Kornimate/medical-research-clean huggingface dataset:
prion-1: quinacrine for human prion disease

Conditions: Prion Disease

Summary: prion-1 aims to assess the activity and safety of quinacrine (mepacrine hydrochloride) in human prion disease. it also aims to establish an appropriate framework for the clinical assessment of therapeutic options for human prion disease that can be refined or expanded in the future, as new agents become available.

the human prion diseases have been traditionally classified into creutzfeldt-jakob disease (cjd), gerstmann-sträussler-scheinker (gss) disease and kuru. they can alternatively be classified into three causal categories: sporadic, acquired and inherited. the appearance of a new human prion disease, variant cjd (vcjd), in the united kingdom from 1995 onwards, and the experimental evidence that this is caused by the same prion strain as that causing bovine spongiform encephalopathy (bse) in cattle, has raised the possibility that a major epidemic of vcjd will occur in the united kingdom and other countries as a result of dietary or other exposure to bse prions. these concerns have led to intensified efforts to develop therapeutic interventions. quinacrine has been previously used to treat other diseases such as malaria; however, it was found to have serious side effects and is no longer licensed in the united kingdom. there is only very limited evidence from laboratory tests for the potential use of quinacrine in human prion disease, and the evidence to date for any possible clinical benefit is very scarce. the prion-1 trial is being undertaken since there are no other drugs currently available which are considered suitable for human evaluation.

Eligibility criteria:
inclusion criteria: * aged 12 years or more, diagnosed with any type of human prion disease. exclusion criteria: * in a coma, or in a pre-terminal phase of disease such that prolongation of the current quality of life would not be supported * known sensitivity to quinacrine * been taking any other putative anti-prion therapy for less than 8 weeks

Keywords: creutzfeldt-jakob disease inherited sporadic acquired new variant cjd
exopulse mollii suit, motor function & stroke (exostroke)

Conditions: Spasticity As Sequela of Stroke

Summary: spasticity is a common and debilitating complication in neurological conditions such as multiple sclerosis, cerebral palsy, and stroke. stroke, a leading cause of global disability and death, occurs when blood flow to the brain is disrupted, causing neuronal damage. approximately 80% of strokes are ischemic, with 20% being hemorrhagic. several factors, including age, sex, vascular conditions, and lifestyle choices, increase the risk of stroke. spasticity affects 19-28% of stroke survivors in the short term and up to 46% in the long term, severely impacting mobility and quality of life. management typically involves pharmacological and nonpharmacological interventions, though these often have limited effectiveness and side effects. in this context, non-invasive techniques like transcutaneous stimulation with the exopulse mollii suit may offer a valuable alternative for managing spasticity and its associated symptoms.


Eligibility criteria:
inclusion criteria: * age between 18 and 75 years. * having a clinical diagnosis of stroke for at least three months * being able to walk freely or with the need of support (modified rankin score * 4) * being a french speaker, able to understand verbal instructions, and affiliated with the national health insurance (sécurité social). * having spasticity with a score of at least 1+ on the mas exclusion criteria: * being included in another research protocol during the study period. * inability to undergo medical monitor for the study purposes due to geographical or social reasons. * having contraindications for using exopulse mollii suit (having implanted electronic medical devices or equipment which can be disrupted by magnets or an electronic life support equipment or high-frequency operation equipment; e.g., cardiac stimulator, ventriculoperitoneal shunt, intrathecal baclofen pump). * being pregnant (confirmed by a blood beta-hcg test). * having a change in their pharmacological therapy in the last three months. * suffering from other somatic or neuropsychiatric diagnoses (e.g., arrhythmias, uncontrolled epilepsy, diseases causing osteoarticular and muscular pain). * having a body mass index above 35 kg/m2. * in case of introducing a medical device other than exopulse mollii suit during the study period. * patients under juridical protection (" mesure de protection) judiciare : tutelle, curatelle, sauvegarde de justice ") * patients deprived of freedom (" personnes privées de liberté ".)

