Kornimate/medical-research-clean huggingface dataset:
comparative effects of clamshell technique with ems vs ctin iliotibial band tightness for pain and function

Conditions: Tibial Muscular Dystrophy

Summary: iliotibial band syndrome (itbs) is a common knee injury that usually presents with pain and/or tenderness on palpation of the lateral aspect of the knee, superior to the joint line and inferior to the lateral femoral epicondyle. the current theory is that this condition is likely to be caused by compression of the innervated tissues beneath the iliotibial band (itb), leading to inflammation.

there were effects of clamshell exercises on gluteus medius, quadratus lumborum and anterior hip flexor. however their effect was limited on iliotibial band tightness. hip/knee coordination and running style have also been identified as key factors in the treatment of itbs, highlighting the complexity of the condition. the present study will focus on effect of clamshell techniques with electrical muscle stimulation versus conservative treatment in iliotibial band tightness for pain and function.the goal is to determine which technique is more effecient in improving function and reducing pain and soreness of iliotibial band.

Eligibility criteria:
inclusion criteria: * adults aged 45-65 years old (jeong et al., 2019) * both genders will be included (jeong et al., 2019) * diagnosed with iliotibial band tightness (itbt) based on clinical examination and positive noble compression test (hutchinson et al., 2022) * reporting lateral knee pain aggravated by activity (hutchinson et al., 2022) exclusion criteria: * recent history of knee surgery or other knee injuries (peterson et al., 2022) * presence of other musculoskeletal conditions affecting the knee (peterson et al., 2022) * inflammatory conditions such as rheumatoid arthritis or gout (peterson et al., 2022) * neurological conditions affecting leg function (peterson et al., 2022) * pregnancy (jeong et al., 2019)
a post-market, observational registry with the easyendotm universal linear cutting stapler in laparoscopic bariatric surgery

Conditions: Obesity; Roux-en-Y Gastric Bypass; Gastrectomy; Mini Gastric Bypass

Summary: the purpose of this observational registry is to evaluate the safety and performance of the easyendotm universal linear cutting stapler and reloads from ezisurg medical when used to create anastomoses during laparoscopic bariatric surgery. the goal of the study will be achieved by assessing the device performance and by reporting of peri- and postoperative complications in a prospectively maintained database.


Eligibility criteria:
inclusion criteria: * patient ≥ 18 years of age at registry entry. * patient and investigator signed and dated the informed consent form prior to the index-procedure. * patient has a bmi ≥ 35 kg/m2, with one or more related co-morbidities. * patient has a bmi ≥ 40 kg/m2. * patient is eligible for laparoscopic bariatric surgery. exclusion criteria: * patient is unable / unwilling to provide informed consent. * patient has a history of bariatric surgery. * patient is unable to comply with the registry protocol or proposed follow-up visits. * patient has a contra-indication for laparoscopic bariatric surgery.
diabetes prevention program in youth

Conditions: Pre Diabetes

Summary: the purpose of this study is to test the effectiveness of an out-of-school diabetes prevention program for youth (ages 7-15) with a family history of pre-diabetes or type 2 diabetes.

the insulin superheroes club (isc) is based on the diabetes prevention program for adults (knowler wc et al., 2002), which was developed by the centers for disease control and prevention (cdc). we have adapted the curriculum for youth to serve a supplement to the adult program. this program lasts 12 months, and the goals are to improve participants' health and reduce their risk of developing pre-diabetes or type 2 diabetes. the isc program includes 16 weekly (phase 1), 3 bi-weekly (phase 2), and 6 monthly (phase 3) sessions. sessions include 60 minutes of physical fitness and 30 minutes of education. the education portion includes interactive teaching of a health-related topic (e.g., nutrition, exercise, physiology, mindfulness, and stress reduction) using a hand-on learning activity (e.g., cooking, crafts, games, and role play). all physical fitness activities incorporate moderate intensity exercises (e.g., push-ups, yoga, basketball, tag, and dance).

Eligibility criteria:
inclusion criteria * between 7-15 years old * parent or grandparent with pre/type ii diabetes * able to participate in physical activity * parent or caregiver participation exclusion criteria * pregnant females * those with significant physical or mental health illness that would hinder study participation * medications that would interfere with testing results

Keywords: children teens adolescents type 2 diabetes impaired glucose tolerance exercise nutrition education
effect of clopidogrel loading and risk of pci

Conditions: Coronary Artery Disease; Drug Resistance

Summary: this study is a prospective, single-center evaluation of the impact of the variability in platelet response after loading with clopidogrel on the peri-interventional risk of patients undergoing pci.

