Kornimate/medical-research-clean huggingface dataset:
health through activity: a pilot study of a rehabilitation intervention for people living with multiple myeloma

Conditions: Multiple Myeloma

Summary: the purpose of this study is to explore whether a structured program can help reduce the challenges of decreased physical functioning and quality of life for participants with multiple myeloma by providing a customized exercise program and fostering engagement in meaningful activities. the name of the study intervention involved in this study is: health through activity (hta) (six-session, rehabilitation exercise regimen)

the goal of this single arm, pilot study of the health through activity (hta) rehabilitation intervention for people living with multiple myeloma is to determine if investigators can feasibly deliver the program out of the impact practice center at the mgh institute for health professions. - the six-session 'health through activity' program provides a customized exercise plan and encourages engagement in activities to reduce disability and improve quality of life. * study procedures including screening for eligibility, in-clinic visits, questionnaires, and surveys. * participation in this research study is expected to last up to 4 months. it is expected that up to 20 people will take part in this research study. an internal grant from the massachusetts general hospital institute of health professions is providing equipment and staffing for this study.

Eligibility criteria:
inclusion criteria: -≥18 years of age * diagnosed with multiple myeloma currently receiving maintenance therapy, * experiencing disability as indicated by an answer of "yes" to the question "do health problems interfere with your ability to carry out your social or day to day activities?" exclusion criteria: * bone pain that is either a) new onset or increased in the past month or b) uncontrolled i.e., in the patient's estimation the bone pain "greatly interferes with daily activities" * history of fracture in the past 12 months without fixation, or * any injury or medical condition that would prohibit being able to safely perform exercise as indicated by the physical activity readiness questionnaire\[29\] (i.e., atrial fibrillation, chest pain or angina, uncontrolled high blood pressure or hypertension, loss of balance due to dizziness in the past 12 months, or loss of consciousness in the past 12 months). * we will also exclude individuals with moderate or worse cognitive impairment as indicated by a score of 3 or less on the callahan six item cognitive screening tool.

Keywords: multiple myeloma physical therapy exercise program
comparison of adhesive latch device to subcuticular skin closure at the time of cesarean section

Conditions: Wound

Summary: the objective of this study was to compare the an adhesive latch device (" dermaclip") to subcuticular skin closure at the time of cesarean section. currently, no studies exist comparing these two closure techniques. the hypothesis is dermaclip closure is faster than subcuticular closure. the null hypothesis is there is no difference in closure times. there is a study (see reference at bottom) that compares staples closure to subcuticular closure, but none comparing subcuticular to dermaclip closure. dermaclip device is easily deployed and is expected to be as fast as staples closure compared to subcuticular as noted in the prior study referenced below.


Eligibility criteria:
inclusion criteria: 1. age greater than 18 2. elective cesarean section 3. term pregnancy exclusion criteria: 1. fever \>101f in the past 14 days 2. antibiotics in the past 14 days 3. suspected ongoing infection 4. poorly controlled gestational diabetes 5. allergic to adhesive

Keywords: dermaclip subcuticular cesarean section staples adhesive latch rousseau
effect of inhibitory kinesio-tape of the upper trapezius on lower trapezius muscle excitation

