Kornimate/medical-research-clean huggingface dataset:
effectiveness of modified-free gingival graft for treatment of localized gingival recession defects

Conditions: Gingival Recession, Localized

Summary: the aim of the present study is to evaluate, whether use of the modified free gingival graft (mod-fgg) technique improves treatment outcomes after surgical root coverage at mandibular incisors with gingival recession defects.

gingival recession defects (grd), defined as displacement of the gingival margin apical to the cemento-enamel junction, are frequent clinical findings in the general population. the major indications for root coverage procedures are improved esthetics, reduction of root hypersensitivity and the increase of the dimensions of keratinized tissue in order to facilitate infection control and prevent further progression of gingival recession defects. numerous surgical techniques for root coverage have been suggested, with different degrees of success as assessed by the proportion of complete root coverage. the scientific evidence has revealed that mandibular incisors were associated with the least favourable outcomes when compared to other teeth. the lower success rate and lower predictability of root coverage procedures at lower incisors, teeth with the highest frequency of grds, may be related to the unfavorable anatomic conditions including marginal frenum attachment, high muscle pull and a shallow vestibule. these features are frequently encountered in the anterior area of the mandible, while they are rare in the maxillary anterior region. the so-called "free gingival graft" (fgg) was shown to be the most effective procedure for gingival augmentation at sites with minimal amount of keratinized tissue. great variability in terms of proportion of root coverage (range: 11% to 87%; mean: 63%) has been reported when applying this technique, however. one of the challenges may be the inadequate blood supply to the portion of the fgg placed on the exposed root surface. a modified version of the fgg technique (mod-fgg) has been proposed, aiming to improve the vascularity of the recipient site over the denuded root surface. however, there is to date no scientific evidence whether the mod-fgg provides better clinical results than the conventional fgg. the hypothesis of the study is that the mod-fgg will improve predictability and treatment outcomes for root coverage at mandibular incisors.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * periodontally and systemically healthy * full-mouth plaque score and full-mouth bleeding score ≤ 20% (measured at four sites per tooth) * thin phenotype * probing pocket depth (ppd) ≤3 mm * absence of excessive tooth mobility * absence of cervical composite restorations or non-carious cervical lesions * shallow vestibule exclusion criteria: * pregnancy * smoking * alcoholism * para-functional habits * poor oral hygiene * excessive crowding or misalignment of teeth
improving sleep and reducing external stimuli with the maya

Conditions: Critical Illness

Summary: lack of sleep is a large problem for many patients in hospitals. common causes are nuisances by light and sound. especially with critically ill patients in the intensive care unit (icu), medium care unit (mcu) and cardiac care unit (ccu), who are are monitored intensively, a lack of sleep often occurs. patients with a lack of sleep more offer suffer from delirium, are more often anxious and stressed, and have a longer length of stay in the hospital. also, patients' lack of sleep enhances nurses workloads during nightshifts. because of this, there is a strong need for innovative devices which aim to limit the light and sound nuisances and thereby enhance patients' quality of sleep in the icu, mc and ccu. the maya is a special "cover" which can be placed over the head of the bed. as a result patients are able to limit light and sound nuisances and enhance their privacy. with this pilot-study we aim to determine: * the feasibility and experiences of patients and healthcare professionals with the maya. * to determine the effect size of dependent variables which can be used in future studies.


Eligibility criteria:
inclusion criteria: * adult icu, mc or ccu patients with 5 to 7 expected number of admission days * patients with an expected richmond agitation sedation scale (rass) of \>-3 and \< +3 * patients who speak dutch (because of the qualitative evaluation of the maya) exclusion criteria: * patients with severe brain damage * patients with a severe psychiatric disorder
efficacy and safety of eribulin in the treatment of advanced breast cancer

