Kornimate/medical-research-clean huggingface dataset:
effect of irbesartan on insulin sensitivity in chronic heart failure

Conditions: Chronic Heart Failure

Summary: to test whether treatment with the angiotensin ii receptor antagonist irbesartan improves insulin sensitivity and metabolic profile in patients with chronic heart failure.

in chf impaired insulin sensitivity is a common finding characterised by elevated fasting insulin levels and impaired effectiveness of insulin to utilise glucose in peripheral tissues, mainly in skeletal muscle tissue. additionally, impaired insulin sensitivity, i.e. insulin resistance, progresses in parallel to severity of chf and relates to major clinical symptoms such as reduced exercise capacity and muscle fatigue. in survival analyses, insulin resistance is a significant predictor of mortality, independently of and additionally to other established prognostic markers such as age, nyha class, peak oxygen consumption, or lvef. these findings indicate that insulin resistance is involved in chf pathophysiology. importantly, insulin resistance in chf occurs independently of ischemic etiology. in ischaemic heart disease, however, insulin resistance as part of the metabolic syndrome is also an important prerequisite for the development of arteriosclerosis. accordingly insulin resistance was found worst in chf patients with ischemic etiology compared to patients with chf due to dilated cardiomyopathy and those with ischaemic heart disease without heart failure. on the basis of these findings we hypothesise that therapeutically improving insulin sensitivity may have additional beneficial effects on energy utilisation and therefore improve clinical symptoms such as reduced exercise capacity and muscle fatigue.

Eligibility criteria:
inclusion criteria: 1. ambulatory patients with symptomatic chronic heart failure (nahy ii-iv) 2. ischemic etiology 3. lvef ≤ 45% 4. standard medical treatment for chf (such as diuretics, beta blockers, ace inhibitors, aspirin or warfarin). patients should be treated with aci inhibitor for at least 12 months prior to enrolment into the study. patients should not be treated with angiotensin ii receptor antagonists during the study other than the trial medication. further medical treatment such as spironolactone, amiodarone and others are allowed if the patient is on a stable dose at the beginning of the trial. dosages should be kept stable during the trial except adjustment is judged necessary for clinical reason. 5. patient should be hospitalised due to deterioration of the cardiac disease at least once in the last 12 months under ace-i therapy. 6. age \> 21 years 7. informed consent exclusion criteria: 1. hospitalisation with intervention within 2 weeks of intended randomisation 2. unstable ihd or myocardial infarction \< 2 months 3. open diagnosed diabetes mellitus / antidiabetic treatment with insulin, metformin, sulfonylurea, glinides 4. copd treated with steroids

Keywords: insulin sensitivity chronic heart failure metabolism
mri as alternative to cbct for the assessment of furcation involvement in molars

Conditions: Periodontitis; Periodontal Diseases; Furcation Defects

Summary: aim of this prospective study is to compare magnetic resonance imaging (mri) and cone beam computed tomography (cbct) to diagnose furcation involvement (fi) in molars in patients with periodontitis. the focus is on the differentiation of grad ii and iii according to hamp et al. 1975. 140 molars (70 upper and 70 lower) will be investigated with cbct and mri. due to the absence of ionic radiation mri might be a radiation free diagnostic tool to assess fi in the future without harmful radiation for the patient. patients of the dental clinic, medical university of vienna, who need a cbct and have a clinically diagnosed fi can be a participant of this clinical trial and do in addition to their cbct a mri. the accuracy of mri will be compared to the diagnostic gold standard cbct. if patients need additional periodontal treatment, e.g., periodontal surgery, a subgroup will also be analysed with intraoperative measurements.


