Kornimate/medical-research-clean huggingface dataset:
new magnetic resonance imaging and spectroscopy software in the improvement of image quality

Conditions: Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm

Summary: this trial studies how well new magnetic resonance imaging (mri) and magnetic resonance spectroscopic imaging (mrsi) software works in improving the image quality of scans in both patients and healthy volunteers. improving the image quality of mri and mrsi through new software may lead to implementation of these techniques and better clinical care for patients.

primary objective: i. to help develop and/or optimize new magnetic resonance (mr) imaging and spectroscopy applications and analysis software in order to provide the best mr services for our patients. outline: patients undergo an additional investigational mri or mrsi sequence along with the standard mri or mrsi. healthy volunteers undergo an investigational mri or mrsi sequence. healthy volunteers may also undergo an additional standard sequence if there is one that can be compared to the investigational sequence. all mri or mrsi procedures, including the standard mri or mrsi, are no longer than 60 minutes.

Eligibility criteria:
inclusion criteria: * patients who are scheduled for routine mr imaging or spectroscopy examinations at md anderson cancer center (mdacc). * written informed consent will be obtained from each subject scanned who enrolled to individual sub-project under this protocol. * healthy volunteers: written informed consent will be obtained from each subject scanned who enrolled to individual sub-project under this protocol exclusion criteria: * no pregnant subjects will be enrolled * no one under 18 years of age will be enrolled * no investigational devices or drugs will be used. * no contraindications to mr exam(s) * healthy volunteers: no pregnant subjects will be enrolled * healthy volunteers: no one under 18 years of age will be enrolled * healthy volunteers: no investigational devices or drugs will be used * healthy volunteers: no contraindications to mr exam(s) - healthy volunteers will use the same screening process utilized for mdacc patients (di patient record - part i, mr screening section) * healthy volunteers: healthy volunteers (including healthy md anderson employee volunteers) under the direct report of a sub-project principal investigator (pi) will be excluded for that specific sub-project.
effects of hi-maize resistant starch on insulin sensitivity

Conditions: Insulin Resistance

Summary: the purpose of this study is to determine the effects of a dietary fiber, resistant starch, on insulin sensitivity. low insulin sensitivity is a risk factor for some diseases including type 2 diabetes and heart disease. this study will show if consuming resistant starch can help improve insulin sensitivity in overweight and obese people.


Eligibility criteria:
inclusion criteria: * stable body weight * no serious health conditions * waist circumference \> or = to 89 cm (females) and 102 cm (males) exclusion criteria: * diabetes * other serious illnesses * use of medications that affect outcomes * bmi \> or = 35.0 kg/m2

Keywords: insulin resistance dietary fiber resistant starch
measurement of mandibular radio morphometric indices in egyptian population at different ages

Conditions: Mandibular Fractures

Summary: this study aims to correlate mandibular indices and different ages in a sample of egyptian population.

this study is an observational cross sectional study to correlate the mandibular radiomorphometric indices with age in sample of egyptian population using cbct scans at faculty of dentistry cairo university

Eligibility criteria:
inclusion criteria: * egyptian individuals with different ages starting from 10 - 70 years. * females and males of the mentioned ages. exclusion criteria: * individuals younger than 10 and older than 70 years old. * presence of a large pathological lesions in the mandible at the areas intended for measurements. * patients of severely resorbed mandibular bone. * patients with any bony deformity at the inferior border of the mandible. * patients with fracture at the areas to be examined. * patients with evident radiographic asymmetry. * patients with evident radiographic abnormality suggestive of systemic disease predisposing to osteoporosis. * patients with current postoperative surgical defect healing at the areas intended for measurements. * patients with mandibular reconstruction
the influence of cessation of pomegranate juice intake on inflammation and oxidative stress markers and glucose control in diabetic and non diabetic chronic hemodialysis patients

Conditions: Inflammation; Oxidative Stress

Summary: the current study will investigate chronic hemodialysis patients who were treated in our unit with pomegranate juice intake for 1 year - compared to a control group. markers will be taken 3 months after cessation of pomegranate juice intake, for inflammation and oxidative stress and hb a1c.


