Kornimate/medical-research-clean huggingface dataset:
glucose variability in subclinical hypertrophy

Conditions: Diabetes Mellitus; Lipohypertrophy

Summary: evaluation of insulin absorption at sites affected by clinically apparent lipohypertrophy through short-term continuous glucose monitoring has shown inconsistent results and it is yet unknown how or if subclinical lipohypertrophy affects absorption. in this study investigators propose to enroll at least 20 people who participated in phase 1 and who were determined to have subclinical lipohypertrophy to examine the correlation between glycemic control and amount of insulin injected in subclinical hypertrophic areas using capillary blood glucose and continuous glucose monitoring.

patients will be randomized and data interpreters will be blinded to two alternating six-day protocols where the patients will be advised verbally and by written instruction to inject insulin in sites of subclinical lipohypertrophy or normal subcutaneous tissue. patients will be asked to monitor and record their capillary blood glucose with meals and prior to bedtime using their own capillary blood glucose monitor. a trained research nurse at the diabetes centre will instrument each patient with an ipro 2 glucose sensor (medtronic canada). these sensors continuously measure blood glucose for periods of up to 7 days. a trained nurse will clean the skin with a superficial disinfectant and a small catheter will be inserted in the subcutaneous tissue at a non-lipohypertrophic site. the catheter will then be attached to a glucose sensor. patients will wear this sensor for two periods of 6 days each at different sites. at the end of each of the two six day periods, the sensor will be removed.

Eligibility criteria:
inclusion criteria: * participation in phase 1 * type 1 or type 2 diabetes for at least 2 years * using insulin to manage diabetes * at least 19 years of age exclusion criteria: * taking insulin secretagogues (gliclazide, glyburide, glipizide * taking other injectable diabetes medications (i.e. liraglutide, victoza) * taking systemic steroids (e.g. prednisone) * not fluent in speaking and writing english (unless accompanied by a translator)

Keywords: ipro2 continuous blood glucose recorder subclinical
search for new genetic mutations major effect in crohn's disease

Conditions: Crohn Disease

Summary: this study highlight genetics mutations with major effect in crohn's disease (cd) by wes in individuals affected and healthy individuals from epimad inserm invs registry families.

the epimad registry covers a large area of northern france (9 millions inhabitants) and collects all incident cd cases and data from cd multiplex families (families with 3 or more cd affected patients) in the nord the pas de calais the somme and the seine maritime. if the investigators could demonstrate that most cd cases from multiplex families were related to high frequency of nod2 gene mutations, the investigators found some cd multiplex families without any nod2 gene involvement. thus in these families high prevalence of cd cases may rely on other major genetic susceptibility variant(s) that remain to be determined. this clinical research whole exome sequencing protocol, aiming to highlight genetics mutations with major effect in cd has been initiated. this study is a familial genetic study with intra-familial controls. the genetics analyses are: * ascertain of no significant nod2 mutation in the family members by sanger dna sequencing * wes (cd patients and family controls unaffected subjects) * genotyping of all mutations found, case control and segregation analyses to validate their implication in cd.

Eligibility criteria:
inclusion criteria: * crohn disease subject * epimad family with, at least, 3 crohn disease subjects exclusion criteria: * pregnant or lactating women

Keywords: genetic
supporting methods in cardiovascular diseases rehabilitation

Conditions: Cardiovascular Diseases; Coronary Artery Disease; Mood Disorders; Depressive Symptoms; Anxiety; Stress

Summary: the study evaluates how various therapeutic approaches perform in addressing depression, anxiety symptoms, and stress levels among patients in the second stage of cardiac rehabilitation. this study aims to evaluate the influence of the used therapeutic approaches on psychological outcomes and to compare the effectiveness of these therapies.

depression, anxiety, and high levels of perceived stress are increasingly common problems associated with cardiovascular disease (cvd). the relationship between anxiety-depressive disorders and the risk of cvd is confirmed by behavioral and physiological mechanisms. according to the american heart association, depression is a negative prognostic factor at all stages of treatment of cvd. the most important risks in people with cvd and anxiety-depressive disorders, as comorbidities, are an increased risk of recurrent cardiovascular events and increased mortality. however, psychological disorders in patients with cvd are still not sufficiently diagnosed and, consequently, are not adequately treated. therefore, it is necessary to look for effective methods to support cardiac rehabilitation from a psychological perspective. the first group of patients will receive relaxation-therapeutic recordings (referred to as the recording group) in addition to monitored cardiac physical training. the second group will receive virtual reality (vr) therapy (referred to as the vr group) alongside monitored cardiac physical training. the third group (referred to as the control group) will receive schultz autogenic training as a standard supplement to cardiological training. the aims of the study: 1. the evaluation of the influence of relaxation-therapeutic recordings on the anxiety-depressive symptoms and the stress level of the patients undergoing second stage of cardiac rehabilitation. 2. the comparison of the effectiveness of therapeutic recordings with the effectiveness of vr therapy and schultz autogenic training.

