Kornimate/medical-research-clean huggingface dataset:
effectiveness and safety of zingiber officinale transdermal patch for acne vulgaris; study of interleukin 1 and skin microbiome

Conditions: Acne Vulgaris

Summary: the goal of this clinical trial is to investigate the effectivity and safety of mild to moderate acne vulgaris therapy using zingiber officinale 5 % transdermal patch. researcher will compare both half faces (split face); one side as treatment side where patch is used, and another side as control. patient will be asked to apply tretinoin 0,025% cream nightly. after applying tretinoin 0,025% on whole face, patient will be asked to apply patch on a pustule on one half face, and no patch will be used on another half face. total lesion count will be assessed before treatment and 21 days after treatment. specimen for skin microbiome and interleukin examination will be collected before and 21 days after treatment.

current acne vulgaris treatment include antibiotic, retinoic acid, and benzoyl peroxide. the use of antibiotic has been linked to antibiotic resistant problem. research also has shown the association between acne vulgaris and skin microbiome. therefore, new treatment for acne vulgaris that has good effect on skin microbiome is needed. z. officinale is an herb that commonly used in traditional medicine. researches have shown that it has anti-inflammation activity and antibiotic activity to cutibacterium acnes. on the other hand, the prebiotic potency of z. officinale on gut microbiome has also been investigated. this randomized controlled trial shall include 26 mild to moderate acne vulgaris patients according to inclusion and exclusion criteria. patches will be given every 5 days as researcher follow up patient condition. patient photograph will be taken before treatment, on follow up day, and after 21 days treatment. skin microbiome specimen will be collected using skin swab method. secret from a chosen pustule will be collected for interleukin examination. during clinical trial, patient will use non comedogenic sunscreen and soap from researcher. patient will be asked to report to researcher if there is side effect of treatment.

Eligibility criteria:
inclusion criteria: * female * 15-45 years old * mild to moderate acne vulgaris according to lehmann criteria * minimal 3 pustules on face that are distributed on right and left sides exclusion criteria: * history of allergy to ingredients that is used in research * history of topical acne medication and steroid in the last 2 weeks * history of medical aesthetic procedure such as laser and chemical peeling in the last 2 weeks * history of oral antibiotic therapy in the last 6 weeks * history of oral isotretinoin therapy in the last 6 months * history of probiotic consumption in the last 3 weeks * pregnancy and lactation

Keywords: acne vulgaris, zingiber officinale, microbiome
high dose donor hematopoietic stem cell infusion for relapsed/refractory aml

Conditions: Leukemia, Myeloid

Summary: the purpose of this study is to evaluate the safety and efficiency of high dose allogeneic mismatched hematopoietic stem cells infusions after normal chemotherapy in patients with relapsed/refractory acute myeloid leukemia（aml）.

the relapsed/refractory aml patients will receive ia/da/ma(i,idamycin，d，daunorubicin，m，mitoxantrone，a，cytosine arabinoside) chemotherapy followed by infusion of high dose allogeneic mismatched hematopoietic stem cells. no graft-versus-host disease (gvhd) prevention will be conducted before transplantation. cytokine storm,gvhd snd donor graft will be detected post-transplantation.

Eligibility criteria:
inclusion criteria: * patient with relapsed and/or refractory aml * estimated life expectancy ≥ 12 weeks (according to investigator's judgment) * eastern cooperative oncology group (ecog) performance status ≤ 2 exclusion criteria: * previous treatment with investigational gene or cell therapy medicine products * any uncontrolled active medical disorder that would preclude participation as outlined

Keywords: acute myeloid leukemia relapsed refractory hematopoietic stem cell
gut- and vaginal microbiome composition in association with pcos

Conditions: Polycystic Ovary Syndrome

Summary: polycystic ovary syndrome (pcos) is an endocrine disorder that affects up to 10% of the reproductive-aged women worldwide. the etiology is still unknown and treatment therefore remains symptomatic. studies indicate a possible role of the gut microbiome in the pathology of pcos. pcos women have a disturbed gut microbiome, with certain species associated with the pcos characteristics:hyperandrogenism, ovarian dysfunction, obesity, glucose intolerance and insulin resistance. although differences have been found in gut microbiome composition between pcos and healthy women, the literature is inconclusive regarding the difference in gut microbiome biodiversity. studies examining the vaginal microbiome in pcos women show consistent results with specific species in the vaginal microbiome. however, there are only few studies on the vaginal microbiome in pcos women and no studies have yet investigated the correlation between sex-specific hormones and pcos characteristics. more research is needed to understand the function of the microbiome in the pathophysiology of pcos, so that this can offer perspectives in future therapies.


