real-time fmri to enhance interventions that change delay discounting

Conditions: Alcohol Use Disorder (AUD)

Summary: the investigators will use real-time fmri neurofeedback to enhance participants' ability to control their temporal window, and hence their ability to modulate delay discounting and alcohol valuation.

based on 8 years of experience recruiting alcohol users into studies of comparable length and complexity, the investigators anticipate that 92% of consented participants will be eligible (i.e., randomized) and 97% of those individuals will complete aim 2b. thus, to achieve a final sample size of 100, the investigators anticipate consenting 111 participants. this study will include 50 real time fmri (experimental group) participants and 50 "idealized" neurofeedback (control) participants. participants will be randomly assigned to experimental or control groups, stratified by audit scores, ses, age, and sex. all study procedures will take place during a single study visit. before the imaging session, a research assistant will aid the participant to select salient images related to individualized future goals as well as alcohol images which elicit self-reported craving. all participants will complete two fmri runs within a single session. in run 1 of the scan (offline classifier training), participants will perform an image viewing task displaying alternating blocks of these goal- and alcohol-related images. between the image viewing blocks we will assess reinforcer pathology with brief in-scanner measures of delay discounting and alcohol valuation (baad). in total, there will be six blocks each of the goal-oriented images, alcohol-related images, delay discounting, and baad (24 blocks total). since this is a proof-of-concept experiment, the interspersed delay discounting and baad blocks will enable monitoring and validating changes in the participant's temporal window and alcohol valuation after the image viewing blocks. only the fmri measures of goal- and alcohol-related image viewing will be used to build a support vector classifier (svc) of decreased vs. increased delay discounting. if participants are allocated to the real time fmri group, in run 2 the svc model from run 1 will be used to provide participants with real-time neurofeedback while they attempt to modulate their temporal window. the participants will see a dial with a needle on the screen along with instructions to think of either future goals or alcohol cues. the dial will be directly controlled by ongoing output from the svc, updating the needle position as participants imagine immediate (alcohol-related) or delayed (goal-related) cues. control participants ("idealized" neurofeedback group) will undergo the same procedures, but in run 2 neurofeedback, will be presented with an "idealized" dial (perfect needle movements in both alcohol and goal directions) and will be specifically instructed that they are not controlling the interface. the investigators have used this type of sham needle movement as a control condition in previous experiments. based on this, it is expected that experimental group will have increased whole brain signal to noise for alcohol vs. goal fmri analyses and increased recruitment of frontal-parietal networks from enhanced visual attention to the task.

Eligibility criteria:
inclusion criteria: * demonstrate high-risk or harmful drinking (audit\>15) * be 21 years of age or older * have a desire to quit or cut down on their drinking, but do not have proximate plans to enroll in treatment for aud during the study period exclusion criteria: * meeting moderate to severe dsm-5 criteria for substance-use disorders other than alcohol or nicotine * having a current diagnosis of any psychotic disorder * having a history of seizure disorders or traumatic brain injury * having any contraindication for participation in the mri sessions * reporting current pregnancy or lactation

Keywords: alcohol use disorder (aud) rt-fmri behavioral economics