Conditions: Breast Cancer

Summary: chemotherapy is an important means to prolong the survival time of advanced breast cancer. as a new type of microtubule inhibitor, eribulin has a unique mechanism of action. compared with single drug chemotherapy, it can improve the overall survival time of 2.5 months, increase the clinical benefit rate by 5 times, and the tolerance of eribulin is good. therefore, the guidelines at home and abroad recommend eribulin for the rescue of advanced breast cancer. however, up to now, there is no large sample data on the efficacy of eribulin combined with anti her2 targeted therapy in her2 + metastatic breast cancer, and the efficacy of combined immunotherapy in triple negative metastatic breast cancer. moreover, as a newly marketed chemotherapy drug in china, the efficacy and safety data of eribulin in chinese population are relatively lacking. therefore, we plan to include different types and line numbers of advanced breast cancer patients based on the chinese population through real-world research, and receive the treatment regimen containing eribulin respectively. in hr + / her2-mbc, we use eribulin monotherapy; in her2 + mbc, we use eribulin + anti her2 targeted therapy; in tnbc, we use eribulin + immunotherapy / chemotherapy, the efficacy and safety of eribulin were evaluated.


Eligibility criteria:
inclusion criteria: 1. adult female patients (aged 18-80 years, including 18 and 80 years) with metastatic breast cancer confirmed by pathology or imaging are not suitable for surgical resection or radiotherapy for the purpose of cure; 2. the starting time of eribulin treatment was between january 2021 and december 2021; 3. they received no more than 2-line chemotherapy in the past; 4. in hr + / her2-mbc, patients were treated with eribulin monotherapy; in her2 + mbc, patients were treated with eribulin + anti her2 targeted therapy; in tnbc, patients were treated with eribulin + immunotherapy / chemotherapy; in patients with her2 + mbc, patients were treated with eribulin + immunotherapy /chemotherapy; exclusion criteria: 1. patients without pathological diagnosis; 2. patients with central nervous system metastasis; 3. she has received more than two chemotherapy regimens for metastatic breast cancer; 4. participating in any intervention drug clinical trials. 5. those who have been known to have allergic history to the components of this regimen; 6. the patient, the patient, or the person with serious harm to the safety of the study. 7. any other situation in which the researcher considers that the patient is not suitable for the study may interfere with the concomitant diseases or conditions involved in the study, or there are any serious medical barriers that may affect the safety of the subjects (e.g., uncontrollable heart disease, hypertension, active or uncontrollable infection, active hepatitis b virus infection)

Keywords: breast cancer eribulin real-world study
effects of sympathy and touch on anxiety of patients undergoing fiberoptic bronchoscopy

Conditions: Anxiety

Summary: the purpose of this study is to evaluate the effect of verbal expression of sympathy and touch on anxiety of patients undergoing fiberoptic bronchoscopy


Eligibility criteria:
inclusion criteria: * adult patients undergoing diagnostic fiberoptic bronchoscopy * hospitalized patients exclusion criteria: * patients who have undergone fiberoptic bronchoscopy * not hospitalized patients * cognitive impairment * refusal to enroll

Keywords: bronchoscopy anxiety touch sympathy
tearlab refractive surgery dry eye study

Conditions: Dry Eye Syndromes

Summary: the primary objective of this study is to determine how pre \& post-operative tear osmolarity levels relate to rates of dry eye symptoms related to refractive surgery and if differences exist in patients who are pre-treated with ocular lubricants vs. those treated only post-operatively.

dry eye disease is a common and major source of disability, whether occurring as a primary disorder or as a component of other diseases and its onset may be triggered or modified by exposure to systemic drugs, contact lens wear, ocular surgery and adverse environmental and work conditions. the development of a reliable, highly sensitive and specific test for the clinical diagnosis of dry eye is a major unmet clinical need, particularly to differentiate it from common conditions such as ocular allergy which exhibit similar presenting symptoms. tear hyper-osmolarity is central to the dry eye disease process and the measurement of tear osmolarity could serve not only as a highly accurate diagnostic test but also as a measure of disease severity and a means to monitor treatment efficacy. recently, there have been reports in the literature regarding dry eye disease; both early and chronic following refractive surgery, with many cases potentially being previously inadvertently undiagnosed dry eye disease.

