Kornimate/medical-research-clean huggingface dataset:
different treatments in chronic pain patients.

Conditions: Chronic Pain; Nociplastic Pain

Summary: the goal of this observational study is to compare different treatment options in a chronic pain population. the main questions it aims to answer are: * what is the effectiveness of the different therapy options in the pain center of sint-lucas on outcomes related to pain and disability? * what are predictive factors for the different therapy options in the pain center of sint-lucas? which factors predict improvement in pain related outcomes? participant data will be gathered as part of their routine care. they can be advised to 4 different treatment options: * consultations with the pain specialist * interventions by the pain specialist (infiltrations, denervations) * baxter therapy * interdisciplinary treatment researchers will compare patients with different dominant pain mechanisms to see which treatment are most effective for which dominant pain mechanisms.

the aim of the present study is to describe the natural flow of the chronic pain patients at the pain center az sint-lucas. patients will be examined before starting the therapy, and receive standardized questionnaires at several fixed time points (before, during, and after their therapy trajectory). information about the present dominant pain mechanism will be gathered during the examination. the questionnaires will gather demographic data, information about the present dominant pain mechanism, psychosocial factors, catastrophizing, fear and avoidance, illness perceptions, fatigue and information about therapy success. during the examination, typical signs of a dominant nociplastic pain mechanism will be gathered. by processing the data of the questionnaires and the examination, knowledge about (1) the amount of patients with a dominant nociplastic pain mechanism at intake, (2) the treatment trajectory for a specific diagnosis, and (3) the prediction of the therapy effect and prognosis will be obtained.

Eligibility criteria:
inclusion criteria: * adults * chronic pain patients * dutch speaking, or good understanding exclusion criteria: * adults unable to give consent * adults who do not understand dutch
colchicine treatment for chronic shoulder pain related to calcific tendonitis

Conditions: Calcific Tendonitis

Summary: chronic pain due to calcific tendonitis of shoulder is a prevalent condition usually treated with recurrent courses of nsaids, physical therapy or surgical interventions. colchicine has been reported to be effective in the acute attack of shoulder tendonitis, however, has never been examined in controlled study in patients with chronic shoulder pain secondary to calcific tendonitis. eighty patients with chronic shoulder pain (at least 3 months duration) due to calcific tendonitis will be randomized to receive colchicine 0.5 mg twice daily or placebo (lactose capsules) for 4 months. at the end of this blinded part of the study, patients who received placebo and did not improve, will be eligible to continue study in the open mode for additional 4 months with study drug. efficacy (vas for shoulder pain, shoulder range of motion and shoulder pain and disability index) and safety (blood tests) follow-ups will be scheduled bi-monthly for all patients.


Eligibility criteria:
inclusion criteria: * chronic, more than 3 months duration, shoulder pain * tendinous calcifications on shoulder x-rays exclusion criteria: * renal insufficiency * liver insufficiency * lactose intolerance * hypersensitivity to colchicine
role of ngal in vitiligo

Conditions: Vitiligo

Summary: role of serum neutrophil gelatinase-associated lipocalin in early detection of cardiovascular risk in patients with vitiligo


Eligibility criteria:
inclusion criteria: * patients with vitiligo above 20y exclusion criteria: * patients with systemic disease pregnants female lactating females patients less than 20 y patients with active lesions

Keywords: ngal & cvr
an observational study exploring the esthetic outcomes of breast reduction surgery and /or mastopexy

Conditions: Macromastia

Summary: the purpose of the study is to collect data regarding the aesthetic outcomes of patients who had breast reduction surgery and /or mastopexy in terms such as scaring, patient satisfaction, breast ptosis assessment including taking photographs and filling questionnaires.

this is a prospective observational study, single center cohort to explore the aesthetic outcomes of patients who had breast reduction and / or mastopxy surgery. the surgical intervention will be determined by the clinician with no correlation to this study. the study will focus on the aesthetic aspects of the clinical outcome resultant from the breast surgery in par course of 5 years. scar tissue assessment and patient's reported data (satisfaction and well-being) will be collected. suitable patients will be assessed for study eligibility at a screening visit and, if eligible, will be scheduled for breast surgery according to the patient and surgeon discretion. at each follow up visit, patients will undergo clinical general examination, breast and ptosis endearments, scar appearance , aesthetic evaluation. patients will fill satisfaction questionnaires

Eligibility criteria:
inclusion criteria: 1. female patient older than 30 years of age. 2. patients willing to participate as evidenced by signing the written informed consent. 3. patient that was found by her physician illegible for breast reduction surgery and /or mastopxy exclusion criteria: 1. active psychiatric illness, cognitive or sensory impairment. 2. physical impairment that may prevent filling out a paper and pencil survey or responding to interview questions -

