Kornimate/medical-research-clean huggingface dataset:
weight management in overweight endometrial cancer patients undergoing fertility-sparing treatment

Conditions: Endometrium Cancer

Summary: in this study, overweight and obese patients with endometrial cancer treated with fertility- sparing therapy were randomly divided into two groups. the test group was given weight management, while the control group was given routine care. relevant information such as body morphology and composition, glycolipid metabolism, molecular typing and tumor outcomes of the subjects were collected. by evaluating the tumor outcome and changes in glycolipid metabolism indicators, to confirm the effectiveness and safety of weight management for overweight and obese patients with endometrial cancer and treatd with fertility preservation.

obesity is recognized as a major risk factor for the development of endometrial cancer. notably, several retrospective studies have shown that obesity reduces complete remission and pregnancy rates and increases recurrence rates in patients with endometrial cancer and atypical hyperplasia who undergo fertility-sparing treatment. guidelines or consensus statements for fertility-sparing treatment in endometrial cancer recommend weight management. however, prospective intervention studies on the effectiveness of systematic weight management models in patients receiving reproductive function-preserving treatment for endometrial cancer and atypical hyperplasia are lacking. this study therefore aimed to investigate the impact of the weight management on body morphology and composition, glycolipid metabolism, and tumor outcomes in overweight and obese patients with endometrial cancer and atypical hyperplasia who underwent reproductive function-preserving treatments.in this study, overweight and obese patients with endometrial cancer treated with fertility- sparing therapy were randomly divided into two groups. the test group was given weight management, while the control group was given routine care. relevant information such as body morphology and composition, glycolipid metabolism, molecular typing and tumor outcomes of the subjects were collected. by evaluating the tumor outcome and changes in glycolipid metabolism indicators, to confirm the effectiveness and safety of weight management for overweight and obese patients with endometrial cancer and treatd with fertility preservation.

Eligibility criteria:
inclusion criteria: * age ≥18 years old * diagnosed as endometrial cancer or atypical hyperplasia * immunohistochemical staining and sequencing of pathological tissue * fertility-preserving therapy * bmi≥25 kg/m2 * informed consent. exclusion criteria: * those with communication barriers * pregnant women * medical and surgical serious complications: urinary calculi, history of renal failure or severe renal insufficiency, familial dyslipidemia, severe liver disease, chronic metabolic acidosis, history of pancreatitis, severe diabetes mellitus, active gallbladder disease, fat dyspepsia, severe cardiovascular and cerebrovascular diseases.
investigation of the development of infants with a history of colic

Conditions: Colic, Infantile; Motor Development; Sleep; Sensory Integration Dysfunction

Summary: the aim of this study was to evaluate the motor development, sleep characteristics and sensory processing skills of infants with a history of colic and to compare them with their peers without a history of colic.

infantile colic (ic) is a condition characterized by incessant crying and restlessness in healthy, normally growing infants. prolonged and intense crying in an otherwise healthy infant is a significant challenge for families. infantile colic was first described by wessel nearly 50 years ago. according to wessel, episodes of crying and restlessness that last three hours a day, at least three days a week, for a minimum of three weeks are classified as infantile colic. the long-term effects of ic include an increased risk of behavioral problems in children. a meta-analysis found that children with a history of excessive crying are more likely to develop general behavioral problems, internalizing problems (such as anxiety, depression, or withdrawal), and externalizing problems (such as aggression or disruptive behavior). additionally, these difficulties are exacerbated by adverse family environments, including parental stress or poor maternal mental health. as these infants approach preschool age, they may struggle with sustaining attention, engaging in reciprocal play interactions, and tolerating change and separation. the first two years of life are a critical period for supporting infant development, as brain growth and neural plasticity progress rapidly. when children reach 10-15 months of age and begin exploring their environment through walking and trial-and-error experiences, assessing sensory processing skills becomes particularly important. at this stage, children actively expand their motor repertoire, especially while developing skills such as crawling and walking. however, a review of existing studies reveals a lack of evaluations conducted during the toddler, preschool, and school-age periods. furthermore, most studies focus primarily on behavioral problems and attention deficit hyperactivity disorder (adhd). for this reason, 10-15-month-old infants were included in this study to assess early-stage development.