background: platelet responses after loading with clopidogrel are highly variable. the impact of this variability on the peri-interventional risk of patients undergoing pci has not been investigated prospectively. objectives: our prospective study test the hypothesis that the 30-day clinical outcome of elective percutaneous catheter intervention (pci) differs between strata defined by quartiles of platelet aggregation after loading with 600mg of clopidogrel. further on we will investigate impact of the variability in platelet response on long-term outcome after pci. methods: our study will include consecutive patients undergoing elective coronary stent placement. before pci, patients receive a loading dose of 600mg of clopidogrel followed by 75mg daily. primary end point is the 30-day composite of death, myocardial infarction and target lesion revascularization (mace). platelet aggregation was assessed immediately before pci by optical aggregometry (5µmol/l adp). sample size calculation was based on isar-react which comprised a cohort with similar selection criteria and treatment strategy. thus, we assume an incidence of the primary end point of 4.2%. we design our study to test the hypothesis that the incidence of the primary end point differed by quartiles of adp-induced platelet aggregation. we intend to have a power of 0.80 to detect an effect size of 0.015 (for example 3-fold risk in 4th quartile) with a 2-sided p-value less than 0.05. with these assumptions we obtain a sample size of at least 748 and aime for a cohort of 800.

Eligibility criteria:
inclusion criteria: * patients undergoing elective coronary stenting * pretreatment with a bolus dose of 600mg of clopidogrel prior to coronary stent implantation * pretreatment with aspirin ≥ 100 mg per day for at least 7 days * age \> 18 years * written consent exclusion criteria: * troponin t on admission \> 0.03 ng/ml * myocardial infarction or fibrinolytic therapy within the previous 14 days * cardiogenic shock * contraindication for aspirin or clopidogrel * oral anticoagulation * pretreatment with heparin or a thienopyridine within the previous 14 days * use of a gp iib/iiia-receptor antagonist during pci * platelet count \< 100.000/µl * severe disorders of the coagulation system * severe impairment of liver or kidney function * cancer

Keywords: clopidogrel coronary artery disease dose-response relationship, drug drug resistance pci
pecs i block for breast subpectoral implant surgery

Conditions: Pain, Postoperative

Summary: breast augmentation surgery can cause important postoperative pain, especially when bilateral subpectoral implants are used. the investigators hypothesized that a technique of regional analgesia, the pectoral nerve block type i (or "pecs i block") would reduce pain within the first twenty-four hours and, in turn, morphine consumption and associated side effects. this is a randomized, controlled, double-blind study which compares intra and postoperative analgesia with or without pecs i block in breast surgery.


Eligibility criteria:
inclusion criteria: * every female who will benefit of a bilateral subpectoral breast augmentation * age more than 18 years * social insured exclusion criteria: * refusal of the patient * age less than 18 years * inability to consent * history of thoracic surgery or breast implants * pregnancy * inability to use a patient controlled analgesia * contraindication of the use of opioids or local anesthetics * pathology of hemostasis, infection * can not use a pca * patients under long-term opioids (who pain ladder 2 and 3) * patient presenting neuropathic pain during the preoperative period (score greater than or equal to 4 to the dn4 questionnaire, or taking anti-epileptic or antidepressant treatments for neuropathic pain)

Keywords: pecs block, pectoral block, breast augmentation
effectiveness and safety of nivolumab in participants that have head and neck cancer that has come back or has spread

Conditions: Cancer of Head and Neck; Cancer of the Head; Cancer of the Neck

Summary: non-interventional study in japan of participants with hnc recurring or that has spread and who are treated with nivolumab


Eligibility criteria:
inclusion criteria: * recurrent/metastatic hnc patients with disease progression on or after a platinum-based therapy treated with nivolumab at least once from 01-jul-2017 through 31-dec-2017 exclusion criteria: * history of participation in any clinical trials prior- or post-nivolumab treatment other protocol defined inclusion/exclusion criteria could apply
study of hucns-sc cells in patients with infantile or late infantile neuronal ceroid lipofuscinosis (ncl)

Conditions: Neuronal Ceroid Lipofuscinosis

Summary: patients with infantile or late infantile ncl have either a reduced amount of, or are missing, the palmitoyl protein thioesterase 1 (ppt1) enzyme or the tripeptidyl peptidase 1 (tpp-i) enzyme. human central nervous system stem cells (hucns-sc) are an investigational product derived from human brain cells. hucns-sc have been shown to survive and migrate within the brains of mice. when grown in the laboratory, hucns-sc have been shown to produce the ppt1 and tpp-i enzymes. in mice missing the ppt1 enzyme, hucns-sc have been shown to increase the amount of this enzyme in the brain, to reduce the amount of abnormal storage material in the brain, and to prevent the death of some neurons (a type of cell) in the brain. participation in this study will involve screening assessments, surgery to implant hucns-sc, medication to suppress the immune system, and a series of follow-up assessments. the length of time from the start of screening through to the last follow-up visit will be approximately 13 months, with frequent visits to the study center during this time. after completion of this study, patients will be monitored for an additional 4 years under a separate long term follow-up protocol.


