Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of erector spinal plane block (espb) for analgesia in laparoscopic cholecystectomy

Conditions: Analgesia

Summary: purpose: to evaluate the efficacy and safety of erector spinal block (esb) for analgesia in laparoscopic cholecystectomy（lc）. method: this study is a randomized, single-blind, controlled clinical trial. pre-operative ultrasound-guided bilateral erector spinae plane block will be performed in the espb group. vertebral side block will be performed in the vsb group. and the control group will receive local anaesthesia after the surgery. intraoperative and postoperative analgesia effect and side effects will be compared between the three groups.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status 1-3 * scheduled for elective laparoscopic cholecystectomy surgery under general anesthesia exclusion criteria: * patient refusal * pregnancy * history of allergy to study drugs * neurological and cognitive disorders * coagulopathy * chronic pain disorders * infections at the injection site * history of abdominal surgery

Keywords: erector spinal plane block analgesia laparoscopic cholecystectomy
the use of low molecular weight heparin in hemodiafiltration

Conditions: Chronic Kidney Disease

Summary: low molecular weight heparin (lmwh) is injected in the dialysis circuit at the start of the session. in the present study we compare 3 different methods of injection of lmwh: parameters of dialysis efficiency and clotting are measured. the study lasts 3 sessions for each patient.


Eligibility criteria:
inclusion criteria: * chronic kidney disease stade v treated with hemodiafiltration * age \>18 year * hematocrit \> 30% exclusion criteria: * treatment with vitamin k antagonists * treatment with other anti-coagulants or heparin besides the heparin used during dialysis * active bleeding, infection or malignancy * heparin associated allergy * hepatic failure * trombocytopenia \< 120.000/µl

Keywords: stage v treated hemodiafiltration
macular pigment density evolution in unilateral wet amd versus non amd patients with or without lutein and zeaxanthine supplementation

Conditions: Exudative Age-related Macular Degeneration

Summary: •purpose: age-related macular degeneration ( amd) is the leading cause of blindness and visual impairment in industrialized countries. the macular pigment, composed of carotenoid derivatives (lutein and zeaxanthin), may play an important role in the occurrence of amd. an increase in macular pigment following dietary supplementation with lutein and zeaxanthin could allow early treatment with such supplements in subjects with a high risk of amd, and encourage them to change their eating habits. •primary outcome: comparative analysis of the density and evolution of the density of macular pigment: * in patients without any retinal pathology who underwent cataract surgery 1 month previously * in the non-exudative eye of patients with exudative amd in one eye by analyzing the density and evolution of the density of macular pigment in the non-exudative eye * secondary outcomes: analysis of changes in macular pigment density after taking food supplements (nutrof total versus comparator): * time taken to reach the maximum plateau of macular pigment density (no increase in density between 2 measurements) * time taken to return to the baseline macular pigment density after cessation of supplementation * study design : pilot study -prospective, randomised, double-masked, comparative, multicenter.


Eligibility criteria:
inclusion criteria: * both genders (male or female), ≥ 55 years of age. * patients without any retinal pathology who underwent cataract surgery 1 month previously or * patients with neovascular amd (age-related macular degeneration) in one eye. * patients who gave their written consent exclusion criteria: exclusion criteria related to the study: * intolerance to the tested product * change in fundus image * patients already taking nutrof total or similar supplements containing lutein and zeaxanthin * allergy to mydriatics exclusion criteria for ophthalmologic reasons: o ocular diseases or conditions whose presence might interfere with the measurement of optical density of macular pigment (e.g. cataract, diabetic retinopathy, optic atrophy, myopia\> -6.5 diopters) exclusion criteria for systemic reasons: o medical or surgical history, disorder or disease (e.g. severe organic disease, acute or chronic: liver disease, endocrine, neoplastic, hematologic, infectious diseases, severe psychiatric disorder, significant cardiovascular abnormalities, etc...) and / or aggravating factors or structural defect, considered as being inconsistent with the study by the investigator. exclusion criteria for general reasons: * inability of the patient to understand the study procedures and to give informed consent. * ward of court * patient not covered by the social security scheme * pregnancy

