Kornimate/medical-research-clean huggingface dataset:
the effect of thyme and sumac on the thermic effect of food and comparison between warm and cold temperament people

Conditions: Effects of; Food, Allergic

Summary: the purpose of this study is to determine the effect of zataria multiflora boiss and sumac on the thermic effect of food, activity of sympathetic - parasympathetic system: comparison between warm and cold temperament people.

human body needs to energy in order to preserve life.there are three forms of energy consumption at body, consumption at baseline or resting, consumption at energy expenditure for thermic effect of food and energy is spent in physical activity.also from the perspective of traditional medicine, cold and warm natured people are determined based on certain mental and physical protests. there are different temperament not only in traditional iranian medicine, but in traditional chinese medicine, indian, greek, arabic, romanian, and there are european.as various factors on the basal metabolism and thermic effect of food , also are several factors such as age, sex, physical condition of the environment that have an impact on individual temperament. since the protests seem warm and cool temperament and factors affecting on their basal metabolic rate and thermogenesis so that food may explain the relationship between warm and cold temperament to mind is the basal metabolism; it seems those are hot temperament, their basal metabolic rate is higher bmr than normal and those who are cold temperament, have a lower bmr. on the other hand seems that thermic effect of food in people who have hot temperament is higher than thermic effect of food in people who have cold temperament. so that we need to use of two nutrient foods, in this way we consided the multiple criteria and then were selected sumac and thyme. on the other hand, in order to study possible mechanisms affecting basal metabolism, thermogenesis of food, according to previous studies and also matches that there are between sympathetic - parasympathetic and thyroid function, with symptoms of cold and warm temperament there, checking of activity of these organs seems necessary. because to maintain basal metabolic rate is essential for human life, so that each factor in order to better understand these is helpful to human life.and the need for such study makes clear;through this step help toward improving public health

Eligibility criteria:
inclusion criteria: * age 18 to 40 years * having to suffer any ill health and lack of attention to history and physical examination * willing to cooperate with the project exclusion criteria: * catching any disease. * use of specific dietary patterns such as vegetarianism * having a bmi outside the normal range * use of any drugs or supplements in past month * allergic reaction to food allergy and non-prescription * an unwillingness to cooperate in any of the stages of implementation

Keywords: zataria multiflora boiss sumac tef temperament
absorption of heme and non-heme iron in pregnant and non-pregnant women and mechanisms of fetal iron transfer

Conditions: Iron Deficiency

Summary: the three specific aims of this study are 1) to assess the impact of iron status on relative differences in absorption of heme and non-heme iron among pregnant women and non-pregnant women, 2) to assess the magnitude and the determinants of heme and non-heme iron transfer to the fetus over the last trimester of pregnancy, and 3) to characterize relationships between placental iron binding proteins with the enrichment of stable iron isotopes in the neonate at birth. the investigators hypothesize that there will be up regulation of heme and non-heme iron absorption and up regulation of placental iron transport proteins in response to low maternal iron stores.

to measure the absorption of heme and non-heme iron in women, pregnant and non-pregnant women will consume a standardized meal of pork (intrinsically labeled with 58fe) and a second meal of non-heme 57fe (as ferrous sulfate). two weeks after ingesting these test meals, a blood sample will be collected from each women and the amount of heme (58fe) and non-heme (57fe) iron incorporated into red blood cells will be measured with magnetic sector thermal ionization mass spectrometry. cord blood samples and placental tissue will be obtained at delivery to measure how these two forms of dietary iron were transferred across the placenta to the fetus. maternal and neonatal iron status and placental proteins involved in iron transport will also be measured. data from this study will provide information that aims to improve human health by better understanding the iron requirements of a population at high risk of iron deficiency.

Eligibility criteria:
inclusion criteria: * pregnant subjects (15-35 yrs): non-smoking,healthy with uncomplicated pregnancies at time of enrollment * non-pregnant subjects (18-35 yrs): healthy, non-smoking, not taking vitamin or mineral supplements and not planning on becoming pregnant during course of study. exclusion criteria: * pregnant subjects: gestational diabetes, hypertension, preeclampsia, underlying malabsorption diseases or other diagnosed medical problems known to impact iron homeostasis * non-pregnant subjects: underlying malabsorption diseases or other diagnosed medical problems known to impact iron homeostasis.

