Kornimate/medical-research-clean huggingface dataset:
respiratory biofeedback sensor for yoga practice for youth with chronic pain.

Conditions: Pain, Chronic

Summary: this project will develop and test a wearable breathing monitor that will measure the synchrony in breathing between the diaphragm and chest of children with a pain diagnosis while receiving yoga therapy. specifically, we will develop a biofeedback system to help improve breathing in pain patients.

this small business technology transfer (sttr) phase i application proposes the development and trial of a novel non-invasive real-time breathing sensor - pneurip- to show the beneficial effects of respiratory biofeedback on yoga. pneurip will be employed to monitor and improve asana (posture) and pranayama (breathing) in yoga in youth with chronic pain. the sensor consists of two inductive bands worn around the chest and abdomen that measure and differentiate diaphragmatic and chest breathing through respiratory inductance plethysmography (rip). readings are recorded and analyzed on a small chest-worn unit and wirelessly transmitted to an ipad. measures include the phase angle between the chest and abdomen; percentage breathing through the ribcage; respiratory rate; and labored breathing index. this sensor takes little time to set up and readings are provided instantaneously. the first part of the proposal will develop the biofeedback software. the biofeedback component will be related to the synchrony between diaphragmatic and chest breathing, and the relative depth of breathing. this information will be presented to the user visually on an ipad screen in the form of 2 moving bars - one corresponding to the chest and one to the belly. in the second part of the study, we will test the pneurip with biofeedback with 20 youth with pain enrolled in an interdisciplinary pediatric chronic pain program in a large pediatric hospital receiving yoga as one of the therapies. the yoga regimen is 8 sessions, once per week. subjects will be randomized into two groups: one receiving instruction only on synchronous breathing; the second group will receive biofeedback in addition. outcome will phase angle between abdomen and ribcage (recorded during each session). outcomes will inform the feasibility of using real-time biofeedback in yoga with a non-invasive respiratory monitor.

Eligibility criteria:
inclusion criteria: * youth with chronic pain prescribed yoga therapy as part of treatment plan exclusion criteria: * otherwise healthy
the internet therapy for depression trial

Conditions: Chronic Pain; Major Depressive Disorder

Summary: the objective of this trial is to collect data on the feasibility, acceptability, and preliminary effectiveness of internet delivered cognitive beaviour therapy (icbt) and acceptance and commitment therapy (iact) interventions tailored towards the treatment of depression and chronic pain using a doubly-randomized, attention-controlled, non-blinded, patient-preference design.

the primary objective is to collect data on the feasibility, acceptability, and preliminary effectiveness of internet delivered cognitive beaviour therapy (icbt) and acceptance and commitment therapy (iact) on depressed mood among individuals with chronic pain relative to attention control (ac). the secondary objectives are to evaluate the efficacy of icbt and iact on clinically relevant outcomes endorsed by the initiative on methods, measurement, and pain assessment in clinical trials (immpact). adults with chronic non-cancer pain and major depression will be randomized to receive iact, icbt, or ac. the interventions comprise 7 weekly online modules available through therapist assisted online (tao). patients will be contacted weekly by a member of the study team who will be acting as their personalized "online therapy coach."

Eligibility criteria:
inclusion criteria: * fluent in english * 18 years of age or older * have a primary diagnosis of chronic non-cancer pain. * meet dsm-5 criteria for a diagnosis of major depressive disorder * have access to the internet, email, and telephone * can commit to the demands and timelines of the trial. * given high comorbidity in this population, patients with sleep disturbance or comorbid anxiety will also be eligible to participate. exclusion criteria: * diagnosis of cognitive impairment (e.g., dementia) * active suicidal ideation * severe psychopathology (e.g., schizophrenia) * unable to sign a safety contract for the duration of the trial * concurrent participation in psychotherapy.

Keywords: chronic non-cancer pain major depression internet therapies cognitive behaviour therapy acceptance and commitment therapy
the evaluation of the safety and effectiveness of a novel gel-type sodium hyaluronate for the correction of aging mid-face

Conditions: Dermal Filler; Hyaluronic Acid; Lidocaine; Aging Mid-Face

Summary: this study is to evaluate the safety and effectiveness for the correction of aging mid-face of treatment group compared with the negative control group.


