Kornimate/medical-research-clean huggingface dataset:
effects of increased physical activity before thoracoabdominal esophageal surgery

Conditions: Oesophageal Cancer

Summary: thoracoabdominal oesophageal resection for cancer is a procedure with high risks for complications, and patients' preoperative status is a crucial factor for outcome. there are only a few studies that evaluate the effect of preoperative intervention, including physical exercises and breathing exercises, after this type of surgery. the aim of the study is therefore to evaluate the effect of a training intervention before resection of the oesophagus. one hundred patients scheduled for oesophagus resection according to ivor-lewis from five different hospitals in sweden will be included. the patients will be randomized to an intervention group or a control group. the training intervention starts directly after preoperative radiotherapy and chemotherapy are given and lasts until three months postoperatively. intervention includes increased physical activity, strength training and respiratory muscle training. at inclusion and three months after discharge, the patients will undergo tests of physical function and lung function. in addition, they will fill in questionnaires concerning level of physical function, level of physical activity and quality of life. these questionnaires will also be answered one year after surgery.


Eligibility criteria:
inclusion criteria: * patients scheduled to undergo thoracoabdominal oesophagus resection at one of the five included centra exclusion criteria: * \< two weeks between inclusion and surgery * benign reason for surgery * difficulties in speaking and reading swedish * other injury or disease limiting the ability to perform the intervention.

Keywords: thoracoabdominal surgery physical therapy inspiratory muscle training physical activity
monitoring of breast cancers treated by neoadjuvant radiotherapy via magnetic resonance imaging

Conditions: Breast Cancer

Summary: magnetic resonance imaging (mri) is the method of choice in breast cancer to perform the loco-regional staging and direct the treatment. european guidelines (eusoma) currently recommend mri for initial evaluation and assessement of the neoadjuvant chemotherapy (nac) response, for breast cancer. the standard of care consists of realizing a mri before the start of the nac and another one after it's ended, six months later. there is currently no consensus on the realization of an interval mri for early assessment of the chemosensitivity of the tumor. it would allow though alterations in the therapeutic regimen in the event of a non response. similarly, there is no consensus on when this interval mri should be performed. some recent studies suggest that diffusion-weighted magnetic resonance imaging is interesting for the evaluation of the early response. however, these are preliminary studies with quantitative measures realized by the region of interest (roi) method. a response to neoadjuvant chemotherapy results in elevated values of apparent diffusion coefficients (adc). there is'nt any published data on the potential interest of breast mri after a radiotherapy treatment and before the surgical treatment. therefore, the expected benefits of this study are: * to monitor the early modifications of the perfusion and diffusion parameters at the level of the tumor after radiotherapy, and correlate them to the histology of the surgical monster. * to assess if mri is able to objectivate the early signs of response after a radiotherapy neo-adjuvant treatment of breast cancer. this record is linked to the nct02858934 record and will share the same cohort of patients


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * histological diagnosis of unifocal invasive breast carcinoma, no special type (ductal carcinoma) * tumor staging: ct1-2n0m0 * luminal a or b * candidate for breast conserving surgery * n0-status confirmed by lymph node cytology exclusion criteria: * multifocal/multicentric disease * prior thoracic radiotherapy * pregnancy * sbr3 grading * triple negative status which benefit neoadjuvant chemotherapy

Keywords: neo-adjuvant radiotherapy breast cancer mri
random-start ovarian stimulation in egg-donors (rose)

Conditions: Infertility

Summary: the purpose of this prospective single-center study is to evaluate the laboratory outcome after random start ovarian stimulation in oocyte donors. the study will be performed in egg-donors but this type of treatment has the potential to be implemented in general infertility population.

the study group will start ovarian stimulation randomly in different moments throughout the menstrual cycle. randomization will take place on day 2-3 of the menstrual cycle, according to a list of random allocation of treatments and egg-donors will be assigned to random start ovarian stimulation: during follicular phase starting at day 5,7,9,11 or 13 of the menstrual cycle and during luteal phase starting at luteinizing hormone (lh) peak +3,+5,+7,+9 or +11. egg-donors will receive urinary follicle stimulating hormone (fsh) 150-225 iu/d in gonadotropin-releasing hormone (gnrh) antagonist protocol with cetrorelix acetate 0,25 mg/d starting five days after ovarian stimulation and a gnrh agonist trigger with triptorelin 0,2 mg to induce the final follicular maturation. transvaginal ultrasound and serum analysis (estradiol, progesterone, lh and fsh) will be included for cycle monitoring.

