Kornimate/medical-research-clean huggingface dataset:
comparing the effect of deep neck flexors versus mckenice exercises on cervical functions

Conditions: Chronic Neck Pain

Summary: physical therapy rehabilitation programs could involve manual procedures, stretching, traction, massage, electrotherapy, thermal agents, ultrasound, education and general exercise..in the recovery of patients with neck pain, exercise is one of the most commonly used modalities to gain muscle strength, endurance, and flexibility in order to recover damaged muscles and to maintain regular life activities.. neck pain management exercise programs vary in terms of length, training frequency, intensity, and mode of exercise. .

this study will be a randomized controlled trial that involved sixty patients of both gender with chronic neck pain with duration of at least six weeks that will be recruited into the study. they will be recruited from the out patient clinic of faculty of physical therapy, egypt ,their age ranged from (30-50) years old with mean age, their height ranged from (152-182) cm and their weight ranged from (55-90) kg , patients will be included if they had a localized chronic neck pain without any current arm pain or discomfort were included.groups: a: twenty patients will receive traditional physical therapy agents, group b: twenty patients will receive traditional physical therapy agents plus isometric, stretching, scapulothoracic exercises and deep neck flexors exercises; and group c: twenty patients will receive traditional physical therapy agents plus isometric, stretching, scapulothoracic exercises and mckenzie technique.

Eligibility criteria:
inclusion criteria: 1. age ranges from (30-50) years old with mean age, 2. height ranges from (152-182) cm and their weight ranged from (55-90) kg 3. patients will be included if they have a localized chronic neck pain without any current arm pain or discomfort were included. exclusion criteria: 1. history of cervical spine injury or surgery, if neck pain is secondary to other conditions (including neoplasm, neurological diseases or vascular diseases), 2. they have a radiculopathy presenting neurological deficit 3. they had infection or inflammatory arthritis in the cervical spine, 4. they have pain with any cause in or around the scapula, shoulder, upper extremities and lumbar spine that prevents stabilization of these structures.

Keywords: mc kenzie chronic neck pain deep neck flexor
efficacy and safety of qizhitongluo capsule in the recovery phase of ischemic stroke

Conditions: Ischemic Stroke

Summary: this is a 20-week study consisting of a 12-week multicenter, randomized,double-blind adaptive study to compare efficacy and safety of qizhitongluo capsule,naoxintong capsule and placebo in the recovery phase of ischemic stroke with qi deficiency and blood stasis syndrome, and a 8-week post-treatment safety follow-up.after 312 patients complete 12 weeks of treatment there will be an interim analysis.


Eligibility criteria:
inclusion criteria: * age≥35 years and \<80 years; * diagnosis of ischemic stroke in recovery phase, according to the chinese guidelines for the diagnosis and treatment of acute ischemic stroke 2010; * diagnosis of ischemic stroke with qi deficiency and blood stasis syndrome; * the interval from the onset to recruitment was 15-28 days; * fm score \<90 or aq\<93.8 and diagnosis of aphasia; * diagnosis of cerebral anterior circulation obstruction; * 4≤ nihss score\<20; * patient is willing to participate voluntarily and to sign a written patient informed consent. exclusion criteria: * evidence of intracranial hemorrhage (ich) or other cerebral diseases (eg.vascular malformation, tumor, abscess or multiple sclerosis etc.) on ct or mri. * known history of allergy or suspected allergic to the study drugs. * liver function impairment with the value of alt or ast over 1.5-fold of normal value. * renal dysfunction with the value of serum creatinine over 1.5-fold of normal value. * cerebral embolism caused by cerebral tumor, cerebral trauma, cerebral parasitosis, rheumatic heart disease, coronary heart disease or other cardiac diseases complicated with atrial fibrillation. * prestroke score on the mrs ≥2. * space-occupying lesions, ct or mri revealed midline structure shift; ct revealed that massive cerebral infarction including more than one lobe of brain or over 1/3 of blood-supply area of middle cerebral artery. * disable patients prescribed by law（blind, deaf, dumb, mental retardation, mental disorders and physical disabilities which due to other causes affect neural function deficient scale). * hemorrhagic tendency or recent severe or dangerous bleeding in 3 months. * suspected addicted into alcohol or drug abuse; with severe complications that would make the condition more complicated assessed by the investigator. * woman with pregnancy, lactation or positive result of pregnancy test, or women who want to be pregnant in recent. * patient who is participating in other trials or has been participated in other trials in recent 3 months.

Keywords: ischemic stroke,adaptive design, randomized, double-blind
does pre-operative patients' education facilitates emergence of anesthesia following bariatric surgery?

