Kornimate/medical-research-clean huggingface dataset:
study of an investigational drug for the prevention of thrombosis-related events following hip replacement surgery (advance-3)

Conditions: Deep Vein Thrombosis; Pulmonary Embolism

Summary: the purpose of this study is to learn whether apixaban can prevent the blood clots in the leg (deep vein thrombosis) and lung (pulmonary embolism) that sometimes occur after hip replacement surgery and to learn how apixaban compares with enoxaparin in preventing these clots. the safety of apixaban will also be studied


Eligibility criteria:
key inclusion criteria * patients undergoing elective unilateral total hip replacement or a revision of at least 1 component of a total hip replacement. * patients who were willing and able to undergo bilateral ascending contrast venography * either sex, any race, 18 years and older key exclusion criteria * known or suspected bleeding or coagulation disorder in the patient or his or her first-degree relative * known or suspected history of heparin-induced thrombocytopenia * known coagulopathy * active bleeding or at high risk for bleeding * brain, spinal, ophthalmologic, or major surgery or trauma within the past 90 days * active hepatobiliary disease * alcohol and/or substance abuse within the past year * any condition for which surgery or administration of an anticoagulant is contraindicated * two consecutive blood pressure readings within 15 to 30 minutes with supine systolic blood pressure \>180 mm hg or supine diastolic blood pressure \>105 mm hg * clinically significant laboratory abnormalities at the enrollment visit: * hemoglobin \<10 g/dl * platelet count \<100,000/mm\^3 * creatinine clearance \<30 ml/min, as estimated by the method of cockcroft and gault * alanine aminotransferase or aspartate aminotransferase \>2\*upper limit of normal or a total bilirubin ≥ 1.5\*1 (unless an alternative causative factor such as gilbert's syndrome was identified) * need for ongoing treatment with a parenteral or oral anticoagulant (eg, subjects with mechanical valves, warfarin eligible atrial fibrillation) * current use of dextrans or fibrinolytics * treatment with medications affecting coagulation or platelet function

Keywords: prevention of deep vein thrombosis and pulmonary embolism after total hip replacement surgery
peer support for patients with diabetic foot ulcers

Conditions: Diabetic Foot Ulcer; Diabetic Wound; Diabetes Mellitus, Type 2; Diabetic Foot; Diabetes Complications; Peripheral Neuropathy

Summary: the objective of the study is to develop a peer support program that helps improve ulcer care in patients with a diabetic foot ulcer (dfu).diabetes, peripheral arterial disease (pad), foot ulceration, and subsequent amputation are unevenly patterned in terms of racial/ethnicity, socioeconomic status, health insurance, and geographic area. the project will identify opportunities to reduce health disparities among economically marginalized patients regarding dfu outcomes.

of the estimated 30 million people in the u.s. with diabetes, 34% will develop a dfu in their lifetime, and 50% of those with a dfu have concurrent pad. foot ulceration, which precedes 80% of amputations in diabetics, is associated with impaired physical function, reduced quality of life, and increased risk of death. moreover, pad, dfu, and subsequent major amputations are unevenly patterned in terms of racial/ethnic, ses, health insurance, and geographic status. more specifically, black and hispanic adults with an ischemic dfu have a higher prevalence of amputation than their white counterparts. the mechanisms of these observed disparities in amputation, beyond disease severity and comorbidities, are complex. however, evidence indicates that ulcer care (including wound care, diabetic shoe, offloading, and recognizing warning signs) is a significant challenge for low-income patients with an ischemic dfu. in addition, our team and other researchers have demonstrated how psychological, interpersonal, social, and healthcare system-level barriers limit appropriate ulcer and foot care. furthermore, our qualitative data demonstrates a high rate of psychological and interpersonal factors to diabetic foot care that cannot be ignored. clearly, there is a compelling need for innovative methods to improve dfu care that are based on health equity that led to diverse support. to address this gap, we propose a patient-centered and culturally tailored peer-pal intervention (ppi) that helps promote ulcer care in patients with a dfu, while minimizing the burden placed on system resources.

Eligibility criteria:
inclusion criteria: * age \>18 years * new ischemic dfu \<6 months * english or spanish speaking * able to provide consent exclusion criteria: * incarceration or institutionalization * unwillingness to participate in the pai program

Keywords: numbness tingling muscle weakness loss of balance shooting pain
randomised trial evaluating the benefit of a fitness tracker based workout during radiotherapy

Conditions: Bronchial Carcinoma; Esophageal Carcinoma; Tumor of the Brain; Head and Neck Cancer; Pancreas Cancer; Sarcoma; Cervix Uteri Cancer

Summary: evaluation of the impact of an activity tracker based fitness programme on the qualitiy of life after oncological therapy.

this monocentric, three-arm, randomized, controlled clinical trial evaluates the effect of an activity tracker based exercise program in cancer patients on the quality of life after oncological therapy. quality of life and the intensity of fatigue will be documented with the fact-g total score of the facit questionnaire six months after completion of radiotherapy.

