Kornimate/medical-research-clean huggingface dataset:
comparative effects of dry needling and ischemic compression technique on scalene myofascial pain syndrome

Conditions: Scalenus Syndrome

Summary: myofascial pain syndrome (mps) is a medical term used to describe chronic regional pain syndrome that presents with hyperirritable spots called trigger points (tps) and/or tender spots (tss) that arise from taut bands (tb) in the skeletal muscle. scalene myofascial pain syndrome is a regional pain syndrome wherein pain originates over the neck area and radiates down to the arm. functionally, mps causes the muscle to become weak and stiff, leading to reductions in range of movement. thus, mps is known as a major cause of morbidity, with a significant impact on daily activity, function and quality of life. the aim of this study is to compare the effects of dry needling versus ischemic compression technique on trigger points of scalene in neck pain, related disability and neck active range of motion among patients with scalene myofascial pain syndrome.

a randomized clinical trial will be conducted at dhq gujranwala and sikandar medical complex gujranwala through convenience sampling technique on 24 patients. patients with scalene myofascial pain syndrome between age from 18 years to 45 with positive scalene cramp test will be included in study. patients will be accessed for neck pain, disability and active range of motion. they will be allocated through simple random sampling through sealed opaque envelopes into group a and group b. patients in dry needling (dn) group will receive a single session of dn with sterile needles insert on trigger points in scalene muscles as first twitch response will obtained needles will be manipulated in and out of the muscles to get 2 or 3 more local responses. patients in group b will receive a single session of ischemic compression technique for this ischemic compression technique sustained pressure on the trigger points will be maintained for 30 seconds. control treatment will be same for both groups. pre and post treatment values will be identified after one month follow-up.

Eligibility criteria:
inclusion criteria: * patients with scalene myofascial pain syndrome * age from 18 years to 45 * patients with positive scalene cramp test exclusion criteria: * whiplash injury * thoracic dysfunction any cervical radiculopathy * age below 18 and more than 45 years * any psychiatry disorder or * any contraindication to dry needling

Keywords: dry needing myofascial pain pain disability
coil embolization of coronary artery fistulas

Conditions: C14; C14907933; C14907933125; G09330582163324; C14280647250

Summary: background and purpose: congenital coronary artery fistula (caf) is an uncommon anomaly. in some patients they can became symptomatic, associated with significant morbidity and mortality. we report our experience in percutaneous treatment of caf.

congenital coronary artery fistula (caf) can be defined as a direct communication of a coronary artery with a cardiac chamber, great vessel, or other vascular structure, bypassing the myocardial capillary bed. caf is an uncommon anomaly, occurring as an incidental finding in 0.1% to 0.2% of coronary angiograms. they are not gender specific. many patients have symptoms like congestive heart failure, infective endocarditis, myocardial ischemia, or rupture of an aneurismal fistula. surgical closure of coronary artery fistula was initially reported in 1983 with low rates of morbidity and mortality. percutaneous treatment appeared as an alternative to surgery. transcatheter closure of caf was first utilized in 1983. along this years, with experience and improvements in catheterization equipment and occlusion devices, caf occlusion have been successfully performed using microcoils. we report our experience in using microcoils to percutaneous treatment of coronary fistulas.

Eligibility criteria:
inclusion criteria: * coronary artery fistulas * clinical diagnosis of angina, myocardial infarction, left ventricular insufficiency, ventricular enlargement exclusion criteria: * age \ 85 years * cardiogenic shock _ severe ventricular enlargement

Keywords: coronary fistulas. coils embolization.
speech in hepatic encephalopathy (he)

Conditions: Hepatic Encephalopathy

Summary: this is an observational study that will test the clinical significance of speech features in patients with cirrhosis. it aims to assess if speech is associated with cognitive function at baseline, if speech predicts changes in cognition, and if speech predicts future events of hepatic encephalopathy (cirrhosis-related confusion), as well as to assess the dynamics of speech over time, especially with episodes of overt hepatic encephalopathy (ohe) and treatment interventions.


