Kornimate/medical-research-clean huggingface dataset:
pattern and surgical treatment of parotid gland neoplasms

Conditions: Parotid Gland Neoplasm

Summary: in these study we analyze pattern of parotid gland neoplasms according to histopathological types, most common type clinical presentation and type of surgical treatment(superficial parotidectomy or total parotidectomy radical parotidectomy

aim of study is to analyze pattern of parotid glands neoplasms in upper egypt as regard 1)age 2) sex , 3) clinical presentation :symptom (parotid lump, pain and facial nerve paralysis) and sign (tenderness, fixation of parotid lump and presence of lymph nodes) 4)histopathological types:(benign or malignant 5)surgical options :superficial parotidectomy, total parotidectomy or radical parotidectomy 6)postoperative complications :facial nerve dysfunction, fistula ,recurrence 7) mortality rate all data will be recorded, tabulated , and statistically analyzed .

Eligibility criteria:
inclusion criteria: * all patient with parotid neoplasm with any age and sex at the period between may2015 to may2021 presented in upper egypt enrolled in this study all the data will recorded ,tabulated and statistically analyzed emphasizing on: 1) age. 2)sex. 3)clinical presentation: symptoms (parotid lump ,pain and facial nerve paralysis * sign (tenderness ,fixations of parotid lump and presence of lymph nodes) . 4)surgical options : - superficial parotidectomy (partial superficial parotidectomy or formal superficial parotidectomy) . * total parotidectomy . * radical parotidectomy. 5)postoperative complications: facial nerve dysfunction, fistula , recurrence) . 6) mortality rate. exclusion criteria: no exclusion criteria

Keywords: parotid
quality of life and symptom management in patients with bladder cancer

Conditions: Bladder Cancer

Summary: rationale: learning about quality of life and symptom management in patients with bladder cancer may help doctors learn about the effects of treatment and plan the best treatment. purpose: this clinical trial is studying of quality of life and symptom management in patients with bladder cancer.

objectives: primary * to identify aspects of health-related quality of life (hrqol) and symptom management in patients with non-invasive, low- or high-risk bladder cancer. * to obtain feedback on data collection methods to enhance acceptability in these patients. outline: patients undergo a 10-minute screening in person or by phone to obtain demographic data and medical information (e.g., bladder cancer diagnosis and treatment history). additional information is obtained from the clinical databases at the baylor college of medicine and the michael e. debakey veterans affairs medical center. patients who are eligible for the study are added to a waiting list for 1 of 4 focus groups based on disease status (high-risk or low-risk non-invasive bladder cancer) and gender. patients participate in a 1.5- to 2-hour focus group discussion about the impact of bladder cancer on their quality of life and relationships. patients receive information about community and internet-based resources at the end of each group session.

Eligibility criteria:
disease characteristics: * diagnosis of bladder cancer within the past 4 years * non-invasive disease * low- or high-risk disease * recruited from patients at the baylor college of medicine scott department of urology clinics, the michael e. debakey veteran affairs medical center, and the urology clinic at md anderson cancer center or from participants at a community event patient characteristics: * not pregnant * able to read, speak, and understand english prior concurrent therapy: * not specified

Keywords: stage 0 bladder cancer
oral health promotion program for persons with severe mental illness

Conditions: Evaluate the Effects of an Oral Health Promotion Program

Summary: a cluster randomized controlled study was carried out in chronic psychiatric wards of a general hospital in central taiwan. sixty-eight eligible male individuals admitted to 2 wards were randomly assigned to an experimental and a control group. participants in the experimental group underwent an oral health promotion program that consisted of biweekly group education sessions, and a 12-week individual behavioral modification for oral hygiene course. the participants in the control group received usual care only. dental plaque (measured by the plaque control index) was examined by a single dentist before and after the experiment.


