Kornimate/medical-research-clean huggingface dataset:
mineral and enzyme deficiency diseases associated with nutritional diseases in society

Conditions: Nutrient Deficiency

Summary: nutritional deficiency disease is a disease caused by nutritional deficiencies, including macronutrients and micronutrients. macronutrient diseases are diseases caused by deficiency of protein, fat and carbohydrates. this deficiency will usually show clinical symptoms that directly affect nutritional status. this study aims to study and examine mineral intake, dietary patterns of research subjects, mineral and enzyme levels, and soil condition data. the number of research subjects to be taken was 180 subjects with 90 research subjects coming from mothers who had healthy children and 90 research subjects came from mothers who had stunted children or other nutritional disorders. the research stage will run after going through the inclusion of research subjects, namely mothers who have healthy children and mothers who have nutritionally deficient children, aged 20-40 years. the research stage consisted of two stages. the statistical analysis used is to use the anova test, which will then compile a manuscript.

this study aims to study and examine mineral intake, dietary patterns of research subjects, mineral and enzyme levels, and soil condition data. the number of research subjects to be taken was 180 subjects with 90 research subjects coming from mothers who had healthy children and 90 research subjects came from mothers who had stunted children or other nutritional disorders. the research stage will run after going through the inclusion of research subjects, namely mothers who have healthy children and mothers who have nutritionally deficient children, aged 20-40 years. the research stage consisted of two stages. the statistical analysis used is to use the anova test, which will then compile a manuscript. this research is a case control study, with primary data collection, is a laboratory clinical trial study on the subject of mothers who have children aged 2-3 years, aged 20-40 years. the number of research subjects to be taken was 180 subjects with 90 research subjects coming from mothers who had healthy children and 90 research subjects came from mothers who had stunted children or other nutritional disorders. the research stage consisted of two stages, the first stage was the initial screening of the primary data of the research subjects, namely by analyzing food intake including mineral intake data, the diet of the research subjects, mineral and enzyme levels, and data on soil conditions in the area. the second stage was to analyze the relationship between the existing variables so that the most significant relationship was seen between the differences in diet, mineral content, enzyme levels, and soil content between the two groups. the statistical analysis used was to use the anova test.

Eligibility criteria:
inclusion criteria: * mothers who had healthy children exclusion criteria: * mothers who have healthy children and mothers who have nutritionally deficient children

Keywords: nutritional deficiency macronutrient mineral enzyme stunting
educational physiotherapy in haemophilia

Conditions: Haemophilia

Summary: although arthropathy is a serious problem in patients with hemophilia due to the associated morbidity and incapacity, to the best of the investigators knowledge, no studies have looked at the effect of educational physiotherapy for its clinical improvement. this contribution presents the results of educational physiotherapy program applied for 15 weeks with home exercises - in patients with hemophilic arthropathy. after treatment, experimental group showed improved a significant reduction of pain, and best quality of life al illness behaviour. during treatment no patient showed elbow haemarthrosis, which underlines the safety of this physiotherapy program.


Eligibility criteria:
inclusion criteria: * patients diagnosed with hemophilia a or b * patients over 18 years * patients with hemophilic arthropathy with at least 1 involved joint (elbow, knee or ankle) * having signed the informed consent document. exclusion criteria: * patients diagnosed with other congenital bleeding disorders (i.e. von willebrand disease) * patients who developed antibodies to fviii or fix (inhibitors) * those not able to ambulate as a result of hemophilic arthropathy or any other disability

Keywords: hemophilia educational physiotherapy pain quality of life illness behaviour elbow
effect of soy intake on cardiovascular disease biomarkers in subclinical hypothyroid participants

Conditions: Cardiovascular Disease; Subclinical Hypothyroid

Summary: the purpose of this study is to help the researchers understand if using a soy supplement impacts cardiovascular disease risk factors in patients with subclinical hypothyroidism.

this pilot trial is a double blind, randomized, parallel arm trial. eighty participants with subclinical hypothyroidism will be randomized to consume either soy protein isolate or milk protein isolate for 8 weeks.

Eligibility criteria:
inclusion criteria: * patients with subclinical hypothyroidism (otherwise healthy volunteers) * adults aged 25 - 70 yrs. * willing to avoid consumption of soy/other isoflavone containing foods (i.e. some snack bars) during the study. * willing to avoid consumption of dietary (other than multivitamin) and herbal supplements during the study. exclusion criteria: * taking drugs that interfere with thyroid function * planning pregnancy in the next 6 months * taking drugs that lower lipids, blood pressure, or sensitize insulin * regular consumption of soy products (\>20 g/wk) * consumption of soyfoods within 90 days prior to enrollment. * known history of soy or milk allergy or intolerance. * taking antibiotics during the intervention * active viral infections such as human immunodeficiency virus (hiv) positive or hepatitis

