Kornimate/medical-research-clean huggingface dataset:
effect of individualized training versus non-individualized training to improve quality of life of sedentary employees

Conditions: Exercise; Healthy Volunteers; Health; Quality of Life

Summary: the practice of a physical activity, even moderate, plays an important role in the prevention and the management of the main chronic non-communicable diseases (cardiovascular diseases, certain cancers, diabetes, obesity, osteoporosis ...) as well as by improving psychological health. several studies have shown that physical activity has a positive impact on the economy of companies via the reduction of absenteeism and the improvement of productivity. however, it seems important to individualize these recommendations in order to prescribe the best possible dose of physical activity for each individual. in this project, the investigators want to test the physical qualities of employees in order to prescribe the best possible dose of physical activity with the ultimate goal of improving quality of life.

physical activity (pa) is one of the major determinants of health. indeed, the practice of a physical activity, even moderate, plays an important role in the prevention and the management of the main chronic non-communicable diseases (cardiovascular diseases, certain cancers, diabetes, obesity, osteoporosis ...) as well as by improving psychological health. the effects are beneficial regardless of age, gender and state of health. moreover, in addition to the well-being of employees, several studies have shown that physical activity has a positive impact on the economy of companies via the reduction of absenteeism and the improvement of productivity. today, the world health organization (who) prescribes 150 min of physical activity per week regardless of the person's profile (active employee, employee working in his office, construction worker, etc.).. in this project,the investigators therefore want to test the physical qualities of employees in order to prescribe the best possible dose of physical activity with the ultimate goal of improving quality of life.

Eligibility criteria:
inclusion criteria * sedentary people * affiliate to health care organism * subject who gave their consent exclusion criteria: * people with degenerative disease * pregnant women * cardiovascular trouble * subject who are not able to understand the proceeding of the study or to give their consent

Keywords: sport parallel physiopathology physical activity prescription
safety and bioefficacy of vitamin d2 and vitamin d3

Conditions: Vitamin D Deficiency

Summary: the aim of this study is to investigate the bioavailability of vitamin d2 and d3 as measured by the increase of the specific hydroxy forms in serum (25(oh)d2 and 25(oh)d3, respectively, and by total 25(oh)d.

study design: human volunteers will receive supplements containing either vitamin d2 or d3 for a period of 8 weeks. at baseline, after 4 weeks and after 8 weeks, 25(oh)d2, 25(oh)d3 and total 25(oh)d will be measured in serum as the main outcome variables. additional outcome variables are the ca concentration in serum, pth concentration in serum, ambulatory blood pressure and heart rate, and renin expression in peripheral mononuclear cells. groups/cohorts assigned interventions 1. placebo group 2. vitamin d2-group daily treatment with vitamin d2-supplements (containing 2000 iu per capsule) 3. vitamin d3-group daily treatment with vitamin d3-supplements (containing 2000 iu per capsule)

Eligibility criteria:
inclusion criteria: * 18 years * healthy exclusion criteria: * supplementation of vitamin d and calcium * hypercalcemia * hypercalciuria * chronical illness (diabetes, kidney diseases, cardiovascular diseases) * serum-creatinine above 115 mmol/l * pregnancy or breastfeeding women

Keywords: randomized controlled trial vitamin d bioavailability
sourdough bakery products and digestive function

Conditions: Dyspepsia

Summary: in a double-blind, randomised crossover study, two sourdough croissants (sc) or two brewer's yeast croissants (bc) were served to 17 (9 f; age range 18-40; bmi range 18-24 kg/m2) healthy subjects to evaluate the effects of their ingestion on postprandial gastrointestinal functions. hydrogen breath test was performed to measure h2 production after sc and bc ingestion. gastric volume was evaluated by magnetic resonance(mr) imaging to calculate gastric emptying rate in the 3-hour interval following croissant ingestion. palatability and postprandial gastrointestinal symptoms and perceptions over a 4-h period after the meal were evaluated by visual analogue scale (vas). in addition, in the 3-hour interval, blood samples were drawn to measure serum glucose levels. the area under the curve (auc) was employed to evaluate global kinetics of all parameters and the t-test was used to evaluate differences between groups.

