Kornimate/medical-research-clean huggingface dataset:
lifemel efficacy in preventing haematopoietic toxicity in patients treated with chemotherapy

Conditions: Neutropenia; Adverse Event

Summary: leo trial was designed to assess the benefit of administering lifemel to prevent myelotoxicity in patients affected by solid neoplasm undergoing antiblastic chemotherapy treatment at low to moderate risk of febrile neutropenia. secondary endpoints of leo trial were assessing impact of lifemel in preventing anaemia and thrombocytopenia.

the leo trial was designed to assess the benefit of administering lifemel, a honey from bees obtained using zuf globus ltd technology, produced in israel and listed by the ministry of health in italy as a food supplement. this study aims to highlight a possible role of lifemel in preventing neutropenic events, as well as reducing anaemia and thrombocytopenia following the administration of chemotherapy in patients with a histological or clinical diagnosis of solid neoplasia undergoing first-line chemotherapy.

Eligibility criteria:
inclusion criteria: * age \>=18 years old * histological or clinical diagnosis of solid neoplasia * indication for chemotherapy treatment with regimens at moderate risk of neutropenia fever - duration of chemotherapy treatment more than 3 months exclusion criteria: * known intolerances to honey containing compounds * decompensated diabetes or severe glucose intolerance * diseases or therapies significantly affecting the neutrophil count * concurrent use of g-csf as primary or secondary prophylaxis in the study
straw phonation exercise program for pitch extension

Conditions: Voice Fatigue; Voice Disorders; Voice Hoarseness

Summary: to investigate the change in fundamental frequency range and vocal fold stability achievable with vocal fold stretching exercise in human populations with high and low vocal activity

the vocal ligament is part of the layered structure of the vocal fold. it is a thin band of tissue near the superior medial edge of the vocal fold. the cord-like appearance of the ligament gave rise to the traditional term "vocal cord". the ligament connects the arytenoid cartilage (lower broad dark region) to the anterior portion of the thyroid cartilage (upper dark region). the slightly thickened endpoints are known as the anterior and posterior macula flava. in the medial-lateral direction, the vocal ligament comprises the intermediate and deep layer of the lamina propria. the physiological functions of the vocal ligament are not fully understood. one function is to limit mechanical strain (elongation), a general function of most ligaments in the body. a second function may be to produce a firm closure of the glottis by forming a straight edge along the membranous (vibrating) portion of the vocal fold. a strong ligament that can be tensed with exercise is likely to help straighten the edge of the folds. vocal fold bowing, for example, is a pathological condition often associated with advanced age, but it can also occur in young adults who press their arytenoid cartilages together excessively in speech. atrophy of the thyroarytenoid muscle, which lies lateral to the ligament, causes the middle of the membranous vocal fold to be retracted from the midline of the glottis. the result is a weak voice because airflow cannot be suddenly shut off for efficient acoustic excitation of the vocal tract. for self-sustained vocal fold vibration, the superficial layer must be very pliable and deformable for mucosal surface-wave motion. the role of the ligament is then to stabilize the vertical motion when large pressures are applied to vocal fold surfaces. the most important known function of the ligament, however, is to widen the fundamental frequency range. the stiffer the ligament, the greater the likelihood that several octaves of fo range can be achieved.

Eligibility criteria:
inclusion criteria: * participants must be 18 years or older * no current voice disorder * no history of performance or professional vocal training exclusion criteria: * history of head/neck cancer, laryngeal surgery, current voice disorder requiring medical management * cognitive limitations that would prevent them from successfully and safely participating in the study. * history of gastrointestinal disease or surgery w * no known neurological or structural abnormalities of vocal folds * previous laryngeal surgeries; * allergies to local anesthetics (used to suppress a sensitive gag reflex during laryngeal endoscopic examination); * cardiac abnormalities; * recent history of smoking (must be completely smoke-free for six months prior to study commencement because of the effect of smoking on the voice and laryngopharyngeal reflux severity).
psoriatic arthritis d2p screening

