Kornimate/medical-research-clean huggingface dataset:
airway and pulmonary vascular endothelial function in healthy smokers: effect of inhaled glucocorticosteroid treatment

Conditions: Smoking

Summary: the purposes of the present proposal are to 1) compare inhaled albuterol-induced changes in airway blood flow (qaw), and in co and ppas in healthy current smokers and lifetime non-smokers as an index of endothelial function in the airway and pulmonary circulations, 2) compare the results between smokers and non-smokers, and 3) determine the effect of a 4-week treatment with an ics on albuterol responsiveness of qaw and the echocardiographic parameters. with this protocol the investigators will test the hypotheses that a) there is a correlation between airway and pulmonary vascular endothelial function within the current smoker and non-smoker groups, and b) ics treatment improves airway and pulmonary vascular endothelial function in the current smoker group.

with this protocol the investigators will test the hypotheses that a) there is a correlation between airway and pulmonary vascular endothelial function within the current smoker and non-smoker groups, and b) ics treatment improves airway and pulmonary vascular endothelial function in the current smoker group. fifteen healthy current smokers with a \>10 pack-year history of smoking and 15 healthy never-smokers will be enrolled. males and females between 25 and 75 years of age will be recruited there will be 1-4 visits to the laboratory (one for non-smokers, 4 for smokers). all subjects will have the first visit. current smokers will have 3 additional visits. current smokers will be asked not to smoke before coming to the laboratory on the 3 study days. all subjects will be instructed to abstain from ingesting alcoholic beverages, coffee or caffeinated drinks for at least 12 hours the night before each study day. the subjects will also be instructed not to use pde5 inhibitors for 24 hours before coming to the laboratory. on each study day, the protocol will start at the same time (in the morning).

Eligibility criteria:
inclusion criteria: * fifteen healthy current smokers with a \>10 pack-year history of smoking and 15 healthy never-smokers will be enrolled. males and females between 25 and 75 years of age will be recruited. exclusion criteria: * women of childbearing potential who do not use accepted birth control measures; pregnant and breast feeding women * cardiovascular disease and/or use of cardiovascular medications * subjects with known beta-adrenergic agonist intolerance * a physician diagnosis of chronic airway disease (asthma, copd, bronchiectasis, cystic fibrosis) * acute respiratory infection within four weeks prior to the study * use of any airway medication * abnormal pulmonary function

Keywords: smokers airway blood flow fluticasone echocardiogram
is high sensibility troponins a dialysable marker in hemodialysis patients and does it have prognostic value?

Conditions: Renal Failure

Summary: evaluation of high sensibility troponin levels modification by hemodialysis in terminal renal failure patient at sherbrooke university hospital center as determined by serial measurements. verification of potential effects of these levels and their variation as predictors of cardiovascular outcomes and events at 6 and 12 months.

recruiting of hemodialysis patients of the nephrology renal supplementation clinics at sherbrooke university hospital center to measure three blood level of high-sensibility troponins before and after standard dialysis. verification on the variation of these levels after dialysis. follow-up at 6 and 12 months of the patient for cardiovascular events and death and verification of a possible predictive value of troponin blood levels for these events.

Eligibility criteria:
inclusion criteria: * over 50 years, no symptoms, over 1 months of hemodialysis exclusion criteria: * 1 or more in the last month; acute coronary syndrome, heart failure decompensated, myo or pericarditis, pulmonary embolism, sepsis/shock, stroke or transient ischemic attack, malignant high blood pressure, arrythmia, electrical cardio-version, major trauma, significant burnings (\>25%), chemotherapy, cardiovascular surgery, percutaneous angio-intervention, * chronic systemic disease (sarcoidosis, amyloidosis, led, etc.)
persistent postoperative pain and joint stiffness after total knee arthroplasty performed for osteoarthritis

Conditions: Pain; Joint Stiffness

Summary: persistent pain and joint stiffness after surgery may interfere with recovery and adversely affect quality of life in up to 40% of patients who have undergone total knee arthroplasty. there is growing evidence that inflammation as well as other medical and psychological factors may be associated with osteoarthritis severity, progression, and associated pain severity. this study aims to identify clinical, biological, and psychological factors that contribute to and predict the development of these complications. identification of such factors may allow us to target preventative measures to the patients at highest risk of persistent postoperative pain and joint stiffness.


