Kornimate/medical-research-clean huggingface dataset:
assessing cirrhosis quality of care while accounting for cost

Conditions: Liver Cirrhosis

Summary: the objective of this study is to determine what influences the patient and caregiver perception of care, and if this perception associates with the percentage of and what quality metrics are being met and outcomes. the investigators also plan to capture the cost of providing quality metrics and the cost of monitoring adherence to quality metrics.

this study will be conducted using mixed-methods. the qualitative part will consist of in person, 1:1, open ended in depth interviews using a standard interview guide with probes. the quantitative part will document subjects meeting or not meeting the quality metrics supported by strong evidence, clinical outcomes, and medical bills.

Eligibility criteria:
inclusion criteria: * primary liver cirrhosis * receiving care at the study cite * no evidence of hepatic encephalopathy if the subject is providing consent exclusion criteria: * no documentation of cirrhosis * unable to confirm diagnosis of cirrhosis by imaging or pathology
effects of purple vegetables on cardiovascular disease (cvd) risk factors

Conditions: Hypertension; Hypercholesterolemia; Type II Diabetes; Obesity; Inflammation

Summary: the hypothesis is that richly coloured purple vegetables, rich in polyphenolic compounds including anthocyanins will have higher antioxidant and other biological activities, than more lightly coloured versions of these foods. diets of human subjects will be modified to allow consumption of 200-300 g of raw carrots or cooked potatoes. participants will be randomized to consume either orange or purple carrots, or white or purple potatoes. they will consume these diets for 12 weeks and bioavailability of polyphenolics will be examined as well as anthropometry and blood biochemistry for changes in risk factors associated with cardiovascular disease.


Eligibility criteria:
inclusion criteria: * adult men and women 18-65 years of age * must have a least one of the following risk factors associated with increased risk of type ii diabetes and/or cardiovascular disease: * borderline high or hypertension or undergoing treatment for such * abnormal fasting blood glucose or undergoing treatment for such * overweight or obese * borderline high or high ldl-cholesterol or undergoing treatment for such * borderline low or low hdl-cholesterol * borderline high or high triglycerides or undergoing treatment for such exclusion criteria: * smokers, pregnant or nursing women

Keywords: anthocyanins antioxidant polyphenols bioavailability cholesterol insulin sensitivity glucose tolerance atherosclerosis metabolic syndrome
translation of pritikin program to the community

Conditions: Metabolic Syndrome; Obesity; Weight Loss; Hypertension; Hypercholesterolemia; Hypertriglyceridemia

Summary: the broad, long-term aims of this scope of work are to investigate the effects of the pritikin program to the general population. the study will test the effects on individuals from the community with dysfunctional lipids, blood pressure and glycemic control. to assess the effectiveness of the pritikin program in the community, the effects of pritikin lifestyle intervention on overall health will be investigated.


Eligibility criteria:
inclusion criteria: * dysfunctional lipids, blood pressure and glycemic control determined at a screening visit: * triglycerides \> 150 mg/dl or hdl \<50 in females, \<40 mg/dl in males * systolic blood pressure ≥130 mmhg or diastolic blood pressure ≥80 mmhg (or on hypertension medication) * hba1c ≥5.7% or higher * no diagnosis or treatment for cancer in the past year * no diagnosis of mild cognitive impairment or dementia in the past year * ability to perform daily exercise, including aerobic activity and resistance exercise * non-smoker in the past year exclusion criteria: * positive exercise stress test

Keywords: metabolic syndrome obesity
hepatitis c patient management and family health education

