Kornimate/medical-research-clean huggingface dataset:
screening protocol for adults with adhd

Conditions: ADHD

Summary: the objective of this protocol is to establish a comprehensive screening process to evaluate the eligibility of potential adult subjects for appropriate adhd clinical research studies

to address the needs of the large number of adults who contact the adult adhd program at massachusetts general hospital annually, we have sought approval for several research studies aimed at evaluating critical components of the needs of this population. potential participants for those studies present with a widely varied set of complaints not always discernable in a telephone screening interview. this state of affairs often makes it difficult to ask subjects to sign a specific protocol's consent form without obtaining additional clinical information. because of this, we have potential subjects consent to undergo an in-depth clinical assessment that will allow them to be screened by a clinician for eligibility to a diverse clinical research program available to them.

Eligibility criteria:
inclusion criteria: 1. males and females ages 18-55 2. subjects must have a dsm-iv or dsm-v diagnosis of adhd, as determined by a clinical evaluation based on dsm-iv or dsm-v criteria exclusion criteria: 1. history of head trauma with loss of consciousness, organic brain disorders, seizures, or neurosurgical intervention. 2. any significant medical condition, in the judgment of the investigator 3. mental retardation 4. pregnancy of lactation 5. subjects with a known recent history (within the past 6 months) of illicit drug or alcohol dependence 6. sensory difficulties such as deafness or blindness

Keywords: adhd adults
sucrosomial iron in patients with celiac disease and ida

Conditions: Celiac Disease; Iron Deficiency Anemia

Summary: sucrosomial iron (sideral® forte) is a preparation of ferric pyrophosphate conveyed within a phospholipid membrane associated with ascorbic acid, is a new-generation oral iron which shows a high gastrointestinal absorption and high bioavailability with a low incidence of side effects due to lack of any direct contact with intestinal mucosa. in comparison with the other standard oral iron preparations, sucrosomial iron seems to be a promising new strategy of iron replacement in cd patients.


Eligibility criteria:
inclusion criteria: * proven celiac disease * iron deficiency anemia exclusion criteria: * other autoimmne diseases * pregnancy psychiatric disorders
outcome of two protocols in poor responders in assisted reproductive technology (art) cycle

Conditions: Infertility

Summary: about 9 to 24 % of women undergoing in vitro fertilization (ivf) treatment respond poorly to the usual gonadotrophin stimulation protocol applied. several induction ovulation treatments have been suggested for increasing pregnancy rate. in this study, the investigators will compare the outcome of microflare protocol and flare up regimen in poor responders.

in this randomized clinical trial study, a total of 200 infertile women with poor ovarian response who undergo ivf / icsi treatment cycle at royan institute will enroll in this study and will randomly be divided into two groups of 100 patients. this study has been approved by royan ethics committee and written consent will be obtained from each patient. the patients will be randomized to one of two groups of flare up or microdose gnrh agonist flare up. luteinizing hormone (lh), follicle stimulating hormone (fsh), estradiol, will be evaluated on day 2 or 3 and when follicle size become \>14. 2 weeks after embryo transfer, the patients will be tested for serum β-hcg for assessing the pregnancy. the clinical pregnancy will be clarified by the number of women with gestational sacs on transvaginal sonography at 4-6 weeks of gestation. in the calculation of implantation, the number of gestational sacs will be considered.

Eligibility criteria:
inclusion criteria: poor responders (presence of at least two of following items is necessary for inclusion to the study) * history of cycle cancellation * history of oocyte number 3 (in previous cycle) * history of number of antral follicle \< 5 in previous cycle * age≥38 * fsh\>12 on day 2 or 3 * ovarian volume 3 cm3 exclusion criteria: * male factor (azospermi) * myoma ≥6cm * one way ovary * tumor or cyst \>13mm * age \>42

Keywords: poor responder flare up micro dose gnrh agonist flare up ivf/icsi
understanding of genetic risk information for type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: this research study is being conducted to learn about how health and genetic literacy (i.e., how well a person understands health and genetic information) affects a person's ability to understand genetic risk information for type 2 diabetes and whether that person chooses to change their lifestyle and health behaviors to reduce their risk. the investigators also want to learn if the manner in which the genetic risk information is communicated affects the level of understanding and potential behavior changes. participants will be tested for genetic risk of developing type 2 diabetes and will received results either via a web-based computer program, or in-person from a genetic counselor.


