Kornimate/medical-research-clean huggingface dataset:
pilot study of led for pie and pih

Conditions: Hyperpigmentation

Summary: the aim of this study is to explore the effect of medical leds (830 nm and 590 nm) in the prevention and treatment of pie and pih.

evidence regarding the efficacy of leds for post-inflammatory erythema (pie) and post-inflammatory hyperpigmentation (pih) is limited. the aim of this study was to evaluate the efficacy of 830 nm and 590 nm led phototherapies on pie and pih. design of the study: 308 nm led light (1.5 med) induced an in vivo pie/pih model on the thigh of ten healthy subjects. 830 nm (60 j/cm2) and 590 nm led (20 j/cm2) were irradiated respectively. for therapeutic irradiation, pie/pih model was induced on d1, and leds were irradiated on d0, 1, 3, 6 and 8. for preventive irradiation, leds were irradiated on d0, 1, 3, 6 and 8 and pie/pih model was induced on d9. erythema index (ei), melanin index (mi), transdermal water loss (tewl) and c-cube photography were measured during 10-day follow-up visits.

Eligibility criteria:
inclusion criteria: 1. healthy asians; 2. 20-65 years old; 3. fitzpatrick classification iii-iv; 4. sign the informed consent form. exclusion criteria: 1. have abnormal skin manifestations, such as pigment diseases, photosensitivity diseases and other allergic diseases; 2. those with a history of abnormal systemic diseases, such as heart disease, liver disease, kidney disease, tumors, and mental illness; 3. women who are preparing for pregnancy, pregnant or breastfeeding; 4. have used photosensitizing drugs within two weeks before inclusion in this study; 5. topical or systemic drugs may be used during this study; 6. bad habits, such as smoking, drinking, etc.; 7. volunteers who have recently participated in other clinical trials;

Keywords: photobiomodulation, pie, pih, led
the effect of virtual reality glasses on vital signs and state anxiety level in cancer patients

Conditions: Cancer Patients

Summary: this study was conducted as a non-randomized control group experimental study to determine the effect of virtual reality glasses on vital signs and state anxiety levels.

purpose this study was conducted as a non-randomized control group experimental study to determine the effect of virtual reality glasses on vital signs and state anxiety levels in cancer patients receiving chemotherapy for the first time. methods and sample the population of the study was composed of adult patients admitted to an oncology hospital in ankara province with a diagnosis of stage i-ii-iii cancer to undergo chemotherapy treatment for the first time. the sample of the study consisted of 30 patients who were assigned to the intervention and control groups by the stratified sampling method (considering such characteristics as age, gender, marital status). the patient identification form, spielberger state anxiety scale, patient opinion form, vital signs follow-up form, and virtual reality glasses were used to collect the data.

Eligibility criteria:
inclusion criteria: * diagnosed with stage 1,2,3 cancer * receive radiotherapy and chemotherapy for the first time * volunteer patients who agreed to participate exclusion criteria: -patients outside the inclusion criteria

Keywords: chemotherapy virtually reality anxiety nursing
the effect of oral health education on knowledge, attitude, practice and dental caries among egyptian school children

Conditions: Dental Caries in Children; Knowledge, Attitudes, Practice

Summary: aim of the study assessing the effect of an oral health education program on knowledge, attitude, practice, and dental caries among a group of school children in a governmental school in fayoum, egypt.

study type others: observational before and after study

Eligibility criteria:
inclusion criteria: * school children aged (6 to15) years old. * children with or without previous dental experience. exclusion criteria: * refusal of participation. * children with a mental or physical disability

Keywords: dental caries in children knowledge, attitude and practice dental caries experience oral health education
short-term effects kinesiotaping (kt) on balance and gait in parkinson's disease (dp)

Conditions: Parkinson Disease; Kinesiotaping

Summary: to analyze the short-term effect of kinesiotaping in balance and gait on parkinson's disease


