Kornimate/medical-research-clean huggingface dataset:
factors associated with survival in patients having pneumocystis jirovecii

Conditions: Pneumocystis Jirovecii Infection

Summary: pneumocystis jirovecii is a fungus that can colonize the airways of some patients and be responsible for a disease called pneumocystosis in other patients and mainly in immunocompromised patients. pneumocystosis was mainly linked to hiv in the 1990s, but with the advent of new immunosuppressive molecules used in cancers or autoimmune diseases and with the increase in the number of transplants, the epidemiology has changed in recent years. studies on p. jirovecii-related mortality are only based on patients with pneumocystosis. as a result, patients who are simply colonized or patients who are sick but not treated are not taken into account in these studies. the investigators therefore wish to study the overall mortality at six weeks and at three months in all patients with a positive sample for p. jirovecii


Eligibility criteria:
inclusion criteria: * adult patients with a positive respiratory sample for p. jirovecii cared for in strasbourg university hospitals between 01/01/2016 and 31/12/2018. positive samples are defined as a direct examination finding cysts or trophozoites after staining with may-grunewald-giemsa and/or gomori-grocott, a positive p. jirovecii pcr on sputum, tracheal aspirates or bronchial fluid -alveolar * subject not objecting to the reuse of their data for scientific research purposes. exclusion criteria: - subject having expressed its opposition to the reuse of its data for scientific research purposes.

Keywords: p jirovecii infection pneumocystis infections pneumocystis jirovecii infection pneumocystis jirovecii pneumonia pneumocystis
intra-myometrial vasopressin during cesarean section in placenta previa

Conditions: Placenta Previa

Summary: placenta previa can have serious adverse consequences for the mother, including an increased risk of maternal mobility, antenatal and intrapartum hemorrhage, and the mother may, therefore, require a blood transfusion or even an emergency hysterectomy. although it is a relatively rare condition with an overall incidence of 0.28-2.0% of all deliveries, it has been suggested that the incidence of placenta previa is increasing. many gynecological surgeons use a local injection of vasopressin, which is a known peripheral vasoconstrictor, at the time of laparoscopic myomectomy to decrease blood loss. in addition, the useful role for local infiltration of vasopressin to arrest hemorrhage from the placental bed has been demonstrated in several obstetrical case reports. the vasopressin v1α receptor has been demonstrated to be present in the myometrium of both non-pregnant and pregnant women and contributes to myometrial contraction. therefore, the investigators evaluated the effect of local injection of vasopressin on the blood loss and secondary impact on complications during cesarean section in cases of placenta previa.

the study drug was administered immediately after delivery, as soon as the umbilical cord was clamped. the experimental group received a bolus injection of vasopressin (4 iu) diluted to 2 ml with saline into the myometrium of the placental bed during slow (30-seeconds) conversely, the placebo group received a 10-ml bolus injection of saline into the myometrium during slow (30-seconds).

Eligibility criteria:
inclusion criteria: * all pregnant women with a single term fetus scheduled for an elective cesarean section for complete placenta previa and invited them to participate in the study. the placenta previa was defined as a placenta completely covering the cervical os in ultrasound examination exclusion criteria: * patients with a cardiac, hepatic, renal or thromboembolic disease. * patients with the high possibility of the morbid adherent placenta. * known coagulopathy * those presented with severe antepartum hemorrhage will be excluded * hypersensitivity or contraindications of use of vasopressin * patient refuses to consent

Keywords: vasopressin placenta previa postpartum hemorrhage
effects of non invasive brain stimulation during prolonged experimental pain

Conditions: Pain; Prolonged Experimental Pain

Summary: non invasive brain stimulation (nibs) of the primary motor cortex (m1) through transcranial direct current stimulation (tdcs) has been widely investigated in research and clinical settings in order to modulate brain plasticity and improve clinical pain. interestingly, newly developed paradigms i.e. tdcs of the resting state motor network have proved higher modulatory effects in terms of corticospinal excitability when compared to traditional m1 tdcs. however, little is known about the effects of tdcs on the frequency changes of alpha oscillations (alpha peaks). interestingly, previous studies show a correlation between reduced frequencies of alpha peaks during 1-hour experimental pain in comparison to baseline. the present study aims to investigate the effects of tdcs of the resting state motor network on the frequency and power of alpha peaks during prolonged experimental pain during 24 hours.

