Kornimate/medical-research-clean huggingface dataset:
efficacy study of a selective chest wall restriction belt in postoperative of lung resection

Conditions: Lung Cancer

Summary: the objective of this study is to evaluate the efficacy of a new medical device in post-surgery of lung resection. the principle of this new device is based on selective chest wall restriction. this new modality of chest wall restriction is evaluated on patients in post-surgery for lung cancer. the hypothesis is that the use of this medical device would reduce the postoperative pain and increase the efficacy of cough and expectoration. the evolution of the operated patient would be better.

the present study is the first evaluation of the efficacy of a selective chest wall restriction belt. the efficacy will be estimate on forced expiratory volume in one second (fev1) at d3 by comparing 2 groups: a control group of patients with conventional follow-up and an experimental group of patients with conventional follow-up and a daily wear of the selective chest wall restriction belt after surgery.

Eligibility criteria:
inclusion criteria : * patients with segmentectomy or lobectomy for lung cancer or lung cancer suspicious, * surgical approach : video-assisted thoracic surgery (vats) or thoracotomy, * patients affiliated to social security or similarly regime, * patients who gave their consent to participate in the study. exclusion criteria : * patients with outcomes of the pulmonary function test at the preoperative assessment : forced expiratory volume in one second (fev1) or diffusing capacity of the lung for carbon monoxide (dlco) \> 45% predicted post-operative values and vo2max (maximal oxygen consumption) between 10 and 12 ml/kg/min, * patients with a waist size \> 120 cm * patients with medical treatment for chronic pain (neuropathic pain,...) * patients with tuberculosis or other pulmonary infectious pathology proven (aspergillosis, lung abscess, actinomycosis,...), * patients carrying a resistant germs or extended-spectrum beta-lactamase (esbl), * paraplegic patients * patients with a diagnosed, progressive and/or uncontrolled neurological disease * patients with a progressive psychosis or a serious psychotic history (hospitalization) * patients who are in exclusion period of another interventional study * protected person referred to in articles l1121-5 to l1121-8 of the code of public health

Keywords: chest wall restriction usability lung surgery medical device pain cough expectoration
effects of mirror therapy on pain and function on bilateral carpal tunnel syndrom

Conditions: Carpal Tunnel Syndrome

Summary: the purpose of this study was to evaluate pain and function after mirror therapy as well as level of catastrophism in bilateral carpal tunnel syndrome patients

the sample calculation was performed based on the previous pilot study, in which 10 subjects were included. through this study, a statistically significant effect on the variables analyzed was demonstrated. therefore, it was determined to duplicate the initial sample to confirm the effect previously studied, assuming losses of 20%. thus, the value of n for the clinical trial is 20 subjects.

Eligibility criteria:
inclusion criteria: * must be signed the informed consent. * bilateral carpal tunnel syndrome: clinic and electromiography positive. * aged between 18 and 65 years exclusion criteria: * patients undergoing surgical intervention of carpal tunnel syndrome in one of two hands * unilateral carpal tunnel syndrome * patients with chronic pain and / or previous injury (wrist tumor, lymphedema ...) in either hand * patients with systemic diseases (diabetes, thyroid ...) * patients with pharmacological treatment to take analgesia for any other chronic pathologies * subjects who have suffered from a neurological disease that affects the musculoskeletal system * mental illness that prevents the compression and / or realization of the study * patients with tattoos, scars and / or marks on any of the hands or distal forearm area * pregnant women and minors

Keywords: adult chronic pain entrapment neuropathy. carpal tunnel exercise therapy humans neuronal plasticity mirror neurons pain/cognitive aspects physiotherapy somatosensory cortex
evaluation of pulmonary function in burn injury

Conditions: Burns

Summary: this study evaluates the pulmonary function, respiratory muscle strength and peripheral muscle strength in patients with burn injury on the week that they will be discharge from the hospital. healthy subjects will be evaluated for pulmonary function, respiratory muscle strength and peripheral muscle strength.

burn injures have adverse effect on the respiratory system.in addition to burn injury prolonged hospitalization may increase the ratio of respiratory complications. but, there are no information in the literature about pulmonary function, respiratory muscle strength and peripheral muscle strength in patients with burn injury. especially, when the patients are discharged from the hospital, it is not known whether the patients are at the same level in terms of pulmonary functions respiratory muscle strength and peripheral muscle strength with healthy individuals. this study will assess pulmonary functions respiratory muscle strength and peripheral muscle strength in patients with burn injury compared to healthy subjects.

