Kornimate/medical-research-clean huggingface dataset:
improving health of nurses with burnout through positive psychological intervention

Conditions: Burnout

Summary: burnout is usually regarded as a response to chronic professional stressors like high workload, unfavorable emotion and complex interpersonal relationships. a high prevalence of burnout was found in many countries, and large-scale studies also showed high levels of burnout in chinese nurses. as a stress-related syndrome, burnout was found to have detrimental influences on both psychological and physical health of nurses. psychological problems such as depression and insomnia are verified to be associated with burnout. endocrine dysfunction such as abnormal cortisol secretion rhythm occurred in shift-work nurses. thyroid dysfunction was increasing and a sample of nurses were diagnosed with thyroid nodules and thyroid hormonal disorder during annual physical examination. therefore, it is important to take measures to alleviate nurses' burnout to improve health. positive psychological interventions are defined as treatment methods or intentional activities to enhance person's positive emotions, cognitions and behaviours. in these methods and activities, people are usually required to finish a systematic exercise. according to a recent meta-analysis, positive psychological interventions showed effectiveness in enhancing participants' well-being and reducing depressive symptoms. therefore, this study aims to explore whether positive psychological intervention could reduce burnout and improve health of nurses.


Eligibility criteria:
inclusion criteria: * officially employed licensed nurses; burnout score higher than 1.49; had a telephone on which wechat could be installed. exclusion criteria: * pregnant; current endocrine disorder; taking hormone drugs such as contraceptives.
prevalence of ia and igd disorders among assiut university students

Conditions: Internet Addiction; Internet Gaming Disorder

Summary: identifying the prevalence of internet addiction and internet gaming disorder among assiut university students

internet activities and technologies that are increasing rapidly have attracted young adults, leading to excessive use of the internet and maladaptive internet attitude known as "internet addiction". the term "addiction", even traditionally utilized to describe a physical dependence of substances, has been applied to the excessive use of the internet . internet addiction disorder is expressed as too much computer use that contradicts daily activities and can harm daily function . internet gaming disorder (igd) was included as a nonsubstance addiction in the appendix of the fifth edition of the diagnostic and statistical manual of mental disorders (dsm-5) published in 2013 by the american psychiatric association. the need to add igd to this diagnostic manual was identified by an international expert working group that reviewed over 250 articles, some of which showed the detrimental effects of excessive gaming . as part of the dsm-5 approach to defining igd, draft diagnostic criteria were proposed with some similarities to substance use disorders and added to the appendix of the dsm-5 manual, suggesting igd was a condition warranting further research. the harmful consequences of excessive gaming were also recognized by the world health organization (who), and gaming disorder (gd) was included in their 2018 release of the 11th revision of the international classification of diseases (icd-11) .

Eligibility criteria:
inclusion criteria: * assiut university student active internet user since at least 1 year willing to give consent and complete the questionnaire exclusion criteria: * not willing to give consent and complete the questionnaire
multi-methods study on inclusive cancer diagnosis in people with disabilities and health outcomes

Conditions: Disabled Persons; Cancer Diagnosis

Summary: the micado study is a multi-method study that aims to investigate inclusive cancer diagnosis in people with disabilities and health outcomes. the main objective is to examine variations in cancer diagnosis and outcomes among individuals with psychiatric, intellectual, neurological, and sensory disabilities to develop interventions aimed at improving cancer care. the hypothesis that investigators will investigate is that people with disability are diagnosed with cancer later than people without disability due to a range of barriers, including physical, sensory, cognitive, and social barriers. the study will use a mixed-methods approach, combining quantitative research (electronic health record analysis) and qualitative research (interviews). the total duration of the study is two years.


