Kornimate/medical-research-clean huggingface dataset:
effects of virtual reality in tka patients

Conditions: Knee Arthropathy

Summary: the goal of this clinical trial\] is to investigate the effects of virtual reality (vr) in patients undergoing total knee arthroplasty (tka). the main questions it aims to answer are: * does vr have effects on pain, kinesiophobia, and function during the early rehabilitation period of patients who have undergone tka * does vr contribute to the success of exercise treatment after tka all the patients included in the study were informed about the disease, the goals of post-surgical rehabilitation, the conditions to be considered after tka and exercises. sitting on the side of the bed and mobilization in or out of the room with a walker were provided with the postoperative 1st day exercises. the patients were discharged 2.5 days after surgery. the patients in both groups were taught an exercise program for home practice. in addition to the exercise program, the virtual reality application was applied before the exercises to the vr group. the second evaluation was made 3 days after the end of the treatment in both patient groups. researchers compared vr and exercise to see if pain, kinesiophobia, pain catastrophizing, knee range of motion, function, and quality of life had changed.


Eligibility criteria:
inclusion criteria: * being between the ages of 50 and 70 * being female * having received tka due to being at stage iii or iv according to the kellgren-lawrence osteoarthritis classification * having sufficient eyesight * having kinesiophobia and pain catastrophizing exclusion criteria: * having undergone bilateral knee arthroplasty/revision knee arthroplasty * vertigo or motion-sensitive nausea * being diagnosed with an additional neurological, rheumatological, or oncological disease * having a mini mental test score of less than 24 * being diagnosed with severe anxiety by a specialist physician * inability to complete the treatment program

Keywords: knee arthroplasty vr exercise pain kinesiophobia catastrophization function
effect of dpp-iv inhibitor on glycemic control and autonomic neuropathy in adult patients with diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: rocca et al. reported first that the secretion of incretins, particular glp-1 in rat is regulated by the enteric nervous system, the afferent and efferent vagus nerves \[1\]. further, kazakos et al. \[2\] reported that autonomic nerve disturbance (and) in patients with t2dm impaired the incretin effect owing to decreased glp-1 secretion. however, toft-nielsen et al. \[3\] reported that the decreased glp-1 responses in the patients with type 2 diabetes mellitus (t2dm) are unlikely to be related to the and and, thus, did not support the results of rocca et al. and kazakos et al. recently, yabe at al. \[4\] also observed the same observations in japanese patients with t2dm. meanwhile, jin et al. reported that administration of dpp-iv inhibitor recovered the disturbance of diabetic nerve dysfunction in rat \[5\]. however, it is unknown whether the administration of dpp-iv inhibitor effects on the and in human, although many studies are performed to investigate the effect of the dpp-iv inhibitors on glycemic control. accordingly, it is significant to reinvestigate an effect of dpp-iv inhibitor on glycemic control and autonomic neuropathy in diabetic patients.

autonomic nerve disturbance (and) is estimated to use coefficient of variance of electrocardiographic beat-to-beat intervals (c.v. r-r). maximal change of the c,v. r-r with from usual breathing to deep breathing at the resting was used for the evaluation of and. less than 2.0 % of the maximal value is estimated to have a positive to and. glycemic control is estimated to measure change of hba1c value once three months per year.

Eligibility criteria:
inclusion criteria: type 1 and 2 diabetes mellitus patients * patients who have and determined by c.v. r-r. * outpatients regularly visiting hospital * patients 20 years old (gender is disregarded) exclusion criteria: patients with a serious complication in the heart, liver or kidney * pregnant or possibly pregnant patients, or lactating patients * patients complicated with a malignant tumor at present. * patients participating in other clinical study. * other than the above, patients judged inappropriate as the subjects of this study by the investigator
gross examinations versus frozen section for assessment of surgical margins in oral cancers

