Kornimate/medical-research-clean huggingface dataset:
spsip block in breast surgeries for postoperative analgesia

Conditions: Postmastectomy Pain

Summary: the aim of this clinical study is to demonstrate that pain following breast surgeries can be reduced through the application of serratus posterior superior intercostal plane block (spsipb). seven patients scheduled for breast surgery were included in the study. the primary research question it seeks to address is as follows: • can spsipb be applied to reduce pain following breast surgeries? participants are expected to provide accurate responses to the researcher's questions for the assessment of postoperative pain.

postoperative analgesia techniques for breast surgeries encompass options such as paravertebral block, erector spinae plane block, serratus anterior plane block, and pectoral nerve blocks. although the paravertebral block is considered the gold standard for postmastectomy pain relief, its limited usage is primarily attributed to complications. spsipb's potential in thoracic surgeries has been noted, offering a broad sensory block suitable for mrm and axillary lymph node dissection. in this study, the effectiveness of spsip block for post-mastectomy pain has been investigated.

Eligibility criteria:
inclusion criteria: * female patients who will undergo breast surgery exclusion criteria: * unstable patients * patients with bleeding disorders * patients allergic to local anesthetic drugs * patients who did not agree to participate in the study * patients with infection at the application site

Keywords: serratus posterior superior intercostal plane block regional anaesthesia postmastectomy pain interfascial plane blocks
examining the experiences of brain injury patients in medical trials

Conditions: Brain Injuries

Summary: historically, participation in clinical trials has been skewed towards certain groups. however, research on the factors that influence participation, both positive and negative, is limited. brain injury clinical trial patients help us identify these factors by sharing trial experiences during the course of the interventional medical study. this study will include a diverse group of participants to gather a wide range of information on clinical trial experiences. the collected data will then be used to benefit future brain injury patients who are considering participating in a medical study.


Eligibility criteria:
inclusion criteria: * patient has been diagnosed with brain injury * patient is 18 years old * patient has self-identified as planning to enroll in an interventional clinical trial exclusion criteria: * patient does not understand, sign, and return consent form * patient is pregnant * inability to perform regular electronic reporting

Keywords: brain injuries
double-blind lamictal (lamotrigine) in neurotic excoriation

Conditions: Neurotic Excoriation; Pathologic Skin Picking; Psychogenic Excoriation; Dermatillomania

Summary: the goal of the proposed study is to evaluate the comparative efficacy of lamictal (lamotrigine) to placebo in neurotic excoriation. thirty subjects with neurotic excoriation will receive 12 weeks of double-blind treatment with lamictal (lamotrigine) or matching placebo. the hypothesis to be tested is that lamictal (lamotrigine) will be more effective than placebo in patients with neurotic excoriation. the proposed study will provide needed data on the treatment of a disabling disorder that currently lacks a clearly effective treatment.

the study will consist of 12 weeks of double-blind treatment with lamictal (lamotrigine) compared to placebo (1:1) in 30 subjects with neurotic excoriation.

Eligibility criteria:
inclusion criteria: 1. men and women age 18-65; 2. current diagnosis of neurotic excoriation. exclusion criteria: 1. unstable medical illness or clinically significant abnormalities on prestudy laboratory tests or physical examination; 2. history of seizures; 3. myocardial infarction within 6 months; 4. current pregnancy or lactation, or inadequate contraception in women of childbearing potential; 5. a need for medication other than lamictal with possible psychotropic effects or unfavorable interactions with lamictal; 6. clinically significant suicidality; 7. lifetime history of dsm-iv bipolar disorder type i, dementia, or schizophrenia or any other dsm-iv psychotic disorder; 8. current or recent (past 3 months) dsm-iv substance abuse or dependence; 9. illegal substance use within 2 weeks of study initiation; 10. initiation of psychotherapy or behavior therapy from a mental health professional within 3 months prior to study baseline; 11. previous treatment with lamictal (lamotrigine); 12. treatment with investigational medication or depot neuroleptics within 3 months, with fluoxetine within 6 weeks, or with other psychotropics within 2 weeks prior to study baseline; 13. current treatment with an anti-epileptic medication.

Keywords: neurotic excoriation pathologic skin picking psychogenic excoriation
veın imagıng devıce and vırtual realıty

Conditions: Pain, Acute; Emotional Distress; Fear; Anxiety State

Summary: the aim of this study was to evaluate the effect of a vein imaging device and virtual reality distraction on the success of peripheral intravenous catheter (pic) placement, intervention duration, emotional appearance, pain, fear, and anxiety related to pic intervention in children aged 4-10 years in a pediatric emergency unit.

the children were divided into four groups: control group, vein imaging group, virtual reality group, and vein imaging and virtual reality group. the duration of the intervention and the number of pic interventions performed on each patient were recorded. the children were assessed before and after the procedure using the emotional appearance scale for children. after the procedure, the child fear scale and child anxiety scale-state were used to evaluate the most painful moment experienced by the child during the procedure using the wong-baker faces (wb-faces) and color analog scale.