Eligibility criteria:
inclusion criteria: electronic health record study: * patients with psychiatric, intellectual, neurological, and sensory disabilities who received care at san raffaele hospital of milan between 2011 and 2024 * patients without disabilities who received care at san raffaele hospital of milan between 2011 and 2024 (ratio 4:1 of patients without vs. with disabilities) * patients with psychiatric, intellectual, neurological, and sensory disabilities recorded in the lombardy regional data warehouse between 2011 and 2024 * patients without disabilities recorded in the lombardy regional data warehouse between 2011 and 2024 (ratio 4:1 of patients without vs. with disabilities) * patients aged 18 and over qualitative interviews: * patients aged 18 and over with psychiatric, intellectual, neurological, and sensory disabilities who received care at san raffaele hospital of milan, dama (disabled advanced medical assistance) in territorial social health companies "santi paolo e carlo" and ledha (league for the rights of people with disabilities and the promotion of autonomy) and their caregivers * healthcare provider working at san raffaele hospital of milan, dama (disabled advanced medical assistance) in territorial social health companies "santi paolo e carlo" and general practitioners exclusion criteria: * patients under 18 years of age * patients don't speak the italian language (for the qualitative study)
immunological indices and infections among pesticide applicators in sohag governorate

Conditions: Pesticide Adverse Reaction

Summary: the human body gets exposure to pesticides either directly or indirectly. by using pesticides on crops, humans come in direct contact with them and they affect the heaith immune system is the first defense line against pathogenic organisms; however, it is altered by the vulnerable environmental factors such as pesticides, which can cause structural or functional alterations in humoral or cell mechanisms (nonspecific or adaptive) of the immune response which lead to an increase in the susceptibility to infections


Eligibility criteria:
inclusion criteria: 1. pesticide applicators 2. age ;20-60 years 3. exposure to pesticides for more than 3 months exclusion criteria: * subjects have recent severe trauma or surgery or recent infections
evaluating vr therapy using cold pressor test

Conditions: Pain

Summary: this study is testing whether or not low-cost, virtual reality (vr) headsets for mobile phones can be used as a potential distractor from pain and thus would have clinical applications as a low-cost, non-pharmaceutical method to increase pain tolerance in patients undergoing painful or uncomfortable procedures. to do this, the investigators are asking volunteers to submerge their hand up to the wrist in cold water (cold pressor test), either while playing an interactive virtual reality game on the headset, or while wearing a vr headset that is turned off as a control. the investigators will record the participants' tolerance to cold water as measured by how long the participants are able to keep their hand in the cold water.


Eligibility criteria:
inclusion criteria: * healthy adult mayo clinic students and employees exclusion criteria: * participants who are known to be sensitive to vr technology and/or have undesirable reactions to vr technology (i.e. dizziness, motion sickness) * participants with significant alcohol/smoking histories, sickle cell anemia, history of previous myocardial infarction and/or coronary artery disease, malignant hypertension, metabolic * dysfunctions, pregnancy, raynaud's disease, epilepsy, severe mental disorders, chronic pain conditions, or diseases producing neuropathic pain * participants that have used drugs/alcohol the day prior to the study

Keywords: pain tolerance perioperative pain virtual reality therapy
intraarticular injection of infliximab

Conditions: Arthritis

Summary: intra-articular (ia) injection of medication is a common procedure in the management of joint disorders. in particular, the procedure is effective in the treatment of inflammatory conditions, with long acting corticosteroids most commonly used. these agents have been shown to reduce the signs and symptoms of inflammation, expressed primarily in the synovium of the joint, and are probably capable of slowing the progression of damage to joint cartilage and bone in some of these inflammatory conditions. arthritis that is refractory to ia corticosteroid injections may respond to surgical, chemical, or, radioisotope synovectomy, procedures in which the inflamed synovial tissue is eradicated. it has been noted that infliximab, a monoclonal antibody directed to tumor necrosis factor (tnf) - α, has high affinity for the tnf-α rich inflamed synovium. recently, clinical benefit from ia injections of infliximab has been reported in some cases that were refractory to ia injections of corticosteroids. similarly, the effectiveness of ia infliximab in suppression of joint inflammation has also been demonstrated in patients who could not receive systemic therapy with infliximab. these reports examined the effect of a single injection of infliximab100 mg injected into a large inflamed joint or 2 ia injections 24 hours apart. we propose to further evaluate the use of ia infliximab in patients with intractable knee monoarthritis, explore the optimal mode of its employment, and assess the degree of infliximab systemic absorption from the ia injection. in a pilot study 40 knees will be evaluated, 20 injected with infliximab and 20 injected with a corticosteroid comparator reflecting the current standard of care.


