Kornimate/medical-research-clean huggingface dataset:
ise to support constipation management

Conditions: Constipation

Summary: this study is a single site prospective controlled trial assessing two educational interventions designed to educate local pediatric primary care physicians (pcp) and nurses on collaboratively developed treatment guidelines for pediatric constipation. the study aims to assess the impact of an spaced education game to aid the implementation of the management guideline. pcp adherence to recommended treatment will be assessed in addition to pcp satisfaction with the educational methods, constipation knowledge and patient outcomes.

primary care practices in the greater cincinnati region, that are part of the ohio valley pediatric care association (ovpca) will be recruited to take part in the study. it is estimated that approximately 170 providers in 40 practices will take part overall. the study participants will be the pcps and nurses in their practices. prior to the educational intervention (described below), participating pcps and nurses will be asked to complete constipation action plan (cap) forms detailing the treatments they prescribed to each patient with constipation symptoms at each new visit and the subsequent follow up visits for constipation. the cap form will contain a section to describe the patient's symptoms as well as fields to be checked for each treatment the pcp instructed the patient to follow. practices will be clustered by size (number of providers) and randomly assigned to 1 of 2 educational interventions (dissemination or dissemination +interactive spaced education). dissemination will include webinars and e-mail distribution of the constipation management guideline and a slide set containing the evidence-based rationale as well as clinical tips for advanced management of functional constipation. all pcps will receive the guideline and slide set and be offered an opportunity to ask questions of a gastroenterologist. participating pcps and nurses randomized to the interactive spaced education (ise) arm will complete an online ise course assessing their understanding of the constipation guidelines. constipation knowledge will be tested via quiz in multiple choice format. online surveys to assess satisfaction with the educational intervention, likelihood to change practice, ease of participation in the se course (if applicable) and feedback for ways to improve future educational efforts will be administered at three time-points.

Eligibility criteria:
inclusion criteria: * pcps and nurses who are willing and able to complete the education intervention throughout the study time-frame, as outlined in the protocol (education intervention does not need to be completed prior to taking part in the study) * pcps and nurses who are willing to complete constipation action plans and submit them in a timely fashion to the cchmc quality improvement program staff exclusion criteria: * pcps or nurses who are unwilling and/or unable to follow protocol requirements.
nolpitantium besylate in patients with ulcerative colitis a double-blind, placebo controlled efficacy and safety study

Conditions: Ulcerative Colitis; Inflammatory Bowel Disease

Summary: to evaluate the safety and efficacy on clinical symptoms, mucosal histology and endoscopic mucosal appearance of two doses of sr140333b against placebo in patients with mild to moderate ulcerative colitis resistant to treatment with 5-asa.

patients with active mild to moderate ulcerative colitis that has not responded to a minimum of 4 weeks of 5-asa will be randomized to receive single daily doses of either placebo, 600 mg sr140333b or 1800 mg of sr140333b for eight weeks. patients will undergo baseline and end of study sigmoidoscopic assessments and complete daily symptom diaries during the study. ulcerative colitis disease activity will be measured by both the overall and component subscores of the mayo disease activity index.

Eligibility criteria:
inclusion criteria: * age at least 18 years * ulcerative colitis of at least 6 months duration * patient's ulcerative colitis should remain active while taking 5-asa or sulfasalazine for at least 4 week * if taking corticosteroids, dose must be stable for at least 2 weeks prior to enrollment and not exceed 20 mg per day (prednisolone equivalent) exclusion criteria: * crohn's disease * colonic dysplasia * stool culture positive for enteric pathogens * concurrent cancer or unstable medical condition * recent treatment with monoclonal antibody * recent introduction of thiazolidinedione * recent treatment with methotrexate or cyclosporine * recent treatment with an antibiotic prescribed for ulcerative colitis

Keywords: nk1 antagonist inflammatory bowel disease mesalamine
metabolome analysis in patients with rheumatoid arthritis

Conditions: RheumatoId Arthritis

Summary: the aim of this study is to investigate discriminant metabolites in urine from patients with rheumatoid arthritis (ra) from healthy individuals. then we determine if the patient's metabolic fingerprint could predict the development or flare-up of ra.

compare metabolites between ra patients and healthy individuals. 1. collection urine sample 2. assessing urine metabolites by 1h nmr spectroscopy 3. analyzing the relationships between metabolites and clinical variables

Eligibility criteria:
inclusion criteria: * all patients with rheumatoid arthritis meet 2010 american college of rheumatology/european league against rheumatism classification criteria. exclusion criteria: * comorbid with other autoimmune diseases * confirmed with amyloidosis * chronic kidney disease (estimated gfr \< 60 ml/min/1.73m2) * chronic liver disease * thyroid disease * pregnancy * solid tumor/hematologic malignancy within 5 years

