Kornimate/medical-research-clean huggingface dataset:
effectiveness of topical antibiotic prophylaxis in inguinal hernia repair

Conditions: Inguinal Hernia

Summary: aim of this study is to measure the effectiveness of topical gentamicin to prevent post-operative infection in inguinal tension-free hernia repair operation.secondary aim is, if it is effective as a prophylactic agent, to compare it's effect with intra venous single dose cefazolin sodium prophylaxis.

this study is a single blind prospective randomized trial. to measure and compare the effectiveness intra-operative topical gentamicin application in tension-free inguinal hernia repair in contrast to intravenous peri-operative prophylactic cefazolin sodium and combination of gentamicin and cephazolin this study is designed. the patients are grouped randomly in to two groups: * group1;intravenous cefazolin sodium * group2;topical gentamicin * group3:topical gentamicin and intravenous cefazolin sodium as a control group we decided to use the data of control groups ( without any prophylactic agent usage ) of previous studies done in our clinic and medical data base reviews.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of inguinal hernia exclusion criteria: * femoral hernia * emergency cases

Keywords: inguinal hernia infection prophylaxis topical gentamicin
cryo-ultrasound versus laser therapy on ankle sprain in tennis players

Conditions: Ankle (Ligaments); Instability (Old Injury)

Summary: the effect cryo-ultrasound therapy and laser therapy on the short-term recovery of tennis players with acute lateral ankle sprains.

acute lateral ankle sprains are common injuries among athletes, but the optimal treatment strategies in elite athletes are still debated. this proof-of-concept study aimed to assess the impact of cryo-ultrasound therapy and laser therapy on the short-term recovery of tennis players with acute lateral ankle sprains.

Eligibility criteria:
inclusion criteria: * age ranged from 12-16 years. * elite girls; * semi-professional tennis players; * i-ii grade lateral ankle sprain injury; * no persistent instability phenomena or chronic sprains; * acute injury (within 2 weeks from trauma); * no evidence of bone edema or skin disorder, once the area of intense pain in motion was delimited, the lack of neurological disturbances was investigated and assessed. exclusion criteria: * history of recurrent dislocation of the ankle or hyperlaxity of any joint; * severe rheumatic diseases and/or collagen diseases; * athletes who have received any form of local physical therapy and nsaids within the last 2 months prior to injury; * athletes who admit to using steroids; * any contraindication and/or limitation to the use of a physical agent modality (implantable electrophysiological devices, active neoplasms). taking medications. * athletic adult.

Keywords: cryoultrasound laser ankle sprain tennis players elite girl
artificial intelligence (ai) analysis of synchronized phonocardiography (pcg) and electrocardiogram(ecg)

Conditions: Heart Failure

Summary: the diagnosis of depressed left ventricular ejection fraction (dlvef) (ef\<50%) depends on golden standard ultrasound cardiography (ucg). a wearable synchronized phonocardiography (pcg) and electrocardiogram (ecg) device can assist in the diagnosis of dlvef, which can both expedite access to life-saving therapies and reduce the need for costly testing.

the synchronized pcg and ecg is wirelessly paired with the wenxin mobile application, allowing for simultaneous recording and visualization of pcg and ecg. these features uniquely enable this device to accumulate large sets of acoustic data on patients both with and without heart failure(hf). this study is a case-control study. in this study, the investigators seek to develop an artificial intelligence (ai) analysis system to identify dlvef (ef\<50%) by pcg and ecg. all adults (aged ≥18 years) planned for ucg were eligible to participate (inpatients and outpatients). specifically, the investigators will attempt to develop machine learning algorithms to learn synchronized pcg and ecg of patients with dlvef. then we use these algorithms to identify dlvef subjects. the investigators anticipate to demonstrate the wearable cardiac patch with synchronized pcg and ecg can reliably and accurately diagnose dlvef in the primary care setting.

