Kornimate/medical-research-clean huggingface dataset:
molecular prediction of development, progression or complications of kidney, immune or transplantation-related diseases

Conditions: Acute Kidney Injury; Chronic Kidney Diseases; Solid-organ Transplantation; Cancer; Metabolic Disease; Immune Diseases

Summary: managing patients with renal failure requires an understanding of the molecular mechanisms that lead to its occurrence (i.e. upstream of the disease), its worsening and its persistence (i.e. downstream), while also specifying the risk of worsening renal failure (risk stratification, intolerance to the treatment or complications (infectious, metabolic, cardiovascular, cancer...). nephrogene 2.0 aims to study these different components of kidney, immune and solid organ transplantation (sot)-related diseases.

acute renal failure (arf) and chronic kidney disease (ckd) are frequent pathologies (850 million people are affected worldwide). renal failure is associated with an increased morbidity and mortality, including an increased risk of infections, drug toxicity and cardiovascular death. the causes of renal failure are numerous: metabolic (diabetes, hypertension), immunological (autoimmune diseases, monoclonal gammopathies), toxic (environment, drugs), genetic, infectious, ischemic, paraneoplastic... any episode of arf is also accompanied by a risk of secondary ckd (relative risk multiplied by 9). the mechanisms leading to renal failure are multiple and combine predisposing genetic factors, inadequate intra-renal or systemic immune response, endothelial and epithelial dysfunctions, and potentially inappropriate regenerative capacity. in addition, renal failure or its treatment itself may be accompanied by additional renal lesions (e.g. nephrotoxicity of calcineurin inhibitors used as anti-rejection treatment in transplantation, hemodynamic intolerance with secondary arf during hemodialysis sessions, iatrogenic arf when using diuretics or inhibitors of the renin angiotensin system) or extra-renal complications (e.g. immunosuppression and infections induced by immunomodulatory therapies during autoimmune diseases or for prevention of transplant rejection; vascular diseases secondary to phosphocalcic disorders). patients included in the nephrogene 2.0 cohort will be followed during 10 years and clinical data and biological samples will be collected at the inclusion in the cohort, at each monitoring programmed in their usual care and and at each event (infection, acute kidney injury, cancer...). samples will be collected according to the symptoms of the patients.

Eligibility criteria:
inclusion criteria: * patients (\> 18 year of age) with kidney disease or at risk to develop a kidney disease, * patients followed by a practitioner of the department of nephrology and organ transplantations of the university hospital of toulouse (france) exclusion criteria: * consent deny * inability of the patient or its family to give consent.

Keywords: risk stratification solid-organ transplantation cancer chronic kidney disease acute kidney injury
drinking habits of glaucoma patients and age matched controls

Conditions: Dehydration; Glaucoma

Summary: the purpose of this study is to examine if a chronic dehydration is a risk factor for the developement or progression of some forms of glaucoma.

glaucoma patients who are hospitalized for diurnal intraocular pressure measurements and glaucoma assessment are asked about their drinking habits. objective evaluation of hydration status is assessed with the body composition monitor (fresenius). retinal vessel analysis and laser doppler flowmetry are investigated in subgroups. the control group are also hospitalized patients who do not suffer from glaucoma.

Eligibility criteria:
inclusion criteria: * glaucoma patients * controls exclusion criteria: * psychiatric disease, * epilepsy, pregnancy, * nutritional disorder, * malfunction of blood clotting and wound healing, * pacemaker, * metallic stents

Keywords: dehydration risk factor glaucoma controls
safety of breast conserving treatment in locally advanced breast cancer receiving neoadjuvant treatment

Conditions: Breast Cancer

Summary: the study explores the safety of breast conserving treatment (bct)(defined as complete removal of tumor deposits) after neoadjuvant treatment for locally advanced breast cancer.

