Kornimate/medical-research-clean huggingface dataset:
application of vibration wave therapy to the children suffering from cerebral palsy and tongue spastic dysarthria

Conditions: Cerebral Palsy; Spastic Dysarthria

Summary: vibration therapy is the widely used in many neurological disorders for different type of problems. recently, it is being used by researchers for the betterment of motor disorders and muscle movements of the cerebral palsy patients and significant results are obtained. investigators are conducting this research to explore that whether this therapy can have some effect on the spastic tongue dysarthria of the cerebral palsy patients.

this study is going to be conducted in collaboration with shahbaz khalid ranjha , speech language pathologist, family health hospital islamabad who is the main person for the idea of the study and national university of science \& technology. this study is funded by higher education commission of pakistan. recruitment and intervention work will be carried out in family health hospital. special device is being designed for transmission of vibration waves in lab of the university. the device is capable to transmit vibration waves to the patient. urdu language phonological and articulation test(taapu) will be used for assessment as it is specially designed for urdu language population which will be the main focus. investigators have defined speech parameters for analysis which will be collected before application of intervention, after 3 months and then at the end of the study. parents assessment will be collected and noted through out the intervention.

Eligibility criteria:
inclusion criteria: * children having dysarthria due to cerebral palsy * dysarthria due to damage in motor speech area/ broca area. * children having type spastic dysarthria exclusion criteria: children diagnosed with following are excluded from our study * any speech disorders * hearing impairments * cleft palate * tongue tie.

Keywords: neurorehabilitation vibration neurotransmission cerebral palsy dysarthria
infrared thermography for the diagnosis of musculoskeletal pain

Conditions: Healthy; Pain; Temperature Change, Body

Summary: this study sought to evaluate the vasomotor response in the pain referral area of healthy individuals, performing the same procedure with and without the experience of delayed onset muscle soreness.

validity of infrared thermography for properly diagnosing musculoskeletal pain and their clinical applicability is lacking. this study investigates temperature changes on the upper extremity before and after a suprathreshold stimulation (painful stimulus) with a digital algometer over the infraspinatus muscle. the same procedure is performed in two consecutive days, 24 hours apart (day-1 and day-2). at the end of day-1, an eccentric exercise is performed in order to to induce delayed onset muscle soreness on the external rotators of the shoulder.

Eligibility criteria:
inclusion criteria: * being healthy and free from any pain specific to the upper limbs and/or in general. exclusion criteria: * previous history of chronic pain. * any systemic diseases or regional pathology which can interfere with the outcome measures.

Keywords: musculoskeletal pain delayed onset muscle soreness pain sensitivity infrared thermography referred pain
assessment of the bioavailability of iron in iron fortified bouillon cubes in healthy nigerian women

Conditions: Iron Deficiency Anemia

Summary: the prevalence of iron deficiency anemia is a wide spread problem in africa and iron fortification can be an effective strategy to decrease this. in the current study adding different levels of a stabilizer to iron fortified cubes and it's effect on iron bioavailability from these cubes will be studied in the context of a nigerian meal in women. 24 female subjects with low serum ferritin levels will be included in the study. the study will last 64 days and subjects will be asked to consume a breakfast and lunch prepared with a bouillon cube with isotope labeled iron during 3 periods of 5 consecutive days. the absorption of iron will be evaluated after every period and compared between the cubes.


