Kornimate/medical-research-clean huggingface dataset:
dipeptidyl peptidase-4 inhibitor (dpp4i) for the control of hyperglycemia in patients with covid-19

Conditions: Hyperglycemia; Covid19

Summary: severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection has been a world health issue during the last months, affecting mostly countries with a high metabolic risk, like mexico. patients with type 2 diabetes (t2d) have an increased risk of any kind of infection as well as an increased mortality risk. hyperglycemia has been established as an important predictor of mortality in patients with t2d and sars-cov-2. the standard treatment of hyperglycemia in hospitalized patients has been basen on insulin schemes, but recently evidence suggest the utility of some other drugs, reducing the risk of hypoglucemia and increasing the probability of a proper metabolic control. the goal of this study is to compare the utility of dipeptidyl peptidase-4 inhibitor (dpp4i) as a combination with insulin on metabolic control and prognosis in hospitalized patients with sars-cov-2 and hyperglycemia.

severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection has been a world health issue during the last months, affecting mostly countries with a high metabolic risk, like mexico. patients with type 2 diabetes (t2d) have an increased risk of any kind of infection as well as an increased mortality risk. hyperglycemia has been established as an important predictor of mortality in patients with t2d and sars-cov-2. the standard treatment of hyperglycemia in hospitalized patients has been basen on insulin schemes, but recently evidence suggest the utility of some other drugs, reducing the risk of hypoglucemia and increasing the probability of a proper metabolic control. dpp4 enzyme has an ubiquitous distribution and has been considered as a pro-inflammatory enzyme, considering that dpp4 inhibitors could have and anti-inflammatory effect, as it has been shown in different works. the goal os this study is to compare the utility of dpp4 inhibitor as a combination with insulin on metabolic control and prognosis in hospitalized patients with sars-cov-2 and hyperglycemia. for this purpose we will randomize patients with sars-cov-2 and hyperglycemia to receive either the combination of dpp4i + insulin or insulin alone and will follow al algorithm treatment to define metabolic control as well as prognosis.

Eligibility criteria:
inclusion criteria: * hospitalized patients with confirmed infection by sars-cov-2 * hyperglycemia higher than 140 mg/dl * patients accepting oral medications * both sex * older than 18 years of age * patients who accept to participate in the study and sign the consent form exclusion criteria: * type 1 diabetes * pregnancy * hyperosmolar hyperglycemic state or diabetic ketoacidosis
safety and efficacy study to compare two rosacea treatment regimens

Conditions: Rosacea

Summary: to compare the safety and efficacy of two treatment regimens: 1) col-101 and metronidazole gel 1%; 2) doxycycline hyclate 100 mg and metronidazole gel 1%

compare the safety and efficacy of two treatment regimens: 1) col-101 and metronidazole gel 1%; 2) doxycycline hyclate 100 mg and metronidazole gel 1%

Eligibility criteria:
inclusion criteria: * 8-40 total lesions * erythema * telangiectasia exclusion criteria: * non-pregnant, non-lactating * achlorhydric * gastric by-pass surgery * allergy to study medications * drug/alcohol abuse * use of proton pump inhibitors

Keywords: rosacea
nutrient nutritional advise for low back pain patients seeking chiropractic care

Conditions: Low Back Pain; Nutrition Poor

Summary: the nutritional intervention will reduce lbp and cause 10% weight loss.

this feasibility study will assess a two-armed low-back pain (lbp) randomized, prospective clinical trial with nutritional offerings provided for one-arm.

Eligibility criteria:
inclusion criteria: bmi 25-40, experiencing lbp (vas\>4, mechanical, chronic), not pregnant exclusion criteria:

Keywords: chiropractic manipulation spinal manipulation therapy osteopathic manipulation
lenvatinib plus i-125 seed brachytherapy vs. lenvatinib for tace-refractory hcc

Conditions: Hepatocellular Carcinoma Non-resectable

Summary: this study is conducted to evaluate the efficacy and safety of lenvatinib plus iodine-125 seed brachytherapy (len-i) compared with lenvatinib (len) alone for patients with hepatocellular carcinoma (hcc) refractory to transarterial chemoembolization (tace).

this is a single-center, prospective and randomized controlled trial to evaluate the efficacy and safety of len-i versus len alone for patients with tace-refractory hcc. 187 patients with tace-refractory hcc will be enrolled in this study. the patients will receive either len-i or len alone using an 2:1 randomization scheme. lenvatinib (body weight ≥ 60 kg, 12mg p.o. qd; body weight \< 60 kg, 8mg p.o. qd) will be administered to the patients and last until disease progresses, intolerable toxicity, withdrawal of informed consent, loss of follow-up, death, or other circumstances that require termination of treatment, whichever occurs first. for patients in the len-i arm, iodion-125 seeds will be implanted into the the target lesions (viable intrahepatic tumor and/or vascular tumor thrombus) under ct guidance according to the pre-operative planning within 7 days after lenvatinib administration. iodion-125 seeds implantation can be repeated on demand during follow-up based on the evaluation of laboratory and imaging examination. the primary end point of this study is overall survival (os). the secondary endpoints are progression-free survival (pfs), time to progression (ttp), objective response rate (orr), disease control rate (dcr), and adverse events (aes).

