Kornimate/medical-research-clean huggingface dataset:
a trial to investigate the effect of different supplements on fluid and sodium status in short bowel

Conditions: Short Bowel Syndrome

Summary: patients with short bowel intestinal failure are recommended to aim for a diet high in energy and protein. some patients have difficulties in achieving recommended intakes and additional nutrition may be provided by oral nutritional supplements. there is very little research completed on which is the best oral nutritional supplement for patients. the aim of the study is to see the effect different oral nutritional supplements have on your stoma or fistula output and levels of hydration.

after written consent is obtained, patients will be asked to fast from 12.00am on day one. at 08.00am patients will be asked to pass urine and to empty their stoma bag. after this they will be asked to drink 200ml of the ons which they have been randomised to test on day one over a 30 minute period. urine and intestinal output will be collected into two separate containers over the next 6 hours. during this time the patient will not be permitted to eat or drink other fluids. after 6 hours the patient will be able to eat and drink normally. the urine and intestinal output will be weighed and then an aliquot will be stored in a -20oc freezer before being sent for analysis. day two is a washout day when the patient will be able to eat and drink normally. day three will be the same as day one but the patient will have the other ons that they did not have on day one. no changes will be made to the patient's usual anti diarrhoeal and/or anti motility agents or parenteral support during the study.

Eligibility criteria:
inclusion criteria: * adult patients (\>18 years) * residual length of small bowel \<200cm determined either at operation or radiologically. * patients with a stoma or an established enterocutaneous fistula * normal hydration status (urinary sodium \>20mmol/l) exclusion criteria: * dehydration (urinary sodium \<20mmol/l) * patients with short bowel and a jejunocolonic anastomosis * current sepsis of any cause * addition/amendment to anti-diarrhoeal or anti motility agents in the last 3 days * severe gastrointestinal obstruction or structural abnormality of the intestine * active crohn's disease - assessed using two of the three parameters: creactive protein \>10 albumin \ 400 * participation in another intervention trial which may affect intestinal absorption * nil by mouth * unable or unwilling to provide consent
estimation of intrinsic positive end-expiratory pressure (peep) in acute respiratory distress syndrome (ards)

Conditions: Acute Respiratory Distress Syndrome

Summary: ards (acute respiratory distress syndrome) is a condition of severe inflammation and excess fluids in the lungs that impairs their function of oxygen uptake to the point of needing a ventilator (breathing machine) to help them obtain enough oxygen into the body. because of the high amounts of gas that the ventilator has to give to these patients, high pressures may develop deep into the lungs and produce complications for the patient. however, physicians sometimes cannot recognize it because it requires special equipment to measure pressure deep in the lungs. the goal of this study is to determine if the amount of this pressure can be calculated using mathematical formulas and the routine numbers provided by ventilators. the study consists on making the conventional measurement of this deep pressure and at the same time calculate this same pressure from other measurements that the ventilator routinely provides, to see if the calculated value can replace the more complicated conventional measurement. the measurements will be done by: 1. placing a small device along the tubing connecting the patient to the ventilator; 2. giving medicines to relax the muscles (if the patient is not already receiving them); and 3. making the ventilator hold the patient's breath for a few seconds to take measurements. this is repeated after the breathing rate of the ventilator is increased or decreased mildly. risks related to the medicine to be used and the measuring maneuvers are rare but include transient narrowing of windpipes, transiently low heart rate, blood pressure or blood oxygen, and allergic reactions. this is not a treatment. the information obtained during the study will be shared with the treating doctors who may find it useful to make adjustments to the ventilator. the patient may receive no direct benefit from being in this study; however, the findings may contribute to better care for this kind of patients in the future.

intrinsic peep (positive-end expiratory pressure) was measured by end-expiratory occlusion method and estimated using formulas derived from measured expiratory flows and a postulated linear pressure-flow relationship during expiration in passive ards patients. agreement between measured and estimated intrinsic peep was analyzed by bland and altman's method.

