systemic Lupus Erythematosus With or Without Clinical Activity

Summary: lupus disease is characterized by the production of pathogenic autoantibodies, which participate in end-organ damages. the phenotype of b cells producing the pathogenic autoantibodies in lupus patients is today unknown. antinucleosome antibodies are characteristic of lupus disease.this project proposes to detect antinucleosome b cells in lupus patients and to analyse their phenotype and their frequency.


Eligibility criteria:
inclusion criteria for sle patients: sle patient : diagnostic based on acr criteria * sle patient producing seric anti-nucleosome antibodies (elisa) * sledai-2k activity score : inferior to 5 for quiescent patients, superior to 8 since at least 2 months for active patients exclusion criteria for sle patients: -- other autoimmune diseases than sle- induced lupus * treatment with corticosteroids \>10mg/d (prednisone) for quiescent patients * treatment with corticosteroids \>20mg/d (prednisone) for active patients * oral immunosuppressive treatment during the last 6 months (methotrexate, azathioprine, ciclosporine, mycophénolate mofétil) for all patients, treatment during the last year with cyclophosphamide or monoclonal antibodies (rituximab, belimumab) for pour quiescent patients * disease which can modify b and t lymphocyte functions: primary immune deficiencies, evolutive infections, chronic viral infection (vih in particular), chemotherapy or neoplasm antecedent
health dialogues for patients with mental illness in primary care

Conditions: Mental Illness; Stress; Fatigue; Sleep Disorder; Depression; Diabetes; Myocardial Disease; Stroke; Death

Summary: in the current project, primary health care patients with mental illness such as anxiety, depression, fatigue or sleep disorders will be followed. the study includes both health conversations with the health curve as a systematic work with lifestyle habits, and the biochemical risk marker copeptin with a focus on improved lifestyle habits and the development of cardiovascular complications. participants will be followed up at 12 and 24 months with renewed health interview including the health curve and blood sampling. national registries will be used for a, up to 20 year long follow-up regarding cardiovascular complications and mortality.

patients with mental illness have an increased risk of cardiovascular morbidity and mortality compared to the rest of the population, partly related to unhealthy lifestyle habits. however, not all risk factors for developing cardiovascular disease are known yet. the interest in studies about the importance of copeptin as a biochemical risk factors has increased in recent years. objectives: the main aim with this project is assessment of the effect of health dialogue with the health curve (in swedish; hälsokurvan) on lifestyle habits and cardiovascular risk factors in patients with mental illness in primary care. the second aim is to assess copeptin's prognostic value and to collect blood samples in a biobank for future research on molecular biomarkers with prognostic value for cardiovascular disease. work plan: the study has a prospective observational design. the method with health dialogues is previously validated in a swedish context and is based on a detailed lifestyle questionnaire, blood testing and personalized counselling by a trained health care professional. the patients will be followed with a new health dialogue and blood samples after 12 and 24 months and for 20 years with national registers significance: the effect of health dialogues in patients with mental illness is not studied yet. the current fast implementation of the method in the primary care in south of sweden (the region of scania) provides a unique opportunity to study this patient group and the expected benefits of health dialogues in the long term, to study a potentially useful risk biomarker (copeptin) as well as to build a biobank for future studies on cardiovascular prognostic risk markers.

Eligibility criteria:
inclusion criteria: * patients \> 18 years old seeking primary care for mental illness (depression, anxiety, sleep disorders or stress related problems exclusion criteria: * dementia, not speaking, writing or understanding spoken the swedish language.

Keywords: primary health care health dialogue long-term follow-up mental illness
phase i/ii study of retroviral-mediated transfer of iduronate-2-sulfatase gene into lymphocytes of patients with mucopolysaccharidosis ii (mild hunter syndrome)

Conditions: Mucopolysaccharidosis II

Summary: objectives: i. evaluate the safety and feasibility of treating mucopolysaccharidosis ii (mild hunter syndrome) by lymphocyte gene therapy. ii. determine the levels of iduronate-2-sulfatase enzyme in these patients attained by infusing increasing doses of lymphocytes transduced with a retroviral vector designed for insertion and expression of this iduronate-2-sulfatase gene (l2sn). iii. determine the duration of survival of these transduced cells in these patients. iv. determine whether monthly infusion of l2sn-transduced lymphocytes accomplishes metabolic correction (as measured by glycosaminoglycan excretion), decrease in liver or spleen volume, any therapeutic effect upon cardiac and pulmonary dysfunction, or any other effects from treatment.

