Kornimate/medical-research-clean huggingface dataset:
clinical efficacy of single-use of peroxyl mouthwash for reducing bacteria saliva and bioaerosol contamination phase 2

Conditions: Healthy

Summary: to evaluate the antibacterial efficacy of a commercial mouthwash containing 1.5% hydrogen peroxide in reducing the levels of bacteria in bioaerosols generated by dental prophylaxis.

following a washout period, subjects will return to the clinical site. a baseline microbial sample will be collected from the operatory's atmosphere for 30 min. prior to the study subject appointment by placing blood agar plates on a support board attached to the bracket chair tray. upon completion of a half-mouth (e.g. right side) dental prophylaxis, each study subject will be instructed to rinse for one minute with 10 ml of one of the two mouthwash solutions (1.5% hydrogen peroxide or 0.0% hydrogen peroxide) and to expectorate all remaining liquid. next, the dental prophylaxis will be completed on the other side of the mouth. bioaerosol samples will be collected prior to and following rinsing on blood agar plates placed on a support board at a 50-degree angle to the participant's chest, on the participant's chest, and on the examiner's forehead. plates will be closed and labeled. the plates will be transferred to the microbiology laboratory for analysis. all subjects will be followed for adverse events throughout the study.

Eligibility criteria:
inclusion criteria: * potential subjects must meet all of the following criteria: * subjects, ages 18-70, inclusive. * availability for the duration of this clinical research study. * good general health. * at least 20 natural teeth. * gingivitis index 1.0 (löe-silness). * signed informed consent form exclusion criteria: * potential subjects must not have any of the following conditions: * symptoms consistent with covid-19 or have tested positive. * presence of orthodontic bands. * tumor(s) of the soft or hard tissues of the oral cavity. * advanced periodontal disease (purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone) or peri-implantitis. * five or more carious lesions requiring immediate restorative treatment. * use of antibiotic one-month prior to entry into the study. * participation in any other clinical study or test panel within the one month prior to entry into the study. * dental prophylaxis during the past two weeks prior to baseline examinations. * history of allergies to oral care/personal care consumer products or their ingredients. * on any prescription medicines that might interfere with the study outcome. * an existing medical condition that prohibits not eating or drinking for periods up to 4 hours. * history of alcohol or drug abuse. * self-reported pregnant or lactating subjects.

Keywords: mouthwash saliva bioaerosol bacteria gingivitis
an observational clinical study of the t3 dental implant system

Conditions: Edentulous Jaw

Summary: this will be a prospective, observational study where all implants will be placed in either the maxilla or mandible and loaded immediately (within 48 hours), early (within 6-8 weeks) or delayed (\> 8 weeks) with a provisional or definitive prosthesis. the implants will be evaluated yearly for 2 years.

this study aims to enroll a total of 140 patients (140 implants) who are in need of treatment with dental implants in one or more edentulous areas of the maxilla and/or mandible. approximately 4 sites will be participating, each one contributing 35 patients to the study dataset. the main objectives of this study will be: 1. the integration success of the dental implant (as measured by mobility) 2. the measured changes in peri-implant crestal bone levels for each implant 3. confirmation of clinical benefits

Eligibility criteria:
inclusion criteria: 1. patients of either sex and at least 18 years of age. 2. patients for whom a decision has already been made to use a dental implant for the restoration of existing edentulism in the mandible and/or maxilla. 3. prior extracted sites or simultaneous extraction/implant placement. 4. patients must be physically able to tolerate conventional surgical and restorative procedures. 5. patients who provide a signed informed consent. 6. patients who agree to be evaluated for each study visit. exclusion criteria: 1. patients who are known to be pregnant at the screening visit or planning to become pregnant within 6 months of study enrollment. 2. patients who have previously failed dental implants at the site intended for study implant placement. 3. patients with active hiv or hepatitis infection.
spermatogonial stem cells in azoospermic patients: a comparison between obstructive and non-obstructive azoospermia

Conditions: Male Infertility

Summary: the researchers hypothesized that nonobstructive azoospermia might be associated with a reduction of sscs in seminiferous tubules as compared with obstructive azoospermia. testicular sperm specimens that had been previously extracted from azoospermic patients will be paraffin embedded and stained with anti gpr-125. after antigen retrieval, the sections will be incubated with rabbit anti gpr125 followed by cy3-conjugated anti rabbit secondary antibodies. those found to be sscs will be counted using light microscopy, and compared between patients with obstructive (n=11) and non-obstructive azoospermia (n=9).


