Kornimate/medical-research-clean huggingface dataset:
long term neurocognitive effects of low-dose radiation in the brain: study of 150 patients in the french hemangioma cohort

Conditions: Patients Treated by Radiotherapy with < One Gy to the Brain

Summary: context: studies that address specifically the neurocognitive consequences that can be caused by low-dose radiation receiving during the childhood have still to be performed. in this issue, we focus on an investigation with patients who have received radiotherapy for a benign tumor (skin hemangioma), in france. patients and methods: more than 8300 children with a skin hemangioma were treated at gustave roussy (île-de-france) from 1941 to 1973 and a number of them have received radiotherapy. these patients have been treated and followed by gustave roussy, so their clinical records can be tracked with great accuracy and the ionizing radiation dose to the brain have been estimated. from this patient cohort, the aim is to evaluate neurocognitive dysfunction or disorder that can be caused by low-dose radiation to the brain (less than one gray (gy)). a total of 150 patients is expected. they will be contacted by letter to explain the purpose and methods of carrying out tests. two groups will be analysed according to the received ionizing radiation dose to the brain during the radiotherapy (exposed: 0.05 to 1 gy, vs unexposed: less than 0.05 gy). tests exploring several cognitive functions (memory, arithmetic, orientation, etc.) will be used. expected results: we expect to describe the potential neurocognitive dysfunction or disorder and to identify risk factors and brain structures whose lesions are responsible for the neurocognitive dysfunction or disorder. a therapeutic treatment will be proposed in the eventuality of screening of a neurocognitive dysfunction or disorder.

cograd is an interventional study designed within the european project called cognitive and cerebrovascular effects induced by low dose ionizing radiation (cerebrad). cerebrad is a collaborative european project funded in 2011 within the 7th european union (eu) framework programme, nuclear fission and radiation protection. cerebrad aims to identify the potential cognitive and cerebrovascular risks of radiation doses below 100 milligray (mgy) when delivered to a young child (pre- or postnatally).

Eligibility criteria:
inclusion criteria: * subject treated by radiotherapy for a skin hemangioma in childhood at gustave roussy between 1941 and 1973 and who have received less than 1 gy of radiation doses in the brain * inhabitants of île-de-france * french medical insurance * good knowledge and understanding of the french language non-inclusion criteria * cerebral hemangioma * syndrome genetic predisposition * pregnant woman * private person of liberty or under guardianship * radiation dose to the brain greater than 1 gy during radiotherapy treatment of skin hemangioma * chemotherapy during skin hemangioma treatment * inability to undergo counseling for geographical reasons exclusion criteria: * pregnancy * inability to perform neurocognitive tests battery for medical reasons
neurolex eeg-based adhd assessment aid, pivotal study

Conditions: Attention Deficit Disorder With Hyperactivity

Summary: the study will evaluate the effectiveness of a standardized eeg method with the intended clinical users in the intended clinical settings with the intended population (patients who would typically receive a clinician's evaluation for adhd). multiple sites will be examined to provide a sample of patients across numerous communities with different demographics. the goal is to evaluate if the predictive accuracy of eeg will not be inferior to that of a widely-used and extensively validated adhd scale in the prediction of adhd in the intended use population as evaluated by best estimate diagnosis.


Eligibility criteria:
inclusion criteria: * subject willing to voluntarily participate in a research study that includes eeg collection and analysis. * family/patient seeking comprehensive clinical evaluation for attention and/or behavior concerns. * male or female at least 6 years of age and who will not be over 17.99 years of age upon admission to study. * willing to stop any and all current psychiatric medications prior to or by entry into study. * subject and parent (or legal representative) of an educational level and degree of understanding sufficient to communicate suitably with the investigator, rater and study coordinator. exclusion criteria: * previous diagnosis of mental retardation. iq \< 70 by previous records. * history of seizure disorder or of eeg abnormalities. on anticonvulsants for seizure control. * metal plate or metal device in the head. * suicide ideation or gesture and/or homicidal ideation or gesture. * concomitant medications during participation in a research study. no prescription or nonprescription medications with psychoactive properties that may affect eeg (such as over-the-counter dietary supplements, pseudoephedrine, or phenylpropanolamine). no antipsychotics, no psychostimulants, no antidepressants. washout of at least one week or longer depending on the medication and clinician's judgment. medication used for medical reasons must be cleared by research staff with consideration of known effects on eeg. * known serious medical problems (cardiovascular, hematological, liver, seizure disorder, renal, or chronic respiratory problems).

