Kornimate/medical-research-clean huggingface dataset:
optimization of the healing process of the uterine scar tissue after re-cesarean section

Conditions: Scar; Previous Cesarean Section; Complications; Cesarean Section, Wound, Dehiscence

Summary: this prospective, controlled, clinical, intervention study measures the number of uterine cesarean section scars and median myometrial thickness of women who underwent two cesarean sections six to nine months after their last cesarean section using transvaginal ultrasound. it is the purpose of the study to assess if a resection of the uterine scar from a previous cesarean section during a second cesarean section could lead to a decrease in risk for subsequent pregnancies.

the average number of cesarean sections in germany has doubled from 1991 to 2011, making up 32,1% of all deliveries in 2011. several studies describe instances in which pregnancies following a previous cesarean section were accompanied by complications such as life-threatening bleeding, placenta previa, placenta accreta, increta or percreta and dehiscence or uterine rupture. the risk of those complications increases further with the uterine scar tissue of a second cesarean section. today it is already common practice to resect uterine scars if the scar of a previous cesarean section becomes symptomatic, or when a non-symptomatic uterine rupture or serious dehiscence are discovered during a cesarean delivery. in this study all participants of the interventional group are examined via intraoperative ultrasound to identify the first uterine cesarean section scar and resect it completely. six to nine months after the resection participants will return for a one time follow-up. at this time, the investigators will measure the number of uterine scars and median myometrial thickness using transvaginal ultrasound. the results will be compared with those of two control groups, consisting of women who underwent either one or two cesarean sections without the intervention. the aim of the present study is to asses if the number of uterine scars and median myometrial thickness can be improved by the resection of the first uterine scar during a subsequent cesarean section. this will allow the investigators to draw conclusions regarding the benefit of routine resections of uterine cesarean section scars, and whether this practice could lead to a decreased risk for women undergoing two or more cesarean sections.

Eligibility criteria:
inclusion criteria: * 18 years or older * primary or secondary indication for cesarean section 6 to 9 months prior to the examination date exclusion criteria: * \<18 years old * current pregnancy * congenital deformity of the uterus * former surgery of the uterine myometrium

Keywords: cesarean section, repeat uterine scar tissue transvaginal ultrasound uterine rupture placenta accreta placenta percreta placenta increta
studying patterns in patient engagement among tardive dyskinesia patients

Conditions: Tardive Dyskinesia

Summary: the statistical analysis of the collected data aims to reveal the many factors that influence patient involvement in clinical trials. findings will be disseminated through conferences and scholarly papers to benefit all parties participating in clinical trials. these findings will help to shape the design of future clinical trials for people with tardive dyskinesia, as well as enhance recruiting techniques and retention rates.


Eligibility criteria:
inclusion criteria: * diagnosis of tardive dyskinesia * aged ≥ 18 years old and ability to provide written informed consent obtained prior to participation in the study and any related procedures being performed * no prior treatment for tardive dyskinesia exclusion criteria: * enrolled in another research study * inability to provide written informed consent * has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial

Keywords: tardive dyskinesia
a single center trial of donor site wound dressings after split thickness skin grafting.

Conditions: Donor Site Complication; Skin Graft Scar

Summary: the goal of this clinical trial\] is to compare different types of dressings used and there outcomes on stsg donor site wound. the main question\[s\] it aims to answer are: * the effectiveness of different donor site dressings and their adverse outcomes * the satisfaction of patients with the donor site dressing will be observed. participants will randomly allocated different types of dressings for split thickness skin graft donor site wound which include alginate hydrocolloid hydrofiber silicon film guaze


Eligibility criteria:
inclusion criteria: * . patients of aged 18 years and above of either gender underwent single donor-site wounds after split-skin grafting and surface area larger than 10 cm2 were included in the study exclusion criteria: * patients on chemotherapy or corticosteroids were excluded from the study. non-probability consecutive sampling was employed
efficacy and safety of dexlansoprazole mr and lansoprazole on healing of erosive esophagitis

Conditions: Esophagitis, Reflux; Esophagitis, Peptic

Summary: this is a study to assess the efficacy and safety of 8 weeks of treatment with dexlansoprazole modified release (mr)(60 mg daily and 90 mg daily) compared to lansoprazole (30 mg daily) in healing subjects with endoscopically proven erosive esophagitis.

