Kornimate/medical-research-clean huggingface dataset:
evaluation of effectiveness of two different doses of mivacurium in rapid sequence intubation

Conditions: Emergencies

Summary: mivacurium can be considered as an optimal choice for muscle relaxation in short duration surgeries, as butyrylcholinesterase can rapidly and reliably degrade this benzylisoquinoline muscle relaxant in vivo. however the histamine release related to a rapid high-dose injection, unsatisfactory intubation conditions and unexpected delay in recovery in patients may be encountered with butyrylcholinesterase deficiency

intubation in emergency and full stomach patients stands as a challenge in anaesthesia. rapid sequence induction (rsi) is the key player technique in avoiding gastric contents aspiration risk. non-depolarizing neuromuscular blocking agents as mivacurium are of clinical significance in the anesthetic management of patient. mivacurium has been has been preferred in situations who necessitating hemodynamic solidity all over the surgery, as only transient tachycardia and hypotension were recorded aim of work using high doses of mivacurium can provide accepted condition of emergency intubation within favorable time - monitoring hemodynamics changes during and after intubation, time of recovery from high doses of muscle relaxant

Eligibility criteria:
inclusion criteria: * 20-60 year old patients. * american society of anaesthesia (asa) 1 and 2. * emergency surgery. exclusion criteria: * refusal. * allergy. * neuromuscular disease. * suspected desaturation. * severe cardiac disease. * severe pulmonary disease.

Keywords: mivacurium rapid sequence intubation emergency surgery
evaluation of efficacy and safety of sparc1401 in acute low back pain

Conditions: Acute Muscle Pain

Summary: a phase 2 randomized clinical trial to evaluate efficacy and safety of sparc1401 at three dose levels in patients with acute low back pain


Eligibility criteria:
inclusion criteria: * gives informed and written consent and is able to comply with all study assessments scheduled in the protocol * males or females aged 18 to 80 years (inclusive). * female subjects should be surgically sterile (bilateral tubal ligation at least 6 months prior to randomization, bilateral oophorectomy or hysterectomy performed) or if they are of child-bearing potential, should be willing to practice an acceptable method of birth control from screening to completion of study. * subjects will be considered eligible for this trial based on medical evaluation, electrocardiogram and laboratory values at screening, and laboratory values outside normal range considered of no clinical significance by the investigator exclusion criteria: * history or presence of clinically significant or uncontrolled cardiovascular, respiratory, neurological, psychiatric, hepatic, renal, gastrointestinal, hematological, or sleep disorder * history or clinical signs or symptoms suggestive of stenosing peptic ulcer, pyloroduodenal obstruction, or inflammatory bowel disease * history of diagnosis of cancer within 5 years prior to screening * history of narrow-angle glaucoma, symptomatic prostatic hypertrophy, or bladder-neck obstruction
effects of the covid-19 pandemic on fibromyalgia patients

Conditions: Fibromyalgia; Chronic Low-back Pain

Summary: in this study, the effects of the symptoms related to the diseases of patients with fibromyalgia during the covid-19 pandemic, their limitations in their social and business life, the need for different drugs, stress levels and the effect of the pandemic on the disease activity will be evaluated.

psychological stress caused by the covid-19 pandemic may contribute to the severity and duration of physical pain. however, when added to the economic stress due to social isolation, pain may worsen in patients with chronic pain, especially fibromyalgia, prone to anxiety and depression. due to the fact that many occupational sectors, which concern the whole society, have come to a halt, being obliged to live a sedentary life due to inability to perform their profession may have caused an increase in the body mass index of people. during the pandemic days, our concentration and health services may have shifted from the diseases of our branch to covid-19 and the branch health services offered may be disrupted. however, the call of the country administrators to stay home and the concept of social isolation caused the routine outpatient clinic follow-ups to be delayed. lack of sufficient data on how fibromyalgia patients were affected in previous pandemics and the pandemic we are in, the disease levels of the patients in this period, restrictions in their social environment, difficulties in reaching the doctor may have exacerbated the course of the diseases. in this study, the effects of the symptoms related to the diseases of patients with fibromyalgia during the covid-19 pandemic, their limitations in their social and business life, the need for different drugs, stress levels and the effect of the pandemic on the disease activity will be evaluated. the data to be obtained can be a guiding resource for us in the ongoing pandemic and in the fight against future pandemics due to the mutated genetic structure of the virus.