Keywords: breast reduction mastopexy sagging
effects of corticorelin administration on dopamine transmission, craving, and mood in cocaine dependence

Conditions: Cocaine-Related Disorders; Cocaine Addiction; Substance-Related Disorders

Summary: this study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups. dopamine release will be measured using pet neuroimaging with the radiotracer \[11c\]-(+)-phno.

scientific summary the project will, in a sample of cocaine-dependent (cd) and healthy control (hc) subjects, use administration of corticorelin, a synthetic form of corticotropin releasing factor (crf)and pet imaging to assess dopamine (da) transmission in addiction. we will use \[11c\]-(+)-phno pet to measure striatal da receptor binding on two occasions: 1) following corticorelin administration and 2) following saline. the change in receptor binding between the two occasions (i.e., displacement of \[11c\]-(+)-phno by endogenous da) will index da release. subjects cd subjects will meet dsm-iv criteria for abuse or dependence and be \~10d cocaine abstinent at the time of pet. hc will be recruited to match cd on age, sex, education, and cigarette smoking. primary outcome measures we will measure \[11c\]-(+)-phno binding on two occasions (corticorelin, saline), with the difference between conditions indexing dopamine release; this measure will then be compared between cocaine-dependent and control subjects. we will also measure plasma cortisol and acth), physiological measures, and subjective craving and mood.

Eligibility criteria:
inclusion criteria: * sign and date informed consent * willing and able to complete trial as described in the protocol * psychiatrically healthy (as per diagnostic interview) except for cocaine dependence in cocaine users and nicotine dependence in both groups * mentally healthy * medically healthy (as per medical exam) with no current use of medications that may interfere with hormone activity or psychological measurements exclusion criteria: * axis i psychiatric disorder (as per diagnostic interview), or medical condition that might interfere with participation in the study (as per medical exam) * exposure to radiation in the last 12 months exceeding the amount permissible by the camh pet centre * have received synthetic glucocorticoid or exogenous steroid therapy within one month of testing * exceed normal body weight * if female: pregnancy or breast-feeding * metal implants or paramagnetic objects contained within the body * claustrophobia

Keywords: cocaine substance-related disorders drug addiction substance addiction dopamine receptors, dopamine d2 receptors, dopamine d3 stress, psychological corticorelin neuroendocrine system cortisol adrenocorticotropic hormone positron-emission tomography 11c-phno
impact of age on surgical outcome of adolescent idiopathic scoliosis

Conditions: Scoliosis

Summary: this is a study prospectively enrolling adolescent idiopathic scoliosis (ais) patients and try to find how the age will impact the surgical outcome of ais.


Eligibility criteria:
inclusion criteria: * adolescent idiopathic scoliosis patients; undergoing posterior correction surgery; with minimum 5 years follow-up; with full-spine radiography. exclusion criteria: * with spinal tumor; with hip disease; without quality of life measurements.
microcirculation in cardiac surgery

Conditions: Cardiac Disorder

Summary: the purpose of this study is to determine whether cardiopulmonary bypass affects mesenteric microcirculatory function, using sublingual evaluation, in cardiac surgery.


Eligibility criteria:
inclusion criteria: * age\> 18 years old * aortic valvular disease needing aortic valve replacement exclusion criteria: * age\<18 years old * emergent cardiac surgery * other cardiac surgery

Keywords: cardiopulmonary bypass mesenteric microcirculatory function
trunk stabilization exercises affect the activity of the upper limb

Conditions: Stroke

Summary: the aim of the study was to analyze the effect of trunk stabilization exercises on coordinated movement of the affected upper limb in patients after stroke, using the armoe®spring device and the "wall" and "abacus" functional tests. the study group had physiotherapy based on the ndt bobath concept and the control group used classic exercises.

almost half of the stroke patients report impaired function of the upper limb and hand. stability of the trunk is required for the proper movement of the body, including the legs and arms. the aim of the study was to analyze the effect of trunk stabilization exercises on coordinated movement of the affected upper limb in patients after stroke, using the armoe®spring device and the "wall" and "abacus" functional tests. material and method: this is a randomized, double-blinded study. the research was carried out in the rehabilitation clinic on a group of 60 stroke patients who were randomly assigned to groups differing in the rehabilitation program. the study group had physiotherapy based on the ndt bobath concept and the control group used classic exercises. the importance of the trunk for upper limb coordination was assessed on the armeo®spring device using three evaluation programs: "perpendicular hunting"; "horizontal hunting"; "reaction time" and two proprietary tests: "wall" and "abacus".

