Kornimate/medical-research-clean huggingface dataset:
platelet-rich plasma vs. whole blood for gluteus medius tendinopathy

Conditions: Tendinopathy; Hip Pain

Summary: gluteus medius tendinopathy, which is often referred to as greater trochanteric pain syndrome, is characterized by pain in the lateral aspect of the hip that is aggravated by side lying, stair climbing, and walking. treatment is currently limited to lifestyle modifications, corticosteroid injections, physical therapy, and open and endoscopic surgical repair. platelet rich plasma (prp) injections contain important growth factors that are essential in the healing and tissue formation processes. however, the extent to which prp is more efficacious than whole blood in tendinopathy remains unclear. in this double-blind randomized trial, patients will be allocated to receive either a prp or whole-blood injection. post-procedure assessments will occur at 6 weeks, 3 months, 6 months, 9 months, and 1 year.


Eligibility criteria:
inclusion criteria: * moderate to severe lateral hip pain for greater than 3 months * symptoms are refractory to conservative treatment, including at least 8 weeks of traditional physical therapy for this condition * moderate to severe gluteus medius tendinosis with or without partial tear \<1 cm * normal neurologic exam except for hip abductor weakness on the affected side exclusion criteria: * severe (tonnis grade \>1) hip osteoarthritis with active synovitis or bone edema * active lumbar radiculopathy with pain, numbness or weakness in a dermatomal distribution * no evidence of fatty atrophy, denervation, or complete tears of gluteus medius seen on mri * any condition that requires anti-platelet or anti-coagulation therapy, including aspirin therapy for cardiac conditions * non-english speaking

Keywords: gluteus medius tendinosis
european physician survey of egfr inhibitor prescribing patterns

Conditions: Metastatic Colorectal Cancer

Summary: to ensure the appropriate administration of vectibix for the treatment of mcrc with wild-type kras in real-world practice, it is important to understand the awareness of practicing oncologists regarding the correct indication and appropriate administration of vectibix. it is also critical to monitor changes in oncologists' awareness and practice between the different rounds of the study.

the survey will be conducted for 3 rounds in months 0, 12, and 24 after the first interview. before the beginning of each round, a sampling list will be created by amgen. in each round of the survey, potential participating oncologists will be sampled from each country's sampling list through random sampling and reached through telephone, letter or email. during the initial contact, the oncologists will be assessed for their eligibility to participate in the study by using a standardized screening questionnaire. the initial contact and screening of potential participating oncologists will continue until a total of 150 eligible oncologists agree to participate in each round. the number of oncologists sampled in each country will be proportional to the use of vectibix in each country and the number of oncology physicians estimated to prescribe vectibix. each eligible oncologist can only participate in 1 of the 3 rounds of survey. study staff will then conduct the survey with each of the identified eligible oncologists over the telephone, using a standardized questionnaire. information about their awareness of the correct indication and appropriate administration of vectibix and their experience in the administration of vectibix treatment in the previous 6 months will be collected. we will make every attempt to collect the correct information from participating oncologists. this may require at least two phone calls to allow an oncologist to review their notes in order to report the correct data.

Eligibility criteria:
physician inclusion criteria: * must be a practicing oncology specialist * must treat at least 3 new or continuing patients with metastatic colorectal cancer in the last quarter * must have prescribed vectibix within the last 6 months to metastatic colorectal cancer patients exclusion criteria: * must not have taken part in this study previously * must not have participated in amgen study number 20101120.

