Kornimate/medical-research-clean huggingface dataset:
under-represented communities diagnosed with scd or mci through tele-cog

Conditions: Mild Cognitive Impairment; Subjective Cognitive Decline

Summary: overall, this study's primary aim is to establish a prospective, longitudinal, observational cohort study of older adults at risk for dementia from under-resourced/underrepresented communities. more specifically, older adults diagnosed with subjective cognitive decline (scd) or mild cognitive impairment (mci) during clinical care offered via the tele-cog clinic would be recruited for more comprehensive data collection to characterize the clinical presentation and course of illness over multiple timepoints spread out longitudinally.

clinical data obtained as part of standard of care will be collected from the medical record (including clinical diagnosis, cognitive and other neuropsychological test scores, lab results, neuroimaging data, etc.) and additional data (neuropsychological test batteries and clinical questionnaires if not already obtained) would be obtained at research study visits. participants will be asked to participate in annual research visits for up to 5 years.

Eligibility criteria:
inclusion criteria: 1. adults ages 50 years and older 2. diagnosed with subjective cognitive concerns (scd) or objective cognitive decline with mostly intact functioning (mci diagnosis) as part of clinical work up 3. fluent in english 4. able to provide voluntary informed consent 5. willing and able to undergo all study procedures 6. able to delegate, if possible, a study partner to contribute information regarding daily activities and cognition exclusion criteria: 1. diagnosis of dementia at baseline. 2. inability to give informed consent. 3. high risk of adverse emotional or behavioral reaction based on investigator's clinical evaluation (e.g., evidence of serious personality disorder, antisocial behavior, serious current stressors, lack of meaningful social support).
prevent - prospective rhythm event surveillance in the er with netguard

Conditions: Cardiac Event

Summary: the purpose of this study is to determine the incidence of clinically significant rhythm and rate changes in ed patients who are not placed on conventional telemetry, and to test the user-friendliness of a automated clinician alter device in hectic and noisy setting of a busy emergency room.


Eligibility criteria:
inclusion criteria: * \> 18 yes * agree to participate in study * telemetry not indicated * telemetry not available * willingness to complete a questionnaire- exclusion criteria: * refusal to participate * know sensitivity to adhesive * language/communication barriers * perceived high risk for lack of study compliance

Keywords: cardiac rhythm changes
a retrospective chart review of botox® and xeomin® for the management of cervical dystonia and blepharospasm

Conditions: Cervical Dystonia; Blepharospasm

Summary: this study is a retrospective chart review to evaluate the doses of botulinum type a toxins botox® (onabotulinumtoxina) and xeomin® (incobotulinumtoxina) used for the treatment of cervical dystonia and blepharospasm in clinical practice.


Eligibility criteria:
inclusion criteria: * confirmed primary diagnosis of idiopathic cervical dystonia or blepharospasm for at least 2 years * treatment with xeomin® and botox® for at least 2 years each. exclusion criteria: * having a neuromuscular junction transmission disorder or taking any medications that could affect neuromuscular junction transmission * previous surgical procedure involving bone or muscle for the management of cervical dystonia or blepharospasm.
prediction of the pronounce prostate cancer trial in healthcare claims data

Conditions: Prostate Cancer

Summary: investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials. the investigators' goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies.

this is a non-randomized, non-interventional study that is part of the rct duplicate initiative (www.rctduplicate.org) of the brigham and women's hospital, harvard medical school. it is intended to replicate, as closely as is possible in healthcare insurance claims data, the trial listed below/above. although many features of the trial cannot be directly replicated in healthcare claims, key design features, including outcomes, exposures, and inclusion/exclusion criteria, were selected to proxy those features from the trial. randomization is also not replicable in healthcare claims data but was proxied through a statistical balancing of measured covariates according to standard practice. investigators assume that the rct provides the reference standard treatment effect estimate and that failure to replicate rct findings is indicative of the inadequacy of the healthcare claims data for replication for a range of possible reasons and does not provide information on the validity of the original rct finding.