Keywords: adhd, attention deficit hyperactivity disorder
steristrips adhesive tape versus subcuticular suture for episiotomy repair in primigravid obese women

Conditions: Episiotomy Wound

Summary: this study will be done to question the superiority of using skin adhesive tape (® steri-strip) closure in wound pain and healing over the traditional running absorbable subcuticular suture technique in perineal repair after episiotomy in obese primiparous women..

episiotomy is the most common operating procedure that most obstetricians will perform in their lifetime. because it is so common and considered minor surgery, teaching students or interns the principles and techniques usually is left to the most junior of residents the optimal method for episiotomy and perineal trauma repair following childbirth remains open to debate and a great cause of concern to doctors, midwives, and the public apparently, the ideal method for perineal repair should be quick, painless, easy to perform and preferably, without an increase in pain and dyspareunia during the puerperium this study will be commenced to question the advantage of using skin adhesive tape (® steri-strip) closure in wound pain and healing over the traditional running absorbable subcuticular suture technique in perineal repair after episiotomy in obese primiparous women.

Eligibility criteria:
inclusion criteria: * primigravidae 18 years or older. * spontaneous not induced full term normal not instrumental vaginal delivery with mediolateral episiotomy. * first and 2nd-degree perineal tear. * bmi≥30 exclusion criteria: * • patients who had an instrumental delivery. * 3rd and fourth-degree perineal tears. * those with local infectious lesions in the area to be repaired. * preexisting medical disorders as diabetes mellitus, severe pulmonary disease and collagen disease. * immunosuppressive treatment. * known hypersensitivity to adhesive tape or materials. * maternal unwillingness to undergo randomization.
transnasal humidified rapid insufflation system for intubation

Conditions: Hypoxemia

Summary: transnasal humidified rapid insufflation ventilator exchange (thrive) or not during the anesthesia induction

control group-usual mask ventilation during apnea for anesthetic intubation and check tube positioning thrive group-applying thrive during apnea for anesthetic intubation and check tube positioning

Eligibility criteria:
inclusion criteria: * patients who scheduled for elective lung surery with one lung ventilation exclusion criteria: * suspicious difficult intubation (bmi \>35kg/m2, mouth opening \ 3), room air spo2 \< 90%, active pulmonary infection, emergency operation, pregnancy
effect of vitamin c on postoperative pain after laparoscopic cholecystectomy

Conditions: Chronic Cholecystitis; Cholelithiasis

Summary: the aim of this study is to evaluate the effect of vitamine c supplements to be helpful to reduce the postoperative pain after laparoscopic cholecystectomy through the double-blinded randomized controlled trial.

the aim of this study is to evaluate the effect of vitamine c supplements to be helpful to reduce the postoperative pain after laparoscopic cholecystectomy through the double-blinded randomized controlled trial. the primary purpose of this study is to confirm the reduce of postoperative pain through the oral supplement of vitamine c before and after the surgery. for this purpose, we compared the dosage or counts of opioids usage with the oral supplement of vitamine c or not. the secondary purpose is to assess the pain score, postoperative morbidities, postoperative length of stay or postoperative time between two groups.

