Kornimate/medical-research-clean huggingface dataset:
clinical evaluation of verisee amd in screening for age-related macular degeneration

Conditions: Macular Degeneration, Age Related; Maculopathy, Age Related

Summary: an observational study is designed to evaluate the clinical performance of verisee amd for potential age-related macular degeneration (amd) screening from color fundus photography images. the sensitivity and specificity of verisee amd's automated image analysis for screening amd will be determined through the comparison with the gold standard, which is the judgment of amd by the ophthalmologists.

this is a retrospective, single-center, observational study to assess the clinical performance of verisee amd in screening for potential age-related macular degeneration (amd). potential subjects with images of color fundus photography will be selected for eligibility, and then the ophthalmologist further confirms the images with legible quality. three independent ophthalmologists (or evaluators) having more than 6 years of experience in retina will evaluate amd from the color fundus photography images with different sequences of images independently. these three evaluators are different from the ophthalmologist who is responsible for deciding subject's eligibility. the evaluators determine the severity of amd based on the four-level scale which is the amd severity scale stated in age-related eye disease study (areds) report no. 6. before the study, the training section is necessary to ensure the consensus of the amd severity grading among three evaluators. the severity determined by the majority of the grade the three evaluators gave is considered the gold/reference standard in this study. therefore, level 1 and level 2 are classified as non-mtl3amd, while level 3 and advanced amd (level 4) are classified as mtl3amd. the clinical performance displayed as sensitivity and specificity will be determined by comparing the amd results between verisee amd and the gold standard. verisee amd is intended to screen amd from the images taken by color fundus photography, which can assist the physicians to assess whether further examination for retinopathy by the ophthalmologist is needed. the screening result of amd will be non-mtl3amd or mtl3amd for the physicians' reference and does not intend to diagnose amd, detect concomitant diseases, or treat amd.

Eligibility criteria:
inclusion criteria: * subject with age ≥ 50 years old * subject with image taken by color fundus photography that meet the following requirement: 1. the resolution of image is 271x271 pixels or higher; 2. the angle view of image is 45 or 50 degree. * subject's image includes macula as judged by the ophthalmologist. exclusion criteria: * the color fundus photography image previously used by verisee amd during the development process and pre-clinical test * the macula or other part in the image of color fundus photography is unclear to determine the disease condition as judged by the ophthalmologist.
study assessing impact of dermatology consultation for patients admitted with cellulitis

Conditions: Cellulitis

Summary: this is a randomized, controlled study to compare patients evaluated and managed by internal medicine hospitalists alone versus patients who are additionally evaluated by a dermatologist when they are admitted to the hospital, aiming to demonstrate that hospital admissions for cellulitis that involve early dermatology consultation will reduce hospital length of stay, readmission rates, prevalence of pseudocellulitis, cost, and antibiotic usage. the hypothesis of this study is that obtaining inpatient dermatology consultations, within 24 hours of a patient being admitted to the hospital for cellulitis, will reduce the length of stay, readmission rate, cost, and antibiotic usage of the patient"s admission as well as properly evaluate and diagnose patients with pseudocellulitis. the primary objective will be to measure the difference in the length of stay for patients who are randomized to a dermatology consultation within 24 hours of hospital admission (active arm) versus being managed by an internal medicine hospitalist alone, as is the standard of care (control arm). the length of stay for each arm will be assessed once the study has been completed. the secondary endpoint will be to measure readmission rates for cellulitis after patients are discharged from the hospital. an additional endpoint will be to determine if antibiotic usage differs between patients randomized to a dermatology consultation and those not. exploratory analyses will assess the percentage of patients with a concomitant known predisposing factor for recurrent cellulitis such as lymphedema, leg ulceration, tinea pedis, or onychomycosis, as well as the association of fever \>100.5 f and a history of a prior episode of cellulitis.


Eligibility criteria:
inclusion criteria: * able to understand and sign informed consent * able to complete study and comply with study procedures * presumed clinical diagnosis of cellulitis by medicine team exclusion criteria: * have a known postoperative site infection or abscess * have a human/animal bite * have known osteomyelitis * have a hardware/line infection * are under the age of 18 * have a history of transplantation less than six months after initial transplant and/or if they have had an episode of acute rejection in the last 90 days * known use of antithymocyte globulin or campath in the last 6 months or more than 20 mg/day of prednisone for more than 30 days - * are a known prisoner. * are decisionally-impaired. * have abnormal vital signs defined as systolic blood pressure \ 100.5 f. * are known to be pregnant.
volume-challenge in morbid obesity

Conditions: Anomaly; Venous Return

Summary: preoperative venous return stability and euvolemia is essential in management of morbidly obese patients. fluid therapy regimes for patients with high bmi, especially with focus on preoperative management, are rare and not in consensus.the aim of this study was to evaluate preoperative effects of a standardized, ideal body weight (ibw) based volume-challenge on hemodynamics, stroke volume and level of venous return to the heart.

