Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of duloxetine, placebo and pelvic floor muscle training in subjects with stress urinary incontinence

Conditions: Urinary Stress Incontinence

Summary: the study is a comparison of the efficacy and safety of duloxetine and pelvic floor muscle training with that of placebo in patients with moderate to severe stress urinary incontinence


Eligibility criteria:
inclusion criteria: * female * between 18 and 75 years of age * confirmed pure genuine stress incontinence * have discrete episodes of incontinence * have pelvic organ prolapse of no greater than stage ii exclusion criteria: * positive urine culture at visit 1 * had formal pfmt with instruction * use of maoi or other excluded medications * use of any anti-incontinence device, vaginal pessaries or any medication prescribed for the treatment of urinary incontinence
investigating the impact of nudging cardiologists to prescribe guideline-directed medical therapy in heart failure patients

Conditions: Heart Failure

Summary: this study investigates the impact of a nudge-based intervention on improving guideline directed medical therapy (gdmt) prescription among cardiologists. using a stepped wedge randomized controlled trial design, we assess whether digital decision support-leveraging home monitoring and clinical data-enhances adherence to guideline-recommended medication titration. the primary outcomes include hf related hospitalization rates and all cause mortality.


Eligibility criteria:
inclusion criteria: * all heart failure diagnoses * \>18 years exclusion criteria: * not understanding the dutch language. * allergies that make uptitration impossible. * admission to hospice or palliative care. * severe psychological disorders.

Keywords: digitial care home monitoring heart failure nudging
correlation analysis of covid-19 igg antibody level in seminal plasma and semen index

Conditions: Covid-19; IgG Antibody; Semen Index

Summary: since december 2019, more and more cases of unexplained pneumonia appeared after exposure to the south china seafood market in wuhan city, hubei province. later, the disease were confirmed to be acute respiratory infectious diseases caused by the 2019 new coronavirus infection. even though we have had great victories in the war against this pandemic, there is still a very large number of deaths early on. as research progresses, vaccines for this infectious disease are already being developed. there are currently two vaccines in widespread use worldwide: mrna vaccines and inactivated vaccines. in china, inactivated vaccines are more commonly used. at present, some studies believe that mrna vaccine does not affect the pregnancy rate and abortion rate of women, but the study sample size is small, and the conclusions are limited. the effects of inactivated vaccines on fertility are still in the blank. we now hope to conduct prospective studies, mainly to study the effect of inactivated vaccine injection on male semen, and whether it has an effect on the quality of embryos in ivf patients


Eligibility criteria:
inclusion criteria: 1. the man's semen quality is normal, 2. the couple meets the indications for ivf, 3. injected with the covid-19 vaccine exclusion criteria: 1. in vitro fertilization due to male factors 2. azoospermia 3. the quality of the man's semen is abnormal 4. unvacced
cd19cd22 car-t therapy in patients with high-risk b acute lymphoblastic leukemia (b-all).

Conditions: B Acute Lymphoblastic Leukemia; Ph-Negative ALL; High Risk Acute Lymphoblastic Leukemia

Summary: clinical trial for the safety and efficacy of induction chemotherapy with va regime and bridging cd19cd22 car-t therapy in adult patients with newly diagnosed high-risk and ph- b-all

to evaluate the safety and efficacy of induction chemotherapy with va regime and bridging cd19cd22 car-t therapy in adult patients with newly diagnosed high-risk and ph- b-all in this prospective, single arm study.

