evaluation of long-term neurodevelopment in neonatal encephalopathy by infant treadmill

Conditions: Hypoxic-Ischemic Encephalopathy; Periventricular Leukomalacia; Intraventricular Hemorrhage; Bilirubin Encephalopathy; Kernicterus; Hypoglycemia, Neonatal; Cerebral Infarction

Summary: there is no international application of infant running stimulation system to evaluate the brain injury in children with various stages of nerve and motor development in a large sample of studies. the study of neonatal brain injury is only limited to intraventricular hemorrhage(ivh),periventricular leukomalacia(pvl), down's syndrome(ds), premature birth of these four conditions, and the number of samples in the single digits, there is no representative of the disease population. therefore, from the newborn to the infant development of the critical period, the investigator will refer to the previous treadmill parameters set on the research results, optimize the application of neonatal treadmill. the study hypothesized that neonatal treadmill stimulation with brain-injured children could improve his / her staggered gait characteristics and long-term nerve development through large sample data. it is important to preserve and analyze the gait characteristics and the changes of nerve development in every stage of growth and development of neonates with brain injury so as to provide clinical evidence for rehabilitation intervention. it is of great significance to judge whether this technique can be used in the early stage of brain injury in neonates.

there is no international application of infant running stimulation system to evaluate the brain injury in children with various stages of nerve and motor development in a large sample of studies. the study of neonatal brain injury is only limited to intraventricular hemorrhage(ivh),periventricular leukomalacia(pvl), down's syndrome(ds), premature birth of these four conditions, and the number of samples in the single digits, there is no representative of the disease population. therefore, from the newborn to the infant development of the critical period, the investigators will refer to the previous treadmill parameters set on the research results, optimize the application of neonatal treadmill. the study hypothesized that neonatal treadmill stimulation with brain-injured children could improve his / her staggered gait characteristics and long-term nerve development through large sample data. it is important to preserve and analyze the gait characteristics and the changes of nerve development in every stage of growth and development of neonates with brain injury so as to provide clinical evidence for rehabilitation intervention. it is of great significance to judge whether this technique can be used in the early stage of brain injury in neonates.

Eligibility criteria:
inclusion criteria: 1. gestational age \< 33 weeks; 2. correction of gestational age \< 3 months; 3. it has been diagnosed as hypoxic-ischemic encephalopathy, periventricular intraventricular hemorrhage, periventricular leukomalacia, bilirubin encephalopathy, persistent hypoglycemia and cerebral infarction. 4. there was no other therapeutic intervention before entering the study; 5. informed consent is signed by the family. exclusion criteria: this study is excluded from the study provided that one of the following conditions is met: 1. brain injury caused by central or peripheral infection (cerebrospinal fluid positive / torch test positive / three major conventional culture positive); 2. brain damage caused by convulsion; 3. metabolic brain damage caused by genetic defects; 4. suffering from known severe congenital malformations; 5. definite head trauma during labor or postpartum; 6. peripheral neuromuscular disease or abnormal skeletal system.