there is evidence that chronic pain alters the frequency of alpha peaks. specifically, recent studies showed a correlation between decreased frequency of alpha peaks and perceived pain. furthermore, a correlation was found between high pain sensitivity and slower alpha oscillations during prolonged pain during 1 hour. to date, the effects of prolonged experimental pain during 24 hours on brain oscillations has not been explored. moreover, it is unknown whether non invasive brain stimulation (nibs) through transcranial direct current stimulation (tdcs) can revert these pain-related feature. it is hypothesized that prolonged pain during 24 hours will reduce the frequency of alpha peaks and tdcs of the resting state motor network will revert it to baseline values. furthermore, it is thought that decreased frequency of alpha peaks will be correlated with perceived pain intensity on day 1 (before receiving the first tdcs session).

Eligibility criteria:
inclusion criteria: * right-handed healthy men and women in the age 21-50 years who speak and understand english exclusion criteria: * lack of ability to cooperate * history of chronic pain or current acute pain * pregnancy * drug addiction defined as the use of cannabis, opioids or other drugs * present and previous neurologic, musculoskeletal or mental illnesses * chili allergies * current use of medications that may affect the trial * contraindications to rtms application (history of epilepsy, metal implants in head or jaw, etc.) * failure to pass the questionnaire for tdcs
implementation of online adaptive radiotherapy for breast cancer patients on ethos (breast-art)

Conditions: Breast Cancer

Summary: postoperative radiotherapy is for the majority of breast cancer patients the standard of care. during postoperative radiotherapy, unexpected dosimetric deviations can occur due to breast contour changes resulting from resorption of postoperative breast or chest wall seroma/hematoma, oedema either postoperatively or during irradiation, or arm/body positioning variation. in approximately 10% of cases, repositioning after setup imaging is not sufficient, and offline plan adaptation is required. when a new treatment planning is required in the standard offline workflow this will take in general 2 days. by using an online adaptive workflow with a daily treatment planning this delay and extra work caused by offline plan adaptation can be omitted. the aim of this study is to translate the offline adaptive workflow to an online adaptive workflow, and investigate the experiences of patients who have been treated with online adaptive radiotherapy for breast cancer (breast-art).

in this single-arm prospective breast-art study breast cancer patients with an indication for postoperative radiotherapy will be treated according to the dutch and institutional guidelines. target volumes will be the whole breast, chest wall, axillary levels, tumor bed boost and partial breast irradiation on the right side and left side with a deep inspiration breath hold technique. robust templates are developed for offline and online treatment planning with an imrt tangential multiple-beam setup. a simulation of the online adaptive workflow is performed in breast cancer patients already treated on the ethos-linac with the standard offline adaptive workflow. patients will be treated following the online adaptive workflow delivered on the ethos-linac. patient experience will be evaluated using an in-house developed questionnaires after the first and last fraction, scoring treatment satisfaction on a 4-point likert scale. furthermore, all dosimetric data, volume details, dicom images and the time spend on all parts of the online adaptive workflow will be evaluated.

Eligibility criteria:
inclusion criteria: * breast cancer patients referred for postoperative radiotherapy of the breast, chest wall, axillary levels, tumor bed boost or partial breast irradiation. * age of 18 years and older. * adequate understanding and communicating the dutch language. * written informed consent for use of routinely collected clinical data and to fill out questionnaires. exclusion criteria: * patients not suitable for postoperative radiotherapy

Keywords: breast cancer radiotherapy online adaptive postoperative
a study of bumetanide for the treatment of autism spectrum disorders

Conditions: Autism Spectrum Disorder

Summary: the investigators are going to carry out a randomized double-blind placebo-controlled trial to study the efficiency and mechanism of bumetanide on the treatment of children with autism spectrum disorder.

