Kornimate/medical-research-clean huggingface dataset:
the pain control in rib fracture with non-invasive stabilization (rct)

Conditions: Rib Fractures; Pain; Thorax; Fracture

Summary: brief summary: background: rib fractures are one of the most common causes of trauma disabilities and have become an important health issue. patients usually suffer from severe pain. a rapid and adequate pain control is considered as a priority to improve respiratory mechanics and reduce the risk of pulmonary and systemic complications. so far, there was no gold standard regarding pain control for rib fractures. objective: to assess the effect of the newly-designed prosthorax thoraxbelt in addition to oral analgesics on pain control of rib fractures method: there will be two groups of patients in this study. one group will be the patients with rib fractures who are necessary for in-hospital intense pain control. the other will consist of follow-up patients with rib fractures at an outpatient clinic. the investigators will aim to recruit 30 and 82 patients respectively.

the study has been approved by the hospital research ethics committee. arm1: the management and assessment of pain control in rib fracture with non-invasive stabilization: a randomized controlled trial (inpatients) arm2: the management and assessment of pain control in rib fracture with non-invasive stabilization: a randomized controlled trial (outpatients) primary outcome: 1. inpatient: visual analog scale (vas) for 6 hours, 12 hours and 24 hours after the surgery 2. outpatient: visual analog scale (vas) for the times at emergency room; 3 days, 3 weeks and 3 months after rib fracture at an outpatient clinic. secondary outcome: * inpatients 1. the accumulated dose of the inter-venous patient-controlled analgesic drug within 6 hours, 24 hours and 48 hours after the surgery 2. complication during the hospital stay 3. hospital stay 4. vas before discharge 5. unanticipated events (icu admission, a second surgery, death) 6. vas during the 1-week, 1-month and 3-month outpatient clinic visit after the surgery 7. an x-ray examination at an outpatient clinic 8. compliance on thoraxbelt after discharge * outpatients 1. complication during the follow-up period 2. unanticipated events (ward admission, icu admission, a surgery, ohca) 3. compliance on thoraxbelt after discharge 4. an x-ray examination at an outpatient clinic

Eligibility criteria:
inclusion criteria: * the adult patients with rib fractures (inpatients/outpatients) * the patients will be assessed to the further admission (inpatients) * the patients will be assessed to be at follow-up clinic visit (outpatients) exclusion criteria: * the accident of rib fractures has been occurred over 24 hours. (inpatients/outpatients) * refuse to be arranged to the admission (inpatients) * refuse to receive the ct scan (inpatients/outpatients) * chest wall infection or other diseases (inpatients/outpatients) * chest wall infected by rumors (inpatients/outpatients) * pregnancy (inpatients/outpatients) * further complications arise (inpatients/outpatients) * known allergy to thoraxbelt (inpatients/outpatients)

Keywords: rib fractures pain control posthorax thoraxbelt
integrative korean medicine treatment for pediatrics after traffic accident: retrospective chart review study and survey

Conditions: Pediatric ALL; Traffic Accident

Summary: a retrospective chart review study and survey research to verify the efficacy and safety of integrative korean medicine treatment for pediatric traffic accident patients.

this study is a long-term follow-up observational study targeting patients aged 0 to 6 years who visited any of the seven branches of jaseng hospital of korean medicine for outpatient and inpatient treatments after traffic accident injuries. after obtaining consent from the guardians, retrospective collection of medical records and computer data for traffic accident patients aged 0-6 will be conducted, followed by prospective surveys through google forms or phone interviews with the guardians. this data will be used for causal and factor analysis.