Conditions: Hepatitis C

Summary: introduction: hepatitis c virus (hcv) is recognized as the leading cause of chronic liver disease worldwide. however, the screening rate and treatment rate of hcv-infected patients in china is low, which increases the burden of patients and the infection risk of their family members. wechat, an instant messaging software, is used in a very high proportion in china. health promotion based on wechat public platform is a very convenient and effective way of health education. therefore, this study plans to apply wechat to conduct health intervention for hcv-infected patients. the objective is to explore the effect of we-media-based health promotion method on the detection rate and treatment rate of hcv-infected and their family members. method: recruitment will be conduct in 10 hospitals in jilin, beijing, henan and anhui provinces. the subjects should be patients new diagnosed with hepatitis c at the hospital and aged 18 to 69. after signing the consent form, eligible participants were selected through the inclusion and exclusion criteria. 1000 participants will be recruited for the trial. after completing an baseline reseach by a online questionnaire, patients will be randomly assigned to receive a targeted short article on hcv weekly or a general health article with no mention of hcv. the intervention will last three months and a follow-up will be conduct at three month after the last intervention. outcomes: the primary outcome is antiviral therapy. the secondary outcomes are cognition and attitude towards hepatitis c, factors influencing antiviral therapy, time to first treatment and the compliance of treatment.


Eligibility criteria:
inclusion criteria: * permanent residents in the province * ages 18-69 (inclusive) * both blood anti-hcv test and hcv-rna test is positive * familiar with the use of mobile phones and wechat * informed consent and voluntary participation in the study exclusion criteria: * temporary staff who come to the city to work, travel or visit relatives, or those who will be living in other cities for a long time * suffering from other serious diseases * patients with mental disorder or memory disorder * pregnant women or those who have a plan to prepare for pregnancy within one year * refuse to participate in the investigation
the effects of staggered dosing on interactions between paired combinations of nelfinavir, ritonavir, and saquinavir

Conditions: HIV Infections

Summary: the purpose of this study is to see if staggering doses of nelfinavir, ritonavir, and saquinavir has any effect on the interactions between these drugs.


Eligibility criteria:
inclusion criteria patients must have: * absence of hiv-1 infection as documented by any licensed elisa test kit within 14 days prior to study entry. exclusion criteria co-existing condition: patients with the following symptoms and conditions are excluded: * any medical condition that, in the opinion of the investigator, would interfere with the patient's ability to participate in this protocol. patients with the following prior conditions and symptoms are excluded: * history of chronic illness such as hypertension, coronary artery disease, arthritis, diabetes, or any chronic gastrointestinal conditions that might interfere with drug absorption.

Keywords: drug interactions drug therapy, combination saquinavir hiv protease inhibitors ritonavir nelfinavir
sleep apnoea syndrome and hepatocellular carcinoma

Conditions: Sleep Apnea, Obstructive; Hepatocellular Carcinoma; Non Alcoholic Steato Hepatitis

Summary: obstructive sleep apnea (osa), one of the most frequent respiratory diseases, could represent a major worsening factor in a non alcoholic steatohepatitis and neoplastic context. our hypothesis is that osa promotes the prevalence of hcc related to nash. this national, multicenter study aims to compare the prevalence of osa in a group of patient curatively resected for nash-related hcc with a group of hcv-related hcc.

obstructive sleep apnea (osa) is a common respiratory disease characterized by the occurrence of recurrent episodes of partial or total obstruction of the upper airway called hypopneas and apneas respectively. these episodes are associated with the repetitive occurrence of the desaturation-reoxygenation sequences, the so-called chronic intermittent hypoxia (ih) which is the major stimulus underlying main cardiovascular, metabolic consequences and pro-inflammatory state found in patients with osa. recent data from cohort studies have established that osa is an even greater risk factor for cancer-related mortality. hepatocellular carcinoma (hcc) is the second cancer related death worldwide and has an increasing impact in developed countries. the epidemic of metabolic syndrome (ms) plays a growing role in the occurrence of metabolic steatohepatitis (nash) related hcc. concerning transition from nash to nash-related hcc, neither the frequency nor the underlying mechanism are known. very recently, a link between osa (ih) and nash has been highlighted. osa and intermittent hypoxia should be a major worsening factor in a neoplastic context. our hypothesis is that osa promotes the prevalence of hcc in a context of nash. the objective is to compare the prevalence of osa between patients with nash-related and hepatitis c virus (hcv)-related hcc. in this type 3, cross-sectional, multicenter, national, non-randomized study patients suffering from a nash-related or hcv-related hepatocellular carcinoma will be recruited. investigators expect to show a higher prevalence of osa in patients with hcc nash-related but also a shorter overall survival. complementary ex vivo studies on tumor samples will be conducted in order to explore the mechanisms by which osa and ih would promote carcinogenesis