Eligibility criteria:
inclusion criteria: * azoospermic patients exclusion criteria: * patients with sperm cells
hyperglycemia and the extra-pancreatic effect of incretins

Conditions: Extra-pancreatic Incretin Effect; Glucose Effectiveness

Summary: incretin hormones (glp-1 and gip) released from the intestine in response to meal ingestion augment insulin secretion from the pancreas to help maintain glycemic control. studies in vitro and in vivo have shown that these incretin hormones also have functional effects in other tissues independent of the insulin secretory response. both glp-1 and gip stimulate insulin secretion in a glucose-dependent manner, however the glucose-dependency of their extra-pancreatic effects has not been examined in vivo. by using pancreatic clamp methodology during euglycemic and hyperglycemic conditions we will test the hypothesis that extra-pancreatic effects of glp-1 and gip are glucose-dependent.


Eligibility criteria:
inclusion criteria: * age 18-60 years * bmi 18-30 kg/m2 * male * normal glycemic control (fasting glucose \<5.6 mm) exclusion criteria: * evidence of chronic disease * smoking * active weight loss (\>2 kg in previous 6 months) * treatment with drugs known to affect our outcome varaibles
sudden sensorineural hearing loss in wonju severance christian hospital

Conditions: SSNHL(Sudden Sensory Neural Hearing Loss); Sudden Hearing Loss; Hearing Loss, Idiopathic Sudden Sensorineural; Hearing Loss, Sudden

Summary: this study is to build a cohort of sudden sensorineural hearing loss (ssnhl) patients. when the patient visited the department of otolaryngology clinic for hearing loss, we can diagnose the ssnhl following the result of pure tone audiometry and the history of the patient. the cohort is a system that tracks the hearing recovery status, timing, and degree of recovery of patients who received cocktail therapy with or without high-dose steroids, vasodilators, antiviral agents, and intratympanic steroid injections, satellite ganglion block, and hyperbaric oxygen therapy.


Eligibility criteria:
inclusion criteria: * adult patients over 20 years of age * a patient who visited wonju severance christian hospital, department of otolaryngology and was diagnosed with sudden hearing loss as it was confirmed that hearing loss of 30dbhl or more occurred within 3 days at three consecutive frequencies in a pure tone audiometry test. * those who have fully explained the purpose and content of the study and voluntarily agreed to the written consent exclusion criteria: * if the patients do not want to or do not fill out the consent form * if treatment is started for sudden hearing loss, but the possibility of other inner ear diseases including meniere's disease is suspected due to repeated hearing loss, repeated recovery, dizziness, tinnitus, etc. * other cases where it is judged difficult to carry out the clinical trial due to the judgment of the person in charge of the above clinical trial

Keywords: hearing loss hearing loss, sudden ssnhl sudden sensorineural hearing loss sudden sensory neural hearing loss
tissue and plasma biomarkers of lymph node involvement in cervical cancer

Conditions: Cervical Cancer

Summary: the purpose of this study is to measure the levels of serum proteins and other biomarkers in cervical cancer patients. we believe that some of these markers may be useful in selecting patients for specific types of cancer therapies. these markers may also help to predict response to therapy, relapse after therapy, and survival after therapy.

specific study aims specific aim 1: to use gene expression analysis of primary cervical cancers to identify a gene expression signature that predicts for lymph node metastases in this disease. specific aim 2: to predict lymph node metastases by performing multiplex measurements of cancer-associated proteins and cytokines using proximity ligation assay (pla) on plasma samples. specific aim 3: to measure circulating human papilloma virus (hpv) dna in the plasma samples of cervical cancer patients using real-time quantitative polymerase chain reaction (qpcr) and determine its ability to predict for nodal metastases. specific aim 4: to use deep sequencing to evaluate gene and sequence differences between cervical cancer patients with and without lymph node metastasis.

