Kornimate/medical-research-clean huggingface dataset:
predictors of driving performance and successful mobility - rehabilitation in patients with medical eye condition

Conditions: Low Vision

Summary: there are two diseases in particular that may have serious consequences for driving and mobility due to their potentially severe impact on visual function: glaucoma and diabetic neuropathy. in this project we will develop predictive models of driving for these patients and will train them to use low-vision aids to improve driving mobility. we will determine how best to train patients with hemianopic field loss due to cerebral vascular accidents and identify predictors of long-term success in the use of low-vision aids.

there are two diseases in particular that may have serious consequences for driving and mobility due to their potentially severe impact on visual function: glaucoma and diabetic neuropathy. both these diseases can potentially result in significant peripheral visual field loss, sometimes coupled with decreased visual acuity. we have previously demonstrated that each of these visual losses alone can have significant impact on driving and mobility performance. in this project we will develop predictive models of driving for these patients and apply our extensive expertise in training patients to use low-vision aids to improve driving mobility. a second question that will be addressed is how to best train scanning patients with hemianopic field loss due to cerebral vascular accidents. we propose to configure the prisms in a bioptic form similar to previously used for amorphic lenses in rp and for bioptic telescopes for patients in macular disease. the third problem that will be addressed is the identification of predictors of long-term success in the use of low-vision aids.

Eligibility criteria:
eye impairment

Keywords: low vision, driving rehabilitation
implementation of a very low calorie diet for remission of type 2 diabetes in the community

Conditions: Diabetes Mellitus Type 2 in Obese

Summary: the complications associated with uncontrolled type-2 diabetes mellitus (t2dm) are numerous; reducing the quality of life for the patient and consuming a considerable portion of healthcare finances. the health of the nation (hotn) 2011 study reported that 50% of the barbadian population \>65years old had a diagnosis of t2dm and that two-thirds of the population were overweight - which is a risk factor for the development of t2dm. encouraged by the success of the counterpoint study in the united kingdom (uk), the barbados diabetes reversal study 1 (bdrs1) was established using a similar protocol; the aim of which was to evaluate the feasibility of implementing a very low calorie diet to reverse t2dm in barbados. at the end of the 8-week intervention period, the 25 participants had achieved an average weight loss of 10.1kg (22lbs). this was accompanied by an increase in the number of participants whose fasting blood sugars were now within normal range despite being off of their diabetes medication; and a decrease in the number of participants taking blood pressure medication. participants transitioned to a solid diet over a 4-week period, with guidance on health dietary habits and regular exercise routines. the benefits accrued during the intervention phase were preserved at the end of the transition period. we now propose the barbados diabetes remission study 2 (bdrs2) as a sustainable community intervention - utilizing the local church as the community site. we hypothesize that this will enhance reach while reducing the cost of the study and will also facilitate the structures necessary for the social support of the participant.


Eligibility criteria:
inclusion criteria: * adults aged 20 - 70 years old, all ethnicities * diagnosis of t2dm for \<6 years as defined by the american diabetes association * diagnosis of pre-diabetes as defined by the american diabetes association * body mass index (bmi) of 27 kg/m2 and over exclusion criteria: * insulin use * substance abuse * current cancer diagnosis * myocardial infarction within last 6 month * learning difficulties * current treatment with anti-obesity drugs * diagnosed eating disorder or purging * hba1c \> 10% * pregnant/considering pregnancy * evidence of liver disease (including liver enzymes \> 3 times above normal values) * evidence of renal disease (creatinine of \> 150 mmol/l) * persons who have required hospitalisation for depression, or are on antipsychotic drugs

Keywords: diabetes mellitus remission prediabetic state caloric restriction weight loss diet barbados
researching resiliency in stressful experiences (rise) program for men leaving incarceration

Conditions: Stress Disorders, Traumatic; Stress Disorders, Traumatic, Acute; Depressive Symptoms; Anxiety; Substance Use; Aggression; Coping Skills; Impulsive Behavior; Housing Problems; Recidivism; Stress; Occupational Stress; Psychological Distress

Summary: the investigators are conducting a randomized controlled trial to assess the impact of resiliency in stressful experiences (rise) - a comprehensive trauma-based program for young men releasing from a southeastern state's prisons. the investigators are assessing whether treating trauma and providing other transitional supports - such as employment assistance - as young men return home will help to improve their community stability and enhance their psychological well-being, in turn, resulting in less likelihood that a person will become incarcerated in the future.


