Kornimate/medical-research-clean huggingface dataset:
efficacy of dnk333 in patients with copd and cough

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study evaluates the efficacy and safety of two weeks treatment of dnk333 in patients with copd and cough.


Eligibility criteria:
inclusion criteria: * mild to moderate copd * forced expiratory volume in 1 second (fev1) ≥30% predicted * fev1/fvc (forced vital capacity) \<70% * significant amount of cough and minimal amount of sputum production, both as judged by self reporting exclusion criteria: * upper or lower airway infection within 4 weeks prior to screening * copd exacerbation within 4 weeks prior to screening * past history or current diagnosis of congestive heart failure, cirrhosis or hepatic failure * history of lung cancer or pulmonary resection/thoracic radiotherapy other protocol-defined inclusion/exclusion criteria may apply

Keywords: chronic obstructive pulmonary disease cough dnk333
novel cardiac rehabilitation in patients heart failure and preserved ejection fraction

Conditions: Heart Failure, Diastolic

Summary: patients with hfpef suffer from exercise intolerance, increased risk for hospitalization and mortality, and poor qol. unlike patients with hfref, no drug or device therapies appear to be consistently beneficial in treating these problems. however, increasing evidence suggests that exercise training is effective for both partially reversing exercise intolerance and improving quality of life in these patients. most such trials to date have been conducted in controlled research setting, versus integrating these patients in to a standard cr program. also, since functional capacity is related to outcomes in these patients, exercise strategies aimed at further improving fitness are warranted. one such strategy is using higher intensity interval training (hiit) in the cr setting, a strategy shown to be effective in patients with other types of cvd. this project is designed to test the feasibility of incorporating these patients into the cr setting, and training them using a methodology (i.e., hiit) already shown to yield (in other patients with cvd) greater gains in fitness when compared to what was achieved using standard mct alone.


Eligibility criteria:
inclusion criteria: 1. nyha class ii or iii symptoms 2. referred by physician to cr with echocardiographic evidence of hfpef defined as an ejection fraction ≥ 50 % and moderate to severe (grade ii-iii) diastolic dysfunction. 3. ≥ 50 years of age 4. free of orthopedic or other medical problems that would limit participation in cr 5. peak vo2 on baseline cardiopulmonary exercise test (cpx) \< 24 ml/kg/min in men and \<21 ml/kg/min in women exclusion criteria: 1. systolic dysfunction, per ejection fraction \< 50%; those with mild (grade i) diastolic dysfunction 2. initial clinical responses observed during first 3 visits in cr or baseline exercise test that would preclude participation in study over-all (e.g., new onset/troublesome arrhythmia that warrants further investigation) or undergoing hiit (e.g., claudication, balance issue) 3. patients with exercise induced angina during cr or cpx testing or st segment depression representative of myocardial ischemia during cpx testing 4. pregnant or planning to become pregnant 5. any patient recently hospitalized for heart failure will have to wait at least 2 weeks before starting cr, or until clinically stable per physician(whichever time period is greater) 6. atrial fibrillation
latent tuberculosis in type 2 diabetes

Conditions: Latent Tuberculosis Infection

Summary: the patients with poorly controlled dm underwent ltbi screening by using quantiferon (qft). qft-positivity predictors were evaluated. the patients with ltbi received tuberculosis preventive therapy, 9 months of daily isoniazid (9h) or 3 months of weekly rifapentine plus isoniazid (3hp), administered by pulmonologists. the completion rates and inflammatory markers were also investigated.

poor control of diabetes mellitus (dm) increases active tuberculosis (tb) risk. understanding risk factors for latent tb infection (ltbi) in this population is crucial for policy making. under a collaborative multidisciplinary team consisting of endocrinologists and pulmonologists, patients with poorly controlled dm were enrolled; these patients underwent ltbi screening by using quantiferon (qft). qft-positivity predictors were evaluated. the patients with ltbi received tuberculosis preventive therapy, 9 months of daily isoniazid (9h) or 3 months of weekly rifapentine plus isoniazid (3hp), administered by pulmonologists. the completion rates and inflammatory markers were also investigated.