Eligibility criteria:
inclusion criteria: * healthy female nigerian subjects; * age \> 18 and \<40 years at screening; * body weight \<65 kg; * apparently healthy: no medical conditions which might affect study measurements (judged by study physician); * with iron deficiency judged by a serum ferritin concentration of \<15µg/l; * reported intense sporting activities ≤ 10h/w; * reported alcohol consumption ≤ 14 units/w; * willing and able to participate in the study; * having given a written informed consent. exclusion criteria: * being an employee of unilever or the department of family, nutrition and consumer science of the obafemi alowolo university; * blood donation or significant blood loss over the past 6 months; * being severely anemic (hemoglobin \< 8.0 g/dl) * reported use of any medically- or self-prescribed diet; * use of vitamin or mineral supplements and unwillingness to discontinue their use one week prior the study and during the study; * smoking or consuming tobacco in any form, and/or was smoking or consuming tobacco in any form for 6 months preceding the study and/or will be smoking or consuming tobacco in any form, during the study; * is pregnant or will be planning pregnancy during the study period; * is lactating or has been lactating in the 6 weeks before pre-study investigation and/or during the study period; * known gastrointestinal (including helminth infection) or metabolic disorders; * participation in another clinical trial during the last 30 days prior to the beginning of the study; * symptomatic malaria (no blood smear analyses on malaria required)

Keywords: iron fortification bioavailability nigeria women bouillon cubes
treatment of humeral fractures with long philos plates using a modified technique and approach avoids radial nerve palsy

Conditions: Humeral Fracture

Summary: radial paralysis is a well-known complication of plate osteosynthesis on the humeral shaft. at the university hospital basel, these fractures have been treated in an adapted procedure with long philos plates using a modified technique and approach. this study is to retrospectively analyze the effectiveness of the surgical technique in relation to iatrogenic radial paralysis.

radial paralysis is a well-known complication of plate osteosynthesis on the humeral shaft. with regard to surgical treatment, there are major differences in terms of surgical access and implant selection. at the university hospital basel, these fractures have been treated in an adapted procedure for about 10 years. a long philosplatte (synthes company) is inserted from the proximal end via a deltoido-pectoral approach. this is a minimally invasive procedure (mipo = minimally invasive plate osteosynthesis). the standard implant is first twisted distally by approx. 45°-90° and then lies anterior to the humerus. the distal screws can then be filled via anterior stab incisions. this adapted surgical technique is adapted to the anatomical course of the radial nerve. this ensures a safe distance from the plate/access to the nerve. the nerve does not have to be explored openly and the distal row of screws can be used minimally invasively via stab incisions. this study is to retrospectively analyze the effectiveness of the surgical technique in relation to iatrogenic radial paralysis.

Eligibility criteria:
inclusion criteria: * surgery at the university hospital basel between 06/2010 and 12/2020 for a proximal humeral shaft fracture exclusion criteria: * patients with a documented rejection

Keywords: philos plate minimal invasive plate osteosynthesis (mipo) radial paralysis
efficacy and optimal dose selection of intranasal dexmedetomidine during breast lumpectomy under local anaesthesia

Conditions: Intranasal Dexmedetomidine Breast Cancer Local Anaesthesia

Summary: this trial is going to evaluate the safety and effectiveness of intranasal dex(dexmedetomidine) in breast lumpectomy under local anaesthesia,and to investigate the optimal dose of intranasal dex in breast lumpectomy.

breast lumpectomy associated with a high level of anxiety, fear and pain requires fast and effective anaesthesia techniques. presently, this procedure is usually performed under general or local anaesthesia. general anaesthesia provides an effective sedation; however, for minor procedures, general anaesthesia is resource-intensive and postoperative complications, such as nausea, vomiting or extended time to ambulation, are more likely. local anaesthesia alone may be uncomfortable or uncooperative for patients. therefore, an efficient drug regimen is required that reduces analgesic consumption, minimises opioid-related side effects and shortens post-anaesthesia care unit (pacu) stay following surgery. dexmedetomidine (dex) is a highly selective α2 adrenoreceptor agonist that provides sedation without respiratory depression. its sedative, anxiolytic, analgesic and haemodynamic effects have made it a useful adjunct to anaesthesia and sedation. dex may provide a conscious sedation under monitored anaesthesia care (mac) that is a logical middle ground between general anaesthesia and local anaesthesia. intranasal dex was recently shown to provide satisfactory anaesthesia and premedication sedation in healthy volunteers and paediatric patients. the intranasal route is not only effective, but also well-tolerated and convenient this trial is going to evaluate the safety and effectiveness of intranasal dex(dexmedetomidine) in breast lumpectomy under local anaesthesia, and to investigate the optimal dose of intranasal dex in breast lumpectomy.