Eligibility criteria:
inclusion criteria: patients may be eligible to participate in this research study if they: * are age 18 months to 12 years old * have a clinical diagnosis of infantile neuronal ceroid lipofuscinosis (incl) or late infantile neuronal ceroid lipofuscinosis (lincl) * have a mutation of the cln1 or cln2 gene * have severe cognitive, communication, behavior and language impairment exclusion criteria: patients may not be eligible to participate in this research study if they: * have cognitive, communication, behavior and language function less than that of a 1 year old * have previously received an organ, tissue or bone marrow transplantation * have previously participated in any gene or cell therapy study * have infection with hepatitis virus, cytomegalovirus, epstein barr virus, or human immunodeficiency virus (hiv) * have a current or prior cancer * have a bleeding disorder * are unable to have an mri scan

Keywords: ncl incl lincl batten disease infantile neuronal ceroid lipofuscinosis (incl) late infantile neuronal ceroid lipofuscinosis (lincl)
patients' satisfaction in thoracic surgery inpatients

Conditions: Thoracic Diseases

Summary: patient satisfaction is considered a subjective indicator of the quality of care provided during a hospital course. identifying the factors that affect patient satisfaction across remains essential. recognizing the growing importance of this metric in assessing medical performance, this study aimed to evaluate the satisfaction and associated factors among inpatients of the thoracic surgery unit of a tertiary care government hospital in nepal.

a cross-sectional analysis of satisfaction levels was conducted among 122 patients consecutively admitted to the thoracic surgery unit. data were collected by interview using a questionnaire of 23 domains scored on a 4-point likert scale, adapted from the health consumer assessment of healthcare providers and systems (hcahps) survey. descriptive and inferential statistics (independent t-test and chi-square test) were used for data analysis.

Eligibility criteria:
inclusion criteria: * all patients (or the guardian if the patient was less than 18 years, or could not consent for some reason) admitted to the study site during the study period exclusion criteria: * refusing to participate, who were hospital staff or their close family members, and those who could not be contacted for interview
orthopedic oncology surgery: navigation, intraoperative imaging and virtual reality

Conditions: Neoplasms; Muscle Neoplasm

Summary: noninterventional, prospective study of patients operated on for musculoskeletal neoplasms designed to evaluate the quality of surgical margins achievable with the use of navigated intraoperative ct


Eligibility criteria:
inclusion criteria: * age: no limit * patients with musculoskeletal neoplasms predominantly in complex sites * patients who will have to undergo surgical resection/amputation for the management of their clinical case * preparation of preoperative planning discussed at dmt * surgery performed with the aid of intraoperative ct navigated * written informed consent exclusion criteria: - inability to perform pre-post treatment assessment
rwe on patients with mpdac long-term survival after treatment with liposomal irinotecan

Conditions: Pancreatic Cancer Metastatic

Summary: the objective is to describe mpdac patients still alive one year after the first cycle of nal-iri

the objectives on patients still alive one year after the first cycle of nal-iri : * characterize mpdac patient population according to their demographics * identify pdac treatment by line of treatment from diagnosis to last treatment * explore prognostic factors of longer overall survival (os) and progression free survivor (pfs) among mpdac patients showing long-term survival

Eligibility criteria:
inclusion criteria: * age ≥ 18 years (≥ 19 years in south korea) * cytologically confirmed mpdac at initiation of the nal-iri treatment * all patients receiving a nal-iri + 5-flurouracil/leucovorin regimen should have been pre-treated with a gemcitabine-based regimen * initiation of a systemic therapy with nal-iri (index date) during the study eligibility period (between january 1, 2018, and december 31, 2021) * at least one cycle of nal-iri-containing regimen should have been administered * a minimum 1-year survival from the index date (initiation date of nal-iri-containing regimen) * availability of data related to survival outcomes in the patient medical record * patients deceased or not at the time of enrollment will be eligible for inclusion in the study exclusion criteria: * no documentation of systemic therapy outcomes or prior treatments in patient medical records * patients with second concomitant metastatic malignancy
excimer light(308) therapy for resistant alopecia areata

Conditions: Alopecia Areata

Summary: this study aimed to evaluate the efficacy and safety of the 308-nm excimer lamp in resistant aa treated with topical minoxidil .

alopecia areata (aa) is a chronic, nonscarring, t-cell mediated autoimmune disease, presenting with localized or diffuse hair fall in hair-bearing areas. approximately 1.7% of the population experience an episode of aa during their lifetime. both sexes are equally affected, and most new cases are recorded below the age of 30 years . excimer laser using high-dose monochromatic uv radiation can trigger apoptosis and induce immunological suppression through altering cytokine production such as il-4, il-10, prostaglandin e2, platelet-activating factor, and cis-urocanic acid. benefits have only been seen with localized patches of aa, and regrowth of hair occurs only in treated areas .

