Kornimate/medical-research-clean huggingface dataset:
prevalence of sedentary lifestyle, pre-hypertension, and obesity

Conditions: Health, Subjective; Healthy

Summary: hypertension has been a serious problem among people from different ages in the last few decades, so by taking this in consideration we decided to search for specific risk factors that cause hypertension in young healthy adults, and to achieve that we are looking for pre-hypertension, obesity, and sedentary lifestyle among this group by using different scale tools and questionnaires.

hypertension has been a serious issue worldwide and there is a wide variety of content in literature regarding its risks, treatment modalities, and disease course. in this study, it was aimed to investigate the "pre-hypertension" state, which is the pre-step of hypertension, and to find its risk in young adults. while screening literature we found the incidence of pre-hypertension to be between 17% and 49% in individuals aged 18-30 years. however, study methods have generally been limited to blood pressure and anthropometric measurements. in our study, a holistic research will be carried out with different scales and questionnaires by enriching the method part. the aim of this study is to determine the incidence of prehypertension, sedentary life and obesity in healthy young adults aged 18-25, and then to determine the relationship between these risk factors. 382 young adults will be included in this study. blood pressure will be measured with a sphygmomanometer, subcutaneous fat tissue with a caliper, height with a height measurement device, waist and hip circumference with a tape measure, and body weight with a scale, bmi (body mass index) and double product will be recorded according to the data received by doing specific calculations. participant's physical activity status will be evaluated with the international physical activity scale and leisure activity scale, dietary habits with the dutch eating habits questionnaire, sleep status with the pittsburg sleep quality questionnaire, and psychosocial status with the perceived stress scale and beck depression scale.

Eligibility criteria:
inclusion criteria: * volunteer subjects exclusion criteria: * smoker subjects * alcohol drinker subjects * subjects who use drugs that affect blood pressure

Keywords: pre-hypertension sedentary lifestyle obesity risk factors
skin testing with recombinant bet v 1 and hypoallergenic recombinant bet v 1 fragments

Conditions: Atopic Dermatitis

Summary: aim of this study is to use the major allergen 1 of birch-tree pollen (bet v 1, betula verrucosa, synonymous betula pendula), to investigate the contribution of immunoglobulin e (ige)- versus non-ige-mediated mechanisms to chronic skin inflammation in atopic dermatitis patients.

in this study non-ige-reactive recombinant bet v 1 (rbet v 1) fragments (f1: aa 1-74; f2: aa 75-160) and the fully ige-reactive recombinant bet v 1 (aa 1-160)will be used for skin prick testing and atopy patch testing in birch pollen allergic patients with birch pollen induced exacerbation of atopic dermatitis. for control purposes birch pollen allergic patients without birch pollen-induced atopic eczema, persons with allergies other than to birch and non-allergic people will be tested. the individuals will be subjected to in vivo skin prick and atopy patch testing with rbet v 1, rbet v 1 fragment 1, rbet v 1 fragment 2 and an equimolar mix of the rbet v 1 fragments. in parallel, the ige reactivity, and in vitro t cell proliferation, and cytokine production will be studied. those analyses should help to determine the relevance of ige mediated mechanisms to chronic skin inflammation and t cell proliferation in ad patients. a staining for the surface markers chemokine receptor (ccr4)+ and cutaneous lymphocyte antigen (cla)+ which reportedly are enriched in inflamed skin will further allow to investigate whether patients with high numbers of t lymphocytes expressing ccr4 and cla tend to exhibit stronger skin inflammation. moreover, allergen-specific antibody and t cell responses will be analyzed 6-8 weeks after the epicutaneous allergen application.

Eligibility criteria:
inclusion criteria: 1. age between 18 and 75 years 2. they will be available to complete the study exclusion criteria: 1. severe general maladies 2. severe skin inflammation in the test area 3. risk of non-controllable general reaction 4. pregnancy and breast-feeding 5. autoimmune diseases, immune-defects including immuno-suppression, immune-complex-induced immunopathies 6. contra-indication for adrenaline 7. patients under long-term treatment with systemic corticosteroids immunosuppressive drugs, tranquilizers or psychoactive drugs 8. positive ige reaction on hypoallergenic bet v 1 derivatives 9. the subject is currently participating in another clinical study in which the subject is or will be exposed to an investigational or a non-investigational drug. 10. the subject is at risk of non-compliance with the study procedures/restrictions

Keywords: atopic dermatitis bet v 1 bet v 1 fragments allergy
rapid detection method for microorganisms in the lower genital tract