protocol outline: peripheral blood lymphocytes are harvested from patient by apheresis, stimulated to initiate the growth of t-lymphocytes, transduced with retrovirus l2sn containing iduronate-2-sulfatase, and reinfused into the patient. patients receive 12 monthly infusions of these retroviral-mediated gene transduced lymphocytes with the first three infusions in a dose escalation format. patients are monitored for at least 2 hours after completion of each infusion. patients are followed at 1 year after treatment, and then until death.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- mucopolysaccharidosis ii (mild hunter syndrome) as defined by the following: * characteristic coarse facial features, hepatosplenomegaly, and radiographic evidence of dysostosis multiplex * elevated urinary excretion of glycosaminoglycans in 3 urine specimens * deficient iduronate-2-sulfatase enzyme activity as measured in plasma and leukocytes * mutation consistent with mild hunter syndrome must have either: a single base substitution of the coding sequence not previously associated with severe hunter syndrome phenotype or an exon-skipping mutation that would allow for occasional production of (minimal amounts of) normal protein --patient characteristics-- cardiovascular: no severe cardiac disease pulmonary: no severe respiratory disease other: * must have iq score of 80 or higher * effective contraception required of all fertile patients

Keywords: inborn errors of metabolism mucopolysaccharidosis mucopolysaccharidosis ii rare disease
comparison of sacral interface pressure in healthy volunteers on two dynamic pressure-prevention support surfaces

Conditions: Healthy Volunteer; Pressure Distribution

Summary: the purpose of the research study is to investigate the peak sacral interface pressures of two separate hospital bed systems in the supine and 30 degrees head-of-bed elevation position.


Eligibility criteria:
inclusion criteria: * non-disabled * can walk \& stand independently * can visit uab sim lab once for 45 to 60 minutes exclusion criteria: -skin breakdown or compromising skin conditions

Keywords: pressure injury pressure mapping
taping versus conventional physiotherapy in knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: the purpose of this study is to determine the effects of kinesio taping versus conventional physiotherapy in women with knee osteoarthritis.

* this study will be a randomized control trial. the calculated sample size for this study was 68 (34 in each group). to compensate the expected dropouts the sample size was increased by 15 %. hence the final sample size will be 80 (40 in each group). * the participants of this study will be female patients having grade.2 knee osteoarthritis aged in between 50 to 60 years having body mass index (bmi) range 25-29.9(overweight), who are being referred to dow ojha physiotherapy out patient department. the subjects will be divided into 2 equal groups through randomization technique (coin toss). * intervention group will receive regular physiotherapy exercises with kinesio tape application, whereas control group will be given the same exercises without kinesio taping. * first assessment will be done at the baseline and second(final) will be conducted at the end of 3rd week (after 9 sessions). * data will be analyzed through spss (statistical package for the social sciences) version-26. for mean comparison of dependent variables among experimental and control group repeated measure two-way analysis of covariance will be performed. p-value less than 0.05 will be considered significant.

Eligibility criteria:
inclusion criteria: * women diagnosed with knee osteoarthritis who are being referred to physiotherapy opd of dow university ojha campus. * having grade-2 osteoarthritis (mild).) * aged between 50 to 60 years. * bmi (25-29.9) -category overweight . * in case of bilateral knee pain, the most painful side will be identified for intervention to see the outcome. exclusion criteria: * total knee replacement done or any other knee surgeries. * rheumatoid arthritis. * intra articular injections received within a month. * knee oa -grade1(doubtful), grade3 (moderate)and grade 4 (severe). * altered skin sensation around the knee area. * having known sensitivity to tape materials. * underlying skin disorders. * recent knee trauma or fracture.

Keywords: knee osteoarthritis kinesio taping exercises overweight female patients degenerative disease
reducing adult inpatients anxiety with virtual reality meditation

Conditions: Anxiety; Virtual Reality

Summary: the purpose of the study is to evaluate if non-invasive, distracting devices (virtual reality) can decrease anxiety and improve affect and satisfaction in adult, hospitalized patients.


