Kornimate/medical-research-clean huggingface dataset:
inspiring nutritious selections and positive intentions regarding eating and exercise (inspire)

Conditions: Obesity; Eating Disorder

Summary: the aims of the current study are: 1) to pilot a manualized intervention (inspire - inspiring nutritious selections and positive intentions regarding eating and exercise) to determine feasibility and acceptability, and 2) to evaluate the preliminary effectiveness of inspire on physical and psychological variables.

the purpose of the current study is to implement an evidence-based prevention program to promote positive health behaviors among young adult women. it will be one of the first to intentionally execute a prevention program targeting well-established risk factors for both obesity and eating disorders in this high-risk population. intervention content focuses on promoting body size diversity and emphasizing positive health and behavior change in order to reduce stigmatization and remain sensitive to weight-related issues. the manual was developed by integrating two successful existing prevention programs and expanding on previous prevention efforts. specifically, the diversity of beauty ideals were highlighted to enhance relevance among ethnic minority women, and distress tolerance and emotion regulation skills training were included to target the maladaptive coping mechanisms young adults use to manage the stress associated with transitioning to college.

Eligibility criteria:
inclusion criteria: * currently enrolled in postsecondary education at virginia commonwealth university exclusion criteria: * bmi ≥ 30 kg/m2 * meet criteria for eating disorder threshold risk * pregnancy
effect of different iloprost doses on symptoms in systemic sclerosis

Conditions: Systemic Sclerosis

Summary: this study compared the efficacy of different dosages of long-term iloprost treatment on raynaud's phenomenon, ulcer healing, skin thickening, and progression of internal organ sclerosis in systemic sclerosis (ssc). methods. 50 ssc patients were 1:1 randomised either for maximally tolerated dose up to 2 ng/kg body weight \[bw\] per minute or low dose (0.5 ng/kg bw per minute) intravenous iloprost administration, for six hours daily over 21 days. the effect on rp, ulcer healing, skin thickness, oesophagus function, lung involvement as assessed by lung function parameters fvc and dlco, and side effects were measured. conclusions. the efficacy of prolonged administration of iloprost is also achieved with low dose iloprost by long term treatment. the effects suggest a disease-modifying capability of iloprost, but further studies are needed to proof this hypothesis.

50 ssc patients (23 patients with limited ssc; 15 patients with diffuse ssc, and 12 patients with overlap syndromes fulfilling the acr criteria for systemic sclerosis) and suffering from severe raynaud's phenomenon were included into the study after written informed consent to participate in this study. severe raynaud's phenomenon was defined by a high burden of disease, by trophic skin changes, or the presence of digital ulcers. patients suffering from ssc related rp and/or digital ulceration were randomized 1 : 1 to one of the following groups that received either high or low dose infusions of iloprost for 21 consecutive days given once or twice a year. high dose patients (n=25) started on 0.5ng per kg bw and min over 6 hours a day. depending on the tolerability the dosages were increased in increments gradually every two days for 0.5 ng/kg x min. the maximum dose administered was 2.0ng/kg bw and min. low dose patients (n=25) were permanently treated with 0.5ng/kg bw over 6 hours per day for 21 consecutive days.

Eligibility criteria:
inclusion criteria: * patients with secondary raynaud's phenomenon suffering from severe raynaud-'s phenomenon with trophical changes or from digital ulcers with written informed consent. patients had to be stable for their systemic disease and were on stable medication concerning immunosuppression or vasoactive therapies for three months. exclusion criteria: * current smokers, patients with a history of gastric ulcers in the last three months, a cardiac ejection fraction below 25%, patients with severe organ involvement or other uncontrolled diseases such as instable angina pectoris, severe anaemia, coagulopathies, azothaemia, cerebral stroke in the last 6 months or malignant diseases were excluded from the study. the last iloprost therapy had to be finished at least 6 months ago. participation in other studies during the last 4 weeks was also not allowed. for fertile women, a negative pregnancy test was required.

