Kornimate/medical-research-clean huggingface dataset:
the role of after-school exercise services in promoting myopia and physical and mental health in children

Conditions: Common Diseases; Joint Prevention; Students; After-school Extended Sports Service

Summary: this project is a prospective cohort study to evaluate the impact of after-school extended physical education services on the visual health, physical health indicators, and mental health of children and adolescents participating in these services over a one-year period. the study collected data on the participation rate, duration, activity content, and organisational form of the after-school extended hours service through a questionnaire; the demographic characteristics, sleeping habits, and dietary habits of the participants through a self-administered questionnaire on the multidisease behaviour of children and adolescents; the intensity of the activities of the students who participated in the after-school extended hours service was investigated through an accelerometer and a physical activity questionnaire; and data on students\&#39; visual acuity, body mass index, and mental health status were collected through a medical check-up. students' visual acuity data, body mass index, maximum oxygen uptake, and other indicators of physical health and mental health were collected through physical examination, and data on changes in one year were collected through half-yearly/follow-up visits to establish a cohort to evaluate the effects of after-school extended hours services on students' myopia rates, physical health and mental health levels by different types, intensity and duration of exercise.

students in grades 1-6 of several primary schools were selected as the study subjects. according to the baseline survey, the study subjects were divided into after-school extended physical education service group and non-after-school extended physical education service group, and their behavioural habits as well as the contents of the after-school extended physical education service, visual acuity, bmi, cardiorespiratory fitness, spinal curvature abnormality, and mental health were investigated by means of questionnaires and other tools, so as to analyse the relationship between after-school extended physical education service and the physical and mental health of the students.

Eligibility criteria:
inclusion criteria: * ① those who voluntarily participate in the after-school extended hours service; * those who voluntarily participate in this study and sign the informed consent; ③ basic reading, writing and comprehension skills to understand the questionnaire and be able to answer it; exclusion criteria: * ① unfit to participate in sports activities for health or physical reasons; ② suffering from glaucoma, glaucoma and other diseases. * those who suffer from glaucoma, strabismus, refractive error and other eye diseases that affect vision;

Keywords: common diseases joint prevention after-school extended sports service
national multicentric observatory of low bowel preparations in patients with ibd

Conditions: Patient With an Indication of Colonoscopy for Inflammatory Bowel Disease

Summary: national multicentric observatory of low bowel preparations in patients with ibd

prospective french multicentre observational study, during one month: from march 6th to april 6th 2017, under the auspice of the ibd group of the société française d'endoscopie digestive- sfed. all french gastroenterologists in charge of ibd patients in public or private endoscopy centers were reached out through various professional and scientific associations to participate in the study via e-mail, web sites, and national congresses. investigators were asked to prescribe the bowel preparation independently from the study, as per their usual habits. the achievement of low residue diet, the split and the timing of the preparation were left free to the investigator according to local protocols. data recording the physicians participating in the study completed data on an online questionnaire via an internet-based tool (cleanweb software, hosted by besançon university hospital research center) or through a questionnaire sheet. the questionnaire included a medical record and a self-reported patient questionnaire. the medical record included physicians and centers characteristics, patient's demographics, disease characteristics, modality of bowel preparation (diet, split dose, type of bowel preparation, delay before colonoscopy), and colonoscopy findings and outcomes. patients self-administered questionnaires assessed preparation tolerability by symptoms and satisfaction recording. clinical endpoints the efficacy of the preparation was evaluated by the boston's score (efficacy was defined as a boston's score was ≥ 7 without any segment \<2)23, the rate of caecal or anastomosis intubation and the necessity or not to repeat the colonoscopy. the tolerance was evaluated by the quantity of preparation actually absorbed by the patient, (quantity of active preparation and quantity of clear liquid), patients and investigators visual analogue scale evaluation of tolerance (vas), a self-administered validated bowel-preparation tolerability questionnaire 24 and by the patients' wish to take the same preparation for the next colonoscopy. safety data: adverse events were collected per preparation and per endoscopic procedure, at 24 hours and 30 days later. a special focus was made on aphtoid lesions as they were previously reported as adverse preparation-induced mucosal lesions possibly associated with some solutions.

Eligibility criteria:
inclusion criteria: * patient aged 18-75 years, * symptoms of ibd for at least 3 month, * inidcation of colonoscopy independent from the study. exclusion criteria: * congestive heart failure, * severe renal failure, * gastro intestinal symptomatic obstruction or occlusive bowel stenosis (a non-occlusive stenosis was not an exclusion criterion), * severe acute colitis, * severe dehydration or electrolyte disturbances, * patient's refusal to participate in the study.

