Kornimate/medical-research-clean huggingface dataset:
high salt intake unrelated to obesity in diabetes

Conditions: Diabetes Mellitus, Type 1; Food Habits

Summary: people around the world are consuming much more sodium than is physiologically necessary. a number of studies suggest that dietary sodium intake is related to weight gain. the aim of our study was to evaluate in a population of children and adolescents with type 1 diabetes mellitus, possible correlations between the urinary sodium excretion (una24h), indirect marker of sodium intake, and both duration of diabetes and bmi z-score(body mass index). moreover, we also evaluated the correlation between una24h and duration of diabetes according with the presence/absence of overweight/obesity.

elevated sodium intake has been associated with hypertension, cardiovascular diseases and stroke, and decreasing sodium intake may reduce blood pressure and the risk of cardiovascular diseases (cvds), leading cause of death in the world. recent data on sodium intake show that populations around the world are consuming much more sodium than is physiologically necessary. studies in children have reported positive associations between sodium intake and adiposity. the aim of our study was to evaluate in a population of children and adolescents with type 1 diabetes mellitus, possible correlations between the urinary sodium excretion (una24h), indirect marker of sodium intake, and both duration of diabetes and bmi z-score. moreover we also evaluated the correlation between una24h and duration of diabetes according with the presence/absence of overweight/obesity.

Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus exclusion criteria: * patients with celiac disease, thyroid disease, other autoimmune diseases, concurrent illness, patients with diabetic nephropathy, other renal disease and in therapy with natriuretic drugs
effect of transcutaneous auricular electroacupuncture on sleep disturbances in patients with rheumatoid arthritis: a randomized double-blind clinical trial

Conditions: Transcutaneous Electric Nerve Stimulation; Rheumatoid Arthritis; Sleep Quality

Summary: the purpose of this clinical trial is to determine whether transcutaneous auricular vagus nerve stimulation (tavns) is suitable for improving sleep disorders in patients with rheumatoid arthritis (ra). it will also evaluate the safety of tavns. the main questions it aims to answer are: can tavns improve the sleep quality of ra patients? what medical issues might ra patients experience while receiving tavns treatment? researchers will compare tavns with a placebo (a similar substance that does not contain the actual treatment) to see if tavns is effective in improving sleep disorders in ra patients. participants will: receive tavns or sham stimulation daily for 4 weeks keep a daily sleep diary and visit the hospital once a week for check-ups and tests record their sleep quality and related symptoms this study aims to provide a new, safe, and effective non-drug therapy for sleep disorders related to ra.


Eligibility criteria:
inclusion criteria: 1. meets the 2010 acr/eular criteria for rheumatoid arthritis. 2. poor sleep quality (psqi score \> 7). 3. disease activity is moderate to low or in remission (das28 score ≤ 5.1). 4. no risk of sleep apnea (stop-bang questionnaire \< 3). 5. aged between 18 and 70. 6. the type and dosage of rheumatoid arthritis medication must be stable for at least 4 weeks. 7. signed informed consent. exclusion criteria: 1. people with acute infectious diseases, whether generalized or localized; 2. those with severe internal organ diseases (such as coronary heart disease, arrhythmia, malignant tumors, renal failure, etc.); 3. those working night shifts during the intervention period; 4. those with other rheumatic diseases such as systemic lupus erythematosus, fibromyalgia, and sjogren's syndrome; 5. those undergoing treatment with steroids, sleeping pills, antidepressants, or antipsychotics; 6. pregnant and breastfeeding women; 7. those who cannot tolerate transcutaneous auricular electrostimulation.
her-2 expression in pancreatic duct adenocarcinoma

Conditions: Pancreatic Adenocarcinoma

Summary: pancreatic duct adenocarcinoma is a highly aggressive carcinoma that is associated with a poor prognosis. detection of novel biological markers that are specifically over expressed in pancreatic duct adenocarcinoma and their subsequent targeting by anti cancer therapeutic modalities may improve patient's survival.

pancreatic duct adenocarcinoma (pdac) is a deadly neoplasm that showed current increase in its occurrence. there are many challenges in pdac; the tumor is frequently associated with perineural invasion and angioinvasion, these lead to early metastasis.another important challenge is that the tumor is associated with extensive fibrosis that prevents arrival of chemotherapeutic agents. most modern anti-cancer therapeutic modalities depend on the biologic signature of the tumor. human epidermal growth factor receptor-2 (her-2) is a cell surface protein that is associated with enhanced cellular proliferation. her-2 has been detected and successfully targeted in many human carcinomas as breast and gastric cancers. we aimed to evaluate the potential cancer-promoting effect of her-2 in pdac, in order to detect any possible benefits of its targeting by future therapeutic modalities.

