Kornimate/medical-research-clean huggingface dataset:
texture features and pdl1 in ct-pet 18 fdg

Conditions: Non Small Cell Lung Cancer

Summary: search correlation between texture features in ct-pet 18 fdg and overexpression of pdl1 in non-small cell lung carcinomas during the inital staging. the hypothesis is that overexpression of pdl1is correlated with at least one texture feature among those selected. 84 ct-pet 18 fdg at the initial staging of a non small cell lung carcinoma (adenocarcinoma or squamous cell carcinoma), whose the biopsed site was the primitive site or the drainage lymphadenopathy, without previous treatment, were recruited and analyzed by a software allowing to estimate texture features.


Eligibility criteria:
inclusion criteria: * adult patient ; * first ct-pet 18 fdg realized for the inital staging ; * absence of previous treatment for a thoracic neoplasm ; * biopsy realized on the primitive site or local drainage lymphadenopathy ; * primitive site viewable with morphological imagery ; * availability of evaluation of pdl1's overexpression ; exclusion criteria - refusal to participate in this research

Keywords: correlation between overexpression of pdl1 texture features ct-pet 18 fdg non small cell lung carcinoma
tolerance of anti-cancer therapy in the elderly

Conditions: Frailty; Chemotherapeutic Toxicity

Summary: this is a multicentre observational study evaluating frailty and tolerance of chemotherapy in the elderly.

this is a multicentre observational study evaluating frailty and tolerance of chemotherapy in the elderly. the number of people with cancer over the age of 65 years is increasing and more older patients are being treated with chemotherapy. previous research has shown that patients living with frailty are more likely to experience significant toxicity from chemotherapy. a scoring system exists, the carg (cancer aging research group) score), which using sociodemographics, tumour/treatment variables, laboratory test results (haemoglobin and creatinine clearance), geriatric assessment variables (function, co-morbidity, cognition, psychological state, social activity/support and nutritional status) predicts the likelihood of patients in this population developing a grade 3-5 toxicity. the carg score ranges from 0 (lowest toxicity risk) to 19 (highest toxicity risk). this scoring system was developed and validated in the usa (united states of america). it was not however found to be predictive of toxicity in australia. to date it has not been evaluated, nor is used in routine practice in oncology in the uk (united kingdom). this study is looking at markers of frailty in patients \>65years. the investigators seek to predict those who are at a higher risk of side effects from chemotherapy. the investigators are looking to validate the carg score in a uk nhs (national health service) population and show feasibility of using this in routine practice. the investigators are also evaluating if other scoring systems which are routinely used to assess frailty (but have never been assessed for predicting toxicity) are useful in predicting toxicity. secondary objectives include describing frailty in this population, exploring patients' perceptions of risk associated with chemotherapy and demonstrating the added value of risk prediction tools compared to clinicians estimates of toxicity risk.

Eligibility criteria:
inclusion criteria: * age \>65years * about to start first line chemotherapy for a solid tumour based malignancy * chemotherapy given for any intent eg. adjuvant or palliative * estimated survival of \>3months * able to comprehend and complete questionnaire. exclusion criteria: * medical or psychiatric condition impairing ability to consent * participant is enrolled in another clinical trial * prior chemotherapy for any indication * receiving concurrent radiotherapy (rt) or immunotherapy (it) * unable to provide informed consent

Keywords: frailty chemotherapy tolerance
a study to investigate the efficacy and safety of bemdaneprocel in adults who have parkinson's disease

Conditions: Parkinsons Disease (PD)

Summary: study brt-da01-301 is a phase 3 multicenter, randomized, sham surgery-controlled, double-blind study to assess efficacy and safety of bemdaneprocel in approximately 102 adults with parkinson's disease (pd).

the brt-da01-301 study is a phase 3, multicenter, randomized, sham surgery-controlled, double-blind study involving approximately 102 participants with parkinson's disease (pd). participants will be randomized in a 2:1 ratio to either receive bemdaneprocel or undergo sham surgery. the study includes an immunosuppression regimen and placebo equivalents to maintain blinding. the primary objective is to evaluate the efficacy of bemdaneprocel on motor symptoms in participants with pd. the secondary objective is to evaluate the effects of bemdaneprocel on motor function, quality of life, non-motor symptoms of pd, disease severity, and use of pd medications or therapies compared with participants who undergo sham surgery. participants will be followed for at least 18 months in the double-blind period and up to five years if they receive bemdaneprocel.

