Kornimate/medical-research-clean huggingface dataset:
ventilatory response after non invasive ventilation in type 1 myotonic dystrophy

Conditions: Myotonic Dystrophy 1; Steinert Disease

Summary: it has been suggested that patients with myotonic dystrophy type 1 have primary altered ventilatory response to chemical stimuli and chronic hypoventilation is related not always to muscle weakness. also, it is known that non invasive mechanical ventilation can improve ventilatory response to chemical stimuli, especially to hypercapnia. this study evaluates the effect of non invasive mechanical ventilation on ventilatory response in patients with type 1 myotonic dystrophy, the ventilatory response to chemical stimuli will be measured before and after mechanical ventilation in patients with myotonic dystrophy type 1.

type 1 myotonic dystrophy is a hereditary neuromuscular disease with an autosomal dominant pattern whose prevalence is 1/8000 inhabitants and is the most common muscular dystrophy in adults. it is multisystem disease and is characterized by myotonia, progressive muscle loss and a wide spectrum of manifestations. myotonic dystrophy type 1 causes a high impact on health and quality of life of patients as functional impairment can reach the incapacity and total dependence in basic activities of daily living. as in most neuromuscular diseases, progressive muscle weakness at some point in the evolution affects the respiratory muscles. however, in some patients with myotonic dystrophy type 1 it has been observed that muscle weakness does not explain ventilatory failure, and is believed to be due to a primary reduction in the central ventilatory response to hypercapnia present in this disease. non invasive mechanical ventilation (niv) is a long-term treatment that provides ventilatory assistance through an interface that does not invade the airway and currently can be provided to patients in the home environment; it is a resource that has shown to improve the quality of life, daytime gas exchange and survival in patients with neuromuscular diseases, even when used only during sleep. it is not clear the mechanism by which niv during daytime sleep improves gas exchange in patients with neuromuscular diseases, even in advanced stages where breathing muscles effectors are severely affected. it has been proposed that niv used during sleep can improve the sensitivity of the respiratory center to carbon dioxide but this has not been demonstrated in patients with type 1 myotonic dystrophy, to answer this question, it is proposed to compare the central ventilatory response to chemical stimuli after a period of niv in patients with type 1 myotonic dystrophy.

Eligibility criteria:
inclusion criteria: * classic variety of myotonic dystrophy type 1 * molecular confirmation through the standard method exclusion criteria: * using currently invasive mechanical ventilation. * acute decompensation of respiratory or cardiac origin in the last 6 months, which required hospital care. * drugs that may alter the ventilatory response: benzodiazepines, neuroleptics, corticosteroids, theophylline, acetazolamide

Keywords: myotonic dystrophy noninvasive ventilation respiratory failure
losartan and simvastatin in hypertensive obeses with liver steatosis

Conditions: Hypertension

Summary: angiotensin ii has been proposed as a lipid metabolism regulator. it is known that adipocytes secrete a variety of protein, such as tnfα, plasminogen activator inhibitor (pai)-1, leptin, resistin and adiponectin; these proteins have a wide range of biological effects and are associated with insulin resistance. adipocytes also produce angiotensinogen and angiotensin ii and a local renin-angiotensin system (ras) is present in adipose tissue. in overweight or obese hypertensive normocholesterolemic patients the treatment with at1-receptor blocker (losartan) may have a better effect on hepatic steatosis and visceral fat deposition than the antihypertensive treatment with calcium channel blocker (amlodipine). simvastatin will be added to both groups. the aim of this study is to evaluate the effect of losartan and simvastatin on ultrasonographic qualitative and quantitative parameters in overweight or obese hypertensive normocholesterolemic patients with hepatic steatosis.