Eligibility criteria:
inclusion criteria: * patients aged between 18 and 65 years * patients who have low back pain lasting at least 3 months and started before pandemic * patients diagnosed with fibromyalgia for at least 6 months exclusion criteria: * patients diagnosed with major depression * patients who have a history of back surgery, fracture, infection, spinal stenosis * patients with malignancy

Keywords: fibromyalgia pandemic chronic pain
juvenile systemic sclerosis, a retrospective epidemiological study on a french cohort

Conditions: Juvenile Systemic Sclerosis

Summary: scleroderma is an inflammatory attack of the vessels leading to localized or multisystemic sclerosis. it is a rare autoimmune pathology in pediatrics. the incidence in pediatrics is very low (about 4 per million according to an american) and therefore the data on the pathology very poor, especially on the therapeutic level. the proposed immunosuppressive treatments are extrapolated from data in adults. the evolution of connectivity does not seem quite identical to the evolution of adult scleroderma, adaptation of treatments seems judicious. however, data on the evolution under therapy in children are still poor. complications related to the pathology, iatrogeny and diagnostic delay are the first causes of mortality from this pathology and deserve to be studied and if possible avoided. the main hypothesis of the research being to bring together the experiences of the various reference and competence centers in france concerning the clinical presentation, management and follow-up of children with systemic sclerosis.


Eligibility criteria:
inclusion criteria: * minor subject (\<18 years old) * diagnosis of systemic sclerosis between 01/01/2012 and 30/06/2022. * subject (and/or his parental authority) who has not expressed, after being informed, his opposition to the reuse of his data for the purposes of this research. exclusion criteria: - subject (or his parents) having expressed his (their) opposition to participating in the study

Keywords: systemic sclerosis juvenile systemic sclerosis immunosuppressive treatments
offsetting hippocampal degeneration in m-stbi

Conditions: Traumatic Brain Injury; Degeneration; Memory; Loss, Mild, Following Organic Brain Damage

Summary: the goal of this study is to establish the feasibility of an intervention designed to improve memory in patients who have experienced a moderate or severe traumatic brain injury (m-stbi) and to examine its effect on brain structures.

the purpose of this study is to establish the feasibility of a novel intervention, and explore biomarker predictors of neurodegeneration and response to the proposed intervention. this 16 week intervention utilises allocentric spatial navigation tasks to improve memory and counteract hippocampal neurodegeneration. this intervention will be administered in combination with neuropsychological assessments, mr imaging, and the analysis of genomic variants at two time points; 7 months post-tbi and 12 months post-tbi.

Eligibility criteria:
inclusion criteria: * an acute care diagnosis of tbi as determined by a medical professional, indicated by: * post-traumatic amnesia duration of 24 hours or more, and/or lowest glasgow coma scale score of \< 13 * positive clinical ct or mri scan * aged 18 to 65 * fluent in english * have the competency for fully informed consent by 6 months post-injury * have basic computer skills * have functional use of one upper extremity * have access to the internet exclusion criteria: * a neurological disorder other than tbi (e.g., stroke, dementia, tumor, neurodevelopmental disorder) impairing baseline awareness, cognition, or validity of follow-up and outcome assessment. * a systemic condition (e.g., lupus, diabetes, rheumatoid arthritis). * any contraindications to magnetic resonance imaging (mri) * you are experiencing language impairments (i.e., aphasia) from your injury
safety and long-term evaluation (up to 5 years) of first booster immunization with novartis' tbe vaccine for adults in adolescents and adults

