Kornimate/medical-research-clean huggingface dataset:
ultrasound guided diuretic therapy in type 1 cardiorenal syndrome

Conditions: Cardiorenal Syndrome Type 1

Summary: a double-blind, randomized, controlled trial was conducted with the main objective of evaluating if patients with clinical assessment and vexus reach decongestion faster within a maximum period of 7 days during the hospital stay. likewise, the study will describe those patients who experience a decrease in serum creatinine (crs), nt-probnp at discharge, greater diuretic adjustment, rate of intrahospital readmission, and 30-day mortality.


Eligibility criteria:
inclusion criteria: * 18 years old or older * type 1 cardiorenal syndrome in emergency room at instituto nacional de cardiologia ignacio chávez exclusion criteria: * patients who denied to participate * liver disease (cirrohsis) * complex congenital heart disease * kidney transplant * heart transplant * severe valvular disease * chronic kidney disease kdigo g5 and g5d * intermacs score 2
reliability of mri and ultrasound in cervical epidural needle depth estimation

Conditions: Chronic Neck Pain; Radicular Pain; Cervical Epidural Injection

Summary: this study aims to evaluate the reliability of magnetic resonance imaging (mri) and ultrasound (usg) in predicting needle depth during cervical epidural injections, compared to fluoroscopy. the goal is to identify alternative imaging methods that reduce radiation exposure while maintaining procedural accuracy and patient safety.

cervical epidural steroid injections (cesi) are commonly used to manage chronic neck and radicular pain. accurate needle placement is critical for the success and safety of the procedure. fluoroscopy is the standard method for guiding the needle; however, it exposes patients and clinicians to ionizing radiation. this study compares pre-procedural mri and usg measurements of needle depth with fluoroscopy-guided needle depth during cesi. primary objective: assess the agreement between mri, usg, and fluoroscopy measurements of needle depth using intraclass correlation coefficients (icc) within a ±0.3 cm tolerance. secondary objectives: evaluate the correlation between fluoroscopic lateral imaging frequency and radiation exposure. the study is a methodological observational study conducted at ankara etlik city hospital, involving adult patients undergoing cesi. data will be collected retrospectively and prospectively for eligible participants.

Eligibility criteria:
inclusion criteria: age ≥ 18 years, diagnosed with chronic cervical pain, referred for cervical epidural steroid injection, patients capable of providing informed consent. exclusion criteria: age \< 18 years, pregnancy or breastfeeding, history of coagulation disorders or use of anticoagulants, severe systemic infections or local infections at the injection site, known allergy to steroids or local anesthetics, uncontrolled diabetes mellitus, patients with spinal tumors or significant spinal deformities, previous cervical spine surgery, cognitive impairment preventing informed consent or follow-up participation.

Keywords: cervical epidural steroid injection needle depth estimation ultrasound guidance mri guidance fluoroscopy radiation exposure chronic pain management
comparison between dexcom g5 mobile continuous glucose monitoring (cgm) system and the freestyle libre flash glucose monitoring system

Conditions: Type 1 Diabetes Mellitus

Summary: 1. the accuracy of the sensors (dexcom g5 vs freestyle libre flash glucose monitoring) will be evaluated by simultaneous wearing of the 2 sensors during 2 weeks. during these 2 weeks the patients will do at least four capillary blood glucose measurements to compare with the sensor results. 2. patient satisfaction will be evaluated using a questionnaire that will be completed after the dexcom g5 sensor has been worn for 1 month. 3. the data recorded by the freestyle libre flash glucose monitoring system (average glucose,% above target, % within target, % under target, amount of hypoglycemia) in the month prior to the 2 weeks of double sensor wear will be compared to the same data recorded by the dexcom g5 mobile cgm system during the first month of use.


Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus * treated by insulin injections exclusion criteria: * other types of diabetes * treated with insulin pump

Keywords: diabetes mellitus child glucose sensor accuracy usability
n6 input processing in traditional ci recipients

Conditions: Hearing Loss

Summary: the purpose of this study is to evaluate the enhanced signal processing features of the nucleus 6 sound processor on existing nucleus cochlear implant recipients currently using the nucleus 5 sound processor.