Eligibility criteria:
inclusion criteria: * attendance at ruijin hospital for ucg * signed dated informed consent * commit to follow the research procedures and cooperate in the implementation of the whole process research * ucg has been completed * age ≥ 18 * at least 8 consecutive cycles of sinus rhythm can be recorded exclusion criteria: * patients with pacemakers * complete left bundle branch block or block or qrs wave widening\>120ms * left chest skin damaged or allergic to patch * refusal to participate

Keywords: phonocardiography (pcg) electrocardiogram (ecg) heart failure (hf) depressed left ventricular ejection fraction (dlvef)
robot-assisted cognitive training for lonely older adults with mild cognitive impairment (mci)

Conditions: Cognitive Change; Cognitive Impairment, Mild; Aging

Summary: this study will use a socially assistive robot to deliver cognitive training in the form of a music (piano) learning intervention to socially isolated older adults with mild cognitive impairment.

cognitive training has been shown in past research to improve cognitive function in older adults with and without mild cognitive impairment. music learning has been previously shown to be a particularly effective form of cognitive training: in addition to the cognitive demands of learning notation, hand positioning, coordination and timing, those who engage in music learning also benefit from emotional connection to the music and social engagement with a music teacher. not all older adults are able to access music lessons. older adults who are homebound, live in rural areas and do not have access to reliable transportation (or a monthly income with sufficient funds for recurring payments for lessons) are unlikely to be able to access these benefits. socially assistive robots that can deliver both education and companionship on an ongoing basis within the home environment may be a viable solution to these limitations. the purpose of this study is to deliver cognitive training in the form of a music (piano) learning intervention to older adults who are socially isolated, and who may be able to benefit from the cognitive training aspects of the intervention. a socially assistive robot will deliver the intervention.

Eligibility criteria:
inclusion criteria: * be able to speak, read and write in english with a high degree of fluency * cumulative music learning experience \< 3 years * able to sit upright for two hours at a time * able to see images on a screen at a distance of approximately 20 inches * must have independent transportation to and from the institute of gerontology, weekly, for 27 weeks * no hearing impairment beyond what is correctable via hearing aid * must have a safe location in the home to store and use an 88-key keyboard + stand and piano bench * no more than mildly cognitively impaired: global deterioration scale no higher than 2-3; clinical dementia rating scale no higher than 0.5 (sum of boxes) * must have a close companion, family member or loved one who can attend the first and last visit * must be capable of providing informed consent (based on responses to questions on study purpose, tasks, benefits, incentives and risks). * must have a computer or tablet that is connected to broadband internet, to be used three times over the course of the study * must have access to an e-mail account that can be checked three times during the study exclusion criteria: * no previous diagnosis of alzheimer's disease or related dementias * no condition that limits movement of the hands or fingers

Keywords: cognitive training socially assistive robotics music learning
a 5 treatment period pharmacokinetic study evaluating dose proportionality and food effects of diazoxide choline controlled-release tablet (dccr)

Conditions: Prader-Willi Syndrome

Summary: open label, parallel-group, single site, 5 treatment-period study with 4 dose levels of dccr, 1 of which is administered both with and without food.

open label, parallel-group, single site, 5 treatment-period study with 4 dose levels of dccr, 1 of which is administered both with and without food, with a 10 day washout period between treatments. there will be 8 treatment sequences with 4 subjects randomized to each.

Eligibility criteria:
inclusion criteria: * ability to follow verbal and written instructions * informed consent form signed by the subject * completed screening within 7 days prior to dosing * bmi between 18.5 and 35 kg/m2 * generally healthy * fasting glucose less than or equal to 100 mg/dl * hba1c less than or equal to 6% exclusion criteria: * pregnancy or breast feeding * absence of contraception * administration of investigational drug within 1 month prior to screening * anticipated requirement for prohibited medication (systemic corticosteroids or anti-diabetic medications) * allergic reaction to or significant intolerance of diazoxide, thiazides or sulfonamides * known type 1 or type 2 diabetes mellitus * congestive heart failure * gastric bypass surgery * history of drug or alcohol abuse
feeding study in premature infants

Conditions: Premature Infants

Summary: to evaluate weight gain of preterm infants fed fortified human milk.


