Kornimate/medical-research-clean huggingface dataset:
massachusetts general hospital evaluation of depuy asr hip system

Conditions: Osteoarthritis

Summary: depuy orthopaedics has issued a voluntary recall of the asr hip replacement system due to a higher than expected revision rate reported in the england/wales and australian national joint registries. there are two types of asr hip implants used for total hip replacement surgery: * asr xl hip system * asr hip resurfacing system massachusetts general hospital (mgh) in boston, usa is the study sponsor. mgh is conducting this study with the help of funding from depuy orthopaedics. mgh will collect and analyze clinical information from 5,000 subjects around the world. the countries include the united states of america, australia, south africa, england, denmark, finland and sweden. mgh will collect and analyze blood test results, x-rays, soft tissue imaging and how well the asr hips are functioning. mgh will analyze the data annually for 6 years. the purpose of this study is to follow patients who have the asr hip system for the next 6 years. the findings of this study may help surgeons to make better informed decisions about monitoring and treatment of patients with asr hip systems.

description of the subject population: * adults who have previously undergone a surgery implanting the depuy asr xl acetabular hip system or asr hip resurfacing system; * asr patients who are already being followed-up by their surgeon at least once a year. this routine follow-up care consists of a clinic visit, blood tests, x-rays and possibly an mri, ultrasound or ct scan.

Eligibility criteria:
inclusion criteria 1. any patient with on-label use of the asr-xl or asr component system currently implanted. 2. able to provide informed consent previously approved by institution's institutional review board (irb) or ethics committee (ec). 3. able to return for follow-up. 4. able to complete the required patient reported outcome measures. exclusion criteria 1. any patient with off-label use indications for the asr-xl or asr component system. 2. any patient who received the asr-xl implant as a result of a hip resurfacing conversion or a revision tha. 3. subjects with difficulty in comprehending the informed consent form for any reason. 4. the subject refuses to allow their medical records to be inspected by the sponsor, representatives of the sponsor, or the medical office staff.

Keywords: metal on metal hip replacement asr depuy
pair antiplatelet therapy in ischemic stroke with intracranial artery stenosis

Conditions: Ischemic Stroke; Intracranial Arteriosclerosis; Secondary Prevention; Antiplatelet Drug

Summary: the goal of this clinical trial is to learn about efficacy and safety of dual antiplatelet therapy in ischemic stroke with intracranial artery stenosis. the main question it aims to answer are: whether aspirin combined with clopidogrel for 3 month is better than 1 months for patients with non-cardiogenic cerebral infarction with intracranial artery stenosis. participants will get dual antiplatelet therapy (aspirin plus clopidogrel) for 1 month or 3 months within 7 days of the first stroke. researchers will compare experimental group (3 months dual antiplatelet therapy) with comparison group (1 month dual antiplatelet therapy), to see if experimental group would reduce stroke recurrence or mortality, and increase bleeding and other adverse prognosis.


Eligibility criteria:
inclusion criteria: 1. age 40 \~ 80 years old; 2. patients diagnosed as non-cardiogenic cerebral infarction according to the who definition of stroke, with mra/cta/dsa confirmed intracranial artery stenosis ≥50% (intracranial carotid artery, m1 and proximal m2 segment of middle cerebral artery, a1 and a2 segment of anterior cerebral artery, p1 and p2 segment of posterior cerebral artery, intracranial vertebral artery and basilar artery); 3. first stroke onset within 7 days; 4. nihss score ≤5; 5. patients or family members sign informed consent forms; exclusion criteria: 1. patients receiving thrombolysis or endovascular therapy; 2. patients with recurrent stroke; 3. patients has undergone major surgery or major trauma within the past 30 days; 4. history of gastrointestinal bleeding, active peptic ulcer, intracranial hemorrhage or other hemorrhagic diseases; 5. contraindications or intolerances to the use of antiplatelet therapeutics; 6. platelet count \<100\*109/l, hemoglobin\<110g/l; 7. patients with severe organ insufficiency or other serious disease (e.g., severe cardiopulmonary failure, advanced tumor, severe dementia); 8. patients intolerant to mri scan are replaced by ct or dsa; 9. poor compliance, unable to meet the requirements of the study.
short course radiation therapy in palliative treatment of pelvic cancer

