Kornimate/medical-research-clean huggingface dataset:
body composition measurements in pneumonia

Conditions: Acute Infection Respiratory

Summary: the purpose of this study is to validate and standardize bioelectrical impedance analysis (bia, maltron bioscan touch i8) for estimating body composition in hospitalized elderly patients with pneumonia. body composition assessments with bia and dual-energy x-ray absorptiometry (dxa,

holigic discovery) was performed on 36 non-fasting patients over 65 years of age. 29 patients had bia performed within 24 hours after hospital admission and at the date of discharge. 17 patients had bia performed in fasted state and one hour after an intake of 300 ml glucose solution.

Eligibility criteria:
inclusion criteria: * acute pneumonia, * accept participation (informed consent) * understand the given instructions and information exclusion criteria: * none
chf inpatient ambulation trial

Conditions: Heart Failure

Summary: there is an overwhelming amount of deconditioning that occurs during the hospitalization to a patient admitted with a primary diagnosis of congestive heart failure. the goals of this study are to determine if monitored activity and aggressive mobility provides improved outcomes in hospitalized heart failure patients.

by implementing an ambulatory study, the goal is to decrease the hospital length of stay by half of a day, decrease the percentage of patients being discharged to an extended nursing care facility, and improve quality of life for the patient. fiscal year 2014 the average length of stay for a chf patient at lancaster general health was 6.0, and as of fiscal year 2015 this was decreased to 5.8. according to harlan m krumbholz's theory of post hospital syndrome, patients are subjected to a time of increased risk of impaired stamina, coordination, strength and readmission for about thirty days after discharge due to deconditioning during their hospitalization. by implementing the ambulatory study, the hope is to prevent such extensive deconditioning to help improve the patient's quality of life after discharge; thereby reducing length of stay, discharges to skilled nursing facilities, 30 day readmissions and costs. the advent of wearable activity and/or health monitors in the health and fitness industry segment has the potential to revolutionize the industry. more importantly, these devices allow new variables to be collected to provide an impact on patients' care and outcome such as steps taken per day. the intention of the ambulation study is to prevent hospital acquired deconditioning; which in turn would not only decrease the length of stay, but also improve the discharge disposition and place them at home rather than hospice, an extended care facility or rehab. not only is the intent of the study to decrease the length of stay and also improve the patient's disposition, but also improve their quality of life. in addition, the study will test the effectiveness of the addition of a mobility aide to assist with patients walking on the nursing units.

Eligibility criteria:
inclusion criteria: * diagnosis of heart failure * the heart group as attending or consultant * patient on 5 west at the time of admission * admission diagnosis of heart failure * age ≥ 18 * initial assessment completed within 10 hours of admission by a registered nurse exclusion criteria: * patient admitted from acute rehabilitation or skilled nursing facility * altered weight bearing or unable to complete initial 2 minute walk test * unwilling or unable to participate or consent * acute delirium or dementia by history * hospice or actively dying * ventricular assist device or listed for heart transplantation * inotrope dependence * active ischemia * heart rate (hr) \ 130 at rest * blood pressure (bp) \ 180 at rest * pulse oximetry \<88% at rest * patient is in isolation for multi-drug resistant organism such as mrsa or c-diff

Keywords: wearable device fitbit inpatient
effect of cheese on cardiovascular risk

Conditions: Hyperlipidemia

Summary: the main objective of the current study is to examine whether a high intake of regular-fat cheeses (danbo and cheddar) affect blood lipids differently than an isocaloric intake of either other fatty animal food products or of starchy carbohydrates. furthermore, effects on fat digestibility, blood pressure, anthropometry, bile acid metabolism and insulin sensitivity is investigated. to do this, a randomized crossover intervention study with 3x14 days full diet periods (cheese diet, meat diet or carb diet)will be conducted in 16 postmenopausal women. between the diet periods there will be at least 14 days of wash-out where the subjects eat their habitual diets. fasting blood samples will be drawn before and after the diet periods, and also a non-fasting blood sample will be drawn after the diet periods. furthermore, total feces is collected the last 5 days of each diet period.