Eligibility criteria:
inclusion criteria: 1. cases of pdac who underwent radical operations. 2. tissue blocks with sufficient material. 3. cases with available clinical data. exclusion criteria: 1. cases of pancreatic carcinoma other than pdac. 2. patients who received preoperative chemotherapy or radiotherapy. 3. patients with pdac who were diagnosed by tru-cut biopsies only and didn't undergo radical operations. 4. cases with insufficient/destructed material. 5. patients with inadequate clinical data.

Keywords: her-2 pancreatic duct adenocarcinoma immunohistochemistry
examination of textile solutions for reducing physiological stress

Conditions: Physiological Stress

Summary: using protective or combat garments under heavy heat stress conditions, during rest or exertion, may hinder the body's ability to effectively exchange heat with the environment and thereby can lead to heat injuries. the purpose of this research is to physiologically examine the new textile solutions that are planned to be integrated in the protective garments, combat garments and work uniforms in the army, by evaluating the physiological stress obtained during exertion under hot climatic conditions.

10 young, healthy civilian volunteers will participate in this study. after reading and signing an informed consent form, all subjects will undergo medical examination which includes ecg, anthropometric measurements and vo2max test. afterwards, the subjects will perform 6 acclimatization days carried out by the standard protocol of heat tolerance test (htt). after acclimatization, the subjects will undergo 4 experiment days under heavy heat stress in a climatic chamber, dressed in each experiment day with one out of 4 clothing combinations (nbc protective garment \[charcoal base\], combat garment and 2 different types of work uniforms). physiological stress will be evaluated from rectal temperature and heart rate measurements.

Eligibility criteria:
inclusion criteria: * aged 18-30 years. * healthy civilian volunteers. * without known medical illness or medication use. exclusion criteria: * the existence or suspicion of existing cardiac or respiratory disease. * hypertension. * diabetes. * psychiatric condition. * any muscles or skeledon condition. * any hormonal disease or any other chronic illness that may inhibit participation in the experiment. * infectious disease 3 days prior to the experiment.

Keywords: stress when dressed protective garment work clothes
comparison of two mechanical ventilation modes on oxygenisation

Conditions: Bariatric Surgery Candidate; Mechanical Ventilation; Hypoxia; Tissue Damage

Summary: comparison the effect of two different mechanical ventilation modes on tissue oxygenization.

aim of the study is to evaluate and compare the effects of two different mechanical ventilation modes as volume controlled mechanical ventilation (vcv) and pressure controlled mechanical ventilation (pcv) on non invasive tissue oxygenization levels of patients who scheduled for bariatric surgery.

Eligibility criteria:
inclusion criteria: patients with body mass index 35 - 50 kg/m2 patients classified as american society of anesthesiologist (asa) 1-2-3 classification patients elected for bariatric surgery exclusion criteria: patients who wants to reject of study participation patients who has any surgical complication during the surgery period patients with decompensated cardiac failure patients with moderate or severe obstructive/restrictive lung disease patients with reynaud disease patients with buerger phenomena patients whıo has intraoperative airway pressure more than 45 cmh2o patients who had previous thoracic surgery patients with negative modified allen test

Keywords: bariatric surgery, tissue oxygenization, ventilation
peg-asp+gemoxd vs. peg-asp+chop as first-line chemotherapy to treatment nk/t-cell lymphoma with early stage