Eligibility criteria:
inclusion criteria: * premenopausal women * 18-35 years old * fsh levels \< 10 iu/liter * antral follicle count (afc) \> 10 * regular cycles * body mass index (bmi) \< 28 * signed informed consent exclusion criteria: * polycystic ovary syndrome (pcos) patients * allergy to gonadotrophins * concomitant participation in other trial

Keywords: ovarian stimulation random egg donation antagonist gnrh agonist trigger
evaluating the efficacy of the mediterranean diet to the low- fermentable, oligosaccharides, disaccharides, monosaccharides, and polyols (fodmap) diet in treating irritable bowel syndrome(ibs)

Conditions: Irritable Bowel Syndrome

Summary: this study is being completed to determine if the mediterranean (md) and low fodmap (fermentable, oligosaccharides, disaccharides, monosaccharides, and polyols) diets are comparable in the effectiveness to treat irritable bowel syndrome (ibs). the study team hypothesizes that: * the low fodmap and mediterranean groups will achieve a similar improvement in abdominal pain * both groups will achieve similar improvements in bloating, overall ibs symptom severity, and adequate relief


Eligibility criteria:
inclusion criteria: * patients with ibs-d (diarrhea-predominant ibs) or ibs-m (ibs with mixed subtype) diagnosed per rome iv questionnaire and without any unexplained alarm features (rectal bleeding, weight loss, nocturnal symptoms, personal history of celiac disease, microscopic colitis, inflammatory bowel disease) * aged 18-70 years at the time of screening * weekly average of worst daily (in the past 24 hours) abdominal pain score of ≥3.0 on a 0-to-10-point scale * at least 80 percent compliance in daily questionnaire entries during the 7-day screening period exclusion criteria: * subjects adhering to any dietary ibs treatment such as the low-fodmap diet, or gluten-free diet, mediterranean currently or within the past 6 months * subjects with a known food allergy to eggs, seafood, peanuts, tree nuts or milk (subjects with lactose intolerance that are experiencing ibs symptoms while on a lactose-free diet will not be excluded from the study). * subjects with a history of poorly controlled insulin-dependent or non-insulin-dependent diabetes * subjects with a known history of organic gastrointestinal (gi) disease (i.e., celiac disease, inflammatory bowel disease or microscopic colitis) * subjects with a history of an eating disorder requiring medical or behavioral treatment within the past 10 years. * subjects with prior small bowel or colonic surgery (excluding appendectomy or cholecystectomy if over 6 months since these 2 procedures) * oral antibiotic use in the past 3 months * any planned significant changes in dietary or exercise regimen within 30 days prior to screening or during the study. * currently pregnant or breastfeeding.

Keywords: low fodmap diet mediterranean diet
stop hcc: mailed hcv treatment outreach program for hcc prevention for elevated lfts

Conditions: Hepatitis C; Hepatocellular Carcinoma

Summary: the investigators will conduct a randomized controlled trial comparing two strategies to promote hcv screening, follow-up testing, and treatment among parkland patients who are 18 years or older who have elevated liver functioning test (lft) results: in reach with electronic medical record alerts and provider education vs. combination of in reach and provider education plus mailed outreach and patient navigation.