Eligibility criteria:
inclusion criteria: * female gender * postmenopausal for \>1 year * age 45-68 years * bmi 25-32 kg/m2 * tc \> 4.5 mmol/l and \< 7 mmol/l * systolic blood pressure \<160 mmhg and/or diastolic blood pressure \<100 mmhg exclusion criteria: * chronic diseases (known diabetes; cvd; other chronic diseases which could affect the results of the present study) * milk allergy * nut allergy * use of dietary supplements incl. multivitamins (2 months before and during the entire study period) * smoking * elite athletes (\>10 hours of strenuous physical activity per week) * use of prescription medicine which could affect the results of the present study including systemic glucocorticoids * use of lipid-lowering agents * stable dose of antihypertensive medication \>3 months before study commencement for subjects with high blood pressure * hormone replacement therapy * blood donation \<1 month before study commencement and during study period * simultaneous participation in other clinical studies * inability (physically or psychologically) to comply with the procedures required by the protocol

Keywords: dairy cheese blood lipid concentrations blood lipid sizes fecal fat fat digestibility bile acids
effects of playtraining in adhd preschoolers on adhd symptoms and play persistence and intensity

Conditions: ADHD

Summary: a sample of 60 children is randomly assigned to an intervention and a control condition. the intervention group receives 15 sessions of child-focused treatment with play training to enhance play persistence and intensity. the control group receives the same amount of placebo play sessions. the intervention group receives subsequently 15 sessions of parent training. all children are 3 to 6 years old and meet diagnostic criteria for add or adhd. main hypothesis are a stronger reduction of adhd symptoms of the child in different settings in the intervention than in the control group. play-persistence and -intensity should also increase more in the intervention group. an additional effect of a subsequent parent training shall furthermore be tested.


Eligibility criteria:
inclusion criteria: diagnosis of adhd or combinde adhd/ odd, age 3 to 6, 5 items regarding play behavior on dsm-iv symptom checklist above 95th percentile, parents motivation to provide 15 to 30 weekly sessions exclusion criteria: autism spectrum disorder, iq below 80, massive actual impairment, that requests sudden in-patient treatment, school entry in less than 2 months

Keywords: adhd preschoolers playtraining child-focused intervention
the plasticity of social brain network in adults with autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: "social brain" refers to brain regions dedicated to processing social information and enabling us to recognize and evaluate others' mental states. the social brain hypothesis suggests that our brains evolve to navigate complex social systems. the social brain is hypothesized to consist of a distributed network including the posterior superior temporal sulcus (psts), the dorsal and ventral medial prefrontal cortices (dmpfc and vmpfc), acc and posterior cingulate cortex (pcc), the amygdala, the orbital frontal cortex (ofc), and the fusiform gyrus (fg), tpj, inferior occipital gyrus (iog), and the insula. each region serves distinct role while works together to support social processing, including perceiving, interpreting, and generating responses to the intentions, dispositions, and behaviors of others.


Eligibility criteria:
inclusion criteria: * age between 18 and 50 * diagnosed with asd from licensed mental health or medical professional based on dsm5 * have social problems * motivated to participate in the treatment * fluent in chinese * caregiver also fluent in chinese and motivated to participate * had a full-scale iq \> 70 on wais-iv * scored ≧ 26 on the caregiver-reported autism spectrum quotient (aq), indicating clinical impairment associated with asd. exclusion criteria: * history of major mental illness, such as bipolar affective disorder, schizophrenia, psychosis, or neurological diseases * visual impairment and/or hearing impairment * any metal, electronic part that cannot be removed from the body, or being pregnant, which may not be able to use fmri scan.
progressive mobilization with dose control and training load in in critically ill patients

