Kornimate/medical-research-clean huggingface dataset:
the effects of profoveate on reducing self-stimulating behaviors

Conditions: Autism Spectrum Disorders; Normal Hearing; Normal Intelligence; Exhibit Self- Stimulating or Ritualistic Behaviors

Summary: this study is designed to pilot an intervention technique to reduce the self-stimulating behaviors seen in individuals with autism spectrum disorders using intervention with profoveate pellets. self-stimulating behaviors like hand flapping, eye blinking, and rocking, can interfere with the individual's ability to interact with their peers. participants will wear the pellets for four week and measures with taken again. another group of participants will not get the pellets. both groups will be tested at the beginning and end of the study. any variations in self-stimulating behaviors will be documented through parent report, observational data. the investigators hypothesize that they will see changes in self- stimulating behaviors as a result of the strategic placement of the profoveate™ pellets on the ears of one group of the participants.


Eligibility criteria:
inclusion criteria: * have a documented diagnosis of high functioning autism spectrum disorders (autism, asperger's syndrome, or pervasive development disorder (pdd) as reported by specialists who use the established criteria (american psychiatric association,2000) * pass a hearing screening at 25 decibels for the frequencies 1000, 2000 and 4000 hertz * score 85 or above on the test of nonverbal intelligence- 4 (toni-4; brown, sherbenou \& johnsen, 2009) * exhibit noticeable self- stimulating or ritualistic behaviors (i.e., scratching, hand flapping, eye blinks, etc.) and/or visual characteristics of autism spectrum disorder (asd) (sensitivity to light, visual fixations, poor eye contact, etc.) as reported by parents and/or observed on videos taken during assessment. exclusion criteria: * known history of latex allergy * intelligence score below 85 * fail the hearing screening

Keywords: autism self-stimulating behaviors autism spectrum disorders
establishment of a cohort of patients with sepsis-associated encephalopathy (sae)

Conditions: Sepsis-Associated Encephalopathy

Summary: in this study, the researcher involved the sepsis patients(defined by sepsis 3.0) in peking union medical college hospital. the sae was defined as the glasgow coma scale (gcs) score of less than 15 and the non-sae group gcs = 15. the control group was the non-infectious patients with acute disease strikes and the healthy control. after the sample collection, the rna-sequence, metabolites and cytokines were under detection.

we conducted a prospective observational cohort study of critically ill patients admitted to emergency department at a tertiary care hospital. this clinical study was approved by the ethics institutional review board of peking union medical college hospital. we identified the sepsis patients according to the sepsis 3.0 criteria. the sae was defined as the glasgow coma scale (gcs) score of less than 15 and the non-sae group gcs = 15. the control group was the non-infectious patients with acute disease strikes and the healthy control. we are collecting the samples of the included participants, including whole blood, plasma, serum, cerebrospinal fluid, stool and rectal swabs. the total rna was extracted from the whole blood by paxgene blood rna mdx kit (preanalytix) for rna sequence. we used the ultra-high performance liquid chromatography-ms/ms (uhplc-ms/ms) analysis for detected metabolites. we used the bio-plex 200 system (luminex corporation, austin, tx, usa) and simoa hd-x analyzertm (quanterix) platform to detect cytokines.

Eligibility criteria:
inclusion criteria: 1. sepsis 3.0 diagnostic criteria; 2. estimated length of hospital stay\> 24h; 3. ages 18-89; 4. acute brain dysfunction: delirium, coma, epilepsy, focal neurological deficit; 5. patients who meet the non-infectious sirs diagnostic criteria exclusion criteria: 1. diagnosis of patients with brain injury before admission, including alzheimer's disease, craniocerebral injury, etc .; 2. primary brain injury (cerebral hemorrhage, cerebral infarction, etc.), secondary brain injury (liver brain, lung brain, uremia encephalopathy, pancreatic encephalopathy, metabolic encephalopathy, wake encephalopathy, etc.); 3. pregnant and lactating women; 4. those who have undergone bypass surgery in the past 3 months; 5. hearing and vision impairment; 6. mental illness and melanoma; 7. abnormal coagulation, active bleeding 8. patients with infection at lumbar puncture site 9. meningeal leukemia patients 10. patients with other types of encephalopathy