Eligibility criteria:
inclusion criteria: * capacity for consent * minimum age 18 * presence of one of the following tumor diseases: bronchial carcinoma, esophageal carcinoma, tumor of the brain, head and neck cancer, pancreas cancer, sarcoma cervix uteri cancer * ecog 0-2 * indication for a radiotherapy or a radiochemotherapy with an intended treatment time of minimum 4 weeks (definitive/adjuvant/neoadjuvant) exclusion criteria: * participation in any other interventional study * radiotherapy of breast cancer * pregnancy * contraindication against physical activity/sport and others * severe cardiovascular pre-existing conditions (after myocardial infarction, apoplexy in the last 6 months, congestive heart failure nyha \> i°) * preexisting diseases with are relevantly accompanied by a limited mobility in patients (e.g. paraparesis of the lower limbs) * ecog status 3-4 * prior use of activity trackers

Keywords: fatigue activity tracker radiotherapy exercise
a mobile application based dietary self management intervention in chinese chronic kidney disease patients

Conditions: Chronic Renal Disease

Summary: this is a multi-center randomized controlled study. this study aims to investigate the acceptability and efficacy of a newly developed mobile application in the dietary management of chronic kidney disease (ckd) patients.

the prevalence of ckd has reached 10.8% in china. increasing in prevalence of other non-communicable disease such as hypertension, diabetes and obesity is contributing to this rise in ckd and end-stage renal disease prevalence. diet is a strong modifiable factor in these diseases. dietary control is also an integral part in ckd disease self management. however, the complexity in the dietary management of ckd makes it hard for patients to adequately self manage. with the development of smart phone, many mobile applications have been developed to suit the need of patients with chronic diseases. but there has been a scarce of randomized trial to support the feasibility, acceptability and efficacy of these mobile applications. our study aims to employ a newly developed dietary logging and monitoring application in the primary care setting of ckd patients to test its acceptability and efficacy in disease control. the application is developed by a multidisciplinary team in a tertiary care center. the main features include searching and logging foods, receiving realtime feedback on key nutrient intake levels and facilitating patient-care giving communication. we plan to enroll 14 tertiary hospitals and 42 secondary hospitals in 7 geographical regions in china aiming to reach participants in resource poor areas. participants will be randomized with 1 to 1 ratio to either receiving mobile application dietary intervention or usual dietary consultation. the planned intervention period is 3 months. we will monitor biochemical parameters relating to dietary control and evaluate patient-centered outcomes concerning ckd self management and control.

Eligibility criteria:
inclusion criteria: * diagnosed with ckd for more than 3 months * objective measures of kidney disease (fulfill one of the following): 1) egfr≤60ml/min/1.73m\^2; 2) proteinuria (protein + on dipstick or 24 hour urine protein\>0.3g or albumin-to-creatinine ratio (acr) \>30mg/mmol or protein-to-creatinine ratio (pcr) \>50mg/mmol); 3) imaging proven kidney disease (atrophy, stone formation, cystic kidney disease, or other structural abnormality) * having access to a mobile phone and is capable of using the dietary intervention application exclusion criteria: * can not provide history of kidney disease or can not provide laboratory result for the past 3 month * can not use a mobile phone or deemed unfit to participate by their treating nephrologist

Keywords: chronic renal disease dietary management mobile application
risk factors contributing to oral cancer in patients at dr. hasan sadikin general hospital bandung

Conditions: Oral Cavity Cancer

Summary: analytical research with a cross-sectional approach was carried out on patients diagnosed with oral cavity cancer who visited our outpatient clinic in bandung between 2023 and 2024. data were collected and analyzed using the chi-square test to determine the significance of the relationship between smoking, alcohol consumption, oral hygiene, and betel quid chewing and oral cavity cancer.

this study was conducted using a cross-sectional analytical design, allowing the assessment of the association between various risk factors and oral cavity cancer. this study was conducted at the oncology, ent, and oral surgery outpatient clinics at our hospital from january 2023 to december 2024. the inclusion criterion was a confirmed diagnosis of oral cavity cancer undergoing surgical intervention. patients with oral cancer resulting from metastasis from a primary tumor located in another organ were excluded. the control group consisted of individuals attending the hospital for non-cancer-related conditions matched by age and sex to the case group. data were collected through structured interviews using a questionnaire designed to obtain information on subject behavior, including smoking, alcohol consumption, betel quid chewing, and oral hygiene practices. medical records were reviewed to gather additional clinical information and to confirm the diagnosis of oral cavity cancer. data were analyzed using spss version 25. descriptive statistics were used to summarize the demographic and clinical characteristics of the study population. the chi-squared test was used to assess the significance of the association between risk factors and the presence of oral cavity cancer. statistical significance was set at p \< 0.05. the study was approved by the health research ethics committee (registration number dp.04.03/d.xiv.6.5/191/2024).

