Kornimate/medical-research-clean huggingface dataset:
rates and severity of ponv for neuromuscular block reversal in patients receiving gastric bypass bariatric surgery

Conditions: Bariatric Surgery Candidate

Summary: patients who require bariatric surgery frequently bring a panoply of pre-existing comorbidities to the operating theatre. with body mass indices routinely in the 50s and 60s, patients who have bariatric surgery frequently have postoperative and post-discharge nausea and vomiting (ponv and pdnv)

there are many causes of post-operative nausea and vomiting in bariatric patients. these include (but are not limited to) the following: 1) mechanical manipulation of the stomach and bowel, 2) post-surgical inflammation of the tissue just operated on, 3) vagal stimulation of the viscera, 4) the administration of volatile anesthetics, 5) the administration of narcotics, 6) the underlying propensity of patient's for post-operative nausea and vomiting, based on prior history, gender, and other factors and 7) the administration of a cholinergic medication for muscle relaxant reversal. from previous work, it is known that alternate techniques are available to mitigate factors two through four, and patient screening has been available to help us determine the likelihood of patients becoming nauseous or vomiting postoperatively (factor #5). however, until the advent of sugammadex, there has been no alternative to factor 6. the use of sugammadex as a reversal agent could dramatically lower the incidence of ponv, while simultaneously providing an excellent level of reversal of neuromuscular blockade. there have been no published studies that have described laparoscopic gastric bypass, sleeve gastrectomy or duodenal switch procedures where complete prevention of ponv has been the result. a secondary objective will be the comparison of pulmonary function before and after surgery between the same two groups. in patients having gastric bypass surgery, not only does ponv aggressively aggravate the tissues which were just surgically manipulated, it also increases the likelihood of decreased ventilatory response, placing patients at risk for aspiration, atelectasis, pneumonia and respiratory failure.

Eligibility criteria:
inclusion criteria: * • \> 18 to \<= 70 years of age * severe obesity requiring bariatric surgery * willing and able to give informed consent, or if appropriate, have a legally authorized representative capable of giving consent on the participant's behalf * willing to perform the fvc breathing test * willing to be contacted at home via phone exclusion criteria: * • \ =70 years of age * no pregnant patients will be enrolled * patients with documented allergies to anesthesia agents or histories of malignant hyperthermia will not be enrolled. * participants must be eligible to receive elective bariatric surgery * participants who are discharged to skilled care facilities rather than home will not be considered for participation * lacking capacity to provide informed consent * prisoner
perceived stress and negative thoughts with biomarkers in people with type 2 diabetes mellitus and healthy subjects

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to determine the effect of measured and induced negative feelings on glucose, tumor necrosis factor alpha, and cortisol levels in healthy participants and participants with type 2 diabetes mellitus.

depression and diabetes are two pathologies that are frequently comorbid. stress and negative thoughts are part of both. the biological correlates of psychological and emotional life are not yet fully clarified, so in this study we wonder about the association between tumor necrosis factor alpha, cortisol, and peripheral glucose levels with depression stress, measured negative thoughts, and induced guilt.this is a randomized intervention study. at baseline, participants complete the beck depression inventory, the automatic negative thoughts scale (atq-n), and the perceived stress scale (pss-14). the intervention consists of a written task about situations that involved feelings of guilt or neutral situations. saliva and dextrostix samples are taken before the 20-minute written task, at the end, dextrostix and saliva samples are performed again, finally a blood sample is taken.

Eligibility criteria:
inclusion criteria: * written, informed consent. * 30 to 65 years of age. * current diagnosis of diabetes mellitus type 2 without diabetic foot. * healthy volunteers. * ability to read and write. exclusion criteria: * other current or past chronic disease diagnoses. * current use of antidepressants or other psychiatric medications. * steroid medication. * consumption of tobacco or alcohol in the last 24 hours. * previous diagnosis of autoimmune diseases

Keywords: diabetes depression stress negative thoughts
a study to assess the effect of linezolid on qtc interval

Conditions: Bacterial Infections

Summary: the fda has asked pfizer to assess the risk of linezolid on qt interval (obtained from ecg readings) which could predispose patients to ventricular arrhythmias. this study is conducted to satisfy this requirement.


Eligibility criteria:
inclusion criteria: * healthy male and female subjects between the ages of 21 and 55 years. * body mass index (bmi) of 18 to 30 kg/m2; and a total body weight \> 45 kg (99 lbs). * an informed consent document signed and dated. exclusion criteria: * evidence or history of clinically significant abnormality. * 12-lead ecg demonstrating qtc \>450 msec at screening. * receiving selective serotonin reuptake inhibitors (ssris) and/or sympathomimetic agents. * abnormal liver function tests. * a positive urine drug screen, history of excessive alcohol and tobacco use.