Eligibility criteria:
please see https://drive.google.com/drive/folders/1wd618wrywyjeaxzfltcuk-vccnb6b-gv for full code and algorithm definitions. eligible cohort entry dates: the degarelix indication for treatment of prostate cancer was approved by the fda on dec 24, 2008. leuprolide was initially approved for the same indication prior to dec 24, 2008. ibm marketscan: dec 24, 2008 - december 31, 2018 (end of available data) optum cdm: dec 24, 2008 - june 30, 2020 (end of available data) cms diabetes: dec 24, 2008 - dec 31, 2017 (end of available data) inclusion criteria: * histologically confirmed adenocarcinoma of the prostate * pre-existing ascvd (confirmed diagnosis, documented) according to a least 1 of the following criteria: * previous mi \>= 30 days before randomization * previous revascularization procedure \>= 30 days before randomization * coronary artery: stent placement/balloon angioplasty or coronary artery bypass graft surgery * carotid artery: stent placement/balloon angioplasty or endarterectomy surgery * iliac, femoral, popliteal arteries: stent placement/balloon angioplasty or vascular bypass surgery exclusion criteria: * treatment naivety (adt) * previous or current hormonal management of prostate cancer including surgical castration, any hormonal manipulation, or any previous neoadjuvant/adjuvant hormonal therapy, unless treatment was terminated more than 12 months prior to enrollment * uncontrolled type 1 or type 2 diabetes mellitus * uncontrolled hypertension * a history of congenital long qt syndrome or risk factors for torsade de pointes ventricular arrhythmias * mi; stroke; or coronary, carotid, or peripheral artery revascularization
evaluation of immunonutrition for patients with pneumonia in the intensive care unit.

Conditions: Nutrition Poor

Summary: the aim of the work will be to assess the combined effect of enteral or parenteral nutrition enriched with immunonutrition on the outcome of critically ill patients with pneumonia in comparison with patients who received standard care of nutrition in intensive care unit.

pneumonia is defined as an infection process of the lung parenchyma, which results from the invasion and overgrowth of microorganisms, breaking down defences, and provoking intra-alveolar exudates. patients with pneumonia become malnourished ,exhibit declining health and changes in weight loss, and impair respiratory muscle contractility. adequate nutrition aids respiratory muscle function and immune defence mechanisms. therefore, the major role of nutrition in pneumonia is reducing malnutrition that induces high mortality and morbidity and maintaining impaired respiratory muscle contractility. pulmonary failure is associated with increased catabolism and decreased gut absorption. if respiratory failure require mechanical ventilation or patient need non-invasive ventilation. the presence of an artificial airway prevents volitional nutrition intake, leading to an energy deficit, the underlying process leading to respiratory failure may induce protein catabolism, causing loss of diaphragmatic and intercostal muscle mass, impairing immunity, impairing wound healing, and increasing the risk for new infection. nutrition support also protects patients by minimizing malnutrition and loss of lean body mass. immunonutrition refers to modulation of the immune system provided by specific interventions that modify dietary nutrients. several specialized enteral and parenteral formulas with immunonutrients are currently available on the market. these primarily consist of a combination of antioxidant vitamins (eg, vitamin c, vitamin e, ß-carotene), trace elements (eg, selenium, zinc), essential amino acids (eg, glutamine, arginine)or essential fatty acids, such as omega-3 fatty acids (eg, eicosapentaenoic acid, docosahexaenoic acid), and ƴ-linolenic acid.