Eligibility criteria:
inclusion criteria: * males * ages 18-35 * have experienced at least one lifetime traumatic event * released from incarceration to suwanee, leon, duval or columbia county, florida. * conversational in english * being able to cognitively consent exclusion criteria: * younger than 18 years old * older than 35 years old * has not experienced at least one lifetime traumatic event * not cognitively able to understand * not conversational in english * not releasing from incarceration to suwanee, leon, duval or columbia county, florida.

Keywords: employment stability housing stability reentry trauma psychological wel-being
clinical study of balloon pulmonary angioplasty for patients with chronic thromboembolic pulmonary hypertension

Conditions: Chronic Thromboembolic Pulmonary Hypertension

Summary: chronic thromboembolic pulmonary hypertension (cteph) is the fourth group of pulmonary hypertension (ph) according to clinical classification. pulmonary endarterectomy（pea) is the preferred treatment for patients with cteph, however, pea has its limitations, it only applies to the thrombi in the main, lobar, or segmental pulmonary arteries for patients with cteph, and the postoperative residual ph is found to be of high percentage. with the development of interventional techniques, balloon pulmonary angioplasty (bpa) has been used to treat chronic thrombotic pulmonary hypertension (cteph) with favorable results and has been identified as an effective and safe treatment for technically inoperable cteph. balloon pulmonary angioplasty (bpa) has been accepted as a therapeutic strategy in accordance with the 2015 esc/esr guidelines, especially for patients with technically inoperable, an unfavorable risk-to-benefit ratio of the pea. this study was a single-center prospective study that collects 3 time points data (before bpa, after final bpa, and follow-up ) to verify long-term safety and efficacy of bpa, as well as comparing the efficacy with targeted medical therapy, evaluating the complications of bpa, the survival of patients, and the postoperative quality of life.


Eligibility criteria:
inclusion criteria: * technically inoperable for pea in patients with cteph * unfavorable risk/benefit ratio for pea * residual or recurrent ph after pea * aged over 18 years old exclusion criteria: * other groups of ph except for cteph * severe renal insufficiency(egfr\<30ml/min·1.73mˆ2) * severe infectious diseases * severe hemorrhagic tendency * severe anaphylaxis of contrast * pregnancy and lactation * expected survival time is less than half a year due to tumor or other disease

Keywords: balloon pulmonary angioplasty(bpa) chronic thromboembolic pulmonary hypertension(cteph)
observational, non-interventional, non comparative real life data collection of depo-eligard® 7.5 mg, 22.5 mg and 45 mg in male prostate cancer patients

Conditions: Prostate Cancer

Summary: tremodi is an observational, non-interventional, prospective, open-label, non-comparative study that will collect real life data of a treatment with depo-eligard® in 3 different administrations in male prostate cancer patients. once the examining physician has decided on the therapeutic approach and if the selection criteria are fulfilled, he will propose the patient to participate in the study. an informed consent form will be collected for all participants in the study. there are 2 possible study visits that coincide with a routine consultation, namely visit 1 (inclusion visit) and visit 2 (end of study visit). on both visits, adverse drug reactions (adverse event caused by depo-eligard®) are collected and the patient will be asked to complete a quality of life questionnaire (eortc qlq-c30). at visit 2, the examining physician will give a global evaluation of the treatment with depo-eligard® and assesses the treatment benefit of the patient. testosterone and prostate specific antigen (psa) blood values are collected during both visits, if available.