Keywords: linezolid, qtc interval, pharmacokinetics, therapeutic dose, supra-therapeutic dose
target attainment of tdm-guided infusion of piperacillin/tazobactam and cefepim in critically ill patients

Conditions: Critical Illness; Antibiotic Toxicity; Sepsis; Septic Shock

Summary: although alternative dosing strategies can improve antimicrobial exposure in critically ill patients, the high pk variability in this population means that some may still receive sub-optimal antibiotic exposure leading to unfavourable clinical outcomes. therapeutic drug management (tdm) guided dosing is the only safe and effective way to ensure that all critically ill patients achieve therapeutic antimicrobial exposures and to minimise the likelihood of toxicity. for experts, tdm should be a standard of care, in particular for β-lactams. nevertheless, because of the assay method for β-lactams and the need for bioanalytical experts, delays in obtaining results frequently occurred. these barriers, combined with difficulties in the interpretation of tdm results, need to be addressed in order to increase its routine utilization. consequently, study aiming at identify which subgroup of patients or infection are more likely to benefit from tdm are urgently warranted this prospective observational study aimed at evaluating target attainment of piperacillin/tazobactam (pip/taz) and cefepim (cef) with the use of a therapeutic drug monitoring (tdm) in critically patients during the routine care


Eligibility criteria:
inclusion criteria: * minimun age limits 18 years * critically ill patient receiving piperacillin or cefepim administered continuously exclusion criteria: * beta lactam allergy * pregnancy * age less than 18 years

Keywords: therapeutic drug monitoring
phase iii clinical trial of stsp-0601 for injection in hemophilia patients

Conditions: Hemophilia

Summary: this study will assess the efficacy of multiple-dose of stsp-0601 for the treatment of bleeding episodes in hemophilia a or b patients with inhibitor


Eligibility criteria:
inclusion criteria: 1. 12 ≤age≤70 years of age. 2. hemophilia a or b patients. 3. peak historical inhibitor titer ≥ 5 bu and a positive inhibitor test when enrolled. 4. establish proper venous access. 5. there were at least 3 bleeding events that required treatment occurred in the past 6 months before screening. 6. agree to use adequate contraception to avoid pregnancy. 7. provide signed informed consent. exclusion criteria: 1. have any coagulation disorder other than hemophilia. 2. plan to receive prophylactic treatment of coagulation factor during the trail. 3. patients plan to receive emicizumab during the trial. 4. patients received anticoagulant or antifibrinolytic therapy 7 days before the first administration or plan to receive these drugs during the trial. 5. have a history of arterial and/or venous thrombotic events. 6. platelet \<100×109/l. 7. hemoglobin\<90g/l. 8. severe liver or kidney disease. 9. severe bleeding event occurred within 4 weeks before the first administration. 10. accepted major operation or blood transfusion within 4 weeks before the first administration. 11. have a known allergy to stsp-0601. 12. pregnant, lactating, or blood pregnancy test positive female subjects 13. participate in other clinical research within 4 weeks before enrollment (except for participating in prothrombin complex, fvii, fviia, fviii, fix trails). 14. within 1 day before the first administration, fvii, fviia, tranexamic acid, and aminocaproic acid were used. within 3 days before the first administration, prothrombin complex, fviii, and fix were used. within 4 weeks, treatment with emicizumab was received. 15. patients not suitable for the trail according to the judgment of the investigators.
burden of cervical cancer in tanzania

Conditions: Cervical Cancer; -Socioeconomic Burden of Disease

Summary: cervical cancer screening is a worldwide problem especially in the developing world of which tanzania belongs. it is diagnosed late in the third world because there are no diagnostic facilities and resource people. it occurs in the age groups between 40 and above and therefore affects the productive age of the community. it is well known that women generally are the backbone of every community and specifically in the developing countries. the objective of this research is to analyze and quantify the burden of cervical cancer disease in the community. it will research the interpersonal and socioeconomic issues associated with cervical cancer disease in the family.


Eligibility criteria:
inclusion criteria: * new pathological diagnosis of cervical cancer exclusion criteria: * non consenting individuals
the effectiveness and cost-effectiveness of medical advice given by telephone for patients calling for primary care

Conditions: Isolated Fever; Gastroenteritis Symptoms

Summary: telephone medical advice in general practice is expanding. the cochrane database concludes in 2008 that there is not enough data about its use regarding out-of-hours general practitioners workload, emergency department visits, cost, safety and patient satisfaction. the aim of this study is to assess the effectiveness of telephone medical advice given by a general practitioner in a call centre for patient presenting isolated fever or gastroenteritis symptoms.

this is a prospective, open label, cluster randomized trial of 2 880 expected patients who calling a french emergency medical service dial 15 for fever or gastroenteritis symptoms during out-of-hours periods. all calls will be taken by a general practitioner (gp). out-of-hours period is defined as 8 pm to 8 am on weekdays, 1 pm to 8pm on saturdays in addition to sundays and holidays.to be exhaustive, we will enrol patients during one year. in the experimental arm, the gp will implement a protocol of care to each patient call. the protocol includes medical advice, drug prescription by phone and supervisory board. patients are invited to recall in case of worsening or onset of new symptoms and to get an appointment with their gp during working hours. in the non-interventional arm, the gp will decide the need of telephone advice with or without drug prescription, home visit by a doctor, emergency department services with or without ems system. we will recall every patient at 15+/-4 days.