Eligibility criteria:
inclusion criteria: * have non-infectious monoarthritis of the knee and with inadequate response to ia injection of corticosteroids, at least 3 months before enrollment. or * have oligo or polyarthritis controlled by disease modifying agents (dmards) but with residual 1-2 inflamed joints, one of which is a knee with inadequate response to ia injection of corticosteroids within 3 months * have negative ppd skin test. * have no evidence of tb on chest x-ray. * be negative for hbsag and hcv. * no evidence of infectious arthritis exclusion criteria: * known allergy to infliximab. * known allergy to lidocaine. * pregnant. * female patients with childbearing potential who do not practice effective methods of contraception. * suffer from a chronic infection. * on systemic anti tnf-α or other biologic agents

Keywords: intraarticular injection infliximab
compare the efficacy of mepilex and keramatrix in second degree burn wounds

Conditions: Skin Burn Degree Second

Summary: the purpose of this study is to determine the extent to which keramatrix dressing promotes the healing of second-degree burn wounds in pediatric patients.

efficacy in promoting wound healing will be determined through comparison to mepilex, an established burn wound dressing.

Eligibility criteria:
inclusion criteria: patient age 0-18 years old flame or scald burn 10-30% total body surface area burned partial-thickness second-degree burns admission within 72 hours of burn injury clean non-infected wound as diagnosed by the attending physician exclusion criteria: * patient older than 18 * causes other than flame or scald injuries (ie.chemical or frostbite) * wounds noted to be contaminated or infected * patients who have received previous treatment efforts (topical dressings or previous wound debridement) * pregnancy lactation * co-morbidity which may compromise healing: known history of aids, arc, hiv, cancer, autoimmune diseases,cirrhosis, tuberculosis, chronic glucocorticoid therapy, diabetes mellitus, renal insufficiency, hepatic disease, congestive heart failure prior to burn injury, associated severe head injury requiring specific treatment * known allergy to sheep's wool

Keywords: burn second-degree
effects of propofol and sevoflurane on blood folic acid and homocysteine concentrations in children

Conditions: Sevoflurane; Propofol; Homocysteine; Cochlear Hearing Loss

Summary: to investigate the effect of sevoflurane and propofol on the concentrations of serum homocysteine and folic acid in children who received cochlear implant surgery.

this study is a prospective single center, cross-reference clinical application study.this study plan to enroll 40 children with cochlear implant surgery. children were selected randomly and divided into 2 groups.each group has 20 patients. all children undergo orotracheal intubation, mechanical ventilation will given by anaesthetic machine (u.s. ohmeda advance cs2 ) to maintain oxygen saturation above 95%, hemodynamics and other vital signs were monitored with the anesthesia monitor.in the operation room,2-3ml arterial blood will be taken.and the levels of homocysteine and folic acid will be measured at week 1.

Eligibility criteria:
inclusion criteria: * children accepted cochlear implant surgery under general anesthesia * no participate in any other trial up to 3 months before this study * no acute infectious diseases, systemic diseases * willing to participate in this study and sign the informed consent exclusion criteria: * unwilling to participate in this study * with a history of serious liver or kidney dysfunction * hemodynamic instability (etc. shock, blood pressure reduced by 30%) * children with egg milk allergy * children with a family history of malignant hyperthermia

Keywords: sevoflurane propofol folic acid concentrations homocysteine concentrations cochlear implant surgery
evaluation of an adapted physical activity program in patients with unresectable pancreatic cancer