Conditions: Pelvic Cancer; Radiotherapy; Palliative Care

Summary: aim of the study is to assess efficacy of a short course radiation treatment in patients with symptomatic pelvic malignant lesions

standard treatment for pelvic lesions (300 cgy in 10 daily fractions of 300 cgy each) is compared with experimental treatment (2000 cgy in 4 fractions of 500 cgy twice a day) to demonstrate non-inferiority of this scheme

Eligibility criteria:
inclusion criteria: * symptomatic pelvic malignant lesions (primary solid tumors or metastases from solid tumor) * age \> 18 years * eastern cooperative oncology group (ecog) performance status 0-3 * no changes in supportive care in the week before radiotherapy exclusion criteria: * pregnancy * previous irradiation of the same region

Keywords: short course radiotherapy symptomatic pelvic lesions
better understand end-of-life emergencies' management among elderly in nursing homes: a pilot study in brittany, france

Conditions: Died; in End-of-life Situation

Summary: the purposes of this study are : * to know and to understand frequency and variability (quantitative and qualitative) of end-of-life emergencies in nursing homes. * to know and to understand practices applied in these situations depending on the institution and the different reasons of hospital use. * to know and to understand the practical and organizational elements, in nursing homes, that can determine a (re) hospitalization or an end-of-life


Eligibility criteria:
inclusion criteria: * dead residents during the quarter preceding the date of the survey or * residents in end-of-life situation the day of the survey, as determined by the physician coordinator of nursing homes (we will use the definition of "terminal condition" contained in the guide of the cnsa (coding pathos - april 2011)). exclusion criteria: * patients opposing the study, * patients aged below 18 year old
dbs of the third ventricle for cluster headache and obesity

Conditions: Cluster Headache; Obesity

Summary: study of deep brain stimulation of the third ventricle in cluster headache and obesity treatment.


Eligibility criteria:
inclusion criteria : * male or female aged between 18 and 65 years * ambulatory or hospitalized monitoring * fluent in french and able to understand the study procedures, including completing the auto-questionnaires * registered in the french social security scheme * signed informed consent of the patient will be collected before inclusion in the study * cluster headache or obesity patients exclusion criteria: * contraindication to magnetoencephalography (meg) and/or electroencephalography (eeg) * contraindication to magnetic resonance imaging (mri) * all categories of protected persons
unveiling preclinical idiopathic macular hole formation

Conditions: Idiopathic Macular Hole

Summary: a macular hole is a rupture in the macula. in terms of pathogenesis, as much as 80% are idiopathic (idiopathic macular hole, imh). the normal incidence of this condition is about 0.17%; however, there is a 10-29% chance of development of a macular hole in the fellow eye of patients suffering from unilateral macular hole. our hypothesis is that embedded in the topography of the retina is information that can allow for discrimination between healthy eyes and eyes with an increased risk of developing imh. as such, our work aims to develop a system that allows the automatic identification of these eyes.

a macular hole is a rupture in the macula, the central portion of the retina, responsible for sharp, central vision and hence indispensable for most tasks. in terms of pathogenesis, even though some can be related to trauma, as much as 80% are idiopathic (idiopathic macular hole, imh). it is theorized that antero-posterior and tangential forces are behind this condition; however, no conclusions have been reached. while the normal incidence of this condition is about 0.17%, there is a 10-29% chance of developing a macular hole in the fellow eye of patients suffering from unilateral macular hole. our working hypothesis is that embedded in the topography of the retina is information that can allow for discrimination between healthy eyes and eyes with an increased risk of developing imh. as such, our study consists on the characterisation of the retinal topography of fellow eyes of patients with unilateral imh but no other visible retinal pathologies, and of eyes from controls subjects in the same approximate age group. from these topographic maps we acquire a series of features (parameters), and using machine learning techniques create a system that separates eyes into one of the groups - healthy or at risk.