Eligibility criteria:
inclusion criteria: * aged ≥45 years * poorly controlled dm (pdm), defined as hba1c ≥9% within the preceding year exclusion criteria: * active tb * immunocompromise (use of immunosuppressors * current pregnancy

Keywords: latent tuberculosis infection diabetes observational study
study on vulnerable plaque of carotid artery with chinese herbal and insects medicine

Conditions: Carotid Artery Plaque

Summary: the investigators want treat vulnerable plaque of carotid artery with a herbal and insects chinese medicine. designing a rct trial to prove the effect and safety.

vulnerable plaque of carotid artery is the important intervention target for primary prevention and secondary prevention of cerebral arterial thrombosis, but there are no effective, safe and prevalent treatment measures against it. the development that traditional chinese medicine has achieved in treating plaque of carotid artery shows that great accomplishment could be made within this area. academia should engage in clinical research on regulated treatment methods in traditional chinese medicine with long-term intervention and high patient compliance, providing strong evidence for evidence-based medicine and guidance to clinical practice.

Eligibility criteria:
inclusion criteria: 1. meet the diagnostic criteria of carotid artery atherosclerosis; 2. ultrasound of carotid artery atherosclerosis plaque specifies it as unstable plaque (including malacoplakia and mixed plaque); exclusion criteria: 1. mrs rating higher than or equal to 3 before joining the trail group; 2. carotid artery stenosis is higher than or equal to 50%; 3. confirmed as or suspected to be vasculitis; 4. with infection, tumor or insufficient heart, liver and kidney functions (renal function higher than twice of upper limit in normal limit, hyha heart function grading higher than or equal to level 2 ); 5. with acute myocardial infarction and unstable angina pectoris; 6. with acute cerebral arterial thrombosis; 7. lesion: severe stenosis or occlusion of distal intracranial vessels; 8. pregnant women or lactating mothers; 9. with known history of allergy to the drugs of the trial.

Keywords: herbal medicine stroke vulnerable plaques of carotid artery
sharp versus blunt fascial incision at caesarean section

Conditions: Cesarean Section

Summary: the purpose of this study is to compare sharp and blunt fascial entry during caesarean section on the same patient. the study is performed on woman having cesarean section for the first time and who have not previously had lower abdominal surgery done. the following parameters are registered: 1. the preferred side evaluated by the patient 3 months postoperatively. 2. the patient evaluated difference in pain on the right vs. left side 1, 3 and 7 days and 1 and 3 months postoperatively. 3. the rate and side of infection.


Eligibility criteria:
inclusion criteria: * woman having caesarean section for the first time * woman, who have had no previous lower abdominal surgery * woman who speak and understand danish * woman who can give informed consent exclusion criteria: * diabetes mellitus (this does not include gestational diabetes) * infection * regular treatment with immunosuppressives * alcohol or drug abuse * age under 18 years old * chronic pain disease eg. fibromyalgia, rheumatoid arthritis * bmi over 35

Keywords: cesarean section cesarean section[*methods] fascia [*surgery] randomized controlled trial abdominal wall [*surgery] pain, postoperative surgical wound infection
targeting inflammation for endometrial cancer prevention

Conditions: Endometrial Carcinoma

Summary: this study examines risk assessment and identifies prevention strategies for endometrial cancer. collecting samples of blood and urine and risk assessments from patients with benign conditions or endometrial cancer may help doctors learn if there is a relationship between chronic inflammation and increase in risk for endometrial cancer.

primary objective: i. to develop a model for a biobank that can be expanded across the mayo enterprise and implemented at extramural collaborative sites, including underserved populations. outline: this is an observational study. patients complete a risk factor questionnaire over 15 minutes. patients also undergo collection of blood and urine during pre-operative visit and collection of tissue samples at the time of surgery.