Keywords: metastatic colorectal cancer
metals/vitamins levels in ntd

Conditions: Neural Tube Defects

Summary: introduction: heavy metals important pollutants produced from anthropogenic activities, has been suggested to be embryotoxic and fetotoxic in a lot of studies. the aims of this study were to determine the levels of trace elements and heavy metals, namely folic acid, zinc (zn), molybdenum (mo), vanadium (v), strontium (sr), aluminium (al), tin (sn), antimony (sb), mercury (hg), calcium (ca), iron ( fe), magnesium (mg), phosphorus (p), barium (b) and selenium (se), in the amniotic fluid of pregnant women, and to investigate their relationship with neural tube defects (ntds). methods: the study will be included 70 pregnant women whose fetuses were complicated with ntds (study group) and 70 pregnant women with unaffected healthy fetuses (control group). the samples levels of elements and vitamins will be measured using inductively coupled plasma-mass spectrometry and will be compared between the two groups.

detailed description: this observational case-control study will be conducted at the department of obstetrics and gynecology, cengiz gokcek public hospital, gaziantep, turkey, between august 2020 and march 2021. the protocol was approved by the ethics committee for clinical research of gaziantep university (reference no: 2020/167). the study strictly will be adhered to the principles of the declaration of helsinki. all women will be provided written informed consent before the acquisition of all samples. the study will be included 140 pregnant women who underwent amniocentesis at the investigator's perinatology department. the study group will be included 70 pregnant women whose fetuses were found to have congenital ntds (eg, anencephaly, spina bifida, acrania, and encephalocele) on detailed ultrasonographic examinations between 16 and 37 weeks of pregnancy. the control group included pregnant women with healthy fetuses (n = 70), who were matched for gestational weeks and maternal age and underwent amniocentesis because of age-related risk or increased risk in the triple test. then, this study will be determined maternal plasma/urine/hair, and amniotic fluid folic acid, zinc (zn), molybdenum (mo), vanadium (v), strontium (sr), aluminium (al), tin (sn), antimony (sb), mercury (hg), calcium (ca), iron ( fe), magnesium (mg), phosphorus (p), barium (b) and selenium (se) concentrations in women with ntd compared to those of volunteer healthy pregnant women.

Eligibility criteria:
inclusion criteria: * pregnant women complicated with neural tube defects * healthy pregnancy * singleton pregnancy exclusion criteria: 1. pregnant women with any systemic condition (such as chronic hypertension, renal disease and ) 2. women who have dyed their hair in the last 5 months 3. history of using any medication 4. presence of gestational hypertension or gestational diabetes 5. drug user 6. patients who had other fetal congenital abnormalities or genetic syndromes 7. multiple-gestation pregnancies 8. intrauterine fetal death 9. oligohydramnios
pain outcomes following video-assisted thoracic surgery (vats) with lap protector

Conditions: Lung Cancer

Summary: the purpose of this study is to see if different types of spreading (rigid or soft) of video-assisted thoracoscopic surgery (vats) for lung cancer have different effects on pain.

the lap-protector (hakko co., japan) is a device that consists of two flexible rings made of superelasticity alloys covered with polyurethane polyamide, and a thin silicone rubber membrane that is attached to the outer rim of the two rings. if the two rings are pulled apart, the device assumes a cylindrical shape. the outer diameter of each flexible ring is 12 cm, and this device can be used for minilaparotomy wounds between 5 and 9cm long.

Eligibility criteria:
inclusion criteria: * non-small cell lung cancer stage ib - iiia * ecog status 0-1 exclusion criteria: * prior chemotherapy and/or radiation therapy for lung cancer * peripheral neuropathy \> grade 1 * concurrent other malignancies, other than basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix * medical condition that will not permit treatment or follow up according to the protocol * pregnant or nursing women * hiv-positive patients

Keywords: video-assisted thoracoscopic surgery soft spreading lap protector
a continuation trial for subjects with lupus that completed protocol hgs1006-c1056 or hgs1006-c1057

Conditions: Systemic Lupus Erythematosus

Summary: this is a long-term continuation study to provide continuing treatment to subjects with sle.

this trial is a long-term continuation study to provide continuing treatment to subjects with system lupus erythematosus (sle).

