Kornimate/medical-research-clean huggingface dataset:
single session consultation for parents

Conditions: Parents; Stress

Summary: single-session consultation (ssc) is a rapidly provided, low-intensity, goal-directed counseling service used for treatment of diverse mental health problems. research on ssc suggests that, for some clients, a single session of counseling (60 minutes) may help reduce clinical distress. despite its benefits, ssc has yet to be evaluated as an alternative for parents (18+) of school-age children (5-12 years old) in the united states with elevated stress levels. the current research aims to evaluate ssc's feasibility, acceptability, and efficacy as an intervention for this population. first, perceived acceptability (i.e., parents' participation and successful completion, reschedules, and/or cancellations), usefulness, and client satisfaction will be examined. the investigators will also evaluate whether mechanisms of change (e.g, hope, agency), parental (e.g, stress, mental health), and child (e.g, behavior) outcomes, are improved following the ssc. the investigators expect ssc to be acceptable, for clients to find ssc to be useful, to be satisfied, and experience an increase in hope and agency after the ssc and hypothesize a reduction in stress levels and improvement in mental health among parents. however, the investigators believe behavior outcomes for the child will remain unchanged. the investigators will recruit parents via online advertisement on social media. potential participants will complete a screener through qualtrics to determine eligibility, which includes location in the united states, age (18+), child's age (5-12 years old), preferred language, child's legal guardianship, technology access, and stress levels. once eligible, participants will provide consent and make an appointment for their ssc. the 60-minutes-session will be conducted using hipaa complaint nyu zoom with study consultants. parents will complete assessments of parental stress, parental mental health, and child behavior to assess mechanisms (i.e., hope, agency) outcomes and measures of usefulness and satisfaction prior and post the ssc, and another 2-week follow-up questionnaire to monitor progress. sessions will be recorded for supervision and treatment fidelity purposes. upon completion, parents will receive an action plan, a written record of the discussion, recommendations, and resources.


Eligibility criteria:
inclusion criteria: 1. adult parents (18+ years old) who are legal guardians of their school-age children (5 to 12 years old) 2. must have elevated stress levels based on validated measures obtained through parent self-report 3. parent must reside in the united states 4. must be english dominant 5. can access video-based zoom conference exclusion criteria: 1. parent has significant cognitive delays that prohibit involvement in ssc 2. parent expresses significant personal mental health challenges/child abuse during ssc that warrant immediate discontinuation from ssc.

Keywords: single session consultation ssc parents parental stress parenting stress stress disorders children school-aged children parental mental health
svangerskap, arv, og miljo (pregnancy, heredity and environment)

Conditions: Birth Defects; Cleft Palate; Cleft Lip

Summary: this proposal describes a population-based case-control study of all norwegian infants born with cleft lip or palate over a five-year period. the study will be jointly supported by the u.s. national institute of environmental health sciences (niehs), and the norwegian national institute of public health (siff) and medical birth registry of norway (mbr). cases will be identified through the two surgery clinics that treat all clefts in norway. controls will be randomly selected from all live births through the mbr. mothers will complete two selfadministered questionnaires; one regarding exposures before and during pregnancy, the other their diet during their early months of pregnancy. biological specimens for dna testing (blood samples, buccal swabs) will be collected from cases, controls and mothers in order to describe possible gene-environment interactions. with 750 cases and 1100 controls, this will be one of the largest and most complete field studies of facial clefting yet conducted.

this proposal describes a population-based case-control study of all norwegian infants born with cleft lip or palate over a five-year period. the study will be jointly supported by the u.s. national institute of environmental health sciences (niehs), and the norwegian national institute of public health (siff) and medical birth registry of norway (mbr). cases will be identified through the two surgery clinics that treat all clefts in norway. controls will be randomly selected from all live births through the mbr. mothers will complete two selfadministered questionnaires; one regarding exposures before and during pregnancy, the other their diet during their early months of pregnancy. biological specimens for dna testing (blood samples, buccal swabs) will be collected from cases, controls and mothers in order to describe possible gene-environment interactions. with 750 cases and 1100 controls, this will be one of the largest and most complete field studies of facial clefting yet conducted.