Eligibility criteria:
inclusion criteria: * greater than 12 years * unilateral cochlear implant recipient (ci24re, ci500, ci422) * minimum of 3 months experience with the n5 sound processor * prior documentation of sentence recognition testing in noise at a difficulty of +10 db snr or better * native english speaker * willingness to participate in and comply with all requirements of the protocol exclusion criteria: * unrealistic expectations * unwillingness to comply with investigational requirements of the protocol * additional handicaps that would prevent or restrict participation in the evaluations
treatment of immunoglobulin a (iga) nephropathy by angiotensin-converting enzyme (ace) inhibitor

Conditions: Glomerulonephritis

Summary: to evaluate the efficacy of the ace inhibitor ramipril in the treatment of early iga nephropathy.


Eligibility criteria:
inclusion criteria: * biopsy-confirmed iga nephropathy * proteinuria less than 0.5 g per day, normal blood pressure, and serum creatinine below 120 µmol/l exclusion criteria: * pregnant or nursing mother, or women of childbearing potential without an effective method of birth control * history of myocardial infarction, congestive heart failure, or any other medical indication that necessitate the use of ace inhibitor * evidence of clinically significant hepatic, gastrointestinal, autoimmune disease * history of malignancy, drug or alcohol abuse * participation in any previous trial on ace inhibitor * taking other investigational drugs within the past 30 days * known history of sensitivity / allergy to ace inhibitor the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
optic nerve sheath diameter, carotid duplex and transcranial duplex as a prognostic factor

Conditions: Neurologic Dysfunction

Summary: optic nerve sheath diameter (onsd) had been proved to be associated with increased intracranial pressure and can be used as one of the prognostic factors in cardiac arrest patients. it is simple, quick and can be measured repeatedly. carotid duplex and transcranial duplex(tcd) provide rapid, noninvasive, real-time measures of cerebrovascular function. it can be used to assess the vascular territory by measuring blood flow, and to evaluate factors include brain perfusion, plaque morphology, and patency of intracranial collaterals. hence, it could act as a crucial role in neuroprognosis in post-arrest patients. in this study, the investigator aimed to analyze the onsd diameters, onsd/external transverse diameter (etd) ratio, carotid duplex and transcaranial duplex parameters in different stages of post-cardiac arrest care, demographic characteristics and resuscitation information with the neurological outcome of post-cardiac arrest patients. the onsd diameter, and onsd/etd ratio were compared with age-, and sex-matched normal volunteers.

prediction of the neurological outcome in resuscitated post-cardiac arrest patients is important to tailor appropriate management plans. brain imaging, electrophysiological evaluations, biomarkers all take part in neuroprognosis in cardiac arrest patients, however, these modalities are more expensive or not suitable to repeat in a short time. optic nerve sheath diameter (onsd) had been proved to be associated with increased intracranial pressure2 and can be used as one of the prognostic factors in cardiac arrest patients. it is simple, quick and can be measured repeatedly. carotid duplex and transcranial duplex(tcd) provide rapid, noninvasive, real-time measures of cerebrovascular function. it can be used to assess the vascular territory by measuring blood flow, and to evaluate factors include brain perfusion, plaque morphology, and patency of intracranial collaterals. hence, it could act as a crucial role in neuroprognosis in post-arrest patients. in this study, the investigator aimed to analyze the onsd diameters, onsd/etd ratio, carotid duplex and transcaranial duplex parameters in different stages of post-cardiac arrest care, demographic characteristics and resuscitation information with the neurological outcome of post-cardiac arrest patients.