Eligibility criteria:
inclusion criteria: * chronic cholecystitis * gallbladder polyp exclusion criteria: * grade i tokyo guideline for acute cholecystitis * grade ii tokyo guideline for acute cholecystitis without the evidence of gallbladder perforation * gallbladder cancer * the patient who underwent reduced port surgery * the patient who underwent common bile duct exploration during the operation * the patient who underwent concurrent operation * the patient who had past history of upper abdominal surgery * the patient who had a immunodeficiency state * the case which had a suspicion of delayed bile leakage * the case which had a incomplete cystic duct ligation * the patient who underwent open conversion surgery during the operation * the patient who had a high risk of bleeding
the effect of ultrasound real-time guidance technique on the effectiveness and safety of labor analgesia

Conditions: Labor Analgesia

Summary: ultrasound real-time guidance technology has great advantages over traditional blind exploration technology in terms of accuracy, success rate, and reduction of puncture damage in intervertebral space positioning through operational visualization, greatly improving the effectiveness and safety of spinal block. at present, doppler ultrasound is rarely used for spinal block, especially for real-time ultrasound guidance technology, which has not been widely applied in clinical practice due to its high equipment requirements, lack of mature puncture plans, complex operation, and high learning curve. if a comprehensive diagnosis and treatment plan can be developed, it will greatly improve the delivery experience of mothers.

traditional blind exploration of spinal canal puncture has many limitations, often forcing changes in anesthesia methods due to multiple puncture failures. however, the application of real-time ultrasound guidance technology in spinal canal puncture can completely solve this clinical difficulty. the ultrasound-guided real-time paramedian approach epidural puncture for labor analgesia is a new type of labor analgesia technology, and its specific operating standards and diagnostic and treatment routines have not yet been established, including the selection of puncture path, puncture needle model, distance between puncture hole and epidural injection point, drug type, dosage, solubility, volume and other parameters, all of which have great research space.

Eligibility criteria:
inclusion criteria: 1. american society of anesthesiologists (asa) class i or ii; 2. single healthy pregnancy; 3. head showing first; 4. 37 to 41 weeks; 5. the labor process is active, and the cervix dilates\<5cm; 6. require epidural labor analgesia; 7. volunteer to participate in this study and sign an informed consent form. exclusion criteria: 1. presence of pregnancy diseases, such as pregnancy hypertension, pre eclampsia, pregnancy diabetes; 2. contraindications to intraspinal analgesia: 1) central nervous system diseases. 2) infection or septicemia at the puncture site. 3) coagulation dysfunction; 3. known cases of fetal malformation or increased risk of cesarean section, such as a history of uterine rupture; 4. persons with a history of mental illness, hysteria, epilepsy, etc. who cannot cooperate. 5. patients with long-term use of opioids, steroids, and chronic pain.

Keywords: ultrasound real-time guidance labor analgesia delivery woman neonate effectiveness safety
delirium, electroencephalographic alterations and cortical spreading depression (csd) in critical illness

Conditions: Delirium

Summary: delirium in the intensive care unit is an acutely developed brain dysfunction affecting up to 80 % of patients. it is associated with significantly increased morbidity and mortality during admission and post-discharge. the mechanism behind the condition is poorly understood but assumably multifactorial, and the purpose of this study is to investigate the pathophysiology further.

the pathophysiology behind delirium in critical illness is not clarified but assumed to involve inflammation, changes in cerebral perfusion and neurotransmission, sleep deprivation and the use of i.e. sedatives. cortical spreading depression is a phenomenon occuring in critically ill patients with acute cerebral trauma and likely associated with significant secondary neuron damage. the hypothesis is that 1. delirium in critically ill patients without acute cerebral damage is a clinical manifestation of cortical spreading depression and can be recorded in a noninvasive direct current-electroencephalography 2. electroencephalographic alterations or potentially specific signatures occur in delirium and thus, delirium can be predicted by recording continuous alternate current electroencephalography on admission in an icu

Eligibility criteria:
inclusion criteria: * expected admission in the icu \>24 hours exclusion criteria: * cerebral trauma \<6 months * existing delirium * severe dementia

Keywords: delirium, electroencephalography, csd
calerie (pbrc, baton rouge) - comprehensive assessment of long-term effects of reducing intake of energy

Conditions: Aging; Cardiovascular Disease; Diabetes Mellitus

Summary: this study is one of three calerie trials that test the hypothesis that a reduced calorie, nutritionally sound diet improves biomarkers of aging and prevents some age-related chronic diseases such as cancer, diabetes, and cardiovascular disease. the three sites that are participating in the calerie trial represent a diversity of subject populations and interventional strategies.