Eligibility criteria:
* inclusion criteria: we expect to enroll about 150 infants with cleft lip or palate annually for five years (550 with cleft lip with or without cleft palate, and 200 with cleft palate alone) controls will be chosen randomly from all norwegian live-births through the medical birth registry. exclusion criteria: there will be no exclusion by race, sex or ethnic group.

Keywords: birth defects cleft lip and palate genetic susceptibility
the clopidogrel and aspirin after surgery for coronary artery disease

Conditions: Atherosclerosis

Summary: clopidogrel is a antiplatelet agent and is effective at reducing intimal hyperplasia in animal models of thrombosis.several large clinical trials have demonstrated that clopidogrel with aspirin can reduce ischemic events and mortality in patients with atherosclerotic disease,therefore the combination of two antiplatelets might be useful to prevent patients received coronary artery bypass graft surgery from saphenous vein graft disease. the aim of this study is to estimate the safety and efficacy of clopidogrel and aspirin therapy versus aspirin alone in patients after cabg.


Eligibility criteria:
inclusion criteria: * patients undergoing primary multi-vessel cabg with at least two saphenous vein grafts, with or without the use of cardiopulmonary bypass. exclusion criteria: * emergency surgery * valve surgery * redo cabg * left ventricle ejection fraction \< 30% * preoperative use of clopidogrel (with the exception of the current admission) * preoperative use of warfarin * allergy to aspirin or clopidogrel * history of cerebrovascular accident * history of severe liver disease * morbid obesity * current malignancy
quality of life and supportive care preferences following radiation therapy in prostate cancer survivors

Conditions: Prostate Carcinoma

Summary: this pilot clinical trial studies quality of life and supportive care preferences following radiation therapy in prostate cancer survivors. studying quality of life and supportive care preferences in patients undergoing radiation therapy may help identify the effects of treatment on patients with prostate cancer.

primary objectives: i. to develop an understanding of the impacts of prostate cancer on aspects of psychological stress, physiological stress and health related quality of life (hrql) for men who are being treated with some level of radiation therapy (rt). ii. to gain insight into the perceived needs of survivors depending on their disease stage, treatment regimen and side effects. secondary objectives: i. to explore whether biomarkers of stress, inflammation and autonomic control (heart rate variability \[hrv\]) can confirm or dispel the self-reported measures of psychological distress and hrql of a unique population of aging men with prostate cancer. outline: participants complete questionnaires about quality of life and preferences for supportive care treatment, undergo heart rate variability testing over 10-15 minutes while both lying down and standing, complete a walking test, wear an accelerometer for a period of 1 week, and undergo a single intelligent dual-energy x-ray absorptiometry (idxa) scan over 10 minutes.

Eligibility criteria:
inclusion criteria: * english speaking * diagnosis of prostate cancer * treatment with primary radiation (brachytherapy or external beam therapy), radiation + androgen deprivation therapy (adt) or salvage prostatectomy * body mass index (bmi) (26 - 40 kg/m\^2) * treating oncologist consent * ambulatory or able to engage in walking for at least 45 minutes per intervention visit * sedentary lifestyle, as engaging in less than 100 minutes structured aerobic walking, cycling or swimming per week exclusion criteria: * poor diagnosis or other cancer * severe heart or systemic disease: evidence of documented myocardial infarction, chronic unstable angina, symptomatic congestive heart failure, uncontrolled hypertension * severe musculoskeletal disease: severe muscle or joint disorders due to disease or trauma, amputations, or any condition that significantly impair physical capabilities, as defined by the physician * non-ambulatory * concurrent diagnosis of organic brain syndrome, dementia, mental retardation, or significant sensory deficit * major mental illness (e.g., schizophrenia, major depressive disorder) * unwilling to give consent

Keywords: prostate cancer survivor
monitoring patients for developing communicable and opportunistic infections and for responding to therapy

