Kornimate/medical-research-clean huggingface dataset:
acute plasma abeta responses to stress

Conditions: Stress Reaction; Stress Physiology

Summary: research has shown that activation of the sympathetic nervous system for extended periods or during certain times in life can increase the risk for alzheimer's disease. some research in animal models show that acute activation of the sympathetic nervous system through stress exposure can increase certain alzheimer's disease-related biomarkers, such as amyloid-beta, within hours of exposure. however, how acute sympathetic nervous system activation via stress exposure affects amyloid-beta levels in humans has yet to be examined. in this study, the investigators will examine whether brief increases in sympathetic activation result in immediate changes in plasma amyloid-beta levels in the five hours after exposure.

aim 1: determine whether acute exposure to stress (increasing sympathetic nervous system activation) increases plasma amyloid-beta-40 and amyloid-beta-42 in the five hours following exposure.

Eligibility criteria:
inclusion criteria: * healthy adult weighing at least 110 pounds * no chronic conditions or illness * taking no medications or drugs that might alter the stress response (e.g., corticosteroids, beta-blockers, and others) * not using any hormone-containing medication (e.g., hormonal contraceptives, hormone replacement, etc.) * no contraindications for cold pressor test exposure (high blood pressure, heart disease, dysrhythmia, peripheral vascular disease, any other cardiovascular disorder, diabetes, vasculitis, lupus, tingling or numbness in the hands and/or feet, cryoglobulinemia, and reynaud's phenomenon) * no history of fainting during blood draws * no phobia of having their blood drawn * no general history of fainting or seizures * not currently diagnosed with a mood disorder (e.g., major depressive disorder) * not pregnant in the past 12 months * not lactating in the past 12 months * not trying to become pregnant if premenopausal * experienced natural menopause if postmenopausal * be non-smokers * be fluent in english exclusion criteria: - unwilling to be filmed during the stress task or unwilling to sign the waiver allowing their filmed responses to be used in scientific presentations

Keywords: stress reaction stress amyloid-beta
comparison of fatigue in varying hot environments

Conditions: Hyperthermia

Summary: the purpose of this study is to determine the impact of varying hot environments on physiological and perceptual fatigue during work.

after providing written informed consent and screening, subjects will complete two experimental visits during which they will complete treadmill work in either a hot/dry or warm/humid environment.

Eligibility criteria:
inclusion criteria: * 18-39 y old men and women * self-reported to be healthy exclusion criteria: * history of any cardiovascular, neurologic, renal, or metabolic disease * current tobacco use or regular use within the last 2 years * current musculoskeletal injury * taking medications with known thermoregulatory or cardiovascular effects (e.g., aspirin, acetaminophen, ibuprofen, beta blockers, diuretics, psychotropics, etc.) * currently pregnant or breastfeeding, or planning to become pregnant during the study * inability to follow the rules of the protocols or understand the consent form * contraindications of consuming a core temperature monitoring pill
protein ingestion on bmm response in endurance runners

Conditions: Dietary Proteins; Acute Exercise; Bone Diseases, Metabolic

Summary: the goal of this clinical trial is to investigate the effects of protein ingestion post-exercise on bone turnover markers. the main questions it aims to answer is: does protein ingestion independently influence the bone metabolic response to exercise in endurance runners? we will compare dietary protein to a placebo (water) to detect changes in bone turnover markers. participants will: in a within-subject design, participants will perform an exhaustive run and take either protein or placebo immediately post-exercise. track physical activity and diet before each arm of the intervention and during the washout period.

endurance athletes are at increased risk for bone loss and injury due to high-volume training, muscle weakness, and elevated nutritional demand. dietary practices influence short- and long-term bone health and nutrition supplementation post-exercise may improve the short-term response of bone to exercise and benefit musculoskeletal recovery. however, we have a limited understanding of which dietary practices are most beneficial to optimize bone health in athletic populations. protein supplementation has long been recommended for muscle adaptation and athletic performance but its potential for bone health has not been thoroughly investigated in endurance athletes. the purpose of this study is to is to investigate the acute independent effects of dietary protein ingestion on bone metabolism in healthy adults aged 18-35 years participating in high-volume endurance running.