Eligibility criteria:
inclusion criteria: * elective primary unilateral total knee arthroplasty * osteoarthritis with radiologic evidence of "severe narrowing" and/or "bone on bone" in the affected joint * patients of surgeons who have agreed to participate in the study * age \> 18 years * american society of anesthesiologists (asa) physical status 1-3 * regional anesthesia * epidural patient-controlled analgesia (pca) for postoperative pain * adductor canal block for postoperative pain exclusion criteria: * contraindication to regional anesthesia, nsaids, dexamethasone or acetaminophen * use of general anesthesia * history of \>6 weeks of daily opioid use and/or any use of non-prescribed opioids * preoperative oral steroid use in the past 6 months * intra-articular steroid injection within one month of scheduled surgery in affected joint * non-english speakers * pre-existing diagnosis of rheumatic disease or autoimmune disease (e.g. rheumatoid arthritis, psoriatic arthritis, inflammatory bowel disease, multiple sclerosis, type i diabetes) * peri-articular injections or infusions for postoperative pain * diagnosis of crystalline arthropathy * diagnosis of osteonecrosis * active infection or use of antibiotics * pregnant women

Keywords: cytokines
advanced mri applications development

Conditions: Brain Tumors

Summary: the goals of this study are to: 1. to improve upon and develop new innovative magnetic resonance imaging techniques that refine image quality and enhance performance. improvements in these areas will have positive implications for medical diagnosis and treatment. 2. to correlate mri images with underlying disease pathophysiology in order to ensure that imaging accurately reflects the disease process.


Eligibility criteria:
inclusion criteria: * brain tumor exclusion criteria: * unable to undergo mri
efficient, holistic, heuristic and semi-structured suicide assessment tool (ehssa) - very accurate prediction of risk.

Conditions: Suicide Risk

Summary: many studies have found that insights regarding suicide risk-factors for cohorts does not translate to practical value in the identification of such risk in specific individuals. e.h.s.s.a. - a suicide assessment tool that was empirically designed by an emergency psychiatry department (p.e.s.p. of bergen county) in its effort to accurately predict, in specific patients, the risk of suicide attempts in the reasonably foreseeable future. it is of a unique paradigm that combines critical elements of holism, heuristics and semi-structured design.

objective: many studies have found that insight regarding suicide risk-factors for cohorts does not translate to practical value in the identification of such risk in specific individuals. this performance improvement study formally examined the effectiveness of "ehssa" (efficient, holistic/heuristic semi-structured suicide-risk assessment) - an empirically derived tool designed by this emergency psychiatry department. it is a suicide assessment tool for predicting in a specific patient (as opposed to a cohort), the risk of serious suicide attempts in the reasonably foreseeable future. methods: at p.e.s.p. (psychiatric emergency screening program) of bergen county of new jersey, a prospective performance improvement study was done on all patients (n = 1,505) that had presented with psychiatric crisis to the department over the course of a 6 month period, (of which approximately 50% had significant suicidal ideations). the only exclusionary criteria was active delirium. each patient was evaluated using "ehssa" by departmentally trained mental health professionals. patients were deemed to either require hospitalization or be safe to be discharged to the community (with appropriate outpatient referrals). those that were discharged (n = 137) were followed up with phone calls approximately 15 days post discharge.

Eligibility criteria:
inclusion criteria: * patients of any age/gender/economic class with or without dementia and/or substance use disorders * all patients presenting to p.e.s.p.(psychiatric emergency screening program of bergen county) in psychiatric distress/crisis. exclusion criteria: - active delirium.

Keywords: suicide risk assessment tool holistic heuristic semi-structured predictive capacity
lift: telemedicine breastfeeding support

Conditions: Breastfeeding

Summary: the central hypothesis guiding this project is that tailored breastfeeding support, that leverages easily accessible telemedicine technologies, can improve breastfeeding outcomes among late preterm dyads. the long-term goals of this project are to improve maternal and child health and reduce health disparities by designing and implementing evidence-based interventions to improve breastfeeding outcomes for this challenging patient population. this study seeks to identify lactation support practices that improve breastfeeding duration and to test the effect of telemedicine breastfeeding support on breastfeeding duration, among the nearly one in ten mothers who deliver late preterm (34-37 6/7 weeks), as this subpopulation of mothers faces the highest rates of premature breastfeeding cessation


Eligibility criteria:
inclusion criteria: * maternal age 18-49 years * late preterm delivery (34-37 6/7 weeks) * enrollment up to 1 week postpartum * breastfeeding initiated * access to a smartphone, tablet, or laptop computer in their home exclusion criteria: * incarceration * inability to communicate in english * infant with medical condition compromising breastfeeding (e.g. cleft lip and/or palate).
multimodal managements for metastatic pancreatic cancer.