Eligibility criteria:
inclusion criteria: * patients having been prescribed depo-eligard® 7.5 mg - 22.5 mg - 45 mg in accordance with the terms of the marketing authorization.

Keywords: prostate cancer phase 4 data collection observational depo-eligard prospective non-interventional treatment
total body irradiation treatments for patients treated at european institute of oncology

Conditions: Leukemia; Leukemia, Chronic; Leukemia, Acute; Lymphoma; Aplastic Anemia

Summary: patients eligible undergoing total body irradiation as candidates for bone marrow or peripheral stem cell transplant.

total body irradiation (tbi) is an oncological radiotherapy technique that has been used for several decades in patients undergoing bone marrow or peripheral stem cell transplantation. the role of tbi is: to suppress the recipient's immune system to prevent rejection of the donor's bone marrow, whether familial or non-familial. to eradicate residual neoplastic cells following chemotherapy treatments. tbi is typically employed in both neoplastic and non-neoplastic disorders affecting blood cell elements (e.g., acute and chronic leukemias, aplastic anemia, lymphomas, etc.), as well as other conditions such as neuroblastoma, ewing's tumor, and pediatric sarcomas with a poor prognosis. treatment choice is usually established following multidisciplinary discussions, based on disease characteristics and stage, concurrent pathologies and pharmacological treatments, patient preferences, and functional aspects. data collection related to radiotherapy plays a crucial role in understanding various clinical aspects of the treatment itself. the availability of data from an increasing number of patients will allow the identification of clinical situations or technical parameters of radiotherapy correlated with treatment tolerance and effectiveness, aiming to identify the best treatment for these oncological pathologies. this project aims to collect data related to total body irradiation treatments for scientific dissemination with the goal of establishing the basis for evaluating achieved results over time and deriving from these elements useful for guiding the most effective treatment strategies and appropriate operational protocols.

Eligibility criteria:
inclusion criteria: 1. patients undergoing total body irradiation as candidates for bone marrow or peripheral stem cell transplantation. 2. signed informed consent exclusion criteria: * patients who do not undergo total body irradiation
vestibular rehabilitation and balance training after traumatic brain injury

Conditions: Traumatic Brain Injury; Brain Concussion; Head Injury; Dizziness

Summary: the main aim of this study is to evaluate the effect of vestibular rehabilitation and balance training on patients with dizziness and balance problems after traumatic brain injury.

8 000 to 10 000 persons are admitted to hospitals in norway with traumatic brain injury (tbi)annually. dizziness and balance problems have an incidence of 30-80% in this population. studies show that dizziness and imbalance has the potential to restrict several aspects of personal and social life. vestibular rehabilitation (vr) is an accepted and effective treatment for dizziness and imbalance. however there is lack of evidence/knowledge about its effect on tbi patients. the study is designed as a randomized controlled trial study (rct). patients aged 16-60 admitted to oslo university hospital with tbi and symptoms of dizziness and imbalance are included 8 weeks after the injury. the intervention and control group will receive multidisciplinary assessment and evaluation. the intervention group will in addition receive group training and a home exercise program by physiotherapists. the intervention will consist of a individually adapted vestibular rehabilitation and balance program. the main outcome measurement is the dizziness handicap inventory (dhi). the study has several other self-report and performance based outcome measures. the outcome measures will be performed before and after the intervention and 6 months after the injury.

Eligibility criteria:
inclusion criteria: * tbi patients enrolled at oslo university hospital. * persistent dizziness and/or balance problems 2 months post-injury. * functionally and cognitively able to attend a group training program with vestibular rehabilitation and balance training as the main focus. exclusion criteria: * severe psychiatric disorder, * language problems, * cognitive dysfunction that makes self-report difficult, * extremity injuries, * not being able to walk.