Eligibility criteria:
inclusion criteria: * patients must have a known or suspected cervical cancer. * age \>=18 years. * patients must have no other active cancer at the time of diagnosis. * patients must have no history of a hysterectomy. * patients must be able to give informed consent. * patients must be willing to undergo a biopsy of the cervical tumor to provide tissue for the study. * patients must have completed a standard-of-care fdg-pet/ct prior to initiation of therapy, for assessment of lymph nodes. exclusion criteria: - pregnant women
sevoflurane effect on left atrial performance: a transoesophageal echocardiographic study

Conditions: Ischemic Heart Disease

Summary: the left atrial performance is affected by the preload as well as the afterload. the la active pumping is increased by stretching of the la but within limits, after which the active pumping declines. the lv stiffness acts as the la afterload. whenever the lv stiffness increases, the overall emptying fraction becomes more pumpdependent

the echocardiographic assessment of the la was frequently overlooked. while left atrial performance reflects both systolic and diastolic functions of the lv, it looks like more studies are being conducted to detect the effect of different interventions on the left atrial size and function. other studies focus on the prognostic value and the ability to risk stratify different cohorts of patients, based on the early recognition of deranged la performance. many studies were conducted on the effect of inhalational anesthetics on the left atrial function. yet the results are inconclusive and sometimes contradictory. in a study on dogs, gare meir and his colleagues proved that desflurane, sevoflurane, and isoflurane depress left atrial contractility, delay relaxation, reduce chamber stiffness, preserve reservoir and conduit function, and impair left atrial-left ventricular coupling in vivo. volatile anesthetics may cause impairment of both left atrial (la) and left ventricular (lv) contractility. the mechanisms suggested were a decrease in the influx of calcium via voltage gated calcium channels as well as a decrease in calcium availability from sarcoplasmic reticulum.echocardiographic assessment of the la volumetric measures is comparable to that of cardiovascular magnetic resonance (cmr) with clinically irrelevant difference. this makes echocardiographic assessment of la volumes reliable, cheaperand easier to obtain.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of ischemic heart disease * elective coronary artery bypass grafting. exclusion criteria: * atrial or ventricular dysrhythmias, * associated mitral valve disease, * ejection fraction \<40%, * emergency coronary artery bypass grafting, * pericardial disease * contraindication to perform a tee, e.g. esophageal tumor
non invasive ventilation as airway clearance in patients with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: with the use of non invasive ventilation the patients with cystic fibrosis will have better lung function (fev1).

3 months intervention between pep an bilevel. the patients will follow up under 3 months.

Eligibility criteria:
inclusion criteria: * patients with cf older than 18 years * fev1 between 20% and 69% of predictive. * no acute exacerbation. * no burkhordelia cepacia/mrsa colonization. exclusion criteria: * children under 18 year * acute exacerbation.

Keywords: lung function
noninvasive hemoglobin repeatability and reproducibility in a blood donation setting

Conditions: Healthy; Anemia

Summary: the primary objective of this clinical investigation is to report on the repeatability and reproducibility of sphb measurements from rad-67 devices and dci mini sensors used to screen prospective blood donors at a donation center.


Eligibility criteria:
inclusion criteria: * at least 18 years of age * weight at least 110 pounds * subjects with the intention of being screened for eligibility to donate blood * the subject has given written informed consent to participate in the study exclusion criteria: * subjects with skin abnormalities at the planned application sites that may interfere with sensor application, per directions-for-use (dfu) or trans-illumination of the site, such as burns, scar tissue, infections, abnormalities, etc. * subjects unwilling to remove nail polish or acrylic nails * subjects with blood cancers such as leukemia * subjects with hemoglobin disorders such as sickle-cell anemia and thalassemia or with known history of infectious diseases such as hiv/aids, syphilis, hepatitis, etc. * subjects with self-disclosed/known pregnancy at the time of enrollment * subjects deemed not suitable for the study at the discretion of the investigator * subjects unlikely to be able to refrain from excessive motion during data collection. excessive motion includes postural changes, making hand gestures, involuntary muscular movements, etc.
18f-fapi pet imaging in pancreatic adenocarcinoma