Eligibility criteria:
inclusion criteria: . non-traumatic cardiac arrest adult patients achieving return of spontaneous circulation after resuscitation exclusion criteria: * traumatic cardiac arrests * non-traumatic arrest patients without return of spontaneous circulation after resuscitation
efficacy of acupuncture for discogenic sciatica

Conditions: Sciatica

Summary: this trial is designed to evaluate the efficacy of acupuncture on pain relief for patients with discogenic sciatica compared with sham acupuncture.

background: sciatica is primarily caused by herniated discs with nerve-root compression. acupuncture may effectively relieve the pain of discogenic sciatica, but the evidence is limited. methods/design: sixty patients with discogenic sciatica will be recruited and randomized to receive acupuncture or sham-acupuncture at a 1:1 ratio. patients in both groups will receive treatment 3 times per week for 4 weeks. the following acupoints will be used: dachang shu (bl 25), shenshu (bl 23), weizhong (bl 40), and chengshan (bl 57).

Eligibility criteria:
inclusion criteria: 1. unilateral leg pain diagnosed as discogenic sciatica; 2. sciatica patients with an average leg pain vas of 40 mm or higher in the last 24 hours; 3. aged 18 to 75 years; 4. leg pains that correlate with ct or mri findings of lumbar disc herniation; 5. patients who agree to follow the trial protocol. exclusion criteria: 1. severe cases with central or giant or ruptured lumbar disc herniation, cauda equina syndrome, foot drop, or surgery requirements; 2. progressive neurological symptoms after 3 months of strict conservative treatment (e.g., nerve root adhesion, crossed straight-leg testing, or obvious muscle atrophy); 3. severe cardiovascular, liver, kidney, hematopoietic system diseases, autoimmune diseases, or poor nutritional status; 4. subjects with cognitive impairment; 5. pregnancy; 6. subjects who received acupuncture for sciatica within the past month.

Keywords: discogenic acupuncture therapy randomized controlled trial
exercise prehabilitation among older patients with hematological malignancies preparing for car-t cell immunotherapy

Conditions: Lymphoma; Leukemia; Myeloma

Summary: the purpose of the study is to evaluate an exercise program for individuals preparing for chimeric antigen receptor (car) t-cell immunotherapy for hematological malignancies.


Eligibility criteria:
inclusion criteria: * age ≥65 years * lymphoma, leukemia, or myeloma with commercial fda-approved car-t delivery planned for ≥4 weeks following enrollment * eastern cooperative oncology group (ecog) performance status 0-2 * able to read and speak english fluently * capable of providing informed consent * for optional, tele-supervised aerobic training procedure involving stationary bicycle delivery, participants must live within a 2-hour drive of moffitt cancer center as determined via google maps. exclusion criteria: * regular engagement in resistance training (2x/week targeting all major muscle groups) * screen failure for exercise safety based on physical activity readiness questionnaire (par-q) and patient-reported measurement information system (promis) screening questions * underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease (new york heart association functional class iii or iv). * recent fracture or acute musculoskeletal injury that precludes ability to participate in rt using body weight * numeric pain rating scale of ≥ 7 out of 10 * myopathic or rheumatologic disease that impacts physical function * cognitive, visual, or auditory limitations that preclude safe engagement in remotely-supervised resistance training sessions or independent aerobic exercise (as determined by patients' treating oncologists and specified in clinic notes outlining disease history).
nmda enhancer for the treatment of mild alzheimer's disease

Conditions: Alzheimer Disease

Summary: nmda neurotransmission plays an important role in learning and memory. nmda receptors (nmdar) were found to decrease in the frontal lobe and hippocampus of alzheimer's disease (ad). this study is a randomized, double-blind, placebo controlled drug trial for testing the efficacy of nmdar-enhancer. all subjects will be allocated randomly to 4 groups: (1) daoi-a group; (2) daoi-b group; (3) daoi-c group; (4) placebo group. the study period is 24 weeks. the investigators hypothesize that daoi may yield better efficacy than placebo for cognitive function in patients with ad.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of alzheimer's disease * mmse between 10-26 * cdr 1 exclusion criteria: * hachinski ischemic score \> 4 * substance abuse/dependence * parkinson disease, epilepsy, dementia with psychotic features * major depressive disorder * major physical illnesses * severe visual or hearing impairment
mobilization for post partum low back pain

