Kornimate/medical-research-clean huggingface dataset:
evaluation of the cryotherapy in the prevention of nails toxicity induced by taxotere® in breast or prostate cancer

Conditions: Breast Neoplasms; Prostate Cancer; Nail Diseases

Summary: taxotere® can induce nails changes like dyschromia, hematoma, lines of beau-reil (signing the stop of the epithelial proliferation), abscess, or pain. in this context, this randomized, monocentric phase iii trial evaluates the cryotherapy, using frozen glove, in the prevention of nails toxicity induced by taxotere® in patient treated for breast or prostate cancer. primary objective: demonstrate a reduction of the nails toxicity using frozen glove during chemotherapy with taxotere®. secondary objectives: analysis of time of protection against onycholysis estimation of the efficiency of cryotherapy, and impact on quality of life tolerance and compliance of the frozen glove


Eligibility criteria:
inclusion criteria: * patients with hormono-resistant breast cancer or metastatic prostate cancer treated by chemotherapy with taxotere®. * patients aged 18 and older * nail toxicity \< grade 2 (ctc-ae version 3.0) * informed patients with signed consent exclusion criteria: * history of treatment with taxane * raynaud syndrome * distal metastasis in superior extremity * nail diseases * distal arteriopathy * cold intolerance * peripheral neuropathy\>=2 * pregnancy, breast feeding * unable to give informed consent * unable to have a medical follow-up for social, geographical, family or psychological reasons

Keywords: neoplasm breast neoplasm docetaxel glove
international headache registry study

Conditions: Headache Disorders, Primary; Headache Disorders, Secondary; Migraine; Tension-Type Headache; Vertigo; Vestibular Migraine; Fibromyalgia

Summary: in the international headache and vertigo registration study, patients aged 4-99 years with headache (primary headache and secondary headache such as migraine and tension type headache), vertigo (vertigo diseases such as vestibular migraine) and chronic pain (fibromyalgia and other diseases) were collected. the biomarkers, imaging features, right-to-left shunt of the heart (lung), genetic characteristics, treatment, and outcome (in relation to other diseases) of headache-related diseases were studied, and long-term follow-up was planned.

1. research contents: in the international headache and vertigo registration study, patients aged 4-99 years with headache (primary headache and secondary headache such as migraine and tension type headache), vertigo (vertigo diseases such as vestibular migraine) and chronic pain (fibromyalgia and other diseases) were collected. the biomarkers, imaging features, right-to-left shunt of the heart (lung), genetic characteristics, treatment, and outcome (in relation to other diseases) of headache-related diseases were studied, and long-term follow-up was planned. 2. research target: we study biomarkers, imaging features, right-to-left shunt of heart (lung), genetic features, real-world treatment studies, and outcomes (in relation to other diseases) for headache and vertigo related diseases.

Eligibility criteria:
inclusion criteria: the following are requirements for entry into the study: 1. written informed consent and participant privacy information (eg, written authorization for use and release of health and research study information) obtained from the participant prior to initiation of any study-specific procedures. 2. male or female participants ages 4 to 99 years, inclusive, at visit 1. 3. headache patients meeting the diagnostic criteria for ichd-3, including primary headaches such as migraine and tension tension-type headaches, secondary headaches, and patients who meet the headache diagnosis in the ichd-3 appendix (including vestibular migraine). exclusion criteria: 1. patients who were unable to complete scales such as headache diary. 2. patients denied or unable to be admitted for long-term follow-up.