Eligibility criteria:
inclusion criteria: * 18-35 years of age * healthy-range body mass index (bmi) (18.5-24.9 kg/m2) * competitive runner for at least one season (minimum 40 km/week for the past 6-months) * can read, speak, and understand french and/or english exclusion criteria: * disease or medication known to affect bone metabolism * disease (e.g., uncontrolled thyroid disease, malabsorptive or inflammatory disorder, metabolic bone disease) * medication (e.g., hormonal contraceptives the past 3 months, glucocorticoids, anti-hypertensive drugs, anti-epileptic drugs, osteoporosis therapy) * orthopedic or musculoskeletal injury/disease that limits the capacity to exercise * current smoker or tobacco user * current diagnosis of an eating disorder * female participants with self-reported or diagnosed: * hypothalamic amenorrhea * polycystic ovarian syndrome * hyperprolactinemia * primary ovarian insufficiency * pregnant or breastfeeding * donated blood within the past two months
esophageal monitoring device for assessing mucosal impedance

Conditions: GERD; Esophagitis

Summary: the investigators are looking at a novel approach to measuring gastroesophageal reflux disease (gerd) damage and reducing the need for costly and less optimal testing presently used for diagnostic and treatment purposes. the investigators will be using three custom mucosal impedance (mi) catheters, each designed to measure at slightly different spacing on the esophagus.

during routine esophagogastroduodenoscopy (egd), consented study participants will have a series of three (3) custom mucosal impedance (mi) catheters with an axial array of sensors positioned along the mucosal wall to directly measure mucosal impedance at various intervals. each catheter will be manually guided by the physician through the working channel of the endoscope until the sensored tip is visible through the scope camera. the physician will place the sensored rings directly on the mucosa along the lumen. to obtain evaluable data, the sensors must remain in contact with the mucosa at each point for 5 seconds after a stable impedance reading has been captured. this process will be repeated for each of the three prototype catheters in each consented patient in order to determine the optimal catheter/sensor design. the catheters will be attached to a channeled feed that will record measurements on a dedicated computer.

Eligibility criteria:
inclusion criteria: * patients who are undergoing standard of care egd with or without bravo placement; * have gerd symptoms and/or have endoscopic esophagitis exclusion criteria: * use of acid suppressive therapy within last 10 days; * known history of barrett's esophagus, gastric surgery, alcoholism, significant motility condition

Keywords: gerd esophagitis
synchromed ii post-approval study

Conditions: Severe Spasticity; Chronic Pain

Summary: this fda condition of approval study will include up to 100 subjects at up to 13 us centers. subjects are selected from those evaluated and planning to receive a synchromed ii drug infusion system for treatment of severe spasticity or chronic pain. subjects must return for refill visits at 1, 6, and 12 months. in addition, subjects return for any other medically necessary refills. information is collected on all refills and adverse events.


Eligibility criteria:
inclusion criteria: * have chronic intractable severe spasticity or chronic pain requiring intrathecal delivery of medication * have undergone a pre-implant assessment and determined to be an appropriate candidate for implantation of an infusion system * be geographically stable and willing to return to the study center for follow-up visits * subject, or subject's legal representative, has signed informed consent form prior to any study-related procedures * age is at least 18 years of age at time of enrollment exclusion criteria: * have a condition in which the pump cannot be implanted 2.5 cm or less from the surface of the skin * have an ongoing infection prior to implant * have insufficient body mass to accept the pump bulk and weight * are unable or unwilling to adhere to the study protocol * have an estimated life expectancy of less than twelve months

Keywords: infusion pump implantable performance
effects of colesevelam hcl, rosiglitazone, sitagliptin on control of blood glucose and lipids in type 2 diabetes patients whose blood glucose isn't completely controlled with metformin

Conditions: Type 2 Diabetes; Hyperlipidemia

Summary: a 16 week open-label study with subjects receiving background metformin monotherapy. 150 subjects randomized 1:1:1 to receive 1 of the following: open-label colesevelam hcl, open label rosiglitazone, or open-label sitagliptin.