Eligibility criteria:
inclusion criteria: 1. patients aged 0 to 6 years who have visited the institution for symptoms caused by a traffic accident and have received at least one session of integrative korean medicine treatment as inpatient or outpatient care. 2. among the patients described in 1, those whose guardians understand the purpose and content of the research and consent to participate in the study. 3. among the patients described in 1, those whose guardians have the communicative ability, as well as the mental and physical capacity to respond appropriately to surveys. exclusion criteria: 1. cases where only consultation was provided or only western medical treatment was administered at our institution. 2. other cases deemed unsuitable for study participation by the researcher. 3. patients with a history related to the chief complaint.
effects of remote patient monitoring on heart failure management

Conditions: Heart Failure

Summary: the purpose of this randomized controlled trial is to determine the effects of a user-centric remote patient monitoring system on heart failure management. patients attending a heart failure clinic will monitor their weight, blood pressure, ecg, and symptoms at home. the hypothesis is that the remote monitoring system will improve heart failure outcomes through increased self-care and improved clinical management.

poor management of heart failure (hf) has added to the high costs and negative health outcomes from this chronic illness, including frequent hospitalization. hf patients require close monitoring to detect worsening health and to optimize their treatment. however, many patients visit their hf clinicians only once every few months, and perform minimal or no self-monitoring. remote patient monitoring is a potential tool to help clinicians and the patients better manage hf. a remote patient monitoring system (home monitoring of vital signs and symptoms) that has been developed with extensive clinician and patient input and testing, will be studied to determine its effects on hf management. half of one hundred patients from the university health network heart failure clinic will be randomly placed into the remote monitoring (rm) group and the other half will be in the control group. patients in the rm group will monitor their weight, blood pressure, ecg, and symptoms at home for 6 months. this information will be automatically sent from the medical devices wirelessly through bluetooth to a mobile phone, which will send the information to the data servers. both clinicians and patients will have access to the data. patients will get automated reminder telephone calls if they do not take the number of measurements prescribed by their doctors.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of heart failure (nyha class ii-iv) * out-patients attending the university health network heart failure clinic * english-speaking and able to read english * 18 years old or over exclusion criteria: * awaiting heart transplantation * not expected to survive over a year (as determined by their cardiologist) * unable to read text on a mobile phone due to vision disability * unable to self-care due to anxiety, depression, or decreased cognitive function * lack of manual dexterity to accurately press buttons on the mobile phone

Keywords: heart failure remote patient monitoring telemonitoring home monitoring randomized controlled trial self care
clinical investigation on the blood oxygenation at the optic nerve head in fabry patients

Conditions: Fabry Disease

Summary: this study aimed to evaluate blood oxygenation at the optic nerve head in relation with visual field losses observed in many fabry patients. data collected allowed to evaluate if there is a link between these two entities. study lasted 2 years during which a limited number of fabry patients had been compared to a control group to confirm any relationship between blood flow and field losses, and to see if these results varied over time. hypothesis 1. fabry patients will present significant differences in visual fields compared to control 2 there will be variability of the visual field defects on the long term but not on the short term 3 blood oxygenation will be higher for fabry patients 4 blood volume at the optic nerve head will be the same for both groups.

the first subjects who meet the following criteria will be enrolled in the study. inclusion criteria (fabry group ): * aged over 18 years old * being diagnosed with fabry disease * 3 subjects will be under enzyme replacement treatment for the treatment of fabry disease. * 3 subjects will not receive enzyme replacement treatment * is fit to give legal consent. * is available for a period of 2 years inclusion criteria (control group ): * matched for age and sex with group a - 6 participants * being healthy, with no known chronic systemic disease nor acute disease at the moment of the recruitment * is fit to give legal consent. * is available for a period of 2 years exclusion criteria (both groups): * presents with an active pathological ocular condition * presence of an abnormal optic nerve (congenital or acquired) * usage of topical ocular drug(s) at the time of selection * to have known allergy to topical diagnostic drugs used in this study * usage of systemic medication with known effect on the visual field

Eligibility criteria:
inclusion criteria: inclusion criteria (fabry group): * aged over 18 years old * being diagnosed with fabry disease * 3 subjects will be under enzyme replacement treatment for the treatment of fabry disease. * 3 subjects will not receive enzyme replacement treatment * is fit to give legal consent. * is available for a period of 2 years inclusion criteria (control group): * matched for age and sex with group a - 6 participants * being healthy, with no known chronic systemic disease nor acute disease at the moment of the recruitment * is fit to give legal consent. * is available for a period of 2 years exclusion criteria:( both groups): * presents with an active pathological ocular condition * presence of an abnormal optic nerve (congenital or acquired) * usage of topical ocular drug(s) at the time of selection * to have known allergy to topical diagnostic drugs used in this study * usage of systemic medication with known effect on the visual field