Eligibility criteria:
inclusion criteria for patients with cirrhosis: * cirrhosis, as diagnosed by imaging, elastography, biopsy, or decompensation * able to provide informed consent in english exclusion criteria for patients with cirrhosis: * neurodegenerative disorder (other than hepatic encephalopathy) including alzheimer's disease and dementia * prior stroke or transischemic attack (tia) * english not primary language for communication inclusion criteria for patients without cirrhosis: * able to provide informed consent in english * fibroscan with stiffness \<7 kpa exclusion criteria for patients without cirrhosis: * alanine aminotransferase (alt) or aspartate aminotransferase (ast) \>5 times the upper limit of normal in the last year * history of cirrhosis by imaging or histology or clinical decompensation * neurodegenerative disorder (other than hepatic encephalopathy) including alzheimer's disease and dementia * prior stroke or tia
the effect of wearable vibration therapy on shoulder functionality in individuals receiving adjuvant radiotherapy after breast cancer surgery

Conditions: Breast Cancer

Summary: the aim of our study is to investigate the effect of vibration therapy to be applied to patients undergoing breast cancer surgery and adjuvant radiotherapy on upper extremity joint range of motion, muscle strength, grip strength, pain, functionality, and quality of life.


Eligibility criteria:
inclusion criteria: * diagnosed with breast cancer, undergoing breast-conserving surgery or having a total mastectomy and undergoing axillary lymph node dissection during surgery * cases that will start radiotherapy after surgery * being over 18 years old * absence of limitation in shoulder joint range of motion in preoperative evaluations. * no speech and hearing problems * volunteering of the patients included in the study exclusion criteria: * having previously undergone ipsilateral or contralateral breast cancer surgery * presence of active or metastatic cancer focus * presence of a neurological disease or orthopedic surgery affecting upper extremity functionality * carrying a pacemaker * presence of infection and open wound * finding a post-surgical drain * cases with mental and cooperation problems
activity monitoring in frail elderly patients

Conditions: Elderly

Summary: the purpose of this stuydy is to assess the bias and repeatability of the dynaport micromod in measuring movement / physical activity in frail elderly.

elderly subjects will be recruited from a residential-care complex in zwolle, the netherlands. all subjects will be asked to fill in the groningen frailty index. we aim to select patients with varying gfi scores to ensure that we include patients with different degrees of frailty. the participating subjects will be asked to wear the dynaport micromod during six hours. two research employees will observe all activities of the participating subjects in their home environment. the participant will be instructed to act like it is a normal/usual day. every 5 minutes the type of activity at that moment and movement intensity of the last 5 minutes (mets scale) is manually entered onto a case report form (crf) by the two employees. the timing has to be exact in order to compare the data to the data of the dynaport micromod. type of activity is described as well as categorised into lying, sitting, standing or walking. movement intensity is categorised according to a met-value (metabolic equivalent of task). sensitivity, specificity, and percentage of overall agreement will be calculated for each type of activity (standing, sitting, lying, walking) and for intensity. the primary analysis will be the comparison between walking and not walking (lying, sitting or standing). an overall agreement/sensitivity/specificity of 90% or higher is considered as sufficient agreement. the bland and altman method will also be used as multiple observations are recorded per patient, the limits of agreement will also be calculated with the bland and altman method for repeated measures.

Eligibility criteria:
inclusion criteria: * age: 75 years and older * frailty: gfi (groningen frailty index) score ≥ 4 exclusion criteria: * living in a nursing-home

Keywords: frailty accelerometry physical activity validity
delayed educational reminders in acute myocardial infarction (mi)