Conditions: Critically Ill

Summary: immobilization and bed rest of patients in intensive care units (icu) increases their risk for muscle dysfunction and prolonged mechanical ventilation, leading to physical deconditioning and loss of functionality. active mobilization is a therapeutic strategy that typically involves exercises in which the patient uses his or her own strength and muscular control, is a feasible, safe, and low-cost intervention to improve muscle dysfunction and disability in patients at the icu. despite scientific advances, the current description and prescriptions of exercises at the icu remain incomplete with respect to the control and the description of the variables of training load (volume and intensity), programming, and progression.

this prospective double-blind (patient and evaluator). this study will be conducted in accordance with consolidated standards of reporting trials recommendations. the trial will be performed at the university hospital professor edgard santos in salvador, bahia, brazil. this study was approved by the institutional hospital ethics committee (approval reference number 2.371.933). before enrollment, written informed consent will be obtained from participants or their legal guardians.

Eligibility criteria:
inclusion criteria: * being able to roll in the bed and bridge. * barthel score of at least 70 weeks before admission to the icu * ability to interact with the researcher exclusion criteria: * mortality rate in excess of 50% according to acute physiology and chronic health disease classification system ii (apacheii) * present intracranial pressure increase * cardiorespiratory arrest, * has unstable fractures that hamper progression in levels of mobilization, * severe lower limb injury or amputation * neuromuscular disease * underwent radiotherapy and / or chemotherapy in the last 6 months.
surgical reconstruction in ulcerative colitis with primary sclerosing cholangitis

Conditions: Ulcerative Colitis; Primary Sclerosing Cholangitis; Pouchitis; Complications

Summary: primary sclerosing cholangitis (psc) occurs in approximately 10 % of patients with ulcerative colitis (uc), but the outcome of reconstructive surgery is not clear. the purpose of this study was to determine the functional outcome after surgery, frequency of pouchitis, complications and failure-rate in uc-psc patients compared to patients with uc alone. both ileal pouch-anal anastomosis (ipaa) and ileo-rectal anastomosis (ira) were studied.

primary sclerosing cholangitis (psc) is characterised by inflammation and fibrosis of the biliary tree and the condition can lead to end-stage liver disease. psc is strongly associated with inflammatory bowel disease (ibd), with a prevalence of ibd in psc as high as 60-84 % in northern europe and north america. the majority of patients with ibd and psc have ulcerative colitis (uc). considering all patients with uc, around 30% will ultimately require surgery; the most common indications are acute colitis, chronic refractory disease or colorectal dysplasia. the standard procedure is proctocolectomy and ileal pouch-anal anastomosis (ipaa). however, ileo-rectal anastomosis (ira) or conventional ileostomy are options. the prognosis after surgery is generally considered good. previous studies have shown that the course of colitis in patients with uc/psc is different from that of patients with uc-only. in a patient with uc, several aspects have to be considered at counselling before surgery. however, in many aspects, the literature is substantial for patients with uc-only (for example function and quality of life after ipaa) and key information can be safely provided. conversely, patients with uc/psc that require colectomy are rare and as a consequence, data on most aspects is sparse (18-20). the aim of the study was to assess outcome after surgery (ipaa or ira) in patients with uc/psc. focus was on pouch/rectal function, pouchitis, surgical complications and failure. patients with uc-only were employed as controls.