34 morbidly obese patients scheduled for bariatric surgery underwent a preoperative three-week preparation by rapid-weight-loss-diet (rwl) to be accepted for bariatric surgery. preoperative transthoracic echocardiography (tte) was performed in the awake state before and after volume-challenge (vc) based on 6ml colloids /kg ibw. feasibility of standardized vc was evaluated by tte. dynamic and non-dynamic echocardiographic indices for vc were studied. main outcome measures: volume-responsiveness and level of venous return before and after volume-challenge were assessed by tte. an increase of stroke volume ≥ 13% was considered as a volume-responder.

Eligibility criteria:
inclusion criteria: * enrolled for bariatric surgery * bmi ≥ 40 or ≥ 35kg/m2 with co-morbidities * preoperative three-weeks preparation by rapid-weight-loss-diet and weight loss exclusion criteria: * untreated significant hypertension * unstable angina pectoris * significant valve regurgitation or stenosis * known severe pulmonary disease

Keywords: morbidly obese patients, preoperative volume-challenge, transthoracic echocardiography, tte, rapid weight loss, venous return, bariatric surgery, left ventricular outflow tract, stroke volume, diastolic function, hypervolemia, hypovolemia
plasmatic concentrations of propofol and remifentanil in obese and non obese patients.

Conditions: General Anesthesia; Obesity

Summary: this prospective monocentric phamacokinetics study aims to compare plasmatic concentrations of propofol and remifentanil required to target a specific range of monitored anesthesia and analgesia during sus-mesocolic surgery in obese and non obese patients.

remifentanil and propofol are administered intravenously as an opioid pain reliever and hypnotic pain reliever during anesthesia. their advantages are numerous: short half-life allowing anesthesia and rapid awakening, little accumulation, allowing to adapt the level of anesthesia or sedation to each patient, few side effects. entropy° is an index derived from the electroencephalographic signal of patients, validated for the evaluation of the level of narcosis during general anesthesia. ani ° (nociception index analgesia) is an index using the ventilatory physiological variability of the sinus rhythm validated to monitor patient's analgesia during general anesthesia. these non-invasive means of analgesia and sedation monitoring allows the clinician to ensure satisfactory levels of anesthesia by administering products at minimum effective doses. the authors propose to determine whether, for a comparable target effect (analgesia and monitored sedation), plasmatic concentrations and administration rates of propofol and remifentanil necessary during general anesthesia for a comparable surgical stimulus are the same in populations of obese and non obese patients.

Eligibility criteria:
inclusion criteria: obese patients group: * age ≥ 18 years old * severe and morbidly obese patients (35kg / m2≤imc \<55kg / m2). * patients undergoing general anesthesia for laparoscopic susmesocolic surgery (bariatric surgery or cholecystectomy). * patients who have given their consent in the manner described by the public health law of august 9, 2004. * patients benefiting from a social security scheme. group of non-obese patients: * age ≥ 18 years old * patients with normal weight or slightly overweight (19 \<bmi \<30). * patients receiving general anesthesia for laparoscopic susmesocolic surgery (cholecystectomy). * patients who have given their consent in the manner described by the public health law of august 9, 2004. * patients benefiting from a social security scheme. exclusion criteria: * patient refusal * age \<18 years old * protected adults and vulnerable persons * pace maker * general anesthesia in the 24 hours preceding this surgery * proven or suspected dysautonomia * premedication by gabapentin neurontin ° * locoregional peri-medullary analgesia technique used concomitantly during the pre- and intraoperative period. * unbalanced dysrhythmic heart disease (ac / fa; extrasystoles; non-sinus rhythm) * pregnant or breastfeeding woman * intubation impossible planned * hypersensitivity to the products used * allergy to peanut or soy

Keywords: general anesthesia obesity propofol pharmacokinetic remifentanyl pharmacokinetic
effects of framing on medication beliefs, intentions to take medication, adherence, and asthma control

Conditions: Asthma

Summary: the goal of this study is to examine the effects of framed mobile messages on young adults' beliefs about their daily inhaled corticosteroids (ics), intentions to take their ics, adherence, and asthma control. college students (18-29 years) who owned a mobile phone and had a diagnosis of asthma with a prescription for an ics will be recruited. participants will be randomized to receive either gain- or loss-framed mobile messages three times per week for eight weeks. outcomes including beliefs, intentions, adherence, and asthma control will be assessed.


