Kornimate/medical-research-clean huggingface dataset:
16-week efficacy and 3-year safety, tolerability and efficacy of secukinumab in active ankylosing spondylitis patients

Conditions: Spondylitis, Ankylosing

Summary: the purpose of this study was to generate 16-week efficacy data, as well as up to 3-year efficacy, safety and tolerability data in subjects with active as despite current or previous nsaid, dmard and/or anti-tnf therapy.


Eligibility criteria:
inclusion criteria: moderate to severe as, prior radiographic evidence according to the modified ny criteria (1984), inadequate response to nsaids. -- exclusion criteria: pregnancy or lactation, on-going infectious or malignant process on a chest x-ray or mri, previous exposure to il-17 or il-17r targeting therapies, previous exposure to any biological immunomodulating agent excluding tnf antagonists, previous cell depleting therapy.

Keywords: ain457, ankylosing spondylitis, chronic inflammatory disease, inflammatory back pain, secukinumab, self-injection
efficacy and safety of tamsulosin for children with posterior urethral valve.

Conditions: Posterior Urethral Valve

Summary: to determine whether there is a role for tamsulosin, a selective alpha-1 adrenergic blocker, as therapy in children with posterior urethral valve post valve ablation , and whether there are side effects involved.

we aim to evaluate the safety and efficacy of alpha adrenergic blocker, tamsulosin, in children with posterior urethral valves regarding: * effect on upper urinary tract (hydronephrosis improvement, vesicoureteric reflux resolution and renal function) * effect on bladder outlet resistance * effect on intravesical detrusor pressure * febrile urinary tract infection recurrence

Eligibility criteria:
inclusion criteria: * children with a diagnosis of puv. exclusion criteria: 1. patients with other conditions that can potentially affect lower or upper urinary tract functions (e.g. spinal dysraphism, anorectal malformation and prune belly syndrome) 2. patients who were treated with urinary diversion as vesicostomy or cutaneous ureterostomy. 3. patients who had primary treatment of puv ablation at other hospitals. 4. contraindications to α blocker treatment. 5. patients who refuse to participate in the study

Keywords: posterior urethral valve
rotational stability of the acrysof® toric

Conditions: Cataract

Summary: to assess the rotational stability and the residual refractive cylinder and patient reported outcomes of the acrysof toric intraocular lens after unilateral or bilateral implantation.


Eligibility criteria:
inclusion criteria: * monolateral or bilateral cataracts * anticipated intraocular lens (iol) power of +10 diopters (d) \~ +25d * 0.75 \~ 2.0 d of astigmatism measured preoperatively by keratometry readings * able to sign the informed consent, to comply with scheduled visits and other study procedures exclusion criteria: * preoperative ocular pathology * previous intraocular or corneal surgery * an increased risk for complications which could require vitreoretinal surgery * corneal irregularities * corneal opacities * current contact lens usage * uncontrolled diabetes

Keywords: cataract
low implanted second trimester placenta and placenta previa

Conditions: Placenta Previa

Summary: placenta previa is defined as a placenta implanted in the lower segment of the uterus, presenting ahead of the leading pole of the fetus (over or near the internal os). the prevalence of placenta previa has been estimated to be approximately 0.5% of all pregnancies, and this increase correlates to the elevated cesarean section rate . in egypt, the prevalence of placenta previa is around 1.3% in sohag governorate and 1.5% in aswan region according to. although various studies have tried to address risk factors associated with placenta previa development, the etiology of placenta previa still remains obscure. several risk actors have been identified as strong contributors to placenta previa development. it is also a significant contributor to severe postpartum hemorrhage.risk factors include; history of previous cesarean section, advanced maternal age, history of previous abortions, high parity and substance abuse during pregnancy (cigarette smoking), placental size (multiple pregnancy), endometrial damage (previous dilatation and curettage), uterine scars and pathology (previous myomectomy or endometritis), placental pathology (marginal cord insertions and succenturiate lobes), previous placental previa, and curiously.