Eligibility criteria:
inclusion criteria: * patients admitted in chronic psychiatric wards were eligible. exclusion criteria: * significant cognitive disabilities, severe hearing impairment, orthodontic appliances, an edentulous status, or a handicap when tooth-brushing

Keywords: oral health, promotion program, plaque index, mental illness
the influence of technology, education and psychological support on metabolic control in children with t1d

Conditions: Type 1 Diabetes

Summary: the first purpose of this study is to is to compare metabolic control of type 1 diabetes among children under the age of 7 years who use an insulin pump and a real-time (rt) glucose sensor, and children who use only insulin pump; the investigators will also determine dietary habits, their knowledge of type 1 diabetes management and emotional aspects of experiencing illness in the family, in both groups of children.


Eligibility criteria:
inclusion criteria: * age up to 7 years * insulin pump for at least 6 months * more than 6 months of duration of type 1 diabetes * complete remission * normal blood pressure for age, only therapy insulin. exclusion criteria: * age over 8 years * type 1 diabetes less than 6 months * insulin pump less than 6 months * still in remission * associated diseases on drug therapy, high blood pressure

Keywords: type 1 diabetes among young children, sensor, insulin pump, education, psychological support
italian survey on paediatric and neonatal mri

Conditions: Cerebral Disorders Congenital; Premature Birth

Summary: paediatric anaesthesia care in the magnetic resonance imaging is a challenge for clinicians. the recent debate about the role of anaesthetic agent on neural development, encouraged an evaluation of their actual activity in this environment. in this active call survey, the authors sought to delineate the italian situation regarding national centers, staff involved, monitoring and tools available. the primary aim was to evaluate clinical practice in childhood management in magnetic resonance suite. this study was designed as prospective phone survey on the setting of a complete sample of all national centers performing almost a paediatric discharge in the 2014, obtained from italian health ministery registers. the three section survey was fill out with the physician in charge in magnetic resonance suite. the main outcome was a descriptive and exploratory analyses about the organization setting of the centers (procedures, performers, monitoring and tools).


Eligibility criteria:
inclusion criteria: * uncooperative children \< 14 years old * premature babies exclusion criteria: . collaborating children
implication of metformin plus aromatase inhibitor in obese postmenopausal breast cancer women

Conditions: Metformin; Breast Cancer

Summary: metformin is an anti-diabetic oral hypoglycemic agent that considered the gold standard therapy for the treatment of type 2 diabetes. retrospective analyses show that metformin can offer therapeutic benefits to patients with several forms of cancer. it also has positive weight reducing effect on non-diabetic patient by improving insulin sensitivity (although the exact underlying pathomechanisms remain to be elucidated).

this prospective controlled study aimed to evaluate the effect of combined metformin adjuvant therapy and aromatase inhibitors (letrozole) in postmenopausal obese breast cancer women. in addition, to evaluate the effect of weight reduction on aromatase inhibitor efficacy. patients and methods: from february 2014 to june 2015, 75 post-menopausal breast cancer females' patients were recruited, 53 patients underwent randomization and 45 patients completed six months, treatment. aromatase inhibitor (letrozole) was administered as once daily in accordance to one of the three groups. control group: fifteen obese females who received letrozole only; metformin group: fifteen obese females who received the same dose of letrozole plus metformin (2000 ± 500) mg daily, and lean group: fifteen non- obese breast cancer females who received letozole for six months, treatment period. blood samples were collected at baseline and after six months of aromatase inhibitors treatment for analysis of serum estradiol, osteocalcin, insulin, leptin, lactate and glucose.

Eligibility criteria:
inclusion criteria: * postmenopausal women, postmenopausal is defined either by: a. age ≥ 55 years and one year or more of amenorrhea. b. age \< 55 years and one year or more of amenorrhea, with an estradiol assay \< 20 pg/ml. • patients with breast cancer indicated for hormonal treatment with aromatase inhibitors (overweight 30 \> bmi ≥ 25, obese bmi ≥ 30 kg/m2 and non obese bmi between 18 and 25 kg/m2). exclusion criteria: * • diabetic patients. * patients with metabolic syndrome. * patients with last menstrual cycle less than one year ago. * patient with conditions predispose to acidosis (heart failure, renal failure). * ovarian radiation treatment with luteinizing hormone-releasing hormone (lh-rh) agonist (goserelin acetate or leuprolide acetate) is not permitted for induction of ovarian suppression.
study evaluating etanercept in 3 subtypes of childhood arthritis

Conditions: Arthritis, Juvenile Idiopathic

Summary: this study will evaluate the effect of etanercept on the clinical benefit, safety, and physical functioning (ability to function in daily life) in children and adolescent subjects with 3 subtypes of childhood arthritis.