Eligibility criteria:
inclusion criteria: 1. age≥18 and ≤65 years old 2. newly diagnosed and high risk b-all according to the 2022 who classification 3. the immunophenotype of leukemia cells were cd19 and cd22 positive and ph-; 4. anticipated survival time more than 12 weeks; 5. those who voluntarily participated in this trial and provided informed consent. exclusion criteria: 1. history of craniocerebral trauma, conscious disturbance, epilepsy, cerebrovascular ischemia, and cerebrovascular hemorrhagic diseases; 2. electrocardiogram shows prolonged qt interval, severe heart diseases such as severe arrhythmia in the past; 3. pregnant (or lactating) women; 4. patients with severe active infections (excluding simple urinary tract infection and bacterial pharyngitis); 5. human immunodeficiency virus (hiv) positive; active infection of hepatitis b virus or hepatitis c virus 6. previously treated with any car-t cell product or other genetically-modified t cell therapies; 7. creatinine\>2.5mg/dl, or alt / ast \> 3 times of normal amounts, or bilirubin\>2.0 mg/dl; 8. other uncontrolled diseases that were not suitable for this trial; 9. any situations that the investigator believes may increase the risk of patients or interfere with the results of study.
effects of continous positive airway pressure (cpap) in hypertrophic cardiomyopathy

Conditions: Non-obstructive Hypertrophic Cardiomyopathy; Obstructive Hypertrophic Cardiomyopathy

Summary: hypertrophic cardiomyopathy (hcm) is the most common genetic cardiac disease, is a cause of disability including heart failure, atrial fibrillation, and sudden death, with an annual mortality varying from 1% to 6%. obstructive sleep apnea (osa) is extremely common among patients with established cardiovascular disease, including hypertension and atrial fibrillation and when present may contribute to worse cardiovascular outcome. although patients with hcm do not necessarily have typical characteristics of patients with osa, such as obesity and increasing age, there is recent evidence that osa is extremely common among patients with hcm, with a prevalence ranging from 32% to 71%. the presence of osa among patients with hcm is independently associated with worse structural and functional impairment of the heart, including atrial and aorta enlargement, worse new york heart association functional class, and worse quality of life. therefore, the recognition and treatment of osa is a new area of research that may impact in the management of patients with hcm.


Eligibility criteria:
inclusion criteria: * both genders * over 18 years-old * hemodynamically stable * with no other cardiac disease * consent form signed exclusion criteria: * presence of pacemaker * spontaneous withdrawal * previous cardiorespiratory arrest * atrial fibrilation during echocardiography

Keywords: cpap hypertrophic cardiomyopathy blood pressure the focus of the present study is to evaluate the acute hemodynamic effects of cpap in patients with non-obstructive and obstructive hypertrophic cardiomyopathy
improving adherence to covid-19 prevention behaviours: test of persuasive messages

Conditions: COVID-19

Summary: the goal of this randomized online experiment was to test the effectiveness of using various persuasive appeals (deontological moral frame, empathy, identifiable victim, goal proximity, and reciprocity) at improving intentions to adhere to prevention behaviors. participants indicated their intentions to follow public health guidelines, saw one of six flyers featuring a persuasive appeal or no appeal, then rated their intentions a second time. known correlates of attitudes toward public health measures were also measured.

adherence to non-pharmaceutical interventions (npis) for covid-19, including physical distancing, masking, staying home while sick, and avoiding crowded indoor spaces remain critical for limiting the spread of covid-19. this study tests the effectiveness of using various persuasive appeals (deontological moral frame, empathy, identifiable victim, goal proximity, and reciprocity) at improving intentions to adhere to prevention behaviors. a randomized online experiment using a representative sample of adult canadian residents with respect to age, ethnicity, and province of residence was conducted between march 3-6, 2021. participants indicated their intentions to follow public health guidelines, saw one of six flyers featuring a persuasive appeal or no appeal, then rated their intentions a second time. known correlates of attitudes toward public health measures were also measured.

