Kornimate/medical-research-clean huggingface dataset:
periodontal ligament stem cell implantation in the treatment of periodontitis

Conditions: Chronic Periodontitis

Summary: cell sheet technique possess the properties of conserving the ecm, rich molecules and retaining cell vitality, and will promote the capacity of cell adhesion and proliferation. the stem cell based cell sheet therapy has been utilized in many fields and scored the satisfactory results. periodontitis is a chronic disease which causes the destruction of the periodontal tissue and leads to the teeth loss in the end. the routine cell-based therapy to the periodontitis was confronted with many difficulties. in the investigators previous preclinical research, +the investigators fabricated periodontal ligament stem cell (pdlsc) pellets and cell sheet fragment and applied them in the periodontal defect area for tissue regeneration and periodontitis treatment. and the investigators carried out a comprehensive study of the pdlsc allograft. the host responses and implanted cell fates were recorded. after the scientific investigation of the preclinical study, the investigators designed the preliminary clinical trial of pdlsc cell sheet for the chronic periodontitis therapy in the aims to test the pdlsc fates and explore one ideal transplantation mode.

our protocol mainly includes following steps: 1. select periodontitis patients :all patients were given the comprehensive examination on the oral condition including clinical examination, radiological evaluation and the immune system tests 2. select healthy donor teeth for pdlsc isolation and expansion. 3. fabricate the cell sheet and prepare the pdlsc cell sheet pellets and cell sheet fragment. 4. patients given the routine mechanical and chemical treatment for 4 weeks were randomized divided into 4 groups according to the visit time: i) the cell sheet fragment plus bio-ss transplantation; ii) the cell sheet pellets plus bioss transplantation; iii) the bio-ss transplantation and iv) the control. 5. all the operations were carried out as the routine gbr procedures. 6. the clinical, radiological examination and the changes of the immune system at the point of 1 day before and 4weeks, 12weeks, 24weeks and one year after the intervention were recorded and compared.

Eligibility criteria:
inclusion criteria: 1. adult chronic periodontitis 2. pathological lesion is stable after the routine mechanical and chemical treatment. 3. the local pathological lesion has the subbony defect 4. the oral heath was kept approved. 5. there are more 2 teeth with the continued lesion exclusion criteria: 1. the age\>50 year or \< 40year 2. the patient has the genetic background of the periodontitis. 3. the bone destruction was larger than 2/3 of the root length. 4. the preclinical treatment was stable. 5. the severe systematic diseases. 6. the patients who can not cooperate with the whole the observation.

Keywords: cell sheet pdlsc periodontitis
developmental origins of attention deficit hyperactivity disorder

Conditions: Inattention; Impulsivity; Anxiety

Summary: this is a study evaluating the relationship between prenatal nutrition and neural development in infants born to mothers with attention deficit hyperactivity disorder (adhd). we are hypothesizing that women randomized to a whole food, nutrient-dense diet during their 3rd trimester of pregnancy will have infants with more advanced neural development as compared to infants born to mothers receiving standard-of-care treatment.

pregnant women with adhd will be recruited from the patient population at oregon health \& science university (ohsu). they will be recruited during their 1st or 2nd trimester. after consent, baseline measures will be collected including height, weight, body composition measurements using calipers, 24-hour dietary recalls, and blood and urine samples. women will also complete questionnaires regarding adhd symptoms, stress, depression, and lifestyle. women will be given a one-week food diary to fill out at home, which will be mailed in upon completion. upon receipt of the food diary, women will be randomized into either a nutrition intervention group or a standard-of-care group. women who are randomized to the intervention group will receive individual nutritional counseling every 2 weeks during their 3rd trimester of pregnancy. before delivery, the baseline measures described above will again be collected. at delivery, placenta and cord blood samples will be taken. after birth, the infant will undergo an mri between 2 and 5 weeks of age. the scan is completed while the baby sleeps, and special ear protection is worn to limit sleep disruption from the noise of the mri. when the infant is 3 months old, mothers will complete questionnaires about infant feeding, sleep and behavior.