Eligibility criteria:
inclusion criteria: * a diagnosis of asthma * a prescription for an inhaled corticosteroid * enrolled in college * between 18-29 years of age * owns a mobile phone exclusion criteria: * cannot read in english

Keywords: mhealth message framing
thyroid nodule gene sequencing in a danish population

Conditions: Thyroid Nodule (Diagnosis); Thyroid Cancer

Summary: this pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of dna and rna in a danish population. patients with thyroid nodules suspected of malignancy is included prospectively. tissue samples are collected for molecular analyses form surgical specimens and bloodsamples, and preoperative clincial features are registered.


Eligibility criteria:
inclusion criteria: * thyroid nodule \>1.5 cm * bsrtc: iv, v, og vi exclusion criteria: * no surgical specimen available * purely cystic nodules
pharmaceutical care and quality of life in conditions related to psychotropic drug use

Conditions: Mental Health Services

Summary: this study aims to assess and describe the impact of pharmaceutical care on identified drug-related problems (drps) in subjects using psycholeptics and psychoanaleptics in primary care, improving subjects' self-assessed quality of life (qol) the hypothesis of the study are: 1. side-effects are the most common drps in subjects using psychotropic medicines in primary care, 2. treatment effectiveness and safety affect the subjects´ qol

the study objectives are to: 1. assess qol in subjects using psycholeptics and psychoanaleptics, 2. analyze identified drps and their causes in subjects using psycholeptics and psychoanaleptics 3. evaluate the correlation between the type and total number of drps identified in a single subject with qol, 4. describe the impact of pharmacists´ intervention in the identification and resolution of the drps and their causes on subjects´ qol.

Eligibility criteria:
inclusion criteria: * adult participants (years 18+) * usage of psycholeptic or psychoanaleptic medicines * residence in istrian county (croatia) exclusion criteria: * minor participants * hospitalization during study participation * unable to live by themselves * unable to participate in study for 3 months

Keywords: mental disorders quality of life drug-related problems
a study of the effect of patient education (talking health together) in improving doctor-patient communication

Conditions: Doctor-patient Communication Improvement

Summary: this study is being carried out to see if patients make the lifestyle changes or take their medication as instructed by their doctor during their visit as a result of the t.h.t. patient-education training. proper information exchange between doctors and patients is an important part of quality health care. although many patients would like more information, they often do not ask for it directly during doctor-patient visits. the patient-training in this study specifically aims at improving patient participation during medical appointments by building communication skills such as requests for information and sharing health concerns with the doctor.


Eligibility criteria:
inclusion criteria: * male or female, aged 40 years of age or greater * clinical documentation of diagnosis not to target of at least one of the following: type ii diabetes mellitus, hypertension or hypercholesterolemia * receive a prescribed medication for the chronic disease for which they were included in the study exclusion criteria: * patients in active phase of cancer treatment (i.e. chemotherapy or radiotherapy at time of study). * inability to carry out the encounter with their physician in english without need of assistance * uncomfortable using a computer for routine activities such as regular access to the web and e-mail.

Keywords: doctor-patient communication encounters patient education training
mindfulness, mental fatigue, inhibitory control and endurance performance in athletes

Conditions: Mental Fatigue

Summary: this study investigated the mediating effect of dispositional mindfulness on the impact of mental fatigue on neurocognitive functions and endurance performance in athletes.

recent research suggests that mental fatigue by prolonged cognitive tasks would impair neurocognitive functions (e.g., executive functions, brain activity) and sports performance, especially inhibitory control and endurance performance. on the other hand, individuals with higher dispositional mindfulness have been linked to greater athletic performance and cognitive functions. still, there is little known whether higher dispositional mindfulness counteracts the detrimental effects of mental fatigue on endurance performance and inhibitory control in athletes. therefore, this study is conducted to investigate whether dispositional mindfulness mediates the effects of mental fatigue on neurocognitive functions and endurance performance in athletes. the qualified participants will visit the lab on two counterbalanced order occasions to complete either a modified incongruent stroop task (mental fatigue condition, mf) or a modified congruent stroop task (control condition, con) for 30 minutes. before and after each cognitive task, participants will be measured for their subjective mental fatigue by a visual analog scale (vas). after each cognitive task, inhibitory control and endurance performance will be evaluated by a flanker task and a graded exercise test (gxt), respectively. furthermore, the general and athletic dispositional mindfulness will be measured using the five facet mindfulness questionnaire (ffmq) and athlete mindfulness questionnaire (amq), respectively. specifically, the targeted primary outcomes are neurocognitive functions (i.e., reaction time, accuracy and erps in flanker task) and endurance performance (i.e., vo2max \& time to exhaustion in gxt); the secondary outcomes are subjective (i.e., vas score)/objective (i.e., reaction time, accuracy in stroop task) mental fatigue, motivation in tasks, mood (i.e., brums-c).