Eligibility criteria:
inclusion criteria: 1) patients 5 to 7 weeks after ischemic stroke; 2) patients with hemiparesis after stroke; 3) subjects with poor trunk control; 4) subjects who were in a functional state allowing movements of the upper extremity; 5) muscle tension that allows movement; 6) no severe deficits in communication, memory, or understanding what can impede proper measurement performance; exclusion criteria: 1) lack of possibility to adjust the orthosis to the patient's treated limb, 2) bone instability (non-fused fractures, advanced osteoporosis), 3) permanent contracture of the treated limb, 4) open skin lesions in the area of the treated upper limb, 5) sensory deficits, disturbances, 6) shoulder subluxation or pain 7) increased spasticity, 8) increased involuntary movements, e.g. ataxia, dyskinesia, myoclonic seizures, 9) unstable life functions: contraindications related to the respiratory system or the cardiovascular system (instability or the need to use supportive devices), 10) the need for long-term intravenous therapy, 11) postural instability, 12) contraindication to a sitting position, 13) confused or uncooperative patients, 14) severe cognitive impairment, 15) patients requiring isolation due to infections, 16) severe vision problems (the patient is not in the ability to observe the elements displayed on the computer screen), 17) epilepsy.

Keywords: armeo®spring device, ischemic stroke, upper limb, motor coordination, trunk stabilization exercises, ndt bobath concept
multicenter registry on robotically assisted pci - tesla

Conditions: Coronary Artery Disease

Summary: multicenter registry on robotically assisted percutaneous coronary interventions- tesla registry is a retrospective registry evaluating the safety and efficacy of robotically assisted pci with the corpath grx system (corindus vascular, siemens healthineers, germany) in real-world interventional cardiology practice.

r-pci represents a novel approach to performing pci with several studies showing high technical success and low complication rates. the corpath grx system is the second generation of the corpath platform, dedicated to advancing robotic-assisted vascular procedures to mitigate the orthopaedic and radiation-related occupational hazards associated with the practice of interventional cardiology. multicenter registry on robotically assisted percutaneous coronary interventions- tesla registry is a retrospective registry evaluating the safety and efficacy of robotically assisted pci with the corpath grx system (siemens healthineers, germany) in real-world interventional cardiology practice in europe and asia. all patients who underwent r-pci (defined as completion of at least one procedural step robotically) with the corpath grx system and completed one-year follow-up are eligible for recruitment in this registry, if older than 18 years. this study includes patients with either stable coronary artery disease, unstable angina, or acute myocardial infarction (mi). the study investigators expect to enroll at least 700 patients (up to 1000). international centers that performed r-pci with the corpath grx system will be invited to participate in this multicenter study. baseline, procedural, and follow-up data will be collected for all cases.

Eligibility criteria:
inclusion criteria: * older than 18 years, * patients with either stable coronary artery disease, unstable angina, or acute myocardial infarction (mi), * coronary artery lesions considered suitable for r-pci with corpath grx system. exclusion criteria: - unwillingness to provide informed consent (only if applicable).

Keywords: robotically-assisted percutaneous coronary intervention coronary artery disease r-pci registry
effects of non-invasive neuromodulation on food desire, chewing pattern, executive functions and oxidative stress.

Conditions: Craving; Mastication Disorder; Memory Disorders; Executive Dysfunction; Transcranial Direct Current Stimulation; Inflammation; Oxidative Stress

Summary: from the change in self-regulation, memory is inhibited, allowing individuals to suppress or ignore unwanted or outdated associations and thus help to filter information relevant to dietary goals from irrelevant information. provoking changes in neuroplasticity and cortical excitability contribute to the regulation of neural activity. both could be modified by applying direct electrical current to the sensorimotor cortex, with polarity/current-dependent results, and their effect would last for hours after the end of stimulation. transcranial direct current stimulation (tdcs), translated into portuguese as estimulação transcraniana por corrente contínua (etcc) is a neuromodulating tool in which a low-intensity electrical current is applied to the scalp to modulate neuronal activity.


Eligibility criteria:
inclusion criteria: * being a health professional at the hu-ufpi (higher and technical levels); * both sexes; * age between 20 and 59 years old. exclusion criteria: * participants with communication disabilities (outbound or inbound); * type 1 and 2 diabetes * low body mass index (bmi; below 18.5), * intracranial metal clip and/or prostheses; * abrupt change in weight (\> 5 kg) in the last six months; * the use will be excluded recreational use of psychoactive drugs, * being a smoker or using nicotine (tablet / absorbent), * having had significant recent trauma or traumatic brain injury, * present history of epilepsy, * to be pregnant or under suspicion * missing teeth; * medical diagnosis of eating disorder or any psychiatric disorder, * having or having had cancer, * diagnosis of heart disease.

