Kornimate/medical-research-clean huggingface dataset:
utility of analyzing atrial signal electrograms in patients with atrial fibrillation using next-generation ensite x software: a prospective study

Conditions: Atrial Fibrillation (AF)

Summary: a single-center clinical trial on the analysis of intracardiac atrial electrogram mapping before and after ablation with the hd grid mapping catheter and ensite x software, as a prospective study.

this study was designed to determine the efficacy of substrate ablation using hd grid mapping catheter could collected more af electrogram and facilitate the mapping resolution and driver identification in af patients who required substrate modification. this study is a prospective, single-center in which patients with af who will receive catheter ablation. the priority of substrate modification would be determined by the mapping with the hd grid mapping catheter. the end-point of ablation is non-inducible of af or afl. the procedure time, fluoroscopic time, procedural termination rate, and recurrence of atrial arrhythmia would be collected. if the flutter or the non-pv triggers were inducible, isthmus ablation and the non-pv trigger ablation will be performed accordingly.

Eligibility criteria:
inclusion criteria: 1. patents who sign the informed consent forms, and allow to be followed. 2. symptomatic af refractory or intolerant to at least one class 1 or 3 antiarrhythmic medication. 3. patients with age equal or greater than 20 years old regardless of gender. exclusion criteria: 1. the presence of a atrial or ventricular thrombus. 2. patients who are allergic to or unsuitable for use with the contrast media. 3. pregnant patients or patients who are unavailable to receive x-ray. 4. patients with renal insufficiency. 5. patients had autonomic nervous system disorder (e.g. respiratory apnea) 6. patients with age less than 20 years old or greater than 80 years old regardless of gender.

Keywords: atrial fibrillation ensite x software atrial arrhythmia catheter ablation
diagnostic performance of the s100b protein in the prognosis of patients with mild head trauma with risk of complications in patients over 65 years old.

Conditions: Mild Head Trauma With Risk of Complications

Summary: for patients with mild head trauma, a large number of ct scans are performed. the s100b protein allows, when the dosage is below the threshold, to rule out the diagnosis of brain damage with a negative predictive value of 98%. in patients over 65 years old it was found that the dosage of s100b came back positive more often compared to a younger population. this study proposes to determine the positivity threshold value for s100b dosage in patients over 65 years old. in patients over 65 years suffering from mild head trauma, a head ct will systematically be performed (in accordance with the recommendations) and the s100b will be measured (taken from an additional tube on the blood test carried out in these patients). the results of the tdm will then be compared with the results of the s100b to determine the values of sensitivity, specificity, negative and positive predictive value of different thresholds.


Eligibility criteria:
inclusion criteria: * male or female aged 65 or more * patients going to the emergency for a mild head trauma with risk of complication and treated within 3 hours of the head injury, according to the following criteria: * adult patients with head trauma presenting: * retrograde amnesia lasting more than 30 min, or * a loss of consciousness or amnesia of the facts or * glasgow score \<15 to 2 hours from traumatism * speaking and reading french * subject having expressed his non-opposition to the research or non-opposition given by a trusted person / member of his family in cases where the patient is not in a position to express his non-opposition. * subject affiliated to a social health insurance protection scheme exclusion criteria: * severe head trauma * mild head trauma without risk of complication * patient under the protection of justice * patient under guardianship, curatorship * subject in exclusion period (determined by a previous or current study)
the assessment of volume status by bia and lung ultrasound in septic aki patients undergoing crrt

Conditions: Septic Acute Kidney Injury

Summary: acute kidney injury(aki) is one of the most common complications that occur up to 35% of critically ill patients. septic aki accounts for one third of them. patients with septic aki are widely treated with continuous renal replacement therapy (crrt). however, previous studies have hardly documented improvement of mortality in septic aki patients. otherwise, fluid overload in septic shock patients who are undergoing crrt is proven to be a significant predictor for mortality. recent studies showed efficacy of bioelectrical impedance analysis and lung ultrasound in assessing fluid status of the patients. thus, hypothesis of the study is that fluid assessment and control of fluid status using bia and lung ultrasound could be related to the outcome of septic aki patients who undergo crrt. in this study, the investigators measure the fluid status of the patients by bioelectrical impedance analysis and lung ultrasound for experimental group, while for control group, fluid status would be determined clinically by the physician. ultrafiltration rate of experimental group is adjusted to be equal to the value of overhydration measured by bia.