Eligibility criteria:
inclusion criteria: * coronary artery disease; * the second stage of cardiac rehabilitation conducted in outpatient settings exclusion criteria: * inability to self-complete the research questionnaires; * presence of the following issues at the time of the examination or in the medical data: disturbances of consciousness, psychotic symptoms or other serious psychiatric disorders; * initiation of psychiatric treatment during the research project; * contraindications for virtual therapy (epilepsy, vertigo, eyesight impairment); * the patient's refusal at any stage of the research project.

Keywords: cardiac rehabilitation psychotherapy therapeutic recordings virtual reality depression anxiety stress
mild therapeutic hypothermia for patients with acute coronary syndrome and cardiac arrest treated with pci

Conditions: Cardiac Arrest; Acute Coronary Syndrome

Summary: mild therapeutic hypothermia for patients with acute coronary syndrome and cardiac arrest treated with percutaneous coronary intervention (unicorn) study is designed to determine whether mild therapeutic hypothermia (mth) applied in patients with acute coronary syndromes (acs) and cardiac arrest treated with percutaneous coronary intervention (pci) is associated with better clinical outcomes as compared with therapy without mth.

the unicorn study is a multi-center, international, observational, phase iv clinical trial which is aimed to investigate whether mth applied in patients with acs and cardiac arrest treated with pci is associated with better clinical outcomes as compared with therapy without mth. this trial will provide important information regarding the impact of mth in unconscious with a score of ≤8 on the glasgow coma scale on admission to the hospital after out-of-hospital cardiac arrest (ohca) with diagnosed or presumed acs and shockable initial rhythm.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * survivor of ohca * sustained return of spontaneous circulation (rosc) for more than 20 minutes after resuscitation * unconsciousness with a score of ≤8 on the glasgow coma scale after rosc * shockable initial rhythm * diagnosis or suspicion of acs exclusion criteria: * unwitnessed ohca * obvious or suspected pregnancy * known serious infection/sepsis before ohca * known bleeding diathesis * confirmed or suspected internal bleeding * confirmed or suspected acute stroke * confirmed or suspected cerebral injury * known serious neurological dysfunction (cpc≤4) before ohca * known serious disease making 180 days of survival unlikely * hemodynamic instability with systolic blood pressure \<65 mmhg despite treatment * time delay from rosc to mth induction \> 240 min. * asystole or pulseless electrical activity (pea) as the initial rhythm * initial body temperature \<30°c
genetic influences between cognitive function and bmi

Conditions: Obesity

Summary: in this study the investigators will interrogate an existing data set to examine whether genetic variants contribute to an inverse association between weight status and cognitive function. investigators hypothesize that body mass index (bmi) will be inversely related to a number of variables measuring cognitive function, and that that this inverse relation will be at least partially attributable to genetic variants which influence both bmi and cognition.

investigators will use existing data collected as part of the texas twin project (ttp). ttp collected neuropsychological task data on cognition (executive functioning and general cognitive abilities) from a computerized test battery, as well as bmi data, on a sample of 869 twins. investigators will use information from the known extent of genetic and environmental sharing between members of mz (monozygotic; identical) and dz (dizygotic; fraternal) twin pairs to quantify the genetic correlation between measures of cognition and bmi using biometric genetic modeling under the assumptions of the classical twin model. the specific aims are: * to examine the association between bmi and executive functioning (ef) in a sample of 869 twin children, ages 7 to 15 years old, who participated in the texas twin project (ttp) * to gauge the specificity of ef-bmi relations relative to academic achievement and general cognitive abilities. * to examine the relative contribution of genetic and environment influences to the inverse association between bmi and ef

Eligibility criteria:
inclusion criteria: all participants in the ttp database with executive functioning and bmi data, without a parent-reported medical disorder affecting growth exclusion criteria: parent-reported medical disorder affecting growth more than one sibling in the dataset (if triplets are present, only two randomly selecting siblings will be included).

