Kornimate/medical-research-clean huggingface dataset:
international observational study on airway management in critically ill patients

Conditions: Critical Illness; Respiratory Failure; Hemodynamic Instability; Coma

Summary: endotracheal intubation (eti) is a potentially life-threatening procedure for critically ill patients and major severe complications such as severe hypoxia, cardiovascular collapse and cardiac arrest are common. despite the high risk of the procedure, different interventions lack high-quality evidence and the investigators hypothesize that a heterogeneous practice among different centres and geographical areas may be found. the investigators designed a large international observational study aiming at prospectively collecting data on the current impact of eti-related adverse events and current airway management practice in critically ill patients. investigators will collect data on all consecutive in-hospital (intensive care unit, emergency department and wards) etis performed in adult critically patients.

this study aims at prospectively collecting data on the current morbidity and mortality of eti-related adverse events and current airway management practice in adult critically ill patients. investigators designed a large international study calling for participation all institutions caring critically ill patients worldwide. inclusion criteria investigators will include all adult (≥ 18 years old) critically ill patients undergoing intubation during the period of observation. investigators will consider all in-hospital intubations. critically ill will be defined those patients with a life-threatening condition requiring intubation for either cardiorespiratory failure or airway protection. exclusion criteria * intubation performed in the out-of-hospital setting * intubation during cardiac arrest * intubation performed for anaesthesia primary outcome major eti-related adverse events - composite outcome (severe hypoxemia, cardiac arrest and cardiovascular collapse - see further for definitions) secondary outcomes minor eti-related adverse events and icu mortality (see further for definitions). sample size investigators' aim is to collect data from 1000 intubation- related major complications. from a previously published report (jaber 2006) the expected incidence of at least one major complication is 28%. therefore investigators plan to recruit data from 3600 endotracheal intubations. intubation rate may vary from 0.5 to 2 etis/day according to different centres (e.g. total hospital beds, number of icus and icu beds) and local policies. each centre will be asked to collect data from 20 etis. a maximum time window of 8 weeks will be allowed for each centre (i.e. for centres with a slower recruitment rate, data collection will stop after 8 weeks irrespective of total number of etis collected data). investigators plan to recruit at least 180 centres worldwide.

Eligibility criteria:
inclusion criteria: * critically ill patients undergoing in-hospital endotracheal intubation. exclusion criteria: * intubation performed in the out-of-hospital setting; * intubation during cardiac arrest; * intubation performed only for anaesthesia.

Keywords: airway management
randomized trial comparing alfuzosin gits 10 mg daily with placebo for trial without catheter in acute urinary retention with long term follow up

Conditions: Prostatic Hyperplasia; Urinary Retention; Acute Disease

Summary: the purpose of the study is to compare alfuzosin gits once daily versus placebo in achieving a successful twoc after aur due to bph, among chinese males in hong kong, and in delaying or avoiding a turp.


Eligibility criteria:
inclusion criteria: * aged 50 or above * admitted for aur due to bph with pvr of 500 ml or more exclusion criteria: * previous history of turp * use of alpha blockers within recent 8 months * renal impairment (serum creatinine \>140 umol/l) * poor premorbid state

Keywords: benign prostatic hyperplasia (bph) acute retention of urine (aur)
internet assisted obesity treatment

Conditions: Overweight; Obesity

Summary: high quality behavioral weight loss programs are not widely accessible. the internet offers one way to deliver health behavior programs to a wider audience. however, effective weight loss treatments are intensive and program delivery over the internet may not be capable of duplicating the level of engagement typically generated during traditional in-person treatment. the goal of this study is to test the effectiveness of three weight loss interventions: internet alone, internet+periodic in-person support, and in-person alone. the investigators hypothesize that the in-person and internet+in-person interventions will produce better weight loss and maintenance than the internet only group.