Keywords: exudative amd dietary supplements macular pigment lutein zeaxanthin nutrof total in one eye
virtual health focused acceptance-based program for parents and youth

Conditions: Pediatric Obesity; Executive Function

Summary: the main purpose of vhappy is to pilot test a new type of virtual family-based healthy lifestyle program for children aged 8-14 with obesity and their caregivers. vhappy aims to (1) transition a previously developed acceptance-based behavioral treatment to web-based platform, utilizing qualitative and quantitative program evaluation data from past participants. (2) determine the feasibility, acceptability, and preliminary outcomes of the adapted web-based treatment. (3) evaluate whether the adapted web-based treatment (self-guided treatment + brief coaching) is similar to the traditional treatment (interventionist-guided treatment) in terms of feasibility, acceptability, and preliminary outcomes utilizing a non-randomized sequential arm design.

caregiver and child pairs will complete a 14 week virtual, self-guided healthy lifestyle program including education on health and wellness topics such as food groups, physical activity and stress management. special skill builders for managing the thoughts, feelings and emotions associated with changing health behaviors will also be included. pairs will have biweekly 15 minute coaching sessions to check in on progress in the past week, set goals and problem solve. optional group sessions will be offered for peer support. in order to assess progress, pairs will also complete assessment visits before and after the program. these visits include one virtual assessment via zoom and one in-person assessment at the university of alabama at birmingham. caregivers and children will complete questionnaires and measures such has height, weight, blood pressure and a finger prick.

Eligibility criteria:
inclusion criteria: children who: 1. have a bmi ≥ 85th percentile; 2. are 8 and 14 years old at the beginning of treatment; 3. can read, write, and speak english, along with their caregiver; 4. plan to stay living in the local area during the study period; 5. have a consenting caregiver who can commit to all study procedures. exclusion criteria: children who: 1. have been diagnosed with a medical condition and/or are taking medication known to affect appetite/weight, physical activity level or executive function; 2. are currently participating in a formal weight management program beyond usual medical care or have a caregiver participating in a formal weight management program.

Keywords: pediatric obesity executive function behavioral intervention acceptance based
effect of neutrophil elastase inhibitor on lung injury after esophagectomy

Conditions: Esophageal Cancer

Summary: a neutrophil elastase inhibitor may have effect on suppression of the lung injury after thoransthoracic esophagectomy. the investigators hypothesized that postoperative complication, particularly respiratory complication may be reduced by neutrophil elastase inhibitor after esophagectomy.

the aim of this study was to clarify the usefulness of perioperative administration of sivelestat sodium hydrate, a selective inhibitor of neutrophil elastase in the pulmonary function, systemic inflammatory response, and the postoperative clinical course following video-assisted thoracoscopic esohpagectomy for esophageal cancer.

Eligibility criteria:
inclusion criteria: * thoracic esophageal squamous cell carcinoma exclusion criteria: * preoperative chemoradiotherapy * cardiovascular disease with nyha grade iii or iv * pulmonary disorder with hugh-jones classification ii, iii, iv, or v, preo * liver cirrhosis * renal failure

Keywords: esophagectomy postoperative respiratory complications neutrophil elastase inhibitor
educational program to improve heart failure outcomes in adults living in rural areas

Conditions: Heart Failure, Congestive

Summary: heart failure patients living in rural areas usually do not have adequate access to formal heart failure management programs. this study will compare two versions of an educational intervention aimed at improving self-care management techniques among individuals with heart failure who are living in rural areas.

