fludarabine based conditioning for allogeneic transplantation for advanced hematologic malignancies

Conditions: Acute Myeloid Leukemia; Acute Leukemia; Chronic Myelogenous Leukemia; Malignant Lymphoma; Hodgkin's Disease; Multiple Myeloma; Lymphocytic Leukemia; Myeloproliferative Disorder; Polycythemia Vera; Myelofibrosis; Aplastic Anemia

Summary: new conditioning regimens are still needed to maximize efficacy and limit treatment-related deaths of allogeneic transplantation for advanced hematologic malignancies. over the past several years, the investigators have evaluated several new conditioning regimens that incorporate fludarabine, a novel immunosuppressant that has limited toxicity and that has synergistic activity with alkylating agents. recent data have suggested that fludarabine may be used in combination with standard doses of oral or iv busulfan, thus reducing the toxicity previously observed with cyclophosphamide/ busulfan regimens.

treatment-related mortality and recurrence of disease account for the majority of treatment failures in allogeneic transplantation for advanced hematologic malignancies. the most commonly utilized conditioning regimens consist of cyclophosphamide and total-body irradiation or busulfan and cyclophosphamide. other agents such as etoposide or thiotepa are sometimes added to maximize the antileukemic effect. new conditioning regimens are however still needed to maximize efficacy and limit treatment-related deaths. over the past several years, the investigators have evaluated several new conditioning regimens that incorporate fludarabine, a novel immunosuppressant that has limited toxicity and that has synergistic activity with alkylating agents. recent data have suggested that fludarabine may be used in combination with standard doses of oral or iv busulfan, thus reducing the toxicity previously observed with cyclophosphamide/ busulfan regimens.

Eligibility criteria:
inclusion criteria: * patients with the following diseases: * acute myeloid or lymphocytic leukemia in first remission at standard or high-risk for recurrence. * acute leukemia in greater than or equal to second remission, or with early relapse, or partial remission. * chronic myelogenous leukemia in accelerated phase or blast-crisis. * chronic myelogenous leukemia in chronic phase * recurrent or refractory malignant lymphoma or hodgkin's disease * multiple myeloma. * chronic lymphocytic leukemia, relapsed or with poor prognostic features. * myeloproliferative disorder (polycythemia vera, myelofibrosis) with poor prognostic features. * severe aplastic anemia after failure of immunosuppressive therapy. * age 10-65 years. * zubrod performance status less than or equal to 2. * adequate cardiac and pulmonary function. patients with decreased lvef \< 40% or dlco \< 50% of predicted will be evaluated by cardiology or pulmonary prior to enrollment on this protocol. * patient or guardian able to sign informed consent. exclusion criteria: * life expectancy is severely limited by concomitant illness. * serum creatinine greater than 1.5 mg/dl or creatinine clearance less than 50 ml/min . * serum bilirubin greater than or equal to 2.0 mg/dl, sgpt greater than 3 x upper limit of normal * evidence of chronic active hepatitis or cirrhosis * hiv-positive * patient is pregnant

Keywords: acute myeloid leukemia first remission acute lymphocytic leukemia acute leukemia second remission early relapse partial remission accelerated phase blast-crisis chronic myelogenous leukemia chronic phase recurrent malignant lymphoma refractory malignant lymphoma hodgkin's disease multiple myeloma. chronic lymphocytic leukemia myeloproliferative disorder polycythemia vera myelofibrosis severe aplastic anemia