Keywords: traumatic brain injury dizziness vestibular rehabilitation balance rehabilitation
correction of refractive error surprises after cataract surgery in adults

Conditions: Refractive Errors

Summary: a refractive surprise can be defined as the failure to achieve the intended postoperative refractive target or the presentation of unexpected and, unwanted post-operative refractive error. it can cause anisometropia or dominance switch and is a source of patient dissatisfaction due to unmet expectations.the best way to manage refractive surprise is to prevent it. the 2017 nice guidelines on the management of cataracts provide advice on prevention of refractive surprise through accurate biometry, a-constant optimisation, intraocular lens (iol) formula selection and avoiding wrong lens implant errors.benchmark standards for nhs cataract surgery dictate that 85% of eyes should be within 1 dioptre (d) and 55% within 0.5d of target spherical equivalent refraction following surgery.

aim(s) of the research: 1. detection of refractive surprises using autorefractometer, and corneal topography. 2. treatment of the resulting refractive error surprises.

Eligibility criteria:
inclusion criteria: all adult patients scheduled for cataract surgery with: * symptomatizing patients with postoperative spherical error of more than 1 diopters. * symptomatizing patients with postoperative cylindrical error of more than 1 diopters. * symptomatizing patients with uncorrected distant visual acuity less than 6/24 * symptomatizing patients with corrected distant visual acuity of less than 6/12 * clear cornea. 6. uneventful surgery. exclusion criteria: * patients with complicated cataract. * raised intraocular pressure (iop). * patients with pathologies of the posterior segment of the eye. * other causes of diminution of vision.

Keywords: refractive error surprises
assessment of inspiratory profiles through airflow resistances designed to mimic inhalers

Conditions: Healthy

Summary: it is hypothesized that different inhalation profiles (inhalation flow rate versus time curves) result from different forms of patient training. furthermore, significant inter-subject variability in these profiles should exist that can, under some circumstances, depend on the design of different inhalation devices; this is because dry powder inhalers have different airflow resistances. the investigators also hypothesize that the spread of flow rate versus time profiles for inhalation can be collected. finally, these profiles can be analyzed from a group of human subjects and used to define a mean and statistical range of inhalation flow rate versus time curves. the investigators propose to collect the inhalation profiles from 20 'inhaler naïve' healthy volunteers after they have (a) read a typical inhaler package insert and (b) been formally trained in inhaler use by a pharmacist. no drug exposure will occur. the data will be used from this pilot study to (a) show the inter-subject variability in the inhalation profiles used by adults inhaling through realistic airflow resistances (like those in inhalers) following different types of training (b) show how formal training changes inhalation technique and (c) provide a database of typical inspiratory profiles for use and improvement of realistic tests of inhalers in the laboratory. since pulmonary deposition from inhalers greatly depends upon the way patients inhale through them, this research will result in a database to improve the design and in vitro characterization of inhalers.


Eligibility criteria:
* must be healthy as determined by a health questionnaire * must not be currently pregnant (self reported) * must not have symptoms of an obstructive or restrictive lung disease or be suffering from allergies or congestion at the time of testing * must have forced 'expiratory volume in one second' \>'lower limit of normal' predicted * must be medically stable with no evidence of acute medical or psychiatric illness, * must have never used or been trained to use a dry powder inhaler, * must not be currently using any inhaler, nasal spray or drug known to affect lung function, bronchodilators and decongestants in any form are excluded * must be at least 4 feet 10 inch tall, * must weigh at least 110 pounds (50 kilograms) and be no more than 264 pounds (120 kilograms) * must not currently, or in the past year, have used tobacco products
additional effect of subthreshold micropulse laser to intravitreous injection of bevacizumab on diabetic macular edema