Keywords: sepsis-associated encephalopathy
home-based massage by caregivers for dementia

Conditions: Dementia; Massage; Burden

Summary: the purpose of this study is to investigate the effects of manual massage on improving behavioral and psychological symptoms of dementia and sense of burden among caregivers.

a total of 40 patients with dementia and their family caregivers will be included and randomly allocated to experiment (n=20) or control group (n=20). the experiment and control group will receive whole body manual massage and placebo intervention (30 minutes once per week for 8 continuous weeks), respectively.

Eligibility criteria:
inclusion criteria: * over 65 years old, diagnosed with dementia, agitation or depression, irregular massage and exercise habits. exclusion criteria: * those who have open wounds, inflammation, infection, burns and scalds, artificial blood vessels in the hands, or diagnosed as inappropriate for massage in the near future, the severity of symptoms affects the study participants.
3d placental volume in placenta accreta

Conditions: Placenta Accreta

Summary: placenta accreta spectrum is a major obstetric disease nowadays. different methods are used for antenatal diagnosis. in our study, investigators are aiming to compare 2 common ways for diagnosis, i.e; 3d ultrasound and 2d with color doppler.

the word placenta accreta spectrum disorders (pasd) implies an atypical implantation of the placenta into the uterine wall and has been used to express placenta accreta, increta and percreta. placenta accreta is a placenta where the placental villi sick on directly to the myometrium. placenta increta is a placenta where the placental villi attack into the myometrium and placenta percreta is a placenta where the villi invade through the myometrium and into serosa. no antenatal diagnostic method gives the clinician 100% assurance of either ruling in or ruling out the existence of placenta accreta. the definitive diagnosis of placental accreta spectrum is frequently ended postpartum on hysterectomy specimens when an area of accretion shows chorionic villi which make direct contact with the myometrium and absence of deciduae. antenatal ultrasound is the method of choice used to establish the diagnosis and direct clinical management.the combined use of power doppler with three dimensional (3d) ultrasound provides the possibility of quantifying moving blood within a volume of interest. three indices are calculated, namely vascularization index (vi), flow index and vascularization flow index

Eligibility criteria:
inclusion criteria: * pregnant women with placenta previa exclusion criteria: * congenital anomalies of placenta placental separation uterine anomalies
evaluation inhaled corticosteroids on exhaled nitric oxide gas exchange

Conditions: COPD

Summary: to evaluate the role of inhaled corticosteroids to suppress nitric oxide gas exchange in stable patients with moderate-to-severe copd who are current non-smokers and not on oral corticosteroids.

stable, non-smoking copd patients not on oral corticosteroids will be randomized in single blinded study to evaluate nitric oxide gas exchange at baseline, and subsequent effects of fluticasone 100mcg/salmeterol 50mcg bid, and fluticasone 250mcg/salmeterol 50mcg bid. primary end points will include measurements of nitric oxide at varying expiratory flow rates to calculate bronchial, and small airway/alveolar nitric oxide. secondary end points will evaluate lung function. exhaled nitric oxide production presumably reflects endogenous inflammation. normal healthy, non-smoking controls will be used for comparison, with exhaled nitric oxide measured before and after 3 weeks of low dose inhlaed corticosteroids.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of copd * current non-smoker * not on oral corticosteroids * must be able to use advair discus or salmeterol discus exclusion criteria: * pregnancy * current smoker * on corticosteroids * clinically unstable

Keywords: chronic airflow obstruction
magnesium and platelet function testing

Conditions: Eclampsia Preeclampsia

Summary: magnesium has built up the reputation of a 'natural calcium antagonist'. however, the exact effect of magnesium on coagulation and more specifically on platelet function is still disputed. an important discrepancy between in vivo and in vitro studies exists. magnesium has thus been reported to antagonize platelets in some studies, and to stimulate platelets in other studies. current evidence seems to point in the direction of a general antagonization of aggregation and coagulation. intravenous magnesium is often administered in pre-eclampsia as seizure prophylaxis. therapeutic regimens usually consist of an intravenously administered loading dose (2-3 grams) and a maintenance infusion, targeting a plasma level of 2-3 mmol/l. therapeutic drug monitoring is needed, as magnesium toxicity is an important concern.