Keywords: craving executive dysfunction oxidative stress transcranial direct current stimulation
karolinska cardiorenal theme-centre and stockholmheartbank

Conditions: Chronic Kidney Disease; Chronic Renal Failure; Acute Coronary Syndrome; Ischemic Heart Disease; Myocardial Infarction

Summary: chronic kidney disease (ckd) affects 10-18% of the adult population and is becoming recognized as one of the most serious disorders causing increased risk for cardiovascular disease and death. in patients with ischemic heart disease 26% have increased creatinine, which rises to 40% if patients also have diabetes mellitus. risk increases as renal function diminishes, and just slowing the rate of decline in renal function would have a tremendous impact on health and morbidity. this association is commonly termed the cardiorenal syndrome, though it is caused by a much more complex interplay between major pathogenetic pathways such as glucose metabolism and diabetes, systemic and tissue inflammation, tissue metabolism, coagulation, mineral metabolism, sympathetic activation, renin-angiotensin-aldosterone system activation, endothelial dysfunction, lipid metabolism, fetal programming etc. karolinska institutet recently merged basic and clinical researchers in all these fields, creating a karolinska kardiorenal theme centre; ultimately aiming to explore the syndrome and provide improved care for the individual patient. the investigators road to success: * creating a biobank (blood, dna, plasma) from the majority of all hosptalized patients with acs in stockholm county - stockholmheartbank. * this theme center include all teaching hospitals associated with karolinska institutet; danderyd university hospital, karolinska university hospital and södersjukhuset university hospital. together theses hospitals serve as emergency hospitals for 1.9 million people. the investigators are aiming at creating a biobank from all patients admitted for an acute coronary event (about 2.300/yr), which is a unique asset for molecular and genetic research as well as observational and intervention studies. * the investigators have access to the national registry with 100% coverage, that contains data on all patients admitted to stockholms coronary care units since 1995. * to ensure translation in to clinical practice, most of the researchers are also md:s, and several are clinically active. * the clinical network facilitates the development of novel therapies and translational research. * steering groups for education and a clinical practice implementation program.


Eligibility criteria:
inclusion criteria: * all patients admitted to one of the four major emergency hospitals in stockholm, for an acute coronary event. * all patients admitted to one of the four major emergency hospitals in stockholm, for an elective coronary angiography exclusion criteria: * severe hemodynamic instability with the need of inotropic therapy and at the same time anemia with haemoglobin \<1.1 g/dl
assessing the benefits of robotic and laparoscopic surgery for mid and low rectal cancer in patients: the charlson comorbidity index (cci)

Conditions: Robotic; Laparoscopic; Anterior Resection for Rectal Cancer

Summary: this retrospective study collected participants who underwent robotic or laparoscopic anterior resection for rectal cancer at the north people's hospital in jiangsu from january 2019 to january 2023.


Eligibility criteria:
inclusion criteria: the criteria include: (1) pathology of low rectal cancer (within 10 cm from the anal margin); (2) access to comprehensive pathological and computed tomography (ct) data; (3) completeness of clinical data. exclusion criteria: patients with other malignant tumors besides rectal cancer, benign disease surgery, and emergency surgery.
consequences and correlates of weight fluctuations

Conditions: Cardiovascular Diseases; Diabetes Mellitus; Heart Diseases; Hypertension

Summary: to quantify the association between multiple intentional weight losses (i.e., weight fluctuations) and the development of hypertension and diabetes mellitus among 50,790 female nurses participating in the ongoing nurses' health study ii. in addition to assessing the consequences of weight fluctuations, their correlates and course were identified.

background: in the united states, approximately one third of adult women are trying to lose weight. most weight losses are not sustained and in fact may be followed by gains of at least as much weight as was intentionally lost. it is unclear whether there are adverse outcomes associated with multiple intentional weight losses. design narrative: the prospective study addressed the impact of weight fluctuation on development of hypertension (hpt) and diabetes (dm) by following women who significantly fluctuated in weight compared to those who generally maintained a stable weight. the subject source was all participants between 1989 and 1993 in the nurses health study ii (nhs) who did not experience a full term pregnancy between 1989 and 1993 and who were free of hpt, dm and cancer in 1993. a random sample of each of two weight fluctuation classifications, \>20 lbs. (3 or more times) and 10-19 lbs. (3 or more times) was identified. a control group of non-fluctuators was matched by age and body mass index strata. baseline data consisted of information obtained from the 1993 nhs ii follow-up along with supplemental questionnaires sent to study participants to elicit specific information on past and present weight gain/loss and intentionality of weight fluctuation. prospective data came from follow-up questionnaires in 1995, 1997, and 1999. hypertension and dm ascertainment were obtained from self-report in the questionnaire. this ascertainment method appeared quite adequate based on validity studies carried out on subsamples of this cohort. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria