Kornimate/medical-research-clean huggingface dataset:
a study to evaluate participant satisfaction and natural outcomes following administration of botox cosmetic injections in adult participants for treatment of upper facial lines

Conditions: Upper Facial Lines

Summary: facial lines that develop from repeated facial expression, such as glabellar lines (gl), lateral canthal lines (lcl), and forehead lines (fhl), are typically treated by selectively weakening specific muscles with small quantities of botulinum toxin. the purpose of this study is to evaluate participant satisfaction and natural outcomes following the administration of botox cosmetic in adult participants with upper facial lines (gl, lcl, and fhl). this is an open-label study in which all participants will receive active study treatment. around 100 adult participants with an assessment of moderate to severe gl, lcl, and fhl, will be enrolled at approximately 10 sites in the united states and canada. participants will receive botox cosmetic as intramuscular injections to the glabellar lines, lateral canthal lines, and forehead lines at day 1. participants will attend regular visits during the study. the effect of the treatment will be checked by medical assessments for side effects and questionnaires will be completed during regular study visits.


Eligibility criteria:
inclusion criteria: * moderate to severe glabellar lines, lateral canthal lines, and forehead lines. * sufficient visual acuity without the use of eyeglasses (contact lens use acceptable) to accurately assess their facial wrinkles. exclusion criteria: * presence or history of any medical condition that may place the participant at increased risk to botox cosmetic or interfere with the study evaluation. * presence of tattoos, jewelry, or clothing which obscures or interferes with the target area of interest and cannot be removed. * history of known immunization or hypersensitivity to any botulinum toxin serotype.

Keywords: glabellar lines lateral canthal lines forehead lines botox botulinum toxin type a onabotulinumtoxina upper facial lines crows feet lines wrinkles facial wrinkles facial rhytides
nutritional state and care pathway of hospitalized malnourished patients, within 3 months of admission

Conditions: Malnutrition

Summary: malnourished patients are at risk of many complications, including infections, pressure ulcers and readmissions. little is known about their care pathway after hospital discharge. this study aims to determine care pathways of malnourished patients after hospital discharge and to determine what they need to better take care of their malnutrition.

all patients hospitalized in the post-emergency unit of rennes university hospital during the study period will be screened for malnutrition. data concerning newly diagnosed malnourished patients will be recorded and those patients will be contacted 3 months after their hospital discharge. a qualitative study will be conducted among malnourished patients and their families : a sample of patients and their caregivers will be interviewed to better understand their perception of malnutrition and what they need to better take care of malnutrition.

Eligibility criteria:
inclusion criteria: * malnourished patients, hospitalized in the post-emergency unit during the study period, according to the malnutrition diagnostic criteria defined by the french health authority : * age ≥ 70 years old: weight loss ≥ 5% within 1 month or ≥ 10% within 6 months and/or bmi \<21 and or serum albumin level \< 35 g/l * age \< 70 years old : weight loss ≥ 5% in 1 month or ≥ 10% in 6 months or ≥ 10% compared to the usual weight before the onset of the disease; or bmi \<18.5 kg / m2 non-inclusion criteria : * refusing to participate in the study * age \< 18 years old * patients under tutorship or guardianship * patients living in retirement home * patients without a fixed address exclusion criteria : -patients transferred in another unit

Keywords: malnutrition, qualitative study
periodontitis and atherosclerotic-related arterial stenosis

Conditions: Atherosclerosis of Artery

Summary: this study aimed to evaluate the association between periodontitis and atherosclerosis of the cerebral vasculature in the chinese population.

periodontitis has been demonstrated as a risk factor for ischaemic stroke in several clinical studies. atherosclerosis of the cerebral vasculatureis an important pathological process causing ischaemic stroke. the investigator's study aims to investigate the relationship between tooth loss(used as a surrogate of periodontal disease) and atherosclerotic-related arterial stenosis in the chinese population. an estimated 1,000 participants that underwent cerebral angiography at guangdong provincial hospital of chinese medicine between apirl 2020 and january 2022 will be recruited in this trial. arterial stenosis features of each participants will be collected based on the results of digital subtraction angiography (dsa). the missing teeth counts of each participant will be collected and some of them will recieved comprehensive periodontal examination. besides, blood samples will be collected in order to investigate the serum inflammatory markers(crp,wbc,albumin,il-6,il-10). the relationship between tooth loss and atherosclerotic-related arterial stenosis will be analysed by regression models adjusted for conventional risk factors (sex,age, obesity,smoking,alcohol drinking,diabetes,hypertension,hyperuricaemia,hyperhomocysteinaemia)

Eligibility criteria:
inclusion criteria: 1. subjects who underwent cerebral angiography at guangdong provincial hospital of chinese medicine from april 2020 to december 2021 2. subjects who voluntarily participated in this study and provided informed consent. exclusion criteria: 1. intracranial and extracranial artery stenosis caused by vascular inflammation, systemic connective tissue disease, and muscle fibre structure hypoplasia 2. inability to cooperate with the investigation 3. intracranial aneurysm and cerebral arteriovenous malformation confirmed by cerebral angiography 4. receipt of periodontal treatment in the previous 24 months.

Keywords: arterial stenosis periodontitis atherosclerosis risk factors
exercise capacity in response to enzyme replacement therapy in pediatric pompe disease.

Conditions: Pompe Disease Infantile-Onset

Summary: our aims are to investigate the acute and long term effect of ert on exercise capacity; comparing the effect of different ert dosages (as prescribed by the clinician according to clinical judgment) and assessing the relationship between enzyme blood level and exercise capacity. such evaluation may allow a more objective quantification of the response to ert.

pompe disease is a rare autosomal recessive metabolic myopathy caused by reduced or absence activity of the lysosomal enzyme acid alpha-glucosidase (gaa). enzyme replacement therapy (ert) with myozyme has significantly improved the prospect of patients with infantile pompe disease (ipd). most ipd patients show clinical improvement on therapy, but deteriorate at different time points, raising the possibility that increasing drug delivery might halt the progression of the disease. data on the effects of ert therapy on physiological variables related to exercise tolerance is scarce. our aims are to investigate the acute and long term effect of ert on exercise capacity; comparing the effect of different ert dosages (as prescribed by the clinician according to clinical judgment) and assessing the relationship between enzyme blood level and exercise capacity. such evaluation may allow a more objective quantification of the response to ert. methods: a retrospective - prospective study evaluating pediatric patients with pompe before and 2 days after ert on multiple occasions and different dosing. evaluation included cardiopulmonary exercise testing (cpet), 6 minute-walking test (6mwt), motor function test (gmfm-88) and self-collected blood samples (on a guthrie card) for enzyme blood levels.

Eligibility criteria:
inclusion criteria: * pompe patients \>5 years that have been on alpha-glucosidase (gaa). exclusion criteria: * oxygen saturation \> 90% in room air without ventilatory assistance. * patients will be excluded if they required any invasive ventilation or if they required noninvasive ventilation while awake and upright
the sexual health of rectal cancer patients

Conditions: Rectal Cancer; Rectum

Summary: we know that treatment for rectal, colorectal or anal cancer can impact sexual function. this study aims to learn: * how the treatment affects emotional and social well-being. * how a new sexual health educational program affects you. cancer patients seek education for lots of reasons. it often helps them cope because they can express their feelings with a trained professional. this study is open to individuals who have been treated for rectal, colorectal or anal cancer. it involves a new type of sexual health counseling program. it will teach participants skills that they can use to improve their sex lives. these skills may also improve physical and emotional well-being. we will compare the new type of sexual health program with the standard care patients receive after treatment for rectal, colorectal or anal cancer.

this is a two year randomized clinical trial examining the feasibility, tolerability, acceptability (including adherence) and efficacy of an intervention designed to improve sexual functioning of survivors of rectal cancer. we have completed enrollment of female patients and are currently collecting follow up data. recruitment for male patients is ongoing. male participants will now be randomized in a 3:1 ratio to either the intervention condition (n = 40) or the control condition (n = 40).

Eligibility criteria:
inclusion criteria: * at least six months post radiation and/or surgery for stage i-iii rectal adenocarcinoma or rectosigmoid for cancer with an anastomosis at 15 cm or below and completed treatment * at least six months post radiation and/or chemotherapy for anal cancer. * have no evidence of disease or recurrence * for women indicate indicate moderate satisfaction or below on their overall sexual life (a score of "4" or lower on the question "over the past 4 weeks, how satisfied have you been with your overall sexual life?" * for men indicate, and a score of "3" or lower on the question "how would you rate your confidence that you could get and keep an erection" for men) and a score of "2" or higher on the question "how much does this problem bother you? * in the judgment of the consenting professional interventionists, able to communicate in english well enough to work with english speaking and complete the study assessments. * age 21 years or older. exclusion criteria: * significant cognitive or psychiatric disturbance sufficient, in the investigator's judgment, to preclude participation in a psychotherapeutic intervention. * are actively participating in protocol 06-151 * participated in focus group or qualitative interview.

Keywords: rectum quality of life sexual health 08-073
blood flow restriction strength training in professional soccer players

Conditions: Resistance Training; Blood Pressure

Summary: the aims of this clinical study are evaluated the effects of blood flood restriction training on the sport performance of professional and semi-professional soccer players. the participants are twenty male professional and semi-professional soccer players who are playing at rcd mallorca. participants will be assigned in two different groups. both groups develop for six weeks a strength training programs. the first group will base their training in low load using blood flow restriction (20-50% of one maximum repetition). the second group will base their training in high load (60-80% of one maximum repetition). this training program includes three type of exercises in each training session; back squat, single deadlift and barbell hip thrust. before and after this program the investigators will collect sociodemographic and anthropometrics data. on top of that, the investigators will evaluate the muscle mass, the electrical activity produced by skeletal muscles, the muscle strength and the sprint ability of every participant. before to the evaluation, the soccer players will warm-up during 15 minutes under the control of the evaluators.

participants: participants are soccer players of rcd mallorca (second spanish football division) and rcd mallorca b (third spanish football division).before to start the study, every participant will receive an informed consent about the clinical study. this informed consent will be signed by them according to declaration of helsinki. at the same time, the data will be anonymized and only the main researcher of the study will have access to it, to ensure compliance with the data protection law. w-up: the warm-up will consist of 5 minutes running slow (treadmill), 5 minutes mobility, and 5 minutes of running exercises. in addition, the warm-up will contain a familiarization with the jump test

Eligibility criteria:
inclusion criteria: * no injuries in the last 6 months * 1 years experience minimun in the division. exclusion criteria: * amateurs players

Keywords: strenght training soccer blood flood restriction performance sport injuries
a population-based investigation of related factors of birth weight in china

Conditions: Risk Factors; Birth Weight

Summary: the purpose of this study is to establish chinese neonatal network to investigate current situation of neonatal birth weight and related factors. we investigated the risk factors such as sex, gestational age, region, nation, altitude, place of residence, maternal occupation, education level of mother, maternal age, maternal pregnancy diseases and multiple births.


Eligibility criteria:
inclusion criteria: * live births * gestational age between 24 weeks and 43 weeks exclusion criteria: * major malformation * physical deformity * fetal edema * body mass diagnosed in prenatal ultrasound * acute blood loss during delivery
the effect of head positioning on the cross-sectional area of the subclavian vein.

Conditions: Normal Volunteers

Summary: in the present study, the cross-sectional area of subclavian vein, the distances of subclavian vein \~ subclavian artery and subclavian vein \~ pleura are assessed in different head positions (neutral, rotation to ipsilateral or contralateral sides) in spontaneous breathing adults.


Eligibility criteria:
inclusion criteria: * healthy adults exclusion criteria: * medication affecting vascular elasticity * history of central venous catheterization or clavicle fracture * history of lung surgery, operation of chest cage

Keywords: subclavian vein
effect and mechanism of remimazolam benzenesulfonate on enhanced recovery after surgery in patients undergoing radical gastrectomy for gastric cancer

Conditions: Remimazolam Benzenesulfonate on Nenhanced Recovery After Surgery; Possible Molecular Mechanism of Remimazolam Benzenesulfonate

Summary: the purpose of this study is to discuss the benzene sulfonic acid red horse azole shimron the occurrence of postoperative complications in patients with gastric cancer radical and its severity, at the same time, comparing the control group (propofol) the degree of inflammation in patients with different time points difference, preliminary in this paper, the benzene sulfonic acid red horse azole shimron in gastric cancer radical viscera molecular mechanism of protection and quick recovery.

a total of 60 patients undergoing radical gastrectomy for gastric cancer were randomly divided into control group (group p) and experimental group (group r), with 30 cases in each group. two groups are made by way of bis target controlled infusion of anesthesia, experimental group (r group) target controlled infusion red horse azole shimron, control group (p group) target controlled infusion of propofol, bis values are controlled in 50 + 5, postoperative observation of dynamic changes of inflammatory cytokines in plasma, postoperative adverse reactions, postoperative recovery, postoperative 30-day mortality and postoperative complications. through statistical analysis, it is proposed that remazolam can stabilize perioperative hemodynamic fluctuation, improve postoperative recovery, reduce the release of inflammatory mediators, reduce complications, shorten the length of hospital stay, reduce hospitalization costs, and accelerate the rapid recovery of patients with radical gastrectomy. it is proved that remazolam besylate can reduce the inflammatory response of patients undergoing radical gastrectomy, reduce the incidence of postoperative complications, and provide a favorable supplement to eras in patients undergoing radical gastrectomy. at the same time provide more red horse azole shimron, applied to the systemic narcotic induction and maintenance of cases and further added red horse azole shimron applied to clinical usage and dosage (by age, gender, race, obesity status, asa grade and weight the effect of covariate), adverse reactions, and other commonly used anesthetic synergy.

Eligibility criteria:
inclusion criteria: sixty patients undergoing elective laparoscopic radical gastrectomy for gastric cancer; aged 18-75 years; asa≤ⅲ . - exclusion criteria: emergency surgery or non-radical gastrectomy patients; age \ 75 years old, asa grade ≥iv. benzodiazepines or other narcotic drug allergy patients; patients with neurological and psychiatric disorders, long-term use of sedatives or antidepressants; has a history of alcoholism or drug dependence; intraoperative find distant metastasis; receive radiation and chemotherapy, cachexia; patients with a history of other malignant tumors within five years; the patient refused to participate in the study. -

Keywords: remimazolam benzenesulfonate eras radical gastrectomy for gastric cancer
a study comparing upadacitinib (abt-494) monotherapy to methotrexate (mtx) monotherapy in adults with rheumatoid arthritis (ra) who have an inadequate response to mtx (select-monotherapy)

Conditions: Rheumatoid Arthritis

Summary: the study objective of period 1 of this study is to compare the safety and efficacy (signs and symptoms) of upadacitinib 30 mg once daily (qd) alone and upadacitinib 15 mg qd alone versus continuing mtx alone adults with moderately to severely active rheumatoid arthritis (ra) with an inadequate response to mtx. the study objective of period 2 is to evaluate the long term safety, tolerability, and efficacy of upadacitinib 30 mg qd and 15 mg qd in adults with ra who had completed period 1.

the study includes a 35-day screening period; a 14-week randomized, double-blind, parallel-group, controlled treatment period (period 1); a 246-week blinded extension period (period 2); and a 30-day follow-up visit. participants who met eligibility criteria were to be randomized in a 2:2:1:1 ratio to one of four treatment groups: * group 1: upadacitinib 30 mg qd (period 1) → upadacitinib 30 mg qd (period 2) * group 2: upadacitinib 15 mg qd (period 1) → upadacitinib 15 mg qd (period 2) * group 3: mtx (period 1) → upadacitinib 30 mg qd (period 2) * group 4: mtx (period 1) → upadacitinib 15 mg qd (period 2) starting with implementation of protocol amendment 5, all participants in the extension period will receive open-label upadacitinib 15 mg qd, including those currently on upadacitinib 30 mg qd.

Eligibility criteria:
inclusion criteria: * diagnosis of ra for \>= 3 months. * subjects must have been on oral or parenteral mtx therapy \>= 3 months and on a stable dose for \>= 4 weeks prior to first dose of study drug. * must have discontinued all conventional synthetic disease-modifying anti-rheumatic drugs (csdmards) (other than mtx) \>= 4 weeks prior to first dose of study drug. * meets the following minimum disease activity criteria: \>= 6 swollen joints (based on 66 joint counts) and \>= 6 tender joints (based on 68 joint counts) at screening and baseline visits. exclusion criteria: * prior exposure to any janus kinase (jak) inhibitor (including but not limited to tofacitinib, baricitinib, and filgotinib). * prior exposure to any biological disease-modifying anti-rheumatic drugs (bdmards). * current diagnosis of inflammatory joint disease other than ra. current diagnosis of secondary sjogren's syndrome is permitted.

Keywords: musculoskeletal disease arthritis joint disease anti-inflammatory agents antirheumatic agents upadacitinib abt-494
evaluating electrocardiogram (ecg) abnormalities from young adulthood through middle age

Conditions: Cardiovascular Diseases

Summary: an electrocardiogram (ecg) is a test that evaluates the electrical activity of the heart and can be used to detect heart problems. by analyzing ecgs collected over a 20-year period, this study will examine ecg abnormalities and the differences in ecg findings between black and white people, from young adulthood through middle age.

an ecg is a test that detects and records the electrical activity of the heart. as a diagnostic tool, it can detect and locate the source of heart problems, including heart attacks, irregular heart beats, cardiovascular disease, or other abnormalities of the heart. an ecg procedure involves attaching electrodes to the skin on the chest, arms, and legs while the electrodes detect electrical signals of the heart, and a machine displays the signals on a computer screen and graph paper. an ecg may be a beneficial way to detect cardiovascular disease because it is a low-cost and non-invasive test that is widely available in the clinical setting. this study will examine ecgs and other study data from participants in the coronary artery risk development in young adults (cardia) study. as ecg abnormalities typically begin to develop in young adults, the cardia participants will provide researchers with an excellent study population. as part of the cardia study, ecgs were obtained from participants at baseline, and years 7 and 20. study researchers will use state-of-the-art technology and standardized minnesota code and novacode methods to electronically code participants' ecgs and accomplish the following: 1) assess the frequency of ecg abnormalities in young adults of different races; 2) examine potential risk factors for the development and progression of ecg abnormalities; 3) investigate the relationship between ecg abnormalities and other measures of heart disease; and 4) assess differences in the frequency and patterns of ecg abnormalities between different racial groups. study researchers will also analyze additional cardia study data, including cardiovascular disease risk factors, measures of atherosclerosis, and echocardiographic ultrasound pictures of the heart. this research will provide important insights into the ways in which ecg abnormalities are associated with increased risk for cardiovascular disease and how the risk may differ between blacks and whites. results from this study may ultimately lead to improvements in preventive strategies for cardiovascular disease in young adults.

Eligibility criteria:
inclusion criteria: * participated in the cardia study

Keywords: electrocardiogram electrocardiography cardiovascular risk factors cholesterol blood pressure diabetes