Eligibility criteria:
inclusion criteria: * ages 18 or older * elevated liver functioning tests (ast or alt \>35 that are separated by at least one month) * ≥ 1 outpatient visit during 12 months prior to randomization at parkland * no prior hcv screening (prior hcv antibody, viral load, or genotype). * any active medical coverage * speaks spanish or english exclusion criteria: * a life expectancy less than one year including any history of metastatic cancer, and those who received a palliative care or hospice referral in the past year * history of hcc. * non-english or spanish speakers * no address or phone number on file
procalcitonin-guided antibiotic therapy in bronchiectasis

Conditions: Procalcitonin; Bronchiectasis; Antibiotic Therapy

Summary: to explore effectiveness of procalcitonin-guided antibiotic therapy in acute exacerbations of bronchiectasis, and to explore the clinical value of procalcitonin in bronchiectasis.


Eligibility criteria:
inclusion criteria: 1. bronchiectasis was diagnosed by high-resolution computed tomography based on the criteria published by mcshane pj et al. 2. acute exacerbations of bronchiectasis. 3. aged \>= 18 years. 4. procalcitonin been detected after admission. exclusion criteria: 1. associated with chronic obstructive pulmonary disease. 2. associated with asthma. 3. traction bronchiectasis caused by pulmonary fibrosis. 4. rule out other possible cause procalcitonin increased diseases such as cancer, connective tissue disease, active tuberculosis, chronic liver disease and respiratory system than the bacterial infection. 5. clinical data were incomplete. 6. can not follow up with the person.
treatment of periodontitis in menopausal patients

Conditions: Menopausal Patients; Chronic Periodontitis; Omega 3 Fatty Acids

Summary: the goal of this clinical trial is to compare the effectiveness of polyunsaturated fatty acids (pufas) \[omega-3\] as an adjunctive treatment to scaling and root planing for menopausal women with periodontitis versus scaling and root alone as a non- surgical treatment . . the main question it aims to answer is: • to investigate the effect of systemic administration of omega-3 fatty acids in addition to srp on clinical periodontal parameters and gcf levels of osteocalcin and ast in menopausal women. participants will given \* a soft gelatin capsules containing pufas to be consumed directly once daily for 12 months along with non-surgical treatment (group2) \*\* a soft gelatin capsules containing olive oil to be consumed directly once daily for 12 months along with non-surgical treatment (group1) researchers will compare group 1 to group 2 to see if pufas has an effect on clinical periodontal parameters and gcf levels of osteocalcin and ast in menopausal women. .

menopause is typically accompanied by significant systemic and oral manifestations, including hormonal changes and increased susceptibility to periodontal disease, which may involve inflammatory biomarkers like aspartate aminotransferase (ast) and osteocalcin in gingival crevicular fluid (gcf). the study aims to evaluate the effectiveness of regular inoculation of polyunsaturated fatty acids (pufas) as an adjunctive treatment for menopausal women's periodontitis. methods: twenty elderly women with chronic periodontitis were split evenly into two groups by random assignment. patients in group ii (the research group) were given soft gelatin capsules containing pufas to be consumed directly once daily for 12 months, as opposed to the group i (the control group), who received soft gelatin capsules containing some olive oil (placebo). scaling and root planning (srp) were used to address periodontal disease in all cases. at baseline, six and twelve months after treatment, clinical indicators and ast and osteocalcin amounts in the gcf will be noted.

Eligibility criteria:
inclusion criteria: * patients diagnosed as; periodontitis patients * presence of a minimum of 6 teeth in the mouth * at least 3 periodontal sites with probing pocket depth more or equal to 5mm * women experiencing menopause for at least a year exclusion criteria: * women suffering from any systemic disorder that might affect the periodontal tissues such as; diabetes mellitus, immune disorders,.. * anemic patients * smokers * patients taking nsaids, supplements, antibiotics regularly used mouthwashes within the last 3 months * participants in any other clinical trials

Keywords: periodontitis, gcf, osteocalcin.
results from a mexican acute promyelocytic leukemia.