Conditions: Metastatic Pancreatic Cancer

Summary: pancreatic ductal adenocarcinoma (pdac) remains a challenging malignancy, with over 300,000 patients diagnosed annually worldwide. patients with metastatic pancreatic cancer (mpc) are generally not considered appropriate for operative management because it would not improve their prognosis. developments in modern surgery and systemic treatment over the past decade have substantially improved the oncological outcomes for patients with pdac. the prognosis can be further improved by using novel combined regimens. systemic treatment is advantageous as it allows biological selection of patients and control of systemic lesions in patients with pdac with only hepatic metastases (hep-mpc), which may increase the likelihood of radical tumor resection and improved survival. therefore, there is a strong need to reassess the value of surgery in hep-mpc. locoregional liver-directed treatments (lldts) are safe and efficient methodologies and have thus become the standard of care for patients with metastatic colorectal cancer (mcc) with liver-only or liver-dominant metastases. lldt therapies include local liver resection, radiofrequency ablation (rfa), hepatic artery infusion pump chemotherapy (haip), stereotactic body radiation therapy (sbrt), and selective internal radiation therapy with yttrium-90 embolization (y90). these therapies have been reported to influence the overall survival (os), progression-free survival (pfs), and conversion to resection in patients with metastatic colorectal cancer. however, the data on the survival outcomes of conversion surgery and the clinical application of lldt in hep-mpc are sparse. therefore, it remains unclear what types of treatment, based on the survival benefit, might actually be the optimal approach for hep-mpc after effective systemic treatment. the present study aims to clarify the selection criteria of conversion surgery for hep-mpc and explore the prognostic significance for its multimodal management, including surgical resection and/or lldt.


Eligibility criteria:
inclusion criteria: * adult patients aged ≥18 years (at diagnosis). * cytologically or histologically confirmed pancreatic adenocarcinoma. * synchronous liver metastatic disease (at diagnosis). * no evidence of extrahepatic metastases (at diagnosis.) * eastern cooperative oncology group (ecog) performance status (ps) 0-2. * eligible for multimodal treatment. exclusion criteria: * multi-organ metastatic pancreatic cancer. * contraindications to surgical resection or systemic treatment. * inability to participate in follow-up assessments. * history of other malignancies. * refusal of treatment.
intense monitoring study on tyvyt

Conditions: Relapsed or Refractory Classical Hodgkin's Lymphoma

Summary: the study is a multi-center, prospective, non-interventional and observational study, and will collect data on the safety and efficacy of tyvyt® in the treatment of chinese patients with relapsed or refractory classical hodgkin's lymphoma.


Eligibility criteria:
inclusion criteria: patients must be able to understand and voluntarily sign the informed consent form (icf). patients must provide reliable contact information, including home phone numbers or follow-up phone number, and be voluntary to be followed up. patients must have agreed to use tyvyt® to treat the target indication. exclusion criteria: patients refuse to be included in the study or refuse to cooperate. patients have participated in another interventional studies within 4 weeks prior to enrollment.
consequences of covid-19 on the psychological and physical health of the nursing staff and on their professional activity.

Conditions: Work-related Illness

Summary: the aim of this research is to identify the consequences of the covid-19 on the physical and psychological health of the nursing staff of the intercommunal hospital of villeneuve-saint-georges and on their professional activity thanks to a self-questionnaire. this anonymous self-questionnaire is intended for all the chiv care workers who were infected by the coronavirus during the first wave and identified by the occupational health service.

the covid-19 pandemic has had an important impact in the world, in france, it has put our health system under tension. we know that a health crisis of this magnitude can induce psychological and physical disorders, particularly in exposed caregivers. systematic occupational medicine consultations of all medical and paramedical personnel, whether tenured or not, working at the villeneuve saint georges hospital (chiv) who presented a covid-19 between february 1 and june 30, 2020, allowed us to note the presence of multiple after-effects. the present study evaluates the consequences of the disease on the physical and psychological health of these caregivers and on their professional activity.

Eligibility criteria:
inclusion criteria: 1. major patient 2. part of the medical and paramedical staff working at the chiv, 3. having been reached by covid-19 during the first wave, between february 1st and june 30th 2020. 4. patient affiliated to a social security system exclusion criteria: * none
efficacy and safety of leo 43204 in field treatment of actinic keratosis on face or chest including 12-month follow-up

Conditions: Actinic Keratosis

Summary: the objective of the trial is to compare the short term efficacy of leo 43204 gel with vehicle gel in ak on face or chest when applied topically once daily for 3 consecutive days as field treatment.


