Kornimate/medical-research-clean huggingface dataset:
changes induced by early habit-ile in pre-school children with uni- and bilateral cerebral palsy

Conditions: Cerebral Palsy

Summary: studying in two randomized controlled trials (rct) the changes induced by early habit-ile in functional, neuroplastic and biomechanical assessment in children with unilateral and bilateral cp.

this study aims to evaluate the effect of two weeks of early hand-arm bimanual intensive therapy including lower extremities (habit-ile) on bimanual performance in pre-school children with unilateral cerebral palsy (cp) and on gross motor function in those with bilateral cp, compared with two weeks of usual motor activity including usual rehabilitation (control group). we will assess further changes in unilateral performance tests, daily life activities questionnaires and executive function tests. neuroplastic changes will be assessed using brain imaging (magnetic resonance imaging, mri) and biomechanical changes will be assessed by using optoelectronic motion capture system with electromyography (emg), to determine the effect of habit-ile on movement pattern and quality.

Eligibility criteria:
inclusion criteria: * children with unilateral or bilateral cerebral palsy (spastic or dyskinetic) * age 1 to 4 years inclusive (corrected age if preterm birth) * ability to follow instructions and complete testing according to the age. exclusion criteria: * active seizure * programmed botulinum toxin or orthopedic surgery in the 6 months previous to the intervention, during intervention period or 3months after the intervention time * severe visual impairments * severe cognitive impairments * contraindications to perform mri assessments (metal implants, etc.)

Keywords: motor skill learning functional changes neuroplastic changes biomechanical changes
the effect of trendelenburg lithotomy position on pain and procedural time during vaginoscopic office hysteroscopy

Conditions: Uterine Diseases

Summary: the present study revealed that the tl position is supposed to be more efficient not only for lowering pain score but also reducing the procedural time. also, performing hysteroscopy in this position may be easier for doctors than in the lithotomy position.

voh is a widely used diagnostic method and seems to be getting more into outpatient clinics. despite its huge contribution to clinical practice, pain during the procedure is an important limiting factor. we aimed to investigate the effect of the trendelenburg lithotomy position to the pain and procedural time.however, there is a scarcity of research on this subject. therefore, the rationale of the study was to enlighten the gap in the literature regarding the pain score and procedural time during voh for diagnostic purposes in tl position. in order to gain scientific evidence, a randomized controlled trial was conducted to compare pain score and duration of procedure between the standard lithotomy position and tl position. also, the convenience for the physician performing the procedure was assessed. to the best of our knowledge, this is the first study in the literature investigating the effect of the position of the patient during the procedure on both time, pain, and the convenience for the physician simultaneously.

Eligibility criteria:
inclusion criteria: * uterine disorders * abnormal uterine bleeding * infertility exclusion criteria: * pregnancy * cervical disorders * pelvic infections

Keywords: vaginoscopic office hysteroscopy lithotomy position trendelenburg lithotomy position visual pain score procedural time likert scale
early versus delayed cholecystectomy

Conditions: Acute Cholecystitis

Summary: this study examines complications, mortality rates, cost-effectiveness and safety of early laparoscopic cholecystectomy (elc) versus delayed laparoscopic cholecystectomy (dlc). group l (n:88) patients treated surgically with laparoscopic cholecystectomy immediately or group d (n:88) patients first treated medically and than treated surgically with delayed (4-8 weeks later) laparoscopic cholecystectomy.

there is only few knowledge about the comparison of early laparoscopic cholecystectomy (elc) versus delayed laparoscopic cholecystectomy (dlc) for the treatment of acute cholecystitis considering the surgeon's work experience. this study examines complications, mortality rates, cost-effectiveness and safety of dlc versus elc. this prospective randomized clinical trial was performed between november 2015-2016 in our general surgery clinic. patients suffering acute cholecystitis in their first 72 hours of pain were enrolled in one of the two study groups: group l (n:88) patients treated surgically with laparoscopic cholecystectomy immediately or group d (n:88) patients first treated medically and than treated surgically with delayed (4-8 weeks later) laparoscopic cholecystectomy. all operations and medical treatments were done by surgeons having work experience \<2 years.