Eligibility criteria:
inclusion criteria: * gender: 50% male and 50% female * age: 40-80 years * race: caucasian * overweight or obese: respectively bmi25-30 kg/m2 or bmi \> 30 kg m2 * hypertensive: pa \> 140/90 mmhg * normocholesterolemic (ldl\ 35 mg/dl) * liver steatosis exclusion criteria: * other antihypertensive treatment after wash out period of 2 weeks * abnormal heart rest function (ef \< 55%). * valvular heart disease * congenital heart disease * heart failure or prior myocardial infarction * diabetes * renal disease * liver disease * connective tissue disease * pregnancy or lactation * serious adverse experience * sensitivity to the study drugs or its components * contraindication from an approved label

Keywords: essential hypertension liver steatosis
implementation of a multiple intervention to promote healthy lifestyles in patients with depression

Conditions: Major Depressive Disorder (MDD)

Summary: this clinical trial aims to investigate whether an integrative approach combining education on the mediterranean diet and physical activity (pa) can significantly reduce depressive symptomatology in individuals with major depressive disorder. the study will evaluate changes in depressive symptoms and assess biological modulations, including alterations in the gut microbiota and inflammatory markers, resulting from the pa intervention. participants will be randomized into two arms: the active control group will attend a series of lessons focused on the mediterranean diet, while the experimental group will participate in the same dietary lessons combined with a structured pa program of 12 weeks.


Eligibility criteria:
inclusion criteria: * primary diagnosis of depression (dsm-5 criteria, american psychiatric association 2013). * depressive symptoms assessed using madr, bdi, or zdr scales. * ability to provide written informed consent. * self-reported moderate-intensity leisure physical activity of less than 150 minutes per week. exclusion criteria: * patients with severe psychopathology. * medical contraindications to physical activity. * orthopedic problems or other conditions limiting physical fitness assessment or currently pregnant. * patients who underwent antibiotic/anti-inflammatory treatments in the last 3 months * active gastrointestinal diseases * autoimmune and/or chronic inflammatory disorders

Keywords: major depressive disorder physical activity mediterranean diet microbiome
patient satisfaction scales

Conditions: All Orthopedic Disorders; New or Follow-up Patients

Summary: this study aims to assess differences between 4 types of single satisfaction measures. secondly, if there is a difference in satisfaction between english speaking and spanish speaking patients.


Eligibility criteria:
inclusion criteria: * all new or return patients seeing a ue / le surgeon * age 18-89 * able to provide informed consent * english speaking * ut health austin musculoskeletal institute, austin regional clinic, seton institute for plastic and reconstructive surgery, orthopaedic specialists of austin, texas orthopedics, and atx ortho. exclusion criteria: * not fluent in english
effect of pentoxifylline on endothelial dysfunction in patients with acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: this study aims to investigate the effect of pentoxifylline administration on the status of endothelial function and oxidative stress biomarkers in patients with acute coronary syndrome (acs).

the study will be carried out at ain shams university hospitals. patients with acs who meet the eligibility criteria and consent to participate in the study will be randomly allocated to either the intervention group or the control group. all participants will receive the standard pharmacologic treatment for acs according to the applied guidelines offered by the facility. in addition, patients in the intervention group will receive pentoxifylline tablets 400mg orally three times daily. patient follow-up will be scheduled every 2 weeks for each patient to check the tolerability, the development of side effects, any medication change and medication adherence. physical examination at each visit will be done by physician in attendance for all patients in both groups. a blood sample will be taken at baseline and at the end of the study after 2 months. for measurement of basic laboratory parameters (complete blood count, liver function tests, kidney function tests ,..etc), the level of soluble vascular cell adhesion molecule-1 (svcam-1) as a marker for endothelial dysfunction, the level of malondialdehyde (mda) as a marker for oxidative stress.

Eligibility criteria:
inclusion criteria: * patients aged 18-80 years old. * recent acs diagnosed-patients within the past 2 weeks. exclusion criteria: * known allergy to pentoxifylline * heart failure new york heart association (nyha) class iii or iv * severe left ventricular dysfunction (left ventricular ejection fraction \<30%) * high serum creatinine level ≥ 2 mg/dl * liver disease (baseline alanine transaminase \>2.5 times the upper limit of normal) * active bleeding or bleeding diathesis * major surgery or trauma within 1 month * recent cerebral and/or retinal hemorrhage within 3 months

Keywords: acute coronary syndrome pentoxifylline endothelial dysfunction oxidative stress
the impact of yoga on blood pressure and quality of life in patients with hypertension