Eligibility criteria:
inclusion criteria: * subjects with 5 to 20 clinically typical, visible and discrete aks within a treatment area of sun-damaged skin on either the full face or a contiguous area of approximately 250 cm2 (40 in2) on the chest * subjects with minimum 3 clinically typical, visible and discrete aks within a tracking area of 50 cm2 (8 in2). the tracking area must be within the treatment area exclusion criteria: * location of the treatment area (full face or chest) within 5 cm of an incompletely healed wound or within 5 cm of a suspected bcc or scc * treatment with ingenol mebutate gel in the treatment area within the last 12 months * lesions in the treatment area that have: atypical clinical appearance (e.g. hyperthrophic, hyperkeratotic or cutaneous horns) and /or, recalcitrant disease (e.g. did not respond to cryotherapy on two previous occasions) * history or evidence of skin conditions other than the trial indication that would interfere with the evaluation of the trial medication (e.g., eczema, unstable psoriasis, xeroderma pigmentosum)
dexamethasone for post cesarean delivery analgesia

Conditions: Postoperative Pain

Summary: the purpose of this study is to assess the effectiveness intravenous (iv) dexamethasone when used as part of a multimodal regimen to manage post cesarean delivery pain. we hypothesize that a single dose of iv dexamethasone administered, as part of a multimodal analgesia after spinal anesthesia will significantly reduce post cesarean delivery opioid consumption and pain

after the subjects consent to participate in the study they will be transferred to the operating room for their scheduled cesarean delivery. they will have their routine spinal anesthesia with the dosages of drugs used standardized, and a standardized regimen to manage hypotension. after delivery of the baby the subjects will be administered either the study drug or placebo depending on the randomization. the subjects will then be prescribed a standard post-operative analgesia regimen. the subjects will then be interviewed at 12,24 and 48 hours post cesarean delivery. during the interview the subjects will be asked to rate their pain, nausea and vomiting and pruritus. they will also be asked to rate their quality of recovery from the surgery using quality of recovery-40 questionnaire. the subjects will be contacted 6 months after the study to rate their pain using a short-form mcgill pain questionnaire

Eligibility criteria:
inclusion criteria: * english speaking * non-laboring women * scheduled elective cesarean section under spinal anesthesia * american society of anesthesiologists i-ii physical status exclusion criteria: * contraindications to spinal anesthesia * allergy to study medication * patients with allergy to morphine * patients with uncontrolled hypertension * history of peptic ulcer disease * liver cirrhosis * diabetes mellitus * glaucoma * known iv drug abusers * patients with chronic pain or on long term opioids * patients administered steroids in the past week * women with fetuses having known congenital abnormalities * psychiatric illness such that they are unable to comprehend or participate in study questions * patients on antiviral medications or live virus vaccines would also be excluded.

Keywords: cesarean delivery analgesia pain dexamethasone intrathecal morphine spinal anesthesia
glutamine with topical corticosteroids for lichen planus treatment

Conditions: Lichen Penis Planus

Summary: lichen planus (lp) is an inflammatory skin disease of unknown etiology. glutamine promotes protein and collagen synthesis, imparts immunity, and maintains the alimentary canal mucosa structure.

lichen planus (lp) is an inflammatory skin disease of unknown etiology. recently, increased oxidative stress has been implicated in the pathogenesis of erosive oral lichen planus (eolp). glutamine is a source of energy for fibroblasts, immunocompetent cells, and intestinal epithelial cells involved in collagen production. it promotes protein and collagen synthesis, imparts immunity, and maintains the alimentary canal mucosa structure. the aim of this study is to evaluate the effect of glutamine combined with topical corticosteroid in the treatment of oral erosive lp. thirty patients with a confirmed clinical and histopathologic diagnosis of olp recruited in this study and divided into 2 equal groups, each consisting of 15 subjects. group 1 consists of patients treated with topical steroids plus antifungal (conventional therapy); group 2 consists of patients treated with glutamine combined with topical steroids plus antifungal.

Eligibility criteria:
inclusion criteria: 1. patients clinically and histopathologically diagnosed to be suffering from eolp. 2. patients who had symptoms i.e. pain and/or burning sensation secondary to eolp. 3. patients under stressful life conditions as evidenced by isma-uk stress questionnaire 4. males and females with an age ranging from 30-60years exclusion criteria: 1. patients suspected to have a lichenoid drug reaction or lichenoid contact allergy. 2. patients suffering from any systemic diseases (such as diabetes, cardiovascular, liver disorder, renal dysfunction) 3. patients with findings of any physical or mental abnormality which would interfere with or be affected by the study procedure.