Kornimate/medical-research-clean huggingface dataset:
drainage amount for removal of thoracostomy tube

Conditions: Pneumothorax; Pleural Effusion

Summary: the purpose of this study is to determine whether chest tubes can be safely removed without considering how much fluid is draining through the tube.

thoracostomy tubes are routinely used to drain the pleural space of fluid and gas to optimize pulmonary mechanics. clinicians frequently postpone removal of thoracostomy tubes if the drainage from the tube exceeds a specific volume threshold for the prior 24 hours. however, there is substantial variability in the drainage volume threshold that different clinicians use, and no threshold has been established as clearly superior to any other. removing tubes independently of the drainage volume may result in a greater risk of pleural effusion or pneumothorax requiring an invasive drainage procedure. however, removing tubes independently of the drainage volume might also expedite recovery by allowing earlier removal of the tube, thus diminishing pain and increasing patient mobility. thoracostomy tube management practices, including the drainage volume threshold used, may be dissimilar for different types of disease processes, so this study will be restricted to patients who required a thoracostomy tube for treatment of traumatic injury.

Eligibility criteria:
inclusion criteria: * thoracostomy tube in place for \<72 hours * age at least 14 years * hospitalized for traumatic injury or elective operation exclusion criteria: * thoracostomy tube already removed from the pleural cavity of interest * mediastinal tubes * death expected within 48 hours * prisoner status * severe congestive heart failure * end-stage liver disease * end-stage renal disease * history of or suspected empyema involving the pleural cavity of interest * history of or anticipated need for pleurodesis of the pleural cavity of interest * malignant pleural effusion * pregnancy * previous participation in this study * thoracostomy tube drainage already \<2 ml/kg

Keywords: chest tubes trauma
effects of breathing exercises in women with chronic pelvic pain

Conditions: Chronic Pelvic Pain Syndrome; Pelvic Floor; Relaxation; Breathing Exercises; Women

Summary: the primary cause of the complex interaction of chronic pelvic pain originates from the visceral organs in the pelvic cavity, and it has been observed that musculoskeletal dysfunctions (such as increased muscle activity in the pelvic floor muscles) are often accompanied by visceral painful stimuli in the pelvic region as a result of shared innervation and visceral-somatic convergence. this study aims to investigate the effect of breathing exercises combined with pelvic floor exercises on pain, pelvic floor muscle activity, psychological factors, and quality of life in women with chronic pelvic pain.


Eligibility criteria:
inclusion criteria: * be diagnosed with chronic pelvic pain (cpa) * having pelvic pain for at least 6 months * 18-45 years old * having high resting activity of the pelvic floor (\>2 microvolts based on superficial emg (semg) readings) exclusion criteria: * having a history of pelvic cancer and/or surgery * receiving radiotherapy and/or chemotherapy * having a neurological and/or psychiatric pathology * have a urinary tract infection * menopause * presence of current pregnancy status * history of miscarriage and ectopic pregnancy * presence of prolapse * being \>30 kg/cm2 according to body mass index (bmi) * have received treatment for the pelvic area including manual therapy and electrotherapy in the last 6 months * having had botulinum toxin injections in the pelvic region in the last 6 months * having a communication problem

Keywords: women with chronic pelvic pain breathing exercises pelvic floor exercises
a non-interventional registry for patients with hepatitis b virus infection

Conditions: Hepatitis B Virus Infection

Summary: in order to tackle the unmet needs in chronic hbv infection, a consortium of clinical partners has gathered to establish a registry for patients with hepatitis b mono- and co-infections. the partners will build up a european-wide registry to be able to stratify patients for upcoming clinical trials. extensive analyses of virus and host-specific parameters are to be carried out from these patients. the knowledge gained thereby should contribute to a better understanding of the hbv control and enable patient stratification with regard to immunomodulatory therapies. furthermore, hepatitis b patients are to be identified who are willing to participate in future studies to investigate immunotherapies to cure hbv infections (e.g. therapeutic vaccines).


Eligibility criteria:
inclusion criteria: * hepatitis b virus infection thervacb sub-cohort: * confirmed chronic hepatitis b virus infection: hbsag positive for at least 1 year prior inclusion * hbeag status documented for at least 6 months exclusion criteria: thervacb sub-cohort: * age \>70 years * co-infection with hiv, hcv (rna positive), * clinically relevant concomitant liver diseases (ald, nash, haemochromatosis, autoimmune hepatitis, at1, wilson's disease, primary biliary cirrhosis etc.) * significant comorbidities (e.g. malignancies) * immunosuppressive treatment (\> 40 mg cortisol- equivalent) * liver cirrhosis (judged clinically or based on ultrasound/transient elastography) * history of hepatocellular carcinoma
the value of a convolutional neural network-based renal artery perfusion model in predicting renal function after partial nephrectomy: a prospective study