Keywords: isoflavone cvd soy intake subclinical hypothyroid
panic disorder and cardiac risk

Conditions: Panic Disorder

Summary: the reason for increased cardiac mortality in panic disorder has not been precisely identified, but possibly is due to chronic activation of the cardiac stimulant (sympathetic) nerves, which may predispose the individual with panic disorder to disorders of cardiac rhythm and coronary artery spasm. the uniqueness of this study lies in its comprehensive evaluation of a psychobiological approach to the treatment of panic disorder using change in biological, behavioural and psychological variables as criteria for efficacy. 50 patients aged between 18 and 60 years will be recruited; both males and females. they will be treated with either cognitive behavioural therapy (cbt) or ssri (selective serotonin re-uptake inhibitor) antidepressants or a combination of both. this project will firstly compare individuals with panic disorder who demonstrate abnormal brain transmitter (noradrenaline, serotonin) with those who demonstrate normal activity of these neurotransmitters, on interoceptive accuracy for changes in sympathetic nervous system arousal. it is predicted that individuals who demonstrate abnormal activity of these neurotransmitters will also demonstrate enhanced interoceptive ability to detect changes in arousal levels. secondly, this project will evaluate the effects of a psychobiological treatment approach to panic disorder involving a combination of cbt and ssri. this approach will be compared to the effects of both these interventions alone on a comprehensive array of measures related to panic disorder. it is predicted that the combined approach will be the most effective intervention on behavioural, psychological and biological variables, and cardiac risk. we will also be able to assess whether changes in panic disorder severity are associated with changes in interoceptive accuracy.


Eligibility criteria:
inclusion criteria: * panic disorder exclusion criteria: * comorbid heart disease * comorbid significant psychiatric illness * significant suicide risk * hiv/aids hepatitis b/c

Keywords: panic disorder cardiac risk
postprandial effects of high-fat meals with different dairy products on lipid metabolism and inflammation

Conditions: Healthy; Overweight; Obesity

Summary: the aim of this project is to elucidate how high-fat meals with different kinds of dairy products affect postprandial responses of lipid metabolism and inflammatory markers in healthy and obese subjects.


Eligibility criteria:
inclusion criteria: * the study will include both men and women aged 18-70 years with the aim of an even age and gender balance. * participants in the healthy group will need to have a body mass index (bmi) between 18.5 - 24.9 kg/m2 and a waist circumference (wc) of \<94 cm for men and\<80 cm for women. * participants in the obese group will need to have a bmi of ≥25 kg/m2 and a waist circumference of ≥94 cm for men and ≥80 cm for women. * all subjects must be willing to eat three slices of bread with a dairy product and jam as breakfast. exclusion criteria: * bmi \ 25 kg/m2 in the healthy group and \<25 kg/m2 in the obese group * wc ≥94 for men and ≥80 cm for women in the healthy group, \<94/80 cm for men/women in the obese group * weight change of ± 5 % of body weight in the last three months * tg ≥1.3 mmol/l in the healthy group * crp \>10 mg/l * total cholesterol \>6.1 mmol/l for subjects 18-29 years, \>6.9 mmol/l for subjects 30-49 years and \>7.8 mmol/l for subjects ≥50 years old * blood pressure \>160/100 mm hg * comorbidities including diabetes type i and ii (blood glucose ≥7 mmol/l fasting), coronary heart disease, haemophilia, anaemia (hemoglobin \ 4 mu/l) * pregnant or lactating * allergic or intolerant to gluten, milk protein and/or lactose * use of medications affecting lipid metabolism or inflammation * unwilling to seponate omega-3 rich supplements four weeks prior to screening and during the study period * hormone treatment (stabile dose of contraception or thyroxin for the last three months excepted) * blood donation two months prior to test day 1 or during the study period * tobacco smoking * excessive regular alcohol consumption (\>40 grams per day) or prior to the test day

Keywords: healthy volunteers obese volunteers
haic in combination with immune checkpoint inhibitors and tyrosine kinase inhibitors for advanced hcc

Conditions: Hepatic Arterial Infusion Chemotherapy; Tyrosine Kinase Inhibitor; Immune Checkpoint Inhibitors; Hepatocellular Carcinoma (HCC)

Summary: the purpose of this study is to evaluate the safety and efficacy of hepatic arterial infusion chemotherapy (haic) in combination with pd-1 inhibitors and lenvatinib in patients with different tumor burden advanced-stage hepatocellular carcinoma (hcc) with portal vein tumor thrombus (pvtt).


