Kornimate/medical-research-clean huggingface dataset:
genetic polymorphisms in ugt1a6 and ugt2b7 in asian population: association with lung cancer phenotype

Conditions: Lung Cancer

Summary: primary 1. to determine the presence and frequency of novel and known ugt1a6 and ugt2b7 polymorphisms in healthy chinese, malay and indian subjects. 2. to determine the presence and frequency of novel and known ugt1a6 and ugt2b7 polymorphisms in chinese lung cancer patients with squamous cell and adenocarcinoma subtype. 3. to analyze the functional variations in ugt1a6 and ugt2b7 polymorphisms. secondary 1 to study the correlation of ugt1a6 and ugt2b7 polymorphisms with lung cancer type.

germline polymorphisms are inherited genetic variation present in all cells of the body. at molecular level, such variations may affect gene transcription, translation, mrna stability, protein activity, protein expression (1-3). mounting evidences have emerged showing that genetic polymorphisms in drug metabolizing genes and dna repaired genes are major determinants of response to drugs and carcinogens with possible predictive or prognostic value for clinical outcome (4-6). however, only a small number of all polymorphisms discovered have functional significance and it is often difficult to predict this base on nucleotide sequence alone. genome based studies have generated a wealth of data on genetic polymorphisms far exceeds our knowledge on the function of these variants. hence, there is an urgent need to characterize the functional and expressional impact of genetic polymorphisms in candidate genes so that appropriate target polymorphisms most likely to affect the phenotype can be selected for larger scale association studies. in this study, we will adopt a novel 2-stage approach to identify and characterize new polymorphisms in the ugt1a6 and 2b7 genes in our asian population. data from our initial genotyping work will then be used to optimize the study design of the stage ii association study for the generation of hypothesis that lung cancer histology (phenotype) is associated with ugt polymorphisms (genotype). this study will help to advance our understanding in the functional significance and diversity of genetic variants that exist in our population. it may also shed light on the role of ugt in carcinogenesis and will provide vital ground work for future studies of risk assessment, treatment and may allow identification of at risk individual for chemoprevention and adjuvant therapy studies.

Eligibility criteria:
inclusion criteria for stage i study * subjects \>= 18 years old * hemoglobin \>= 8g/dl, total white cell counts \>3.0 x 103/μl * ecog =0 inclusion criteria for stage ii study * chinese ethnicity * patients \>18 years old * hemoglobin =\> 8g/dl, total white cell counts \>3.0 x 103/μl * histologically or cytologically confirmed lung cancer for stage ii study * uncontrolled medical conditions such as diabetes, hypertension and coronary artery disease. exclusion criteria * histology of small cell lung cancer * medical or psychiatric conditions which may impair the patient's ability to provide informed consent.
non-surgical periodontal treatment with adjunctive use of lactoferrin contained in toothpaste and mouthwash

Conditions: Periodontal Diseases

Summary: the aim of the study is to assess the effect of lactoferrin in lbc complex can be effective in reducing periodontal clinical parameters in a 6-month study on pregnant patients.

the aim of the study is to assess the effect of lactoferrin in lbc complex can be effective in reducing periodontal clinical parameters in a 6-month study on pregnant patients. patients' enrollment will be conducted according to inclusion criteria. at the first visit, periodontal parameters will be recorded: plaque index (pi), recession (r) bleeding on probing (bop), modified marginal gingival index (mmgi), papillary marginal gingival (pmgi), plaque control record ( pcr %), approximal plaque index (api), clinical attachment loss (cal) and probing pocket depth (ppd). professional debridement will be conducted with piezoelectric instrumentation and air-flow administration with glycine powders. subsequently, patients will be randomly divided into two groups: - the trial group, in which patients will perform home oral hygiene with emoform glic toothpaste + mouthwash twice a day the control group, in which patients will perform home oral hygiene with emoform glic toothpaste twice a day. professional debridement will be repeated every 3 months. periodontal indexes evaluation will be conducted at the baseline (t0), after 1 month (t1), after 3 months (t2), and after 6 months (t3).