Eligibility criteria:
inclusion criteria: * hcc confirmed by histopathology and/or cytology, or diagnosed clinically * diagnosis of hcc with tace refractoriness according to the criteria proposed by japan society of hepatology (2021) * patients who have tumor recurrence after surgical resection or ablation are allowed to be included * at least one measurable intrahepatic target lesion * child-pugh class a/b * eastern cooperative oncology group (ecog) performance status of 0 or 1 * life expectancy of at least 3 months exclusion criteria: * extrahepatic metastasis * tumor thrombus involving main portal vein or both the first left and right branch of portal vein * vena cava invasion * patients who received prior systemic therapy, immunotherapy, hepatic arterial infusion chemotherapy (haic) or radiotherapy for hcc * history of organ and cell transplantation * history of bleeding from esophagogastric varices * history of hepatic encephalopathy * hematologic examination: platelets \<50×10\^9/l * prothrombin time prolongation ≥ 4s * severe organ (heart, lung, kidney) dysfunction * history of malignancy other than hcc

Keywords: hepatocellular carcinoma lenvatinib iodion-125 seed
a pilot study analyzing reproductive results after iui using vitrified human sperm

Conditions: Infertility

Summary: the aim of this study is to assess the evaluate the effectiveness of vitrified donor semen in intrauterine insemination treatments.

sperm cryopreservation is an efficient procedure widely used in fertility clinics, that provides logistical flexibility and increases the potential for success in assisted reproduction. it has been demonstrated that reproductive rates are comparable when using frozen sperm or fresh semen. however, sperm freezing using standard protocols is inevitably associated with a loss of motility, membrane integrity, and other post-thaw sperm quality parameters due to what is known as cryodamage, which involves the formation of intracellular ice crystals, osmotic shock, and dehydration. sperm vitrification has been recently developed as an improved alternative, where freezing occurs extremely rapidly (-20,000 ºc/min). consequently, the formation of intracellular ice crystals is reduced, leading to improvements in sperm motility, vitality, and integrity. however, the use of vitrified semen in fertility clinics is scarce, and no study has addressed whether vitrification could affect reproductive outcomes, such as live birth. the aim of this study is to assess the evaluate the effectiveness of vitrified donor semen in intrauterine insemination treatments through the analysis of clinical pregnancy (primary objective) and as secondary objectives the number of progressive sperm post-thaw, percentage of progressive sperm and biochemical pregnancy.

Eligibility criteria:
inclusion criteria: * patients undergoing artificial insemination with sperm from donor. * female partner's age \< 35 years * first iui attempt * caucasian phenotype exclusion criteria: * any adverse medical condition that may significantly affect reproductive outcomes

Keywords: intrauterine insemination sperm cryopreservation sperm vitrification
comparison of caudal block and sacral erector spinae block for postoperative analgesia

Conditions: Postoperative Pain; Children, Only

Summary: caudal block (cb) has been the method used for years to achieve adequate postoperative analgesia in pediatric patients, which is one of the main responsibilities of an anesthetist. cb, which has been proven to provide effective analgesia for many different indications, is the most commonly performed neuraxial block technique for postoperative pain control in urogenital surgeries. however, in the following years, truncal nerve blocks are recommended for postoperative analgesia by the literature both for more effective analgesia and for preventing complications of cb that may prevent early mobilization and prolong hospital discharge

circumcision, which is widely performed in male children for cultural and religious reasons in our country, is one of the daily urological surgical procedures with painful postoperative period. however, in the following years, truncal nerve blocks are recommended for postoperative analgesia by the literature both for more effective analgesia and for preventing complications of cb that may prevent early mobilization and prolong hospital discharge. based on this knowledge, in order to provide postoperative analgesia in urogenital surgeries in male children sacral esp (sesp) block can be used as an alternative to cb due to its undesirable effects

Eligibility criteria:
inclusion criteria: * 1-7 years of age * asa (american society of anesthesiologists) i-ii group * scheduled for circumcision * able to communicate in turkish * willing to participate to the study (parents and children) exclusion criteria: * less than 1 or more than 7 years of age * a neurological deficit, bleeding diathesis, or a history of local anesthetic allergy; an infection or redness in the injection area, congenital lumbar anomaly, liver and/or kidney disorder, a psychiatric disorder, mental retardation, or communication problems detected during examination * unwilling to to participate to the study ((parents or children)