Keywords: migraine headache disorders vertigo vestibular migraine fibromyalgia
the relationship between cervical radiculopathy and eye-hand coordination

Conditions: Cervical Radiculopathy

Summary: this study will be conducted to investigate if there is a relationship between cervical radiculopathy and eye-hand coordination.

cervical radiculopathy is a disorder involving dysfunction of the cervical nerve roots commonly secondary to cervical spine degenerative changes such as disk herniation and/or foraminal stenosis compressing the nerve roots. clinical manifestations are pain in neck and one or both of the upper extremities, as a result of compression or irritation of nerve roots in the cervical spine. it can be accompanied by motor, sensory, or reflex deficits. it is most common in persons 45-60 years of age, which result in terrible chronic pain. eye hand coordination is the ability to do activities which require the simultaneous use of hands and eyes. it is a complex cognitive skill which unites visual and motor skills in the person and allowing the hands to guide by the visual stimulations. it lies at the core of our daily activities and interactions with objects and people around us as to be a defining characteristic of typical human life. previous studies show that there was a marked alteration in the hand function in subjects with the cervical radiating pain. since there was no study which investigated the relationship between cervical radiculopathy and eye hand coordination despite it is an important skill that adults use in countless activities of daily living and during working.

Eligibility criteria:
inclusion criteria: * subjects normal with no neck complain. * patients of cervical radiculopathy due to cervical discogenic lesion. * ages range from 30-50 both males and females. * subjects should be able to follow simple verbal commands or instructions included in the procedures. exclusion criteria: * participants with any neck trauma. * cervical post-operative patients. * participants with vision deficiency. * participants with perceptual and cognitive problems with score less than 24 in mini mental state scale (appendix i) (goudsmit et al., 2018). * participants with any other neurological or musculoskeletal problems. * participants take medications that affect their attention. * participants have space-occupying lesions eg. tumors

Keywords: eye hand co ordination cervical radiculopathy
effect of intensive dietary intervention in children with birth weight between 1500 and 2000 g

Conditions: Perinatal Disorders of Growth and Development

Summary: there are few scientific reports on preterm infants with birth weights between 1500 and 2000g. adequate and properly balanced supply of nutrients believed to better growth and cognitive development in this patient group, and optimized nutrition is an important part of treatment there is a need for more studies that can provide knowledge of growth and weight development in preterm and small for gestational age (sga) infants with a birth weight between 1500 and 2000g.

there has been little focus, at least there are few scientific reports on preterm infants with birth weights between 1500 and 2000g, at least in norway. studies have shown the benefit of enhanced protein and energy supplements in very low birth weight infants (vlbw, birth weight \< 1500g), regarding growth and neurodevelopment . adequate and properly balanced supply of nutrients is believed to give better growth and cognitive development in premature infants with slightly higher birth weight, i.e between 1500 and 2000g (1). in an intervention study of vlbw children at four norwegian hospitals we found lower supply of energy and protein than international recommendations (2). a larger proportion of premature children were stunted growth (weight below 10 percentile for age) during hospitalization. although this applies to preterm infants with birth weight less than 1500 g, this may also be the case for larger premature patients. more studies that can provide knowledge of growth rate, weight and neurodevelopmental outcomes in preterm and small for gestational age (sga) infants are warranted. this study examines those with birth weight between 1500 and 2000g. overall, this may provide new and useful knowledge that can help to optimize the nutrition to preterm and sga infants with a this range of birth weights

Eligibility criteria:
inclusion criteria: 1. birth weight between 1500 and 2000g. 2. no invasive catheters or ventilator (wish homogeneous group). 3. no malformations or chromosomal disorders. 4. parents give informed written consent 5. born at study hospitals exclusion criteria: 1. birth weight below 1500 and above 2000g. 2. invasive catheters or ventilator. 3. malformations or chromosomal disorders.
serial movement assessment in collegiate athletes who perform injury prevention training

Conditions: Injury Leg; Injury, Knee; Injury;Sports; Injury, Ankle

Summary: athletic injury can result in decreased athletic performance or removal from sport participation. there may also be psychological and financial impacts of athletic injury. additionally, there can be long-term consequences, such as increased risk of subsequent injury or arthritis. therefore, determining ways to prevent athletic injury from occurring is critical. movement quality during sport is related to injury risk. athletes who move poorly are generally at increased risk of injury compared to athletes who move well. movement quality can be improved through exercise-based injury prevention training, thereby decreasing injury risk. this purposed of this study is to evaluate movement quality multiple times over the course of an athletic season in collegiate athletes who perform injury prevention training. the hypothesis is that movement quality will improve over the course of an athletic season.