this is a phase 3, randomized, double-blind, multi-center, active-controlled, 3-arm study with an 8 week treatment period. this study will compare the efficacy of dexlansoprazole mr (60 mg and 90 mg) with that of lansoprazole (30 mg) when administered orally as a single daily dose in the morning, before breakfast. the study is designed to evaluate healing of erosive esophagitis and the effect of the therapy on relieving gastroesophageal reflux disease related symptoms. the study consists of two periods, a screening period (maximum 21 days) and a treatment period, which will last up to 8 weeks.

Eligibility criteria:
inclusion criteria: * subject must have endoscopically confirmed erosive esophagitis as defined by the los angeles (la) classification grading system (a-d). exclusion criteria: * subject has a positive campylobacter-like organisms (clo) test for helicobacter (h.) pylori. * use of prescription or non-prescription proton pump inhibitors (ppis), histamine (h2) receptor antagonists or sucralfate, drugs with significant anticholinergic effects, misoprostol or prokinetics * use of antacids \[except for study supplied gelusil®\] * need for continuous anticoagulant therapy (blood thinners) * endoscopic barrett's esophagus and/or definite dysplastic changes in the esophagus * history of dilatation of esophageal strictures, other than schatzki's ring (a ring of mucosal tissue near the lower esophageal sphincter) * current or historical evidence of zollinger-ellison syndrome or other hypersecretory condition * history of gastric, duodenal or esophageal surgery except simple oversew of an ulcer * acute upper gastrointestinal (ugi) hemorrhage within 4 weeks of the screening endoscopy

Keywords: erosive esophagitis
polypropylene meshes in hernia repair

Conditions: Inguinal Hernias

Summary: the aim of this study was to analyze the shrinkage of two different screens in the repair of inguinal hernias in men . 32 patients with unilateral inguinal hernia were assigned randomly. a lichtenstein tension-free hernia repair was accomplished by emplacing heavy weight versus ultralight weight polypropylene meshes for repair of incisional hernia, marked next to the lips with six titanium clips (lt200).

eligibility criteria : elective surgery, men with unilateral inguinal hernia, 20 - 50 years exclusion criteria: bmi\> 30, recurrent inguinal hernia, strangulated inguinal hernia, anesthetic risk asa iii and iv, diabetics, copd, benign prostatic hypertrophy,cancer disease outcome: percentage of contraction of the different meshes by digital radiography in post-surgical days: 1, 30, 60 and 90 independent variables: age, bmi, smoking, ethnicity, profession

Eligibility criteria:
inclusion criteria: * elective surgery * men with unilateral inguinal hernia * age 20 - 50 years exclusion criteria: * bmi\> 30 * recurrent inguinal hernia * strangulated inguinal hernia * anesthetic risk asa iii and iv * diabetics * copd * benign prostatic hypertrophy

Keywords: inguinal hernia contraction of two different meshes in the repair of inguinal hernias in men
n-3 pufa and rheumatoid arthritis in korea

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to see if supplementation of n-3 polyunsaturated fatty acid (pufa) can be beneficial for the patients with rheumatoid arthritis.


Eligibility criteria:
inclusion criteria: * patients with rheumatoid arthritis diagnosed based on american college of rheumatology guideline and receiving nsaid, glucocorticoids, or dmard were eligible if the dosage had been stable for at least 3 months prior to entering the study. exclusion criteria: * patients were excluded if they were pregnant, lactating, under the age of 18 or over age 80, taking supplements containing n-3 pufa, white blood cell (wbc) ≤ 3.5 × 109/l, hemoglobin (hb) ≤ 8.5 g/dl, platelet ≤ 100 × 109/l, creatinine ≥ 2.0 mg/dl, and aspartate aminotransferase (ast) or alanine aminotransferase (alt) ≥ 2.5 times upper limit of normal.