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of oral cavity cancer undergoing surgical intervention. exclusion criteria: * oral cancer resulting from metastasis from a primary tumor located in another organ

Keywords: oral cavity cancer risk factors smoking alcohol betel quid chewing
effect of aloe vera in the inflammation of patients with mild ulcerative colitis

Conditions: Ulcerative Colitis

Summary: the ulcerative colitis (uc) belongs to the group of diseases called inflammatory bowel disease (ibd) which is characterized by a chronic ulceration of the colon. the conventional treatment can have adverse effects and does not guarantee effectiveness in some patients requiring aggressive therapy using adjuvant therapy aloe vera has been shown to have a beneficial effect in different disease, and have an anti-inflammatory effect in uc patients. objective: measuring the effect of the consumption of 200 ml of aloe vera gel daily for a period of three months, in the degree of inflammation in patients with mild uc based on mayo scale and quantification of il-6 in the colonic mucosa.


Eligibility criteria:
inclusion criteria: * patients with confirmed diagnosis by histopathology of ulcerative colitis with mild activity level clinical, endoscopic and histological. * extent of disease: pancolitis, ulcerative proctitis and left. * being treated with 5 - aminosalicylates (5-asa). * belonging to the national institute of medical sciences and nutrition "salvador zubirán". * signed informed consent. exclusion criteria: * autoimmune diseases (lupus, hiv, cancer and any hepatitis). * another type of colitis (indeterminate, infectious drug and crohn's disease. * previous total colectomy. * body mass index less than 19.9 kg/m2 or greater than 40 kg/m2. * patients in remission histology, clinical and endoscopic. * under treatment with steroids, azathioprine, diuretics and anticoagulants. * use aloe vera or some natural therapy.

Keywords: ulcerative colitis aloe vera
role of the renin angiotensin aldosterone system in the mechanisms of transition to heart failure in abdominal obesity

Conditions: Obesity, Abdominal

Summary: r2c2 study has shown that abdominal obesity is associated with a cardiac and vascular remodelling in healthy volunteers. this remodelling is correlated with renin-angiotensin aldosterone system (raas) activation and/or systemic fibrosis. r2c2 ii study is designed to confirm the hypothesis that raas is associated with an early remodelling and implicated in the transition to cardiac failure in abdominal obesity.

follow up of abdominal obesity patients from the r2c2 cohort study.

Eligibility criteria:
inclusion criteria: * being a former member of r2c2 study, abdominal obese group. * having signed the informed consent (refusing to participate to the genetic study is not an exclusion criteria). * being affiliated to health insurance scheme. inclusion criteria of r2c2 study: * men and women aged between 40 and 65 year's old * caucasian * born or living in france for at least 10 years * presenting an abdominal obesity defined by a waist circumference \>94 cm in men and ≥ 80 cm in women, associated or not with untreated hypertension or hypertension treated for less than one year * having signed the informed consent exclusion criteria: * subjects unable to understand the information letter * subjects under supervision or guardianship * pregnant or lactating woman * a contraindication to perform mri is not an exclusion criteria.

Keywords: heart failure, abdominal obesity, raas
an acupuncture study for people at high risk for sepsis

Conditions: Sepsis

Summary: researchers think acupuncture may improve outcomes for participants with sepsis, based on laboratory studies and previous studies in people with sepsis. the purpose of this study to see whether real acupuncture can improve outcomes for participants with sepsis when compared to sham acupuncture. sham acupuncture is performed the same way as real acupuncture but will use different needles and target different sites or places on the body than real acupuncture.


Eligibility criteria:
inclusion criteria: * age 18 or older * having msk sepsis order-set placed within the previous 48 hours exclusion criteria: * the study principal investigator will review the medical record again prior to enrollment to exclude non-sepsis patients (even though the placement of sepsis order set already screens out such patients, subsequent clinical development after sepsis order set placement may generate new information that deems the patient not septic.) * admitted to icu before being approached for consenting * having an implanted medical device, such as a pacemaker or implantable cardioverter-defibrillator (icd), with which electroacupuncture * unable to obtain informed consent due to a participant's mental status and absence of an individual authorized to give consent on the participant's behalf * the patient is on an interventional clinical trial and its principal investigator does not give approval to enrollment to this study (e.g. genomic profiling, biospecimen, or observational studies do not require pi approval).