Conditions: Communicable Diseases; Opportunistic Infections

Summary: patients are exposed to infectious agents regularly, regardless of their immunologic status. traditionally clinicians have decided to institute prophylaxis based on epidemiologic factors, skin test (i.e. ppd), or immunologic parameters. a quantitative and specific method that is non-invasive, such as quantitative pcr, would be desirable to more precisely define those who would benefit from prophylaxis. similarly, when patients develop disease and are being treated, quantitative, non-invasive techniques are needed to assess response to therapy. this project is designed to develop and test quantitative tests using blood, urine, or sputum samples.

patients are exposed to infectious agents regularly, regardless of their immunologic status. traditionally clinicians have decided to institute prophylaxis based on epidemiologic factors, skin test (i.e. ppd), or immunologic parameters. a quantitative and specific method that is non-invasive, such as quantitative pcr, would be desirable to more precisely define those who would benefit from prophylaxis. similarly, when patients develop disease and are being treated, quantitative, non-invasive techniques are needed to assess response to therapy. this project is designed to develop and test quantitative tests using blood, urine, or sputum samples.

Eligibility criteria:
patients older than 18 years of age. ability to give informed consent. no medical contraindication to phlebotomy. epidemiologically at risk for tuberculosis or for an opportunistic infection. patients who can identify a responsible health care provider as someone willing to provide clinical information and to receive medically important information.

Keywords: communicable infection monitoring non-invasive tests opportunistic infection
efficacy of m640 in acute lumbosacral musculoskeletal conditions.

Conditions: Sciatica Acute; Lumbar Spinal Stenosis

Summary: the goal of this clinical trial is to learn if a modification to metaxalone 640 mg can reduce low back and leg pain. the participants will be 18 to 80 years old, healthy with newly occurring back or leg pain. the main question aims to compare a group taking active treatment and a group taking a look-alike substance containing no active treatment. all participants will answer questions on day 1, before treatment, and on 7-day after treatment, about: * amount and quality of pain * interference with physical activity * interference with sleep

double-blind, randomized, placebo-controlled, multi-center study of metaxalone 640 mg plus standard of care for patients with acute lumbo sacral musculoskeletal conditions with spinal stenosis and sciatica. participants will be randomized 1:1. following the initial pilot-study a second study will randomize a larger population of patients with appropriate power.

Eligibility criteria:
inclusion criteria: * no clinically significant conditions impacting quality or quantity of pain * baseline numeric pain scale ≥ 6 * capable of answering text or email survey reminders * low back pain with or without sciatica exclusion criteria: * current use of other skeletal relaxants * current use of other pain relievers * current use of cimetidine or monoamine oxidase inhibitors
development and validation of the patient-completed caprini risk score

Conditions: Venous Thromboembolism

Summary: the investigators aimed to test the reliability and validity of the chinese version of patient-completed crs in hospitalized patients and to evaluate whether this form can be widely used in clinical practice instead of only health care workers' evaluation.


Eligibility criteria:
inclusion criteria: * patients older than 18 years * patients with first admission to the medical and surgical units within 24 hours * willingness to participate in the study exclusion criteria: * patients with a diagnosis of pte or dvt on admission * patients with cognitive impairment * inability to read or write * patients with mental diseases * patients with visual impairment * refusal to cooperate

Keywords: vte risk caprini patient-complete validation
outcome and related factors of necrotizing fasciitis of the limb

Conditions: Necrotizing Fasciitis

Summary: soft tissue necrotizing fasciitis of limbs are lethal infections and associated with high morbidity and mortality rates. the purpose of this study is to determine the clinical manifestations and factors affected the treatment outcome to predict the prognosis and make timely decision for appropriate management and prevent limb loss.

patients that are admitted to hospital with the diagnosis of necrotizing fasciitis of a limb will be entered to this study. a questionnaire will be completed for each patient included demographic data, admission and diagnosis date, treatment onset, medical history for diabetes mellitus, hiv infection, use of immunosuppressor drugs, peripheral vascular disease, cancer, renal disease, intravenous drug abuse, and disease outcome that can be recovery, amputation or death.