Conditions: Tick Born Encephalitis

Summary: evaluate safety and immunogenicity of first tbe booster and long-term immunogenicity up to 5 years after first tbe booster


Eligibility criteria:
inclusion criteria: * healthy subjects who have completed study v48p7 exclusion criteria: * acute illness at day of immunization * general decrease in resistance * progressive neurological disorders * history of febrile or afebrile convulsions * major congenital defects * serious chronic illness * hypersensitivity to study vaccine * treatment with immunosuppressants or systemic corticosteroids, immunoglobulins, whole blood or plasma derivates

Keywords: tick born encephalitis, tbe, adults
clinical application of ctdna in early screening of breast cancer

Conditions: Breast Cancer

Summary: the investigators aim to evaluate the possibility of clinical application of ctdna detection in peripheral blood of normal people, benign breast disease patients and breast cancer patients, so as to act as the new techniques or indicators of early screening of breast cancer.


Eligibility criteria:
inclusion criteria: * written informed consent must be obtained and documented according to the local regulatory requirements prior to beginning specific protocol procedures. * age of at least 18 and at most 70 years. * normal people who works as the volunteers. * benign breast disease patients should be diagnosed with confirmed pathology after surgery. * breast cancer patients should be diagnosed with confirmed pathology after surgery, and with no clinical evidence of local recurrence or distant metastases. complete staging work-up within 3 months prior to registration, which should be earlier than tnm iia stage. * adequate organ function including normal red and white blood count, platelets, serum creatinine, bilirubin, and transaminases within normal range of the institution. exclusion criteria: * known hypersensitivity reaction to the investigational compounds or incorporated substances. * local recurrence and/or metastasis of breast cancer. * pregnant or lactating patients. patients of childbearing potential must have a negative pregnancy test (urine or serum) within 14 days prior to registration. * prior or concomitant secondary malignancy (except non-melanomatous skin cancer or carcinoma in situ of the uterine cervix). * other serious illness or medical condition that may interfere with the understanding and giving of informed consent and the conduct of the study. * concurrent treatment with other experimental drugs or any other anti-cancer therapy. * males.

Keywords: ctdna early screening copy number variants (cnv) low depth whole genome sequencing (ldwgs)
movement therapy and childhood obesity

Conditions: Obesity

Summary: the child health and sports center, meir medical center, has an intervention program to treat obese children. the program includes physical activity, nutritional intervention and behavioral treatment.the emphasis given in the center to physical activity and sport enables a strong connection with movement therapy. movement therapy allows obese children to face and cope with the psychological and emotional aspects of obesity. the purpose of this study is to evaluate the contribution of the movement therapy intervention to our program.

movement therapy is part of the multidisciplinary intervention. weekly one hour long sessions are conducted under the guidance of a certified therapists. the meeting includes physical movement aimed to address the emotional world of the obese child. using games, structured exercises and verbal processing. at the start and end of the evaluation the children will answer questionnaires to study: 1. behavioral questionnaires:emotional state: anxiety, depression, communication, self-esteem, quality of life and self-efficacy. 2. demographic questions . at the beginning and the end of the program a certified movement therapist will observe the children to estimate the change of emotional movement.weight, height and bmi are measured regularly in the center.

Eligibility criteria:
inclusion criteria: * overweight/obese children exclusion criteria: * child that do not want to take part in this study

Keywords: obesity movement therapy exercise behaviour
ascension pyrocarbon radial head study

Conditions: Degenerative Arthritis; Radial Head Fracture; Rheumatoid Arthritis

Summary: the proportion of patient successes with the carbon modular radial head at the 2-year evaluation is no lower than the proportion of patient successes with the metal radial head.