Eligibility criteria:
inclusion criteria: * disease: * fever: temperature ≥ 38 ° c * symptoms of gastroenteritis include nausea and / or vomiting and / or diarrhea * onset of symptoms for less than 72 hours * age ≥ 18 years caller * patient age ≥ 1 year * affiliation to the french national health service exclusion criteria: * pregnancy * severity criteria (fever\> 41 ° c, disturbance of consciousness, rash, dyspnea, signs of dehydration, chest pain, neurological signs, gastrointestinal bleeding) * seeking advice from institutional correspondents (fire brigade, police, airport...) * communication difficulties (non-communicating patient, language barrier...)

Keywords: triage hotline primary health care emergency medical service communication systems
effects of a probiotics on the health of normal young males

Conditions: Inflammation; Dyslipidemia

Summary: the important role played by the gi tract microflora on the metabolic health of an individual are increasingly recognized. in this respect, the initial studies of metchinkoff that suggested a role of fermented food (specifically yoghourts ) to modulate the gut microflora have evolved into the concept of "probiotics". probiotics are living microorganisms that bring a benefit to the host when administered in sufficient quantity (who/fao, 2001). here the investigators will study, in normal young male volunteers, the potential to modulate post-prandial metabolic and inflammatory responses by the administration of a yoghourt containing the probiotic lactobacillus rhamnosus (lgg).

this is a prospective, randomized, double-blind and cross-over study designed to evaluate the potential of a probiotic (lactobacillus rhamnosus) to modulate the post prandial metabolic and inflammatory response of normale healthy individuals. after a wash out period during which volunteers will have to follow a diet devoid of all milk or milk-derived products, they will receive, in random order, either a daily dose of the probiotic, or a daily dose of acidified milk (control) for a total of three consecutive weeks. at the end of each of these period, they will be submitted to a day of investigation, during which their metabolic and inflammatory profile will be studied following the ingestion of a standard test meal. the potential for the probiotic to modulate the metabolic and inflammatory parameters will be evaluated. the test meal will provide 1004kcal under the form of 45.4g proteins (17%), 69g total fatty acids (62%), and 52.6g glucids (21%) as previously published (schwander et al, j nut 2014).

Eligibility criteria:
inclusion criteria: * normal male with normal bmi (18.5-25 kg/m2) * non smoker * stable physical activity exclusion criteria: * food intolerance (ceoliac disease, lactose intolerance, food allergies) * particular regimen (vegetarian...) * chronic disease (any) * elevated blood pressure * regular drug treatment * antibiotics treatement in the preceding six months * \>4 hrs/week of physical activity

Keywords: probiotic yoghourt inflammation metabolomics
neurocognitive robot-assisted rehabilitation of hand function after stroke

Conditions: Stroke; Upper Extremity Paresis

Summary: the aim of this project is to clinically evaluate a novel robot-assisted therapeutic approach to train sensorimotor hand function after stroke. it combines the profound experience of the clinic hildebrand in neurocognitive therapy - involving brain and mind in the task and training both the motor and the sensory system - with the advanced haptic robotic technology of the rehabilitation engineering lab at the swiss federal institute of technology zurich (eth zurich), allowing unmet interaction with the hand through the simulation of virtual objects with various mechanical properties. in a randomized controlled clinical trial, 10 sub-acute stroke patients will receive four weeks of robotic therapy sessions, integrated seamlessly into their daily rehabilitation program, while 10 other patients will receive conventional therapy. the investigators will assess baseline performance in an initial clinical and robotic assessment, with another assessment at the end of the four-week period, and in follow-ups four weeks and six months later. the contents of the patient-tailored robotic therapy sessions will match those of the conventional therapy as closely as possible. this study will demonstrate the feasibility of including robotic therapy of hand function into the daily rehabilitation program, and investigate the acceptance from patients and therapists. the investigators expect increased training intensity during the robotic therapy session compared to conventional sessions with similar contents, as well as novel insights into the recovery process of both the motor and the sensory system during the four weeks of therapy, through advanced robotic assessments integrated into the training sessions. this project is a first step towards making such robotic therapy available to patients as integration into the conventional individual therapy program (e.g. for self-training), and towards transferring this technology to the home environment.