Conditions: Obesity

Summary: the recovery and emergences from anesthesia is a critical phase. previous studies focused on pharmological and anesthetics techniques to improve the quality of this stage (duration, complications). in this study, our first aim is to test the impact of pre operative education on the post operative recovery for morbidly obese patient underwent laparoscopic bariatric surgery.

the purpose of our study is to compare post operative immediate recovery and emergence for educated and non educated morbidly obese patients underwent laparoscopic bariatric surgery. elligibles patients are informed and consented by anesthesiologist. patients are randomized in 2 groups (g1: educated, g2:non-educated) patient of g1 are educated in or before starting anesthesia. this education includes : information about anesthesia emergence, recovery and extubation. anesthesia and education are conducted by the same anesthesiologist. all patients are operated by the same surgeon. all patients receive same balanced general anesthesia protocol. the recovery starts immediately after the end of the procedure, when the patient has bis ≥90 and tof≥9. recovery assessment and data recording is done by a blinded anesthesiologist.

Eligibility criteria:
inclusion criteria: * adults more than 18 years old. * asa 2. * bmi more than 35. * scheduled for laparoscopic sleeve gastrectomy or gastric bypass surgery. exclusion criteria: * renal impairment. * hepatic dysfunction. * alcohol or drug abuse. * disabling central nervous or cerebrovascular diseases. * treatment with opioids or any psychoactive medication. * inappropriate mini mental state exam.
the relationship between breastfeeding during early pregnancy and miscarriage

Conditions: Miscarriage; Breast Feeding

Summary: breastfeeding provides various health and psychological benefits to mothers and their babies. it also acts as an effective method of natural contraception when applied strictly for up to six months after birth. studies show that breastfeeding times are getting longer in the usa and more babies are breastfed for more than 12 months compared to the past. recent research shows that 57% of us infants are breastfed until at least six months of age, and more than a third continue to be breastfed for up to 12 months. prolonged breastfeeding durations increase the prevalence of breastfeeding during pregnancy, especially with the shortening of the intervals between pregnancies. breastfeeding during pregnancy is a relatively common practice in many parts of the world. according to the data of studies conducted in low- and middle-income countries, it has been determined that 35% of the last born babies continue to be breastfed in the next pregnancy of their mothers. it has also been shown that the prevalence of breastfeeding during pregnancy in low-income countries is between 15% and 50%. few research has been done on the relationship between breastfeeding during pregnancy and maternal, infant, or pregnancy outcomes. some studies have suggested that hormonal mechanisms in pregnancy may link breastfeeding during pregnancy and abortion. when babies stimulate the nipple and areola during sucking, they trigger the release of oxytocin in the mother, causing a series of reactions that push the milk towards the nipple. we know that the prevalence of short and long breastfeeding intervals in pregnancy is high in our country. therefore, in this study, we are planning to investigate whether there is a relationship between breastfeeding during pregnancy and miscarriage based on this information.

our aim in this study is to investigate whether breastfeeding during pregnancy increases the risk of abortion and to determine whether there is a relationship between them. for this purpose, approximately 76 pregnant women who were pregnant and continuing to breastfeed in siirt training and research hospital between june 2022 and december 2022 will be included in the study. the same number (n:76) non-breastfeeding pregnant control group will be included in the study. age, gestational week, pregnancy history (gravida, parity, abortion, missed, ectopic),breastfeeding time in previous pregnancies, bleeding, daily breastfeeding frequency and medical history of the pregnant will be recorded. in the light of the information obtained in this way, we plan to determine whether there is a relationship between breastfeeding during pregnancy and abortion.

Eligibility criteria:
inclusion criteria: * being breastfeeding * being at the 1.st trimester of pregnancy exclusion criteria: * history of inherited thrombophilia * history of uterine anomaly * history of trauma * history of genetic anomaly * history of habitual abortus
cognitive behavior therapy for insomnia delivered by a therapist or on the internet

Conditions: Insomnia

Summary: background: insomnia is a highly prevalent and disabling disorder where cognitive behavior therapy for insomnia (cbt-i) is established as the best available treatment. still, only a negligible number of patients with insomnia receive this treatment. one potential way of improving the dissemination of cbt-i is by using online adaptations of cbt-i. this is a new method for delivering cbt-i and it is not known how effective online treatment is compared to face-to-face cbt-i. this trial's purpose is to compare face-to-face cbt-i with online cbt-i. because of the great advantage of online treatment in both availability and cost, the trial is designed as a noninferiority trial. aim: to test if online cbt-i is noninferior in reducing insomnia complaints compared with cbt-i as delivered face-to-face by a therapist.