Eligibility criteria:
inclusion criteria: * have completed the hgs 1006-c1056 or hgs 1006-c1057 protocol through the week 72 or week 48 visits, respectively. exclusion criteria: * have developed any other medical disease or condition that has made the patient unsuitable for this study in the opinion of their physician.

Keywords: sle belimumab antibodies systemic lupus erythematosus lupus autoimmune diseases
investigating the retardation effect of octa-guided targeted photocoagulation on the progression of non-perfusion areas in diabetic retinopathy patients

Conditions: Diabetic Retinopathy

Summary: this study aims to evaluate the impact of widefield octa-guided selective photocoagulation on the progression of diabetic retinopathy (dr) by comparing the control of non-perfusion (np) areas, dr grading, and management of other dr lesions. the study is designed as a parallel randomized controlled trial. from february 2025 to august 2026, 30 diabetic patients attending the ophthalmology department of sichuan provincial people's hospital will be enrolled. using a simple randomization method, one eye of each patient will be assigned to the intervention group, while the contralateral eye will serve as the control, resulting in 30 eyes in each group. the intervention group will undergo octa-guided selective photocoagulation, specifically using a grid pattern (3x3) of spot laser applied once to the np area, extending one spot diameter beyond the np boundary. each session will last 10-20 minutes. the control group will receive no treatment. the study will compare changes in np area, dr grading progression, and control of other dr lesions at 3, 6, 9, and 12 months between the two groups.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * type 1 or type 2 diabetes mellitus * clinical dilated fundus examination and optos imaging within 7 fields showing diabetic retinopathy (dr) lesions no more severe than severe non-proliferative diabetic retinopathy (npdr) * optical coherence tomography angiography (octa) demonstrating non-perfusion (np) areas greater than 1 disc diameter (pd) in both eyes * diabetic retinopathy in both eyes at the same stage, with the total np area within the observed range of octa being comparable (difference less than 5 pd) * absence of other ocular diseases that could lead to the formation of retinal microaneurysms * absence of other ocular diseases that could lead to the formation of retinal non-perfusion areas * no diabetic macular edema involving the fovea * no history of retinal laser treatment * no history of intravitreal injection therapy within the past 3 months * no history of ocular surgery other than cataract surgery * ability to cooperate with all examinations and provide informed consent exclusion criteria: * optical media opacity affecting octa imaging * patients with difficulties in cooperating with laser treatment * patients with renal failure, diabetic neuropathy, or severe cardiovascular diseases * patients who are unlikely to complete follow-ups every 3 months, as well as those residing in other provinces * patients requiring early prp (conditions include: combined dme, planned cataract surgery, pregnancy planning, early pdr, poor follow-up compliance, severe vision loss in the other eye, poor glycemic control, poor renal function, or type 1 diabetes) * ffa showing np greater than 10 pd within the etdrs area or a total np area greater than 75 pd, or an ischemia index greater than 35%
aerobic exercise on ventilatory efficiency in cad patients

Conditions: Coronary Artery Disease; Exercise Addiction; Complication, Cardio-respiratory

Summary: the purpose of the present study was to test the hypothesis that patients with coronary artery disease with lower aerobic fitness exhibit greater responsiveness on improving ventilatory efficiency after aerobic exercise training.

measurements of ventilatory efficiency during cardiorespiratory exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. in this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs. in addition, a growing body of studies has demonstrated that lower ventilatory efficiency during exercise is considered an important predictor of risk mortality, hospitalization, and other outcomes than peak vo2.