Eligibility criteria:
inclusion criteria: * patients 18 years of age or older with diagnosis of ards, as defined by the american- european consensus conference 4 * receiving mechanical ventilation. * presence of autopeep by inspection of flow-time waveforms displayed by the mechanical ventilator. exclusion criteria: * known or suspected diagnosis of copd or airflow limitation. * next of kin not available to consent. * contraindication to receive a muscle relaxant when measurements may be inaccurate without its administration. * pregnancy

Keywords: intrinsic peep
my scrivener® - measuring effectiveness and dose response in children

Conditions: Asperger's Syndrome; Dyslexia; Cerebral Palsy; Attention Deficit Disorder; ADHD; Traumatic Brain Injury; Stroke

Summary: this study will assess whether a computer haptic peripheral device programmed to provide repetitive motion training is as effective as the same repetitive motion training provided by a human being.

this study builds on a large body of neurological research that uses robot-guided repetitive motion training to induce neuroplasticity and improvements in upper extremity motor skills in adults and children. this research study is looking at handwriting, a fine-motor task that is used daily. in our study, we want to see if 3-dimensional robotic-assisted repetitive motion training can be a safe and effective intervention for school-age children with fine motor deficits arising from several different impairment origins. our research construct is: legible handwriting = function of (tactile feedback, visual feedback, duration, and fine-motor control). independent variables: * tactile feedback is a continuous variable of force-feedback measured in pounds of force. * duration is a continuous variable measured in seconds and number of repetitions. * visual feedback is the letter scribed on the paper. dependent variable: * legible handwriting will be measured by scoring on the test of handwriting skills and the print tool™ evaluation. * fine motor deficit/control will be measured directly and objectively by quantifying the error between the desired scribing task and the actual scribing task. the robotic device is an affordable (\<$200) computer haptic (the falcon(r)) that currently is approved by the fcc for home and office. it is \*not\* approved for medical use. this is an investigational, nonsignificant risk device.

Eligibility criteria:
inclusion criteria: * meet the following base prerequisites for writing: orientation to written language; eye-hand coordination, single handed utensil or tool manipulation (bamf score \>= 6), recognize all letters of the alphabet (unless the child has dyslexia). * children have illegible printing for their grade, or legible printing but a speed less than the norms for their grade and sex. * be able to grasp a pen. * be able to speak and understand english. * be able to follow instructions. * be able to devote at least 20 minutes to the assigned tasks (short breaks will be allowed). * be enrolled in school at grade k or above. * a score lower than 80% on the print tool™ or the cursive tool. exclusion criteria: * unable to pass the informed assent screener. * unwilling to sign or mark the informed assent documents. * uncontrolled spasticity. * a bamf score lower than 6 (includes severe paralysis of the upper extremity). * cerebral palsy other than hemiplegia cerebral palsy * severe autism or intellectual disabilities that prevent productive interactions with the investigator

Keywords: haptic rehabilitation fine-motor skill handwriting
investigating the use of fluorescence imaging in endometrial cancer surgery

Conditions: Endometrial Cancer

Summary: the main purpose of the study is to evaluate the detection rate and accuracy of fluorescence imaging in endometrial cancer staging by sentinel node assessment.

in many cancer types, such as breast cancer and melanoma, sentinel node assessment has become the standard of care surgical treatment. sentinel nodes are the first lymph nodes to which cancer cells are likely to spread from a primary tumor. removal of a sentinel node for examination accurately predicts whether the cancer has spread to other nodes further along in the nodal chain. fluorescence imaging with icg dye (indocyanine green) has been used to detect lymph nodes in patients with gastric, colorectal and breast cancer. to date, the use of this technique in endometrial cancer has not been reported.

