Kornimate/medical-research-clean huggingface dataset:
low glycemic load diet in patients with stage i-iii colon cancer

Conditions: Stage I Colon Cancer; Stage II Colon Cancer; Stage III Colon Cancer; Stage I Rectal Cancer; Stage II Rectal Cancer; Stage III Rectal Cancer

Summary: this pilot clinical trial studies the feasibility of a low glycemic load diet in patients with stage i-iii colon cancer. a low glycemic load diet includes foods that have low scores on the glycemic index. the glycemic index is a scale that measures how much a certain carbohydrate causes a person's blood sugar to rise. a low glycemic load diet may help decrease the chance of cancer coming back and improve the survival in patients with colon cancer.

primary objectives: i. to determine the feasibility of following a low or medium glycemic load diet in patients with stage i-iii (local-regional) colon cancer. secondary objectives: i. to determine patient-reported acceptability of diet. ii. to determine nutritionist resources utilized. iii. to evaluate the effect of lowering dietary glycemic load on body mass index (bmi), lipid metabolism and pro-oncogenic intermediaries of cellular metabolism. outline: patients are sequentially enrolled in 1 of 4 possible cohorts as needed based on the feasibility of the prior cohort. cohort 1: patients follow a low glycemic load diet with standard dietary intervention (contact with nutritionist in person every 2 weeks with phone contact on the alternating weeks) for 12 weeks. cohort 2: patients follow a low glycemic load diet with intensified dietary intervention (contact with nutritionist in person every week) for 12 weeks. cohort 3: patients follow a medium glycemic load diet with standard dietary intervention for 12 weeks. cohort 4: patients follow a medium glycemic load diet with intensified dietary intervention for 12 weeks.

Eligibility criteria:
inclusion criteria: * patients must have stage i-iii colon or rectal cancer and have undergone definitive therapy; definitive therapy may have included surgery alone, or surgery plus neoadjuvant and/or adjuvant therapy * patients must regularly consume a diet with a glycemic load \> 150 as estimated through the 3 day food recall * patients must readily be available for a 3 month period and agree to participate in regular dietary adherence assessments (surveys and phone interviews) exclusion criteria: * current participation in an intervention targeting diet or exercise
dawn simulation and postural hypotension

Conditions: Orthostatic Hypotension

Summary: one of the most physiologically demanding things that older people do every day is to get up in the morning. after spending a night laying flat, where the blood distributes evenly across the body, when they stand in the morning (and the blood rushes to their feet), their cardiovascular system may not be able to compensate and maintain blood flow to the brain. this phenomenon is known as orthostatic or postural hypotension. the investigators have found in a group of young individuals that use of a dawn-simulation light that gradually wakes the brain is able to increase cardiovascular tone prior to arising. the goal of this experiment is to determine whether this dawn simulation light is able to increase cardiovascular tone in older adults such that they would have reduced or absent postural hypotension when they awaken in the morning. this would greatly reduce the risks of falls and their associated morbidities in older adults.


Eligibility criteria:
inclusion criteria: * history of falls or dizziness at exit from bed in the morning (at least two incidents in the past year) * at least 20/200 corrected visual acuity * stable health * normal hearing exclusion criteria: * regular cigarette smoker * alcohol abuse * drug abuse
endoscopic treatment for local residual neoplasia

Conditions: Colorectal Cancer

Summary: endoscopic mucosal resection (emr) is considered to be a gold standard of therapy of colorectal lateral spreading tumors (lst) without significant risk for lymphatic spread. according to the investigators previous study, local residual neoplasia (lrn) after conventional endoscopic mucosal resection (emr)occurs in up to 21% of cases. endoscopic therapy of lrn was not sufficient in 53 % and has not been standardized yet.


Eligibility criteria:
inclusion criteria: * patients older than 18 years * patients with local residual neoplasia in scar in three months after endoscopic mucosal resection for laterally spreading tumor (0-iia \> 10 mm) * signed informed consent exclusion criteria: * incomplete endoscopic mucosal resection * previous therapy for local residual neoplasia * difficult or impossible localization of post-emr scar

Keywords: colorectal cancer laterally spreading tumors endoscopic mucosal resestion local residual neoplasia
clarithromycin-based triple therapy for 14 days versus sequential therapy 10 days in the first line therapy

Conditions: Eradication Rates of the Two Regimens

Summary: the investigators aimed to compare the eradication rates of sequential therapy for 10 days versus triple therapy for 14 days


Eligibility criteria:
inclusion criteria: * patients are aged greater than 20 years who have h. pylori infection without prior eradication therapy and are willing to receive the sequential therapy will be eligible for enrollment. * written informed consents will be obtained from all patients prior to enrollment. exclusion criteria: patients will be excluded from the study if any one of the following criteria is present: * children and teenagers aged less than 20 years, * history of gastrectomy, * gastric malignancy, including adenocarcinoma and lymphoma, * previous allergic reaction to antibiotics (amoxicillin, clarithromycin, levofloxacin, metronidazole) and prompt pump inhibitors (lansoprazole), - contraindication to treatment drugs, * pregnant or lactating women, * severe concurrent disease * patients who cannot give informed consent by himself or herself.