Eligibility criteria:
inclusion criteria: 1. individual of any sex ≥45 to ≤75 years of age at informed consent 2. diagnosis of clinically established pd 3. ≥4 and \<12 years from time of pd diagnosis at informed consent 4. must demonstrate responsiveness to levodopa therapy 5. receiving medical therapy for the treatment of pd symptoms 6. ≥2.5 hours of daily off-time exclusion criteria: 1. pd presenting with recurrent falls 2. diagnosis of primary mitochondrial disorder, epilepsy, stroke, multiple sclerosis, or clinical features suggestive of a neurodegenerative disease other than pd, including multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, or lewy body dementia 3. any current or relevant previous history of serious, severe, or unstable physical, neurological, or psychiatric illness that may interfere with study participation, participant's safety, or assessment of endpoints per investigator's judgment 4. history of gene therapy or cell therapy 5. prior surgical or radiation therapy to the brain, including deep brain stimulation (dbs) and lesion therapy, or prior history of intradural spinal cord surgery 6. contraindication to surgery, general anesthesia, cell therapy, immunosuppression, or other required drugs 7. current or previously active malignant disease within the past 5 years 8. chronic immunosuppressive therapy 9. receipt of another investigational therapy 10. pregnancy or breastfeeding

Keywords: expdite-2 cell therapy cellular therapy dopaminergic neuronal cell therapy parkinsons disease
trospium chloride xr in obese female patients with overactive bladder

Conditions: Obesity; Overactive Bladder; Incontinence

Summary: this study evaluated the effectiveness of trospium chloride extended release (xr) in obese female patients with overactive bladder (oab). patients received either placebo and trospium chloride xr or placebo only. the study assessed the change from baseline in urinary frequency, urgency, and incontinence for trospium chloride xr versus a placebo-pill. the study was 14 weeks in duration.


Eligibility criteria:
inclusion criteria: * oab syndrome with urgency, urinary frequency and urgency urinary incontinence * non-smoker (refrained from any tobacco usage, including smokeless tobacco, nicotine patches, etc., for 6 months prior to the screening visit). * obese exclusion criteria: * chronic kidney failure * abdominal bypass surgery for obesity * moderate or severe memory impairment * uncontrolled narrow angle glaucoma * uncontrolled systemic disease * concurrent dementia drugs: aricept (donepezil), namenda (memantine), cognex (tacrine), exelon (rivastigmine), razadyne (galantamine), or similar drugs for dementia
effectiveness of wound drains for the prevention of surgical site infection

Conditions: Surgical Site Infection; Gynecologic Cancer; Wound Drain

Summary: the aim of the present randomized trial is to assess the efficacy of wound drains in terms of reducing the rates of surgical site infection in obese patients with gynecological cancer.

many prophylactic methods have been suggested for the treatment of surgical wound infections, including the prolonged administration of antibiotics as well as the use of subcutaneous tissue drainage, the use of which has been shown to be particularly effective in overweight patients. while its importance seems to be moderate in obese patients as well as those that suffer from malignant disease, to date, it remains unknown if wound drains may help reduce the rates of surgical site infection in obese patients that suffer from cancer. in the field of gynecological oncology data are limited to anachronistic studies whose methodological value is limited; hence, guidelines are primarily based in data of high risk of bias as to date, the value of subcutaneous tissue drainage in obese women undergoing surgery for gynecological cancer has not been documented in a large randomized study. considering the significant impact of surgical site infection on the interval to adjuvant therapy (as patients with infectious diseases cannot receive chemotherapy or radiotherapy), it becomes evident that every effort has to be made in order to help reduce the rates of ssi to help maintain acceptable intervals that will ensure appropriate care of patients.

Eligibility criteria:
inclusion criteria: this prospective randomized study will include obese (bmi\> 35) patients who will undergo primary surgery for ovarian or endometrial cancer exclusion criteria: immunodeficient patients (systemic disease including hiv infection, systemic lupus erythematosus etc) patients with hematologic diseases
treatment of m.graves with radioactive iodine: follow-up study

Conditions: Hyperthyroidism

Summary: hypothesis: what is the natural course after treatment with radioactive iodine in patients with hyperthyroidism? what are the determinants for the development of acute hypo- or hyperthyroidism after treatment with radioactive iodine without antithyroid drugs?