Keywords: sepsis acupuncture memorial sloan kettering cancer center 24-062
effects of pulmonary diseases and their treatment on cardiac function

Conditions: COPD; Bronchial Asthma; Idiopathic Pulmonary Fibrosis

Summary: while the bidirectional relationship between the lung and the right heart are well studied, the cardiopulmonary interactions between the lung and the left heart are largely unresearched and not well understood. however, in recent years, there is a growing evidence that partially explains the bidirectional interaction between copd and left heart. systemic inflammation with multiorgan involvement is thought to play a role in copd as a systemic disease. some therapeutic approaches to copd also appear to influence these cardiopulmonary interactions. while understanding these interactions is very important for clinicians, scientific data are scarce. cardiac magnetic resonance imaging (cardiac mri) is the gold standard for assessing cardiac function and dimensions as well as myocardial inflammation. despite this excellent suitability of cardiac mri for the assessment of cardiovascular function, only few studies have investigated cardiac function and myocardial structure in patients with pulmonary disease using cardiac mri. such a study is therefore very important for understanding the effects of pulmonary disease and its management on the heart. the objective is to determine cardiac function in patients with pulmonary disease and to analyze the cardiovascular effects of the treatment of the pulmonary disease. specifically, the following will be studied: * using cardiac mri: cardiac function and volumes and indications of myocardial fibrosis and edema in patients with chronic pulmonary disease at the time of first diagnosis. * the vascular function of pulmonary arteries in these patients, also using cardiac mri * the relationship between pulmonary function parameters and cardiac dysfunction to identify patients at increased risk, if applicable. * echocardiographic assessment of left heart including strain analysis. * the course of these cardiovascular parameters (using cardiac mri and echocardiography) 3-6 months after initiation of guideline-based therapy for pulmonary disease.


Eligibility criteria:
inclusion criteria: * patients with chronic lung disease requiring treatment (copd, asthma, or pulmonary fibrosis). * age \> 18 years * informed consent to participate in the study will sign exclusion criteria: * individuals who are not fully capable of giving consent and understanding the nature, significance and scope of the study. * patients with contraindications to mri examination (eg, pacemaker, severe claustrophobia) or to contrast medium use (severe renal insufficiency or glomerular filtration rate \<30 ml/min, known gadolinium contrast medium allergy) * patients with atrial fibrillation or other significant cardiac arrhythmias that interfere with cardiac mri * pregnancy and lactation
validation and reliability of iris cameras in mucopolysaccharidoses

Conditions: Mucopolysaccharidoses

Summary: to assess the reliablity and validity of 2 new iris cameras in the assement of corneal opacification in mucopolysaccharidoses

the mucopolysaccharidoses (mps) are a group of disorders resulting from accumulation of glycosaminoglycans within various tissues including the eye. this can result in visual loss from corneal opacification. the assessment of corneal opacification is extremely subjective and based on a clinician grading this during slit lamp examination. there can be a significant variability and can prove problematic particularly in clinical trials assessing if corneal opacification is affected by potential new treatments. the use of imaging could facilitate objective measurement of corneal clouding. a previous study using an iris camera and image analysis to provide a corneal opacification measure score (com score) demonstrated that it can be used in children with mps, however it still had limitations- as the system is fully automated, if certain conditions are not met an image is not captured. this can be an issue in younger children who may not be cooperative, and limited its use in younger patient populations. it is anticipated that these limitations can be addressed by employing a newer iris camera (irishield mk2120ul). the new camera's advantage is that it takes images monocularly, therefore only the eye under question needs to be aligned. we will also assess a new manual system (ircamnew) which takes images whenever the shutter is manually pressed. this would be useful in children who cannot fixate with one eye, and can also be used when the child is examined under general anaesthetic which is commonly done in paediatric ophthalmology. if proven to be comparable to the existing iris camera (iriscamorig) in terms of validity and reliability, the added benefits of these new iris cameras can open its use in a wider range of patient populations - for instance, in paediatric clinical trials-, as well as allowing longitudinal tracking of corneal clouding from early childhood well into adulthood.

Eligibility criteria:
inclusion criteria: * any patient aged 0-100 with mps type i, type iii, type iv and type vi. type vii mps patients may also be eligible. for the control group - participants of any age currently being followed at mreh that have an eye condition unrelated to the cornea as established by clinical examination. exclusion criteria: * mps ii