Eligibility criteria:
inclusion criteria: * ages 18 or older * speak fluent english * have an email address and access to the internet * not diagnosed with type 2 diabetes exclusion criteria: -

Keywords: type 2 diabetes health literacy genetic literacy genetic risk
optimal nutritional palliation of obstructed gej cancer

Conditions: Esophageal Cancer

Summary: the main goal of this trial is to assess whether it's feasible to conduct a larger, full-scale study comparing the use of gastrostomy (g-tubes) and stents in patients with unresectable cancer of the stomach and/or esophagus, and to evaluate their impact on patients' quality of life. additional objectives include examining the rates of complications, the need for additional treatments, and the total number of hospital days over a three-month period.


Eligibility criteria:
inclusion criteria: * patients aged 18 years of age and older who present with an obstructing metastatic or unresectable gastroesophageal cancer. exclusion criteria: * patients under the age of 18 years. * prior esophageal stent or gastrostomy tube

Keywords: metastatic obstructing
ginseng hrg80 in stress and fatigue

Conditions: Psychological Stress

Summary: this study evaluates the effects of a specific herbal preparation of panax ginseng in preventing symptoms of stress in healthy individuals.

hrg80 is an herbal preparation of panax ginseng with a higher concentration of bioavailable ginsenosides than typical korean ginseng. this study will test whether hrg80 is effective at preventing symptoms of stress, such as fatigue, impaired memory, difficulty in concentration, attention deficit, restlessness, and irritation related to daily work situations of healthy individuals in comparison to placebo and a standard pananx ginseng with a lower concentration of ginsenosides.

Eligibility criteria:
inclusion criteria: * individuals experiencing at least one symptom of stress and fatigue during 8 hours of mental work with a computer. * men and women ages 18-65 (all races and ethnicities) * able to understand and participate in an 11-week study exclusion criteria: * taking medicine or dietary supplements which may have potential effects on cognitive function * consuming more than 1 cup of coffee daily (in the morning).

Keywords: panax ginseng red ginseng korean ginseng adaptogen
a study of indinavir sulfate given together with stavudine to hiv-positive patients

Conditions: HIV Infections

Summary: the purpose of this study is to see if it is safe and effective to give indinavir sulfate plus stavudine to hiv-infected patients who have already been treated with zidovudine.


Eligibility criteria:
inclusion criteria concurrent medication: allowed: * prophylaxis with aerosolized pentamidine, topical antifungals, tmp / smx, dapsone, or isoniazid. patients must have: * hiv infection. * cd4 count 50 - 500 cells/mm3. * prior azt use for more than 6 months or documented intolerance to azt with more than 6 months use of another anti-hiv therapy other than d4t or any protease inhibitor. * no active opportunistic infection or visceral kaposi's sarcoma. note: * patients with hemophilia may be enrolled at discretion of investigator. exclusion criteria co-existing condition: patients with the following symptoms or conditions are excluded: * symptomatic neuropathy. * acute hepatitis. concurrent medication: excluded: * antiretrovirals other than specified in protocol. * chronic therapy for an active opportunistic infection. * immunosuppressive therapy. prior medication: excluded: * any prior protease inhibitor or d4t. * any nucleoside analogs within 2 weeks prior to study entry. * investigational agents or immunomodulators within 30 days prior to study entry. required: * more than 6 months of prior azt unless intolerant, in which case more than 6 months of another anti-hiv therapy (other than protease inhibitors or d4t).

Keywords: drug therapy, combination acquired immunodeficiency syndrome aids-related complex stavudine hiv protease inhibitors indinavir
effectiveness of a physiotherapy treatment plan in lateral epicondylalgia

Conditions: Humeral Epicondylitis, Lateral

Summary: purpose: test the effectiveness of a physiotherapy treatment in 90 patients with lateral epicondylalgia (le).

methods: le is a musculoskeletal pain around the lateral epicondyle that may also present with decreased grip strength and/or neuromuscular disorders. an evidence-based treatment plan of dry needling, stretching and eccentric exercise in the patient with lateral epicondylalgia is established. it is carried out in two sessions, one session every 10 days and lasts about 45 minutes. there are three intervention arms: dry needling, atopic gel and nsaids, 30 patients in each group (n=90).

Eligibility criteria:
inclusion criteria: * diagnosed with lateral epicondylalgia exclusion criteria: * diagnosed with compressive nerve syndromes with irradiation to the upper limb

Keywords: dry needling stretching eccentric exercise tennis elbow humeral epicondylitis, lateral
a research study looking at the comparability (bioequivalence) of two versions of semaglutide

Conditions: Healthy Volunteers; Overweight; Obesity

Summary: the study will look at how two different versions of semaglutide reach and stay in the blood after injection. the study aims to show similar levels of semaglutide in the blood when using the different versions. participants will get both versions of semaglutide. the order in which participants receive the versions is decided by chance. participants will get the medicines as an injection under the skin of the belly with the use of a pen-injector. the study will last for about 11 to 17 weeks. participants will have 27 visits with the study doctor. at 2 visits, participants will stay in the clinic for 4 days and 3 nights. participants may have to stop the study if the study doctor thinks that there are risks for their health. women cannot take part if pregnant, breast-feeding or planning to become pregnant during the study period.


