Kornimate/medical-research-clean huggingface dataset:
prediction of duration of mechanical ventilation in ards

Conditions: Acute Respiratory Distress Syndrome

Summary: the investigators are planning to perform a secondary analysis of an academic dataset of 1,303 patients with moderate-to-severe acute respiratory distress syndrome (ards) included in several published cohorts (nct00736892, nct022288949, nct02836444, nct03145974), aimed to characterize the best early scenario during the first three days of diagnosis to predict duration of mechanical ventilation in the intensive care unit (icu) using supervised machine learning (ml) approaches.

the acute respiratory distress syndrome (ards) is an important cause of morbidity, mortality, and costs in intensive care units (icus) worldwide. most ards patients require mechanical ventilation (mv). few studies have investigated the prediction of mv duration of ards. for model description and testing, the investigators will extract data from he first three icu days after diagnosis of moderate-to-severe ards from patients included in the de-identified database, which includes 1,000 mechanically ventilated patients enrolled in several observational cohorts in spain, coordinated by the principal investigator (jv), and funded by the instituto de salud carlos iii (isciii). the investigators will follow the tripod guidelines and machine learning techniques will be implemented \[random forest (rf), extreme gradient boosting (xgboost), and logistic regression analysis) for the development and accuracy of prediction models. disease progression will be tracked along those 3 icu days to assess lung severity according to berlin criteria. for external validation, the investigators will use 303 patients enrolled in a contemporary observational study (nct03145974). the investigators will evaluate the accuracy of prediction models by calculation several statistics, such as sensitivity, specificity, positive predictive value, negative value for each model. the investigators will select the best early prediction model with data captured on the 1st, 2nd, or 3rd day.

Eligibility criteria:
inclusion criteria: * berlin criteria for moderate to severe acute respiratory distress syndrome exclusion criteria: * postoperative patients ventilated \<24h * brain death patients

Keywords: mechanical ventilation intensive care unit duration of ventilation machine learning.
punchgrafting techniques for vitiligo

Conditions: Non-segmental Vitiligo; Segmental Vitiligo; Piebaldism

Summary: rationale: punch grafting is a safe, simple and widely used technique for in vitiligo. however, no reliable data are available on the effect of punch depth and punch size. objectives: primary: to compare the efficacy and safety of different punchdepths and punchsizes in punch grafting in patients with segmental and non-segmental vitiligo. secondary: to assess the practical aspects and patients preference of different punch grafting techniques. study design: prospective observer blinded randomised controlled study. study population: 35 patients ≥ 18 years with segmental or stable non-segmental vitiligo who will receive regular treatment by punch grafting at the netherlands institute for pigment disorders (snip) at the academic medical centre university of amsterdam. methods: four depigmented regions on the trunk or upper extremities will be randomly allocated to either epidermal 1,5 mm punch grafting, epidermal 1mm punch grafting, dermal 1,5 mm punch grafting and dermal 1 mm punch grafting. after grafting, all regions will receive uv-therapy twice a week for 3 months. three and six months after grafting, the repigmentation of the lesions will be assessed by measuring the outgrowth. main study parameter/endpoint: outgrowth of pigment after six months. nature and extent of the burden and risks associated with participation, benefit and group relatedness: the study involves 16 additional punch grafts but no additional visits to our institute. patients will not miss any regular treatment. the extra time due to participation in the study will be about 40 minutes. no increase of the risk of side effects is expected by placing 16 additional punch grafts. 1.


Eligibility criteria:
inclusion criteria: * patients with non-segmental and segmental vitiligo under medical treatment at the netherlands institute for pigment disorders * age between 18 and 60 years * patient is willing and able to give written informed consent * vitiligo stable since 12 months without systemic therapy or 6 months without topical therapy as defined by the absence of new lesions and/or enlargement of existing lesions. * vitiligo lesions on the extremities or trunk larger than 5x5cm exclusion criteria: * uv therapy or systemic immunosuppressive treatment during the last 12 months * local treatment of vitiligo during the last 6 months * vitiligo lesions with folliculair or non-folliculair repigmentations * skin type 1 * hypertrophic scars * keloid * cardial insufficiency * patients with a history of hypersensitivity to (uvb) light and allergy to local anesthesia. * patients who are pregnant or breast-feeding * patients not competent to understand what the procedures involved * patients with a personal history of melanoma or non-melanoma skin cancer * patients with a first degree relative with melanoma skin cancer * patients with atypical nevi.

