Kornimate/medical-research-clean huggingface dataset:
effect of mrp with and without ems on gait, functional independence and qol in stroke patients

Conditions: Stroke

Summary: to determine the effects of motor relearning programme with and without electrical muscle stimulation on gait, functional independence and quality of life in hemiplegic stroke patients.

a study was performed a motor relearning program in stroke survivors. a clinically significant improvement was found in the motor relearning groups, and only in one study is this improvement significant compared to another intervention. neuromuscular electrical stimulation improves activities of daily living post-stroke. while the potential for enhancing functional motor ability seems less clear, the current systematic review and meta analysis's results point to a significant positive impact of nmes on adl function during the post stroke rehabilitation process. people with hemiparesis who received both conventional treatment and interventions based on motor relearning showed a significant improvement in their level of disability. there were no appreciable gains in the hrqol perception. many research investigations have been carried out to assess the effects of motor relearning programs with regard to specific functional aspects and physical deficiencies. up to the researcher's knowledge, there is no data to assess the effects of electrical muscle stimulation along with motor relearning programs in stroke patients. therefore, the purpose of this study is to compare how a motor relearning program with and without electrical muscle stimulation affects hemiplegic stroke patients' gait, level of functional independence, and quality of life.

Eligibility criteria:
inclusion criteria: * diagnosed as hemiplegic stroke * age between 45-65 years * both males and females * mini-mental state examination score ≥24 * able to stand independently for at least 1 min and (5) can ambulate 25 feet/10 m (with or without the assistive device) exclusion criteria: * experiencing balance problems as a result of neurological conditions other than stroke (for instance cerebellar impairment, inner ear dysfunction, or parkinson's disease) * fixed ankle or foot contracture. * a serious cardiac disease (aorta stenosis, angina, hypertrophic cardiomyopathy, arrhythmia and pacemakers). * congenital limb deformities

Keywords: gait functional independence quality of life
advanced surgical simulation processes in the correction of skeletal defects and deformities

Conditions: Musculoskeletal Deformity; Musculoskeletal Abnormalities; Musculoskeletal Disorder

Summary: virtual surgical planning (vsp), computer-aided surgical simulation (cass) for bone corrections, and the customization of implants and devices through 3d printing, known as patient-specific instruments (psi) and graft-specific instruments (gsi), are assuming increasingly central roles in orthopedic clinical and surgical practice. one area witnessing notable advancement is the treatment of musculoskeletal disorders (mms) in children, adolescents, and young adults. these disorders involve severe and rare abnormalities in skeletal formation and development across three-dimensional planes, often affecting multiple limbs. managing such deformities is complex, challenging to standardize, and prone to unpredictable clinical, radiographic, and functional outcomes. the application of 3d modeling and printing technologies offers a deeper understanding of deformities and facilitates improved prediction, precision, reproducibility, and safety in surgical interventions. the musculoskeletal apparatus network (rams network) centers are equipped with advanced 3d laboratories for surgical simulation and planning, aligned with the overarching goal of improving surgery quality through "in-silico" medicine (ism) principles. at present, numerous complex surgeries involving virtual surgical planning (vsp) and sterilizable 3d-printed patient-specific instruments (psi) and/or graft-specific instruments (gsi) are being simulated and performed at the rizzoli institute. preliminary data from previous protocols indicate a significant reduction in surgical time with the implementation of vsp and the utilization of psi and gsi. the aim of this study is to enhance the current process of simulating, planning, and designing surgical support tools within 3d printing point-of-care (3d poc) facilities. to achieve this, it is imperative to expand case volumes and systematically organize, categorize, and standardize simulation and planning procedures.


Eligibility criteria:
inclusion criteria: * diagnosis of musculoskeletal disease (msd) of the limbs; * need for mono- or polyaxial correction by one or more osteotomies; * presence of specific consent to participate in the trial; exclusion criteria: * patients who refuse to participate in the study * patients who do not undergo radiological follow-up examinations for vsp or for whom the radiological record is insufficient to conduct vsp; * patients who undergo different interventions for correction of msd (growth modulation interventions by epiphysiodesis and hemiepiphysiodesis, progressive correction by external circular/hexapodal fixation); * pregnant or lactating women

Keywords: virtual surgical planning patient-specific instrument graft-specific instrument pediatric orthopedics
fecal metagenomics and metabolomics analyses to identify potential screening biomarkers for colorectal polyps and cancer in chinese population

Conditions: Colorectal Cancer; Colorectal Polyp; Mass Screening; Gastrointestinal Microbiome

Summary: many previous studies had revealed that gastrointestinal microbiome is changed compositionally and ecologically in patients with colorectal cancer comparing with healthy population. these finding provide us with a new sight to take advantage of gut microbiota. the current study aims to explore new potential biomarkers for early screening and prognostic prediction of colorectal cancer and colorectal polyps by analyzing metagenomics and metabolomics of gut microbiota.