Eligibility criteria:
inclusion criteria: * women in general good health * 18 years of age or older * confirmed pregnancy and currently between 8 and 24 weeks pregnant * with symptoms of inattention or impulsivity exclusion criteria: * obstetrician confirmed high-risk pregnancy * current drug/alcohol addiction * current smoker * unwilling/unable to discontinue psychiatric medication during pregnancy * comorbid schizophrenia, bipolar, or major depressive disorder

Keywords: attention deficit and hyperactivity disorder nutrition diet developmental origins of disease
d-limonene +radiation +platinumbasedchemo for xerostomia prevention in locallyadvanced hnscc

Conditions: Xerostomia

Summary: this study explores the safety of d-limonene, a commercially-available dietary supplement (food) as a potential therapeutic for the severe dry mouth (xerostomia) experienced by patients with head and neck cancer as a side effect of their anti-cancer treatment.

primary objective:to determine the maximum tolerated dose (mtd) of d limonene when combined with radiation and platinum based chemotherapy in subjects with loco regionally advanced head and neck squamous cell carcinoma (hnscc) based upon dose limiting toxicity (dlt) secondary objective: * to evaluate the feasibility and subject compliance with adjuvant administration of d limonene daily up to a maximum of 4 months after completion of chemoradiation * to correlate the level of d-limonene measured in the plasma to the dose levels(s) administered to the subject * to correlate the level of d limonene measured in the plasma to saliva flow rate and xerostomia questionnaire scores in subjects enrolled in this trial

Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed diagnosis of advanced loco regional squamous cell carcinoma of the nasopharynx (ajcc v8 stage ii iv); oropharynx (ajcc v8 stage i iii for hpv+ cancer, excluding t1 2n0; ajcc v8 stage iii iv for human papillomavirus (hpv) negative cancer); larynx (ajcc v8 stage iii to iv); or hypopharynx (ajcc v8 stage iii to iv), scheduled to undergo chemoradiation. patients with squamous cell carcinoma of the head and neck from an unknown primary site with involved nodes (n1 to 3) also qualify. * scheduled to received definitive rt with concurrent platinum based chemotherapy at stanford * eastern cooperative oncology group (ecog) performance status (ps) 0 to 1 * must be able to swallow d limonene gelcaps at the time of enrollment. * adequate hepatic function within 2 weeks prior to registration defined as follows: bilirubin ≤ 2 mg/dl; aspartate aminotransferase (ast) or alanine aminotransferase (alt) \< 3 times the upper limit of normal * adequate hematologic function within 2 weeks prior to registration defined as follows: * absolute neutrophil count (anc): ≥ 1,500/mm3 * platelets: ≥ 100,000/mm3 * hemoglobin: ≥ 8.0 g/dl (note: the use of transfusion or other intervention to achieve hgb ≥ 8.0 g/dl is acceptable). * adequate renal function defined as follows: serum creatinine ≤ 1.5 mg/dl within 2 weeks prior to registration or creatinine clearance (cc) ≥ 50 ml/min within 2 weeks prior to registration determined by 24 hour collection or estimated by cockcroft gault formula: ccr male = \[(140 - age) x (wt in kg)\] \[(serum cr mg/dl) x (72)\] ccr female = 0.85 x (crcl male) * negative serum pregnancy test within 2 weeks prior to registration and agreement to use a birth control method during the entire duration of d limonene treatment for women of childbearing potential * ability to understand and the willingness to sign a written informed consent document exclusion criteria: * history of allergic reactions attributed to citrus fruits * pregnant or lactating
acute effect of sound healing on pain, fatigue and mood

Conditions: Pain; Fatigue; Mood Change

Summary: there is evidence that sound healing improves health and well-being. however, sound healing modalities, such as tuning forks, continue to be understudied, especially among people with chronic illnesses. this study examined responses to a single session of sound healing and explored whether responses varied based on analogue pain, fatigue, and mood.