Eligibility criteria:
inclusion criteria: * patients wth hyperthyroidism who are eligible for treatment with radioactive iodine * age \> 18 years exclusion criteria: * severe ophthalmopathy * pregnancy or wish to pregnancy on short term * breastfeeding * patients already treated with radioactive iodine * known cardiovascular diseases or other severe comorbidity

Keywords: hyperthyroidism radioactive iodine antithyroid drugs hyperthyroidism, treatment with radioactive iodine without antithyroid drugs
hyperbaric oxygen treatment (hbot) during methadone tapering

Conditions: Opioid Use Disorder

Summary: the aims of this study are to 1) explore the efficacy of hyperbaric oxygen therapy (hbot) applied at two different pressures compared to sham treatment in relieving signs and symptoms (both physical and psychological) of opioid withdrawal in human subjects associated with methadone dose reductions; and 2): explore whether hbot can increase the odds of successful methadone dose reduction in patients who are interested in tapering their opioid dose. the investigators aim to explore, through qualitative methods, individual's experiences with treatment for opioid use disorder (oud).

the investigators will conduct a prospective, randomized, sham treatment-controlled trial to examine the efficacy of hbot for improving signs and symptoms of opioid withdrawal in methadone-maintained oud patients as they undergo two planned methadone dose reductions spaced two weeks apart. a participant sample size of 24 was chosen based on power analysis guided by the investigators' earlier study that indicate that clinically meaningful results can be found with a minimum of 8 per group related to variables of highest interest i.e., pain and withdrawal symptoms. additionally to this trial, participants will be asked to partake in a semi-structured interview in which they will be asked to discuss (1) beginning treatment, (2) life in recovery, and (3) hbot \& further treatment. edited 11/23/24: an additional study arm was added to better address the question about the level of hbot needed for effects. the new participant sample size of 36 was chosen based on power analysis guided by our earlier study that indicate that clinically meaningful results can be found with a minimum of 8 per group related to variables of highest interest i.e., pain and withdrawal symptoms. participants will be randomized into one of three trial arms: (active arm of n = 12 in hbot 100% oxygen and 2.0 ata, partial active arm of n = 12 in hbot 100% oxygen and 1.3 ata, and sham arm of n = 12 in hbot 21% oxygen and 1.3 ata). all groups will be receiving standard of care for addiction withdrawal symptoms, as managed and provided by their clinic physician and neither the full or sub-therapeutic hbot dose are expected to affect their ongoing treatment.

Eligibility criteria:
inclusion criteria: * enrollment in a supervised opioid treatment program at the spokane regional health district * age greater than 18 years * ability to read, speak, and write english * ability to provide written informed consent. exclusion criteria: * pregnancy * any other medical or psychiatric condition that the pi, co-pi (physician of record) or the spokane hyperbaric center medical director determine might compromise safe study participation in the hbot clinic (including but not limited to active psychosis, history of frequent psychiatric hospitalizations, severe anxiety with claustrophobia, aggression) * upper respiratory infection * emphysema * air cysts in the lung * history of thoracic or ear surgery * taking the medication antabuse for alcohol addiction * high fever.
exercise adherence and cognitive decline

Conditions: Cognitive Decline

Summary: the purpose of this study is to conduct a small-scale test of a goals-based program to help people to exercise more and learn what people like or don't like about the procedures. this program is being designed for individuals aged 45-65 from the black community. low levels of physical activity are related to health problems such as heart disease, diabetes, and cognitive decline. people of color are more negatively impacted by these conditions and have also historically been underrepresented by research seeking to increase physical activity. the investigators have developed this goals-based exercise promotion program with the help of a black-led community-based organization (the gyedi project) and a community advisory board made up of stakeholders in the black community, and now the investigators are conducting a trial of its feasibility and acceptability.


Eligibility criteria:
inclusion criteria: * \<3 incorrect responses on the pfeiffer mental status questionnaire * ages 45-65. * consent to be randomized to condition. * planning to remain in the denver metro area for the next two months * identify as black or african american exclusion criteria: * currently physically active (i.e., \>90 min/week of moderate pa or \>40 min/week of vigorous pa consistently for the past 6 months). * on antipsychotic medications or currently under treatment for any serious psychiatric disorder, including alzheimer's or dementia * answers "yes" to 1 or more of the 7 questions of the par-q+ * blood pressure at baseline or before exercise is greater than 140/90 * blood pressure \>210/90 mmhg (for men) or \>190/90 mmhg (for women) immediately after exercise * inability to walk 3 blocks without chest pain, shortness of breath, or light headedness. * inability to climb 2 flights of stairs without chest pain, shortness of breath, or light headedness.

Keywords: goals exercise intensity goal difficulty cognitive decline
vitamin d supplementation prevents elderly pneumonia

Conditions: Bacterial Pneumonia

Summary: pneumonia is the fourth leading cause of death and frequently occurs in institutionalized elderly people in japan. recently, several clinical and experimental studies have reported the importance of vitamin d in the regulation of immune functions and its deficiency is associated with susceptibility to some infections. in the present study, the investigators hypothesize that deficiency of serum vitamin d is associated with development of pneumonia, and supplementation of vitamin d may lower the incidence of pneumonia and prolong survival in institutionalized elderly subjects.