Eligibility criteria:
inclusion criteria: 1. age 30 to 60 years of male or female 2. midface volume deficit scale (mfvds) of midface graded 2 to 5 by evaluator. exclusion criteria: 1. injection site with infection or other skin diseases present which may affect the evaluation 2. with medical history of chromatosis, discoloration, keloid formation, hypertrophic scarring at midface 3. with permanent implants or planning to receive permanent implants during the study period at the injection sites 4. hyaluronate facial dermal implant injection or other impermanent dermal fillers injection at injection sites within the past 6 months 5. with under-eye facial botox or fat injection within the past 6 months or planning to receive under-eye facial botox or fat injection during the study period 6. with major surgery 3 months before the start of the trial 7. with under-eye facial chemical or lasers peeling, non-invasive skin tightening, thermocool within the past 3 months or planning to receive these aesthetic procedures during the study period 8. with systemic immunosuppressive therapy or systemic corticosteroids within the past 2 months or planning to receive these therapies during the study period (subjects who have received inhaled/intranasal corticosteroids could be considered to include.) 9. with clinical meaningful coagulation disorders, underdoing anticoagulant treatment or within the past 10 days, or taking blood circulation promotion and blood stasis movement medications 10. with epilepsy or porphyria 11. with congenital or idiopathic methemoglobinemia or glucose-6-phosphate dehydrogenase deficiency 12. with analgesic dependence, analgesics within the past 2 weeks or planning to receive analgesics during the study period 13. with history of hypersensitivity or allergy to lidocaine, amide anesthetics, hyaluronic acid or any component of the device; gram-positive bacterial or streptococcus proteins; other severe hypersensitivity history unsuitable for participating in the study 14. planning to undergo any surgery which may cause significant body weight change (such as bariatric surgery) or take any medication which may cause significant body weight change 15. pregnant, planning pregnancy or in breastfeeding females 16. participated in clinical study of other device or drug and have not terminated within the past 30 days -other circumstances which judged to be unsuitable for participating in the study by the investigator
paravertebral block versus erector spinae plain block in percutaneous nephrolithotomy

Conditions: Renal Stone; Nephrolithiasis; Analgesia; Anesthesia

Summary: nowadays, percutaneous nephrolithotomy (pcnl) has been the surgical procedure of choice for renal stones larger than 2cm or staghorn stones. yet, the associated postoperative pain is a major drawback. the regional anesthetic management of pain in pcnl operation has been of great concern. the introduction of ultrasound guided erector spinae plane block and paravertebral plane block has been under great focus regarding the efficacy of postoperative pain management. paravertebral plane block (pvb) is a regional nerve block technique that depends on local anesthetic injection adjacent to the vertebra to block spinal nerve roots in a dermatomal distribution. erector spinae plane block (espb) is a newer regional anesthesia technique that depends on injecting local anesthetic (la) in a plane between the transverse process and erector spinae muscle. the la diffuses into the paravertebral space and spreads on both rami (dorsal and ventral) of spinal nerves through spaces between adjoining vertebrae. the aim of this study is to compare the effect of ultrasound guided paravertebral blockade versus erector spinae blockade on postoperative opioid use as well as postoperative pain control in patients undergoing unilateral pcnl.


Eligibility criteria:
inclusion criteria: * asa i - ii. * patients undergoing unilateral percutaneous nephrolithotomy (pcnl) surgery under general anesthesia. exclusion criteria: * patient refusal. * uncooperative patients. * allergy to local anesthetics. * infection or anatomical abnormality at injection site. * coagulopathy. * bilateral pcnl. * spinal anesthesia or any other regional anesthesia. * block failure: the block will be considered a failed block if the patient requires more than two doses of rescue analgesia in the first hour postoperatively.

Keywords: erector spinae plain block paravertebral block ultrasound-guided percutaneous nephrolithotomy analgesia
evaluation of a handwashing promotion program in chinese elementary schools

Conditions: Communicable Diseases

Summary: the purpose of this study is to determine the effects of a commercial hand washing promotion program on hygiene knowledge, attitudes, and practices, and on health outcomes such as reported infectious illnesses and school absences.

diarrheal and respiratory diseases cause 3.8 million deaths annually among children in the developing world. reduced rates of these diseases have been measured during intensive, home-based handwashing interventions. we evaluated a school-based handwashing program for 1st grade students to determine whether a more scalable intervention could also reduce illness rates, and impact hygiene knowledge and attitudes. thirty schools from each of 3 counties in fujian province, china, were randomized to one of the following groups: a) control; b) standard intervention, which included a handwashing program (1 hour of hygiene instruction and 1 soap sample kit per pupil); or c) expanded intervention, which included the handwashing program, soap for school sinks and 1 peer hygiene monitor per class. teachers collected illness symptom information from students weekly and recorded student absences daily between january and april, 2005. mean illness and absence rates were calculated for each school. students were given a knowledge, attitudes, and practices questionnaire before the intervention and again 5 months later.