Conditions: Low Back Pain, Mechanical

Summary: the study was conducted to the following purposes 1. to investigate the effect of lumbar mobilization on muscle activity in postpartum mechanical low back pain. 2. to investigate the effect of lumbar mobilization on pain intensity in postpartum mechanical low back pain patients. 3. to investigate the effect lumbar mobilization on functional disability in postpartum mechanical low back pain patients. 4. to compare between the effects of lumbar mobilization, tactile stimulation (placebo treatment) and traditional treatment in postpartum mechanical low back pain patients.

all participants divided randomly into three groups, group a (study group) received pa lumbar mobilization plus traditional treatment which consisted of ultrasonic and infra-red. group b (placebo group) received placebo mobilization plus traditional treatment. group c (control group) received traditional treatment only

Eligibility criteria:
inclusion criteria: females with lbp lasting more than 3 months since their delivery * their age range 25-35 years old with body mass index (bmi) less than 30kg/m2 exclusion criteria: * medical conditions that don't allow the subject to lie prone comfortably as, cardiovascular disease, uncontrolled hypertension, abdominal hernia, severe respiratory diseases, as well as problems in the back e.g. previous low back surgery, spinal malignancy. in addition to known rheumatic joint disease, and upper or lower motor neuron lesion that affects lower limbs

Keywords: mechanical lbp mobilization postpartum
predictive value of baseline ctq-sss scores for progression to carpal tunnel release surgery: a cohort study

Conditions: Carpal Tunnel Syndrome

Summary: this study aims to determine the predictive value of baseline ctq-sss scores for progression to carpal tunnel release (ctr) surgery in patients with carpal tunnel syndrome (cts). it will be a prospective cohort study involving at least 200 patients with cts who are undergoing nonsurgical management. participants will complete the ctq-sss and other functional measures at baseline, 3 months, 6 months, and 12 months, and the primary outcome will be progression to ctr surgery. logistic regression models will be used to assess the predictive value of baseline ctq-sss scores for progression to ctr surgery, adjusting for potential confounding factors such as age, sex, and baseline symptom severity. the results of this study can help clinicians identify patients who may benefit from early surgical intervention.


Eligibility criteria:
inclusion criteria: * patients with symptoms consistent with carpal tunnel syndrome, such as numbness, tingling, or pain in the hand or wrist. * patients with a positive nerve conduction study confirming carpal tunnel syndrome, or patients with clinical symptoms and signs consistent with carpal tunnel syndrome if a nerve conduction study is not available or inconclusive. * patients who have not undergone hand or wrist surgery within the past 6 months. * patients who are 18 years of age or older. * patients who are willing and able to provide informed consent and comply with study requirements. exclusion criteria: * patients with a history of hand or wrist surgery within the past 6 months. * patients with severe hand or wrist pain that would prevent completion of the outcome measures or interfere with their ability to participate in the study. * patients with severe cognitive impairment or language barrier that would prevent understanding of the study instructions or interfere with their ability to participate in the study. * patients with other neurologic or musculoskeletal disorders that could affect hand function or interfere with test completion. * pregnant or breastfeeding women. * patients who have participated in another clinical trial within the past 30 days.
the nordic deltacon trial for displaced proximal humeral fractures in elderly

Conditions: Proximal Humeral Fracture

Summary: the nordic deltacon trial is a prospective, single-blinded, randomized, controlled, multi-center and multi-national trial comparing reverse prosthesis and non-operative treatment in displaced proximal humerus fractures, in the elderly patients aged 65 to 85 years with displaced ota/ao group b2 or c2 fractures (according to the new 2018 revision: ao/ota (orthopaedic trauma association) group 11-b1.1, 11-b1.2 and 11-c1.1, 11-c3.1. )

single-blinded, multi-center, multi-national (finland, sweden, denmark, norway) primary outcome in this study is quickdash (the short form of disabilities of the arm, shoulder and hand) score measured at two years. secondary outcomes are quickdash at/after one, two (short term) and five years (medium term), general visual analog scale (vas) for pain, oxford shoulder score (oss), constant-score (cs), number of re-operations and complications. quality of life is assessed with 15-d. cost-effectiveness analysis will be performed after completion of the trial. in addition to 2 years main outcome (short term) follow-up will continue to 5 years (medium term) and 10 years (long term). the power calculation is based on 2 years.