Eligibility criteria:
inclusion criteria: * having a burn injury * treatment by an inpatient * able and willing to complete the informed consent process. * control group consists of healthy adults with the similar demographic characteristics as experimental group exclusion criteria: * having a pulmonary system disease * having a cardiac system disease * to do regular sports for the last three months

Keywords: burn injury pulmonary function respiratory muscle peripheral muscle
dect ventilation imaging

Conditions: For Oncologic Patients; Potentially Operable Lung Tumor; With a Recent (Less Than 1 Month) VQ Scan; For Lung Transplant Recipients; Single of Bilateral Lung Transplant; From 5 Months Onwards; With Recent (Less Than 1 Month) Respiratory Functional Explorations

Summary: demonstrate the feasibility of dual energy computed tomography using krypton as a gaseous contrast media in order to study the in vivo ventilation. two different clinical situations will be tested : * prediction of postoperative pulmonary function for oncologic patients * detection of bronchiolitis obliterans in lung transplant recipients.


Eligibility criteria:
inclusion criteria: for oncologic patients : * potentially operable lung tumor * with a recent (less than 1 month) v/q scan for lung transplant recipients : * single of bilateral lung transplant * from 5 months onwards * with recent (less than 1 month) respiratory functional explorations exclusion criteria: * impossibility to follow simple orders or control one's respiration * known krypton hypersensitivity * history of malignant hyperthermia * increased intracranial pressure * minors * pregnant women
pulsed radiofrequency treatment of the gasserian ganglion for trigeminal neuralgia: a retrospective study

Conditions: Trigeminal Neuralgia (TN)

Summary: with the pulsed radiofrequency treatment (prf) of the gasserian ganglion for trigeminal neuralgia: a retrospective study (progress) the objective is to document the outcome of prf (pulsed radiofrequency treatment) for patients with tn (trigeminal neuralgia), unresponsive to conservative treatment.

primary objective: to determine the proportion of patients in which prf (pulsed radiofrequency) of the gasserian ganglion for trigeminal neuralgia (tn) provides acute pain relief of at least 50% on the gpe (global perceived effect) score (six weeks after treatment) secondary objectives: - to determine the duration during which prf of the gasserian ganglion for trigeminal neuralgia provides a reduction of at least 50% on the gpe (grade point equivalent) score.

Eligibility criteria:
inclusion criteria: * patients with trigeminal neuralgia who underwent their first prf of the gasserian ganglion between 01/09/2013 and 31/08/2021 exclusion criteria: * none
impact of right ventricular pacing determined by electrocardiography

Conditions: Atrioventricular Block

Summary: typically pacemaker electrode has been attached to the right ventricular apex. this method lead to non-physiological ventricular contraction. it has been reported to cause by ventricular dysfunction. in conclusion, this study demonstrate that impact of right ventricular pacing determined by electrocardiography was planned.

patients who has atrioventricular block scheduled for artificial pacemaker randomized select 1:1 apex beats and ventricular septal beat.

Eligibility criteria:
inclusion criteria: * atrioventricular block, pacemaker scheduled exclusion criteria: * history of myocardial infarction * valvular heart disease (grade ≥ 2 ) * history of left ventricular dysfunction ( ejection fraction \ 60 mm in the pre-procedure echocardiogram)

Keywords: atrioventricular block, cardiomyopathy
a study of bevacizumab (avastin) in neoadjuvant therapy in participants with international federation of gynecology and obstetrics (figo) stage iiic/iv ovarian, tubal, or peritoneal cancer, initially unresectable

Conditions: Ovarian Cancer

Summary: this randomized, open-label study will evaluate the efficacy and safety of neoadjuvant bevacizumab in participants with initially unresectable, figo stage iiic/iv ovarian, tubal, or peritoneal cancer. participants will be randomized to receive 8 cycles of carboplatin plus paclitaxel with or without bevacizumab before surgery (interval debulking surgery \[ids\]). surgery will be scheduled 28 days after the last course of neoadjuvant treatment in participants with resectable cancer. participants with unresectable cancer will go through the follow-up period. all participants will receive bevacizumab for cycles 6 to 26.