in this monocentric study, a double-blind, randomised crossover design was used, with washout periods of at least one week between study days. a standardized meal consisting of two 100 g croissants prepared with sourdough or with brewer's yeast was administered randomly to 17 (9 f; age range 18-40; bmi range 18-24 kg/m2) healthy subjects after an overnight fast (at least 8 h) and consumed in a 10-minute interval with 300 ml of water. immediately after meal ingestion, subjects were asked to evaluate croissant palatability. gastric volume was evaluated by magnetic resonance(mr) imaging to calculate gastric emptying rate in the 3-hour interval following croissant ingestion. hydrogen breath test was performed to assess gastrointestinal fermentation measuring h2 production after sc and bc ingestion. postprandial gastrointestinal symptoms and perceptions over a 4-h period after the meal were evaluated by visual analogue scale (vas). in addition, in the 3-hour interval, blood samples were drawn to measure serum glucose levels. the protocol was repeated twice in each subject, once with sourdough croissants (sc) and once with brewer's yeast croissants (bc), dispensed according to a computer generated randomisation list created by rc following simple randomisation procedures (computerized random numbers). the area under the curve (auc) was employed to evaluate global kinetics of all parameters and the t-test was used to evaluate differences between groups.

Eligibility criteria:
inclusion criteria: * age ranging between 18 and 40 yrs * normal-weight (body mass index 18-24.9 kg/m2), exclusion criteria: * smoke * functional or organic gastrointestinal disease * gluten allergy * dyslipidemia * diabetes * psychiatric disorders * claustrophobia * pregnancy * breast-feeding

Keywords: sourdough; leavening process; fermentation; brewer's yeast
[68ga] nota-sgc8 in the staging of bladder cancer

Conditions: Bladder Cancer

Summary: the goal of this clinical trial is to test the imaging and diagnostic ability of \[68ga\]-nota-sgc8 pet/mr in bladder cancer patients with different stages. the main questions it aims to answer are: * tumor specific lighting ability of \[68ga\]-nota-sgc8 in bladder cancer patients with different stages. * the safety of \[68ga\]-nota-sgc8. participants will be irrigated with \[68ga\]-nota-sgc8 into the bladder for tumor imaging under pet/mr. the imaging performance of \[68ga\]-nota-sgc8 on different stages of bladder tumors will be systematically evaluated by combining with pathological sections of patients. urine accumulation and radioactivity distribution of \[68ga\]-nota-sgc8 will be measured. the adverse events will be recorded.

participants will be irrigated with \[68ga\]-nota-sgc8 intravesically, with 0.05mci/kg per person per time according to body weight, no more than 5mci. the participants will be instructed to urinate cleanly before irrigation, and then irrigated \[68ga\]-nota-sgc8 into the bladder via catheter for 30 minutes to make full contact between the injection and tumor. after 30 minutes, the injection will be withdrawn and 300ml normal saline will be injected into the bladder to maintain the shape of the bladder. to evaluate the efficacy of \[68ga\]-nota-sgc8 in imaging bladder tumors, the following indexes will be measured: specific imaging of the tumor area; specific imaging of its target ptk7 receptor protein; distribution in major organs; pet/mr imaging after administration; the absorbed dose of internal radiation based on the reference human hormone model using olinda software. tumor tissues of patients will be collected, and pathological sections of relevant patients will be analyzed after surgery. immunohistochemistry will be used to verify the expression of ptk7 receptor in corresponding tumors. the association between ptk7 receptor protein and tumor malignancy, invasion, and stage will be evaluated by molecular imaging results. all adverse events will be recorded within 24 hours after the administration of \[68ga\]-nota-sgc8. serious adverse events will be recorded for all subjects within 24 hours to 5 days after intravesical infusion. blood and urine samples will be collected and the concentration of 68ga-nota-sgc8 in the blood and urine will be analyzed.