Eligibility criteria:
inclusion criteria: * women at the 4th month of pregnancy exclusion criteria: * presence of cardiac pacemaker * neurological and psychiatric diseases * patients taking bisphosphonates during the previous 12 months from the - beginning of the study * patients undergoing anticancer therapy. * patients with poor compliance.

Keywords: pregnant patients
consultation-liaison intervention for patients with depression and anxiety in primary care

Conditions: Depression; Anxiety

Summary: the colipri study is a cluster randomized controlled trial funded by the swiss national science foundation to evaluate the clinical and cost effectiveness as well as the implementation of a complex consultation-liaison intervention to help improve symptoms of anxiety and depression of screened patients in primary care. the intervention includes expert consultations, on demand referral for structured mental health diagnostics, psychoeducation and treatment planning, as well as brief psychotherapeutic interventions and triage.

mental disorders such as depression or anxiety are serious and common health conditions that are highly prevalent in primary care. the primary care sector plays a key role in the treatment of common mental disorders as general practitioners (gps) set the course for identification, diagnosis, therapy and referral to specialized treatment. the objectives of the colipri study are to implement a complex consultation-liaison service at the intersection between primary and secondary care and to investigate its clinical and cost effectiveness in patients who are identified at primary care practices with elevated symptoms of depression and anxiety. focus of the complex intervention is on improved collaboration and communication among gps, mental health experts, and other services involved in the care of patients with common mental disorders. the novel service aims to support the decision-process at primary care practices, to increase access to evidence-based mental health treatment, and to help improve patients' pathways of care. the colipri service for gps include expert consultations, on-demand patient referral for structured diagnostics, and/or treatment planning, as well as brief psychotherapeutic interventions and triage. the effectiveness and cost effectiveness of the intervention as an add-on to enhanced usual primary care (usual care plus structured depression and anxiety screening) are evaluated in a cluster randomized clinical trial in screened patients with at least mild symptoms of depression and/or anxiety. in case of positive results, the service might serve as a model how to improve multi professional collaboration and clinical resource allocation for better delivery of mental health care.

Eligibility criteria:
inclusion criteria: * patients scoring ≥5 on the phq-9 and/or scoring ≥5 on the gad-7 * presenting and treated at the participating practice * sufficient command of the german language * individual signed informed consent exclusion criteria: * acute suicidality at the time of enrolment according to clinical evaluation * a history of psychotic symptoms * bipolar disorder type-i or type-ii * acute substance-related and addictive disorder (i.e. as primary diagnosis) * severe cognitive impairment or other serious factors causing inability to follow the procedures of the study

Keywords: primary mental care collaborative care health services research common mental disorders implementation disease management
computed tomography dose reduction using sequential or fast pitch sprial technique

Conditions: Coronary Artery Disease; Aortic Aneurysm; Pulmonary Embolism

Summary: this is a prospective, controlled observational trial of patients undergoing clinically indicated cardiothoracic computed tomography (ct), including pulmonary or aortic angiography and coronary ct angiography (ccta).

the development of a novel ct scanner capable of sequential or fast-pitch spiral techniques in most patients (siemens definition flash) represents a potentially crucial technical innovation at a particularly critical juncture. national healthcare systems are under pressure to deliver accurate and cost-effective diagnosis of an increasing number of patients and ct angiography in various settings is a proven, highly accurate technique that has been shown to improve diagnostic efficiency and reduce the cost of care. however, there has been increasing concern about the lifetime attributable risk of cancer from radiation related to diagnostic procedures. such concern extends to other radiation-based procedures that contribute to the cumulative lifetime radiation exposure of patients. the flash scanner holds the promise of substantially reducing exposure resulting from a variety of examinations. the ct dose multicenter trial is therefore designed to validate the extent of dose reduction attendant to the use of the flash scanner in cardiothoracic scanning, and to determine whether image quality is preserved in spite of significant dose reduction.