Conditions: Infertility, Female

Summary: mycoplasma, chlamydia, and gonococcal infection of the female lower genital tract can lead to infertility and various adverse pregnancy outcomes. the lower genital tract bacterial community status type (cst) is closely related to genital tract infection and reproductive health. however, there is a need for a rapid, accurate, stable, and economical detection method to detect the above pathogens and cst at the same time, so there is also a need for evaluation of the correlation between each pathogen infection and cst. matrix assisted laser desorption ionization time-of-flight mass spectrometry (maldi-tof ms) is more stable and accurate than traditional detection methods such as culture and staining. it can simultaneously detect a variety of microorganisms and their subtypes, while the high-throughput sequencing method is faster and more economical, which is suitable for detecting multiple microorganisms in clinical practice. the research group has established a perfect maldi-tof ms platform in the early stage and put it into clinical testing. this project will establish a new rapid detection method for lower genital tract microorganisms based on maldi-tof ms. then, examine the lower genital tract microecology of infertile patients and healthy women using the newly developed method. at last, analyze the correlation between pathogen infection, cst status, and infertility. this project will solve the practical work needs of clinicians for a comprehensive assessment of female lower genital tract cst and common pathogen infection and fill in the technical gaps in the microbial examination of the lower genital tract.


Eligibility criteria:
inclusion criteria: case group: 1) female aged 18-40 2) regular menstrual cycle 2) conform to the clinical diagnosis of infertility 3) no sexual life 3 days before the examination control group: 1. female aged 18-40 2. regular menstrual cycle 3. patients who did pre-pregnancy consultation in our hospital, pregnant at the time of 3-month follow-up 4. no sexual life 3 days before the examination - exclusion criteria: case group: 1. infertility due to malformation of reproductive tract 2. infertility caused by endocrine factors such as polycystic ovary syndrome, premature ovarian failure and severe hyperthyroidism 3. infertility due to male factors 4. patients with malignant tumors 5. patients with autoimmune diseases 6. patients with severe heart, kidney and other basic diseases 7. patients who consumed antibiotics 3 days before the examination 8. have the habit of smoking and drinking control group: 1. pregnancy by various assisted reproductive means 2. patients with malignant tumors 3. patients with autoimmune diseases 4. patients with severe heart, kidney and other basic diseases 5. patients who consumed antibiotics 3 days before the examination 6. have the habit of smoking and drinking
hemostasis using surgicel in pediatric tonsillectomy

Conditions: Tonsil; Injury; Surgical Blood Loss

Summary: tonsillectomy is one of the commonest procedures performed in otolaryngology and one of its major complications is post-tonsillectomy bleeding. the goal of this study was to assess the effectiveness of surgicel without bipolar cautery in achieving primary hemostasis in tonsillectomy. the patient that were enrolled in this retrospective study were patients who underwent tonsillectomy and achieved hemostasis either by surgicel (group a) or bipolar cautery (group b). our results showed that there was no statistical significant difference between the two techniques in terms of post-operative bleeding events.

tonsillectomy is one of the commonest procedures performed in otolaryngology and one of its major complications is post-tonsillectomy bleeding. the goal of this study was to assess the effectiveness of surgicel without bipolar cautery in achieving primary hemostasis in tonsillectomy. the study was a retrospective cohort in three tertiary care centers in xxxx, from january 2016 to august 2018. all patients underwent at least tonsillectomy, with a proportion undergoing additional adenoidectomy, myringotomy, or tube insertion as indicated, were enrolled in the study. patients were stratified to 2 groups according to the surgeons preference for the hemostasis technique, one was subjected to cold dissection tonsillectomy and achieved hemostasis via the application of surgicel to the surgical site, and the other underwent cold dissection tonsillectomy and attained hemostasis through bipolar cautery.

Eligibility criteria:
inclusion criteria: * patients under age of 12, diagnosed with recurrent tonsillitis or osa and are candidates for tonsillectomy * patients must have went tonsillectomy exclusion criteria: * age more than 12

Keywords: tonsillectomy primary hemostasis tonsillectomy surgicel
sleep disorders in patients with suspected lung cancer before and after thoracic surgery

Conditions: Lung Cancer

Summary: the main aim of this study is to prospectively evaluate the occurrence of sleep disorders in patients undergoing thoracic surgery due to the preliminary diagnosis of lung cancer. secondary aims include anxiety, depressive mood and functional outcomes before and 3 months after the intervention.

cancer surgery is one of the traumas that affect human life, starting from diagnostic procedures, along with the recovery process. although 5-year survival in lung cancer has increased to 60%, there is a general prejudice that lung cancer has a poor prognosis. a preliminary diagnosis of a such condition has consequently a negative effect on the mood and sleep patterns of the patients, starting already from the beginning of the diagnostic procedures. in our study, we want to evaluate the occurrence of sleep disorders, anxiety, depressive mood and functional outcomes before and 3 months after the surgical intervention. this would also help us to better identify the patients in need for professional support for sleep disorders as well as psychiatric conditions, and thus, a better management of patients with lung cancer.