patients who come to the sixth affiliated hospital, sun yat-sen university for medical purposes will be invited to participate in the study. participants will be asked to collect two stool samples. one stool sample will be used for metagenomic sequencing and the other will be used to extract metabolomics data. meanwhile, participants will be asked to complete a questionnaire about lifestyle and diet habits with the assistance of a well-trained nurse. we will delineate the community and metabolites differences in the gut microbiota between colorectal cancer patients and healthy populations by comparing cases with controls. considering the different gut microbiota profiles among different populations caused by varied diet habits and lifestyles, the current study will try to describe the microbiota profiles in the chinese population. besides, we will explore new potential biomarkers for early screening and prognostic prediction which is suitable to chinese populations. moreover, we will attempt to find out the interactions between diet and microbiota through a comprehensive analysis of the questionnaire and the collected results.

Eligibility criteria:
inclusion criteria: 1. participants aged 18 to 80 years old. 2. participants who had been diagnosed with colorectal cancer or advanced colorectal polyps for the first time according to pathology results. 3. participants who had signed informed consent. 4. participants must have the ability to complete the questionnaires of the study. exclusion criteria: 1. participants who had a positive personal history of colorectal polyps. 2. participants who had a positive personal history of colorectal cancer. 3. participants who had a positive personal history of other gastrointestinal diseases, such as inflammatory bowel disease， intestinal tuberculosis, or irritable bowel syndrome. 4. participants who had undergone a colonoscopy or other procedure requiring bowel preparation in the last two months. 5. participants who had been hospitalized for any reason in the last two months. 6. participants who had consumed antibiotics for any reason in the last three months. 7. participants who had consumed prebiotic supplements regularly in the last year. 8. participants who had other physical conditions that didn't suitable to participate in the study, such as severe cardiovascular diseases, serious mental illness, or pregnant status.
npwt in patients undergoing surgical procedures for management of gi malignancies

Conditions: Surgical Wound Infection

Summary: this randomized trial will use a negative pressure wound therapy device or standard wound closure, in participants with gastrointestinal neoplasms, to measure the rate of surgical site infections


Eligibility criteria:
inclusion criteria: * scheduled surgical procedure for the management of gastrointestinal cancer * scheduled surgical procedure planned for incision that will result in wound \>5cm * scheduled surgical procedure planned for skin wound that will be closed by primary intention with either: staples covered by sterile telfa® and tegaderm® or medipore® or dermal or subcuticular sutures covered by octil® * provision of signed and dated informed consent form * stated willingness to comply with all study procedures and availability for the duration of the study exclusion criteria: * scheduled surgical procedure where wound considered dirty * scheduled surgical procedure for wound left for closure by secondary intention * emergency surgery * pregnancy. pregnancy status is confirmed per protocol the day of surgery in the preoperative space by urine pregnancy test in patient younger than 65 and with intact uterus. pregnant patient will be excluded from this study * history or current diagnosis of any medical or psychological condition that in the investigator's opinion, might interfere with the subject's ability to participate in the study or the inability to obtain informed consent because of psychiatric or complicating medical problems
a study with ruxolitinib phosphate cream applied topically to subjects with alopecia areata (aa)

Conditions: Alopecia Areata

Summary: a phase 2 study to find out if the drug ruxolitinib phosphate cream is safe and has beneficial effects in people who have alopecia areata (partial or complete hair loss) when applied to the skin.


Eligibility criteria:
inclusion criteria: * diagnosis of aa * duration and extent of current episode of aa * evidence of active hair loss exclusion criteria: * evidence of diffuse, spontaneous terminal hair regrowth * receipt of treatment known to potentially affect the course of aa within last month

Keywords: hair loss alopecia areata alopecia totalis alopecia universalis jak inhibitors topical hair growth
weight loss interventions in obese patients with stages 3-4 chronic kidney disease: a randomised controlled trial

Conditions: Chronic Kidney Disease; Obesity

Summary: weight loss surgery is the most effective weight loss treatment available, but the direct effect on chronic kidney disease is less widely understood. early research shows some improvement in kidney function may occur and candidacy for kidney transplantation can be improved with weight loss following surgery. to date, no randomised controlled trial has been performed to examine the effect of weight loss surgery on the progression of chronic kidney disease. this randomised trial will allocate patients to either lifestyle modification with diet, exercise and pharmacotherapy, or weight loss surgery to remove two thirds of the stomach using the laparoscopic sleeve gastrectomy procedure. this study aims to evaluate weight loss surgery vs lifestyle modification in patients with chronic kidney disease with estimated kidney function of 20-60% and morbid obesity (bmi 35-45) in terms of kidney function, cardiovascular disease risk factors and all-cause mortality.