Eligibility criteria:
inclusion criteria: * chronic hemodialysis patients three months after termination of study which is currently carried out at our unit; which compared patients taking pomegranate juice three times a week for 1 year to a group that received placebo juice. exclusion criteria: * patients who do not currently participate in above mentioned trial

Keywords: inflammation oxidative stress hba1c hemodialysis
assessment of sustained systolic-to-diastolic flexibility of the mitral valve annulus with the sorin memo 3d mitral anuloplasty ring

Conditions: Mitral Valve Disease

Summary: mitral valve reconstruction commonly requires the use of an anuloplasty device to assure long-term durability of the repair. among mitral anuloplasty devices, varying from rigid to complete flexible ring substitutes, the most recent ones are aimed to restore the natural saddle shape of the mitral annulus, in order to decrease the stress tension on both mitral leaflets and chordal attachments. so far, even for flexible ring devices, the sustained flexibility of the device remained unproven, probably by cicatricial fibrotic tissue ingrowth after implantation. due to specific structural characteristics based on a nitinolstent with carbofilm-coating, the memo 3d ring device of sorin claims preservation of the ring flexibility during the cardiac cyclus. consequently, mitral anuloplasty with this device is expected to decrease the stress during the systolo-diastolic movements of the valve, and so, improve the late durability of the repair. echocardiography is the first-line technique for mitral valve assessment after surgical repair, for both intra-operative evaluation and serial follow-up of valve function. recently, three-dimensional echocardiography has been introduced into clinical practice, affording qualitative and quantitative measurement of mitral valve function and size during the cardiac cycle.this method allows to quantify precisely the excursion of the mitral annulus between systole and diastole. the aim of this study is to analyse the systolo-diastolic movement of the mitral annulus after the use of an anuloplasty with the sorin memo 3d device, after surgical implantation and its sustainability, 1 year after implantation. this hypothesis is tested in a case-controlled comparison with a standard used rigid ring device. therefore, 3-d echocardiography will be performed at the time of surgical repair, and after 1 year, to define the size and surface change of the mitral anuloplasty device during the cardiac cycle. based on a sample size calculation, 10 patients in each comparison group will be included, suggesting a study cohort of 20 patients eligible for mitral valve repair.


Eligibility criteria:
inclusion criteria: * all patients requiring the use of an mitral anuloplasty device to restore the mitral competence by surgery are potential candidates for study inclusion, if survival of at least more than 1 year is expected

Keywords: mitral valve disease primarily regurgitation necessitating surgical repair
presentation, clinical course and patterns of myocardial damage due to viral myocarditis

Conditions: Viral Myocarditis

Summary: presentation, clinical course and patterns of myocardial damage due to viral myocarditis

1. determine the pattern of myocarditis in hospitalized patients with acute hf within the last 3 months. 2. determine the pattern of broad spectrum cardiotropic viruses in patients with acute hf within the last 3 months. these viruses like enteroviruses, adenoviruses and parvo b19 virus, hbv, hcv and covid 19 virus due to its increased prevelance nowadays.

Eligibility criteria:
inclusion criteria: all patients admitted with symptoms , signs and echocardiographic finding suggesting myocarditis within 3 months from start of the symptoms. as acute heart failure, arrhythmias, typical chest pain with st segment deviation in ecg . dilated cardiomyopathy associated with normal coronary angiography, history of upper respiratory tract infection within the last 3 months. exclusion criteria: 1. patients with significant coronary artery disease. 2. patient with family history suggesting familial dcmp 3. critically ill patients. 4. patients who refuse to do coronary angiography . . 5. patients with severe valvular heart disease. 6. pregnant women 7. patients with raised renal chemistry. 8. echocardiographic finding showing lvedd more than 6.5cm
fluency stent-graft versus luminex stent for angioplasty of recurrent stenosis of the cephalic arch in autogenous arteriovenous (av) access for hemodialysis