Eligibility criteria:
inclusion criteria: 1. body temperature \ 38 °c 2. heart rate \> 90 bpm 3. respiratory rate \> 20 or apaco2 \< 32 mmhg on abg 4. white blood cell count \ 12,000 cells/mm3 or band forms (immature white blood cells) ≥10% 5. evidence of infection 6. wbcs in normally sterile fluid 7. perforated viscus 8. radiologically proven infection 9. more than injury stage in aki according to rifle criteria 10. septic aki which is not explained by other cause 11. patients signed a written informed consent. exclusion criteria: 1. younger than 19 years old, older than 80 years old 2. previously undergoing dialysis treatment due to esrd 3. underlying malignancy, life expectancy shorter than 3 month 4. aki due to other than sepsis 5. patients with intracardiac device such as pacemaker, crt, icd

Keywords: septic aki crrt bia
observational study for perioperative care of patients requiring icu (opicu)

Conditions: Indication, Unlabeled; Complication,Postoperative

Summary: this clinical trial will be carried out as a national multicenter observational cohort trial in turkey. our starting point is the need to triage postoperative patients daily due to the limited intensive care unit (icu) bed capacity. our hypothesis is that patients requiring emergency or unplanned icu admission generally meet the icu admission criteria. however, postoperative patients admitted to the icu for planned reasons often do not meet the icu admission criteria and can be monitored in a lower-level unit (postoperative care unit - pacu) for close observation purposes. the primary aim is to assess the efficient utilization of icu beds. we try to compare the treatments provided during icu follow-up, for planned and unplanned patients requiring icu admission. our secondary outcome is to identify criteria that can predict icu indications based on patients' preoperative characteristics and evaluate the postoperative complications according to the clavien-dindo classification. our aim is to categorize patients admitted to the icu into two groups: planned and unplanned/emergency cases and compare the necessity of icu care between these two groups. the need for icu treatment will be determined based on the criteria established in the following\* study. the presence of any of these criteria will indicate the need for icu admission, while the absence of these criteria may identify patients admitted to the icu only for monitoring purposes (i.e., unnecessary icu admissions).

surgical cases involving patients over 18 years of age requiring postoperative intensive care will be included (including patients who were admitted urgently, or patients that is planned but not admitted to icu after the surgery). cardiac surgery cases, outpatient cases, pediatric surgery cases, patients undergoing surgery while hospitalized in the icu, patients undergoing only interventional procedures, and those who do not provide consent will be excluded from the study.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * major elective/emergency surgical procedures * planned, unplanned, emergent surgical procedures, planned but not admitted to the icu after the operation. * patients who planned but not transferred to the icu will also be followed/ included postoperatively * informed consent * major surgeries will be targeted within the broad subgroup domains of gynecology, neurosurgery, thoracic, urology, orthopedics/trauma, and abdominal surgery. * unplanned but admitted to icu after surgery in 48 hrs. exclusion criteria: * day-case surgery * cardiac surgery * pediatric surgery * patients who were already staying in icu and planned to be operated on * denial of informed consent * all interventional procedures

Keywords: intensive care triage postoperative period
the effect of pilates and myofascial release on flexibility

Conditions: Health, Subjective

Summary: the aim of this study is to compare the short and long term effects of pilates and myofascial relaxation technique on flexibility, muscle strength, dynamic balance, neural tension and pain threshold. to evaluate the effects of myofascial release technique on neural tension. to evaluate the effects of pilates on neural tension. to evaluate the effects of the protocol applied in combination with pilates and myofascial release technique in healthy women.

pilates is a synthesis of balance, breathing and movement systems that predict the unity of mind and body developed by joseph pilates. breathing correctly and adequately allows more oxygen to go to all the tissues in our body. pilates; it includes 6 key principles: breath, concentration, control, precision / accuracy, centering, rhythm / fluency. it activates every muscle in the body, gives balance and flexibility, and shapes the posture by improving the body. by correcting the posture, it protects the musculoskeletal system problems caused by the posture disorder and helps the body to be more flexible and increase the strength and endurance of the muscles. it provides control over all joint movements, especially the spine. it improves balance and coordination. fascia is a single, inseparable connective tissue that wraps, supports, protects, connects all tissues. it is a dynamic structure with many sensory receptors, constantly changing and adaptable, it is the largest system in the human body. myofascial release technique can be defined as low-intensity, long-term mechanical force applied to the myofascial complex in order to dissolve fascial adhesions, reduce pain, ensure optimal length of the muscle, and increase functionality. it has been shown that myofascial release applied to the hamstrings in healthy individuals provides an increase in the normal range of motion of the hip. the effects of pilates and myofascial release technique on flexibility, muscle strength, dynamic balance, neural tension and pain threshold will be evaluated.