Conditions: Lymphoma

Summary: extranodal natural killer/t-cell lymphoma (enktl) is an aggressive subtype of non-hodgkin's lymphoma and shows extremely poor survival. several retrospective studies and singe-arm prospective phase 2 studies have shown that pegaspargase combined gemox or chop regimen achieved a promising efficacy in treatment of enktl. however, there is no prospective study to compare the efficacy of these two regimens. this prospective pilot study to compare the efficacy and safety of the p-gemoxd chemotherapy regimen with those of the p-chop regimen for stage ie to iie enktl.

treatment pa-gemoxd dosages were as follows: days 1 and 5, 30-min intravenous infusion of 800 mg/m2 gemcitabine; day 1, 2-h intravenous infusion of 85 mg/m2 oxaliplatin; day 1, deep intramuscular injection of 2000 u/m2 peg-asp at four different sites; d1-5, intravenous infusion of 15mg dexamethasone. the regimen was repeated every 3 weeks for four cycles followed by involved-field radiotherapy after got cr, pr or sd. three-dimensional conformal radiotherapy was done by linear accelerator at 2.0 grays (gy) per daily fraction with 5-6 weeks. the involved- field radiation (ifrt) dose was 50-56 gy.

Eligibility criteria:
inclusion criteria: 1. pathologically confirmed, previously untreated enktl with stage i/ii (for stage i, the patients should have one of the following risk factors: ebv-dna \> upper limit of normal, lesions beyond nasal, fever, ldh elevation); 2. age range from 18 to 70 years; 3. eastern cooperative oncology group (ecog) performance status of 0-2; 4. at least one measurable lesion; 5. adequate haematologic function (haemoglobin \> 8.0 g/l, absolute neutrophil count \> 1500/ml, platelets \> 75,000/l), 6. adequate hepatic function (total serum bilirubin ≤ 1.5 times the upper limit of normal, alanine aminotransferase and aspartate aminotransferase ≤ 2.5 times the upper limit of normal), 7. hepatitis b virus carriers should have normal hbv-dna copies and should use antiviral drugs. for patients with elevated hbv-dna, should use antiviral drugs until the hbv-dna decrease to \< the upper limit of normal. 8. adequate renal function (serum creatinine ≤ 1.5 mg/dl, creatinine clearance ≥ 50 ml/min); 9. normal coagulation function and electrocardiogram results. 10. prior chemotherapy and radiotherapy should have been completed \>4 weeks earlier, 11. willingness to provide written informed consent. exclusion criteria: 1. mismatch the inclusion criteria 2. systematic central nervous system involvement, previous or concomitant malignancies and any coexisting medical problems that could cause poor compliance with the study protocol. 3. primary lesion not from the upper respiratory
are cesarean section and appendectomy in pregnancy and puerperium interrelated?

Conditions: Appendicitis Acute; Cesarean Wound Disruption With Postnatal Complication

Summary: it is not known whether appendectomy for acute appendicitis (aa) increases the cesarean section (cs) rate and whether cs increases the likelihood of aa and appendectomy in the early puerperium. in this study, delivery type and delivery outcomes and appendectomy during pregnancy and puerperium were analyzed.

this cross-sectional retrospective study was performed on 11513 women, delivered during 2015-2020. inclusion criteria were patients submitted to appendectomy for aa during pregnancy and the first six weeks after delivery. evaluating parameters were age, parity, gestational week at birth, delivery type, and babies' birth weight.

Eligibility criteria:
inclusion criteria: women aged 18-45 years submitted to appendectomy for acute appendicitis during pregnancy or within the first six weeks after delivery were included. - exclusion criteria: cases with missing data were excluded. -
developing methods to investigate additional opportunities of hpv vaccination by using first-void urine samples

Conditions: Human Papilloma Virus Infection

Summary: the main objective of this study is to develop protocols using fv urine that investigate in vitro whether infectious virions can be neutralized by hpv vaccination.

in total 50 women will be included in this trial whereof 25 fully vaccinated with a prophylactic hpv vaccine and 25 not vaccinated with a prophylactic hpv vaccine. these women will be asked to collect a first-void urine sample with the colli-peetm device (novosanis). hereafter, a blood sample of 5-10 cc will be collected. hpv dna positive women who gave their consent to be contacted with the results, will later be contacted again and asked to provide additional fv urine samples every day during 2 weeks. for this, urine collection devices (colli-peetm, novosanis) will be provided by postal mail. the collected urine samples (and blood sample as control for hpv antibodies) will be used for the development of protocols within this project.