Conditions: Unresectable Locally Advanced Cancer; Metastatic Pancreatic Cancer

Summary: adapted physical activity (apa) program may provide an opportunity to improve symptoms for patients with unresectable pancreatic cancer. thereby, it is proposed to conduct an open trial to assess effects of the apa program in such population

the benefit of adapted physical activity (apa) has been demonstrated after cancer diagnosis in term of symptomatic improvement: reducing fatigue, pain and improving the quality of life, psychological and emotional state, and adherence to treatment. the aim of the study is to assess the effects of an apa program in pancreatic cancer population treated by usual chemotherapy. 200 randomized patients are required. the program is organized in 16 weeks. during the trial, assessments include: aerobic exercises, muscular strength, six-minute walk test, body composition (bioimpedance, l3 ct-scan), level of physical activity - international physical activity questionnaire - (ipaq questionnaire), fatigue - multidimensional fatigue inventory - (mfi-20 questionnaire), quality of life - eortc quality of life questionnaire c-30 - (eortc qlq-30 questionnaire), depression symptom - hospital anxiety and depression scale - (hads questionnaire), pain (brief pain inventory short form), and nutritional evaluation (bmi, ingests eva). furthermore, relationships between insulin resistance, insulin secretion, insulin like growth factor 1 (igf-1) and pancreatic carcinogenesis exist. apa may improve the quality of life in decreasing insulin-resistance, insulin secretion and igf-1.

Eligibility criteria:
inclusion criteria: * histologically proven non resectable pancreatic adenocarcinoma * indication of palliative chemotherapy * life expectancy ≥ 3 months * eastern cooperative oncology group (ecog) - performance status ≤2 * age ≥18 years old * at least one measurable lesion as assessed by ct-scan or mri (magnetic resonance imaging) * identified accompanying partner adapted physical activity (aapa) * signed and dated informed consent * registration in a national health care system (cmu included for france) exclusion criteria: * previous cerebrovascular accident or myocardial infarction \<6months * uncontrolled hypertension. * severe cardiovascular or respiratory disease * severe cognitive or psychiatric disorder * severe motor and/or sensory neuropathy * rheumatologic or orthopedic problem or bone lesions with a fracture risk * others comorbidities contra-indicated physical exercises * patient protected by the law - guardianship and trusteeship

Keywords: unresectable pancreatic cancer gercor adapted physical activity (apa) quality of life fatigue
ultrasound versus palpation for spinal anesthesia success

Conditions: Ultrasound

Summary: aim is to investigate the difference in number of attempts to place neuraxial block comparing handheld ultrasound versus use of palpation alone for women with impalpable bony landmarks undergoing spinal anesthesia for elective cesarean delivery.

patients will be recruited prior to cesarean delivery and their site of lumbar injection will be examined. women with impalpable bony landmarks will be offered recruitment to the study. women will be randomly assigned to the standard of care group - palpation attempts only, versus an ultrasound group, where the insertion point will be identified by the handheld ultrasound device inclusion criteria: lumbar spinous processes impalpable. elective cesarean delivery for singleton pregnancies bmi \>30 no contraindications to neuraxial block signed informed consent neuraxial block planned exclusion criteria refuses informed consent poor written hebrew, no spoken english or hebrew patients will be randomized into two groups : an ultrasound (us) group and a palpation (pp) group. the primary outcome of our study is the number of needle redirections, defined as any ventral advancement of the needle and/or introducer, as well as any new intervertebral space attempted. secondary outcomes include: the insertion site identification time, patient verbal numerical pain score (0-10) after skin incision.