Keywords: exopulse mollii suit motor functions &amp;amp; stroke spasticity
a comparison of pain scales in patients with disorder of consciousness following craniotomy

Conditions: Pain, Postoperative

Summary: this study aims to test validity, reliability and practicality of translated ncs, cnpi and flacc in unconscious patients in 48 hour following craniotomy.

this study aims to test predictive validity (sensitivity and specificity), content validity, concurrent validity, construct validity, inter-rater reliability and practicality of translated nociception coma scale (ncs) , checklist of non verbal pain indicator (cnpi) and the faces, legs, activity, cry, consolability observation tool (flacc) in unconscious patients in 48 hour following craniotomy.

Eligibility criteria:
inclusion criteria: 1. age \> 18 years old 2. preoperative intracranial lesion which predicts delayed recovery 3. disorder of consciousness within 48 hours after craniotomy assessed by using coma recovery scale-revised (crs-r) 17 4. not received postoperative sedation or muscle relaxants exclusion criteria: 1. documented history of prior brain injury 2. history of delayed development 3. prior psychiatric illness 4. prior neurological illness 5. superior limb contusion, fracture, paralysis -cannot move 6. thalamic hemorrhage -cannot express feeling

Keywords: pain scale craniotomy
the inspiratory muscle training in patients with non-specific chronic neck pain

Conditions: Neck Pain

Summary: the aim of the present study is to investigate the effects of additional functional inspiratory muscle training in individuals with non-specific chronic neck pain.

patients participating in the study will be divided two parallel groups. the patients in study group will instruct to perform both functional inspiratory muscle training and conventional treatments for neck pain, the patients in the control group will instruct to perform just conventional treatments. the severity of the pain, disability, fear of movement and depression levels will be assessed by visual analog scale, neck disability index, tampa scale of kinesiophobia and beck depression inventory, respectively. neck postures (craniovertebral angle) will be evaluated by photogrammetric method.endurance of deep cervical flexor muscles will be measured using stabilizer pressure biofeedback unit with cranio-cervical flexion test. pain threshold will be measured by algometer from the middle point of upper trapezius. cervical proprioceptions will be evaluated by laser pointer method in the right and left rotational directions. in addition, diaphragma thickness will be measured by two-dimensional ultrasonography. assessments were repeated before and after the treatment.

Eligibility criteria:
inclusion criteria: * ndi score above 15 * be able to adapt exercise commands * neck pain for at least six months * agree to participate in the study exclusion criteria: history of spinal surgery traumatic cervical injuries acute or chronic musculoskeletal pain other than neck pain serious comorbidities (neurological, neuromuscular, cardiological, psychiatric) tumoral conditions obesity (body mass index-bmi\> 40)

Keywords: inspiratory muscle training exercise cervical posture
stem cells for bronchopulmonary dysplasia

Conditions: Bronchopulmonary Dysplasia

Summary: very preterm infants are at high risk to develop to bronchopulmonary dysplasia (bpd) for the lack of effective measures to prevent or ameliorate this common and serious disorder. bpd remains a major cause of mortality and lifelong morbidity in preterm infants

several studies have shown that transplantation of mesenchymal stem cells (mscs) in immunocompetent animals attenuates lung injury, such as impaired alveolarization, inflammatory response, increased apoptosis, and fibrosis. human umbilical cord blood (hucb) is considered a better source of mscs because of their ready availability and greater proliferative capacity and less antigenicity than other cell types. transplantation of hucb-derived mscs should be effective in treating bpd. the safety and efficacy of msc transplantation for prevention of bpd has not been tested previously, however.