Keywords: iloprost systemic sclerosis digital ulcers observational study randomized
effects of inspiratory muscle training in patients with pulmonary hypertension

Conditions: Hypertension, Pulmonary

Summary: this study aims to determine the possible effects of inspiratory muscle training on cardiovascular, respiratory, physical and psychosocial functions in patients with ph.

pulmonary hypertension (ph) is a hemodynamic finding related to increase in pulmonary artery pressure. because ph disease is a progressive, rare disease, it is important for this disease group to prolong the life span and to increase the quality of life and functional capacity. ph patients have been shown to have weakness in peripheral and respiratory muscles. patients will be randomly assigned to the inspiratory muscle training and control group. inspiratory muscle training will be initiated in accordance with the patient at a range of 40-60%. i̇nspiratory muscle training will be given based on the assessments by the physiotherapist. patients with ph who come to the routine outpatient clinic and volunteer will be included in the study. the first session will be the evaluation session and the 8-week inspiratory muscle training will be given, the other group will be the control group only. dyspnoea, diaphragm thickness, pulmonary function, respiratory and peripheral muscle strength, blood pressure, arterial stiffness, physical activity, anxiety, depression and quality of life assessments will be repeated before and after the treatment.

Eligibility criteria:
inclusion criteria: * diagnosis of pulmonary hypertension * according to the new york heart association functional class ii - iii * cases receiving stable medication for 3 months exclusion criteria: * conditions which can limit the assessments * severe ischemic heart disease * acute cor pulmonale

Keywords: pulmonary hypertension inspiratory muscle training muscle weakness
effectiveness and cost-effectiveness of surgical treatment of humeral shaft fractures. randomized controlled trial

Conditions: Fracture

Summary: humeral shaft fractures represent 1-3% of all fractures and 20% of the humeral fractures. these fractures have historically been treated mainly conservatively with good results. recent development in fracture treatment and findings that certain fracture types are more prone to non-union and bracing-related functional problems of adjacent joints are somewhat common have caused increasing interest in treating these fractures surgically. return to activities is also considered to be quicker among surgically treated patients. the purpose of this study is to evaluate effectiveness and cost-effectiveness of surgical treatment of humeral shaft fractures. patients with an unilateral humeral shaft fracture who are willing to participate in the study after informed consent are randomly assigned to two different treatment methods: 1. surgical treatment with an open reduction and internal fixation with a 4,5mm locking plate. 2. conservative treatment with functional bracing the randomization is done using blocked randomization (block sizes are not known by the enrolling or assigning physician) and stratification is done according to fracture type (ao-ota type a vs. type b/c) and radial nerve status (total/subtotal motor palsy vs. no palsy). standard follow-up visits at 6 weeks, 3, 6 and 12 months are arranged. later follow-up visits are arranged at 2, 5 and 10 years for the study purpose. patients fill evaluation forms and clinical and radiological assessments are made. the physiotherapist doing objective functional measurements is blinded to treatment method. both study groups receive physiotherapy after the initial treatment.


Eligibility criteria:
inclusion criteria: * over 18 years old patient who agrees to the consent to participation in this study * unilateral dislocated humeral shaft fracture (dislocation over thickness of the bone cortex, fracture below the level of insertion of pectoralis major muscle and 5 cm above the olecranon fossa) * randomization can be done within 10 days and operation within 14 days after the initial trauma * patient is willing to participate all follow-up visits exclusion criteria: * bilateral humeral shaft fracture * a significant concomitant trauma of the same upper extremity that warrants operative treatment (fracture, tendon injury, soft tissue trauma) * other fracture or abdominal/thoracal trauma that warrants operative treatment * open fracture * pathological fracture * multi-trauma patient * vascular injury * plexus injury * previous trauma in the same upper extremity that causes functional deficit * trauma or condition that warrants use of walking aid (crutches, wheelchair etc) * disease that affects significantly general condition of the patient * significantly impaired ability to co-operate for any reason (substance abuse, mental disorder, dementia) * unwilling to accept both treatment methods

Keywords: humerus humeral shaft diaphysis fracture rct
testing an arts-based program to reduce nurse stigma towards perinatal substance use

Conditions: Nurse's Role; Stigma, Social; Implicit Bias

Summary: the goal of this pilot clinical trial is to evaluate the feasibility and limited effectiveness of a digital, arts-based educational intervention addressing nurse stigma towards perinatal substance use. the main questions it aims to answer are: * what is the the feasibility of delivering the training through an asynchronous, web-based platform? * what is the limited effectiveness of the program on nurse stigma towards perinatal substance use? participants will access and complete the training, including completion of a perinatal substance use stigma scale at baseline, immediately post, and 1-2 months month later. participants will also be invited to participate in an interview. researchers will compare the intervention and control groups to see if the training reduces nurse stigma towards perinatal substance use.


