Kornimate/medical-research-clean huggingface dataset:
the effects of stainless steel crowns applied with hall technique on occlusal vertical dimension

Conditions: Caries, Dental

Summary: in recent years restoring carious of fractured primary teeth with stainless steel crowns (ssc) has became more popular than ever. on the other hand the traditional operative approach of complete removal of caries is steadily losing support due to successful results with materials of high microleakage resistance. treatment time and pain control in asymptomatic teeth has always been a problem in children. hall technique is a minimally invasive treatment protocol that doesn't require local anesthesia, use of rotating devices for caries removal to restore primary teeth with ssc. but this protocol also raised questions in the scientific community about its possible effects on the dentition and temporomandibular joint (tmj) for causing primary occlusal contact and increasing vertical dimension. the aim of our research is to study the effects of hall technique's premature occlusal contact on tmj.


Eligibility criteria:
inclusion criteria: * no systemical illness * willing to come to control appointments * no symptoms of pulpal inflammation * to have at least 1, 3 at most dentin caries primary teeth without infection, mobility, angle class i profile and molar relation * willing to participate the study exclusion criteria: * history of diagnosed systemic illness * anterior/ posterior crossbite * presence of dental pain * root resorption exceeding 2/3's of the treated tooth * gingival inflammation, periodontal disease * signs of parafunctionism, bruxism * facial asymmetry * signs or symptoms of temporomandibular disfunction * not willing to participate

Keywords: hall technique stainless steel crowns temporomandibular joint dental caries occlusion
serotoninergic pathways in sudden and unexpted death in epilepsy (sudep)

Conditions: Sudden Unexpected Death in Epilepsy (SUDEP)

Summary: the mortality rate is increased in patients with epilepsy, and especially among patients with drug-resistant epilepsy. this increased mortality is mainly related to the risk of sudep whose incidence is between 3.5 and 9 per 1,000 for patients with drug-resistant epilepsy. the term sudep refers to a sudden death occurring in a patient with epilepsy in whom anamnestic and post-mortem evidence does not identify a particular cause. experimental and clinical data strongly suggest that most of sudep result from a postictal respiratory dysfunction progressing to terminal apnea. due to the major role of serotonin in regulating breathing rhythms and data in animal models of epilepsy, it is envisaged that an alteration of serotonergic systems of the brainstem and limbic regions may play a central role in the occurrence of sudep. the objective of this work is to look for abnormalities of the serotonergic transmission within regulatory regions of respiratory and autonomic functions in brain samples prospectively collected in patients died from sudep.


Eligibility criteria:
inclusion criteria: * age \>18 years * postmortem time before autopsy \<30 hours exclusion criteria: * age \<18 years * postmortem time before autopsy \> 30 hours * any subject whose brain would be of forensic interest * any patient who expressed an opposition to organ donation.

Keywords: epilepsy sudep serotonin
meditation based lifestyle modification in chronic pain

Conditions: Pain, Chronic

Summary: mblm is a holistic therapy for people with mental disorders whose feasibility positive effects on patients with depression have already been demonstrated in clinical application and a piloted study. in the present trial, the feasibility and effect of mblm on patients with chronic pain will be investigated.

mblm expands existing concepts of mind-body medicine with ethical and spiritual concepts from the traditional patanjali yoga system, which can act as a coping factor on the one hand, and higher motivation and deepening of self-administered practice (mindfulness based exercises, body-oriented yoga exercises and mantra meditation). mblm aims to establish an exercise routine in the daily lives of the participants, which leads to salutogenesis. the promotion of mental health through meditation and yoga has been well documented, also in clinical populations. the effects of meditation and yoga on addiction and pain are promising, but there is still a need for research. furthermore, the preventive potential of the mblm program will be examined for healthy volunteers, analogous to the already well-researched and widely used mbsr (mindfulness based stress reduction) program, which was originally also developed for patients with pain disorders. the study will be conducted as an experimental single case analysis with multiple baseline design. randomization takes place over time instead of control groups.

