Kornimate/medical-research-clean huggingface dataset:
blood pressure measurement in dialysed patients

Conditions: End Stage Renal Disease

Summary: the objective of the current study is to evaluate the compliance to blood pressure measurements' recommendations in dialysis centers. the idea is to address a questionnaire to physicians, head nurses and patients in order to probe the way to measure blood pressure. the objective is to face the theoretical guideline with what is effectively done.

in dialysis center, blood pressure is measured as well as a vital sign than as a predictor of cardiovascular event. accurate measurement of blood pressure is critical for making appropriate clinical decisions. guidelines have been issued on standard blood pressure measurement procedure for the detection of hypertension and the follow-up of patients with hypertension. in hospital adherence to guidelines is low (manzoli, simonetti et al. 2012). whether these guidelines are followed in dialysis patients is not known. thus it would be of great interest to investigate the bp measurement procedures that are effectively applied in dialysis centers. this project is an international survey across 10 dialysis centers. the current study is conducted on 10 physicians, 10 head nurses and 100 to 200 patients in switzerland, in europe and in the mediterranean basin. the adherence to bp measurement guidelines will be assessed thanks to two questionnaires of 20 items; one addressed to the patients and the other to the medical staff (clinicians and head nurses). the project is scheduled to last a total of 4 months. two months are dedicated to the presentation of the project, the recruitment as well as to the participation of the volunteers, and two months to the analysis. the research project is carried out in accordance to the research plan and with principles enunciated in the current version of the declaration of helsinki (doh), the essentials of good epidemiological practice issued by public health schweiz (egep), the swiss law and swiss regulatory authority's requirements as applicable.

Eligibility criteria:
inclusion criteria: * dialysed patients (hemodialysis or peritoneal dialysis) exclusion criteria: -

Keywords: blood pressure dialysis
respiratory outcome at adolescence of very low birthweight infants

Conditions: Premature Baby 26 to 32 Weeks; Bronchopulmonary Dysplasia

Summary: epipageado is an observational study. respiratory symptoms and lung function will be evaluated in very low birth weight and term infants, born in 1997 and included in the french epipage cohort.

epipageado is a multicenter observational study:- to evaluate respiratory symptoms and lung function at adolescence in very low birthweight (vlbw) children, to identify perinatal risk factors for persistent symptoms or impaired lung function tests at adolescence, to assess the exercise tolerance in vlbw children and to search for genetic susceptibility markers associated to impaired lung function. the main criteria for analysis will be the forced expiratory volume in one seconde (fev1) the study duration will be 36 months the number of centers will be 4 centers in france (paris-necker, nantes, lille, rouen) the number of patients to be included will be 400, including 260 vlbw children without bpd, 40 vlbw children with bpd, 100 control children with birth at term.

Eligibility criteria:
inclusion criteria : * children born in 1997, and included at birth in the french epipage cohort * absence of severe neurologic impairment, with impossibility of reliable lung function tests * acceptance of the child and his/her parents exclusion criteria : * severe neurologic impairment, with impossibility of reliable lung function tests * absence of child's or parents' acceptance

Keywords: low birthweight bronchopulmonary dysplasia lung development airway obstruction asthma
the surgical gastrointestinal diseases registry protocol

Conditions: Gastrointestinal Diseases

Summary: by placing the medical record information of many subjects into a research registry, researchers will be able to conduct research studies directed at increasing our knowledge about gastrointestinal diseases.

researchers are asking for past, current and future medical record information.

Eligibility criteria:
inclusion criteria: * subjects being seen by the university of pittsburgh medical center for gastrointestinal diseases
long-term outcome in congenital undescended testis after surgical treatment by orchidopexy

Conditions: Undescended Testis

Summary: the purpose of this study is to determine the long-term outcome in congenital undescended testis after surgical treatment by orchidopexy and to what extent orchidopexy is the treatment for congenital undescended testis.