Keywords: ultrasound pain sacral erector spinae block caudal block
epidemiology of sleep disturbances among the adult population of the sao paulo city

Conditions: Healthy

Summary: sleep disturbances are of great relevance within the context of public health as they affect a sizable portion of the population with far reaching consequences. many automobile and labor accidents as well as poor school and work performance can be traced to sleep disturbances, which are also linked to cardiovascular disease, metabolic syndrome, and psycho-cognitive alterations. objectives: 1. establish the epidemiologic profile of sleep disturbances among the adult population of the city of sao paulo in 2007; 2. investigate associations between sleep patterns and disturbances in that population, taking into account the following variables: social-demographic status, anthropometrics, clinical, activity/rest cycle, eating and physical activity habits, mood disturbances, sexual dysfunction in males, alcoholism, drug addiction, genetic markers, biochemical, hematological, endocrine, immunologic and inflammatory indicators; 3. assess the compatibility of the results collected in the current study with those of epidemiologic sleep investigations of said city carried out in 1987 and 1995 with the aim of determining the secular sleep disturbance trend. methods: the two-stage cluster randomized sample included 1100 individuals of the city of sao paulo, representing the population proportionally to gender, age groups and social classes. data were amassed as follows: 1. the application of home and institution questionnaires; 2. description of the sleep patterns and disturbances through polysomnography and actigraphy, performed at the sleep institute; 3. collection of peripheral blood for biochemical, hematologic, endocrine and genetic assays. statistics: subsequent to double typing (inputting) and analysis of data consistency, descriptive and analytical statistical assessments will be performed with the aim of describing patterns of sleep disturbances associated to the explanatory variables under investigation. in the light of bi-varied analysis, predictive/explanatory multivaried models were adjusted.


Eligibility criteria:
inclusion criteria: * both genders aged 20 to 80 years and living in private households in the city of são paulo. exclusion criteria: * pregnant or lactating women * people with physical or mental impairment: and * workers in night shifts.

Keywords: general population
post-acute physician home visit program

Conditions: A Patient Discharged From an Acute-care Hospital Who Had an Acute Illness

Summary: new or worsening symptoms following discharge from the hospital likely leads to unplanned readmission. these rates are higher than desired and costly to patients, payers, and providers. many interventions have unsuccessfully attempted to reduce readmissions, but few have provided in-home personnel to patients transitioning from acute care back to ambulatory care. still fewer have involved a physician in the home. we therefore will test the effect of a physician home visit to a patient's home who was discharged in the last 4 days.


Eligibility criteria:
inclusion criteria: * resides within either a 5-mile or 20-minute driving radius of brigham and women's hospital (bwh) or brigham and women's faulkner hospital (bwfh) emergency room * has capacity to consent to study * \>=18 years old exclusion criteria: * undomiciled * in police custody * domestic violence screen positive
comparison of cervical motion restriction and interface pressure between two cervical collars

Conditions: Cervical Pain

Summary: cervical orthoses are used to restrict motion for the purpose of preventing spinal instability following trauma or pre- and post-surgery or to protect from pain. modern cervical orthoses are able to effectively restrict motion of the head however load is concentrated on areas of occipital tissue and may, with long term wear, lead to tissue breakdown in the form of pressure ulcers. previous research has shown that the miami j collar (össur americas foothill ranch, ca) effectively reduced cervical movement while providing superior pressure relief. as new cervical orthoses are developed and become commercially available it is useful to examine their performance in comparison to existing well-tested devices. djo global (vista, ca) have recently developed a cervical collar. the purpose of this study is to compare the ability of this newly developed collar to restrict cervical range of motion while at the same time limit the tissue interface pressure exerted by the collar on patients when they are in an upright seated or supine position data will be collected in a fully equipped 3d motion analysis laboratory. cervical range of motion will be tracked and analyzed. interface pressures between the head and collar will be measured using custom pressure mats.