Eligibility criteria:
inclusion criteria: 1. outpatients 2. current diagnosis of a chronic pain disorder. 3. over 18 years old. 4. physically able to perform simple yoga postures and sit for 20 minutes. 5. have given your written consent to participate in the study. exclusion criteria: 1. psychotic symptoms 2. acute suicidality 3. obsessive-compulsive disorder 4. cerebro-organic diseases with clinically relevant symptoms 5. severe multimorbidity 6. current participation in another meditation or yoga study 7. regular meditation or yoga practice (\> once a week in the last 6 months)

Keywords: yoga meditation yoga philosophy mantra mind-body
3d printed advanced cardiac models for transseptal puncture, cardiac ablation, and cardiac tamponade simulation training

Conditions: Satisfaction, Personal

Summary: the objective of this study is to develop advanced cardiac models using 3d printing technology for teaching complex cardiology procedures such as (1) transseptal puncture, (2) cardiac ablation, and (3) ultrasound scanning and drainage of cardiac tamponade. by implementing this study, the investigators aim to transform the teaching methods for cardiology students at our hospital.

background： the standard methodology for education in medicine, particularly in cardiology, still follows the apprenticeship model, where trainees observe, gradually take over, and practice under supervision until they can independently perform procedures. the traditional pedagogical strategy for complex medical procedures, like cardiac catheterization, emphasizes the "see one, do one, teach one" doctrine. studies have revealed the superior efficacy of 3d printing in medical education, particularly in enhancing learning skills and knowledge among medical students. the demand for 3d printed models in medical education is increasing continuously. study design： this study is a single-center, pilot, prospective, randomized controlled educational trial. methods： the trial will be conducted in the department of cardiovascular medicine at fu jen catholic university hospital. the investigators plan to enroll 50 participants, who will be randomly assigned to either the 3d model training group (n=25) or the conventional curriculum group (n=25) in a 1:1 ratio. all participants will undergo pre- and post-training assessments, including a knowledge test (structured written questionnaire), an attitude assessment (semi-structured satisfaction questionnaire), and a skills evaluation (direct observation of procedural skills, dops). effect： the investigators anticipate the development of a set of advanced 3d cardiac models for teaching cardiology procedures. it is expected that combining classroom learning with the viewing and interactive practice of 3d printed models will significantly improve the learning outcomes of the trainees. key words： clinical simulation-based education, advanced cardiology procedures, transseptal puncture, cardiac ablation, cardiac tamponade.

Eligibility criteria:
inclusion criteria: * medical student, nurse practitioner and resident in fu jen catholic university hospital exclusion criteria: * refused to participate in the study.

Keywords: clinical simulation-based education advanced cardiology procedures transseptal puncture cardiac ablation cardiac tamponade
systems of support study for childhood depression

Conditions: Depression

Summary: this study is designed to compare two treatments for depression in pre-adolescent (7-13 year old) children. a family-focused treatment will be compared to an individual child-focused treatment in this 14-week intervention.

childhood-onset depression is an impairing and often recurrent and persistent disorder that impacts current and later development resulting in high personal, social, and economic costs. despite the costs of early-onset depression, the emphasis in current practice parameters on an initial course of psychosocial treatment, and extensive research on adolescent depression, we currently lack randomized controlled trials evaluating psychosocial treatments for children with depressive disorders. the present proposal aims to address this gap in knowledge regarding optimal psychosocial treatment strategies for children suffering from depressive disorders. we propose a 2-site randomized controlled trial to evaluate the efficacy of family focused treatment (fft), as compared to an individual client-centered psychotherapy (ip) modeled after "usual" community care. fft adopts an interpersonal model for understanding how depressive symptoms are maintained, emphasizes developing family skills/strategies for altering interpersonal processes, and works on building a family environment that supports recovery and enhances stress resistance and resilience. this approach may be particularly appropriate to the developmental needs of depressed children, given their dependence on parents, the potential of fft to address the needs of multiple family members, and our data supporting benefits on depression, functioning, and other co-occurring symptoms. the proposed project will enroll 140 children (ages 8-12) with depressive disorders. children will be randomly assigned to receive a 14-week trial of either fft or ip. at study entry, immediately post-treatment, and at a 9-month post-treatment follow-up all participants will undergo intensive evaluation of clinical state and psychosocial and family functioning.