Eligibility criteria:
inclusion criteria: * the orchidopexy has taken place in the medical center alkmaar between 1986-2004 * the indication concerned a congenital undescended testis * it concerns a first orchidopexy to the concerning testis exclusion criteria: * orchidopexy has taken place on an other reason than congenital undescended testis (for example: torsio testis) * it concerns re-orchidopexy

Keywords: orchidopexy, long-term outcome, congenital
effectiveness and security testing of a mobile app (b·right) for emotional crisis in borderline personality disorder

Conditions: Borderline Personality Disorder

Summary: to assess the effectiveness and security of a mobile app (beta version) for self-managing emotional crisis in a pragmatic randomized controlled trial with 80 patients with borderline personality disorder (40 patients with treatment as usual, tau) versus 40 patients with tau plus the mobile app)


Eligibility criteria:
inclusion criteria: * dsm-5 (diagnostic and statistical manual of mental disorders, fifth edition) of borderline personalidad disorder (bpd) * aged 18-60 yeats old exclusion criteria: * comorbidity with mental retardation * comorbidity with psychotic disorder * comorbidity with antisocial personality * comorbidity with autism spectrum disorder

Keywords: borderline personality disorder mobile app crisis intervention effectiveness security
efficacy and safety of hypertonic sodium lactate solution compared with 6% hes solution in cabg patients

Conditions: Coronary Heart Disease

Summary: the choice of fluid therapy is controversial in cardiac surgery. numerous studies have shown that colloid is better as compared to crystalloids. several previous studies have demonstrated that hypertonic sodium lactate (hsl) administration during cardiac surgery shows a promising effect. this study aims to compare hemodynamic effects and fluid balance of hsl with 6% hydroxy ethyl starch (hes).

the primary objectives of this prospective, randomized and open-label study are as follows: * to evaluate the clinical efficacy of hypertonic sodium lactate (hsl) in comparison with 6% hes to maintain hemodynamic stability in intra cabg patients related to hemodynamic status and body fluid balance. * to assess the safety of hsl in intra cabg patients related to defined laboratory parameters clinical adverse events which occur during the trial. subjects meeting enrolment criteria will be randomly assigned to hsl or 6%hes treatment groups. assessment of comparability will be done by unpaired student t-test or chi-square test or by a two-way anova for repeated measures followed by post-hoc analysis when significant difference is found within the two groups. the hypothesis tested is that hsl is effective in intra cabg surgery patients, requiring less volume with better cardiac index, as compared to 6% hes.

Eligibility criteria:
inclusion criteria: * male or female, aged 45-80 years. * cabg patients with on or off pump procedure. * ejection fraction \<50% * patients who have given their written informed consent. exclusion criteria: * combined operations(surgeries) * patients with severe arrhythmia (vt, af rapid response, heart block) and severe hemodynamic imbalance. * severe bleeding and/or re-operation. * hypernatremia\> 155 mmol/l * severe liver failure: sgot and sgpt more than twice normal. * severe renal failure: creatinine more than 2 mg%. * patients with major diseases such as cancer, etc.

Keywords: heart disease cardiac surgery cabg totilac voluven 6% hes
socket shield technique versus conventional immediate implant placement in thin buccofacial bone

Conditions: Crestal Bone Loss

Summary: buccal bone is prone to resorb after tooth extraction specially with immediate tooth implantation which could compromise the esthetics of the patient. socket shield technique retains the buccal aspect of the extracted root fragment which may help in preventing the buccal bone from resorbing and prevent esthetics deterioration