Eligibility criteria:
inclusion criteria: * diagnosed with bpd exclusion criteria: * parents' rejection
attention bias modification treatment for anxious youth

Conditions: Generalized Anxiety Disorder; Separation Anxiety Disorder; Social Phobia; Specific Phobia; Obsessive-Compulsive Disorder

Summary: the purpose of this project is to study the feasibility and efficacy of attention bias modification treatment (abmt) in a randomized-controlled sample of anxious youth.

the purpose of this study is to determine whether or not abmt computer-based interventions can be used successfully to help reduce anxiety disorder symptoms in children ages 7 to 17. abmt is different from most other treatments for anxiety because it is not medication or talk therapy. abmt is a computerized attention training program designed to change how we direct our attention. the purpose of abmt is to set in place attentional patterns that do not lead to excessive anxiety. research has shown that it may be highly effective in reducing anxiety. the intervention will be composed of your child engaging in 6 brief weekly abmt sessions. the sessions seem like a repetitive computer game. this study is appropriate for children who may have symptoms of an anxiety disorder, like generalized anxiety disorder, separation anxiety disorder, social anxiety disorder, specific phobia, or obsessive-compulsive disorder." children who appear eligible for the study may attend a diagnostic evaluation and assessment if they meet study criteria. if a child is eligible for the study, he or she will be randomly assigned to either get an "active" form of the computer program or a "placebo" or inactive form of the computer program. the child will come to six weekly appointments at our clinic that are quite brief, about a half hour. then the child will have an evaluation after the last of the six appointments to see if the computer intervention was helpful in reducing his or her anxiety. we'd then wait a month and then have a final evaluation to see if the child's anxiety has changed over that period of time.

Eligibility criteria:
inclusion criteria: * diagnosis on anxiety disorders interview schedule for diagnostic and statistical manual-iv child and parent versions of separation anxiety disorder, social phobia, specific phobia, obsessive-compulsive disorder, or generalized anxiety disorder * age 7 to 17 exclusion criteria: * posttraumatic stress disorder or primary diagnosis of major depressive disorder * seizure disorder * current treatment with psychotropic medication * multiple chronic learning disabilities and/or conduct problems
the neuroinflammatory response and biomarkers in acute traumatic spinal cord injury

Conditions: Spinal Cord Injury, Acute

Summary: the study is a prospective cohort study designed to assess the diagnostic and prognostic potential of biomarker measurement in acute traumatic spinal cord injury (tsci), and to examine the neuroinflammatory response to acute tsci.

tsci is an incurable condition with devastating consequences. the physical, psychosocial and financial implications in addition to a variable recovery and an uncertain prognosis have a profound impact on quality of life.the pathophysiology of tsci is dual consisting of a primary injury and a secondary injury. the immediate trauma to the spinal cord and nerve roots causes the primary injury, while a prolonged cascade of events causes the secondary injury. the neuroinflammatory response is considered to be an important event. current clinical measures to evaluate acute tsci consist of clinical examination and routine imaging modalities. these measurements are inaccurate to assess injury severity, prognosis, and therapeutic efficacy, especially in the early acute phase. biomarker measurement may provide a more accurate measure. this study aim to assess the diagnostic and prognostic potential of biomarker measurement in acute tsci, and to examine the neuroinflammatory response to acute tsci. to achieve this, immune cells, cytokines, autoantibodies and structural proteins will be analysed in blood and cerebrospinal fluid by flow cytometry and assay techniques. these analyses will be correlated to clinical outcome assessed according to international standards. hopefully, this will contribute with new knowledge of the neuroinflammatory response and biomarkers in acute tsci, and provide the needed knowledge for conducting futures trials in novel therapeutic interventions.

Eligibility criteria:
inclusion criteria: * traumatic spinal cord injury (bony level c1-l1) * isncsci score a-c upon inclusion. * age \>18-70 years. exclusion criteria: * prior major spine surgery in the traumatised location. * major co-morbidities or co-injuries. * penetrating spinal cord injury. * \>72 hours from injury to sample collection.