Eligibility criteria:
inclusion criteria: * patients who will undergo lung resection with a pre-diagnosis of lung cancer * being literate or having the physical strength to answer questions. exclusion criteria: * the patient has a chronic disease such as dementia or treatment-resistant schizophrenia in which reality assessment is impaired. * patients who have received chemotherapy and / or radiotherapy due to their previous disease.

Keywords: sleep disorder vats lung cancer robotics thoracoscopy
autologous hematopoietic stem cell transplantation for early onset type 1 diabetes

Conditions: Type 1 Diabetes Mellitus

Summary: this is a phase ii trial in individuals who have been diagnosed with type 1 diabetes within the previous 6 months. the study is evaluating whether stem cell transplantation is safe when chemotherapy and immunotherapy are used in combination and if it has immune resetting effect that may halt the immune attack to pancreas islets and thus preserve the body's own insulin production.

type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks the insulin-producing beta cells in the pancreas. generally, at the time someone is diagnosed with type 1 diabetes, not all of a person's beta cells have been destroyed. it's important to preserving the remaining precious beta cells so as to stop the diabetes progression. the exact mechanism of action of autologous hematopoietic stem cell transplantation(ahst) in autoimmune disorders is not fully understood. preliminary data supported post-ahst immune resetting included an increase in thymus-derived naive t cells, decreased central-memory t cells, increased output of recent thymic emigrants, and recovery of a diverse but distinct t-cell receptor repertoire following ahst. in the patients of type 1 diabetes, decreasing titer of anti-gad antibody may bring improvement of beta-cell function after intensive immunosuppression. furthermore, there may exit the possibility of regeneration of beta cells from surviving beta cells or from pancreatic or bone marrow stem cells. patients recently diagnosed (less than 6 months) with type 1 diabetes mellitus proved by positive antibody against glutamic acid decarboxylase will be included in this study. hematopoietic stem cells will be mobilized with cyclophosphamide (2.0 g/m2) and granulocyte colonystimulating factor (10 μg/kg per day) and then collected from peripheral blood by leukapheresis and cryopreserved. the cells were injected intravenously after conditioning with cyclophosphamide (200 mg/kg) and rabbit antithymocyte globulin (4.5 mg/kg). this procedure is performed in isolated rooms at the bone marrow transplantation unit of shanghai ruijin hospital affiliated to shanghai jiao-tong university school of medicine. patients will be discharged from the hospital 1 month after transplantation and continue the follow-ups for 3 years. patients fitting the inclusion criteria but not agreeing to perform the transplantation are the control group and they will be followed in parallel with transplanted patients.

Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus diagnosed by clinical/metabolic parameters and positive anti-gad antibody * less than 6 months from diagnosis exclusion criteria: * previous diabetic ketoacidosis * pregnancy * severe psychiatric disorder * severe organic impairment (renal, hepatic, cardiac, pulmonary) * active infectious disease * previous or present neoplastic disease

Keywords: diabetes mellitus stem cells autologous stem cell transplantation autoimmune diseases
effects of a multimodal preference-based parental intervention on preschoolers' physical activity behaviour - a cluster-randomized trial

Conditions: Obesity

Summary: this study investigates whether a preschool-based physical activity intervention involving parents as active agents of behavioral change affects objectively measured physical activity in preschool children.

in the last 25 years, obesity in children has increased dramatically in germany (lampert et al. 2007, stolzenberg et al., 2007) and other western societies. lack of physical activity (pa) is one important factor contributing to obesity development. however, healthy behaviors are established early in life (adiposity rebound: reilly 2008), which underlines the importance of early interventions. preschools therefore might be an ideal setting for interventions to promote physical activity. while previous preschool interventions were directly aimed at the children's physical activity behaviors (e.g. promoting activity by sports lessons), parents as influential caregivers were mainly involved in educational ways and by information (e.g. newsletters, physical activity homework). the current intervention takes a participatory approach to involve parents as active agents of behavioral change. the study aim is to evaluate the effects of the participatory preference-based parental intervention on preschoolers' objectively measured physical activity behaviour and body mass index (bmi). the intervention can easily be added as a parent module to existing children-focused physical activity programmes. in several workshops, parents are presented a set of possible project ideas for improving everyday physical activity in the preschools. after forming teams, they either select project ideas from the preexisting menu or develop ideas de novo and then implement them into the local preschool environment. the intervention is implemented in the frame of an existing state-sponsored physical activity (pa) program offering twice weekly sports lessons by external gym trainers to preschoolers over a period of 6 months. preschools in the control arm get the state-sponsored pa program only. preschools in the intervention arm get the participatory parent-focused pa intervention in addition to the existing state-sponsored pa program.