Eligibility criteria:
inclusion criteria: * uc * psc * ipaa * ira exclusion criteria: * non-uc * non-psc * no consent

Keywords: ulcerative colitis primary sclerosing cholangitis ileal pouch-anal anastomosis ileorectal anastomosis surgical outcome functional outcome failure
effect of ric on cerebral autoregulation in patients undergoing cerebrovascular stent implantation

Conditions: Remote Ischemic Conditioning

Summary: the purpose of this study is to determine the effect of remote ischemic conditioning on cerebral autoregulation in patients undergoing cerebrovascular stent implantation.

in this study, 104 cases of patients with cerebrovascular stent implantation will be enrolled in the first hospital of jilin university, and they will be divided into the ric group and the sham-ric group. the ric group received remote ischemic conditioning for 200mmhg, 2 times per day for 7 consecutive days or from enrollment to discharge. the sham-ric group received remote ischemic conditioning for 60mmhg, 2 times per day for 7 consecutive days or from enrollment to discharge. two groups will be followed up to evaluate the effect of remote ischemic conditioning on cerebral autoregulation in patients undergoing cerebrovascular stent implantation.

Eligibility criteria:
inclusion criteria: * age≥18 years, regardless of sex; * patients with symptomatic or asymptomatic cerebral vascular stenosis (including internal carotid artery system and vertebrobasilar system) who are candidates for elective cerebrovascular stenting. * patients or their immediate family members are able and willing to sign informed consent. exclusion criteria: * patients with progressive stroke; * mrs≥ 2 points before admission; * patients with other surgical treatments; * patients with other serious diseases or a life expectancy of less than 3 months * patients who had contraindication of remote ischemic conditioning, such as severe soft tissue injury, fracture or vascular injury in the upper extremities, venous thrombosis in the acute or subacute stage of upper extremities; * laboratory test indicators are unqualified: aspartate aminotransferase or alanine aminotransferase is 3 times higher than the upper limit of the normal range, blood creatinine \> 265umol/l (\>3mg/dl), platelet \< 100×109/l, international normalized ratio (inr), activated partial thromboplastin time (aptt), prothrombin time (pt) exceed the upper limit of the normal range; * pregnant or lactating women; * patients who are participating in other clinical studies, or who have participated in other clinical studies within 3 months prior to enrollment; * unwillingness to be followed up or poor adherence to treatment; * other circumstances that the investigator considers unsuitable for enrolment.

Keywords: remote ischemic conditioning cerebrovascular stent implantation
a compassionate use study of tenofovir disoproxil fumarate as treatment for hiv infection

Conditions: HIV Infections

Summary: this study allows patients who need a new anti-hiv treatment to take tenofovir disoproxil fumarate (tenofovir df), an experimental drug. this study also looks at any side effects the drug causes.

hiv-1-infected patients who are currently receiving stable antiretroviral therapy add tenofovir df to their regimen. study participation lasts for approximately 48 weeks. interested patients should contact their physicians.

Eligibility criteria:
inclusion criteria you may be eligible for this study if you: * are hiv-positive. * have a viral load greater than or equal to 10,000 copies/ml. * have a cd4 count less than or equal to 50 cells/mm3, or have a cd4 count greater than 50 and no more than 200 cells/mm3 with an opportunistic (aids-related) infection within 90 days of study entry. (patients with a cd4 count above 200 cells/mm3 may be considered depending on drug supply.) * are at least 18 years old. * agree to use barrier methods of birth control (such as condoms) while on the study and for 30 days afterward. * have a life expectancy of at least one year. exclusion criteria you will not be eligible for this study if you: * have a history of a serious kidney or bone disease. * have severe nausea, vomiting, or trouble taking medications by mouth. * are pregnant or breast-feeding. * abuse alcohol or other substances that your doctor thinks would interfere with taking this medicine. * are taking any medicines that interfere with kidney functions.

Keywords: hiv-1 drug therapy, combination disease progression anti-hiv agents
kl₄surfactant treatment in patients with ards

Conditions: Acute Respiratory Distress Syndrome

Summary: lung wash with kl₄surfactant of individual lung segments using a bronchoscope compared to usual care alone consisting primarily of assisted (mechanical) ventilation in patients with acute respiratory distress syndrome(ards).

this is a multinational, multicenter, two-part, phase 2 study that will evaluate the tolerability, safety, and efficacy of kl₄surfactant in adult ards patients when administered by sequential bronchoscopic lavage into each of the 19 bronchopulmonary segments of the lung and as a bolus instillation into each lung.