Conditions: Scapular Dyskinesis

Summary: shoulder pain increases excitation (or activity) of the upper trapezius (ut) and reduces excitation in lower trapezius (lt). despite inconclusive evidence, kinesio-tape (kt) is often used to modify muscular excitation within the ut and/or lt to help correct alterations in scapular position and motion associated with shoulder pain/injury. the objectives of the current study were to determine if: 1) inhibitory kt to the ut acutely increases muscle excitation (whole-muscle and spatial distribution) within the lt in healthy individuals; and 2) if loading the limb alters the magnitude of change in muscle excitation of the lt. we hypothesize that: 1) inhibitory kt application to the ut will immediately increase whole-muscle lt excitation, and result in an inferior shift in the distribution of excitation within the lt compared to no tape and sham-kt tape conditions; and 2) the magnitude of immediate increase in lt excitation with kt would be greater in the loaded condition. a repeated-measures, crossover design was used to determine the impact of kt applied to ut and load on muscle excitation of the lt. participants were asked to perform a repeated arm elevation task during three different taping conditions: no kt, experimental kt and sham kt. each taping condition performed the repeated arm elevation task during two loading conditions: no load and loaded with 2.3 kilograms. all six conditions were tested during one visit with the no load condition preceding the loaded condition for each taping condition. a baseline trial (no kt; n-kt) was performed first, followed by both an experimental-kt (e-kt) and sham-kt (s-kt) condition. the order of the e-kt and s-kt conditions were randomized and the order was counterbalanced. testing for each tape condition lasted approximately 10-minutes for a total of 45-minutes per participant including screening, emg set-up and clean-up. kt was applied to the ut and muscle excitation (emg amplitude) was measured in the lt using one single 32-grid high-density surface electromyography (hd-semg) electrode during a repeated arm elevation task.


Eligibility criteria:
inclusion criteria: * right-handed individuals * no current shoulder pain or pathology in the shoulder, neck, back. exclusion criteria: * recent history (\<6 months) of injury or orthopedic disorder of the shoulder, upper back or neck (e.g. rotator cuff tears, disc pathologies, etc.) * neurological or musculoskeletal disorder (e.g. epilepsy, multiple sclerosis, etc.) * current pain in the shoulder, upper back or neck * previous allergies or skin irritation to adhesives.

Keywords: kinesio tape (kt) shoulder upper trapezius lower trapezius
action observation therapy versus mirror therapy on upper limb in stroke

Conditions: Stroke

Summary: stroke is a medical condition which causes the cessation of blood flow to the brain cells and results in cell death and ultimately can lead to motor disorders, perception disorders, language disorders, sensory disturbances.it is well known that stroke is the leading cause of death and one of the greatest causes of long-term motor disability in adults.the incidence of stroke is increasing day by day in low-income countries as compared to high-income countries because of the effects of not using evidence-based practice in health-related conditions in low-income countries. in the last few years, several approaches have been used for the recovery of hand dexterity after stroke. among them, the mirror therapy, task-oriented therapy, robot-assisted rehabilitation and action observation has gained greatest attention.action observation training is one of the new developing rehabilitation technique that targets motor learning by the activation of mirror neurons and is the most important approach that targets the motor and functional recovery in stroke patients. in action observation training, the movements are produced because of the external stimuli in which actually the visual attention recruit the cerebellar-thalamic-cortical circuit of the brain. action observation is based on activities of the motor neuron system and they discharge mostly in association with complex tasks as compared to simple tasks.


Eligibility criteria:
inclusion criteria: * both male and female * middle cerebral artery stroke * 1 to 6 months of stroke onset * baseline score of the fugyl myer assessment is between 20 and 60 for the upper limb. * modified ashworth scale with a score of 2 ability to follow the study instructions-mini mental state examination (mmse) score \>25 exclusion criteria: * participants failing to fall in this category would be excluded from the study. * patients who cannot perform the active movement of the upper limb in pre-stroke condition due to musculoskeletal problems * cardiopulmonary diseases which could hinder their ability to participate in the rehabilitation program in this study * patient with impaired cognition
optimization of osteoporosis management among patients older than 45 years old with low energy fracture.

Conditions: Osteoporosis, Management Care, Fracture

Summary: harrington's metaphorical depiction captures the essence of the problem : "osteoporosis care of fracture patients has been characterized as the bermuda triangle made up of orthopaedists, primary care physicians and osteoporosis experts into which the fracture patient disappears". the most effective way to achieve this goal is through implementation of coordinator-based post fracture models of care. exemplar models have been refered to as "fracture liaison service" (united-kingdom \[1-3\], europe \[4,5\] and australia \[6-8\]) "osteoporosis coordinator program" (canada \[9,10\]) or "care manager programs" (usa \[11,12\]). the objective of this trial is to assess efficacy of a new coordinator-based post-fracture program in the saint-joseph hospital in paris to improve the management of osteoporosis after fracture thanks to an optimal recommendations practice to reduce the incidence of secondary fractures. men and women are included aged over 45 years with fragility wrist and hip fractures. evaluation criteria are based on the evidence-based assessment (stratify risk, identify secondary causes of osteoporosis, fracture evaluation), the medication adherence, others prescriptions adherence (osteodensitometry), the incidence of secondary fractures and number of falls. number of patients : 200 duration of the study: 3 years patients' participation duration: 6 months