Conditions: Promyelocytic Leukemia, Acute

Summary: retrospective, observational study, comparing treatments of acute promyelocytic leukemia in different centers in méxico. there is no sufficient information about acute promyelocytic leukemia in america latina, particularly in mexico. for these reason the investigators started a study adding all promyelocityc patients from the main hospital in mexico in order to put together a group of patient and analyze the response, overall survival and what are the characteristics of the population. the investigators included 5 hospital in mexico city and states as monterrey, guadalajara, san luis potosi, puebla, veracruz, yucatán, oaxaca, guanajuato, estado de méxico. even do, the investigators didn´t have arsenic trioxide they are treating patients with standard chemotherapy. these paper will help to show the authorities that the cost of treating patient with standard chemotherapy is much more higher than ato-atra. the investigators are now doing a cost benefit analysis so the investigators, can soon have ato treatment as standard of care in mexico for the treatment of acute promyelocytic leukemia.

a multicentric, retrospective, descriptive, longitudinal study was carried out. between january 2007 and january 2017, patients of both sexes and different ages, who were candidates for receiving intensive chemotherapy along with tretinoin were included in the study. the diagnosis for acute promyelocytic leukemia was determined based on the following criteria: abnormal promyelocytes in the bone marrow and verification of the t(15;17) translocation by karyotype or using rt-pcr to determine the genetic lesion and define the type of pml/rara isoform. in mexico the investigators still treating patients with anthracycline and cytarabine + transretinoic acid. these information will help the authorities to realize the importance of having arsenic trioxide as part of the treatment of these disease, knowing the amount of patient that the investigators have in mexico, knowing that in the hispanic race the incidence is greater.

Eligibility criteria:
inclusion criteria: * actute promyelocytic leukemia pml/rar alfa + diabetes mellitus hypertension asthma chronic renal disease exclusion criteria: * non acute promyelocytic leukemia younger than 15 years old
novel epidermal recording and detection of seizures

Conditions: Seizures; Encephalopathy; Asphyxiated Newborn

Summary: for any newborn that exhibits possible seizure activity or has altered mental status of unknown etiology, continuous bedside eeg recording is the standard of care to detect subclinical seizure activity. the experimental aspect of this study will be the application of test electrodes (ees or ekg) to evaluate if the electrodes can be used to produce a continuous bedside recording of brain activity in the same manner as an eeg recording, while ideally producing less irritation of newborn skin than conventional eeg electrodes.

infants admitted to our nicu that require a standard eeg for clinical diagnosis will be approached for consent to test one of two new methods of eeg recording. patients will be randomized to the new epidermal electronic system (ees) or the a hydrogel ekg electrode. all patients will continue to receive the standard of care eeg monitoring. ees is slim new temporary tattoo technology that can easily be applied to the skin without requiring a technician or scrubbing and preparation as with standard eeg lead. the hydrogel ekg are fda approved leads normally used to detect cardiac rhythm. specific aims: 1. to compare the rate of detection of neonatal seizures between a new method of recording electrical brain rhythms (ees or ekg) and the current standard of care (eeg, or electroencephalography.) 2. to compare characterization of electrical brain activity between ees or ekg and eeg in the neonate.

Eligibility criteria:
inclusion criteria: * hospitalized neonates who already require continuous eeg recording for clinical care * parents signed informed consent * cga 44 weeks or less exclusion criteria: * patient is moribund

Keywords: perinatal depression
effects of balance training in older adults with dementia

Conditions: Dementia

Summary: purpose -to investigate whether older adults with dementia who have balance and gait problems can improve their balance and gait function after an individualized 4-week tasks-oriented balance training with sensory manipulation. hypothesis -there is significant difference of timed up and go test, berg balance scale, walking speed, 30-s chair-stand test, chair sit-and-reach test and barthel index between dementia patients who received tasks-oriented balance training and those didn't receive after 4-weeks training and one month follow-up.