Conditions: Oral Cavity Cancer

Summary: surgical margin is a significant prognostic factor in oral cavity squamous cell carcinoma (ocscc)\[1,2,3\]. intra-operative frozen section (fs) has been routinely used by the surgeons to achieve adequate surgical margins. however published literature has failed to show a conclusive benefit of fs in improving oncological outcomes(4-7). the overall identification rate of the inadequate margins by fs is variable with figures in the literature ranging from25-34%.(8-10) revision of margins based on fs is widely practiced in centers where facility for fs is available. however this has not shown to significantly improve local control when compared to cases in which fs was not utilized , in a comparative study done at tata memorial hospital(tmh) (5) more-over fs is a costly procedure, and sparsely available in resource- poor countries. in a recently conducted retrospective study of 1237 patients conducted at tmh, the cost benefit ratio of fs for assessment of margin is as low as 12:1(11). in another prospective study performed at the same center , investigators found that gross examination (ge) of margins by the surgeons was as effective as fs, and achievement of gross 7mm margin all around the tumor obviated the need for fs (12). in a recent meta-analysis of 8 studies that looked at the utility of frozen section and had uniformity in frozen section analysis and definition of close margins, they concluded that revision of margins based on fs does not improve oncological outcomes and further prospective studies are needed to explore this contentious issue (13). with this background, a prospective rct is planned to explore if gross examination by surgeon and subsequent revision of margin (if necessary) is an equally effective alternative to frozen section based revision in a randomized controlled trial.


Eligibility criteria:
inclusion criteria: 1. biopsy proven treatment naïve cases of ocscc who are planned for curative surgery with en-bloc removal of the tumor with adequate margin 2. in detail assessment of the primary tumor is possible pre-operatively 3. written informed consent 4. age more than 18 years exclusion criteria: 1. multifocal disease 2. clinically evident field cancerization 3. previous treatment for oral cavity cancer - surgery /chemo or radiotherapy -

Keywords: oral squamous cell carcinoma frozen section local recurrence
comparison of tofacitinib and methotrexate in the maintained treatment of gpa

Conditions: Granulomatosis With Polyangiitis

Summary: the aim of this study is to identify the optimal maintenance therapy for granulomatosis with polyangiitis (gpa) by comparing the mtx (standard regimen) with tofacitinib in terms of efficacy, i.e. in preventing relapses.

granulomatosis with polyangiitis (gpa), a systemic small-vessel vasculitis, could involve multiple tissues and organs. remission of gpa can be obtained in approximately 80% of the patients with a combination of corticosteroids and cyclophosphamide. however, relapses are frequent and remain a challenge. the optimal drug for maintenance treatment is not determined. tofacitinib is a jak inhibitor which has been proved to be effective in multiple inflammatory diseases such as rheumatoid arthritis. but the efficiency and safety of tofacitinib in treating gpa remains unclear yet. in the present randomized trial, the comparison of mtx (standard regimen) with tofacitinib in terms of efficacy, i.e. in preventing relapses will be conducted.

Eligibility criteria:
inclusion criteria: 1. patients with newly diagnosed or relapsing granulomatosis with polyangiitis met the criteria of 1990 acr and 2012 chapel hill criteria 2. patients in disease flare have achieved remission using a treatment combining corticosteroids and iv cyclophosphamide 3. remission is defined as a birmingham vasculitis activity/ wegener's granulomatosis (bvas/wg) score of 0 and receiving 10 mg/day of oral prednisone (or equivalent) at least 2 weeks 4. age 18 to 75 years 5. written informed consent obtained before taking part in the study exclusion criteria: 1. severe gpa defined as potentially organ- or life-threatening disease (i.e. alveolar haemorrhage, heart failure caused by myocarditis or pericarditis, progressive neurological symptoms, deaf, blindness, et al.) 2. serum creatinine\>120umol/l or proteinuria\>1.0g/d 3. failure to response after treatment with methotrexate or cyclophosphamide previously 4. receipt of a jaki therapy previously 5. co-existence of another systemic autoimmune disease 6. secondary vasculitis (following neoplastic disease, an infection or antithyroid drugs) 7. malignancy or history of malignancy 8. infection by hiv, hcv, hbv or tuberculosis 9. severe uncontrolled cardiovascular, pulmonary, liver, gastrointestinal, endocrine, hematological, neurological, or psychiatric diseases that are not related to systemic vasculitis 10. allergic to any of the medication (cyclophosphamide, corticosteroids, tofacitinib, methotrexate) 11. blood dyscrasias including confirmed: hemoglobin \ 1.5 upper normal limit; estimated glomerular filtration rate\<60ml/min/1.73m2 12. any medical or psychiatric disorder which, in the investigator's opinion, may prevent the administration of treatment and patient follow-up according to the protocol, and/or which may expose the patient to a too greater risk of an adverse effect. 13. incapacity or refusal to understand or sign the informed consent form. 14. pregnancy, breastfeeding.
real-life data of constitutional von willebrand disease in western france