Eligibility criteria:
inclusion criteria: * men and women over 45 years * fragility wrist and hip fractures * volunteer exclusion criteria: * public route accident * emergency illness associated * short life expectancy * not volunteer * bedridden patient
community mobilization for improved clean cookstove uptake, household air pollution reduction, and hypertension prevention

Conditions: Hypertension

Summary: using a focused implementation research framework, the epis (exploration, preparation, implementation and sustainment) model in a type-2 hybrid design, the study will be conducted in 3 phases: 1) a pre-implementation phase that will use the exploration and preparation domains of epis to: a) explore barriers and facilitators of clean fuel- clean- stove (cf-cs) use, and b) develop a culturally-tailored cm strategy for cf-cs use; 2) an implementation phase that will use the implementation domain of epis to compare in a cluster rct of 32 peri-urban communities (640 households), the effect of cm vs. a self-directed condition (i.e. receipt of information on cf-cs use without cm) on adoption of cf-cs use; and systolic bp reduction; 3) a post-implementation phase that will use the sustainment domain of epis to evaluate the effect of cm strategy vs. self-directed condition on sustainability of the cf-cs use in 640 households across the randomly assigned 32 peri-urban communities in nigeria. the lagos state university college of medicine (lasucom) working with the moh will oversee research coordination in nigeria.

this study will use cm to engage in the community dialogues, organize outreach facilitation, and advocacy for the adoption of bioethanol-based and liquified petroleum gas (lpg) cf-cs across participating households. the choice of cm strategy is deliberate because, unlike western culture, african cultures are largely based on communal hierarchy.

Eligibility criteria:
inclusion criteria: * primary adult must be a female cook; * must not have a paid housemaid; * family size must be a minimum of 2 and no more than 7 members; * family must use kerosene, charcoal, lpg, or firewood as primary cooking fuel; * the person spoken to at enrollment must be the home key decision maker; * must have no plans for relocation in the next year. exclusion criteria: • does not meet the inclusion criteria

Keywords: hypertension cardiovascular diseases clean cookstove clean fuel community mobilization household air pollution
evaluation of different diagnostic therapeutic strategies in patients with thyroid pathology

Conditions: Hypothyroidism; Hyperthyroidism/Thyrotoxicosis; Thyroid Nodule (Benign); Thyroid Carcinoma

Summary: observational single-center prospective and retrospective, nonpharmacological, spontaneous cohort study.

the study is observational single-center prospective and retrospective, nonpharmacological, spontaneous cohort study. this study will be offered to any patient with thyroid pathology (hypothyroidism, hyperthyroidism/thyrotoxicosis, benign thyroid nodule, and thyroid carcinoma) followed by our center with a minimum 3-month follow-up. in the retrospective phase, patients in whom thyroid pathology was diagnosed from 01/01/1995 until the approval of this study will be enrolled, while in the prospective phase those diagnosed from the time of the approval of this study to the next 10 years will be enrolled. in both phases, each patient will be followed for a maximum duate of 20 years. patients participating in the study will not undergo any procedure (laboratory or instrumental examination, examination or treatment) that is beyond the scope of normal daily clinical practice. likewise, the clinical variables that will be collected for the study are those that are commonly collected by the physician in daily clinical practice.