Eligibility criteria:
inclusion criteria: * necrotizing fasciitis of the limb

Keywords: necrotizing fasciitis
the safety of boostrix following routine immunization of pregnant women

Conditions: Whooping Cough

Summary: the purpose of this study was to assess the safety of boostrix administered on or after the first day of the 27th week of pregnancy by conducting a post-marketing study that provided safety information to the public and healthcare providers. this was one of the largest cohorts of pregnant women vaccinated with boostrix in the u.s. through partnership between kaiser permanente southern california (kpsc) and the sponsor, glaxosmithkline (gsk), information about the safety of maternal vaccination with boostrix and maternal and infant adverse events (aes) in a community setting was gained.


Eligibility criteria:
inclusion criteria: * pregnant women with prenatal care and continuous membership (allowing up to a 31-day gap) at kpsc between the 1st day of the 27th week of pregnancy and the index (vaccination) date. * exposed cohort (from the 27th week of gestation): pregnant women vaccinated with boostrix on or after the 1st day of the 27th week of pregnancy; who were not vaccinated with any other tdap vaccine at any other time during the pregnancy in scope of this study. * unexposed cohort: women matched to the exposed cohort and pregnant sometime during the approximate estimated period between january 1, 2012-december 31, 2014 and did not receive any tdap vaccine during the pregnancy in scope of this study. for the analysis of congenital anomalies among live births, at birth and through six months of age, the following additional inclusion criteria for infants will be applied: * live born * born in kpsc hospitals note: pregnant women vaccinated with boostrix during pregnancy before the 27th week of gestation, with membership at the date of vaccination, and who were not vaccinated with any other tdap vaccine at any other time during the pregnancy in scope of this study will be part of a descriptive analysis (secondary objective).

Keywords: whooping cough, boostrix, tdap, safety, pregnancy, infants
neurostar tms therapy system: utilization and outcomes

Conditions: Major Depressive Disorder

Summary: the major objective of this observational study is to describe clinical outcomes of patients receiving treatment with the neurostar tms therapy system in routine clinical practice.


Eligibility criteria:
inclusion criteria: * major depressive disorder exclusion criteria: * contraindications to treatment with tms

Keywords: transcranial magnetic stimulation tms observational study major depression
a study to evaluate the consistency of oscillometry and spirometry test results in patients with confirmed or suspected asthma or copd

Conditions: Asthma/ COPD

Summary: the study to evaluate the consistency of oscillometry and spirometry test results in patients with confirmed or suspected asthma or copd, it is a multi-centre clinical study. sponsor by astrazeneca investment(china) co.,ltd.

800 patients, including suspected or confirmed asthma, suspected or confirmed copd, will be enrolled in nationwide multiple study centres. enrolling suspected and confirmed subject in an approximate1:1 rate in centre-level. about 100 subjects were enrolled at the leader site, while about 14 subjects were enrolled at other sites. to evaluate the consistency of oscillometry and spirometry test results in patients with confirmed or suspected asthma or copd.

Eligibility criteria:
inclusion criteria: participants are eligible to be included in the study only if all of the following criteria apply and signed informed content : suspected and confirmed asthma 1. participant must be≥18 years old. 2. present symptom such as wheezing, cough, chest tightness, shortness of breath, but not confirmed-asthma (without evidence of variable airflow restriction) or confirmed-asthma with evidence of variable airflow restriction (such as positive bronchodilation test, positive bronchial challenge test, variability \>10% in twice daily pef over 2 weeks, et al) suspected and confirmed copd 1 participant must be ≥40 years old. 2 present symptom such as chronic cough, sputum production, dyspnoea, but not confirmed-copd (without evidence of persistent airflow restriction) or confirmed- copd with evidence of persistent airflow restriction (post-bronchodilator fev1/fvc\<0.7) exclusion criteria: participants are excluded from the study if any of the following criteria apply: 1. any diseases that influence lung function result such as lung cancer, pneumonia, active pulmonary tuberculosis, pulmonary embolism and interstitial lung disease, etc; history of recent surgery that affect lung function results, including thoracotomy surgery, pneumothorax surgery, thoracic drainage, etc 2. contraindication to spirometry or oscillometry test, or allergic to bronchodilator. 3. currently pregnant or breast-feeding women 4. judge by the investigator if the participant is unlikely to comply with study procedures, restrictions, and requirements, will not be enrolled .
immune suppression and ventilator associated pneumonias