Eligibility criteria:
inclusion criteria: * adult canadian residents * target quotas for province of residence, age, gender, and ethnicity were set to obtain a demographically representative sample based on the 2016 census data exclusion criteria: * province of residence, age, gender, and ethnicity once quotas are filled
noom coach for bariatric surgery

Conditions: Obesity

Summary: the prevalence of overweight in america is a national public health crisis. as more people consider bariatric surgery for the treatment of severe obesity, it is imperative to identify factors influencing surgical outcomes. technology, particularly the noom coach platform, offers a unique opportunity to improve standard interventions utilized in bariatric surgery programs. this study plans to test the efficacy of the noom coach platform on patients' adherence behaviors and psychosocial factors compared to standard care.

overweight and obesity have reached epidemic proportions in the united states. few behavioral treatments are effective for overweight, and bariatric surgery is consequently an increasingly important option. although these procedures produce significantly more weight change than psychosocial treatments, post-operative weight losses vary widely, about 20% of patients clearly experience suboptimal weight loss, and a notable subset of these patients demonstrate substantial weight regain. further, 20-30% report persistence of disturbed eating, depression or anxiety, or impaired health related quality of life. adherence, or "the extent to which a person's behavior coincides with medical or health advice," contributes to variable weight and psychosocial outcomes, as well as failure to follow dietary guidelines, each of which negatively impacts weight loss. the present study, utilizing "noom coach for bariatric health", offers a unique opportunity to overcome obstacles to providing empirically supported treatments and to improve standard interventions utilized in bariatric surgery programs; however, rigorous research on apps is limited, and high-quality, adequately powered, randomized controlled trials with large samples are required. the project will therefore test a combined smartphone app and health coaching system to improve adherence and behavioral outcomes for patients receiving bariatric surgery.

Eligibility criteria:
inclusion criteria: * enrolled in: the mount sinai bariatric surgery program and planning to receive a bariatric procedure. * between the ages of 18 and 60 at entry to the study. * speak english. exclusion criteria: * clinically significant cognitive limitations or history of developmental disability. * history of neurological disorder or injury. * current/lifetime diagnostic and statistical manual of mental disorders (dsm-5) serious psychiatric disorder, such as bipolar disorder, schizophrenia, or psychotic disorder. * acute suicide risk. * current dsm-5 alcohol or substance use disorder. * pregnancy.

Keywords: bariatric surgery mobile health (mhealth) psychosocial functioning obesity weight loss behavioral activation
cell ongrowth and biocompatibility study of two different (hydrophobic acrylic) intraocular lenses: iol xy1 vs. iol xy1a

Conditions: Cataract

Summary: the investigational devices are approved intraocular lenses (iols) intended to be implanted after phacoemulsification in individuals suffering from age-related cataract with the need of cataract surgery. cataract surgery with precedent bilateral randomized iol implantation will be performed in subjects who have signed an informed consent form. postoperative examinations will be implemented in accordance with the approved investigational plan.


Eligibility criteria:
inclusion criteria: * bilateral age-related cataract for which phacoemulsification extraction and posterior iol implantation is planned * age 40 and older * astigmatism of at least 0.75diopters in one eye * normal findings in medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant exclusion criteria: * diabetes mellitus * pseudoexfoliation syndrome * systemical anticoagulation * antiphlogistic therapy * antiglaucomatosa * uncontrolled systemic or ocular disease * preceding ocular surgery or trauma * intraoperative complications * pregnancy/nursing * concurrently participating in any other clinical trial or if they have participated in any other clinical trial during the last 30 days

Keywords: biocompatibility
intra-articular dexmedetomidine: a treatment for chronic knee pain

Conditions: Chronic Knee Pain

Summary: chronic knee osteoarthritis (koa) is a painful condition with limited treatment options. non-pharmacological approaches often fall short, leading to decreased quality of life. ozone therapy, a simple and affordable treatment, has shown promise for pain relief. dexmedetomidine (dex), a sedative and analgesic, has been used successfully as an adjuvant to anesthesia and local anesthetics. given its potential for pain management, exploring dex as a treatment for koa could offer a new and promising approach.