Eligibility criteria:
inclusion criteria: * women over the age of 18 years old undergoing hysterectomy for any benign indication or endometrial cancer exclusion criteria: * men * women under the age of 18 years * women with a history of cancer, except for endometrial cancer or non-melanoma skin cancer * women with type 1 diabetes * women that have received radiation or chemotherapy for cancer
connection between vitamin d level and the efficacy of dexamethasone in immune thrombocytopenia

Conditions: Immune Thrombocytopenia

Summary: the project was undertaking by qilu hospital of shandong university in china. the objective is to find out if there is a connection between vitamin d level and the efficacy of dexamethasone for the treatment of adults with newly-diagnosed primary immune thrombocytopenia (itp).

the investigators anticipate to undertaking a prospective, observational，non-randomized control trial of 60 itp adult patients. dexamethasone (given orally at a dose of 40 mg per day for 4 days, two-cycles with an interval of 10 days) will be used in the target patients. vitamin d level will be detected before the utilization of treatment measures. depend on the vitamin d level, the patients will be divided into 2 groups(higher vitamin d level group and lower vitamin d level group).platelet count, bleeding and other symptoms were evaluated before and after treatment.

Eligibility criteria:
inclusion criteria: corresponding to the diagnostic criteria for immune thrombocytopenia newly diagnosed itp patients to show a platelet count \<30 \* 10\^9/l, and with bleeding manifestations willing and able to sign written informed consent exclusion criteria: received chemotherapy or anticoagulants or other drugs affecting the platelet counts within 3 months before the screening visit; received second-line itp-specific treatments (eg, cyclophosphamide, 6-mercaptopurine, vincristine, vinblastine, etc) within 3 months before the screening visit; received high-dose steroids or ivig in the 3 weeks prior to the start of the study; current hiv infection; severe medical condition (lung, hepatic or renal disorder) other than chronic itp. unstable or uncontrolled disease or condition related to or impacting cardiac function (e.g., unstable angina, congestive heart failure, uncontrolled hypertension or cardiac arrhythmia) female patients who are nursing or pregnant, who may be pregnant, or who contemplate pregnancy during the study period; have a known diagnosis of other autoimmune diseases, established in the medical history and laboratory findings with positive results for the determination of antinuclear antibodies, anti-cardiolipin antibodies, lupus anticoagulant or direct coombs test; patients who are deemed unsuitable for the study by the investigator.
dysphagia and deep cervical flexor muscles

Conditions: Dysphagia; Neurological Disorder

Summary: cervical posture is vital for normal swallowing function. changes in cervical posture during swallowing alter the bolus flow and swallowing kinematics through changes in gravity and oropharyngeal space. the hyoid bone does not articulate with any bone, so it requires adequate tension of the hyolaryngeal complex and proper cervical postural alignment to maintain its stabilization and position. changes in cervical posture and stabilization can cause changes in hyoid bone position and kinematics through muscles and ligaments which may lead to decrease in hyoid elevation, loss of optimal strength of the suprahyoid and infrahyoid muscles due to disrupted length-tension relationship, and an increased risk of aspiration due to insufficient laryngeal elevation. further, deterioration in cervical posture and decreased stabilization resulting from cervical muscle weakness or/both endurance could affect the control and strength of masticatory muscles, tongue muscles and suprahyoid - infrahyoid muscles, which are involved in swallowing function. whereby dcf weakness gives rise to inadequate cervical stabilization, change in hyoid bone stabilization, alterations in suprahyoid and infrahyoid muscle function, and decreased laryngeal elevation may adversely affect the normal function of the swallowing related muscles. thus, decreased cervical stabilization, which is often seen in neurological diseases, may be related to neurogenic dysphagia. given the known changes in cervical stabilization as a consequence of neurologic injury, the additional impact on swallowing or a potentially already neurologically-disordered swallow is considered. thus, loss of cervical stabilization may be one of the factors affecting dysphagia in patients with neurological diseases providing more information on all potential factors contributing to swallow impairment, potentially leading to more targeted and effective swallowing interventions. however, there is no study investigating the role of the dcf muscles in dysphagia. therefore, the aim of the present study was to comparison of deep cervical flexor muscle strength and endurance in patients with and without neurogenic dysphagia.