Eligibility criteria:
inclusion criteria: * signed informed consent * over 18 years of age (and younger or equal to 50 years of age) and able to provide legally binding consent * american society of anesthesiologists physical fitness scale 1 (non smoker, no or minimal alcohol use, ..) exclusion criteria: * chronic disease * chronic medical therapy (other than oral contraception) * pregnancy * asa 2 or higher * known coagulation or aggregation disorders * use of cox-inhibitors in the last 10 days * contra-indications for venipuncture
hyperpolarized carbon-13 imaging of metastatic prostate cancer

Conditions: Prostate Cancer

Summary: a pilot study with a group of up to 10 men with crpc about to embark on a 6-month course of treatment with radium 223. study participants will undergo anatomical mr imaging combined with the new hyperpolarized mri (1 hour exam) prior to treatment.

"hyperpolarization" of low natural abundance species such as 13c, offers the potential of extracting metabolic information by real-time imaging of biochemical reactions within the body. in this project, the investigators focus on prostate cancer, specifically late-stage disease, as management of these patients would benefit from a new imaging method that enables improved therapy selection, planning and monitoring. for imaging the lactate distribution in bone-metastatic prostate cancer, 3d coverage of a large field-of-view is required in order to cover the vertebral column (the most common site of metastases). to enable this, the investigators have developed methods using a large-volume transmitter and multi-channel receiver system for 3-dimensional 13c metabolic imaging in these patients. the image resolution and encoding matrix were tailored to the required 3d coverage of the vertebral column. at the end of this study, the investigators will have the methodology, hardware and clinical-research workflow needed to evaluate 13c-lactate imaging as a new tool to help patients with metastatic prostate cancer. the investigators would be the first in the world to apply 13c metabolic mri to bone metastases. although the investigators propose to study patients who are starting a 6-month course of treatment with radium 223, in this project, this proof-of-concept study may also lead to a larger clinical trial at different points in the treatment pathway, such as prior to deciding between treatment with cytotoxic agents versus drugs that target the androgen axis such as abiraterone.

Eligibility criteria:
inclusion criteria: * men with bone-metastatic crpc before starting the first dose of radium 223 therapy * laboratory requirements: * absolute neutrophil count (anc) ≥ 1.5 x 109/l * platelet count ≥ 100 x109/l * hemoglobin ≥ 10.0 g/dl (100 g/l; 6.2 mmol/l) * total bilirubin level ≤ 1.5 institutional upper limit of normal (uln) * asat and alat ≤ 2.5 uln * • creatinine ≤ 1.5 uln * albumin \>25 g/l * eastern cooperative oncology group status of 0 or 1 exclusion criteria: * unable to give valid informed consent * contraindication for mri as per sunnybrook mri questionnaire (appendix 1). * claustrophobia * body mass index of less than 18.5 or greater than 32 * congestive heart failure, a past or present medical history of clinically significant electrocardiogram (ekg) abnormalities, which may include qt prolongation, a family history of prolonged qt interval syndrome, or a myocardial infarction (mi) within the past 12 months with ensuing unstable ekg, or ongoing acute or chronic pulmonary bronchospastic disease, including a history of chronic obstructive pulmonary disease or asthma, with an exacerbation within the past year
thoracic interfascial plane block versus thoracic paravertebral block in gynecomastia surgery

Conditions: Gynecomastia; Thoracic Interfascial Plane Block; Thoracic Paravertebral Block; Anesthesia