Eligibility criteria:
inclusion criteria: * female * 18-25 years of age * sexually active or has been sexually active in the past * cases (n=25): fully vaccinated women, i.e. receiving all necessary doses of the hpv vaccine (according to the kce recommendations) able to prove their vaccination (brand and schedule) with an official document. * control group (n=25): women self-reported to be not previously vaccinated with a single dose of any prophylactic hpv vaccine available. * willing to give informed consent to the cev research team. * giving consent to the research team (cev) to contact his/her general practioner and/or gynaecologist to access details of the participants hpv vaccination (schedule) and results of cervical smears/cytology, hpv tests, colposcopy, and biopsy (included in icf) exclusion criteria: * women participating in another clinical study at the same time of this study. * women that underwent hysterectomy or were treated for cervical (pre)cancer lesions within the previous six months prior to study enrolment.

Keywords: first-void urine self-sampling vaccination infectious virions neutralizing antibodies hpv
reducing edema following refractive surgery

Conditions: Edema

Summary: determine if edema plays a role in refractive surgery

prospective, comparative study

Eligibility criteria:
inclusion criteria: 1. patients who underwent bilateral refractive surgery for myopic correction. 2. age 18-60. 3. evidence of an epithelial defect. 4. uncorrected visual acuity at study visit better than 20/40 5. patients able to understand the requirements of the study and willing to follow study instructions, to provide written informed consent to participate, and who agree to comply with all study requirements, including the required study follow-up visits. exclusion criteria: 1. any other anterior segment abnormality other than that associated with refractive surgery. 2. any abnormalities associated with the eye lids. 3. prior laser treatment of the retina. 4. any ophthalmic surgery performed within three (3) months prior to study excluding refractive surgery. 5. diagnosis of glaucoma. 6. active diabetic retinopathy. 7. clinically significant inflammation or infection within six (6) months prior to study. 8. uncontrolled systemic disease (e.g., diabetes, hypertension, etc.) in the opinion of the investigator. 9. participation in any study involving an investigational drug within the past 30 calendar days, or ongoing participation in a study with an investigational device. 10. intolerance or hypersensitivity to topical anesthetics 11. a medical condition, serious intercurrent illness, or extenuating circumstance that would significantly decrease study compliance, including all prescribed follow-up. 12. any condition that, in the opinion of the investigator, would jeopardize the safety of the patient.

Keywords: refractive surgery
activated autologous t cells against glioma cancer stem cell antigens for patients with recurrent glioblastoma

Conditions: Recurrent Glioblastoma

Summary: the purpose of this study is to examine the use of activated t cells (atcs) to assess the safety and tolerability of autologous activated t cells, as measured by the number of grade 3 or higher toxicities, the number of serious adverse events, and treatment-related toxicities, according to national cancer institute common toxicity criteria for adverse events (nci ctcae) version 5, to find the maximum tolerated dose. the secondary objectives include evaluating the rate of overall survival, rate of progression-free survival, health-related quality of life parameters, overall response rate, immune response, and tumor stem cell antigen expression.


Eligibility criteria:
inclusion criteria: * recurrent glioblastoma * hla-a1 and hla-a2 positive * complete resection of tumor exclusion criteria: * clinically significant pulmonary, cardiac or other systemic disease * presence of an acute infection requiring active treatment with antibiotics/antivirals; prophylactic administration is allowed. * known human immunodeficiency virus positivity or acquired immunodeficiency syndrome related illness or other serious medical condition. * known history of hepatitis b or hepatitis c * allergy to dimethyl sulfoxide (dmso) * allergy to gentamicin

Keywords: glioma brain tumor glioblastoma neurosurgery surgical resection complete resection of tumor extent of resection maximal safe resection neuropathology astrocytoma ependymoma
safety of kae609 in adults with uncomplicated plasmodium falciparum malaria.

Conditions: Malaria

Summary: kae609 will be evaluated primarily for hepatic safety of single and multiple doses in sequential cohorts with increasing doses.this study aims to determine the maximum safe dose of the investigational drug kae609 in malaria patients.