Conditions: Von Willebrand Diseases

Summary: the objective of this observational study hopscotch-will ii is to provide an accurate and detailed account of current von willebrand disease (vwd) therapeutic management by collecting real-life data on hemorrhagic treated events in the 5 western french hemophilia treatment center. the hopscotch-will ii study aims to describe therapeutic management of patients with vwd, following the provision of a recombinant drug in france; it will also permit to carry out a budget impact analysis to quantify the economic significance of this new era.


Eligibility criteria:
inclusion criteria: * constitutional von willebrand disease patient, of any severity, with or without von willebrand factors inhibitors * patient included in the research database berhlingo * patient treated or not by desmopressin or von willebrand factor/fviii/by-passing agents available on the french market (at baseline) * patient who agrees to participate in the hopscotch-will ii and followed in one of the 5 investigator centers exclusion criteria: - patients under guardianship
vessel angles and diameters in stroke disease

Conditions: Stroke Not Otherwise Specified; Control Condition

Summary: retrospective analysis of internal carotid artery morphology on ct angiography images of patients with acute ischemic stroke.


Eligibility criteria:
inclusion criteria: * our study included 66 healthy individuals for control group. the control group consisted of individuals without any pathology or ischemia, selected from patients who underwent brain cta for headache but showed no structural lesions. additionally, none of the control group had a history of stroke or evidence of prior ischemic stroke on mri. exclusion criteria: * after excluding patients with plaques in the carotid arteries (cca and ica), systemic vascular disease, risk factors for cardiogenic stroke, cardioembolism, ischemic stroke due to vasculitis or drug use, and other uncommon causes of stroke, 62 ischemic stroke patients were included in the study.

Keywords: ischemic stroke risk carotid artery bifurcation computed tomography angiography bifurcation angles vessel diameters carotid artery morphology
clinical and genetic testing of patients with usher syndrome

Conditions: Usher Syndrome; Congenital Deafness; Retinitis Pigmentosa

Summary: this study is aimed to characterize russian population of usher patients.

this study is aimed to characterize russian population of usher patients. tasks: stage 1. formation of the primary cohort of patients. patients pre-recruiting will be performed based on deaf-blind support foundation "con-nection" patient database analysis. patients with clinically confirmed usher syndrome will be evaluated according to available data of the clinical examination. stage 2. clinical examination of patients. each patient will undergo the following diagnostic procedures according to the unified protocol: * visometry (with correction and without correction) * ophthalmoscopy * perimetry * optical coherence tomography * electroretinography * visually evoked potentials * refractometry * pneumotonometry * biomicroscopy * tonal audiometry * electronic audiometry (assr test) * acoustic impedance measurement * vestibulometry * electronystagmography * any additional examinations and consultations if necessary medical record will be developed and maintained for each patient consisting results of extended clinical examination. stage 3. genetic study of patients. all enrolled patients will undergo single 4 ml peripheral venous blood sampling. dna will be extracted from leucocytes. dna samples will be analyzed and placed for long-term storage in liquid nitrogen. statistical and bioinformatic analysis of detected genetic mutations in the study cohort will be performed.