Eligibility criteria:
inclusion criteria: * be between the ages of 18-50 * be woman having a score of 600 or more when the international physical activity questionnaire (short) was administered * not be in menopause * not having had lower extremity surgery * no traumatic injury in the last 1 year exclusion criteria: * women entering menopause * international physical activity questionnaire (short) score less than 600 * those who have had lower extremity surgery * those with traumatic injury in the last 1 year

Keywords: pilates myofascial release flexibility muscle strength
effects of topical hyaluronic acid gel on postoperative pain and wound healing

Conditions: Palatal Wound

Summary: this clinical study aims to investigate the impact of a topical hyaluronic acid (ha) gel on postoperative pain and wound healing at palatal donor sites in patients undergoing mucogingival procedures involving a de-epithelialized gingival graft (dgg) from the palate. the study design is a phase iii, randomized, double-blind, parallel-group, clinical trial, conducted in a single center, with 30 subjects aged 18-70 years.


Eligibility criteria:
inclusion criteria: * males and females, between 18-70 years of age * informed consent form signed and availability for the duration of the study * good general health (absence of any condition that, in the opinion of the principal investigator, might constitute a risk to the subject while participating in the study * clinical indication for mucogingival surgery that requires a de-epithelialized gingival graft (dgg) from the palate * willingness to provide information related to their medical history * minimum of 10 uncrowned permanent natural teeth (excluding third molars) * normal salivary flow exclusion criteria: * oral pathology, chronic disease, or a history of allergy to testing products * subject using anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory medication or daily analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study * subject participating in any other clinical study * subject pregnant or breastfeeding * subject allergic to oral care products, personal care consumer products, or their ingredients * extended use of antibiotics or therapeutic mouthwash any time during the three months prior to entry into the study * a medical history reporting that the subject has a current systemic or autoimmune disease, such as diabetes, lupus, etc * ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine)

Keywords: topical hyaluronic acid postoperative pain wound healing epithelialized palate supportive care treatment prevention
weight loss maintenance (wlm)

Conditions: Cardiovascular Diseases; Heart Diseases; Obesity; Diabetes Mellitus, Non-insulin Dependent; Hypertension

Summary: to determine the effectiveness of continuous patient contact on weight loss maintenance.

background: overweight/obesity is the second leading cause of death in the us, and is growing in prevalence at an alarming rate. control of overweight/obesity is increasingly recognized as a high national priority because of its contribution to cardiovascular (cvd) risk factors and ultimately to cvd itself. the short-term success of behavioral interventions for weight loss has been repeatedly documented. unfortunately, because weight re-gain is extremely common, a disappointingly, small proportion of individuals achieve long-term weight control. of the factors that are associated with sustained weight loss, one of the most important is continued intervention with frequent contacts. design narrative: the study is a multi-center, randomized, controlled trial \[weight loss maintenance trial (maintenance)\] to determine the effects of two innovative behavioral interventions, each designed to maintain frequent contacts, compared to a usual care control group. overweight and obese individuals (60% women, 40% african americans) who are taking medication for hypertension, dyslipidemia and/or type 2 diabetes will enter a 6-month, weight loss program. those 800 individuals who lose at least 4 kg (approximately 9 pounds) will then be randomized into one of three groups: a personal contact (pc) intervention that provides monthly personal contacts with a trained interventionist, primarily via telephone; an interactive technology (it) intervention that provides frequent contacts through a state-of-the-art interactive web-based program supplemented by other communication technologies; or usual care (uc). the primary outcome will be weight change from the end of the initial weight loss program to the end of the 30-month weight maintenance intervention period. other outcomes will include weight change in subgroups, prevalence of cvd risk factors, measures of behavior change, and cost of implementation. for each outcome, the personal contact and interactive technology interventions will be compared to usual care and, if different from usual care, to each other. to successfully combat the obesity epidemic, clinicians and health care systems must have options that are effective and feasible and that can be provided to large numbers of individuals. phase ii intervention completed: july 2007 phase iii intervention completed: october 2009

Eligibility criteria:
overweight men and women who took medication for hypertension, type 2 diabetes and/or hyperlipidemia in the six month weight loss phase. and who were able to lose approximately 9 pounds. there will be approximately 60% women and 40% african americans.
serum zinc, peptic ulcer disease and h. pylori infection

Conditions: Peptic Ulcer Disease

Summary: fifty consecutive patients with symptoms suggestive of peptic ulcer disease were included. all underwent complete clinical evaluation, laboratory investigations, upper gastrointestinal endoscopy and rapid urease test. measurement of serum zinc level was done for all the included patients in addition to twenty five age and sex matched healthy control subjects.