Eligibility criteria:
inclusion criteria: * patients with newly diagnosed or previously diagnosed bladder tumors. * at least one cystoscopy was performed within one month prior to enrollment, and the clinical diagnosis of bladder tumor was present. * age \> 18 years, \< 80 years * patients voluntarily participate and sign informed consent and are willing and able to follow protocol requirements. exclusion criteria: * pregnancy, lactation, severe liver and kidney insufficiency and children; * participants who are allergic to the experimental drug, have an allergic disposition, or are allergic to multiple drugs.

Keywords: bladder cancer [68ga]-nota-sgc8 pet/mr bladder irrigation
italian version of the oxford elbow score score

Conditions: Elbow Disease; Patients Reported Outcomes; Elbow Surgery

Summary: validation of the cross-cultural adapted italian version of the oxford elbow score, in order to have an instrument able to detect the functional state reported by patients after elbow surgery.

an italian version of the oxford elbow score has been created by an experts committee, according to the published guidelines for the cross-cultural adaptation of self-reported measures. the new version of the questionnaire will be administered to a sample size of 120 patients, in addition to meps, quick dash and sf-36 questionnaires during the follow-up apointments at 2 and/or 6 months after elbow surgery in two orthopaedic clinic in north italy. reliability, validity , reproducibility and responsiveness will be detected by questionnaires.

Eligibility criteria:
inclusion criteria: * ability to speak and understand italian, * need for one-elbow surgical procedure any elbow disease. exclusion criteria: * injury in more than one musculoskeletal district
microbial adhesion and biofilm formation on denture base materials

Conditions: Inflammatory Response; Microbial Colonization; Denture Stomatitis

Summary: polymethylmethacrylate (pmma) has been the material of choice for fabricating complete dentures for more than 80 years now.(1,2) as a material it is easy to handle and can be easily repaired and polished. pmma while being a low-cost material has good esthetics. some disadvantages of pmma as a material are surface roughness and porosities which lead to staining, plaque accumulation and bacterial adhesion over time. among the various factors that can influence microbial attachment to surfaces, surface roughness, hydrophilicity and free surface energy of pmma are most important. carboxylate and methyl ester groups found in pmma make it a very hydrophilic material with a large amount of free surface energy. despite the influence of the chemical composition, processing methods play the most important role in developing surface roughness.

pmma for dentures may be processed by conventional techniques like compression moulding or injection moulding with the conventional pack and press technique being considered the 'gold standard' when it comes to processing methods as it has successfully withstood the test of time. with the advent of technology cad/cam milling is now being used to mill dentures from pre-polymerized blocks of acrylic resin. at the same time 3d printing/rapid prototyping technology is also being used to print denture bases with acrylic resins. both these technologies eliminate the need for conventional flasking and processing methods. the rapid prototyping technique involves serial apposition of resin layers on a custom designed support structure. these layers are hardened by curing with either visible light, uv light, heat or laser depending upon the technique used. this process is repeated until the designed structure is completely formed. the milling or subtractive technique on the other hand uses pre-polymerized commercially manufactured pmma blanks (pucks) which are made under high pressure. this technique allows for the material to have superior mechanical properties. in reviewing the literature, no clinical studies were performed to compare which method of pmma denture construction can reduce the amount of microbial colonization while there are a lot of invitro studies was performed.

Eligibility criteria:
inclusion criteria: * completely edentulous populations. * good physical and mental health. * no systemic disease exclusion criteria: * partially edentulous populations. * patients with smoking more than 10 citrates day. * patients with systemic diseases. * patients undergrown radiotherapy.

