Kornimate/medical-research-clean huggingface dataset:
far infrared irradiation for managing, control and treatment of huntington's disease (hd)

Conditions: Huntington Disease

Summary: huntington's disease (hd) is a fatal disease with profound neurological and behavioral features. hd is typically characterized by uncontrollable movements and psychological disturbances. this study will investigate the use of far infrared radiation for control, management and treatment of hd.

observations from our research studies indicate that, far infrared rays provide energy to the body, improve the autonomic functions of the nervous system, restore the functions of the endocrine system, strengthen the immune system, improve blood circulation and increase the level of oxygen in the cells and promote the regeneration of muscle cells, nerves and brain cells. it is hereby postulated that irradiation using far infrared, with wavelength between 5 to 20 microns, of the central nervous system, the endocrine system and the whole body could prevent, control, manage or possibly lead to complete rehabilitation of people who have hd.

Eligibility criteria:
inclusion criteria: * people with hd exclusion criteria: * none

Keywords: akinetic-rigid variant of huntington disease chorea, chronic progressive hereditary (huntington) chronic progressive hereditary chorea (huntington) huntington chorea huntington chronic progressive hereditary chorea huntington disease, akinetic-rigid variant huntington disease, juvenile huntington disease, juvenile-onset
exercise to boost response to checkpoint blockade immunotherapy

Conditions: Cutaneous Melanoma; Cutaneous Squamous Cell Carcinoma; Merkel Cell Carcinoma

Summary: the purpose of this pilot study will be to provide i) information on feasibility implementing an exercise intervention trial among patients with cutaneous cancers, including melanoma, squamous cell carcinoma (cuscc), and merkel cell carcinoma, scheduled to receive checkpoint blockade immunotherapy, and ii) preliminary data on the impact of a day-of-therapy exercise intervention.


Eligibility criteria:
inclusion criteria: 1. males and females ≥18 years of age. 2. able to read and speak english fluently. 3. reported ability to complete 20-30 minutes moderate exercise per positive response to, "can you currently walk unaided for six minutes or more?" 4. scheduled for first-time checkpoint blockade immunotherapy with avelumab, cemiplimab, ipilimumab, nivolumab, or pembrolizumab in the absence of other therapies (e.g. targeted therapy) with the following diagnosis: 1. adjuvant setting: cutaneous melanoma. 2. neoadjuvant setting: cutaneous melanoma, cuscc, or merkel cell carcinoma. 5. states willingness to follow protocol as described, including the prescribed exercise level and completing any forms needed throughout the study. 6. voluntarily signed and dated an informed consent form, approved by an institutional review board/independent ethics committee, and provided health insurance portability and accountability act authorization (hipaa) or other privacy authorization prior to any participation in study. exclusion criteria: 7. presence of medical conditions, such as severe cardiovascular disease for which exercise may be contraindicated. participants may be referred to their medical team to obtain a cardiology approval. 8. presence of major postoperative complications for which an exercise intervention may be contraindicated. 9. currently has a chronic, contagious, infectious disease, such as active tuberculosis, active hepatitis b or c, hiv, or covid-19, per self-report. 10. currently pregnant, lactating or planning to become pregnant (positive result on urine pregnancy testing). 11. presence of any condition that, in the opinion of the investigator, compromises participant safety or data integrity or the participant's ability to complete the study.
effect of interferential l therapy on low back pain

Conditions: Low Back Pain

Summary: background: chronic non-specific low back pain is defined as unknown mechanical musculoskeletal pain lasting more than 3 months. electrotherapy is a non-pharmacologic, non-invasive and simple method back pain treatment that is mainly applied using interferential (if) therapy. the current study was designed to investigate the effect of if on pain, range of motion, and quality of life in patients with chronic non-specific low back pain. materials and methods: 61 patients suffered from chronic non-specific low back pain (cnlbp) were randomly assigned to if group (n=30) and placebo if (n=31). the entire patient received suggested exercise 3 times per week for 4 weeks. the outcome measures were visual analogue scale (vas), lumbar range of motion (rom) in terms of flexion\& extension and the short form-36 (sf-36) health questionnaire to evaluate the quality of life (qol).