Eligibility criteria:
inclusion criteria: * children between the ages of 4-10 * the child agrees to voluntarily participate in the study. * parents agree to voluntarily participate in the study * obtaining consent from the child and parent exclusion criteria: * need for urgent resuscitation * having a fever (\>37.5c) and severe dehydration * the fact that the patient had taken analgesics before the pic intervention.
a pilot study of romidepsin in relapsed or refractory extranodal nk/t-cell lymphoma

Conditions: Histologically Proven Extranodal NKTcell Lymphoma

Summary: extranodal nk/t-cell lymphoma is a rare disease entity with aggressive clinical course and poor prognosis. currently, there is no treatment option for relapsed or refractory extranodal nk/t-cell lymphoma. romidepsin is a histone deacetylase inhibitor which was approved for cutaneous t-cell lymphoma. a recent phase ii study of romidepsin for relapsed/refractory peripheral t-cell lymphoma reported an overall response rate of 38% (95% confidence interval 24%-53%). the median duration of overall response was 8.9 months. considering the median number of previous treatments in these patients was three (range 1-11), romidepsin has single agent activity against relapsed/refractory t-cell lymphoma. thus, if the single agent activity of romidepsin is demonstrated, it could be a therapeutic agent for combination with salvage treatment.


Eligibility criteria:
inclusion criteria: 1. patient should belong to any one of following clinical situations 1. relapsed after salvage chemotherapy 2. relapsed after autologous stem cell transplantation 3. refractory to salvage chemotherapy or autologous stem cell transplantation 2. adequate organ function as defined by the following criteria: 1. serum aspartate transaminase (ast; serum glutamic oxaloacetic transaminase (sgot)) and serum alanine transaminase (alt; serum glutamic pyruvic transaminase (sgpt)) ≤2.5 x local laboratory upper limit of normal (uln), or ast and alt less than or equal to 5 x uln if liver function abnormalities are due to underlying malignancy 2. total serum bilirubin ≤ 1.5 x uln 3. absolute neutrophil count (anc) ≥1500/µl 4. platelets ≥ 75,000/µl 5. hemoglobin ≥ 9.0 g/dl (may be transfused or erythropoietin treated) 6. serum calcium ≤ 12.0 mg/dl 7. serum creatinine ≤ 1.5 x uln 3. at least one measurable lesion 4. ecog ps 0-2 5. written informed consent 6. over 20 years and under 80 years of age exclusion criteria: 1. previously received allogeneic stem cell transplantation 2. history of or known carcinomatous meningitis, or evidence of symptomatic leptomeningeal disease or secondary cns involvement on ct or mri scan. 3. ongoing cardiac dysrhythmias of nci ctcae grade ≥2. 4. pregnancy or breastfeeding. 5. any known cardiac abnormalities 6. hbv carrier 7. positive for hiv

Keywords: extranodal nktcell lymphoma
randomized control trial (rct) of early palliative care for hcc

Conditions: Carcinoma, Hepatocellular

Summary: the purpose of this research study is to evaluate the effect of early palliative care consultation on quality of life, use of hospital resources, end-of-life care and survival among hepatocellular carcinoma (hcc) patients with advanced end stage live disease not eligible for potentially curative or local area therapy. half of patients will receive early palliative care at diagnosis of hcc and other half will receive palliative care when all standard therapy treatments have been exhausted.

intro: hypothesis methods analysis anticipated results palliative care will focus on providing relief from the symptoms and stress associated from cancer. this helps improve quality of life for cancer patients and their family. this care is usually offered to patients when all standard therapy treatments have been exhausted.

Eligibility criteria:
inclusion criteria: * diagnosed hcc by biopsy or liver protocol ct scan or mri characteristics * permanent street address with harris county, texas and consent to study participation * english or spanish speaking with ability to respond to the qol questionnaires * child-pugh c, not eligible for liver transplantation (txp), surgical resection, ablation, locoregional or systemic therapy * child-pugh c, eligible for systemic chemotherapy (sorafenib), not eligible for txp, surgical resection, ablation or locoregional therapy * child-pugh a or b, not eligible for surgical resection or ablation (\>3 lesions or 2 lesions with one being \>5cm) * child-pugh a, not eligible for txp, surgical resection, ablation or locoregional therapy exclusion criteria: * primary modality of treatment is potentially curative txp, surgical resection or ablation as deemed by gi mdc * child-pugh a or b (up to 2 lesions \< 5cm in size) * medical (e.g. severe encephalopathy), psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results * any medical condition (acute myocardial infarction or stroke) that could jeopardize the safety of the patient and his/her compliance in the study * vulnerable population (inmates in jail or prison) * non-english or non-spanish speaking patients.