Conditions: Sepsis

Summary: patients in the icu are already predisposed to nosocomial infections, which are both costly and potentially life threatening, and it appears that the immune paralysis of sepsis may put these patients at greater risk for secondary infections, though this has not been proven conclusively. one measure of this sepsis-induced immune suppression is monocyte deactivation. the investigators hypothesize that, as a cornerstone of the monocytic innate immune response to infection, the inflammasome is critical to monocyte function during sepsis.

sepsis is a systemic inflammatory response to a severe infection. despite the high incidence and societal costs of sepsis, the mechanism by which it kills remains unclear. the pathophysiology of sepsis is not completely understood, but many investigators now believe that sepsis induces a prolonged state of immune suppression. this study will attempt to quantify the degree of immune suppression during the first 5 days of sepsis by measuring the immune function of peripheral blood monocytes and the inflammasome constituent proteins in peripheral blood monocytes and alveolar macrophages.

Eligibility criteria:
inclusion criteria: 1. ≥ 18 years. 2. have consensus criteria for sepsis (infection plus two of four systemic inflammatory response syndrome \[sirs\] signs \[tachycardia, tachypnea, fever or hypothermia, leukocytosis or leukopenia\]) and a known or suspected infection for septic arm. * patients without criteria for sepsis will be eligible for control arm. patient must consent to have blood drawn within 24 hours of initiation of mechanical ventilation (for control arm) and 24 hours of new episode of sepsis to be eligible (for septic arm). exclusion criteria: 1. consent not available or declined 2. prisoner 3. died before blood collected 4. onset of sepsis more than 24 hours prior to transfer to osumc,mechanical ventilation greater than 24 hours 5. anticipation of less than 24 hours of mechanical ventilation by primary team 6. women who are pregnant.
impact of neuropsychological alteration of patients with eating disorders

Conditions: Eating Disorder

Summary: eating disorders are multifactorial disorders currently conceptualized in a biopsychosocial model, but pathophysiology remains relatively unknown, and robust etiological models to guide treatment are therefore lacking. different endophenotypes and neurocognitive vulnerability factors have been found in eating disorders including decision making abnormalities. the investigators hypothesize that decision making abnormalities are associated with a lower level of functioning and quality of life which could lead to social and interpersonal difficulties. the investigators also hypothesize that these anomalies are associated with a particular clinical profile (more restrictive profile, more hyperactivity, less insight on the disease and desire for care ...).

the investigators will recruit a total of 200 patients with an eating disorder in the university hospital of montpellier. participation consists of a one-day visit with a multidisciplinary assessment. no action is specific to research. this is the usual management of patients with eating disorders addressed to our department.

Eligibility criteria:
inclusion criteria : * patient with an eating disorder according to dsm-v criteria * patient aged from 15 to 65 years * patient who performs the day-hospital evaluation * patient affiliated to a french social security system * patient able to understand the nature, the aim and the methodology of the study for minor one of the legal guardians gave his consent exclusion criteria: * patient in an unstable somatic state (eg severe metabolic disorder making impossible or unreliable neuropsychological assessments) * patient's refusal to participate * patient protected by law (guardianship or curatorship) * pregnant or nursing women. a dosage of βhcg will be performed to ensure the absence of pregnancy.

Keywords: anorexia nervosa bulimia binge eating disorders neuropsychology neurocognition daily functioning