Kornimate/medical-research-clean huggingface dataset:
virtual reality and robotics in inflammatory myopathy rehabilitation

Conditions: Inflammatory Myopathy

Summary: the goal of this clinical trial is to learn if a virtual reality based robot assisted dual task intervention leads to better rehabilitation effects than standard physical therapy in patients with inflammatory myopathy. the main question it aims to answer is whether a non-immersive virtual reality based rehabilitation improves muscular strength and relieves psychological distress to a greater extent than standard physical therapy conducted by physiotherapists. * participants will be divided into intervention and control group. * the control group will participate in a standard rehabilitation program consisting of exercise sessions with physiotherapists. * the intervention group will train on the robotic devices (zebris treadmill, alfa stabilometric platform, diego robotic set). * both group will train from 4 to 6 weeks, 5 times a week. * 6 weeks after completing the rehabilitation program, patients will return for a follow-up assessement.


Eligibility criteria:
inclusion criteria: * age ≥ 18 y.o, * meeting the bohan/peter criteria for myositis or the enmc criteria for immune-mediated necrotising myopathy and for inclusion body myositis, * reduced muscular strength defined by ≤ 64/80 result in mmt-8 and/or ≤ 7/10 result in mmt in ≥ 1 proximal muscle group exclusion criteria: * severe cardiopulmonary diseases, * concurrent malignancies, * severe psychiatric disorders * injuries and comorbidities preventing exercise participation

Keywords: virtual reality robot assisted rehabilitation dual-task intervention randomised controlled trial
medium-term effects of molecular hydrogen on metabolic fitness in obesity

Conditions: Obesity

Summary: molecular hydrogen (h2) effectively tackles obesity-related disorders in animal models yet no studies so far investigated the effectiveness of h2 for improving biomarkers of obesity in humans. in this double blind, placebo-controlled, crossover pilot trial, the investigators will evaluate the effects of h2 intervention on body composition, hormonal status, and mitochondrial function in middle age overweight women, with hydrogen administered orally for 4 weeks.


Eligibility criteria:
inclusion criteria: * age \> 55 years * body mass index \> 25 kg/m2 exclusion criteria: * no history of h2 supplementation within the 4 weeks before study commenced * no major chronic diseases, as evaluated by pre-participation health screening and clinical chemistry

Keywords: overweight molecular hydrogen insulin
the cardiopulmonary effects and diaphragm function of complete inspiratory muscle training in patients with upper abdominal surgery

Conditions: Inspiratory Muscle Training; Postoperative Pulmonary Complications; Respiratory Muscle Function; Abdominal Surgery

Summary: upper abdominal surgical treatment may have reduced respiratory muscle function and mucociliary clearance, which might be a consequence of postoperative pulmonary complications (ppcs). the threshold inspiratory muscle training (imt) may serve as an effective modality to improve respiratory muscle strength and endurance in patients. however, whether this training could help patients with upper abdominal surgery remain to be determined.


Eligibility criteria:
inclusion criteria: 1. ≧20 years old with upper abdominal surgery, 2. american society of anesthesiologists; asa) i-iv 3. body mass index; bmi≥ 18 4. able to follow exercise protocol. t exclusion criteria: 1. history of prior abdominal surgery 2. high risk of exercise contraindications (e.g. severe cardiac or cardiovascular disease), 3) american society of anesthesiologists; asa) v-iv 4) unable to follow exercise protocol 5) severe organ failure

Keywords: inspiratory muscle training postoperative pulmonary complications respiratory muscle function abdominal surgery
opioid sparing effect of thoracic epidural analgesia for open upper abdominal surgery

Conditions: Hepatoma; Pancreas Cancer

Summary: this prospective randomized controlled study is aimed to determine the advantages of thoracic epidural analgesia for open upper abdominal surgery in combination with multimodal analgesia compared with no thoracic epidural analgesia on postoperative pain control. the primary outcome is total opioid consumption in postoperative 72 hours. secondary outcomes are the success of continuous epidural analgesia or complications of this technique, pain intensity, morbidity and mortality compare to no continuous epidural analgesia.

continuous epidural analgesia (cea) for open upper abdominal surgery has been showed the analgesic analgesia for open abdominal surgery. however the technical difficulty, complications especially hypotension, pruritus of cea impede the popularity of technique compared to intravenous patient-controlled analgesia (iv pca) in multimodal analgesia. this study is aimed to study of the role of cea and multimodal analgesia in open abdominal surgery compare to iv pca.

