Kornimate/medical-research-clean huggingface dataset:
venous ulcer treatment with foam versus conservative treatment

Conditions: Venous Ulcer

Summary: the venous ulcer due to venous insufficiency causes an important morbility to those people suffering from this condition. most of therapies available under the obligatory health plan (pos, acronym in spanish) to date cover the cleaning of the ulcerous lesion and its medical handling using saline solutions, topical antibiotics and elastic dressings, implying an important intake from health resources due to its chronicity and the delay in ulcers healing, which usually takes periods ranging from 6 months to several years. therapeutical alternatives, which can guarantee optimal, fast and persistent in time healings, should be identified. the aim of this study is to determine the percentage of healing of active venous ulcers (using a clinical, etiological, anatomic and physiopathologic classification (ceap), c6) following ultrasound-guided foam sclerotherapy of superficial venous reflux in patients with chronic venous ulceration after six months from the intervention, compared with conservative medical handling. the investigators expect that the ultrasound-guided foam sclerotherapy of superficial venous reflux will diminish the time of ulcer healing compared with standard handling.

to determine healing rates following ultrasound-guided foam sclerotherapy (ugfs) of superficial venous reflux (svr) in patients with open (clinical,etiologic, anatomic and pathophysiologic (ceap) classification, c6) chronic venous ulceration ( cvu) in a randomised clinical trial of foam sclerotherapy for patients with venous ulcer

Eligibility criteria:
inclusion criteria: * presence of venous ulcer confirmed by ceap c6 * chronic venous ulcer present for at least 4 weeks * ankle-arm index greater or equal to 0.8 mmhg exclusion criteria: * severe hepatic, cardiac or pulmonary disease * deep venous thrombosis * active participation in other clinical trials

Keywords: ultrasound-guided foam sclerotherapy; chronic venous ulcers
the brain stimulation and physical therapy study

Conditions: Fall; Gait, Unsteady; Aging; Accidental Fall

Summary: this pilot work will determine the feasibility of tdcs intervention as an effective adjunct intervention to pt aimed at improving gait, balance, and mobility in older adults at risk of falling.

falls are correlated with both physical and cognitive declines in older adults. recurrent fallers and those at high risk of falls are often referred to physical therapy (pt) for gait and balance training. although physical therapists are aware of the importance of cortical control of gait and balance, there is no available tool to directly yet non-invasively intervene brain in the clinical setting. transcranial direct current stimulation (tdcs) is a noninvasive and safe mean of modulating the excitability of specific brain regions and their connected neural networks. our group and others have shown that tdcs intervention designed to facilitate the excitability of the left dorsal lateral prefrontal cortex (dlpfc) improves numerous aspects of executive function related to mobility in older adults. however, no studies to date have assessed the feasibility and effectiveness of applying tdcs as an adjunct to pt to improve gait and balance within the geriatric rehabilitation setting. this study aims to 1) assess the feasibility of implementing tdcs prior to each of their first 10 pt sessions, and 2) gather estimates of variability in outcomes related to gait, balance, cognition, and quality of life over time within older adults referred to pt for recurrent falls.

Eligibility criteria:
inclusion criteria: * ages 65 years old and above * admitted to physical therapy for gait and balance training due to the high risk of falls exclusion criteria: * inability to stand or walk unassisted for 60 seconds * severe cognitive impairment defined as a montreal cognitive assessment (moca) score \< 18 * any unstable medical condition * any unstable psychiatric co-morbidity including major depressive disorder, schizophrenia or psychosis * active cancer for which chemo/radiation therapy id being received * significant vision and hearing problems that cannot be corrected with visual and hearing aids * contraindications to tdcs, including seizure within the past two years, use of neuro-active drugs, the risk of metal objects in the brain, implanted medical devices, or the presence of dermatological conditions such as eczema on the scalp.
geriatric intervention in frail elderly patients with colorectal cancer

Conditions: Colorectal Neoplasms

Summary: this is a randomized, controlled trial on frail elderly patients (aged 65+) with colorectal cancer. the patients will be randomized into two groups. the control group will receive standard surgical treatment. the intervention group will in addition go through a preoperative comprehensive geriatric assessment. the assessment will include evaluation of co-morbidity and medication, social status, nutritional status, cognition, depression and physical performance. this assessment will form basis of an individualized perioperative intervention. the main aim of the study is to see if the number of postoperative complications in this group can be reduced by a perioperative geriatric intervention. a study of inflammation markers in serum will also be performed, with focus on identifying potential biological frailty markers.