Eligibility criteria:
inclusion criteria: * with asa(american society of anesthesiologists) physical status i and ii * scheduled for breast lumpectomy exclusion criteria: * a history of heart block * upper respiratory tract infection * asthma * allergy to dex or local anaesthetics * memory or cognitive dysfunction * pregnancy * lack of understanding the consent process * impaired liver or renal function * a history of drug or alcohol abuse

Keywords: intranasal dexmedetomidine anaesthesia breast lumpectomy
analysis of changes in adipose tissue of patients with lipoatrophy hiv infection treated with nucleoside thymidine, after switching to monotherapy with lopinavir / ritonavir

Conditions: HIV Infections

Summary: the objective is to analyse the changes in the adipose tissue hystological features and the adipogenesis gene expression and related to inflammation after 48 and 96 weeks after the change from azt+3tc+abc (trizivir®) to a monotherapy treatment with lpv/r (kaletra®)


Eligibility criteria:
inclusion criteria: * patients infected with vih-1, documented with a positive hiv-1 antibody test and/or positive pcr, confirmed for hiv-1 rna. * patients treated with a haart that should contain azt+3tc+abc (trizivir®) * patients with an indetectable viral load, which will be defined \<40 copies/ml within the last six months. * patients with a lipoatrophy clinical evidence (which will be defined as moderate or severe, according to the lipodystrophy severity grading scale). * men or women aged ≥ 18. * for women of childbearing potential, negative urine pregnancy test during the screening visit. * patients that have signed and dated the informed consent form prior to any study-specific procedure. exclusion criteria: * patients with evidence of protease inhibitors failure, and/or documented evidence of protease gene resistance mutation. this evidence could be prior or during the inclusion period in the study. * patients who, for any reason could not be treated with lpv/r. * cachexia, defined as an body mass index \<17 kg/m2. * pregnant or breastfeeding women, or women of childbearing potential who do not use the appropriate contraceptive method, according to the investigator judgment. * clinically relevant disease or condition, according to the investigator judgment, three months prior to the patient inclusion in the study. * patients taking the following concomitant medication that could affect the adipocyte function or morphology, such as: insulin, steroids, anabolic steroid, anti-inflammatory medication for more than three months.

Keywords: hiv 1 patients
monitoring patients with uncontrolled epilepsy

Conditions: Epilepsy; Seizures

Summary: this study is designed to evaluate patients with uncontrolled seizures. seizures can be associated with and monitored by abnormal electrical activity in the brain. in this study researchers will use video-electroencephalography (eeg) to monitor patients with uncontrolled or suspected seizures. eeg works by measuring electrical activity in different areas of the brain. the video-eeg allows researchers to examine changes in the eeg along with the clinical features of seizures as they occur. in addition to monitoring electrical activity of the brain, researchers will take frequent antiepileptic drug blood levels. these measures will allow researchers to learn more about how each drug is absorbed and metabolized in the body. the information collected in the study will be used to place patients into other scientific studies testing new therapies for epilepsy.

in this study we will use standard clinical studies, including simultaneous video-eeg monitoring, to evaluate patients referred for uncontrolled or suspected seizures. the protocol will be used to screen patients for inclusion in other protocols, follow the natural history of seizure disorders, and train fellows in the evaluation and treatment of epilepsy. both inpatients and outpatients will be studied.

Eligibility criteria:
history of uncontrolled seizures, at the present time, at least during 6 months of the past 3 years, and preferably a continuous pattern of seizures during the few months prior to admission. seizure frequency, by history, must be sufficient to make video monitoring effective. priority will be given to patients whose seizures occur once or more per day. patients of any age may be accepted. patients (and parents or guardians, if applicable) must express willingness to cooperate with the entire protocol, to be willing to undergo further diagnostic tests if needed, and to return for follow up evaluation at intervals as needed.