Eligibility criteria:
inclusion criteria * caucasian * willing to provide vaginal swab and stool sample * willing to provide informed consent * sufficient command of the dutch language * diagnosed with pcos at erasmus mc using the rotterdam criteria by the presence of at least two of the following criteria * clinical or biochemical hyperandrogenism (modified ferriman-gallway score \>5; testosterone level \>2nmol/l, free androgen index \> 2.9) * oligomenorrorrhea or amenorrhea * polycystic ovaries. exclusion criteria * bmi \<18 * smoking * diabetes mellitus or use of insulin sensitizer * chronic and acute infection diseases * endometriosis (american fertility score (afs) iii/iv) * elevated prolactin levels, thyroid disease, cushing disease or gastro-intestinal disease * the use of hormonal contraceptives, and other steroid hormones in the last 3 months * use of antibiotics, probiotics or laxatives in the last 3 months

Keywords: gut microbiome vaginal microbiome polycystic ovary syndrome
special drug use investigation for allermist (long term)

Conditions: Rhinitis

Summary: this post-marketing surveillance study is to investigate possible problems or questions in safety and efficacy of allermist nasal spray for long-term use in japanese subjects with allergic rhinitis under the conditions of actual practical use.


Eligibility criteria:
inclusion criteria: * diagnosis of allergic rhinitis * use allermist for the first time * expected to use allermist for long-term (1 year). exclusion criteria: * subjects with infection which fluticasone is not effective * subjects with deep mycosis * subjects with hypersensitivity to fluticasone
total occlusive ionic silver-containing dressing vs mupirocin ointment application vs conventional dressing in elective colorectal surgery: effect on incisional surgical site infection

Conditions: Incisional Surgical Site Infections

Summary: the patients were randomized into 3 groups: those patients undergoing a ionic silver-containing dressing (isd) (group 1), those undergoing a mupirocin ointment application (moa) (group 2) and those using a conventional dressing (group 3) in the surgical wound after finishing an elective colorectal surgery.


Eligibility criteria:
inclusion criteria: * diagnosis of colorectal neoplasms and plans to undergo an elective surgery with curative aims. * open surgical approach exclusion criteria: * anastomotic leak * mortality * lost to follow-up
muscle evaluation using ultrasound in the critically ill

Conditions: Critical Illness; ICU Acquired Weakness

Summary: critical illness is associated with icu acquired weakness and diaphragmatic dysfunction. ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the icu stay. magnetic stimulation of the phrenic nerves and the measure of the end expiratory tracheal pressure with an occlusion valve allows to evaluate the diaphragm force production in mechanically ventilated patients. the aim of the present study is to constitute an image bank and to describe the muscle mass and function recovery in critically ill patients.

critical illness is associated with icu acquired weakness and diaphragmatic dysfunction. ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the icu stay. magnetic stimulation of the phrenic nerves and the measure of the end expiratory tracheal pressure with an occlusion valve allows to evaluate the diaphragm force production in mechanically ventilated patients. the aim of the present study is to constitute an image bank and to describe the mass and function recovery in critically ill patients. ultrasound and clinical data will be collected and analysed during the icu stay.

Eligibility criteria:
inclusion criteria: * critically ill patients with at least one organ failure defined, organ failure being defined by a sofa equal or above 3 for the organ, and an expected duration of icu stay equal of above 3 days exclusion criteria: - pregnancy, age below 18, absence of consent

Keywords: diaphragmatic dysfunction mechanical ventilation icu acquired weakness weaning skeletal muscles respiratory muscles
telomere length and other parameters of telomere dysfunction in psc and colitis

Conditions: Primary Sclerosing Cholangitis; Inflammatory Bowel Disease

Summary: psc is a chronic cholestatic disorder. the investigators intend to study some telomere parameters and telomere length in order to predict a premalignant state.

primary sclerosing cholangitis (psc) and colitis are chronic inflammatory disorders with malignant potential. telomerase is an enzyme complex that lengthens telomeres and has enhanced expression in numerous malignancies. in this study, we evaluated the telomerase gene copy number, telomere length, cells in senescence, aneuploidy and additional parameters of telomere dysfunction from peripheral blood lymphocytes of patients.

