Kornimate/medical-research-clean huggingface dataset:
quality of pain management at the ziv medical center

Conditions: Focus of the Study Includes Patients in Pain

Summary: the purpose of this study is to compare attitudes and knowledge of the staff of various departments in our medical center in regards to pain treatment. with the results of our survey we will then draw up a protocol on pain management.

our belief is that the establishment of a pain protocol at the ziv medical center will improve effectiveness of pain treatment. the present study involves surveying the current knowledge and attitudes of caregivers who are responsible for evaluating pain in patients and subsequent treatment in various departments of the hospital without a pain protocol. according to the iasp (international association for the study of pain) :" pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage". according to who, assessment is necessary in every situation that involves pain, excluding pain that is life threatening. valid and reliable assessment is essential for effective pain management. the very nature of pain makes it impossible to measure objectively. there are different types of pain, and as caregivers, we need to diagnose the pain accurately in order that each patient gets the most effective treatment and continued evaluations, as needed. when caregivers decide on a treatment for pain, they are relying on the relatively objective vas (visual analogue scale.) according to recent studies most patients were dissatisfied with the pain treatment they had received. approximately eighty percent of patients who present to emergency departments worldwide come because of pain. often the patient and the caregiver have different ideas about what pain is and how to treat it. cultural differences, gender differences, even age differences may affect reactions of both the caretaker and the patient. there are many ways to treat pain, and various reasons for how people react to pain. the present study is designed to measure the knowledge and attitudes of caregivers and in regard to the pain of their patients. an assessment of patient satisfaction to pain management will be also be performed. staff members working in wards involved with pain will be asked to fill out anonymous questionnaires concerning knowledge and attitudes toward pain. patients will also be asked to fill out anonymous questionnaires in regard to their pain treatment. informed consent will be requested. responses will be collated and recorded. a future study is planned using a new pain protocol. the questionnaires will be repeated after the protocol has been in place for 12 months, at which time responses will be compared.

Eligibility criteria:
inclusion criteria: staff from the ziv medical center and patients exclusion criteria: staff members that do not deal with pain treatment
stress free now, a mind-body reduction program for nurses

Conditions: Psychological Stress; Anxiety; Depression

Summary: mindful meditation sessions have been associated with an improvement in mindfulness, perceived stress, psychological well-being, anxiety, hostility, and depression. meditation has been associated with a decrease in autonomic sympathetic activity, heart rate, oxygen consumption and energy expenditure. randomized controlled trials of online mindfulness and relaxation programs have been studied in patients with conditions such as irritable bowel syndrome, headache, depression, fibromyalgia, and insomnia. nurses may benefit from such programs given levels of job stress. this study will determine whether an online stress reduction program that incorporates meditation with and without concomitant group support reduces burnout among nurses, including emotional exhaustion and depersonalization. the proposed research study will utilize stress free now, an online stress reduction program developed by cleveland clinic wellness institute.

this is a randomized, controlled, single-center research study of an online intervention with peer group support to reduce stress in nurses. all participants will be assigned to the intervention or control groups by random number allocation. the duration of the intervention is 6 weeks; follow-up is at 6 and 24 weeks; the duration of the study is 6 months (24 weeks). total individual participant time commitment will depend on particular intervention or control group assignment. both intervention and control groups will be requested to complete a set of questionnaires at weeks 0, 6, and 24. the questionnaires will take an estimated 45 minutes to complete.

Eligibility criteria:
inclusion criteria: * be at least 18 years of age * work as a full-time or part-time nurse at cleveland clinic * have regular internet and email access and be willing and able to attend group support sessions * work at least one weekday during the week in order to attend orientation and/or group support sessions exclusion criteria: * participating in another stress reduction research study * pregnant, lactating, or planning to be pregnant in the next 6 months * hospitalized for depression in past 12 months * vacation time away from work for more than 1 week during the first 2 months of the study * current diagnosis of schizophrenia, other psychotic or bipolar disorder * other medial, psychiatric, or behavioral limitations that may interfere with study participation or the ability to follow the intervention protocol * unwilling or uninterested in participating in group sessions