Conditions: Diabetic Macular Edema

Summary: in this study, all eyes with diabetic macular edema who meet the inclusion criteria and do not meet the exclusion criteria will be included. after the eye examination, the eyes will be randomly divided into 2 groups {group a: intravitreal interjection of bevacizumab and subthreshold micropulse laser, and group b: intravitreal injection of bevacizumab alone}. for both groups, 3 intravitreal injections of bevacizumab with a dose of 1.25 mg will be performed, in sterile conditions at 1-month intervals as a loading dose. a subthreshold micropulse laser will be performed after the third injection in group a and a sham laser will be performed after the third injection in group b. then, the intravitreal injection of bevacizumab will be continued if the central thickness of the macula is equal to or greater than 300 microns. the follow-up will be performed 2, 3, 4, 6, 8, 10, and 12 months after the first injection. in each follow-up (except for the first month), ophthalmological examinations and optical coherence tomography will be performed.


Eligibility criteria:
inclusion criteria: * \> 18 years diabetic patients * center-involved diabetic macular edema * mean central subfield thickness \>300 micrometers * best-corrected visual acuity between 20/40 and 20/400 exclusion criteria: * hemoglobin a1c \> 8 * high-risk proliferative diabetic retinopathy * prior treatment with intravitreal or peribulbar injections within the preceding 3 months * history of panretinal photocoagulation within the former 4 months * history of macular photocoagulation * hx of intraocular surgery (except cataract extraction) * cataract extraction less than 6 months ago * macular edema due to a cause other than diabetic retinopathy * any other ocular condition that visual acuity would not improve from the resolution of the edema (eg, foveal atrophy) * substantial cataract estimated to have reduced visual acuity by \>3 lines * uveitis, neovascular glaucoma, exudative age-related macular degeneration, high risk proliferative diabetic retinopathy * vitreomacular traction or epiretinal membrane * uncontrolled glaucoma ( \> 30 millimeters of mercury with anti-glaucoma medications) * not having: media clarity, pupillary dilation, and subject cooperation sufficient for adequate fundus photographs
comparison of a segnet-based algorithm estimating epifascial fibrosis

Conditions: Lymphedema

Summary: to approval for detecting lymphedema fibrosis before its progression, verification of ct-based quantification of suprafascial microscopic fibrosis has been tried.

in lymphedema, proinflammatory cytokine-mediated progressive cascades always occur, leading to macroscopic fibrosis. however, no methods are practically available for measuring lymphedema-induced fibrosis before its deterioration. technically, ct can visualize fibrosis in superficial and deep locations. for standardized measurement, verification of deep learning (dl)-based recognition was performed. a cross-sectional, observational cohort trial was conducted at a teaching university hospital. the protocol of this study was approved by the university hospital institutional review board and was registered at the protocol registration and results system (prs), www. clini caltr ials. gov (nct04811677: https:// clini caltr ials. gov/ ct2/ show/ nct04 811677? term= nct04 81167 7\& draw= 2\& rank=1). all methods were performed in accordance with the relevant guidelines and regulations. the trial conformed to the tenets of the declaration of helsinki. patients were included if they were clinically diagnosed with unilateral limb lymphedema and had undergone bei analysis and ct scanning. the subjects provided written informed consent for publication of the case details. data were collected as close to the ct scanning date as possible. patients who were diagnosed with deep vein thrombosis, bilateral limb involvement, vascular disease, or local infection were excluded. after narrowing window width of the absorptive values in ct images, segnet-based semantic segmentation model of every pixel into 5 classes (air, skin, muscle/water, fat, and fibrosis) was trained (65%), validated (15%), and tested (20%). then, 4 indices were formulated and compared with the standardized circumference difference ratio (scdr) and bioelectrical impedance (bei) results. in total, 2138 ct images of 27 chronic unilateral lymphedema patients were analyzed.

Eligibility criteria:
inclusion criteria: * the patients who were clinically diagnosed with unilateral limb lymphedema and who underwent multi-frequency bio-electric impedance (bei) analysis and ct scanning. exclusion criteria: * the patients who were diagnosed with deep vein thrombosis, bilateral limbs involvement, vascular diseases or local infection were excluded.