Kornimate/medical-research-clean huggingface dataset:
lidocaine infusion for postthoracotomy pain syndrome

Conditions: Thoracic Surgery, Video-Assisted; Lidocaine; Pain, Postoperative; Chronic Pain

Summary: this study seeks to investigate lidocaine infusion to reduce postthoractomy pain syndrome after thoracic surgery

postthoracotomy pain syndrome (pps) is defined as a persistent and/or recurrent pain or burning sensation along the thoracotomy scar at 3 months after surgery. the pain is very significant, given that 3 to 5% of postthoractomy patients report it as being severe, and approximately 50% of patients report limitations in their activities of daily living. little is known about the origin of this pain, but it seems that the intensity of acute postoperative pain is the best predictor of it. lidocaine infusion could be a possible approach to reducing the prevalence of pps. recently, a meta-analysis concluded a modest but statistically significant reduction of pain severity in the first four postoperative hours measured by the visual analogue scale (mean difference, -0.84; 95% ci, -1.10 to -0.59). however, a more recent meta-analysis found that only limited clinical data and biological plausibility support lidocaine infusions for the prevention of postoperative persistent pain (odds ratio, 0.29; 95% ci, 0.18 to 0.48). this study was designed to investigate whether lidocaine infusion after video-assisted thoracoscopic surgery (vats) would lower pps at postoperative 3 and 6 month.

Eligibility criteria:
inclusion criteria: * patients scheduled to undergo a muscle-sparing lateral minithoracotomy for different thoracic diseases exclusion criteria: * (1)asa classification status iii or above * (2)body weight\<35kg * (3)liver cirrhosis * (4)a history of previous thoracotomy * (5)pregnancy * (6)severe arrhythmia * (7)congestive heart failure * (8)opioid or steroid use 6 months before surgery * (9)allergy to lidocaine * (10)chronic pain syndrome (any type) * (11)emergency surgery * (12)incapacity to give an informed consent, visual dysfunction or severe mental disorders

Keywords: postthoracotomy pain syndrome chronic pain lidocaine
the impact of rph201 on cvs patients: clinical and fmri measurements

Conditions: Chronic Vegetative State

Summary: the investigators are studying the impact of rph201 on chronic vegetative patients. rph201 has been reported to induce neuronal regeneration in animal models. evaluation will be done by combining clinical /behavioral assessment with fmri studies.


Eligibility criteria:
inclusion criteria: * chronic vegetative patients exclusion criteria: * inability to go through an mri scans (i.e. metal implants, neurotransmitters)and pregnancy

Keywords: chronic vegetative state rph201 functional mri
asymptomatic renal calculi in recurrent urinary tract infections

Conditions: Urinary Tract Infections; Kidney Stone

Summary: this study will assess patients who have recurrent urinary tract infections and kidney stones which are not blocking the kidney or causing other problems. currently, we don't know if taking out these stones will improve recurrent urinary tract infections or not. patients will make a decision with their surgeon about removing or monitoring their stone(s). whether or not their infections continue with surgery or monitoring will be noted, and this information may help to inform future treatment decisions. the purpose of this study is to assess if treatment of these asymptomatic stones affects the rate of recurrent urinary tract infections.

urinary tract infections (utis) are common and have a large burden of disease at the population level. this study will assess the effectiveness of removing kidney stones in patients who have recurrent utis. the role of upper urinary tract calculi in utis is not well understood. although there is some evidence that some metabolic stones, such as calcium oxalate, can harbor bacteria, it is not known if this is clinically significant or if these contribute to clinical infections. this study aims to advance the level of evidence in the treatment of non-obstructing urolithiasis in the context of recurrent utis. the aim of this study is to: 1. assess the effects of treatment of non-obstructing upper urinary tract calculi on recurrent utis in the first prospective observational trial in this area patients who meet inclusion criteria will make a decision about treating their asymptomatic stones or not with their surgeon as per usual clinical care. the primary outcome will be the rate of recurrent urinary tract infections for patients, comparing patients who did and did not have their stones treated. patient data is securely stored in de-identified fashion in redcap database, following all the secure protocols of the institutions involved. the recruitment goal is 80 patients based on power calculations to detect the effect size. statistical analysis will be performed between the two groups, with t-test used for normally distributed numerical data and fisher's exact or chi-square tests for categorical data.

Eligibility criteria:
inclusion criteria (all of the following): * recurrent utis, defined as 3 positive urine cultures of specific organisms with symptoms within 12 months (or 2 positive cultures with symptoms within 6 months) prior to clinical assessment * non-obstructing renal stone(s) on imaging within 6 months of initial visit exclusion criteria: * age \< 18 years * pregnancy * hydronephrosis or evidence of obstruction * presence of a foreign body in urinary tract (e.g. foley, ureteral stent, nephrostomy tube) at the time of uti diagnosis * concurrent bladder calculi * urinary diversion or previous surgery involving segments of bowel interposed into the urinary tract (ileal conduit, ileal ureter etc.)