Eligibility criteria:
inclusion criteria: 1. pregnant women between 18-24 weeks. 2. diagnosed to have low implanted placenta by ultrasound exclusion criteria: 1. patient refused to follow-up in our setting. 2. patient refused to perform trans-vaginal ultrasound in the second trimester of gestation.
efficacy and safety of the self-expanding intracranial stent (tonbridge) for endovascular treatment of intracranial aneurysms

Conditions: Intracranial Aneurysm

Summary: the purpose of this study is to assess the efficacy and safety of self-expanding intracranial stent (tonbridge), by comparing the data obtained from self-expanding intracranial stent (zhuhai tonbridge medical tech. co., ltd.) and lvis/lvis jr. (microvention europe sarl) for endovascular treatment of intracranial aneurysms.

this is a prospective, multi-center, randomized, open, parallel positive controlled, non-inferiority trial. this clinical trial is conducted at more than 2 centers in china, and patients who intend to be treated with stent-assisted coiling for intracranial aneurysms are enrolled. eligible patients are randomized into experimental group using self-expanding intracranial stent (tonbridge) or control group using lvis and lvis jr. (microvention) in a 1:1 ratio. the purpose of this study is to evaluate the effectiveness and safety of the self-expanding intracranial stent (tonbridge).

Eligibility criteria:
inclusion criteria: * age 18 to 80 years, any gender; * diagnosed as intracranial aneurysm and the subject is assessed as suitable for stent-assisted coiling; * subject or guardian is able to understand the purpose of study, shows sufficient compliance with the study protocol and provides a signed informed consent form. exclusion criteria: * aneurysm rupture within 30 days before enrollment; * diagnosed as blood blister-like aneurysm, pseudoaneurysm, infected aneurysm, or aneurysm related to arteriovenous malformations; * conditions that are not appropriate for stent delivery and deployment judged by investigators (severe stenosis of parent artery, severe tortuosity of parent artery, stent failing to reach the lesion, stent in the target lesion of parent artery, etc.); * modified rankin scale (mrs) score ≥3; * heart, lung, liver and renal failure or other severe diseases (intracranial tumor, systemic infection, disseminated intravascular coagulation, myocardial infarction within 12 months before enrollment, history of severe psychosis, severe stenosis or occlusion of cerebral feeding artery, etc.); * major surgery within 30 days before enrollment； * known coagulation dysfunction or contraindication to anticoagulant and antiplatelet therapy; * known allergy to nickel-titanium alloy metal materials; * life expectancy \<12 months; * pregnant or breastfeeding women; * subject has participated in other drug or medical device clinical trials within 1 month before signing informed consent; * other conditions judged by the investigators as unsuitable for enrollment.
photogrammetry analysis in the assessment of work-related musculoskeletal disorders risk among physical therapists

Conditions: Musculoskeletal Disorder

Summary: this study will be conducted to investigate the risk of work-related musculoskeletal disorders due to the postural load among physical therapists

musculoskeletal disorders (msds)refer to an array of signs and symptoms involving various areas of the musculoskeletal system. the clinical manifestations of msds include pain, swelling/redness, stiffness, and weakness or loss of function. such manifestations affect the muscles, joints, tendons, nerves, and supporting structures in various body parts. work-related musculoskeletal disorders (wmsds) have a high significant occupation problem worldwide. one-third of all injuries in a day occurs due to occupational hazards are wmsds reports the bureau of labor statistics.previous works have shown that parameters such as the environment , the level of experience , the country of origin ,the institution in which the professional evolves had an influence on the level of risk of wmsd prevalence. many studies have addressed the issue of wmsd in ppts. the prevalence of msds by body area is the most commonly used analysis . the results showed that the areas most at risk for msds are the neck, lower back and upper extremities. however, the studies reported different results. indeed, the prevalence vary between 5.3 % and 61 % , between 14.3 % and 62 % and 8 % and 83 % respectively for the neck, low back and thumb. these differences in prevalence have also been observed in other areas such as the shoulder or lower extremity . studies have focused on risk factors responsible for the occurrence of msd or which reinforce the associated symptoms. two hundreds supjects will be conducted to this study

Eligibility criteria:
inclusion criteria: * males and females egyptian physical therapists at al kasr elaini hospital and at the outpatient clinics of the faculty of physical therapy, cairo university, and badr university, will be included in the study. * age ranges from 21-30 years old of physical therapists and their bmi is between 18 and 24.9. * 4 hours of work daily at least * no working experience to 2 years of experience only exclusion criteria: * congenital musculoskeletal disorders * fractures * previous musculoskeletal surgery * cardiovascular disease * pulmonary disease * diabetes * neurological disease