Conditions: 18F-FAPI; 18F-FDG; Pancreas Adenocarcinoma; Diagnosis; Staging

Summary: to explore the potential efficacy of 18f-fapi-04 pet/ct for pdac tumour staging and compare the results with those obtained using 18f-fdg pet/ct.

accurate diagnosis and staging are crucial for selecting treatment for patients with pancreatic ductal adenocarcinoma (pdac). the desmoplastic responses associated with pdac are often characterised by hypometabolism. here we investigated 18f-fibroblast activation protein inhibitor (18f-fapi-04) positron emission tomography/computed tomography (pet/ct) in evaluation of pdac, and compared the findings with those obtained using (18f)-fluorodeoxyglucose (18f-fdg).

Eligibility criteria:
inclusion criteria: patients who were suspected to have pdac by radiological imaging patients who underwent paired 18f-fapi-04 pet/ct and 18f-fdg pet/ct for metastasis screening, recurrence confirmation, or tumour staging patients who were willing to participate in clinical trials and signed an informed consent form. exclusion criteria: patients with a history of severe contrast allergy pregnant patients patients who were not pathologically diagnosed as showing pdac.
ercp plus laparoscopic cholecystectomy versus laparoscopic common bile duct exploration and cholecystectomy

Conditions: Common Bile Duct Calculi

Summary: around 10-18% of patients undergoing cholecystectomy for gallstones have common bile duct (cbd) stones. currently, various procedures for the treatment of cholecystocholedocholithiasis are available including open cholecystectomy plus open common bile duct exploration (oc+ocbde), laparoscopic cholecystectomy plus laparoscopic common bile duct exploration (lc+lcbde), may be trans-cystic or trans-choledochal, and laparoscopic cholecystectomy plus endoscopic retrograde cholangiopancreatography (lc+ercp), which may be performed pre, at, or after lc.

around 10-18% of patients undergoing cholecystectomy for gallstones have common bile duct (cbd) stones. currently, various procedures for the treatment of cholecystocholedocholithiasis are available including open cholecystectomy plus open common bile duct exploration (oc+ocbde), laparoscopic cholecystectomy plus laparoscopic common bile duct exploration (lc+lcbde), may be trans-cystic or trans-choledochal, and laparoscopic cholecystectomy plus endoscopic retrograde cholangiopancreatography (lc+ercp), which may be performed pre, at, or after lc. single-session treatment of gallbladder and cbd stones is safe, efficient, shortens hospital stay, and is less expensive than staged procedures. although there is some evidence suggesting that lcbde may be associated with a lower rate of retained stones compared with ercp, previous studies comparing lcbde with ercp and stone extraction have collectively failed to demonstrate the superiority of one approach over the other.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed with cholecystocholedocholithiasis 2. american society of anesthesiologists (asa) scores of i-iii 3. age 20-70 years. exclusion criteria: 1. cholangitis, 2. acute biliary pancreatitis, 3. suspected mirizzi syndrome, 4. suspected hepatobiliary malignancy, 5. perforated gallbladder, 6. biliary peritonitis, 7. intrahepatic stones, 8. pregnancy, 9. previous cholecystectomy, 10. altered anatomy such as billroth ii reconstruction or any form of roux-en-y reconstruction that interfere with the endoscopic approach, 11. contraindications to laparoscopic surgery as severe liver cirrhosis or upper abdominal surgery were excluded.

Keywords: endoscopic retrograde cholangiopancreatography laparoscopic common bile duct exploration laparoscopic cholecystectomy single operator cholecystocholedocholithiasis
impact of clear aligners and metal brackets on nutritional status

Conditions: Malocclusion

Summary: this study aims to investigate the effect of clear aligners and traditional brackets on the nutritional status of orthodontic patients. with the increasing demand for more aesthetic and comfortable orthodontic appliances among adults, clear aligner treatment has gained popularity as an alternative to traditional fixed appliances. however, limited research has been conducted to evaluate the impact of clear aligners on dietary habits and nutrition. the study will include adult participants undergoing orthodontic treatment with either clear aligners or traditional brackets. anthropometric measurements, dietary assessments, and oral health impact evaluations will be conducted to assess the nutritional status of the participants. the findings of this study will contribute to a better understanding of the influence of orthodontic appliances on nutrition and guide clinicians in providing comprehensive care to orthodontic patients.