Eligibility criteria:
inclusion criteria: * age 18-80 years * open upper abdominal surgery * american society of anesthesiologists (asa) grade i-iii exclusion criteria: * contraindications to cea * inability communication * patient's refusal * emergency surgery * bmi \> 35

Keywords: open upper abdominal surgery continuous epidural analgesia
evaluation of an mhealth behavioural intervention for the self-management for type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to evaluate a patient-centered diabetes self-management mobile application (app), which was developed with feedback from both patients and healthcare providers. during the 12 month randomized control trial, participants in the intervention group will be provided with a mobile phone and commercial home medical devices, such as a weight scale, glucometer and activity monitor. the measurements taken from the medical devices will wirelessly transfer to the mobile phone, where the app will assess the data and provide patients with actionable self-management knowledge. the proposed intervention may be helpful in increasing adherence to recommended self-care practices, improving self-efficacy, and enhancing the overall patient experience.


Eligibility criteria:
inclusion criteria: * english-speaking individuals * diagnosed with non-insulin requiring type 2 diabetes * outpatients * baseline a1c of 7.5% or higher exclusion criteria: * patients who are deemed unable to use a mobile phone (e.g. due to vision problems), and/or to comply with home monitoring (e.g. suffering from anxiety or depression) * diabetes duration \<1 year

Keywords: diabetes mellitus randomized controlled trial primary care physical activity lifestyle blood glucose mobile health hb a1c self-management
appendectomy by low impact laparoscopy vs routine laparoscopy : a randomized prospective monocentric trial

Conditions: Appendicitis; Appendectomy

Summary: introduction: surgery performed under low insufflation pressure combined with micro-laparoscopy (incisions 4x smaller than incisions in conventional laparoscopy) is called "low impact laparoscopy" or lil. it significantly reduces postoperative pain and reduces the average length of stay. this technique, currently underdeveloped has never been evaluated in the literature for appendectomy. main objective of the study: to obtain a reduction in postoperative pain when using the low-impact laparoscopy technique for appendectomies. secondary objectives: to study the feasibility of lil in appendectomies, to obtain a reduction in the average length of stay, a reduction in the consumption of analgesics, a reduction in costs, and a more rapid resumption of activities. material and methods : this is a prospective, single-center, double-blind study. the inclusion criterion is the presence of acute uncomplicated appendicitis. the number of subjects to be included in each group is evaluated at 25. the subjects are divided into two groups preoperatively: * conventional group: insufflation pressure at 12mmhg and conventional instrumentation * lil group: insufflation pressure at 7mmhg and micro-laparoscopy instrumentation. identical dressings are put in place at the end of the procedure in order to hide from the patient the protocol in which he was included. pain assessment is recorded daily during the first postoperative week. the consumption of analgesics is also recorded. then on the 7th day, 15th day and 30th postoperative day. during hospitalization, readings are taken by the nurse. at home, the data is entered by the patient via the link4life smartphone application. conclusion: lil applied to appendectomy has never been evaluated in the literature. it would allow a reduction in postoperative pain, the average length of stay for patients as well as improved rehabilitation.