Eligibility criteria:
inclusion criteria: * term infatns born at term * infants diagnosed with colic * post-term infants between 10-15 months exclusion criteria: * premature infants * infants with congenital malformations * infants diagnosed with metabolic, neurological and genetic diseases * children whose parents do not volunteer for the study

Keywords: infantile colic developmental outcomes motor development sensory processing sleep
evaluation of posterior component separation modified tar technique "transversus abdominids release" in the treatment of parastomal hernia

Conditions: TAR Technique

Summary: aim of the work in this study, we will evaluate posterior evaluation of posterior component separation modified tar technique "transversus abdominids release" in the treatment of parastomal hernia. the primary outcome will be recurrence while the secondary outcome will be infection, postoperative complications (bleeding and dehiscence), pain score, operative time, hospitalization, need for drain, time for drain removal and pulmonary function test before and after surgery


Eligibility criteria:
inclusion criteria: * adult patient fit for general anesthesia with parastomal herniation. exclusion criteria: * patients who are unfit for general anaesthesia. * poor pulmonary function tests. * pregnant females. * patient younger than 18 years. * immunodeficiency. * patient with psychiatric disease disabling surgical intervention.
lateral prostate capsule sparing versus nerve sparing robot-assisted radical cystectomy-orthotopic ileal neobladder for bladder cancer in the male

Conditions: Bladder Cancer

Summary: to compare the perioperative, functional, and oncologic outcomes between nerve sparing and lateral prostate capsule sparing robot-assisted radical cystectomy with orthotopic ileal neobladder in male patients with bladder cancer.

this study will enroll male patients with bladder cancer who will undergo robot-assisted radical cystectomy with orthotopic ileal neobladder. the patients will be distributed into two comparable groups according to surgical procedures: nerve sparing group and lateral prostate capsule sparing group. patient demographics and pathologic, perioperative, functional, and oncologic outcomes will be compared between the two groups.

Eligibility criteria:
inclusion criteria: 1. male patients aged 18 or older. 2. patients those who are diagnosed with urothelial carcinoma. 3. patients those who are without tumour in the bladder neck or urethra, and prostate cancer was ruled out by mri and serum t-psa\<2.5ng/ml. 4. patients those who are capable of receiving radical cystectomy with orthotopic ileal neobladder. 5. patients those who are able to cooperate and complete the follow-up. 6. patients those who volunteer to participate in this study and sign the informed consens. exclusion criteria: 1. patients thsoe who are diagnosed distant metastasis before surgery. 2. patients those who are diagnosed with other malignancies. 3. patients those who had received pelvic radiotherapy or major pelvic operation.
environmental intervention on delirious patients

Conditions: Delirium

Summary: the implementation of environmental intervention program reduced the duration of delirium and length of stay at the icu in critically-ill surgical patients.

purpose: delirium occurs among patients in intensive care unit at high rates and increases the risk for morbidity and mortality. the purpose of this study is to investigate the effects of environmental interventions for the prevention of delirium. methods: a total of 192 patients who had been admitted to the surgical intensive care unit (sicu) in asan medical center during the pre-intervention period (jun 2013 to oct 2013) and the post-intervention period (jun 2014 to oct 2014) was enrolled and prospective cohort study was done. the environmental intervention included cognitive assessment, providing orientation and comfortable environment, and a proper sleeping environment. the primary outcomes were the incidence rate of delirium, time of delirium onset, and the duration of delirium.

Eligibility criteria:
inclusion criteria: * with an age of 18 years or older * who understood the purpose of this study and agreed to participate * stayed in the sicu for a period of 48 hours or longer exclusion criteria: * who remained unresponsive \[defined as the richmond agitation-sedation scale (rass) less than -4\] * who could not measure confusion assessment method (cam-icu) due to severe visual or hearing disturbance * who had a history of severe psychiatric or neurologic deficit * who required an isolation room due to transplantation or immunologic compromise * who were discharged from icu within 48 hours * who were re-admitted to the icu * who were less than 18 years old * who were admitted to the surgical icu through another icu

Keywords: intensive care unit critically ill patients environmental intervention
gastric emptying of water in obese term pregnant women

Conditions: Pregnancy Related

Summary: it has been believed that the risk of pulmonary aspiration in term pregnant women is increased, and should be considered that all term pregnant women to have "full stomach". recently, gastric ultrasound has been adopted as a useful tool for quantitative and qualitative assessment of stomach before anesthesia, and predict the risk of pulmonary aspiration. although, both the obesity and pregnancy are known to be the risk of pulmonary aspiration, it is suggested in the american society of anesthesiology fasting guidelines, that the same fasting time should be applied in the obese and non-obese parturients. however, this was based on one study done in a small (10) numbers of volunteers. therefore, the investigators aimed to compare the gastric antral cross-sectional area in both obese and non-obese term pregnant women, scheduled for elective cesarean section.

this study is a prospective, observational study. 42 term (≥37 weeks) pregnant, non-laboring adult women scheduled for cesarean delivery will be included in the study. they will be allowed to drink water freely, until 2 hours before the anesthesia. gastric ultrasound will be performed in 21 non-obese women, and 21 obese women. the obesity is defined by the body mass index at term.