Eligibility criteria:
inclusion criteria: * current depressive disorder * ages 7-13 years * living with at least one biological parent willing to participate exclusion criteria: * thought disturbance * severe conduct disorders * unstable on antidepressant medications * continuation in current non-study treatment * non-english speaking

Keywords: depression, children, adolescent, family
cerebrolysin and neurodevelopment in preterm infants

Conditions: Infant Development; Cerebral Palsy; Preterm Infant

Summary: the overall aim of the study is to assess the effect of cerebrolysin on physical and mental development of preterm infants by denver scale ii at different ages of 5, 7 and 12 months

there is an inverse relationship between birth weight or gestational age and risk for developmental impairment, with increasing incidence as birth weight or gestational age decreases. serious impairment, defined as problems in body function or structure which may be temporary or permanent, is generally a more stable condition and typically leads to a disability requiring rehabilitation. mild impairment is a more reversible condition amenable to early intervention. studies that have followed extremely preterm and extremely low birth weight infants into school age and early adulthood have shown higher rates of motor, cognitive or behavioral impairments as compared with infants born at term. the neurologic consequences of extreme prematurity range from mild behavioral and cognitive defects to severe disability. perinatal neuroprotection aims to reduce these outcomes. cerebrolysin is a porcine brain-derived peptide preparation that acts like endogenous neurotrophic factors. it is produced by a standardized enzymatic breakdown of lipid-free brain protein powder and consists of low molecular weight peptides and free amino acids. the pharmacodynamic effects of cerebrolysin can be categorized in terms of neuronal survival (e.g. trophic and survival promoting actions), neuroprotection (e.g. limiting neuronal dysfunction, especially in adverse conditions), neuroplasticity (e.g. adaptive responses to changing conditions) and neurogenesis (e.g. promoting differentiation of progenitor cells). we aim to assess the effect of cerebrolysin on physical and mental development of preterm infants at different ages of life at 5, 7 and 12 months.

Eligibility criteria:
inclusion criteria: * high risk preterm infants born with gestational age less than 32 weeks and have a corrected postnatal age of 5 months at time of enrollment. included preterm infants should have one or more of the following risk factors which may affect their neurodevelopmental outcome. 1. infants diagnosed with bronchopulmonary dysplasia requiring oxygen therapy more than 30% fio2 at 36 weeks corrected gestational age. 2. infants with culture proven early or late onset neonatal sepsis with or without neonatal meningitis. 3. infants diagnosed to have peri- ventricular leukomalacia diagnosed by brain imaging. exclusion criteria: 1. patient with persistent uncontrolled fits (all possible reasons for these uncontrolled seizures, including non-epileptic seizures, pseudo intractability, and medically refractory epilepsy. 2. patient with brain malformation.
neuroimaging & plasma markers for predicting outcomes after mild traumatic brain injury

Conditions: Traumatic Brain Injury; Injury of Body Region

Summary: this exploratory study aims to identify the most promising biomarkers that alone or in combination might predict development of mood disorders \[i.e., major depression (md\], cognitive disorders \[i.e., executive function deficits (efd)\], and functional impairment following repetitive/mild traumatic brain injury (mtbi).

this will be a prospective study of subjects with mtbi, body injury and healthy controls. subjects who meet the study criteria will be enrolled in the study after they provide informed consent. all subjects will be followed longitudinally at 3 and 6 months post-injury. all subjects will have 3-4 visits: screening visit to determine eligibility; first study visit within 1 month of injury for those with brain or body injury (at the time of screening or within 1 month of screening for healthy controls); second study visit at 3 months post-injury (3 months after the first visit for healthy controls) and third study visit at 6 months post-injury (6 months after the first visit for healthy controls).