Eligibility criteria:
inclusion criteria: - patients with acute appendicitis uncomplicated by computed tomography with injection of contrast product exclusion criteria: * coagulopathy or thrombopathy * arguments for a complicated appendicitis: fever\> 38.5 ° c, hyperleucytosis\> 15,000, crp\> 100, presence of an intraperitoneal abscess, a plastron, a fluid effusion of medium or great abundance or '' a pneumoperitoneum on the ct scan * history of abdominal surgery by laparotomy * obese patients (bmi\> 30kg / m2) * minor patients * patients without health insurance * pregnant patient * patient incarcerated or in detention * patient under guardianship or curatorship * rapid sequence induction with the use of ketamine
postpartum weight loss for women at elevated cardiovascular risk

Conditions: Weight Loss; Postpartum Weight Retention; Hypertension in Pregnancy; Diabetes Mellitus in Pregnancy; Preeclampsia; Recruitment

Summary: the aim of this study is to test the feasibility and effectiveness of a 16-week online behavioral weight loss program compared to usual care to promote weight loss in the postpartum period among women with cardiovascular risk factors. the investigators will also be testing different behavioral strategies to recruit postpartum women to the study, including 2 email recruitment strategies and 2 mailer recruitment strategies, informed by behavioral design.


Eligibility criteria:
inclusion criteria: 1. age ≥18 years; 2. delivered a baby at hup or pah within 3-12 months prior to study start; 3. bmi ≥ 27 kg/m2 4. diagnosis of one of the following medical conditions: chronic hypertension, gestational hypertension, preeclampsia, eclampsia, gestational diabetes, or diabetes mellitus (type 1 or 2) based on diagnosis codes in the emr 5. has online access through smartphone or computer and has email address 6. ability to read and provide informed consent to participate in the study exclusion criteria: 1. delivered prior to 32 weeks gestation in the emr 2. documentation of fetal demise or neonatal demise in the emr 3. currently pregnant or planning to get pregnant within the next 5 months 4. does not speak english 5. answers yes to any of the following questions: * are you currently participating in any other weight loss or physical activity studies? * do you have any medical conditions or other reasons why you could not participate in a 16-week weight loss or physical activity program? 6. participants will be excluded after completing the run-in period if they do not complete the daily food log or their baseline bmi is \< 27 kg/m2

Keywords: weight loss postpartum period hypertension in pregnancy cardiovascular risk reduction diabetes prevention program
the effect of iv amantadine on freezing of gait (fog) resistant to dopaminergic therapy

Conditions: Parkinson's Disease; Freezing of Gait

Summary: tp determine the effect of iv amantadine on dopaminergic-drug-resistant freezing of gait(fog)in patients with parkinson's disease

1. freezing of gait (fog) is one of the most disabling symptoms of parkinson's disease. we experienced that severe fog was markedly improved by iv amantadine in the patients who had parkinson's disease. but iv drug may have placebo effect. therefore, we designed double blind, placebo controlled study to know whether iv amantadine is effective in the patient with dopaminergic-drug-resistant freezing of gait(fog). 2. cross over study design * compare the change of fogq(freezing of gait questionaire) score from the baseline to iv amantadine and placebo drug * randomized assigned order of amantadine and placebo drug. * investigator of fog: blinded to the order of drugs * each patient has iv drug for 2 days for each drug

Eligibility criteria:
inclusion criteria * age: 30-80 years * idiopathic parkinson's disease * the patient must be taking optimised levodopa/ddi therapy (based on investigator's judgement) during opd observation period, though the patient have fog-q score ≥ 10 points even though on-state. exclusion criteria: * "off" freezing:the patient has improved fog in "on" state * clinically significant or unstable medical or surgical condition * the patient has parkinson plus like msa, psp, and ppfg, and secondary parkinsonism like nph, vascular parkinsonism, postencephalitic parkinsonism, co poisoning. * history of seizure.

Keywords: freezing
genetic analysis of patients with pseudoxanthoma elasticum

Conditions: Pseudoxanthoma Elasticum; PXE

Summary: this study will characterize the gene mutations responsible for pseudoxanthoma elasticum (pxe) and correlate them with disease manifestations in males and females. pxe is an inherited disorder that affects the connective tissue in some parts of the body. calcium and other minerals are deposited in the connective tissue, causing changes in the skin, eyes, cardiovascular system and gastrointestinal system. some effects of pxe can cause serious medical problems, while others have less impact. symptoms often appear earlier and are more severe in females than in males, but there is no way to predict how the disorder will progress in any given individual. candidates for this study are recruited through pxe international, an organization that provides patient support and supports research on the disease. the organization collects biological samples and medical information on patients and family members to help further research on the disease. families that have samples from the patient, both parents, and at least one sibling may be eligible for this study. grandparents and extended family members may be included in certain instances. participants provide a blood sample, a sample of cells scraped from the inside of the cheek (buccal cells) and a medical history. the samples are analyzed for gene variants and the findings are correlated with disease signs and symptoms. ...