Eligibility criteria:
inclusion criteria: * man and woman * \>18 years * diagnosis of nash-induced hcc or hcv-induced hcc * patients treated by surgical excision * patients not opposed to the study exclusion criteria: * patient refusal * alcohol consumption\> 20g / day for women and\> 30g / day for men * patient with hcv genotype 3 * tumor vascular invasion identified preoperatively * other etiologies of hepatopathies (alcoholic, viral b, autoimmune, hemochromatosis) * other chronic respiratory diseases: chronic obstructive pulmonary disease, respiratory insufficiency * patient weight variation \>5% since surgical treatment of his hcc * subject deprived of liberty or under guardianship

Keywords: sleep apnea, obstructive hepatocellular carcinoma non alcoholic steato hepatitis hepatitis c virus
study to evaluate the efficacy, safety and pharmacokinetics of asb17061 capsules in adult subjects with atopic dermatitis

Conditions: Atopic Dermatitis

Summary: the purpose of this research study is to gather scientific information about the effectiveness of the study drug, asb17061 capsules, when compared to placebo in adult subjects with atopic dermatitis.


Eligibility criteria:
inclusion criteria: * adult subjects ages 18 to 65 years * a diagnosis of atopic dermatitis (ad) * an investigator's global assessment (iga) score of 2 or higher and ad affecting at least 5% of total body surface area (bsa) * other than active ad, in good health with no medical condition that may jeopardize the safety of the subject or impact the validity of the study results * subjects must be practicing acceptable birth control methods exclusion criteria: * taking systemic immunosuppressive therapy within 3 months prior to screening or systemic (cortico) steroid therapy within 4 weeks prior to screening * use of phototherapy or tanning beds within 6 weeks of screening * presence of a clinically significant disorder involving gastrointestinal, renal, hepatic, neurologic, hematologic, endocrine, oncologic, pulmonary, immunologic, psychiatric, or cardiovascular disease or any other condition, which will jeopardize the safety of the subject or impact the validity of the study results * female subjects who are pregnant or breastfeeding

Keywords: atopic dermatitis eczema
speed of injection and pain during routine infant vaccinations

Conditions: Routine Infant Immunizations; Pain Management

Summary: vaccine injections are a significant source of pain for infants. altering the injection speed when administering vaccines may be an effective intervention and is feasible (cost neutral). at present, there are no data regarding impact of injection speed on vaccine injection pain in infants. the aim of this study is to address this knowledge gap and to compare the impact of slow and fast vaccine injection speeds on pain during routine infant vaccinations.

to date, there has been no evidence-based guidance regarding the rate at which vaccines should be injected to minimize pain. this has led to a disparity in practice. some vaccinators favour a slow rate of injection (around 8-10 sec/ml) while others prefer a more rapid rate of injection (around 2-4 sec/ml).the slow injection method leads to a longer needle dwelling time with the increased possibility of the needle moving around and causing pain by damaging muscle tissue. rapid injection, on the other hand, may lead to a sudden distension of muscle tissue, which itself could be painful. allowing the muscle sufficient time to distend in order to accommodate the vaccine might minimize pain. this study will address the identified knowledge gap by comparing pain in infants undergoing routine vaccinations with a fast vs. slow injection speed.

Eligibility criteria:
inclusion criteria: * healthy 2 and 4 month old infants receiving their primary vaccine injections, pediaceltm (0.5ml) and prevnartm (0.5ml) (in conjunction with and preceded by oral rotarixtm vaccine) and healthy 6 month old infants receiving their routine vaccine injection, pediaceltm (0.5ml) exclusion criteria: * infants with impaired neurological development; history of seizures; administration of sedatives or narcotics in the preceding 24 hours; parental inability to use study tools; parent vaccine refusal; prior participation in the trial; and refusal to be video recorded
efficacy of new ergonomic device in non-specific neck pain.