Eligibility criteria:
inclusion criteria: * histologically confirmed and documented high-risk figo stage iiic/iv epithelial ovarian carcinoma, fallopian tube carcinoma, or primary peritoneal carcinoma * not eligible for primary complete debulking surgery during a laparoscopic procedure as judged by a surgeon experienced in management of ovarian cancer * eastern cooperative oncology group (ecog) performance status 0, 1, or 2 * life expectancy greater than or equal to (\>/=) 3 months * eligible for carboplatin and paclitaxel chemotherapy in accordance with local standards * beneficiaries of healthcare coverage under the social security system exclusion criteria: * non-epithelial ovarian cancer, ovarian tumor with low malignant potential, mucinous and clear cell ovarian cancer, or carcinosarcoma * evidence of abdominal free air not explained by paracentesis or recent surgical procedure * previous systemic therapy for ovarian cancer * previous exposure to mouse ca-125 antibody * current or recent (within 28 days prior to day 1 of cycle 1) treatment with another investigational drug or previous participation in this study * current or recent (within 10 days prior to first study drug dose) chronic daily treatment with aspirin greater than (\>) 325 milligrams (mg) per day * planned intraperitoneal cytotoxic chemotherapy * inadequate bone marrow, liver, or renal function * history of myocardial infarction, unstable angina, stroke, or transient ischemic attack within 6 months prior to day 1 of cycle 1 * uncontrolled hypertension * clinically significant (active) cardiovascular disease such as new york heart association (nyha) class ii or greater congestive heart failure, or aortic aneurism * pre-existing peripheral neuropathy that is common toxicity criteria (ctc) grade \>/=2 * known hypersensitivity to bevacizumab or its excipients, chinese hamster ovary cell products or other recombinant humanized antibodies, or to any planned chemotherapy * pregnant or lactating females * history of other clinically active malignancy within 5 years of enrollment, except for tumors with a negligible risk for metastasis or death, such as adequately controlled basal-cell or squamous-cell carcinoma of the skin or carcinoma in situ of the cervix or breast
different fluorescein sodium dosage for the detection of gastric intestinal metaplasia

Conditions: Gastric Intestinal Metaplasia

Summary: the purpose of this study is to assess whether lower fluorescein sodium dosage can perceive the same detection rate per patient and per lesion for the detection of gastric intestinal metaplasia.

gastric intestinal metaplasia is regarded as an important premalignant lesion for intestinal type gastric cancer. currently, the histological assessment of gastric intestinal metaplasia still relies on the biopsies took from five sites that the updated sydney system recommended. this study aims to compare the diagnostic yield of gastric intestinal metaplasia from two different fluorescein sodium dosage and assess whether lower fluorescein sodium dosage can perceive the same detection rate per patient and per lesion for the detection of gastric intestinal metaplasia.

Eligibility criteria:
inclusion criteria: * patients with dyspeptic symptoms and aged 40 years or older * or patients with helicobacter pylori infection, or histologically verified gastric intestinal metaplasia or atrophic gastritis * or patients with family history of gastric cancer exclusion criteria: * presence of gastrectomy, acute gastrointestinal bleeding, or known gastric neoplasia * presence of conditions unsuitable for endoscopy procedure including coagulopathy, impaired cardiopulmonary function , pregnancy or breastfeeding * inability to provide informed consent
study evaluating sumanirole for the treatment of the signs and symptoms of early parkinson's disease.

Conditions: Parkinson Disease

Summary: the primary purpose of this study is to determine whether sumanirole is effective and safe in the treatment of the signs and symptoms of early parkinson's disease.


Eligibility criteria:
inclusion criteria: parkinson's disease of less than 7 years duration modified hoehn and yahr scale stages 1 through 3. age greater than or equal to 30 years old. men or women (women of childbearing potential must have a negative pregnancy test at screen) and both must use adequate contraceptive methods. patients who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures. exclusion criteria: atypical parkinson's disease syndromes due to drugs, metabolic disorders, encephalitis, or degenerative diseases. levodopa received for 1-year accumulated interval in the last two years. dopamine agonist medications or catechol-o-methyl transferase inhibitors in the 30 days prior to baseline. unstable dose regimes of hypnotics, anxiolytics or antidepressants dementia history of stereotaxic brain surgery, psychosis or active epilepsy within past year. participation in clinical trial within the previous 30 days. malignant melanoma or history of melanoma significant medical or pshychiatric condition.
severe pregnancy complications are associated with elevated factor viii plasma activity

Conditions: Pregnancy Complications; Preeclampsia; Placental Abruption; Intrauterine Fetal Growth Restriction; Intrauterine Fetal Death

Summary: congenital and acquired thrombophilia were identified as risk factors for thrombosis in systemic vessels.thrombophilias have also been recently found to be associated with preeclampsia, intrauterine fetal growth restriction (iugr), placental abruption, intrauterine fetal death (iufd) and repeated pregnancy loss.these severe pregnancy complications are thought to result from thrombotic events occurring in the uteroplacental circulation. accumulating data have established an association between elevated plasma activity of factor viii and thrombosis although the mechanism is still not defined and elevated factor viii activity is now regarded as being equivalent to thrombophilia. we intend to investigatthe association between factor viii levels and severe pregnancy complications which are considered to result from placental vascular pathology, i.e., preeclampsia, iugr, placental abruption and iufd. we hypothezise that the prevalence of elevated factor 8 will be higher among women with pregnancy complications compared to controls.