Eligibility criteria:
inclusion criteria: * scans from patients undergoing clinically indicated pulmonary angiography, aortography and/or ccta. * age greater than or equal to 18 years. exclusion criteria: * no exclusions

Keywords: coronary artery disease ct scan coronary angiography chest pain aortic aneurysm pulmonary embolism
imaging whole coronary artery with intravascular ultrasound (ivus) and imap for plaque tissue composition in patients with acute myocardial infarction

Conditions: Acute Coronary Syndrome

Summary: the iwonder trial has the following objective: to analyze the morphological, phenotypic and tissue characteristics of atherosclerotic plaques angiographically considered "culprit" and "not-culprit" in patients undergoing coronary angiography due to stemi (st-elevation myocardial infarction).

coronary artery angiography (ca) is a two-dimensional silhouette of the arterial lumen from a complex three dimensional vascular structure. this exam has several limitations already well documented, including shortening of the vessel, overlapping images, intra and inter-observer variability during the consideration of the severity of injuries. besides, it offers great limitations in the diagnosis of the composition of atherosclerotic plaque. furthermore, intravascular ultrasound (ivus) provides a sensitive and reproducible measure of the dimensions of the vessel and allows direct visualization of the vessel wall, atherosclerotic plaque and arterial lumen. the utility of grayscale ivus as prognostic tool and as a guide in percutaneous coronary interventions (pci) is well established. more recently, ivus has also provided new insights for safety and efficacy of drug eluting stent (des). advances in technology now allow ivus to characterize the morphology and composition of plaques. specifically, the analysis of the ivus wave frequency - beyond the interpretation of wave lengths used in grayscale ivus- enables in vivo analysis of atherosclerotic plaque composition with high sensitivity and specificity. although previous studies have reported data using ivus radiofrequency analysis, the use of a new modality (imaptm, boston scientific, santa clara, ca, usa) for characterization of atherosclerotic plaque is poorly known.

Eligibility criteria:
inclusion criteria: * age \< 75 years * diagnosis of nstemi/stemi with prior use of fibrinolytics in the past 7 days * signature of the term of informed consent exclusion criteria: * hemodynamic instability * clinical signs of post-ami ventricular dysfunction (killip iii/iv) * angiographic findings of (1)coronary anatomy with significant tortuosity, (2) critical coronary obstruction preventing the passage of the ivus catheter and (3) total occlusion of any of the three epicardial coronary arteries.

Keywords: ivus imap catheterization acute coronary syndrome
the effects of plantar stimulation on hypotension, treatment efficacy and quality of life with adults on hemodialysis

Conditions: Hypotension

Summary: for the end stage renal disease (esrd) patients undergoing hemodialysis treatment, specifically, reflex mediated calf muscle pump stimulation has the potential to significantly reduce the number and magnitude of hypotensive episodes thus enhancing the effectiveness of the dialysis process. fewer hemodialysis complications during the patient's hemodialysis treatment, would allow treatment sessions to continue to the prescribed volume removal, with much reduced patient recovery time, and the costs associated with this recovery.

recruit individuals who consistently miss their dialysis goal. maintain the goal over a six week period of time. utilize exogenous calf muscle pump stimulation during each dialysis session to enhance fluid return from the lower limbs with the objective of assisting the patient in reaching ultrafiltration goal. track number of hypotensive events during dialysis, as well as goal success.