Eligibility criteria:
inclusion criteria: * age 65+ * elective surgery for colorectal cancer * frail exclusion criteria: * acute surgery * not able to consent * does not consent with registration

Keywords: geriatric assessment perioperative care colorectal neoplasms frail elderly
phase ⅱ study of adductor canal block with hr18034 for postsurgical pain management in tka

Conditions: Postoperative Pain Management in Total Knee Arthroplasty

Summary: phase ⅱ, randomized, double-blind, comparator-controlled study to evaluate the efficacy, safety and pharmacokinetics of single injection adductor canal block with hr18034 for postoperative pain management in total knee arthroplasty compared with ropivacaine.


Eligibility criteria:
inclusion criteria: 1. able and willing to provide a written informed consent 2. scheduled to undergo primary unilateral total knee arthroplasty under general anesthesia. 3. male or female，aged ≥ 18 years 4. body mass index (bmi) ≥ 18 kg/m2 5. american society of anesthesiologists (asa) physical status classification ⅰ\~ⅲ exclusion criteria: 1. subjects with deformity of the involving operative limb, or other neuropathy 2. subjects with a history of new myocardial infarction or unstable angina within 6 months prior to randomization; 3. subjects with a history of ischemic stroke or transient ischemic attack (tia) 4. subjects with a history of mental system diseases and cognitive dysfunction 5. combination of other pain conditions that may affect postoperative pain assessment 6. persistent or recurrent nausea and/or vomiting due to other etiologies, including, but not limited to gastric outlet obstruction, hypercalcemia, or active peptic ulcer 7. subjects with a history of deep vein thrombosis-related disease 8. clinically significant abnormal clinical laboratory test value 9. allergic to a drug ingredient or component 10. use of any of medications, which affect drug metabolism or analgesia evaluation, within 5 half-lives or as specified prior to the study surgical procedure 11. history of alcohol abuse or prescription and/or illicit drug abuse 12. pregnant or nursing women 13. no birth control during the specified period of time 14. participated in clinical trials of other drugs (received experimental drugs) 15. the inestigators determined that other conditions were inappropriate for participation in this clinical trial
biofilm composition as a predictive biomarker for prosthetic joint infection

Conditions: Joint Infection

Summary: prosthetic joint infection (pji) represents one of the most common reasons for failure among hip and knee prostheses, with an incidence of around 1-2%. infection can occur early (within days of surgery) or late (over a year after surgery), and no specific early markers for infection onset exist. given the significant costs to the nhs for corrective revision surgery, the added suffering and risk to patients from surgery, and the risk of enhancing antimicrobial resistance through the use of broad-spectrum antibiotics, a more specific predictive test for early onset of infection is required.

over 80% of human infection is estimated to be a result of biofilm formation. biofilms are an accumulation of microorganisms (predominantly bacteria) on a surface, resulting in a functional community which provides antibiotic resistance and a beneficial environment for the growth of pathogenic species that would otherwise be removed by the body's defences. the use of medical implants in modern medicine has become an increasingly common occurrence, with hip and knee arthroplasty accounting for a large number of medical implant surgeries. unfortunately, infections frequently result in failure of the implanted device (around 1-2% for knee and hip arthroplasty), requiring extensive revision surgery. currently, no predictive biomarkers for pji exist, and diagnostic tests require infection to have already taken hold and may often be highly invasive. research conducted by the nih suggests that accumulation of bacteria (known as biofilms) may account for over 80% of microbial infections in the human body and have been shown to develop on medical implants, such as those used in hip and knee arthroplasty. bacterial biofilms on medical implants are poorly understood, making treatment very complex. the investigators aim to identify early predictive biomarkers for pji based on assessment of the biofilm structure on implants removed in revision surgery, either as a result of pji or due to aseptic causes such as mechanical failure. the investigators will explore biofilm formation on hip joint prostheses using next generation sequencing (ngs) and 3d phase-contrast x-ray microscopy, and will compare bacterial diversity and biofilm structure between infected and non-infected samples to answer three main questions: 1. can the investigators accurately describe the characteristic microbiome of hip joint prosthetic biofilms? 2. is there a distinct characteristic microbiome or biofilm structure associated with pji? 3. can the investigators detect such characteristic biofilm members as biomarkers in simple blood tests?

Eligibility criteria:
inclusion criteria: * male or female, aged 18 years or above. * due to undergo prosthetic revision surgery for any reason identified by the clinical team willing to provide informed consent exclusion criteria: * participant lacking capacity to give informed consent * any other clinical reason the participant should not be included in the study- at the discretion of the clinical team
cp009 synergoss pxx observational