Keywords: vitiligo piebaldism punchgrafting minigrafting stable for at least 12 months
evaluation of autonomic function in individuals with cornelia de lange syndrome (cdls)

Conditions: Cornelia de Lange Syndrome

Summary: based on survey data, individuals with cornelia de lange syndrome (cdls) often experience symptoms of autonomic dysfunction however there are no reported studies in which these patients have had objective testing of the autonomic nervous system. this is a pilot study in which patients with cdls will undergo the standard clinical testing for autonomic dysfunction with a autonomic reflex screen and thermoregulatory sweat test.


Eligibility criteria:
inclusion criteria: * pediatric patients (aged 8-17 years of age) with cornelia de lange syndrome. * consent obtained from responsible guardian. exclusion criteria: * patients less than age 8 or 18 and older * female patients known to be pregnant * individuals not thought to be able to tolerate the testing. * concomitant therapy with anticholinergic, alpha-adrenergic antagonists, beta-adrenergic antagonists or other medications which could interfere with autonomic testing. patients may participate if the potentially interfering medication is held for five half-lives prior to the study
a communication strategy for families of patients dying in the icu

Conditions: Family of Dying Patient in the ICU

Summary: decisions to limit life sustaining treatments are made for most patients dying in the icu, usually with input from the family. the well-being of the family may be jeopardized by involvement in the decision-making process and bereavement. we evaluated the ability of a proactive communication strategy (family conference and providing family members with a bereavement information leaflet) designed to improve family well-being.


Eligibility criteria:
inclusion criteria: * family of dying patient exclusion criteria: * family having no enough knowledge of french to respond to telephone interview * patient alive on day 90

Keywords: family end-of-life intensive care unit
neoadjuvant wx-0593 in resectable alk-positive or ros1-positive non-small cell lung cancer

Conditions: Non-Small Cell Lung Cancer(NSCLC)

Summary: this is a single-arm, exploratory trial to evaluate the efficacy and safety of neoadjuvant wx-0593 in patients with resectable alk-positive or ros1- positive non-small cell lung cancer(nsclc).


Eligibility criteria:
inclusion criteria: * histologically confirmed non-small cell lung cancer (nsclc). * alk-positive or ros1-positive nsclc in stage ib-iiia (according to the 8th american joint committee on cancer tnm edition), as assessed by investigator. * complete surgical resection of the primary nsclc must be deemed achievable, as assessed by a mdt evaluation (which should include a thoracic surgeon, specialized in oncologic procedures). * ecog performance status of 0-1. * at least one measurable lesion according to recist 1.1. * adequate organ and marrow function. exclusion criteria: * prior treatment with any systemic anti-cancer therapy for nsclc including chemotherapy, biologic therapy, immunotherapy, or any investigational drug. * prior treatment with alk tki or ros1 tki. * prior treatment with local radiotherapy. * mixed small cell and nsclc histology. * patients who are candidates to undergo only segmentectomies or wedge resections.
leo study unstable asthma

Conditions: Asthma in Children

Summary: this is a prospective, observational study to investigate the agreement of the leo device signal derivation with gold standard asthmatic testing in recently exacerbated asthmatic children. this study is designed for engineering validation of a wireless, wearable device (leo) for assessing clinical control of children recovering from acute respiratory event such as asthma attack. the leo device will monitor chest impedance, ecg and body position to calculate parameters such as respiration rate, heart rate, lung volume, tidal breathing flow and volume curves, and body position. these parameters will then be used to train and algorithm to assess clinical control of asthma.