Eligibility criteria:
inclusion criteria: 1. has a diagnosis of hcc confirmed by radiology, histology, or cytology; 2. barcelona clinic liver cancer (bclc) stage c with the presence of portal vein tumor thrombus; 3. has not received any previous systemic therapy for hcc (including chemotherapy, molecularly targeted therapy, immunotherapy); 4. both tkis and icis patients received only include marketed drugs but are not limited to hcc approval; 5. haic was performed after the first tkis/ icis treatment or before treatment; 6. received at least 2 cycles of haic or icis treatments； 7. has repeated measurable intrahepatic lesions; 8. child-pugh class a or b. exclusion criteria: 1. patients who took systemic anti-tumor treatments before the combination therapy; 2. with other malignant tumors; 3. unable to meet criteria of combination timeframe described above.
ankle athletic taping fatigue after a standard tennis warm up

Conditions: Ankle Injuries

Summary: identify, quantify and compare the fatigue caused in two ankle athletic tapes after the completion of a tennis warm-up.


Eligibility criteria:
inclusion criteria: * there have been no ankle injury in the last 6 months (defined as any problem ankle injury that limited normal activity for more than 48 hours). * not having any neurological, circulatory or degenerative disease or to upset the balance in the lower limbs. * not having had any fractures or have undergone surgery on the lower limbs. * no experience pain in the ankle at the time of the study. exclusion criteria: * allergy to any of the materials used bandage * suffer an injury before taking the last measurement that prevented them from developing their sport normally.

Keywords: athletic tape tennis warm-up exercise
a single dose study of pf-04620110 in overweight and obese, otherwise healthy volunteers

Conditions: Overweight

Summary: pf-04620110 is a novel compound proposed for the treatment of type 2 diabetes mellitus. the purpose of this study is to characterize the safety, tolerability, pharmacokinetics and pharmacodynamics following a single oral dose.


Eligibility criteria:
inclusion criteria: * healthy male and/or female subjects between the ages of 18 and 55 years * body mass index (bmi) of approximately 27 to 35 kg/m2; and a total body weight \>50 kg (110 lbs) exclusion criteria: * evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing).

Keywords: single ascending dose study in overweight subjects
single oral dose of dexamethasone versus five days of prednisone in adult asthma

Conditions: Asthma; Reactive Airway Disease

Summary: this study seeks to compare the effectiveness of a single dose of oral dexamethasone versus 5 days of oral prednisone in the treatment of mild to moderate asthma exacerbations to prevent relapse with an unscheduled return visit to a health care provider for additional asthma treatment within 14 days. the investigators hypothesize that the two treatments will be equally effective in relapse prevention.

dexamethasone and prednisone are both systemic corticosteroids. the study will compare a single dose of oral dexamethasone to 5 days of oral prednisone in the treatment of asthma. oral corticosteroids are commonly prescribed following an asthma exacerbation as it has been demonstrated that these medications prevent relapse. oral prednisone is the most common corticosteroid prescribed for asthma relapse prevention. the half life is around 4 hours and is typically prescribed for minimally 5 days. the study is evaluating the efficacy of a single dose of dexmethasone. the drug's efficicacy has been shown to be longer acting and up to 72 hours. a single dose would eliminate the need for a prescription for a drug like prednisone to hopefully improve compliance.

Eligibility criteria:
inclusion criteria: * age 18-55yo * history of asthma * requires \> 1 albuterol nebulizer * valid phone number exclusion criteria: * declines participation * past allergic reaction to corticosteroids * use of oral steroids in the last 2 weeks * pregnant * history of copd, pulmonary fibrosis, cystic fibrosis, or other chronic lung disease * history of hiv * history of chf * history of diabetes mellitus * active chickenpox (varicella) or shingles (herpes zoster) * active tb * requires admission to the hospital * requires immediate airway intervention

Keywords: relapse corticosteroids
evaluation of a proactive clinical management and early diagnosis of arrhythmias in patients with heart failure and non severely reduced left ventricular function through a telemonitoring system

Conditions: Heart Failure; Arrhythmias, Cardiac

Summary: vasco trial is a no profit, multicenter, international, prospective, randomized study designed to evaluate the clinical benefits of a remote monitoring management based on ilr vs standard practice in patients with high risk of cardiac arrhythmias, heart failure and left ventricle ejection fraction (lvef)\> 40% .the study will enroll about 331 patients (221 in the ilr group and 110 in the in-hospital follow-up group).