Conditions: Hypertension

Summary: the purpose of this study is to determine the effects of yoga on blood pressure and quality of life in patients in primary health care diagnosed with hypertension within the last year. another purpose is to examine whether the possible effect on blood pressure differs if patients practice yoga in a group lead by a yoga-trainer or receive a few yoga-exercises from their doctor to be practiced individually at home.

hypertension is one of the most common diseases in the industrialized world. in sweden alone approximately 1.8 million persons, 25% of the adult population, have hypertension. hypertension is a common diagnosis in primary health care and the costs of investigating and treating hypertension and its consequences are considerable. we know that stress can affect blood pressure, but it is hard to measure and control. previous studies have separately shown that yoga can reduce levels of cortisol in saliva and lower blood pressure. however, few studies have investigated the effects of yoga on hypertension and we lack information about the possibility of using yoga in primary health care to reduce hypertension. if yoga can be used to complement antihypertensive medicines, it could reduce medicine intake and thereby possibly reduce side effects and lower medicine costs. it is to be hoped that patients will also experience a higher quality of life if they perform yoga on a regular basis.

Eligibility criteria:
inclusion criteria: * diagnosed with hypertension since at least one year. * blood pressure 120/80-160/100 mmhg at the last blood pressure control by doctor or nurse. exclusion criteria: * blood pressure \>180 systolic and/or \>110 diastolic by the initial control in the study. * blood pressure \<120 systolic by the initial control in the study. * medical adjustments regarding hypertension within 4 weeks prior to begin of study. * expected inability to understand instructions about yoga exercises (e.g dementia and mental retardation) or physical or psychical inability to carry out yoga exercises (e.g severe physical or psychical handicap). * need for interpreter. linguistic/language difficulties * older than 80 years

Keywords: yoga hypertension quality of life primary health care
iron fish in dominican republic (dr) children

Conditions: Iron Deficiency Anemia; Anemia; Iron-deficiency

Summary: the objective of the study is to assess the acceptability, feasibility, and barriers to lucky iron fish™ (lif) utilization among families with young children in a latin american community with a high prevalence of iron deficiency and iron-deficiency anemia. .

the primary objective is to assess the acceptability of cooking with an iron ingot (lucky iron fish™) compared to traditional oral iron supplementation methods among preschool aged children in a dominican community with a high prevalence of anemia (\> 50%). data will be collected to characterize the natural history of iron deficiency and anemia in pre-school aged children in a dominican community. the study will involve a randomized control trial to assess the primary objective: children \> 1 year and \< 5 years of age will be randomized into two study arms: lif plus citrus (lif arm) versus standard iron-supplementation (enhanced standard of care). participants enrolled in the both study arms will have study labs drawn every 3, 6, and 12-months (hemoglobin, serum ferritin, c-reactive protein) to assess the natural history of iron deficiency in these children. concomitant to study labs, parents/guardians will be surveyed on acceptability, compliance, and barriers to use of their assigned iron supplementation method. primary study outcomes are the change in hemoglobin within the lif group and then difference in change in hemoglobin between study arms over a 12-month study period. secondary outcomes include changes in serum ferritin within and between study arms and exploring the relationship between changes in hemoglobin, serum ferritin, and c-reactive protein

Eligibility criteria:
inclusion criteria: * parent/guardian ≥ 18 years of age * child \> 1 year and \< 5 years of age * child followed by niños primeros en salud (nps) * parent/guardian is spanish speaking * parental/guardian permission is provided (informed consent) exclusion criteria: * mother/infant pairs enrolled in related protocol of this study * inability to understand and speak spanish * severe cognitive impairment or severe psychiatric disease which would prohibit the answering of study questions * child followed by nps malnutrition program * persons receiving pre-designed nutrient-fortified foods or participation in another nutrition program * child has documented sickle cell disease

Keywords: iron intake iron bioavailability
effect of cocoa consumption in cardiovascular and immune parameters

Conditions: Arterial Hypertension

Summary: arterial hypertension is one of the most preventable risk factors for stroke, cardiovascular and renal disease. cocoa is rich in a subclass of flavonoid called flavanol this increase nitric oxide production and is involved in controlling blood pressure.