Eligibility criteria:
inclusion criteria: * patients with fi grade ii or iii, patients who need a cbct, not pregnant exclusion criteria: * patients with contraindications to perform a mri

Keywords: cbct mri furcation involvement
prophylactic anticoagulation for preventing deep vein thrombosis after total hip arthroplasty

Conditions: Deep Vein Thrombosis

Summary: deep vein thrombosis (dvt) remains a life-threatening complication of arthroplasty. it remains controversial for anticoagulation strategies after total hip arthroplasty (tha). a randomized double-blind study was conducted to determine whether prophylactic anticoagulation was efficient reduce dvt after tha. subjects who underwent uncemented tha were assigned to prophylactic anticoagulation group or non- prophylactic anticoagulation group. patients were followed up 3 months later after surgery. dvt was tested by contrast venography. investigator also used logistic regression analysis with variable selection for obtaining the prediction model of dvt. dvt after tha was affected by personal (age) and clinical factors (mechanical compression, duration of surgery). tha with short duration of surgery did not require prophylactic anticoagulation.


Eligibility criteria:
inclusion criteria: * primary total hip arthroplasty exclusion criteria: * revision hip replacement, total knee replacement, revision knee replacement, semi-hip replacement and cemented thr were excluded. * coagulation related disease and cancer were excluded either.

Keywords: deep vein thrombosis total hip arthroplasty prophylactic anticoagulation randomized study
intraperitoneal carbon dioxide concentration measurement during standard laparoscopy with a new airseal access port

Conditions: Laparoscopic Carbon Dioxide Measurement

Summary: the new airseal access port for laparoscopic surgery does not use a mechanical valve on the port to maintain gas in the peritoneal cavity. it uses an invisible barrier created by high flow gas jets within the port. the percentage of carbon dioxide, the standard gas used for laparoscopy, during laparoscopic surgery has not been previously measured, but is probably high. the investigators aim to measure the percentage of intraperitoneal carbon dioxide with standard ports and the airseal port during a variety of conditions during laparoscopic procedures including suturing and suctioning. the study period will commence at the start of the operation, and be completed upon discharge from the hospital or postoperative day 5, whichever is shorter. all devices are approved for use in humans by the fda, and are being used for their intended purpose.

the surgiquest airseal system is approved by the food and drug administration (fda) as access port for laparoscopic surgery that utilizes an invisible air curtain rather than a mechanical barrier to maintain pneumoperitoneum. in addition to the cannula, there is special filtration tubing and an air pump that act in concert with an existing co2 insufflator. the system has been approved for use and purchase at baystate medical center by the value analysis committee. despite fda approval and extensive laboratory testing, there is still no human data regarding intraperitoneal co2 levels under a variety of conditions one would normally experience during a laparoscopic operation. the specific aim of this study is to measure these levels during laparoscopic cases in humans. we hypothesize that there will be no more than minimal alteration of intraperitoneal co2 levels when using the airseal system when compared to the standard laparoscopic system. the follow-up to this is examining evidence of extraperitoneal gas extravasation. this will occur as part of routine post-operative care, but we will be collecting data, that will be de-identified in the post-operative period.

Eligibility criteria:
inclusion criteria: * all patients undergoing a laparoscopic operation exclusion criteria: * pregnancy

Keywords: laparoscopy airseal carbon dioxide insufflation pneumoperitoneum
technology-based symptom monitoring intervention for locally advanced head and neck cancer patients

Conditions: Head and Neck Cancer

Summary: the goal of this observational study is to assess the satisfaction and usability of an interactive and patient-centered mobile application (app), oleena™, designed to assist head and neck cancer patients undergoing chemoradiation in managing common and distressing symptoms in real-time, as well as to assess the satisfaction and usability of the related hcp web portal. additional secondary usage and clinical endpoints that would be used to assess intervention efficacy in future trials will be collected.