Eligibility criteria:
inclusion criteria: * diagnosis of stage iii pd, according to the hoehn and yahr scale. * subjects who are in the age range of 50 to 80 years. * acceptance of informed consent. * not present a musculoskeletal disorder or other neurological disease that interferes with balance and / or walking. * not having a diagnosed vestibular disorder. exclusion criteria: * diagnosis of parkinsonism o parkison-like. * taking medications that may interfere with the different variables evaluated. * allergy to any component of the bandage. * being a pacemaker.
evaluation of bone mineral density changes after total hip replacement: a two-year clinical and dxa analysis

Conditions: Joint Disease

Summary: sponsor is conducting this post-market study to evaluate the clinical outcome and femoral bone mineral density (bmd) changes associated with the profemur® preserve hip stem when used as indicated for primary total hip arthroplasty in patients with osteoarthritis of the hip joint.


Eligibility criteria:
inclusion criteria: to be included in the study, subjects must meet all of the following criteria: * subject is minimum age 21 years, maximum age of 80 * subject is a candidate for primary tha for osteoarthritis of the hip * subject is able to undergo primary elective tha procedure * subject is willing and able to complete required study visits and assessments * subject is willing to sign the institutional review board/ethics committee (irb/ec) approved informed consent document. exclusion criteria: subjects will be excluded if they meet any of the following criteria: * overt infection; * distant foci of infections (which may cause hematogenous spread to the implant site); * rapid disease progression as manifested by joint destruction or bone absorption apparent on roentgenogram; * skeletally immature (less than 21 years of age at time of surgery); * inadequate neuromuscular status (e.g., prior paralysis, fusion, and/or inadequate abductor strength), poor bone stock, poor skin coverage around the joint which would make the procedure unjustifiable; * neuropathic joints; * known hepatitis or hiv infection; * neurological or musculoskeletal disease that may adversely affect gait or weight-bearing * subjects with known osteoporosis of the affected hip * subjects with prior arthroplasty of the affected hip * subjects that are clinically obese (\>40 body mass index \[bmi\]) * subjects with femoral dysplasia of the affected hip * subjects with trochanteric osteotomy of the affected hip * subject with inflammatory arthritis of the affected hip * subjects currently taking, or have taken within 12 months of enrollment, bisphosphonates, parathyroid hormone (pth), fluoride therapy or strontium ranelate or patients taking other chronic medications that in the investigator's opinion are known to affect bmd in a substantial way * subjects with severe medical condition(s) that in the view of the investigator prohibits participation in the study * subjects currently enrolled in another clinical study which could affect the endpoints of this protocol * subjects with known substance abuse issues * subjects who are incarcerated or have pending incarceration

Keywords: dual energy x-ray absorptiometry dexa dxa total hip arthroplasty profemur preserve bone mineral density bmd osteoarthritis tha musculoskeletal disease
study to test the efficacy and safety of drug eluting vs. bare-metal stents for saphenous vein graft interventions

Conditions: Coronary Artery Disease

Summary: prospective multicenter controlled randomized trial to compare the safety and efficacy of drug eluting vs. bare metal stents in percutaneous coronary interventions of saphenous vein grafts. hypothesis: survival and outcome will be significantly better in patients receiving des than in patients receiving bms regarding both short-term and long-term outcome.

research question: what is the effect of the paclitaxel eluting taxus® liberté® stent compared with the bare-metal liberté® stent (both boston scientific corporation, natick, ma) in saphenous vein graft (svg) percutaneous coronary interventions (pci) when used in conjunction with a glycoprotein iib/iiia inhibitor, e.g., abciximab (reopro®, eli lilly \& co., indianapolis, in), and a distal filter system? design: prospective, multicenter, controlled randomized trial. subjects: inclusion criteria: patients undergoing svg pci with a target vessel reference diameter ≤ 5.5 mm (visual estimate); documented silent ischemia, stable angina pectoris canadian cardiovascular society (ccs) class i to iv, or acute coronary syndrome. exclusion criteria: previous stent implantation anywhere in the target svg; concomitant native vessel pci; svg age \ 700x109/l; any major non-cardiac condition with a life expectancy \ 2 mg/dl.