participants the study was conducted in outpatient clinics in cairo university hospitals. 60 patients (29 males and 31 females) were invited to participate in the current study. subjects were included in the study if they had lbp of at least three months duration and aged between 25 and 60 years. patients with spinal pathology (tumor, nerve root, fracture, and compromise), cardiopulmonary conditions, pregnancy, and received physiotherapy in the last eight weeks or any contraindications to the use of electrotherapy were excluded.

Eligibility criteria:
inclusion criteria: \*subjects were included in the study if they had lbp of at least three months duration \* age between 25 and 60 years. exclusion criteria: * patients with spinal pathology (tumor, nerve root, fracture, and compromise), * cardiopulmonary conditions * pregnancy, * received physiotherapy in the last eight weeks * any contraindications to the use of electrotherapy were excluded.

Keywords: low back pain, interferential therapy quality of life
pulse analysis for cholecystitis patients before and after cholecystectomy

Conditions: Cholecystitis; Cholecystectomy

Summary: the aim of this study is to record the radial pressure pulse(rpp) of the patients with cholecystitis compared preoperative and postoperative pulse changes in an attempt to determine the relationship between cholecystitis and pulse.

a total of 20 patients were recruited according to the inclusion and exclusion criteria. the patients, aged 32-76 years, were given a diagnosis of cholecystitis by a general surgeon from taiwan's taichung tzu chi hospital. all eligible patients included in the study agreed to participated and signed the informed consent form and the study procedures were approved by the ethical committee of taichung tzu chi general hospital (rec110-12). by measuring and recording the rpp preoperatively and postoperatively, the mean values of the spectral energy (se0-10 hz, se10-50 hz, and se13-50 hz) were obtained for comparison with the preoperative white blood cell (wbc) count.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed with acute or chronic cholecystitis 2. patient hospitalized for cholecystectomy 3. patients who were voluntarily involved in this study exclusion criteria: 1. patients who could not cooperate with pulse diagnosis 2. patients with underlying systemic diseases such as cancer, chronic obstructive pulmonary disease, cardiac failure, chronic renal failure, cirrhosis, etc.

Keywords: radial pressure pulse (rpp)
evaluating off-label use of direct oral anticoagulants (doacs) in hypercoagulable states

Conditions: Hypercoagulable States

Summary: retrospective, cohort study chart review in patients with hypercoagulable states.

* retrospective, cohort study chart review in patients at methodist health system * data will be pulled on all patients with hypercoagulable states identified by icd-9/icd-10 codes from january 1st, 2015 to december 31st, 2019

Eligibility criteria:
inclusion criteria: * patients ≥ 18 year-old * patients with diagnosis of hypercoagulable state identified by icd-9/icd-10 codes * patients who were prescribed doacs or vka for primary or secondary prevention of thrombosis exclusion criteria: * patients with fda-approved indications of oral anticoagulants including atrial fibrillation or treatment/prevention of thrombotic events unrelated to specified hypercoagulable states * patients with incomplete electronic medical records
the role of cyp2c19 on the eradication of h. pylori infection:implication of pk/pd relationships

Conditions: Peptic Ulcer With H. Pylori Infection; Gastritis With H. Pylori Infection

Summary: the objective of this trial is to find the rationale and the optimal dose and duration of regimen for the eradication of h. pylori infection using different proton pump inhibitors.