Eligibility criteria:
inclusion criteria: * intubated and required mechanical ventilation support * met the criteria for ards * partial pressure of oxygen/fraction of inspired oxygen (pao2/fio2) ≤ 200 mmhg and ≥ 60 mmhg within 60 minutes before randomization * mean blood pressure was ≥ 60 mmhg immediately before randomization exclusion criteria: * had ards due solely to a major trauma * was currently participating in another clinical trial or received an experimental drug or device within the previous month * a woman of childbearing age, unless pregnancy was excluded by a negative urine hcg test or if the subject was surgically incapable of childbearing * had a previous episode of ards that resolved and then recurred during the current hospitalization * had a disease that was sufficiently advanced, in the best judgment of the principal investigator, to markedly limit life expectancy to \< 6 months * was known to have aids or symptomatic hiv (cd4 counts \<500). subjects with asymptomatic hiv were not excluded * received chemotherapy or radiation within the previous 90 days * received an organ transplant other than corneal transplants * received, or was currently receiving, immunosuppression therapy within the last 6 months * had severe neurological damage or the presence of a disease that was likely to significantly prevent weaning from the ventilator * had a best glasgow coma score (gcs) of ≤ 8 or an intracranial pressure ≥ 20 cm h2o prior to the institution of sedatives or paralysis
epidemiological assessment of technical diving accidents in mainland france and factors predictive of severity (tekcare)

Conditions: Decompression Sickness; Pulmonary Edema - Acute; Oxygen Toxicity; Carbon Dioxide Poisoning; Nitrogen Narcosis

Summary: this retrospective study aims at an epidemiological description of the clinical presentation of medical problems in technical diving. it assess anthropometric data, diving experience and dive planification, clinical presentation, treatment received and pronostic to understand specificity of this community.

in recent years, the increased availability of breathing gas mixtures, together with progressive technical development of specialized diving equipment, has contributed to expansion of the diver's community. deep and long dives expose to decompression sickness (dcs) risk and hyperbaric oxygen therapy (hbo) is the definitive treatment. incidence, clinical expression or prognosis of pathological events after technical diving might differ from recreational ones. a better knowledge of these specificity will facilitate risk assessment, analysis and medical care for hyperbaric physician community.

Eligibility criteria:
inclusion criteria: * civilian technical diver * diving accident history (decompression sickness, biochemical accident or immersion pulmonary edema) following a technical dive in a trimix and/or rebreather dive * treated in a hyperbaric center on the coast of mainland france exclusion criteria: * participation denied by the diver * diving incident diagnosis not retained by the hyperbaric physician
indocyanine green fluorescent cholangiography and intraoperative angiography with laparoscopic cholecystectomy

Conditions: Cholecystitis; Chronic Calculous Cholecystitis; Acute Calculous Cholecystitis

Summary: this was a double blinded, randomized, controlled trial involved patients underwent laparoscopic cholecystectomy

a double blinded, randomized, controlled trial involved patients underwent laparoscopic cholecystectomy in ain-shams university specialized hospital in the period from january 2020 till july 2021. group a (n=60) underwent laparoscopic cholecystectomy using the usual white light, group b (n=58) underwent laparoscopic cholecystectomy with icg florescence cholangiography and intraoperative icg florescence arteriography.

Eligibility criteria:
inclusion criteria: * adults (from 18 to 75 years old) * suffering from a gall bladder disease * with valid indication for laparoscopic cholecystectomy (e.g., calculus gall bladder with cholecystitis) * accepted to participate in the study. exclusion criteria: * patients with history of previous biliary surgery * patients with abdominal malignancy * patients with advanced chronic liver disease * pregnant women

Keywords: laparoscopic cholecystectomy indocyanine green fluorescent cholangiography indocyanine green fluorescent angiography