Eligibility criteria:
inclusion criteria: * between age 18-99 * hospitalized at stanford health care * english-speaking exclusion criteria: * significant cognitive impairment or inability to consent * current nausea * visual problems or currently using corrective glasses that are incompatible with the virtual reality headset * a history of severe motion sickness * a history of seizures cause by flashing light * clinically unstable or require immediate/urgent intervention
six-month performance of meniscal wall infiltration under ultrasound to treat stable degenerative meniscal injuries.

Conditions: Osteoarthritis, Knee

Summary: the main hypothesis of the study is that in situ infiltration of the meniscal lesion would provide patients with lasting and greater relief than intra-articular infiltration. a statistically significant difference would be if the lysholm score of the meniscal wall group at 3 months is 9.5 points higher than that of the intra-articular infiltration group. the aim is to evaluate the effectiveness of meniscal wall infiltration under ultrasound in the treatment of stable degenerative meniscal lesions versus intra-articular infiltration (gold standard) at 3 months by lysholm's algo-functional score.


Eligibility criteria:
inclusion criteria: * patients with a symptomatic meniscal lesion of a degenerative nature, isolated or associated with early osteoarthritis or chondropathy (ahlbach stages 1 and 2). * indication for peri-meniscal infiltration under ultrasound control of the knee for a clinically stable degenerative meniscal lesion confirmed by mri and radiography. * patient who has given free and informed consent. * patient who has signed the consent form. * patient affiliated or beneficiary of a health insurance plan. * adult patient (≥18 years of age). exclusion criteria: * no iconographic evidence of meniscal injury. * associated lesions of the central pivot of the knee. * knee pain of osteoarthritic origin strongly suggested by the clinic associated with an advanced radiological stage of osteoarthritis (ahlbach stages 3 and 4). * presence of a skin lesion at the infiltration sites. * suspected soft tissue or joint infection. * patient participating in research involving human subjects defined as category 1. * patient in an exclusion period as determined by another study. * patient under court protection, guardianship or trusteeship. * patient unable to give consent. * patient for whom it is impossible to give informed information. * pregnant, parturient or breastfeeding women.

Keywords: knee, osteoarthritis, meniscus, lysholm score, corticoids infiltration
intervention for human papillomavirus vaccine acceptance in mexican mothers

Conditions: Papillomavirus Infections; Papillomavirus Vaccines

Summary: randomized clinical trial with two groups, with a test-retest model, with single-blind approach, using a probabilistic sampling and the population was mothers of girls aged 9 to 12 years from a public elementary school in the state of puebla. the objective was to determine the effect of the intervention "vaccine for hpv prevention" aimed at the acceptance of the hpv vaccine in mothers of girls aged 9 to 12 years old in the urban area of the state of puebla.

introduction: human papillomavirus is a serious health problem worldwide, being immunization the viable prevention strategy to combat the infection, however, there is a low acceptance of the vaccine in mothers to immunize their daughters, derived from social, economic, cultural and educational aspects. objective: to determine the effect of the intervention "vaccine for hpv prevention" aimed at the acceptance of the hpv vaccine in mothers of girls aged 9 to 12 years old in the urban area of the state of puebla. methodology: randomized clinical trial with two groups, with a test-retest model, with a single-blind approach, a probabilistic sampling was used and the population was 10 mothers of girls from 9 to 12 years old from a public elementary school in the state of puebla.

Eligibility criteria:
inclusion criteria: * women from 20 to 59 years old. * mothers of girls from 9 to 11 years old. * who agree to participate in the study. * who know how to read and write. * who have an electronic device (cell phone, tablet or computer). * that they have access to social networks such as whatsapp and facebook. * that they have an internet connection. exclusion criteria: * mothers with a history of cacu and/or hpv infection in themselves or a family member. * mothers who have received information about cacu, hpv and/or the hpv vaccine at least one month prior to the educational intervention.

Keywords: papillomavirus infections human papillomavirus vaccine intervention for mothers behavioral change
incidence rate and risk factors of malnutrition in icu

Conditions: Malnutrition

Summary: to assess the incidence of malnutrition in surgical intensive care unit by nutric score. to determine the different risk factors of malnutrition

to assess the incidence of malnutrition in surgical intensive care unit by nutric score. to determine the different risk factors of malnutrition by assessment of the type of nutrition, caloric adequacy, and actual caloric intake, laboratory investigations twice weekly

Eligibility criteria:
inclusion criteria: * adult patients who will be admitted to surgical icu. * both sexes. exclusion criteria: * • referral from another hospital or other icu