Eligibility criteria:
inclusion criteria: * patient fulfill the clinical characteristics for usher syndrome type i, ii or iii as defined by the usher syndrome consortium * according to the results of audiometry, hearing loss is moderate or severe (level of acoustic threshold of audibility is 41 decibel and higher). * results of perimetry for each eye show narrowing for 15 degrees or more. * patient is familiar with participant information sheet * patient signed informed consent form non-inclusion criteria: * participation in other clinical trials (or administration of investigational drugs) during 3 months prior inclusion * any conditions limiting compliance (dementia, neuropsychiatric disease, drug and alcohol abuse etc.) * medical history of traumatic injury of eyes, barotrauma, concussion, craniocerebral trauma, cerebrovascular accident exclusion criteria: * patient's refusal from the further participation in the trial * decompensated diabetes mellitus * severe coronary artery disease * chronic infectious disease * patients with malignant tumors including postoperative period, patients receiving chemotherapy and/or radiotherapy
calcium, probiotics and acute diarrheal disease among indonesian children

Conditions: Healthy; Diarrhea

Summary: this is a long term study on the efficacy of dietary calcium with or without probiotic strains in reducing the mean number of episodes and duration of diarrheal disease.


Eligibility criteria:
inclusion criteria: * apparently healthy children aged 1-6 years, with emphasize on aged 2-5 years, living permanently in low socio-economic urban areas of east jakarta for at least 6 months * parents are willing to sign the informed consent and give the supplements to the children for the period of 6 months * capable and willing to drink liquid milk with a straw (acceptance to be tested at screening by providing a sample drink and placebo straw to be consumed under supervision for 2 days) exclusion criteria: * calcium intake exceeding 75% of the rda for calcium (\<375 mg/d) based on a food frequency questionnaire * currently breastfed children * siblings of already included children that are living in the same household, except if it is a twin sibling * severely malnourished with or without oedema (weight for height-whz z-score of \<-3.00 sd) * symptoms of chronic/congenital diseases and disabilities, suspected tuberculosis by clinical examination, and /or history of allergic disease. * taking (any) antibiotics during 2 weeks prior to start of the study (children will be included after 3 weeks of last antibiotic intake * participation in another clinical trial at the same time or 2 months prior to the start of this study * both mothers and other caregivers present in the family are illiterate

Keywords: calcium probiotics diarrhea children indonesia healthy children acute diarrhea
differences in postprandial glucose changes

Conditions: Diabetes Mellitus, Type II; Overweight or Obesity

Summary: following a meal, in nondiabetic individuals, blood glucose rises to peak at 1hr and returns to baseline in 2 - 3 hours. in t2dm, this peak is higher and prolonged. meal plans for persons with t2dm should comprise evenly spaced, complex carbohydrate portions in order to avoid post-prandial glucose spikes. researchers have developed an expanded line of caribbean-flavoured, low-calorie meal-replacement shakes which have been formulated to match the macronutrient and caloric content of a commercially available brand. in this trial investigators aim to (1) examine the change in glucose levels post intake of caribbean vs the commercially available brand and (2) to conduct a comparative sensory analysis of the two shakes.


Eligibility criteria:
inclusion criteria: 1. a diagnosis of t2dm for any length of time, 2. last hba1c (within the last 6 months) of \< / = 8% exclusion criteria: 1. on insulin for any length of time
epidural nalbuphine for postcesarean epidural morphine induced pruritus

Conditions: Cesarean Section

Summary: can epidural nalbuphine reduce incidence or severity of epidural morphine induced pruritus in patient undergoing cesarean section?

182 parturients,asa 1-2 undergoing cesarean section under epidural block were enrolled in the study. after obtaining informed consent,all received epidural anesthesia using 2% lidocaine with epinephrine 1:200000 via epidural cathetes at l2-3 or l3-4 in a volume suffient to achieve a t4 sensory level bilaterally. after the umbilical cord was clamped,patients were assigned randomly to three groups.the placebo group,n-5 group,and n-10 group received 4 ml epidural solution containing morphine 4 mg plus either saline, nalbuphine 5 mg, and nalbuphine 10 mg respectively.at the post anesthetic care unit, intravenous pethidine pca were administered for inadequate pain control. outcome measures : incidence and severity of postoperative pruritus quality of pain control side effects of epidural morphine and nalbuphine such as respiratory depression,sedation