Summary: the growing increase in the number of gynecomastia surgeries has resulted in an increased need for anesthetic techniques with improved pain reduction, safety, and fewer complications. the aim of this work is to compare the efficacy of ultrasound guided thoracic interfascial plane block and ultrasound guided thoracic paravertebral block for anesthesia in gynecomastia surgery.

this prospective randomized open label clinical trial will be carried out on 90 male patients undergoing elective idiopathic gynecomastia surgery in tanta university hospitals. study design: patients will be randomly allocated into three equal groups by computer generated sequence through sealed opaque envelopes: group c: 30 patients will receive bilateral tumescent local anesthesia as a control group. group tpvb: 30 patients will receive bilateral us guided thoracic paravertebral block. group tipb: 30 patients will receive bilateral us guided thoracic interfascial plane block.

Eligibility criteria:
inclusion criteria: * aged ≥ 18 up to 65 years * male gender only * asa physical status i and ii * weight 75-100 kg * duration of surgery ≤ 2 hours * scheduled for elective idiopathic gynecomastia surgery exclusion criteria: * patient refusal. * uncooperative patients. * known hypersensitivity to local anesthetic (la) (bupivacaine). * local infection at the site of injection (tpvb or tipb). * coagulopathy. * history of opioid abuse or chronic analgesic use.
inf-α innate immune response to gliadin

Conditions: Celiac Disease

Summary: background \& aims the enteropathy in celiac disease (cd) is due the adaptive and to the innate immune response to gliadin peptides. gliadin peptide p31-43 activates innate immune response and interferes with vesicular trafficking. type 1 interferons (infs) and viral infections play a role in cd pathogenesis. in this paper investigators investigated the role of p31-43 in the activation of the inf-α pathway. methods small intestinal biopsies of cd patients both with active disease on gluten containing diet (gcd) and in remission phase of the disease on a gluten free diet (gfd) and controls were analyzed before and after culture with p31-43. the levels of toll like receptor 7 (tlr7), myeloid differentiation primary response 88 (myd88), myxovirus resistance protein 1 (mxa) and nuclear factor-κb (nf-κb) proteins and inf-α mrna was analyzed in intestinal biopsies.

intestinal biopsies from cd patients and controls were obtained after egds performed during routine analysis. the biopsies were immediately immersed in culture medium (dulbecco's modified medium, dmem) in a falcon tube and kept for 16h at 37 c before cultivation. biopsies were cultivated as described in barone mv1, caputo i, ribecco mt, maglio m, marzari r, sblattero d, troncone r, auricchio s, esposito c. humoral immune response to tissue transglutaminase is related to epithelial cell proliferation in celiac disease. gastroenterology. 2007,132(4):1245-53.

Eligibility criteria:
inclusion criteria: biopsy fragments from duodenum were obtained from cd patients with villous atrophy on gcd, controls, affected by gastroesophageal reflux, and cd patients on gfd. exclusion criteria: other inflammatory intestinal diseases

Keywords: celiac disease; p31-43; loxorubine; tlr7.
effectivity of motor imagery and mirrortherapy in amputees

Conditions: Amputees

Summary: this study evaluates the effectiveness of imagery motor on phantom pain and amputation process

the expected increase in the number of amputations in the coming decades requires special attention to the common effect after called phantom limb amputation. that term refers to the phenomena covering the sensations that occur in the affected limb and whose prevalence rate is an important part of amputees subjects. developed theories about their origin focus their attention on the central nervous system and the peripheral nervous system. thus, the imaginary movement is a complex cognitive, sensory and proprioceptive process leading to a mental representation of movement and it is a widely used technique in neurological rehabilitation and complex pain syndrome.

Eligibility criteria:
inclusion criteria: 1. pain in the stump area ≥ 3 months, no intermittent 2. have three months elapsed amputation, 3. submit subjective sensation of phantom limb not blinking exclusion criteria: * clinical signs of radiculopathy. * lumbar stenosis, fibromyalgia, spondylolisthesis. * history of spinal surgery. * corticosteroid therapy in the past two weeks. * disease of the central nervous system or peripheral.

