Kornimate/medical-research-clean huggingface dataset:
cornual wedge resection outcome

Conditions: Ectopic Pregnancy; Laparoscopic; Cornual Pregnancy

Summary: cornual pregnancy is a rare form of ectopic pregnancy that accounts for 2% to 4% of ectopic pregnancies, with a mortality rate between 2.0% and 2.5%. traditionally, interstitial pregnancies were treated by laparotomy with cornial resection or hysterectomy. however, nowadays, increasingly interstitial pregnancies are treated by laparoscopic cranial resection. although this technique can potentially protect the fertility of the patient, it carries a serious risk of bleeding and requires a surgical experience.


Eligibility criteria:
inclusion criteria: * cornual ectopic pregnancy * patients undergoing laparoscopic cornual wedge resection exclusion criteria: * medical treatment area due to cornual pregnancy * laparotomy * conservatively managed patients
a trial of tisotumab vedotin in japanese subjects with advanced solid malignancies

Conditions: Solid Tumor

Summary: open label phase 1/2 trial of tisotumab vedotin in japanese subjects with advanced solid malignancies

part 1 of this trial will determine the maximum tolerated dose (mtd) and/or the recommended phase 2 dose (rp2d) and the safety profile of tisotumab vedotin in subjects with solid malignancies. part 2 of this trial will enroll subjects with cervical cancer to provide further data on the safety, tolerability, pk and anti-tumor activity

Eligibility criteria:
inclusion criteria (main): * part 1 only: subjects with locally advanced or metastatic solid tumors, who have experienced disease progression while on standard therapy or are intolerant of, or not eligible for, standard therapy. * part 2 only: subjects with extra-pelvic metastatic or recurrent cervical cancer including squamous cell, adenocarcinoma or adenosquamous histology who have experienced disease progressed on standard of care chemotherapy in combination with bevacizumab, if eligible. patients must not have received more than 2 prior systemic treatment regimens for recurrent or metastatic cervical disease. * measurable disease according to recist v1.1 * must be at least 20 years of age on the day of signing informed consent * eastern cooperative oncology group (ecog) performance status of 0 or 1 * is not pregnant, breastfeeding, or expecting to conceive children within the projected duration of the trial and for at least 6 months after the last trial treatment administration * women of childbearing potential must agree to use adequate contraception during and for 6 months after the last dose of trial treatment administration * a man who is sexually active with a wocbp and has not had a vasectomy must agree to use a barrier method of birth control (part 1 only) * must provide signed informed consent before any trial-related activity is carried out. exclusion criteria (main): * part 2 only: clinically relevant bilateral hydronephrosis which cannot be alleviated by ureteral stents or percutaneous drainage. * known past or current coagulation defects leading to an increased risk of bleeding. * ongoing major bleeding. * has an active ocular surface disease at baseline. subjects with prior history of cicatricial conjunctivitis are ineligible

Keywords: tisotumab vedotin cervical cancer
pilot study of 18f-flt pet

Conditions: CNS Brain Metastasis; Head and Neck Cancer; Lung Cancer; Prostate Cancer; Esophageal Cancer

Summary: fractionated radiotherapy induces an observable change in the proliferative activity as assessed by pre-treatment and early-treatment 18f-flt pet imaging. this study is designed to investigate 18f-flt as a pet imaging agent for predicting treatment effectiveness in several tumors and will serve as a pilot study to a planned po1 submission


Eligibility criteria:
inclusion criteria: * able to tolerate a pet/ct scan * age of 18 or older * signed informed consent * being considered for radiotherapy for treatment of cns mets, head and neck cancer, lung cancer, prostate cancer or esophageal cancer exclusion criteria: * prior xrt to site being studied * severe claustrophobia or inability to tolerate pet/ct * unable to provide written consent * pregnant or breastfeeding women
the effect of a dual trigger on intracytoplasmic sperm injection (icsi) reproductive outcomes

Conditions: Pregnancy; Ovarian Hyperstimulation Syndrome

Summary: the use of antagonist controlled ovarian stimulation protocols has allowed the use of gnrh agonist to be used for final oocyte maturation. the use of gnrh agonist as ovulation trigger has been shown to reduce the risks for ovarian hyperstimulation syndrome (ohss), but its sole use results in reduced embryo implantation due to luteal phase insufficiency. the combination of gnrh agonist and variable doses of hcg for final oocyte maturation has been shown to overcome the luteal phase insufficiency effecting endometrial receptivity. in this study the investigators will test the hypothesis that using gnrh agonist (0.2mg triptorelin) and a full dose of hcg (6500iu ovitrelle) for final oocyte maturation in normoresponders will increase oocyte maturity, embryo quality and embryo implantation and reduce ovarian hyperstimulation syndrome, as compared to the traditional hcg (full dose) alone trigger.