Eligibility criteria:
inclusion criteria: * meeting the diagnostic and statistical manual of mental disorders (dsm)-5 diagnostic criteria for insomnia disorder exclusion criteria: * a condition that renders the patient incapable of understanding the treatment (e.g. actively psychotic, mental retardation, dementia or others * an ongoing substance abuse problem * other organic sleep disturbances or circadian sleep disturbance * an ongoing medical condition where treatment of insomnia is not indicated (e.g. an attack phase of multiple sclerosis) * working night shifts and being unable to discontinue this work pattern * not being sufficiently fluent in norwegian to understand the assessments or treatment * not having the necessary computer skills needed to log on to the web based program

Keywords: cognitive therapy behavior therapy waiting lists therapy, computer-assisted internet
diagnostic strategies in patients suspected of irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: the purpose of this study is to determine whether a clinical diagnosis of irritable bowel syndrome based on patient reported symptoms and a few blood tests is safe, and to determine whether a clinical diagnosis is as good for the patient and as economical for the society as a diagnosis based on exclusion of a number of organic diseases by performing a number of blood tests, fecal analyzes and a scopic examination of bowel. the purpose of the second part of the study is to determine which intestinal parasites the patients have in their bowel and whether these parasites are the cause of the disease.


Eligibility criteria:
inclusion criteria: * age 18-50 years * consultant in general practice for gastrointestinal symptoms, where the gp suspects irritable bowel syndrome * full fill the rome iii criteria * signed informed consent exclusion criteria: * alarm signals * pregnancy * comorbid diseases, that interfere with primary endpoint * medicine and alcohol abuse * patient do not speak or understand danish * investigations for irritable bowel syndrome with in the last 3 years from november 2008: patients aged above 40 with a duration shorter than one year

Keywords: ibs diagnosis
the long term effect of inhaled hypertonic saline (6%) in patients with non cystic fibrosis bronchiectasis

Conditions: Bronchiectasis

Summary: the purpose of this study is to determine whether the daily inhalation of nebulised hypertonic saline (6%) will decrease the incidence of pulmonary exacerbations and increase the quality of life for people with non cystic fibrosis bronchiectasis.

bronchiectasis is a disabling, chronic respiratory condition which significantly impacts on the quality of life of patients who present with chronic sputum production and respiratory infections. the occurrence of pulmonary infections is a strong predictor of morbidity and mortality in this group of people so the primary goal of treatment is to prevent infections caused by the presence of sputum in their lungs. physiotherapy is a major aspect of their management and focuses on teaching appropriate airways clearance techniques. traditionally, the physiotherapy management of sputum retention due to bronchiectasis has included the active cycle of breathing technique which has been demonstrated to enhance airways clearance. for some patients, this treatment is not adequate. the use of nebulised hypertonic saline has been used for patients with cystic fibrosis and has been demonstrated to improve sputum removal and lung function. the aim of this project is to determine the long term effect of the daily inhalation of hypertonic saline on respiratory infections, quality of life, lung function and hospital admissions in patients with non cystic fibrosis bronchiectasis. hypertonic saline has been shown to be beneficial as a once only treatment in this patient group, but its' long term effects have not been studied. participants will be randomised to two groups - those receiving hypertonic saline (6%) and those receiving isotonic saline (0.9%) - and will be blinded to the treatment that they are receiving. they will be given nebuliser equipment and will be instructed how and when to inhale their medication. objective measures will be taken by a blinded assessor before the commencement of the project and then at 3 months, 6 months and 12 months post commencement.

Eligibility criteria:
inclusion criteria: * diagnosis of bronchiectasis on high resolution computer tomography * at least 2 respiratory exacerbations per year over the past 2 years * producing sputum daily * in a stable clinical state * over 18 years of age. exclusion criteria: * cystic fibrosis * positive response to hypertonic saline challenge - fev 1 decreased by ≥ 15% * fev 1 ≤ 1l
comparison study of the icon™ auto series with and without sensawake™ and thermosmart™ and conventional continuous positive airway pressure in obstructive sleep apnea patients

Conditions: Sleep Apnea, Obstructive

Summary: a total of 216 patients will be randomized into a partially single blind, randomized, parallel-arm trial to determine whether the icon™ at with sensawake™ and thermosmart™ can improve therapy adherence when compared to standard care with a fixed pressure continuous positive airway pressure (cpap) device and compared to a less aesthetically pleasing cpap device without technologies (autocpap, sensawake™, thermosmart™) in patients previously diagnosed with moderate-severe obstructive sleep apnea (osa).


Eligibility criteria:
inclusion criteria: * aged 18-70 years with moderate-to-severe osa (apnea hypopnea index equal to or greater than 10 per hour). * successful titration polysomnography (psg). * fluency in both written and spoken english. exclusion criteria: * participants prescribed and fitted with any pap device in the past 2 years. * contraindicated for cpap or autocpap therapy. * any known factor or disease that might interfere with treatment adherence, study conduct or interpretation of the results such as severe psychiatric disease, history of non adherence to medical regimens, or unwillingness to comply with study requirements as determined by the principal investigator. * other significant sleep disorder(s) that would interfere with their ability to wear cpap as determined by the principal investigator. * previous surgery for osa or snoring or any surgery of the mouth, nose, sinuses or airways. * if sensawake™ or thermosmart™ was disabled on the treatment arm (or conversely) during the study protocol. * if participants are required, by the nature of their employment, to comply with therapy. for example truck drivers or airline pilots. * if the physician objects to their patient taking part in the study.