Eligibility criteria:
inclusion criteria: * biopsy proven endometrial carcinoma * must have planned to undergo standard endometrial cancer staging surgery as part of their routine clinical care * must be 18 years of age and older * must be able to comply with all the study procedures exclusion criteria: * significant liver disease, cirrhosis or liver insufficiency with abnormal liver function tests, with total bilirubin \> 1.5 times normal, and/or sgot \> 2 times normal * uremia, serum creatinine \> 2.0 mg/dl * previous history of adverse reaction or allergy to icg dye, iodine, shellfish, or iodine dyes * previous lymphadenectomy or surgery that could change the uterine lymphatic drainage * pregnant * currently participating in a drug, biologic and/or device treatment study * any medical condition that would normally prevent someone from receiving general anesthesia or undergoing standard surgical procedures

Keywords: cancer of endometrium cancer of the endometrium carcinoma of endometrium endometrial carcinoma endometrium cancer neoplasms, endometrial
rc48 plus ak105 and cisplatin in advanced gastric cancer

Conditions: Advanced Gastric Carcinoma; HER2-positive Gastric Cancer

Summary: to explore the safety and clinical efficacy of cisplatin combined with rc48 and anti-pd-1 antibodies ak105 in her-2 positive advanced gastric cancer.

although anti-pd-1 antibody could prolong the survival of patients with adanced gastic cancer, there are relatively few reports on anti-pd-1 antibody therapy in her2-positive gastric cancer. rc48 is a primary anti-her2 antibody-drug conjugate, which has been approved by the chinese nmpa for the later-line treatment of her2-positive gastric cancer. this study was to explore the safety and clinical efficacy of rc48 combined with cisplatin and ak105 in previously untreated patients with her2-positive gastric cancer.

Eligibility criteria:
inclusion criteria: * age ≥18 years old, ≤75 years old, regardless gender * pathologically confirmed gastric adenocarcinoma, her2 immunohistochemical examination of 2+ or 3+ * ecog ps scores 0-1 * stage iv according to ajcc 8.0 and no systemic therapy previously * expected lifespan ≥ 3 months * adequate organ function * at least one measurable lesion according to recist 1.1 * asymptomatic intracranial metastasis * no history of other malignancies * women of childbearing age must have a negative blood pregnancy test within 7 days, and subjects of childbearing age must use appropriate contraception during the trial and for 6 months after the trial * agreed to participate in this clinical study and signed the informed consent exclusion criteria: * currently participating in an interventional clinical investigational treatment, or have received other investigational drugs or treatment with an investigational device within 4 weeks prior to the first dose * received anti-pd-1, anti-pd-l1, anti-ctla-4, and other checkpoint inhibitor * received traditional chinese medicines or immunomodulatory drugs with anti-gastric cancer indications within 2 weeks before the first administration * active autoimmune diseases or immunodeficiency diseases * allergy to any test drug and its excipients, or a history of severe allergy, or contraindication to the test drug * severe mental disorder * receiving systemic corticosteroids within 7 days prior to the first dose of the study * clinically apparent cardiovascular and cerebrovascular disease * others investigators evaluated not meet the inclusion criteria
ripc on activity, fatigue and gait in ms

Conditions: Multiple Sclerosis

Summary: this study evaluates whether remote ischaemic preconditioning (ripc) can improve activity, gait and fatigue in people with multiple sclerosis. half the participants will receive ripc, the other half will receive a sham treatment.

regular physical activity has been shown to improve physical fitness, fatigue, quality of life, and reduce the progression of disability in people with multiple sclerosis (ms). however, people with ms are less physically active than others. this is partly due to poor exercise tolerance and fatigue. remote ischemic preconditioning (ripc) is the exposure of a limb to brief periods of circulatory occlusion and reperfusion by inflating pressure cuffs around arms or legs to above systolic pressures (mmhg), to protect organs against ischaemic injury. ripc has been shown to improve exercise performance and delay fatigue in athletes. however, there is little to no research examining the effect of ripc on walking or exercise performance in ms patients. the aim of this trial is to assess whether ripc can improve activity, gait and reduce fatigue in people with ms.