Eligibility criteria:
inclusion criteria: - diagnosis of neurological disease, age range inclusive of 18-65 years , independent sit-to-stand, prior consultation for dysphagia, and underwent a modified barium swallowing study (mbss). exclusion criteria: * neck pain complaints in the previous 30 days history of cervical surgery and head and neck cancer, cervical pathology involving the neck region such as cervical disc herniation or radiculopathy presence of cervical osteophytes and/or cervical kyphosis detected in the mbss, history of rheumatic diseases.
20-valent pneumococcal conjugate vaccine safety and immunogenicity study of a 3-dose series in healthy infants

Conditions: Pneumococcal Disease

Summary: 20-valent pneumococcal conjugate vaccine safety and immunogenicity study of a 3-dose series in healthy infants


Eligibility criteria:
inclusion criteria: * male or female infants born at \>36 weeks of gestation and 2 months of age at the time of consent. * healthy infants determined by clinical assessment, including medical history and clinical judgment, to be eligible for the study. exclusion criteria: * history of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis). * major known congenital malformation or serious chronic disorder. * other acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the participant inappropriate for entry into this study. * previous vaccination with any licensed or investigational pneumococcal vaccine, or planned receipt through study participation.
motivation and barriers for exercise in patients with anxiety or posttraumatic stress disorder

Conditions: Exercise; Motivation

Summary: relevance and aim: there has been increasing research interest in sport preferences and motivational factors as well as barriers that restrain from engaging in sport activities in people suffering from mental illnesses. anxiety disorders are one of the leading mental disorders worldwide. exercise has previously shown anxiolytic effects and is discussed as an adjunctive treatment option in clinical practice. this study aims to depict motivation and barriers in patients with anxiety or posttraumatic stress disorders. design and participants: observational study of patients diagnosed with anxiety disorder or posttraumatic stress disorder (icd-10) measurements: structured questionnaire compounded of validated scales for current physical activity, sport motivation, exercise preferences, perceived barriers , self-efficacy, social support for physical activity, motivation,enjoyment, quality of life as well as sociodemographic data. duration: the questionnaire will require approximately 20 minutes, the overall duration is 3 months. personal assistance for completing the questionnaire will be provided if necessary.


Eligibility criteria:
inclusion criteria: * in- and out-patients with a diagnosed anxiety or posttraumatic stress disorder (f40, f41, f43.1; icd-10) * 18 to 65 years exclusion criteria: * acute psychosis or suicidal behaviour * cognitive deficits * problems with german language

Keywords: anxiety posttraumatic stress disorder
effects of electronic cigarettes in cigarette smokers with mild to moderate copd

Conditions: COPD; Tobacco Use

Summary: this study evaluates the effects of electronic cigarette use on cigarette smoking and markers of tobacco use, as well as respiratory symptoms and function in smokers with mild to moderate chronic obstructive pulmonary disease (copd). all participants will receive a 12 week supply of electronic cigarettes to use instead of their regular conventional cigarettes.

electronic cigarettes are devices that heat a solution containing nicotine to form an aerosol that is then inhaled by the user. electronic cigarettes are used by many smokers, including smokers with chronic health conditions such as copd. given that e-cigarettes are still relatively new, their effects on health are not well defined. it is important to understand how electronic cigarettes affects symptoms and lung function in smokers with copd to determine the short-term safety of these products. to do this, an initial step involves observing the extent to which smokers substitute their conventional cigarette use with electronic cigarette use and change their exposure to tobacco use biomarkers.

Eligibility criteria:
inclusion criteria: * at least 10 pack year smoking history * daily use of at least 5 cigarettes * no plan to quit cigarettes in the next 30 days * willing to use e-cigarettes * diagnosis of copd (fev1/forced vital capacity \[fvc\] \ 80% predicted) or moderate (fev1 \ 50% predicted) airflow limitation (post-bronchodilator); confirmed by spirometry * english-speaking exclusion criteria: * past 30-day use of nicotine-containing products (cigars, cigarillos, hookah, electronic cigarettes, smokeless tobacco, nicotine replacement therapy) * past 30 day use of inhaled drugs (marijuana, crack) * pregnant or breastfeeding * planning to become pregnant within the next 3 months or unable to agree to use appropriate contraception during study * pulmonary disease other than copd or asthma * ever requiring mechanical ventilation * 2 or more hospitalizations for copd in the past 12 months * cardiac hospitalization in the past 6 months * active chest pain or palpitations * uncontrolled hypertension (blood pressure \>160/100) * oxygen therapy * inability or contraindication to perform spirometry (e.g. recent eye, thoracic, or abdominal surgery) * known allergy to propylene glycol or vegetable glycerin * unable to consent or complete assessments