the standard breast surgical procedure of locally advanced breast cancer in norway is mastectomy. there is increasing interest in performing breast conserving treatment (bct) in locally advanced cases after chemotherapy or hormonal treatment - if there is a partial or complete clinical remission. to increase the evidence for the safety (no residual tumor) of such a procedure directly compared to mastectomy without compromising the safety of the treatment, a breast preserving procedure followed by an immediate mastectomy can be performed within a study. it would then be possible to study the margins after the breast preserving procedure as well as the tumor status in the rest of the breast. patients included in the study will receive neoadjuvant treatment followed by evaluation of the tumor reduction by magnetic resonance imaging (mri) and selection of bct candidates. candidates will be prepared for bct, and during the surgical procedure, bct will be performed (as one surgical specimen) followed by immediate removal of the rest of the breast tissue (mastectomy). the bct specimen and mastectomy specimen will be analysed for residual tumor cells. the tumor removal completeness of the bct procedure can be evaluated, with comparison to the clinical and primary tumor characteristics, including analysis of the tumor biopsies and imaging before and during the neoadjuvant treatment, for selection of candidates for bct in the future.

Eligibility criteria:
inclusion criteria: * patients with locally advanced breast cancer (ct3-4c, n0-3) with tumors \> 5 cm, as determined by mri, where the present guidelines include them for neoadjuvant systemic therapy * written informed consent (informed consent document to be approved by the independent ethics committee) prior to study-related procedures and examinations. * female age \> 18 years * able to comply with the protocol * histologically confirmed adenocarcinoma of the breast * american society of anesthesiologist's physical status category 1 or 2 before surgery. category 1 and 2 includes healthy patients and patients with only mild systemic disease, whereas category 3 includes patients with more serious systemic diseases (but still operable). exclusion criteria: * inflammatory breast cancer or diffuse locoregional involvement of the skin * stage iv - metastatic disease * locoregional relapse of earlier breast cancer * inability (irrespective of reason) to receive the recommended neoadjuvant treatment, - as decided by the treating physician. * american society of anesthesiologist's physical status category 4-5

Keywords: breast cancer locally advanced neoadjuvant treatment breast conserving surgery
study on gynecological laparoscopy under total intravenous anesthesia

Conditions: Butorphanol

Summary: to investigate the effect of preemptive analgesia with tartaric acid butorphanol on postoperative pain in gynecological laparoscopy under total intravenous anesthesia with remifentanil.this randomised, double-blind, placebo-controlled trial enrolled 60 patients undergoing elective gynaecological laparoscopy. the patients were divided into two groups: the butorphanol group (n = 30) and the control group (n = 29). both groups received tiva with propofol and remifentanil. observing two groups of patients on the visual analog scale, the total consumption of rescue analogies, and the confidence of postoperative nausea and vomiting (ponv), and the patient satisfaction score.

to investigate the effect of preemptive analgesia with tartaric acid butorphanol on postoperative pain in gynecological laparoscopy under total intravenous anesthesia with remifentanil.this randomised, double-blind, placebo-controlled trial enrolled 60 patients undergoing elective gynaecological laparoscopy. the patients were divided into two groups: the butorphanol group (n = 30), who received 0.02 mg/kg of tartaric acid butorphanol intravenously 30 minutes prior to anaesthesia induction, and the control group (n = 29), who received the same volume of normal saline. both groups received tiva with propofol and remifentanil. the primary outcome was the visual analogue scale (vas) score for pain at rest and on movement at 1, 2, 4, 6, 12 and 24 hours after surgery. the secondary outcomes were the total consumption of rescue analgesics, the incidence and severity of postoperative nausea and vomiting (ponv), and the patient satisfaction score.

Eligibility criteria:
inclusion criteria: * women patients, aged 18-65 years, with an american society of anesthesiologists physical status of i or ii * undergoing elective gynaecological laparoscopy for benign diseases exclusion criteria: * patients who had an allergy or contraindication to any study drug * had chronic pain or opioid use * had a history of substance abuse or psychiatric disorders * were pregnant or lactating * had a severe cardiovascular, respiratory, renal, hepatic or haematological disease * had a body mass index \>30 kg/m2 * had an inability to understand or cooperate with study procedures

Keywords: analgesia remifentanil postoperative pain
krill oil and muscle in older adults

Conditions: Aging; Sarcopenia

Summary: the aim of this study is to determine the effects of krill oil supplementation on muscle mass in function in older adults. half of the participants will receive krill oil supplements and the other half a placebo.