Eligibility criteria:
inclusion criteria: * patients were not assigned for surgical intervention; * patients were free of exclusion criteria exclusion criteria: * patients were assigned for surgical intervention; * patients who had uncontrolled hypertension and/or diabetes mellitus; * patients who had uncompensated cardiac, renal, or hepatic diseases; * patients with coagulopathy, spinal deformity, allergy, or contraindication for the used drugs; * patients who refused to sign the informed consent were excluded from the study.
establishment of clinical basis for hematopoietic growth factors therapy in brain injury

Conditions: Neurological Diseases; Ischemic Stroke; Hemorrhagic Stroke; Cerebral Palsy; Atypical Parkinson Disease

Summary: the purpose of our study is to determine the safety and efficacy of the combination of erythropoietin (epo) and granulocyte-colony stimulating factors (g-csf) in patients with neurological diseases. to be specific, our clinical study is expected that the combination injection of epo and g-csf shows neurotrophic and neuroprotective effects by facilitating endogenous repair process in patients with neurological diseases including stroke, cerebral palsy, or atypical parkinsonism. therefore, we will apply our original treatment technique in patients with neurological diseases, which is expected to overcome current ethical and technical limitations of less evidenced functional recovery, hematological changes, and side effects. eventually, we will establish a comprehensive clinical background about neurotrophic and neuroprotective effects of this hematopoietic growth factors therapy.


Eligibility criteria:
inclusion criteria: * over 20 years old * voluntary participants * neurological diseases including stroke, cerebral palsy, or atypical parkinsonism, at least 3 months after their onset * participants who got previous epo+gcsf injection at least 6 months ago. exclusion criteria: * under 20 years old * participants who can not voluntarily consent * encephalopathy including brain tumor and infection * warfarin (coumadin) medications * leukopenia, thrombocytopenia, polycythemia * malignant diseases, malignant hypertension, myeloproliferative disorder, septic embolism, hyperkalemia * hepatic or renal dysfunction, serum creatinine\>3mg/dl * allergic reactions against to exogenous epo and g-csf * involved in a exclusion criteria for mri test * a women who is pregnant or on breast feeding * body temperature over 38°c * blood pressure over 140/90 mmhg at pre-treatment * blood pressure over 160/100 mmhg during intervention * hb \> 15 g/dl at pre-treatment * hb \> 17 g/dl during intervention * pneumonia detected by x-ray test * recurrent history of aspiration pneumonia

Keywords: hematopoietic growth factors (epo, g-csf), neurological diseases, neurorehabilitation, neurotrophic and neuroprotective effects
effect of beet juice supplementation on vascular and inspiratory muscle function

Conditions: Coronary Artery Disease

Summary: older adults with coronary artery disease (cad) have impaired vascular and inspiratory muscle function. the objective of this study is to examine the effect of beet juice supplementation on vascular and inspiratory muscle function in older adults with cad.


Eligibility criteria:
inclusion criteria: * adults with coronary artery disease (cad) based on an angiogram \>50% stenosis in any major epicardial vessel or history of myocardial infarction or history of coronary revascularization. * considered to have stable cad on optimal medical therapy * 60 to 85 years of age * men and women (women must be postmenopausal either natural or surgical) * able to give consent exclusion criteria: * ejection fraction \<50%, unstable angina, recent myocardial infarction within 6 months * coronary revascularization, including percutaneous coronary intervention and coronary artery bypass graft or thoracic surgery within 6 months. * stroke, obstructive pulmonary disease, hepatitis b, c, hiv, seizures, or other relevant on-going or recurrent illness * individuals that have participated in respiratory training within the last 12 months or cardiac rehabilitation within the last 6 months * uncontrolled hypertension * use of tobacco products including smoking traditional or e-cigarettes * use of hormone replacement therapy in women or men (e.g., estrogen, progesterone or testosterone) * regular aerobic exercise training * unwilling to stop using mouthwash at least 1 week before the start of the study and during study participation * unwilling to remain weight stable during study participation
the validity and reliability study of turkish version of calgary sleep apnea quality of life index

Conditions: Obstruvtive Sleep Apnea Syndrome (OSAS)

Summary: the aim of this study is to investigate its validity and reliability of the questionarre whose original english name was "calgary sleep apnea quality of life index" which we plan to translate into turkish as sleep apnea quality of life index.