Eligibility criteria:
inclusion criteria: * children aged ≥2 years old and \<18 years old at time of consent * children with a legal guardian able to sign consent for study participation * children and caregivers able to read and understand english or spanish * children who are currently hospitalized with acute exacerbation of asthma * child's caregiver is able to communicate using sms * child has an asthma inhaler exclusion criteria: * children with complex medical conditions which may hinder their ability to complete protocol assessments * children with an active skin condition involving the area on the chest wall where the leo device will be attached. e.g. inflamed and/or infected eczema or other skin conditions involving the anterior chest wall at the time of recruitment * children with any implanted medical devices, e.g. cardiac pacemaker * children with any history of known allergic reaction to adhesives or hydrogels, as the ones used with the leo device
piloting the iproactif program to preserve functioning and prevent cognitive decline

Conditions: Heart Disease (Coronary Artery Disease, Ischemic Heart Disease, Hypertensive Heart Disease); Uncontrolled Diabetes (HBA1c ≥ 10)

Summary: conduct a pilot randomized control to assess the preliminary efficacy of iproactif, an occupational therapist-delivered primary care intervention for aging and chronic disease management.

the iproactif intervention is based on the premise of preventing the physical and cognitive decline that is associated with aging and chronic disease. the 12-week intervention includes a comprehensive assessment of adl functioning and ten intervention sessions addressing disease management, physical activity and executive functioning. this pilot randomized control trial will compare whether patients who receive iproactif perform better than usual care patients on physical functioning, self-efficacy for chronic disease management, physical activity levels, executive functioning, health-related quality of life, and participation in life roles and activities.

Eligibility criteria:
inclusion criteria: * english speaking * community-dwelling * 55 years of age * primary diagnosis of heart disease (coronary artery disease, ischemic heart disease, hypertensive heart disease), or uncontrolled diabetes (hba1c greater than/equal to 10) * self-reported risk of functional decline (score of 3 or higher) on the 11-item brief risk identification of geriatric health tool or self-reported need for assistance with disease management exclusion criteria * current/past diagnosis of stroke or other neurological disorders * receiving pharmacological treatment for cognition * participating in other exercise or adl-focused intervention studies * non-english speaking * residing in a long-term care institution * compromised decision-making capacity (score \>8 on somct)

Keywords: chronic disease aging physical function executive function activities of daily living primary care
a study evaluating the clinical outcome of a modified d'hoore technique for laparoscopic ventral mesh rectopexy

Conditions: Rectocele; Enterocele; Rectal Prolapse

Summary: the purpose of this observational study is to evaluate the clinical outcome of a modified d'hoore technique for laparoscopic ventral mesh rectopexy in patients with primary rectal prolapse, rectocele and/or enterocele.the goal of the study will be achieved by reporting the peri- and postoperative complications ((serious) adverse events), recurrences and re-interventions. pre-operative to postoperative changes in pain, functional outcome and quality of life will be evaluated as well.


Eligibility criteria:
inclusion criteria: * female patients. * patient ≥ 18 years of age at study entry. * patient and investigator signed and dated the informed consent form prior to the index-procedure. * patient with primary rectal prolapse (grades i to v according to the oxford scale), rectocele and/or enterocele. exclusion criteria: * patient is unable / unwilling to provide informed consent. * patient with recurrent rectal prolapse, rectocele and/or enterocele. * patient is unable to comply with the study protocol or proposed follow-up visits. * patient has a contra-indication for laparoscopic ventral mesh rectopexy.
chronic post surgical pain-cardiac

Conditions: Chronic Post-surgical Pain

Summary: the cpsp-cardiac is a large, multi-center, observational study with the aim to investigate the incidence of chronic pain in the 3rd month postoperatively in cardiac surgery and its affecting factors.