Keywords: visual field defect blood oxygenation optic nerve head
the efficacy of ap029 mix in patients with impaired carbohydrate metabolism

Conditions: Diabetes in Adolescence; PreDiabetes

Summary: the aim of the study is to demonstrate that a daily supplementation of ap029 mix: i) has a positive effect on reducing side effects of metformin, while enhancing the therapeutic effect of metformin; ii) normalizes prediabetes biomarkers in order to prevent further progression into diabetes.

randomized, double-blind, cross over study conducted under medical supervision on 1) group of 20 patients with type ii diabetes and 2) group of 10 patients with prediabetes. study design: 2 months of ap029 supplementation, 1 month wash-out, 2 months of placebo intake. patients will attend 4 visits. on each visit, the following parameters are analyzed: level of glucose, insulin, hba1c, hscrp lipid panel (total cholesterol (tc), triglycerides (tg), low density lipoprotein (ldl), hdl) and inflammatory and oxidative stress markers. in addition, a questionnaire of symptoms associated with metformin intake will be conducted

Eligibility criteria:
inclusion criteria for type ii diabetes: * women and men, 18-75 years old * patients diagnosed with type ii diabetes mellitus * patients on metformin treatment up to 5 months * bmi 20-35 kg/m2 * signed informed consent inclusion criteria for prediabetes: * women and men, 18-75 years old * bmi 20-35 kg/m2 * fasting blood glucose levels between 100 mg/dl and 125 mg/dl (5.6-6.9 mmol/l) * signed informed consent exclusion criteria for type ii diabetes: * patients diagnosed with type i diabetes * patients receiving insulin or other anti-diabetic medications * women who are pregnant, planning to become pregnant during the study, or breastfeeding * surgery within the last 6 months * intake of dietary supplements containing plant extracts rich in polyphenols and anthocyanins * intake of supplements containing: white mulberry, chromium, berberine * patients receiving glucocorticosteroids, immunosuppressants * oncological disease, autoimmune disease, severe liver dysfunction, tuberculosis, leukemia, multiple sclerosis, aids, rheumatoid arthritis, organ transplant * acute inflammation (c-reactive protein \>20mg/dl) exclusion criteria for prediabetes: * patients diagnosed with type i, ii, lada diabetes * patients receiving insulin or other anti-diabetic medications * women who are pregnant, planning to become pregnant during the study, or breastfeeding * surgery within the last 6 months * intake of dietary supplements containing plant extracts rich in polyphenols and anthocyanins * intake of supplements containing: white mulberry, chromium, berberine * patients receiving glucocorticosteroids, immunosuppressants * oncological disease, autoimmune disease, severe liver dysfunction, tuberculosis, leukemia, multiple sclerosis, aids, rheumatoid arthritis, organ transplant * acute inflammation (c-reactive protein \>20mg/dl)

Keywords: type ii diabetes prediabetes disorders of carbohydrate metabolism chokeberry elderberry
the effects of an acute bout of exercise on alcohol and cocaine craving - an fnirs study

Conditions: Substance Use Disorders

Summary: the study is a crossover randomised controlled trial. alcohol or cocaine dependent participants will be recruited from inpatient and outpatient psychiatric treatment centres, on the approval of their treating physician. a healthy control group will be recruited using online advertising. all participants will undergo each of three conditions in a randomised order; 1) 20 minutes of cycle ergometry at 50-60% of maximum heart rate; 2) 20 minutes of exercise at 70-80% of maximum heart rate; 3) 20 minutes of quiet reading. immediately before and after each condition, participants will be asked to complete a computerised stroop test, watch a film containing substance-related images, and self-report craving levels. during the stroop test and film viewing, participants' neural activity will be measured via functional near-infrared spectroscopy

the aim of this study is to examine whether, following acute exercise bouts at moderate and high intensities, reduced craving and increased inhibitory control can be observed in alcohol or cocaine dependent individuals. as the focus of this study is the potential of exercise to be integrated into treatment, individuals in treatment for their dependence, who have been abstinent for a short period, will be recruited.