Eligibility criteria:
inclusion criteria: * bmi less than 35kg/m2 exclusion criteria: * diabetes * severe cardiovascular disease * seizure disorders * uncontrolled hypertension (\>150/90mmhg at baseline measurement) * cancer or cancer that has been in remission \<5 years * ambulatory impairments which would limit ability to perform assessments of muscle function * dementia * taking medication known to affect muscle (e.g. steroids) * have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump) * on anticoagulant therapy * allergies to seafood * regular consumption of more than 2 portions of oily fish per week.
assessment of efficacy of vardenafil, influence on self-esteem and self-confidence in subjects with erectile dysfunction

Conditions: Erectile Dysfunction

Summary: erectile problems may lead to anxiety, loss of self-esteem and depression and/or stress. the purpose of this national study was to determine if vardenafil is effective in treating impotent men (erectile dysfunction) and evaluate its influence in self-esteem and self-confidence. during the visits the patients was asked some questions about erections, and he fill different questionnaires about sexuality, mood, feelings, self-esteem and sexual activity.


Eligibility criteria:
inclusion criteria: * age: 18 years and older * males with erectile dysfunction * stable heterosexual relationship exclusion criteria: * primary hypoactive sexual desire- history of myocardial infarction, stroke or life-threatening arrhythmia within the prior 6 months * nitrate use * other exclusion criteria apply acc. to summary of product characteristics

Keywords: erectile dysfunction vardenafil
establishment of normal breast epithelial cell lines from patients at high risk for breast cancer

Conditions: Breast Neoplasm; Hereditary Neoplastic Syndrome

Summary: women who are at high risk for breast cancer, either because of linkage to high risk breast and ovarian cancer families, or because of a carcinoma in the opposite breast, will be studied. women will have a physical examination and mammography to ensure that no breast abnormalities are present. eligible women will undergo biopsy of the breast to obtain normal breast tissue. short-term cell cultures will be established from this tissue and early passages of the short-term cell lines will be stored. a bank of high risk normal mammary epithelial cells will be established. to further characterize the mammary epithelial cells in this population of women, cell cultures will subsequently be analyzed for their growth and metabolic properties, sensitivity to chemopreventive agents, steroid receptor characteristics, oncogene expression and regulation, and genetic changes.

women who are at high risk for breast cancer, either because of linkage to high risk breast and ovarian cancer families, or because of a carcinoma in the opposite breast, will be studied. women will have a physical examination and mammography to ensure that no breast abnormalities are present. eligible women will undergo biopsy of the breast to obtain normal breast tissue. short-term cell cultures will be established from this tissue and early passages of the short-term cell lines will be stored. a bank of high risk normal mammary epithelial cells will be established. to further characterize the mammary epithelial cells in this population of women, cell cultures will subsequently be analyzed for their growth and metabolic properties, sensitivity to chemopreventive agents, steroid receptor characteristics, oncogene expression and regulation, and genetic changes.

Eligibility criteria:
women at high risk for breast cancer, either because they are a member of a high risk breast or ovarian cancer family, or because of a carcinoma of the opposite breast. normal mammogram within past 3 months. no suspicious breast or axillary lesions on physical examination. no major cardiopulmonary, hepatic or renal disorders.