Eligibility criteria:
inclusion criteria: * patients undergoing svg pci with a target vessel reference diameter ≤ 5.5 mm (visual estimate) * documented silent ischemia, stable angina pectoris canadian cardiovascular society (ccs) class i to iv, or acute coronary syndrome exclusion criteria: * previous stent implantation anywhere in the target svg * concomitant native vessel pci * svg age \<6 months * arterial grafts * oral anticoagulation * platelet count \ 700x109/l, white blood cell count \<3000 cells/mm3 * any major non-cardiac condition with a life expectancy \<12 months * planned elective surgery in the next 12 months * known allergies against the components tested * enrolled in other study * no consent * patients unlikely to comply to the study treatment and the follow-up visits * age \<18 years * known pregnancy
the efficacy and safety of transcutaneous auricular vagus nerve stimulation for anxiety in pd

Conditions: Parkinson Disease

Summary: this study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on parkinson's disease patients with anxiety. the investigators hypothesize that tavns will improve anxiety and cortical activity in parkinson's disease patients with anxiety.

participants in the experimental group underwent fourteen consecutive daily sessions of transcutaneous auricular vagus nerve stimulation (tavns, twice daily, 30 minutes each time) , whereas participants in the sham stimulation group underwent fourteen consecutive daily sessions of sham tavns. assessments of anxiety symptoms, motor symptoms were performed three times: at baseline, one day post intervention and 2 weeks post intervention. the cortical activity (using functional near-infrared spectroscopy) were assessed at baseline, one day post intervention.

Eligibility criteria:
inclusion criteria: * (1) diagnosed with idiopathic pd according to the movement disorder society clinical diagnostic criteria for pd; * (2) meeting diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) criteria for anxiety and hamilton anxiety scale (hama) score ≥ 12; * (3) stable pharmacotherapy for pd at least one month prior to the study; * (4) 40-80 years old; * (5) willing to sign written informed consent. exclusion criteria: * (1) with cognitive impairment, according to montreal cognitive assessment (moca) \< 23; * (2) took antianxiety drugs; * (3) with tavns contraindications; * (4) received vns treatment during the past month; * (5) with concomitant severe neurologic, renal, cardiovascular, or hepatic disease.

Keywords: parkinson's disease anxiety tavns
relationship between blood pressure and pulse wave velocity measurements in peritoneal dialysis

Conditions: End Stage Renal Disease; Peritoneal Dialysis; Arterial Sclerosis

Summary: this study evaluates the relationship between ambulatory aortic and branchial blood pressure vs office blood pressure measurements with the changes in arterial stiffness indices, in long-term peritoneal dialysis (pd) patients. these parameters will be monitored both cross-sectionally at the start of the study and prospectively over a 6 month period.

all participants will be monitored over a 6 month period during which 7 monthly visits will be performed. brachial and aortic blood pressure (bp), wave reflection and arterial stiffness indices will be assessed with the brachial cuff-based oscillometric device mobil-o-graph ng (iem, stolberg, germany). the above hemodynamic and arterial wall parameters will be measured for 24-hours on visits 1 (baseline) and 7 (month 6). the monitor will be set to obtain recordings 3 times/hour from 11:00 pm to 06:59 am and 2 times/hour from 07:00 am to 10:59 pm. measurements will be used for the analysis if \>80% of recordings were valid with no more than two non-consecutive day hours with fewer than two valid measurements, and no more than one night hour without valid recording, according to recommendations for ambulatory bp monitoring. bioelectrical impendance analysis (bia) with the fresenius body composition monitor (bcm - fresenius medical care, bad homberg, germany) will be performed on visits 1, 4 and 6 in order to assess the hydration status and body composition parameters of the participants.