Eligibility criteria:
inclusion criteria: 1. 18 years of age or older; 2. alert and oriented to time, place, and self; 3. able to read and speak the english language; 4. currently receiving hemodialysis treatment approximately 3-4 hour sessions, 3 times a week; 5. received hemodialysis treatments continuously for the several previous months; and 6. consistently exhibits hypotensive symptoms during dialysis. exclusion criteria: 1. receiving hemodialysis as a temporary treatment following a peritoneal dialysis complication or an episode of transplant rejection; 2. receiving hemodialysis at home; or 3. if they have a medical history of any the following conditions: deep venous thrombosis, uncontrolled hypertension, pulmonary embolus

Keywords: hemodialysis treatment pump stimulation reduce hypotensive episodes
use of bone scintigraphy, ct and mri in breast cancer

Conditions: Breast Neoplasms

Summary: a new imaging modality combining ct and tomographic bone scintigraphy (spect/ct) has enabled the combination of functional and anatomical imaging. its use in cancer patients has not yet been evaluated or validated against a relative gold stand or clinical follow up. the purposes of this study are: 1: to validate the use of conventional planar bone scintigraphy and spect combined with low-dose or diagnostic ct and compare this to 3 tesla mri and clinical follow up. 2: to compare the specificity of low-dose and diagnostic ct, respectively, combined with bone spect. 3: to construct an algorithm for optimal evaluation of disease dissemination in breast cancer patients


Eligibility criteria:
inclusion criteria: * histological verified breast cancer * age 18-80 years * investigation for metastases using imaging modality/modalities planned * written consent to participate in trial exclusion criteria: * overweight limiting the use of mri * metal parts in body * claustrophobia * allergy to contrast agents used in trial * pregnancy

Keywords: spect/ct mri breast neoplasms
the effects of dietary salt on post-exercise hypotension

Conditions: Blood Pressure; Post-Exercise Hypotension

Summary: the new american heart association (aha) blood pressure guidelines are expected to raise the prevalence of high blood pressure to \~46% in the united states. one recommendation for lowering blood pressure is aerobic exercise, which produces a period of lowered blood pressure (post-exercise hypotension; peh) that lasts up to 24 hours. it is believed that peh may be responsible for the observations of lowered blood pressure following initiation of exercise. however, most americans eat too much salt, which expands plasma volume and may prevent peh, rending aerobic exercise ineffective in improving blood pressure status.

recently released blood pressure guidelines from the american heart association and american college of cardiology are expected to raise the prevalence of hypertension in america from \~33% to \~46%. a single bout of aerobic exercise produces a prolonged period (up to 24 hours) of lowered blood pressure (post-exercise hypotension; peh). repeated bouts of aerobic exercise results in maintenance of lowered blood pressure, leading to recommendations of aerobic exercise for improvement of blood pressure status. however, more than 90% of americans consume more sodium in their diets than is recommended. this is alarming, as excess dietary sodium intake expands plasma fluid volume, which may in turn attenuate the reduction in bp following exercise. therefore, the objective of this project is to determine the effects of high dietary sodium intake on peh. the investigators hypothesize that, compared to a recommended sodium diet, a high salt diet will attenuate post-exercise hypotension.

Eligibility criteria:
inclusion criteria: * recreationally active exclusion criteria: * high blood pressure (\>140/90 mmhg) * history of cardiovascular disease * history of cancer * history of diabetes * history of kidney disease * obesity (bmi \> 30 kg/m2) * smoking or tobacco use * current pregnancy * nursing mothers * communication barriers
mis hematoma evacuation

Conditions: Intracranial Hematoma

Summary: the primary objective of this study is to determine the effectiveness of the nico brainpath™ hematoma evacuation system for patients between the ages of 18 and 80 years old with an intracerebral hematoma. effectiveness will be defined as the ability to achieve either 70% reduction of intracranial hematoma or to achieve \<15 ml residual hematoma volume following surgery. additionally, the study aims to compare the mortality and complication rate of patients who undergo minimally invasive, navigation guided endoport based evacuation of intracerebral hematoma with nico brainpath™ system as compared to non-operative, supportive standard of care. the study is a prospective, non-randomized cohort study. 50 patients will be enrolled in group a (nico brainpath™ system) and 50 patients will be matched retrospectively of similar diagnosis, undergoing standard of care from epic). 50 patients will undergo minimally invasive, navigation guided endport based evacuation of intracerebral hematoma with nico brainpath™ system. the patient population receiving non-operative supportive care will be matched to the surgical patients based on age, gender, and location of hemorrhage.