neuromuscular control, or quality of movement, during sport is related to injury risk. athletes who move poorly are generally at increased risk of injury compared to athletes who move well. neuromuscular control can be improved through exercise-based injury prevention training (called preventive training programs, or ptps), thereby decreasing injury risk. neuromuscular control is dynamic and therefore should be evaluated regularly; however, no study has serially evaluated neuromuscular control in athletes who perform ptps. the overall objective of the proposed study is to longitudinally evaluate multiple aspects of neuromuscular control (i.e., movement quality, balance) across several time points during a single athletic season in collegiate athletes who perform ptps. therefore, two specific aims are proposed: specific aim 1: evaluate neuromuscular control at multiple time points during an athletic season in collegiate athletes who perform ptps. specific aim 2: evaluate multiple measures of neuromuscular control over the course of an athletic season in collegiate athletes who perform ptps. a field-based, experimental, cohort study will be used to address both specific aims. subjects will be recruited from ncaa-division iii men's and women's soccer, volleyball and basketball teams. neuromuscular control will be assessed four times during the athletic season using the landing error scoring system (less), the balance error scoring system (bess), and the star excursion balance test (sebt). the less evaluates movement quality, while the bess and the sebt evaluate static and dynamic balance, respectively. subjects will perform ptps for about 10 minutes/day, at least 4 days/week.

Eligibility criteria:
inclusion criteria: * national collegiate athletics association (ncaa) division iii athlete * coach and athletic trainer elect to receive injury prevention services * ages 18-24 exclusion criteria: -does not participate on ncaa division iii athletic team

Keywords: sport injury injury prevention neuromuscular control
the effect of covered eye walking on electroencephalogram in stroke patients compared with open eye walking

Conditions: Stroke

Summary: post-stroke walking abnormalities present significant rehabilitation challenges. visual deprivation training has been shown to be more effective than open-eye training. the investigators intend to examine the changes in electroencephalography patterns in stroke patients during visually deprived walking tasks. the stroke participants will be fitted with a brain cap. the participants will walk with their eyes open for 60 seconds, and then their eyes will be blindfolded as they continue walking for another 60 seconds. electroencephalography will monitor the signals in real-time during both walks.

the electroencephalography data collection will be conducted in the rehabilitation department of geriatric hospital affiliated with nanjing medical university. upon commencing the experiment, participants will walk at a comfortable pace with their eyes open for a duration of 60 seconds. following this initial test, a rest period of five minutes will be provided. for the visual deprivation walking trial, participants will be instructed to keep their eyes open throughout the trial. investigators will apply an adequately sized blindfold to ensure complete visual deprivation, and the participants will proceed to walk for 60 seconds. during both trials, one investigator will remain one step behind the participant at all times to ensure safety.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of stroke * disease duration of more than 14 days * ability to walk at least 10 m without assistance, exclusion criteria: * visual impairment * severe cognitive impairment

Keywords: electroencephalography walking visual deprivation
immune and viral outcomes of hiv-1 therapy interruption

Conditions: HIV Infections

Summary: the purpose of this study is to determine if stopping anti-hiv drugs for a period of time is safe and effective for enhancing the immune function of patients with hiv.

our preliminary studies have shown that structured treatment interruption of highly active antiretroviral therapy (haart) may boost patients' immune responses to hiv-1. in this study, we will test the hypothesis that repeated structured treatment interruptions will increase hiv-1 immunity and result in better control of viral replication than in controls. we will test this hypothesis by determining time to viral rebound after withdrawal of antiretroviral therapy in a randomized, non-blinded study of a well-characterized subject population from a single center. patients in this study will be randomized to either treatment interruption or control groups. patients will be monitored for adherence to therapy and changes in immune status following haart interruption. cd4 percentage, cd 4 and cd8 mediated anti-hiv-1 responses, cell surface t-cell antigen expression, and thymic function will be assessed.