Eligibility criteria:
inclusion criteria: * age; \< 40 years * cycle number; cycles 1 or 2 * antral follicle count; \>10 and \<25 * bmi; \>18 and \<30 * normogonadotrophic cycle length; 24 to 25 days * male; ejaculated semen only exclusion criteria: * presence of endocrine disorders; (diabetes mellitus, hyperprolactinemia, thyroid dysfunction, congenital adrenal hyperplasia, cushing syndrome, or polycystic ovary syndrome) * previous major uterine surgery (that would affect endometrial receptivity) secondary exclusion criteria * \<5 follicles at the time of trigger * \<2 full formed blastocyst on day 5 of embryo culture

Keywords: dual trigger hcg gnrh agonist icsi pregnancy ohss
the effect of music on pain and anxiety in patients receiving chemotherapy during covid-19

Conditions: Cancer; Chemotherapy

Summary: introduction: this study has been conducted to determine the effect of music on pain and anxiety levels in patients receiving chemotherapy during covid-19. methods: the research has been carried out in a real trial model with adult patients receiving chemotherapy. the sample of the study is consisted of 92 patients (45 in the experimental group and 47 for the control group). the data have been collected by the researcher with google forms (using state and transient anxiety inventory and visual analog skala) between march 2020 and july 2020, through the links sent to the phones of participants on the day they received chemotherapy. results: the mean scores obtained from the post-test stai (53.11±4.77) and vas (3.44±2.53) scales in the experimental group have been determined to statistically significantly decrease when compared to the pre-test measurement data (stai:54.26±4.26; vas:4.22±2.41) (p\<0.05). no statistically significant difference has been determined between pre-test and post-test mean scores of the patients in the control group. conclusion: it has been observed that music applications reduce the pain and anxiety levels of patients receiving chemotherapy during the covid-19 process. it can be recommended to use music applications in the management of pain and anxiety symptoms.


Eligibility criteria:
inclusion criteria: * over the age 18, * being able to communicate, * being literate, * having no diagnosis of psychiatric, * have the necessary technological equipment (phone, internet, etc.) exclusion criteria: * existing infection * receiving palliative chemotherapy

Keywords: anxiety covid-19 music pain patients receiving chemotherapy
investigating the immediate effects of kinesio tape and biomechanical tape on strength and performance: a randomized placebo-controlled cross-over trial

Conditions: Sports Physical Therapy; Sports Performance

Summary: there has been an increasing interest in kinesiology tape(kt) and biomechanical tape(bt) in clinics and athletic competitions. recently; the performance increasing effect of taping methods on healthy subjects in sports is being investigated.

kinesio taping (kt) is a technique utilizing a two way elastic tape originally created by kenzo kase in the 1970s. kt is a complementary method which is used as an adjunct to major therapy approaches in various musculoskeletal and neurological diseases.4 kt is employed in sports injuries and various health problems; but there is limited scientific evidence evaluating kt effectiveness and the results are inconsistent.5 one of the kt potential benefits is that of raising the range of motion through increasing blood circulation or through stimulation of cutaneous mechanoreceptors and this way it affects fascial tissue.6-8 biomechanical taping (bt) is a technique utilizing a four way elastic tape originally created by ryan kendrick in the 2010s. bt is a complementary method for supplementing load absorption, force contribution and modifying movement. bt affects tissues and movement in a mechanical way and it is almost a completely different method from kt. kase's hypothesis is that kt affects fascial tissues and mechanoreseptors, but kendrick's hypothesis is that bt ,which is applied in shortened position and cross joint segments, will gain potential energy in case of an extremity realized movement with antagonist activity. then the weak agonist muscle gets activated for repositioning the extremity; this potential energy turns to kinetic energy like a released bow. as a result of kinetic energy, it may support the movement with using passive mechanical strength.9 in this study, the investigators aim to illustrate immediate effects of various taping methods on the performances of healthy subjects. in that way the investigators test hypothesis that different taping methods affect healthy subjects to improve performance. the investigators; investigate strength, active range of motion and vertical jump height as a parameters of performance with no tape(nt), sham tape(st), kt and bt.