Conditions: Acute Myocardial Infarction; STEMI

Summary: st segment elevation myocardial infarction (stemi) is a common presentation of heart attack constituting approximately 30% of all cases. clinical guidelines around the world support the prolonged use of secondary preventative medications including aspirin, clopidogrel, statin, beta-blocker and angiotensin blockers with the highest recommendations. while in-hospital and discharge prescription rates are excellent, adherence to these essential life-saving medications is far less than ideal, even a few months following hospital discharge. the investigators plan to capitalize on the existing structure of the smart-ami project already underway in lhin iv to undertake a randomized controlled trial evaluating a reminder sent on behalf of the interventional cardiologists, delivered by mail, at 1, 2, 5, 8, and 11-months post-discharge, reviewing the evidence for life-saving cardiac medications and urging long-term adherence to secondary preventative cardiac medications. this will be sent to the family physician and the patient, using audience-appropriate language. if the derla-stemi project is accepted by physicians and patients, found to be both feasible and effective, then this simple and low-cost intervention will be studied in all patients with an abnormal coronary angiogram.


Eligibility criteria:
inclusion criteria: * admitted with stemi to a hospital in lhin iv, coronary angiogram with and without pci at hamilton general hospital during hospital admission exclusion criteria: * non-english speaking

Keywords: stemi medication adherence quality improvement
prospective feasibility study applying the acosog z0011 criteria to chinese patients

Conditions: Breast Cancer; Sentinel Lymph Node; Local Recurrence of Malignant Tumor of Breast

Summary: in patients undergoing breast-conserving surgery and having positive sentinel lymph nodes (slns), the acosog z0011 trial showed equivalent overall survival(os) and disease-free survival(dfs) outcomes for patients receiving sln dissection (slnd) alone and those receiving axillary lymph node dissection (alnd). we conducted a prospective single-arm study to confirm the applicability of the z0011 criteria to chinese patients with breast cancer.

the american college of surgeons oncology group (acosog) z0011 trial demonstrated that in clinically node-negative women with t1 or t2 invasive breast cancer, who underwent breast-conserving surgery (bct) with whole breast irradiation (wbrt), had excellent local control and survival with slnd alone, even if metastases were found in 1 or 2 slns. recently, the long-term follow-up data of the z0011 study were reported, which demonstrated that the 10-year os for patients receiving slnd alone was not inferior to that for those receiving alnd. this breakthrough result of the z0011 study led to a change in clinical practice regarding the standard management of axillary lymph nodes in patients with breast cancer. however, these validation data have been generated in western populations. as the socio-economic profile, life style and culture of asian are substantially different from those of western, and genetic backgrounds vary to some extent, it remains unclear whether results similar to those of the z0011 study could be achieved in a chinese breast cancer population. in the present study, we prospectively applied the z0011 eligibility criteria to chinese patients with clinically node-negative breast cancer undergoing bct, with planned rt. the purpose of this study is the clinicopathological relevance of the z0011 findings for chinese patients with breast cancer, and to verify the feasibility of using the z0011 criteria to avoid alnd after positive sln findings. this is a prospective single-arm study, enrolled patients meeting z0011 inclusion criteria and providing consent to receive no additional alnd. overall survival is the primary end point, disease-free survival and occurrence of surgical morbidities a secondary end point.

Eligibility criteria:
inclusion criteria: * histologically confirmed invasive breast cancer t1 or t2 tumor 1 or 2 positive sentinel lymph nodes breast-conserving surgery whole-breast rt planned exclusion criteria: * preoperative therapy 3 or more positive sentinel lymph nodes patients undergoing additional mastectomy due to positive surgical margins

Keywords: acosog z0011 chinese breast cancer sentinel lymph node overall survival disease-free survival
effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk

Conditions: Diabetes; Sleep Apnea

Summary: although obstructive sleep apnea (osa) is associated with impaired glucose tolerance and diabetes, it remains unclear whether osa treatment with continuous positive airway pressure (cpap) has metabolic benefits. the objective of this study is to determine the effect of 8-hour nightly cpap treatment on glucose metabolism in individuals with prediabetes and osa.