Eligibility criteria:
inclusion criteria: * normal oct, with or without vitreous adhesion * fellow group: unilateral idiopathic macular hole exclusion criteria: * oct with vitreous adhesion * lamellar or pseudoholes * inner retinal surface alterations * myopia(\>4d) * glaucoma * significative media opacity * previous retina photocoagulation * any type of intraocular surgery in the last 6 months * intravitreal medication * diabetes or neurodegenerative diseases * macular hole secondary to trauma

Keywords: idiopathic macular hole
prevalence of h.pylori in patients with acne vulgaris acne vulgaris

Conditions: Helicobacter Pylori Infection; Acne Vulgaris

Summary: the objective of the study is to investigate prevalence of h.pylori infection among acne vulgaris patients.

the study included patients with acne vulgaris and healthy control participants. the study recruited both sexes, all grades of acne, adolescents and young adults. all patients were subjected to complete history, general and skin examination acne vlugaris patients were classified into mild, moderate and severe according to the classification of american academy of dermatology for acne vulgaris. detection of h. pylori infection: blood and stool samples were taken from each participant and was directly transferred to laboratory for detection of h. pylori antigen and antibody. an enzyme-linked immune sorbent assay (elisa) was used for quantitative assessment of igg antibodies against h.pylori in human serum. a monoclonal antibodies based enzyme-linked immunosorbent assay was used to detect h.pylori specific antigen in stool samples.

Eligibility criteria:
inclusion criteria: * acne vulgaris patients * healthy volunteers (control) exclusion criteria: * patients with a history of drug intake that affects h. pylori such as proton-pump inhibitors, clarithromycin, tetracyclines, amoxicillin or metronidazole within previous two weeks were excluded.

Keywords: acne vlugaris prevalence helicobacter pylori
enhancing motivation in recent onset schizophrenia

Conditions: Schizophrenia

Summary: this project will result in the development of a personalized intervention strategy to improve motivation for treatment engagement and functional outcomes in individuals with a recent onset of schizophrenia. motivational impairment is arguably the single most important factor that determines a patient's ability to engage in and adhere to effective treatment. in our study, sixty participants will be enrolled in a randomized controlled trial comparing the feasibility and tolerability of two types of motivational interventions (daily goals or prime), and a neuroplasticity-based cognitive training program. participants are randomized to either receive daily goals or prime for 8 weeks, after which, both conditions will also receive an 8-week course of cognitive training delivered via ipads. participants will undergo pre/post-testing and a 6-month follow-up to determine feasibility and efficacy of the interventions. by enhancing motivation, schizophrenia patients would be able to engage more fully with treatment and develop full and productive lives. this study may also pave the way forward for other health conditions in which motivational impairments impede health outcomes. all assessments will be conducted at the university of california, san francisco; however, we offer some assessments to be done remotely.


Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia, schizoaffective, or schizophreniform disorder. * onset of diagnosis within 5 years. * 14-30 years old. * clinically stable (outpatient status for 1 month and stable dose of medication for 1 month). * good general health exclusion criteria: * substance dependence within the past 12 months, * current substance abuse, * no history of neurological disorder
optical frequency domain imaging for assessing colonic polyps

Conditions: Colonic Polyps

Summary: the goal of this research is to conduct a pilot clinical study to image colonic polyps with the intent to evaluate the potential use of optical frequency domain imaging (ofdi) to identify the extent of invasion (if present), differentiate between hyperplastic polyps and adenomas, and identify serrated polyps.

the colon ofdi catheter will be used in conjunction with a sigmoidoscope. if a sigmoid polyp is identified, the colonoscope will be removed and a sigmoidoscope inserted. the colon ofdi catheter will be advanced through the sigmoidoscope accessory port and positioned adjacent to the colon wall. imaging will be performed with the ofdi system across the polyp's surface and the base/stalk if pedunculated. the investigators anticipate that on average the investigators will utilize 4 helical scans per polyp. each of the scans will take less than 30 seconds.