Eligibility criteria:
inclusion criteria: * 18-24 bmi * physically active according to international physical activity questionnarie (ipaq) exclusion criteria: * any known systemic diseases or medical condition * sensitive or fragile skin, * allergic diseases * pregnancy or pregnancy suspicion * using of sedative, psychosomatic or analgesic drugs

Keywords: kinesiology tape biomechanical tape performance muscle strength vertical jump
effect of silymarin in metastatic colorectal cancer patients

Conditions: Metastatic Colorectal Cancer

Summary: this work is aim to assess the antitumor effect of silymarin in patients with metastatic colorectal cancer receiving chemotherapy with or without target therapy (bevacizumab).

colorectal cancer (crc) ranks as the third most common cancer globally and second in terms of mortality . although crc incidence rates are higher in high-income compared with low-to-middle-income countries (lmics), mortality is higher in lmics. extensive research within the last decade has shown that silymarin can suppress the proliferation of a variety of tumor cells; this is accomplished through cell cycle arrest at the g1/s-phase, induction of cyclin-dependent kinase inhibitors, down-regulation of anti- apoptotic gene products, inhibition of cell-survival kinases and inhibition of inflammatory transcription factors (e.g., nuclear factor- kappa b) through suppression of nuclear factor- kappa b-regulated gene products, including cyclooxygenase-2, lipoxygenase, tumor necrosis factor and interleukin-1. silymarin can also down-regulate gene products involved in the proliferation of tumor cells (epidermal growth factor receptor, cyclooxygenase-2), invasion (matrix metallopeptidase 9), angiogenesis (vascular endothelial growth factor) and metastasis (adhesion molecules). silymarin was reported to alter the expression of apoptosis-related proteins including bcl2 associated x protein to induce apoptosis in human gastric cancer cells in a concentration-dependent manner. silymarin has also been shown to sensitize tumors to chemotherapeutic agents through down-regulation of the multidrug resistance protein and other mechanisms. in addition to its chemo-preventive effects, silymarin exhibits antitumor activity against human tumors in rodents. so we aim to assess the antitumor activity of silymarin in metastatic colorectal cancer patients receiving chemotherapy.

Eligibility criteria:
inclusion criteria: * - patients with histologically and/or radiologically confirmed diagnosis of metastatic colorectal carcinoma. * patients who received folfox or xelox as first line chemotherapy * both genders. * age ≥18 years old. * performance status 0-1 according to the eastern cooperative oncology group (ecog). * patients with adequate hematologic parameters (white blood cell count ≥3000/mm3, granulocytes ≥1500/mm3, platelets ≥100,000/mm3, hemoglobin ≥ 8 gm/l). * patients with adequate renal functions (serum creatinine ≤1.5 mg/dl). * patients with adequate hepatic functions (bilirubin ≤1.5 mg/dl or albumin ≥3 g/dl). exclusion criteria: * - patients with active liver diseases (chronic viral hepatitis, autoimmune hepatitis, alcoholic hepatitis, wilson's disease, hemochromatosis, or cirrhosis). * patients with a history of other malignancy. * patients with brain metastasis. * patients with active infection. * patients with ras wild type cancer. * patients on chronic use of corticosteroids.
a randomized trial to assess patient quality of life and function after alternative surgeries for pathologic fractures of the femur

Conditions: Proximal Femoral Metastases

Summary: the purpose of this study is to look at two different types of surgeries regularly used for treating cancer that has spread to and weakened the thigh bone (femur). because it is not known which of these surgeries is best, the investigators will compare the results of the two procedures. they are looking to see if differences exist (after surgery) in function, quality of life, pain control, and possible complications.