Keywords: microbial adhesion, biofilm formation, denture base
non-invasive cardiac output monitor (nicom) for goal-directed fluid resuscitation for inpatients with hypotension and/or septic shock

Conditions: Sepsis; Hypotension; Septic Shock

Summary: the non-invasive cardiac output monitor (nicom) is a non-invasive monitor capable of measuring cardiac output (co) and cardiac index (ci), and stroke volume (sv) and stroke volume index (svi) based on heart rate. conceptually nicom is a technology that utilizes a dynamic response characteristic in assessing the need for fluid administration, whereby svi is measured before and after a fluid challenge with more fluid given only if svi increases significantly with administered fluid. dynamic response technologies are intended to replace older, "static" measures such as central venous pressure (cvp) and pulmonary capillary wedge pressures (pcwp) which are single point measurements utilized to assess the need to administer fluid. the aim is to pilot and evaluate the effectiveness of using the non-invasive cardiac output monitor (nicom) technology for goal-directed fluid resuscitation in adult inpatients with sepsis associated acute hypotension and/or evidence of septic shock (lactate \>= 4.0).


Eligibility criteria:
inclusion criteria: * all adult patients \> 18 years of age * inpatients for \>/= 6 hours * meeting criteria for sepsis as defined by hypotension related to sepsis (map \< 65 or sbp \< 90) or evidence of septic shock (lactate ≥ 4.0). exclusion criteria: * patients who die within 24 hours of hospital admission * patients documented as "comfort cares" or enrolled in "general inpatient hospice" during the first 72 hours of hospitalization. * opted out of having their medical information used in research, as noted in the ehr.
expanding rural access: distance delivery of support groups (main study)

Conditions: Depression; Breast Cancer; Stress; Breast Cancer Non-invasive Breast Cancer; Breast Cancer Early Stage Breast Cancer (Stage 1-3); Breast Cancer Metastatic Breast Cancer

Summary: the study will answer two questions about women with breast cancer in rural communities: 1. will they find this support group format utilizing videoconferencing acceptable and rewarding? 2. will they report a greater sense of emotional and informational support, and less depression and traumatic stress, than the control groups of women who wait to participate until after the first groups have ended?


Eligibility criteria:
inclusion criteria:to be eligible to participate, a woman must meet all of the following criteria: 1. be a resident of one of nine rural counties in northeastern california (modoc, plumas, siskiyou, shasta, lassen, trinity, sierra, nevada, and tehama), 2. be able to travel to a rural health facility included in the northern sierra rural health network to participate in videoconferencing meetings; 3. be able to speak and read english well enough to be able to read, discuss, and comprehend the consent form; 4. be 21 years of age or older; 5. have been diagnosed with breast cancer by a physician; and 6. who (in the judgment of the local coordinator) is not unduly distressed or otherwise not able to participate effectively in a support group. women will be included with any stage of breast cancer as our pilot study demonstrated that in these rural communities, women wanted to include women with any stage of breast cancer in their groups. also, our pilot study results showed that it worked fine to include women regardless of the period elapsing since they received their diagnosis, as our pilot study results showed that some women with a long period of time elapsing since receiving their diagnosis were still in need of a source of social support for coping with having had this experience and felt that they had a lot of help to offer women who had more recently received a breast cancer diagnosis. the 9 counties were selected because they are among the most remote counties in california, yet they have strong primary care systems in place, and most patients receive specialty care in-state, as opposed to out-of-state. every effort will be made to include women of ethnic minority groups. the support group facilitator, community advisory board (cab) members, and the local community coordinators will also be recruited for the interviews, with informed consent, identified by having played one of these roles for this study. exclusion criteria:potential participants who do not meet all of the inclusion criteria listed above will be excluded.
the impact of pulmonary rehabilitation on dyspnea in chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: dyspnea (respiratory discomfort) and activity limitation are the most common symptoms of chronic obstructive pulmonary disease (copd) and contribute importantly to a perceived poor quality of life. recent international guidelines have stressed the importance of dyspnea alleviation and improvement exercise tolerance as a means of enhancing quality of life and other long term outcomes in this population. modern pharmacotherapy is the first step in symptom management but the overall impact of bronchodilator therapy is relatively small. exercise training remains the most effective treatment for ameliorating dyspnea and improving exercise endurance and was the main focus of this study. the main objectives of the study were: 1. to conduct and compare detailed studies of respiratory mechanics during cycle exercise before and after exercise training (ext) compared with an untrained control group. by multiple regression analysis, the investigators will establish the main contributors to dyspnea relief after ext. 2. to compare the magnitude of change in endurance during constant work rate cycle exercise with those measured during walk tests and the endurance shuttle walk test after ext relative to control. to evaluate which test (constant work rate cycle, six-minute walk test, or endurance shuttle walk test) is the most sensitive test for measuring changes in endurance after ext versus control. 3. to compare the change in standardized dyspnea ratings (borg scale) during constant-load cycling with a variety of other activity-related dyspnea questionnaires. to evaluate which of these measurements is the most sensitive for examining changes in perceived discomfort during exercise. 4. to evaluate the contribution of psychological factors (anxiety, fear, respiratory panic, self-efficacy) to the perceived improvement of symptoms following ext. the investigators will use multiple regression analysis to examine associations between changes in perceived dyspnea and changes in anxiety and self-efficacy measured by validated questionnaires and borg intensity ratings?