Conditions: Stenosis

Summary: the type of hemodialysis access and preservation of this access greatly influences the quality of life and survival of patients undergoing hemodialysis. the kidney disease outcomes quality initiative (k/doqi) guidelines for vascular access recommend the primary placement of native or autogenous hemodialysis fistulas in preference to polytetrafluoroethylene (ptfe) grafts and central venous catheters because the former form of access has fewer complications and a longer durability. however, autogenous hemodialysis fistulas, like polytetrafluoroethylene grafts, are also subject to dysfunction and eventual failure. endovascular angioplasty has become an accepted alternative treatment to surgical revision for hemodialysis access-related venous stenoses and occlusions. however, the patency rates in the follow-up period are low because of the high frequency of restenosis due to intimal hyperplasia. since 1988, noncovered stents have been used to improve fistula patency. in the central veins, bare stents demonstrate better patency rates than percutaneous transluminal angioplasty (pta) alone. neointimal hyperplasia is the major reason for restenosis following stent placement. the cephalic vein forms the outflow conduit for radiocephalic and brachiocephalic autogenous fistulas. it has recently been suggested that a focal area of the cephalic vein is prone to developing hemodynamically significant stenosis, in what is now termed the cephalic arch. this is the perpendicular portion of the cephalic vein in the region of the deltopectoral groove before its junction with the axillary vein. to overcome the problem of restenosis due to intimal hyperplasia in the cephalic arch the investigators used the insertion of a stent-graft as an alternative approach. in this study they investigated the use of a ptfe-covered nitinol stent-graft (fluency, bard) versus a luminex (bard) stent.


Eligibility criteria:
inclusion criteria: * patients included in this study would be presented for intervention after observation in the vascular access unit for one of the following: * the recurrent cephalic arch stenosis identified on periodic duplex scanning, performed by one of the surgeons from the vascular access unit; * reduction of flow rate of more than 20% from baseline access flow rate; * dynamic venous pressures exceeded threshold levels three consecutive times; or * clinical signs (arm swelling, pulsatile fistula, prolonged bleeding from puncture sites) suggesting fistula dysfunction in a patient with previously treated cephalic arch stenosis.
pubertal replacement in boys study nebido and testoviron depot treatment

Conditions: Puberty Delayed

Summary: in this prospective open clinical study, pubertal replacement in boys study (pribs), boys 14-16 years with delayed puberty in terms of slow pubertal progression, were randomized to soc treatment with te: testostoviron depot® 75 mg intramuscularly (i.m) / month (6 injections), or low dose tu: nebido® 250mg i.m. / 3 months (2 injections). our goal was to implement a study similar to clinical routine.

boys 14-16 years with pubertal delay were randomized to standard treatment with te (testosterone enanthat 75mg /month 6 injections)or newer treatment tu(testosterone undecanooat 250mg 2 injections 3 months apart) for pubertal induction. our study pribs (pubertal replacement in boys study) was academically sponsored, monitored and approved by the medical products agency in sweden. between 2014 -08 and 2019-07 27 boys were randomized to treatment with te (12 boys) or tu (15 boys). testosterone levels were measured twice before study start and after 2,7,30,60,90,180 and 365 days. boys with delayed puberty \> 14 years with morning testosterone levels 0,5 - 3 nmol/l and testicular volume ≤ 6 ml were included.primary outcome was testicular enlargement ≥ 8ml after 12 months. the new treatment was considered clinically similar if the treatment result were in the 80-125% interwall of the traditional group. fishers exact chi square test was used for this analysis. our intention was to recruit 20 boys in each arminformed consent was signed before study start by parents and assent by the boys. pribs was approved by the regional ethic committee 2012-09-14 dnr 506-12 and approved by union drug regulating authorities clinical trials database eudract nr 2012-002337-11 and the swedish drug authorities (läkemedelsverket) all study personal was trained in ich gcp (good clinical practice).