Eligibility criteria:
inclusion criteria: * surgeon's estimated survival ≥ 1 month * patients presenting for orthopaedic evaluation with a painful impending pathologic femur fracture or displaced pathologic femur fracture in the intertrochanteric, pertrochanteric, or subtrochanteric region of the proximal femur. the anatomic region of interest is defined by a line drawn from the base of the femoral neck to 5 cm below the base of the lesser trochanter or 2 diaphyseal shaft widths, whichever is greater. * patients with an impending fracture who have had bevacizumab are eligible provided there will be a 3-week window between their last infusion and surgery. * diagnosis of widespread visceral and/or osseous metastatic disease based on clinical and radiographic evidence. (patients may continue on study if surgery shows a non-malignant process.) * all cancer diagnoses, except lymphoma, will be eligible exclusion criteria: * estimated survival \<1 month * a large soft tissue mass or other disease involving an area outside of the defined pertrochanteric anatomic region described above. (patients excluded based on intraoperative findings will be replaced on the study.) * prior surgical treatment of the area (i.e., revision cases). a biopsy does not constitute prior surgical treatment. * radiographic evidence of an intramedullary occlusion by blastic metastases that would necessitate an alternative method of treatment, such as a plate/screw construct. * diagnosis of lymphoma * age \< 18 years * patients with advanced hip arthritis on radiographic imaging * previous randomization for a contralateral procedure as part of this study

Keywords: pathologic fractures hip replacements 12-287
serum hepcidin, haemoglobin level and iron status in chronic kidney disease patients (ckd) with anaemia

Conditions: CKD Stage 4

Summary: the current study is planned to assess possible relationships of serum hepcidin levels with haemoglobin levels, inflammation and iron statuses in stage 4 ckd patients.


Eligibility criteria:
inclusion criteria: * adult patients (\>18 years) with anaemia who had ckd stage 4 with glomerular filtration rate (gfr) 15-29 ml/min/1.73 m2 exclusion criteria: * subjects with blood transfusion within the preceding 3 months. myocardial infarction (mi) history within the preceding 3 months, surgical history within the preceding 3 months, malignancy. advanced liver cirrhosis. uncontrolled diabetes
gastroesophageal reflux disease in azerbaijan

Conditions: Gastroesophageal Reflux Disease

Summary: to evaluate the prevalence of gastroesophageal reflux disease in azerbaijan. it is intended to evaluate the prevalence of the disease in the regions as well as the capital by cluster sampling ,ethitology and to compare the outcomes depending on the geographical location.

it is an observational, nationwide study. the gerd questionnaire (1994) requested from mayo clinic, was received and validated. the questionnaire was translated by 3 individuals from english to azeri and back trasnlated by 3 native english speakers. power analysis was performed. the research was presented for the approval to ethical committee of azerbaijan medical university. prior to the actual study, a pilot study with smaller number of participants was performed and the results were evaluated. cluster sampling methodology was provided by the statistical department of azerbaijan medical university. 110 employees were hired for using a survey in different regions of azerbaijan. written consent was obtained from every person evaluated. statistical ananlysis was performed.

Eligibility criteria:
inclusion criteria: * age: 18-80 * both genders * hearburn * belching * regurgitation exclusion criteria: * protom pomp inhibitor use * antibiotic use in the last 4 weeks * upper gi surgery

Keywords: gastoesophageal reflux disease prevalence azerbaijan
utilization of rehabilitation prior to surgery among patients with anterior-cruciate ligament knee injury

Conditions: Anterior-cruciate Ligament Knee Injury

Summary: this research aims to assess physiotherapy utilization in the treatment of patients with an anterior-cruciate ligament knee injury, when delivered before their surgery (prehab), and its potential effects on absence from work, and patients global health consumptions (before and after the surgery).

based on the codes generated from french national health database, patients with prehab (+post-surgery rehabilitation) will be compared to patients receiving only post-surgery rehabilitation

Eligibility criteria:
inclusion criteria: - first episod of acl-surgery exclusion criteria: * no history or previous acl-surgery * no rehabilitation after surgery

Keywords: rehabilitation surgery health consumption
effect of administration of 3rd generation cephalosporin on the digestive carrying of 3rd generation cephalosporin-resistant enterobacteriaceae (cef-impact)

Conditions: Infectious Disease - Resistant Enterobacteriaceae (Diagnosis)

Summary: the aim of this study was to compare the frequency of occurrence of digestive carrying of 3rd generation cephalosporin-resistant enterobacteriaceae (eb c3g-r), acquired during hospitalization in one of the participating departments, between patients treated with ceftriaxone and patients treated with cefotaxime


