Kornimate/medical-research-clean huggingface dataset:
correlation of early postoperative scar appearance with long-term scar outcomes

Conditions: Scar; Surgical Wound; Quality of Life; Mohs Micrographic Surgery; Skin Cancer Face

Summary: a retrospective cohort study of early and late period postoperative scars using previously validated survey measures and clinical photographs. the target population consists of participants treated with mohs micrographic surgery (mms) for a facial skin cancer by the division of dermatologic surgery. this study aims to determine if patient assessment of scar appearance correlates with physician ratings and/or third-person observer ratings. secondary goals are to assess for correlations between early post-operative scar appearance and long-term scar appearance as well as identification of predictive factors for scar healing.

scarring is an inevitable outcome of surgical manipulation of the skin. previous studies have shown that postoperative scarring, especially in cosmetically sensitive areas, may negatively affect patient quality of life and social interactions. the impact of surgical scarring is magnified in mohs micrographic surgery, for which the large proportion of treated lesions are in highly visible areas, such as the head, face, and neck. clinicians often underestimate the significance of scarring in patients' daily activities. patients desire quick healing surgical scars in order to reintegrate into their normal social routines. anecdotal evidence suggests that scars that heal well early in the post-operative period will achieve better results in the late postoperative period. determining a model of early and late surgical scar evolution, as rated by patients, physicians, and third-party observers may; 1. identify gaps between physician and patient evaluations; 2. assist clinicians in effectively evaluating and counseling patients regarding their post-operative scar appearance.

Eligibility criteria:
inclusion criteria: * adult participants diagnosed with a biopsy-proven facial skin cancer (melanoma and non-melanoma skin cancers) and treated with mohs micrographic surgery (mms) from august 2015 to february 2016. exclusion criteria: * participants with post-excisional reconstruction requiring multiple techniques, incomplete or missing patient photographs from postsurgical visits, or if the patient received any postoperative scar interventions (pulse-dye laser, scar revision, etc.).
oblique k-wire control in calcaneal osteotomy for flatfoot correction

Conditions: Flat Foot

Summary: adult-acquired flatfoot deformity (aafd) often requires surgical correction when conservative methods fail. calcaneal displacement osteotomy is a key procedure in restoring alignment. this study introduces a novel k-wire technique to enhance control during surgery and minimize complications related to manual manipulation. it builds on prior research highlighting the limitations of traditional approaches in achieving precise fragment positioning.

flat foot deformity, particularly adult - acquired flatfoot (aafd), often necessitates surgical intervention when conservative treatment fail. calcaneal displacement osteotomy is a common surgical procedure for correcting calcaneal displacement and achieving stable fixation. the proposed k-wire technique offers a novel approach to improve control and reduce complications associated with manual manipulation during surgery. previous studies have indicated challenges with traditional methods in achieving precise fragment control. this study aims to address these gaps.

Eligibility criteria:
inclusion criteria: * symptomatic flatfoot that will undergo flatfoot correction with calcaneal displacement osteotomy. exclusion criteria: * prior foot surgery * severe comorbidities or contradictions of the surgery

Keywords: flat foot calcaneal osteotomy
acute exposure to high altitude on exercise capacity

Conditions: Pulmonary Hypertension

Summary: randomized crossover trial in patients with pulmonary hypertension (pah, cteph) to assess the acute response to high altitude (2500m above sea level) in constant loaded exercise capacity.

low altitude baseline measurements will be performed in zurich (460m asl) including echocardiography, right heart catheterization, 6mwt, pulmonary function test, clinical assessment and blood gas analysis. randomly assigned to the order of testing, the participants will be tested in low altitude (zurich, 470m) and at high altitude (2500m). towards the end of the exposure after approximately 4 hours, the participants will perform a constant loaded exercise test on an ergometer with a calculated resistance of their 60% max workload. the patients will be encouraged to perform these tests up to their physical exhaustion.

Eligibility criteria:
inclusion criteria: * informed consent * ph diagnosed according to internation guidelines: mpap ≥ 25 mmhg along with a pawp ≤15 mmhg during right heart catheterization at the time of initial diagnosis * ph class 1 (pah) or 4 (cteph) * stable condition, on the same medication for \> 4 weeks * patient live permanently at an altitude \< 1000m asl. exclusion criteria: * resting pao2 ≤7.3 kpa corresponding to the requirement of long-term oxygen therapy \> 16hour daily (nocturnal oxygen therapy alone is allowed) * severe daytime hypercapnia (pco2 \> 6.5 kpa) * susceptibility to high altitude related diseases (ams, hape, etc.) based on previous experienced discomfort at altitudes. * exposure to an altitude \>1500m for ≥3 nights during the last 4 weeks before the study participation * residence \> 1000m above sea level * inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, neurological or orthopedic problems with walking disability * women who are pregnant or breast feeding