Eligibility criteria:
inclusion criteria: * informed consent * documented psc and inflammatory bowel disease exclusion criteria: * under 18 years, above 80 y * known active malignancy * decompensated cirrhosis * patients who cannot sign informed consent

Keywords: telomeres psc
healthy eating, activity, & lifestyle training headquarters: ii pilot project

Conditions: Overweight; Weight Loss

Summary: the proposed study aims to combine evidenced based tools and guidance (h.e.a.l.t.h.: healthy eating activity lifestyle training headquarters) previously tested that has been developed specifically for use by army soldiers and a remote clinical intervention model that includes mobile tracking technology/devices for physical activity, weight and nutrition. this program is called the h.e.a.l.t.h. intensive.

the purpose of this investigation is to test the efficacy of a remote intervention to assist soldiers in meeting standards for body fat and fitness. the intervention will include: 1. an internet/smartphone program for weight management and weight gain prevention developed during previous dod research. 2. integrated remote monitoring technology/devices, e.g. smart scales, activity tracking devices. 3. individualized weight management and exercise recommendations based on data collected from web/mobile app/devices to be delivered via web/mobile app/smartphone; participants will not travel to a clinical facility for the intervention. the objectives are: 1. to further develop the h.e.a.l.t.h. intervention by merging components of the h.e.a.l.t.h. program, remote monitoring technology components, e.g. activity tracking devices, smart scales, and direct/individualized weight management and exercise feedback into a single and comprehensive intervention that targets weight and fat loss, improved fitness, improved sleep, and personal well-being for soldiers and their family members. 2. compare body weight, body fat, and activity changes associated with participation in the h.e.a.l.t.h intensive intervention for six months and a six-month website only phase/follow-up phase, in comparison to participation in a wait-list control group; and 3. evaluate blood biomarkers associated with changes in body weight. evaluate changes in gut bacteria associated with body weight.

Eligibility criteria:
inclusion criteria: 1. male and female soldiers who are members of the louisiana national guard * direct family member of the lang member who is enrolled in the study and will participate with the soldier 2. ≥18 years old 3. for soldiers: bmi ≥ 25, and who exceeds screening table weight and maximum allowed body fat as outlined by ar600-9 army regulations for family member: bmi ≥ 25 4. has no known deployments (to the best of their knowledge) for one year upon beginning the study exclusion criteria: 1. soldiers and family members younger than 18 years of age 2. soldiers and family members who are pregnant 3. soldiers and family members who cannot read 4. soldiers and family members who do not have daily access to wifi 5. soldiers and family members who do not have access to a smartphone

Keywords: physical activity sleep nutrition soldier prevention remote monitoring mobile technology
melanoma detection in switzerland with vectra

Conditions: Melanoma (Skin)

Summary: this study is to compare 2d- and 3d-imaging and routine clinical care in early melanoma detection in a prospective large-scale real-world data set.

this study is to compare the accuracy of combining human and artificial intelligence with its independent application in early melanoma detection. the artificial intelligence (ai)-powered 3d total body photography (tbp) vectra® wb360 system's utility and clinical performance in detecting melanoma in the real-world setting will be compared to the gold standard with clinical assessments by experienced dermatologists, to currently widespread used 2d imaging tools (fotofinder atbm® master) and to the smartphone-based algorithm application (e.g. skinvision®). here included are specific questions regarding the patients' subjective experience, acceptance and evaluation of modern technological examination. additionally, the overall psychological burden and worry of melanoma risk or disease, anxiety, depression will be compared in different groups of patients and psychological support need and real uptake of support and its predictors will be investigated in all participants. to validate the melvec (melanoma detection in switzerland with vectra®) test procedure, an analysis of the measurement repeatability of computer-guided risk assessment scores for early melanoma detection will be performed. a potential benefit of this validation analysis is the optimization of study procedure for future follow-up visits and further enrolled patients in the melvec study. additionally, results will shed light on the reliability of the convolutional neural networks (cnns) investigated and help formulate recommendations for their current use. furthermore, results will provide important data for the manufacturers regarding the systems' reliability in clinical application to help future improvement of the respective algorithms.