cardiovascular diseases pose a significant global health concern, particularly among the elderly population, leading to a surge in surgical interventions. enhanced recovery after surgery (eras®) protocols, specifically eras® cardiac, target improved perioperative pain management to optimize patient outcomes. effective pain control aims to alleviate acute discomfort, prevent chronic pain development, facilitate early mobilization, reduce hospital stays, and enhance patient satisfaction and functional recovery. while pain intensity peaks within the initial days following cardiac surgery and gradually subsides, inadequate acute pain management can predispose patients to chronic pain, impairing their quality of life. multimodal opioid-sparing analgesia strategies are recommended, with recent advancements in ultrasound-guided regional anesthesia techniques showing promise in enhancing acute pain relief and reducing opioid consumption, particularly through truncal fascial plane blocks and parasternal blocks. however, the impact of these techniques on chronic postsurgical pain remains incompletely understood. this multicenter study aims to investigate the incidence of chronic postsurgical pain following cardiac surgery, exploring the influence of various factors and their implications on patients' quality of life.

Eligibility criteria:
inclusion criteria: * patients will be undergoing a first-time cardiac surgery involving a median sternotomy, including coronary artery bypass grafting (cabg) and all open-heart procedures, such as valvular repairs/replacement. * patients between the ages of 18-80 years * american society of anesthesiologists (asa) physical status score of ii-iii * patients will also sign the written informed consent form exclusion criteria: * patients scheduled for minimally invasive cardiac surgery, * patients with bmi\>40, * patients who undergone thoracotomy, * patients with alcohol and drug addiction, * patients with severe dysfunction in a significant organ (e.g., presence of severe hepatic and renal disease), * patients who undergone emergency and redo surgeries, * patients who cannot be extubated within the first 8 hours postoperatively, * patients have a severe psychiatric diseases such as psychosis or dementia that restrict cooperation with the patient (patients who cannot evaluate verbal numerical pain scales), * patients who are pregnant and breastfeeding, * patients who cannot be reached by phone during the postoperative follow-up periods * patients who cannot communicate in the native language.

Keywords: cardiac anesthesia chronic post-surgical pain nerve blocks
evaluation of leak-free bronchoscope adapter to limit ventilated air volume loss during bronchoscopy

Conditions: Pulmonary Disease

Summary: the purpose of this research is to evaluate the ability of a new bronchoscope adapter called "leak-free adapter" to limit the amount of air leaking out to the operating room (or) from the ventilator in intubated patients who undergo bronchoscopy.

bronchoscopy is a commonly performed procedure where a camera tipped device is used to look into a patient's lung. to perform bronchoscopy, a "standard commercial adapter" is connected to the ventilator tubing, which lets the doctors use the bronchoscope.the design of the "standard commercial adapter" can cause about 20% of air to escape from the ventilator to the or. this leaked air causes two issues: first, this can lead to lower oxygen levels and can limit the amount of time your physician can perform bronchoscopy. second, the leaked air can lead to the spread of harmful particles like anesthesia gas to the or. these particles can harm the staff in the operating room or spread to other patients in the hospital. this study will compare the benefit of the "standard commercial adapter" to the newly developed "leak-free adapter". the investigational procedure being studied here is repeating the bronchoscopy with the leak-free adapter. outcomes (which measure the benefit of the new adapter) will be measured for each adapter independently. bronchoscopy using both devices will be performed by the physician performing the procedure.

Eligibility criteria:
inclusion criteria: 1. participants who will be undergoing elective intubation for either a surgical or bronchoscopic procedure (diagnostic or therapeutic) 2. both males and females 3. adults 18 years and older exclusion criteria: 1. significant protocol deviation 2. significant non-compliance with protocol or study requirements 3. an adverse event which requires discontinuation which results in the inability to continue to comply with study procedures. 4. consent is withdrawn.