Eligibility criteria:
inclusion criteria: * male and female subjects with a diagnosis per international league of associations for rheumatology (ilar) criteria of extended oligoarticular juvenile idiopathic arthritis (jia) between the ages of 2 and 17 years; enthesitis-related arthritis (era) between the ages of 12 and 17 years; or psoriatic arthritis (psa) between the ages of 12 and 17 years. * \>= 2 active joints and the following for the relevant jia subtype: extended oligoarticular jia or psa with a history of intolerance or an unsatisfactory response to a disease modifying antirheumatic drug (dmard); or era with a history of intolerance or an unsatisfactory response to a nonsteroidal anti-inflammatory drug (nsaid) or a dmard. exclusion criteria: * systemic jia, persistent oligoarticular jia, polyarticular jia, or undifferentiated arthritis per ilar criteria. * other rheumatic diseases. * active uveitis within 6 months of the baseline visit. * any other significant health problem.
physiotherapy for children with dysfunctional breathing

Conditions: Dysfunctional Breathing

Summary: dysfunctional breathing in children primarily affects the ability to participate in sport or exercise but can also stop children doing other activities such as playing musical instruments. clinical experience has shown that physiotherapy (through the use of breathing retraining and other associated techniques) can stop the symptoms of dysfunctional breathing, allowing children to return to normal activities and reduce or stop inhaled medications. whilst there is some evidence in adults with this condition to support the use of physiotherapy, there have been no studies carried out in children investigating whether physiotherapy is beneficial for children with dysfunctional breathing. this study therefore aims to investigate the feasibility of a future large scale multicentre clinical trial designed to investigate whether physiotherapy improves outcomes for children with dysfunctional breathing. the improved management of this common but under recognised condition would lead to significant improvements in the quality of life of children coupled with the reduction in potentially harmful medications.


Eligibility criteria:
inclusion criteria: aged 8-16 years clinical diagnosis of dysfunctional breathing exclusion criteria: uncontrolled comorbidities participant and parents/guardians not fluent in written and spoken english inability to follow instructions
testing trust depression management intervention

Conditions: Depressive Symptoms; Quality of Life

Summary: this study evaluates the effectiveness of a novel depression self-management intervention in adolescents with depression.

half of participants will receive a traditional depression self-management intervention, while the other half will receive the novel depression self-management intervention. in an exploratory, pilot 2-group randomized controlled trial (rct), 16 adolescents were followed over 6 months. data were collected at baseline, 3 months, and 6 months.

Eligibility criteria:
inclusion criteria: * lives in the cleveland metro area * ages 14-17 years old * reports moderate depressive symptoms * able to read, speak, and understand the english language exclusion criteria: * current suicide risk * diagnosis with bipolar disorder, schizophrenia, or a personality disorder * severe behavioral problems that preclude group participation (as reported by parent) * family plans to move from the region within 6 months

Keywords: adolescent parent
effect of lap-band induced weight loss on serum psa levels

Conditions: Obesity; Prostate Cancer

Summary: the proposed prospective study aims to determine whether interpretation of psa levels in morbidly obese men require correction due to the obesity itself. if psa levels are found to rise after weight loss, interpretation of psa levels in morbidly obese men may be improved by upward correction of the psa level. a 'correction factor' may be proposed for the interpretation of psa levels in obese men, toward the clinical decision regarding indication for prostate biopsy.

the main objective of this study is to determine whether interpretation of psa levels in morbidly obese men require correction due to the obesity itself. secondary outcome measures that will be followed include the affect of obesity and weight loss on testosterone, estradiol and leptin. in as much as these might also affect psa, we will be measuring these values as well. also, we do not know the effects of lap-band induced weight loss on clinical outcome measures of sexual, bowel and urinary function. thus we will aim to investigate these parameters as well.

