Kornimate/medical-research-clean huggingface dataset:
the effects of smoking on mortality in patients with acute respiratory syndrome coronavirus 2 infection

Conditions: Covid19; Smoking

Summary: this is a retrospective single centered study that was done in the icu on patients with covid-19 between 16th of march -16th of may in 2020 retrospective records will be examined by examining the electronic data files of the patients. there were two groups as smoker and non-smoker.

the aims of the present study is to see the effects of smoking prevalence, the length of stay regarding the usage of cigarettes, and the effects on the mortality of covid-19 in our intensive care unit(icu). this is a retrospective single centered study that was done in the icu on patients with covid-19 between 16th of march -16th of may in 2020. the demographic data, comorbidity status, the units they were accepted from, clinical symptoms , respiratory support, prevalence of smoking, length of stay in the icu and mortalities of the patients weill be recorded. there are two groups as smoker and non-smoker.

Eligibility criteria:
inclusion criteria: * all the patient's data are diagnosed with acute respiratory syndrome covid-19 over 18 years old exclusion criteria: * patients under 18 years of age
effects of open thoracic paravertebral block on postoperative analgesia

Conditions: Lung Cancer

Summary: the study was aimed to assess the effects of open thoracic paravertebral block on postoperative analgesia in patients undergoing open pulmonary lobectomy under general anesthesia. then, a total of 90 patients with american society of anesthesiologists (asa) scores of ⅰ or ⅱ, scheduled for open pulmonary lobectomy under propofol - remifentanil total intravenous anaesthesia, were randomly divided into pcia group (group g), ultrasound-guided tpvb combined with pcia group (group u), and open tpvb combined with pcia group (group e).finally, the study find that open tpvb can provided satisfactory analgesia for patients undergoing open pulmonary lobectomy under general anesthesia, and the analgesia efficacy was equivalent to the tpvb under ultrasound guidance,which should be popularized.

purpose: the study was aimed to assess the effects of open thoracic paravertebral block on postoperative analgesia in patients undergoing open pulmonary lobectomy under general anesthesia. methods: a total of 90 patients with american society of anesthesiologists (asa) scores of ⅰ or ⅱ, scheduled for open pulmonary lobectomy under propofol - remifentanil total intravenous anaesthesia, were randomly divided into 3 groups (n = 30 each) by using a random number table: pcia group (group g), ultrasound-guided tpvb combined with pcia group (group u), and open tpvb combined with pcia group (group e). in group g, patients were received pcia after the surgery. in group u, tpvb was performed on the operated side under ultrasound guidance with 0.25% ropivacaine 30 ml combined with the pcia after the surgery. in group e, the tpvb was performed under the direct vision with 0.25% ropivacaine 30 ml combined with the pcia. the visual analogue score (vas) at rest and during coughing, the sensory nerve block segment, as well as the respiratory rate were measured and recorded at different time-points. furthermore, the hemodynamic vital signs at different time - points, the number of successfully delivered doses 48 h after the surgery, as well as the incidence of postoperative complications were also recorded and analyzed.

Eligibility criteria:
inclusion criteria: * with american society of anesthesiologists physical status ⅰor ⅱ * aged 35 - 75 years old * with body mass index of 20 - 25 kg／m2, * scheduled for open pulmonary lobectomy under general anaesthesia at the first affiliated hospital of kunming medical university exclusion criteria: * cardiovascular and/or cerebrovascular disease; * diabetes; pre-existing liver, lung or kidney dysfunction; * bilateral surgery; take operations again within 48 h after the surgery; * with serious pulmonary infection and coagulation dysfunction

Keywords: thoracic paravertebral block postoperative analgesia pulmonary lobectomy
effect of obstructive sleep apnea on glucose control and cognitive function

Conditions: Cognitive Change

Summary: obstructive sleep apnea (osa) may contribute to altered cognitive function in patients suffering from severe osa. and lifestyle modification program may improve the cognitive function after 6 months of therapy.