Eligibility criteria:
inclusion criteria: * full term parturient undergoing elective cesarean section * asa 1-2 exclusion criteria: * drug or alcohol abuses * contraindication for regional anesthesia * received opioids within 12 hours

Keywords: pruritus epidural morphine
child discomfort and parental acceptability of silver diamine fluoride and alternative restorative treatment

Conditions: Dental Caries; Child Discomfort

Summary: the aim of the current study was to compare pain perception of young children treated with sdf and art, as well as their parents' acceptability of both modalities.

eighty, 3-8-years-old children, having at least one deciduous asymptomatic tooth with active caries were randomly assigned into 2 groups; sdf for caries arresting in the test group, and art for caries removal in the control group.

Eligibility criteria:
inclusion criteria: * negative and definitely negative behavior according to frankl's behavior rating scale. * having at least one deciduous asymptomatic tooth with active caries, as defined by the international caries detection and assessment system; icdas ii scores 4, 5, 6. exclusion criteria: * children who suffered from silver allergy, oral ulcerations, pulpal infections and whose parents needed immediate permanent restorations.
evaluation of the effect in platelet count of atorvastatin and n-acetyl cysteine

Conditions: Primary Immune Thrombocytopenia

Summary: the purpose of this study is to assess the ability of atorvastatin and n-acetyl cysteine to elevate the blood (serum) platelet count in patients with immune thrombocytopenia as a mean of a new treatment.

evaluate the efficacy in the elevation of platelet count of the combination of atorvastatin and n-acetyl cysteine in patients with immune thrombocytopenia resistant to steroid therapy or with relapse after treatment, a prospective, proof of concept clinical trial.

Eligibility criteria:
inclusion criteria: * patients that give their informed consent before the procedures of study * thrombocytopenia before intervention (\<100 x10\^9 /l) * patients of either biological sex older than 15 years old * patients with previous diagnosis of primary immune thrombocytopenia that not reach complete remission after treatment (steroid based) or that have a relapse * if the patient is taking steroid based treatment, the dose need to be stable before intervention. exclusion criteria: * patients with secondary immune thrombocytopenia * pregnant patients * patients with hypersensitivity to study treatments * patients that are taking anticoagulant medication or any drug that have an effect on platelet count * hepatic alteration consisting in serum levels of aspartate aminotransferase (ast) and alanine aminotransferase (alt) 3 times above superior laboratory reference limit. * elevation of serum levels of creatinine or bilirubins above 1.5 mg/dl * any cancer diagnosis * coronary heart disease, congestive heart failure, uncontrolled hypertension or arrhythmias. * previous autoimmune disease diagnosis including: systemic lupus erythematosus, rheumatoid arthritis or systemic sclerosis.

Keywords: immune thrombocytopenia atorvastatin n-acetylcysteine steroids
cold saline irrigation before endobronchial biopsy

Conditions: Lung Diseases

Summary: patients undergoing an endobronchial ultrasound and biopsy can experience bleeding during the biopsy. these biopsies are read in real time by pathologists who travel to the endoscopy unit during the procedure. often, when this happens, the blood contaminates the pathology slides making the slide unreadable. this then requires more biopsies to be performed, thus prolonging the procedure, and increasing anesthesia time. one innovative way to reduce bleeding may be to irrigate the bronchial wall with cold saline, where the biopsy is to be taken, immediately before biopsy, thus causing vasoconstriction and possibly resulting in less blood contamination on the biopsy slides. the current study will evaluate this prophylactic irrigation with saline to control bleeding, thus resulting in a quicker diagnostic result of the biopsies.


Eligibility criteria:
inclusion criteria: * undergoing an endobronchial ultrasound and biopsy at bethesda north hospital exclusion criteria: * under 18 years old * does not speak english * unable to consent to involvement in the research study * is pregnant * has a bleeding disorder/diagnosis * currently taking anticoagulant medications and not stopped for procedure * documented low platelets (\<100,000) * had a biopsy taken immediately prior to the endobronchial ultrasound

Keywords: biopsy