in consideration of the increasing number of autistic children and poor intervention effect in china, it is an urgent to find some effective medicine. some studies have reported bumetanide, a classic diuretic, could improve autistic behaviors in both animal model and humans; while the efficiency of bumetanide on chinese autistic chilren is unkonwn and the underlying mechanisms remain unfolding. the investigators aim at investigating whether bumetanide would improve the clinical symptoms in chinese children with autism within a safe dosage and further study the physiological mechanism beneath.the investigators will regularly assess the participants' autism-related symptoms during medication, as well as the adverse effects of each patient. the investigators will carry out genome-wide association analysis (gwas) from blood sample, related metabolites in nervous system and compare the concentration of the neurotransmitter in autistic brain before and after 3 months' treatmeat,and also will collect the eeg signal in autistic chilldren when the participants performing certain tasks before and after 3 months' treatment.

Eligibility criteria:
inclusion criteria: the patients, aged from 3 to 6 years old, were given the diagnosis of asd according to the diagnostic and statistical manual of mental disorders, fifth edition (dsm-v) , by a team of autism experts; scores for children autism rating scale (cars) were more than 30; signed informed consents were provided by parents. exclusion criteria: liver and kidney dysfunction; with a history of allergy to sulfa drugs; abnormal ecg; chromosomal abnormality; suffering from nervous system diseases (such as epilepsy, schizophrenia, and so on); using the melatonin treatment for sleep disorders or withdrawal less than three weeks.
rural moud telemedicine in primary care phase 1

Conditions: Opioid-use Disorder

Summary: the feasibility study (phase 1) will examine the implementation of telemedicine (tm) in six rural clinics in two states/regions with varying levels of obot capacity.

the dramatic increases in opioid overdose deaths across the nation, particularly in rural areas, call for a rapid expansion of access to medication treatment for opioid use disorder (moud).there is a need to study effective ways to expand treatment access and improve retention on moud in rural areas highly impacted by oud. telemedicine (tm) for moud offers an alternative or supplementary approach to delivering moud that may be suitable for rural clinics and patients with oud. the objectives of the feasibility study are to study ways of incorporating tm into primary care clinics and to evaluate the associated outcomes, based on ehrs from the clinics and the tm vendor (i.e., patient days on moud) and participant surveys (e.g., opioid use). additional outcomes of the feasibility study are feasibility and acceptability assessed from the perspectives of providers and participants via focus groups. a patient registry will be established in each clinic to track patients with oud diagnoses, and those in the registry will be provided the opportunity to consent for sharing identified ehrs and participating in the follow-up surveys.

Eligibility criteria:
inclusion criteria: * aged 18-80 years old, inclusive, at the time of the qualifying visit * with oud diagnosis * at least 1 visit to the participating clinics from 9 months before and 6 months after the date of intervention implementation

Keywords: medication treatment for opioid use disorder telemedicine rural areas
interest of karate kata practice on the self-esteem of patients living with hiv

Conditions: Patients Living With HIV

Summary: since ancient times, physical and sports activity has been recognized as bringing many health benefits. descriptive and interventional studies on physical activity are developing, demonstrating physical and psychological benefits for patients with various diseases. physical activity is effective in improving self-esteem in the general population. good self-esteem allows for better autonomy to manage a chronic illness. the benefit of physical activity in patients living with hiv has been the subject of several studies, notably outside france, and seems to improve the quality of life. we hypothesize that sport, especially karate kata, could improve self-esteem in patients living with hiv, and represent another non-drug aid, in patients living with hiv.