Keywords: perceived stress burnout mindfulness intent to leave nursing
a study to evaluate the safety, pharmacokinetics and efficacy of ak120 in subjects with atopic dermatitis

Conditions: Atopic Dermatitis

Summary: this is a randomized, double-blind, placebo-controlled, multicenter phase ib/ii clinical study to evaluate the safety, pharmacokinetics and efficacy of ak120 in the treatment of subjects with moderate to severe atopic dermatitis.

this is a randomized, double-blind, placebo-controlled, multicenter phase ib/ii clinical study to evaluate the safety, pharmacokinetics and efficacy of ak120 in subjects with moderate to severe atopic dermatitis.

Eligibility criteria:
inclusion criteria: 1. male or female with age 18 - 75 years (inclusive). 2. atopic dermatitis (ad) diagnosed at least half an year before screening. 3. subject with easi score ≥16, iga ≥ 3, bsa ≥ 10% at screening and baseline. 4. subjects with a history of an inadequate response or medically inappropriate use of topical drug treatment within 6 months. exclusion criteria: 1. suffering from other inflammatory diseases that may affect efficacy outcomes (such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, scleroderma, inflammatory myopathy, mixed connective tissue disease, overlap syndrome, etc.). 2. history of exposure to active tb, and/or history or current evidence of tb infection. 3. positive serology results at screening for hepatitis b, hepatitis c or hiv. 4. any history of vernal keratoconjunctivitis (vkc) or atopic keratoconjunctivitis (akc) within 6 months before the baseline visit. 5. history of clinical parasite infection, recent or planned travel to an area with endemic parasite infection within 6 months before the screening visit 6. any medical or psychiatric condition, laboratory, or ecg parameter which, in the opinion of the investigator or the sponsor's medical monitor, would place the subject at risk, interfere with participation in the study, or interfere with the interpretation of study results.
effects of levosimendan on cellular metabolic alterations in patients with septic shock

Conditions: Septic Shock

Summary: to investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following levosimendan administration in patients with septic shock.

the study was designed as a prospective, double-blind, controlled, clinical trial and performed in a multidisciplinary intensive care unit. after achieving normovolemia and a mean arterial pressure of at least 65 mmhg, 20 septic shock patients were randomized to receive either levosimendan 0.2 μg/kg/min, or dobutamine 5 μg/kg/min. interstitial tissue concentrations of lactate, pyruvate, glucose and glycerol were obtained by using muscle microdialysis. all measurements, including data from right heart catheterization were obtained at baseline and every 6 hours for the following 72 hours after randomization.

Eligibility criteria:
inclusion criteria: * patients who fulfilled the criteria of septic shock that required norepinephrine (ne) to maintain a mean arterial pressure (map) of at least 65 mm hg despite appropriate volume resuscitation (pulmonary arterial occlusion pressure \[paop\] = 12 to 18 mm hg and central venous pressure \[cvp\] = 8 to 12 mm hg) exclusion criteria: * pregnancy, uncontrolled hemorrhage, terminal heart failure, significant valvular heart disease, documented or suspected acute coronary syndrome, and a limitation on the use of inotropes: left ventricle outflow obstruction, systolic anterior motion of the mitral valve.
pramipexole for restless leg syndrome in peritoneal dialysis patients

Conditions: Restless Legs Syndrome

Summary: a randomized, double-blind controlled study from a single center to evaluate the effect and safety of pramipexole on peritoneal dialysis patients with restless legs syndrome

peritoneal dialysis patients diagnosed with restless legs syndrome will be divided into experiment group and control group, and will be prescribed with pramipexole and placebo respectively.after 12 weeks, we will compare irlssg（international rls study group rating scale）、mos（medical outcomes study ）sleeping scale、self-rating anxiety scale and self-rating depression scale before and after the prescription.