Eligibility criteria:
inclusion criteria: * age older than 18 years at the time of diagnosis; * patients with thyroid pathology (hypothyroidism, hyperthyroidism/thyrotoxicosis, benign thyroid nodule, and thyroid carcinoma) in whom the diagnosis was made in our center or another center from 01/01/1995 until the approval of this study (retrospective phase) or from the time of approval of this study to the next 10 years (prospective phase); * obtaining informed consent. exclusion criteria: * follow up lasting less than 3 months; * incomplete or missing clinical data that may affect the correct assessment of the patient.
abdominoplasty under spinal anesthesia

Conditions: Spinal Anesthesia Suitability for Abdominoplasty

Summary: 100 patients undergoing abdominoplasty under spinal anesthesia. 100 patients undergoing abdominoplasty under general anesthesia

200 patients, american society of anesthesiologists (asa) physical status classes i and ii, were enrolled in this feasible study. all patients were subjected to abdominoplasty operation under spinal anesthesia or general anesthesia. any intraoperative complications like hypotension, bradycardia, pain, nausea and vomiting related to spinal anesthesia were managed and recorded. postoperative visual analogue scale (vas) was used to assess pain severity and the need for analgesia to be administered.

Eligibility criteria:
inclusion criteria: * all patients between 18-55 years * asa i and ii exclusion criteria: * bmi more than 35 years * contraindications for regional anesthesia

Keywords: abdominoplasty spinal anesthesia general anesthesia postoperative pain
a comparative study between mechanical and a viscoelastic disc prosthesis in the lumbar spine

Conditions: Degenerative Disc Disease; Discogenic Low Back Pain

Summary: tdr implants for the lumbar spine are currently most 2- or 3-piece devices with a purely mechanical function that provide/restore mobility. lately interest is growing on non-mechanical implants that could possibly provide/restore mobility, but also produce counterforces on mobility as in healthy discs. no previous comparison between these two concepts has been performed, neither on clinical outcome, neither on specific differences on facet-joint load and wear.

a total of 250 patients are to be enrolled and treated. inclusion criteria is unbearable pain and dysfunction from degenerative disc disease (ddd) that at one or two segments in the lover lumbar spine, that has not responded positively from at least one year of conservative treatment (that is combination of intense physical training and drugs). patients with ddd below l3 vertebra are divided i three groups: 1. one segment ddd appropriate for treatment with tdr. 2. two segments ddd appropriate for treatment with tdr. 3. one segment ddd appropriate for treatment with tdr and one segment ddd not appropriate for treatment with tdr, that will be treated with anterior fusion (alif) at the same surgical procedure, called "hybrids". within all three groups there will be an equal randomization between the two prosthesis types. clinical outcome will be evaluated from questionnaires sent out to patients after 12- and 24 months and 5- and 10 years after surgery. the questionnaire are the currently used ones from the swedish spine registry (swespine) including vas leg/back, euroqol ,ga and odi. complications will be registered continuously and facet-joint load/health will be examined from flex-ext x-rays at 1 and 2 years. at the 2-year check up a 3d-ct will be performed to further evaluate the facet joints and their load under flex-ext.

Eligibility criteria:
inclusion criteria: * incapacitating pain from ddd (both clinical and radiological) in one or two segments below the l3 vertebra, were at least one segment is suitable for tdr treatment. * patient with more than one year of pain, that has during this period made a prolonged and adequate conservative program. -patient between 20 and 55 years of age. - -patient able to understand written and spoken swedish. exclusion criteria: * patient does not accept to be part of the study. * three or more segments suspected to be symptomatic. * earlier vertebral fracture, tumour, infection or fusion in the lumbar spine. -substantial scoliosis/deformity. * need for posterior decompression. * pregnancy, psychiatric illness or drug abuse. -patient does not understand written and spoken swedish and can thus not take part in information and answer questionnaires. -patient residing outside sweden and thus is not covered with swespine. -

Keywords: clinical outcome mobility facet-joints
the jenavalve align-ar pivotal trial

Conditions: Aortic Regurgitation; Aortic Valve Insufficiency; Aortic Insufficiency; Aortic Valve Disease

Summary: to collect information about treatment for symptomatic severe aortic regurgitation (ar), which affects the aortic valve in the heart. aortic regurgitation is a condition where aortic valve in the heart does not close tightly and allows some blood to leak back into the heart chamber. symptoms of aortic regurgitation may include fatigue and shortness of breath. the preferred treatment for severe aortic regurgitation is aortic valve replacement surgery.

this study will examine the use of tavr (transcatheter aortic valve replacement), which is a minimally invasive procedure designed to replace the aortic valve inside the heart. in this study, tavr will be performed using the jenavalve pericardial tavr system, which is intended to help treat symptomatic severe aortic regurgitation.