Eligibility criteria:
inclusion criteria: * male or female, twenty-one years of age or older. * confirmed diagnosis of refractive error receiving lasik surgery. * patient motivation and willingness to cooperate with the investigator and ability to return for all visits during the study. exclusion criteria: * compromised cognitive ability that may be expected to interfere with study compliance. * clinically significant eyelid deformity or eyelid movement disorder that is caused by conditions such as notch deformity, incomplete lid closure, entropion, ectropion, hordeola or chalazia. * previous ocular disease leaving sequelae or requiring current topical eye therapy other than for ded, including, but not limited to: active corneal or conjunctival infection of the eye and ocular surface scarring. * active ocular allergy * patients requiring punctual occlusion prior to surgery * patients requiring cyclosporine ophthalmic emulsion prior to surgery * standard exclusion criteria for refractive surgery used by each surgeon. * known hypersensitivity to any of the agents used in testing * ophthalmologic drop use within 2 hours of any visit

Keywords: dry eye disease osmolarity refractive surgery lasik tearlab
knowledge attitudes beliefs and practices regarding hiv among teenagers in french guiana

Conditions: HIV

Summary: french guiana is the french territory where the prevalence of hiv is highest. in order to determine the knowledge attitudes, beliefs, and practices among the target group of teenagers attending the public school system a survey was conducted in 2011. schools and classrooms were randomly selected, and a structured questionnaire was administered. descriptive statistics were obtained and multivariate logistic regression was used to determine predictors of main outcomes such as age at first sex. the results will be used to guide prevention of hiv and sexually transmitted infections though the school system.


Eligibility criteria:
inclusion criteria: * attending the public school system of french guiana exclusion criteria: * refusal to participate
use of nava in intubated preterm

Conditions: Infant, Premature; Respiration, Artificial

Summary: the present protocol will demonstrate the feasibility and efficacy of a newly developed mode of mechanical ventilation, neurally adjusted ventilatory assist, commonly known as nava. during nava, the timing and magnitude of pressure delivered are controlled by the infants' diaphragm electrical activity (eadi), a validated measurement of neural respiratory drive. recent clinical trials in adults and term infants have shown that nava is more synchronous than conventional pressure support ventilation, and that nava delivers lower mean airway pressures to achieve the same ventilation and respiratory muscle unloading. nava has recently been approved for use in neonates by health canada and the fda in the united states, and is commercially available on the servoi ventilator (maquet critical care, solna, sweden). the present protocol is designed as a "case study" where the researchers responsible would like to evaluate the feasibility and efficacy of ventilating a premature baby on nava with the servoi for 12 hours.


Eligibility criteria:
inclusion criteria: * preterm newborn (\>1 day postnatal age, gestational age \>23 weeks, birth weight \<1250g), intubated and mechanically ventilated, and breathing spontaneously, as defined by the ability to trigger the ventilator. the infant should be breathing on conventional ventilation (simv, assist control, or pressure support) with the following ventilator parameters: assist control/pressure support \< 22 cm h2o, peep 4-6 cm h2o fi02\<.30 exclusion criteria: * pneumothorax, degenerative neuromuscular disease, bleeding disorders, cardiovascular instability, cyanotic congenital cardiovascular disease, phrenic nerve damage/diaphragm paralysis, esophageal perforation, use of high frequency oscillatory or jet ventilation, contraindication to changing ng tube, or if infant is deemed "too unstable" by the clinical team. the use of narcotics is an exclusion criteria.

Keywords: nava preterm case study
safety and efficacy of botox® (botulinum toxin type a) in korea

Conditions: Hyperhidrosis; Muscle Spasticity; Glabellar Lines

Summary: this post marketing surveillance study in korea will evaluate the safety and efficacy of botox (botulinum toxin type a) in patients who receive treatment according to standard of care for primary axillary hyperhidrosis, focal spasticity or moderate to severe glabellar lines in clinical practice.


Eligibility criteria:
inclusion criteria: * patients treated with botox® (botulinum toxin type a) as prescribed according to standard of care in clinical practice for primary axillary hyperhidrosis, focal spasticity or moderate to severe glabellar lines. exclusion criteria: * none.
physical exercise in normobaric hypoxia and normoxia in type 1 diabetic patients

Conditions: type1diabetes

Summary: physical activity, along with proper nutrition, is the basis for the behavioral treatment of diabetes. in recent years exercise training in normobaric hypoxia is used in training programs for athletes and in rehabilitation. the aim of this study is the assessment of physical exercise in normobaric hypoxia condition on metabolic control of diabetes: blood glucose profile, its stability, hba1c value, hypoglycemia: frequency, level, severity and time of occurrence, insulin demand, maximal muscle strength level, vo2max and anthropometric parameters.