Eligibility criteria:
inclusion criteria: * ≥18 years old * planned to initiate chemoradiation for locally advanced head and neck cancer at moffitt cancer center * ecog performance status ≤2 * able to speak and read us english or spanish * able to provide informed consent * owns a smartphone with an ios or android operating systemcompatible with oleena * able to access the internet * willing to use a mobile app for symptom management exclusion criteria: * documented or observable psychiatric or neurological disorders that would interfere with study participation (e.g., psychosis, active substance abuse). * a prior cancer diagnosis except for non-melanoma skin cancer. * currently enrolled in an industry-sponsored clinical trial. * pregnant women. * patients undergoing re-irradiation * patients who meet the inclusion criteria may be excluded at investigator's discretion
a novel laparoscopic hepatectomy posture, left lateral position plus jackknife position

Conditions: Hepatocellular Carcinoma

Summary: since the first report of laparoscopic resection of a benign hepatic tumor by professor h. reith in 1991, the laparoscope has been widely used in liver disease. based on its advantages in laparoscopic vision and amplification, laparoscopic hepatectomy (lh) has been well recognized globally. generally speaking, for lesions located in the left, front or lower part of the liver, corresponding to couinaud segments ii, iii, ivb, v and vi, an lh surgery is recommended; however, for lesions located in segments vii and viii, the surgery is high technically difficult due to poor exposure. therefore,the investigators employ the left lateral position plus jackknife position to better expose lesions in these segments, hoping to reduce surgical time and bleeding in lh.


Eligibility criteria:
inclusion criteria: 1. patients were diagnosed with hepatocellular carcinoma (hcc) based on the criteria established by the european association for the study of the liver 2. tumor located in segment vi, vii, or viii. exclusion criteria: 1. major vessel or bile duct tumor invasion, 2. recurrent hcc 3. tumor close to secondary vessels and bile ducts 4. patients with extrahepatic metastasis 5. grade c liver function, 6. significant surgical contraindications
comparative performance of purevision lens designs

Conditions: Myopia

Summary: the objective of this study is to evaluate the performance of the purevision lens designs when worn on a 30-day continuous wear basis


Eligibility criteria:
inclusion criteria: * subject is myopic * va correctable to 0.3 logmar or better (driving vision) * clear central cornea exclusion criteria: * systemic disease affecting ocular health * using systemic or topical medications * wear monovision, multifocal or toric contact lenses * any grade 2 or greater slit lamp findings
effect of diode laser activated irrigation versus ultrasonic on post-operative pain in single visit of necrotic teeth

Conditions: Necrosis

Summary: the investigator intended to study the effect of laser versus ultrasonic in activation of irrigation in post operative pain of patients have a symptomatic necrotic teeth

the investigator will choose from patients entering clinic of endodontics in faculty of oral and dental medicine cairo university who are eligible to the criteria. after the patients is found eligible,the patients will be randomly assigned to either the control (ultrasonic activated irrigation )or to the intervention ( diode laser activated irrigation) treatment done in both in single visit. at the end of treatment, patients will be asked to record post operative pain by nrs .

Eligibility criteria:
inclusion criteria: * asymptomatic necrotic single rooted single canal teeth with or without chronic periradicular lesion. * teeth with mature root * teeth without calcified root canals * teeth without root caries * teeth without internal or external root resorption * teeth with no sign of crack formation * teeth without anatomic abnormalities exclusion criteria: * pregnant or lactating females * teeth with vital pulp * non- restorable teeth * medically compromised patients * patients with facial swelling or acute infection. * previously endodontically treated teeth * periodontally affected teeth

Keywords: diode laser asymptomatic pulp laser activated irrigation continuous ultrasonic activation post obturation pain
postprandial triglyceride impact on coronary atherosclerosis in non-diabetic patient in sohag university hospital