Eligibility criteria:
inclusion criteria: * bmi ≥ 25kg/m2 * impaired glucose tolerance which defined as plasma glucose at the range of 7.8 and 11 mmol/l 2 hours after 75g oral glucose solution intake, * willing to participate in lifestyle modification program * and capable of using continuous glucose monitoring (cgm) as judged by investigator exclusion criteria: 1. lactating or pregnant, 2. known diabetes, current or previous use of glucose lowering drug 3. current participation in other weight loss or lifestyle interventions, or use of weight loss drugs, 4. current use of steroids 5. uncontrolled thyrotoxicosis 6. allergy to medical grade adhesives 7. known obstructive sleep apnea on continuous positive airway pressure therapy 8. symptoms of cognitive deterioration (according to the hong kong montreal cognitive assessment (hk-moca) at the score of \<21) 9. predominant central sleep apnea 10. uncontrolled hypertension (blood pressure \>140/90mmhg) or requiring more than two anti-hypertensive medication 11. history of stroke or brain injury, 12. unstable cardiovascular disease (e.g. recent unstable angina or myocardial infarction within the previous 6 months or severe left ventricular failure; neuromuscular disease affecting or potentially affecting respiratory muscles; moderate to severe respiratory disease (i.e. breathlessness affecting activities of daily living) or documented hypoxemia or awake sao2 \<92%) 13. psychiatric disease that limits the ability to give informed consent or complete the study 14. use of psychoactive medication.
effect of class iv laser therapy and pilates exercises on bone density and pain in primary osteoporosis: a randomized controlled trial

Conditions: Osteoporosis

Summary: the current study was to investigate the effect of class iv laser therapy and pilates exercises on bone density in osteoporosis.sixty patients with osteoporosis (t-score values below -2.5) in lumbar spine with no evidence of vertebral compression fractures were recruited from october 6 university hospital and kaser el-aini hospital, cairo - egypt from february 2019 to november 2019. their age ranged from 40 to 60 years old. patients with a history of tumors, ovariectomy, heart disease, renal failure, disc prolapse, or any trauma to the back area were excluded from the study

they were allocated randomly into three groups: group a consists of 20 patients received a multiwave locked system laser, group b consists of 20 patients received pilates exercises and group c consists of 20 patients received a multiwave locked system laser and pilates exercises. patients with a history of tumors, ovariectomy, heart disease, renal failure, disc prolapse, or any trauma to the back area were excluded from the study. all patients who participated in the current study did not intake any medications to accelerate bone density like vitamin d or calcium. the randomization method was applied by asking each patient to choose a piece of paper that the (a), (b), or (c) letter was written. (a) considered the lllt group, (b) considered the pilates exercise group, while (c) considered the lllt and pilates exercises group. both patients, the examiner, and therapist were blinded from the selection process.

Eligibility criteria:
inclusion criteria: * patients with osteoporosis (t-score values below -2.5) exclusion criteria: * patients with a history of tumors, ovariectomy, heart disease, renal failure, disc prolapse, or any trauma to the back area

Keywords: osteoporosis, lllt, multiwave locked system laser, physical therapy modalities, dexa, pilates exercises
alberta cancer exercise hybrid effectiveness-implementation study

Conditions: Neoplasms

Summary: the primary purpose of this proposed 5-year hybrid effectiveness and implementation study is to evaluate the relative benefit from, and implementation of an alberta wide clinic-to-community-based cancer and exercise model of care - the alberta cancer exercise (ace) program. the investigators hypothesize that the strategy will improve the physical well-being and qol of survivors (on and off cancer treatment) while preventing the development of secondary cancers.