hypoxia leads to hif-1 production (hypoxia inducible factor 1) which regulates expression of many genes (eg. gene responsible for erythropoetin production). it also stimulates angiogenesis, muscle hypertrophy and glycolytic energy production by transactivating genes involved in extracellular glucose import. before starting the training program all participants will be assessed by cardiologist. then the incremental exercise test will be performed to determine aerobic capacity (vo2max). recruited patients ( type 1 male diabetic patients) will be divided into 2 arms: exercise in normoxia or in normobaric hypoxia. hypoxic chamber is set to contain equivalent to an altitude of 2500 meters above see level (indoor air composition: 15,4% of o2 and 84,7% of n). training program will be the same for all participants: 60 minutes sessions twice a week for 6 weeks of mixed exercise: aerobic and anaerobic. glycemia will be monitored by flash glucose monitoring (free style libre) and the same glucometer model by all patients. at baseline and after 6 weeks: echocardiography, ecg and incremental exercise test, ecg and blood pressure monitoring, lipid profile and diabetes control parameters will be performed in all patients.

Eligibility criteria:
inclusion criteria: * type 1 diabetes of at least 10 years duration * low physical activity * bmi 20-30 kg/m2 * treated with multiple insulin injections (at least 4) or insulin pump (continuous subcutaneous insulin infusion \[csii\]) * negative ecg exercise test * hba1c ≤ 8,0% * high knowledge about functional insulin therapy, carbohydrate counting and diabetes management during exercise * use of advanced glucometer functions and experience in use of free style libre (flash glucose monitoring system, abbott) exclusion criteria: * hba1c \> 8,0%, * advanced complications of diabetes \[pre-proliferative or proliferative retinopathy, and previous laser therapy, microalbuminuria or overt nephropathy, autonomic neuropathy (including lack of elevated heart rate during physical activity)\] * patients physically active (regular physical activities more than once a week), * positive ecg exercise test, history of cardiovascular event or coronary heart disease.
mannitol (aridol) and methacholine (provocholine) responsiveness

Conditions: Asthma

Summary: the study will compare the airway responses to two bronchoconstricting agents, mannitol and methacholine.


Eligibility criteria:
inclusion criteria: * stable controlled asthma exclusion criteria: * pregnancy * use of asthma therapies other than bronchodilator therapy
randomized, blinded, controlled clinical trial of surgically facilitated orthodontic treatment

Conditions: Orthodontic Malocclusion

Summary: the purpose of this investigation is intended to evaluate the efficacy of surgically facilitated orthodontic treatment (sfo) in terms of treatment time, incidence of root shortening, and occurrence of mucogingival side effects compared to conventional orthodontic therapy in patients undergoing orthodontic treatment to correct crowding and/or retroclination of their mandibular anterior dentition.

the null-hypothesis for this research project is that there will be no difference in the rate of orthodontic movement among patients requiring proclination or alignment of their mandibular anterior teeth with sfo (test group) as compared to conventional orthodontic treatment (control group). a null-hypothesis is that there will be no difference between both treatment groups in the occurrence of dental (root shortening) or periodontal (mucogingival defects, alveolar bone resorption) complications associated with orthodontic treatment.

Eligibility criteria:
inclusion criteria: -adults (18-65 y.o.) who seek orthodontic treatment for proclination and/or de-crowding of mandibular anterior teeth. exclusion criteria: * bone-related diseases * previous or current use of biphosphate therapy * previous mucogingival surgery in the area * genetic syndromes, craniofacial anomalies, or cleft lip and/or palate - history of previous orthodontic treatment less than 4 years ago * smoking \>10 cigarettes/day ) * medical history that contraindicates surgical treatment, * people who are not cognitively able to give consent, * pregnancy

Keywords: orthodontics tooth movement bone remodeling mandible osteotomy
is bronchoscopy necessary in the preoperative workup of ggo lung cancer?(ectop-1005)