Eligibility criteria:
inclusion criteria: * age 18 years or older * licensed as a registered nurse * works at least part time * works on a labor, postpartum, nursery, neonatal intensive care, or pediatric unit in one of the participating hospitals exclusion criteria: * works as per diem or agency nurse * not employed by a participating hospital * not a perinatal/pediatric nurse
transient elastography and variceal bleeding

Conditions: Bleeding

Summary: transient elastography is a new non-invasive rapid and reproducible method, allowing evaluating liver fibrosis by measurement of liver stiffness. the aim of our study is to evaluate if the liver stiffness can predict the recurrence of upper variceal bleeding in cirrhotic patients hospitalized for variceal rupture.


Eligibility criteria:
inclusion criteria: * informed consent form signed * social security affiliation * variceal bleeding with hematemesis or melena within 24 hours of inclusion * age \> 18 years * scheduled to undergo endoscopy within 24 hours of hospital admission exclusion criteria: * hepatocarcinoma * upper gastro intestinal bleeding for other causes than variceal bleeding * concomitant disease with a life expectancy of less than 45 days * rebleeding within 24 hours after first endoscopy * technical failure of transient elastography

Keywords: variceal bleeding transient elastography
male breast cancer predisposition factor

Conditions: Breast Cancer

Summary: this is a non-interventional, prospective, single-center study designed to collect and describe environmental and psychosocial data from patients with a history of male breast cancer (mbc) referenced in the iuct-o regional database. the study will be conducted on a population of 110 to 150 patients.


Eligibility criteria:
inclusion criteria: 1. male patient with a personal history of breast cancer 2. age ≥ 18 years 3. patient who has had an oncogenetic consultation at iuct-o and is registered in the iuct-o oncogenetic database 4. patient for whom no pathogenic variant has been detected on the hboc panel (hboc-) 5. patient with no objection to participation in the trial (for deceased patients: trusted support person with no objection to participation). exclusion criteria: 1. patient who has forfeited his/her freedom by administrative or legal award or who is under legal protection (curatorship and guardianship, protection of justice).

Keywords: breast cancer predisposition factor
the value of addition of human menopausal gonadotropin drug following oocytes retrieval in ivf cycles

Conditions: Infertility

Summary: the aim of this study is to test the hypothesis that addition of daily small dose of human menopausal gonadotropin (hmg) drug following oocytes retrieval could improve the fertility outcome in women undergoing in-vitro fertilization

the study will be conducted in the ivf unit of cairo university. females undergoing icsi cycles in the age between 20 and 40 years will be allocated to one of 2 groups. long agonist protocol will be used. allocation to either one of 2 groups will be done on the day of oocytes retrieval. the first group will take (in addition to the routine care) daily human menopausal gonadotropin drug injection for 2 weeks. the second group will receive the routine care.

Eligibility criteria:
inclusion criteria: * females undergoing intra-cytoplasmic sperm injection (icsi) cycles * age between 20 and 40 years exclusion criteria: * females who have high response (estradiol at time of ovulation trigger is \> 5000 pg/ml or more than 15 oocytes are retrieved)
neoadjuvant nab-paclitaxel and s-1 in resectable pancreatic cancer

Conditions: Pancreatic Neoplasms

Summary: there were limited data for nab-paclitaxel and s-1 in pancreatic cancer. to explore the efficacy and safety of neoadjuvant nab-paclitaxel combined with s-1 in patients with resectable pancreatic cancer (stage ii and partial stage iii defined according to the national comprehensive cancer network definitions ), we designed this study. this study was a single-arm single center prospective phase ii clinical study. a total of 72 subjects who meet the criteria will receive neoadjuvant chemotherapy of nab-paclitaxel and s-1 prior to pancreatectomy. response was reported according to the response evaluation criteria in solid tumors guidelines (recist, version 1.1) .the primary endpoint is objective response rate. the secondary endpoints include r0/r1 resection rate, disease free survival, overall survival and safety.