Eligibility criteria:
inclusion criteria: * hba1c 7.0 % to 10.0% on metformin monotherapy; may be withdrawn from other (non-metformin) drugs if hba1c is 6.5% to 9.5 % at screening. exclusion criteria: * subjects currently treated with a thiazolidinedione are excluded.

Keywords: colesevelam hcl, rosiglitazone sitagliptin type 2 diabetes metformin
morpho-functional changes after oral supplementation of antioxidants and anti-inflammatory treatment in age-related macular degeneration.

Conditions: Dry AMD

Summary: in patients with amd a deterioration of the antioxidant mechanisms of the retina is observed and therefore an increase in the production of free radicals responsible for tissue damage. the age-related eye disease study (areds) found that the intake of antioxidants reduces the risk of progression of the disease to an advanced stage (choroidal neovascularization or geographic atrophy ) and reduces the loss of visual acuity. in this study the investigators want to analyze the functional retinal changes (mferg) of the macular region, in patients with dry age-related macular degeneration, after the use for 6 months of an oral supplementation based on ganoderma lucidum (reishi), calendula officinalis, lutepure-marigold ( 5% lutein and 1% zeaxanthin) blueberry, rutin, alpha-lipoic acid, bromelain, nac, vtiamine c, b9, b12, d3, selenium, zinc and copper.


Eligibility criteria:
inclusion criteria: * age\> 50; * dry amd not in therapy with oral supplements or antioxidants * visual acuity ≥ 20/40 * ability to provide written informed consent and to follow the procedures of the study; exclusion criteria: * spherical refractive error greater than ±6 diopters * cylindrical refractive error greater than ±3 dioptres * opacity of diopter means * any active or past retinal pathology other than amd * history of ocular surgery (\<6 months) * pregnancy

Keywords: oral supplementation mferg oct
icp waveform analysis in stroke patients

Conditions: Stroke

Summary: this is a study on how acute clinical state and final clinical outcome in patients with stroke (exclusive subarachnoid hemorrhage) relate to icp/abp-derived pressure waveform parameters recorded during intensive care management.

aim of study: * prospectively collect clinical and radiological data as well as management data. * perform retrospective analysis of icp/abp recordings (mean icp, mean icp wave amplitude, mean abp, mean abp wave amplitude, cpp) * relate the prospectively collected data with results of retrospective pressure analysis.

Eligibility criteria:
inclusion criteria: * acute apoplexy exclusion criteria: * subarachnoidal bleeding

Keywords: apoplexia intracranial and intraarterial pressure curves in acute apoplectic patients
peri-articular nerve group block versus fascia iliaca block on postoperative pain after hip arthroscopy

Conditions: Analgesia

Summary: the study aims to evaluate the efficacy of pericapsular nerve group block versus fascia iliaca block in reducing post operative pain within the first 24 hours following hip arthroscopy

in recent decades hip arthroscopy gained popularity and the number of procedures increase every year , due to the widening range of indications, as femoroacetabular impingement, labral tears, chondral injuries, loose bodies, osteonecrosis and septic arthritis pain after hip arthroscopy due to several factors. divided in two regions. first the intra-articular where pain originates from the joint capsule (capsulotomy), a repaired labrum or bony resection. outside the joint caused by traction, the portal tracts and extravasation of irrigation , soft tissue swelling. the hip joint found to be innervated from the femoral nerve for its anterior part, the obturator nerve for its antero-medial part, the sciatic nerve for its posterior part, and the nerve to the quadratus femoris muscle for its postero-medial par pericapsular nerve group (peng) block aims to block the articular branches of the accessory obturator and femoral nerve also, it could spread to block the obturator nerve and its articular branches the high articular branches from fn and aon are found between the anterior inferior iliac spine(aiis) and the ilio pubic eminence (ipe), whereas the on is located close to the inferomedial acetabulum. the fascia iliaca compartment is a virtual space anteriorly limited by the posterior surface of the fascia iliaca, posteriorly by the iliacus muscle and is cranially in continuation with the space between quadratus lumborum muscle and its fascia . three important nerves for hip innervation are located in this space, the femoral nerve, obturator nerve and lateral femoral cutaneous nerve