Eligibility criteria:
inclusion criteria: low energy ao/ota group 11-b1.1, 11-b1.2 and 11-c1.1, 11-c3.1. both b and c type includes subgroups: displaced \[2\], impacted \[3\] or non impacted \[4\] from the universal modifiers list. exclusion criteria: radiographic mal-inclination less than; varus 30°or valgus 45° less than 50% contact between head fragment and meta-/diaphysis head split fractures with more than 10% of the articular surface in the main head fragment. head split fractures (group 11-c3.2 and 11-c3.3) with more than 10% of the articular surface in the main head fragment. dislocation or fracture-dislocation of the gleno-humeral joint pathological fracture general * refuse to participate * age under 65 years of age, or over 85 years of age * serious poly-trauma or additional surgery * non-independent, drug/alcohol abuse or institutionalized (low co-operation) * contra-indications for surgery * does not understand written and spoken guidance in local languages * previous fracture with symptomatic sequelae in either shoulder * patients living outside the hospital's catchment area

Keywords: displaced non-operative treatment reversed total shoulder prosthesis
phase ii randomized study on locally advanced nsclc escalated dose on individual basis treatment with radiochemotherapy

Conditions: Non Small Cell Lung Cancer; Locally Advanced Disease

Summary: the purpose of this study is to examine the valu of individually dose escalated radiotherapy compared with a standard dose of radiotherapy combined with standard concomitant chemotherapy for patients with locally advanced non small cell lung cancer (stage iii) with good performance status.

this is an open label, multicentre phase ii trial of individually escalated radiotherapy up to 84 gy due to normal tissue dose constraints combined with standard concurrent chemotherapy (cisplatin-vinorelbine) compared to standard dose radiotherapy (68 gy) combined with the same chemotherapy. there are restrictions due to lung function, performance status and pre-treatment weight loss. the main endpoint is progression free survival and additional endpoints are local control, overall survival, toxicity quality of life and relapse pattern.

Eligibility criteria:
inclusion criteria: * histological or cytological diagnosis of nsclc stage iiia-b. * nonresectable or medically inoperable patients. * no prior chemo- or radiotherapy for nsclc. * ps 0-1. * fev1 \> 1 l or \> 40% and co diffusion capacity \> 40%. * patient compliance and geographic proximity that allow adequate follow-up. * adequate bone marrow reserve: wbcc \>3.0, platelets \>100, haemoglobin \> 100. * written informed concent. * effective use of contraception. exclusion criteria: * excessive weight loss within 6 months (\> 10%). * supraclavicular nodes. * apical tumors-pancoast. * t4 tumors with separate manifestations in different lobes. * evidence of active serious infections. * inadequate liver function. * inadequate kidney function. * pregnancy. * breast feeding. * serious concomitant systemic disorder. * second primary malignancy the last 5 years.

Keywords: radiotherapy dose escalation normal tissue constraints locally advanced disease good performance status
implantation of porous titanium prosthesis in laryngeal surgery

Conditions: Vocal Cord Paralysis

Summary: this study evaluates a medialization implant to treat vocal cord paralysis, to permit it to adjust the quality of the voice under local or general anesthesia. the aim is to restore phonation using a porous titanium prosthesis in laryngeal surgery.


Eligibility criteria:
inclusion criteria: * males or females greater than 18 years old exclusion criteria: * age less than 18 years * pregnant women * local carcinoma excluding radiotherapeutic or surgical control * bad general condition * contraindication to general anesthesia * non-controlled diabetes

Keywords: porous titanium implants thyroplasty vocal cord paralysis male or female more than 18 years old