Eligibility criteria:
inclusion criteria: for alcohol or cocaine dependent participants: * meeting three or more of the dsm-iv criteria for substance dependence (as determined by treating physician); * minimum of 20 days and maximum of 40 days abstinence from substance of dependence; * able to understand and complete the informed consent; * able to travel to study site independently, as confirmed by the treating psychiatrist; * assessed for physical and mental fitness by treating physician and cleared to take part in the study; * fewer than 3 hours of physical exercise or sport per week; for healthy controls: * fewer than 3 hours of physical exercise or sport per week; * no history of problematic alcohol or illicit drug consumption. exclusion criteria: * pregnancy * questionable findings during resting ecg screen
tcm health preservation for depression

Conditions: Depressive, Symptoms Depressive Disorder, Depression

Summary: this study aims to evaluate the feasibility and preliminary effects of traditional chinese medicine (tcm) health preservation for depression on depressive symptoms reduction and other health-related outcomes among hong kong chinese adults with depression. participants in intervention group will receive tcm health preservation course for six weeks (6 sessions, 2 hours each) and practice tcm health preservation during the 6-week follow-up period. participants in the control group (waitlist control) will receive usual care. after the follow-up assessment, tcm health preservation courses for depression will be provided to them for compensation.


Eligibility criteria:
inclusion criteria: * hong kong chinese adults aged 18-years-old to 65-years-old; * diagnosed with moderate level of depression (a score of 10\~20), evaluated by the patient health questionnaire-9 (phq-9); * can communicate in spoken cantonese and written chinese; * willing to provide written informed consent and be able to adhere to the study protocol. exclusion criteria: * being pregnant or during the lactation, or plan to get pregnant; * new onset or change of antidepressant medication or dosage in the last 3 months; * phq-9 score≥20, meaning a severe level of depression; * with a previous or present diagnosis of psychotic disorders as screened by the chinese version of the structured clinical interview for dsm-iv; * the score of hong kong montreal cognitive assessment less than 22; * significant suicidal risk as rated by the hamilton depression rating scale item on suicide (score ≥3); * with diagnosis of illness which can interfere the individuals to participate or adhere to the modified lifestyle; * with diagnosis of medical conditions, which are not suitable to modify diet or do physical activities recommended by physicians; * joining in another clinical trial during the study period; * with any major medical condition that causes depression based on the judgement of the investigator.

Keywords: depression traditional chinese medicine randomized controlled trial health preservation
study for the effectiveness of intensive therapy aiming at a remission of diabetic nephropathy

Conditions: Type 2 Diabetes Mellitus; Diabetic Nephropathy

Summary: study for the effectiveness of intensive therapy aiming at the remission of diabetic nephropathy

study for the effectiveness of intensive therapy for diabetic nephropathy in unblinded, randomized intergroup comparison study.

Eligibility criteria:
inclusion criteria: 1. patients with type 2 diabetes 2. urinary albumin-to-creatinine ratio: \>=300 mg/g creatinine twice in the first morning urine sample 3. serum creatinine level: =\<2.5 mg/dl 4. patients aged 20-75 years exclusion criteria: 1. type 1 diabetes 2. hereditary diabetes or secondary diabetes 3. non-diabetic nephropathy 4. familial hypercholesterolemia 5. secondary hypertension 6. unstable angina pectoris or history of myocardial infarction/stroke within 6 months prior to consent acquisition 7. malignant tumor or life threatening disease 8. history of angioedema 9. patients undergoing ldl apheresis 10. biliary system obstruction or severe liver injury 11. liver dysfunction 12. allergy for ace-is, arbs or hmg-coa reductase inhibitors 13. pregnant or nursing patients 14. others: patients who are not suitable for this trial