currently 65% of the adult population is overweight or obese. unfortunately, safe and effective treatments for obesity are costly and intensive; therefore, this level of support is unlikely to be feasible in most clinical settings. moreover, an additional limitation to current obesity treatment approaches is the limited reach and availability of programs for persons who work, live in rural areas or do not want, or cannot afford participation in group support classes. the advent of telecommunications technology may provide a solution to this dilemma. telecommunications technology can presumably improve access to services and improve efficiency of delivery. moreover, research examining new technologies such as the internet, will provide information for policy makers interested in disseminating low-cost, high reach effective obesity treatment interventions. however, the effectiveness of the internet for inducing weight loss has not been rigorously tested. therefore, the overall goal of this project is to determine if obesity treatment can be effectively delivered over the internet. a secondary aim is to evaluate whether the effectiveness of internet interventions can be improved with the addition of minimal in-person support. specifically, this project is a randomized, controlled clinical trial designed to test the translation of a behavioral weight loss program to the internet (i). the i intervention will be compared to both an in-person condition (ip) and an internet condition supplemented with periodic in-person support (i+ip). subjects will be 488 (30% minority) overweight and obese adults recruited from vermont and arkansas who will participate in a 6-month behavioral weight control treatment program followed by 12 months of weight maintenance. assessments will include measures of body weight, adherence to treatment goals, social influence components and frequency of use of internet website features.

Eligibility criteria:
inclusion criteria: * \>18 years old * bmi\>25 * internet access exclusion criteria: * pregnancy * major medical problems * inability to walk for exercise
effect of feeding frequency on glucose and insulin metabolism and substrate partitioning in impaired glucose tolerant (igt) men

Conditions: Glucose Intolerance

Summary: the purpose of this study is to determine the effect of feeding frequency on glucose and insulin metabolism and substrate partitioning in impaired glucose tolerant (igt) men.


Eligibility criteria:
inclusion criteria: * bmi: 20-35 kg/m2 * gender: male * age: subjects has to be older than 18 and younger than 70 years old * impaired glucose tolerant (igt) = plasma glucose, two hours after consuming 75g glucose, appears to be superior to 7.8mmol/l (normal level) but remains inferior to 11.1mmol/l (diabetes level) and fasting plasma glucose is less than 7.0mmol/l. * caucasian exclusion criteria: 1. lactose intolerant 2. diabetes mellitus 3. cardiovascular diseases 4. stomach and intestinal diseases 5. normal glucose levels after 2 hours 6. anticoagulants 7. medication that has a effect on energy and glucose homeostasis and absorption of foods 8. conditions or situations when subjects can't lose 500 ml blood

Keywords: insulin metabolism glucose metabolism substrate partitioning muscle biopsies feeding frequency insulin
a prognostic model based on pocus at icu admission in critically ill patients with sepsis

Conditions: Sepsis

Summary: sepsis is responsible for one in three patient deaths. understanding the severity of the disease, directing medications, prognosticating, and communicating with family members depend on the ability to predict outcomes in a patient presenting with sepsis in the icu. the outcome of mortality reflects the caliber of icu treatment. this is a prospective observational study that will include all patients diagnosed with sepsis for point-of-care ultrasonography within 24 hours of admission to the icu from april 26, 2023, to march 30, 2024, and create a model that will predict 28 day outcome in these patients.


Eligibility criteria:
inclusion criteria: * age \>=16 yrs within 24 hour of icu admission diagnosed as sepsis as per sepsis 3 exclusion criteria: * usg cannot be done within 24 hour of admission to icu if usg cannot be done for 2 parameters who do not give consent withdrawal of active life support do not intubate(dni) or do not resuscitate(dnr) order at admission
lumbar transforaminal epidural dexamethasone

Conditions: Radicular; Neuropathic, Lumbar, Lumbosacral

Summary: the aim of this study is to assess the effectiveness and safety of dexamethasone for transforaminal epidural steroid injection. a secondary aim of this study is to obtain data on the lowest most effective dose of dexamethasone for this treatment and the effective duration of effect.

transforaminal epidural steroid injections (tfesi) have been demonstrated to be an effective treatment for radicular pain. over the last decade, rare but serious complications have been reported following transforaminal epidural steroid injections (tfesi). recent research indicates that certain types of corticosteroids containing microscopic particles may be responsible for these adverse events. dexamethasone (dxm) is a non-particulate cortico-steroid that has not been implicated in these adverse events. however, there is inadequate evidence up to date to support the use of dexamethasone (dxm) for transforaminal epidural steroid injections (tfesi). this study aims to bridge that gap.