Conditions: Psoriatic Arthritis

Summary: the overarching goal of this study is to develop a direct-to-patient screening approach that will improve early psoriatic arthritis (psa) detection in patients with psoriasis. previously developed screening questionnaires were intended for use in the setting of a doctor's office to assist providers with referral decisions. however, these screening questionnaires are infrequently used in routine practice because of limitations with time and resources. the study will aim to develop a practical screening strategy that does not require involvement from dermatologists (or other non-rheumatology providers) and can systematically reach a broad range of psoriasis patients, including patients not attending dermatology clinics. the researchers hypothesize that disseminating questionnaires directly to patients outside of a clinic setting (direct-to-patient approach) will educate patients about their psa risk and improve early psa diagnoses.

electronic medical record (emr) systems will be used to identify psoriasis patients without a psa diagnosis. patients will be randomized to receive a psa screening questionnaire (intervention group) or not receive a questionnaire (control group). rates of rheumatologic evaluations and new psa diagnoses will be compared between the groups, using emrs to longitudinally track outcomes. intervention group patients who through the completion of the psa screening questionnaire positively self-screen for an elevated psa risk will either be randomly invited to directly access a rheumatology appointment or instructed to talk with their doctor about a rheumatology referral. we will compare rates of rheumatologic evaluations and new psa diagnoses between these groups to identify the best method for accessing rheumatology appointments. to determine if psa patients diagnosed after receiving a screening questionnaire differ from patients diagnosed via usual care; investigators will examine disease duration, severity, and comorbidities in patients receiving and not receiving the screening questionnaire.

Eligibility criteria:
inclusion criteria: * have an international classification of diseases (icd) code diagnosis of psoriasis but without a confirmed diagnosis of psoriatic arthritis prior to study initiation * be age 18 or older * be geographically located within a reasonable proximity to the rheumatology study site exclusion criteria: * have psoriasis and a confirmed diagnosis of psoriatic arthritis made or confirmed by a rheumatologist

Keywords: psoriasis
appalachians together restoring the eating environment: improving healthy diet in rural appalachian kentucky

Conditions: Feeding Behavior; Drinking Behavior

Summary: most of the nation's serious chronic health challenges and causes of death, including diabetes, heart disease, cancer, and obesity, are directly linked to sub-optimal diet. both poor diets and associated disease are disproportionately common in the appalachian counties of eastern kentucky, a region with stark health inequities, including elevated rates of obesity, overweight, and premature mortality. the purpose of this study is to evaluate a multi-component intervention developed through community-based participatory research methods for improving access to healthy foods and enhancing dietary intake in eastern kentucky. the intervention components evaluated in this study consist of: 1) a school-based campaign to promote water consumption in middle and high schools and 2) a series of group cooking classes for adults.


Eligibility criteria:
inclusion criteria: * for school-based component: student in selected middle or high school classroom in a participating school in intervention or comparison counties (6th to 12th grades) * for cooking classes: adult aged 18 years or older and residing in intervention county who have at least one dependent child attending middle or high school in the participating school districts exclusion criteria: * unable to speak or read english, as all materials will be presented in english
feasibility study of laparoendoscopic single site surgical staging for endometrial cancer

Conditions: Endometrial Cancer

Summary: to compare the feasibility, safety, and efficacy between single-port and four-port laparoscopic surgical staging in patients with early stage endometrial cancer.


Eligibility criteria:
inclusion criteria: * previously untreated, histologically confirmed endometrial cancer * presumed figo stage 1 * endometrioid adenocarcinoma * patient who is planned to undergo surgical staging * adequate oran function 1. wbc \> 3000 cells/mcl 2. platelets \> 100000/mcl 3. creatinine \< 2.0 mg/dl 4. bilirubin \< 1.5 \* normal and sgot or sgpt \< 3 \* normal * american society of anesthesiologists physical status i-ii * eastern cooperative oncology group performance status 0-2 * patients who have signed an approved informed consent exclusion criteria: * uncontrolled medical disease * active infectious disease requiring antibiotics * previous pelvic radiation therapy * pregnant and lactating woman * patient who requires additional surgical procedures which are not necessary for surgical staging of endometrial cancer