Keywords: photogrammetry analysis physical therapist musculoskeletal disorder
application of intraoperative transesophageal echocardiography imaging of vein and clcvp in early prediction and intervention csa-aki

Conditions: Acute Kidney Injury

Summary: the goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. the main questions it aims to answer are: * intraoperative transesophageal ultrasound doppler venous imaging can be used to predict the occurrence of cardiac surgery associated acute kidney injury (csa-aki ) in the early stage by observing the changes of renal vein, portal vein and hepatic vein blood flow patterns, calculating the renal vein stasis index and portal vein pulsatility index, and evaluating the degree of venous congestion. * controlled low central venous pressure (clcvp) technology can reduce the occurrence of csa-aki by reducing venous congestion and increasing renal perfusion pressure. participants will receive transesophageal ultrasound doppler during cardiac surgery. if the participant is assigned to the intervention group, if the central venous pressure of the participant is ≥ 10mmhg 30 minutes after the end of cardiopulmonary bypass, he will receive nitroglycerin pumped to apply the controlled low central venous pressure (clcvp) technology; if participants are assigned to the control group, no intervention measures will be taken. the researchers will compare the intervention group with the control group to see the occurrence of aki and akd after cardiac surgery.


Eligibility criteria:
inclusion criteria: patients aged above 18 years undergoing coronary artery bypass graft or heart valve surgery under cardiopulmonary bypass. exclusion criteria: 1. patients with ckd history, end-stage renal disease and renal transplantation before operation 2. used nephrotoxic drugs within two weeks before operation 3. known renal artery stenosis and renal malformations 4. there are contraindications for transesophageal ultrasound doppler evaluation of esophageal space occupying lesions

Keywords: acute kidney injury acute kidney disease postoperative complications of cardiac surgery transesophageal echocardiography
a phase ii study of fruquintinib in combination with gefitinib in patients with advanced non-small cell lung cancer

Conditions: NSCLC

Summary: fruquintinib in combination with gefitinib as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harboring activating egfr mutations : a single-arm, multicenter, phase ii study

this phase ii trial will evaluate the combination of fruquintinib and gefitinib in advanced nsclc. the endpoint will be to evaluate the efficacy and safety of the combination.

Eligibility criteria:
inclusion criteria: * signed informed consent form. * age between 18 to 75 years old. * histologically or cytological documented stage iiib/iv non-squamous non-small cell lung cancer patients who have never received systematic treatment for the late-stage disease. * ecog 0-1 * patients must have measurable lesions exclusion criteria: * prior systematic treatment for the advanced nsclc * absolute neutrophil count (anc) \< 1.5×10\^9 /l, or platelet count \< 100 ×10\^9/l, or hemoglobin \< 9 g/dl * total bilirubin \> 1 uln; sgot (ast), sgpt (alt), \> 1.5 uln; for patient with liver metastasis，ast or alt \> 3 uln * known hiv positive * hypersensitivity to either of the investigation drugs

Keywords: fruquintinib nsclc 1st line
exercise in men receiving radiation therapy for prostate cancer.

Conditions: Prostatic Neoplasms

Summary: androgen deprivation therapy is a commonly used treatment for men with prostate cancer. unfortunately this can lead to functional decline, fatigue, increased body fatness, loss of lean body tissue and impaired qol. previous research has demonstrated the exercise can may reduce fatigue and improve qol in men on adt. this study will evaluate whether aerobic versus resistance exercise over a 24 week period of training will reduce morbidity and improve qol in men receiving radiation plus or minus adt with curative intent

a total of 220 men with a diagnosis of prostate cancer, scheduled to receive radiation will be recruited. the study is a parallel 3-group design with groups stratified for intended duration of adt ( greater or less than 12 weeks) and random assignment to aerobic, resistance or wait list control groups. the dependent variable of interest will fatigue measured at 24 weeks by the 13 item fact-fatigue. dependent variables of secondary interest will be toxicity of radiation, body composition, muscular fitness, cardio-respiratory fitness, metabolic fitness, and prostate specific qol. all exercise sessions will be performed 3 times per week at the ottawa hospital regional cancer center