Keywords: n-3 pufa rheumatoid arthritis inflammation eicosanoids bone turnover markers
laser used in the treatment of hypomineralized occlusal lesions in teeth enamel affected by mih

Conditions: Dental Enamel Hypoplasia

Summary: background: nowadays an increase in the incidence of teeth affected by molar incisor hypomineralisation (mih) has been observed. there are several treatment modalities that depend on the degree of severity of the defect, such as preventive procedures, restorative and even dental extractions. however, these changes may affect the retention and longevity of restorative materials. therefore, the aim of this study is to evaluate the use of diode laser irradiation for the treatment of occlusal surfaces of moderate lesions in permanent first molars affected with mih as a preventive method for dental caries and occlusal wear, besides verifying the discomfort of the treatment by patients. methods: for this, a controlled and randomized study, with parallel groups, will be conducted comparing the treatment with diode laser and sealing with high viscosity glass ionomer cement in the teeth affected by the mih. participants will be assessed at baseline and after 1 week, 1, 6, 12, 18 and 24 months. as the main outcome, the presence of dentin caries lesion and /or occlusal surface wear included in the study with dentin involvement will be evaluated. a visual examination for caries detection will be done using the icdas, using the index based on classification in the united states public health service - modified (usph) for evaluation of sealed teeth and impression of impacted teeth for quantitative analysis of the lesions. other outcomes such as patient satisfaction with treatment, patient discomfort, impact on quality of life and participant perception, as well as the duration and cost of treatment, as well as their cost-efficacy, will also be evaluated. multilevel statistical analyzes will be performed to verify the efficacy of diode laser treatment compared to sealing, in addition to possible factors associated with this efficacy.


Eligibility criteria:
inclusion criteria: * children who present at the first permanent molar with occlusal surface affected with light or moderate severity of mih * children between 6 and 10 years old exclusion criteria: * teeth that present restorations * teeth that presente sealants * enamel malformations that are specific to some syndromes * hypomineralized enamel affected by the ingestion of fluoride during enamel development

Keywords: lasers dental enamel hypoplasia preventive dentistry dental caries
peru longitudinal study

Conditions: Cardiovascular Diseases; Diabetes Mellitus; Hypertension; Dyslipidemias; Overweight and Obesity

Summary: the purpose of this study is to evaluate the change in disease prevalence over time in impoverished urban communities in lima, peru.

the aim is to track the changes in disease prevalence of people living in impoverished urban communities in lima over the next 10 years. based on data collected in prior years and in an ongoing manner, ohio university global health teams will be introducing interventions focused to positively impact disease states and trends in this population. the current focus is on chronic lifestyle related diseases and their precursors: cardiovascular disease, hypertension, dyslipidemia, diabetes, and overweight / obesity.

Eligibility criteria:
inclusion criteria: * minors age 12-17 presenting to the free community clinic, with a responsible adult who can give consent; minors will give assent. * consenting adults of any age who present to the clinic. exclusion criteria: * adults who are unable to give consent.
patient centered outcomes study

Conditions: Hernia, Ventral

Summary: several questions exist when looking at ventral hernias: 1. what is the baseline quality of life and abdominal wall function among patients with or without a ventral hernia? 2. what is the clinical significance of a ventral hernia seen on radiography but not on clinical examination (e.g. occult hernia)? 3. what is the natural history of quality of life of patients with and without a ventral hernia? 4. what is the impact of disclosure of presence or absence of a ventral hernia on quality of life? answering these questions can provide valuable information on the impact of surgery with or without subsequent ventral hernia on a patient's abdominal wall function and quality of life.


Eligibility criteria:
inclusion criteria: * adults age 18 years or older * patients at lbj hospital * patients who received a ct of the abdomen exclusion criteria: * children (under age 18 years old) * any patient in any vulnerable population (e.g pregnant women, prisoners, etc.)
prevalence study of amyloidosis in patients with surgery of suspect bilateral carpal tunnel (amylyoncarp)

Conditions: Carpal Tunnel Syndrome Bilateral

Summary: the purpose of this study is to evaluate the prevalence of amyloidosis in population of patient affected by suspect bilateral carpal tunnel with indication of surgery