heart failure is a life-threatening condition in which the heart can no longer pump enough blood to the rest of the body. it is important for individuals with heart failure to closely monitor their symptoms and seek out medical attention when appropriate. swelling and weight gain are common heart failure symptoms that indicate excess fluid buildup in the body and worsening heart function. closely monitoring and responding to these symptoms can be a strategic way to prevent heart failure exacerbations. however, many patients ignore symptoms and are reluctant to seek care. specialized monitoring programs can help heart failure patients to respond more appropriately to their symptoms. traditionally, heart failure patients living in rural areas have had limited access to formal monitoring programs. fluid watchers is a program designed to help heart failure patients living in rural areas improve self-management of symptoms, specifically excess fluid buildup. the purpose of this study is to compare the effectiveness of two versions of fluid watchers at improving the hospitalization and death rates of individuals with heart failure who live in rural areas. in this 2-year study, 710 participants will be randomly assigned to either the fluid watchers lite program, the fluid watchers plus program, or a usual care control group. individuals in both fluid watchers groups will attend a one-on-one educational session that will include heart failure counseling and information on self-monitoring and care-seeking strategies. participants in the plus program will receive additional counseling, audio tapes, and follow-up telephone calls on a biweekly basis. all participants will record self-monitoring adherence and contact with healthcare providers. outcome measures will be assessed during either clinic or home visits at study entry and months 3, 12, and 24, and will include number of emergency department visits, number of physician visits, heart failure severity, and quality of life.

Eligibility criteria:
inclusion criteria: * hospitalized for heart failure in the 6 months prior to study entry * able to read and write english * lives independently exclusion criteria: * current participation in a heart failure management program * impaired cognition * serious co-morbidity

Keywords: heart failure patient education
unexplained infertility treated by hysteroscopy-laparoscopy

Conditions: Unexplained Infertility

Summary: retrospective study, including patients from january 2013 to december 2018, who were diagnosed with unexplained infertility : spontaneously ovulating women with normal pelvic ultrasound scan, patent tubes on hysterosalpingography and normal pelvic exam or pelvic mri normal. semen analyses were normal according to the world health organization criteria. couples were referred for diagnostic laparoscopy and hysteroscopy. they were then addressed for spontaneous fertility or art to conceive. the investigators would like to see how many surgeries were useful to assess a diagnostic, and if operating allows a satisfying pregnancy rate. the investigators would like to assess how many diagnosis was done after surgery and how many pregnancy were obtained. the investigators search other prognostic factors than age or parity.


Eligibility criteria:
inclusion criteria: * 18-43y * unexplained infertility * operated from laparoscopy-hysteroscopy at montpellier university hospital exclusion criteria: * an imr that diagnoses formelly an endometriosis, or endometriosic ovarian cysts * any non respect to inclusion criterias * non respect of our definition of unexplained infertility (such as bilateral tubal issue on hysterosalpingograms)

Keywords: ovulation semen analysis tubal patency pelvic ultrasound scan
dexamethasone-implant for the treatment of rvo

Conditions: Macular Edema Caused by Retinal Vein Occlusion

Summary: to evaluate the efficacy and safety of a dexamethasone-implant alone or in combination with bevacizumab. 64 eyes are prospectively investigated. group 1 (22 crvo and 16 brvo) is treated with dexamethasone-implant alone, group 2 (14 crvo 12 brvo) with three consecutive bevacizumab injections followed by a dexamethasone-implant. recurrences are treated with dexamethasone-implant only. patients are seen preoperatively and thereafter in monthly intervals. the primary endpoint was bcva at twelve months.


Eligibility criteria:
inclusion criteria: maximum duration of symptoms of four months and no known history of glaucoma or corticosteroid response in the past - exclusion criteria: glaucoma, diabetic retinopathy, prior ivom, uveitis -
comparing effectiveness of merocel and packing with tranexamic acid in the management of anterior epistaxis

Conditions: Tranexamic Acid; Epistaxis; Nasal Packing

Summary: aim of this study is evaluate whether superior nasal compression with tranexamic acid to simple nasal compression and merocel packing. in this study, patients who presented with non-traumatic anterior epistaxis to emergency departments will be included in this study. three different therapy option are created; first, nasal compression with tranexamic acid, second, simple nasal compression without any drugs. and third, packing with merocel.