Eligibility criteria:
inclusion criteria: * prostate cancer * radiation therapy with curative intent * adt exclusion criteria: * contraindication to exercise * uncontrolled hypertension * uncontrolled cardiac disease * uncontrolled psychotic condition * unable to obtain informed consent
a study of the safety and effectiveness of hydroxyurea in patients on potent antiretroviral therapy and who have less than 200 copies/ml of hiv rna in their blood

Conditions: HIV Infections

Summary: this study compares the safety and effectiveness of continuing your current anti-hiv medications to that of adding or switching some of your anti-hiv medications. it will follow the effect of these medication changes, including the addition of hydroxyurea (hu), on long-term viral suppression. other medications which may be added include didanosine (ddi) and/or stavudine (d4t). patients receiving combination antiretroviral therapy with indinavir (idv), zidovudine (zdv)(or d4t) and lamivudine (3tc) show viral suppression for two years or more. discontinuation of one or two of these drugs results in prompt loss of the viral suppression. other studies show that addition of hu to some reverse transcriptase inhibitor treatments results in increased antiviral effects. this study will provide further information on the effect of adding hu to a treatment regimen with respect to long-term viral suppression.

previous actg studies show that discontinuation of one or two of a three-drug regimen (idv, zdv, 3tc) leads to prompt loss of viral suppression in the plasma. in this trial, it will be determined whether adding hydroxyurea (hu) to a suppressive regimen increases long term viral suppression. important safety information on the tolerance of hu regimen will be characterized in asymptomatic patients with viral suppression. patients are equally randomized to one of three arms and receive treatment as follows:arm a: idv plus ddi plus d4t plus hu placebo. arm b: idv plus ddi plus d4t plus hu. arm c: idv plus 3tc/zdv (or d4t plus 3tc). patients are monitored every 8 weeks with plasma hiv rna levels and cd4 cell counts.

Eligibility criteria:
inclusion criteria you may be eligible for this study if you: * are 13 years or older. * have documented hiv-1 infection. * are currently receiving combined idv, zdv(or d4t), and 3tc for at least 6 consecutive months, resulting in hiv rna less than 200 copies/ml and cd4 cell count greater than 200 cells/mm3. * had a cd4 count greater than 100 cells/mm3 before starting current anti-hiv therapy. * are of childbearing age and agree to practice abstinence or use of combined barrier and hormonal methods of birth control during and for 3 months after the study. exclusion criteria you will not be eligible for this study if you: * have taken various medications and have various laboratory results (see technical abstract). * have cancer requiring chemotherapy. * have an unexplained fever for 7 days or diarrhea for 15 days in the month before the start of the study. * had prior peripheral neuropathy or hepatitis. * recently underwent radiation, experimental, or infection therapy. * are pregnant or breastfeeding.

Keywords: drug therapy, combination hiv protease inhibitors hydroxyurea reverse transcriptase inhibitors anti-hiv agents viral load
motor imagery and motor execution based bci in stroke

Conditions: Stroke; Neurorehabilitation; Motor Imagery; Motor Execution; Brain-computer Interface

Summary: about 50% of stroke patients are unable to live independently because of residual disability. brain-computer interface (bci) is based on closed-loop theory, which facilitates neurological remodeling by establishing a bridge between central and peripheral connections. studies have confirmed that bci real-time neurofeedback training system based on motor imagery alone can effectively improve patients' motor function. so, is the benefit greater if motor imagery is combined with motor execution? current conclusions are mixed. in addition, previous studies and our preliminary study found that prefrontal fp1 and fp2 areas play an important role in motor recovery after stroke, and they are involved in motor imagery, motor execution, attention and other behavioral processes. therefore, we designed a bci training system based on motor imagery and motor execution with prefrontal electroencephalogram (eeg) signals as the modulatory target. this was a randomized placebo-controlled double-blinded clinical trial. patients in the test group performed bci-controlled upper extremity motor imagery + upper extremity pedaling training. the control group had the same equipment and training scenario, and patients were also asked to imagine the upper extremity pedaling movement with effort, and patients also wore eeg caps, but the eeg signals were only recorded without controlling the pedaling equipment. after 3 weeks of treatment, we observed the changes of motor and cognitive functions as well as fnirs-related brain network characteristics in both groups.