Eligibility criteria:
inclusion criteria: * people with long term illnesses who attended 'tuning for health' virtual session exclusion criteria: * who did not complete 30-mins sound healing

Keywords: sound healing with tuning forks
scooter board activities in diplegic cerebral palsy

Conditions: Diplegia

Summary: children with cp may have muscle weakness, changes in mobility, posture, muscle tone, motor coordination and deficits in postural control. these changes, individually or collectively, affect psychomotor function. as a result, activities that are performed quickly and readily by healthy children may be difficult and time-consuming for children with cp.

similar vestibular stimulation can be provided with ascooter-board which requires more active participation on the part of the child. a scooter-board is simply a wooden board mounted on four castors so that it can roll freely and spin in any direction, it should be big enough to support the middle part of the body while the head, upper chest and legs hang off the ends.

Eligibility criteria:
inclusion criteria: 1. cp with a diplegia 2. age 7 to 11 years 3. grade 1and 2 according to the modified ashworth scale (rw and smith, 1987). 4. they could walk with limitation or holding on according to gmfcs (level i\&ii \&iii) (palisano et al., 1997). 5. they were able to understand and follow verbal instructions exclusion criteria: 1. children with any surgical interference in the upper limb. 2. intellectual disability such that simple tasks could not be understood or executed. 3. children with any visual or auditory problems. 4. children with any surgical interference in the lower limb. 5. children with any structural deformities in joints and bones of lower limbs. 6. children who suffer from other diseases or associated disorders that interfered with physical activity.

Keywords: diplegia cerebral palsy core stability trunk control
european multicenter study radiofrequency (rf) versus cryo in atrioventricular nodal reentry tachycardia (avnrt)

Conditions: Atrioventricular Nodal Reentry Tachycardia

Summary: in this randomized study, two energy sources for the ablation of av nodal reentry tachycardia are compared: the standard technique of radiofrequency energy delivery is compared with the new approach of cryo-energy application.

the ablation of av nodal reentry tachycardia with radiofrequency (rf) energy delivering catheters is a standard procedure and in experienced ep laboratories, the safety and efficacy of this approach is very high. however, the potential complication of higher degree av conduction block, requiring in some instances implantation of a pacemaker, is a major drawback of this approach. we want to compare in this randomized study the safety and efficacy of standard rf ablation with the cryo-ablation technique. this relatively new technique is thought to offer more safety concerning higher degree av conduction block.

Eligibility criteria:
inclusion criteria: * age between 18 and 80 years old * clinical diagnosis of avnrt (ecg/patients history) * electrophysiologically confirmed (invasively assessed) diagnosis of avnrt * written informed consent exclusion criteria: * prior ablation for avnrt * congenital heart disease interfering with the ablation method * prior cardiac surgery * medical or psychiatric disorder interfering with study protocol or data acquisition * exclusion of the patient by the study investigator
effects of fetal positioning during venipuncture

Conditions: Preterm Neonates; Venipuncture

Summary: the study was aimed to examine the effects of fetal positioning during venipuncture on the neonates' pain score and physiological parameters (heart rate, blood-oxygen saturation, body temperature, crying duration) in neonatal intensive care unit (nicu). this randomized controlled clinical trial was conducted between 10.2021-07.2022 with 60 preterm neonates, aged 26-32 week of gestation. neonates were divided into intervention group (n=30) and control group (n=30) according to the randomization method. the neonates in the intervention group were put into fetal positioning at least 10 minutes before the procedure, and then venipuncture was performed. the fetal positioning was maintained throughout the procedure and the patient was kept in the fetal position for at least five more minutes after the procedure. changes in the neonates' pain score and crying duration as well as heart rate, blood temperature, blood-oxygen saturation at three time points: before the procedure, immediately after needle insertion, five minutes after needle removal. data was collected using the sociodemographic form, neonatal observation form and neonatal pain, agitation and sedation scale (n-pass). the collected data were analyzed using the spss 15 software. the main questions it aims to answer: 1. does fetal positioning have an effect on pain score of premature neonates? 2. does fetal positioning have an effect on heart rate of preterm neonates? 3. does fetal positioning have an effect on oxygen saturation of preterm neonates? 4. does fetal positioning have an effect on body temperature of the preterm neonates? 5. does fetal positioning have an effect on the crying duration of preterm neonates?

neonates who were hypotonic, lethargic, in shock or had seizures, stage 3-4 intracranial hemorrhage and a history of surgery were not included in the study. additionally, neonates was taken any analgesic and/or sedative in the last 24 hours were excluded from the study.