Eligibility criteria:
inclusion criteria: * obese men undergoing lap-band surgery exclusion criteria: * prior diagnosis of prostate cancer * prior prostate surgery * use of 5-alpha reductase inhibitors * history of prostatitis * recurrent urinary tract infection (uti).

Keywords: obesity psa prostate cancer
brimonidine 0.1% versus brinzolamide 1% as adjunctive therapy to latanoprost 0.005%

Conditions: Glaucoma; Ocular Hypertension

Summary: patients with glaucoma or ocular hypertension currently being treated with latanoprost 0.005%, and in need of additional iop lowering will be randomized to receive either brimonidine 0.1% or brinzolamide 1% three-times daily as adjunctive therapy to latanoprost 0.005%


Eligibility criteria:
inclusion criteria: * glaucoma or ocular hypertension in both eyes * currently being treated with latanoprost 0.005% qd * iop greater than or equal to 18mm hg on latanoprost 0.005% * best-corrected va of 20/200 or better in each eye * visual field within 6 months of study entry exclusion criteria: * secondary glaucoma * active intraocular inflammation or macular edema * intraocular surgery or laser surgery within the past 3 months
study to evaluate the effects of the cooling bolero in women with common menopause symptoms

Conditions: Menopause Symptoms

Summary: the cooling bolero is a a vest filled with a new material (not ice or a gel) that provides controlled cooling by absorbing heat. the vest is manufactured by nanohealth. it intended to provide moderate cooling (\~15c/59f) through indirect contact with the skin. the material in the device is safe, non-toxic, and eco-friendly. recent anecdotal studies of women with common peri-menopausal and menopausal symptoms (hot flashes, night sweats, flushing/sweating of face and neck, and intermittent sleep disturbances) have shown a reduction in both the frequency and intensity of those symptoms after using the cooling bolero. specific (moderate) temperature cooling of the neck and upper torso appears to target and mitigate these common menopausal symptoms. this pilot study attempts to collect additional data on the effects of the cooling bolero.

participants who have consented for this study will first be asked to complete a baseline assessment of their menopausal symptoms, including documentation of their baseline weight. if the assessment indicates that the participant has at least 'moderate' menopausal symptoms, then she will then enter the run-in period. during the two-week run-in period, participants will use a symptom diary for to document the frequency and severity of their menopausal symptoms. at the start of week 3, participants will return their completed run-in period symptom diary and receive their cooling bolero with instructions on how to use the product during the treatment period. during the treatment period, participants should use the cooling bolero at least two times per day (morning and evening) for one hour. as feasible, the participant should start to wear the product 30 minutes prior to meal time for these two applications. the participant may also wear the product at additional times, as desired. all applications of the cooling bolero during the four-week treatment period are to be documented in the product/symptom diary. during the treatment period, the participant will also continue to document the frequency and severity of their menopausal symptoms in the product/symptom diary. at the end of week 6, the participant will stop using the cooling bolero. she will be asked to complete a product assessment and have her weight documented. participants will be contacted at week 10 to ask about the status of menopausal symptoms after four weeks of not using the cooling bolero.

Eligibility criteria:
inclusion criteria: * female, who is at least 18 years old. * self-reports having at least two (2) daily hot flashes associated with menopause. exclusion criteria: • has another existing medical condition that would prevent study compliance.
olfaction in patients with parkinson's disease following treatment with rasagiline

Conditions: Parkinson´s Disease

Summary: there is convincing evidence from numerous studies using both psychophysical and electrophysiological approaches that olfaction is markedly reduced in parkinson´s disease (pd). data on the prevalence of olfactory dysfunction in pd however, range from 45% and 49% in the pioneering studies of ansari \& johnson, and ward, respectively, up to 74% in the work of hawkes et al., or as high as 90% in a study published by doty et al. quality of life, safety, and interpersonal relations, as well as food behavior/nutritional intake are severely altered in a large proportion of patients with olfactory loss. thus, the same can be assumed in patients with parkinson's disease. if it was possible to improve olfactory function this would appear as a significant effect in patients with parkinson's disease. provided the study would reveal an improvement of olfactory function following therapy with rasagiline, this would have tremendous worldwide impact on the use of this drug. considering the frequency of pd a very large number of patients would benefit from these findings, especially in terms of quality of life.