Keywords: exercise capacity high altitude contant loaded exercise test
community active and healthy families

Conditions: Obesity, Childhood

Summary: to address childhood overweight disparities among latino children in immigrant families a pilot trial of a community-based obesity treatment program, community active and healthy families (ahf), among 5-12 year old overweight and obese latino children in immigrant families using pre/post design will be conducted. the hypothesis is that children participating in community-ahf will demonstrate a reduction in child body mass index as measured by %bmip95 (primary outcome) and improved diet physical activity behaviors (secondary outcomes) at intervention completion compared with pre-intervention

to address childhood overweight disparities among latino children in immigrant families a pilot trial of a community-based obesity treatment program, community active and healthy families (ahf), among 5-12 year old overweight and obese latino children in immigrant families using a pre/post design will be conducted. as this is a pilot study, the study will not be powered to detect statistically significant differences pre- and post- intervention. the investigators will measure the average change in %bmip95 between baseline and completion of the community-ahf active phase. without a counterfactual (control group) the investigators will not be able assign responsibility to community-ahf for any observed improvements. change in %bmip95 across the study period will provide data to test our hypotheses and will inform statistical power analyses for a subsequent trial. this pre- and post-intervention data is ideal for generating sample size estimates for a larger randomized control trial in the same population. the investigators will conduct within-individual analyses for each outcome of interest. the investigators will only analyze participants who contribute pre and post measures in order to avoid biases that can occur when analyses are conducted with all available data. for each outcome for which a participant contributes pre and post measurements, the investigators will calculate pre and post means, standard deviations, differences in means and the p-value of the difference. the investigators will conduct preliminary analyses of outcomes according to subgroups defined by rate of attendance at intervention sessions. if adequate data are available, the investigators will explore the possibility of a nonresponse analysis.

Eligibility criteria:
inclusion criteria: * child age 5-12 years with parent/caregiver age of 18 or more years * child bmi \>/= 85th percentile for age * parent is foreign-born, self identifies as latino/hispanic and speaks spanish * parental commitment to participate in a 4-month intervention exclusion criteria: * child health condition that prevents diet modification or engaging in physical activity * child bmi \>40kg/m2
evaluation of long-term coronary stenting outcomes in diabetic patients with or without optimal glycemic control

Conditions: Diabetes; Coronary Artery Disease

Summary: the purpose of this study is to determine whether appropriate control of diabetes around the pci time is related with mace and outcome of diabetic patients.

despite recent advances in coronary revascularization, cardiovascular disease accounts for about 75% of all hospital admissions in diabetic patients.although the introduction of drug-eluting stents has reduced the rates of restenosis after pci, diabetic patients undergoing pci will have poorer clinical outcomes.in this study, we sought to investigate whether a pre and post procedural glycemic control in diabetic patients,as reflected by hgba1c prior,1 and 6 months after elective pci,was related to major advance cardiac events (mace) during 3 year follow up.

Eligibility criteria:
inclusion criteria: * age between 18-75 * coronary stenosis \> 70% exclusion criteria: * myocardial infarction in 72 hours prior to pci * lvef \< 30% * residual stenosis\>30% * cr level \> 2.0 * hemodynamic compromise during intervention * left main lesions * pci for vein grafts
vitamin d in fatty liver disease

Conditions: Non-alcoholic Fatty Liver Disease; Vitamin D Deficiency

Summary: this study evaluates the influence of vitamin d in reducing laboratory, elastographic (fibroscan) and metabolic components of nafld. half of the patients will receive vitamin d (plivit d3) while the other half will receive placebo

in this study will participate patients who come to the regular ambulatory examinations (referred by gastroenterologists, or family physicians in the department of gastroenterology chc rijeka) and have one or more components of the metabolic syndrome (hypertension, diabetes, obesity, dyslipidemia).nonalcoholic fatty liver disease will be defined by transient elastography (fibroscan, echosens, paris); controlled attenuation parameter (cap) for assesment of liver steatosis and liver stiffness measurements (lsm) for liver fibrosis. in all patients other causes of chronic liver disease will be excluded; chronic viral hepatitis, autoimmune diseases and other metabolic liver diseases as well as use of drugs than can cause liver steatosis and fibrosis and alcoholic liver disease. this study will include 450 patients. taking into account the possible drop-out rate around 15% of the patients during the study period, a total of 400 patients will be randomized. patients will be randomized into two groups. the first group will be consisted of the patients with nafld who will be receiving original medication during the 12 month period. the second group will be consisted of the patients with nafld who will be receiving placebo during the 12 months period, which will be identical to the original medication in its packaging and form. after the 6 and 12 months of therapy in all patients will be evaluated: liver enzymes and metabolic laboratory parameters of nafld (insulin resistance, lipidogram and serum glucose), as well as the te-cap in order to evaluate the efficiency of plivit d3 for the treatment of nafld.