Conditions: Neck Pain

Summary: the goal of this clinical trial is to learn if smartphone holder works to treat neck pain in adults. it will also learn about the usability of smartphone holders. the main questions it aims to answer are: * does the smartphone holder decrease pain level and improve function in case of neck pain? * how likely will the participants recommend the holder for their friends? researchers will compare adding the holder to the commonly used exercises for neck pain to a group which will receive the common exercise only. to see if the holder can modify neck pain. participants will: * do the exercise with or without using the holder * visit the clinic 3 times per week for a month for receiving exercise * keep a diary of their usage for the holder


Eligibility criteria:
inclusion criteria: * • subject's age ranges from 18-45 * having neck discomfort symptoms that were triggered by certain neck positions and by palpating the cervical musculature for at least three months * smartphones addiction \>6hours per day exclusion criteria: * • pregnancy. * neck pain associated with whiplash injuries or trauma * medical red flag history (such as tumour, fracture, metabolic diseases, rheumatoid arthritis and osteoporosis) * neck pain with cervical radiculopathy or neck pain associated with externalized cervical disc herniation. * if the patient had previous surgery in the neck area (irrespective of the reason for the operation)

Keywords: neck pain text neck smartphone ergonomics posture
effectiveness of a handwriting intervention

Conditions: Developmental Dysgraphia

Summary: the purpose of the study was to examine the effectiveness of an occupational therapy led handwriting intervention for special education and at-risk kindergarten students.

in spite of the increased use of computers and tablets by children of younger and younger ages, handwriting remains an important skill for school success and continues to be a critical skill for elementary school students to acquire. beginning writers still do most of their composing by hand, and difficulties with handwriting can have far-reaching effects on a child's self esteem and academic success. this study examined the effectiveness of an occupational therapy led handwriting intervention for special education and at-risk kindergarten students. there is a tremendous need for studies examining the outcomes of handwriting instruction provided to the at-risk population, in order to determine whether outcomes are similar to those seen in the typically developing population. there is also a need for studies that examine outcomes in "real world" settings, in addition to those settings manipulated for experimental research. such studies may not be as "clean" as those in classic experimental research, however it is imperative to examine outcomes in the settings that are occurring in today's schools. at-risk children are increasingly being provided intensive interventions under an rti model, and children receiving special education services are increasingly being integrated into less restrictive settings, thus creating classroom environments with a wide variety of students needs. the purpose of this study was to examine the outcomes of a handwriting intervention, the size matters handwriting program (smhp), provided to kindergarten children currently receiving iep or rti interventions. this study attempted to answer the following research questions: 1. will at-risk kindergarteners (those children receiving iep or rti support) participating in a 16 week, occupational therapy led handwriting smhp intervention group demonstrate significantly greater improvements in handwriting legibility than children who do not receive the intervention? 2. will at-risk kindergarteners, participating in a smhp handwriting intervention, make significantly greater gains in the pre-reading skills of letter-name recognition and letter-sound recall, than students who do not receive the intervention? the study incorporated a two group pre and post-test design. both groups consisted of kindergarten students receiving iep and/or rti support. an occupational therapist provided biweekly group handwriting instruction using the size matters handwriting program to students in the intervention group (n = 23), while the control group (n=12) received the standard handwriting instruction.

Eligibility criteria:
* inclusion criteria: * kindergartners receiving educational support in the form of iep and/or rti tier 2 interventions * must be in a support classroom where services are delivered * exclusion criteria: * children not in kindergarten * children not receiving iep or rtl tier 2 interventions
study of vtd in waldenstrom's macroglobulinemia

Conditions: Waldenstrom Macroglobulinemia; Lymphoplasmacytic Lymphoma

Summary: this study is a phase 2, single-arm, open-label, multi-institutional trial to evaluate the efficacy of combination therapy of bortezomib, thalidomide, and dexamethasone in patients with newly diagnosed waldenstrom's macroglobulinemia and lymphoplasmacytic lymphoma.