Eligibility criteria:
inclusion criteria: * bilateral carpal tunnel with indication of surgery and judged suspect: * age of 50 years old and more * non-traumatic or undetermined neuropathic etiology or cardiac history (atrial arrhythmia or heart failure or cardiac stimulation) or family history of hereditary amyloidosis or monoclonal gammopathy exclusion criteria: * patient with diagnosis of amyloidosis * traumatic bilateral carpal tunnel or linked to rheumatoid arthritis
hyaluronic acid and polynucleotides for supra-bony defects

Conditions: Periodontal Diseases; Wound Heal; Periodontal Inflammation; Periodontal Pocket; Periodontal Attachment Loss

Summary: the goal of this pilot study is to describe the early wound healing molecular events and the vascularization pattern associated with the treatment of supra-bony defects with access flap alone or in association with a combined formulation of hyaluronic acid and polydeoxyribonucleotides gel.

this is a parallel-group, pilot study aiming that consists of 7 visits over a minimum period of 4 months. up to 24 periodontitis patients presenting with supra-bony defects will be recruited at the centre for oral clinical research (cocr) at the institute of dentistry, barts and the london school of medicine and dentistry, queen mary university of london, united kingdom.

Eligibility criteria:
inclusion criteria: * systemically healthy males and females ≥18 years old * stage iii or iv periodontitis (papapanou, sanz et al. 2018) * presence of supra-bony periodontal defects (i.e., defects where the base of the pocket is located coronal to the alveolar crest and characterized by a predominantly horizontal pattern of tissue destruction) confirmed clinically and radiographically at a minimum of two and a maximum of four adjacent teeth and with a probing pocket depth (ppd) \> 5 mm, following non-surgical periodontal therapy (nspt). if \>4 adjacent teeth exhibited the above clinical and radiographic conditions, the four adjacent teeth showing the greatest overall loss of periodontal attachment were included. wisdom teeth and second molars will not be considered for the study. if defect presents with an intrabony component, this should be ≤2 mm. * non-surgical periodontal treatment (step 1 and 2) completed within the previous 4 months * full-mouth bleeding score (fmbs) and full-mouth plaque score (fmps) ≤20% exclusion criteria: * teeth with degree iii mobility * multi-rooted teeth with grade ≥2 furcation involvement * heavy smokers (≥10 cigarettes a day) * untreated caries or endodontic lesions or abscesses on the teeth involved in the surgery * previous periodontal surgery in the area selected for the study * history of conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures (e.g., mitral valve prolapse, artificial heart) * antibiotic or anticoagulant therapy during the month preceding the baseline exam. * history of alcohol or drug abuse * medical history that includes uncontrolled diabetes or hepatic or renal diseases, or other serious medical conditions that can have a negative impact on the periodontal condition * in treatment with medications that can severely affect bone metabolism and blood clot formation (e.g., anticoagulants, long-term corticosteroids, bisphosphonates, immunosuppressants) * self-reported pregnancy or lactation.
comparison of outcomes in mobile and fixed-bearing total knee arthroplasty

Conditions: Osteoarthritis of Knee

Summary: the purpose of this study is to compare the clinical and radiological outcomes of mobile-bearing with that of fixed-bearing in total knee arthroplasty.

double blind, randomized prospective study mobile or fixed bearing of the same company * mobile bearing group : group m * fixed bearing group : group f inclusion criteria * patients expected primary total knee arthroplasty without severe deformity clinical outcomes * range of motion * complication * scorings * kss, ksfs, hss score, womac score, oxford score, sf-36 radiological outcomes * alignment angles in knee * positions of femoral and tibial components * position of patella * radiolucency

Eligibility criteria:
inclusion criteria: * primary total knee arthroplasty exclusion criteria: * infection * severe deformity in knee * revision

Keywords: total knee arthroplasty mobile bearing fixed bearing range of motion knee society score
the effect of obesity on endometrium in pcos

Conditions: Body Weight; Polycystic Ovary Syndrome

Summary: the effect of polycystic ovary syndrome (pcos) with or without obesity has received a few attentions. there is a lack of evidence to whether the bmi affects the endometrial blood flow, which is necessary for implantation.