Eligibility criteria:
inclusion criteria: * patient living with hiv * patient seen in the infectious diseases department of le mans hospital, during a consultation or day hospitalization for hiv follow-up * aged 18 years and older * patients able to understand and to give informed consent to participate in the study * valid social security coverage * written and signed informed consent by the patient and investigator exclusion criteria: * refusal to participate to the study * pregnant or brest-feeding women * person subject to a legal protection measure * patient with psychiatric disease * patient under legal protection * medical contraindication to play karate kata

Keywords: hiv karate kata self esteem
the effect of intramuscular ventrogluteal injection training given by pecha kucha method

Conditions: Injection Site

Summary: the aim of this study is to determine the effect of intramuscular ventrogluteal injection training given with the pecha kucha method on the knowledge, skill and satisfaction levels of nursing students.

intramuscular injection is a very important intervention among basic nursing skills. intramuscular injection technique to the ventrogluteal region is one of the safest injection techniques. in teaching this technique, both the knowledge and skills of the students can be increased by using different education methods. this research will be carried out to determine the effect of intramuscular ventrogluteal injection training given with the pecha kucha method on the knowledge, skill and satisfaction levels of nursing students. method: data will be collected with the introductory information form, knowledge test for intramuscular injection to the ventrogluteal region, skill test for intramuscular injection to the ventrogluteal region, satisfaction visual analog (vas) scale. data will be collected face to face between march 2025 and may 2025.

Eligibility criteria:
inclusion criteria: * taking the fundamentals of nursing course for the first time * being between the ages of 18-25 * students who can speak and understand turkish fluently. * students who accept to participate in the study voluntarily. exclusion criteria: * students who have previously taken the fundamentals of nursing 1st year course. * students who are graduates of health vocational high school. * students who have transferred to the nursing department with the vertical transfer exam.

Keywords: pain nursing education injections, intramuscular
efficacy and safety of vildagliptin in combination with pioglitazone in patients with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: many people with type 2 diabetes cannot maintain target blood glucose levels when taking a single oral drug. the purpose of this study is to assess the safety and effectiveness of vildagliptin, an unapproved drug, in lowering overall blood glucose levels when added to pioglitazone in people with type 2 diabetes not at target blood glucose levels on either pioglitazone or rosiglitazone alone.


Eligibility criteria:
inclusion criteria: * blood glucose criteria must be met * previously responded, as defined by the protocol, to treatment with pioglitazone or rosiglitazone * body mass index (bmi) in the range 22-45 exclusion criteria: * type 1 diabetes * pregnancy or lactation * evidence of serious cardiovascular complications * evidence of serious diabetic complications * laboratory value abnormalities as defined by the protocol * known sensitivity to pioglitazone * other protocol-defined exclusion criteria may apply

Keywords: type 2 diabetes vildagliptin
piezosurgery and conventional rotary instruments on third molar surgery

Conditions: Impacted Third Molar Tooth

Summary: the aim of this study is to compare piezosurgery and conventional surgery in impacted third molar surgery and to determine its effect on postoperative outcomes and quality of life.


Eligibility criteria:
inclusion criteria: * asa i-ii * aged 18-35 * symmetrical class 2 position b according to winter and pell-gregory classification * asymptomatic lower third molar tooth with the same difficulty according to the yuasa difficulty index exclusion criteria: * individuals who had systemic disease affecting bone or soft tissue metabolism * smokers (more than 10 cigarettes a day * alcohol dependent * systemic disease affecting bone or soft tissue metabolism * acute pericoronitis or acute periodontal disease at the time of operation, and used antibiotics due to acute infection

Keywords: impacted tooth piezo-electric surgery postoperative complication
developing and evaluating a novel approach to improve hpv vaccination coverage among high-risk, under-immunized adults via the emergency department

Conditions: Human Papilloma Virus

Summary: to determine if the emergency department (ed) setting offers a viable space for improving hpv vaccination coverage among 18 to 45-year-old adults who have not yet received human papilloma virus (hpv) vaccination or who did not complete the vaccine series. this study will develop, pilot and evaluate an ed-based hpv vaccination protocol and program for ed patients aged 18-26 (for whom catch-up hpv vaccination is routinely recommended by the cdc) and separately for patients aged 27-45 (for whom it may be recommended under shared decision making, sdm).