Eligibility criteria:
inclusion criteria: * age of 19 or older * newly diagnosed waldenstrom's macroglobulinemia or lymphoplasmacytic lymphoma * previously untreated with chemotherapy * ecog performance status of 2 or lesser * peripheral blood white blood cell count ≥ 3,500/ul * peripheral blood neutrophil count ≥ 1,000/ul * peripheral blood platelet count ≥ 20,000/ul * peripheral blood hemoglobin ≥ 6.0g/dl * serum total bilirubin ≤ 2.0 mg/dl * serum aspartate aminotransferase ≤ 2.5 x (upper normal limit) * serum alanine aminotransferase ≤ 2.5 x (upper normal limit) exclusion criteria: * diagnosed with other malignancy within 5 years before enrollment * prior hematopoietic stem cell transplantation * prior organ transplantation * uncontrolled central nervous system involvement * congenital immunodeficiency * acquired immune deficiency syndrome (aids) * pregnancy * uncontrolled epilepsy * uncontrolled psychological disease * peripheral neuropathy of grade 3 or higher

Keywords: waldenstrom's macroglobulinemia lymphoplasmacytic lymphoma bortezomib thalidomide
safety and efficacy study of the quickflex micro model 1258t left heart pacing lead

Conditions: Heart Failure

Summary: this is a prospective, multi-center non-randomized clinical study to evaluate the safety and efficacy of the quickflex micro model 1258t left ventricular lead in a heart failure patient population. the study will be conducted at a maximum of 20 investigational centers located in the united states and a total of 68 patients will be enrolled.

the investigational left heart lead, quickflex model 1258t, will be implanted with a legally marketed st. jude medical cardiac resynchronization therapy implantable cardioverter defibrillator (crt-d) device. patients will be followed at pre-discharge, 1-month, 3-month,and then every 6 months until the end of the study.

Eligibility criteria:
inclusion criteria: * approved indication for crt-d system exclusion criteria: * previous cerebrovascular accident (cva) or transient ischemic attack (tia) within 3 months of enrollment * previous left ventricular (lv) lead implant * have had a heart attack,unstable angina or cardiac revascularization (percutaneous transluminal coronary angioplasty (ptca),coronary artery bypass grafting (cabg), stent) within 40 days prior to enrollment

Keywords: left heart pacing lead cardiac resynchronization therapy (crt) heart failure icd
effect of low flow anesthetics on neurocognitive decline in the elderly

Conditions: Neurocognitive Disorders; Inhalation; Vapor

Summary: this study aims to investigate the effect of inhaled anesthetics with a low fresh gas flow on cognitive function of elderly patients undergoing elective surgery

geriatric patients scheduled to undergo surgery were tested with mini mental state examination (mmse) in the preoperative visit. mmse was repeated postoperatively at the 6th hour, the 1st, 3rd, and 7th day. visual analogue scale (vas) test was performed simultaneously on the postoperative 6th hour, the 1st, 3rd, and 7th day. two cohorts were created according to the amount of fresh gas flow (low flow vs high flow) in the maintenance phase of the inhalational anesthetic. mmse scores were compared between cohorts and baseline. vas scores were compared between cohorts.

Eligibility criteria:
inclusion criteria: * age\>65 * consenting to participate * scheduled for surgery longer than 2 hours under ga * able to read and write exclusion criteria: * age\<65 * refusing to participate * existing visual impairment preventing the patient from reading or writing * unable to read and write * existing major neurocognitive disorder * use of tiva or regional techniques * allergies to the volatile agents * uncontrolled dm, acute alcohol intoxication * conditions increasing tissue oxygen consumption (sepsis, thyrotoxicosis, etc.) * anticipation/existence of major hemorrhage * haemodynamic instability \> 10 min or more than 5 times intraoperatively