Eligibility criteria:
inclusion criteria: * • signed informed consent * two morning testosterone values (07.30-09.00) of 1-3 nmol/l and at start \< 4 mmol/l ¹ * testicular volume 4-6 ml bilaterally² exclusion criteria: * • growth spurt * untreated hypothyroidism, celiac disease or steroid medication * training doses \> 10 hours a week * use of anabolic steroids or other drugs
hybrid operating treatment of coexistence of intracranial aneurysms and cerebrovascular stenosis

Conditions: Intracranial Aneurysm; Cerebrovascular Stenosis; Atheroscleroses, Cerebral

Summary: to evaluate the clinical benefits and risks of hybrid operating techniques in management of intracranial aneurysms with coexistence of atherosclerotic intracranial arterial stenosis.

purpose: have an evaluation of clinical benefits and risks of hybrid operating techniques in management of intracranial aneurysms (ias) with coexistence of atherosclerotic intracranial arterial stenosis (aias), whose management strategies are inconsistent. meanwhile, as a new cooperative interventional modality, optimized workflows, technical key knots and operation routines will be explored in the study. objects: patients with ias with coexistence of aias, coincident with inclusion and exclusion criterion and admitted in participating organizations. methods: patients will be distributed into 2 groups, including traditional therapy group(control group) and hybrid operating group(trial group), and conduct with traditional multi-stage neurosurgical management or one-stage hybrid operating management correspondingly. the morbidity rate of peri-operative cerebral hemorrhagic/ischemic event is considered to be the primary observing indicator, and morbidity rate of peri-operative cerebral hemorrhagic/ischemic event, while peri-operative mortality rate, and health-economic indicators are secondary indicators.the information of operations will be recorded in detail as evidence of optimization of workflow and technical key knots.

Eligibility criteria:
inclusion criteria: * for aneurysms: * with diagnosed complex intracranial aneurysm by digital subtraction angiography(dsa); * got sah in history; * neural functional deficits due to aneurysms; * with \<4 in hunt-hess grades; * ≥5.0mm in the maximum diameter; * \<70 years old; * with irregular morphological features and high rupture risk. and for stenosis * intracranial vessels: * \>50% in rate of stenosis with ischemic symptoms/perfusing evidence/lacunar infarction in supplying territory, failed in conservative treatment; * with a deliverable position of intracranial stents devices. * or vertebral arterial system: * ≥70% in the rate of stenosis, with contralateral vertebral arterial occlusion; * symptomatic vertebral arterial stenosis, accompanied with posterior inferior cerebellum artery derived from the affected artery and related symptoms are caused/clinical benefits can be achieved through angioplasty. * or extracranial arterial system: * ≥70% in the rate of stenosis with symptoms; * nonsymptomatic patients, ≥70% in the rate of stenosis , with perfusing evidence. exclusion criteria: * \>70 in age, with low rupture risk; * stroke history in 6 weeks (contraindication for endovascular intervention); * coexistence with intracranial tumor or avm; * cannot tolerant the operation; * patient or relative refuses to participate the trail
evaluation of advanced glycation end-products (age) and the erectile dysfunction (de) in diabetic patients

Conditions: Diabetes Mellitus, Non-Insulin-Dependent; Erectile Dysfunction

Summary: in diabetics there is an abnormally increased production of ages due to hyperglycemia. an association was shown between age measured by biopsy (invasive) and de patients with diabetes (increase of age level in the corpora cavernosa). to date no studies have explored the link between de and the measure of age by a non-invasive method of auto-fluorescence (af) skin (agereadertm). if the hypothesis of an association between de and age measured by af was checked, screening for erectile dysfunction and measurement of ages could help to improve the overall management of diabetic patient (including cardiovascular) and their quality of life.


Eligibility criteria:
inclusion criteria: * diabetes type 2 exclusion criteria: * skin hyperpigmentation
the effect of aerobic exercise in patients with lacunar stroke

Conditions: Stroke, Lacunar

Summary: in a randomized-controlled study the effect of high-intensity training, 5 days a week at home for 12 weeks is tested in patients with lacunar stroke.

little is known about effect of exercise for patients with lacunar stroke, no studies have investigated the feasibility or effect of aerobic exercise in this subgroup of stroke. the patients have few and temporary symptoms and are therefore early discharged from the hospital. after an cerebral infarct the patients have increased risk of recurrent stroke and they are at risk of developing cognitive deficits or vascular dementia over time. researchers want to investigate if high-intensity training at home in the acute phase has an effect on aerobic fitness, endothelial response and health profile in this potential fragile group of patients. we hope to increase the patients´ physical and mental function, and thereby prevent a recurrent stroke and slow the progression of vascular diseases.