Eligibility criteria:
inclusion criteria: * patients ( \>18 years) with pneumonia requiring ventilatory support either invasive mechanical ventilation or non-invasive ventilation and could be enterally or parenterally fed in the respiratory intensive care unit of assiut university hospitals. a diagnosis of pneumonia will be made based on clinical data and laboratory investigation. radiological confirmation of the diagnosis will be done. patients will assess using the simplified acute physiology score (saps ii) system (4). also we will use nutric score. exclusion criteria: * age less than 18 years old. * patients with immunosuppressive and malignant tumours. .patients with severe liver and kidney disease.
robotic radical cystectomy outcomes

Conditions: Bladder Cancer; Muscle-Invasive Bladder Carcinoma; Oncology; Recurrence; Surgery

Summary: currently, in the treatment of bladder cancer the use of robotics has entered in clinical practice, therefor robotic radical cystectomy with or without reconstruction is offered to patients during counseling procedures, if deemed appropriate and possible. the aim of the study is therefore the long-term evaluation of the peri-post-operative, oncological and functional results of patients undergoing radical cystectomy, both with an open and robotic approach. this study will thus help to clarify the actual impact of robotic surgery


Eligibility criteria:
inclusion criteria: * age major or equal 18 years * patients who will undergo radical cystectomy * consent to participate exclusion criteria: * absence of willingness to participate * further refusal to participate to the study

Keywords: cystectomy radical cystectomy ileal conduit neobladder bladder cancer muscle invasive bladder cancer
khalifa effectiveness study

Conditions: Total Rupture of the Anterior Cruciate Ligament in the Knee

Summary: the primary hypothesis is that khalifa's therapy brings additional benefit compared to standard therapy (physiotherapy) for patients with a ruptured anterior cruciate ligament (acl).

mohamed khalifa, a therapist from hallein (austria), has been working since 30 years with a self-developed manual technique for treating injuries of the musculoskeletal system especially of the knee by applying high pressure to the skin in the area of the injury. this pressure is applied in various amplitudes and frequencies. international top athletes from various disciplines reported a rapid pain relief, and even full recovery, immediately after his one hour treatment. prior to the investigators' study, the investigators evaluated one pilot patient with a complete acl rupture after a soccer game with magnet-resonance-imaging (mri) and clinical tests. this patient was physically immobile and reported pain especially when stretching and bending the knee. after one hour of treatment from khalifa the signs of the injury like the stretching / bending inhibition and pain were gone immediately. three months after the treatment, an evaluation of the knee with mri showed an end-to-end continuous acl with homogeneous signal and the clinical tests confirmed the stability of the knee. with this study the investigators will evaluate the possibility of influencing the healing of a completely ruptured acl of the knee by one single special local pressure treatment to the skin for 60 min.

Eligibility criteria:
inclusion criteria: * totally ruptured acl - mri verified, 4 weeks old as a maximum * knee function: any functional inhibition (stretching, bending or load) * bmi: 18-28 * athletically active exclusion criteria: * any surgical procedures at the injured knee at any previous time * any acute surgical indication * diabetes mellitus and/or high blood pressure * any permanent drug treatment

Keywords: acl ligament knee
adverse drug reactions to cancer therapies in patients with depression: insights from vigibase

Conditions: Adverse Effects of Medical Drugs

Summary: importance: depression is prevalent among oncology patients and may influence the perception, reporting, and severity of adverse events (aes) related to cancer therapies. understanding this association is crucial for optimizing treatment outcomes and improving patient quality of life. objective: to evaluate the association between depression and the reporting and severity of aes among oncology patients using data from vigibase®, the world health organization's global pharmacovigilance database. design: this pharmacovigilance study employed a case/non-case disproportionality analysis using individual case safety reports (icsrs) from 1968 to 2024. multivariable analyses were conducted to adjust for potential confounders, such as age and sex. setting: the study utilized data from vigibase®, a global pharmacovigilance database containing reports from over 120 countries. participants: icsrs involving antineoplastic or immunomodulating agents were included. depression was identified through antidepressant use, yielding 428,102 reports for patients on antidepressants and 8,376,761 for those not on antidepressants. exposure: oncology patients receiving antidepressant therapy were compared to those not receiving such treatment. main outcome and measures: the primary outcome was the reporting of serious aes (e.g., hospitalization, life-threatening events). secondary outcomes included the 20 most frequently reported aes among oncology patients, with comparisons made between those treated with and without antidepressants.