Eligibility criteria:
inclusion criteria: individuals with mtbi: inclusion criteria: 1. have sustained a closed head injury, defined as externally inflicted trauma without skull fracture; 2. have a glasgow coma scale (gcs) score 13 or above 3. meet the american congress of rehabilitation medicine criteria for mild traumatic brain injury 4. have experienced the last injury within 1 month 5. be in excellent/good medical health as assessed by the general medical health rating (gmhr) scale 6. have sufficient cognitive capacity to provide informed consent 7. be between 18-65 years of age and 8. be willing to have brain mri and a blood draw, individuals with body injury will meet inclusion criteria 4-8. instead of criteria for head injury (1-3) they would have had body injury (defined as injury below the neck (e.g., limb fractures, stab wound abdomen). age, and sex, matched normal controls: inclusion criteria: 1. no history of head injury or any other types of brain injury 2. inclusion criteria 5-8 exclusion criteria: 1. history of stroke, seizures or other pre-injury neurological diseases 2. mental retardation 3. history of skull fracture 4. presence of severe unstable medical disease 5. contraindications to the mri brain scan 6. possibility of pregnancy 7. presence of communication difficulties, such as moderate to severe hearing or language impairment.
how does implementing a getup assist device in addition to a daily low-intensity functional or traditional training program affect norwegian female office workers' physical health after 12 weeks?

Conditions: Neck, Shoulder and Arm Syndrome

Summary: this study aims to quantify the effect of daily transition routines between sitting and standing behaviour with an additional daily low-intensity traditional or functional training program on the physical health of sedentary norwegian female workers after 12 weeks of implementation into their working environment.


Eligibility criteria:
inclusion criteria: * females are included in this study due to the approximately twice-high prevalence of work-related musculoskeletal disorders. * no experience with office fit training or participation in an ongoing similar training intervention is allowed. * working more than 6 hours a day at a computer workstation * physical inactivity (less than two sessions or bouts of exercise totalling 30 minutes/week). * musculoskeletal complaints are accepted as long as the pain is not a restricting factor. when performing the testing and training intervention exercises. exclusion criteria: * participants not able to perform the testing battery.
dexmedetomidine alleviates postoperative delirium after brain tumor resections

Conditions: Dexmedetomidine; Postoperative Delirium

Summary: postoperative delirium (pod) is a common complication, and the incidence rate is about 25% in non cardiac surgery. previous studies have reported that the total incidence of neurological pod ranged from 10% to 22%. dexmedetomidine (dex) is an a-2 adrenergic agonist for sedation. this kind of drug has little effect on respiratory function, is easy to wake up and has analgesic effect. it is a commonly used perioperative adjuvant drug. however, for neurosurgical patients with brain tumors, the role of dex in pod is not clear. the purpose of this study was to investigate the effect of dex on pod in neurosurgical brain tumor surgery.


Eligibility criteria:
inclusion criteria: * patients undergoing selective frontotemporal tumor resection. * age ≥18 years. * obtain written informed consent. exclusion criteria: * refusal to provide written informed consent. * preoperative severe cognitive impairment (mini-mental state examination, mmse ≤ 20). * allergic to the study drug. * history of psychotropic drugs within past 30 days. * pregnant or lactating women. * history of traumatic brain injury or neurosurgery. * severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block. * severe hepatic or renal dysfunction.
abdominal computed tomography and the blood reactive oxygen species level