Eligibility criteria:
inclusion criteria: * lacunar stroke verified by clinical examination and ct- or mri-scans * able to speak and read danish exclusion criteria: * previous large artery stroke, * symptoms or co-morbidities in the musculoskeletal system, which hinder bicycling, * dyspnoea caused by heart or pulmonary disease, * aphasia or dementia which hinder completion of the talk test. amendment 1 (version 4.0, june 2016) has been modified to allow an extended inclusion period from 0-21 days (previously 0-7 days). also, to allow inclusion of patients with recurrent lacunar stroke, with clinical symptoms and a corresponding ischemic lesion on mri. amendment 2 (version 5.0, june 2017) has allowed inclusion from two other stroke units in the capital region of copenhagen due to low recruitment rate. the article describes protocol version 5.0 from june 6th. 2017

Keywords: stroke stroke, acute cerebral small vessel disease
association among pain perception, severity of temporomandibular joint dysfunction, and spinal health in caregivers of stroke individuals

Conditions: Pain; Discomfort; Caregiver; Temporomandibular Disorder; Spine

Summary: this study aims to examine pain perception, temporomandibular disorder severity and spine health in caregivers of stroke patients.

the sample of the study will consist of caregivers who reside in tokat and kırıkkale, are over 18 years old, care for an individual who has had a stroke and volunteer to participate in the study. individuals will be contacted via social media, and squestionnaires will be administered face-to-face to those who agree to participate in the study. according to the g\*power analysis, if the sample size is α= 0.05, β= 0.80, acceptable correlation coefficient r= 0.70, and negligible correlation coefficient r= 0.20, 16 individuals are sufficient to measure the relationship between two parameters. since the relationship between four parameters will be evaluated, a total of 64 individuals are required. data for the study will be collected face-to-face by individual researchers using data tools that individuals can fill in themselves. data will be collected from individuals with the centrality of pain scale, discomfort intolerance scale, spine functional index, and fonseca anamnestic index instruments. statistical package for social sciences (spss), version 22.0 computer package program for windows, will be used for statistical analysis. statistical data will be expressed as mean ± standard deviation (x±sd), median or percentage (%). one sample kolmogorov smirnov test will be performed to show parametric or nonparametric distribution of the data. when parametric test assumptions are met, the relationship between parameters is determined by spearman correlation test; when parametric test assumptions are not met, the relationship between the parameters will be examined with the pearson correlation test. statistical significance value will be accepted as p\<0.05.

Eligibility criteria:
inclusion criteria: * to be volunteer exclusion criteria: * those who cannot speak, read or write turkish.

Keywords: caregiver pain discomfort spine temporomandibular disorder
effectiveness of a rehabilitation program in improving quality of life in patients with esophageal cancer

Conditions: Esophageal Cancer

Summary: this study will investigate the effectiveness of a rehabilitation program in improving sleep quality, emotional distress, circadian rhythms, and quality of life in patients with esophageal cancer in taiwan. hypothesis: 1. the quality of life in exercise group is significant improving than usual-care group at 3rd, 6th, 12th, 24th, and 36th month. 2. the quality of sleep in exercise group is significant improving than usual-care group at 3rd, 6th, 12th, 24th, and 36th month. 3. the emotional distress in exercise group is significant improving than usual-care group at 3rd, 6th, 12th, 24th, and 36th month. 4. the circadian rhythms in exercise group is significant improving than usual-care group at 3rd, 6th, 12th, 24th, and 36th month.

this study will investigate the effectiveness of a rehabilitation program in improving sleep quality, emotional distress, circadian rhythms, and quality of life in patients with esophageal cancer in taiwan.

Eligibility criteria:
inclusion criteria: * patients with esophageal cancer who were aged ≥20 years, could communicate in either mandarin or taiwanese, and were not cognitively impaired were included. exclusion criteria: -