Kornimate/medical-research-clean huggingface dataset:
carnosine supplementation and cardiovascular function

Conditions: Carnosine

Summary: carnosine is a dipeptide synthesized in the body from β-alanine and l-histidine. it was originally discovered in skeletal muscle where it is present in larger amounts than in other tissues, but it is also found in high concentrations in the brain, heart, and gastrointestinal tissues of humans. although its physiological role has not been completely understood yet, carnosine is a non-enzymatic free-radical scavenger and a natural antioxidant and has anti-inflammatory and neuroprotective properties. the hypothesis of this research is that the consumption of carnosine supplements in the form of capsules, as well as chicken meat enriched with carnosine (functional food) has a beneficial effect on vascular reactivity measured in different vascular basins, and the lipid profile with a positive effect on the reduction of oxidative stress and inflammatory response in healthy sedentary people. subjects and active athletes measured in different vascular basins. the main goal of this study is to investigate the influence of carnosine supplement consumption (in the form of capsules and functional food) on vascular and endothelial function in a population of healthy young subjects and active athletes.


Eligibility criteria:
inclusion criteria: * young healthy sedentary individuals - did not perform regular physical activities for at least 12 months before conducting the study * young healthy active athletes - have a minimum of 5 training sessions per week (mainly endurance training) for at least 12 months prior to conducting the study exclusion criteria: * smoking * hypertension * coronary disease * diabetes * hyperlipidemia * kidney damage * cerebrovascular and peripheral artery diseases * and any other disease that could have an impact on vascular and endothelial function

Keywords: carnosine oxidative stress vascular reactivity endothelium inflammation microcirculation macrocirculation
perioperative coagulation management in cardiac surgery.

Conditions: Cardiac Surgery; Bleeding

Summary: cardiac surgery is bleeding requiring transfusion surgery . the haemorrhagic is related to the need to use high doses of anticoagulants to prevent thrombosis of blood . moreover, this type of surgery is platelets and coagulation factors consumming despite conducting a thorough anticoagulation. all these changes contribute to increase the need for transfusions during heart surgery. the main objective of this study is to compare the need for transfusions in patients suffering from bleeding complications after cardiac surgery with a therapeutic algorithm based on the use of rotem ® versus standard tests based solely on standard laboratory tests. 100 pateinst (50 in each arm) should be included in this trial.


Eligibility criteria:
inclusion criteria: * adults\> 18 years * cardiac surgery or heart transplantation with abnormal bleeding regardless the etiology * given informed consent exclusion criteria: * patient supported by a pre or postoperative circulatory technical assistance

Keywords: coagulation management cardiac surgery bleeding rotem
effect of 3 years of exercise in patients with atrial fibrillation

Conditions: Atrial Fibrillation

Summary: this is a substudy of "generation 100". the investigators will follow the persons with atrial fibrillation to see if 3 years of interval or moderate exercise affects the burden of atrial fibrillation, symptoms, use of health services or echocardiographic findings.


Eligibility criteria:
inclusion criteria: * included in the "generation 100 study" * atrial fibrillation diagnosis verified by ecg exclusion criteria: -

Keywords: atrial fibrillation exercise
clinical evaluation of a new cancer diagnosis center at kristianstad general hospital, sweden

Conditions: Cancer

Summary: the aim of this study is to evaluate a new cancer diagnosis center (diagnostiskt centrum, dc) in kristianstad, sweden. patients aged ≥ 18 years who are suspected of having serious illness but who have no organ-specific symptoms will be referred to the dc for further investigation after preliminary assessment in primary care. the overall purpose of the study is to evaluate whether the dc meets its target time for diagnosing cancer. in addition, we will evaluate secondary issues, such as survival, to determine whether this pilot project merits extension to other parts of southern sweden.