Eligibility criteria:
inclusion criteria: * patient with severe aortic regurgitation (ar). * patient at high risk for open surgical valve replacement * patient symptomatic according to nyha functional class ii or higher * the study patient has been informed of the nature of the study, agrees to its provisions and has provided written informed consent as approved by the institutional review board (irb)/ ethics committee (ec) of the respective clinical site. exclusion criteria: * congenital uni or bicuspid aortic valve morphology * previous prosthetic aortic valve (bioprosthesis or mechanical) implant * endocarditis or other active infection * need for urgent or emergent tavr procedure for any reason * cardiogenic shock or hemodynamic instability requiring inotropic support or ventricular assist device * severe mitral regurgitation

Keywords: valvular heart disease aortic incompetence aortic valve incompetence
concordance of imaging and pathology diagnosis of extranodal tumour deposits

Conditions: Adenocarcinoma of the Rectum

Summary: any patient with a suspected primary adenocarcinoma of the colon, sigmoid or rectum undergoing surgery are eligible. the date of surgery must be known prior to registration. this trial aims to determine if image mapping techniques can improve the concordance between imaging and pathology detection of tumour deposits. lymph nodes and tumour deposits will be identified on pre-operative scans and mapped by radiologists then shared with pathologists prior to processing the resected specimen. patients will be managed at their local hospital with standard follow-up. patients will be followed up for 5 years.

a prospective interventional multi-centre study, comet aims to prove the accuracy of imaging diagnosis of extranodal tumour deposits (td) and their adverse effect on prognosis of colorectal cancers. the proposed intervention will be additional radiological and pathological assessment and the reporting of supplementary diagnostic information which would not otherwise have been available. this may affect treatment according to local mdt protocols and also affect the provision of prognostic information to patients in subsequent discussions.

Eligibility criteria:
inclusion criteria: 1. suspected primary adenocarcinoma of the colon, sigmoid or rectum (proven by biopsy taken as part of routine clinical practice, patients to be withdrawn if not subsequently adenocarcinoma on pathology). 2. amenable to surgical resection. 3. disease spread assessed on imaging 4. patients having primary surgery and those undergoing neoadjuvant treatment will be included. 5. all must have had baseline staging scans and those undergoing neoadjuvant therapy must also have had a post-treatment scan. 6. patients aged 16 years and over exclusion criteria: 1. patients with recurrent tumours 2. synchronous tumours 3. under the age of 16 years 4. unable to give informed consent.

Keywords: mri tissue imaging pathology rectal cancer
mycobacteria registry study: prospective observational study in austria

Conditions: Non-Tuberculous Mycobacterial Pneumonia; Tuberculosis

Summary: the goal of this non-interventional registry study is to systematically collect epidemiological and clinical data throughout the treatment course to learn about effectiveness of treatments. we will document the natural course of therapy without additional interventions. the main question to answer is: what are the risk factors for mortality due to infection with mycobacteria tuberculosis (tb) or nontuberculous mycobacteria (ntm) in austria? data from participants already receiving treatment as part of their regular medical care for tb or ntm infections will be collected.


Eligibility criteria:
inclusion criteria: * patients diagnosed with mycobacterium tuberculosis or non-tuberculous mycobacteria infection * individuals aged 18 years or older * written informed consent exclusion criteria: * to not comprehend and rightfully judge participation

Keywords: mycobacterium tuberculosis nontuberculous mycobacteria mycobacterium infections