Eligibility criteria:
inclusion criteria: age 16-60 years old asa physical status i or ii scheduled for hip arthroscopy exclusion criteria: * pregnancy or breast feeding * neurological deficits or neuropathy * opioid addict * local skin infections, bleeding diathesis, and coagulopathy

Keywords: post operative pain hip arthroscopy
a pilot study to assess the impact of a camstent coated catheter on clinical bacteriuria

Conditions: Bacteriuria

Summary: a pilot study to assess the impact of a camstent coated catheter on clinical bacteriuria when compared to an uncoated catheter. each participant will take part in the trial from the time the participant signs the informed consent form (icf). after the screening visit, the participants will be allocated to either a coated catheter or an uncoated catheter. participants will be assigned to receive trial treatment until the catheter has been removed, investigator's decision to withdraw the subject, noncompliance with trial treatment or procedures, unacceptable adverse event, or participant withdraws consent. during the trial urine samples will be taken form the catheter port, temperature will be taken, and participants and healthcare providers will be asked to complete questionnaires.


Eligibility criteria:
inclusion criteria: * require insertion or exchange of a urinary catheter in a suprapubic position as a component of their routine clinical care as per guidelines * patients aged 18+ years will be eligible for the study. * patient understands and is willing to participate in the study and is able to comply with study procedures and visits. exclusion criteria: * patients that have or recently (within 3 weeks) had a urinary catheter and displays symptoms of current urinary tract infection.2. patients that have asymptomatic infection (if required may need a blood test to confirm) * pregnant or breastfeeding. * patients with a potentially immunocompromised conditions (hiv) * has a known silicone allergy or sensitivity * use of investigational drug or device within four weeks prior to study entry that may interfere with this study. * any medication deemed by the investigator to potentially interfere with the study treatment * participation in any other clinical study. * has a known bloodstream infection or an infection that requires prolonged antibiotic therapy
trial of non invasive ventilation for respiratoy distress syndrome

Conditions: Prematurity; Respiratory Distress Syndrome

Summary: the purpose of this study is to evaluate the hypothesis that nasal intermittent positive pressure(nipp), used as a primary mode of ventilation in preterm infants with rds, will decrease the need for conventional endotracheal ventilation when compared to nasal continuous positive airway pressure.(ncpap)

respiratory distress syndrome(rds) and its sequelae, bronchopulmonary dysplasia(bpd) are complications of prematurity.the pathogenesis of bpd is multifactorial and one of the most important risk factors is the ventilator-induced lung injury caused by invasive respiratory support. the two modes of non-invasive ventilation, nipp and specially ncpap, have been used frequently in the respiratory care of preterm infants in neonatal units.ncpap is currently a common practice for the treatment of rds . nipp has been found to be more effective than ncpap in apnea of prematurity and immediately after extubation in preterm infants,decreasing the need of endotracheal ventilation. alternative techniques of non-invasive ventilation has been suggested in some studies to decrease respiratory morbidities associated with prematurity.this non-invasive approach could be used initially as a primary mode of ventilation for infants with rds in a effort to decrease lung injury and bpd.studies are needed to compare the effectiveness of these therapies.

Eligibility criteria:
inclusion criteria: * preterm infants with rds * assigned to non invasive ventilation exclusion criteria: * preterm on endotracheal ventilation * severe congenital pulmonary or cardiovascular malformation

Keywords: non invasive ventilation mechanical ventilation pulmonary morbidity preterm infant respiratory distress syndrome nasal intermittent positive pressure nasal continuous positive pressure bronchopulmonary dysplasia
cardiac arrhythmias in patients undergoing kidney cancer surgery depending on the anaesthesia method