although obstructive sleep apnea (osa) is associated with impaired glucose tolerance and diabetes, it remains unclear whether osa treatment with continuous positive airway pressure (cpap) has metabolic benefits. to determine the effect of 8-hour nightly cpap treatment on glucose metabolism in individuals with prediabetes and osa. in a randomized, controlled parallel group study, 39 participants were randomized (2:1) to receive either 8-hour nightly cpap (n=26) or oral placebo (n=13). sleep was polysomnographically recorded in the laboratory on each night. cpap adherence was ensured by continuous supervision. participants continued their daily daytime routine activities outside the laboratory. glucose metabolism was assessed at baseline and after 2-weeks of assigned treatment using both the oral and intravenous glucose tolerance tests (ogtt and ivgtt, respectively). the primary outcome was the overall glucose response as quantified by the area under the curve for glucose during 2-hour oral glucose tolerance testing.

Eligibility criteria:
inclusion criteria: * overweight or obese adults (age ≥45 yrs and bmi ≥25 kg/m2) * prediabetes and osa (ahi ≥ 5) * regular life styles and schedules (no shift work in the past 6 months, no travel across time zones during the past 4 weeks) * habitual bedtimes of at least 6 hours but not exceeding 9 hours will be eligible. * not to take any medications during the study period with the exception of antihypertensives and lipid lowering agents * not on hormone replacement therapy. * have sedentary activities and no competitive athletes or subjects with high exercise levels. exclusion criteria: * previous or current treatment with supplemental oxygen * requirement of supplemental oxygen or bi-level positive airway pressure for osa treatment during titration * presence of active infection, psychiatric disease or history of other significant illness (e.g., myocardial infarction, congestive heart failure, stroke, arrhythmia, chronic kidney or liver disease0 * clinical depression as evidenced by a score \>16 in ces-d scale * smoking, or routine alcohol use (more than 2 drinks per day), or excessive caffeine intake (\>300mg per day)

Keywords: cpap diabetes sleep apnea
effects of isotretinoin on the growth rate and thickness of the nail plate

Conditions: Isotretinoin; Nail Abnormality

Summary: the nail is an important skin appendage which can provide information about the person's overall health status in addition to having several important functions such as protection, tactile sensation, grasping. many nail abnormalities which can have considerable psychological impact are side effects of drug administration. retinoids have various effects on nails. although isotretinoin as a retinoid has been associated with both decreased and increased nail growth, the great majority of such associations are not evidence-based. so, it was aimed to investigate the effects of isotretinoin on morphology, growth rate, and thickness of the nail plate.

isotretinoin has various side effects that affect many organ systems. some side effects such as nail changes, which do not require treatment cessation, can limit the use of isotretinoin by impairing the patient's quality of life. although it is known that isotretinoin has various effects on the nails, there is very limited data on effects of isotretinoin on the nails. therefore, it was aimed to investigate the effect of isotretinoin on the morphology, growth rate, and thickness of the nail plate. the patients aged 18-45 that were planned to begin treatment with isotretinoin for acne in the outpatient clinic and a control group consisting of healthy volunteers are planned to be included in the study. a dermatological examination of skin and nails is conducted in all participants. isotretinoin treatment at 0.5 mg/kg per day in 2 divided doses will be started to patients with acne. the length and thickness of nail plate are measured by digital caliper before isotretinoin treatment, and repeated during the control visits of the participants at 30 day intervals for 6 months. all the examination and measurements are carried out in both groups.

Eligibility criteria:
inclusion criteria: * the patients that were planned to begin treatment with isotretinoin for acne exclusion criteria: * having known diseases (dermatological or systemic disorders) affecting the growth rate and thickness of nail plate * using systemic or topical drugs with known effects on nail * having traumatic nail abnormalities (onychotillomania, nail biting, habit-tic deformity) * having no visible lunula * describing any trauma (including cutting or filing nails) between the two measurements

Keywords: isotretinoin nail growth rate nail thickness 13-cis-retinoic acid
phase i/ii randomized, placebo-controlled study of capsaicin for interstitial cystitis and vulvar vestibulitis