Conditions: Coronary Atheroscleroses

Summary: introduction cardiovascular diseases, including coronary artery disease (cad), are the leading cause of mortality worldwide. despite remarkable advancements in diagnostic and therapeutic approaches, cad continues to pose formidable challenges. atherosclerosis, characterized by the deposition of lipids, inflammatory cells, and fibrous tissue within the arterial walls, is the fundamental pathology underpinning cad. atherosclerosis development and progression are closely intertwined with lipid metabolism, particularly elevated levels of low-density lipoprotein cholesterol (ldl-c) and reduced levels of high-density lipoprotein cholesterol (hdl-c) \*1+. however, emerging evidence suggests that postprandial triglyceride levels, the transient increase in triglycerides following a meal, may play a pivotal role in atherosclerotic processes \*2+. postprandial hypertriglyceridemia has been linked to various cardiovascular risk factors, including inflammation, endothelial dysfunction, oxidative stress, and altered hemostasis \*3+. cardiovascular disease (cvd) causes death for 4 million subjects in europe every year. it causes death for women \*2.2 million (55%)+ than men \*1.8 million (45%)+, and cardiovascular (cv) deaths under 65 years more prevalent in men (490 000 versus 193 000) \*4+. endothelial dysfunction was the main cause of vascular atherosclerosis. the damage of endothelium cause lipids and macrophages accumulation (mostly lowdensity lipoprotein) in vessel injury site \*5+. lipids considered the major cause of atherosclerosis \*6+. the increase of blood cholesterol (especially ldl) considered the main cause of the disease. high levels of triglycerides could be independent risk factor for coronary artery disease (cad), particularly in women. although, it was suggested that high level of density lipoproteins (hdls) can prohibit these risk factors. extensive examinations showed that lipid decrease the prevention of cad in primary and secondary cases \*7+. the level \> 90% of total glyceride and/or ldl and level \> 10% of hdl confirm dyslipidemia \*8+


Eligibility criteria:
inclusion criteria includes cad based on coronary angiography, laboratory and ecg evidence. exclusion criteria: patients with other co-morbidities diseases, such as liver and kidney disorders and thyroid diseases. diabetic patients.
mind-body program for cancer patients

Conditions: Neoplasms

Summary: the purpose of this study is to find out if mind-body groups can help improve the physical and emotional well-being of people facing cancer or its treatment.

pain, fatigue, anxiety, depression, nausea, sexual impairment, body image disturbance, relationship strains, existential distress and role losses are all potential "side-effects" of living with cancer and its treatment. behavioral interventions have shown some success in mitigating distress and qol impairment among cancer patients. the purpose of this randomized-controlled study is to compare the effects of mind-body group interventions on the quality of life of patients with advanced cancer. patients are randomized to one of two psychotherapy groups, which occur weekly for eight weeks. quality of life assessments are conducted at baseline and two and four-month intervals.

Eligibility criteria:
inclusion criteria: * on active treatment for: breast cancer stage iv, colorectal cancer stage iv, lung cancer stages iii \& iv, or all other cancers (any stage on treatment) * language is english or spanish exclusion criteria: * patient is currently attending other support/psychotherapy group * significant cognitive impairment * ecog performance status = 3 or 4 * current major untreated psychiatric disorder * unable to attend intervention in following 8 weeks due to medical or practical restrictions

Keywords: neoplasms needs assessment adaptation psychological minority groups psychotherapy, group program evaluation spirituality spiritual therapies
vaginal microbiome transplantation for recurrent bacterial vaginosis

Conditions: Bacterial Vaginoses

Summary: vaginal microbiome transplantation (vmt) may be beneficial in treating the most severe cases of recurrent and antibiotics-nonresponsive cases of bv. recently, we completed a preliminary study in which we treated patients with recurrent and antibiotics-non-responsive, intractable bv, with vmt from healthy donors \[lev-sagie, nature medicine 2019\]. four vmt recipients in this preliminary study featured a significant improvement of both clinical symptoms and dysbiotic vaginal microbiome composition and function, which persisted over a long follow-up period, while one recipient featured a partial remission. the proposed study is designed as a placebo, randomized controlled trial, and is aimed to further assess whether vmt may serve as a viable option in symptomatic, intractable bv. in the suggested study, we plan to compare transplantation of: 1) vaginal fluid from healthy donors, and 2) autologous transplantation, of the patient's own vaginal fluid.