Keywords: liver cancer randomized control trial palliative care liver cell carcinoma palliative therapy
the use of nomegestrol acetate/estradiol in random start rapid endometrial preparation

Conditions: Endometrial Polyp; Endometrial Diseases

Summary: the presence of a thin endometrium plays an important role in enabling the best conditions for hysteroscopic surgery. recently, for this purpose, many studies have evaluated the effect of preoperative administration of a variety of drugs. we explored the efficacy of random started 14-day administration of nomegestrol acetate/estradiol, in rapid preparation of endometrium for hysteroscopic polypectomy.


Eligibility criteria:
inclusion criteria: * patients with endometrial polyps. exclusion criteria: * patients with other endometrial pathologies.

Keywords: hysteroscopy endometrial preparation
digital support for people with cognitive impairment

Conditions: Cognitive Impairments; Stroke; Brain Injuries

Summary: cognitive impairment may cause problems in planning and initiating daily activities, as well as remembering to do what is scheduled. this study investigates the effectiveness of an interactive web-based mobile reminder calendar, (remindme). the calendar sends text messages to the user's mobile phone as support in everyday life, for persons with cognitive impairment due to neurological injury/diagnoses. the study has a randomized controlled trial design with data collection at baseline and at follow-up sessions after two and four months. data collection started in october 2016 and continued until february 2018. remindme may give the needed support to remind the person and thus increase the ability to perform activities and to become independent in everyday life.


Eligibility criteria:
inclusion criteria: * participants with cognitive impairment after stroke or other neurological diseases/injury * participants experiencing the need for support in planning, organizing and remembering to do activities in everyday life * participants having access to a computer and mobile phone/smartphone * participants having linguistic ability to participate in assessments exclusion criteria: * participants with palliative care needs * participants with reduced vision and/or hearing loss that affects the ability to use a mobile phone/smartphone * participants with depression or psychiatric illness

Keywords: self-help devices occupational therapy
virtual reality for the treatment of chronic low back pain

Conditions: Back Pain Lower Back Chronic

Summary: chronic low back pain is highly prevalent in us adults and is a major cause of missed work days and disability. while several treatment options exist, chronic opioids are commonly used for these conditions even though there are limited data supporting efficacy, and clear evidence of harm associated with chronic opioid administration. virtual reality has been proposed as a treatment option that may lead to decreased pain and improved physical functioning, while avoiding the harms associated with medication management. this study is intended to obtain preliminary safety and efficacy data to guide the design of a larger clinical trial.

this is a pilot study to evaluate the safety and efficacy of the kauruna virtual reality program for the treatment of chronic low back pain. this study is intended to document the safety and efficacy of the use of virtual reality for the treatment of chronic low back pain. the primary outcome measure will be physical functioning as measured by the promis 6. secondary outcome measures include patient-reported pain intensity, adverse side effects, disability as measured by the oswestry low back disability questionnaire, and mental functioning as assessed using the phq-9 and gad-7. finally, impact on opioid use in patients on chronic opioids will be assessed by documentation of daily opioid dose in oral morphine equivalents. forty adult patients with chronic low back pain who are receiving care through the penn pain medicine center are eligible to participate in the study. the study will consist of a screening visit, followed by randomization into 1 of 2 study groups. both study groups will participate in two 20-minute virtual reality sessions a week for 8 weeks. study group 1 will participate in 20 minutes of mindfulness mediation. study group 2 will undergo initial sessions focused on graded motor imagery, followed by sessions focused on graded exposure. patient-reported outcomes data will be obtained at baseline, then weekly during the 8-week study period, then 4 weeks following completion of the study sessions.

Eligibility criteria:
inclusion criteria: * age over 18 * able to speak and read english * a history of chronic low back pain for at least 6 months * no changes to medications within 30 days of randomization * able to provide outcomes data through the electronic patient-reported outcome data collection system exclusion criteria: * age less than 18 years. * pregnant women * cognitive impairment that limits ability to participate in the study, including the provision of outcome data through the electronic patient-reported outcome data collection system. * unable to stand for at least 15 minutes * employees or students of the university of pennsylvania
a quality of life study in patients undergoing percutaneous biliary drainage

Conditions: Malignant Biliary Obstruction

Summary: the purpose of this study is to compare the participant's health-related quality of life before and after the biliary drainage procedure. the study will also help us learn whether having a drainage catheter or a stent placed during the procedure makes a difference in the participant's quality of life.