the alveolar ridge resorbs and collapses following tooth removal which continues to be a major concern for practitioners. many researchers concluded that buccal aspect of the ridge is more prone to resorption, as it is primarily supplied by the periodontal tissues and ligments of the tooth. therefore, extraction of the hopeless tooth, may be a reason for buccal cortical plate resorbing at a faster rate than the palatal plate leading to its total degradation. this may lead to dimensional changes in the human ridge and the aesthetic area is highly affected by this process. several techniques in the litreture were proposed to solve the problem of thin buccal bone resorption with or without immediate implantation in the aesthetic area. some of these techniques are the guided bone and soft tissue regenraton and bone augmentation but proved to be slight aggressive with high morbidity rate. recently, several papers were published concerning the socket shield technique explaining how to maintain the ridge width and height. socket shield technique that was first introduced in 2010 aids at retaining the buccal fragment of root in place and intact thus placing the implant behind the lingual aspect of that fragment so that the periodontal ligments and tissues preserve its vitality and aids in preventing the collapsing of the buccal bone. this would help in improving aesthetics especially during immediate implant placment in the anterior maxillary region.

Eligibility criteria:
inclusion criteria: * • humans * esthetic area (anterior and first premolars) * intact labial plate * hopeless tooth indicated for extraction and immediate implant placement exclusion criteria: * • implantation after trauma * peri-implantits defects * use of barrier membranes(gbr) * socket preservation

Keywords: socket shield technique crestal bone loss immediate implanation
anti-inflammatory effect of agaricus blazei murill in inflammatory bowel disease (ibd)

Conditions: Ulcerative Colitis; Crohn's Disease; Inflammatory Bowel Disease

Summary: examine whether daily oral ingestion of a immunomodulatory mushroom extract (andosantm) in patients with ulcerative colitis (uc) and crohn's disease (cd), experience clinical, biochemical and genetical improvement in their disease. a prospective randomised study comparing the mushroom extract with placebo.


Eligibility criteria:
inclusion criteria: * moderate disease exclusion criteria: * serious disease, * biological treatment, * pregnancy.

Keywords: cytokine levels in blood calprotectin in feces clinical symptom score.
danish multicenter scapholunate ligament study

Conditions: Ligament Injury; Wrist Sprain

Summary: comparison of two surgical techniques commonly used for reconstruction of the scapholunate (sl) ligament. a randomized multicenter study.

this multicentre study aim to compare two surgical techniques commonly used for reconstruction of the scapholunate (sl) ligament. the investigators compare patient reported, clinical and radiological outcomes up to 10 years after treatment of complete dynamic or static but reducible sl ligament lesions. the participants are randomized to two treatments. effect parameters before and after intervention are compared between groups.

Eligibility criteria:
inclusion criteria: * age 18-60 years (both included). * symptomatic sl instability (vas score ³3, qdash score ³ 20). * \> 6 weeks since symptomatic hand trauma (chronic sl lesions). * sl gapping on radiographic stress views or sl gapping (³2mm) on static pa views. * complete sl ligament lesion confirmed by wrist arthroscopy exclusion criteria: * geissler grade 1-3 sll injury (evaluated by arthroscopy). * concomitant complete luno-triquetral (lt) ligament injury (evaluated by arthroscopy). * lesion of tfcc leading to druj instability (evaluated by arthroscopy). * radiocarpal or midcarpal arthritis evaluated by arthroscopy. * previous fracture in carpus or intraarticular radius fracture with step off (³2 mm), disposing to posttraumatic arthritis. * adverse effects after extra articular radial fractures (dorsal angulation ³10 grader). * peroperatively non-reducible scaphoid flexion/sl gap. * terminal illness or severe medical illness: asa score higher than or equal to 3.
a study of omp-305b83 in subjects with metastatic colorectal cancer

Conditions: Metastatic Colorectal Cancer

Summary: the purpose of this study is to test the safety and efficacy of an experimental drug, omp-305b83, when given in combination with folfiri or folfox. omp-305b83 is a humanized bispecific monoclonal antibody and was developed to target cancer stem cells. based on preclinical studies, it is believed that omp-305b83 may block the growth of cancer stem cells and may also impair the productive growth of new blood vessels, which tumors need to grow and spread. the study is sponsored by oncomed pharmaceuticals, which is referred to as oncomed or the sponsor.

this is an open-label, phase 1b dose escalation and expansion study of omp-305b83 plus folfiri or folfox to evaluate the safety, efficacy, and pharmacokinetics of omp-305b83 in combination with folfiri or folfox in patients with metastatic colorectal cancer. this study consists of a screening period, a treatment period, and a post-treatment follow-up period in which patients will be followed for survival for up to 5 years. patients will be enrolled in two stages: a dose-escalation stage and an expansion phase.