Eligibility criteria:
inclusion criteria: * non laboring, term (≥37 weeks) pregnant women * scheduled for elective cesarean section * aged ≥ 18 years old * american society of anesthesiology physical class 1-3 exclusion criteria: * multigestational pregnancy * diagnosed for delayed gastric emptying (gerd, gastrointestinal disease) * diabetes
the effect of irrisept for irrigation of skin and soft tissue infections (irrisept usf study)

Conditions: Skin and Soft Tissue Infections; Abscess

Summary: the purpose of this study was to determine whether irrisept can effectively prevent the progression of skin and soft tissue infections (sstis) as compared to treatment by the current standard of care.

after being informed about the trial and potential risks, subjects completed an informed consent form prior to participation. after eligibility criteria was verified, an initial wound assessment examination was performed. subjects were then randomized to the irrisept or standard of care treatment group. forty-eight hours later, wound progression and signs of infection were assessed.

Eligibility criteria:
inclusion criteria: 1. age 18 to 80 2. skin and soft tissue infections (sstis), in the form of an abscess, which will require incision and drainage. 3. patient able to provide an informed consent. 4. patient volunteers to participate. exclusion criteria: 1. wound was caused by human or animal bite. 2. wound is a blunt crush injury or has tendon, bone, or joint involvement. 3. diabetic foot infection. 4. anticipated incision size less than 5mm. 5. abscess extends to the muscle layer. 6. admission to hospital for any reason, including iv antibiotics. 7. clinical signs of systemic infection on initial patient encounter. 8. prior history of allergy or hypersensitivity to chg. 9. neutropenic (known anc\<500/mm3), hiv (known cd4\<50), or other severely immunocompromised state (e.g., receiving chemotherapy). 10. patient is diagnosed with systemic lupus erythematosus or other immunological disease. 11. currently in police custody. 12. patient withdraws from participation. 13. patient unable or unwilling to give informed consent.
infection after implant-based breast reconstruction

Conditions: Breast Implant Infection

Summary: infections following postmastectomy breast reconstruction can compromise surgical outcomes and lead to significant morbidity. the aim of this study was to determine factors associated with infection following two-stage implant-based reconstruction.


Eligibility criteria:
inclusion criteria: * patients who received implant-based breast reconstruction following mastectomy between 2015 and 2020 in seoul national university hospital exclusion criteria: * patients who received flap surgery simultaneously with implant insertion
a long-term safety and efficacy study of danicopan as an add-on therapy to complement component 5 inhibitor (c5i) in participants with pnh

Conditions: Paroxysmal Nocturnal Hemoglobinuria

Summary: this is a single-arm long-term extension study that will enroll participants with pnh who have completed participation in alexion-sponsored clinical studies with danicopan as an add on therapy to a c5i.

the total duration of the study will be up to 3 years. eligible participants must complete all study assessments on the parent protocol before starting this study. all participants entering this study will receive danicopan as an add-on to a background c5i therapy. the only allowed c5i therapies are eculizumab and ravulizumab.

Eligibility criteria:
key inclusion criteria: * all participants who completed their participation in an alexion sponsored clinical study with danicopan as an add on to a c5i treatment. * patient is capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form and in this protocol. * documentation of vaccination for neisseria meningitidis: all participants must be revaccinated as per national vaccination guidelines or local practice for vaccination use with complement inhibitors. key exclusion criteria: * any medical condition (for example, cardiac, pulmonary, renal, oncologic, or psychiatric) that, in the opinion of the investigator, might interfere with participation in the study, pose any added risk to the participant, or confound the assessment of the participant. * patient has been permanently discontinued from danicopan in the parent study for any reason other than enrollment into this lte study. * female participants who are pregnant, breastfeeding, or intending to conceive during the course of the study.

Keywords: paroxysmal nocturnal hemoglobinuria (pnh) extravascular hemolysis (evh) factor d inhibitor complement danicopan alxn2040 c5 inhibitor
two anti-cd20 regimens for fibrillary glomerulonephritis

Conditions: Fibrillary Glomerulonephritis

Summary: this study aims to evaluate the clinical and histological effects of two rituximab-based regimens in fibrillary glomerulonephritis.


Eligibility criteria:
inclusion criteria: -fibrillary glomerulonephritis (biospy proven defined by optical microscopy, immunofluorescence and electron microscopy studies with demonstration of the dnajb9 protein) exclusion criteria: * previous treatment with anti-cd20; pregnant; unable to consent. other concomitant gn.

Keywords: fibrillary glomerulonephritis anti-cd20
a retrospective analysis: the influence of caltrate supplement on the effect of mesalazine in ulcerative colitis

Conditions: Ulcerative Colitis; Vitamin D Deficiency; Vitamin D Supplement

Summary: aims:retrospectively observe the effects of caltrate supplementation on the clinical effect of mesalazine in patients with ulcerative colitis. design: from january 2015 to december 2020, through retrieving the clinical database of the second affiliated hospital of wenzhou medical university, patients with active uc who accepted mesalazine treatment were enrolled. according to whether caltrate was supplemented at the same time, the patients were divided into supplementary group and non-supplementary group. the modified mayo score and several laboratory indicators were compared between the two groups.