Eligibility criteria:
inclusion criteria: * patients suffering acute cholecystitis in their first 72 hours of pain exclusion criteria: * clinical duration longer than 72 hours, complicated acute cholecystitis (bilirubin \>2gr/dl, elevated transaminases (\>100 u/l), and cholestatic enzymes (gamma glutamyl transferase \>50 u/l), ultrasonographically confirmed dilated intrahepatic or extrahepatic bile ducts, and elevated amylase levels three times more than normal range

Keywords: laparoscopic cholecystectomy, delayed cholecystectomy
clinical trial on harmonic focus shears versus ligasure small jaw and clamp-and-tie technique for total thyroidectomy

Conditions: Benign Thoroid Disease Requiring Total Thyroidectomy

Summary: the harmonic focus and ligasure small-jaw are the last device designed for thyroid surgery. the aim is to assess: 1. decrease of operative time (minutes); 2. decrease of post-operative blood loss (milliliters); 3. decrease of post-operative stay (days); decrease of post-operative complications (%, hypocalcemia, laringeal nerve demage), compared to traditional dissection in a prospective randomized trial of total thyroidectomy procedures, for benign disease.

a single-blinded prospective randomized controlled trial was conducted at a tertiary referral center. a total of 120 patients who required a thyroidectomy for thyroid benign disease, will be randomized to either harmonic focus or ligasure small-jaw or clamp-and-tie technique during thyroidectomy. the operative time (minutes), morbidity rate (%), post-operative blood loss (milliliters), hospital stay (days), post-operative hypocalcemia (%), and cost of thyroidectomy (euros) were compared between the three groups.

Eligibility criteria:
inclusion criteria: * thyroid benign disease exclusion criteria: * malignant disease * thyroid malign disease requiring lymphadenectomy * coagulatory disease
evaluating the performance of morphology index in surgical decision-making for ovarian tumors

Conditions: Ovarian Neoplasms

Summary: the present investigation will prospectively evaluate whether serial transvaginal ultrasonography with morphology index (mi) can further reduce false positive results by more accurately distinguishing benign from malignant ovarian tumors. if there is no change in the detection of true positive cases, the result will be an increase in the positive predictive value of ovarian cancer screening.

primary objective: to determine if a treatment algorithm using serial transvaginal ultrasound with a tumor morphology index can improve the positive predictive value (ppv) of ovarian cancer screening compared to a historical control from 15% to 25%. secondary objective to measure the compliance for study participants enrolled on the treatment algorithm using serial transvaginal ultrasound with a tumor morphology index. exploratory objective to determine the effectiveness of a treatment algorithm that combines serum biomarkers aloneor in combination with transvaginal ultrasound to reduce the false positive rate of ovarian cancer screening in the subset of women agreeing to biomarker collection.

Eligibility criteria:
inclusion criteria: * women must be enrolled in the university of kentucky ovarian cancer screening program eligibility criteria for the ocsp are: 50 years of age or older, or be postmenopausal and have not had a prior salpingo-oophorectomy or have a family history of ovarian cancer in a primary relative or have a self-history of breast cancer. * patients have a documented ovarian abnormality on ultrasound * patients having undergone prior hysterectomy will be eligible provided that they meet the other requirements for entry into this study. * ability to understand and the willingness to sign a written informed consent document exclusion criteria: * patients who are not enrolled in the university of kentucky ovarian cancer screening program . * patients who cannot tolerate the vaginal ultrasound procedure. * uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * patients who are referred with pelvic symptoms, a known pelvic mass, or a history of prior radiation, will be excluded from this investigation. * history of ovarian cancer. * prior bilateral salpingo-oophorectomy. * prisoners. * women who are currently pregnant.

Keywords: ovary cancer morphology surgery
telehealth interventions for cardiac surgery

Conditions: Cardiac Valve Disease; Coronary Artery Disease; Surgical Complication

Summary: the goal of this clinical trial is to compare telehealth monitoring at home against usual care in patients undergoing planned heart surgery. the main questions it aims to answer are: 1. can telehealth improve quality of life prior to surgery 2. can telehealth prevent serious deterioration requiring hospital or primary care attendance participants awaiting heart surgery will be randomly allocated to either telehealth remote monitoring of symptoms, blood pressure, heart rate, oxygen levels and activity levels or they will be allocated to usual care which is unmonitored on the waiting list for surgery. researchers will compare telehealth to usual care to see if it improves quality of life or prevents deteriorations on the waiting list.

patients on elective cardiac surgery waiting lists can deteriorate, presenting via acute services as urgent inpatients as a result of their decompensation and facing increased surgical risk. with increases in waiting times prevalent through the country, and healthcare resources under pressure from covid-related backlogs, it is imperative to find ways to monitor and escalate the most vulnerable patients and to provide safe methods of providing healthcare interventions outside conventional hospital settings. remote monitoring identifies patients at need, and allows tertiary-care led interventions to prevent deterioration in the first instance. such facilities could also enhance recovery following treatment and reduce the risks of complications and readmissions post-operatively. the benefits and risks of such programmes is, however, not well understood: additional monitoring may increase the burden of responsibility on patients or monitoring facilities without providing additional safeguards to the patient. the advantages of early detection may not translate into improved outcomes and the onus on the patient to report in may reduce quality of life rather than enhance it. the researchers therefore seek to identify if telehealth monitoring can improve health related quality of life, reduce unplanned admissions and healthcare resource utilisation and enhance pre-habilitation using protocolised patient engagement facilities to reduce complications and improve risk-stratification metrics such as smoking status, diabetic control and bmi.

