Kornimate/medical-research-clean huggingface dataset:
compare pharmacokinetics and safety of jp-1366 between korean and caucasian

Conditions: Anti-Ulcer Agents

Summary: to evaluate the effect of coadministration of aceclofenac, meloxicam and naproxen on pharmacokinetic interactions and safety of jp-1366 in healthy korean subjects and to compare the pharmacokinetic nature and safety of jp-1366 between healthy korean and caucasian.


Eligibility criteria:
inclusion criteria: * subject who has fully informed about this study and understand co mpletely, decide to participate voluntarily and agree with the writte n consent before screening test. * a healthy volunteer in the age of upper 19 at the time of the scree ning test. * subject whose bmi was 18.0 or more and 30.0 or less and whose b ody weight was 50kg or more if in male, and 45kg or more if in fe male at the same time. * caucasian in part 4 who has medical interview and documents(passport, birth certificate) or signatured conformation by the subject. exclusion criteria: * the subject who has clinically significant diseases with liver, kidney, nervous system, digestive system, immune system, respiratory system, and endocrine system, musculoskeletal system or the blood or tumor disease, cardiovascular disease (including orthostatic hypotension), mental disorder or with history of the disease. * the subject who has a history of gastrointestinal disorders (gastrointestinal ulcers, gastritis, gastric ulcer, gastroesophageal reflux disease, crohn's disease, etc.) or history of gastrointestinal surgery that may affect the safety and pk/pd evaluation of the investigational product (except for simple cecal surgery and hernia surgery) * the subject who has a hereditary disorder (galactose intolerance, lapp lactase deficiency, glucose-galactose malabsorption etc.). * the subject who has a history of an active peptic ulcer or bleeding. * screening laboratory test showing any of the following abnormal laboratory results: alt, ast, total bilirubin \> 2.0 x uln - e-gfr \< 60 ml/min/1.73m2 (ckd-epi formula) - positive result for serological test (hbsag, hcv ab, hiv ab, syphilis regain test)
effects of teriparatide in postmenopausal women with osteoporosis

Conditions: Postmenopausal Osteoporosis

Summary: effects of teriparatide in postmenopausal women previously treated with alendronate or raloxifene.


Eligibility criteria:
inclusion criteria: * postmenopausal women aged at least 50 years * a previous clinical diagnosis of osteoporosis * at high risk for fracture * current therapy for at least 18 months prior to study entry with either raloxifene hcl or alendronate na exclusion criteria: * history of metabolic bone disease other than osteoporosis * history of malignant neoplasm within the last 5 years except for superficial basal cell carcinoma or squamous cell carcinoma
medical and surgical treatment of esophageal reflux

Conditions: Gastroesophageal Reflux

Summary: the purpose of this project is to lay the groundwork for a proposed clinical trial to compare the effectiveness of two approaches to gastroesophageal reflux disease: treatment with medications and treatment with anti-reflux surgery. this project includes a non-interventional pilot study to test ways of measuring outcomes of treatment, and to gauge potential participants' willingness to enroll in the proposed clinical trial.


Eligibility criteria:
inclusion criteria: * age 18-80 * diagnosis of gastroesophageal reflux disease * have taken proton pump inhibitor medications exclusion criteria: * prior esophageal surgery * other serious medical conditions

Keywords: esophageal reflux
the role of lung ultrasonography score in predicting prognosis in term and late preterm newborns with postnatal respiratory distress

Conditions: Respiratory Distress Syndrome; Lung Ultrasonography Score

Summary: respiratory distress in term and late preterm infants in the first hour after birth is a prevalent condition. this situation may occur due to different reasons such as minimal respiratory stress, transient tachypnea of newborn, respiratory distress syndrome, and congenital pneumonia. it can be not easy to distinguish this in the first hours. this study aimed to investigate the place of the lung ultrasonography score in the prognosis of these patients.