background: * pseudoxanthoma elasticum (pxe) is an autosomal recessive genetic disorder characterized by mutations in the atp-binding cassette transporter, abcc6. * pxe while it is known that patients have two mutated alleles of the abcc6 gene, significant questions remain about the segregation of the disease, the presentation in males versus females and the correlation of mutation to clinical phenotype. objectives: - the objective is to examine the role of variants in the abcc6 gene in pxe. eligibility: * samples from study participants were obtained through the pxe international biobank. * families were selected that have samples from both parents and at least one sibling in addition to the proband. design: - participants dna was sequenced to identify variants and genotyped for linked markers to follow the segregation of mutant alleles and compare the results with the clinical outcomes.

Eligibility criteria:
* inclusion/exclusion criteria: a representative set of collected families will be studied. no subjects within these families will be excluded. families will be selected that have samples from both parents and at least one sibling in addition to the proband. the siblings will include both affected and unaffected. if grandparents are available they will also be typed to help in phase determination. extended relatives will only be selected in multiple generation families.

Keywords: abc transporter abcc6 slkin laxity genetic association angiod streaks pseudoxanthoma elasticum pxe
prospective observational study for the evaluation of veofix varisation staples

Conditions: Hallux Valgus

Summary: this clinical investigation was led as a post-market clinical follow-up study (post-market device development stage). therefore, its objectives were as follows: * to assess functional clinical score's evolution, * to evaluate patient's satisfaction * to confirm safety of varisation staples the target population for this study was any adult patient implanted with veofix varisation staples in their intended uses between 15/02/2021 and 15/05/2021. patients were implanted and followed as per standard of care led in the investigational site. the following regulation and guidelines were followed for this investigation: * standard iso 14155:2020 "good clinical practice"undirectly applicable; * regulation (ue) 2016/679 (rgpd) ; * regulation (ue) 2017/745 (mdr) ; * meddev 2.12.1; * local regulation (loi " jardé ", loi " informatique et libertés "). as per its design, the investigation is considered as involving human beings, and therefore require submission to an ethic committee or declaration to a competent authority (ansm) and cpp. this study was registered on cpp (cpp ile de france vii).


Eligibility criteria:
inclusion criteria: * man or woman * major patient on the date of surgery * patient with foot pathology requiring akin osteotomy * patient not opposed to the collection of data exclusion criteria: * patient unable to understand and follow the postoperative instructions * patient with a contraindication to the use of the implant * non-implanted patient with a varisation staple
acupuncture for hot flashes in patients with hormone receptor-positive breast cancer.

Conditions: Hot Flashes; Breast Cancer; Acupuncture

Summary: this study intends to further evaluate the efficacy of acupuncture by comparing the intervention effects of different acupuncture treatment regimens on hot flashes in breast cancer ; and to explore the central effect regulation mechanism of acupuncture intervention on hot flashes based on functional magnetic resonance imaging technology.

this topic combines the theory of "unblocking the governor and warming the yang" with the important findings of modern research, that is, the important mechanism of the spine in the pathogenesis of breast cancer, and innovatively proposes the technique of unblocking the governor and treating the spine. prospective clinical intervention research in rehabilitation, objectively evaluate the clinical efficacy, advantages and disadvantages of this technology, so as to effectively break through the current application dilemma of acupuncture and bone-setting manipulation in tumor diseases.