Eligibility criteria:
inclusion criteria: * patients with non-alcoholic fatty liver disease (nafld) * signed informed consent * possibility to follow instruction and the protocol exclusion criteria: * chronic b or c hepatitis * usage of hepatotoxic drugs in the period of 6 months before inclusion * chronic kidney insufficiency (grade 4 and 5), hemodialysis * any other chronic liver disease * opioid dependancy * any malignancy * hiv seropositivity * alcohol abuse * pregnancy * inability to follow the protocol
mindfulness and education in patients with non-oncological orofacial pain

Conditions: Oro-Facial-Digital Syndrome

Summary: to analyze the effects of a program based on mindfulness plus pain neurophysiology education versus a program based on pain neurophysiology education on perceived quality of life, pain, sleep quality, and functionality, in adult patients with non-cancer orofacial pain.

this research corresponds to an experimental study, a double-blind randomized controlled clinical trial, where a total of 50 men and women, over 18 years of age, will be evaluated, divided into two groups: the experimental group will receive a mindfulness-based intervention, plus a program education in neurophysiology of pain, lasting 8 weeks; and the control group will only receive an 8-week pain neurophysiology education program. the variables will be measured for both groups with the same validated tools and the same investigator to avoid information biases and differential incorrect classification. the evaluations will be carried out at the beginning of the intervention and immediately after the end of this period, and the results will be recorded in a data record that will later be unified in an excel database, recording a code for each participant to maintain condition of privacy, but at the same time allow the required comparability. for the independent variables, the sociodemographic characteristics will be addressed; on the other hand, the outcome variables will be the health-related quality of life \[hrqol\] with the sf36 questionnaire, the pittsburgh index for sleep quality, the vas scale for pain, and the craniofacial pain and disability inventory (cfpdi) for pain and functionality. once the intervention is finished, the final evaluation will be carried out and from the comparative process define if there are significant differences with respect to the results initially obtained.

Eligibility criteria:
inclusion criteria: * men and women older than 18 years, who voluntarily agree to participate in the study, with orofacial pain of more than 24 weeks of evolution, of non-oncological origin. exclusion criteria: * oncological origin of orofacial pain. systemic diseases with a focus on the tmj. patients operated on atm. population that does not agree to participate in the study or who at the time of entering the program have denied the endorsement of the use of their data for research in the informed consent.
dose escalation study of sh u04722 in solid tumors

Conditions: Tumors

Summary: this study will evaluate the safety and tolerability of sh u04722 in patients with solid tumor cancers. in addition, this study will identify the recommended dose and administration schedule of sh u04722 for phase ii development in japanese cancer patients, evaluate the pharmacokinetic profile of sh u04722 and gather preliminary data on the effectiveness of sh u04722 in patients with solid tumors.

the study has previously been posted by schering ag, germany. schering ag, germany has been renamed to bayer schering pharma ag, germany.bayer schering pharma ag, germany is the sponsor of the trial.

Eligibility criteria:
inclusion criteria:-refractory to conventional antineoplastic treatment or no standard therapy option available-ecog performance status score of \< 2-agreement not to take vitamin e products such as juvela (except for over-the-counter \[otc\] and diet supplements). exclusion criteria:- patients treated with other unapproved drugs/investigational drugs, chemotherapy, biological response modifiers, immunotherapy or endocrinotherapy within 4 weeks prior to entry in this study or nitrosoureas within 6 weeks before initial dosing of sh u04722 -patients on concurrent therapy with warfarin or coumarin derivatives.-patients who had radiation therapy within 2 weeks prior to entry into this study. -patients with a history of serious hypersensitivity to taxanes.-patients with current peripheral neuropathy (? common terminology criteria for adverse events \[ctcae\] grade 2)

Keywords: paclitaxel advanced solid tumors
the bacteriuria in renal transplantation (birt) study: a trial comparing antibiotics versus no treatment in the prevention of symptomatic urinary tract infection in kidney transplant recipients with asymptomatic bacteriuria

Conditions: Asymptomatic Bacteriuria; Bacteriuria; Urinary Tract Infections; Kidney Transplantation

Summary: the purpose of this study is to compare antibiotics versus no-treatment in kidney transplant recipients with asymptomatic bacteriuria.

the birt trial investigators would be interested to collaborate with some additional hospitals, particularly centers having high level of antimicrobial resistance.