Keywords: obstructive sleep apnea humidification continuous positive airway pressure icon thermosmart sensawake
boston outcomes of autism in toddlers study

Conditions: Autism Spectrum Disorder; Autism

Summary: the purpose of this research study is to learn more about the outcomes of children who received an autism spectrum disorder (asd) diagnosis when they were toddlers. the study is interested in whether an early diagnosis can help children with their cognitive, language, social, and behavioral abilities.

autism spectrum disorder (asd) is a neurodevelopmental disorder characterized by deficits in domains of social communication and restrictive and repetitive behavior. there is general agreement, in light of knowledge around optimal periods of neural plasticity, that asd should be diagnosed as early as possible since young toddlers are at a critical stage in early development when intervention is theoretically most effective. the rate of persistence of an asd diagnosis is heavily debated.therefore this study attempts: 1. to determine the rate of persistence of autism spectrum disorder (asd) diagnosis and functional outcomes, as defined by cognitive level, adaptive functioning, language skills, persistence of asd symptoms, and classroom placement at kindergarten age, among children who received a dsm-5 asd diagnosis at \< 36 months. 2. to evaluate predictors of rate of persistence and functional outcomes among kindergarten grade level children ages 5-7 years, who received an asd diagnosis as toddlers.

Eligibility criteria:
inclusion criteria: * diagnosed with autism spectrum disorder as a toddler through dsm-5 at boston children's hospital * enrolled in or just finished kindergarten exclusion criteria: * individuals with known genetic disorders including, but not limited to, fragile x syndrome, down syndrome, tuberous sclerosis complex and those with 16 p deletions/duplications.

Keywords: asperger's autism autism spectrum disorder asd
fapi in rectal cancer tnt

Conditions: Rectal Neoplasms Malignant

Summary: the goal of the trial is to observe the changes of 68ga fapi signal before and after total neoadjuvant therapy for rectal cancers, and the correlation between the image parameters, immune checkpoints expression as well as the patient outcome. the trial will recruit patients with biopsy-confirmed rectal cancer aged 18 years old or older, with who/ecog performance status 0-1, and eligible for total neoadjuvant therapy at the clinicians' discretion. after signing the informed consent, the participants will undergo a standard staging work-up if not already done, including colonoscopy and cross-sectional images such as ct, mr, and fdg-pet. kidney function (by serum creatinine) and liver function (by serum alanine aminotransferase) will also be assessed. only patients with stage ii-iii rectal cancer will be recruited. if patients meet the inclusion and exclusion criteria, they will undergo the first 68ga-fapi pet within 30 days before the beginning of total neoadjuvant therapy. at 22-24 weeks into the tnt, follow-ups for response evaluation will be conducted, including colonoscopy and cross-sectional images such as ct, mr, and fdg-pet. the second 68ga-fapi pet will be performed within one month of these exams. afterward, participants will either undergo surgery or have image follow-ups every 3 months. the participants will be followed up for up to 2 years after the second 68ga-fapi pet, and immunochemical staining with cd47, cd73, pd-l1, and fap on the biopsy or surgical specimens will be performed in one batch to avoid batch-to-batch variation.


Eligibility criteria:
inclusion criteria: 1. biopsy proven newly detected adenocarcinoma of the rectum 2. clinical stage ii-iii rectal cancer 3. aged at least 18 years. no upper age limit. 4. who/ecog performance status 0-1 5. eligible for total neoadjuvant therapy exclusion criteria: 1. distant metastases found on either ct, mr or fdg-pet 2. prior anticancer therapy for colorectal cancer 3. prior radiotherapy of the pelvic region 4. other concurrent antineoplastic therapy 5. major surgery within the last 4 weeks prior to inclusion 6. subjects pregnant or breast feeding 7. serious concurrent diseases not compatible with study entry, including active, uncontrolled infections, active, disseminated coagulation disorder, clinically significant cardiovascular disease (including myocardial infarction, unstable angina, symptomatic congestive heart failure, serious uncontrolled cardiac arrhythmia within 6 months before enrolment) 8. neurologic or psychiatric disorders including dementia, uncontrolled seizures, substance abuses, severe depression 9. prior or concurrent malignancy within 3 years prior to enrolment (except non-melanoma skin cancer or cervical carcinoma figo stage 0-1) 10. allergic to contrast agents or to the main ingredients or excipients of the experimental radiopharmaceutical 68ga fapi, including acetate, ascorbic acid and normal saline 11. those deemed unsuitable for participation in the trial by the investigators.