Eligibility criteria:
inclusion criteria: * aged 18-75 years old; * adjuvant hormone therapy (eg, tamoxifen and/or aromatase inhibitors) with or without ovarian function suppression has been administered for at least 4 weeks and is currently on treatment; * vasomotor syndrome for at least 6 weeks; * premenopausal or postmenopausal patients; * patients with persistent hot flashes for at least 4 weeks and with a frequency of more than 14 hot flashes per week (2 times per day) in the week before inclusion in the study, the weekly average hot flash composite score is 3-4; * patients after surgery and after chemotherapy (if any); * eastern cooperative oncology group score of 0-1 points. * sign the informed consent and voluntarily participate in this clinical observation. exclusion criteria: * tumor metastases, undergoing chemoradiotherapy or planning surgery; * pharmacological intervention for hot flashes with hot flash treatment drugs such as selective serotonin reuptake inhibitors (ssris) and/or anticonvulsants for at least 4 weeks prior to study initiation; * unstable heart disease or myocardial infarction within 6 months prior to study start; * started or changed adjuvant hormone therapy within the past week, or who planned to start or change adjuvant hormone therapy in the past 14 weeks; * seizures of unknown likelihood or history of seizures; * have used acupuncture for hot flashes within 6 months prior to the start of the study; * pregnant or breastfeeding patients; * apparent uncontrolled infection; * mental illness or family history; neurological disorder or family history.

Keywords: breast cancer acupuncture hot flashes functional mri
perturbed-balance training during treadmill walking for stroke subjects

Conditions: Stroke

Summary: a control and a post-stroke subject with right-side chronic hemiparesis were studied. the post-stroke subject underwent 30 sessions of balance-perturbed training while walking on an instrumented treadmill where the balance assessment robot (bar™) randomly delivered pushes to pelvis in various directions at various speeds and at various perturbation amplitudes. the investigators assessed kinematics, kinetics, electromiography and spatio-temporal responses to outward-directed perturbations commencing either at foot contact of the left or the right leg.

for a detailed description of the study, see the arms and interventions section.

Eligibility criteria:
inclusion criteria: * case: community-dwelling, high-functioning stroke survivor * control: healthy volunteer, height- and weight-matched to the case exclusion criteria: * any disease or injury affecting cognition * any disease or injury affecting balance or gait

Keywords: perturbed walking stepping response
a study of ly3502970 in participants with type 2 diabetes mellitus

Conditions: Type 2 Diabetes

Summary: the main purpose of this study is to evaluate the efficacy and safety of ly3502970 in participants with type 2 diabetes (t2d) who failed to achieve adequate glycemic control on diet and exercise alone or on a stable dose of metformin. this study will last about 30 weeks.


Eligibility criteria:
inclusion criteria: * have been diagnosed with type 2 diabetes on diet and exercise and/or a stable dose of metformin * have a stable body weight for the 3 months prior to randomization * have a body mass index (bmi) ≥23 kilogram/square meter (kg/m²) * males must agree to use highly effective methods of contraception * women not of childbearing potential (wnocbp) may participate in this trial * note: hormone replacement therapy in post-menopausal women is allowed but women must be on stable therapy for 3 months prior to day 1. exclusion criteria: * have type 1 diabetes mellitus (t1dm) or history of ketoacidosis or hyperosmolar coma * have a history of diabetic retinopathy, diabetic maculopathy, or severe non-proliferative diabetic retinopathy that requires immediate treatment intervention * have had more than 1 episode of severe hypoglycemia and aware of hypoglycemic symptoms * have acute or chronic pancreatitis * have obesity induced other endocrine disorders (cushing's syndrome or prader - willi syndrome) * have gastric emptying abnormality or chronically take medications impacting gi motility * have poorly controlled hypertension * have the following heart conditions within the last 6 months: myocardial infarction (mi), unstable angina, coronary artery bypass graft, percutaneous coronary intervention (diagnostic angiograms are permitted), transient ischemic attack (tia), cerebrovascular accident (stroke)or decompensated congestive heart failure, or iv heart failure * have any symptoms of other liver diseases besides nonalcoholic fatty liver disease (nafld) * have hiv, or hepatitis b or hepatitis c