diagnostiskt centrum (dc), sweden's first specialized cancer diagnosis center, was established at kristianstad general hospital in 2012 as a model for reducing the time taken to diagnose cancer in primary care patients with diffuse, non-organ specific symptoms. if it is successful, the dc model could be rolled out to other areas of sweden. this study by the center for primary health care research in malmö, sweden and regionalt cancercentrum syd will investigate whether the dc process reduces the time from (1) the point when the patient first contacts his/her primary care center with symptoms to (2) the point when he/she is informed about his/her diagnosis (of cancer or another disease). this will be achieved by comparison with matched control patients with suspected cancer who will be referred to helsingborg general hospital for further investigation according to existing diagnostic procedures. various outcome measures will be investigated, and patients' experiences of the dc process will be assessed using a tailored questionnaire. in addition, the dc model will be subjected to health economics analysis.

Eligibility criteria:
individuals in two cities in southern sweden (helsingborg and kristianstad) who contact their primary care center because of diffuse, non-organ-specific symptoms inclusion criteria: suspicion of cancer following preliminary investigation in primary care exclusion criteria: (1) age \< 18 years; and (2) inability to fill in the patient questionnaire

Keywords: cancer diagnosis center time to diagnosis survival health economics biomarkers
treatment of tendinosis using the tenjet hydroresection system

Conditions: Tendinopathy; Tendinosis

Summary: treatment of recalcitrant tendinopathy remains a clinical challenge for physicians without a minimally invasive treatment option that can consistently provide patients with a long-term relief from chronic pain and ability to return to function. surgical debridement of degenerative tendon tissue has long been the standard of care to treat degenerative tendon pathology once all conservative or minimally invasive treatment options have failed. ultrasound guided tenotomy is an emerging treatment option with the potential to address the underlying degenerative, diseased tissue, by selectively resecting and removing the tissue in a minimally invasive manner. additionally, with the availability of in-office diagnostic ultrasound imaging, physicians now have an opportunity to evaluate and classify underlying tendon pathology during a clinical exam. this study is to evaluate outcomes in patients presenting with a clinical history of recalcitrant tendinopathy with confirmed diagnosis of degenerative tendinosis using diagnostic ultrasound imaging or mri.


Eligibility criteria:
inclusion criteria: * patient is 18 - 70 years of age * chronic tendon pain ≥ 3 months duration * history and clinical examination consistent with tendinosis * sonographic or mri confirmation of tendinosis * 3 months of conservative treatment * patient is willing and able to provide informed consent and comply with the study protocol exclusion criteria: * full thickness tear of the tendon * unable to withhold anticoagulants 7 days prior to the procedure. * use above 81mg/day of acetylsalicyclic acid (asa) and/or non-steroidal anti-inflammatory drug (nsaid) within 7 days of treatment * steroid, prp, stem cell or biologic injections within 3 months of the study procedure date * needle tenotomy, tenex, or surgical interventions within 6 months of study procedure date * active local or systemic infection requiring antiviral, antibacterial or antifungal treatment * chronic conditions such as crps or fibromyalgia that might affect pain symptoms.
genetic epidemiology of coronary heart disease risk in women twins

Conditions: Cardiovascular Diseases; Coronary Disease; Heart Diseases

Summary: to examine genetic and environmental influences on several recently identified coronary heart disease risk factors in identical and fraternal adult women twins. the risk factors included low density lipoprotein (ldl) subclass patterns, plasma apolipoprotein levels, body fat distribution, and serum insulin levels.