Eligibility criteria:
inclusion criteria: * school has running water exclusion criteria: * school has not previously received commercial handwashing promotion program

Keywords: handwashing communicable diseases health education
carestream digital radiography long length imaging software data collection protocol

Conditions: Spinal Injuries

Summary: the study objective is to acquire composite images generated by the carestream long length imaging (lli) software and demonstrate that the images stitched using the carestream lli software and the images stitched using a approved predicate device are acceptable for clinical use.

the study consists of subject enrollment to collect images in a clinical setting, followed by a review of the stitched images by radiologists or qualified orthopedic surgeons to assess overall usability of the composite images. this study includes clinical data collection of individual (raw and processed) and composite dr images from a carestream device using alpha rotation to acquire the images. there is no subject involvement other than obtaining informed consent in order to use patient images and case record forms (crf), including supporting radiology reports. this study has no effect on clinical treatment and no foreseen risks to enrolled subjects. the predicate software is currently in place at the sites. carestream will harvest that data and reconstruct with investigational software offsite. a comparison reader study will be performed upon completion of data collection. please note this study is considered to be observational because there were no imaging of subject using investigational device. subjects requiring standard of care diagnostic images were exposed using the commercially available cedara system. the images captured on the cedara system were then re-processed using the carestream investigational software. subjects gave informed consent for carestream to reprocess their image data. they did not require any additional imaging using the investigational device.

Eligibility criteria:
inclusion criteria: * subject has provided informed consent * male or female who require long length imaging exclusion criteria: * not able or willing to provide informed consent, or consent is withdrawn * not able to collect all required case information * patients who are unable to stand * images which are not clinically acceptable to the user * images without a reference object such as a ruler in the image.
innovative stratification of arrhythmic risk (isar-trial): diabetes mellitus

Conditions: Myocardial Infarction

Summary: the purpose of this study was to evaluate the performance of established and new risk predictors in predicting mortality in post-infarction patients suffering from diabetes mellitus


Eligibility criteria:
inclusion criteria: acute myocardial infarction, presence of sinusrhythm exclusion criteria: -

Keywords: assessment, risk diabetes mellitus autonomic nervous system
feasibility of tee during cardiac arrest in dutch emergency departments

Conditions: Cardiac Arrest

Summary: the goal of this feasibility study is to learn if dutch ed providers are able to use transesophageal echocardiography during cardiac arrest. the main question it aims to answer is: • are the ed providers able to determine the area of maximal compression of the heart using tee

point-of-care ultrasound is a valuable diagnostic tool during cardiopulmonary resuscitation (cpr) in cardiac arrest and its use is recommended by international guidelines. transthoracic echocardiography (tte) is most commonly used, but has certain limitations. image acquisition can be challenging due to patient specific factors such as body habitus. also image quality may be impacted by the limited acquisition time during cpr pulse checks. furthermore, observational data suggests that pulse checks are prolonged due to tte, while minimizing interruption of chest compressions is emphasized for better cpr outcomes in the guidelines. transesophageal ultrasound (tee) is a possible alternative for tte. it has the theoretical advantage of superior image quality and thereby possible reductions of chest compression delays. furthermore, tee gives the opportunity determine which part of the heart is compressed most effectively, which is referred to as the area of maximal compression (amc). animal studies showed that an amc located over the left ventricle positively influenced hemodynamics and return of spontaneous circulation (rosc) compared to an amc over the aortic root. in human studies, data also suggests that amc located on the left ventricle, as measured by tee, may positively influence prognosis. in the netherlands, tee is currently not used in emergency departments during cardiac arrest. the purpose of this study is to investigate if point-of-care tee can be used effectively and safely by providers and teams that have not previously used this modality. given the paramount importance of quality of chest compressions, the ability of the providers to assess the location of the amc will be the main focus of this feasibility study.

Eligibility criteria:
inclusion criteria: * patients with cardiac arrest \> 18 year in the emergency department. exclusion criteria: * patients with known upper gastro-intestinal malignancy or strictures, previous upper gastro-intestinal surgery or radiation, or known esophageal varices. * patient with a do-not-resuscitate order, pregnant patients and traumatic cardiac arrest. * no trained tee provider available. * rosc at arrival. * decision by the team to stop resuscitation at arrival at the emergency department due of prognosis. * other life saving interventions which are prioritized over tee by the resuscitation team.