Eligibility criteria:
inclusion criteria: * age: 18 - 65 years old * resides in medellín city * attached from the contributive regimen of colombian health system * essential arterial hypertension, stage i. diagnosis less than 3 months. * medically indicated non-pharmacological therapy. * voluntary desire to consume 50 grams of chocolate per day for 12 weeks. * voluntary desire to participate in the trial and sign informed consent. exclusion criteria: * suspect of secondary hypertension * suspect of injury in target organ * presence of diabetes mellitus * bmi (body mass index) major or equal to 30 * present smoker or with less than four weeks of abstinence of tobacco * consume antiplatelet substances * regular consumption of antioxidants, multivitamins, anti-inflammatory medications, drugs for nasal congestion and sibutramine
(val)ganciclovir tdm in transplant recipients

Conditions: Cytomegalovirus Infections

Summary: the aim of this study is to gain more insight into therapeutic drug monitoring and thus the pharmacodynamics and pharmacokinetics of ganciclovir, in the context of prophylaxis and treatment of cmv infections, in order to provide the patient with an adequate dose.

patients undergoing solid organ or stem cell transplantation are at risk of developing cytomegalovirus (cmv) infection or reactivation. the risk of cmv infection / reactivation and its severity depends on the cmv serostatus of donor and recipient. valganciclovir (oral pro-drug of ganciclovir) prophylaxis is used to postpone cmv infection or reactivation to a later point in the post-transplantation. cmv infection/reactivation does not always lead to clinical disease. valganciclovir (oral) can be used when cmv dna is detected in the blood, but patient has no or few complaints. however, in case of severe symptoms such as colitis, nephritis, hepatitis, pneumonitis, uveitis or encephalitis (active cmv disease) then ganciclovir is indicated intravenously. in clinical recovery treatment is often completed with valganciclovir. it is important that the ganciclovir level is adequate, because too high level can lead to side effects such as cytopenia and a too low level can lead to treatment failure and resistance development. there are different dosing schedules mentioned in different sources. these schemes are based on dated literature. the aim of (val)ganciclovir therapeutic drug monitoring (tdm) is to gain more insight into the pharmacodynamics and pharmacokinetics of ganciclovir, in the context of prophylaxis and treatment of cmv infections, in order to provide the patient with an adequate dose.

Eligibility criteria:
inclusion criteria: * must receive ganciclovir intravenously or valganciclovir orally as routine care * must have received a solid organ or stem cell transplant * must be be 18 years or older exclusion criteria: there are no exclusion criteria.

Keywords: ganciclovir valganciclovir therapeutic drug monitoring pharmacokinetics
inflammation in an ultra endurance race

Conditions: Inflammation; Inflammatory Response

Summary: the aim of this study is to study the per and post-exertional variations of the pro and anti inflammatory markers during an ultra-endurance race in healthy volunteers.

study per and post-exertional changes in proinflammatory biological (il1, il6, tnf alpha, hmg beta1 and crp) and anti inflammatory parameters (il4, il10 and il13, tgf beta, lps, lipoproteins, lipids) during an ultra endurance race.

Eligibility criteria:
inclusion criteria: 1. male older than 18 years, 2. completion of an ultra-endurance race (distance greater than 50 kilometers) during the 24 months preceding the race. 3. affiliation or beneficiary of a social security. exclusion criteria: 1. age lower than 18 years, 2. subjects with a medical history (pulmonary pathology, cardiac, hypertension) or with a significant chronic inflammatory disease observed during the inclusion visit (the day before the race). 3. female.

Keywords: inflammation exercise ultra endurance
oxytocin receptor expression in pregnancy

Conditions: Post-Abortion; Hemorrhage, Obstetric

Summary: this study aims to determine when during gestation oxytocin receptor (oxtr) expression increases in the myometrium, which will contribute new insight to the management of obstetric hemorrhage and our understanding of normal and abnormal labor.

in this descriptive study, we will obtain myometrial tissue samples by core needle biopsy under ultrasound guidance in anesthetized women immediately following surgical abortion and from controls, all of whom are undergoing a separate planned obstetric/gynecologic surgery. tissue studies will be performed on these biopsy samples to examine oxytocin receptor expression and function.