Keywords: motor control laterality pain perception lower extremity complementary therapies physical therapy modalities
study of ibrutinib and rituximab in treatment naïve follicular lymphoma

Conditions: Follicular Lymphoma

Summary: the purpose of this study is to evaluate whether the addition of ibrutinib will result in prolongation of progression-free survival (pfs) when compared with rituximab alone in treatment naïve participants with follicular lymphoma.


Eligibility criteria:
inclusion criteria: * histologically confirmed diagnosis of follicular lymphoma cd20+ (grade 1, 2 or 3a) ann arbor stage ii, iii or iv disease. * measurable disease * subjects 70 years of age or older; or subjects 60-69 years of age who have one or more comorbidities. * meets one or more groupe d'etude des lymphomes folliculaire (gelf) criteria. * adequate hematologic function within protocol-defined parameters. * adequate hepatic and renal function within protocol-defined parameters. * ecog performance status score of 0-2. exclusion criteria: * transformed lymphoma * prior treatment for follicular lymphoma. * central nervous system lymphoma or leptomeningeal disease. * currently active, clinically significant cardiovascular disease.
development and pathological changes of high myopia among children and adolescents in china

Conditions: High Myopia

Summary: the study aims to observe the relationship between the changes of ocular structure parameters and pathological changes among children and adolescents with high myopia. environmental factors and family history will also be collected to explore their impacts on high myopia progression.

this study aims to observe children and adolescents with high myopia for 3 years, and to collect data of ocular pathological changes, family history and environmental factors so as to understand the natural course and internal laws of the development of high myopia.

Eligibility criteria:
inclusion criteria: * 9 to 18 years old school students in guangzhou, with either eye had myopia equal or greater than 6.0d * or 6 to 8 years old school students in guangzhou, with either eye had myopia equal or greater than 3.0d * written informed consent for study participation * be willing to cooperate with the relevant ophthalmological examination and complete the questionnaire. exclusion criteria: * none school students in guangzhou * other contraindications * a history of allergy to tropicamide or topical anesthetics * missing ability to give informed consent

Keywords: high myopia ocular biometric parameters adolescent children
detection of risk behaviors: pilot observational study with bedridden and agitated patients.

Conditions: Risk Behavior; Agitation; Hospitalization; Bedridden Patients

Summary: there is a risk of falls and injuries in bedridden hospitalized patients, increased in agitated or confused patients. in neurosurgery departments, brain damaged patients can present a loss of consciousness of risky behaviors and be in a state of agitation which frequently leads to their endangerment. the repercussions of this endangerment are multiple. for the patients, there may be a feeling of insecurity, with physical or chemical restraint solutions which deprive them of their freedom without a total guarantee of safety. for the caregivers, there is an emotional distress in front of this endangerment, and a professional guilt. finally, there are economic repercussions due to the costs of complementary examinations and the lengthening of hospitalization. the objective of the present study is to determine the nature and frequency of occurrence of risk behaviours, through the observation of bedridden and agitated hospitalized patients. these risk behaviours are defined as potentially dangerous and are warning signs for the caregiver. a better understanding of these behaviours could help to better anticipate falls and injuries and to implement preventive measures more quickly.


Eligibility criteria:
inclusion criteria: * hospitalized in the neurosurgery department of the clermont-ferrand university hospital * suffering from neurological and/or cognitive disorders leading to agitation and/or confusion * affiliation to a social security system * hospitalization in the department for at least 9 days * acceptance by the patient and/or trusted person capable of giving informed consent to participate in the research exclusion criteria: * acute or transient agitation phase of somatic origin (bladder globe, pain, ionic disorder...) * patient under guardianship, curatorship or safeguard of justice * pregnant and breastfeeding women * refusal to participate