Keywords: urinary tract infection kidney stones urolithiasis
long term follow-up study to assess durability of sustained virologic response in alisporivir-treated hepatitis c patients

Conditions: Hepatitis C

Summary: the purpose of this study is to follow-up with participants from feeder studies who achieved sustained virologic response (svr) over 24 hours posttreatment (svr24), to assess durability of svr, and to assess the changes in liver disease, development of hepatocellular carcinoma and post-treatment safety over time. participants enter this study from feeder studies cdeb025a2210 (nct01183169), cdeb025a2301 (nct01318694), and cdeb025a2211 (nct01215643). they return to the site for up to 48 weeks with a maximum of 3 visits. no treatment is involved.


Eligibility criteria:
inclusion criteria: 1. provides written informed consent before any assessment is performed 2. is male or female aged ≥18 3. has previously completed a novartis-sponsored hepatitis c study and received alisporivir 4. has achieved svr24 5. is able to comply with the visit schedule exclusion criteria: 1. use of any investigational drugs within 5 half-lives of enrollment, or within 30 days of that medication, whichever is longer. 2. use or planned use to start a new course of hepatitis c therapy. 3. no additional exclusions are to be applied by the investigator, in order to ensure that the study population is representative of all eligible patients.

Keywords: chronic hepatitis c
resection margin of transverse colon cancer with extracorporeal versus intracorporeal anastomosis

Conditions: Transverse Colon Cancer

Summary: the approach of anastomosis in laparoscopic resection of transverse colon cancer (tcc) has rarely been discussed. this study aims to compare the resection margin of tcc with extracorporeal anastomosis (eca) versus intracorporeal anastomosis (ica). patients who underwent laparoscopic resection of tcc from august 2019 to july 2021 in 13 participating centers are included in this study. according to the approach of anastomosis, patients are divided into two groups, eca group and ica group respectively. the clinical characteristics, the perioperative outcomes and the pathological results (especially the length of resection margin) are compared between the two groups. the length of two-sided resection margins (long margin, short margin) are measured on formalin-fixed specimens and those with short margin less than 4.0 cm are defined as unqualified specimens.

13 participating centers are as follows: ruijin hospital, shanghai jiaotong university school of medicine；zhejiang university medical college affiliated sir run shaw hospital；zhongshan hospital affiliated to fudan university；renji hospital affiliated to medical college of shanghai jiaotong university; jiangsu provincial people's hospital; xiangya hospital of central south university; the first affiliated hospital of chongqing medical university; the first hospital of jilin university; beijing friendship hospital affiliated to capital medical university; tangdu hospital; tongji hospital affiliated to tongji medical college of huazhong university of science and technology; cancer hospital of chinese academy of medical sciences; henan provincial people's hospital

Eligibility criteria:
inclusion criteria: * 1. pathologically confirmed adenocarcinoma of colon * 2. the tumor is located in the transverse colon (including hepatic or splenic flexure); * 3. one of the following procedures was performed: transverse colectomy, right hemicolectomy, enlarged right hemicolectomy, left colectomy, enlarged left colectomy; * 4. laparoscopic surgery (laparoscopy-assisted surgery or complete laparoscopic surgery) from august 2019 to july 2021; * 5. radical resection (r0) was accomplished; exclusion criteria: * 1. simultaneous multiple colorectal cancer; * 2. history of colorectal surgery (except endoscopic surgery); * 3. robot-assisted surgery; * 4. palliative resection (non-r0 resection) or palliative bypass; * 5. the approach of anastomosis could not be determined from the documents; * 6. the length of resection margin was not recorded in pathological report;
nursing teleconsultation for patients with heart failure

Conditions: Heart Failure

Summary: the incidence and prevalence of heart failure are increasing and represent a large portion of hospitalizations in brazil, are also associated with high rates of morbidity, mortality and costs for the service of health. such data, added to the current scenario of the pandemic caused by covid-19, reveal the need for changes in clinical practice, so that health care is more effective and cost-effective and reaches patients without exposing them to risks. thus, the application of nursing interventions through of telephone technology, which has strong evidence of effectiveness found in the literature, has become an alternative for the implementation of clinical interventions. objective: evaluate the effectiveness of nursing consultations performed remotely in improving quality of life and adherence to therapy of patients with hf due to cardiomyopathy of different etiologies. method: the study will have as methodological framework the randomized clinical trial, with the recruitment of 60 volunteers with a diagnosis of chagasic hf, hypertensive or idiopathic, who are monitored at the outpatient clinic of clinical unit of cardiomyopathies and aortic diseases or clinical unit of hypertension, incor-hcfmusp, included by drawing lots into two groups. group a (n=30) will be monitored in biweekly nursing consultations by a period of three months added to the outpatient follow-up, and group b (n = 30) will follow the usual outpatient follow-up. hypothesis: patients hf carriers who periodically make telephone consultations of nursing have better quality of life and better therapeutic adherence when compared to patients who only have regular follow-up.