Eligibility criteria:
inclusion criteria: * aged 18-45 years old * in good functional capacity, as determined by the ed-attending clinician * no known infection with hpv high risk strain types 6, 11, 16 and 18. exclusion criteria: * will not receive vaccine if participants lack mental clarity and if running a fever or in some pain. * patients aged \ 45 years of age. * female patients with abnormal hpv results (including those with the high-risk hpv strain types 6, 11, 16, and 18) as determined by a previous pap smear test or hpv test. * female patients who are known to be pregnant. * male patients with known cases of hpv-associated infections will also be excluded from the study

Keywords: gardasil 9 hpv
complications from left atrial appendage occluder

Conditions: Atrial Fibrillation; Cardiac Perforation; Cardiac Tamponade

Summary: the following case reported a rare complication of left atrial appendage perforation complicated by cardiac tamponade during laao device deployment and its corresponding surgical management


Eligibility criteria:
inclusion criteria: * 73-year-old woman with cha2ds2-vasc score 4 exclusion criteria: * nil
volume responsiveness before sbt predicts the outcome of mechanical ventilation weaning in critically ill patients

Conditions: Weaning Failure

Summary: to evaluate the performance of volume responsiveness in predicting the outcome of mechanical ventilation weaning in critically ill patients.

82 patients, 61 succeed and 21 failed

Eligibility criteria:
inclusion criteria: * mechanical ventilation exclusion criteria: * pregnancy or breast-feeding * tracheostomy at baseline * myasthenia gravis or acute polyradiculoneuropathy * end-stage chronic illness
myphonak app junior pediatric usability and benefit investigation

Conditions: Hearing Loss

Summary: participants age 8-17 with bilateral hearing loss will be fit with phonak bte (behind-the-ear) hearing aids and given access to the myphonak junior hearing app. the participants will use the app to adjust the hearing aid microphone and noise reduction settings.


Eligibility criteria:
inclusion criteria: * children and adolescents between the ages of 7 and 17 years old. * bilateral mild to severe hearing loss * experienced hearing aid users for 6+ months exclusion criteria: * any additional disabilities to the hearing impairment * inability to complete the study procedures
plethysmography variability index monitoring for parturients with antepartum hemorrhage

Conditions: Antepartum Hemorrhage

Summary: the purpose of this study is to evaluate the use of continuous noninvasive intraoperative plethesmography variability index in conjunction with hemoglobin levels monitoring using masimo radical-7™ pulse co-oximeter during elective cesarean sections in patients with antepartum and intrapartum hemorrhage as a guide for fluid and blood transfusion practice .


Eligibility criteria:
inclusion criteria: * anesthesiologist (asa) physical status i - ii. * patients aged from 18 to 40 years * full-term multigravida parturients * antepartum hemorrhage * singleton fetus exclusion criteria: * patients with known cardiac problem * peripheral circulatory failure of the upper extremities * significant liver disease * significant renal disease * significant coagulopathy
multicenter ab-interno glaucoma study investigating canaloplasty

Conditions: Primary Open Angle Glaucoma

Summary: a prospective, multicenter, randomized, single-masked clinical trial to evaluate the effectiveness outcomes of canaloplasty performed as a standalone procedure with the itrack microcatheter to the omni surgical system, and to compare the effectiveness of two types of ophthalmic viscoelastic device (ovd).


Eligibility criteria:
inclusion criteria: 1. diagnosed with mild to moderate open angle glaucoma. 2. visual field test (humphrey sita standard 24-2) with mean deviation better than or equal to -12.0 db 3. iop \< or = to 36 mmhg while on one to four ocular hypotensive medications 4. shaffer grade of \> or = iii in all four quadrants 5. able and willing to comply with the protocol and follow up visits for 12 months exclusion criteria: 1. laser trabeculoplasty other than selective laser trabeculoplasty (slt) 2. history of istent or istent inject within 180 days of the screening visit 3. history of ecp or micropulse laser 4. trabeculectomy or other bleb forming procedure including xen, express and glaucoma drainage device/valves 5. prior canaloplasty (ab interno and ab externo) 6. prior goniotomy or trabeculotomy 7. history of hydrus microstent or suprachoroidal stent 8. history of cataract surgery within 6 months of screening 9. acute angle closure, traumatic, congenital, malignant, uveitic or neovascular glaucoma, pigmentary or pseudoexfoliative glaucoma

Keywords: canaloplasty