Keywords: inflammatory bowel disease colonoscopy bowel preparations
characterization of sympathetic nerve activity in stress cardiomyopathy

Conditions: Cardiomyopathy

Summary: stress (takotsubo) cardiomyopathy (sc) is a peculiar form of acute, reversible myocardial dysfunction predominantly affecting the apical and mid left ventricular segments. in this institution over the last two to three years the investigators have identified more than a dozen patients with stress cardiomyopathy. the investigators' overarching goal is to characterize these individuals with the hope of identifying risk factors and developing strategies to prevent the occurrence of sc in situations where the likelihood in susceptible individuals may be high.

stress (takotsubo) cardiomyopathy (sc) is a peculiar form of acute, reversible myocardial dysfunction predominantly affecting the apical and mid left ventricular segments. this was originally described in japan but is increasingly recognized all over the world especially in older women. there is evidence to support that excess sympathetic activation and catecholamine surges are potential mechanisms that cause this temporary myocardial 'stunning'. the amount of catecholamines in circulation of patients with sc was 2 to 3-fold higher when compared to subjects with acute myocardial infarction related equivalent cardiac dysfunction \[wittstein, et al. nejm, 2005\]. in this institution over the last two to three years the investigators have identified more than a dozen patients with stress cardiomyopathy. this diagnosis has been confirmed by echocardiographic documentation of normalization of left ventricular function over a course of few days to weeks. the investigators' overarching goal is to further characterize these individuals with the hope of identifying risk factors and developing strategies to prevent the occurrence of sc in situations where the likelihood in susceptible individuals may be high.

Eligibility criteria:
inclusion criteria: * diagnosis of stress cardiomyopathy in the past exclusion criteria: * coronary artery disease (cad), primary coronary intervention (pci) or coronary artery bypass graft (cabg) * cardiac dysfunction * heart failure * significant arrhythmias * severe chronic obstructive pulmonary disease (copd) * diabetic neuropathy * pregnancy

Keywords: stress-induced cardiomyopathy takotsubo cardiomyopathy
a study evaluating the safety, tolerability, pharmacokinetics, and immunogenicity of intravitreal injections of ro7303359 in participants with geographic atrophy secondary to age-related macular degeneration

Conditions: Geographic Atrophy

Summary: this multicenter study will investigate the safety, tolerability, pharmacokinetics, and immunogenicity of ro7303359 following single intravitreal (itv) injection in participants with geographic atrophy (ga) secondary to age-related macular degeneration (amd). participants will receive an itv injection of ro7303359 in the single ascending dose stage and the maximum tolerated dose (mtd) or maximum tested dose (mted) of ro7303359 in the expansion stage.


Eligibility criteria:
ocular inclusion criteria study eye: * visual acuity: bcva letter score of 19-48 etdrs letters (snellen equivalent of 20/125-20/400) using etdrs charts at a starting distance of 4 meters * well-demarcated area of ga secondary to amd in the absence of choroidal neovascularization (cnv) * ga area must be \>/= 0.5 disc area (1.25 mm\^2) ocular exclusion criteria, study eye: * ga in the study eye due to causes other than amd * history of vitrectomy surgery, submacular surgery, or other surgical intervention for amd * previous laser photocoagulation for cnv, diabetic macular edema, retinal vein occlusion, or proliferative diabetic retinopathy * prior treatment with photodynamic therapy, external beam radiation therapy (for intraocular conditions), or transpupillary thermotherapy ocular exclusion criteria, both eyes: * evidence of prior or active cnv * previous participation in interventional clinical trials for ga or dry amd, except for vitamins and minerals, irrespective of the route of administration (i.e. ocular or systemic) within the last 6 months
to assess totum-854 on blood pressure in subjects with moderately elevated blood pressure

Conditions: Elevated Blood Pressure

Summary: the main objective of the study will be to compare the efficacy of a 2.65 g/day dose of totum-854 versus placebo in decreasing sbp in subjects with high-normal blood pressure and grade i hypertension following 12 weeks of daily intake.


Eligibility criteria:
main inclusion criteria: * office systolic blood pressure between 130 and 159 mmhg and diastolic blood pressure \< 100 mmhg * body mass index (bmi) between 18.5 and 35 kg/m² * weight stable within ± 5 % in the last three months * no significant change in food habits or in physical activity in the 3 months prior to randomization and agreeing to keep them unchanged throughout the study main exclusion criteria: * known or suspected secondary hypertension * known hypertensive retinopathy and/or hypertensive encephalopathy; * history of spontaneous or drug-induced angioedema; * clinically significant valvular heart disease or severe aortic stenosis * history of acute coronary syndrome (non-st elevation myocardial infarction, st elevation myocardial infarction, and unstable angina pectoris), stroke, or transient ischemic attack within 6 months prior to screening * suffering from a severe chronic disease or gastrointestinal disorders found to be inconsistent with the conduct of the study by the investigator

Keywords: dietary supplement plant extracts
interventions for enhancing adherence to syphilis treatment and follow-up: study protocol for the health information and monitoring of sexually transmitted infections (sim) randomized controlled trial