Conditions: Interstitial Cystitis; Vulvar Diseases

Summary: objectives: i. estimate the optimal safe dose of intravesical capsaicin in patients with interstitial cystitis. ii. evaluate the efficacy of 0.025% topical capsaicin in relieving chronic burning pain in patients with vulvar vestibulitis. iii. evaluate the effect of capsaicin on type c nerve fibers in bladder mucosa and vulvar skin. iv. evaluate the effect of c fiber depletion on urinary levels of histamine and prostaglandin.

protocol outline: this is a randomized study. patients with interstitial cystitis are randomly assigned to 1 of 3 pain control therapies. the first group is treated with capsaicin. a second group is given individually titrated doses of capsaicin: the dose is increased as tolerated or until symptomatic response is acceptable. a control group receives a placebo. therapy for all groups is administered intravesically every week for 5 weeks. patients with vulvar vestibulitis are randomly assigned to 1 of 2 pain control therapies. one group applies topical capsaicin cream to the painful area 4 times a day for 6 weeks. the dose is individually titrated if burning discomfort persists and the patient is compliant with the application schedule. the control group applies a placebo. patients with vulvar vestibulitis may continue or cross to capsaicin for 6 additional weeks.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- women with interstitial cystitis by national institute of diabetes and digestive and kidney diseases criteria vulvar vestibulitis by international society for the study of vulvar disease, i.e.: severe pain on touch or attempted entry of vagina tenderness to pressure within the vulvar vestibule vulvar erythema duration of symptoms at least 6 months absence of vulvovaginal infection, i.e.: no fungus no trichomonas no chlamydia no gonorrhea no "clue cells" in vaginal discharge

Keywords: interstitial cystitis rare disease renal and genitourinary disorders vulvar vestibulitis
pilot study in order to evaluate disconfort among outpatients using actitens for neuropathic pain vs tens eco 2.

Conditions: Neuropathic Pain

Summary: non-pharmacological treatments for pain relief are more and more used in clinical care although any scientific validation. among the non-pharmacological treatments of neuropathic pain relief, tens (electrical nerve stimulation therapy) is the major treatment with the best benefit. unfortunately, the use of tens by patients appears very difficult. because of this inconvenience, more than 40% of tens users interrupt the treatment despite treatment benefit. a new tens device: actitens that seems to be less constraining than tens is now available in france. actitens efficacy and safety compared to tens need to be investigated. the main objective is to evaluate and to compare the use of actitens, with tens eco 2, the classical device in patients with chronic neuropathic pain.


Eligibility criteria:
inclusion criteria: * adult * patient covered by national health insurance * patient able to express consent * patient with neuropathic pain with dn4 (douleur neuropathique 4 questions) \> or = 4/10. * actual or potential neurologic lesion * patient still using a tens device exclusion criteria: * planned surgery in the next two months * modification of the reatment in the next two motnhs * other study ongoing for the patient * medical contraindication for tens

Keywords: neuropathic pain electrical nerve stimulation therapy patient report outcomes non-pharmalogical treatment
the effect of attention bias modification training on reducing depressive symptoms

Conditions: Depressive Symptoms

Summary: the purpose of this study is to test whether attention bias modification training is an effective neurobehavioral therapy to improve depressive symptoms.that is whether attention bias modification training is superior to placebo in reducing depressive symptoms over 1 year after training.

attentional bias has been theorized to play a critical role in the onset and maintenance of depression. attentional bias modification training (abmt), an experimental paradigm that uses training to induce adaptive attentional bias, was developed to test the causal model and this has therapeutic implications in depression.to test the effect of abmt on treatment of depressive symptoms, a randomized, double-blind, placebo and blank controlled trial is conducted in college students who are experiencing mild-to-severe symptoms of depression.

Eligibility criteria:
inclusion criteria: * a score of 14 or higher on the beck depression inventory-ii exclusion criteria : 1. a current episode of mdd, bipolar disorder, schizophrenia or organic mental disorder; 2. any concurrent psychotherapy; 3. any concurrent psychotropic medication.

Keywords: depression attention training modification