Eligibility criteria:
inclusion criteria: 1. age 18 years old or higher 2. renal replacement therapy with peritoneal dialysis (automated or continuous ambulatory) for at least 3 months prior to study enrollment 3. patient to have provided informed written consent exclusion criteria: 1. ongoing atrial fibrillation 2. hospitalization for acute myocardial infarction, unstable angina or acute ischemic stroke within the 3 previous months 3. recent episode of pd-related peritonitis or exit site infection 1 month or less prior to study enrollment 4. bilateral functioning or non-functioning arteriovenous fistula (avf) and/or arteriovenous graft (avg) used earlier for dialysis access in patients previously treated with hemodialysis 5. body mass index (bmi) of \>40 kg/m2 6. history of malignancy or any other clinical condition associated with very poor prognosis

Keywords: arterial stiffness pulse wave velocity peritoneal dialysis
coblation versus cold adenoidectomy -safety and efficiency

Conditions: Sleep Apnea, Obstructive

Summary: comparative two methods of adenoidectomy means the coblation adenoidectomy with the cold dissection adenoidectomy specifically inquire which method is safer and more efficient.

obstructive sleep apnea(osa) in children is a very bother and frequent problem with clinical and behavioral impacts. the hypertrophied adenoid tissue obstructs the air way in the nasopharynx that initiates the common symptoms. the treatment from that concerning problems is in the operation rooms by diversity surgical methods, the very older one is the cold dissection adenoidectomy. recently many surgeons use the coblation system as a preferred method for adenoidectomy. this method was proof as a safe and efficient especially referring to the bleeding and the dehydration risk . many children that operated by the cold dissection forced to perform another one or two operations presumably due to the adenoid tissue that did not removed completely from the first operation . our hypothesis is that the coblation systemis a safe and eficient method for adenoidectomy. the aims of this project is to verify if our theory is corect by blinded comparision between two methods.

Eligibility criteria:
inclusion criteria: * children with obstructive symptoms * the children must perform nasopharyngoscopy with clear evidence of obstructive symptoms ( video or polysomnography more than 5 rdi) exclusion criteria: * without any recent upper respiratory tract infection or clinical suspicious of adenoiditis. * tonsillectomy * non randomalization, not blinded
traditional chinese medicine formula in the treatment of osteoarthritis of knees or hips.

Conditions: Osteoarthritis

Summary: to investigate the efficacy and safety of oa1 extract capsules in the treatment of patients with knee or hip osteoarthritis (oa).

this trial was a 12 weeks' randomized, double-blind, placebo-controlled study. the study was approved by the institutional review board of chung shan medical university hospital, and signed informed consent was obtained from each patient. sixty patients of osteoarthritis of knees or hips were enrolled in this study. inclusion criteria were: age 20 to 80 years; primary osteoarthritis in at least 1 knee or hip, verified; at least moderate pain during 2 weeks before random assignment to treatment, as identified by the western ontario and mcmaster universities (womac) lk3.0 osteoarthritis index pain subscale for more than 4. primary outcome measures were womac at week 12. secondary outcome measures were womac at week 4 and 8; visual analogue scale (vas) , quality of life by sf-36, patient global assessment (pga), at week 4, 8 and 12; serum levels of osteocalcin, c-terminal telopeptide(ctx), hs-crp, and esr.

Eligibility criteria:
inclusion criteria: * 1. age ≥20 years old 2. written informed consent obtained 3. been diagnosed with knee or hip osteoarthritis 4. the physician interpretation of x-ray identification and joint space narrowing or bone spurs confirmed 5. in randomized trials before entering if used steroids or non-steroid medications osteoarthritis stable doses required at least one week 6. the womac osteoarthritis index of the degree of pain assessment in the past two weeks at least\> 4ppm pain exclusion criteria: * 1. pregnant or breast-feeding women. 2. chemotherapy or radiation therapy in cancer patients
negating opioid and pain actively through intervention

Conditions: Pain; Chronic Pain; Opioid Use

Summary: chronic pain is one of the most prevalent and debilitating medical conditions and opioid analgesics are a commonly prescribed class of medications in the united states. opioid efficacy has been proven in terms of managing acute and chronic pain; however, opioid overdose deaths, addictions, and diversions have all continued to increase over the years. the purpose of this study is to increase patient engagement in pain management and education, and to decrease opioid use by 10% over the study period. this study will also help present opportunities for future studies to obtain insight regarding the chronic use of opioids.