background: in 1974, a twin registry was established from members of the kaiser permanente medical care program's northern california region. in all, 9,821 twin pairs were enrolled. in 1978-1979, 434 pairs of female twins were recruited from the registry for a clinical examination of coronary heart disease risk factors. the clinical examination included an extensive health questionnaire, measurements of plasma lipids and serum chemistries, analyses of genetic markers for determination of zygosity, measurement of expired air carbon monoxide and serum thiocyanate levels, and a complete physical examination. during the ten years since the first examination, several new or more specific coronary heart disease risk factors have been recognized, including low density lipoprotein and insulin levels, and the anatomic distribution of body fat. design narrative: all women who participated in the first examination were invited to participate in the second examination. medical records and/or death certificates were obtained to document coronary heart disease events. questionnaires were used to collect information on health history, nutrition, and physical activity. a clinical examination assessed blood pressure, a variety of anthropometric measures and cardiovascular fitness. blood specimens were collected for clinical chemistry and lipid/lipoprotein profiles. to assess genetic influence, the heritability of each of the risk factors was estimated. blood was frozen for future studies of polymorphic dna markers. using the monozygotic co-twin control method, the effects of environmental or behavioral factors on these risk factors were assessed after controlling for genetic factors that could explain their association. two hypotheses were examined that could be uniquely addressed using twin data. first, the association of body fat distribution with other coronary heart disease risk factors was mediated by serum insulin levels. secondly, cardiovascular fitness explained in part the association of physical activity with coronary heart disease risk factors such as hdl-cholesterol and insulin levels. lipoprotein analyses were conducted at donner laboratory at berkeley. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
determinants of health-related quality of life for patients after renal lithotripsy: pnl versus rirs

Conditions: Health Related Quality of Life

Summary: percutaneous nephrolithotomy (pnl) and retrograde intrarenal surgery (rirs) are well-established procedures for renal stone fragmentation; however, the morbidity, hospitalization, and lost work hours associated with these procedures can negatively affect the health-related quality of life (hrqol) of the patients \[1-3\]. the choice of modality is based on the european association of urology (eau) and/or american urological association (aua) guidelines. however, selecting a modality is challenging, considering the advantages and drawbacks of both modalities. rirs while minimally invasive, has an inferior stone-free rate compared with pnl; however, pnl requires general anesthesia and longer hospitalization \[4\]. the need to select the therapeutic modality for urinary lithotripsy based not only on the stone-free rate but also on the subsequent hrqol of the patient is increasingly recognized \[5\]. the concept of hrqol is multidimensional, which includes psychosocial, physical, and emotional factors, as well as patient autonomy, and is applicable to a wide variety of medical conditions \[6\]. patients with urolithiasis represent an ideal group for the investigation of hrqol, considering the disease's high prevalence, non-life-threatening nature, severe symptoms, and high recurrence rate \[3\]. however, only a few longitudinal studies have investigated hrqol in patients undergoing lithotripsy for urinary calculi \[7\]. several studies have evaluated hrqol using the short-form 36-item survey (sf-36) \[3, 7-9\]. hence, this study aims to compare longitudinal hrqol between pnl and rirs at four timepoints: before surgery (bef), on the day of discharge (0 mo), and 1 month (1 mo) and 6 months (6 mo) after surgical intervention, and to further investigate the factors that may significantly affect the hrqol of these patients

2.4.1- type of the study: prospective randomized clinical study 2.4. 2- study setting: qena university hospital 2.4. 3- study subjects: 1. inclusion criteria: all patients performing pnl or rirs for renal stones 2-4 cm 2. exclusion criteria: patients refuse to participate in this study unfit patients renal stones more than 4 cm renal stones less than 2 cm 3. sample size calculation: not less than 50 patients in each group 2.4.4 -study tools (in detail, e.g., lab methods, instruments, steps, chemicals, ...): * medical history * complete physical examination. * short-form 36-item survey (sf-36) * all patents presented was investigated by 1. abdominal u.s 2. plain x ray 3. non contrast ct 4. serum creatinine 5. urine analysis

Eligibility criteria:
inclusion criteria: * all patients performing pnl or rirs for renal stones 2-4 cm exclusion criteria: * patients refuse to participate in this study unfit patients renal stones more than 4 cm renal stones less than 2 cm

Keywords: quality of life , pcnl , rirs
diclofenac patch for treatment of mild to moderate tendonitis or bursitis

Conditions: Rotator Cuff Tendonitis; Bicipital Tendonitis; Subdeltoid Bursitis of the Shoulder; Subacromial Bursitis of the Shoulder; Medial Epicondylitis of the Elbow; Lateral Epicondylitis of the Elbow; DeQuervain's Tenosynovitis of the Wrist

Summary: the primary purpose of this study is to assess the effectiveness of once daily application of a diclofenac sodium patch to the skin near or over the painful area. in this study, the location being studied will be one of the following: the affected shoulder, elbow, or wrist. the secondary purpose of this study is to assess the safety and tolerability of the diclofenac patch on the subject's skin, in the location being studied.

cerimon pharmaceuticals is investigating a topical patch formulation of diclofenac sodium containing 15 mg of diclofenac sodium for the local treatment of acute musculoskeletal pain.