Eligibility criteria:
inclusion criteria: * patient provides oral consent, and written consent obtains from next of kin * older than 65 years * diagnosis of dementia, based on diagnostic and statistical manual of mental disorders, fourth edition (dsm-iv) or the international statistical classification of diseases and related health problems 10th revision (icd-10) * can follow order to complete the screening test(timed up and go test) * has balance and gait problems * can standing independently with/without assistive device or can standing with minimal assistance exclusion criteria: * newly developed cardiopulmonary disease and other exercise contraindications * other neuromuscular or musculoskeletal disease that might affect the outcome(ex. recent stroke, fracture or orthopedic surgery)
efficacy and safety of the combination of anlotinib and js001 in egfr-tki resistant t790m-negative nsclc

Conditions: NSCLC Stage IV; EGFR T790M-negative; Anlotinib; JS001

Summary: this study is designed to evaluate the efficacy and safety of the combination of anlotinb and js001 in egfr-tki resistant t790m-negative nsclc patients.

all egfr mutation nsclc patients with egfr-tkis eventually develop acquired resistance and in 40%-50% of these the resistance mechanism is based on the egfr t790m mutation who could receive osimertinib. several alternative mechanisms of escape from egfr-tkis have been detected in nsclc patients without the t790m, such as met application, braf mutation, pik3ca mutation, etc, who could receive the combination of egfr-tki with comparable target drug. given the lack of targeted therapy for the majority of t790m-negative patients, platinum-doublet chemotherapy remains the standard of care with low effectiveness. in the present study, we aimed to evaluate the efficacy and safety of the combination of anlotinb and js001 in egfr-tki resistant t790m-negative nsclc patients.

Eligibility criteria:
inclusion criteria: * adult patients \>=18 years of age * inoperable locally advanced, recurrent, and/or metastatic nsclc patients with egfr sensitive mutation * egfr-tki resistent * egfr t790m negative * expected survival ≥ 3 month; * ecog / ps score: 0-2; * the main organ function to meet the following criteria: hb ≥ 90g / l, anc ≥ 1.5 × 109 / l, plt ≥ 80 × 109 / l,bil \<1.5 times the upper limit of normal (uln); liver alt and ast \<2.5 × uln and if liver metastases, alt and ast \<5 × uln; serum cr ≤ 1 × uln, endogenous creatinine clearance ≥50ml/min exclusion criteria: * egfr-t790m positive * with druggable gene alteration; * patient can not comply with research program requirements or follow-up;
control and reward circuits in obsessive compulsive disorder

Conditions: Obsessive-Compulsive Disorder

Summary: the purpose of this study is to examine the brain functioning of ocd patients and healthy controls before and after treatment with exposure and response prevention (exrp) therapy.

the capacity to coordinate thoughts and actions to execute goal-directed behaviors (cognitive control) and the capacity to anticipate, respond to, and learn from reward (reward processing) are key processes for human behavior. dysfunction in these processes has been hypothesized to contribute to repetitive thoughts and behaviors in many disorders, including obsessive-compulsive disorder (ocd), tourette syndrome (ts), and eating disorders. we will use multimodal imaging to investigate neural circuits that support cognitive control and reward processing, using ocd as a model system. the short-term goal is to clarify how circuit-based abnormalities contribute to repetitive thoughts/behaviors; these data will inform future transdiagnostic studies. the long-term goal is to identify control and reward circuit-abnormalities as targets for new transdiagnostic treatments.

Eligibility criteria:
inclusion criteria for patients: * male and females with ocd aged 18-55 * diagnostic and statistical manual of mental disorders (dsm-5) diagnosis of ocd * not on psychotropic medication exclusion criteria for patients: * presence of metallic devices or dental braces in the body that are contraindicators for mr imaging * comorbid psychiatric conditions that significantly elevate the risk of study participation (e.g. psychotic disorders, bipolar disorder, evidence of dementia or other cognitive disorder, suicidality) * unstable medical conditions that need attention and would make participation in the study unsafe (e.g. very high blood pressure) * use of psychotropic medication * females who are pregnant or post-menopausal inclusion criteria for healthy volunteers - male and females aged 18-55 exclusion criteria for healthy volunteers * presence of metallic devices or dental braces in the body that are contraindicators for mr imaging * any psychiatric diagnosis * use of psychotropic medication * diagnosis of ocd in a first degree relative * females who are pregnant or post-menopausal * unstable medical conditions that need attention and would make participation in the study unsafe (e.g. very high blood pressure)

Keywords: ocd functional magnetic resonance imaging (fmri)