Eligibility criteria:
inclusion criteria: * measurable disease per response evaluation criteria in solid tumors (recist) v1.1 * age \>21 years * eastern cooperative oncology group (ecog) performance status of 0 or 1 * adequate organ and marrow function * for women of childbearing potential and men with partners of childbearing potential, agreement (by patient and/or partner) to use two effective forms of contraception from study entry through at least 6 months after the termination visit. * ability to understand and the willingness to sign a written informed consent document exclusion criteria: * receiving any other investigational agents or any other anti-cancer therapy * receiving prior hepatic intra-arterial chemotherapy * known significant clinically significant gastrointestinal disease * patients with brain metastases (treated or untreated) leptomeningeal disease, uncontrolled seizure disorder, or active neurologic disease * significant intercurrent illness that will limit the patient's ability to participate in the study or may result in their death over the next 18 months * pregnant or nursing women * inability to comply with study and follow up procedure
short-term caregiver psychotherapy

Conditions: Caregiver Burden of People With Dementia

Summary: this study is to test the feasibility (pilot part) and efficacy (phase iia part) of a specifically on the needs of caregivers of people with dementia composed new short-term psychotherapeutical intervention.

this prospective study will be offered to caregivers from the out patient clinic of the department of psychosomatic medicine of the university rostock medical center. in a first pilot study with 10 participants without control group, we tested the feasability and acceptance of the program (completed 2/2015). from 4/2015 a phase iia study started with 10 participants in the intervention group and 10 in the control groups (will be organized by waiting list). the program consists of two modules of caregiver education followed by ten psychotherapeutic group modules. duration of each module is planned to be 90 minutes including a relaxation exercise at the end of each module. primary outcomes are the feasibility, acceptance and the effect on caregiver burden.

Eligibility criteria:
inclusion criteria: * caregiver of a person with dementia * willing to participate in all 12 modules of the program exclusion criteria: * current psychotherapy or antidepressive medication for less than 6 month * major depression

Keywords: caregiver burden stress depression dementia
observational study of outcomes in cystic fibrosis patients with selected gating mutations on a cftr allele (the vocal study)

Conditions: Cystic Fibrosis

Summary: to describe the effectiveness of kalydeco® treatment in patients with cystic fibrosis (cf) who have 1 of 8 non g551d gating cftr mutations (g178r, s549n, s549r, g551s, g1244e, s1251n, s1255p, or g1349d).


Eligibility criteria:
inclusion criteria: * male or female with confirmed diagnosis of cf16 * at least 1 allele with 1 of the following cftr mutations: g178r, s549n, s549r, g551s, g1244e, s1251n, s1255p, g1349d * six years of age or older on the date of signed (informed consent form) icf, and where appropriate, date of assent * signed icfs and, where appropriate, signed assent form * able to understand the study requirements and comply with study data collection procedures exclusion criteria: * previously exposed to kalydeco, except currently treated patients who started kalydeco treatment within 6 months of enrollment * currently enrolled in a kalydeco interventional study or other interventional therapeutic clinical study directed at cftr modulation * history of organ transplantation

Keywords: cystic fibrosis
the effect of red blood cells transfusion in trauma patients