Eligibility criteria:
inclusion criteria: * aged 35-79 years old; * patients with first ischemic stroke onset from 2 week to 3 months; * hemiplegia with upper limb strength grades 1-3; * consciousness, sitting balance level 1 or above, can cooperate with assessment and treatment; * the patient or its authorized agent signs the informed consent form. exclusion criteria: * severely impaired cognition (mmse\<20), unable to pay attention to and understand screen information; * severe pain, spasticity and limited mobility of upper extremity.
incidence and management of ocular hypertension following deep anterior lamellar keratoplasty

Conditions: Unrecognized Condition

Summary: this is a retrospective case series study that included patients who performed deep anterior lamellar keratoplasty and presented with elevated intraocular pressure during follow up.

this is a retrospective case series study that included patients who performed deep anterior lamellar keratoplasty and presented with elevated intraocular pressure during follow up. patients' demographic characteristics, medical, and ocular history will be recorded. inclusion criteria will include patients who were diagnosed with elevated intraocular pressure (iop) after dalk surgery performed from 2018 to 2020 with follow up duration more than 6 months. patients with less than 6 months of follow-up will be excluded from the study. patients' demographic characteristics, medical and ocular history will be recorded. baseline complete ophthalmic examination was performed. it included best corrected visual acuity (bcva) using landolt c chart that was converted to log minimum angle of resolution (log mar) for statistical analysis, slit lamp anterior segment examination (with attention to cornea, bulbar conjunctiva and ac), intraocular pressure measurement using rebound system (i care tonometer, topcon, canada), angle assessment and fundus examination using goldman 3 mirror contact lens. high iop was defined as intraocular pressure more than 25 mmhg. data will be collected with attention to appropriate management done either medical treatment or surgical intervention.

Eligibility criteria:
inclusion criteria: * patients who were diagnosed with elevated iop after dalk surgery performed from 2018 to 2020 exclusion criteria: * patients with penetrating keratoplasty
calf muscle atrophy after achilles tendon rupture. a clinical-radiological-biomechanical multicenter study.

Conditions: Achilles Tendon Ruptures

Summary: multicenter achilles tendon study switzerland. comparing three mainstream treatment types: open, percutaneous and conservative (non-operative) treatments. comparing force torque measurements, muscle volume and clinical scores.


Eligibility criteria:
inclusion criteria: * 20-65 years of age, * a healthy, contralateral leg * physiological, clinically determined alignment of the knee, foot and ankle * no trauma to the healthy leg * no neuromuscular impairments including muscle dystrophies * no other posttraumatic injuries or osteoarthritis of the knee, foot or ankle of the affected leg. exclusion criteria: * re-rupture or reoperation of the achilles tendon * surgical site infection * neuromuscular diseases including muscle dystrophies * ankle valgus of more than 15° or ankle varus of more than 5° * other known pathologies of the non-affected leg * general mri exclusion criteria (e.g. pacemaker, other metal not qualifying for an mri, tattoos and claustrophobia) * body mass index (bmi) of \> 40 kg/m2

Keywords: achilles tendon, muscle volume, achilles tendon length, force, atrs, hannover, aofas
the influence of different factors on workers' disability due to low back pain

Conditions: Low Back Pain

Summary: the purpose of this study is to determine, in spanish workers, the influence of different factors (personal, psychological, work related and clinical) on the risk of being on sick leave during the 18 months after baseline assessment, and on the duration of that sick leave.


Eligibility criteria:
inclusion criteria: * subjects who get their checkups at participating health services * with a labor contract that won't make it likely that they stop work before the next 18 months, for causes other than their health * who sign the informed consent form exclusion criteria: * don't sign the informed consent form * inability to fill our the questionnaires * bedridden * rheumatologic inflammatory disease, cancer or fibromyalgia * suspicion of fibromyalgia * red flags for systemic disease * criteria for surgery * criteria for urgent referral to surgery

Keywords: low back pain workers disability sick leave