Eligibility criteria:
inclusion criteria: * adult individuals (18 - 45 years old) * undergoing orthodontic treatment, without missing teeth in the mouth (excluding wisdom teeth) * having received orthodontic treatment for more than 6 months * citizens of the republic of turkey * proficient in reading and writing in the turkish language * not under the influence of alcohol or drugs * able to understand and follow instructions for filling out the questionnaire * willing to participate in the study exclusion criteria: * adult individuals (18 - 45 years old) * undergoing orthodontic treatment, without missing teeth in the mouth (excluding wisdom teeth) * having received orthodontic treatment for more than 6 months * citizens of the republic of turkey * proficient in reading and writing in the turkish language * not under the influence of alcohol or drugs * able to understand and follow instructions for filling out the questionnaire * willing to participate in the study

Keywords: tooth crowding nutritional status orthodontic brackets clear aligner appliances
evaluation of the relevance of comparative genomic hybridization in prenatal diagnosis

Conditions: Comparative Genomic Hybridization

Summary: pre-natal diagnosis is developing nowadays thanks to the improvement of ultrasound performances but also of genetic analysis techniques. the karyotype was previously the reference technique for genetic analysis. the development of comparative genomic hybridization, consisting of comparative genomic hybridization on dna sequences and allowing the diagnosis of unbalanced chromosomal rearrangements, has made it possible to increase the resolution threshold for the detection of genetic anomalies. this technique can be performed both pre and post natal. in pre-natal, the indications for this genetic study are based on ultrasound signs and are regularly updated in the international literature. due to the complete analysis of the genome and the increase of the resolution threshold, genetic anomalies not related to the detected ultrasound pathology may be discovered and may pose ethical problems from a genetic counseling point of view. to date, the diagnostic performance of comparative genomic hybridization as a complement to karyotype is being confirmed and needs to be clarified in order to limit the risk of incidental discovery of genetic anomalies whose significance remains unknown. through the study that the investigator would like to carry out, the investigator seek to evaluate the diagnostic contribution of this comparative genomic hybridization technique compared to the data provided by the karyotype according to the various ultrasound call signs on the nancy cohort of files presented to the multidisciplinary pre-natal diagnosis committee, since the launch of the comparative genomic hybridization in nancy in 2012 until 2018.


Eligibility criteria:
inclusion criteria: * cgh-array performed for ultrasound findings at the genetic laboratory of the nancy university hospital from 01/10/2012 to 31/12/2018 * results of the cgh-array presented to the multidisciplinary pre-natal diagnosis committee of nancy exclusion criteria: * patients who objected to the use of their data for research purposes when signing the informed consent form given during the genetic consultation

Keywords: prenatal diagnosis ultrasound sign
the expression profile of new complement components in childhood lupus nephritis

Conditions: Lupus Nephritis

Summary: the aim of this study was to evaluate whether c4d is a better biomarker and examine whether c4d plasma levels correlate with treatment response and c4d kidney deposition in systemic lupus erythematosus (sle) with lupus nephritis (ln).

evaluation of c4d in lupus nephritis in children c4d level difference in children with systemic lupus with and without renal affection c4d level in lupus nephritis at activity and after remission detection of c4d deposition in renal tissue relation to disease activity

Eligibility criteria:
inclusion criteria: * this will include children and adolescents who fulfill the 2012 systemic lupus international collaborating clinics (slicc)(10) classification criteria of sle. * inclusion criteria: * age younger than 18 years. * active sle with and without renal affection * patients with biopsy proven ln according to isn/rps classification criteria of lupus nephritis. exclusion criteria: * -patients in remission.
effects of combined alcohol and nitrous oxide intake - 15

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Summary: the purpose of this study is to determine the effects of combined alcohol and nitrous oxide intake on mood, psychomotor performance, and the pain response in healthy volunteers.


Eligibility criteria:
please contact site for information.

Keywords: nitrous oxide ethanol drug interaction subjective effects healthy volunteer