Eligibility criteria:
inclusion criteria: * having symptoms of respiratory distress that begin soon after birth, * \> 34 gestational age, * \>1900 gr birth weight, * family consent exclusion criteria: * congenital anomaly * chromosomal anomaly * hydrops fetalis * congenital heart disease

Keywords: respiratory distress syndrome lung ultrasonography newborn
sensitivity diagnosing traumatic knee injuries with and without injection of blue dye into the knee joint

Conditions: Traumatic Knee Arthrotomy

Summary: the purpose of this study is to determine if adding blue dye improves the saline load test, which is a way to detect a traumatic intraarticular knee injury by injecting normal saline into the knee and looking for outflow through the wound.


Eligibility criteria:
inclusion criteria: * individuals with diagnosis warranting elective knee arthroscopy exclusion criteria: * pregnant women * decreased knee range of motion (flex \< 125, ext \<0) * active infection of knee joint * history of or current intraarticular knee malignancy * history of open traumatic injury of the knee
chinese acute ischemic stroke treatment outcome registry

Conditions: Ischemic Stroke

Summary: this is a multi-center registry study. the investigators will include 10,000 patients with confirmed acute ischemic stroke in china. the aim of the study is to survey current treatment situation in china and compare the effectiveness and safety between different intervention regimens.

stroke is a common disease in china. compared to western countries, there are many treatment regimens used in clinical practice in china. but their treatment effects are not well validated. the aim of the study is to survey current treatment situation in china and compare the effectiveness and safety between different intervention regimens.

Eligibility criteria:
inclusion criteria: 1. age ≥18 yesrs 2. confirmed diagnosis of an ischemic stroke 3. admission within 1 week after onset of stroke or within treatment time window for patients of thrombolysis treatment 4. signed informed consent exclusion criteria: 1. with intracerebral hemorrhage 2. with severe morbid (estimated survival duration less than 3 months) 3. could not provide follow-up information
melanil in the treatment of melasma

Conditions: Melasma

Summary: the purpose of the study is to assess the efficacy of melanil facial cream in the treatment of melasma. the duration of this double-blind phase 3 clinical trial will be 54 weeks. the control group will receive treatment with hydroquinone (2%). the estimated number of subjects to be recruited and randomized for the study is 150. the primary outcome measure: melasma area and severity index (masi) score will be assessed at the beginning of the study and at weeks 4, 8, 12 and 54. photographs taken at the beginning of the study and at weeks 8, 12 and 54 will be evaluated by two independent dermatologists. occurrence of adverse effects will also be assessed.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of melasma * fitzpatrick's skin types i to iv * signed informed consent * given verbal agreement on protection from uv light during treatment by the usage of physical barriers (umbrellas, caps, hats, etc). exclusion criteria: * fitzpatrick's skin types v and vi * treatment with steroids within the duration of the clinical trial. * oral contraception within the duration of the clinical trial * usage of other cosmetics within the duration of the clinical trial * treatment with clofazimine within the duration of the clinical trial

Keywords: cosmetic facial cream melasma melanil
inflammation reduction by trehalose administration

Conditions: Acute Coronary Syndrome

Summary: arterial wall inflammation has been consistently suggested to serve a causal role in promoting atherosclerosis and predisposing to hard cardiovascular outcomes. therefore, there is a global trend in the pharmaceutical industry to develop safe and effective anti-inflammatory agents that could lessen arterial wall inflammation and prevent its detrimental impact on atheroma growth and instability. to this end, autophagy has emerged as a key regulator of inflammation and dysfunctional autophagy machinery has been consistently reported as a contributing factor to atherosclerosis and inflammation. trehalose, a natural disaccharide sugar found extensively among miscellaneous organisms, by preventing protein denaturation plays various protective roles against stress conditions. numerous studies indicated trehalose's ability to induce macrophage autophagy-lysosomal biogenesis and reduce inflammation. also, intravenous (iv) administration of trehalose showed beneficial effects in the reversal of atherosclerosis in atherosclerotic animals. therefore, in this study, the investigators will explore the potential efficacy of iv trehalose administration on arterial inflammation by employing an positron emission tomography (pet) with 18f-labeled fluoro-2-deoxyglucose (18f-fdg) and computed tomography (18f-fdg pet/ct) technique which noninvasively characterizes vascular inflammation and atherosclerosis.