Eligibility criteria:
inclusion criteria * hiv-1 positive * hiv rna \< 500 copies/ml on a regimen of two nucleoside reverse transcriptase inhibitors (nrtis) and either one protease inhibitor (pi) or one nonnucleoside reverse transcriptase inhibitor (nnrti) for 6 months prior to study entry - hiv rna \< 50 copies/ml at study screening * cd4 \> 400 cells/mm3 with cd4 nadir of \> 100 cells/mm3 * agree to medication event monitoring system monitoring of one component of antiretroviral regimen * hiv-1 viral load \>10,000 copies/ml at any time prior to initiating the current uninterrupted haart regimen * willing to abstain from all immunomodulatory drugs during the study

Keywords: chronic hiv infection treatment interruption hiv-specific immune response immune response virological response treatment experienced
coronary flow and myocardial viability: the flovita study

Conditions: Myocardial Infarction; Myocardial Ischemia

Summary: evaluation of fractional flow reserve (ffr) is a key method for assessing ischemia with a view to guiding revascularization strategy following acute coronary syndrome. a stenosis that appears to be severe by angiography may cause limited ischemia (with an ffr value \>0.80) due to the incapacity of the necrotic zone to achieve physiological hyperemia, i.e. maximal coronary flow. recently, it has been demonstrated that absolute coronary flow, and micro- and macrovascular resistance, as measured by a thermodilution technique, using the rayflow microcatheter (hexacath) are strongly associated with myocardial mass. in extensive necrosis, there is a loss of myocardial mass, and these tools could be of potential interest in measuring myocardial viability, which reflects the extent of remaining viable myocardial mass. therefore, this study aims to investigate the relationship between both absolute coronary flow and microvascular resistance, and myocardial viability assessed by mri. in a prospective, single-centre, interventional study, we will compare absolute coronary flow and microvascular resistance in the left anterior descending artery, in patients with and without a history of st segment elevation mi.


Eligibility criteria:
inclusion criteria: * inclusion criteria for the stemi group: * st segment elevation mi ≥7 days treated by angioplasty of the left anterior descending (lad) artery * scheduled to undergo angiography for fractional flow reserve (ffr) assessment of a lesion other than the infarct-related artery. * inclusion criteria for the control group: * patients undergoing non-urgent coronary angiography for stable angina or silent ischemia * with measure of the ffr on one or more vessels (intermediate lesion \<90% without proven ischemia) * absence of any significant lesion on the lad (as assessed by angiography or ffr\>0.8) * inclusion criteria for both groups: * written informed consent * affiliation to a social security regimen (or beneficiary thereof). exclusion criteria: * target vessel (lad) not permeable. * ffr \<0.8 in the lad * coronary spasm * left ventricular ejection fraction \<0.50 or a history of anterior mi in patients in the control group * hypertrophic cardiomyopathy * severe valvular heart disease * history of coronary artery bypass graft * patients with limited legal capacity or patients under guardianship/tutorship * patients with anticipated poor compliance as assessed by the investigator * patients not affiliated to any social security regime. * pregnant women. * subjects within the exclusion period of another clinical trial as noted in the national registry of research volunteers

Keywords: microvascular resistance fractional flow reserve myocardial viability
bismuth improves the efficacy of levofloxacin-containing triple therapy for helicobacter pylori treatment

Conditions: Functional Dyspepsia; Peptic Ulcer

Summary: to examine and compare the efficacy of 2 week levofloxacin-containing therapies with and without bismuth for h.pylori treatment.

the success rate of the standard triple therapy for h. pylori infection is decreasing recently.fluoroquinolone has been proposed to replace clarithromycin as an alternative in the treatment. however prevalence of h.pylori resistance to levofloxacin has increased rapidly in our area. the purpose of this study is to observe the efficacy of 14 day levofloxacin triple therapy-based, bismuth-containing quadruple therapy for h.pylori treatment.