Keywords: iron pregnancy heme iron non-heme iron stable isotopes women/adolescents
comprehensive geriatric assessment in kidney transplantation

Conditions: Kidney Transplant; Complications; Frailty Syndrome; Depressive Syndrome

Summary: this observational study aims to analyze the results of comprehensive geriatric assessment and to monitor the development of functional status in geriatric kidney transplant candidates and recipients.

kidney transplantation represents the best therapeutical option in patients in end stage kidney disease. at present, increasing number of older patients are referred for kidney transplantation. patients' functional status has been shown to be associated with transplant outcomes. the comprehensive geriatric assessment (cga) of functional and mental status in older kidney transplant candidates might play an important and supportive role in the pre-transplant evaluation process, including acceptance for transplantation. in kidney transplant recipients, this examination might be useful to evaluate the impact of pre-transplant status on post-transplant course. also in ktr, cga may contribute to the improvement of functional status and quality of life independently from the graft function.

Eligibility criteria:
inclusion criteria: * kidney transplant candidates aged 60+ years * kidney transplant recipients aged 60+ years exclusion criteria: * kidney transplant candidates aged below 60 years * kidney transplant recipients aged below 60 years

Keywords: kidney transplantation geriatric frailty depression pretransplant evaluation comprehensive geriatric assessment posttransplant
neurophysiological attention test (nat) for objective assessment of attention deficit hyperactivity disorder (adhd)

Conditions: Attention Deficit Hyperactivity Disorder (ADHD)

Summary: the purpose of this study is develop a new assessment tool for attention deficit-hyperactivity disorder (adhd) and to then test its validity (i.e. ability to discriminate between individuals with adhd and healthy controls).

the purpose of this study is to develop a novel approach and software for analyzing electroencephalography (eeg) data to identify biomarkers of adhd. then to test the ability of this assessment tool to differentiate between adults with adhd and healthy controls by comparing the classification accuracy of the metrics from the new tool to the classification accuracy of existing behavioral tests for adhd.

Eligibility criteria:
inclusion criteria: * specific inclusion criteria for adhd are: 1. meet established dsm-5 criteria for adhd predominately inattentive or combined subtype with clinically significant levels of impairment, diagnosed by structured clinical interview, the mini international neuropsychiatric interview, and corroborating information 2. clinical global impression-severity (cgi-s) score ≥ 4 for adhd 3. no lifetime history of dsm-5 bipolar disorder, psychotic disorder, pervasive developmental disorder, obsessive-compulsive disorder, substance abuse, or substance dependence (except nicotine) as assessed wit the mini 4. able in the opinion of the investigator to complete all required study procedures. exclusion criteria: * exclusion criteria for both groups are: 1. history of diagnosis of childhood disorder other than adhd (e.g. autism, dyslexia) 2. history of any general medical condition likely to require chronic use of medication with identified cns effects suspected to alter cognitive performance 3. history of seizure disorder, brain tumor, other major neurological disorder or head injury resulting in loss of consciousness 4. serious oxygen deprivation 5. current psychopathology requiring ongoing treatment with antipsychotic medications, mood stabilizers, benzodiazepines, or anticonvulsants 6. current untreated psychopathology which is rated to be primary in terms of severity (greater than adhd severity) 7. current treatment with guanfacine.
assessment of pituitary adenylate cyclase activating polypeptide-brain derived neurotrophic factor (pacap-bdnf) signaling system involvement in etiology and treatment of major depression

Conditions: Major Depression

Summary: the neuropeptide pituitary adenylate cyclase activating polypeptide (pacap) and its receptors pac1 and vpac2 are widely expressed in the nervous system. the investigators found that pacap treatment of neuronal cell cultures increases expression of brain derived neurotrophic factor (bdnf) that plays an important role in the etiology of psychiatric disorders and action of antidepressants. for the first time, the investigators demonstrated that treatment by paroxetine and citalopram significantly decreases pac1 and vpac2 and upregulates pacap mrna expression, whereas imipramine shows an opposite effect. moreover, pacap, pac1 and vpac2 expression is highly correlated with bdnf expression. their in vivo studies show that imipramine reduces bdnf and increases pac1 mrna expression in murine hippocampus, suggesting that antidepressants may affect neuronal plasticity through pacap-bdnf interactions. based on their observations in experimental systems, the investigators hypothesize that pacap signaling system may be involved in the etiology of depression and mechanism of antidepressant action. the investigators will evaluate this hypothesis by examining serum pacap levels, effect of antidepressants on pacap levels, and gene polymorphisms of pacap and its receptors in major depressive disorder patients. this study will enhance the investigators' understanding of pacap's role in the etiology of depression and antidepressant treatment and will provide a basis to evaluate pacap pathway as a potential target for diagnostics and novel antidepressants drug discovery.