Eligibility criteria:
inclusion criteria: * diagnosis of copd * clinically stable * presence of activity-related dyspnea (baseline dyspnea index \< 9) * 40-80 years of age exclusion criteria: * other significant disorders or diseases that could interfere with conduct of the intervention or tests * body mass index \ 40 kg/m2

Keywords: copd dyspnea exercise measurement respiratory physiology
prevalence and impact on qol from ototoxicity in cancer survivors

Conditions: Hearing Loss, Sensorineural; Tinnitus, Subjective; Cancer; Chemotherapeutic Toxicity

Summary: this study will involve collaborating with oncologists in the post-chemotherapy follow-up appointments. the participants who wish to consent to this study will then answer 3 short questionnaires (thi, hhia and sf-36) about hearing loss, tinnitus and quality of life. the audiologist or the researcher, under the supervision of an audiologist, will then perform a simple, non-invasive hearing test on the participant. should the participant have a hearing loss, they will be advise to seek help from their general practitioner.

there has been a substantial increase in cancer survival rates in the the past decades, however many cancer survivors are now impacted by the multitude of toxicities associated with treatment. it is only when temporary toxicities subside that the long-term toxicities progress and become important. chemotherapy, although highly effective, is known to cause ototoxicity, presenting as hearing loss and tinnitus. hearing loss and tinnitus are associated with a higher risk of depression, dementia, social isolation and anxiety. there is little information and support offered to patients who suffer from ototoxicity, which can potentially lead to many being undiagnosed and untreated. ototoxicity can be permanent and progressive, therefore it is essential that a deeper understanding and increased awareness of how hearing loss and tinnitus affects the quality of life (qol) of cancer survivors can improve long-term symptoms management and support offered. this project aims to identify the prevalence and severity of long-term ototoxicity in cancer survivors following platinum-based treatment. prevalence of ototoxicity can be unreliable and varies in the medical literature, with studies reporting rates between 24% and 79%. information on prevalence will be achieved by recruiting patients from oncology clinics and performing a high frequency audiogram. the results from the audiogram will be compared to an normative dataset in addition to detecting self-reported hearing loss from the hearing handicap inventory for adults (hhia) and the hearing handicap inventory for elderly (hhie) questionnaires. furthermore, the severity and prevalence of tinnitus will also be detected by using the tinnitus handicap inventory (thi) questionnaire. a validated questionnaire assessing qol (sf-36) after cancer will also be completed by the patients. the questionnaires will be statistically analysed and compared against a dataset from the general population in the hope to identify the concerns surrounding long-term ototoxicity in cancer survivors.

Eligibility criteria:
inclusion criteria: * ability to give informed consent * age 18+ at time of cancer diagnosis * at least 1 cycle of any type of platinum-based chemotherapy * 0-5 years following first cycle of platinum-based chemotherapy * comprehensive understanding of the english language exclusion criteria: * previous radiotherapy to the head and neck area * pre-existing hearing deficits