Eligibility criteria:
inclusion criteria: * ● having multiple patches of aa. * duration of alopecia \>1 year * no topical or systemic treatment for the last 4 months * agreement to regular visits for treatment and follow-up. exclusion criteria: * ● a single form of aa. * alopecia for \<1 year. * being on other modalities of treatment. * treatment within the last 4 months. * photosensitive disorders. * pregnancy or breastfeeding.

Keywords: excimer light
self-compassion and nutrition (scan) study

Conditions: Obesity; Weight Loss

Summary: the purpose of this study is to examine the feasibility of two approaches for improving long-term weight loss success among individuals with severe obesity. all participants will receive a 15-week, standard behavioral weight loss program followed by either 8 weeks of a mindfulness self-compassion intervention or 8 weeks of a nutrition and cooking education intervention (determined via randomization procedures). assessments of weight, physical activity, and other weight-related and psychosocial factors will occur at baseline, 4 months, 6 months, and 9 months.


Eligibility criteria:
inclusion criteria: * age 18-65 years * bmi between 40 - 55 kg/m2 * female * score high on internalized weight bias exclusion criteria: * presence of any condition that would limit one's ability to exercise (i.e., orthopedic limitations) * recent weight loss (≥15 pounds within the past 6 months) * history of bariatric surgery * current or recent enrollment (completed \<1 year ago) in a weight loss program at the weight control and diabetes research center * currently taking any weight loss or other medication that could alter one's metabolism * women who are pregnant, planning on becoming pregnant in the next 6 months, or those pregnant within the past 6 months * serious psychiatric disorder (e.g., psychosis, major depression, suicidality) - * participants with a history of diabetes or heart disease will be considered for this study only if their heart disease or diabetes is well controlled, and physician consent will be required.

Keywords: self-compassion exercise nutrition physical activity
icnbs for post-op pain in breast surgery

Conditions: Pain, Postoperative; Length of Stay

Summary: the authors will conduct this study to analyze the effectiveness of peri-operative intercostal nerve blocks (icnbs) in reducing acute postoperative pain after reconstructive breast surgery and mammoplasty and how it affects the length of hospital stay.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists classification (asa class) 3 and below. * bilateral or unilateral breast surgery including cancer extirpation, reconstruction (implant and expander), oncoplastic surgery (\<200 gm), breast augmentation and breast reduction, etc. exclusion criteria: * patients who refuse local anesthesia. * patients who cannot receive local anesthesia. * below the age of 20 and above the age of 70. * patients requiring reoperation due to complications of mammoplasty or another breast surgery. * poorly controlled diabetics, uncontrolled hypertension, heart disease, arrhythmias, diagnosed with bipolar and generalized anxiety disorders.

Keywords: icnb pain
improved otologic implants on demand intraoperatively with 3d cad/cam autografts

Conditions: Middle Ear Disease

Summary: prospectively analyze the use of 3d subtraction cad/cam in the operating room environment. study participants, requiring middle ear surgery and ossicular reconstruction, will be implanted with one of two middle ear implants. the rationale is to complete a pilot study of the technology with a small number of designs. each implant will be commonly used, in the public domain, and recreated by the cad/cam software.

conventional middle ear prosthetic prosthetics, including total ossicular replacement prostheses (torps) and partial ossicular replacement prostheses (porps) are expensive, require large inventories for otologic surgery services, and carry the risk of extrusion or rejection. autologous bone and cartilage can be used for many of these applications, but it requires expensive operating room time for carving to the appropriate shape and size. the above considerations led to the concept of subtractive 3d cad/cam (computer assisted design/computer assisted manufacture) to produce accurate bone and cartilage autografts on demand in the operating room. such a technology is hypothesized to save money by reducing operating room time, and reducing the need for expensive inventories of various shapes, sizes, and types of prosthetic devices. since autologous materials are hypothesized to be less likely to extrude or cause other problems such as infection, this could also reduce costs.

Eligibility criteria:
inclusion criteria: * at least 18 years of age with middle ear disease requiring surgical ossicular reconstruction exclusion criteria: * congenital anomalies