Eligibility criteria:
inclusion criteria: * women who had either normal pregnancy or complicated pregnancy. exclusion criteria: * other causes of pregnancy complication such as infections, anomalies and fetal malformations

Keywords: pregnancy complications: preeclampsia , severe iugr , iufd or placental abruption (n = 5).
synergistic anti-tumor effect of changtai keli for colon cancer patients

Conditions: Colon Cancer

Summary: the aim of this study is to evaluate the synergistic anti-tumor effect of changtai keli based on chemotherapy for colon cancer patients by a randomized, parallel-group, double-blind, multicenter clinical study.

although many therapies exist and are being developed to relieve symptoms for colon cancer, there are few randomized controlled clinical trials to evaluate comprehensive traditional chinese medicine (tcm) interventions in colon cancer. the aim of this study is to evaluate the synergistic anti-tumor effect of changtai keli based on chemotherapy for colon cancer patients. this is a multi-center, randomized, double-blind, placebo-controlled study to evaluate the synergistic anti-tumor effect of tcm on colon cancer patients. following a run-in period, approximately 360 subjects will be randomly assigned to conventional chemotherapy treatment group, changtai keli and conventional chemotherapy treatment group for 26 weeks. after the 26 weeks treatment period, subjects in two treatments arms will follow-up 36 months.

Eligibility criteria:
inclusion criteria: 1. collaboration from hospital oncology patients in hospital. confirmed by pathology or cytology for colon cancer, ⅱ a - ⅳ period of patients with colon cancer line (or late postoperative palliative chemotherapy). 2. age \> 18 years of age, and the 75 - year - old patient or less; 3. fitness score (ecog ps) 2 minutes or less, expected lifetime \> 6 months; 4. volunteered for the clinical research, and sign the informed consent. exclusion criteria: 1. patients with other primary malignant tumors within 1 year; 2. intentional, severe liver and kidney disease patients with serious obstacle and function; 3. pregnancy or lactation women, mental disorders to cooperate to complete the healer; 4. is in other subjects or attended other drugs test interval \< 3 months. 5. do not meet the inclusion criteria;

Keywords: changtai keli colon cancer
effectiveness of bowen technique vs muscle energy technique in neck pain.

Conditions: Neck Pain; Musculoskeletal Manipulation

Summary: mechanical neck pain, also known as non-specific neck pain, is a prevalent ailment that results from problems with spine and surrounding tissue function. trauma, degenerative changes, strained muscles, and bad posture are among the causes. the range of symptoms includes headaches, stiffness, and mild to severe pain. the goal of treatment is to strengthen the muscles and improve posture. the diagnosis is clinical. the bowen technique is a type of gentle bodywork therapy that promotes relaxation and overall rebalancing by using specific movements to activate the autonomic nerve system. it is sought for the improvement of general well-being, pain alleviation, and stress reduction. patients undergoing manual treatment will be asked to actively contract their muscles against regulated resistance using the muscle energy technique (met). it addresses problems including joint limitations and attempts to return muscles and joints to their normal functions.

the research, will last for ten months at the limit institute of health sciences in sahiwal, is a randomized controlled trial. with 10 participants in each group using a non-probability convenient sampling procedure, the sample size includes 10% attrition. computer users between the ages of 18 and 35 who work five to seven hours a day meet the inclusion criteria, but recent musculoskeletal injuries and a history of head or spine trauma are the exclusion criteria. one instrument used to collect data is the neck disability index (ndi). there are two established study groups: group b will receive muscle energy technique (met) and traditional physiotherapy, while group a will receive bowen therapy and conventional physiotherapy. blinding will be used, and the study will adhere to a recruitment, enrollment, and randomization procedure. spss version 23 will be used to analyze the data, and descriptive statistics, change over temporal analysis as well as tests of group comparison. the purpose of the study is to evaluate how the interventions affect people who use computers for extended periods in terms of their functional results and mechanical neck discomfort.

Eligibility criteria:
inclusion criteria: * computer users who work 5-7 hours daily. * age between 18 to 35 will be included. * both genders exclusion criteria: * any recent musculoskeletal injury of upper limb or spine. * history of any trauma of spine or head

Keywords: bowen therapy mechanical neck pain muscle energy technique
effect of moxifloxacin versus gatifloxacin on corneal epithelium following pterygium excision

Conditions: Primary Pterygium

Summary: the purpose of this study is to determine whether there is a difference in corneal epithelial healing rate and/or toxicity following pterygium excision, between eyes treated post-operatively by moxifloxacin(vigamox)versus gatifloxacin (zymar).


Eligibility criteria:
inclusion criteria: 1. diagnosis of primary pterygium with a clinical indication for surgery 2. informed consent exclusion criteria: 1. known allergic reaction to fluoroquinolones. 2. secondary\\recurrent pterygium or clinical suspected conjunctival tumor. 3. eye surgery in the last 6 months. 4. eye disorders: severe dry eye syndrome, ocular surface diseases, glaucoma, recurrent corneal erosions, chronic corneal diseases, after chemical burn. 5. low compliance. 6. pregnancy

Keywords: pterygium gatifloxacin moxifloxacin corneal epithelial defect