Conditions: Renal Cell Cancer

Summary: the goal of this observational study is to develop a cnn-based machine module to predict postoperative fractional renal function in people who are proposed to undergo partial nephrectomy. the main question it aims to answer is: • does this machine learning model accurately predict renal function after partial nephrectomy?

this prospective study is conducted to predict postoperative fractional renal function using the perfusion deficit method from a preoperatively established renal arterial perfusion model for people who are proposed to undergo partial nephrectomy. in this study, this prediction method will be compared with the true missing values of renal units on nuclear renal function, egfr, and cta. this study aims to evaluate the feasibility of applying the cnn-based model in predicting postoperative renal function after partial nephrectomy and provide high-level clinical evidence for the preoperative integrated diagnostic and treatment process of renal tumors, especially in terms of the functional evaluation.

Eligibility criteria:
inclusion criteria: * people with stage ct1 renal tumors confirmed by preoperative ct or mr * people who are proposed to undergoing partial nephrectomy * localized renal tumors without lymph node and distant metastases as defined by nccn guidelines * ecog score of 0 or 1 * life expectancy greater than 10 years exclusion criteria: * people with surgically unresectable lesions * people with abnormal preoperative renal function, egfr(estimated by ckd-epi)\<90ml/min/1.73m2 * people who receive preoperative molecular targeted therapy, immunotherapy, chemotherapy * people with any contraindications to surgery * people who convert to radical nephrectomy during surgery * people who receive molecular targeted therapy, immunotherapy or chemotherapy during the postoperative follow-up period * people with serious systemic disease

Keywords: articicial intelligence convolutional neural network renal arterial perfusion model partial nephrectomy fractional renal function
repurposing fenofibrate in modulating mtor/nlrp3 inflammasome in patients with ulcerative colitis

Conditions: Inflammatory Bowel Diseases

Summary: fibrates, specific pharmacological agonists of pparα, have been widely used to treat hypercholesterolemia and hypertriglyceridemia. apart from their metabolic action, anti-inflammatory properties of fibrates have been described, including inhibition of nf-kappa b signaling and pro-inflammatory cytokine production. 4 fenofibrate, an important peroxisome proliferator-activated receptor-a (ppar- α) agonist, is widely used in clinical as a triglyceride (tg)-lowering agent


Eligibility criteria:
inclusion criteria: age ≥ 18 years both male and female will be included negative pregnancy test and effective contraception. mild and moderate uc patients diagnosed and confirmed by endoscope exclusion criteria: breast feeding significant liver and kidney function abnormalities colorectal cancer patients other inflammatory bowel diseases (cd). patients with severe uc patients taking rectal or systemic steroids patients taking immunosuppressives or biological therapies addiction to alcohol and/or drugs known allergy to the fenofibrate
chemical and mechanical angioplasty for vasospasm (savebrain)

Conditions: Aneurysmal Subarachnoid Hemorrhage; Vasospasm, Intracranial; Stenosis; Ruptured Cerebral Aneurysm; Arteriovenous Malformations, Cerebral; Arteriovenous Fistula

Summary: this is a monocentric randomized prospective trial comparing 2 different endovascular strategies of intracranial arterial angioplasty in case of refractory intracranial arterial vasospastic stenosis : * chemical angioplasty * chemical and mechanical angioplasty

compare in a randomized prospective trial 2 approved treatments of refractory intracranial arterial vasospastic stenosis, chemical angioplasty versus chemical and mechanical angioplasty, using devices already used in clinical practice and ce marked: chemical angioplasty using nimotop versus chemical and mechanical angioplasty with balloon or adjustable remodeling mesh on brain perfusion evaluated by brain computed tomography (ct) perfusion nowadays, the choice between chemical or chemical and mechanical angioplasty depends on the neurointerventionist for each procedure, no difference in efficiency or safety has been proved and no solid scientific data helps the physician in choosing the correct treatment for each patient.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years. 2. non-traumatic intracranial hemorrhage (ruptured aneurysm, avm, or per-procedural complication etc) 3. ruptured aneurysm, avm, intracranial arterial perforation or any bleeding lesion secured with surgical clipping or endovascular intervention. 4. no contra-indication to both ctp and mri imaging 5. subject or legal representative is able and willing to give informed consent. 6. refractory of intracranial arterial vasospastic stenosis requiring an endovascular angioplasty with a severe stenosis defined on cta or dsa; and/or a significant hypoperfusion defined according to the mismatch profile in stroke or a mtt\>6 seconds. the volume of critically hypoperfused tissue will be based on a time to maximum of the tissue residue function (tmax) threshold of \>6 sec using the rapid (or equivalent) software. exclusion criteria: 1. angioplasty by one of the two methods considered as impossible or too risky by the neurointerventionist 2. inability to obtain consent from patient or patients relatives 3. pregnant women 4. less than 18 years of age 5. need to use any other device 6. vertebro-basilar arteries will not be randomized because of the difficulty to assess the perfusion volume in this territory, but will be treated if necessary according to our local protocol.
effects of rhythmic auditory cueing augments cognitive treadmill walking training in individuals with chronic stroke