this study tests whether chronic caloric restriction improves risk factors of longevity in humans as it is known to do in animals, by measuring a variety of factors dealing with metabolism and oxidative stress, through physical evaluations and laboratory tests. participants will receive dietary counseling and free medical evaluations. in addition, each volunteer will be asked to do one of the following: 1. follow a reduced calorie diet 2. follow a reduced calorie diet using a liquid diet 3. increase physical activity while on a reduced calorie diet 4. follow a standard diet. three separate five-day inpatient stays are required.

Eligibility criteria:
inclusion criteria: * resident of greater baton rouge area for 1 year or longer * men between ages 25-50 * women between ages 25-45 * body mass index (bmi) between 25-30 (never having had bmi greater than 32) * healthy, non-smokers with no history of cardiovascular disease, high blood pressure, diabetes, eating disorder, or major psychiatric disorder exclusion criteria: * pregnant or breastfeeding * personal history of cardiovascular disease or elevated high blood pressure (higher than 160/90 mmhg) * abnormal electrocardiogram (ekg) * personal history of diabetes * personal history of major psychiatric disorders * personal history of eating disorder * smoking * exercising regularly (more than twice a week) * individuals with alcoholism or other substance abuse * post obese (never have had a bmi greater than 32) * regular use of medications, except oral contraceptives * individuals who were ever injured by a metallic foreign body which was not removed * individuals who wear braces on their teeth, have non-removable false teeth, or non-removable bridgework * individuals in occupations requiring full alertness and motor skills (airline pilots, etc.) where even a small chance of postural dizziness would be unacceptable.

Keywords: longevity dietary restriction physical activity weight loss diabetes
accelerating gastrointestinal recovery

Conditions: Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer

Summary: this study is designed to determine whether an oral perioperative medication (alvimopan--a selective mu antagonist) improves bowel recovery over placebo after surgery for ovarian cancer.


Eligibility criteria:
inclusion criteria: * females at least 18 years of age * have an american society of anesthesiologists (asa) score of i to iii * are consented for primary, interval, or secondary cytoreduction for ovarian, tubal, or peritoneal cancer * are scheduled to have their nasogastric tube removed before the first postoperative dose of study medication * are able to understand the study procedures, have agreed to participate in the study program, and have voluntarily provided informed consent exclusion criteria: * females younger than 18 years of age * known non-gynecologic malignancy presenting with similar signs/symptoms as ovarian, tubal, or peritoneal cancer. * have taken more than 7 consecutive days of therapeutic doses of opioids immediately prior to surgery * use illicit drugs or abuse alcohol * have had a prior total colectomy, gastrectomy, gastric bypass, or have a functional colostomy or ileostomy * have an ongoing history of short bowel syndrome, chronic constipation (≤3 spontaneous bowel movements per week) or chronic diarrhea * have received radiation therapy to the abdomen or pelvis within 3 months of scheduled surgery * have chemotherapy or radiation induced bowel dysfunction * are pregnant (identified by a positive urine or serum pregnancy test) or lactating, or are not postmenopausal (no menses for at least 1 year) and are of childbearing potential and not using an accepted method of birth control (ie, surgical sterilization, intrauterine contraceptive device, oral contraceptive, diaphragm, or condom in combination with contraceptive cream, jelly, or foam, or abstinence) * have participated in another investigational drug or medical device study within 30 days of surgery or will be enrolled in another investigational drug or medical device study or any study in which active patient participation is required outside normal hospital data collection during the course of this study * have clinically significant laboratory abnormalities at screening that would result in the cancellation of surgery * have a diagnosis of severe hepatic insufficiency or end stage renal disease. * have a history of previous surgeries, illness, or behavior that in the opinion of the investigator might confound the study results or pose additional risk in administering the study procedures * are unable to understand the study procedures and are not able to voluntarily provided informed consent

Keywords: ovary ovarian fallopian peritoneal cancer gynecological female
three small doses of hcg versus booster dose of hcg on ovum pickup day

Conditions: Infertility

Summary: to salvage the luteal phase and improve pregnancy rate in antagonist ivf/icsi cycles triggered with gnrh agonist. two strategies are compared supplementing the luteal phase with three small doses (500 iu) of hcg and giving a booster dose of hcg (1500 iu) on the day of ovum pickup.