Eligibility criteria:
inclusion criteria: * subjects are more than 65 years old and were resident in the facility for at least 6 months. * subjects have no conditions known to interfere with vitamin d metabolism. exclusion criteria: * subjects are excluded if they have: * renal failure * hepatic failure * hyper- or hypo-parathyroidism * hiv infection, or malignant diseases * subjects are also excluded if they are taking corticosteroid, thiazide diuretics, or supplementary vitamins.

Keywords: vitamin deficiency
evaluation of rapid t2-weighted and dwi mr sequences reconstructed by deep learning for prostate imaging

Conditions: Prostate Cancer

Summary: mr prostate exam is essential for the diagnosis, workup and follow-up of prostate cancer. it allows to detect subclinical prostate cancer following an increase in the level of psa. the investigators can score the lesion according to the pirads classification and obtain an estimate of lesion malignancy. to perform this classification, t2 and dwi sequences are essential. detection and characterization of malignant lesion is important to address appropriate patient care pathway. the purpose of this project is to evaluate novel deep learning (dl) t2-weighted tse (t2dl) and diffusion (dwidl) sequences for prostate mr exam and investigate its impact on diagnostic, examination time, image quality, and pi-rads classification compared to standard t2-weighted tse (t2s) and standard diffusion (dwis) sequences.


Eligibility criteria:
inclusion criteria: * age ≥ 18 ans * healthy subject without history of hepatic disease * patient addressed for an prostate mri * ability to give consent exclusion criteria: * claustrophobia, * major obesity (\>140 kg), * patient under guardianship or curators * age \< 18 years, * women, * history of prostatectomy or irradiation of the prostate * any contraindication to mri exam

Keywords: t2 fse t2 dlr diffusion dwi diffusion dlr deep learning prostate cancer pirads
pegfilgrastim given same day as or day after carboplatin and docetaxel in advanced metastatic non-small cell lung cancer (nsclc)

Conditions: Lung Cancer; Non-Small Cell Lung Cancer

Summary: the purpose of this research study is to evaluate the safety and effectiveness of neulasta® (pegfilgrastim) in reducing infection when given on the same day versus one day after the completion of chemotherapy (docetaxel and carboplatin) in patients with advanced or metastatic non-small cell lung cancer (nsclc). this study is considered to be "investigational" because previous studies with neulasta® used next day dosing and not same day dosing.


Eligibility criteria:
eligibility criteria: - age 18 years or older - diagnosis of advanced or metastatic non-small cell lung cancer (nsclc) - have not received any prior chemotherapy - have not received radiation therapy or undergone major surgery within the past 2 weeks

Keywords: metastatic cancer neulasta® pegfilgrastim
prevalence and risk evaluation of diabetic complications of the foot in a large canadian population

Conditions: Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 1; Foot Deformities; Onychauxis; Neuropathy, Diabetic; Hyperkeratosis; Onychomycosis; Foot Ulcer, Diabetic

Summary: the study aims to assess foot complications among patients with diabetes in canada, using patient data collected during diabetes foot assessments performed by the lmc chiropody team between february 27, 2018 and april 17, 2019.

among patients with diabetes, one of the major causes of increased morbidity and mortality include lower-extremity complications. patients who have peripheral neuropathy and peripheral arterial disease are at risk of developing foot ulcers and infection, which can lead to lower-extremity amputations. adults with diabetes in canada are 20 times more likely to be hospitalized for a nontraumatic lower limb amputation than adults without diabetes. thus, the prevention, education and early treatment of diabetes foot complications are an important component of caring for patients living with diabetes. in addition to neuropathy and peripheral arterial disease, risk factors for developing foot ulcers include increased levels of glycated hemoglobin, onychomycosis, microvascular complications, previous foot ulcer or amputation, structural deformity, and limited joint mobility. to the best of our knowledge, the prevalence of foot complications, such as onychomycosis, and the association of diabetes foot complications with glycemic control and other diabetes risk factors, has not been assessed before in a large sample of canadian patients. to better understand foot complications among patients with diabetes in canada, the investigators will retrospectively examine patient data collected during diabetes foot assessments performed by the lmc chiropody team. the lmc chiropody team is part of lmc diabetes \& endocrinology, which is one of the largest endocrine practice groups globally.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * diagnosis of type 1 or type 2 diabetes * under the care of an endocrinologist at lmc * diabetes foot assessment was performed by the lmc chiropody team * informed consent to use patient medical record data for research purposes was provided exclusion criteria: * prior diabetes foot assessment by an lmc chiropodist

Keywords: diabetes observational study diabetic foot complications