Eligibility criteria:
inclusion criteria: * patients already registered in a database of the clinical unit of cardiomyopathies and aortic diseases, incor - hcfmusp and clinical hypertension unit - hcfmusp, in outpatient follow-up for more than a year; * stroke volume \ 25% exclusion criteria: * patientes with pacemaker, defibrillators, implantable and cardiac resynchronization therapy * listed in heart transplant queue * not having technological devices that allow the teleconsultation to be carried out * psychic inability to understand the questionnaires and answer the questions asked by the interviewer

Keywords: nurse teleconsultation heart failure
hear me read 2021 clinical trial

Conditions: Hearing Loss; Deafness; Hearing Disorders in Children; Hearing Impaired Children; Speech Therapy; Speech Disorders in Children; Literacy

Summary: the purpose of this study is to evaluate if the effects of in-person speech-language therapy with a novel digital storybook intervention platform (hear me read) improves vocabulary, speech and language, and literacy outcomes in young children who are deaf or hard of hearing compared with in-person therapy alone.

for this study, 50 children, who are deaf/hard of hearing, and their caregiver will be enrolled into 2 separate 6-month intervention periods, for a total of 12 months of participation. there are two intervention periods in this study, intervention period 1 (slt) and intervention period 2 (slt+digital). each one lasts about 6 months and every participant will participate in both intervention periods. intervention period 1 is the speech-language therapy (slt) only intervention. during this intervention, the child will go to speech therapy as normally prescribed by their speech language pathologist. there will be standardized reading time that is prescribed at 20 minutes, 3 times a week and will be completed at home by the child and caregiver. intervention period 2 is the speech-language therapy with the hear me read (slt+digital) intervention. during this intervention, the child will continue to go to speech therapy as they typically would, but will be asked to use the hear me read app. there will be standardized reading time that is prescribed at 20 minutes, 3 times a week and will be completed at home by the child and caregiver using the hear me read app.

Eligibility criteria:
inclusion criteria: * male and female children ages 3.0-5.11 (5 years and 11 months) at time of initial assessment and: * bilateral sensorineural or mixed hearing loss at least (pta≥30db) * auditory neuropathy in both ears exclusion criteria: * english not primary language * standard score cls \>2 sd from normal on celf-p3

Keywords: app speech and language tablet digital literacy hearing loss speech therapy
incidence and risk factors for hospitalization-associated disability

Conditions: Functional Decline; Hospitalization-associated Disability; Iatrogenic Disease

Summary: this prospective cohort study aims to determine the incidence of hospitalization-associated disability and its association with risk factors at the patient level and with care and hospital processes. for this, patients aged 70 years or older admitted for elective valve surgery or elective transcatheter aortic valve implantation or as a result of symptomatic moderate to severe valvular heart disease will be consecutively included from 01 october 2015 to 29 february 2016.


Eligibility criteria:
inclusion criteria: * aged 70 years or older * admitted for elective heart valve surgery (replacement, repair or combined with cabg) or if admitted for elective transcatheter aortic valve implantation, or if a patient presents with symptomatic moderate to severe valvular heart disease on hospital admission as evidenced by moderate to severe valve regurgitation (≥ 2/4) or aortic valve area ≤ 1cm2 or mitral valve area ≤ 1.5cm2 and if one of the following symptoms is present: heart failure, decreased exercise tolerance, (exertional) dyspnea, (exertional) angina, (exertional) syncope * dutch speaking exclusion criteria: * life expectancy less than 6 months * expected length of stay less than 48 hours

Keywords: aged frail functional decline impairment valvular heart disease cohort risk factors
adrn barrier/immunoprofiling exploratory pilot study

Conditions: Dermatitis; Dermatitis, Atopic; Eczema; Non-atopic Healthy Controls

Summary: the purpose of this study is to look at how defects in the skin barrier and immune response affect risk for skin infections. participants will be classified into 4 groups based on atopic dermatitis (ad)/non-atopic (na) status and staphylococcus aureus (s. aureus) colonization (negative or positive): * ad s. aureus negative * ad s. aureus positive * na s. aureus negative and * na s. aureus positive.

atopic dermatitis, also called eczema, is a disease in which the skin is dry and scaly with severe itching. people with atopic dermatitis have defects in the skin barrier as well as defects in the immune system which fights off skin infections. people who have atopic dermatitis often have complications from viral and bacterial skin infections, such as recurring staphylococcus aureus (s. aureus), or staph infections. the study will compare the skin barrier and immune response of people with and without atopic dermatitis in relation to whether staph bacteria is growing on their skin.