Eligibility criteria:
inclusion criteria: * was stable coronary artery disease diagnosed by coronary angiography exclusion criteria: * unstable angina pectoris, * complex ventricular arrhythmias, * pulmonary congestion and * orthopaedic or neurological limitations to exercise

Keywords: coronary artery disease exercise ventilatory efficiency
using virtual counselors to overcome genetic literacy barriers

Conditions: Heart Disease; Stroke; Diabetes; Cancer

Summary: a relational agent (ra) "virtual counselor" (vicky: virtual counselor for knowing your family history) has been developed to collect family health history information for common health conditions including heart disease, stroke, diabetes, hypertension and various cancers. in this study, the investigators will conduct a randomized controlled trial (rct) to compare the efficacy of using vicky to the existing my family health portrait (mfhp) tool for collecting family health history information among an underserved primary care patient population. the primary aims of the study are to 1) evaluate the efficacy of vicky versus mfhp for collecting accurate family health histories and 2) determine whether accuracy varies as a function of health literacy. this project will obtain validation data on the efficacy of both vicky and mfhp for collecting accurate family history data among an underserved patient population, in two languages (english and spanish). the study will determine whether a virtual counselor can overcome many of the existing barriers to using traditional web-based family history tools.


Eligibility criteria:
inclusion criteria: * 21 years of age or older; * current boston medical center patient - must have an upcoming returning patient appointment at boston medical center or affiliated clinic within 3 months of recruitment; * speaks english and/or spanish. exclusion criteria: * under 21 years of age; * not a current patient of boston medical center or affiliated clinic; * unable to speak english and/or spanish.

Keywords: family health history genetic literacy health literacy relational agent common chronic conditions
a clinical trial for ctd-ild treatment

Conditions: Interstitial Lung Disease; Connective Tissue Disease

Summary: the first objective of this protocol is to assess the tolerability and safety of n-acetylcysteine (nac) in patients with connective tissue disease related interstitial lung disease (ctd-ild).

the investigators will assess tolerability and safety at scheduled intervals via standard of care physical exam findings, monitoring complete blood count, serum chemistry, and pulmonary function tests, along with patient reports of medication intolerance and change in symptoms of dyspnea.

Eligibility criteria:
inclusion: 1. subject gives voluntary written informed consent to participate in the study. 2. subject has been diagnosed with a connective tissue disease and associated interstitial lung disease confirmed by computed tomography of the lungs along with symptoms of cough and/or shortness of breath. 3. males and females age greater than 18 years at time of screening. 4. females of childbearing potential must be willing to use a reliable form of medically acceptable contraception and have a negative pregnancy test confirmed at baseline before starting nac as per standard of care. women who are surgically sterile or have been post-menopausal for at least two years are not considered to be of child-bearing potential. exclusion: 1. history of severe chronic kidney disease defined as a glomerular filtration rate of less than 30. 2. hemoglobin concentration less than 70% of the lower limit of the normal range at time of screening. 3. moderate to severe hepatic impairment, i.e., child-pugh class b or c.

Keywords: interstitial lung disease connective tissue disease scleroderma rheumatoid arthritis sjogren's syndrome mixed connective tissue disease dermatomyositis polymyositis systemic lupus erythematosis
cell phone technology targeting art adherence and drug use

Conditions: HIV; Opioid Abuse

Summary: the objective of the current research is to improve treatment for injection opioid users by augmenting pharmacotherapy with an innovative text-messaging strategy to promote relapse prevention skills, reduce hiv-risk behaviors, and improve hiv treatment regimen adherence.

the specific aims of this research are 1) to develop and refine, with user feedback, a cognitive behavioral therapy-based text-messaging intervention (txt-cbt) for hiv-infected adults with opioid dependence; 2) to conduct a pilot randomized clinical trial to assess the feasibility of recruiting and retaining individuals for a large scale study and to determine the effect size of txt-cbt over and above standard care (sc) on opioid use, hiv medication adherence, and healthcare outcomes. both sc and sc+txt-cbt participants will be assessed at baseline, treatment-end, and 12 weeks post-treatment; and 3) to examine potential mechanisms of action of txt-cbt, including self-efficacy, affect regulation, and social support. the investigators hypothesize that txt-cbt delivered in conjunction with sc will produce greater reductions in opioid use and hiv-risk behaviors, and will improve hiv treatment regimen adherence, relative to mm alone. further, the investigators expect that sc+txt-cbt will facilitate greater changes in negative affect, self-efficacy, and social support, and these changes will be associated with substance use outcomes. txt-cbt incorporates specific substance- and adherence-focused cognitive therapy techniques with a concurrent emphasis on reducing hiv-risk behaviors. by providing support to maximize hiv treatment regimen adherence, coupled with coping skills to address withdrawal symptoms and stress, two important factors in opioid relapse, txt-cbt may provide a promising, cost-effective, and easily deployable augmenting strategy for the treatment of opioid users who are hiv-infected.