helicobacter pylori in known to be closely associated with the pathogenesis of gastroduodenal disorders such as peptide ulcer. eradication of this bacterium is important in the treatment of these diseases as well as in the reduction of the recurrence. the one-week triple therapy with proton pump inhibitors (ppis) is now considered to be the standard therapies in the treatment of helicobacter pylori infection, providing more than 80% eradication rates with few adverse effects. ppis are mainly metabolized by cyp2c19, which is known to exhibit polymorphisms in both its genotype and phenotype. based on the pk/pd results of our study on ppi, recently, we have proposed that cyp2c19 poor metabolizers might be subject to advantageous conditions, especially after day-4, for the treatment of h. pylori infection when 20 mg rabeprazole was given twice daily. our results also suggest a possibility to start the triple therapy on day-4 of rabeprazole treatment to ensure the optimal acid suppression effect for antibiotics to exert the bacteriocidal effect. to find the rationale and the optimal dosing regimen for the eradication of h. pylori infection using different proton pump inhibitors, volunteers of four groups would be included in this study. ppi (rabeprazole or esomeprazole) is given for 7 days. antibiotics are given starting from day-1 or day-4 of ppi dosing. the eradication rate of h. pylori infection and the pk/pd of ppis are also evaluated.

Eligibility criteria:
inclusion criteria: * male and female dyspeptic patients with h. pylori-positive peptic ulcer or gastritis will be recruited at the university hospital in this study. exclusion criteria: * 1)pregnant or lactating female;\*2)patients have endoscopy-based evidence of gastric malignancy, pyloric obstruction, and esophageal stricture requiring dilation, fresh clot, active bleeding, or perforated ulcers;3)patients requiring anticoagulants or corticosteroid therapy (at dosages greater than the equivalent of prednisone, 10 mg/day);4)patients with significant impairment of renal function (creatinine\>2mg/dl); liver function impairment (ast and alt 2x upper limit of normal); severe cardiac disease, e.g. angina pectoris, myocardial infarction, cardiac arrhythmia, congestive heart failure (new york heart association functional classification iii and iv) or acute respiratory disease;5)patients with a history of esophageal and/or gastric varices;6)use of other investigational drugs within 30 days prior to the study.

Keywords: rabeprazole, omeprazole, cyp2c19, h. pylori, pk/pd
effects of post isometric relaxation and post facilitation stretching on rom, pain and functional limitations

Conditions: Erector Spinae Tightness

Summary: study design: randomized controlled trial treatment techniques: post isometric relaxation and post facilitation stretching technique sample size: 35 in each group single blinded before giving either treatment to each group, baseline data will be collected from each participant and then after 4th week of treatment.

to compare the effects of post isometric relaxation and post facilitation stretching on rom, pain and functional disability in patients with erector spinae tightness.study setting: bahria international hospital, lahore data will be analyzed using spss version 26.the quantitative variables like range of motion will be presented in the form of mean ±sd and qualitative variables like pain and functional disability will be presented in the form of frequency and percentage.

Eligibility criteria:
inclusion criteria: * • pain in lower back for atleast 4 weeks but less than 1 year. * pain relieved by rest. * decreased flexion, extension and lateral flexion of lumbar spine. * individuals having no signs of nerve root irritation (dermatomal pain and paresthesia) and nerve root compression (dermatomal sensory loss, myotomal weakness, loss of reflex) * age group: 30 - 45 years * both male and female exclusion criteria: * individuals having other lumbar pathologies like disc problems, ligamentous strains, sciatica etc * individuals having any inflammation and malignancy. * pregnancy * individuals having recent trauma, fracture, or surgery
use of oxygen nebulizer for preventing post-operative sore throat

Conditions: Pain, Postoperative

Summary: rationale: delivery dry gas during anesthesia is associated with post-operative sore throat (post). oxygen nebulizer therapy increases humidity to the airway, especially post-extubation. objective: to investigate the effect and complications of oxygen nebulizer therapy on post.