Keywords: bronchoscope adapter
the influence of breathing in writing

Conditions: Mouth Breathing

Summary: purpose: to examine whether nasal breathing influences the perception of sound causing trade between hard and soft consonants in the writing of children in school age and the incidence of trade.

to achieve the above goal explained, it was used: methods: the sample was consisted of 200 children, 100 previously diagnosed with oronasal breath (51 females and 49 males) who participated in the study group and 100 nasal breathers (54 females and 46 males) which were the control group. 36 words were dictated as minimal pairs to be written. then a story was submitted in sequence of six figures from which the subjects produced a text.

Eligibility criteria:
inclusion criteria: * mouth breather/nasal breather * literate exclusion criteria: * hearing trouble * speech trouble

Keywords: respiration learning speech language and hearing sciences
spinal cord injury program in exercise

Conditions: Spinal Cord Injuries

Summary: the purpose of this study is to examine two 8-week, remotely delivered exercise interventions: movement-to-music (m2m) and standard exercise training (set), with 327 adults with spinal cord injury. enrolled participants will be randomized into one of three groups: a) m2m, b) set, and c) attention control (ac).

the purpose of the spinal cord injury program in exercise (scipe) study is to examine two 8-week, remotely delivered exercise interventions: movement-to-music (m2m) and standard exercise training (set), with 327 adults with sci. the primary aim is to examine change in physical activity level after the 8-week m2m and set interventions. we hypothesize that participants in m2m and set will have significant increase in physical activity compared to an attention control (ac) group after the 8-week intervention. the secondary aim is to examine effects of the m2m and set interventions on health and quality of life outcomes. we hypothesize that participants in m2m and set will have significant increases in sleep quality and quality of life and decreases in pain and fatigue compared to ac after the 8-week intervention. exercise enjoyment in m2m and set participants will also be explored. the tertiary aim is to evaluate the demographic (age, race, sex), clinical (level of injury, type of injury), and psychosocial (social support, outcome expectations, self-efficacy, self-regulation) variables of two participant groups: 1) compliant participants who completed ≥ 50% of the intervention, and 2) noncompliant participants who completed post-testing but \< 50% of the intervention or who did not complete post-testing.

Eligibility criteria:
inclusion criteria: 1. diagnosed with a sci resulting in incomplete or complete (c5 and below) paraplegia or tetraplegia; 2. demonstrate readiness to physical activity by completing the physical activity readiness questionnaire for everyone (par-q+); 3. obtain medical clearance if required by par-q+; 4. converse in and read english. exclusion criteria: 1. no broadband internet access; 2. significant visual impairment that prevents seeing a computer screen to follow a home exercise program; 3. currently pregnant.
using continuous glucose monitoring to understand the glycemic impact of food

Conditions: Type 2 Diabetes; Currently Taking Metformin

Summary: this study will look at the impact that meals have on blood glucose (sugar) levels. subjects will be asked to use a continuous glucose monitoring system (cgm), which monitors glucose levels continuously. breakfast and lunch meals will be provided and must be consumed at the international diabetes center.


Eligibility criteria:
inclusion criteria: * female or male * age 18 and older * diagnosed with type 2 diabetes for a minimum of 6 months * is taking metformin for diabetes management; no other diabetes medications * has been on a stable dose of metformin for at least 3 months * hba1c is 7% or greater and less than 9%; \>7% or \<9% * bmi \<30kg/m2 * willing to give informed consent * no evidence of acute illness, fever, undue stress * motivated and capable of following the protocol and instructions provided by the healthcare professional * available for the study on the scheduled visit days * access to telephone communications exclusion criteria: * under 18 years of age * has not been diagnosed with type 2 diabetes for a minimum of 6 months * is currently taking other diabetes medications in addition to metformin * has taken other diabetes medications within the past 3 months * hba1c \ 9% * bmi \> 30kg/m2 * unable to follow the study protocol * no access to telephone communications * unable to read and write in english * unable to maintain their health, or have undue stress * skin abnormalities at the insertion sites that would confound assessment of the effect of the device on the skin * allergy to adhesives * any concomitant medical condition that would likely affect the evaluation of device performance * taken oral or inhaled prednisone or cortisone medications in the previous 30 days