Eligibility criteria:
inclusion criteria for participants in both phase i and phase ii will be: 1. age 18 or older; 2. dsm-iv diagnosis of opioid dependence; 3. hiv-infected serostatus; 4. able to provide informed consent; 5. willing and able to participate in study procedures, 6. good general health or, in the case of a medical/psychiatric condition needing ongoing treatment, potential participant should be under the care of a physician who provides documented willingness to continue participant's medical management and coordinate care with the study physicians. exclusion criteria: 1. lack of proficiency in english; 2. currently homeless (unless residing in a recovery home for which contact information can be provided); 3. dependence on an illicit substance for which medical detoxification is imminently needed. 4. presence of clinically significant psychiatric symptoms as assessed by mini, such as psychosis, acute mania, or suicide risk that would require immediate treatment or make study compliance difficult. -

Keywords: hiv opioid abuse mobile technology
telomeres parameters in celiac disease

Conditions: Celiac Disease

Summary: celiac disease is an autoimmune process that causes destructive changes in the epithel of the small bowel and it is also a pre-malignant state (e.g lymphoma). the aim of the study is to examine telomere length and other parameters of genetic instability from peripheral blood lymphocytes of patients with celiac disease compared with healthy controls.


Eligibility criteria:
inclusion criteria: * patients with celiac disease exclusion criteria: * known malignancy * cannot sign informed consent * under age 18

Keywords: celiac telomere telomerase
impact of life events and psychological stress in rheumatoid arthritis set-up : case-control study within a multifactorial and integrative psychological model

Conditions: Arthritis, Rheumatoid; Stress Disorder

Summary: rheumatoid arthritis (ra) is an inflammatory rheumatic disease that can lead to structural damage and handicap. the ra physiopathology is multifactorial, including genetic and environmental risk factors. the identification of environmental factors implication is crucial to understand the ra mechanism, and improves the diagnosis and the treatment of the disease.

the physiopathology of ra is multifactorial, implicating genetic and environmental factors. within the environmental factors, the exact role of psychological stress and life events on the onset of the disease is still under question. in clinical practice, patients usually report the occurrence of a stressing life event before the diagnosis of the disease (mourning, dismissal, divorce...). nevertheless, literature reviews present some discrepancies and did not lead to a clear identification of the role of psychological stress in ra onset. this is mainly due to the evaluation methods of stress within those previous studies, considering stress as a unique response of the organism without taking into account personal, sociological, biological or environmental history. the aim of the study is to analyze the impact of stress on the ra onset within an integrative model, to evaluate patient assessment of the stress, and to present strategies to fix it.

Eligibility criteria:
patients ra : inclusion criteria: * patients aged over 18 years old * patients affected by ra according to acr/eular 2010 criteria, with a disease duration less than 2 years. * speaking and understanding french language * being informed about the study and having given his oral consent exclusion criteria: * pregnant or breastfeeding women * patient who refuse to participate. control : inclusion criteria: * patients aged over 18 years old * patients with a visceral surgery for less than 2 years (appendectomy, cholecystectomy, bowel obstruction, hernia, eventration...) * speaking and understanding french language * being informed about the study and having given his oral consent exclusion criteria: * pregnant or breastfeeding women * patient who refuse to participate

Keywords: rheumatoid arthritis stress