Eligibility criteria:
inclusion criteria: * icsrs were limited to those involving liable antineoplastic or immunomodulating agents (per the anatomical therapeutic chemical (atc) classification code l; hereafter referred to as antineoplastics) exclusion criteria: * suspect of duplication

Keywords: adverse effects oncology vigibase
hypersensitivity reaction to vitrase (ovine hyaluronidase)

Conditions: Drug Hypersensitivity

Summary: the objective of this study was to rule out a greater than 10% incidence of hypersensitivity to vitrase following a single intradermal injection of 3 usp units vitrase. less than or equal to a 10% hypersensitivity response was considered acceptable.


Eligibility criteria:
inclusion criteria: * agreed to avoid disallowed meds exclusion criteria: * known hypersensitivity to hyaluronidase and/or bee sting * previous known exposure to ovine hyaluronidase or bovine hyaluronidase * atopic individuals assessed by medical history * topical/inhaled/systemic corticosteroids within 30 days * concurrent use of antihistamines or anti-inflammatory during study * active or chronic disease likely to affect immune function * history of alcohol/drug abuse within 6 months
a study of lanabecestat (ly3314814) in early alzheimer's disease dementia

Conditions: Alzheimer's Disease

Summary: this study is an extension of study i8d-mc-azes (nct02245737), the amaranth study. the purpose of this study is to evaluate the effectiveness of the study drug lanabecestat in participants with early alzheimer's disease dementia at the time of entry into study i8d-mc-azes.

study azfd was designed to be integrated with 104-week study azes to form a delayed-start study (study azes-fd). study azes-fd was to be used to test the hypothesis that participants originally randomized to receive placebo in the double-blind feeder study azes and switched to ly3314814 at the start of study azfd did not "catch up" on the alzheimer's disease assessment scale-cognitive subscale (adas-cog13) at week 26 of study azfd to participants originally randomized to receive ly3314814 in the double-blind feeder study.

Eligibility criteria:
inclusion criteria: * participants previously enrolled in amaranth (nct02245737) who meet eligibility criteria for delayed-start i8d-mc-azfd. exclusion criteria: * participants who participate in amaranth (nct02245737) who develop new conditions precluding them from enrolling into i8d-mc-azfd.

Keywords: alzheimer's disease dementia brain diseases neurodegenerative diseases central nervous system diseases nervous system diseases mental disorders delirium, dementia, amnestic, cognitive disorders tauopathies memory amyloid
a prospective cohort study on the comorbid depression in patients with newly-diagnosed epilepsy

Conditions: Epilepsy

Summary: epilepsy is a chronic brain disease with recurrent seizures and the comorbidity of psychiatric diseases are very common. the prevalence of depression in patients with refractory epilepsy is about 60%. however, the early diagnosis is usually difficult due to the unclear mechanism and untypical clinical symptoms, and there are no extremely effective treatments for depression in patients with epilepsy until now. in this prospective, multi-center, cohort study, we aim to investigate and screen two different types of depression ("cognitive" and "somatic") in patients with epilepsy by using the combination of regular moods evaluating scales and heart rate variability instrument. the intervening methods of combining transcranial direct current stimulation (tdcs) and serotonin re-uptake inhibitors (ssris) are used to treat the patients with comorbidity of epilepsy and depression.

epilepsy is a chronic brain disease with recurrent seizures and the comorbidity of psychiatric diseases are very common. the prevalence of depression in patients with refractory epilepsy is about 60%. however, the early diagnosis is usually difficult due to the unclear mechanism and untypical clinical symptoms, and there are no extremely effective treatments for depression in patients with epilepsy until now. in this prospective, multi-center, cohort study, we aim to investigate and screen two different types of depression ("cognitive" and "somatic") in patients with epilepsy by using the combination of regular moods evaluating scales and heart rate variability instrument. the intervening methods of combining transcranial direct current stimulation (tdcs) and serotonin re-uptake inhibitors (ssris) are used to treat the patients with comorbidity of epilepsy and depression. and resting-state functional mri will be conducted in patients with the comorbidity of epilepsy and depression before and after the combing treatment of tdcs and ssris.