Eligibility criteria:
inclusion criteria: * men and women aged between 18-55 years * having a history of acute coronary syndrome * having a baseline high-sensitivity c-reactive protein (hs-crp) of ≥ 2mg/l * willingness to participate in the trials. exclusion criteria: * lactation or breastfeeding * diabetes mellitus * nephrotic syndrome or estimated glomerular filtration rate (egfr) \< 30/ml/min/1.73m2 * active or recurrent hepatic disease or/and alanine aminotransferase (alt)/aspartate aminotransferase (ast) (alt/ast) of \> 3 times upper normal limit or total bilirubin of \> 2 times upper normal limit * active infectious or febrile disease * any type of malignancy * history of transplantation * consumption of immunosuppressive drugs.

Keywords: acute coronary syndrome trehalose arterial inflammation autophagy
primipara pregnant women and motivational interview

Conditions: Pregnancy Related

Summary: the first birth is the most important moment a woman experiences in her life as she embarks on her motherhood journey. waiting for the birth of a new life can be very exciting for mothers. positive birth is an approach that asks the woman to approach her birth story from a positive perspective and to have a stronger, more impressive and positive birth experience. primipara pregnant women especially benefit from and need this positive birth approach. motivational interviews are interviews conducted to support positive births and to help women develop a positive attitude towards their birth experiences. this planned study was planned as a randomized controlled trial with pre-test and post-test measurements, with the aim of determining the level of traumatic birth perception in primipara women who were given or not given training and examining the effects of positive birth motivational education by taking into account the need for education with numerical data.


Eligibility criteria:
inclusion criteria:must be between the ages of 20-35, have a primipara pregnancy (30-34 weeks of gestation), be a turkish citizen, have no history of risky pregnancy, have no psychological disorders, and wish to participate in the study voluntarily. - exclusion criteria:having an unplanned or involuntary pregnancy, having a threat of premature birth, wanting to leave the job at any time. -

Keywords: positive birth motivational interviewing training primiparous pregnant women perception of traumatic birth
comparing rehabilitation programs for patellofemoral pain syndrome

Conditions: Patellofemoral Pain Syndrome

Summary: patellofemoral pain syndrome (pfps) is a common knee disorder affecting physically active people. despite the growing base of support for the early introduction of hip strengthening exercises into the rehabilitation of pfps, there have been few randomized clinical trials comparing isolated hip to isolated quadriceps strengthening. the purpose of this study is to determine how different exercises affect pain, strength, muscle activity, and function in female subjects with patellofemoral pain. the researchers hypothesize that females diagnosed with pfps who initially participate in a hip strengthening program will report a greater perceived level of function, greater strength, less pain, and improved neuromuscular activity than those who participate in a progressive quadriceps strengthening intervention.

methods: thirty-three females with pfps will perform either initial hip strengthening (hip group) or initial quadriceps strengthening (quad group) for 4 weeks, prior to 4 weeks of a similar program of functional weight-bearing exercises. self-reported pain, function, and functional strength were measured. isometric strength was assessed for hip abductors, external rotators, and knee extensors. a mixed-model analysis of variance will be used to determine group differences over time.

Eligibility criteria:
inclusion criteria: * anterior or retropatellar knee pain reported during at least 2 of the following activities: ascending and descending stairs, hopping and running, squatting, kneeling, and prolonged sitting * insidious onset of symptoms not related to trauma * pain with compression of the patella * pain on palpation of the patellar facets exclusion criteria: * symptoms present for less than one month * clinical evidence of other knee pathology * history of recent knee surgery within past one year * history of patellar dislocations or subluxations * current significant injury affecting other lower extremity joints

Keywords: knee pain rehabilitation
is serum ykl-40 capable of predicting intrauterine growth restriction (iugr) and preeclampsia?

Conditions: Intrauterine Growth Restriction; Preeclampsia

Summary: objective: to investigate the role of maternal serum ykl-40 and uterine artery doppler, at gestational age 12, 20, 25 and 32 weeks, and the relation to preeclampsia and intrauterine growth restriction. the serum marker ykl-40 is related to conditions involving inflammation, infection, tissue remodeling, fibrosis and cancer. iugr and preeclampsia are known to be related to inflammation and tissue remodeling. methods: women attending screening for downs syndrome is scanned with uterine artery doppler and delivered blood samples at ga 12, 20, 25 and 32 respectively. when pregnancy outcome is registered by medical records blood samples are retrieved and analyzed for serum ykl-40. serum ykl-40 are correlated to the presence of bilateral notching, preeclampsia and different degrees of intrauterine growth restriction.