Eligibility criteria:
inclusion criteria: 1. men and women 18-65 age old 2. patients with dsm-iv (or/and icd-10) diagnosis mdd 3. volunteers without dsm-iv (or/and icd-10) diagnosis mdd 4. for patients with dsm-iv (or/and icd-10) diagnosis mdd minimum 2 weeks free from benzodiazepines, mood stabilizers and neuroleptics. 5. all patients from mdd group treatment only by ssri antidepressant medications. exclusion criteria: 1. mdd with co-morbidity 2. alcohol and drug use less than 1 month before the study

Keywords: pacap (pituitary adenylate cyclase activating polypeptide) major depression receptors gene polymorphism pacap signaling system etiology of major depression mechanism of antidepressants action pacap receptors gene polymorphism pathogenesis of major depression responsiveness to the antidepressant drugs
effects of power ball on grip strength in children with developmental delay.

Conditions: Developmental Delay

Summary: developmental delay refers to the child who does not perform the normal milestones as other children accomplish in the same age within time or somehow late but can achieve them. while if the delay is found in two or more than two areas of the developmental skill it is known as global developmental delay (gdd). it is divided into mild, moderate and severe developmental delay contributed by many other causes like prenatal, perinatal, postnatal and socioeconomic factors. the objective of the study is to determine the effects of power ball on grip strengthening children with developmental delay. in this study, we will randomly assigned 28 children into two groups, one group will be control group getting the conventional treatment (isometric hand grip training exercises) and other will be experimental group getting the power ball training with conventional treatment. during the sessions hand held dynamometer is use to check the grip strength. by using power ball grip strength in children with developmental delay can be improved.


Eligibility criteria:
inclusion criteria: * age 7-12 years * both genders (male /female) * moderate developmental delay * affected fine motor skill exclusion criteria: * with another neurological conditions(cerebral palsy, down's syndrome, autism) * genetic disorder-

Keywords: power ball strengthening exercises hand grip developmental delay dynamometer
evaluation of the use of machine learning techniques to classify neurodegenerative parkinsonian syndromes (artificial intelligence)

Conditions: DaTSCAN SPECT Scans

Summary: the diagnosis of parkinson's disease (pd) relies mainly on clinical observation of the patient, looking for the three characteristic symptoms and sometimes remains a real challenge. machine learning (ml) algorithms could help to diagnose pd early and differentiate idiopathic pd from atypical parkinsonian syndromes. in this context, the work of castillo-barnes' team provided a set of imaging features based on morphological characteristics extracted from datscan® or ioflupane (iodine-123-labeled radiopharmaceutical) single-photon emission computed tomography (spect) scans to discern healthy participants from participants with parkinson's disease in a balanced set of spects from the "parkinson's progression markers initiative" (ppmi) data base. the team of a study evaluated the classification performance of parkinson's patients and normal controls when semi-quantitative indicators and shape features obtained on the dopamine transporter (dat) by ioflupane (123i-ip) single-photon emission computed tomography (spect) are combined as a machine learning (ml) feature. artificial intelligence (ai) based methods can improve diagnostic assessments. several dopaminergic imaging studies using artificial have reported accuracy of up to 90% for the diagnosis of pd. these automated approaches use machine learning methods, based on textural analyses, to (i) differentiate pd and healthy subjects, (ii) differentiate pd and vascular parkinsonism, and (iii) distinguish between different forms of atypical parkinsonism. a study conducted in 2 centers using a linear support vector machine (svm) model discriminated patients with pd and healthy subjects with an accuracy of 82.5%.this performance is similar to visual assessment by nuclear physicians a linear svm model based on voxel values of statistical parametric images was able to differentiate pd from vascular parkinsonism with an accuracy of 90.4%. the nancy team has extensive experience in the detection of pd in spect and spect/ct scans with ioflupane or datscan™


Eligibility criteria:
inclusion criteria: * patients who performed a datscan spect scan in the nuclear medicine department of the nancy chru between 21/11/2011 and 01/09/2017. * reviews that took place between 11/21/2011 and 9/1/2017 were repatriated from pacs to the processing consoles.
identifying local signs at the catheter insertion site with artificial intelligence

Conditions: Catheter Infection

Summary: deepcath is the first step to the introduction of artificial intelligence in catheter care. a better use of visualisation of catheter exit site should be used not only by the hcws but also by the patients and their family. a deep learning system able to detect visual abnormalities of the catheter exit site will be an helpful tools to develop a continuous follow-up of intravascular catheters.


Eligibility criteria:
inclusion criteria: patients over 18 years of age patients with one or more implanted central venous, midline, piccline, arterial, or peripheral catheters. patient and/or trusted person and/or family who have verbally stated their non-objection to the study patient affiliated or beneficiary of a social security plan exclusion criteria: patients presenting a peripheral identification sign close to the catheter insertion point cannot be masked when the photograph is taken. thus, jewelry, clothing, tattoos, scars, and birthmarks are identifying features. patients whose catheter insertion point is not visible.