Eligibility criteria:
inclusion criteria: * adults age 18 years and older, unilateral lumbar radicular pain, baseline distal radicular lower extremity pain vas score ≥ 5/10, and prior favorable response to tfesi exclusion criteria: * pregnancy, infection, coagulopathy, uncontrolled diabetes mellitus, history of allergy to iodinated contrast medium and interventional therapies for pain within 90 days prior to study enrollment

Keywords: epidural, transforaminal, steroid injection, dexamethasone
effects of arts engagement on physical performance, cognition, social isolation, and self-perception in older adults

Conditions: Social Isolation; Mental Status Change; Cognitive Impairment; Physical Activity; Quality of Life; Self-Perception

Summary: the purpose of this community-engaged project is to examine how taking part in different arts (dance \& music), compared to control (no arts) affects older adults' health-related quality of life (hrqol using the short form-20(sf) form), physical performance (short physical performance battery-sppb), cognition (using the montreal cognitive assessment-moca), social engagement (national social life, health, \& aging project-nshap survey), and perceptions of self (focus interviews).

in this randomized-controlled-trial, 60 adults (20/condition) will take part in 20, 45-minute sessions (ballroom dance, ukulele/guitar playing, or control- i.e. social conversation), 2 times/week for 10 weeks. while the investigators know that arts participation improves function in older adults, exact effects of different arts programs on health outcomes remains unclear. the investigators plan to fill this gap by studying how different arts participation affect health outcomes. the overall aim is to study how arts engagement helps older adults remain active and influences physical, psychological, and emotional functioning.

Eligibility criteria:
inclusion criteria: * be healthy, * \> 65 years of age and able to take part in learning music, or ballroom dance. exclusion criteria: * presence of a co-morbid mental health diagnosis or other physical or behavioral challenges that the study staff assess as rendering the participant unable or unsafe to participate in the study.

Keywords: dance music social conversation
assignment of alcohol drinks to cidi drink categories

Conditions: Alcohol Drinking

Summary: alcohol consumption is a prevalent behavior in western societies, which may produce feelings of happiness and sociability, but also increases the risk of individual and societal detriments. a detailed knowledge about individual and region-specific alcohol consumption is crucial in many aspects of health systems, from general practitioner's diagnostic evaluation to decisions on health-care related fundings for prevention programs by legislative and executive councils. the assessment of alcohol consumption often consists of questions like "what alcohol and in which amount did you drink lately?" which may be answered using a given list of prevalent alcoholic beverages. with this study, the investigators want to contribute to the understanding of psychological determinants in answering these questions. for example, it is not yet fully understood, to which extend and why certain beverages are assigned to one of several beverage groups. the investigators suspect that familiarity with specific beverages as well as product names may influence this assignment. in this online survey, which is open to any german-speaking alcohol user no matter how often or how much alcohol one normally consumes, participants will be presented a list of common beverages (e.g. cuba libre, prosecco, weizen) and asked to assign these beverages to one of several beverage groups (e.g. whiskey, beer, sparkling wine).

the investigators expect that alcohol users will assign alcoholic drinks based on the product names, which might lead to erroneous assignments to predefined drink groups in certain occasions (e.g. "bierlikör - beer liquor"). furthermore, it is hypothesized that this tendency is smaller the more familiar a user is with the drink. lastly, it is hypothesized that drinks with relatively low use prevalence in the general population, e.g. sweet liquors and cocktails, and drinks that include alcohol mixed with non-alcoholic beverages (e.g. "radler", a beer-lemonade mix), are more often subject to non-concordant assignment across participants compared to highly-prevalent drinks (e.g. "pilsner"). thus, the investigators expect alcohol users to: 1. assign \>90% of the presented beverages correctly, 2. differ from the expert assignments especially in drinks they are not familiar with, 3. differ from the expert assignments especially in drinks with ambiguous names, 4. do not differ in their assignments based on their gender and age group.

Eligibility criteria:
inclusion criteria: * lifetime-consumption of any of the 60 presented alcoholic beverages, * consumption of 12 or more alcoholic drinks past year, * ability to understand and accept the informed consent, to answer the presented questions and fill out all questionnaires exclusion criteria: * multiple participation in this study * not answering at least one presented questionnaire (60-beverages-questionnaire, assignment-questionnaire, audit questionnaire, sociodemographic questionnaire)

Keywords: alcohol use consumption measure composite international diagnostic interview (cidi) internet survey standardized assessment
covid-19 infection in diabetic patients

Conditions: Covid19; Diabete Type 2; Non Diabetic Patients; Chest CT Scan

Summary: it was observed during the last period of covid-19 pandemic that diabetic patients had a worse prognosis and more deteriorated clinical features than other patients

diabetic patients infected with sar-cov-19 were reported to have worse prognosis and faster deterioration in addition to higher rate for icu admission when compared to other infected patients. in this study authors aim to investigate the certain cause for their case deterioration to be modified for better prognosis

Eligibility criteria:
inclusion criteria: patients infected with covid-19 male or female 30 years old or more inpatients exclusion criteria: * have othe comorbidities other than type 2 diabetes mellitus pregnant women below 30 years old

Keywords: covid-19 prognosis mortality rate diabetes mellitus
treatment of recent onset low back pain with periradicular injections of meloxicam

Conditions: Low Back Pain

Summary: this randomized, double-blind, placebo control, cross-over study tested the hypothesis that periradicular injections of meloxicam would reduce recent onset low back pain and improve physical activity compared to saline injection at 3 months follow-up evaluation

in the present study we use a well-known non steroidal anti-inflammatory drug, meloxicam, in a novel way, an im administration near a nerve root.