Conditions: Mouth, Edentulous

Summary: the device under investigation is synergoss, a ce (european community ce) marked device. synergoss is a granulated bone graft intended for use in dental applications. it is composed of a ceramic composite of hydroxihapatite and tricalciumphosphate in granules, coated with a dedicated collagen coating (porcine origin), obtained by means of collagen crosslinking on the ceramic granule surface. the purpose of the study is to confirm the foreseen efficacy and tolerability of synergoss, a synthetic dental graft coated with collagen. for this observational study, we will enroll patients that already received a surgical intervention for sinus augmentation/ socket preservation by means of synergoss to maintain and regenerate bone before installation of endosseous titanium implants to support a fixed prosthesis. patients will be enrolled just before they receive the surgery for the installation of endosseous titanium implants, about 24 weeks after the first surgery for the implant of synergoss. the primary hypothesis is to demonstrate that synergoss consistently obtains the foreseen clinical benefit as declared in the technical file. the secondary hypothesis is to demonstrate that synergoss side effects and risks match those declared in the technical file. the study design is a * national * monocentric * prospective: the participants are identified and then followed forward in time. * observational: participants that have recently received the grafting with synergies as part of normal and foreseen clinical procedures are enrolled in the study when they receive surgery for titanium implant placement and observed over time, with no substantial intervention other than the foreseen clinical treatment


Eligibility criteria:
inclusion criteria: * • received in the past 16-24 weeks a bone graft for sinus lift or socket preservation with the id * capable of giving a valid informed consent * asa 1, asa 2 * agrees to return for follow-up visits up to 2 years exclusion criteria: * • uncontrolled diabetes * patients with psychiatric diseases * neoplasic, immunodepressive, renal or liver major illnesses * local radiotherapy * major bruxism or major differences in the maxilla or mandubilar area * drug or alcohol abuse * major bone metabolism disorders * heavy smokers (more than 10/day) * bisphosphonate treatment of major ostheoporosys or bone neoplasia * pregnant women * sinus illnesses * contraindications to implant supported prostheses * patients asa 3,asa 4, asa5 * surgical intervention contraindications
exercise preconditioning and breast cancer cardiotoxicity

Conditions: Breast Cancer

Summary: the purpose of this study is to determine whether a supervised exercise-training program, initiated prior to chemotherapy induction (pre-conditioning) and continued throughout chemotherapy treatment, can preserve short- and long-term cardiovascular performance, skeletal muscle function, cognitive ability and quality of life better than current standard or care recommendations for exercise during chemotherapy.

the primary aim of this study is to determine the efficacy of a novel, high-intensity aerobic interval exercise preconditioning protocol to ameliorate anthracycline-mediated cardiac and skeletal muscle toxicity in women with breast cancer undergoing de novo chemotherapy. research design: women with breast cancer scheduled to undergo de novo chemotherapy with anthracyclines will be enrolled. qualified patients will be randomized to either 1) a high-intensity interval exercise group, or 2) an attention-control group. supervised exercise training will be carried out at the mayo clinic cardiac rehabilitation center in arizona on cycle ergometers using electrocardiogram (ekg) telemetry. patients in the high-intensity interval exercise group will perform four, 4-min intervals at 85-90% peak heart rate (phr), separated by 3 min at 50% phr. each training session will begin with a 10-minute warm-up at 50% of phr and end with a 5-min cool down at 50% phr. the attention-controls will receive counseling consistent with standard of care regarding physical activity during chemotherapy. attention-control group will receive a weekly phone call to maintain physical activity during chemotherapy and compliance will be verified using physical activity diaries and pedometers. treatment for each group will commence 1-week prior to chemotherapy induction. the first dose of chemotherapy will be given within 16-18 hours of the last bout of exercise. high-intensity intermittent exercise (hiie) training will be continued throughout four, 2-week cycles of chemotherapy (total training time = 9 weeks, 3 days/week).

Eligibility criteria:
inclusion criteria: * subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent * subjects will have been recently diagnosed with breast cancer (stage i, ii or iii) * subjects must be scheduled by their oncologist to undergo anthracycline based chemotherapy (doxorubicin and cyclophosphamide) in the neoadjuvant/adjuvant setting exclusion criteria: * unstable angina * myocardial infarction in the past 4 weeks * uncompensated heart failure * new york heart association class iv symptoms * complex ventricular arrhythmias * medical orthopedic conditions precluding stationary cycling * medical conditions precluding neuropsychological assessment * symptomatic severe aortic stenosis * acute pulmonary embolus * acute myocarditis * untreated high-risk proliferative retinopathy * recent retinal hemorrhage * uncontrolled hypertension * sodium and/or potassium ≥ grade 2 * pregnant women

Keywords: chemotherapy exercise
comparison effectiveness of rectal misoprostol & intravenous tranexamic acid reducing hemorrhage in myomectomy

Conditions: Hemorrhage, Surgical; Myoma;Uterus; Effect of Drug; Postoperative Hemorrhage; Postoperative Complications