Keywords: obesity bmi executive functioning general cognitive ability twin study heritability cognition gcta
university of pennsylvania weight loss study

Conditions: Weight Loss

Summary: this is a 4-arm, randomized controlled trial to evaluate the effectiveness of financial incentives to motivate and sustain long-term weight loss. the study will recruit eligible employees at a large health management company to participate in a 6-month weight loss program and have weight measurements for an additional 3-month follow-up period. the primary outcome measure in this randomized controlled trial will be pounds of weight lost. the experimental groups will include variations of deposit contracts (participants put their own money at risk, and lose that money if they fail to achieve their weight loss goal) and fixed payments. the use of deposit contracts is a powerful mechanism for inducing behavior change that is based on loss aversion, a psychological concept first described by nobel prize winner daniel kahneman and amos tversky in 1979. a deposit contract takes advantage of the fact that people typically feel the pain of a loss more than the pleasure of a gain, increasing ones motivation to reach a goal. the study hypotheses are 1) mean weight loss will be greater in all intervention groups compared to the control group by the end of 24 weeks; and 2) individuals in the intervention groups will have a lower mean weight at the end of the 3-month follow-up period than individuals in the control group.


Eligibility criteria:
inclusion criteria: * aged 18 to 70 (inclusive) * bmi between 30 and 50 (inclusive) exclusion criteria: * inability to consent * no known illiteracy and/or inability to speak, read, and write english * participation in another weight loss program * participation in another research study * current treatment for drug or alcohol use * consumption of 5 alcoholic drinks per day * myocardial infarction or stroke within the past 6 months * uncontrolled hypertension (defined as bp170 mm hg systolic or bp110 mm hg diastolic) * current addiction to prescription medicines or street drugs * serious psychiatric diagnoses (severe depression, schizophrenia) * pregnancy * diabetic and using any medicine besides metformin to control blood sugars * metastatic cancer * unstable medical conditions that would likely prevent the subject from completing the study * previous diagnosis of an eating disorder * history of unsafe weight loss behaviors such as binging or the use of laxatives

Keywords: weight loss motivation contracts
the cognitive neural mechanisms and neuroregulatory interventions of realistic creative problem-solving under the effects of drug addiction

Conditions: Drug Addiction

Summary: drug addiction persists as a significant global social concern with a negative impact on social harmony and stability that cannot be ignored. after returning to society, individuals with drug addiction often suffer from impaired creative problem-solving abilities and difficulties in interpersonal cooperation. the difficulties in survival stress and the sense of helplessness triggered by these factors are important reasons that lead them to seek drugs repeatedly and even to commit criminal behaviors. therefore, enhancing creative realistic problem-solving abilities emerges as a pivotal pathway for drug addicts to facilitate rehabilitation from drug addiction and achieve societal adaptation. the project emphasizes both individual and collaborative creative solution generation for realistic problem solving. the abnormal cognitive neural mechanisms and interpersonal neural mechanisms will be systematically explored by using multiple cognitive and neuroimaging methods, such as functional near-infrared spectroscopy (fnirs), electroencephalography (eeg), and eye-tracking. from the cognitive-behavioral-brain level, a comprehensive neurophysiological multimodal predictive model of how drug addiction affects creative realistic problem-solving will be constructed by multi-level data fitting modeling. building upon this research foundation, the investigators will further implement single and repeated sessions of transcranial direct current stimulation (tdcs) targeting damaged brain regions for the intervention of individual and collaborative problem-solving ability under the effect of drug addiction. the indicators of brain, cognition, and behavior will be tracked at multiple time points.


Eligibility criteria:
inclusion criteria: * age between 30 and 60 years; * fulfilling the diagnostic criteria for severe substance use disorder as specified in the fifth edition of the diagnostic and statistical manual of mental disorders. * a history of heroin use exceeding ten years, with a daily average intake of at least 0.1 grams. * abstinence duration of eight months or less, with a positive result of a urine test before entering the rehabilitation center. * no history of neuromodulation treatments such as tdcs within the past six months. exclusion criteria: * a history of alcohol dependence, neurological disorders, or other complex psychiatric conditions. * the presence of intracranial metallic implants or elevated intracranial pressure. * a history of epilepsy or recent electroencephalogram evidence of epileptiform activity. * the use of implanted electronic devices, such as pacemakers;. * scalp hyperalgesia or a tendency toward bleeding. * severe cardiac conditions.