Eligibility criteria:
inclusion criteria: 1. adult patients over 18y referred and accepted for cardiac surgery 2. able to consent to participate exclusion criteria: 1. urgent or emergent surgery 2. surgery planned within 3 weeks of first cardiac surgery outpatient review

Keywords: telehealth remote monitoring waiting list quality of life
clinical research on teratment of gastrointestinal cancer in the preoperative by propranolol

Conditions: Gastrointestinal Cancer

Summary: to research the effect of propranolol on the proliferation and apoptosis of gastrointestinal cancer.


Eligibility criteria:
inclusion criteria: 1. patients with gastric adenocarcinoma and colon cancer were diagnosed by histology and cytology, and there was a clear metastasis (txnxm0); 2. without any prior treatment (including surgery or radiotherapy and chemotherapy) in the i-iii period, no distant metastasis, suitable for patients with surgical resection of the tumor. 3. the age range of the patients is 18-60; 4. systolic pressure 100-140mmhg; heart rate \>60bpm; 5. the patient's survival time should be longer than 3 months; 6. without previous cardiovascular and cerebrovascular diseases, the atrioventricular block was excluded by the 24 hour dynamic electrocardiogram; 7. ecog score of 2 (that means the patient's bed time is less than 50%); karnofsky score of 60% (that means patients have the basic activities and self-care ability); 8. the basic biochemical examination results of patients with normal: white blood cell 3000/ul; neutrophil 1500/ul 100000/ul; platelet count; total bilirubin \< 1.5 x uln; ast / alt 2.5 x uln without liver metastasis; \< 5 x uln liver metastasis; creatinine clearance rate of 1.5 x uln; 9. have the ability to understand and sign informed consent. exclusion criteria: 1. pregnant or lactating women; 2. patients with severe heart disease, kidney disease, metabolic disorders, bronchial asthma, cardiogenic shock, heart block (ii-iii degree atrioventricular block), or severe acute heart failure, sinus bradycardia. 3. patients with epilepsy or psychotropic drugs and sedatives; 4. patients with brain metastasis and bone marrow metastasis; 5. participants in clinical trials of other drugs within 4 weeks; 6. patients with a history of anaphylaxis with propranolol; 7. patients treated with trastuzumab; 8. patients with or reactive immunodeficiency, such as those with hiv infection; 9. the uncontrollable situation in the group during the period (but not limited to these cases): according to the experimental scheme of medication, severe infection, due to mental illness or other social factors lead to the compliance requirements of patients; 10. patients with atrioventricular block should be discontinued immediately and quit; 11. the researchers believe there may be any increase in the risk of the subject or any interference with clinical trials.

Keywords: gastrointestinal cancer propranolol
cardiovascular magnetic resonance in adults with systemic right ventricle (star)

Conditions: Transposition of Great Arteries

Summary: the main aim of the study is to explore hfs in srv, comparing their magnitude and direction with that of subpulmonary rv and systemic lv. as a secondary aim, possible association or correlation will be investigated between srv energetics and: i) patient functional parameters, e.g., the results from cardiopulmonary exercise test (cpet), ii) patient clinical status, including the occurrence of adverse outcome (a composite of death, hospitalization for heart failure, cardiovascular arrest, sustained arrhythmias).


Eligibility criteria:
inclusion criteria:case group: the study will include patients aged ≥ 18 years with the diagnosis of l-tga and d-tga, who: * are admitted to unicca, the adult congenital heart unit or * are scheduled for a cardiovascular magnetic resonance examination in this institution control group: the study will include subjects aged ≥ 18 years who will invited for a cardiovascular magnetic resonance examination in our institution. this group of control will include n=15 of adult healthy subjects. a further inclusion criteria for the control subjects are age and male proportion comparable to those of the tga group. exclusion criteria: * (case and control group) * subjects with intrabody ferromagnetic material precluding subject's safety * subjects with non cmr-conditional devices * subjects with claustrophobia or breath-holding precluding an adequate cmr and 4d flow images quality * pregnant women
interleaving stimulation improves dyskinesia in parkinson's disease

Conditions: Parkinson's Disease

Summary: this study is designed as a prospective, randomized, double-blind, controlled study to assess putative differences in the effect of interleaving stimulation and empirical stimulation with regards to post-operation dyskinesia control. the primary objective is to assess putative differences in the effect of interleaving stimulation and empirical stimulation with regards to dyskinesia control.