Eligibility criteria:
inclusion criteria: * age between 18-90 years old * hemisyndrome (central paralysis of the upper extremity, and all degrees of weakness: m0 - m5 on the paresis scale) as a result of a first stroke * sub-acute lesion not more than 6 weeks post ictus exclusion criteria: * insufficient state of consciousness * severe aphasia * severe cognitive deficits * severe pathologies of the upper extremity of traumatic or rheumatic nature * severe pain in the affected arm * patients with pacemakers and other active implants

Keywords: stroke acute rehabilitation robot therapy hand function fine motor skills neurocognitive sensory perfetti haptics
a feasibility study of multimodal exercise/nutrition/anti-inflammatory treatment for cachexia - the pre-menac study

Conditions: Cancer; Cachexia

Summary: a multicentre, open, randomized phase ii study comparing a multimodal intervention (oral nutritional supplements, celecoxib and physical exercise) for cachexia versus standard cancer care.


Eligibility criteria:
main eligibility criteria: * advanced non-small-cell lung cancer (stage iii-iv) or pancreatic cancer not eligible for curative therapy * due to commence chemo- or chemo radiotherapy * karnofsky performance score ≥ 70 * a life expectancy of ≥4 months and considered able to complete 2 months of the study

Keywords: cachexia neoplasms complications combined modality therapy exercise therapy diet therapy anti-inflammatory agents
the long-term course of moderate tricuspid regurgitation

Conditions: Tricuspid Regurgitation; Heart Failure; Echocardiography

Summary: to evaluate the long-term clinical outcome of a cohort of patients suffering from moderate tricuspid regurgitation (tr), regardless of its etiology.


Eligibility criteria:
inclusion criteria: 1. patients with an echocardiographic diagnosis of moderate tr 2. patients with echocardiographic and clinical follow-up information available at least 6-months after moderatetr diagnosis. exclusion criteria: 1. absence of an appropriate clinical and echocardiographic follow-up 2. a history of previous tv intervention (either surgical or percutaneous) 3. the presence of concomitant tv stenosis 4. congenital heart disease 5. left ventricular assist devices
prevalence, predictors and management of gastroesophageal reflux after laparoscopic sleeve gastrectomy

Conditions: Gastroesophageal Reflux

Summary: from january 2017 to january 2022, we looked at patients who had primary lsg and developed gerd. before and after surgery, patients for lsg performed barium meal in trendelenburg position and upper git endoscopy. esophageal manometry and 24 h ph metery for patients who developed gerd.

patients with morbid obesity who had lsg between january 2017 to january 2022were included in the trial, which was a multicenter cohort study. patients with morbid obesity, defined as a bmi of more than 40 or less than 35 with at least one comorbidity and ages ranging from 16 to 65, were patients' eligibility criteria for lsg. patients under the age of 16 or over 65, as well as those with severe gerd, pregnancy, or inflammatory bowel disease, were excluded from the trial. the data were recorded in a prospective manner in a computerized file, all patients signed the informed consent form after the description of the technique and possible postoperative morbidities. before and after surgery, patients for lsg performed barium meal in trendelenburg position and upper git endoscopy. esophageal manometry and 24 h ph metery for patients who developed gerd. the study's purpose was to determine the prevalence of gerd symptoms, as well as potential predictors of gerd symptoms following lsg and how gerd symptoms were managed after lsg.

Eligibility criteria:
inclusion criteria: * patients with morbid obesity defined as a bmi of more than 40 or * bmi less than 35 with at least one comorbidity and * ages ranging from 16 to 65, were patients' exclusion criteria: * patients under the age of 16 or over 65, * those with severe gerd, * pregnancy, or * inflammatory bowel disease,

Keywords: laparoscopic sleeve gastrectomy morbid obesity gerd
management of index episode in patients with bipolar disorder treated by seroquel xr

Conditions: Bipolar Disorder; New Occurred Episode

Summary: the primary purpose of the study is to explore management of symptomatology in patients with bipolar disorder that experience a new manic,depressive or mixed episode and are treated with seroquel xr monotherapy/adjuctive, in routine clinical practice in romania


Eligibility criteria:
inclusion criteria: * patients eligible for entry into the study, male and females, will have a diagnosis of bipolar disorder, as defined by dsm-iv-tr and the current episode, whether it is manic, depressed or mixed will be treated with seroquel xr since 1 week before entering the programme. * all eligible patients will be included in the programme provided they will receive information in advance and will sign consent to grant access to the data collected with regard to their condition during the observation interval proposed. exclusion criteria: * all the patients who have a known hypersensitivity to seroquel xr/quetiapine or any of its excipients will not be included in this study. * concomitant medication, that could result in drug interactions and could jeopardize patient safety will be carefully considered before having the patient enrolled. additionally, all precautions applicable for special category patients will be taken into account, as detailed in current valid romanian smpc.

Keywords: bipolar disorder new occured episode: manic depressive or mixed