determination of the postprandial responses to two cereal foods differing by their sds content consumed alone.

Conditions: Metabolic Disorder; Carbohydrate, Absorption, Intestine

Summary: this study aimed at determining the 4-hours postprandial blood glucose and insulin responses to the ingestion of cereal product differing by their sds content.

this study aimed at determining the 4-hours postprandial blood glucose and insulin responses to the ingestion of cereal product differing by their sds content. it is a laboratory-based research study with an open cross-over design, including 20 healthy non-smoking voluntary subjects, aged from 18 to 45 years. 2 test sessions per subject are included in the study. foods are consumed in a random order according to a randomisation list.

Eligibility criteria:
inclusion criteria: * aged between 18-45 years. * non-smoker. * bmi values between 19-30 kg/m2 (bounds included). around half of the subjects will be normal weight and the other half overweight. * ethnicity. subjects should have the closest characteristics compared to the american population. not less than 75% but not more than 90% of the subjects should be caucasian. not more than 10% of the subjects will be of asian or asian indian descent. the remaining subjects will be from other ethnic groups except from australian aborigines. * healthy subjects with: * normal glucose tolerance (fasting blood glucose \< 6.0 mmol/l during the first test session and results of oral glucose tolerance test conducted within the last 30 days within recommendations (fasting blood glucose \< 6.0 mmol/l, 120 minute glucose \< 8.9 mmol/l)) * normal laboratory values for various measures of metabolic health (full blood count, gamma-gt, ast, alt, glucose, tags, total cholesterol, hdl-cholesterol, ldl-cholesterol); * normal systolic blood pressure (100-150 mmhg); * normal diastolic blood pressure (60-90 mmhg); * normal resting heart rate (50-90 beats per minutes after 3 minutes rest). * stable dietary habits; normal eating patterns; no history of eating disorders or strict dieting. * moderate level of physical activity (from basic daily activity to a high level of physical activity (regular physical activity at least 3 times per week) * able to fast for at least 10 hours the night before each test session * able to refrain from eating legumes and drinking alcohol the day before each test session. * subject covered by social security or covered by a similar system * subject not taking any treatment for anorexia, weight loss, or any form of treatment likely tointerfere with metabolism or dietary habits * subject having given written consent to take part in the study. exclusion criteria: * following a restrictive diet. * family history of diabetes mellitus or obesity * suffering from any clinical, physical or mental illness. * suffering from any food allergies or hypersensitivities (wheat, milk, egg, nuts, etc). * taking any regular prescription medication at the time of inclusion (except regular oral contraception medication) * subject from the australian aboriginal ethnicity. * female who is pregnant (positive test results), lactating, planning pregnancy or not using acceptable contraceptive. * females who consistently suffer from premenstrual tension and marked changes in appetite during their menstrual cycle. * subject having taken part in another clinical trial within the last week. * subject currently taking part in another clinical trial or being in the exclusion period of another clinical trial. * subject undergoing general anaesthesia in the month prior to inclusion. * subject in a situation which in the investigator's opinion could interfere with optimal participation in the present study or could constitute a special risk for the subject.

Keywords: glycemic & insulin response, sds, cereal product, nutrition