Keywords: diabetes nephropathy
hepatic enzymes, psychological measures, and sexual dysfunction responses to aerobic exercise in hepatitis-c men

Conditions: Hepatitis C; Erectile Dysfunction

Summary: chronic hepatitis c virus (hcv) infection is a systematic disease that affects several aspects of patients' well-being, including physical, mental, social, and sexual quality of life. in recent years, this clinical trial aims to search the response of hepatic enzymes, psychological measures, and sexual dysfunction to aerobic exercise in hepatitis men with sexual dysfunction complaint

hepatitis men with sexual dysfunction (erectile dysfunction) complaint (n=46) will be randomized randomly to 23-men exercise-training (one hour walking on treadmill, for 3 months, three walking sessions per the week) hepatitis-c group or 23-men waiting-hepatitis-c group.

Eligibility criteria:
inclusion criteria: * men with hepatitis c men diagnosis * men with sexual dysfunction (erectile dysfunction) exclusion criteria: * obesity , men with cardiac/thoracic/systemic diseases, drugs for sexual dysfunction (erectile dysfunction)
vascular physician offer and report (vapor) trial

Conditions: Peripheral Artery Disease (PAD)

Summary: the purpose of the study is to see if vascular physicians (your provider) using a combination of proven smoking cessation tools in an organized way can help vascular patients quit smoking better than usual. the doctors where you are being treated have been chosen to either provide: the combination therapy of giving you advice, considering prescribing medications to help you quit smoking, and referring you to a phone quitline, or to continue their usual smoking cessation practices (which may include all, some, or none of the treatments above).


Eligibility criteria:
inclusion criteria: * age \>18 * current smoker * plan to have a vascular quality initiative (vqi) procedure in \> 7 days exclusion criteria: * pregnant women, fetuses and neonates * children * people with impaired decision-making capacity

Keywords: vapor smoking cessation pad
a clinical study of the acrysof® iq extended depth of focus intraocular lens (iol)

Conditions: Cataract

Summary: the purpose of the study is to demonstrate the safety and performance of acrysof iq extended depth of focus (edf) intraocular lens (iol) at month 6. depth of focus (dof) is the amount of focal plane displacement behind a lens that does not degrade the image quality of a distant object. a larger dof allows sharp images of closer objects and may provide improved vision at intermediate and near distances.

both eyes of a subject must require cataract surgery to qualify for enrollment into this study. subjects participating in the trial will attend a total of 9 scheduled study visits over a 7-8 month period. of the 9 visits, 1 is preoperative, 2 are operative, and the remaining 6 are postoperative visits. primary endpoint data will be collected at the month 6 (day 120-180) post second eye implantation visit.

Eligibility criteria:
inclusion criteria: * best corrected distance visual acuity (bcdva) of 0.3 logarithm of the minimum angle of resolution (logmar) (20/40 snellen) or worse either with or without a glare source present (e.g., brightness acuity tester) * preoperative regular astigmatism of \< 1.0 d in both eyes * clear intraocular media other than cataract * diagnosed with cataract in both eyes * planned cataract removal by routine small incision surgery * calculated lens power between 18.0 and 25.0 diopter (d) \[when targeted for emmetropia (0.0 d)\] * willing and able to complete all required postoperative visits * able to comprehend and sign an ethics committee-approved statement of informed consent * potential postoperative bcdva of 0.2 logmar (20/32 snellen) or better in each eye based on investigator's medical opinion. exclusion criteria: * history of eye pathology and/or inflammation, as specified in the protocol * clinically significant/severe ocular surface disease that would affect study measurements based on investigator expert medical opinion * history of previous intraocular or corneal surgery * pregnant/lactating or has another condition with associated fluctuation of hormones that could lead to refractive changes * taking systemic medications that in the investigator's best medical judgment may confound the outcome or increase the risk to the subject.