Keywords: h pylori, eradication
circulating myokine levels and bone metabolism

Conditions: Osteoporosis, Postmenopausal

Summary: circulating levels of several myokines will be measured in serum samples obtained from women in various categories of bone density and according to the presence of fracture or not as well as before and after treatment with teriparatide and denosumab

serum samples for the measurement of several myokines will be obtained from: 1) equal groups of premenopausal women with normal bmd, postmenopausal women with normal bmd, postmenopausal women with osteopenia, and postmenopausal women with osteoporosis; 2) women with hip fracture compared with controls (women subjected to surgery due to knee osteoathritis); 3) women with osteoporosis treated with teriparatide or denosumab for 12 months

Eligibility criteria:
inclusion criteria: substudy 1: • adult women substudy 2: • postmenopausal women with an incident hip fracture substudy 3: • postmenopausal women with osteoporosis exclusion criteria: * secondary osteoporosis * any disease that could affect muscle and/or bone metabolism * any medication that could affect muscle and/or bone metabolism
a combination mindfulness and music intervention for acute pain

Conditions: Pain; Acute Pain

Summary: this project is a single-site, four-arm, randomized controlled trial evaluating a combination mindfulness + music intervention on acute pain among patients in an orthopedic clinic waiting room. participants will be randomized to one of four conditions: 1) a 5-minute mindfulness recording, 2) a 5-minute mindfulness recording with an accompanying sustained tone at 65.41 hertz, 3) a 5-minute mindfulness recording with an accompanying binaural beat set at 65.41 hertz in the left ear and 69.41 hertz in the right ear, or 4) a 5-minute mindfulness recording with an accompanying binaural beat set at 65.41 hertz in the left ear and 69.41 hertz in the right ear as well as instrumental, theta wave music.


Eligibility criteria:
inclusion criteria: * being 18 years of age or older * receiving pain treatment at tallahassee orthopedic center * understanding english instructions fluently exclusion criteria: * unable to consent because of physical or mental incapacity.

Keywords: mindfulness
the effect thirsty and oral care frequency of cold water

Conditions: Thirst

Summary: surgical patients, and especially bariatric patients, are high-risk patients who may develop thirst due to intubation, blood loss, osmotic imbalance, and prolonged fasting. nurses often have the perception that when the patient's oral intake is turned off, nothing can be done to prevent thirst and dry mouth. thirst is one of the main stress factors that reduces the comfort of intensive care patients. so far, no assessment has been routinely used to assess thirst and dry mouth. however, thirst is a mitigable symptom that should be evaluated by the nurse.

the data were collected by the researcher by face-to-face interview technique between april 2022 and march 2023 in the groups participating in the study. it was applied to patients who agreed to participate by giving information about the purpose of the study to patients who met the research criteria. the patients were divided into 2 groups as study and control. in the study group, the intensive care oral care frequency assessment scale was applied to 55 patients at the end of the 16th hour, in addition to the assessment of pain and thirst at the 1st, 4th, 8th, and 16th hours postoperatively. it was applied to patients with a thirst of 3 and above by spraying cold water into the mouth of the patient every hour. the standard oral care of the clinic was applied to the patients who needed oral care. in the control group, standard nursing care was applied to 55 patients with the pain, thirst and intensive care oral care frequency assessment scale at the 1st, 4th, 8th, and 16th hours postoperatively.

Eligibility criteria:
inclusion criteria: * be between the ages of 18-65, level of consciousness (level a of avpu) and orientation (place, direction, time) swallowing and coughing reflex without nausea-vomiting no mandible fracture no dialysis treatment when we ask about their thirst, those who have 3 or more thirst on a scale of 0-10 hungry for more than 6 hours anesthesia duration exceeding 1 hour patients not receiving mechanical ventilator support undergoing elective surgery individuals who can communicate at a level that can answer the research questions will be included. those who do not use dentures exclusion criteria: * be over 65, under 18 having lesions on the oral mucosa and lips having any disease that prevents communication such as alzheimer's, dementia patients with a thirst feeling of 3 or less during the cold spray application

Keywords: postoperative period ice nursing thirst intensive care units mouth
a study to evaluate safety and efficacy of pbk_m2101

Conditions: Intestinal Disease; Colonic Diseases; Gastrointestinal Disease; Digestive System Disease

Summary: this clinical trial was prospective, randomized, single-blind, 3-treatment arm, parallel treatment group, and active-controlled. , multi-center, phase 3 confirmatory clinical trial.