Conditions: Stroke

Summary: the first objective of this study is to examine the superiority of the combined rhythmic auditory cueing with cognitive treadmill training (combined group) in people with stroke as compared with the cognitive treadmill walking training (cognitive group) or treadmill walking training alone (treadmill group) (aim 1). the study's second aim is to investigate the factors affecting the improvement in community walking capacity after interventions and to explore whether changes in community walking capacity are associated with changes in participation after interventions (aim 2).

a single-blind, randomized controlled trial is conducted at medical centers. ninety stroke patients will be randomized to one of the three groups. all groups will receive interventions 30 minutes per time, 3 times a week, for 4 weeks. the combined group will undertake progressive treadmill walking speed while performing a cognitive task with rhythmic auditory cueing (i.e., 110% of baseline cadence). the cognitive group will receive cognitive training while walking at a progressive speed on the treadmill. the treadmill-alone group will train only in treadmill walking with progressive speed adjusted weekly. a blinded assessor will administer three assessments. all participants will be examined for gait and cognitive performance under single-task (walking only, stroop task only) and dual-task conditions (walking while performing the stroop task) at baseline, post-intervention, and one-month follow-up. the primary outcome measures are gait and cognition under single- and dual-task conditions. the secondary outcome measures are the 6-minute walk test, mini-bestest, stroke impact scale, and walking ability questionnaire.

Eligibility criteria:
inclusion criteria: * diagnosed with first-time stroke; * more than 6 months after stroke onset; * able to walk 10 meters; * no severe vision, hearing, or speech impairments; * understand and follow the instructions and sign the informed consent form; * older than 20 years old. exclusion criteria: * orthopedic problems affecting walking or other diseases that may interfere with study participation; * a score of less than 24 on the mini-mental state examination (mmse); * severe balance disorder with a total score of less than 45 points berg balance scale.

Keywords: stroke gait rehabilitation rhythmic auditory cueing cognitive training treadmill
a study to evaluate endoscope-assisted, minimally-invasive cortical access system for chronic subdural evacuation

Conditions: Chronic Subdural Hematoma

Summary: the purpose of this study is to evaluate a less-invasive alternative to the currently available method of removing aging blood in the subdural space.


Eligibility criteria:
inclusion criteria: * must be 55 years of age or greater. * have a clinically symptomatic chronic subdural hematoma greater than 1 cm in maximal thickness and be judged clinically to need subdural evacuation. exclusion criteria: * failure to obtain consent. * vulnerable study population. * any need for chronic anticoagulation. * pregnancy (verified by pregnancy testing at screening or medical history of a hysterectomy, oophorectomy, or post-menopausal).prior surgery for subdural hematoma. * glasgow coma scale (gcs) less than 8.
pharmacodynamics study of mrx34, microrna liposomal injection in melanoma patients with biopsy accessible lesions

Conditions: Melanoma

Summary: this study is designed to investigate the biomarkers, pharmacodynamics and pharmacokinetics of the liposomal micro-ribonucleic acid-34 (microrna-34, mir-34). melanoma patients with easily accessible lesions will undergo serial biopsies and serial blood samples will be collected.

mrx34 induction therapy consists of 3 cycles of mrx34 treatment given over an approximately 8 week period. dexamethasone 10 mg po (or iv) will be given as premedication. on days 1-5 of each treatment cycle, mrx34 will be given as a daily infusion followed by 16 days of rest. at screening a tumor biopsy sample will be required from all patients. additional biopsies will be collected at cycle 1 day 3 and the end of cycles 1 and 3 (day 18 +/- 1 day)

Eligibility criteria:
inclusion criteria: * ≥18 years of age * advanced or metastatic cutaneous, acral or mucosal melanoma * tumor lesions accessible to serial biopsies * ecog ≤ 1 * anc ≥, plts ≥100,000 /mm3 exclusion criteria: * serious active non-malignant disease * central nervous system metastasis

