ieem- work:rest cycles in burn survivors- humidity

Conditions: Hyperthermia; Burn Injury

Summary: the purpose of this project is to identify the effects of a severe burn injuries in humans on core temperature responses during work:rest cycles while in a heated environment.

non-burned control participants and participants who experienced serious burns covering ≥20% of their body surface area will be investigated. participants will undergo up to three work:rest cycles in the heat (via our environmental chamber) set to no higher than 40 °c. the work:rest cycle will comprise of 30 min of exercise that is followed by up to 20 min of rest, while staying in the heated conditions. three consecutive work:rest cycles will be performed as illustrated in the protocol document. during one visit, this protocol will be performed in a low humidity state. during the other visit (randomized and crossover), this protocol will be performed in a high humidity state.

Eligibility criteria:
inclusion criteria for non-burned individuals: * participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. participants must be between the ages of 18 and 65. exclusion criteria for non-burned individuals: * known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. participants may also be excluded if body mass index is ≥ 31 kg/m2 will likewise be excluded. participants must not have had a serious burn injury requiring more than 1 night stay in the hospital. inclusion criteria for individuals with up to 40% of their body surface area burned (moderate burn group): - participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. participants who have sustained a burn injury must have a burn covering 20-40% of their body surface area and 50% of those burns must be full-thickness burns requiring skin grafts. participants must be between the ages of 18 and 65. exclusion criteria for individuals with up to 40% of their body surface area burned (moderate burn group): - known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. participants may also be excluded if body mass index is ≥ 31 kg/m2 will likewise be excluded. inclusion criteria for individuals with greater than 40% of their body surface area burned (large burn group): - participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. participants who have sustained a burn injury must have a burn covering more than 40% of their body surface area and 50% of those burns must be full-thickness burns requiring skin grafts. participants must be between the ages of 18 and 65. exclusion criteria for individuals with greater than 40% of their body surface area burned (large burn group): - known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. participants may also be excluded if body mass index is ≥ 31 kg/m2 will likewise be excluded.

Keywords: burn survivor burn humid dry core temperature heat body temperature