approximately 100 patients will participate in this study. patients with significant intraparenchymal hemorrhage who are admitted under the neurology service in the neurocritical care and medical icu will be screened for eligibility. a repeat ct scan 6 hours after stabilization to show that there has been no increase in size of the ich will determine eligibility in the trial. patients that meet eligibility criteria after this ct will be taken to the or within 24-72 hours for a minimally invasive, navigation guided endoport based evacuation of the clot using the nico brainpath™ system. at baseline, the glasgow coma scale (gcs) and the modified rankin score (mrs) will be captured, along with baseline demographics. the gcs and mrs will be recorded at 1-, 3, and 6-month post-operatively. a follow-up ct will be captured at 3 months. mortality and adverse events will be reviewed at each timepoint.

Eligibility criteria:
inclusion criteria: 1. 18 and 80 years of age, inclusive 2. spontaneous supratentorial, intracerebral hematoma ich \>30 ml measured by the abc/2 method. 3. location of hemorrhage: lobar, putaminal and/or caudate 4. a glasgow coma scale (gcs) of 4 or greater 5. historical modified rankin score (mrs) of 0 (no symptoms of neurological disability) or 1 (no significant disability despite symptoms, able to carry out usual duties and activities). exclusion criteria: 1. pupils dilated and fixed 2. rapidly deteriorating patient (at the discretion of the surgeon) 3. primary thalamic bleed 4. intraventricular blood (more than 50 % of either ventricle, visual estimate) 5. ich secondary to aneurysm 6. arteriovenous malformation (avm) 7. tumor 8. moya-moya 9. sinus thrombosis 10. platelet count \ 1.4 11. known coagulopathy, on anticoagulants that cannot be reversed
fistula reintegration pilot

Conditions: Female Genital Fistula; Urinary Incontinence

Summary: this is a pilot study to test the feasibility and acceptability of a multi-component facility-based intervention designed to be provided adjunct to genital fistula surgery incorporating: health education, psychosocial counseling, physiotherapy, and economic investment. we will include a total of 30 women in the study, and follow them for 6-months using a mixed-methods strategy for feasibility and acceptability assessment.


Eligibility criteria:
inclusion criteria: * undergoing surgery for female genital fistula * age 18 or above, or emancipated minor per ugandan law exclusion criteria: * no further criteria
impact of hibiscus on cardiovascular disease risk

Conditions: Cardiovascular Diseases

Summary: hibiscus sabdariffa calyces (hsc) extract is consumed in different parts of the world as a cold or hot drink and is available in the united kingdom (uk) markets in different forms including tea bags. there is preliminary data that support the hypothesis that hsc extract consumption has beneficial effect on blood vessel health and blood pressure reduction. hypertension, vascular dysfunction, inflammation and lipid abnormalities are all key modifiable risk factors of cardiovascular diseases (cvd), the leading causes of death throughout the world. in the phytovas (phytochemicals and vascular function) study the effect of the acute consumption a potentially bioactive food extracts: hibiscus sabdariffa calyces (hsc) compared with a matched control (water) on blood pressure and blood vessels function will be investigated after a high - fat mixed meal. this is with a view to determining the impacts of the extract on postprandial (after meal) blood pressure and other cvd risk factors. results from the phytovas study could lead to identification of more dietary approaches that will contribute to cvd risk prevention and management.


Eligibility criteria:
inclusion criteria: * male * 30 - 65 years * 1 to 10 % cardiovascular disease risk in 10 years * not taking blood pressure medication * not having liver or kidney disease * not anaemic * a signed consent form exclusion criteria: * female * \ 65 years * \ 10 % cardiovascular disease risk in 10 years * taking blood pressure medication * having liver or kidney disease * anaemic * lack of signing consent form * vegan * individual with food allergy * sufferers of chronic illness

Keywords: hibiscus sabdariffa calyces blood pressure vascular function inflammation cardiometabolic risk markers systemic antioxidant capacity