Keywords: spinal cord injury biomarkers inflammation trauma
map for coaches: translating sports injury prevention knowledge to youth sport coaches

Conditions: Knowledge, Attitudes, Practice

Summary: the goal of this clinical trial is to test the effectiveness of the map for coaches, a web-based musculoskeletal athletic injury prevention training course, in youth sport coaches. the main question it aims to answer are: * is the map for coaches effective in increasing coaches' sport-specific knowledge of musculoskeletal injuries (types, incidence, risk factors, mechanisms, and best prevention practices, with focus on neuromuscular training warm-up exercise programs)? * is the map for coaches effective in increasing coaches' motivation (self-efficacy and intention) to use sport-specific neuromuscular training warm-up exercise programs? the additional questions it aims to answer are: * are the effects of the map for coaches sustained in the short- and long-term? * is the map for coaches effective in promoting the use of sport-specific neuromuscular training warm-up exercise programs in youth sport coaches? regardless of group, participants will receive the map for coaches elearning training course; however, the participants allocated to the control group will have their post-test survey completed right after they review the sport-specific 2-page injury prevention e-book containing an overview of the map for coaches training course, including an infographic summary (summarized map for coaches elearning training course). the intervention group will complete the post-test survey after the full training including both the course summary and the detailed course modules (the full training). the investigators will compare the two groups to see if an exposure to the (full) map for coaches elearning training course improves study outcomes compared with the control group.


Eligibility criteria:
inclusion criteria: * active and ongoing engagement in team youth sport coaching * member of a youth sport organization in the united states * must be a team sport coach for one of the following: soccer, basketball, football or volleyball exclusion criteria: * additional engagement in adult coaching * no email address contact

Keywords: dissemination and implementation neuromuscular training exercise warm-up technology-enabled knowledge translation
state of coagulation in pre-eclampsia: comparing sonoclot signature analysis with conventional and specific haemostasis assays

Conditions: Pre-Eclampsia

Summary: * detection of the presence or absence of coagulopathy in cases with pre-eclampsia. * investigate the value of global hemostasis studies (sonoclot signature analysis) in cases of pre-eclampsia and if there a correlation between it and the specific traditional assays of hemostasis.

pre-eclampsia remains a major cause of morbidity and mortality in pregnant women, as well in their newborns (1). despite intense study, preeclampsia remains poorly understood and a major cause of maternal and foetal morbidity and mortality. it's clear that vascular endothelial dysfunction, which may lead to hypertension by imbalance between vasoactive, and vasodilator agents, is an important component of this disorder. the induction of endothelial dysfunction is probably multifactorial (2). some researchers suggested that hereditary and acquired thrombophilia has been associated with recurrent pregnancy loss and gestational vascular complications, such as early-onset pre-eclampsia and placental abruption (3). despite it is widely known that pregnancy induces a state of hypercoagulability (4), publications failed to demonstrate a uniform pattern of pathology that can carry the association between thrombophilia and adverse pregnancy outcomes, as between factor v leiden mutation, mthfr c677t mutation, g20210a prothrombin gene mutation, anti-thrombin iii deficiency, protein c,s deficiency and other causes of thrombophilia, different researchers claimed different causes of the previously mentioned as the one responsible for maternal thrombophilia (2, 3, 5). others claimed racial variations were associated with the state of thrombophilia (6). other than standard routine and specific tests, various other methods are used to record coagulation profile. one of them is estimation by sonoclot, which is a viscoelastic hemostatic assays device (7). sonoclot have practical advantages as point-of-care device for monitoring major hemorrhage including a set of parameters that assesses a global coagulation profile and can indicate the presence of hypercoagulable state (8). establishing correlations between sonoclot parameters and conventional hemostasis assays could open a path of better monitoring of patients with suspected coagulopathies, and can be helpful in guiding management of preeclampsia and preventing severe maternal outcomes (7).

Eligibility criteria:
inclusion criteria: 1. pregnant pre-eclamptic patients with blood pressure \> 140/90 mm hg and proteinuria \> 0.39/24 hrs., with gestational age between 20-42 weeks (second \& third trimester). 2. pregnant normotensive females with no pregnancy complications and gestational age 20-42 weeks to act as controls. exclusion criteria: 1. patients with gestational age \< 20 weeks (first trimester). 2. patients in labour. 3. patients with foetal malformations, history of chronic hypertension, diabetes mellitus, renal diseases, collagen vascular disease, anaemia, cardiovascular diseases and patients known to be thrombophilic before pregnancy (acquired or inherited).
traumatic below-knee amputees with prosthetics: health-related quality of life and locomotor capabilities

Conditions: Amputees

Summary: the present study assesses the health-related quality of life and the locomotor capabilities major traumatic lower limb amputees who use prosthesis.

a cross sectional study based on a retrospective review of prosthetic using major traumatic lower limb amputees' demographic and clinical details together with hrqol and locomotor capabilities patient-reported outcome measures.