Eligibility criteria:
inclusion criteria: participants fulfilling all of the following criteria are eligible for enrollment- * non-hispanic caucasian males and females 18 to 60 years of age, inclusive, at the time of enrollment * who are enrolled in the adrn registry study * who have active ad (lesions present) with or without a history of eczema herpeticum (eh) as defined in the adrn standard diagnostic criteria or who meet criteria for the na diagnostic group as defined in the adrn standard diagnostic criteria * who are willing to sign the informed consent form prior to initiation of any study procedures. exclusion criteria: participants fulfilling any of the following criteria are not eligible for enrollment- * who are pregnant * who have an active systemic malignancy. uncomplicated non-melanoma skin cancer and melanoma in situ with documentation of complete excision are not exclusionary * who have any skin disease other than ad that might compromise the sc barrier (e.g., bullous disease, psoriasis, cutaneous t cell lymphoma \[also called mycosis fungoides or sezary syndrome\], dermatitis herpetiformis, hailey-hailey, or darier's disease) * who have a history of systemic immunological illness (e.g., human immunodeficiency virus \[hiv\] or systemic lupus erythematosus \[sle\]) other than the condition being studied * who have active eh or eczema vaccinatum (ev) * who have a history of serious or life-threatening reaction to latex, tape, or adhesives * who are determined to be not eligible based on the opinion of the investigator.

Keywords: dermatitis staphylococcus staphylococcus aureus dermatitis, atopic non-atopic controls
safety and efficacy of defocus distributed multi-point lens in myopia control

Conditions: Myopia

Summary: evaluate the safety and effectiveness of experimental group by comparing with the control group

compared the experimental group with the control group,the safety and effectiveness of ddm lens in mtopia control will be evaluated.

Eligibility criteria:
inclusion criteria: * aged 6-13,with written consent of his/her guardian,regardless of gender; * objective cycloplegic spherical equivalent refractive between -1.00d and 5.00d,and best corrected vision acuity of right and left eyes are better than or equal to 1.0; * astigmatism less than or equal to -1.50d; * voluntarily participate in the clinical trial and sign the informed consent. exclusion criteria: * those with a history of ocular trauma or intraocular surgery; * clinical significant slit-lamp findings; * abnormal iop(\ 21 mmhg or difference between two eyes \>5mmhg); * patient with other eye diseases,such as uveitis and other inflammation,glaucoma,cataract,fundus disease,eye tumors,eye trauma,strabismus and any lesions that affect vision function; * patient with systemic diseases causing immunosuppression,such as acute or chronic sinusitis,diabetes,down syndrome,rheumatoid arthritis,psychosis and other conditions that the investigator considers inappropriate for wearing glasses; * those who have participated in other drug clinical trials within 3 months; * only one eye meets the inclusion criteria; * those who cannot have regular eye examinations; * those who have been involved in any myopia control clinical trials,previously used or are using rgp,contact lens and glasses or atropine drugs to control myopia in the past year; * the candidates determined by the investigator are not eligible.
no sensor to record wound data in acute or chronic wounds

Conditions: Volumetric Muscle Loss

Summary: the purpose of this research is to evaluate the ability of a nitric oxide (no) sensor to collect no measurement data from an open wound. previous research suggests that no levels may indicate the stage of healing the wound is in. this study is being done to determine if the no sensor can measure how much no is in a participant's wound. the researcher will place the no sensor into a participant's wound to collect no measurements for 30-60 minutes. the participant will then have 2 follow-up appointments to see how the wound heals over time.


Eligibility criteria:
inclusion criteria: 1. extremity injury 2. wound surface area 2-10 cm in diameter 3. wound amenable to no sensor placement 4. age at the time of consent ≥ 22 to ≤ 65 years 5. cognitively able to undergo informed consent discussion and understand the study exclusion criteria: 1. chemotherapy 2. pregnancy 3. preexisting immunosuppressive conditions or immunosuppression therapy 4. active hemorrhage in the wound bed 5. physician discretion for patients with complex medical conditions or high mortality risks 6. patients with an active implanted device, such as a pacemaker, defibrillator, or hypoglossal or vagal nerve stimulator 7. patients requiring a legally authorized representative (lar) for informed consent