Eligibility criteria:
inclusion criteria: * age ≥18 * apnea hypopnea index (ahi) of ≥5 exclusion criteria: * presence of sleep disturbances other than osas * presence of active alcohol or drug addiction * psychiatric impairment * cognitive impairment * recent acute illness (such as myocardial infarction) that may adversely affect their quality of life * difficulty in communicating
(3d) ultrasound imaging liver and kidney

Conditions: Liver Cancer; Kidney Cancer

Summary: this study is to assess the addition of 3d ultrasound guidance during standard care ablation or biopsies of liver or kidney tumours. 3d ultrasound only differs from conventional 2d ultrasound in that the ultrasound transducer is mounted on a special assembly that moves the transducer in precise, stepped movements while a succession of 2d images are collected by the computer. special software written specifically for 3d ultrasound precisely aligns these 2d images into a 3-demensional volume , allowing area in question to be viewed in many different planes. 3d ultrasound is a safe, fast, non-invasive imaging procedure. ultrasound images will be checked against the pre- and post- procedure ct images to make sure the tumours were completely removed or properly targeted during biopsy.

images will be acquired by a physician on patients who are undergoing a liver or kidney ablation or biopsy procedure who are well enough to provide consent. patients will be imaged during the ablation procedure according to the standard of care, and subsequent analysis will commence following the acquisition. the devices being used are all property of the lhsc health network that have been licensed for clinical use through health canada. in addition, 3d ultrasound only differs from conventional 2d ultrasound in that the ultrasound transducer is mounted on a special assembly that moves the transducer in precise, stepped movements while a succession of 2d images are collected by the computer. special software written specifically for 3d ultrasound precisely aligns these 2d images into a 3-dimensional volume, allowing the area in question to be viewed in different planes. the clinical 2d an d3d ultrasound images will be checked against the pre- and post- procedure ct images to make sure the tumours were completely removed.

Eligibility criteria:
inclusion criteria: * • patients who are scheduled for standard care liver or kidney ablation or biopsy exclusion criteria: * none

Keywords: diagnostic intervention 3d ultrasound
contrast the role of avitene and ok-432 in reducing seroma formation after axillary lymphadenectomy for breast cancer

Conditions: Drainage; Postoperative Complications

Summary: after axillary lymphadenectomy for breast cancer there are not few patients showed seroma formation and it can not be ignored.investigators aimed to study two new methods of application of microfibrillar collagen hemostat flour and ok-432 to reduce seroma formation and to verify the efficacy and safety of these two applications.try to prove them as beneficial supplements for axillary lymphadenectomy of breast cancer.

a prospective,randomized analysis of breast-conserving surgery or mastectomy plus axillary lymphadenectomy for those patients with sentinel node positive using microfibrillar collagen hemostat flour 、 ok-432 or using nothing in equal probability.up to 12 months,a total of 180 will be recruited in plan.during the operation and after the axillary lymphadenectomy，according the arms，investigators put microfibrillar collagen hemostat flour（avitene）、 ok-432（sapylin） or nothing into patients axillary wounds。and investigators will the statistical significance of these three arms that the postoperative drainage magnitude and duration.also the complications associated with axillary lymphadenectomy will be studied.

Eligibility criteria:
inclusion criteria: 1. patients volunteered for the study and signed informed consent； 2. preoperative biopsy or intraoperative sentinel lymph node biopsy confirmed axillary lymph node metastasis and need axillary lymphadenectomy 3. no penicillin allergy 4. no blood system diseases 5. no rheumatic heart disease 6. no history or family history of asthma 7. no history of axillary surgery exclusion criteria: 1. a history of severe hypertension 2. a history of diabetes 3. undergoing anticoagulant therapy or anticoagulant therapy drug withdrawal less than a year 4. bmi\>30 5. can not accept telephone follow-up or can not go to the hospital for subsequent inspection treatment