Eligibility criteria:
inclusion criteria: * parkinson´s disease, hoehn \& yahr stage ≤ iii * aged 18-64 yrs * hyposmia/functional anosmia defined as tdi\<30 * written consent exclusion criteria: * congenital olfactory loss * significant infections of the nose and nasal sinuses * diseases/states apart from pd which may significantly affect olfactory function, e.g., asthma, head trauma etc. * dementia, psychiatric illness, addictive behaviour * smoker * severe liver disease * pregnant or breastfeeding women * any contraindication for the treatment with rasagiline * women without reliable contraception

Keywords: parkinson´s disease olfaction rasagiline smell testing
preoperative bnp and mins in aaa open repair

Conditions: Myocardial Injury After Non-cardiac Surgery

Summary: the aim of this study was to investigate whether preoperative b-type natriuretic peptides serves as an independent predictor of myocardial injury after non-cardiac surgery (mins) in abdominal aortic aneurysm open repair.

the incidence of mins was compared between the lower bnp and higher bnp groups, and a stepwise logistic regression analysis was performed to evaluate the predictors for mins.

Eligibility criteria:
inclusion criteria: patients who underwent open repair with aaa from september 2010 to october 2021 exclusion criteria: 1. ruptured aaa 2. traumatic aortic injury 3. absence of troponin-t value within 30 days of surgery 4. diagnosis of elevation of troponin-t due to non-ischemic cause (ex: sepsis, pulmonary embolism, atrial fibrillation, cardioversion, etc.) 5. insufficient medical records

Keywords: aaa mins bnp
hepatotoxicity of antituberculosis therapy (hat) study

Conditions: Chemical and Drug Induced Liver Injury

Summary: drug-induced liver injury (dili) is a common side effect in antituberculosis therapy, which interuputs the treatment of tb and leads to a higher proportion of multidrug-resistence tb(mdr-tb).the study primalily aims to observe the proportion of dili in antituberculosis therapy. furthermore, the secondary objective is to study the proportion of liver injury of based liver disase,liver failure and adjustment of chemotherapy in the obersevational study.

drug-induced liver injury (dili) is a common side effect in antituberculosis therapy, which interuputs the treatment of tb and leads to a higher proportion of multidrug-resistence tb(mdr-tb).the study primalily aims to observe the proportion of dili in antituberculosis therapy. furthermore, the secondary objective is to study the proportion of liver injury of based liver disase,liver failure and adjustment of chemotherapy in the obersevational study.

Eligibility criteria:
inclusion criteria: * 1) patients who are about to start anti-tuberculosis treatment 2) male or female, age \> 18 years old 3) voluntary signing of "subject informed consent form" exclusion criteria: - 1)a history of taking anti-tuberculosis drugs within 6 months before the treatment; 2)abnormal liver function before starting anti-tuberculosis treatment; 3)dili at the time of enrollment. 4)combined with malignant tumors (including hematological tumors), hiv infection, etc. 5) according to the investigator's judgment, patients who cannot complete this study or who cannot comply with the requirements of this study.

Keywords: hepatotoxicity of antituberculosis therapy dili
effects of pilates-based therapeutic exercises on the postural control

Conditions: Motor Disorders

Summary: the pilates method (pm) has been widely used in the daily practice of many professionals. it is well known that anticipatory postural adjustments (apas) have a strong relation with the improvement in performance through motor control improvement. however, no studies have investigate the pm exercises performed with pelvis in different positions on the improvement of performance, apas and these influences on motor control. this study aims to compare the effects of practicing a single session of pilates-based therapeutic exercises with posterior pelvic tilt and neutral position of the pelvis on the apas of elderly subjects.


Eligibility criteria:
inclusion criteria: * no history of previous abdominal or spine surgery in the last two years * no history of low back pain in the past 2 years (as incapacitate pain lasting at least seven days) * no neurological disorder diagnosis exclusion criteria: * significant postural asymmetry (misalignment that exceed 2 cm of the anterior superior iliac spine)