a total of 2500 adult cancer survivors will be enrolled in the 5-year study. the investigators will build capacity by expanding ace training and programming to sites beyond the large urban centers. the investigators plan for implementation in 7 alberta ymcas and/or city recreation facilities within 3 years, as well as to formally establish partnerships within ahs to build further capacity across the province within existing ahs programming (e.g., cancercontrol rehab services, alberta healthy living program and primary care network). virtual and supported home-based options will be available as an alternative. eligible and consenting participants will be screened for exercise safety, and following fitness testing will be triaged to appropriate exercise programming in their home or community. the exercise intervention will take place at the survivor's home, ymcas and municipal fitness centres across the province. the supported home-based and community-based exercise program will be administered by exercise specialists who have undergone the ace cancer and exercise: training for fitness professionals course. survivors will take part in a combination of aerobic, resistance, balance, and flexibility exercises delivered in a circuit-type class setting or group personal training format, twice weekly for an 8-to-12-week period. effectiveness outcomes include physical fitness, physical activity, quality of life, and healthcare utilization. these outcomes are known factors associated with the secondary prevention of cancer. the re-aim framework will be used to evaluate program reach, effectiveness, adoption, implementation and maintenance. the alberta quality matrix for health will serve as a framework to inform program sustainability beyond the funding period. through this research, the investigators will better understand the effectiveness of the ace program, and evaluate processes to support future implementation and sustainability.

Eligibility criteria:
inclusion criteria: 1. have a diagnosis of cancer; 2. be over the age of 18 years; 3. be able to participate in low-intensity levels of activity at minimum; 4. be pretreatment, or receiving active cancer treatment (i.e., surgery, systemic therapy and radiation therapy), or have received cancer treatment within the past 3 years; or have ongoing significant cancer or treatment-related impairments (requiring supportive exercise intervention); 5. be able to provide informed written consent in english. exclusion criteria: 1) inability or deemed unsafe to participate in physical activity program -

Keywords: cancer exercise
the effect of breathing exercise applied with incentive spirometer

Conditions: Breathing Exercises; Cardiac Surgery; Incentive Spirometry

Summary: it was conducted as a single-center, prospective, randomized controlled experimental study. data were collected with the introductory information form, numerical rating scale, physiological parameters follow-up form and general comfort scale.

it was conducted as a single-center, prospective, randomized controlled experimental study. data were collected with the introductory information form, numerical rating scale, physiological parameters follow-up form and general comfort scale.the study was conducted in three groups. individuals in the intervention-1 group were asked to perform breathing exercises with is in addition to the routine practices of the clinic for 5 days in the postoperative period. individuals in the intervention-1 group were asked to perform breathing exercises with is in addition to the routine practices of the clinic for a total of 10 days, 5 days in the preoperative period and 5 days in the postoperative period. individuals in the control group were given only the routine practice of the clinic.

Eligibility criteria:
inclusion criteria: * able to communicate in turkish, * undergoing cardiac surgery, * no pain in the preoperative period (0 pain according to va), * have no problems with vision, hearing or speech, * individuals who agreed to participate in the study were included. exclusion criteria: * using psychiatric medication, * using immunosuppressive medication until 30 days before surgery, * with neuromuscular disorders, * having rheumatic disease, * have had pulmonary surgery before, * with cerebrovascular injury, * diagnosed with cardiovascular instability or aneurysm, * diagnosed with copd, * individuals who do not volunteer to participate in the study
assessment of adherence and efficiency of a home-based training program on muscular strength, endurance and qol for colon cancer patients

Conditions: Colon Cancer

Summary: the purpose is to assess the adherence and the efficiency of a home-based training program on muscular strength, endurance and the quality of life, fatigue, physical activity, anxiety and depression for colon cancer patient treated by chemotherapy.

it's a 9-weeks experimentation with 4 moments (every 3 weeks) to do the tests.