Eligibility criteria:
inclusion criteria: 1. pd patients (aged ≥18 years) are dialyzed with lactate-buffered glucose dialysate, using a twinbag connection system (baxter healthcare, guangzhou, china). 2. for entry , all patients are required to meet all diagnositic criteria of the international rls study group (irlssg), to have a baseline total score \>15 on the study group's international rls rating scale (irls), and to have experienced rls symptoms at least 2-3 days per week throughout the perior 3 months. 3. each patient should write informed consent. 4. all patients are required to be interviewed to the frequency required by the research process. exclusion criteria: 1. patients with severe gastrointestinal illness can not tolerate oral drugs. 2. patients who work on a shift schedule are not allowed to participate. 3. women with childbearing potential are excluded for pregnancy, inadequate contraception, or current breastfeeding of a child. 4. patients are also excluded for current use (within 14 days before baseline) of medications that might affect rls symptoms, e.g., levodopa, dopamine agonists or antagonists, hypnotics, lithium formulations, or antidepressants. 5. patients with serum ferritin ≤200 ng/ml, or hb \<110g/l, or kt/v \<1.7 are excluded. 6. patients with severe and unstable inflammation disease (active systemic infection, acute cardiovascular disease, active liver disease, active connective tissue disorder, ,and cancer within 1 year of radiotherapy and chemotherapy, )

Keywords: pramipexole, restless leg syndrome peritoneal dialysis
pre-op tha modelling

Conditions: Total Hip Arthroplasty; Computer-Assisted Surgery

Summary: replacing diseased hip joints with prosthetic implants in a procedure called total hip arthroplasty (tha) is associated with high rates of patient satisfaction, pain relief, and functional improvement when the implant is appropriately placed. incorrect implant size or placement may lead to a breadth of negative outcomes, which could result in the need for implant revision. it is difficult to assess the precise orientation of patient hips on the operating table, with one study revealing that only 26% of acetabular cups placed without technological assistance are correctly positioned. using computer navigation as a guide to achieve optimal implant alignment may improve successful placement rates. the additional incorporation of real-time modeling software may further help realize higher rates of successful implant placement. this study, therefore, aims to investigate a computer navigation system coupled with real-time modeling software to establish the benefit of such technology in the operating room, and further improve positive patient outcomes following tha. we hypothesize that including technological assistance in thas will yield better patient outcomes compared to surgeries performed freehand.


Eligibility criteria:
inclusion criteria: * osteoarthritis of the hip requiring primary tha * 40 years of age or older * bmi \<40 kg/m2 * able to provide informed consent, able and willing to do study assessments and follow instructions exclusion criteria: * prior surgery on the indicated hip with insertion of hardware * prior surgery on the lower spine with insertion of hardware * hip and/or spinal fixed deformities or inflammatory/ossification processes of the spine (e.g. dish, ankylosing spondylolisthesis) * limitations to range of motion of the contralateral hip

Keywords: osteoarthritis joint disease musculoskeletal disease
a trial on treatments of hirschsprung allied disease

Conditions: Complications of Treatment; Complication of Surgical Procedure; Megacolon, Not Hirschsprung

Summary: the present study was designed to compare the efficacy of conservative treatment to operative treatment for improvement of constipation symptoms in children with hirschsprung allied disease

the present study was designed to compare the efficacy of conservative treatment,such as anal dilatation, colonic lavage and so on, to operative treatment for improvement of constipation symptoms in children with hirschsprung allied disease

Eligibility criteria:
inclusion criteria: * hard or firm stools for twice or less per week * a predicting score of less than 5 refer to literature: wu, x.j., et al., a new diagnostic scoring system to differentiate hirschsprung's disease from hirschsprung's disease-allied disorders in patients with suspected intestinal dysganglionosis. int j colorectal dis, 2013. 28(5): p. 689-96 exclusion criteria: * functional constipation * a predicting score of more than 5 refer to literature: wu, x.j., et al., a new diagnostic scoring system to differentiate hirschsprung's disease from hirschsprung's disease-allied disorders in patients with suspected intestinal dysganglionosis. int j colorectal dis, 2013. 28(5): p. 689-96
accuracy of infrared thermography for detecting febrile critically ill patients