Keywords: heroin creative problem solving divergent thinking group problem solving
viability imaging in volumetric angiography (viva 1)

Conditions: Myocardial Scarring

Summary: the primary objective of this study is twofold: 1. to define inter-reader variability of myocardial viability imaging within the first pass and delayed enhancement cardiac ct perfusion imaging 2. to evaluate de ct image quality using a consensus dect protocol

the presence of myocardial scar using radionuclide or magnetic resonance imaging techniques indicates myocardial segments with a reduced likelihood of functional recovery following myocardial revascularization. preliminary evidence suggests that multi-detector ct (mdct) angiography also can detect irreversible myocardial scarring through the detection of regions of delayed hyperenhancement (de) of the myocardium.1-4 however, existing studies have been performed in single centers, and the reproducibility, and impact of this modality on recovery of myocardial function is unknown. in this study, the investigators propose a single-center trial using a standardized mdct de protocol among patients scheduled for clinical cardiac ct with planned reoperative surgical. the primary endpoint will be characteristics of de imaging of the myocardium including its inter-reader variability and factors associated with image quality. these findings will further our understanding of the role of de mdct for the detection of myocardial viability.

Eligibility criteria:
inclusion criteria: * eligible patients will be adults, ages 18 and above with: 1. known cad with prior mi based upon clinical history or electrocardiographic criteria 2. planned redo-surgical myocardial revascularization 3. referred for ct (and eligible) for pre-op substernal mapping/coronary artery evaluation exclusion criteria: 1. inability to provide informed consent 2. allergy to iodinated contrast media (unless pre-medicated with medical prophylaxis) 3. chronic kidney disease manifested by a serum creatinine \>1.5 mg/dl, an estimated creatinine clearance \<50 ml/kg/min or on dialysis 4. currently reporting or evaluated in nyha class iv heart failure

Keywords: inter-reader variability of myocardial viability imaging
randomized comparison of ultrasound versus radiofrequency denervation in patients with therapy resistant hypertension

Conditions: Therapy Resistant Hypertension

Summary: prospective, randomized trial to assess the effectiveness of different renal sympathetic denervation methods (radiofrequency main vs. branches + main vs. ultrasound based) in a cohort of patients with therapy refractory arterial hypertension and large renal arteries

the aim of this trial is a prospective, randomized comparison of three different techniques for catheter based renal sympathetic denervation. patients with larger (\>5.5 mm) renal arteries are randomized to a treatment with a radiofrequency based catheter of the main renal artery, the main renal artery, its side-branches and accessories or an ultrasound-based denervation of the main renal artery only. the primary endpoint is the change in daytime blood pressure acquired in ambulatory blood pressure measurement at 3 months.

Eligibility criteria:
inclusion criteria: * patients with resistant hypertension (≥3 antihypertensive drugs including at least one diuretic, without any dosage change in the preceding 4 weeks) and a systolic office blood pressure of \>160 mmhg, ≥1 main renal artery diameter \>5.5 mm exclusion criteria: * pregnancy, known renal artery stenosis, average systolic daytime rr \<135 mmhg in 24h ambulatory blood pressure measurement (abpm), ≥1 renal artery diameter \<4.0 mm, life-expectancy \<6 months, participation in any other clinical trial.
move for surgery (mfs): evaluating the use of wearable technology for preconditioning before thoracic surgery

Conditions: Preconditioning; Lung Cancer, Nonsmall Cell

Summary: wearable technology is increasingly being used to promote healthy behaviour. in this study, the investigators propose the development and evaluation of move for surgery, which utilizes a wearable activity bracelet (fitbit) and proven behavioural change techniques, for preconditioning of patients prior to lung cancer surgery. the primary outcome of this study will be compliance with move for surgery, as a surrogate measure for feasibility. secondary outcomes, including accrual rates, perioperative pulmonary complications, cost per patient, and patient satisfaction, will also be collected. the investigators have partnered with the canadian partnership against cancer (cpac) and lung cancer canada (lcc) to develop move for surgery. the ultimate goal of this preliminary study is to lay the groundwork for a subsequent comparative trial to evaluate the impact of move for surgery on postoperative complications in the thoracic surgery population.


Eligibility criteria:
inclusion criteria: * eligible participants include patients with nsclc set to undergo pulmonary resection. exclusion criteria: * there will be no exclusion based on functional status in this feasibility study; rather, a subsequent analysis of participant demographics will be performed to inform future phases of this study.