Eligibility criteria:
inclusion criteria: * patients who is informed and give a consent in voluntary * patients who is scheduled a esophagogastroduodenoscopy and colonoscopy * bmi 19≤and\<30 exclusion criteria: * patients who participate in other interventional study or had participated within 30 days before screening * pregnant or breast-feeding women who do not want to stop breast-feeding * uncontrolled hypertension * uncontrolled diabetes * fluid or electrolyte (na, k, ca, mg, chloride, bicarbonate) disturbance * hiv infection and/or chronic hepatitis b or c * patients who has a difficulty to participate because of severe nausea or vomiting * history of colon surgery and abdominal surgery within 6 month; need an emergency surgery
mypeeps mobile plus: a multi-level hiv prevention intervention for young msm

Conditions: HIV/AIDS

Summary: mypeeps mobile plus, a multi-level intervention for improving hiv prevention outcomes in ymsm, is a novel and evidence-driven approach using mobile technology to deliver hiv prevention information specifically developed for ymsm. building on strong preliminary work, the proposed research is the next logical step in a body of work designed to assess whether refinement of this mobile intervention used in combination with virtual prep peer navigation will result in improvements in prep uptake and a reduction in hiv-related behavior. this is key to advancing hiv prevention among hiv-negative us persons at extremely high-risk for hiv seroconversion.

this study expands mypeeps mobile to develop mypeeps mobile plus, a multi-level intervention comprised of mypeeps mobile with added prep content (based upon expert advisory and youth feedback) + prep e-peer navigation to overcome the challenges of prep initiation, adherence, and persistence among ymsm. peer navigation is an evidence-based, widely recommended intervention for reaching youth and msm for hiv-related care outcomes, with evidence of acceptability among racial/ethnic minority ymsm for prep. peer navigation addresses common reasons for failing to begin or maintain prep use, including low perceived risk, structural or logistic barriers to care engagement, and anticipated side effects. relative to in-person and group-based hiv prevention programs, behavioral interventions with digital and virtual components can have vast reach and present unique potential to rapidly scale delivery to very large and hidden groups. therefore, the investigators propose to conduct a randomized controlled trial to test the efficacy of mypeeps mobile plus (a multi-level intervention comprised of mypeeps mobile + prep e-peer navigation) for promoting initiation, adherence, and persistence of prep and decreased hiv risk behavior in ymsm. building upon the team's demonstrated ability to enroll large numbers of young racially and ethnically diverse ymsm and extensive experience developing mobile health interventions, the proposed study will test the efficacy of this expanded, multi-level mobile hiv prevention intervention emphasizing prep. if efficacious, it will increase prep initiation, adherence, and persistence and decrease overall hiv risk in diverse ymsm in the us.

Eligibility criteria:
inclusion criteria: * 17-25 years of age * identify as male, non-binary, or genderqueer * male sex assigned at birth * understand and read english * own a smartphone * report condomless anal sex with a male in the past year * hiv-negative (oraquick verified) exclusion criteria: * hiv positive * if study staff determine participant unable to consent due to obvious and severe cognitive impairment or under the influence of drugs or alcohol * transgender identity * currently report consistent use of prep

Keywords: prep care navigation
a 2 year trial of patients with type 2 diabetes focusing on cardiovascular diagnostics and metabolic control

Conditions: Type 2 Diabetes Mellitus

Summary: the purposes of this study are: * to investigate the extent of cardiovascular complications in a representative cohort (n=135) of adult patients with type 2 diabetes; * to examine if modern non-invasive assessment can replace invasive assessment; * to determine the effects of a 6 month lifestyle interventional program on weight, glycemic control and lipids in 60 patients; * to determine the effect of a 2-year prospective, randomised multi-interventional program (n=120) on cardiovascular risk, anthropometric measures and glycometabolic control; and * to investigate inflammatory markers in this setting.

as cardiovascular disease often is silent in type 2 diabetic patients, ways of detecting this early is of potential benefit, as is probably an aggressive treatment regimen trying to achieve goals for factors such as blood pressure, glycemic control, lipids, smoking, physical activity and weight. this study compares traditional non-invasive tests such as stress-ecg, modern non-invasive tests such as holter-analysis, modern ecg analysis, stress-ecco cardiography and tissue doppler against the gold standard today for assessing coronary artery disease, coronary angiography, in patients with type 2 diabetes and at least one cv-risk factor (i.e smoking, premature familial coronary artery disease (cad)), hypertension) irrespective of symptoms or signs of cad. the participants are included in a randomized-control trial for 2 years where one arm receives standard treatment and one receives treatment after a multi-interventional program. end-points include: glycemic control, lipid control, weight control, blood pressure control, and effects on inflammatory parameters.