Keywords: endometrial cancer laparoscopic surgical staging single-port four-port
the barcode 1 pilot study

Conditions: Prostate Cancer

Summary: barcode 1 is a screening study designed to investigate the role of genetic profiling for targeting population prostate cancer screening. this study forms a pilot of 300 men, with the view to continue to a future study of 5000 men.

the barcode 1 study aims to evaluate genetic profiling using the known 170 prostate cancer (prca) risk single-nucleotide polymorphisms (snps) as a means of offering targeted screening for prca in men at a genetically higher risk. initially, 300 men will be recruited via participating general practices (gps). men aged 55-69 years who are likely to be eligible for the study will be identified by gps from medical records. participants will be contacted via invitation letters from gps and if interested in the study will be asked to fill in a questionnaire to confirm eligibility to participate. this questionnaire can be completed in hard copy and men will also be given the option to fill in an online version. if eligible, men will then be sent a dna collection saliva kit. dna from saliva will be analysed with snp profiling for the known 170 clinically relevant snps. men with a genetic risk equivalent to the top 10% of the population distribution (approximately 30 men in total) will be invited for a transrectal ultrasound (trus) prostate biopsy, plus further biological samples. biopsy results will be correlated with the genetic score. prostate-specific antigen (psa) and other biomarkers will be integrated into results to assess combined effects of genetic score and markers.

Eligibility criteria:
inclusion criteria: * men aged 55-69 years * caucasian ethnicity * world health organisation (who) performance status 0-2 * absence of any psychological, familial, sociological or geographical situation potentially hampering compliance with the study protocol and follow-up schedule exclusion criteria: * non-caucasian ethnicity (including mixed race or jewish) * previous diagnosis of cancer with a life-expectancy of less than five years * prostate biopsy in the past year * previous diagnosis of prostate cancer * co-morbidities making prostate biopsy risk unacceptable (anticoagulants or antiplatelet medication like warfarin or clopidogrel, poorly controlled diabetes or cardiovascular disease)
comparative effects of radial and focused extracorporeal shock-wave therapies in coccydynia

Conditions: Coccyx Injury

Summary: comparison of the efficacy of coccydynia treatment with two different probes of the eswt device


Eligibility criteria:
inclusion criteria: * clinical diagnosis of coccydynia by clinical examination and x-ray imaging. * be aged ≥18 at the time of diagnosis * be give informed consent exclusion criteria: * malignancy * those who have received eswt treatment before * pediatric patients * patients with infection.
exercise and oscillatory positive expiratory pressure therapy in cystic fibrosis

Conditions: Cystic Fibrosis

Summary: the investigators aim to compare a single bout of moderately intense cycling exercise incorporating flutter® breathing maneuvers with a single bout of moderately intense cycling exercise alone on sputum viscoelasticity (primary endpoint) and the diffusion capacity of the lungs in adult patients with cystic fibrosis. the investigators further aim to analyze the short-term variability of resting diffusion capacity of carbon monoxide (dlco) and nitric oxide (dlno) in patients with cystic fibrosis.

regular airway clearance is an integral component of cystic fibrosis care and of critical importance to lung health. exercise and standardized chest physiotherapy are accepted airway clearance techniques in cystic fibrosis. different airway clearance techniques are available, but there is no evidence that one technique or a combination is superior. oscillatory positive expiratory pressure with the flutter® is a widely used airway clearance technique in the european countries and has been shown to favourably alter sputum viscoelasticity in cystic fibrosis. this randomized crossover study is designed to assess the acute effects of combined cycling exercise and flutter® therapy on sputum viscoelasticity (primary outcome measure) and gas diffusion in adults with cystic fibrosis.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of cf based on either two cf-causing mutations and/or a sweat chloride concentration during two tests of \> 60 mmol/l * patients that are able to provide sputum samples * adult age ≥ 18 years exclusion criteria: * unstable condition affecting participation in the exercise experiments (i.e., major hemoptysis or pneumothorax within the last 3 months, acute exacerbation and iv-antibiotics during the last 4 weeks, unstable allergic bronchopulmonary aspergillosis, listed for lung transplantation, major musculoskeletal injuries such as fractures or sprains during the last 2 months, others according to the impression of the doctor) * cardiac arrhythmias with exercise * requiring additional oxygen with exercise * colonization with burkholderia cenocepacia * status post lung transplantation