Eligibility criteria:
inclusion criteria: * low back pain from 6 months or less * older than 18 years exclusion criteria: * not able to understand and sign the written informed consent
assessment in work productivity and the relationship with cognitive symptoms in patients with mdd taking vortioxetine

Conditions: Major Depressive Disorder

Summary: the purpose of the study is to describe the association/correlation between change in patient-reported cognitive symptoms and work productivity in gainfully employed patients receiving vortioxetine for a major depressive episode (mde).

this is an interventional, canadian, multi-site, open-label, single cohort, flexible-dose study. the study will emulate a naturalistic real-life setting. investigators will include primary care physicians and psychiatrists working in outpatient clinics. the study will include adult patients diagnosed with mdd according to the dsm-5™. approximately 200 patients will be enrolled in the study. there will be approximately 100 patients who receive vortioxetine as a first treatment for the current mde and 100 patients switched to vortioxetine due to inadequate response to their current antidepressant medication treatment. all patients will be treated with vortioxetine as per the product monograph, and at the doses determined appropriate by the investigator. the total study duration from baseline to the end of follow-up will be approximately 56 weeks.

Eligibility criteria:
inclusion criteria: * the patient is a man or woman, aged ≥18 years and \<65 years (in the province of british columbia, the patient must be aged 19 years or older in order to give informed consent) * the patient is engaged in volunteer work or gainful employment (working ≥20 hours per week) or is enrolled full-time in post-secondary studies or vocational training. * the patient is an outpatient consulting a primary care physician or a psychiatrist. * patients must have a diagnosis of mdd according to the diagnostic and statistical manual of mental disorders, 5th edition (dsm-5™) classification code 296.3x. * the current mde is confirmed by the investigator. * the reported duration of the current mde is at least 3 months. * the patient has a baseline score ≥15 on the qids-sr. * the patient reports at least a minimal level of cognitive symptoms as defined by baseline score of ≥30 on the pdq-d-20. * the patient is capable of communicating with the site personnel and is able to conduct the digit-symbol substitution test (dsst). exclusion criteria: * the patient score is \>69 on the dsst at screening/baseline. * the patient is, in the opinion of the investigator, not able to complete all the study assessments including, but not limited to, patient-reported assessments and the dsst. * the patient has a current diagnosis or history of manic or hypomanic episode, schizophrenia or any other psychotic disorder, including major depression with psychotic features. * the current depressive symptoms are considered by the investigator to have been resistant to 2 adequate antidepressant treatments of at least 6 weeks duration each at the maximum recommended dose (according to canadian labeling). other protocol defined inclusion and exclusion criteria do apply.

Keywords: depression major depressive disorder cognition cognitive symptoms vortioxetine real life naturalistic
efficacy and safety of valsartan versus amlodipine in postmenopausal women with hypertension

Conditions: Hypertension

Summary: the purpose of this study is compare treatment with valsartan with the possible addition of a diuretic, hydrochlorothiazide, on high blood pressure with the drug amlodipine with the possible addition of a diuretic, hydrochlorothiazide. in particular, the effect of treatment on the stiffness of the blood vessels will be studied.


Eligibility criteria:
inclusion criteria: * postmenopausal women * mild to moderate hypertension * statin therapy or ldl≤ 4.1 mmol/l exclusion criteria: * severe hypertension * ldl \> 4.1 mmol/l if not taking anti-hyperlipidemic medication * certain hormonal therapy * history of stroke, myocardial infarction, heart failure, chest pain, abnormal heart rhythm * liver, kidney, or pancreas disease * diabetes * raynaud's disease or any other significant peripheral vascular disease * allergy to certain medications used to treat high blood pressure other protocol-defined inclusion/exclusion criteria may apply.

Keywords: hypertension postmenopausal valsartan amlodipine hydrochlorothiazide