this investigation will include 179 patients (119 study devices and 60 control devices) enrolled at 15 active centers. in addition a subset of 24 ra patients will be enrolled and analyzed separately. the trial is designed as a randomized, non-inferiority study comparing results of the cmrh to results of the mrh. this will be a multi-site study with all patients either receiving the cmrh or the mrh. sequential enrollment of all patients meeting inclusion criteria and agreeing to be in the study will be enrolled. the patients will sign an informed consent agreeing to accept either the investigational or control device. in addition, the surgeon will not know which device the patient is to receive until the day of surgery in an attempt to further reduce bias. the surgeon will open an envelope at the time of surgery to determine if a cmrh or mrh will be implanted. additional efforts to eliminate bias in the study will include a final radiographic analysis by an independent observer experienced in reporting on orthopedic devices. the independent reviewer will grade the surgical implant and determine radiographic success/failure for each patient. implants will be assigned to patients at the clinical sites in a block randomization fashion. the randomization will be site specific. at a given site, each consecutive block of six enrolled patients to be treated will receive random assignments of cmrh or mrh at a 2:1. the randomization schedule is generated by computer (nquery) and is produced in blocks of 6, where 4 are study devices and 2 are control devices.

Eligibility criteria:
inclusion criteria: * patients must need a radial head replacement for: * degenerative, post-traumatic or rheumatoid arthritis * primary replacement after fracture of the radial head * relief of symptoms after radial head resection * revision of failed radial head arthroplasty * skeletally mature individuals ages 18 - 85 exclusion criteria: * inadequate bone stock or soft tissue coverage * previous open fracture or infection in the joint * individuals under age of 18 or over 85 years of age * physical interference with or by other prostheses during implantation or use * procedures requiring modification of the prosthesis * skin, bone, circulatory and/or neurological deficiency at the implantation site * prisoners * patients on chronic corticosteroid or non-steroidal anti-inflammatory therapy

Keywords: radial head arthroplasty
at-home cardiac rehabilitation for adolescents at risk for heart failure

Conditions: Cardiovascular Complication; Chemotherapeutic Toxicity

Summary: the goal of this clinical trial is to explore the impact that an at-home cardio-oncology rehabilitation (core) may have on short-term cardiovascular fitness and psychosocial wellness in pediatric cancer survivors. the main question it aims to answer are * to evaluate the efficacy of an at-home core model on short-term cardiovascular fitness and psychosocial wellbeing in adolescent cancer survivors. * to evaluate the exercise adherence rate among adolescents at risk for heart failure and assess barriers to compliance. * to explore which specific core resources are of most value to patients in creating sustainable healthy lifestyle modifications. * hypothesis: pediatric cancer survivors who implement exercise and dietary recommendations will demonstrate improvement in cardiovascular fitness and general wellness. a multidisciplinary team approach can facilitate adherence to a moderately rigorous exercise prescription, and thus enhance the health benefits of a core program at chla. participants will undergo cardiovascular studies and a quality-of-life survey prior to exercise intervention, and at the end of the 6-month study period.


Eligibility criteria:
inclusion criteria * patients aged of 10-21 years at enrollment * parent/legal guardian available for consent (if applicable), and patient available for assent and consent * history of anthracycline exposure +/- radiation * currently in remission, with at least 6 months off chemotherapy * able to perform cpet * baseline cpet with vo2 \<80% (at start of study, or cpet at chla after january 2020) * smartphone compatible with fitbit (own or parent/legal guardian's) * ability to complete and send diary and fitbit information on a weekly basis * ability to participate in monthly virtual check-in visits * baseline activity prior to intervention \<30min/day, 2x/week exclusion criteria * inability to obtain consent/assent * unable to accurately perform quality of life survey independently * no other primary medical diagnosis (e.g., down syndrome, wolff-parkinson-white syndrome, congenital heart disease) or history of cardiothoracic surgery * contraindication to moderate activity (\>3 mets). examples include history of malignant arrhythmias, exercise-induced syncope, severe symptoms of hf (nyha iv, acc/aha stage d) * unable to perform cpet, echocardiogram, ekg, or obtain laboratory studies * unable to perform mild activity for at least 0.5h/day and at least 2x/week * unable to come to hospital for study visits at 0 and 6 months * unable to complete study-related surveys * unable to complete and send diary and fitbit information on a weekly basis * unable to check-in monthly on virtual platform * on beta blockade * pregnancy