Keywords: rheumatoid arthritis metabolomics urine
abriendo caminos 2: clearing the path to hispanic health

Conditions: Obesity; Childhood Obesity; Nutrient; Excess; Community Health Education

Summary: obesity is significantly higher in specific ethnic groups and, in particular, hispanics. there is an urgent need to implement culturally-sensitive lifestyle interventions and educational programs to decrease the burden of obesity and obesity-related metabolic diseases in hispanic populations. accordingly, our overreaching goal is to tailor an existing and successful community-based program, abriendo caminos, to leverage effectiveness in promoting healthy nutrition and life-style behaviors among low income, low literacy hispanic-heritage families. our multi-function integrated project proposes to (a) adapt abriendo caminos for 6-18 year-old children from mexican and puerto rican heritage in five different locations (california, illinois, iowa, puerto rico, and texas) and (b) train existing professionals (in extension and community agencies) and future professionals (hispanic university students) to meet the specific needs of this population. our central hypothesis is that participation in a 6-week community-based program will prevent childhood obesity/maintain healthy weight by significantly increasing: (a) healthy dietary behavior patterns and basic knowledge of nutrition; (b) physical activity levels; and (c) the organization of collective/shared family mealtimes. the implementation of this culturally sensitive, workshop-based curriculum in different regions across the country will help to train the next generation of professionals in extension and communities to deliver programs that meet the needs of hispanic families. the integration of hispanic college students in program implementation via an experiential learning course will further strengthen the program, as well as increase recruitment and retention of hispanic students, increasing the capacity of hispanic communities to meet their own needs in the future.


Eligibility criteria:
inclusion criteria: * a family member being 6-18 years of age * at least 1 parent being of hispanic-heritage from mexican or puerto rican origin exclusion criteria: * no child in the age range of 6-18 years of age * no parents being of hispanic-heritage from mexican or puerto rican origin
the effects of breathing exercises and postural exercises in young adults with asthma.

Conditions: Asthma

Summary: the aim of this study was to investigate the effects of breathing exercises and postural exercises via telerehabilitation on respiratory parameters, posture, and quality of life in young adults with asthma.

12 young adult (18-25 years old) individuals diagnosed with asthma participated in our study (all female). all of the participants are university students. participants included in the study were evaluated with asthma control test, mini asthma quality of life questionnaire, international physical activity questionnaire (short form) via google forms; sit to stand test, respiratory rate per minute and oxygen saturation were assessed at yeditepe university physiotherapy and rehabilitation laboratory both at baseline and at the end of the 5th week. breathing and postural exercises were given to the participants for the duration of 5 weeks.

Eligibility criteria:
inclusion criteria: * voluntary participation in research. * patients in young adults (18-26 years old) * stable asthma. * modified medical counsel research dyspnea test (mmrc) is 2 and above * to stay consistent with an exercise program. exclusion criteria: * being younger than 18 years old. * patients with severe asthma. * modified medical counsel research dyspnea test (mmrc) is below 2

Keywords: asthma young adults breathing exercises postural exercises quality of life posture asthma control telerehabilitation oxygen saturation respiratory rate per minute
the effect of ocular massage on the management of elevated intraocular pressure after acute angle closure

Conditions: Intraocular Pressure

Summary: lowering intraocular pressure remains the mainstay of therapy in the management of glaucoma. the effect of ocular massage on intraocular pressure in patients with acute primary angle closure was the important thing.this was a prospective study, in which 20 eyes from 20 patients had acute angle closure. when they went to the hospital, ocular massage was performed without any medication. intraocular pressure was detected by goldmann tonometer, and lenstar ls900 optical biometry observed changes of anterior chamber depth before and after ocular massage. anterior chamber depth, anterior chamber angle and ciliary body were observed by ultrasound biomicroscopy after massage, and anterior chamber angle was also checked by gonioscope after massage.

background: primary angle closure glaucoma is still the most common type in asia. lowering intraocular pressure remains the mainstay of therapy in the management of glaucoma, since it has been shown to be effective in reducing optic nerve damage and loss of vision. the objective of this study was to evaluate to assess the effect of ocular massage on intraocular pressure in patients with acute primary angle closure. methods : this was a prospective study, in which 20 eyes from 20 patients had acute angle closure. when they went to the hospital, ocular massage was performed without any medication. intraocular pressure was detected by goldmann tonometer, and lenstar ls900 optical biometry (lenstar ls900) observed changes of anterior chamber depth before and after ocular massage. anterior chamber depth, anterior chamber angle and ciliary body were observed by ultrasound biomicroscopy (after massage, and anterior chamber angle was also checked by gonioscope after massage.