Keywords: anticonvulsants intensive monitoring epilepsy
evaluation of updated procedure for management of refractory out-of-hospital cardiac arrests

Conditions: Cardiac Arrest, Out-Of-Hospital

Summary: ecpr is a technique that has been rapidly developed in many cardiac arrest specialized centers in 2013, a specific management protocol was developed for patients in refractory out-of-hospital cardiac arrest around nancy, france. to select patients with the best prognosis, the inclusion criteria defined were strict. this led to an over-selection of patients and a significant reduction in the number of eligible patients. a balance needed to be struck between over-selecting patients and maintaining the expertise of medical and paramedical teams in the field. in addition, it has also been shown that ecpr also increases the number of organs and transplants. in february 2024, the criteria for inclusion in the protocol were redefined to include any witnessed non-traumatic cardiac arrest, whatever the initial rhythm. this simplification should enable more patients to be included in the procedure. the aim of the study is to assess the patient's outcome


Eligibility criteria:
inclusion criteria: * out-of-hospital cardiac arrest * enrolled in the ecpr program * 18 years old or more * low-flow estimated \<60minutes exclusion criteria: * traumatic cardiac arrest * major comorbidities
transdermal nicotine in female patients at high risk for post operative nausea and/or vomiting (ponv)

Conditions: Postoperative Nausea and Vomiting

Summary: the purpose of this study is to see if the nicotine patch reduces post operative nausea and/or vomiting (ponv) among non-smoking patients who are at high risk of ponv.

there are certain known risk factors for post-operative nausea and/or vomiting: the use of opioids during surgery, female gender, laparoscopic surgery, gynecologic surgery, strabismus repair, the use of a general anesthetic, obesity, and non-smoker. patients with four or more of these risk factors have an 80% occurrence rate of post-operative nausea and/or vomiting and are classified as "high risk". it has been shown that those who use tobacco have about a 50% reduction in post-operative nausea and/or vomiting.

Eligibility criteria:
inclusion criteria: * age 18-65 * female * health patient or acute illness * undergoing outpatient-type general surgery, especially those associated with increased incidence of post-operative nausea and/or vomiting such as gynecological procedures * undergoing general anesthesia for the surgery * receiving opioids during surgery * non-smokers exclusion criteria: * history of any heart condition * history of uncontrolled hypertension, or presence of any condition that could be made drastically worse by an increase in blood pressure * history of an aneurysm * active tobacco use within the past five years * works or lives in the presence of cigarette smoke * pregnant * mentally ill * prisoners * history of allergic reaction to nicotine or to adhesive patches * history of allergic reaction to propofol, versed, fentanyl, zofran, decadron, and reglan

Keywords: post operative nausea and vomiting gynecological surgery outpatient surgery nicotine patch laparoscopic surgery
beliefs about mental health treatment - gambling addiction study in colorado

Conditions: Gambling Disorder; Gambling Problem; Mental Health Issue

Summary: many people with mental health conditions do not seek treatment, and it is unclear what exactly prevents people from taking up treatment. the goal of this interventional study is to learn about how people think about cognitive behavioral therapy (cbt) for gambling disorders. the main questions it aims to answer are: * do people have incorrect beliefs about the net benefits of cbt? if yes, which beliefs are those, and how much do people underestimate or overestimate the benefits? * is a small monetary incentive (that participants receive conditional on trying out cbt) helpful in increasing take-up of cbt? apart from these questions, the researchers will also study how well cbt works to treat gambling disorders. participants will be asked to complete two surveys over four months and might be offered a modest monetary incentive for doing (free) cbt if they are in the treatment group. researchers will compare that treatment group to a control group. participants in the control group will have access to free cbt and do the same two surveys as those in the treatment group, but will not receive the monetary incentive.