Eligibility criteria:
inclusion criteria: 1. regular sports training at least 4 hours weekly 2. normal or corrected-to-normal vision 3. right-handed exclusion criteria: 1. physical limitation or injury in lower limbs before and during the study 2. diagnosed or self-reported neurological disorders (e.g., epilepsy) 3. diagnosed or self-reported major psychiatric illness (e.g., major depression, schizophrenia)

Keywords: mindfulness athletes mental fatigue inhibitory control endurance performance
chronic diarrhea owing to underlying microscopic colitis

Conditions: Chronic Diarrhea; Microscopic Colitis

Summary: the goal of this observational study is to search for accurate diagnoses for patients with chronic diarrhea and assess the prevalence of microscopic colitis. the main question\[s\] it aims to answer \[is/are\]: does microscopic colitis account for a significant portion of patients with chronic diarrhea? participants will subjected to: * routine laboratory examination. * colonoscopy: a total colonoscopy will be done with visualization of the terminal ileum. biopsies will be taken from each segment of the colon and any abnormal appearing areas, the right-sided colon (cecum, ascending colon, and transverse colon), the left-sided colon (descending colon and sigmoid colon), and the rectum.


Eligibility criteria:
inclusion criteria: * patients with chronic watery diarrhea exclusion criteria: * infectious colitis. * inflammatory bowel diseases (ulcerative colitis, crohn's disease, and indeterminate colitis). * systemic disease associated with chronic diarrhea, e.g. diabetes mellitus and thyroid disease. * drugs causing chronic diarrhea, e.g. antibiotics, antidepressants, and angiotensin-converting enzyme inhibitors. * chronic diarrhea of decreased digestion as in pancreatic insufficiency and bile acid deficiency.
brief intervention and/or distribution of free condoms for travelers

Conditions: Sexually Transmitted Infections

Summary: the objective of this study is to assess the impact of a structured intervention and/or free distribution of condoms during the pre-travel consultation on sexual risk behavior of young persons traveling alone.

all persons aged 18 - 44 years planning to travel alone and attending the travel clinic of the medical outpatient clinic in lausanne will be asked to participate. the subjects will be randomized into three groups: 1. no intervention, 2. free condoms without further explanations, 3. a structured intervention of 5 minutes on sti risk reduction plus free condoms. the structured interventions will include information about the number of travelers engaging in new sexual relationships, the different types of sti and their prevalence in different countries and population groups. the subjects will complete a pre-travel questionnaire prior to the medical consultation. a post-travel questionnaire will be sent to them 10 days after their trip. the questionnaires will include questions on demographic characteristics, sexual habits, alcohol/tobacco/marijuana consumption and sexual relationships during the trip.

Eligibility criteria:
inclusion criteria: * age: 18 - 44 years * travelling without the regular partner exclusion criteria: * refusal of patient to participate

Keywords: travel casual sexual relationships condoms structured intervention
lpb combined with qlb using single-needle technique (lpqlb-snt) for hip arthroplasty

Conditions: Hip Osteoarthritis; Anesthesia, Local; Hip Fractures; Osteonecrosis of Femoral Head

Summary: total hip arthroplasty (tha) is one of the most successful orthopedic procedures to effectively relieve pain and restore function in patients with hip osteoarthritis, osteonecrosis of femoral head and hip fracture.the lumbar plexus block (lpb) is currently used as the standard regional anesthesia technique to provide postoperative pain management after tha. the lumbar plexus (lp) originates from t12 to l5. in general, multiple-needle nerve blockade procedure is needed to block different branches of lp. therefore, we need more time to finish the regional anethesia procedure and it's not easy for an inexperienced anesthesiologist to master the technique absolutely. in addition, multiple injections will increase the discomfort of the patients. we aim to investigate the effects of lumbar plexus combined with quadratus lumborum block using single-needle technique with shamrock method as an alternative regional anesthesia.


Eligibility criteria:
inclusion criteria: 1. body mass index (bmi) between 18.5 and 30kg/m2 and the weight ≥50kg 2. american society of anesthesiologists (asa) classification i-ii 3. postero-lateral operative incision approach unilateral hip arthroplasty 4. aged 18-75 exclusion criteria: 1. patient refusal 2. patients with coagulopathy or on therapeutic anticoagulation 3. pregnancy 4. multiple trauma 5. hypersensitivity or allergy to ropivacaine 6. history of ankylosing spondylitis or spinal surgery 7. lower extremity neuropathy 8. unable to communicate

Keywords: lumbar plexus block quadratus lumorum block total hip arthroplasty single-needle shamrock approach