Eligibility criteria:
inclusion criteria: * symptoms suggestive of peptic ulcer disease like epigastric pain, dyspepsia, heartburn exclusion criteria: * patients who received zinc supplementation, proton pump inhibitors (ppi), non-steroidal anti-inflammatory drugs (nsaids) * those presented with hematemesis or melena * those with chronic liver disease, renal failure, malabsorption or previous gastric surgery
post operative pain assessment after pulpectomy of primary molars with two different rotary systems

Conditions: Pulp Necroses

Summary: evaluation of post operative pain after pulpectomy procedures for primary molars with irreversible pulp damage and without periapical radulicency using two different systems (one shape file ( ratation movemont) and wave one gold file ( reciprocation movement)


Eligibility criteria:
inclusion criteria: * age of more than 4 years * healthy children * primary molars with irreversible pulp damage exclusion criteria: * presence of periapical radiolucency realtes to primary molar * uncooperative child
study of gulf war illness (gwi) by comparing gwi and healthy veterans

Conditions: Gulf War Illness; Persian Gulf War Syndrome

Summary: determine if: * genetic differences of cndp1 gene * the previously defined gwi/chronic fatigue syndrome (gwi/cfs) cerebrospinal fluid proteome contents * psychometric * other variables can differentiate between veterans of the 1990-1991 persian gulf war who have autonomic, neurological and other symptoms and those without these complaints.


Eligibility criteria:
inclusion criteria: * evidence of military enlistment between august 1, 1990 and july 31, 1991, and deployment for 30 consecutive days to: * persian gulf waters and adjacent land areas * other global locations * u.s. only * status prior to 1990 and 1991: * active duty * national guard * reserves exclusion criteria: * current active duty military personnel * any one who was not active duty military personnel between august 1, 1990 and july 31, 1991 * hiv/aids; pregnancy or lactation; potential hepatitis; drug addiction; chronic inflammatory, infectious, or autoimmune medical illnesses not associated with gwi; incarceration; dementia, other cognitive limitation; or reliance on a care-giver in order to respond to the questionnaires and other study tests. amputations of one or both hands and forearms will be permitted but hand grip tests will not be tested

Keywords: cndp1 carnosine dipeptidase 1 persian gulf war gulf war syndrome gwi gulf war illness exercise chronic fatigue fibromyalgia veterans irritable bowel syndrome migraine headaches neuropathy multiple chemical sensitivity
improving learning in hispanics with tbi or ms

Conditions: TBI (Traumatic Brain Injury) or MS (Multiple Sclerosis)

Summary: the goal of this study is to establish that a memory retraining protocol, originally developed for english-speakers, and translated into spanish, is effective.

a pilot study will be conducted to carry out this validation and resolve any methodological concerns in the translated protocol. 20 spanish-speaking hispanics at least one year post-traumatic brain injury (tbi) and 20 spanish-speaking hispanics with multiple sclerosis (ms), both with an objective deficit in learning and memory will be recruited. baseline assessment includes neuropsychological evaluation using traditional measures as well as completion of a number of questionnaires designed to measure everyday memory and everyday functioning. subjects are randomly assigned to either the experimental or control groups. experimental and control treatments includes two 45-60 minute sessions, twice per week, for 5 weeks. follow-up assessment includes a neuropsychological evaluation using traditional measures as well as completion of a number of questionnaires designed to measure everyday memory and everyday functioning. protocol efficacy will be determined by improvements between baseline and follow-up on an objective measure of learning and memory.

Eligibility criteria:
inclusion criteria: * between the ages of 18 and 65 * spanish is my dominant language, and i have had a traumatic brain injury or i have multiple sclerosis. exclusion criteria: * participants with major depressive disorder, schizophrenia, bipolar disorder i or ii * ms subjects: individuals with a history of head injury, stroke, seizures, or any other significant neurological history will not be included in the study. * tbi subjects: individuals must have sustained a tbi at least one year prior to enrollment in the study protocol. individuals with a history of significant neurological insult other than tbi (e.g. premorbid epilepsy, multiple sclerosis, alzheimer's disease) will not be included in the study.

Keywords: cognitive rehabilitation memory
use of ocular point of care ultrasound in diagnosing retinal detachment in the emergency department

Conditions: Retinal Detachment

Summary: the study is collecting data along with other academic institutions regarding the accuracy of ocular ultrasound in diagnosing retinal detachment.

this is a prospective, cross-sectional study to assess the utility of point of care ultrasound in the diagnosis of ocular complaints in the emergency department (ed) with specific focus on the accuracy of diagnosis when compared to that of a blinded ophthalmologist. ocular complaints represent between 2% and 3% of ed visits (walker et al, 2011). this percentage may include vision-threatening diagnoses including retinal detachment, which can occur in 3-4% of patients presenting with ocular complaints (alotaibi et al, 2011). however, the equipment and expertise required to adequately assess for conditions such as retinal detachment are limited in busy emergency departments due to the time consuming and challenging nature of the examination. incorporating the use of an ultrasound could provide a more available, focused, and timely assessment.

Eligibility criteria:
inclusion criteria: clinical suspicion for retinal detachment age \>18 years of age ophthalmology consult exclusion criteria: concurrent ocular trauma ruptured globe pregnancy \< 18 years of age no ophthalmology consult