Eligibility criteria:
inclusion criteria: * must reside in colorado * must be english-speaking exclusion criteria: * does not reside in colorado * is not english-speaking

Keywords: beliefs bias incentive
multi-center evaluation of feasibility of spect measurement of myocardial blood flow and reserve

Conditions: Coronary Artery Disease

Summary: patients will be recruited from those referred to the local site's diagnostic imaging department for spect myocardial perfusion imaging (mpi) ,who have an intermediate to high pre-test likelihood of disease (diamond-forrester criteria ≥ 30%) and are clinically indicated to have an mbf study.

patients will be recruited from those referred to the local site's diagnostic imaging department for spect myocardial perfusion imaging (mpi), who have an intermediate to high pre-test likelihood of disease (diamond-forrester criteria ≥ 30%) and are clinically indicated to have an mbf study. research imaging will consist of a spect acquisition at the time of rest and stress radiotracer injection in addition to the standard (delayed) clinical stress/rest spect scan with 99mtc-tetrofosmin. this is an observational study; patients will be managed according to the standard clinical care of the local site. where available, a ct scan will also be acquired for attenuation and/or scatter correction. studies may be one day (rest/stress or stress/rest) or two day (rest and stress on separate days) all studies will be analyzed locally but the raw data will also be anonymized and forwarded to the core facility for reprocessing. central processing will allow comparison between sites and the repeat processing will provide an estimate of inter-operator variability in the measurements. the core lab will also compare the relative perfusion from immediate and delayed imaging for image quality and diagnostic accuracy (visual and quantitative).

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * bmi ≤ 40 kg/m2 * able and willing to comply with the study procedures * written informed consent * intermediate to high probability of cad * suspected or known cad on a stable medication regime exclusion criteria: * history or risk of severe bradycardia (heart rate \< 50 beats per minute) not related to chronotropic drugs * known second- or third-degree av block without pacemaker * dyspnea (nyha iii/iv), wheezing asthma or copd * coronary artery bypass graft (cabg) surgery within 60 days prior to screening or within 45 days after consent (early revascularization) * percutaneous coronary intervention (pci) within 30 days prior to screening or within 45 days following consent (early revascularization) * recent use of dipyridamole, dipyridamole-containing medications (e.g. aggrenox) * known hypersensitivity to dipyridamole or adenosine * breastfeeding or pregnancy * claustrophobia or inability to lie still in a supine position * unwillingness or inability to provide informed consent

Keywords: myocardial blood flow spect
effects of gastric bypass surgery on bile acid homeostasis

Conditions: Obesity

Summary: the purpose of this study is to determine whether the bile acid circulation is changed after gastric bypass surgery. further, to account for how the changed anatomy of the gut influences how the bile acid and food is mixed in the gut and how this is associated with the changes in gut hormone release after the surgery. our hypothesis is that bile acid reabsorption from the gut is increased as animal models suggest so and bile acid blood concentration increases after surgery.


Eligibility criteria:
inclusion criteria: * age between 25 and 65 years * for patients: uncomplicated roux-en-y gastric bypass surgery more than 12 months before study initiation * for controls: age, bmi and gender matched with patient group exclusion criteria: * previous removal of gall bladder or other abdominal surgeries except appendectomy (and gastric bypass surgery for patient group) * known liver disease or thyroid disease requiring antithyroid medication * chronic gastrointestinal symptoms * any chronic disease interfering with, or susceptive of interfering with appetite or gastrointestinal function * any medication interfering with, or susceptive of interfering with appetite or gastrointestinal function * smoking within the last month * alcohol consumption above 168 grams per week * currently pregnant or breast-feeding * anaemia with haemoglobin \<6,5 mmol/l (\<117 mg/dl) * loss or gain of more than 3 kg within the last 3 months

Keywords: roux-en-y gastric bypass surgery bile acid circulation obesity bariatric surgery