Eligibility criteria:
inclusion criteria: * women with pcos are diagnosed according to rotterdam criteria, (rotterdam and asrm-sponsored, 2004)by the presence of two out of the following three: oligomenorrhea (absence of menses for 35-182 days) or amenorrhea (absence of menses for \>182 days), signs or symptoms of hyperandrogenism (acne, hirsutism), us showing polycystic ovaries. * fertile women had regular menstruation, with at least one previous spontaneous pregnancy. exclusion criteria: * women known to have hepatic or renal dysfunction, diabetes mellitus, hypertension, or cardiovascular disease. * if they have used induction of ovulation drugs for the last three months. * if they have used hormonal contraception in the last three months.

Keywords: endometrium
the effect of micro fragmented adipose tissue (mfat) on knee osteoarthritis

Conditions: Osteoarthritis, Knee; Knee Pain

Summary: this is a non-surgical trial comparing the clinical and functional outcomes of patients with osteoarthritis treated with intra-articular injection of micro fragmented adipose tissue versus conventional therapy of intra-articular injection of corticosteroid.

this study will be a randomized controlled trial to compare outcomes between intra-articular injection of micro fragmented adipose tissue and intra-articular injection of corticosteroid in patients with mild to moderate osteoarthritis of the knee. micro fragmented adipose tissue will be harvested at the subcutaneous tissue by lipoaspiration. once fat tissue is obtained, it will be processed with minimal manipulation in the clinic room. to be considered for participation in this study, patients must have radiographic evidence of mild to moderate osteoarthritis of medial and/or lateral weight-bearing compartments (kellgren-lawrence grade 2 or 3). in addition, patients must meet several inclusion/exclusion criteria to be randomized and included in this study.

Eligibility criteria:
inclusion criteria: * age between 35 and 75 years-old * diagnosis of pre-existing osteoarthritis of the joint by kellgren-lawrence grade 2 or 3. * working understanding of the english language and able to fully understand the procedure * capable of providing informed consent * able to complete online, in-person or phone surveys for the purposes of follow-up * capable of understanding pre- and post-procedure care instructions * ambulatory at baseline * previous trial and failure of conservative therapy consisting of a minimum of 6 weeks of physical therapy and trial of anti-inflammatory medications if not contraindicated, with or without concomitant bracing and/or injections. exclusion criteria: * age \ 75 years old * radiographs demonstrating either no, little or severe osteoarthritis (kellgren-lawrence grade 0, 1 ) * prior total or partial joint replacement surgery or a surgery involving cartilage regeneration (microfracture, aci, etc) * previous cortisone and/or hyaluronic acid intra-articular injection within the last 3 months * co-morbidity with rheumatologic condition, inflammatory arthritis * currently undergoing immunomodulatory therapy * uncontrolled endocrine disorder * bmi \>35 * current diagnosis of osteomyelitis, human immunodeficiency virus (hiv-1, -2) and/or hepatitis c (hcv), infection and poorly controlled diabetes (hga1c \>7.0) * pregnancy or planned pregnancy * previous stem cell injection into treatment joint * patient scheduled to undergo any concomitant surgical procedures. * coagulopathy or anticoagulant treatment * chronic pain involving multiple body parts or opioid medication management

Keywords: osteoarthritis stem cell knee pain adipose derived stem cell injection mfat micro fragmented adipose tissue
assessment of changes in labioincisal relationship in deep bite correction by twin slot orthodontic bracket clinical trial study.

Conditions: Percentage of Deep Bite Correction

Summary: assessment changes in labio incisal relationship in deep bite correction by twin slot orthodontic bracket; clinical trial study.

group(a): patients will be treated with double slot bracket with wire in incisal slot group(b):patients will be treated with double slot bracket with wire in cervical slot

Eligibility criteria:
inclusion criteria: * • mild to moderate deep bite. * permanent dentition stage (excluding the third molar) * age ranges from 16-23 years. * free from any medical or systemic condition that could interfere with * orthodontic treatment plane or effect on procedures. angle class1 or class11 malocclusion with minimal crowding. * female patient to avoide any sexual dimorphism which may affect the comparison. * good oral hygiene. * no previous orthodontic treatment. exclusion criteria: * uncooperative patient. * frequent missing appointments. * frequent broken appliance. * previous orthodontic treatments. * any systemic or bone diseases.