Eligibility criteria:
inclusion criteria: * kidney transplant recipient with asymptomatic bacteriuria after the first two months post-transplantation exclusion criteria: * pregnant women or women who wish to become pregnant during the course of the study * presence of indwelling urinary devices such as urethral catheter, ureteral catheter, nephrostomy and/or suprapubic catheter * combined transplantation (liver-kidney, lung-kidney, heart-kidney) * urinary tract surgery during the last two months * surgical urological procedure planned in the next 2 weeks * neutropenia (≤ 500 neutrophils/mm3) * important intensification of immunosuppression (solumedrol bolus and/or use of thymoglobulin) or any other treatment of an acute graft rejection in the last two months * use of antibiotics at the time of the asymptomatic bacteriuria (except for prevention of pneumocystis jirovecii) * end-stage renal disease (esrd) requiring dialysis * non-functioning native bladder (e.g. bladder dysfunction requiring intermittent self-catheterization, orthotopic ileal neobladder) * recurrent acute graft pyelonephritis (≥ 2 episodes in the last year) * kidney transplant recipients who could not return for regular follow-up
prospective and retrospective cohort study of new prognostic factors with peripheral blood and bone marrow evaluation at the time of diagnosis and during treatment or thereafter in acute leukemia (acute leukemia hsct cohort)

Conditions: Acute Leukemia

Summary: the objective of this study is to evaluate the prognostic factors of acute leukemia patients received stem cell transplantation and to invent the molecular genetic test for sensitive detection of minimal residual disease, and thereby this study would contribute to plan the risk adapted treatment. patients will have samples of blood and/or bone marrow collected during treatment or thereafter


Eligibility criteria:
inclusion criteria: * patients diagnosed with acute leukemia who underwent allo-hsct in severance hospital. * both genders of 16 years and older * sign a written informed consent document * exemption of consent in patient who died in study period. exclusion criteria: * no comprehension or willingness to sign a written informed consent document.
virtual reality (vr) therapy for post-traumatic stress disorder (ptsd)

Conditions: Post-Traumatic Stress Disorder

Summary: it is proposed that using virtual reality as part of therapy will result in improvements in post traumatic stress disorder for service members with ptsd related to service in iraq and/or afghanistan.

in the treatment development phase, participants will be enrolled in virtual reality therapy. the therapy will be based on principals of exposure therapy, but will also incorporate aspects of physiological monitoring, and cognitive restructuring. the therapy will be modified as indicated by clinical feedback, with a fixed protocol to be developed (with length of treatment and exact methods to be used to be determined). after a fixed protocol is agreed upon, the project will enter the randomized phase. in this portion, subjects will be randomly assigned to receive either the virtual reality treatment, or sent back to a waiting list during which time they will receive usual treatment. participants will be assessed to determine which treatment (vr or treatment as usual) results in the greatest improvements in ptsd, as measured by independent assessors using the clinician administered ptsd scale.

Eligibility criteria:
inclusion criteria: * diagnosed with post traumatic stress disorder related to military service in iraq or afghanistan by a military medical provider. willing and able to give informed consent to participate willing to give up intoxicating substances on the days of therapy exclusion criteria: * actively suicidal, homicidal, psychotic, or having a diagnosis of alcohol dependence that does not show signs of at least early remission

Keywords: virtual reality post traumatic stress disorder combat military major depressive disorder anxiety virtual reality exposure with stimulus control treatment as usual
the feasibility of telehealth hep for cp (hep: home exercise program), (cp: cerebral palsy)

Conditions: Cerebral Palsy, Spastic; Telemedicine

Summary: this study will provide exercise videos and live consultation sessions for adolescents with spastic cerebral palsy. we will recruit 20 participants with 10-18 years old and will be randomized into an experimental or control group. the experimental group will receive exercises videos 2 times a week and one time live consultation session for 8 weeks. the control group will receive exercise videos 3 times a week for 8 weeks. both groups will use hipaa compliant telehealth provider (physitrack website/ app).


Eligibility criteria:
inclusion criteria: * must be diagnosed with spastic cp diagnosis, gross motor functional classification system (gmfcs) levels i-iii) which will be confirmed by gmfcs-extended revised. * between the ages of 11 and 18 years old. * having a stable health status for 6 weeks prior to screening. * having the cognitive ability to follow an exercise instruction in either written or electronic format, with or without support from their parents. * with an approval from parents/guardians for participating in this study. * having access to the internet at home and access to the exercise's website/app via personal computer (pc), laptop, or mobile app. * being able to understand and follow verbal commands in english. the intervention and the questionnaires are available in english only. exclusion criteria: subjects will be excluded if they have: * unstable medical condition during past 6 weeks, * had other neurological disorders that may cause further decline in balance and walking abilities (head injury, vestibular dysfunction, or spinal cord injury), * or any musculoskeletal condition that would interfere with the safe performance of the exercise intervention or testing protocol, * scheduled surgical operations or castings during study period, * scheduled for intensive rehabilitation during 8 weeks of intervention.