Eligibility criteria:
inclusion criteria: * all of them had documented evidence of acute angle closure. exclusion criteria: -

Keywords: acute angle closure ocular massage
acute effect of resistance training in inflammatory markers in women with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: abstract introduction: rheumatoid arthritis (ra) is a systemic inflammatory, chronic and progressive disease that can lead to joint destruction and important functional disability. chronic inflammation, with a substantial increase in the amount of pro-inflammatory cytokines in synovial joint, is one of the biggest challenges in controlling ra. resistance exercise has been recognized for positively modulate inflammation in healthy subjects. objective: to evaluate the effect of an acute bout of resistance exercise on serum concentrations of tumor necrosis factor alpha (tnf-α), interleukin 1 receptor antagonist(il-1ra), interleukin 1 beta (il-1β), c reactive protein (crp), interleukin 6 (il-6), interleukin 10 (il-10), and cartilage oligomeric matrix protein (comp) in postmenopausal women with ra and women without the disease. methods: 17 volunteers with ra and 17 without the disease, with a mean age of 54.7 + 6.63 underwent a resistance exercise session with a set of 12 repetitions at 50% of one repetition maximum (1rm ) and a set of 8 repetitions at 75% of 1rm. the exercises performed were: knee extension, knee flexion, hip abduction and hip adduction. blood samples were obtained 30 minutes before, 5 minutes before, immediately after, 1 hour, 2 hours and 24 hours after the exercise session. serum glucose concentrations prior to exercise were also measured. the investigators used the student's't test, the model of analysis of variance with repeated measures and bonferroni method of multiple comparisons to analyze the data, being considered statistically significant levels of p \<0.05.


Eligibility criteria:
\*rheumatoid arthritis group inclusion criteria: * women classified acording to the american college of rheumatology's criteria to rheumatoid arthritis * post menopausal women * stable medication three months before study exclusion criteria: * women with rheumatoid arthritis with functional class iv, acording to acr criteria * women engaged in some type of regular exercise program; * failure: heart, coronary, respiratory, renal and / or hepatic (uncompensated); * uncompensated systemic hypertension; * volunteers with other associated inflammatory diseases; * unable to perform the exercises. * control group we included in the control group of this study postmenopausal volunteers, without rheumatoid arthritis. exclusion criteria were the same as those adopted for the participants of the rheumatoid arthritis group
diagnostic breath analysis for detection of ventilator acquired pneumonia (vap)

Conditions: Bacterial Infections

Summary: breath samples from patients with ventilator acquired pneumonia (vap) will be analyzed to identify volatile organic compounds (voc) that have been specifically associated with vap in previous animal models. primary outcome measures will include the assessment of the znose diagnostic breath analysis system in the early detection of voc's associated with vap.

on clinical suspicion of vap, breath samples will be collected from the expiratory limb of the patient's ventilator tubing circuit. a sterile tedlar collection bag will be used to connect to the sample port and collect the breath sample. the expiratory limb sample port will be utilized to ensure maintenance of the integrity of the ventilator circuitry. the breath samples will be analyzed via the znose breath analysis system. immediately following collection of breath samples, bronchoalveolar lavage fluid (balf) will be collected and subjected to bacteriology testing for confirmation of vap-positive and vap-negative patients.

Eligibility criteria:
inclusion criteria: * patients ≥ 48 hours of ventilation with suspected vap infection. suspicion of vap infection based on clinical evaluation criteria: 1. three or more positive out of the following: 1. tympanic temperature \> 38 °c or \< 35.5 °c 2. blood leukocytosis (10,000/µl) 3. more than ten leukocytes in gram stain of tracheal aspirate (in high-flow field) 4. positive culture of tracheal aspirate 2. new, persistent, or progressive infiltrate on chest radiograph exclusion criteria: patients with pre-existing structural lung disease (copd, asthma, lung cancer, etc.), thrombocytopenia (\< 40,000/µl) and other coagulation abnormalities.
walking away from back pain, one step at a time

Conditions: Low Back Pain

Summary: this study will investigate if a 12-week, individually-tailored walking program, using pedometers will be a more clinically and cost-effective option for the management of chronic low back pain than standardized advice and education.

specific objectives of the study are: 1. to determine perceived levels of disability and baseline levels of walking activity in a sample of those with chronic low back pain (clbp) 2. to determine the uptake and adherence to a pedometer-driven walking program for people with clbp 3. to test the clinical and cost-effectiveness of a walking programme to improve outcomes for clbp compared to a standardized back care education package 4. to test the feasibility of a walking programme in a sub-sample of rural saskatchewan farmers/agricultural workers.

Eligibility criteria:
inclusion criteria: * males and females aged 18 years or over, * experiencing low back pain (i.e. between the 12th costal margin and gluteal fold with or without associated leg pain) persisting for a minimum of three months, and * assessed as capable of participating in a walking programme. exclusion criteria: * any spinal surgery in the past 12 months; * evidence of nerve root, spinal cord, or cauda equina compression; * severe spinal stenosis indicated by signs of neurogenic claudication, grade 3 to 4 spondylolisthesis, fibromyalgia, or systemic/inflammatory disorder; * as well as any other current lower extremity musculoskeletal injury or contraindication to increasing physical activity (pa) levels. the latter may include: * any cardiorespiratory or other medical condition limiting exercise tolerance; * history of serious psychological or psychiatric illness (mild depression eligible for inclusion); and/or * pregnancy.