Eligibility criteria:
inclusion criteria: * 18 years to 75 years of age * onset of painful upper extremity tendonitis or bursitis, no more than 21 days prior to study entry * eligible diagnoses are rotator cuff tendonitis, bicipital tendonitis or subdeltoid/subacromial bursitis of the shoulder, medial or lateral epicondylitis of the elbow, and dequervain's tenosynovitis of the wrist * spontaneous pain with motion or resisted motion and tenderness to palpation over the involved tendon(s), bursa, or epicondyle * presence of pain of at least 5, with a maximum of 9, on an 11-point numerical rating scale (nrs) exclusion criteria: * aspirin, or short half-life nsaid use within 12 hours, or longer half-life nsaid use within 24 hours prior to study entry (see appendix b: for table of nsaids) * opioid use within 3 days prior to study entry * topical treatment, other than local ice or heat, applied to the painful region within 3 days prior to study entry * history of peptic ulcer disease within 1 year prior to study entry, any history of gastrointestinal bleeding, or coagulation disorder * a history of, or evidence for underlying articular disease such as osteoarthritis, rheumatoid arthritis, gout, or pseudogout (calcium pyrophosphate deposition disease) * clinically significant and poorly controlled pulmonary, gastrointestinal, hepatic, renal, endocrine, or cardiovascular disease * a history of hypersensitivity to diclofenac or diclofenac-containing products * a history of intolerance to acetaminophen (rescue medication in this trial) * a history of skin sensitivity to adhesives (e.g. adhesive tape) * pregnant or breastfeeding women and women of child-bearing potential not using effective means of contraception

Keywords: tendonitis bursitis
cognitive-behavioral therapy for children with nightmares as a mediator of suicide risk (comaa)

Conditions: Nightmare

Summary: youth suicide risk has increased 56% in the last decade, and suicide is the leading cause of preventable death in children and adolescents. experiencing chronic nightmares doubles the risk of suicidal ideation in children and adolescents. decades of research support that even when controlling for depression and insomnia, nightmares predict suicidality. contemporary theories model nightmares as the mediating link between depression and suicide. numerous studies examine the effect of nightmare-specific therapies on reducing suicide in adults, but none have examined whether nightmare therapies can reduce youth suicidality. the proposed pilot will evaluate the feasibility of the cognitive behavioral therapy for nightmares in children paradigm (cbt-nc), recruiting and retaining children ages 6-17 who experience chronic nightmares. utilizing a waitlist control (wl) model, participants (n=30) will be randomized after baseline assessment to either immediate treatment or a wl. feasibility will be evaluated by examining retention through treatment (or wl) to post wl and post treatment assessments. both groups will be evaluated before and after the treatment for suicidal ideation, sleep quality, and nightmare distress and frequency, in order to document improvements due to therapy. the proposed pilot will provide preliminary data about recruitment, retention, and allow for effect size calculations between groups. these results will be used to develop a larger treatment study that would ultimately evaluate the mediating effect of treatment for chronic nightmares on suicidality in children.


Eligibility criteria:
inclusion criteria: * child must be between the ages of 6-17 years 11 months. * child must report recurrent nightmares that meet dsm criteria for nightmare disorder. * child must speak and understand english at no less than a 6 year old level. * children on prescribed psychotropic medications must be stable for 30 days prior to enrolling. * child must have a parent or legal guardian attend study visits with them. * participants must have access to wifi/phone data in order to participate in this study, and must have an electronic device with a camera enabled. our study team will have the capability of driving a tablet to the participant's home if that is the only reason they cannot participate, and if the family lives within the greater tulsa area. exclusion criteria: * children with a previous diagnosis of sleep apnea which is not adequately treated. * children whose receptive/expressive language skills are below a 6 year old level. * if it is determined that a child is actively suicidal and at imminent risk for self-harm, the family will be notified and referred for immediate care. they will not be eligible for the study until they are deemed stable.