Conditions: Radiation Injury

Summary: the clinically widely used x-ray computed tomography examination has a low-grade radiation effect and recently has attracted much attention concerning the possible adverse effects of radiation on human body \[ref. 1-5\]. the radiation is harmful to human tissues and cells mainly because it can interact with water (which makes up to 80% of cells) to generate reactive oxygen species (ros), especially the formation of hydroxyl radicals. so far as we can reach, there is no report concerning the relation between x-ray computed tomography examination and the blood ros level. therefore, we wish to conduct this study to clarify if the routinely applied abdominal x-ray computed tomography examination may induce a higher level of ros in the peripheral blood. study subjects will be patients who are admitted to our hospital because of abdominal diseases that need to receive abdominal x-ray computed tomography examination for diagnosis. in total, sixty cases will be enrolled for the study. the formal consent will be delivered and explained to the patients and families several hours before the performance of abdominal x-ray computed tomography. the formal consent will be retrieved and then the peripheral blood will be sampled just before the performance of computed tomography.ros level in the sampled peripheral blood, before and after the performance of abdominal x-ray computed tomography, will be measured, compared, and analyzed. totally 120 blood samples, including 60 samples just before and 60 samples 2 hours after the performance of computed tomography, will be collected from 60 study subjects within 5 months (august 10 \~ december 30, 2008). reactive oxygen species（ros）levels will be measured by a chemiluminescence (cl) analysing system (cld-110, tohoku electronic industrial, sendai, japan).


Eligibility criteria:
inclusion criteria: * patients with abdominal illness that needs a computed tomography examination exclusion criteria: * none

Keywords: radiation injury computed tomography reactive oxygen species free radicals
dry needling treatment for knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: the population affected by degenerative knee arthritis is very large. the investigator performed dry needle (dn) treatments with acupuncture needles. this experiment used a randomized single-blind experiment to assess the immediate, short-term and long-term effects of dry needle therapy on patellar pain in patients with degenerative arthritis.

the population affected by degenerative knee arthritis is very large. according to a survey conducted by the ministry of health and welfare, the prevalence of osteoarthritis of the knee in taiwan is about 3.5 million people, accounting for about 15% of the total population. its effects are a heavy burden on socio-economic costs, and in addition to being included in medical expenses, serious cases can lead to incapacity to work; therefore, the disease is an important factor in causing disability and disability first, it is worth our attention. the investigator performed dry needle (dn) treatments with acupuncture needles. stimulating the effected muscle, the investigator move the needle forward and backward several times. muscle twitch may occur by our procedure. the pain caused by myofascial trigger points can be decreased effective simultaneously. so far, there is no solid research or clinical trial to evaluate the efficacy of the treatment yet. for the reasons of the degenerative arthritis pain, the clinical observation is not entirely due to the cause of joint deformity or cartilage damage, soft tissue lesions around the knee is also a common source of pain, the use of dry needle for the diagnosis of soft tissue injury , and observed its efficacy, which is also the core of this study. this experiment used a randomized single-blind experiment to assess the immediate, short-term and long-term effects of dry needle therapy on patellar pain in patients with degenerative arthritis. the assessment tools included the vas, womac , lequesnes index, gait speed test and the muscle tension changes in the lower extremities.

Eligibility criteria:
inclusion criteria: 1. volunteers who are older than 50 years old and can cooperate with the experiment 2. established diagnosis of unilateral or bilateral degenerative knee arthritis. 3. there is a local trigger point around the unilateral or bilateral knee joint which on the muscle of vastus lateralis, vastus medialis, gastrocnemius, or tibialis anterior. exclusion criteria: 1. there are contraindications to general treatment, such as serious medical problems, recent serious trauma, or pregnant women. 2. there has been a history of drug abuse (including excess alcohol) that affects pain assessors. 3. have received knee surgery. 4. people with central or peripheral nerve disease. 5. cognitive impairment, unable to cooperate with the experimenter. 6. patients currently receiving other treatments for knee osteoarthritis

Keywords: dry needling myofascial trigger point muscle tone