Keywords: electronic cigarettes; e-cigarettes
evaluation of the effect of a food supplement based on hydrolyzed collagen on joint function.

Conditions: Pain, Acute; Pain, Chronic; Knee Osteoarthritis; Knee Injuries

Summary: this clinical study evaluates the effect of taking a hydrolyzed collagen-based supplement on pain, function and quality of life in a moderately physically active population. non-pathological knee pain is a common occurrence in many healthy people and can limit the quality of life. therefore, the resolution of this problem can bring many benefits in terms of quality of life.

study design randomized, double-blind, placebo-controlled clinical trial with 2 parallel study groups (collagen-based formulation and placebo). participants will take the study products for 12 weeks.

Eligibility criteria:
inclusion criteria: * individuals who exercise regularly and meet the who definition of being moderately active. * persistent exercise-associated knee pain lasting at least 2 months prior to study inclusion. * knee pain score on the visual analogue pain scale of at least 30 mm, taking into account that the scale has a maximum range of 100 mm. exclusion criteria: * individuals with severe illness. * subjects who are taking or have been treated within the last 7 days with glucosamine, chondroitin sulphate, collagen or hyaluronic acid injections or any dietary supplement indicated for joint health. * subjects with chronic inflammatory diseases affecting the musculoskeletal apparatus. * subjects with obesity (bmi ≥ 30 kg/m2). * allergy or known hypersensitivity to any of the ingredients in the investigational product. * phenylketonuria. * treatment with narcotics, steroidal anti-inflammatory drugs or immunosuppressants. - symptoms of extreme pain requiring high doses of analgesic therapy for a period of time longer than 2 weeks or intra-articular injection treatment. * individuals with diabetes. * pregnant women. * lactating women. * subjects who are participating in a clinical trial. * subjects who have participated in a clinical trial for pain in the last month.

Keywords: hydrolyzed collagen post-exercise pain supplementation inflammation quality of life
trans-radial superior rectal artery embolisation for haemorrhoids

Conditions: Hemorrhoids

Summary: endovascular embolisation is already a common procedure for bleeding haemorrhoids in the acute setting, where surgical options are not possible or have been exhausted. this pilot study aims to add to the small body of evidence that transarterial embolisation of symptomatic haemorrhoids is also safe and effective in the elective setting, providing a good alternative to conventional surgical management. this is a day case procedure that is performed under local anaesthetic. for selected patients, this presents a less invasive management option with reduced potential morbidity. for a health care system under significant financial stress, this provides a potential means of cost improvement, the extent of which this study will try and quantify. a series of 20 selected patients will be recruited to undergo this procedure and then followed up for 24 months. the long-term goal of this pilot study is to form the basis of a national registry of such procedures.


Eligibility criteria:
inclusion criteria: patients eligible for the study must comply with all of the following prior to enrolment: * patients with grade ii-iv haemorrhoid disease with re-current or active bleeding * patients with (i) who do not wish to undergo surgery for their symptoms * patients with (i) despite recent surgery * patients willing and able to give fully informed consent * patients aged ≥18 years exclusion criteria: * patients who are not otherwise fit for surgery * patients with significant ano-rectal comorbidities (cancer, fistula, abscesses) * patient who are unable to sign the informed consent form. * patients who are pregnant (completed as part of standard irmer protocol) * patients with history of significant colorectal disease or previous colectomy. * patients with history of an allergic reaction to x-ray contrast * patients who are currently involved in research

Keywords: embolisation