Eligibility criteria:
inclusion criteria: * premature newborns (a) whose parents volunteered to participate in the study, (b) required venipuncture, and (c) were born at 26-32 gestational weeks were included in the study. exclusion criteria: * newborns who are hypotonic, lethargic, in shock or having seizures, * newborns with a history of stage 3-4 intracranial hemorrhage * newborns with a history of surgery * newborns whose gestational week is over 37 weeks * newborns who have taken any analgesics and/or sedatives in the last 24 hours, * newborns who have had any invasive procedure within the last hour * newborns whose parents do not volunteer

Keywords: preterm neonates venipuncture fetal positioning pain physiological parameters nursing
muscle training with and without vascular occlusion of women with patellofemoral pain syndrome: a random clinical trial

Conditions: Patellofemoral Pain Syndrome; Vascular Occlusion

Summary: introduction: the treatment of patellofemoral pain syndrome (pfps) uses the strengthening of the knee and hip muscles. studies propose the use of partial vascular occlusion (ovp) of the quadriceps muscle to increase muscle strength and endurance, without joint overload or discomfort to the patient. however, there is no consensus on the use in individuals with pfps. objective: to establish the effect of quadriceps muscle strengthening with ovp and low resistance to exercise on pain, functionality, postural control and muscle recruitment in women with patellofemoral dysfunction. methods: women with pfps (n = 20) will respond to pain and functionality scales. the postural control and muscle recruitment of the quadriceps will also be evaluated in dynamic activities of single-legged squat and up / down stairs using a force platform and surface electromyography. after the initial assessment, the participants will be randomized into two groups: conventional quadriceps strengthening with greater resistance loads to exercise and quadriceps strengthening with ovp and low loads. and they will perform a six-week treatment protocol with exercises to strengthen the quadriceps. at the end of the intervention protocols, all of them will be reassessed immediately, after four and eight weeks. expected results: it is expected that the group submitted to exercises with ovp and lower load will present the same results of postural control and muscle recruitment compared to the conventional strengthening group. these results will indicate the possibility of using exercises and loads with less joint impairment.


Eligibility criteria:
inclusion criteria: insidious onset of symptoms unrelated to trauma, pain for at least three months; pain greater than three (3/10) in at least three of the functional activities (squatting for a long time, going up or down stairs, kneeling, running, remaining in a sitting position for a long time), maximum 86 points on the anterior knee pain scale (akps). exclusion criteria: signs and symptoms of other coexisting knee pathologies (arthrosis, prostheses, meniscal and ligament injuries), pain in other joints of the lower limb; lumbar spine pain, neurological, rheumatological, vascular and metabolic diseases; pregnancy; history of lower limb surgery; corticosteroid injection in the knee applied in the last three months, physiotherapy for knee rehabilitation in the last six months.

Keywords: patellofemoral pain syndrome partial vascular occlusion postural balance electromyography physical therapy.
electromechanical profiling of the long-qt syndrome (lqts)

Conditions: Long QT Syndrome; Sudden Cardiac Death; Ventricular Tachycardia

Summary: high-resolution, non-invasive electromechanical mapping in genotyped long-qt syndrome patients and healthy controls at baseline and during smart provocation.

using simultaneous ecg-imaging, speckle-tracking analysis and tissue-phase mapping with mri we will assess electromechanical dispersion at rest. regional electromechanical elasticity will be investigated during adenosine and epinephrine, isoprenaline infusions and is postulated to increase sudden cardiac death risk prediction in the individual patient.