Eligibility criteria:
inclusion criteria: * male or female, aged 18-55 years (both inclusive) at the time of signing informed consent. * body mass index between 20.0 and 27.0 kg/m\^2 (both inclusive). exclusion criteria: * female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using highly effective contraceptive methods. * any disorder which in the investigator's opinion might jeopardise subject's safety, evaluation of results, or compliance with the protocol.
mutation analysis of 17βhydroxysteroid dehydrogenase 3 deficiency

Conditions: Pseudohermaphroditism

Summary: to disclose the molecular pathology of our 3 families with 17βhsd3 deficiency.

17βhydroxysteroid dehydrogenase 3 (17βhsd3) deficiency is a rare cause of male pseudohermaphroditism. the incidence is reported to be 1: 147,000 in the netherlands. fewer than one hundred affected 46, xy males were reported in the literature, and no such case has been reported in taiwan before. the 46, xy patients have ambiguious or complete female external genitalia. they are mostly unrecognized at birth and reared as female. they often draw medical attention when they receive operation for inguinal hernia or during puberty, clitoromegaly and musculization were noticed. however, the homozygous or compound heterozygous genetic females are asymptomatic. the 17βhsd3 catalyze the conversion of androstenedione to testosterone, the last step in the synthesis of testosterone. therefore, the serum levels of androstenedione are elevated and testosterone or dihydrotestosterone are in the low range in these affected 46, xy individuals. the clinical diagnosis is made by hcg stimulation test, because androstenedione-to-testosterone ratio is abnormally elevated in these patients. but the molecular basis of 17βhsd3 deficiency was not determined till recent decade. the hsd17b3 gene was elucidated in 1994, and composed of 11 exons. several missence mutation and splice mutation were identified. but the precise action and tissue distribution of 17βhsd3 still need to be clarified. the wölffian ducts virilze normally in the embryonic stage and the serum concentration of testosterone achieve to the normal range in the pubertal stage. the exact mechanism is not understood clearly and peripheral conversion under other isozymes was suggested in some studies. the purpose of this study is to disclose the molecular pathology of our 3 families with 17βhsd3 deficiency.

Eligibility criteria:
inclusion criteria: * patients with 17β-hydroxysteroid dehydrogenase 3 deficiency and their family
exercise preconditioning in ovarian cancer

Conditions: Ovarian Cancer

Summary: the purpose of this study is to determine if exercise preconditioning can mitigate the off target effects of chemotherapy treatment on measures of cardiovascular function, peripheral neuropathy, and quality of life.

while survivorship for those diagnosed with epithelial ovarian cancer has continued to improve, the significant off target effects of adjuvant and neoadjuvant chemotherapy have become more prominent. these off-target effects include increased risk of cardiovascular disease, neuropathy, and decreased quality of life. exercise initiated prior to chemotherapy induction and continued through treatment has promise in terms of preserving vo2peak and potentially mitigating the negative cardiovascular and neuropathic effects of chemotherapy. the goal of this study is to examine the effects of initiating exercise prior to any oncologic therapy and sustaining this exercise paradigm in newly diagnosed women with ovarian cancer who are undergoing initial surgery and chemotherapy.

Eligibility criteria:
inclusion criteria: * age 18 years or over * presumed diagnosis of ovarian cancer and a planned chemotherapy regimen of a taxane and carboplatin with or without vegf inhibition * physician clearance for exercise training exclusion criteria: * any patient unable/unwilling to cooperate with all study protocols * cancer recurrence * previous treatment with chemotherapy in the last 5-years * medical/orthopedic co-morbidities that preclude exercise training * significant heart, liver, kidney, blood, or respiratory disease precluding exercise participation * peripheral vascular disease * acute infectious disease or history of chronic infections

Keywords: cardiotoxicity ovarian cancer exercise training chemotherapy cardiovascular toxicity ovarian cancer chemotherapy
cereset research for performance improvement in a hospital nursing unit

Conditions: Health Personnel; Stress; Anxiety; Insomnia; Depression

Summary: the purpose of this study is to explore whether an implementation process composed of offering cr to staff in a single hospital nursing unit has any potential impact on unit-level quality measures post-implementation.