Conditions: Pulmonary Nodule, Solitary

Summary: this study is one of eastern cooperative thoracic oncology projects (ectop-1005). it aims to evaluate the role of flexible bronchoscopy in the pre-operative workup of ground glass opacity featured lung cancer. all enrolled patients receive the flexible bronchoscopy examination before surgery. investigators observe the intra-bronchial findings of bronchoscopy and the impact of these findings on established surgical plan.

the appropriateness of routine use of bronchoscopy in the operative workup of a solitary pulmonary nodule（spn） is debatable. options expressed in the literature vary from routine preoperative bronchoscopy having no role in obtaining tissue diagnosis in small spns to it begin very useful in determining underlying etiology and surgical strategy. the american college of chest physicians（accp）guidelines recommend bronchoscopy only if air-bronchogram is present or if operator has expertise with newer guided techniques. previous study showed that bronchoscopy is not indicated in spns that present with ground-glass opacity on ct. the purpose of this analysis is to define that role by examining in ggo patients （1）intra-bronchial findings （2）impact of these findings on established surgical plan.

Eligibility criteria:
inclusion criteria: * ground glass opacity pulmonary nodule diagnosed by thoracic ct * karnofsky performance status ≥60 * no surgical contraindication * patients who sign the informed consent * pre-operation clinical stage :t1abcn0m0 * age:18-80 years old exclusion criteria: * central lung tumor diagnosed by ct * tracheal or bronchus deformity diagnosed by ct * tracheal or bronchus disease history * severe smoking history （smoking index ≥400/year）
cervical nags effect on accessory muscles

Conditions: COPD

Summary: the aim of this work is to record changes on accessory muscles especially sternocleidomastoid and scalene after applying cervical nags in copd patients.

natural gliding movements in the spine, known as apophyseal glides, occur during breathing. these movements are believed to be important for maintaining good posture and flexibility in the spine. in copd patients, the muscles that support the spine, like the scalene and scm, can become tight and strained due to labored breathing. this tightness can lead to neck and shoulder pain. while studies suggest that natural apophyseal glides improve spinal mobility, accessory muscle flexibility and reduce pain, there is room for further research on copd patients, especially in pakistan.

Eligibility criteria:
inclusion criteria: * registered with history of moderate (ii) to severe (iii) grade copd (for a minimum of 1 year) will be included in the study. * patients who are clinically stable. exclusion criteria: * patients who have any pre-existing cervical spine disease. * patients who have any cardiac disease. * other respiratory co-morbidities * patients who have severe dizziness or coughing

Keywords: airflow obstruction, chronic chronic airflow obstruction chronic obstructive airway disease chronic obstructive pulmonary disease chronic obstructive lung disease copd coad
study of biomechanical parameters of unloading braces used in the treatment of knee osteoarthritis (bioose)

Conditions: Knee Osteoarthritis

Summary: osteoarthritis is a chronic disease affecting millions of people worldwide, and knee is the second most affected site. knee osteoarthritis is characterized by knee pain, loss of motion, disability, and muscle weakness, all factors contributing to gait alterations, and impacting greatly the patients quality of life. in the absence of curative treatment, pharmacological and non-pharmacological symptomatic treatments are prescribed to maintain this qol, and therefore delay surgery to more appropriate window of opportunity later in life. the aim of the study was to investigate the acute effects of three braces, using different unloading strategies, on gait kinematic and kinetic parameters, as well as pain in patients with medial knee ostoeoarthritis.


Eligibility criteria:
inclusion criteria: * unilateral medial koa classified ii or iii on the kellgren-lawrence scale * varus misalignment with a joint space of at least two finger breadths * pain level equal or higher than 30 mm on a 100 mm visual analog scale * informed written consent exclusion criteria: * limited ability to walk * normoaxial knee alignment * intra-articular injection of a local treatment including corticosteroids in the 3 months or hyaluronic acid in the 6 months preceding its inclusion or analgesic or nsaid treatment with a wash-out period equal to 5 half-lives of the drug concerned * undergoing physiotherapy * cognitive disorders or behavioral disorders (opposition, agitation, dementia) * arteriopathy of the lower limbs * skin disorders contraindicating the wearing of rigid orthotics * severe varicosity preventing the regular wearing of unloading brace