Eligibility criteria:
inclusion criteria: lqts group (group 1): * diagnosis of lqts according to the esc guidelines. * genetic testing either already performed or consent to genetic testing (at least 5 major lqts-related genes tested: kcnq1, kcnh2, scn5a, kcne1, kcne2). control group (group 2): \> control subjects with structurally normal hearts. exclusion criteria: * pregnancy, nursing or planning to become pregnant. * known allergy or strong reaction to skin electrodes or contrast agent. * inability to give informed consent. * presence of metal objects in or attached to the body. * dialysis. * cardiomyopathy. * second-degree heart block or higher degrees of block. * sick sinus syndrome. * asthma. * chronic obstructive pulmonary disease. * left-main coronary artery disease. * unstable coronary artery disease.

Keywords: electromechanical mapping risk stratification
the safety and tolerability of lbs-007 in patients with relapsed or resistant acute leukaemias

Conditions: Relapsed or Resistant Acute Leukaemias

Summary: the most common types of acute leukaemia are acute lymphoblastic leukaemia (all) and acute myeloid leukaemia (aml). aml is a heterogenous clonal disorder of haemopoietic progenitor cells and the most common and severe malignant leukemia in adults and is responsible for the highest mortality from leukemia. all is a neoplasm characterized by the growth of malignant lymphoblasts of the b or t lineage, leading to an inhibition of proliferation of the normal blood cell lineages. the primary objectives of this study are investigating the safety, tolerability, and the mtd of lbs-007. the secondary objectives are to assess the efficacy and to determine the pharmacokinetics (pk) of lbs-007. the exploratory objective is to study and correlate the changes in surrogate biomarkers in response to treatment.


Eligibility criteria:
inclusion criteria: * male or female subjects greater than 18 years old, inclusive. * pathologically confirmed diagnoses of relapsed or resistant aml or all. * patients who are ineligible for standard therapies that are anticipated to result in durable remission or cure, or who have no known therapy options of documented benefit. * eastern cooperative oncology group (ecog) performance status 0 to 2. exclusion criteria: * concomitant chemotherapy, radiation therapy, or immunotherapy. * receiving any other investigational agents concurrently or within 30 days prior to screening. * patient has acute promyelocytic leukaemia or leukemia with active cns involvement. * history of another active malignancy with 2 years prior to study entry, basal cell skin cancer and previous carcinoma in treated curatively. * patient with mental deficits and/or psychiatric history

Keywords: cdc7 inhibitor lbs-007 aml all
prevalence of sleep apnea syndrome in patients with type 1 diabetes

Conditions: Diabetes Mellitus, Type 1

Summary: obstructive sleep apnea (osa) and type 2 diabetes are two frequent diseases that occur in adult population. the prevalence of osa is higher in people with type 2 diabetes compared with the general population7 ; in addition, the osa syndrome is almost assessed in obese type 2 diabetes. the relationship between osa and type 2 diabetes has been well characterized: the osa can contribute to increased insulin resistance or glucose intolerance; and, diabetes may worsen sleep-disordered breathing because of autonomic neuropathy8,9. the main link between osa and type 2 diabetes is central obesity, which triggers glucose intolerance/insulin resistance and is also an independent risk factor for osa. type 1 diabetes is generally not related to obesity; however, sleep-disordered breathing in these patients was described in few reports early as 1985 by pioneers such as guilleminault5 and the prevalence of osa is estimated at range 10 to 40% in type 1 diabetes patients. few studies had evaluated the prevalence of sleep disorders in particular the sleep apnea syndrome in patients with type 1 diabetes and even less their influence on the glycemic control. this study will take place at the chu of amiens-picardie during a one-night hospitalization. the investigators will study in 44 type 1 diabetes mellitus (iah apnea hypopnea index ≥15) who underwent polysomnography and continuous glucose monitoring of blood glucose


Eligibility criteria:
inclusion criteria: * all patients over 18 years * with type 1 mellitus diabetes exclusion criteria: * type-free diabetes (type 1 slow), * age \<18 years * a poor compliance with the follow-up (meetings unfulfilled without justification). * all patients with known sleep disorders (osa, narcolepsy, idiopathic hypersomnia).

Keywords: sleep apnea syndrome, polysomnography and glucose monitoring continu glycemia (cgms )