Eligibility criteria:
inclusion criteria: * patients with heart failure, lvef\> 40% who report episodes of palpitations. * over 18 years of age * ability to provide informed consent for registry participation and be willing and able to comply with the protocol described evaluations exclusion criteria: * subject who is, or is expected to be unavailable for follow-up * pregnancy * medical contraindications for ilr implantation * patients with pmk / icd or with indication for icd / pmk implantation * cardiovascular events / myocardial revascularization in the previous three months * patients already on oral anticoagulant treatment * patients who do not want to use the telemonitoring system * presence of other recognized indications to ilr (unexplained syncope, cryptogenic stroke/tia, transient loss of consciousness and recurrent falls)
correlation between body composition and pathologic grade/prognosis in gep-nens: a retrospective study

Conditions: Neuroendocrine Tumors

Summary: the goal of this observational study is to learn about the value of body composition as predictors of pathological grading and prognosis in patients with gastroenteropancreatic neuroendocrine neoplasms. the main question it aims to answer is: does body composition affect the pathological grading and prognosis of patients with gastroenteropancreatic neuroendocrine tumors? participants with gastroenteropancreatic neuroendocrine neoplasms will answer questions about their physical condition during follow-up visits.

objectives to explore the value of body composition parameters (bcps) as predictors of pathological grading, prognosis in patients with gastroenteropancreatic neuroendocrine neoplasms (gep-nens). methods this retrospective multicenter analysis enrolled gep-nens patients pathologically confirmed from three institutions between 2015 and 2024. the volume of skeletal muscle and abdominal fat tissue was calculated based on ct scans at diagnosis. univariate and multivariate logistic regression analyses were used to identify the relationships between bcps and the pathological grade. the kaplan-meier method, along with the log-rank test, was employed for survival analysis. independent prognostic factors were identified through uni- and multivariable cox regression analyses.

Eligibility criteria:
inclusion criteria: * a confirmed diagnosis of gep-nens via histopathology with a who grading * available enhanced ct scans that included full abdominal imaging before surgery or biopsy exclusion criteria: * therapeutic interventions before surgery or biopsy * poor image quality or incomplete ct images of the whole abdomen
binge eating and chromium study

Conditions: Binge Eating Disorder

Summary: the purpose of this study is to test the feasibility and preliminary efficacy of a 6-month chromium picolinate (crpic) treatment trial in binge eating disorder (bed).

binge eating (i.e., the consumption of unusually large amounts of food with a sense of loss of control) is a common problem with serious public health implications in large part due to its role in obesity. binge eating leads to weight gain and is common in overweight individuals. current treatments for binge eating disorder (bed) are inadequate, and previous randomized treatment trials have suffered from high drop out rate due to the adverse effects of pharmacological agents. chromium picolinate is a dietary supplement that has been shown to reduce symptoms of depression and appetite regulation problems in patients with atypical depression; chromium picolinate also affects insulin regulation and has been shown to improve glucose levels in patients with type-2 diabetes. this pilot study will evaluate the effect of chromium picolinate on binge eating, mood, body weight, and glucose regulation in overweight individuals with bed.

Eligibility criteria:
inclusion criteria: 1. currently meets dsm-iv criteria for binge eating disorder (bed); 2. is able to provide informed consent and meet study visit requirements; and 3. is psychiatrically stable (e.g., no current suicidal or homicidal intent or other psychiatric condition that requires acute intervention). exclusion criteria: 1. body mass index (bmi) \< 24.9 kg/m\^2 (underweight or normal weight) or ≥ 40 kg/m\^2 (severely obese); 2. postmenopausal; 3. age \ 55 years; 4. pregnant, planning on becoming pregnant during the study period, or lactating; 5. current psychotropic medication use; 6. current use of insulin or other medications to control glucose metabolism; 7. current use of medications known to significantly influence appetite or weight \[i.e., over-the-counter appetite suppressants that contain phentermine or sibutramine, atypical antipsychotic agents with high weight gain liability (such as olanzapine, risperidone, etc), prednisone, etc.\]; 8. fasting glucose level \> 126 mg/dl (indicative of diabetes); and 9. creatinine level indicating renal insufficiency (\> 1.0 for women; \> 1.2 for men).

Keywords: binge eating chromium mood glucose appetite
mindfulness in preparation to bariatric surgery

Conditions: Obesity

Summary: mindfulness is a common practice already widely used, that has shown benefits in terms of psychological and physical health. it is about learning or learn again to be self present and aware to the environment, across breathing, sensations, emotions and thought centering exercises, in the present moment without any judgement. the goal is to evaluate the efficacy of "mindfulness" versus an active control group in bariatric surgery.


Eligibility criteria:
inclusion criteria: * adult patients: over 18 years * patients suffering from morbid obesity (bmi ≥ 40 kg/m²), or severe obesity (bmi ≥ 35 kg/m²) associate with at least a comorbidity likely to be improved by surgery * patient revised in second-line after the failure of a well conducted medical treatment, nutritional, dietetic and psychotherapeutic during 6 to 12 months : absence of enough weight loss or absence of maintain of weight loss * absence of any psychiatric counter-argument exclusion criteria: * subjects responding to inclusion criteria of the french national authority for health * subjects without agoraphobia, or obsessive-compulsive disorder, in post-traumatic stress disorder, alcohol or drugs dependant, without psychotic disorders, major depressive disorder, or suffering from anti-social personality disorder * patient registered for social security * free, signed and informed consent

Keywords: bariatric surgery mindfulness obese