Eligibility criteria:
inclusion criteria: * written informed consent of the patient * sufficient fluency in german language skills to complete all questionnaires of the study without external assistance * high-risk criteria for melanoma. for "high risk" one of the following criteria needs to be fulfilled: * at least one previous melanoma (including melanoma in situ) * a diagnosis of ≥ 100 nevi * a diagnosis of ≥ 5 atypical nevi * a diagnosis of dysplastic nevus syndrome or known cdkn2a mutation * a strong family history (≥ 1 first- and/or second-degree relatives) exclusion criteria: * lack of informed consent for study participation. * fitzpatrick skin type v-vi. * acute psychiatric illness or acute crisis

Keywords: 3d total body photography (tbp) 2d sequential digital dermatoscopic imaging (sddi) skin malignancy artificial intelligence (ai)- based tools 3d tbp vectra® wb360 system fotofinder atbm® master skinvision®
comparison of a chemically activated composite resin alkasite with resin composite in atypical caries lesions of deciduous teeth

Conditions: Dental Caries in Children

Summary: atypical cavities, which involve more than two surfaces, one being buccal or lingual/palatal, are a challenge for restorative dentistry, since the risk of restorative failure is related to the number of surfaces involved. thus, the purpose of this umbrella project is to conduct a randomized controlled trial (rct) to evaluate the efficacy and patient-centered outcomes of a chemically activated composite alkasite resin in atypical deciduous molar lesions. primary molars of children aged 4 to 7 years with at least one atypical cavitary lesion in primary molars will be selected for the rct. the selected teeth will be randomly divided into: alkasite chemically activated composite resin and bulk fill composite resin. clinical and radiographic follow-up of the lesions will be performed for 6 and 12 months. the effectiveness of the treatments will be evaluated by the longevity of the restorative procedures and paralysis of the lesions. patient-centered outcomes will also be evaluated.


Eligibility criteria:
inclusion criteria: * children will be included who have at least one posterior tooth with atypical caries lesion. exclusion criteria: * patients with special needs will be excluded, with general health conditions that may affect the oral cavity, non-cooperating in relation to the examination, which use orthodontic apparatus and the parents/guardians or children not to consent to their participation in the study. in addition, teeth with pulp exposure, spontaneous pain, mobility, presence of swelling or fistula close to the tooth, furcation or cervical injury, teeth with restorations, sealants or enamel formation defects will be excluded.

Keywords: dental caries deciduous teeth permanent dental restoration
scoring-balloon angioplasty and sirolimus-eluting balloon angioplasty for the treatment of diffuse, small vessel coronary artery disease (sca-deb study)

Conditions: Coronary Artery Disease

Summary: this is a prospective, single-center, single-arm study to evaluate the feasibility and safety of the combination of scoring-balloon angioplasty and sirolimus-eluting balloon angioplasty for the treatment of diffuse, small vessel coronary artery disease. the objective of the study is to demonstrate the feasibility and safety of the combination of scoring-balloon angioplasty (sba) plus sirolimus-eluting balloon angioplasty (seba) for diffuse (lesion length ≥20 mm), small vessel (diameter 1.5 mm -2.75 mm) coronary disease.