Eligibility criteria:
inclusion criteria: * age 18-75 years * pre-operative hb \>10 g% or hct \> 30% * american society of anesthesiologist (asa) class i-iii * elective surgery * general anesthesia with oroendotracheal tube using macintosh laryngoscope * not exposed to intraoperative nitrous oxide * oxygen saturation at room air \> 95% before induction and at arrival the pacu exclusion criteria: * cases needing icu admission immediately post-operative * conditioning requiring post-operative oxygen therapy e.g. heart disease, pregnancy, morbid obesity, cardiac and thoracic surgery * patients' conditioning affecting to complication of nebulizer oxygen therapy e.g. pulmonary disease, bleomycin treatment * patient's conditioning affecting post assessment e.g. pre-operative using ventilator, recent upper respiratory tract infection (uri), recent lower respiratory tract infection and history of difficult airway * surgical conditioning affecting post e.g. airway surgery, oral surgery, esophageal and neck surgery

Keywords: nebulizer oxygen post-operative sore throat
swedish antibiotic nursing home trial

Conditions: Infections; Urinary Tract Infections

Summary: main aim and objective the aim was to present the treatment of infectious diseases in elderly, especially in nursing homes and further to evaluate the effect of an intervention package aiming at improving treatment with antibiotics in swedish nursing homes specific objectives * present the treatment patterns regarding infectious diseases, including gender aspects in elderly, especially in nursing homes. * through focus group discussions elucidate the decision making process in nursing homes and target the intervention. * based on the above information develop an educational intervention to contribute to the improvement of the prescribing of antibiotics in nursing homes * evaluate the effect of the intervention on quality of prescribing, knowledge and attitudes in relation to available guidelines


Eligibility criteria:
inclusion criteria: * nursing homes where residents have a common dining room and staff, and a self-assessed stable staff situation exclusion criteria: * specialised nursing homes or wards (e.g. oncology wards)

Keywords: infections in nursing homes especially urinary tract infections
effect of osteopathic manipulative treatment on pain in preterms

Conditions: Prematurity

Summary: osteopathic manipulative treatment (omt) has been used to treat term and preterm newborns. recent studies demonstrated the effectiveness of omt in reducing length of stay and costs (cerritelli, 2013) as well as the likelihood of gastrointestinal episodes (pizzolorusso 2011). moreover it was reported the absence of adverse events and side effects considering the approach safe (cerritelli 2013, 2014). omt was extensively used to treat, prevent and manage pain symptoms. numerous research was published addressing acute and chronic pain in different medical conditions. however, no trials were carried out on pain in newborns. the aim of the present clinical trial is to explore the effectiveness of omt in reducing pain in a sample of preterm infants.


Eligibility criteria:
inclusion criteria: * preterm infants * written informed consent by parents or legal guardians * preterms born in the same hospital exclusion criteria: * gestational age \> 37 weeks * genetic disorders * congenital disorders * cardiovascular abnormalities * proven or suspected necrotized enterocolitis with or without gastrointestinal perforation * proven or suspected abdominal obstruction * pre/post surgery patients * pneumoperitoneum * atelectasis * newborn from an hiv seropositive/drug addicted mother * respiratory disorders * transferred to/from other hospital * admitted for preterminal comfort care (defined as neither intubation nor cardio-respiratory resuscitation)

Keywords: prematurity newborns pain cost
antibiotic combination for h. pylori eradication in penicillin-allergic patients

Conditions: Helicobacter Pylori Infection

Summary: this randomized controlled clinical trial will compare the eradication efficacy of bismuth quadruple therapy containing clarithromycin+metronidazole, clarithromycin+levofloxacin, or metronidazole+levofloxacin for helicobacter pylori first-line treatment in penicillin-allergic patients. the completion of this trial will expand new therapy for the treatment of helicobacter pylori, which can not only ensure clinical efficacy, but also reduce the use of antibiotics.