Eligibility criteria:
inclusion criteria: * pregnant danish speeking women exclusion criteria: * conditions/diseases involving chronical inflammation, or immunological activity

Keywords: iugr preeclampsia ultrasound ykl-40
effect of shockwave therapy on post-laminectomy fibrosis low back pain patients.

Conditions: Post-laminectomy Syndrome

Summary: the aim of this study is clinical trial to investigate the effect of radial extracorporeal shock wave therapy in patients with sciatica and low back pain caused by post laminectomy scarring. the study will answer the following question: 1. what is the effect of shock wave therapy on low back pain and sciatica caused by post-laminectomy fibrosis? patients in the study group will receive radial extracorporeal shock wave therapy and conventional physical therapy program (tens, electric heating packs, and mckenzie back exercises).


Eligibility criteria:
inclusion criteria: 1. recruited patients will be diagnosed by neurosurgeon as sciatic pain and low back pain caused by post laminectomy scarring. 2. both genders will be recruited. 3. their age will range from: 30-50 years (sharaf, et al., 2022). 4. recruited patients will be randomly assigned in to two equal groups. 5. unilateral radicular sciatica. 6. constant back pain or aggravated by movement, 7. restricted lumbar range of motion. 8. tenderness at the site of incision. 9. duration of symptoms: three weeks to six months postoperatively exclusion criteria: 1. past history of vertebral fracture. 2. spinal cord compression. 3. vertebral tuberculosis. 4. polyneuropathy. 5. diabetic peripheral neuropathy. 6. spinal tumor. 7. recurrent disc herniation after surgery. 8. spondylolisthesis. 9. vascular diseases, e.g., peripheral vascular diseases, coronary artery bypass graft and coagulation diseases. 10. potential pregnancy.

Keywords: sciatica low back pain post-laminectomy syndrome radial shock wave therapy
effects of early statin treatment after acute myocardial infarction (ami) in japanese patients

Conditions: Myocardial Infarction

Summary: statins have been shown to prevent coronary artery disease and to preserve left ventricular function in dilated cardiomyopathy. the investigators hypothesized that the early use of statins would reduce cardiovascular events including heart failure in acute myocardial infarction patients. the purpose of this study is to determine whether early (within 96 hours after onset) use of any available statins are effective to prevent cardiovascular events including heart failure after acute myocardial infarction in japanese patients.

at least, in japanese, it was controversial if lipid-lowering therapy to the patients whose total cholesterol levels \<240 mg/dl was needed. furthermore, in general, a role for early statin therapy in patients with st-elevated ami reperfused by primary pci has not been clearly established. statins have been shown to prevent coronary artery disease and to preserve left ventricular function in dilated cardiomyopathy. the investigators hypothesized that the early use of statins would reduce cardiovascular events including heart failure in acute myocardial infarction patients. a prospective, randomized, open-label, multicenter trial is conducted in ami patients with normal total cholesterol levels (180-240 mg/dl). patients are randomly assigned to receive any available statin within 96 hours of ami onset or no statin and were followed for up to 24 months. the primary endpoint is a composite of cardiovascular death, nonfatal ami, recurrent symptomatic myocardial ischemia, congestive heart failure, and stroke.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute myocardial infarction * serum total cholesterol levels on admission ranges ≥180 mg/dl and \<240 mg/dl exclusion criteria: * age \< 18 years * time from symptom onset to admission \> 96 hours * use of lipid-lowering agents within the previous 3 months * known familial dyslipidemia * severe renal failure * known hepatic disease * signs and symptoms of severe heart failure (killip class iii or iv) * a scheduled pci or coronary artery bypass grafting (cabg) * a history of previous pci (within 6 months) or cabg (within 3 months) * the presence of malignant disease * the presence of allergy to statins.