Eligibility criteria:
inclusion criteria: * colon cancer patients treated by chemotherapy adjuvant exclusion criteria: * patients who have metastasis * patients hospitalized during the experimentation * patients who have major orthopedic or neurologic problems
urdu translation of duke activity status

Conditions: Heart Diseases

Summary: to translate, culturally adapt, and validate the duke activity status index (dasi) to the pakistani urdu language. the study will measure the reliability \& validity of dasi in the urdu version.no study has been conducted in the pakistan region to translate dasi which follows the proper cross-culture adaptation.

literature suggested that duke activity index (dasi) is a questionnaire originally developed in english to evaluate the functionality. dasi was used primarily to assess patients with cardiovascular diseases such as coronary artery disease, heart failure, myocardial ischemia, and infarction. in clinical practice, dasi can be used to know the effects of medical treatments and cardiac rehabilitation and to assist clinical decisions in controlled clinical trials, dasi can also be used to assess interventions and as a component for assessing the costs/benefits of treatment. studies demonstrated that dasi is characterized as a questionnaire with good functional ability, evidence of validity, usefulness, and great clinical and scientific applicability, it seems to be a useful tool for evaluating cardiac patients. so, to be used with brazilian cvd patients it is necessary to validate dasi and verify its psychometric properties in this population.

Eligibility criteria:
inclusion criteria: * individuals have enough education level to understand urdu and english as well with a body mass index between 18.6 and 39.9 kg/m with the diagnosis of cardiovascular diseases such as coronary artery disease, valvular heart disease, arrhythmia with at least one symptom11 such as chest pain, palpitations, fatigue, or dyspnea, and physician referral to exercise testing. exclusion criteria: * individual is unable to read the questionnaire, who have cognitive deficits screened by mini-mental state examination according to the cut-off points and hospitalization two months before as well as acute illness, fever, or severe physical limitation that would prevent from doing the exercise test.

Keywords: duke activity status index heart diseases tool translation
acute hemostasis following the use of the aquabeam® system for the treatment of benign prostatic hyperplasia

Conditions: Benign Prostatic Hyperplasia

Summary: a single-arm prospective, interventional clinical trial to evaluate the safety and performance of obtaining hemostasis with commercially approved catheters following prostate resection using the aquabeam for treatment of luts resulting from bph.

procept biorobotics has developed the aquabeam, a personalized image-guided waterjet resection system that utilizes a high-velocity saline stream to resect and remove prostate tissue in males suffering from lower urinary tract symptoms (luts) due to bph. the aquabeam system is intended for the resection and removal of prostate tissue in patients experiencing luts. the primary objective of the study is to evaluate the safety and performance of obtaining hemostasis with commercially approved catheters following prostate resection using the aquabeam. the time frame of the study is 7 days. up to 30 participants will be included in this single-site clinical trial. the trial is a single-arm prospective, interventional clinical study. results will be analyzed to determine the safety and efficacy of commercially approved catheters for the achievement of acute hemostasis without the need for cauterization.

Eligibility criteria:
inclusion criteria: * male age from 40 through 85 years with luts due to bph exclusion criteria: * any severe illness that would prevent complete study participation or confound study results

Keywords: image-guided bph aquablation aquabeam luts tissue resection robotics
effects of trigger point dry needling in individuals with patello femoral pain syndrome : a randomized controlled trial

Conditions: Patellofemoral Pain Syndrome

Summary: a double blinded clinical controlled trial will be performed on individuals with patello femoral pain syndrome in which trigger point dry needling will be given to experimental group while sham needling will be given to the control group, targeting the trigger points present in the quadriceps of affected individuals assessing the pain,functional disability and range of motion of the affected individuals.

a double blinded randomized controlled trial of 6 months study after the approval of synopsis, will be conducted. convenience sampling technique will be used to enroll the patients. patients will be selected according to predefined inclusion and exclusion criteria. all patients who fulfill inclusion criteria will be allocated in two group through randomization by lottery method. group a will receive trp-dn and group b will receive sham needling. both groups will be asked to perform stretching exercise of quadriceps daily after needling. the patients' outcomes will be measured by vas for pain intensity and kujala questionnaire for functional status. the comparison between pre-treatment and post-treatment data will be done after 3 months. informed consents will be taken from each patient. data entry and analysis will be done with spss 23.