Eligibility criteria:
inclusion criteria: 1. patientsaged≥18years. 2. presence of epicardial coronary artery disease with lesion length ≥ 20 mm and vessel diameter less than 2.75 mm and more than 1.5 mm with diameter stenosis \>50% by visual evaluation. exclusion criteria: 1. life expectancy \< 2 years 2. left ventricular ef ≤40% 3. pregnantorlactatingfemales. 4. moderate and moderate-to-severe valvular heart disease. 5. hemodynamic instability. 6. severe renal dysfunction, defined as an egfr \<30 ml/min/1.73 m2 7. patients with hypersensitivity or allergies to aspirin, heparin, clopidogrel, ticlopidine, bivalirudin, prasugrel, ticagrelor and drug such as sirolimus (rapamycin) or similar drugs or any analogue or derivative, hydrogenated castor oil, pvp or any contrast media. 8. patients in whom anti-platelet and/or anti-coagulant therapy are contraindicated. 9. patients judged to have a lesion that prevents complete inflation of an angioplasty balloon. 10. transplant patients. 11. patients with calcified lesion requiring other type of treatment such as rotational atherectomy. 12. unprotected left main coronary artery lesions 13. coronary artery spasm in the absence of a significant stenosis. 14. patients whose diseased segment cannot be pre-dilated or prepared before drug coated balloon treatment.
hcc screening using dna methylation changes in ctdna

Conditions: Hepatocellular Carcinoma

Summary: hepatocellular carcinoma (hcc) is the fifth most common cancer world-wide. it is particularly prevalent in asia, and its occurrence is highest in areas where hepatitis b is prevalent, indicating a possible causal relationship. follow up of high-risk populations such as chronic hepatitis patients and early diagnosis of transitions from chronic hepatitis to hcc would improve cure rates. in most cases hcc is detected late resulting in increased mortality and morbidity. the purpose of this study is to develop and test non-invasive biomarkers based on methylation changes in pbmc and circulated tumor dna in hepatocellular carcinomas patients.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of hcc by easl-eortc guidelines * confirmed hepatitis b diagnosis for hepb patients using aasld practice guidelines. exclusion criteria for hcc: * cirrhosis, any other known inflammatory disease (bacterial or viral infection with the exception of hepatitis b or c, diabetes, asthma, autoimmune disease, active thyroid disease) which could alter t cells and monocytes characteristics * other cancers. exclusion criteria for hepb: * diagnosis of hcc or any other cancer. exclusion criteria for healthy controls: * any known inflammatory or infectious disease including hepb and hepc * chronic diseases, * cancer * medications or drug use
rabies treatment by exposure of patient to x-ray

Conditions: Treatment of Rabies

Summary: x-ray has been proven to kill rabies virus in vitro, so the investigators can use it in treatment of rabies infected patients.

x-ray has been proven to kill rabies virus in vitro, so the investigators can use it in treatment of rabies infected patients. this can be done by exposure of infected , manifested patient who didn't receive prophylaxis or delayed in receiving immunoglobulins . also can be applied to patients who have the injury in upper body near the cns.. it's just an idea and the investigators need help to approve its effect and the investigators believe it will really work and give a new, rapid , cheap and very effective treatment to a 100% fatal disease.. the investigator also predict good results when x ray applied to some localized infections beside its current lines of treatment..

Eligibility criteria:
inclusion criteria: * patient bitten by rabid animal with signs and symptoms exclusion criteria: * bitten by non rabid animal
transvaginal treatment of symptomatic cystocele grade ii-iii

Conditions: Cystocele

Summary: this observational study will evaluate treatment of symptomatic cystocele grade ii-iii with cousin biomesh and allium medical endofast reliant. data about 100 patients will be collected. follow-up till 3 years after the procedure. primary endpoint is absence of recurrence.


Eligibility criteria:
inclusion criteria: * patient is a woman * patient is between 40 and 90 years old * patient has to sign the informed consent form prior to the procedure * patient has to agree with the scheduled follow-up visits on month 1, month 6, year 1, year 2 and year 3 * patient has symptomatic anterior prolapse exclusion criteria: * recurrence cystocele * patient is pregnant * patient has a wish to become pregnant * patient is taking plavix, sintrom, marcoumar, marevan, brilique, efient, ticlid, xarelto, eliquis or pradaxa. if intake is stopped prior to procedure, patient is allowed to be included. * patient is taking lmwh in a dose of more than 40 mg/day * patient has a life expectancy \< 1 year * patient has a known connective tissue disease * patient has a history of surgery of the anterior vaginal wall or pelvis * a scheduled hysterectomy during the index-procedure

Keywords: anterior prolapse