Keywords: randomized prospective study lipid-lowering therapy with any available statins multicenter study japanese acute myocardial infarction primary percutaneous coronary intervention
bone health in youth with type 1 diabetes

Conditions: Type 1 Diabetes; Osteoporosis

Summary: this is an observational study of children and young adults ages 6-20 years with type 1 diabetes and age- and race-matched controls. the investigators will be examining blood and urine hormone levels as well as measures of bone density including dxa and high-resolution peripheral quantitiative computed tomography. the investigators will also be collecting data regarding physical activity via use of wearable accelerometers. the investigators hypothesize that youth with type 1 diabetes will have slower bone accrual and impaired bone microarchitectural integrity compared with non-diabetic controls, and that bones of individuals with type 1 diabetes will not respond as well to physical activity. the investigators hypothesize that poor bone accrual will be associated with sub-optimal glucose control as well as lower levels of insulin-like growth factor 1.


Eligibility criteria:
inclusion criteria: * age 6-20 years * out of honeymoon period (cohort with diabetes) exclusion criteria: * bmi\<5th percentile for age * bmi\>95th percentile for age * celiac disease * hyperthyroidism, uncontrolled hypothyroidism * history of significant hepatic disease, renal disease, oncologic disease, cardiovascular disease, psychiatric disease * anemia (hgb \<11) * taking medications other than insulin known to affect bone health (including hormonal contraception, glucocorticoids, growth hormone)

Keywords: type 1 diabetes osteoporosis children
a comparative study between concomitant versus load therapy in eradication of helicobacter pylori infection

Conditions: H. Pylori Infection

Summary: all patients who presented with epigastric pain and dyspeptic symptoms will undergo endoscopic gastric biopsies. the patients will be subjected to: full history taking, clinical examination, liver function tests, renal function tests, cbc, inr, abdominal ultrasonography. about 200 patients diagnosed to have h. pylori by infection by microscopically examined, endoscopic gastric biopsies will be enrolled in our study. all available formalin fixed and paraffin embedded tissue blocks of gastric endoscopic biopsies will be resectioned and stained with haematoxylin and eosin. modified giemsa stain, and alcian blue/ pas stain will be used for verification of helicobacter pylori and demonstration of intestinal metaplasia respectively. biopsies will be classified using the updated sydney system of classification of gastritis

the patients will be randomized (closed envelopes) into one of two groups: 1. patients will receive concomitant therapy comprising of pantoprazole (40 mg twice daily), amoxicillin (1 gm twice a day), clarithromycin (500 mg twice a day) and metronidazole (500 mg twice a day) for 2 weeks. 2. patients will receive load therapy comprising of levofloxacin (250 mg with breakfast), omeprazole (40 mg before breakfast), nitazoxanide (alina) (500 mg twice daily with meals) and doxycycline (100 mg at dinner) for 10 days. h. pylori eradication will be confirmed by h. pylori stool antigen testing at least 4 weeks after cessation of antibiotic therapy with stoppage of ppi therapy at least one to two weeks.

Eligibility criteria:
inclusion criteria: * all patients who presented with epigastric pain and dyspeptic symptoms exclusion criteria: 1. patients recently (within 6 months) treated with anti-h. pylori therapy. 2. allergy to any drugs used in our protocol 3. patients on ppi, antibiotics, and steroid or non-steroidal anti-inflammatory drugs within past one month before randomization. 4. concomitant significant comorbidities (advanced cardiac, renal, hepatic disease). 5. presence of gi malignancy. 6. pregnancy or lactating women. 7. unable or refuse to give consent. -
observation versus immediate surgery of low risk bladder cancer

Conditions: Bladder Cancer

Summary: this trial is a randomized, multi-center, non-inferiority study comparing observation versus immediate surgery for low grade, noninvasive bladder cancer.


Eligibility criteria:
inclusion criteria: * history of low grade, noninvasive urothelial carcinoma of the bladder with a new recurrence that meets the following criteria: * total tumor burden ≤3cm in size (multiple lesions permitted) * low grade appearance (grade 1 or grade 2) * noninvasive appearance (ta) * no history of carcinoma in situ (cis) or lesions concerning for cis * negative urine cytology (atypical or suspicious for low grade neoplasm are acceptable) exclusion criteria: * high grade and/or invasive and/or carcinoma in situ disease * concomitant upper tract urothelial carcinoma * any patient who is pregnant or who may have plans to become pregnant. * positive cytology