Eligibility criteria:
inclusion criteria: * women age 18-50 * gestational age 14-26 weeks; or 6-13 weeks, 37-42 weeks, or non-pregnant (controls) * undergoing another planned surgical procedure with anesthesia (suction d\&c, d\&e, gravid hysterectomy, cesarean section, or laparoscopic tubal ligation) * able to give informed consent in english or spanish exclusion criteria: to optimize biopsy safety, we will exclude patients with anticipated difficult cases, that have additional risks of hemorrhage, or those with features that limit ultrasound visualization. increased risk of hemorrhage: * anemia (hgb \< 9) * anticoagulation, bleeding disorder, or coagulopathy * multiple gestation * infection or sepsis for ultrasound-guided procedures: * obese, bmi ≥ 40 * history of ≥2 cesarean sections * large fibroids or uterine anomalies obstructing view * other poor visualization * thin myometrium \< 1cm

Keywords: post-abortion hemorrhage obstetric hemorrhage preterm labor abnormal labor oxytocin oxytocin receptor
hemiarthroplasty compared to total hip arthroplasty for displaced femoral neck fractures in the elderly-elderly

Conditions: Femoral Neck Fractures

Summary: total hip arthroplasty is equal to or better than hemiarthroplasty in the treatment of displaced femoral neck fractures in the elderly-elderly

total hip arthroplasty is equal to or better alternative to hemiarthroplasty in the treatment of displaced femoral neck fractures in the elderly-elderly (patients 80 years and over).

Eligibility criteria:
inclusion criteria: * acute displaced femoral neck fracture of hip (garden classification 3-4) * independent walker with or without walking aides * patient willing to participate in the study and give written consent. exclusion criteria: * fracture older than 36 hours before admission * osteoarthritis in the fractured hip * rheumatoid arthritis in the fractured hip * pathological fractures * contraindication for hip arthroplasty surgery * not suitable for inclusion for other reasons e.g. substance abuse
inflammation biomarkers in the diagnosis of postoperative infectious complications in colorectal cancer surgery

Conditions: Colorectal Cancer

Summary: this is a longitudinal, single-center, prospective study to determine the efficiency of wbc count, crp, pct, neutrophil cd64 and monocyte human leukocyte antigen- dr in the diagnosis of postoperative infectious complications in colorectal cancer surgery

blood samples for inflammation markers are carried out from patients with сolorectal cancer surgery in a single center on the day of the surgery in the operating room before intravenous fluid application started. each patient receives systemic antibiotic prophylaxis for gramnegative and anaerobic bacteria on induction of anesthesia and prior to skin incision. a standardized protocol for general and epidural anesthesia is used. values of wbc count, crp, pct, cd64n and hla-dr monocyte are recorded before surgery and after surgery on pod (postoperative day) 1, 3 and 6 or 7. sirs criteria on pod 1, 3, 6 or 7 and postoperative infections up to 30 days after surgery are recorded. ssis (incisional, organ / space), pneumonia, central venous catheter related bloodstream infections (crbsis), urinary tract infections (utis) and enterocolitis records are taken. microbial cultures are using as the gold standard. criteria for sirs reconsidered in the year 2001 by sccm / esicm / accp / ats / sis international sepsis definitions conference and criteria for dosage control and prevention (cdc) are taken into consideration. after discharge, each patient is being monitored by outpatient clinic examinations. the study will recruit approximately 100 patients during three consecutive years.

Eligibility criteria:
inclusion criteria: * have a elective colorectal resection for colorectal cancer * have signed approved informed consent form for the study exclusion criteria: * significant simultaneous surgical procedure (e.g., liver resection of metastasis) * bacterial infection at the time of surgery or antimicrobial therapy up to 4 weeks before surgery * neo-adjuvant chemotherapy and/or radiotherapy * autoimmune conditions * inflammatory bowel diseases

Keywords: colorectal cancer biomarkers neutrophil cd64 monocyte human leukocyte antigen - dr postoperative infectious complications c-reactive protein (crp) procalcitonin (pct)