Eligibility criteria:
key inclusion criteria: 1. male and female patients ≥ 18 years with a body weight ≥ 45 kg. 2. microscopic confirmation of acute uncomplicated p. falciparum using by giemsa-stained thick film. 3. p. falciparum parasitaemia of 500 to 50 000 parasites/µl. 4. axillary temperature ≥ 37.5ºc or oral/tympanic/rectal temperature ≥ 38.0ºc; or history of fever during the previous 24 hours. 5. written informed consent must be obtained before any study assessment is performed. if the patient is unable to write, then a witnessed consent according to local ethical standards is permitted. key exclusion criteria: 1. mixed plasmodium infections. 2. signs and symptoms of severe malaria according to world health organization (who) 2016 criteria (who 2016). 3. known liver abnormalities, liver cirrhosis (compensated or decompensated), known active or history of hepatitis b or c (testing not required), known gallbladder or bile duct disease, acute or chronic pancreatitis. 4. clinical or laboratory evidence of any of the following: 5. ast/alt \> 1.5 x the upper limit of normal range (uln), regardless of the level of total bilirubin 6. ast/alt \> 1.0 and ≤ 1.5 x uln and total bilirubin is \> uln 7. total bilirubin \> 2 x uln, regardless of the level of ast/alt 8. history of photodermatitis/increased sensitivity to sun. 9. pregnant or nursing (lactating) women. 10. known disturbances of electrolyte balance, e.g. hypokalemia, hypocalcemia or hypomagnesemia. 11. moderate to severe anemia (hemoglobin level \<8 g/dl). other protocol-defined inclusion/exclusion criteria may apply

Keywords: uncomplicated plasmodium falciparum malaria.
sensory integration versus bobath on hand function in hemiplegia

Conditions: Children With Hemiplegia

Summary: hand skills do not develop in isolation; it is the result of neurologic development, physiologic maturation and adaptation, and functional development of learned patterns of motion and motor learning hand skills in hcp are very complex and sensitive as it considered the main issue in playing and achieving milestones, so identification of this problem and its solution is very essential and play a miserable rule in adaptive response which is a basis of child's occupation. so, the current study is conducting to investigate the difference between sensory motor integration approach and bobath technique on hand function as manual dexterity, fine motor precision and fine motor integration on children with hemiplegic cerebral palsy

sensory integration therapy is the therapeutic mechanism of pediatrics through sensory augmentation which involves the child in enriched playful tasks, promoting a meaningful motor response. the sensory integration theories assume that an affected sensory reception would result in a defect or delay in the development of milestones among children with motor disorders. the bobath approach provided a new reference aimed to normalize tone and facilitate volitional and automatic movement which tailors based on the patient's individual problems and situational context to manage problems with movement against gravity and postural control participants will be assigned randomly into two groups of equal number (study group 1 and study group 2 )26 child in each group * study group "1" will receive regular physical therapy in addition to sensory motor integration for 45 minutes/time ,3 days per week for 3 months treatment program included two parts: tactile sensation and proprioception stimulation programs. each of them accounted half of the session * study group"2" will receive regular physical therapy in addition to bobath therapy for 45 minutes/time 3 days per week for 3 months in the form of: 1. preparation phase 2. intervention program (movement facilitation \&functional training) base line assessment and after three months re assessment will be taken for both groups using surface electromyography and bruininks-oseretsky test of motor proficiency 2nd edition

Eligibility criteria:
inclusion criteria: 1. age ranges from 6 to 12 years. 2. both genders. 3. diagnosis of hemiplegia. 4. level ii-iii on manual ability classification system (macs) 5. spasticity grade 2 to 3 on modified ashworth scale (mas) 6. level ii-iii on gross motor classification system (gmcs) exclusion criteria: 1. significant mental or psychological problems. 2. significant visual/auditory problem. 3. botox injection and/or surgery of the affected upper limb in the past 12 months. 4. surgical procedures of the affected upper limb. 5. fixed deformities in the affected upper limb. 6. comorbid physical diseases such as myopathy, neuropathy, and other central and peripheral nervous system disorders. -

Keywords: sensory integration hand function