Eligibility criteria:
inclusion criteria: * patients who presented with upper gastrointestinal symptoms and endoscopically proven h.pylori-positive functional dyspepsia and scarred peptic ulcer exclusion criteria: * patients with peptic ulcer, previous h.pylori eradication therapy, previous gastric surgery, pregnancy, lactation, major systemic diseases, receipt of anti-secretory therapy, antibiotics or bismuth in the preceding 4 weeks, or allergy to any one of the medications

Keywords: eradication helicobacter pylori bismuth
tack optimized balloon angioplasty (toba) study

Conditions: Peripheral Vascular Disease

Summary: a multi-center, post-ce mark study designed to evaluate the performance of the intact vascular tack-it endovascular stapler™ in subjects with vascular flaps (e.g.; post-angioplasty dissection) resulting from percutaneous transluminal balloon angioplasty (pta) of superficial femoral or popliteal artery(ies).

intact vascular intends to conduct a prospective, single arm, multi-center, post-ce mark study designed to evaluate the performance of the intact vascular tack-it endovascular stapler™ in subjects with vascular flaps (e.g.; post-angioplasty dissection) resulting from percutaneous transluminal balloon angioplasty (pta) of superficial femoral or popliteal artery(ies).

Eligibility criteria:
inclusion criteria: * rutherford clinical category 2, 3 or 4 * abi less than or equal to 0.90 * reference vessel diameter is between 2.5mm and 5.5mm * target lesion has stenosis greater than or equal to 70% or is occluded * target lesion is less than or equal to 10cm in length exclusion criteria: * previously implanted stent in the ipsilateral superficial femoral or popliteal artery * target treatment area is severly calcified (e.g. circumferential calcification or calcium plaque visible on plain fluoroscopy that extends far more than 5.0cm continuously)
the impact of covid-19 outbreak on trans-population's health in italy

Conditions: Transgender Persons; Coronavirus; Coronavirus Infection; COVID; COVID-19

Summary: during the covid-19 outbreak, it was necessary to remodel the healthcare offer for all categories of subjects in order to minimize unnecessary movements of people while maintaining an adequate level of assistance. this is also true for transgender people, who are periodically requested to come into the clinic for hormonal therapy monitoring and continuation. in our center telemedicine programs dedicated to users have been activated for the remote management of hormone therapy. we use a web-based survey to assess the impact of covid-19 outbreak on trans-population health and to assess the specific needs of this population in this particular moment.

use of a dedicated web-based anonymous questionnaire to assess health needs of trans-population during covid-19 outbreak and to assess specific risk factors for covid-19 infection. evaluation of physical and psychological wellbeing of the trans-population during coivd-19 outbreak in italy using anonymous validated questionnaires (sf12, ies-r and beck depression inventory)

Eligibility criteria:
inclusion criteria: * transgender subjects * age \> 18 years exclusion criteria: - none
peristomal mesh for prophylaxis of parastomal hernia

Conditions: Hernia

Summary: the study aims to prove differences or equalities in outcome for patients operated with or without a peristomal mesh in the sublay position when establishing a permanent colostomy.

patients are randomized to 2 groups equal in number: a group with mesh implantation and a control group without mesh implantation. primary endpoint is parastomal hernia. secondary endpoints are operating time, infection, obstruction, stenosis, retraction, fistulae, skin related problems and reoperations. endpoints are correlated to body mass index, previous hernia, age, concurrent illness and cause for colostomy. patients are followed 4 years after operation with clinical examination

Eligibility criteria:
inclusion criteria: * condition with indication for establishing a permanent end-colostomy. exclusion criteria: * age under 18 * asa score above 3

Keywords: colostomy parastomal peristomal hernia mesh surgery indication for permanent end colostomy