Eligibility criteria:
inclusion criteria: * participate in the trial voluntarily, fully understand the trial, and sign the informed consent form (icf). * 18-75 years old on the day of signing the icf. * helicobacter pylori infection confirmed by 13c-urea breath test or rapid urease test. * have not received helicobacter pylori eradication treatment before. * allergic to penicillin. exclusion criteria: * have received hp eradication treatment. * patients with severe heart, lung, kidney, liver, blood, nerve, endocrine, and psychiatric diseases. * subjects or guardians refused to participate in the trial. * alcohol and/or drugs abuse (addiction or dependence) or poor compliance with doctor's judgment. * have taken antibiotics, bismuth, proton pump inhibitors or chinese traditional medicine 4 weeks before treatment. * pregnant or lactating women. * active peptic ulcer. * allergic to drugs used in the trial. * any other circumstances that are not suitable for recruitment.
pre-operative hormonal treatment for hormone receptor positive breast cancer

Conditions: Breast Cancer

Summary: to investigate prospectively whether short term endocrine treatment can induce molecular changes, predictive for therapy response.

we will perform a randomized, open-label, single-institution study. it will compare the efficacy of three different endocrine treatment regimens (anastrozole +/- fulvestrant or tamoxifen) in changing proliferation-index and inducing apoptosis during a 2-6 week pre-operative treatment period in breast cancer patients. these results will be correlated to gene expression profiles, phosphorylation status of the er, snps in cyp450 sequences, tamoxifen metabolite concentrations, changes in estrogen serum levels and protein expression patterns.

Eligibility criteria:
inclusion criteria: * patients with proven invasive adenocarcinoma of the breast * any tumor with a size ≥ 1cm (not inflammatory breast cancer) * who-performance score 0 or 1 * written informed consent exclusion criteria: * clues of metastatic disease by clinical examination according to most recent nabon guidelines * multicentric breast cancer * inflammatory breast cancer * hormone replacement during the last 12 months * other systemic treatment during the waiting time till surgery * already planned date for surgery within the next 2 weeks * any psychological, familial, sociological or geographical condition potentially hampering adequate informed consent or compliance with the study protocol * patient's refusal to undergo a core biopsy procedure of the primary tumor before the start of treatment nb: a concomitant malignancy within the last five years is not an exclusion criterium, because survival is not the primary endpoint. just as prior invasive breast cancer or dcis within the last 15 years is not an exclusion criterium. nb: patients of childbearing potential must implement adequate non-hormonal contraceptive measures during the study.

Keywords: pre-operative endocrine treatment drug resistance
investigation of individuals with stroke within the icf framework

Conditions: Stroke

Summary: the present study examined stroke patients who applied to occupational therapy units within the framework of icf, following the rehabilitation process, and defining frequently used measurements in terms of icf codes

the international classification of functioning (icf) is a standardized method frequently used by health professionals. this follow-up study was performed in accordance with the declaration of helsinki. the present study examined stroke patients who applied to occupational therapy units within the framework of icf, following the rehabilitation process, and defining frequently used measurements in terms of icf codes. participants were recruited from the patients who applied to the occupational therapy clinic of etlik city hospital. participants who agreed to participate in the study signed an informed consent form. first, the scales were defined within the framework of icf. individuals who had a stroke and were hospitalized in the physiotherapy and rehabilitation clinic of etlik city hospital and included in the study were evaluated using icf parameters within the first 3 days of their hospitalization. all individuals were given a holistic rehabilitation program. individuals who received inpatient treatment and stayed in the hospital for one month were re-evaluated. other individuals who were not included in the study benefited from traditional inpatient treatment services. upon evaluating the rehabilitation service within the framework of icf, significant changes were observed in body functions, activity, and participation. it is recommended that icf be used by occupational therapists and other health professionals, that the scales be associated with icf codes, and that holistic rehabilitation services be developed.

Eligibility criteria:
inclusion criteria: * diagnosis of stroke, age between 18 and 64 years, * being served by hospital, being enrolled in the occupational therapy, * volunteering to participate in the study exclusion criteria: * individuals with orthopedic, psychological or neurological conditions other than stroke that could affect their functioning and those with moderate or severe aphasia were not included in the study

Keywords: stroke activities of daily living participation rehabilitation