Keywords: exercise lung diffusion capacity sputum viscoelasticity lung disease
the dipod study (diagnosis improvement of pneumonia by organ dysfunction)

Conditions: Pneumonia, Ventilator-Associated

Summary: the place of analysis of organ dysfunction in relation to the diagnosis of nosocomial pneumonia in intensive care is not yet defined.

new onset of pulmonary infiltrates, fever, and an increase in white blood cell (wbc) count accompanied by purulent tracheal secretions are clinically indicative of hospital-associated pneumonia (hap). the low specificity and sensibility of diagnostic tests for hap, however, tends to result in an extremely high incidence of missed diagnoses and may lay to high mortality. the place of analysis of organ dysfunction in relation to the diagnosis of nosocomial pneumonia in intensive care is not yet defined, because early organ dysfunction may be the first symptoms noted by clinicians.

Eligibility criteria:
inclusion criteria: patients after cardiac/thoracic surgery with suspicion of hap defined by the presence of the following criteria: * new onset of pulmonary infiltrates, * fever \>38,3°c, * increase in white blood cell (wbc) count * purulent tracheal secretions * but also: * increased use of catecholamine, * need of volemic expansion, * depletion inability, * confusion, * hepatic perturbation with increased gamma-glutamyl transpeptidase (ggt)\>2n or alkaline phosphatase (alp) \>1.5 n, or bilirubin \>1.5n, or aminotransferase (ast or alt\>2 n). exclusion criteria: * child, * pregnancy, * end of life.

Keywords: organ dysfunction scores pneumonia, ventilator-associated intensive care units
nph and regular insulin in the treatment of inpatient hyperglycemia: comparison of 3 basal-bolus regimens

Conditions: Diabetes Mellitus; Hyperglycemia

Summary: the objective of this study is to compare the therapeutic efficacy of three regimens of insulin nph/fast for optimal glycemic control in non-critical hospitalized patients.

patients will be randomly assigned to one of the three treatment regimens. also, the use of oral antidiabetic drugs would be suspended during their stay at the hospital.

Eligibility criteria:
inclusion criteria: * admitted to medical services * persistent blood glucose level \> 140 mg/dl * with an expected stay ≥ 48 hours exclusion criteria: * subjects with type 1 diabetes mellitus * parenteral nutrition * glucose levels ≥ 400 mg/dl at screening * diabetic ketoacidosis or non-ketosis hyperosmolar state * clinically relevant hepatic disease * glomerular filtration rate ≤ 30 ml/min * pregnancy * terminal disease * inability to provide informed consent

Keywords: diabetes mellitus hospital hyperglycemia
mailed fit outreach 2022

Conditions: Colorectal Cancer; Colon Cancer

Summary: this project aims to evaluate different approaches to increase colorectal cancer screening among primary care patients at penn medicine through a centralized screening outreach program. in a pragmatic trial, we will evaluate different approaches to increase response rate to mailed fecal immunochemical test (fit) kits among eligible patients, including differentiated packaging, sending text reminders, and personalized reminders.

while colonoscopy procedures are recommended by guidelines for early detection of colorectal cancer, colonoscopy access remains limited due to delays in screening due to the pandemic and capacity issues. in this project, we will evaluate different ways of reaching out to eligible patients to encourage them to participate in colorectal cancer screening using fecal immunochemical testing (fit). in a mailed fit outreach campaign, we will compare user friendly packaging, text messaging, and personalized reminders to standard outreach with the goal of increasing colorectal cancer screening uptake.