Eligibility criteria:
inclusion criteria: 1. below-knee prosthesis users with amputation due to trauma 2. age \>18 exclusion criteria: 1. patients with no prosthesis
a multicentre study to evaluate the safety and efficacy of ad 923 in comparison to msir for the treatment of cbp in subjects

Conditions: Cancer; Pain

Summary: purpose: the purpose of this study is to compare the efficacy and safety of ad 923 to the most widely used current treatment (msir) in the management of target btp in subjects with malignancies who are taking a stable dose of background opioids. the efficacy evaluation criteria have been designed to determine whether ad 923 provides superior analgesia compared with msir as measured by the primary endpoint.


Eligibility criteria:
main inclusion criteria: * the subject is a male or female, at least 18 years of age. * the subject has a malignancy, is receiving opioid therapy for his or her underlying persistent cancer pain, and is tolerant to the opioid therapy. * the subject typically has 2 to 6 episodes of target btp per day that require treatment. * the subject has a life expectancy of \>3 months. * the subject or his or her caregiver has easy, reliable access to a telephone. main exclusion criteria: * the subject is a female who is pregnant or lactating. * the subject has any respiratory or cardiac condition that, in the opinion of the investigator, may be clinically worsened by opioids. * the subject has any allergy to the ad 923 product or excipients, namely: fentanyl, dehydrated alcohol, menthol, saccharin, and citrate buffer; or to the msir product excipients, namely: morphine sulphate, lactose (anhydrous), pregelatinized maize starch, povidone, purified water, magnesium stearate, talc, and tablet coatings. * the subject has any neurological or psychiatric disease that, in the opinion of the investigator, would compromise data collection. * the subject has uncontrolled or rapidly escalating pain. * the subject has any significant laboratory test results that, in the opinion of the investigator, will compromise subject safety or the conduct of the study. * the subject has plans to undergo chemotherapy, radiotherapy, or surgery during the treatment period. the exception is that subjects may continue chemotherapy over the study period, provided it is not expected to alter the pain state or response to pain medication.

Keywords: cancer breakthrough pain
development of machine learning models for the prediction of complications after colonic, colorectal and small intestine anastomosis in psychiatric and non-psychiatric patient collectives (p-study)

Conditions: Postoperative Complications; Psychosomatic Disorder; Psychiatric Disorder; Cancer; Diverticulitis; Morbus Crohn; Colitis Ulcerosa; Anastomotic Leak; Anastomotic Complication; Small Intestine Anastomotic Leak

Summary: our study aims to lay the basis for a predictive modeling service for postoperative complications and prolonged hospital stay in patients suffering from psychiatric diseases undergoing colorectal surgery. furthermore, we aim to investigate the impact of preoperative risk factors, psychiatric and psychosomatic diseases on the outcomes of colorectal surgery and the complications after colorectal surgeries like anastomosis insufficiency via predictive modeling techniques the service mentioned above will be publicly available as a web-based application


Eligibility criteria:
inclusion criteria: * colocolic, colorectal and small intestine anastomosis * neoplasia, * diverticulitis * mesenteric ischemia * iatrogenic or traumatic perforation * inflammatory bowel disease exclusion criteria: * patients \<18 years * patients suffering from recurrent colorectal cancer bearing * peritoneal carcinomatosis or unresectable metastatic disease at the time of bowel resection and anastomosis will be excluded. * patients who cannot be followed up on for more than six weeks after surgery

Keywords: machine learning clinical prediction modeling artificial intelligence