Eligibility criteria:
inclusion criteria: * ages 18-50 * recurrent bv, defined as ≥4 symptomatic episodes of bv during the last year, who require maintenance antibiotic treatment (twice weekly) in order to remain symptom-free, or if they experienced recurrence of bv in ≤ 2 months following antibiotic treatment, with a documented history of recurrent bv in the last year. * patients are otherwise healthy. * contraception use exclusion criteria: * pregnancy or a planned pregnancy in the upcoming year * infection with hiv. * immunodeficiency status.
efficacy and safety study of osi-211 (liposomal lurtotecan) to treat recurrent small cell lung cancer

Conditions: SCLC; Carcinoma, Small Cell

Summary: the purpose of this study is to determine whether osi-211 (liposomal lurtotecan) is an effective and safe treatment for patients with recurrent small cell lung cancer.


Eligibility criteria:
inclusion criteria: * confirmed recurrent small cell lung cancer. * one prior treatment of chemotherapy. * at least three weeks since last chemotherapy treatment and recovery from any related side effects. * at least three weeks since last chest radiotherapy and at least 10 days since head irradiation and recovery from acute side effects. * at least one target tumor less than or equal to 20 mm (or less than or equal to 10 mm on spiral ct-scan). * if a patient has had previous documented central nervous system (cns) involvement, only controlled disease is acceptable. exclusion criteria: * superior vena cava syndrome.

Keywords: small cell lung cancer
evaluation of the influence of short term fasting diet on chemotherapy-induced toxicities in breast cancer patients

Conditions: Fasting, Diet, Chemotherapy, Toxicity

Summary: this is a clinical trial aiming to assess the effect of fasting diet on chemotherapy - induced toxicities in breast cancer patients. the study will have an intevention group and a control group. the intervention group will follow a fasting diet of 60 hours (36h prior chemotherapy and 24h after the end of chemotherary), while the control group will follow regular (standard) diet. at the meantime of the chemotherapy cycles, the intervention group will be recommended to follow the mediterranean diet. the main questions this study is aiming to answer is whether short term fasting diet influences chemotherary - induced toxicities and if it is easy to be implemented.

this is a clinical trial aiming to assess the effect of fasting diet on chemotherapy - induced toxicities in breast cancer patients. the study will have an intevention group and a control group. the intervention group will follow a fasting diet for 60 hours (36h prior chemotherapy and 24h after the end of chemotherapy), while the control group will follow regular diet. at the meantime of the chemotherapy cycles, the intervention group will be recommended to follow the mediterranean diet. the patients will be randomized in the two groups. a total of 50 patients is required. biochemical data, anthropometric measures and grading of toxicity according to national cancer institute common terminology criteria for adverse events, nutritional habits, adherence to the mediterranean diet (implementation of meddietscore) will be assessed prior, during and after the intervention, in both groups. nutritional counseling will be performed by registered dietitian, and telephone interviews will be used to record adherence to fasting diet and mediterranean diet. the main questions this study is aiming to answer is whether short term fasting diet influences chemotherary - induced toxicities and if it is easy to be implemented.

Eligibility criteria:
inclusion criteria: * breast cancer patients with first diagnosis of breast cancer * no distinct metastasis * patients will receive at least 4 cycles of adjuvant or neo-adjuvant chemotherapy exclusion criteria: * bmi\<19kg/m2 * unintentional weight loss of \>3 or \>5 kg the last 3 or 6 months respectively * medical history of anorexia nervosa, boulimia or any other eating disorders * renal failure (creatinine \>2mg/dl) * diabetes mellitus (type i or insulin dependent type ii) * serious psychiatric disease * serious cardiovascular disease * mobility limitations * being participant in any other study

Keywords: fasting diet, breast cancer, chemotherapy toxicity, mediterranean diet