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * indication for antibiotic treatment with a 3rd generation injectable cephalosporin (cefotaxime or ceftriaxone) * signed informed consent exclusion criteria: * hypersensitivity to ceftriaxone or cefotaxime, to another cephalosporin or to any of the excipients of the specialities concerned. * history of severe hypersensitivity (e.g., anaphylactic reaction) to another class of antibacterial agent of the beta-lactam family (penicillins, monobactams and carbapenes) * subcutaneous administration of ceftriaxone * pregnant and breastfeeding woman * suspicion of pseudomonas infection or documented pseudomonas infection requiring ceftazidime treatment * suspicion of group iii enterobacteriaceae infection or group iii enterobacteriaceae infection requiring cefepime treatment
a study of the effectiveness of a local injection of chemotherapy for retinoblastoma

Conditions: Retinoblastoma

Summary: over the past 15 years, intravenous chemotherapy has become the most popular conservative (eye-saving) method for retinoblastoma treatment because it is often effective and usually safe. in recent years, there has been much interest in providing highly focused (focal) chemotherapy to a diseased organ including the liver, brain, and eye. with focused chemotherapy, the chemotherapy drugs are injected directly into the ophthalmic artery (the artery that supplies blood to the eye). a benefit of focal chemotherapy delivery is that it decreases the chance of toxicity to other organs such as bone marrow suppression (causing low blood counts) and the development of other cancers in the future.

the management of retinoblastoma includes systemic chemotherapy (carboplatin, etoposide, and vincristine), thermotherapy, cryotherapy (freezing treatment), laser photocoagulation, plaque radiotherapy, external beam radiotherapy, and enucleation. the treatment is tailored to each individual case. over the past 15 years, intravenous chemotherapy has risen as the most popular conservative (eye-saving) method for retinoblastoma management because it is effective and safe. in recent years, there has been keen interest in providing chemotherapy more focally to a diseased organ including the liver, brain, and eye. the benefit of focal chemotherapy delivery is to avoid toxicity to other organs and this toxicity includes the risk of future cancers.

Eligibility criteria:
inclusion criteria: * advanced retinoblastoma in one or both eyes * recurrent retinoblastoma after failure of previous treatment * no age limit (usually kids presenting with retinoblastoma present in the 1st two decades of life) * judged by principal investigator to be medically and physically able to undergo the procedure exclusion criteria: * recurrent retinoblastoma which is treatable with other conservative measures * invasive retinoblastoma (retinoblastoma that has grown locally outside of the eye, for example, into the bone around the eye)

Keywords: retinoblastoma intraarterial chemotherapy melphalan carboplatin
superiority trial between sotair® device attached to manual resuscitator versus ventilation alone

Conditions: Airway Management; Respiration, Artificial

Summary: effective respiratory ventilation is achieved by moving the right amount of air to and out of the lungs while keeping the pressures at a safe level. a disposable safety device, adult sotair®, was created to improve manual ventilation delivery. in this superiority study, the investigators will perform two-group cross over randomized design to test the superiority of the adult sotair® device compared to manual ventilation alone.

poor manual ventilation technique is a well-documented problem which occurs irrespective of a provider's qualifications or experience. a disposable safety device, adult sotair®, was created to improve manual ventilation delivery among providers. the device is attached to a bag valve mask (i.e. manual resuscitator) and employs a flow limiting valve mechanism to minimize excessive pressure in the airway system without venting air by capping peak flow rates at 55 l/min. for an average adult with normal lung compliance and resistance, this corresponds to a maximum airway pressure of approximately 20 cmh2o which minimizes air entry into the stomach. in this superiority study, the investigators will use a two-group cross over randomized design to test the superiority of the adult sotair® device compared to manual ventilation alone with respect to airway pressure.

Eligibility criteria:
inclusion criteria: * adult patients who are scheduled for non-emergency surgery with general anesthesia (w/artificial airway) at rhode island hospital. * american society of anesthesiologists physical status 1 and 2 exclusion criteria: * american society of anesthesiologists physical status \>3 (e.g. respiratory disease) * oropharyngeal or facial pathology

Keywords: mechanical ventilation general anesthesia bag mask ventilation adult sotair device