1. the research has been approved by the medical ethics committee of the second affiliated hospital of wenzhou medical university. 2. according to the "consensus on diagnosis and treatment of inflammatory bowel disease" formulated by the beijing conference in 2018 as a standard, patients with clear diagnosis of uc are collected. exclusion criteria included: history of vitamin d treatment within the previous 3 months; treated with glucocorticoids, immunosuppressants, biologic agents, or colectomy during the follow-up; severe liver and kidney dysfunction; other autoimmune diseases. 3. assess disease activity of uc participants based on the "mayo score". 4. general information about participants with uc is collected. 5. serum c-reactive protein, erythrocyte sedimentation rate, white blood cells, albumin, creatinine, calcium and phosphorus levels are measured. 6. the level of serum 25 (oh) d of participants is detected. 7. participants are divided into two groups, one group was given oral caltrate 0.6g/d +mesalazine, and the other group only took mesalazine . 8. the above serum indicators are re-measured in the 12th month, and the condition of uc participants is also evaluated. 9. follow-up for 12 months. by comparing the above indicators, observe that in the han population: 1. can caltrate supplementation increase serum 25 (oh) d levels in patients with uc? 2. can caltrate supplementation improve the condition of patients with uc? 3. whether caltrate works synergistically with mesalazine? 4. whether the effect of caltrate on uc patients is affected by factors such as disease site, disease activity, treatment, etc .. 10. through statistical analysis, comprehensive analysis of the effectiveness and safety of caltrate supplementation in han patients with uc, providing a theoretical basis for further "precise treatment" intervention in inflammatory bowel disease.

Eligibility criteria:
inclusion criteria: * clearly diagnosed patients with uc * took mesalazine for at least 12 months exclusion criteria: * had recent supplementation of vitd3 * had prior or concomitant use of other biologic agent, glucocorticoid and/or immunomodulators at the time of enrollment or follow up * co-morbid with other autoimmune diseases * severe liver and kidney dysfunction
follow-up of patients operated upon for type ii-iv hiatal hernia

Conditions: Gastroesophageal Reflux Disease With Hiatal Hernia; Paraesophageal Hernia

Summary: surgical therapy for gastroesophageal reflux disease (gerd) and hiatal hernia (hh) can achieve outcomes that afford the patient lifelong satisfaction. the published results obtained with this surgery may not be considered to be definitive in relation to the length of follow-up or patients' life expectancy. the real recurrence rates and the results of surgery for gerd are difficult to assess due to the lack of serial time points during the follow-up. further bias may have been introduced into the analysis by a lack of appropriate controls. the results of surgical therapy for type ii-iv hh are even more controversial because of the high rate of anatomical relapse and the different methods of follow-up adopted in reported case series. aim of this study is to clarify the value of surgical therapy for type ii-iv hh. the investigators report on patients who were followed up after surgery at various time points over the course of 30 years.

we reviewed the charts of patients who underwent primary surgery for type ii-iv hiatal hernia during the period from january 1980 - december 2010. pre-operatively, the patients routinely underwent symptom assessment, a barium swallow, upper gi endoscopy and esophageal manometry. the principles of surgery for gerd and hiatal hernias involve full isolation of the diaphragmatic pillars and e-g junction, full isolation and resection of the sac and fat pad into the mediastinum (except for the fat close to the lesser curvature, to preserve the integrity of the vagus nerves), evaluation of the degree of esophageal shortening, and a collis gastroplasty in cases of short esophagi. post-operatively, the patients participated in a free-of-charge outpatient follow-up program at 6 months, 12 months and every year for 5 years. the length of the follow-up was calculated from the day of the surgery to the day that the patient underwent the last complete follow-up. the type and severity of symptoms and the grade of reflux esophagitis were scored using a questionnaire with semi-quantitative scales (from 0 = absence of symptoms and esophagitis to 3 = severe symptoms and esophagitis). an evaluation scale for the surgical results, with scores ranging from "excellent" to "poor", was also used.

Eligibility criteria:
inclusion criteria: * patients aged \> 18 years, undergoing surgery for the treatment of type ii-iv hiatal hernia ± gerd. exclusion criteria: * association of gerd with epiphrenic esophageal diverticulum * collagen diseases * undetermined esophageal motility disorders, redo antireflux surgery * previous surgery on the thoracic and abdominal esophagus and stomach, on the diaphragm.

Keywords: gastroesophageal reflux diseases hiatal hernia paraesophageal hernia