Eligibility criteria:
inclusion criteria: * english speaking. * subjects who have read and signed irb approved informed consent for this study. exclusion criteria: * history of neck pain or neck injury requiring medical care within the previous 12 months. * history of spinal surgery, physical or chiropractic therapy of the neck. * history of cervical spondylosis or osteoporosis. * pregnant. * currently incarcerated

Keywords: neck pain cervical collar
acute and chronic effect of his-pacing in consecutive patients with av-block

Conditions: Atrioventricular Block

Summary: conventional right ventricular (rv) apical pacing may result in asynchronous ventricular contraction with delayed left ventricular activation, interventricular motion abnormalities, and worsening of left ventricular ejection fraction. his pacing is preserving a synchronous contraction and may prevent a decrease in left ventricular ejection fraction. hypothesis: his-pacing preserves left ventricular function and is a feasable alternative compared to rv septal septal pacing in patients with av-block.

conventional right ventricular apical pacing may result in asynchronous ventricular contraction with delayed left ventricular activation, interventricular motion abnormalities, and worsening of left ventricular ejection fraction. his pacing is preserving a synchronous contraction and may prevent a decrease in left ventricular ejection fraction. the aims of our crossover, double-blinded, randomized study is to evaluate the feasibility and long-term safety of permanent his pacing and to compare the effects on left ventricular ejection fraction of permanent his pacing with those of conventional right septal stimulation after 12 months treatment in patients with 2nd or 3rd degree av-block.

Eligibility criteria:
inclusion criteria: * 2nd or 3rd degree av block exclusion criteria: * qrs \> or = 120 ms * indication for cardiac resynchronization therapy (crt) or implantable cardioverter defibrillator (icd) * chronic atrial fibrillation * pregnant * expected heart surgery \< 2 years * expected survival \> 2 years * patients that have been his ablated * serious comorbidity

Keywords: his-pacing
observational study of mircera in users of self-application and multidose systems

Conditions: Renal Anemia of Chronic Kidney Disease

Summary: this non-interventional, observational study investigates the efficiency, safety and acceptance of mircera in participants, who received erythropoiesis stimulating agent (esa) using a self-application system. for each participant, the investigator documents 9 months of treatment with mircera with respect to efficacy, safety and acceptance.


Eligibility criteria:
inclusion criteria: * anemia caused by ckd only * life expectancy of more than (\>) 9 months in the judgment of the attending physician * ferritin \>200 micrograms per liter (mcg/l) in accordance with the relevant guidelines * the time point of changing to mircera was only 3 months ago at the longest exclusion criteria: n/a
university of pittsburgh brain health initiative

Conditions: Traumatic Brain Injury

Summary: this project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical, neuroimaging, and biomarker measures.


Eligibility criteria:
inclusion criteria: former professional football player/exposed group: 1. professional football retiree aged 29-59 2. played a minimum of 3 professional football seasons, with a minimum of 3 games in each season 3. fluent in english (translations are not available/validated for most neuropsychological tests) control/unexposed group: 1. age 29-59 male 2. high school education or beyond 3. fluent in english (translations are not available/validated for most neuropsychological tests) exclusion criteria: control/unexposed group: 1. played organized football beyond high school 2. history of severe tbi 3. current unstable cardiovascular disorder for both groups: 1. prior history of psychosis (such as schizophrenia), or other major neurological disorder that would interfere with testing, in the opinion of the primary investigator. 2. contraindication to mr imaging, such as ferrous metal, pacemakers, or concerns about claustrophobia

Keywords: brain health football contact sport concussion
epidural volume extension and intrathecal use of local anesthetics in cesarean sections

Conditions: Stillborn Caesarean Section

Summary: intrathecal (i.t.) administration of isobaric bupivacaine, ropivacaine and levobupivacaine with addition of fentanyl for c-section either combined or not with administration of 10 ml of n/s 0,9% epidurally, in order to extent epidural space.sensory and motor block profile, haemodynamics and side effects were assessed.

parturients scheduled for elective caesarean section are randomly allocated to 6 groups: they receive double-blindly intrathecal isobaric bupivacaine 10 mg ( group b), ropivacaine 15mg (group r) , levobupivacaine 10mg (group l) combined with 10 μg fentanyl and followed by epidural administration of 10 ml of n/s 0,9% respectively, and isobaric bupivacaine 10 mg ( group bupivacainef), ropivacaine 15mg (group ropivacainef) , and levobupivacaine 10mg (group levobupivacainef) combined with 10 μg fentanyl without epidural administration of 10 ml of n/s 0,9%. clinical endpoints are the sensory and motor block profile, haemodynamics (arterial pressure, heart rate) and side effects.

Eligibility criteria:
inclusion criteria: * elective cesarean section * asa i-ii exclusion criteria: * complicated pregnancy (i.e preeclampsia, eclampsia,arterial hypertension, diabetes mellitus) * abnormal fetal heart rate at the time of admission * body mass index \> 35 kg/m2 * height \ 185 cm * age \ 40 yrs * patients with contraindication to spinal anaesthesia( i.e anticoagulants) * asa \>iii * intraoperative excessive bleeding * patients with previous psychiatric diseases

Keywords: parturient