Eligibility criteria:
inclusion criteria: 1. patients ages 50-74 with penn as preferred lab 2. followed by primary care with a participating penn medicine pcp listed and at least one visit in the last 2 years 3. not up to date on colorectal cancer screening per health maintenance (no colonoscopy in the last 10 years, stool testing in the last year, flexible sigmoidoscopy in the last 5 years, fit-dna in the last 3 years). exclusion criteria: 1. personal or significant family history of crc, colonic polyps, hereditary nonpolyposis colorectal cancer syndrome, familial adenomatous polyposis syndrome, other gastrointestinal cancer, gastrointestinal bleeding, iron-deficiency anemia, or inflammatory bowel disease 2. history of total colectomy, dementia or metastatic cancer 3. currently on hospice or receiving palliative care 4. uninsured or self-pay patients 5. currently scheduled for a colonoscopy or sigmoidoscopy

Keywords: prevention cancer screening mailed fit
computerized exercise training for cognitive remediation in adults with multiple sclerosis treated with gilenya

Conditions: Multiple Sclerosis; Cognitive Deficits; Gilenya Modifying Therapy for MS

Summary: this study is investigating the efficacy of computer-based cognitive exercises as a means of cognitive remediation in patients with multiple sclerosis (ms) who are beginning the disease modifying pharmacotherapy gileyna.

gilenya represents the most recent advance in ms disease-modification therapy (dmt) and shows promise for neuroprotection, a feature relevant to the progressive neurologic damage associated with the disease. cognitive impairment accompanies ms in 40-60% of cases and when present, additional symptomatic treatment combined with dmt is required. to date no symptomatic pharmacologic therapy has shown a consistent benefit on ms associated cognitive dysfunction. however, non-pharmacologic approaches show promise. with recent technical and scientific advances, cognitive training is rapidly evolving to become the most effective intervention for the cognitive impairments associated with a wide range of neurological conditions. however, these training programs have not yet been studied in ms. this study will be a randomized open-label clinical pilot trial to compare a plasticity-based and adaptive cognitive remediation (pacr) program to an active control (ordinary computer games) in 20 adults with multiple sclerosis (ms) starting gilenya therapy. primary outcome measures will be used as preliminary indicators of effect, with improvements on program task-related measures and changes in cognitive measures. secondary outcome measures will determine the feasibility of the use of these programs in patients with ms, as indicated by compliance and patient-reported experience.

Eligibility criteria:
inclusion criteria: * ages 18-70 * relapsing remitting ms diagnosis \[81\] * initiating gilenya therapy, or current gilenya therapy (kept constant for the past one month) * no relapse or steroids in previous month * reading score on wrat-3 of 37 or greater * visual, auditory and motor capacity to operate computer software, as judged by treating neurologist or study staff. exclusion criteria: * previous trial of gilenya therapy * history of mental retardation, pervasive developmental disorder or other neurological condition associated with cognitive impairment * primary psychiatric disorder or unstable medical disorder that would influence ability to participate * history of computer-based training with procedures similar to those proposed * learned english language after 12 years of age * unable to comply with study procedures

Keywords: multiple sclerosis cognition cognitive remediation gilenya computerized cognitive exercise
golgi protein for hcc diagnosis

Conditions: Screening for Hepatocellular Carcinoma

Summary: this case-control study was conducted on 90 patients who were equally divided into two groups. group 1 included 45 patients with hcv-related chronic liver disease without clinical or radiological evidence of hcc (control group), and group 2 included 45 patients diagnosed to have hcc by triphasic abdominal ct (patient group). serum afp and gp73 were measured using elisa technique


Eligibility criteria:
inclusion criteria: * patients were older than 18 years. exclusion criteria: * patients with hepatic focal lesions not due to hcc such as hemangioma, hepatic cyst, and liver metastases; patients infected with hiv; patients with any autoimmune disease; or patients with metastatic disease.