Eligibility criteria:
inclusion criteria: * diagnosis of ms as per the mcdonald's criteria * sufficient cognitive ability and understanding of the english language to give informed consent and complete study questionnaires * ability to walk for 6 minutes without rest * resting systolic bp of more than 100mmhg * resting systolic bp of less than 170mmhg exclusion criteria: * cognitive difficulties or insufficient english to allow understanding of consent and study questionnaires * inability to walk * other systemic illness affecting exercise tolerance * resting systolic bp of less than 100mmhg * resting systolic bp of 170mmhg or more

Keywords: remote ischaemic preconditioning gait analysis activity fatigue
perioperative adverse cardiovascular event in type-2 diabetic patients

Conditions: Type 2 Diabetes; Neuropathy

Summary: the study was designed to investigate the correlation between perioperative adverse cardiovascular events and the degeneration of sensory nerves in patient diagnosed with type 2 diabetes mellitus, undergoing elective non-cardiac surgery.

the study was designed to investigate the correlation between perioperative adverse cardiovascular events and the degeneration of sensory nerves in patient diagnosed with type 2 diabetes mellitus, undergoing elective non-cardiac surgery. diabetes mellitus and peripheral sensory nerve degeneration will be diagnosed via clinical evaluation. serum levels of constituent neuropeptides, including neuropeptide y (npy), calcitonin and substance p (sp) and calcitonin gene related peptide (cgrp), and transient receptor potential vanilloid 1 (trpv1), a molecular nociceptor in peripheral sensory nerves will be quantitatively evaluated. the clinical and the biochemical consequence will be compared between the cohorts of diabetic and non-diabetic patients. the differences and the correlations will be analyzed. the results of the study may reveal whether or not the perioperative adverse cardiovascular events in diabetic patients are correlated with degeneration of peripheral sensory nerves and the alterations in the neuropeptides and trpv1 are potentially applicable for evaluation of the risk of cardiovascular events in perioperative period in diabetic patients.

Eligibility criteria:
inclusion criteria: * the main discharge diagnosis is t2dm； * age \> 18 years old; * no acute complications of diabetes exclusion criteria: * t1dm patients; * egfr \< 60 ml/min/1.73 m or proteinuria (or both); * patients with history of acute cardiovascular events; * familial hypercholesterolemia or other hereditary lipid metabolism diseases; * anti-hiv patients; * patients with serious mental health problems; * patients receiving drugs that can lead to dyslipidemia, such as antipsychotics, corticosteroids, or immunosuppressants; * patients with systemic inflammatory diseases, such as systemic lupus erythematosus; * patient are quitting smoking and severe obesity (bmi\>40)

Keywords: diabetes mellitus adverse cardiovascular events nerve degeneration peripheral sensory nerves
prospective patient registry for radiation oncology techniques and quality

Conditions: Solid Tumors; Cancer

Summary: this study will create a patient data registry to collect and analyze information on technology usage and outcomes among patients receiving a broad range of relatively new radiation treatments that have become standards of care in our practice. review of this information will serve as a basis for development of better patient management plans, to inform decisions about acquisition of new technologies, to provide information about quality in our care delivery, and to create a database that will securely warehouse ongoing information about what treatments the patients we serve need most and the challenges they face in the treatment process. the information gathered is likely to not only improve our services at the university of maryland and its community sites but to advance medical science and enhance the quality of care for cancer patients.

the purpose of this study is to create a robust and long-term patient data registry containing limited demographic, diagnostic, treatment, and follow-up data on patients at the study sites undergoing one or more of the following radiation treatments/technologies: brachytherapy, including high-dose-rate and low-dose-rate techniques/ gammapod therapy/ grid treatment/ image-guided radiation therapy/ intensity-modulated radiation therapy and intensity-modulated arc therapy/ mammosite and savi applicator/ photodynamic therapy/ proton therapy/ sir spheres and radiolabeled microsphere therapy/ stereotactic radiosurgery and stereotactic body radiotherapy/ thermal therapy (hyperthermia)