Eligibility criteria:
inclusion criteria: 1. signed informed-consent form; 2. treatment-naive pdac with histological or cytological diagnosis; 3. resectable pancreatic cancer stage ii and partial stage iii defined according to the national comprehensive cancer network definitions; 4. age≥18 years old and ≤70 years old; 5. eastern cooperative oncology group (ecog) performance status of 0 or 1; 6. bmi≥18.5 and nrs2002score\<3; 7. expected survival over 3 months; 8. spared organ function satisfying the following laboratory data:leucocyte≥3.0x109/l,neutrophils≥1.5x109/l, hemoglobin≥ 9g/dl, platelets ≥100x109/l, total bilirubin ≤ 1.5 uln; ast and alt≤ 2.5 uln; serum creatinine≤1.5uln; pt and inr≤ 2.5 uln; exclusion criteria: 1. severe impaired organ functions; 2. patients who had surgeries, chemotherapy or other treatments before inclusion; 3. pregnant women or lactating women; 4. ineligible by the discretion of the investigator.
mindob: a 12-month computerized mindfulness-based intervention for obese individuals

Conditions: Obesity; Binge-Eating Disorder

Summary: the purpose of this study is to evaluate the efficacy of a daily 12-month computerized mindfulness-based intervention in obese patients diagnosed with binge eating disorder (bed) on: impulsive eating, motivation toward exercise, and weight loss.


Eligibility criteria:
inclusion criteria: * adult aged between 18 and 65 years * obese (bmi \>= 30) * recruited from the nutrition pole of ambroise paré hospital * diagnosed with binge-eating disorder (bed) according to dsm5 criteria * informed consent provided during inclusion interview exclusion criteria: * already participating in a clinical trial * bariatric surgery patients (except for gastric band removed at least 3 years before) * planned bariatric surgery * central obese (genetic) * pregnant women * no internet access at home * difficulties to understand french language * patients under social protection * cognitive dysfunctions in understanding simple guidelines provided by the paramedical staff (e.g., diet or exercise guidelines) * auditory disorders not allowing to hear audio files * blurred vision not allowing to use internet

Keywords: motivation impulsive eating mindfulness self-help physical activity weight-loss
value of mri in congenital heart disease

Conditions: Congenital Heart Disease

Summary: congenital heart disease (chd) is the most prevalent congenital anomaly and a major cause of infant morbidity and mortality. it encompasses various cardiac chamber anomalies. chd diagnosis relied on clinical information from auscultation and heart sounds, with x-rays providing indirect information. since the 1970s, echocardiography has become the primary diagnostic tool due to its direct, safe, and portable nature, capable of defining anatomy and estimating hemodynamics. however, echocardiography has limitations, while ct provides valuable anatomical details, it lacks hemodynamic information and involves ionizing radiation. mri, on the other hand, excels in both anatomical and functional analysis, offering detailed hemodynamic evaluations of blood flow through valves, great vessels, and septal defects.

congenital heart disease (chd) is the most prevalent congenital anomaly and a major cause of infant morbidity and mortality. it encompasses various cardiac chamber anomalies such as septal defects, valvular lesions, and outflow tract anomalies. advances in diagnostic tools, medical management, and surgical techniques have significantly improved survival rates, with over 90% of children with complex chd living into adulthood. as of 2012, the prevalence of chd was estimated at 3000 per million, and in the u.s., the number of adults with complex chd increased from 110,000 in 1968 to 270,000 in 2010. historically, chd diagnosis relied on clinical information from auscultation and heart sounds, with x-rays providing indirect information. since the 1970s, echocardiography has become the primary diagnostic tool due to its direct, safe, and portable nature, capable of defining anatomy and estimating hemodynamics. however, echocardiography has limitations, including a restricted window of visualization. previously, ct and mri faced challenges due to cardiac motion artifacts, but advancements in rapid imaging and high-resolution technology have improved their diagnostic capabilities. while ct provides valuable anatomical details, it lacks hemodynamic information and involves ionizing radiation. mri, on the other hand, excels in both anatomical and functional analysis, offering detailed hemodynamic evaluations of blood flow through valves, great vessels, and septal defects.