Eligibility criteria:
inclusion criteria: * premature infant * birth weight less than/equal to 1250 g * exclusively breast fed exclusion criteria: * metabolic or chronic disease * major surgery * ventilator dependent

Keywords: premature infants
effectiveness of sealing dental caries

Conditions: Dental Caries

Summary: this study aims to evaluate, through a controlled clinical randomized study, the effectiveness of sealing carious lesions with composite resin in primary molars. for this, healthy children (n=100) with caries lesion reaching to the middle third of the dentin of primary molars, will be submitted to different treatments to remove the lesions. these patients will be randomly allocated in the following treatment groups: (1) cavity sealing (non-invasive resin based dental sealing) without caries removal; and (2) partial caries removal and invasive resin based restoration. the clinical and radiographic success of the treatment groups will be verified by periodic examination of the restorations by usphs criteria and radiographic subtraction, respectively, which will be checked progression or not of injury. the researcher responsible for these assessments will be blind to the study, whose evaluations will occur after 6, 12, 24 and 36 months of treatment.

the present study will be carried out as a randomized clinical study. primary, occlusal caries lesions in children, aged 3-8 years old will be treated by non-invasive resin based sealing (n= 50) or resin based restoration (n=50). randomization between sealing and restoration (1:1) was made by for a resercher at the federal university of rio de janeiro and kept at the clinics in sealed envelopes. the treatments will be examined clinically and radiographically after 6, 12, 24 and 36 years. the treatments are performed and controlled by only one practitioner (the main reseacher of this study) from the federal university of rio de janeiro, brazil. sealing: the dentist will use a resin based sealing, and follow their usual clinical procedures based on the instructions from the manufacturer and the guidelines from the department of pediatric dentistry and orthodontics of federal university of rio de janeiro, brazil. restoration: the dentist will use preparation design and a resin based resin restoration, and follow their usual clinical procedures (partial caries removal) based on the instructions from the manufacturer and the guidelines from department of pediatric dentistry and orthodontics of federal university of rio de janeiro, brazil. the prevalence of regression, arrest and progression of sealed and restored caries lesions, are computed and related to the clinical and radiological registrations of children, or treatment related factors for assessing of statistically significant correlations. the influence of each factor on the longevity and need for retreatment of occlusal sealants and restorations, will be assessed using apropriate analyses for statistical treatment of data.

Eligibility criteria:
inclusion criteria: * children with good general health; children with caries lesion reaching to the middle third of the dentin of primary molars exclusion criteria: * patients with systemic diseases; patient' guardians who did not consent with the study.
observational study to establish patient-matched population norms for the multiple sclerosis cognition assessment battery

Conditions: Healthy

Summary: the primary objective of the study is to develop ms patient-matched healthy population norms for the multiple sclerosis cognition assessment battery (ms-cog) that are representative of the united states (us), france, and italy.


Eligibility criteria:
key inclusion criteria 1. ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use confidential health information in accordance with national and local subject privacy regulations. 2. must be in good health as determined by the investigator, based on medical history, physical examination, and screening evaluations. 3. must be a native language speaker of the country where the study is being conducted. key exclusion criteria: 1. neurological illnesses/conditions, such as motor or vocal tics (including a diagnosis of tourette's syndrome), head trauma with significant loss of consciousness (\>30 min), cerebral ischemia, carotid artery disease, epilepsy, brain tumor, dementia (including mild cognitive impairment and alzheimer's disease), chronic meningitis, multiple sclerosis, pernicious anemia, normal-pressure hydrocephalus, hiv infection, parkinson's disease, and huntington's disease. 2. medical illnesses/conditions that may affect brain function, such as untreated hypertension (blood pressure \>140/100 mm hg), cardiac disease, insulin-dependent diabetes mellitus, endocrine disorders, renal disease, glaucoma, and chronic obstructive pulmonary disease. 3. major psychiatric disturbance according to the diagnostic and statistical manual of mental disorders, 5th edition (us) axis i criteria \[american psychiatric association 2013\] and the international statistical classification of diseases and related health problems, 10th revision axis i criteria (europe) \[who 2010\]. 4. history of developmental disorders. note: other protocol defined inclusion/ exclusion criteria may apply.
body composition and fatty liver disease