this is a pre-post design quality improvement project and implementation study, evaluating implementation measures, group level quality measures using qi methodology, and individual-level behavioral and performance measures before and after implementation of the cereset research (cr) evidence-based intervention among nursing unit staff. individual-level behavioral symptoms and a nursing performance metric will be evaluated among healthcare workers in the nursing unit in the pre- and post-implementation timeframes among individuals who consent to participate in these evaluation activities. up to 40 members of the unit will have the opportunity to enroll in the acoustic echoing neurostimulation intervention during the implementation timeframe. the neurostimulation intervention consists of 4 cereset research sessions of audible tones echoing current brainwave activity, and individual level behavioral symptoms will be collected following the last intervention session.

Eligibility criteria:
inclusion criteria: * ability to comply with basic instructions and be able to sit still, comfortably during sessions. * healthcare worker in the orthopedic trauma unit at atrium health wake forest baptist, aged 18 years and older. exclusion criteria: * unable, unwilling, or incompetent to provide informed consent. * physically unable to come to the study visits. * severe hearing impairment (because cr involves acoustic stimulation that participants would need to be able to hear). * weight is over the chair limit (400 pounds). * currently enrolled in another cereset research study. * use of the following modalities within one month before enrollment: electroconvulsive therapy (ect), prior use of transcranial magnetic stimulation (tms), transcranial direct current stimulation (tdcs), alpha stimulation, eye movement desensitization and reprocessing (emdr), brain spotting, neurofeedback, biofeedback, or deep brain stimulation (dbs). individuals will be given the opportunity to discontinue these techniques for one month and then enroll. * known seizure disorder. * thoughts of active suicide within the last 3 months.

Keywords: anxiety stress insomnia cereset research brain electrical activity neurotechnology hirrem neuromodulation acoustic stimulation healthcare worker
clinical comparison of two daily disposable contact lenses

Conditions: Refractive Errors

Summary: the purpose of this study is to compare the clinical performance of precision1™ contact lenses to clariti® 1 day contact lenses.

subjects will be expected to attend 3 study visits and wear the study lenses daily for at least 10 hours per day. on the day prior to visits 2 and 3, subjects will be expected to wear the study lenses for at least 16 hours. the total duration of subject participation will be up to 22 days.

Eligibility criteria:
key inclusion criteria * successful wearer of spherical soft contact lenses with at least 3 months wearing experience, with a minimum wearing time of 5 days per week and 10 hours per day. * possess spectacles and willing to wear habitual spectacles for vision correction when study lenses are not worn, as needed. * willing to wear contact lenses for at least 16 hours on one of the days (day prior to each week 1 visit). * other protocol-specified inclusion criteria may apply. key exclusion criteria: * habitual precision1, clariti 1-day, and dailies total1 contact lens wearers. * any monovision and multifocal lens wearers. * other protocol-specified exclusion criteria may apply.

Keywords: contact lenses disposable
urdu version of neck pain and disability scale (npad)

Conditions: Neck Pain; Neck Disorder

Summary: in this study, the examiners will investigate the reliability and validity of neck pain and disability scale in urdu language in pakistani patients with neck pain and related disability.

this study's objective is to translate the neck pain and disability scale (npad) into urdu and evaluate its reliability and validity in pakistani neck pain individuals. this cross-sectional survey will employ convenience sampling to choose participants. this study's findings will assist determine the npad's reliability and validity in individuals with neck pain and impairment. this scale's reliability will be evaluated utilising internal consistency and test-retest methods. cronbach's alpha value checks internal consistency. the interclass correlation will be used to examine the test-retest reliability.

Eligibility criteria:
inclusion criteria * individuals including both male and females between age 18 and 65 years. * participants with non-specific chronic pain of neck (\>3 months in duration). * individuals with sufficient knowledge and understanding of urdu language. exclusion criteria * individuals with history of cervical surgery. * individuals with cervical myelopathy or radiculopathy, regional tumors, disc herniation, vertebral fractures, traumatic injuries, cardiovascular and pulmonary diseases, pregnancy or any behavioral problems were excluded * individuals with any pertinent comorbidities including heart attack, cancer, cognitive impairment or infection were also excluded. herniation, vertebral fractures, traumatic injuries, cardiovascular and pulmonary diseases, pregnancy or any behavioral problems were excluded * individuals with any pertinent comorbidities including heart attack, cancer, cognitive impairment or infection were also excluded.

Keywords: neck pain and disability scale pain disability reliability and validity population with neck pain