Keywords: anthracycline exposure cancer survivors physical activity pediatric oncology cardiac rehabilitation
a pilot study of shoulder subluxation treatment by using the self-designed surface functional electrical stimulator

Conditions: Stroke

Summary: the purpose of this study is to investigate the effects of the self-designed surface functional electrical stimulator on shoulder joint subluxation for stroke patients

functional electrical stimulation (fes) is a common and effective therapeutic approach for clinical treatments of shoulder subluxation. by applying low-frequency electrical stimulation to the target muscle groups, improvements may be observed in terms of muscle strength, subluxation, and passive humeral lateral rotation of the shoulder joint. in order to overcome issues regarding the integration of an fes and a rehabilitation robot, group members have designed a customized fes system approved by medical safety regulations. despite sharing identical specifications with commercial models, the approved 2-channel fes system provides better integrity and control when working with the upper extremity rehabilitation robot. in this study, three patients with unilateral shoulder subluxation will be recruited. limited shoulder x-ray photos shall be taken before, during, and after the fes shoulder subluxation treatment for studying the effects.

Eligibility criteria:
inclusion criteria: * stroke (1-3 months) * brunnstrom stage i-iii * single, unilateral exclusion criteria: * aphasic * shoulder impairment * severe osteoporosis * cardiac arrhythmias or having a pacemaker implanted * abnormal cutaneous sensation at the target areas
on-line neuromuscular exercise and education for knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: due to enforced social distancing as a direct consequence of the covid-19 pandemic, many on-site health care services are unavailable. this study seeks to investigate the relative effectiveness of an alternative on-line delivery model of exercise and education compared to on-site delivery in patients with knee osteoarthritis.

due to the extraordinary events of the 2020 covid-19 pandemic, finding alternative delivery-models of treatment has come to the forefront of public health services worldwide. consequently, on-line treatment is rapidly becoming an integral part of public health service. for patients with knee osteoarthritis (oa), where non-pharmacological and non-surgical treatment is considered first-line treatment, on-line delivered exercise has already shown promise and may be a viable treatment option, especially when traditional on-site exercise delivery models are unavailable. however, further studies are needed to clarify the relative effectiveness of on-line exercise and education when compared to on-site exercise and education programs. this study aims to evaluate the effects of on-line exercise and education in knee oa compared to a cohort of similar knee oa patients completing the same exercise and education program through on-site delivery. this study includes two cohorts of knee oa patients receiving the same exercise and education program through different delivery models (on-line vs. on-site). the on-line cohort is a new treatment delivery initiative, born out of the covid-19 enforced shutdown of all non-critical on-site health care. the on-site cohort is comprised of knee oa patients from a patient registry, collecting outcome data as part of the exercise and education program. the exercise and education program is called good life with osteoarthritis in denmark (gla:d), and consists of two to three disease-specific educational sessions and 12 neuromuscular exercise sessions (nemex-tjr). gla:d originates from denmark and has currently been implemented in australia, canada, china, switzerland and new zealand. this study will primarily compare outcomes of pain, function and quality of life between the two different treatment delivery models and will provide important insights in effectiveness of alternative delivery models of recommended first-line care for patients with knee oa.

Eligibility criteria:
inclusion criteria: * knee oa symptoms resulting in contact with the health care system exclusion criteria (both study groups): * another reason than oa for the problems; includes tumour or inflammatory joint disease * other symptoms that are more pronounced than the oa symptoms; i.e. chronic, generalised pain or fibromyalgia. in addition, for the on-line study group: * previous participation in similar exercise and education programs (i.e. the on-site version) * lack of necessary equipment or skills to administer on-line participation

Keywords: knee osteoarthritis exercise education on-line pain function quality of life