Eligibility criteria:
inclusion criteria: * high responder females undergoing antagonist protocol ivf/icsi cycle * more than 14 mii oocytes * estradiol more than 3500 pg/ml on day of trigger exclusion criteria: * any other protocol * normal or poor responders
microbiota transplantation in solid organ transplantation

Conditions: Solid Organ Transplant Complications

Summary: solid organ transplantation (sot), an alternative therapy for end-stage diseases, offers increased longevity and better quantity of life. posttransplant complications such as gastrointestinal symptoms, infection, and graft rejection increase risk with graft failure and death. however, the treatment of abovementioned complications remains unsatisfactory. gut dysbiosis has been reported in patients with sot, especially in patients with posttransplant complications. recipients are more susceptible to gut dysbiosis as long-term use of immunosuppressants, antibiotics and corticosteroids. restoring gut microbiome may be a promising therapy for posttransplant complications. washed microbiota transplantation (wmt) is a newly improved methodology of fecal microbiota transplantation based on automatic facilities, washing process and a new delivery routine. in this study, investigators aimed to evaluate the efficacy and safety of wmt for postoperative complications in sot.


Eligibility criteria:
inclusion criteria: 1. solid organ transplantation recipients; 2. suffering from gastrointestinal symptoms (e.g. diarrhea, constipation, abdominal pian), infection (e.g. clostridium difficile) post-transplantation and so on; 3. is willing to undergo wmt and provide written informed consent. exclusion criteria: 1. patients with history of gastrointestinal diseases or homologous pathogen infection pre-transplant; 2. pregnant or lactating females; 3. expected survival\<1 months; 4. unable to understand the purpose of the study, communicate effectively with investigators and comply with all study procedures; 5. follow up less than 1-month post-wmt; 6. other conditions judged by investigators not suitable for study participation.

Keywords: solid organ transplant complications washed microbiota transplantation fecal microbiota transplantation diarrhea
atherectomy and drug coated balloon for the treatment of arterio-venous graft stenosis

Conditions: Dysfunctional Arterial-venous Grafts

Summary: this single-centre, single-arm, prospective study will enroll 30 subjects presenting with clinical and hemodynamic abnormalities in arteriovenous graft (avg) in the arm. subjects will be treated with the jetstream™ atherectomy device and ranger™ drug coated balloons (dcb). subjects will be followed up clinically via office visit or phone visit at 6 and 12 months post procedure. this study is to demonstrate safety and assess the clinical use and outcomes of the jetstream ™atherectomy device and ranger™ dcb for the treatment of dysfunctional av graft.


Eligibility criteria:
inclusion criteria: * male or non-pregnant, non-breastfeeding female ≥18 years of age; * subject is willing to provide informed consent, and is willing to comply with the protocol-required follow up visits; * target lesion must be a mature arteriovenous graft presenting with any clinical, physiological or hemodynamic abnormalities warranting angiographic imaging as defined in the k/doqi guidelines; * subject has a target lesion at the venous anastomosis of the avg; * successful crossing of the stenosis; * each lesion length is ≤20mm, which may include tandem lesions that are ≤20mm apart exclusion criteria: * subject is currently participating in an investigational drug or device study which has not yet reached its primary endpoint or was previously enrolled into this study; * subject has a non-controllable allergy to contrast; * subject has more than 3 lesions in the access circuit requiring intervention; * target lesion diameter \>10mm; * a thrombosed access or an access with a thrombosis treated ≤30 days prior to the index procedure; * prior surgical interventions of the access site ≤30 days before the index procedure; * target lesion is located within a bare metal or covered stent.