Conditions: Syphilis

Summary: the sim study is a single-centre, randomized, controlled trial with a 12-month follow-up period. the aim is to determine which of the 3 methods of follow-up is the most effective in promoting patient treatment compliance. the recruitment of participants will be done by invitation, and tests will be performed in a mobile unit in locations accessible to large populations. the goal is to perform 10,000 quick tests, with results confirmed by venereal disease research laboratory (vdrl) tests. patients with a confirmed diagnosis according to vdrl test results will be randomized in one of three monitoring arms: follow-up by telephone, follow-up via a game in a smartphone app, or conventional follow-up by a health professional. all analyses will follow the intention-to-treat principle.


Eligibility criteria:
inclusion criteria: * all adults aged 18 years and older with sorologic test positive for syphilis exclusion criteria: * participants who did not return after three contact attempts will be excluded from the study, * pregnant women * participants who are not able to provide contact information * participants who are illiterate * participants those who underwent syphilis treatment within the previous three months.

Keywords: prevalence incidence men who have sex with men protocol
monotherapy versus placebo over 10 days in integrase naive hiv-1 infected adults

Conditions: Infection, Human Immunodeficiency Virus; HIV-1 Infection

Summary: to investigate safety, tolerability and anti-viral activity in integrase-naïve hiv-1 infected adults


Eligibility criteria:
inclusion criteria: * documented hiv-1 infection with screening viral load between 5000 and 300,000 copies/ml. * baseline cd4 cell count greater than 100. * females must be of non-childbearing potential * not have received antiretroviral therapy in the 12 weeks prior to first dose. exclusion criteria: * must not be infected with hepatitis b or c. * patients must not have any acute laboratory abnormality. * must not have any active cdc (centers for disease control and prevention)category c disease (1993), except cutaneous kaposi's sarcoma not requiring systemic therapy during the trial.

Keywords: gsk364735 hiv-1 integrase inhibitor
covid-19 vaccines and the development of new luts

Conditions: COVID-19 Vaccine Adverse Reaction; Lower Urinary Tract Symptoms

Summary: this study was conducted to check whether coronavirus disease 2019 (covid) vaccines have a relationship with luts or not in a healthy and mostly medically free population.


Eligibility criteria:
inclusion criteria: 1. medical student 2. having had a covid-19 vaccine exclusion criteria: none

Keywords: covid-19 vaccines luts medical students
a low-fat diet combined with moderate-intensity aerobic exercise versus low-fat diet, aerobic exercise alone on dyslipidemia and depression status in obese patients

Conditions: Dyslipidemias

Summary: it was defined that exercise and dietary interventions are used to control dyslipidemia and depression in obese individuals, whilst rare investigations have examined the concurrent effects of a low-fat diet and moderate-intensity aerobic exercise training (miaet) on dyslipidemia and depression in obese patients. hence, we assessed the potential influences of a low-fat diet combined with miaet on blood lipids and depression in those individuals.


Eligibility criteria:
inclusion criteria: * age of 30-50 years * clinical diagnosis with obesity (bmi˃30) * mild to moderate depression * impaired blood lipids * no use of medications last 6-12 months * no smoking exclusion criteria: * neuromuscular, endocrinal, musculoskeletal, cardiovascular disorders * severe depression * patients using medications of dyslipidemia, depression, or obesity last 6-12 months.
impact of hepatitis b virus genotype on treatment response in children with chronic hepatitis b

Conditions: Chronic Hepatitis b

Summary: the study aimed to evaluate the relationship between hepatitis b virus genotype and treatment response in children with chronic hepatitis b with specific treatment indications. this is a prospective cohort study, with a follow-up period of at least 12 months, conducted at children's hospital 1 and city children's hospital, ho chi minh city, vietnam. the patient's blood was taken to be tested for hepatitis b virus genotyping using sanger sequencing at the center for molecular biomedicine ho chi minh city. the research hypothesis is that genotype is related to treatment response.


Eligibility criteria:
inclusion criteria: * children from 2 years old to under 16 years old are diagnosed with hepatitis b chronic disease and * hbsag or hbv dna: positive for at least six months and * liver enzyme alt: continuously increased by\> 70 for male and \> 50 for female (\> 2 x uln) and * the virus is proliferating: hbv dna above 20,000 iu/ml (if hbeag positive) or hbv dna above 2,000 iu/ml (if hbeag negative) and * a parent or legal guardian of the pediatric patient obtains consent for them to participate in research. exclusion criteria: * hiv and hepatitis c co-infection * patients have other chronic liver disease (wilson, autoimmune hepatitis) * patients are being treated with immunosuppressive drugs * psychomotor retardation, cerebral palsy, brain sequelae