Keywords: walking pedometer
evaluation of sinetrol® xpur in fat mass reduction on overweight and obese subjects

Conditions: Change in Total Body Fat Mass Percentage Loss Versus Body Weight

Summary: this study aims to evaluate effects of a 16-week supplementation with a polyphenol rich extract, sinetrol® xpur, on fat mass accumulation and body weight management improvement.subjects were overweight or obese and received polyphenol supplement or placebo. a 4-week follow-up as performed to evaluate its effect after supplementation stop.


Eligibility criteria:
inclusion criteria: * overweight or obese (25 kg.m-2\<bmi\<42.5kg.m-2) * healthy exclusion criteria: * metabolic or chronical disease with treatments (i.e.: diabetes, dyslipidemia, thyroiditis, inflammatory disease, immunological disease, infectious disease, asthma, anxiety and depression) * food allergy to the ingredients of the product (grapefruit, orange, caffeine, guarana) * involved in the prior 6 months in a chronic treatment program, eating disorders history, subjected to weight reduction by surgery * start or quit smoking, high alcohol consumption * pregnant, breastfeeding, wanting to have a baby, * menopausal women
roflumilast as an adjunct to antidepressants in major depressive disorder patients

Conditions: Depressive Disorder, Major

Summary: major depressive disorder (mdd) is one of the most common psychiatric disorders with serious socioeconomic consequences on daily life and health care costs. despite the advent of newer antidepressants that target monoamine pathways, nearly 50% of patients have no response to first-line antidepressant therapy. thus, a combination of medications with different strategies at the beginning of treatment could provide further therapeutic benefits to mdd patients


Eligibility criteria:
inclusion criteria: 1. patients with age greater than 18 years old. 2. patients with ham-d score at least 18 with item 1 depressed mood scored 2 or greater are eligible. exclusion criteria: 1. patients with bipolar i or bipolar ii disorder; eating disorders, personality disorders, and mental retardation, current diagnosis anxiety disorders (except for specific phobia), mental disorder due to general medical condition; met criteria for substance dependence or abuse in the previous three months; have a concurrent medical illness or history of seizures that would contraindicate use of the study medication and are receiving electroconvulsive therapy (ect). 2. pregnant women or women not using medically accepted means of birth control are excluded. 3. persons who score greater than 2 on the suicide item of the ham-d, or who are judged to have significant suicidal ideation or potential in the view of an investigator, are excluded. 4. patients who are required to be free of all psychotropic except for escitalopram and anti-inflammatory medications for at least four weeks before study entry.
study to investigate pharmacokinetics, safety and efficacy of sofosbuvir/velpatasvir/voxilaprevir (sof/vel/vox) fixed dose combination (fdc) in adolescents and children with chronic hepatitis c virus (hcv) infection

Conditions: Hepatitis C Virus Infection

Summary: the primary objective of this study is to evaluate the steady-state pharmacokinetics (pk) and confirm the age-appropriate dose of sofosbuvir/velpatasvir/voxilaprevir (sof/vel/vox) fixed-dose combination (fdc) in pediatric participants with chronic hepatitis c virus (hcv) infection.

participants will receive placebo to match sof/vel/vox fdc to assess ability to swallow tablets at screening up to day 1.

Eligibility criteria:
key inclusion criteria: * consent of parent or legal guardian required * chronic hcv infection * screening laboratory values within defined thresholds * individuals must have a determination of prior treatment status: * daa-naive is defined as either: * treatment naive with no prior exposure to any interferon (ifn), ribavirin (rbv), or approved or experimental hcv-specific daa * treatment experienced with an ifn-based regimen and no prior exposure to an approved or experimental hcv-specific daa * daa-experienced is defined as prior exposure to a regimen including any daa (eg, non-structural protein (ns)3/4a protease inhibitor, ns5a inhibitor, or ns5b nucleotide/nucleoside inhibitor) key exclusion criteria: * history of clinically significant illness or any other medical disorder that may interfere with subject treatment, assessment or compliance with the protocol * co-infection with human immunodeficiency virus (hiv), acute hepatitis a virus (hav) or hepatitis b virus (hbv) * clinical hepatic decompensation (eg, clinical ascites, encephalopathy, and/or variceal hemorrhage) * pregnant or nursing females * known hypersensitivity to study medication * use of any prohibited concomitant medications as within 28 days of the day 1 visit note: other protocol defined inclusion/exclusion criteria may apply.