Conditions: Temperature Monitoring

Summary: accurate determination of critically ill patient of being febrile or not is an essential part of management critically ill patients as it prompt investigating the underlying cause and initiating therapeutic action. pulmonary artery catheter thermistor is considered the gold standard for temperature measurement . central non-vascular thermometer such as esophageal, bladder and rectal thermometer showed excellent correlation and agreement with pulmonary artery catheter thermistor and has been accepted as alternative methods for core body temperature assessment. however, those methods are invasive and cannot be tolerated in conscious patients. peripheral thermometer such as oral, axillary and tympanic membrane thermometer are either impractical in unconscious patient and/or carry the risk of trauma and infection. infrared thermography (irt) is a non-contact and non-invasive imaging approach that enable real-time estimation of body temperature by detecting infrared emission. irt had been used for screening for mass detection of febrile patients at airport at times of infectious disease outbreak. in adult population, irt showed good accuracy in detecting febrile patients in emergency department; however, those studies used 37.7⁰ c as the fever threshold and the reference standard was either oral 6 or tympanic membrane thermometer. no studies to the best of our knowledge had evaluated the irt accuracy in detecting fever in critically ill patients using esophageal thermometer as a reference method.

the enrolled patient will be sedated according to the icu protocol. a calibrated esophageal thermometer will be inserted by the attending intensivist through the nostril or oral cavity into the lower third of the esophagus to approximately 10-20 cm. irt will be performed using flir c2 compact thermal camera. the focal length of the thermal camera will be adjusted at 0.5 meter from the patient head. scanning will conducted over a period of 10-seconds. the researcher will record the highest reading obtained from medial canthus. no cold fomentations will be applied to the head nor the axilla of the patient for 30 minutes at least before measuring irt. flir c2 thermal camera will be calibrated before use to eliminate the effect of the ambient room temperature. the researcher of will obtain the irt temperature will be blinded to the esophageal probe reading.

Eligibility criteria:
inclusion criteria: * critically ill intubated adult patients (\>18 years) exclusion criteria: * patients with condition that preclude the application of esophageal thermometer such as esophageal varices, diverticulum, stenosis and malignancy * patients with eye pathology as inflammation or malignancy which would interfere with the interpretation of the irt reading, * pregnant women.
csf pharmacokinetics of ondansetron

Conditions: Pain

Summary: serotonergic 5-ht3 receptors in the central nervous system are involved in pain processing after nerve injury. we are interested in learning if 5-ht3 receptor antagonist ondansetron might be an appropriate drug for treating pain after nerve injury (neuropathic pain), by investigating its bio-distribution in the cerebro-spinal fluid, and the genetic variability that may affect that distribution. study procedures will include iv ondansetron administration, serial blood draws, cerebrospinal fluid (csf) sampling, pregnancy testing, and possible ecg.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 70 years old; 2. patients planned to undergo hip or knee arthroplasty with spinal anesthesia; 3. ability to provide informed consent exclusion criteria: 1. not giving consent to participate in the study; 2. patients with history of or current hepatic or renal insufficiency; 3. patients with bmi ≥ 33; 4. patients with heart failure or active arrhythmias; 5. patients with severe systemic disease that is a constant threat to life; 6. contraindication or allergy to ondansetron; 7. pregnancy or lactation. 8. prisoners
evaluation of the effectiveness of a community health management program for dry eye disease in middle-aged and elderly individuals

Conditions: Dry Eye Disease

Summary: this study evaluates the effectiveness of a community health management program for middle-aged and elderly patients with dry eye disease (ded). by comparing the community-based health management plan with conventional treatment, the study aims to determine the impact on eye health and quality of life.