Keywords: hepatitis b treatment response genotype children
ketoprofen topical patch 20% in the treatment of pain associated with shoulder, elbow or knee tendonitis or bursitis

Conditions: Tendonitis; Bursitis

Summary: the purpose of this study is to evaluate the effect of a ketoprofen topical patch on the pain associated with tendonitis or bursitis of the shoulder, elbow or knee.

this randomized, double-blind, placebo-controlled, parallel group study will be conducted in patients with tendonitis or bursitis of the shoulder, elbow or knee. eligible patients will have tendonitis or bursitis or the shoulder, elbow or knee and will be randomized (in a 1:1 ratio) to receive double-blind treatment with either the ktp or a matching placebo patch to be applied once daily for 21 days. patients will return to the clinic for assessments on day 3, day 7, day 14 and day 21; a follow-up assessment will be conducted by telephone on day 35. at each visit through day 21, patients will rate their average pain intensity during daily activities and while at rest using the 11-point scale (range 0 to 10), and will rate their functional disability. patients will also complete an electronic diary in which pain intensity and pain relief ratings will be recorded three times daily. ratings of the quality of sleep will be recorded in the diary each morning, and the use of study treatment and rescue medication will be recorded in the diary each day. ibuprofen will be provided as prn rescue medication.

Eligibility criteria:
inclusion * males or females 18 years of age or older * diagnosis of tendonitis or bursitis of the shoulder, elbow or knee * meet pain entry criteria * willing to discontinue use of any pain medication not provided by the study exclusion: * have tendonitis or bursitis secondary to a systemic inflammatory disease, calcification or requiring surgery * have received corticosteroids in the 30 days preceding screening * have a history or physical examination finding that is incompatible with safe participation in the study * have a history or physical examination finding that is incompatible with study product use * are taking medications or other substances contraindicated due to the nature of the study medication or the potential for drug interactions. * are taking medications that may significantly affect renal function

Keywords: tendonitis bursitis pain shoulder pain elbow pain knee pain tendon injury muscle, bone and cartilage disorders
identification of high risk people for colorectal cancer and evaluation of a specific surveillance system

Conditions: Cancer Colorectal

Summary: colorectal cancer is one the most frequent cancer in developed countries. in france, it rank third with 43000 new cases in 2015. french health authority recommended colonoscopy screening for people with a high risk for colorectal cancer. but this compliance with colonoscopy is low (20-40%), it is therefore necessary to develop new strategies to improve compliance. the purpose of this project is to to offer and evaluate the feasibility and the effectiveness of a specific surveillance system for high risk people for colorectal cancer the project will be divided into 2 phases: objectives of the first phase: * identify high risk people for colorectal cancer in the department of indre-et-loire, * fill in as completely as possible their colonoscopic history in the past 5 years, * estimate the proportion of high risk people for colorectal cancer in the target population for colorectal cancer screening in indre-et-loire (men and women aged from 50 to 74 years). objective of the second phase: compare the performed colonoscopy rate of high risk people for colorectal cancer without notion of colonoscopy in the past 58 months following or not (control group) the sending of a letter reminding the importance of compliance with colonoscopy.


Eligibility criteria:
inclusion criteria: * residing in indre et loire (france) * with increased risk for colorectal cancer * who did not perform a colonoscopy in the past 58 months exclusion criteria: - none

Keywords: high risk surveillance screening colonoscopy
clinical study of the efficacy and safety of bcd-178 and perjeta® as neoadjuvant therapy of her2-positive breast cancer

Conditions: Breast Cancer

Summary: the goal of this study is to compare the efficacy and safety of bcd-178 and perjeta as neoadjuvant therapy for her2-positive breast cancer. subjects with histologically confirmed diagnosis of her2-positive invasive breast cancer (stage ii-iii, tumor size \> 2 cm), with no estrogen (er) and progesterone (pr) receptors will be randomized to one of two treatment groups (bcd-178 group or perjeta group) in a 1:1 ratio.


Eligibility criteria:
inclusion criteria: * signed informed consent ; * histologically confirmed diagnosis of invasive breast cancer; * disease stage ct2-ct4, cn0-cn3, cm0; * positive her2 expression, negative estrogen and progesterone receptor expression; * ecog score 0-1; * adequate organ function; * baseline lvef ≥ 55%, as measured with the standard procedure; * consent of women of childbearing potential to use highly effective methods of contraception, starting from the signing of the informed consent form, throughout the study and for 6 months after receiving the last dose of the product. exclusion criteria: * stage iv (metastatic) breast cancer; * a history of any systemic therapy for breast cancer; * concomitant diseases and/or conditions that significantly increase the risk of adverse events during the study; * pregnancy or breastfeeding, as well as pregnancy planning throughout the study and for 6 months after receiving the last dose of the product; * hypersensitivity or allergy to any of the components of bcd-178, perjeta, trastuzumab, carboplatin, and docetaxel.