Eligibility criteria:
inclusion criteria: * patients undergoing a screening colonoscopy * patients must be over the age of 18 * patient must be able to give informed consent exclusion criteria: * patients with hemostasis disorders * patients taking any anti-coagulants such as coumadin or plavix,

Keywords: colonic polyps oct imaging colon polyp
tiptraq home sleep test study, shh

Conditions: Obstructive Sleep Apnea

Summary: the clinical study aims to develop and validate the tiptraq system, created by pranaq, a home sleep test for sleep apnea screening. the system comprises a wearable device and a cloud-based ai for estimating total sleep time (tst) and apnea-hypopnea index (ahi).

sleep-disordered breathing is a common disease that affects life function and quality of life, and it also imposes a great burden on the public health system. obstructive sleep apnea accounts for the largest proportion of sleep-disordered breathing, and because of the oriental facial structure, the prevalence of sleep-disordered breathing is relatively high. the current gold standard for diagnosis osa is polysomnography (psg). although the physiological information collected by psg is complete and detailed, it requires a considerable amount of manpower and medical resources, and changes in the sleep environment also cause bias in the accuracy of inspection. so far, the tools for simple and accurate screening and diagnosis osa are relatively limited. in this study, tiptraq, a wearable device developed by pranaq, was used to collect photoplethysmography (ppg) of patients during the night of psg inspection. the reliability and validity analysis was carried out by comparing with the corresponding indicators of psg, and the feasibility of tiptraq as a tool for home sleep test (hst).

Eligibility criteria:
inclusion criteria: subjects from the age of 20 and older that have an indication for an in-lab psg study. exclusion criteria: * heart transplant * heart failure, new youk heart association (nyha) classification iii or iv * chronic opioid medication user * devastating severe strokes, with the modified rankin score (mrs)≥4 * tracheostomy * incapable of comprehending and signing the informed consent and questionnaires, including but not limited to subjects with severe alzheimer's, unconscious by head trauma, or of someone with limited mental capacity * cannot correctly follow the order to use the tiptraq device

Keywords: obstructive sleep apnea
tumorapa 1: efficacy of rapamycin in secondary prevention of skin cancers in kidney transplant recipients

Conditions: Skin Cancer; Kidney Transplantation

Summary: in a population of kidney transplant recipients having developed a first squamous cell carcinoma, the aim of the study is to assess the incidence of subsequent skin cancers over 2 years in patients who are switched to rapamycin as compared to patients who are maintained under calcineurin inhibitors.


Eligibility criteria:
inclusion criteria: * first post-transplant squamous cell carcinoma in a kidney transplant recipient under calcineurin inhibitors exclusion criteria: * other squamous cell carcinomas in the past history * more than 2 transplantations * patients not under calcineurin inhibitors * unstable graft function * non controlled hyperlipidemia (cholesterol \> 7.8 mmol/l or triglycerides \> 3.95 mmol/l) * leucopenia \< 3000/mm3 * thrombocytopenia \< 100,000/mm3 * liver dysfunction * pregnancy * allergy to macrolides

Keywords: squamous cell carcinoma kidney transplant recipients rapamycin skin cancers in kidney transplant recipients
an investigation of chemotherapy induced cognitive impairments in breast cancer survivors

Conditions: Breast Cancer

Summary: the main goal of this project is to identify and remediate the cognitive difficulties, including processing speed and attention deficits in individuals who have undergone chemotherapy treatment. recent research has demonstrated objective cognitive deficits following chemotherapy and that it is not an emotional reaction to the cancer diagnosis as it was once considered. there are a large number of woman diagnosed and treated for breast cancer that experience chemotherapy induced cognitive deficits. subjects who participate in the study will be evaluated for cognitive abilities prior to chemotherapy treatment and after completion of chemotherapy. participants will then have the option to participate in the second phase of the study, which involves the use of a computer-based brain fitness program for 12 weeks. this is followed by another cognitive evaluation.