Eligibility criteria:
inclusion criteria: 1. patients meeting the diagnostic criteria for dry eye disease. 2. middle-aged and elderly individuals aged 45 years and above. 3. normal cognitive and expressive abilities. 4. informed consent and ability to complete the survey. 5. voluntary participation in the study. exclusion criteria: 1. patients with other ocular surface diseases, including stye, trachoma, allergic conjunctivitis, etc. 2. patients with severe cataracts, glaucoma, uveitis, retinal detachment, optic nerve diseases, high myopia, or other conditions. 3. patients who have undergone eye surgery or have a history of eye trauma in the past three months. 4. patients who did not sign the informed consent form.
differential diagnosis and cause-specific treatment during ohca

Conditions: Out-Of-Hospital Cardiac Arrest

Summary: differential diagnosis: ultrasound, blood gas analyse combined with examination of the patient and environment is used during out of hospital cardiac arrest (ohca) to screen possible underlying cause of cardiac arrest. helicopter emergency medical service (hems) in helsinki has unraveled a protocol for performing differential diagnosis during ohca. our study aim is to test the feasibility of this protocol. our study is a prospective medical record based study. the anesthesiologist operating in the hems unit fills a form after encounter of ohca. questioners focus on how long did execution of the protocol take, and the cause if the protocol was not completed.


Eligibility criteria:
inclusion criteria: * non-traumatic out-of-hospital cardiac arrest encountered by the helicopter emergency medical services team exclusion criteria: * return of spontaneous circulation before hems crew arrival * termination of resuscitation attempt before hems crew arrival

Keywords: out of hospital cardiac arrest differential diagnosis prospective ultrasound blood gas analyse
short and long-term results of arterial stiffness and central aortic pressure after kidney transplantation

Conditions: Arterial Calcification; Aortic Stiffness; High Blood Pressure (& [Essential Hypertension])

Summary: central blood pressure and pulse wave velocity were measured using a complior analyse device in short and long-term after kidney transplantation.


Eligibility criteria:
inclusion criteria: * give voluntary consent to participate in the study * functioning graft longer than 3 months to 10 years * no clinical cardiovascular disease during the 6 months preceding entry * stable graft function- glomerular filtration rate \> 30 ml/min/1.73 m2, creatinine concentration \<2.5 mg/dl * medical staff (medical doctors, nurses) exclusion criteria: * not meet the above criteria * episode of illness (for example: infection) * pregnancy
human amniotic epithelial cells for asherman's syndrome

Conditions: Asherman's Syndrome

Summary: this project aims to investigate the safety and effectiveness of human amniotic epithelial cells in the treatment of the severe refractory asherman's syndrome.

asherman's syndrome is a gynecological disorder caused by the destruction of the endometrium due to repeated or aggressive curettages and/or endometritis. as a result, there is a loss of functional endometrium in multiple areas and the uterine cavity is obliterated by intrauterine adhesions, which results in amenorrhea, hypomenorrhea, infertility and recurrent pregnancy loss. transcervical resection of adhesion (tcra) is the main treatment for asherman's syndrome, so far the effect is usually poor in moderate to severe refractory cases. human amniotic epithelial cells (haecs) are derived from human amniotic epithelium. haecs retain the characteristics approximating to embryonic stem cells. animal experiments have shown that the endometrial thickness and fertility of mice were significantly improved after intrauterine therapy with amniotic epithelial cells. to further explore the role of haecs in asherman's syndrome patients, this project plans to evaluate the safety of haecs provided by chongqing icell biotechnology co.,ltd., which is a subsidiary of shanghai icell biotechnology co.,ltd., and find an effective treatment protocol.

Eligibility criteria:
inclusion criteria: * 1. hysteroscopy examination confirms intrauterine adhesions, ii -iii according to the american fertility society (afs) classification of uterine adhesions; * 2. regular menstrual cycles and menstruation is normal before abortion or curettage; * 3. having a clear desire to fertility; * 4. normal blood coagulation, liver, heart, and kidney function, absence of hiv, hepatitis b or c, syphilis and psychiatric pathology; * 5. serum β-hcg is negative; * 6. be willing to complete the study and sign the consent form. exclusion criteria: * 1. having a history of malignant tumor; * 2. having other uterine diseases, such as, uterine fibroids, adenomyosis and uterine malformations; * 3. hysteroscopic adhesiolysis more than 3 times in the past; * 4. absence of peripheral vein access.