Eligibility criteria:
inclusion criteria: * meeting the definition of epilepsy according to the new definition issued by ilae in 2014 * not using antidepressants * acquiring informed consents exclusion criteria: * patients with severe psychiatric symptoms; * progressive brain diseases * malignant tumors * severe cognitive declines
augmented reality feasibility for non-invasive preoperative tracking in breast cancer surgery

Conditions: Subclinical Breast Cancer Lesion

Summary: breast cancer is diagnosed by imaging at a non-palpable stage in more than half of all cases. surgical removal requires preoperative guidance. generally, preoperative guidance is performed using a metal guide under local anaesthetic and radiological control. this type of guidance has several limitations. for the patient, it can be painful and traumatic. the procedure involves two departments: radiology and the operating theatre, which poses logistical constraints. what's more, between 10% and 40% of patients require repeat surgery for unhealthy margins, raising the question of the effectiveness of the tracking procedure. the investigators propose to develop a non-invasive intraoperative guidance system: augmented reality, which will provide a 3d vision with virtual transparency of the breast during surgery, thanks to real-time fusion of preoperative imaging with video from a camera located in the operating room. the process is illustrated below. illustration of the general principle of the augmented reality system for locating non-palpable breast lesions. the images above represent a preliminary test carried out on the computer outside the operating room. this is an initial research prototype which has not yet been validated and is not suitable for routine use.


Eligibility criteria:
inclusion criteria: * major women * requiring conservative surgical management of a subclinical cancerous breast lesion (not palpable), the histology of which has been previously proven by anatomopathology; * having a breast mri indication at the time of the breast assessment performed at the centre jean perrin * ability to give informed consent to participate in the study, * membership of a social security scheme exclusion criteria: * patients with breast neoplasia during pregnancy; * persons deprived of their liberty or under guardianship or incapable of giving consent; * refusal to participate.
outcome of laser or debrider tonsillotomy versus tonsillectomy in obstructive sleep apnea

Conditions: Obstructive Sleep Apnea

Summary: tonsil surgery for children suffering from obstructive sleep apnea have significant post operative morbidity including pain and occasionally bleeding. this morbidity is partly caused by post surgical inflammation. this inflammatory process can be quantified using various proinflammatory cytokines. the goal of this study is to objectively compare the inflammatory process after treatment of obstructive sleep apnea with different surgical approaches to the enlarged tonsils.

tonsil surgery for children suffering from obstructive sleep apnea have significant post operative morbidity including pain and occasionally bleeding. this morbidity is partly caused by post surgical inflammation. this inflammatory process can be quantified using various proinflammatory cytokines. the goal of this study is to objectively compare the inflammatory process after treatment of obstructive sleep apnea with different surgical approaches to the enlarged tonsils. in the study three approaches are prospectively compared: 1. tonsillectomy - using electrocautery resecting all tonsillar tissue. 2. debrider tonsillotomy - reducing the tonsillar tissue with a debrider. 3. laser tonsillotomy - reducing tonsillar tissue using a co2 laser. all patients will be randomized to one of three arms. each arm will include 25 children. all children will have a preoperative and postoperative sleep study. questioners assessing pain, amount of medication used to control pain and sleep disturbance during the first 7 days after surgery will be filled by the child caretaker. blood will be drawn immediately before surgery and 18-24 hours after surgery. the following blood products will be assessed: white blood cells, clotting factors, c reactive protein, il1 beta,tnf alpha, il6, il2. if the study will show objectively and subjectively that partial resection of the tonsil compared to complete tonsillectomy is less painful and has less postoperative inflammation.

Eligibility criteria:
inclusion criteria: age 2-16 obstructive sleep apnea ahi\>5 hypertrophy of tonsils and adenoids - exclusion criteria: children with recurrent tonsillitis craniofacial anomalies neuromuscular disease down syndrome

Keywords: obstructive sleep apnea tonsillectomy tonsillotomy inflammation pain post tonsillectomy bleeding