Conditions: Trauma

Summary: we will evaluate the effect of red blood cell (rbc) transfusion on fatal and non fatal events according to baseline risk of death in an international cohort of trauma patients (crash-2 trial). the following outcomes will be considered: death from all causes, death due to bleeding, death due to multiorgan failure, death due to vascular occlusive events and non vascular occlusive events. non fatal outcomes include: myocardial infarction, stroke, deep vein thrombosis and pulmonary embolism.

aims: primary objective: evaluate the effect of rbc transfusion on all cause mortality according to baseline risk of death due to bleeding. secondary objectives: evaluate the effect of rbc transfusion on specific causes of death. evaluate the effect of rbc transfusion on non fatal vascular occlusive events. sample: patients from the clinical randomisation of an antiﬁbrinolytic in signiﬁcant haemorrhage (crash-2) trial. the trial included 20,127 trauma patients with, or at risk of, significant bleeding, within 8 hours of injury, and was undertaken in 274 hospitals in 40 countries. outcomes: death from all causes, death due to bleeding, death due to multiorgan failure, death due to vascular occlusive events and non vascular occlusive events. vascular occlusive events include: myocardial infarction, stroke, deep vein thrombosis and pulmonary embolism. all events were measured at 28 days or hospital discharge interventions and comparisons: we will compare the effect of red cells transfusion versus no red cells transfusion. we will also evaluate the effect of the number of units of red cells transfusion. methods: we will stratify patients according to baseline risk of death from all causes into four strata (\ 50%). we will then evaluate the effect of rbc transfusion according to baseline risk on fatal and non fatal outcomes. formal statistical test to detect heterogeneity will be conducted analyzing baseline risk as a continuous variable.

Eligibility criteria:
inclusion criteria: * patients eligible for inclusion in the trial were "adult trauma patients with ongoing significant haemorrhage, within 8 hours of injury." exclusion criteria:
pre-therapeutic validation of the virtual reality-based exposure scenario for cbt "revbed" for the induction of food craving in patients with bulimia and binge eating disorder (bed)

Conditions: Bulimia Nervosa; Binge-Eating Disorder

Summary: food craving is a major therapeutic issue in eating disorders with binge eating: the bulimia nervosa and the binge eating disorder (bed). food craving is linked to compulsive eating and its apprehension is currently based on classic cognitive and behavioural therapies (cbt). however, it remains difficult to induce in therapy and a significant number of patients do not respond to classic cbts. the development of exposure scenarios for cbt in virtual reality (vr) has allowed a gain in efficacy and in particular therapeutic effects lasting longer after treatment. nevertheless, the stimuli used are often simple food visuals and insufficiently consider the many factors influencing food craving (physical, psychological, socio-environmental...) and vr immersion is still limited by the use of 3d laptops (fixed) rather than wireless headsets.

eating disorders-specialized clinicians from saint-etienne university hospital center (chu) and vr-specialized engineers from national school of engineering of saint-etienne (enise) therefore collaborated in the creation of revbed, a vr-based exposure scenario for cbt for the induction of food craving in eating disorders with binge eating. revbed offers successive exposures to multimodal stimuli in a coherent scenario and in an immersive virtual environment via a wireless vr headset. our first objective is to validate the effectiveness of our scenario in inducing food craving in patients with bulimia and bed.

Eligibility criteria:
inclusion criteria: * patients: who meet diagnostic and statistical manual of mental disorders (dsm)-5 criteria for bulimia nervosa or binge eating disorder * controls: paired to patients on age and level of education exclusion criteria: * patients and controls: * under legal protection measure (guardianship, curatorship or safeguard of justice) * having a treatment being established and / or not stabilized (declarative) able to alter the physiological data recorded and the answers to the self-questionnaires * having one or more sensory deficit(s) or disorder(s) incompatible with the use of vr equipment (declarative) * patients: who have already benefited from specific care targeting food craving (declarative) controls: with a score greater than or equal to 88 on the bulimia test (bulit)

Keywords: food craving virtual reality eating disorders bulimia nervosa binge eating disorder