Eligibility criteria:
inclusion criteria: * patients with anterior epistaxis older than 18 year and accept to participate in the study exclusion criteria: * patients younger than 18 years * patients who used anticoagulation therapy * patients who have hemodynamically instability * traumatic epistaxis * patients who have known bleeding disorder
japanese bridging study conducted in the united states

Conditions: Hepatitis C Virus

Summary: the purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics following single oral and multiple oral doses bms-791325 in healthy japanese subjects.


Eligibility criteria:
inclusion criteria: * healthy male and female subjects aged 20 to 49 years, with bmi of 18-30 kg/m2 * first generation japanese. subject born in japan and has not lived outside of japan for \> 10 years, and subject can trace maternal and paternal japanese ancestry exclusion criteria: * any significant acute or chronic medical illness. * women who are pregnant, breastfeeding, or unwilling or unable to use an acceptable method of birth control. * gastrointestinal disease that may impact the absorption of study drug or that required treatment with a protocon inhibitor, antacid or h2 blocker. * history of eczema, psoriasis, or any intermittent or active dermatitis. * positive for hiv or hcv
biomagnetic signals of intestinal ischemia

Conditions: Ischemia

Summary: the lack of blood flow to the small intestine causes mesenteric ischemia. using a superconducting quantum interference device (squid) which measures the magnetic field of the small intestine, we are hoping to identify abnormalities without surgical intervention.

the electrical activity of the small intestine may contain important information that will help us diagnose gastrointestinal diseases. the major impediment to reducing mortality of mesenteric ischemia is the lack of a noninvasive diagnostic test that identifies the syndrome before extensive necrosis occurs. mesenteric ischemia is caused by the lack of blood flow to the intestine. the superconducting quantum interference device (squid) measures the magnetic field of the intestinal smooth muscle. by comparing normal smooth muscle and that of patients with mesenteric ischemia, we hope to identify abnormal disease states without surgery.

Eligibility criteria:
inclusion criteria: * normal subjects and those diagnosed with mesenteric ischemia exclusion criteria: * subjects who report a tendency toward claustrophobia

Keywords: blood supply mesentery
assessing efficacy and safety of flexible dosing with vardenafil in subjects with erectile dysfunction and hyperlipidemia

Conditions: Erectile Dysfunction

Summary: this study is being conducted in us to obtain information on the efficacy, safety, and duration of erection of flexible-dose regime of vardenafil compared to placebo (dummy medication with no pharmacological activity), in patients with co-morbid factors associated with erectile dysfunction (also called impotence). the duration of erection endpoint will be assessed by patient utilized stopwatch timings during each attempt at sexual intercourse. elevated levels of total cholesterol or low levels of hdl may result in atherosclerosis and induce erectile dysfunction. vardenafil (levitra) is approved by the food and drug administration for the treatment of erectile dysfunction. while there is no intent to assess the effect vardenafil has on blood lipids, the study will provide prospective data on men diagnosed with both ed and dyslipidemia.


Eligibility criteria:
inclusion criteria: * males with ed for more than 6 months, according to the nih consensus statement (inability to attain and/or maintain penile erection sufficient for satisfactory sexual performance) * stable heterosexual relationship for more than 6 months * between 18 and \<65 years of age * diagnosed dyslipidemia and treated with a stable dose of a statin (or generic equivalent) \>/=3 months at screening. in addition, the subject must have remained on this stable dose of statin (or its generic equivalent) throughout the study and no additional therapy to treat dyslipidemia was initiated * internationai index of erectile function - erectile function domain score of \<25, denoting mild to severe ed at visit 2 exclusion criteria: * primary hypoactive sexual desire * history of myocardial infarction, stroke or life-threatening arrhythmia within prior 6 month * nitrate therapy * other exclusion criteria apply according to the us product information

Keywords: male erectile dysfunction dyslipidemia vardenafil
cystoinflation to prevent bladder injury in obstetrics and gynaecology surgery