Eligibility criteria:
inclusion criteria: lumbar spinous processes impalpable. elective caesarean delivery for singleton pregnancies bmi \>30 no contraindications to neuraxial block signed informed consent neuraxial block planned

Keywords: ultrasound
effects of expectations and body image in breast reconstruction

Conditions: Breast Cancer

Summary: a breast reconstruction after mastectomy, either due to breast cancer or a high lifetime risk for cancer, is performed to increase the patient's quality of life. however, there are studies that show that some women regret their decision to have breast reconstruction. there are also studies demonstrating similarities in the general patterns of psychosocial adjustment and quality of life among women with breast cancer who have undergone breast-conserving surgery, mastectomy alone, and mastectomy combined with breast reconstruction. hence, it is unclear which women actually beneﬁt from a breast reconstruction. the concept of quality of life is connected to patient satisfaction and body image/investment. therefore, the aim of this project is to examine the effects of patient expectations and body image on the patient reported outcomes of breast reconstruction, to improve preoperative information and postoperative care for women considering a breast reconstruction.


Eligibility criteria:
inclusion criteria: * biological women with breast cancer or high risk for breast cancer who want post-mastectomy breast reconstruction * age \> 18 years exclusion criteria: * inability to give informed consent * inability to understand swedish * relaps of cancer * palliative treatment

Keywords: plastic surgery breast reconstruction complication expectations body image
a study on knee immobilization and pain levels after an anterior cruciate ligament (acl) reconstruction surgery

Conditions: Anterior Cruciate Ligament Reconstruction

Summary: the purpose of the study is to determine if there is difference in immediate postoperative pain levels (48 hours) between patients who wear a knee immobilizer splint compared to patients who do not wear a knee immobilizer splint after an anterior cruciate ligament reconstruction surgery.

this study will attempt to evaluate the efficacy of knee immobilization on patient postoperative pain levels following an acl reconstruction. there is a lack of consensus in the area of postoperative knee bracing/immobilization. a survey of canadian surgeons indicates that the primary reason for postoperative knee immobilization is to reduce pain. to the investigators' knowledge, there are no studies comparing the use of immediate (0-48 hours) postoperative knee immobilization versus no immobilization and pain control in this patient population.

Eligibility criteria:
inclusion criteria: - clinical: patients' aged 18-40, acl deficiency as determined by mri or physical exam (positive lachmann and pivot shift tests) resulting in giving way episodes (acute or chronic) unresponsive to non-operative management and therefore requiring primary acl reconstruction. - arthroscopic: concomitant meniscal resection. exclusion criteria: - clinical: previous surgery on either knee (not including a diagnostic arthroscopy arthroscopy or simple partial meniscectomy,) concomitant lower extremity fracture, ipsilateral collateral ligament injury within past 3 months, time from acl injury less than 6 weeks, allergy/intolerance to tylenol 3 with codeine and to percocet, third party or medical legal. - radiological: skeletal immaturity (open growth plates). - arthroscopic/surgical: concomitant posterior cruciate ligament or collateral ligament repairs, osteochondral lesions requiring microfracture, meniscal repair, patients not having both their semitendinosus and gracilis harvested.

Keywords: anterior cruciate ligament reconstruction knee immobilization postoperative pain
evaluation of the individual early psychoeducation program for schizophrenic disorders in inpatients

Conditions: Schizophrenia

Summary: schizophrenia affects about 0.7% of the population. poor insight, which is common in this disease, linked to poor drug compliance is leads to rehospitalisation with major impact on quality of life. indeed, many patients relapse with exacerbation of symptoms. psychoeducation can improve therapeutic alliance and medication compliance. in this context, an individual psycho-education program (pepits) has been developed. pepits carried out by nurses during the initial stages of hospitalisation. the hypothesis is that pepits program will decrease relapse and improve the compliance and insight and and so the quality of life.


Eligibility criteria:
inclusion criteria: * age between 18 and 65 years * patient with a diagnosed and reported schizophrenic disorder announced : * schizophrenia * schizoaffective disorder * or a diagnosed and reported delusional disorder * express written consent by the participant after receiving information about the study * be able to communicate verbally * participant affiliated to a social security scheme exclusion criteria: * pregnant or breastfeeding woman * patient who does not speak french * participation in a psycho-education group in the last 2 years * patient under legal protection or guardianship