Conditions: Fatty Liver

Summary: this study investigates relationship between fatty liver prognosis and body composition analysis result based on non-contrast low dose ct in patients with fatty liver disease.


Eligibility criteria:
inclusion criteria: * metabolic dysfunction-associated fatty liver disease (fatty liver with overweight/obesity, or type ii dm or other metabolic dysfunction) * or non-alcoholic fatty liver disease with liver function test abnormality * signed informed consent exclusion criteria: * chronic hepatitis b or c * other disease related to fatty liver such as glycogen storage disease, lipodystrophy, familial combined hyperlipidemia, hypobetalipoproteinemia, weber-christian syndrome or abetalipoproteinemia * on medication related to hepatic steatosis (tamoxifen, steroid, valproic acid, methotrexate, amiodarone) * diabetes after pancreatectomy * history of total parenteral nutrition in 6 months * pregnancy or nursing mother

Keywords: ct
proof of concept of pediatric and adolescent explorer v2 exoskeleton in children with neurological and neuromuscular disease

Conditions: Cerebral Palsy; Acquired Brain Injury; Neuromuscular Diseases in Children

Summary: the goal of this clinical trial is to analyze the usability and safety of the prototype gait exoskeleton explore v2 in children with neurological and neuromuscular disease. participants will use the exoskeletons in their home and the community and variables regarding safety and usability will be measured and recorded.

neurological and neuromuscular diseases are the main cause of motor disability in children, leading to the inability to stand and walk in many cases. exoskeletons are a useful tool in the rehabilitation of these children, but most of them are designed to be used in the clinical setting. explorer v2 is a prototype of a robotic gait exoskeleton designed to assist gait in children with motor disability in their homes and the community. the aim of this study is to analyze the safety and usability of the explorer v2 as a proof of concept. a test phase will be conducted in healthy volunteers (phase 0) as a proof of concept with the aim of evaluating safety and usability in healthy participants prior to the use of the device in children with neurological and neuromuscular disease (phases 1 and 2). after this, participants will use the exoskeleton in 4 different ocassions, 1 in a laboratory of gait analysis and 3 in their homes and the community.

Eligibility criteria:
inclusion criteria: * medical authorization for standing, gait training and weight bearing. * informed consent signed by legal guardians. * maximum user weight of 35 kg. * hip width (between greater trochanteres) ≤40 cm. * length of the thigh (distance from the greater trochanter to the lateral condyle of the tibia) from 21cm to 36cm. * tibia leg length (distance from the lateral condyle of the tibia to the lateral malleolus) from 20cm to 35cm. * shoe size ≤38 (eu) exclusion criteria: * spasticity equal to 4 on the modified ashworth scale at the time of use of the device. * more than 20º of hip and/or knee flessum at the time of using the exoskeleton. * necessity to walk with 15 of hip abduction. * skin lesion on parts of the lower extremities that are in contact with the device. * scheduled surgery scheduled during the study period. * history of fracture without trauma. history of bone fracture traumatic in lower extremities or pelvic girdle in the last 3 months. * presence of other conditions causing exercise intolerance (such as uncontrolled hypertension, coronary artery disease, arrhythmia, congestive heart failure, severe pulmonary disease). * conductual disorders that may interfere with the use of the device or their participation in the study, like impulsiveness or the inability to understand simple comands. * allergy to any of the explorer materials: cotton, nylon, polyester, pps, peek or abs.