Keywords: nightmares children trauma cbt exposure relaxation rescripting cognitive behavioral therapy suicidality
the effect of electrotherapy on young individuals with neck pain

Conditions: Neck Pain

Summary: the aim of this clinical study was to investigate the effects of different electrotherapy interventions on pain and hand function in young individuals with neck pain. the main question that the study aimed to answer is: are two different electrotherapy interventions superior to each other for pain and hand function? participants will be assigned to either transcutaneous electrical nerve stimulation, high-voltage pulsed galvanic stimulation, or placebo. participants will receive a total of 20 sessions of electrotherapy intervention, 20 minutes per day, 3 days a week. participants will be evaluated before the intervention, after 1 session, and 1 week after the completion of the 20-session intervention.


Eligibility criteria:
inclusion criteria: * being between 18-30 years old * complaining of neck pain * volunteering to participate in the study exclusion criteria: * having received any anti-inflammatory treatment in the last 3 months * having received any physical therapy and rehabilitation treatment in the last 3 months * doing regular exercise * not attending work sessions

Keywords: neck pain electrotherapy tens hvpgs
communities helping the hearing of infants by reaching parents

Conditions: Congenital Hearing Loss

Summary: hearing loss is the most common sensory congenital disorder and this condition is diagnosable and treatable. children that are born with hearing loss have to undergo several hearing tests to diagnose the condition and many families are delayed in receiving this testing or never obtain the needed testing. this research employs a new method for helping children with hearing loss receive timely care by using a patient navigator, who is someone who teaches and provides emotional/social support for the families of these children. the hypothesis of this study is that a patient navigator will hasten the timing of pediatric audiological testing, improve compliance with scheduled appointments, and expand parental knowledge of pediatric hearing loss.

for specific arm 1: the investigators will (1) use a stepped-wedge trial design to deliver patient navigation (pn) sequentially in 10 state-funded kentucky commission for children with special healthcare needs (ccshcn) (also referred to as the office for children with special healthcare needs or ocshcn) clinics randomized to cross from usual care to pn in steps of 6-month intervals over the project period. prior to initiation of pn at each clinic, the control condition will be the standard of care. the overall effectiveness of pn will be tested by comparing non-adherence rates during the pn condition to those during the standard of care condition. simultaneously, the investigators will (2) assess preliminary implementation outcomes (i.e., acceptability, adoption, recruitment/retention, and fidelity) as well as multilevel factors influencing implementation of pn in each clinic. for specific arm 2: patient navigators will not be used for all subjects at participating clinics.

Eligibility criteria:
inclusion criteria: inclusion criteria for parent-infant dyads: 1. infant failed a hearing screening in one or both ears before postnatal hospital discharge 2. infant was referred for follow-up diagnostic testing at one of the 10 participating ccshcn clinics. 3. parent able to speak either english or another language using cyracom phone interpreting services. exclusion criteria: 1. children and parents live outside kentucky or who will be moving out of kentucky within the first three months of life.

Keywords: infant hearing screening patient navigator
to explore the potential for pf-04531083 to effect the blood concentrations of simvastatin and its main acid metabolite following co-administration of both medications

Conditions: Chronic Pain

Summary: the purpose of this study is to quantify the effect of multiple doses of pf-04531083 on the pharmacokinetics (pk) of co-administered single dose simvastatin.

observational- quantify any effects of pf_04531083 on the pk of simvastatin

Eligibility criteria:
inclusion criteria: * young * healthy * male and female volunteers exclusion criteria: * elderly * patients

Keywords: pharmacokinetics drug-drug interaction