Summary: fibroids are the most commonly encountered tumors in the female reproductive system. in patients, fibroids most often lead to abnormal uterine bleeding and the resulting anemia. in some cases, they can cause infertility or habitual abortions. another complaint caused by fibroids is pain due to pressure and effects on adjacent organs. very large fibroids can lead to abdominal swelling. therefore, if a patient becomes symptomatic due to fibroids, myomectomy or, if necessary, hysterectomy is required. because fibroids have a significant blood supply, there is a high risk of intraoperative bleeding and related complications. additionally, the most common complication in these patients after the operation is bleeding. in many of these patients, intraoperative or postoperative blood transfusions are performed. if bleeding cannot be intervened early in these patients, hemodynamic instability, shock, coagulopathy, and, in the final stage, death can occur due to hemorrhage. therefore, both intraoperative and postoperative bleeding control is of vital importance in patients undergoing myomectomy.

in this study, data of patients admitted with a diagnosis of uterine fibroids to the department of obstetrics and gynecology, women's health and obstetrics (eşh) between september 1, 2022, and sempember 1, 2024, who underwent myomectomy (either laparotomic or laparoscopic), will be collected. the parameters to be examined in the research are as follows: 1. patients' postoperative 1st, 2nd, and 6th-hour vital signs (pulse rate, systolic and diastolic blood pressure, temperature, oxygen saturation). 2. shock indices. 3. hemogram and hematocrit values at 6-24 hours postoperatively. 4. duration of the surgery. 5. adverse effects experienced by the patients. 6. additional treatments administered. 7. whether blood transfusion was performed or not. in this study, the g-power analysis program was used to determine the minimum sample size, taking into account a 10% margin of error. according to the analysis results, the minimum number of patients to be included in the study for a total of 75 patients across 3 groups was determined. statistical analysis of the data obtained in the study will be conducted using the spss statistics 22 software package. a 95% confidence interval will be calculated for each variable, and results will be considered statistically significant for p \< 0.05.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age * laparotomic myomectomy surgeries * laparoscopic myomectomy surgeries exclusion criteria: * identifying missing or suspicious data related to the patient * administering both intraoperative and postoperative medications to the patient

Keywords: myoma uteri fibroids hemmorhage prostoglandinf2α tranexamic acid
testing the efficacy of an online social network intervention to increase social support for physical activity

Conditions: Cardiovascular Disease; Cancer; Obesity

Summary: this study was designed to determine whether participation in an online social network intervention increases perceived social support for physical activity versus a minimal education control group by conducting a randomized controlled trial with 140 female undergraduate students. the investigators hypothesize that participants in the physical activity centered online social network intervention group will have greater increases in perceived social support for physical activity compared to minimal web based physical activity education controls.


Eligibility criteria:
inclusion criteria: * female * under the age of 25 * currently enrolled full time or part time student at the university of north carolina at chapel hill * classified as an undergraduate * answers no to all questions on an exercise risk factor questionnaire (par-q) or is cleared in writing by a physician to participate in an independent exercise program * a score of less than 3 on the scoff eating disorders questionnaire * less than 30 minutes per day of self reported moderate or vigorous physical activity * regular facebook use as defined by self reported owning of an account and use of at least 30 minutes per day * willing to provide informed consent * willing to participate in the intervention * literate in the english language.
virological suppression in hiv positive patients involved in a novel standardized adherence protocol

Conditions: Hiv

Summary: this study will look at virologically suppression of patients with hiv who receive pharmacist or case management care.


Eligibility criteria:
inclusion criteria: * patients with a baseline viral load \> 200 copies/ml * patients who agree to program enrollment * patients ≥ 18 years of age exclusion criteria: * pregnant women * adults unable to consent * prisoners
the holding study: feeding analgesia in preterm infants

Conditions: Pain

Summary: the purpose of this study is to compare the effects of mothers' skin-to-skin holding during feeding via a soother trainer with the effects of pacifier sucking on preterm infant biobehavioural responses during and immediately after a painful procedure hypothesis: 1. when held by their mothers during blood collection, preterm infants will show less pain reaction than when sucking on a pacifier. 2. following holding during the blood collection, mothers will find no differences in their infants' feeding ability.

research method: in a between subjects, randomized design, 20 stable preterm infants born between 30-35 weeks gestational age will be studied. infants will be randomized to one of two interventions which will take place during blood collections that are required for clinical management. for the standard care condition, infants will remain in their isolettes and will be positioned in prone and given a pacifier to suck on throughout the blood collection. for the holding condition, infants will be held skin-to-skin by their mothers and given breast milk using a soother trainer during the blood collection.

Eligibility criteria:
inclusion criteria: * born between 30-35 weeks gestational age * mother has fluent english exclusion criteria: * cns injury * congenital anomaly * active infection * has had no surgeries or analgesics/sedatives in last 72 hours * history of maternal drug exposure

Keywords: pain response