Eligibility criteria:
inclusion criteria: 1. diagnosis of breast cancer with adjuvant chemotherapy treatment 2. all subjects will be between the ages of 18 and 70 years old 3. free from significant psychiatric history 4. free of current alcohol or drug abuse. 5. all participants need to understand and read english and have the capacity to consent. exclusion criteria: 1. individuals with pre-exiting neurological disorder (i.e. brain tumors, dementia, parkinson's disease, multiple sclerosis, seizure disorder) or diagnosed with metastasis cancer. 2. individuals younger than 18 years old and older than 70 years old will also be excluded due to developmental changes that occur in those years. 3. individuals with a current substance use disorder will also be excluded. 4. individuals who lack the capacity to consent will be excluded from this study.

Keywords: post-chemotherapy cognitive impairment
large burn outcome study

Conditions: Burns

Summary: to examine long term physical and psychosocial outcomes of pediatric burn survivors. we want to learn about thoughts, feelings, coping style, social support, and overall adjustment following burn injury.

to evaluate the long term quality of life of adolescents and adults who suffered severe pediatric burns. this study will include an array of physical and psychosocial assessments, thus providing a unique and complete set of information on the long term outcomes in this population.

Eligibility criteria:
inclusion criteria: * at least 60% third degree total body surface area * acute burn treatment at shriners burns hospital for children - galveston between 1986-2005 * three years post injury * current age of at least 16 years exclusion criteria:

Keywords: burn injury burn recovery
non-use after stroke: influence of applied force and precision when reaching with the paretic upper limb

Conditions: Stroke

Summary: after a stroke, 80% of patients have an upper limb deficit, limiting activity. some develop a non-use: they can, but do not, use their paretic limb. non-use is a general phenomenon applied to all situations where the patient applies unnecessary compensation. several rehabilitation techniques are effective to counter non-use, but there is insufficient knowledge to choose the most suitable technique. optimal control theory could help guide these choices. it assumes that the chosen coordination satisfies the constraints of the task (force, amplitude, tolerance) while reducing the cost of the movement. this study will assess non-use by anticipating the sensitivity to the constraints of force and precision deduced from the logic of optimal control. the study authors expect to observe a weakness effect: in a reaching task (i.e. when the person has to touch an object placed in front of them), lightening the paretic arm makes it possible to reduce non-use, and a precision effect: in a reaching task, non-use increases with the required spatial precision.


Eligibility criteria:
inclusion criteria: inclusion criteria specific to the stroke group: * patient having had a 1st stroke * patient whose stroke occurred more than a month ago. * patient having had a supratentorial stroke * patient able to touch the opposite knee with the paretic arm inclusion criteria specific to the control group: * subject who has never had a stroke * subject without motor or orthopedic impairment of the upper limbs and in particular of the shoulder general inclusion criteria: * subject who has given free and informed consent. * subject who signed the consent form. * subject affiliated or beneficiary of a health insurance plan. exclusion criteria: * pregnant, parturient or breastfeeding subject. * the subject is participating in a category 1 interventional study, or is in a period of exclusion determined by a previous study * the subject refuses to sign the consent * it is impossible to give the subject informed information * the patient is under safeguard of justice or state guardianship * patient with cognitive disorders incompatible with a good understanding of the use of the device * patient with other neurological or osteoarticular history that may limit the performance of the task - criterion left to the deiscretion of the investigator

Keywords: non-use compensation weakness optimal control