the institutional review board has approved this prospective single-center study at a large 900-bed academic university medical center. the electronic medical record system will identify 300 patients, who are at least 18 years of age, with a history of opioid use for 3 or more months, or who are currently prescribed and are using long-acting or extended release opioids. procedures by student pharmacists, pharmacy residents, and pharmacists will include reviewing medical records and prescription drug monitoring programs for the use of opioids, evaluating baseline pain, quality of life, and satisfaction via questionnaires and assessment questions, and performing thorough medication consultations on current opioid regimens. education of pain and promotion of adjunct and non-pharmacologic alternative therapies will be completed to engage patients in assessing their pain and seeing the effectiveness of their treatment. patients will receive 3 follow-up interventions: 2 phone calls with a pharmacist or student pharmacist at weeks 2 and 6, and a follow-up visit with a pain or primary care physician. opioid usage, pain, quality of life, and patient satisfaction will be assessed. the primary outcome measured will be a decrease in opioid usage in morphine milligram equivalents. secondary outcomes include change in quality of life and patient satisfaction.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * history of opioid use for 3 or more months or * currently prescribed and are using long-acting or extended release opioids exclusion criteria: * substance use * oncology patients * hematology patients

Keywords: pain opioid drug monitoring pain education
risk early warning management for postoperative hip fracture rehabilitation and delirium prevention in elderly patients

Conditions: Hip Fractures (ICD-10 72.01-72.2)

Summary: this clinical study aims to evaluate the effectiveness of a perioperative risk early warning management strategy in patients undergoing surgical treatment for hip fractures. hip fractures are common in elderly individuals and are associated with a high risk of postoperative complications. traditional perioperative care may not sufficiently identify and respond to early signs of clinical deterioration. in this study, patients with hip fractures admitted to the orthopedic department of a single hospital from january 2023 to december 2023 were divided into two groups based on their admission time. patients admitted between june and december 2023 received the early warning risk management intervention (experimental group), while those admitted between january and may 2023 received routine perioperative care (control group). the early warning management system involved a scoring-based approach using vital signs such as heart rate, respiratory rate, blood pressure, body temperature, and consciousness level to classify patients' risk levels. nursing staff responded with graded interventions, including enhanced monitoring and rapid physician notification for higher-risk patients. the study retrospectively enrolled 284 patients in total, with 142 in each group. the primary outcomes include changes in coagulation function, self-care ability (measured by the exercise of self-care agency scale, esca), and hip joint functional recovery (measured by the hospital for special surgery, hss, score). secondary outcomes include patient satisfaction and incidence of postoperative complications. the central hypothesis is that perioperative risk early warning management will improve patient safety, enhance self-care capacity, reduce complications, and promote better recovery outcomes compared to routine care.


Eligibility criteria:
inclusion criteria: * diagnosed with unilateral intertrochanteric fracture of the femur confirmed by imaging. * age 18 years or older. * met the indications for surgical treatment and underwent fracture surgery in the study hospital. * stable vital signs and clear consciousness postoperatively. exclusion criteria: * presence of hematologic diseases such as coagulation dysfunction. * existing lower limb disability, invasive trauma, or other comorbid lesions. * history of mental disorders, cognitive impairment, or poor compliance with treatment protocols.

Keywords: risk early warning management hip fracture rehabilitation postoperative delirium prevention proximal femoral nail (pfn) surgery elderly orthopedic patients blood coagulation function self-care ability retrospective cohort study
sotrovimab expanded access treatment protocol (covid-19)

Conditions: Covid19

Summary: an expanded access program for sotrovimab administered intravenously to participants with covid-19 illness who meet current authorized/approved criteria for use of sotrovimab.


Eligibility criteria:
inclusion criteria: * in the opinion of the investigator, meets the current emergency use authorization (eua) eligibility criteria for sotrovimab or * patients currently hospitalized for a non-covid-19 illness who acquire covid-19 (nosocomial infection) and otherwise meets all the current eua eligibility criteria exclusion criteria: * hospitalized due to covid-19 (excludes nosocomial infection) * require oxygen therapy due to covid-19, or who require an increase in baseline oxygen flow rate due to covid-19

Keywords: sars-cov-2 coronavirus coronavirus disease 2019 covid-19