this study is designed as a prospective, randomized, double-blind, controlled study to assess putative differences in the effect of interleaving stimulation and empirical stimulation with regards to post-operation dyskinesia control. the primary objective is to assess putative differences in the effect of interleaving stimulation and empirical stimulation with regards to dyskinesia control. 50 patients will be randomly assigned to either the interleaving stimulation modes group (isg) or the empirical stimulation modes group (esg). in isg, empirical stimulation for the first 3 months, followed by interleaving programming period for 6 months, and any stimulation decided by the neurologists/neurosurgeons for the final 3 months. in esg, empirical programming for the first 9 months' period, followed by any stimulation decided by the neurologists/neurosurgeons for the final 3 months. the change of dyskinesia scores (updrs iv, item 32 + item 33), parkinson's disease quality of life-39 (pdq-39) scores, scores of united parkinson's disease rating scale part iii as well as scores of neuropsychological battery in interleaving stimulation compared to empirical programming modes will be measured based on corresponding time frame. finally, the results will be analyzed via proper statistical methods and thus the conclusion will be drawn.

Eligibility criteria:
inclusion criteria: * 1. patients at the age of 30-65 years old. 2. patients diagnosed as parkinson's disease according to the uk parkinson's disease society brain bank criteria. 3. patients at hoehn and yahr stage 3 or lower in the on-state and stage 2 - 4 in the off-state. 4. the disease duration of 5 years or more. 5. patients with deep levodopa-responsive parkinson's disease, and are not adequately controlled by drug therapy. exclusion criteria: * major illness or medical comorbidities, depression that is untreated but judged to be clinically significant by an investigator, cochlear implants, cardiac pacemakers, needs for diathermy, anticoagulant therapy, previous neuro-surgical procedure or ablative therapy, frank dementia according to cognitive screening, drug or alcohol abuse, being a woman of child-bearing potential, having a positive pregnancy test, or presence of a terminal illness.

Keywords: interleaving stimulation dyskinesia syndrome in in parkinson's disease randomized, double-blind, controlled trial
open-label study of omega 3 oil supplementation for aging-related cognitive decline

Conditions: Cognitive Decline

Summary: aging-related cognitive decline may be affected by brain cholesterol and the health of cell membranes. certain nutritional supplements have been proposed to support membrane health, and there is increasing interest in plasmalogens and omega-3 derived oil supplements to support brain health among older adults. the product being investigated in this study is the prodromeneuro omega 3 oil nutritional supplement. this product contains naturally occurring fatty acids in higher concentrations than similar products that are commercially available. the purpose of this research study is to better understand the effects of prodromeneuro omega-3 nutritional supplementation among subjects with age-related cognitive decline.

there has been an increasing interest in plasmalogens as a potential therapeutic agent for age-related cognitive decline and neurodegenerative conditions, given the growing understanding of their involvement in key cellular functions as well as the clinical trends observed when plasmalogen levels are depleted. in addition to supporting the structural integrity of membranes, these plasmalogens are also involved in a variety of critically important cell functions: membrane fusion, ion transport, vesicle formation, and oxidation-reduction. plasmalogen and serum plasmalogen deficiency has been shown to impair cellular functions, particularly related to cholesterol processing, and has been implicated in alzheimer's and other diseases. plasmalogen precursor supplementation has been demonstrated as safe and potentially efficacious in preclinical studies and some patient populations. in theory, prodromeneuro supplementation may yield therapeutic benefits among patients with age-related cognitive decline by increasing levels of neuroprotective plasmalogens. the present study is being undertaken as an open-label study to evaluate the safety and tolerability of prodromeneuro omega-3 oil as an intervention for patients with age-related cognitive decline. baseline and outcome measures in this study utilize validated tests that are appropriate for repeated measures. neurocognitive assessment and serology testing kits to evaluate for plasmalogen levels will also be administered at baseline, end of the first month, end of the second month, end of the 3 month, and after one month post treatment termination.

Eligibility criteria:
inclusion criteria: * cognitive decline due to aging-related changes * clinical dementia rating stage of mild dementia 0.5 through moderate dementia cdr stages 1 and 2 exclusion criteria: * subjects unable to give informed consent * cognitive decline clearly related to an acute illness * subjects taking anticoagulants and anti-platelet agents * advanced terminal illness * any active cancer or chemotherapy * any other neoplastic illness or illness characterized by neovascularity

Keywords: aging
an evaluation of exercise tolerance in asthmatic patients

Conditions: To Evaluate

Summary: to evaluate exercise tolerance.


Eligibility criteria:
inclusion criteria: - 40-50 years exclusion criteria: * no excerbations

Keywords: asthma