Eligibility criteria:
inclusion criteria: * patients with known malignancy presenting for treatment of biliary obstruction * undergoing initial interventional radiology pbd procedure * fluent in english to enable instrument completion * at least18 years of age * must be physically and mentally capable of completing instruments * must be able to comprehend and execute informed consent exclusion criteria: * patients will be excluded if: * indication for drainage is acute, symptomatic cholangitis requiring an emergent procedure * previous pbd procedure * presence of an indwelling biliary stent * medical or psychiatric condition that, in the judgment of the consenting professional, prevents appropriate comprehension and execution of either the informed consent or the study instruments

Keywords: percutaneous biliary drainage quality of life 18-366
school-based comprehensive suicide intervention in shanghai, china

Conditions: Suicide

Summary: the primary aim of this study is to examine whether a school-based suicide intervention is effective in reducing suicide related risk factors in a population of middle and high students. it hypothesized that receiving the intervention will reduce the severity of suicide related risk factors such as depression, hopelessness, suicidal behaviors and increasing protective factors such as social support, self esteem, suicide knowledge and attitude and so on, as compared to the control group.

a total of 3000 students from two junior schools (grade 7 and 8) and two senior schools (grade 10 and 11) in shanghai pu dong district were recruited in our study. all students were randomly assigned into universal study group or universal control group by class level. in those two groups, high risk of suicidal students were identified by screening. a universal suicide intervention was conducted in the universal study group; an indicated suicide intervention was conducted in the indicated study group. all students in universal study group and universal control group completed the self-administered questionnaire before and 6 months after the end of universal intervention. high risk of suicidal students in the indicated study group and indicated control group completed another self-administered questionnaire before, 6 months and 18 months after the end of the indicated intervention.

Eligibility criteria:
inclusion criteria: * students of grade 6,7,9,10 from four schools (2 middle schools, 2 high schools) exclusion criteria: * students who are not attending school because of long term sickness or moving to other school,or going aboard, etc. * students whose parents don't agree to participate the study

Keywords: school-based adolescent suicide intervention screening
an absorbable suture versus a non-absorbable suture in carpal tunnel release, a randomized controlled trial

Conditions: Carpal Tunnel Syndrome; Median Nerve Entrapment

Summary: the study compares two widely used treatments in closing the wound after open carpal tunnel release surgery: absorbable and non-absorbable sutures. it is conducted as a randomized controlled trial, where the participants are divided into two research groups. the visual outcome of the scar will be evaluated a year after the surgery.

absorbable sutures are more cost efficient and eliminate the need for suture removal both reducing costs and abolishing suture removal pain. we will study the difference in the visual outcome between the two groups. based on former study the primary hypothesis is that there is no difference between the groups. the patients will evaluate their scars on a vas-scale one year after the surgery. secondarily we will focus on pain caused by the two sutures and take the suture removal pain into consideration. we expect therefore the non-absorbable suture to cause more pain in total. the evaluation will happen 2 weeks after the surgery by the patients.

Eligibility criteria:
inclusion criteria * carpal tunnel syndrome diagnosed with electro near my-graphs * symptoms typical of carpal tunnel syndrome * referral to carpal tunnel release * informed consent signed * the ability to receive the virtual questionnaire via email and answer it * the ability to understand and answer the finnish questionnaires exclusion criteria * repeat surgery * known allergy to suture materials * ongoing systemic steroid treatment * ongoing chemotherapy * ongoing immunomodulatory treatment * past hypertrophic or keloid scars or other severe disturbances in wound healing * age under 18, pregnancy or breastfeeding

Keywords: carpal tunnel carpal tunnel syndrome median nerve release median nerve entrapment surgery suture absorbable non-absorbable
daily topical rapamycin for vitiligo

Conditions: Vitiligo

Summary: in current dermatology practice, options for vitiligo remain limited. the purpose of this study is to determine if once daily dosed topical rapamycin is effective for the treatment of patients with vitiligo. participants will apply either 0.1% topical rapamycin or 0.001% topical rapamycin for six months to a lesion on one side of the body, and topical placebo to a corresponding lesion on the opposite side of the body. the study also aims to evaluate patient satisfaction and identify any adverse effects on these dosing regimens.


Eligibility criteria:
inclusion criteria: * patients 13 years of age and older * patients with nonsegmental vitiligo exclusion criteria: * patients with segmental or mucosal vitiligo * patients with contraindication to use of rapamycin * patients with history of transplant * patients with a history of natural immunodeficiency * patients with a history of artificially induced immunodeficiency * patients with a history of a serious or life-threatening infection * patients taking cyp3a4 inhibiting medications * patients taking strong cyp3a4 inducers * patients undergoing current treatment for vitiligo * women that are or may become pregnant

Keywords: dermatology pediatrics rapamycin