Eligibility criteria:
inclusion criteria: * patients who are 18 years old or older and scheduled to undergo any of the listed radiation treatment technologies at the university of maryland medical center or one of its community sites as included in this protocol provided s/he consents to participate. exclusion criteria: * patients who are incarcerated or in legal custody are not eligible for this study. * patients who are younger than 18 years, are cognitively impaired, or are otherwise unable to provide informed consent. * patients who are pregnant

Keywords: patient registry radiation oncology technology assessment
study of gene activity in fat and muscle in diabetics and healthy controls

Conditions: Healthy; Type 2 Diabetes; Endotoxemia

Summary: the aim of the present protocol is to study gene activity in fat and muscle tissue in type 2 diabetics and healthy volunteers after injection of e. coli endotoxin.we hereby hope to gain insight in some mechanisms behind the association between inflammation and insulin resistance.

numerous studies have shown an association between low-grade inflammation and insulin-resistance in type 2 diabetics. it is also well-known that septic patients often develop insulin-resistance. the pathogenetic mechanisms behind the association between inflammation and insulin-resistance is not fully understood. in this study we create an experimental inflammation by giving e. coli endotoxin 0,3 ng/kg iv to type 2 diabetics and healthy controls. muscle biopsies are taken at 0, 2, 4 and 6 hours after injection, while fat biopsies are taken 0, 2, 4, 6 and 8 hours after endotoxin. mrna for adiponectin, leptin, ppar-gamma, pgc-1, pai-1 and cytokines in tissue is later measured by rt-pcr. blood samples are drawn on an hourly basis until 8 hours after endotoxin injection for common biochemical analyses including white blood cell count. plasma is spared and later analyzed for cytokines, pai-1 and vcam-1/icam-1.

Eligibility criteria:
inclusion criteria: * healthy * type 2 diabetes exclusion criteria: * heart failure * lung disease * anti-coagulation treatment

Keywords: low-grade inflammation insulin resistance metabolism type 2 diabetes endotoxemia fat tissue muscle tissue rt-pcr
validation of the 3d-cam turkish version

Conditions: Delirium; Validity

Summary: 3d cam into turkish validity and reliability on postoperative delirium will be test as a prospective diagnostic study. after approval by dr. edward r. marcantonio, (15) will translation and back-translation. the original 3d-cam will translate into turkish by two medical doctor .the two translational versions will be discussed and merged into a final version. back translation will performed in regardless of any information from its original version by another two medical doctor. both the translated and back translated versions will sent to dr. marcantonio for approval. eligibility and the documentation of consent will be confirmed at the preoperative visit. during this visit, patients will provide demographic and historical medical information, including information regarding medication usage. the mini-mental state exam (mmse) will be performed. delirium assessment delirium assessment with the 3d-cam before the study period, all researchers will participate online training program on 3d cam. delirium will be evaluated using the 3d cam every each morning and evening (18:00-20:00) for postoperative 3 days. delirium assessment with the dsm-5 the psychiatrist investigator who was blinded to the 3d-cam assessment results, will evaluate the patients according to the criteria of dsm-5 within 3 min after the 3d-cam assessment.


Eligibility criteria:
inclusion criteria: * 18 years and older * asa physical status 1-3 * admitted to the icu after surgery with a predicted length of stay for more than 48 h * mmse ≥ 20 (to exclude dementia) exclusion criteria: * refused to participate * patients with severe visual or auditory disorder/handicaps or endotracheal intubation which might impede communication * presence of a major psychiatric condition such as bipolar disorder, major depression, schizophrenia, alzheimer or dementia, parkinsonism * deep sedation or coma * asa physical status iv or v