Keywords: catheter infection deep learning local signs
abdominal wall nerve blockade: a comparison with local port site injection as well as between the use of ultrasound and laparoscopy to guide placement

Conditions: Postoperative Pain

Summary: the investigators will perform a prospective randomized study to compare the effectiveness of laparoscopic-guided abdominal wall nerve blocks with local wound site infiltration and with ultrasounded guided abdominal wall blocks.

pain control after abdominal surgery in children is often a complex, multifaceted problem that requires a multimodal approach to treatment. infiltration of wounds with long-acting local anesthetic, either into the surgical field or through locoregional nerve blockade, has been known to decrease narcotic requirements. nerve blocks of the abdominal wall can occur through several modalities, among them the transverse abdominis plane block and the rectus sheath block. the transversus abdominis plane (tap) block places local anesthetic in a plane between the internal oblique and transversus abdominis muscles, directly blocking innervation of spinal nerves t9-l3, the ilioinguinal, iliohypogastric and lateral cutaneous branches of l1-3, reducing pain sensation to the anterior abdominal wall. the rectus sheath block places local anesthetic between the internal oblique and transversus abdominis at the level of the terminal branches of intercostal nerves 9-11. the investigators will perform a prospective randomized study to compare the effectiveness of laparoscopic-guided abdominal wall nerve blocks with local wound site infiltration and with ultrasounded guided abdominal wall blocks. the goal of this study is to determine whether patients who receive a nerve block have significantly less pain compared to patients who receive local infiltration of anesthetic. secondly, the investigators believe that laparoscopic-guided abdominal wall nerve blocks should be as effective as abdominal wall blocks performed under ultrasound-guidance, and may in fact allow for more consistent infiltration of local anesthetic to desired nerve bundles. thirdly, the investigators believe that laparoscopic-guided abdominal wall nerve blocks are significantly less time intensive than ultrasound-guided abdominal wall nerve blocks, allowing a cost savings and decreased time under general anesthesia.

Eligibility criteria:
inclusion criteria: 1. patients 5 - 17 years old. 2. patients undergoing laparoscopic procedures 3. patients that weigh greater than or equal to 34 kg and less than 100 kg. exclusion criteria: 1. patients who underwent open surgical procedures will be excluded from this study. 2. patients that weigh less than 34kg. 3. patients that weigh more than 100 kg. 4. perforated appendicitis. 5. bowel obstruction

Keywords: nerve block laparoscopy anesthesia
behavioural study in chronic pain : creativity and motivation, and circuits involved in functional mri

Conditions: Chronic Pain

Summary: being creative means having the ability to produce ideas, actions or works that are original and different from what we have already done. this process involves mental flexibility, in particular the association of distant ideas or divergent thinking. this creative potential is complex and depends on a number of factors, both internal (personality, motivation, emotional state, stress) and external to the individual (socio-cultural context). the generation of creative ideas involves the fronto-striatal circuit, with a balance between flexibility and perseverance. the striatum is central to the reward system and mental flexibility, while the prefrontal cortex is involved in executive control, underpinning perseverance functions. dopamine plays a key role in this balance, and changes in dopamine levels, depending on the type of receptor activated, will have a direct impact on the transition between mental flexibility and perseverance. furthermore, in the context of chronic pain, changes in connectivity and activity can be observed in neuroimaging in these same regions of the reward circuit. this suggests that the dopaminergic system is also involved in the chronicisation of pain. the creative process would therefore be correlated with the dopaminergic reward system, involving several dimensions, both cognitive in terms of mental flexibility, coping strategies and perseverance, and motivational. in this context, art therapy treatments are beginning to be studied, particularly in patients suffering from alzheimer's or parkinson's disease, showing improvements in anxiety and depression. art therapy has not yet been widely proposed or studied for patients suffering from chronic pain. a more detailed behavioural study would confirm and clarify the clinical benefits for patients, by exploring the neuronal circuits involved, particularly the dopaminergic reward system.


Eligibility criteria:
inclusion criteria: * patient aged 18 and over * consent to participate in the study * available for protocol visits * treated for chronic pain exclusion criteria: * progressive neurodegenerative neurological pathology impairing cognitive function * untreated clinical depressive syndrome * fibromyalgia in the foreground * high doses of opioid treatment (greater than 100 mg/d of morphine equivalent) * impaired judgement or inability to receive information that prevents performance of behavioural tasks * absolute contraindication to mri (e.g. pacemaker and implantable stimulator not mri compatible, intra-orbital metallic foreign body); * persons benefiting from a legal protection measure * pregnant or breast-feeding women * patient deprived of liberty * patient suffering from mental disorders