Eligibility criteria:
inclusion criteria: * infants and children who diagnosed or suspected congenital heart diseases * infants and children who can tolerate sedation or general anesthesia exclusion criteria: * patients with contraindications to mri as pacemaker or defibrillator * patients unable to tolerate sedation or anesthesia

Keywords: congenital heart disease mri
frequency of interrupting sitting and cognitive function

Conditions: Sedentary Behaviors; Breaking Prolonged Sitting with Physical Activity

Summary: rationale: sedentary behavior (sb) has been associated with impaired cognitive function in elderly, and negatively impacts glucose metabolism. interrupting sitting with physical activity (pa) bouts may exert beneficial effects on cognitive function via an improved glucose metabolism. nevertheless, the impact of breaking up prolonged sitting with various frequencies of pa bouts remains unexplored in young sedentary adults. moreover, we hypothesize that the pattern of the breaks modifies the effects. thus, randomized controlled trials (rcts) are highly needed to investigate the effects of interrupting sitting with different frequencies of pa on cognitive function and glucose metabolism. we now hypothesize that interrupting sitting with different frequencies of walking breaks differentially affects cognitive function and glucose metabolism. objective: the aim is to investigate the effects of breaking up sitting with different frequencies of pa bouts on cognitive function and glucose metabolism in young sedentary adults. study design: a randomised, controlled cross-over study will be performed, consisting of four interventions in a counterbalanced order: uninterrupted prolonged sitting, short breaks, moderate breaks, and long breaks. intervention: participants will complete four conditions in a randomized, counterbalanced order: sitting (uninterrupted prolonged sitting without any interruptions), short breaks (walk 1 minute every 10 minutes), moderate breaks (walk 3 minutes every 30 minutes), and long breaks (walk 27 minutes during the intervention). each condition lasts 4.5 hours.


Eligibility criteria:
inclusion criteria: * men and women aged 18-35 years; * bmi between 18.5-24.9 kg/m2; * sb, i.e. sitting for an average of at least 9 hours per day; * physically inactive, i.e. engaging in exercise for less than 2 to 3 times per week; * stable body weight (weight gain or loss \< 3 kg in the past three months); * willingness to engage in four 6-hour laboratory visits; * no difficult cannulation. exclusion criteria: * not sedentary, i.e. sitting for less than an average of 9 hours per day; * physically active, i.e. engaging in exercise for more than 3 times a week; * abuse of drugs; * use medication to treat bp, lipid, or glucose metabolism; * pregnant females.

Keywords: sedentary behavior sitting interruptions cognition glucose metabolism
evaluation of corneal endothelial cell density in subjects who have had a fluocinolone acetonide implant

Conditions: Inflammation; Uveitis

Summary: investigate the impact of the fluocinolone acetonide (fa) intravitreal implants

investigate the impact of the fluocinolone acetonide (fa) intravitreal implants on corneal endothelial cell density.

Eligibility criteria:
inclusion criteria: * had the fa intravitreal implant (0.59 or 2.1 mg) in only one eye for at least one(1) year * able and willing to follow instructions * able and willing to provide informed consent exclusion criteria: * is monocular * has current or relevant medical history that would interfere with their participation in this study, based on the judgment of the investigator * had bilateral fa intravitreal implants * has a history of any severe/serious ocular pathology or medical condition that could result in the subject's inability to complete the study
bioequivalency study of levetiracetam 750 mg tablets under fed conditions

Conditions: Seizures

Summary: the objective of this study was to prove the bioequivalence of levetiracetam 750 mg tablets under fed conditions


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. treatment with known enzyme altering drugs. history of allergic or adverse response to levetiracetam or any comparable or similar product.