Keywords: brca-1 familial breast cancer breast cell culture high risk
improving hand recovery with neuromodulation in tetraplegia

Conditions: Spinal Cord Injuries; Tetraplegia, Unspecified, Incomplete, Chronic

Summary: this study will examine a form of non-invasive brain stimulation applied with intensive therapy of the arm and hand. the goal of the study is to determine if arm and hand function can be improved in people with incomplete cervical spinal cord injury (neck spinal cord injury, tetraplegia). participants will be assigned to receive either active or inactive non-invasive brain stimulation.

this study will look at the effects of a painless, non-invasive form of brain stimulation, called transcranial direct current stimulation, or tdcs. tdcs is thought to increase the brain's ability to change. participants will be assigned to one of two groups by chance. one group will receive tdcs at a level expected to increase the brain's ability to change, while the other group will receive tdcs at a level not thought to affect the brain's ability to change. all participants will receive intensive therapy of their more impaired arm and hand, focusing on exercises that are meaningful to him/her.

Eligibility criteria:
inclusion criteria: 1. traumatic, incomplete cervical sci sustained at neurological level c4-c7 and classified as b, c or d by the american spinal injury association impairment scale (ais); 2. sustained injury at least 1 year prior to enrollment (i.e., chronic); and 3. men and women between the ages of 18-65. exclusion criteria: 1. history of head injury, seizures, severe alcohol or drug abuse, or psychiatric illness; 2. cognitive deficits severe enough to preclude informed consent; 3. positive pregnancy test or being of childbearing age and not using appropriate contraception; 4. presence of ferromagnetic material in the cranium except in the mouth, including metal fragments from occupational exposure and surgical clips in or near the brain; 5. decubitus ulcers that might interfere with intervention; 6. cardiac or neural pacemakers; 7. fixed ue contractures; 8. untreated depression; 9. concurrent participation in occupational therapy; 10. within 3 months of recruitment, an addition or change in the dosage of drugs known to exert detrimental effects on motor recovery.

Keywords: neuroplasticity rehabilitation transcranial direct current stimulation transcranial magnetic stimulation activities of daily living motor training
a study to learn about the occurrence of adhd in adults with mental conditions and their quality of life

Conditions: Attention Deficit Hyperactivity Disorder (ADHD)

Summary: the main aim of the study is to find out how frequently adults with at least one psychiatric condition have adhd (but have not been diagnosed with adhd before) and to describe the quality of life of these adults who have been diagnosed with adhd. to find out how often adhd is not diagnosed in these adults could provide awareness about this condition and could help to improve preventing underdiagnosis.


Eligibility criteria:
inclusion criteria: part i: * adult greater than or equal to (\>=)18 years of age or canadian adult \>=19 years of age * ability to consent, as judged by the study investigator * diagnosis of at least one psychiatric disorder of at least 12 months duration, based on international classification of diseases (icd)-10 codes registered in electronic health records * consecutive assessment for adhd (as per routine clinical practice) * able to read and write in the first language of the respective country part ii * inclusion in study part i * diagnosis of adhd during part i, according to routine diagnostic procedure and algorithms * anticipated availability for being followed over 9 months exclusion criteria: part i: * diagnosis of any of the following at any time prior to signing informed consent: schizoaffective disorder, intellectual disability, or other cognitive disorders * occurrence of any of the following events within the 6 months prior to signing consent: psychotic episodes, acute intoxication, or psychotropic drug withdrawal syndrome. * diagnosis of adhd at any time before study inclusion * serious and unstable medical condition (severe disease that limits survival to 1 year) * participation in a clinical interventional trial in the 12 months prior signing consent part ii: - participant being followed-up for adhd in a different site
relaxation effects of personalized breathing exercises for healthy college students