Eligibility criteria:
inclusion criteria: * type 2 diabetes * ages 18-75 years * men and women * at least one cardiovascular risk factor (i.e hypertension, dyslipidemia, smoking/formerly smoker, premature familial coronary artery disease \[cad\], microalbuminuria) * written informed consent given exclusion criteria: * unwillingness * age \ 75 years * unstable cardiovascular condition * unstable medical condition

Keywords: type 2 diabetes mellitus cardiovascular coronary artery disease glycemic control treatment diabetes mellitus
remote ischemic conditioning for the treatment of stroke-related insomnia

Conditions: Acute Ischemic Stroke

Summary: this study intends to further reveal the effect of ric in stroke-related insomnia and explore its potential mechanisms.

sleep disturbance after stroke is an important factor affecting the prognosis of stroke function. at present, most studies have focused on the diagnosis and treatment of sleep disordered breathing after stroke, while stroke-related insomnia has been neglected. therefore, it is of great significance to explore a treatment that combines stroke protection with sleep improvement. remote ischemic conditioning (ric) triggers endogenous protective effect through transient and repeated ischemia in the limb to protect remote tissues and organs. the mechanisms of lric involve the regulation of autonomic nervous system, release of humoral factors, improvement of vascular endothelial function and modulation of immune/inflammatory responses, which participate in the regulation of sleep after stroke.therefore, this study intends to conduct a randomized controlled trial to further reveal the effect of ric in stroke-related insomnia and explore its potential mechanisms.

Eligibility criteria:
inclusion criteria: * aged 18 to 70 years old; * mrs≤3; * meeting the dsm-iv diagnostic criteria for insomnia: in the past one month, the presence of any of the following symptoms: a. have difficulty falling asleep (sleep latency \>30 minutes); b. have trouble in maintaining sleep; c. early awakening, accompanied by impaired daytime function, with symptoms occurring more than three times a week, lasting at least 2 weeks; * written informed consent provided by the patients or their legal relatives. exclusion criteria: * chronic insomnia (psqi≥8) or other sleep disorders was diagnosed 3 months before onset of stroke; * presence or past history of neuropsychiatric diseases such as epilepsy, brain tumors, neurodegenerative disorders, restless leg syndrome, periodic leg movement; * schizophrenia, significant anxiety and depression (hama≥14 points, hamd≥17 points) with moderate to high suicide risk, etc; * serious infection, malignancy, and other serious medical conditions (acute heart, liver, renal failure and other diseases); * have taken any medications (antipsychotics, hypnotics, antidepressants, etc.) that interfere with sleep in the latest two weeks; * have work shift or jet lag experience 4 months before enrollment infants, pregnant or lactating women.

Keywords: remote ischemic conditioning acute ischemic stroke insomnia
assessment of severity and prognosis in elderly patients with copd and complex chronic comorbidities

Conditions: COPD

Summary: cigarette smoking, the major risk factor for chronic obstructive pulmonary disease (copd), causes systemic effects, such as systemic cellular and humoral inflammation, that could substantially contribute to the development of chronic diseases, other than copd, mainly cardiovascular diseases and metabolic disorders. such chronic comorbidities affect health outcomes in copd, particularly in terms of disease severity and prognosis. the aim of the project is to investigate the prevalence of chronic comorbidities associated with copd and their impact on prognosis in elderly patients.

the investigators will recruit 100 outpatients, heavy smokers (20 pack/years), older than 65 years, diagnosed with copd. copd is defined by presence of fixed airflow limitation: post-bronchodilator forced expiratory volume at one second (fev1)/forced vital capacity (fvc) less than 70% according to spirometry classification from global inititiative for obstructive lung disease (gold) guidelines. each patient will be characterized by medical history, physical examination, and smoking history. each patient will perform pulmonary function test, including reversibility to inhaled bronchodilator (400 mcg albuterol), and 6-minute walk test. arterial blood gases and routine blood test, including inflammatory biomarkers, will also examined. in addition, each patient will undergo chest x-ray, thorax ct scan, echocardiography, and carotid ultrasonography. at enrollment, all patients will be in stable condition (no changes in medication dosage or frequency, no copd exacerbation or hospital admissions in the previous 4 weeks). clinical and biological follow-up will be prospectively followed for 3 years.

Eligibility criteria:
inclusion criteria: * caucasians * age \> 65 years * smoking history \> 20 pack/years (current or former smokers) * diagnosis of copd according to gold 2010 * stable condition exclusion criteria: * history of bronchial asthma * other chronic diseases such as interstitial lung disease, bronchiectasis, bronchiolitis obliterans organizing pneumonia (boop), pulmonary tuberculosis, cystic fibrosis * malignancies for which patient is being treated with radiotherapy or chemotherapy * acute events and/or hospitalization within 12 weeks prior to screening

Keywords: smoking dyspnea