Keywords: transoesophageal echocardiography pocus emergency department
what are the effects of lower limb dysmetria on gluteus medius and erector spinae musculature?

Conditions: Muscular Disorders, Atrophic

Summary: gluteus medius (gm) has also been implicated in the development of low back pain (lbp). gm is one of the main pelvic, where he actively participates in control of motion in the frontal and transverse plane, and hip , improving stability to the lumbopelvic-hip complex. the aim of present study was to investigate whether modifying lower limb length with a different foot insoles of 0.5, 1 and 1.5 cm in a normal population has an effect on es and gm activity and as a consequence in lbp. as a secondary objective, in turn, to evaluate whether es and gm activity has an effect on jumping ability as assessed through cmj.

background: length leg discrepancy (lld), regardless of its origin, is a very common pathology that can contribute to low back pain. various authors point out its relationship with the lack of activation of both the gluteus medius (gm) and the ipsilateral erector spinae (es). the purpose of this study was to identify the activation of es and gm with different simulated lld, correlating said activation with the lbp. in turn, to evaluate whether es and gm activity has an effect on jumping ability as assessed through cmj. (2) method: a sample of healthy subjects was selected to whom an artificial lld was incorporated through a 0.5, 1 and 1.5 cm insole, measuring with emgs in these 3 moments while walking and performing a counter movement jump (cmj). the measurement was carried out in random order, in terms of insole height, using a latin square. muscle activation patterns were recorded for 30 seconds at each of the insole heights while walking at 5.7 km/h and compared with the maximum voluntary contraction (mvc), both on the ipsilateral and contra-lateral sides. these muscles were then measured under the same circumstances during the development of the cmj. (3)

Eligibility criteria:
inclusion criteria: - exclusion criteria: * the volunteers had no problems in range of motion of joints of the lower limbs * pelvic obliquity due to a functional leg length discrepancy. * obesity with body mass index (bmi) 35 \> kg/m²

Keywords: low back pain electromyography leg length inequality lower limb length
panitumumab (abx-egf) monotherapy in patients with metastatic colorectal cancer

Conditions: Colorectal Cancer; Metastases

Summary: the purpose of this study is to determine that panitumumab will have clinically meaningful anti-tumor activity in patients with metastatic colorectal cancer who have developed progressive disease or relapsed while on or after prior fluoropyrimidine, irinotecan and oxaliplatin chemotherapy.


Eligibility criteria:
inclusion criteria: * pathologic diagnosis of colorectal adenocarcinoma (diagnostic tissue obtained by tissue biopsy) * metastatic colorectal carcinoma * eastern cooperative oncology group of 0, 1 or 2 * documented evidence of disease progression during, or following treatment, with fluoropyrimidine, irinotecan and oxaliplatin chemotherapy for metastatic colorectal cancer * radiographic documentation of disease progression during or within 6 months following the most recent chemotherapy regimen is required * bidimensionally measurable disease * tumor expressing low to negative levels of epidermal growth factor receptor (egfr) by immunohistochemistry * at least 2 but no more than 3 prior chemotherapy regimens for metastatic colorectal cancer * adequate hematologic, renal and hepatic function exclusion criteria: * symptomatic brain metastases requiring treatment * patient with a history of interstitial pneumonitis or pulmonary fibrosis or evidence of interstitial pneumonitis or pulmonary fibrosis * use of systemic chemotherapy or radiotherapy within 30 days before enrollment * prior anti-egfr antibody therapy with the exception of the small molecule egfr tyrosine kinase inhibitors, which are permitted * prior anti-tumor therapies including prior experimental agents or approved anti-tumor small molecules and biologics of short (less than 1 week) serum half-life within 30 days before enrollment, or prior experimental or approved proteins within 6 weeks before enrollment

Keywords: colon, rectal cancer abx-egf, panitumumab, egfr immunex, abgenix, amgen metastatic colorectal cancer vectibix
electrical stimulation to strengthen muscles in the lower legs in patients requiring prolonged mechanical ventilation

Conditions: Muscle Weakness

Summary: the primary aim of this proposal is to test the effectiveness of nmes in improving functional status and muscle function in patients requirng prolonged mechanical ventilation


Eligibility criteria:
inclusion criteria: * duration of mechanical ventilation for 14 days or more * sufficiently awake * able to speak and comprehend english exclusion criteria: * known primary neuromuscular disease * lower extremities paresis or amputee * patients with left-ventricular assist device (lvad) * cardiopulmonary instability

Keywords: muscle strength muscle function functional status