Conditions: Arrhythmia, Cardiac; Kidney Cancer; Surgery; Anesthesia, Local

Summary: this study evaluates the incidence of cardiac arrhythmias during the perioperative period in patients undergoing open kidney cancer surgery in the lateral position. all the participants will be randomly allocated to receive general (group g) or combined epidural/general anaesthesia (group g/e). the anaesthetic technique is standardized. the holter monitor will be applied at the evening before the surgery, tracing continuously for a period of 24 hours (7pm-7pm)

cardiac arrhythmias are a common complication during and after cardio-thoracic surgery. they are also a major source of morbidity and mortality. after general surgery, they usually do not require clinically significant management but the literature on this topic is obsolete. there is no literature data about their incidence during kidney surgery in the lateral position when the bed is scissored so the legs and head are low. the aim of this study was to define what types of arrhythmias are the most common during kidney cancer surgery, their incidence and whether combining general with epidural anesthesia prevents them. an approval from the medical university of warsaw bioethical committee has been obtained. patients need to give written informed consent to participate in the study. it is anticipated that 50 patients with open kidney cancer surgery performed in the lateral position, under general or combined anesthesia will be enrolled. a holter ecg monitor (3-chanel, leads cm5) will be applied at the evening before the surgery, tracing continuously for a period of 24 hours (7pm-7pm). patients will be randomly allocated (random permuted blocks within strata) to receive general or combined epidural/general anesthesia. the anesthetic technique is standardized. all the data registered by the holter ecg monitor will be analyzed and compared with the nursery and anesthesia records.

Eligibility criteria:
inclusion criteria: * open renal cell carcinoma surgery, lateral position * american society of anesthesiologists (asa) physical grade i-iii * no history of cardiac arrhythmias * informed consent exclusion criteria: * pregnancy and breast feeding * contraindications for epidural anesthesia * laparoscopic or robotic surgery * suspected difficult intubation (ex. fibroscopic) * chest deformations * prior cardiac/thoracic surgery * cardiac insufficiency * abnormal ecg before the surgery

Keywords: cardiac arrhythmia epidural anesthesia combined anesthesia general anesthesia nss radical nephrectomy extraperitoneal
efficacy of non-invasive high power laser acupuncture stimulation in chronic non-specific low back pain

Conditions: Low Back Pain

Summary: this study will be conducted to answer the following question: does high power laser acupuncture has any effect on pain, back range of motion, function, quality of life, fatigue and level of satisfaction in chronic nonspecific low back pain patients?

the aims of this study are: 1. to investigate the effect of high power laser acupuncture on pain in chronic nonspecific low back pain patients 2. to investigate the effect of high power laser acupuncture on back range of motion (flexion, extension, side bending and rotation) in chronic nonspecific low back pain patients. 3. to investigate the effect of high power laser acupuncture on function in chronic nonspecific low back pain patients. 4. to investigate the effect of high power laser acupuncture on quality of life in chronic nonspecific low back pain patients. 5. to investigate the effect of high power laser acupuncture on back muscle fatigue in chronic nonspecific low back pain patients. 6. to investigate the effect of high power laser acupuncture on level of satisfaction in chronic nonspecific low back pain patients.

Eligibility criteria:
inclusion criteria: subjects will be included in this study will be having all of the following criteria: 1. age over 18 years of age. 2. both genders (males and females). 3. normal bmi ranges between 18.5:24.9 kg/m2. 4. patients will be referred from an orthopedist with diagnosis of chronic low back pain without underlying pathological causes. the patients with chronic nonspecific low back pain more than 3months. minimum pain intensity of 30 mm on the visual analogue scale (vas) for pain, which ranges from 0 to 100 mm. 6) cnslbp patients will be diagnosed based on the standard criteria, including pain and tenderness on lower back and a negative result for all special tests for lumber neurological examination. exclusion criteria: 1. history of any surgical procedure in the back or the lower extremities. 2. back pain secondary to known specific pathology (e.g. infection, tumor, osteoporosis, fracture, structural deformity, inflammatory disorder (e.g. ankylosing spondylitis) or cauda equine syndrome). 3. patient with lumbar instability including spondylolisthesis. 4. red flags (e.g. fever, unexplained weight loss, progressive weakness, radiation to lower limb, bowel and bladder dysfunction). 5. pregnancy.

Keywords: chronic low back pain high-intensity laser therapy high power laser acupuncture