Conditions: Breathing Exercises

Summary: stress plays a major role in the etiology and pathogenesis of anxiety and depression. relaxation therapies, such as breathing exercises, can reduce stress and increase relaxation. this study has two aims. first, it aims to personalize and optimize breathing protocols. second, it aims to tailor breathing protocols to subgroups based on prediction models of expected efficacy. three different breathing protocols, varying solely in their instructed breathing frequency with 40 percent (a), 60 percent (b), and 80 percent (c) of the interindividual spontaneous breathing frequency, are tested in a randomized, counterbalanced crossover trial. other parameters, such as breathing quality (i.e., nasal and diaphragmatic), rhythm (i.e., prolonged exhalation without instructed pauses) and depth (i.e., increased depth due to slower breathing frequency) as well as contextual factors (e.g., posture, video-based instructions, type of pacer, etc.) are invariant between protocols. first, this study hypothesizes a difference in the relaxation response between breathing protocols a, b, and c. this study looks at the relaxation response from three different angles (1) self-report, (2) autonomic arousal, and (3) central nervous system arousal. second, this study explores prediction models of expected efficacy based on the interindividual variance in characteristics (i.e., depressive, anxious and stress symptoms as well as expertise in relaxation therapies) and biomarkers (e.g., heart rate variability, peripheral temperature, skin conductance, etc.). prediction models can tailor breathing protocols to subgroups to increase expected efficacy.


Eligibility criteria:
inclusion criteria: * above 18 years old * university student * native german speaker exclusion criteria: * any psychiatric (e.g., anxiety), neurologic (e.g., epilepsy) or cardio-pulmonary (e.g., asthma) diagnosis

Keywords: relaxation therapy stress-management breathing exercise stress anxiety depression
problem solving therapy for prostate cancer spousal caregivers

Conditions: Prostate Cancer

Summary: problem-solving therapy programs have been shown to be effective among parents of children diagnosed with cancer. efforts have been made to apply this same strategy to spouses/significant others of men diagnosed with prostate cancer. the purpose of this study is to test the efficacy of problem-solving therapy on the spouses of prostate cancer patients.

problem-solving therapy programs have been shown to be effective among parents of children diagnosed with cancer. efforts have been made to apply this same strategy to spouses/significant others of men diagnosed with prostate cancer. the purpose of this study is to test the efficacy of problem-solving therapy on the spouses of prostate cancer patients. participants were randomly assigned to an experimental group which received problem-solving therapy, or to a control group which relied on their standard methods of coping (e.g. their normal therapist, family and friends). participants completed baseline surveys regarding their distress and coping prior to randomization. they then completed these surveys again at post-intervention (approximately 2-3 months post-baseline) and 6 months post-baseline to determine lasting effects of the intervention.

Eligibility criteria:
inclusion criteria: * diagnosed with prostate cancer within 18 months of study enrollment. * the patient and significant other cohabited * couples resided in san diego county * both patient and significant other were sufficiently proficient in english exclusion criteria: -

Keywords: caregivers coping skills
analgesic efficacy of fascia iliaca compartment block compared with intrathecal nalbuphine for hip surgery under spinal anesthesia

Conditions: Postoperative Pain

Summary: it is already known that fascia iliaca compartment block and intrathecal nalbuphine are very effective ways in postoperative pain control in patients having hip surgeries.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) score (asa i- asa ii). * age ≥ 21years. * body mass index \< 35 kg/m2 exclusion criteria: * patient's refusal. * known coagulopathy. * known peripheral neuropathy or neurological deficits. * known allergy to study drugs
the effect of auditory disturbances on human movement

Conditions: Healthy; Pain

Summary: this study sets out to investigate the potential effect of auditory disturbances on human movement

clinicians routinely investigate/test human movement but if/how this is effect by auditory disturbances is unclear. this study sets out to investigate the impact of auditory disturbances on human movement.

Eligibility criteria:
criteria: inclusion criteria: - healthy participants * pain free healthy participants * able to speak, read and understand danish and english exclusion criteria: - healthy participants * pain from the neck, back, arm or leg during the past 6 months up to the test session * former surgery in neck, back, arm or leg restricting normal movement * current or previous chronic or recurrent pain condition * pregnancy * current or previous neurologic, musculoskeletal or mental illnesses * lack of ability to cooperate inclusion criteria: - pain population * self reported ongoing or recurring pain from neck, back, arm or leg * able to speak, read and understand danish and english exclusion criteria: - neck pain population * current or previous chronic or recurrent pain condition * former surgery in neck, back, arm or leg restricting normal movement * pregnancy * current or previous neurologic, musculoskeletal (other than what is included) or mental illnesses * lack of ability to cooperate