Conditions: Bladder Injury; Complications; Cesarean Section; Adhesions Pelvic

Summary: part1:the healthy pregnant women with previous operative deliveries admitted for elective c-section will be counselled and conditioned informed consent will be taken to be included in either study group if dense pelvic adhesions will be found during their operation. adhesiolysis will be performed using bladder retro-fill with 300cc saline in the cystoinflation group, and without retro-fill in control.both groups will be observed for bladder injury rate,bloodloss,operativetime,urinary tract infection,micturition problems and fistula formation. part2\&3:summary of part 2 and 3 will be provided after publication

part1:investigators will conduct this study to find the effectiveness of cystoinflation to prevent bladder injury in women with adhesions of previous c-sections. this prospective analytic longitudinal study will be conducted in lady willingdon hospital, a tertiary care teaching hospital affiliated with king edward medical university pakistan, from august 2017 to july 2019, after approval by the institutional review board of king edward medical university, pakistan. the subjects will be randomly allocated to cystoinflation and control groups. the healthy pregnant women with previous operative deliveries admitted for elective c-section will be counselled and conditioned informed consent will be taken to be included in either study group if dense pelvic adhesions will be found during their operation. adhesiolysis will be performed using bladder retro-fill with 300cc saline in the cystoinflation group, and without retro-fill in control. we will assess primary outcome by observing bladder injury rate, blood loss and operative time. the secondary outcome will be assessed by urinary tract infection, micturition problems and fistula formation during 3month follow up period. the cystoinflation will be considered effective if the proportion of bladder injury in the study group will be less than 50% of the control group. part2\&3:details of part2\&3 will be provided after publication

Eligibility criteria:
part1:inclusion criteria: * • healthy pregnant women of any age * two or more previous c-sections * gestational age between 38-40 weeks (confirmed by dating scan) * dense adhesions of tulandi scores four or more. * women who give informed consent to participate in the study exclusion criteria :• patients with medical disorders * bladder injury before group assignment * placenta previa * subjects experiencing micturition problems (dysuria, frequency, urgency, urinary retention, incontinence) before the study. eligibility criteria of part 2\&3 will be provided after publication -
prediction of postsurgical symptomatic outcomes with preoperative pessary use

Conditions: Vaginal Vault Prolapse; Pelvic Organ Prolapse; Uterine Prolapse; Pelvic Floor Prolapse

Summary: this is a single center, prospective trial of pessary use prior to reconstructive pelvic floor surgery for pelvic organ prolapse. the goal of the study is to evaluate the change in pelvic floor symptoms with pessary use and subsequent reconstructive surgery. additionally, we will assess the impact that preoperative pessary use has on patient self-reported preparedness for surgery.

it is anticipated that this trial will define the clinical utility of routine preoperative pessary placement, and by shaping patient expectations and increasing preparedness for surgery, we anticipate improving satisfaction and quality of life. at the initial office visit baseline symptoms are evaluation with validated questionnaire. the patients' will undergo pessary fitting at least 7 days (but no more than 28 days) prior to scheduled surgical prolapse repair. symptomatic change from baseline will be assessed with validated questionnaire preoperatively. the pessary will be removed at the time of surgery, and the patient will undergo surgical correction of their pelvic organ prolapse (including all restorative surgical procedures, abdominal and transvaginal). a concomitant anti-incontinence procedure will be performed at the discretion of the treating physician in consultation with the patient. the patients' symptomatic outcome from surgery will then be reassessed by validated questionnaire at 6 weeks and 3 months postoperatively.

Eligibility criteria:
inclusion criteria: * older than 18 years of age * with symptomatic pelvic organ prolapse * electing for surgical repair of pelvic organ prolapse (transvaginal or transabdominal) at least 7 days after office consultation * understand and have signed written informed consent for preoperative pessary placement. exclusion criteria: * previous use of a pessary for pelvic organ prolapse * patients undergoing obliterative prolapse surgery (i.e. colpocleisis), * are scheduled for surgery for pelvic organ prolapse less than 7 days after office consultation or greater than 4 weeks after office consultation * have an isolated rectocele * have allergies to both latex and silicone * have an active pelvic infection

Keywords: pessary prolapse cystocele