Keywords: exoskeleton cerebral palsy acquired brain injury neuromuscular disease gait rehabilitation
fluid balance in the icu - interventions to minimize fluids in patients with septic shock

Conditions: Septic Shock; Fluid Therapy; Hypotension

Summary: the purpose of the study is to determine if a protocol that assesses patients' daily fluid intake and output can decrease the overall amount of fluid patients receive during the first five days in the icu. the study will also determine if decreasing overall fluids can decrease adverse events associated with mechanical ventilation, such as ventilator-associated pneumonias. the protocol will include daily ultrasounds and blood draws to evaluate fluid balance. ultrasound will be used to measure changes in the diameter of the inferior vena cava with respiration.


Eligibility criteria:
inclusion criteria: 1. adult patient with septic shock as the primary cause of hypotension 2. requiring vasopressors for 12 hours after adequate fluid resuscitation and at the time of enrollment exclusion criteria: 1. patients with a history of end-stage renal disease requiring outpatient dialysis 2. patients whose goals of care are consistent with comfort measures only 3. pregnant patients
comparison of two rapid antigen detection tests for the detection of group-a streptococcal pharyngitis in children

Conditions: Pharyngitis

Summary: group a streptococcal (gas) pharyngitis in children represents a frequent diagnostic challenge in pediatric emergency departments, since isolated signs and clinical prediction rules are insufficient to accurately discriminate between gas and non gas infections. rapid antigen detection tests (radts) therefore remain essential, simple and rapid tools, allowing for rapid gas identification and prompt antibiotic prescription. however, their sensitivity is not optimal. the aim of the present study is to test the accuracy of a new fluorescent immunoassay (sofia strep a fia) using the optical technology for gas detection in children 3-15 years old with pharyngitis, compared to a standard radt, using throat culture as the gold standard (or pcr for discrepant results, i.e. negative culture with any positive radt).


Eligibility criteria:
inclusion criteria: * patient age between 3 and 15 years * clinical diagnosis of pharyngitis * mcisaac score ≥2 exclusion criteria: * antibiotic treatment in the two weeks preceding the consultation

Keywords: gas pharyngitis children radt
patient satisfaction and pain control following reconstructive vaginal surgery

Conditions: Post Operative Pain

Summary: the investigators hypothesize that patient controlled analgesia (pca) provides superior pain relief and patient satisfaction when compared to scheduled intravenous analgesia following vaginal reconstructive surgery.

the investigators hypothesize that patient controlled analgesia (pca) provides superior pain relief and patient satisfaction when compared to scheduled intravenous analgesia following vaginal reconstructive surgery. in order to determine if there is a significant correlation, secondary outcomes will include the daily and total narcotic volume used, common side effects from the opioid including nausea, vomiting, or pruritis, length of hospital stay, timing of flatus and first bowel movement, all complications, and procedure performed.

Eligibility criteria:
inclusion criteria: * the patients will be limited to those from the division of urogynecology to ensure similar surgical techniques. they will be between the ages of 18 and 70 and undergoing major vaginal reconstruction. * all patients must undergo vaginal reconstructive surgery including: anterior repair, posterior repair, and intraperitoneal vaginal vault suspension. the addition of vaginal hysterectomy, enterocele repair, or suburethral sling is not cause for exclusion. exclusion criteria: * any patient who has an allergy to hydromorphone/dilaudid. * any patient already taking chronic opioids, defined as daily use. * all patients with renal insufficiency or failure. * all patients with liver failure. * any patient who is not having general anesthesia. * any patient undergoing abdominal or laparoscopic procedures: sacral colpopexy, laparoscopic hysterectomy or oophorectomy, burch procedure, or any procedure that enters the abdominal fascia.

Keywords: vaginal reconstructive surgery