Eligibility criteria:
inclusion criteria: * healthy children * participation in the standard physical activity lesson twice weekly exclusion criteria: * age under 3 years or above 6 years * serious atopic dermatitis * genetic conditions * metabolic diseases * acute infectious diseases
nutrients and hormones: effects in boys with disordered growth

Conditions: Constitutional Growth Delay; Nutrition Disorders; Growth Disorders

Summary: the purpose of the study is to find out if patients with constitutional delay of growth have a mismatch between energy intake and utilization (as measured by doubly labeled water) and to compare the improvement in growth and energy balance between a group of boys treated with growth hormone (gh) alone versus those given gh plus added nutritional supplements for one year.

two groups of boys 7-10 years old who are very short and below average in weight but otherwise healthy will be studied. one group will be observed initially for 6 months and then receive gh injections every day for the subsequent 12 months. another group of boys will get a high-calorie drink every day for 6 months, and then receive gh injections plus the supplement every day for the next 12 months. we will compare how well boys grow in height, weight and the changes in body composition. we will compare diet and energy usage using the doubly labeled water technique. a battery of hormonal and nutritional tests will be performed, as well as body composition assessment.

Eligibility criteria:
inclusion criteria: * boys 7-10 years old who are very short and below average in weight but otherwise healthy. * delay in skeletal maturation \> 1 year. exclusion criteria: * growth hormone deficiency * chronic illness * participation in high endurance athletics

Keywords: gh delayed growth energy expenditure puberty nutrition short stature
serum brain natriuretic peptide levels and pulmonary hypertension in pediatric sickle cell patients

Conditions: Pulmonary Hypertension

Summary: the purpose of this study is 1. to determine if brain natriuretic peptide levels correlates with elevated tricuspid regurgitation flow velocity levels in pediatric patients with sickle cell disease 2. to determine the role of age, gender, steady state hemoglobin and disease type on brain natriuretic peptide levels and pulmonary hypertension

pulmonary hypertension is recognized as a significant cause of morbidity and mortality in patients with sickle cell disease. doppler echocardiography is a recommended noninvasive screening tool for sickle cell disease patients with pulmonary hypertension. brain natriuretic peptide levels have been found to be a possible serum screening marker. this research will offer the opportunity to determine if there is any possible relationship between magnitude of bnp concentration and degree of trv, if it can be used as a screening test in scd pediatric patients with pht and form the basis for a future multicenter study

Eligibility criteria:
inclusion criteria: * male and female any age * diagnosis of scd with pht on echocardiogram * controls must have a diagnosis of sickle cell disease without pulmonary hypertension, age, gender and disease type match to subjects with pulmonary hypertension * parent or legal guardian willing to sign informed consent form exclusion criteria: * abnormal echocardiograms not related to pht * parent or legal guardian unwilling or unable to give written informed consent

Keywords: pulmonary hypertension sickle cell disease pediatric patients brain natriuretic peptide levels
expanded development of a medical device utilizing an eeg-based algorithm for the objective quantification of pain

Conditions: Chronic Pain

Summary: painqx is conducting a study to collect electroencephalography (eeg) data from 250 people with chronic pain and 50 healthy controls in order to develop algorithms that will objectively assess the level of pain a person is experiencing.


Eligibility criteria:
inclusion criteria: * male and female chronic pain patients * patients between the ages of 18-85 years * patients exhibiting the presence of symptoms in excess of 3 months duration * patients suffering from neuropathic (e.g., lower back pain), osteoarthritis, or muscular skeletal pain * patients with evidence of pathology related to the painful condition on which diagnosis was made (e.g., results of imaging or diagnostic pain code) patients with nrs pain scores across the full range (1-10) at the time of testing inclusion criteria, normal (no-pain) group o subjects will be included with no history of pain with a duration of greater than 3 months, and no report of pain at the time of testing (or within 3 months of testing) exclusion criteria: * patients with medically diagnosed psychotic illness * patients with medically diagnosed drug or alcohol dependence in the past 12 months * patients with a medical history of head injury with loss of consciousness and amnesia (within the last 2 years) * patients with skull abnormalities that preclude the proper placement of the electrodes for the eeg data acquisition * patients who have a spinal cord stimulator, or other implantable devices * patients for whom the source of pain at the time of the evaluation is associated with: neurological disorders (multiple sclerosis, parkinson, dementia), diabetes, migraines, or those with reflex / sympathetic dystrophy disorder/complex regional pain syndrome, fibromyalgia, or visceral pain note: this does not exclude patients who suffer from these disorders if the current source of pain is not due to the disorder. for example, patients with diabetes are not excluded, but patients whose pain at the time of the evaluation is a result of diabetic neuropathy are excluded. similarly, patients with a history of migraines but for whom a migraine is not the current source of pain at the time of the evaluation are not excluded. * patients with cancer * patients on workers compensation or disability * patient on anticonvulsant medication * patients who have a history of seizures