Eligibility criteria:
inclusion criteria: - 1. both genders 2. ages range from 18-40 years 3. they have clinical diagnosis of pfps (the diagnosis was confirmed by a positive patellar grind test and tenderness of medial and lateral patellar facets) 4. participants are also required to have a minimum pain score of 3 on numeric pain scale 5. kujala patellofemoral questionnaire score of 50 to 80 before the intervention. 6. patients willing to participate exclusion criteria: * history of any following conditions 1. participants who have received any treatment for pfps within the 3 months 2. a history of lower extremities fracture or surgery 3. presence of msk diseases such as acute herniated disc or spondylolisthesis 4. history of any chronic disease e.g. diabetes mellitus

Keywords: patellofemoral pain syndrome dry needling trigger points
a prospective randomised controlled trial of management of recurrent nosebleeds in children

Conditions: Epistaxis

Summary: to determine whether the selective application of a combined treatment regimen of silver nitrate cautery and 4 weeks of naseptin cream is superior to naseptin treatment alone in the management of recurrent paediatric epistaxis.


Eligibility criteria:
inclusion criteria: * children aged 1 - 14 * history of repeated epistaxis with at least 1 episode in the previous 4 weeks prior to attending the ent clinic. * presence of prominent vessels on the anterior nasal septum on the side that reportedly bleeds (or on at least one side if bleeding is reported to be bilateral) exclusion criteria: * no prominent vessels on examination (these children will be randomised but will be prescribed naseptin alone and followed up in the same way as the children in the trial, for completeness of data) * known bleeding disorders. * allergy to peanuts, neomycin or chlorhexidine * other causes of nose bleeding eg tumour.

Keywords: paediatric epistaxis nose bleed naseptin
postoperative concurrent chemoradiotherapy in treating patients with high-risk salivary gland carcinomas

Conditions: Salivary Gland Tumors; Head and Neck Cancer

Summary: this is a non-randomized, phase ii, open label study of postoperative current chemoradiotherapy for high-risk malignant salivary gland tumors of head and neck.the primary purpose of this study is to evaluate the efficacy and safety of concurrent chemoradiotherapy in these patients.


Eligibility criteria:
inclusion criteria: 1. pathologically proven diagnosis of a malignant salivary gland tumor of intermediate or high-grade 2. pathologic stage t3-4 or n1-3 or t1-2, n0 with a close (≤ 5mm) or microscopically positive surgical margin 3. surgical resection with curative intent within 8 weeks prior to registration, with no evidence of gross tumor residual 4. no evidence of distant metastases 5. no synchronous or concurrent head and neck primary tumors 6. karnofsky score over 60 7. adequate organ function including the following: 1. absolute neutrophil count (anc) \>= 1.5 \* 10\^9/l 2. platelets count \>= 100 \* 10\^9/l 3. hemoglobin \>= 10 g/dl 4. ast and alt \<= 2.5 times institutional upper limit of normal (uln) 5. total bilirubin \<= 1.5 times institutional uln 6. creatinine clearance \>= 50 ml/min 7. serum creatine \<= 1 times uln 8. signed written informed consent exclusion criteria: 1. evidence of distant metastasis 2. prior chemotherapy or anti-cancer biologic therapy for any type of cancer, or prior radiotherapy to the head and neck region 3. other previous cancer, except for in situ cervical cancer and cutaneous basal cell carcinoma 4. pregnant or breast-feeding females, or females and males of childbearing potential not taking adequate contraceptive measures 5. presence of an uncontrolled concomitant illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, or cardiac arrhythmia

Keywords: salivary gland tumors head-an-neck cancer concurrent chemoradiotherapy high-risk cisplatin docetaxel