Keywords: biosy accessible melanoma
clinical studies of kikuchi's disease

Conditions: Lymphadenitis

Summary: kikuchi-fujimoto disease is a distinctive syndrome of necrotizing lymphadenitis which was formally described in 1972 by two japanese pathologists, kikuchi and fujimoto. it is a benign, self-limited disease that predominantly occurs in young women. it was more common in asian people, especially in japanese. the most frequent clinical presentations are fever (30\~50%) and cervical lymphadenopathy, often tender in palpable. other lymph node regions can be affected, and hepatosplenomegaly may be present. the laboratory findings include leucopenia with atypical lymphocytosis. esr, transaminases and lactate dehydrogenase are often raised. the clinical features are easily confused with other conditions, particularly lymphoma. therefore the diagnosis depends on the pathological findings. the typical findings are paracortical lesions consisting of patchy zones of eosinophilic fibrinoid necrosis and abundant karyorrhexis. in general, spontaneous resolution of symptoms and signs within a few months can be expected without treatment.for decades, the etiology of kikuchi's disease has been speculated. although the perforin and fas pathways of cytotoxic t cells induce an abundance of apoptosis and thus induce necrotizing lesions, the trigger factor is unknown. since the disease can precede or occur in association with a connective tissue disorder, especially sle, the autoimmune contribution to the etiology has also been speculated. however, the clinical course of kikuchi's disease, often sudden onset and spontaneous resolution, the frequent flu-like or upper respiratory prodrome, and the prominence of cervical lymphadenopathy, support a viral cause. evidence for a viral cause also includes peripheral blood atypical lymphocytosis and elevated serum ifn-a or 2'-5' oligoadenylate synthetase levels. several infectious agents have been suggested, including bacteria (e.g. brucella, yersinia), parasites (e.g. toxoplasmosis) and viruses (e.g. ebv, cmv, hhv6, hhv8, parvovirus b19, htlv, hiv).the aim of this study is to collect cases of kikuchi' disease in bureau of nhi and ntuh. we will analyze the incidence rate, age of onset, sex, season of onset and clinical course to see if there is any clustered cases, or nosocomial infection. then we will study the etiology of kikuchi's disease especially the infection causes by analyzing pathologic specimen and serology. we hope to find out the etiology of kikuchi's disease and the new treatment.


Eligibility criteria:
inclusion criteria: * kikuchi's disease
denovo nt longitudinal data collection (ldc) knee study

Conditions: Degenerative Lesion of Articular Cartilage of Knee; Osteochondritis Dissecans

Summary: the purpose of this study is to evaluate the long-term outcomes of denovo nt, a tissue product used for the repair of cartilage damage in the knee. this product has been on the market since 2007 and implanted in more than 10,000 patients around the country.

knee cartilage injury is a major cause of pain and functional impairment in young to middle age adults, and can lead to progressive joint degeneration. adult cartilage has little regenerative capacity and many of the current treatment options have limited or unknown durability. denovo nt is an allogeneic tissue graft, prepared from donated juvenile cartilage, which has been shown to have a higher chondrogenic potential than adult cartilage. the graft involves a single surgery with no need for scaffolds, flaps or donor-site morbidity. this study will follow the long-term outcomes and durability of denovo nt in patients grafted with this product in the knee, for up to five years. it will enroll subjects prospectively (at the time of surgery) and retrospectively (those who have been previously implanted). data will be collected on patient-reported outcomes, results of knee examinations, and reoperations and revisions.

Eligibility criteria:
inclusion criteria: * has a contained articular cartilage lesion(s) of the knee or osteochondritis dissecans ocd lesion(s) of the knee for which arthroscopic or surgical intervention is warranted, or has had prior treatment with denovo nt for a contained articulare cartilage lesion(so of the knee or osteochondritis dissecans ocd lesion(s) of the knee * has voluntarily signed the irb approved informed consent * is of stable health and is able to undergo surgery * is male or female over the age of 18 years * is physically and mentally willing and able to comply with post-operative rehabilitation and routinely scheduled clinical visits exclusion criteria: * displays a high surgical risk as determined by the investigative surgeon * is pregnant or breast-feeding * has a clinically diagnosed autoimmune disease * has an active joint infection or history of chronic joint infection at the surgical site * has damage to the subchondral bone that has not/will not be repaired prior to denovo nt treatment

Keywords: cartilage repair articular cartilage defects
partner navigation intervention for hepatitis c treatment among young people who inject drugs

Conditions: Hepatitis C

Summary: the partner navigation intervention study is a randomized controlled study (rct) to assess the efficacy and mechanism of action of the first behavioral intervention to increase hepatitis c (hcv) treatment initiation among adult people who inject drugs (pwid).

after an initial ramp-up phase to ensure intervention materials and protocols meet the needs of the target population and organizational setting, we will apply a stratified randomized design to enroll 250 adult pwid with recently diagnosed hcv infection ("index") and their primary injecting partner("partner") into a randomized control efficacy trial of a two-session partner navigation intervention, compared to standard of care. the primary endpoint is starting hcv treatment. recruitment will over sample pwid between 18-30 years of age.

Eligibility criteria:
inclusion criteria: * self report injecting drugs in the past month * self report a primary injecting partner (currently inject drugs together) * hcv infection identified at partnering community-based clinical site

Keywords: young people who inject drugs