Eligibility criteria:
inclusion criteria: * stages 3-4 ckd patients (gfr 20-60 ml/min) * male or female * bmi 35-45 kg/m2 * aged \>18 years * previously attempted weight loss * fit or anesthesia and surgery * written informed consent exclusion criteria: * pregnancy * history of chronic liver disease * previous gastric surgery or large hiatus hernia * previous bariatric surgery * psychiatric illness, including anxiety, mood and untreated eating disorders * malnutrition (assessed by subjective global assessment) * infection or course of antibiotics within the last month * unwilling to consider surgical treatment * previous kidney transplant

Keywords: obesity bariatric surgery chronic kidney disease weight loss exercise
prostate cancer detection screening mri protocol

Conditions: Prostate Cancer

Summary: whether a quantitative detection specfic magnetic resonance imaging (mri) protocol improves prostate cancer (pca) detection in biopsy naïve men is not adequately studied.

this will be a 2 arm prospective clinical trial. men with clinical suspicion for pca but no prior prostate biopsy will be enrolled from the university of illinois (ui) health urology clinics. all eligible men will be screened and enrolled by the clinical research coordinator. enrolled men will undergo detection protocol mri at the uic advanced imaging center (aic) prior to diagnostic biopsy. the mri will be processed by the study team and evaluated for areas suspicious for high grade pca by a board certified clinical radiologist. subjects with mri with no suspicious areas for high grade pca will undergo standard of care (soc) core transrectal ultrasound (trus) biopsy. subject with mri suspicious for high grade pca will have 2-4 biopsies guided toward each suspicious lesion using mri/trus fusion biopsies (maximum of 12 cores). all biopsies will undergo soc histologic processing and interpretation in pathology. biopsy results will be communicated to the patients by the urologist performing the biopsy and all additional management will be soc. this visit will signify the end of the study

Eligibility criteria:
inclusion criteria: * adult men between 18 and 80 years of age * suspected pca as defined by elevated psa ≥4 ng/ml and ≤20 ng/ml and/or abnormal dre as determined by a physician * ability to provide informed consent exclusion criteria: * prior prostate biopsy * prior diagnosis of pca * mri incompatible implanted medical devices or foreign bodies * rectal anatomy incompatible with trus biopsy * life expectancy \<10 years as determined by the treating urologist
health promotion intervention to reduce child morbidity

Conditions: Diarrhea; Nutritional

Summary: while household-level water, sanitation and hygiene has been investigated extensively, this is the first comprehensive study to investigate the impact of improved water, sanitation and hygiene and nutrition at household on child health in yemen.

this study was conducted in hufash district, al-mahweet province, which is located on the southwest of the capital sana'a, and takes about (113)kilometers from it. the study aimed to highlight the key role of the community based interventions in reducing child morbidity and mortality in rural yemen.a community - randomized controlled field trail was implemented to evaluate the role of public health promotion on reducing child diarrhea, acute respiratory infection, nutrition, immunization in children under age of five at enrollment over a six month of study period. due to the nature of the study, blinding is not possible so some measures would be done to reduce the non-blinding bias like, to keep the study staff blinded as much as possible, the observers and survey staff were not informed about the study design. the sample size required to measure the primary and secondary outcomes before and after the intervention in both groups was estimated using stata 14.0.based on data of a previous meta analysis, estimates of required sample size assumed a 20% reduction in the proportion of diarrhea. intra-cluster correlation coefficient (icc) was set low at 0.04 and the cluster sizes (number of subjects in a cluster, m) were expected to be 18. the sample size was multiplied by a design effect of 1.68, calculated using de=1+icc (m-1), to accommodate the clustering effect. the sample was further adjusted for a potential 20% loss to follow-up over one year, thus requiring a sample of 180 per group. therefore, the present study estimated that a total of 20 clusters inhabited by 358 households with child aged 6 to 59 months would have 80% power to detect the 20% reduction in the proportion in diarrhea at 5% level of significance.

Eligibility criteria:
inclusion criteria: * at least one child aged between 6 - 59 months * family planning to stay in their home for the next 12 months * written consent taken from the head of household exclusion criteria: * child had chronic diseases or severely malnourished. * family that might leave their house before one year. * household that the lord of house refuses to participate.
follow-up study for participants of jointstem investigator initiated trial by arthroscopy

Conditions: Degenerative Arthritis; Knee Arthritis

Summary: this clinical trial is conducted to assess the long-term safety of "jointstem" in patients with degenerative knee arthritis who participated in the previous bs-js-iit1 investigator initiated trial.

jointstem is injectables for an oa treatment that uses autologous adipose-derived mesenchymal stem cells. as it does not use allogenic tissues and is cultured without additional genetic modification, it is classified as 'autologous cell therapy' and is completely free of immunologic rejection. this clinical trial is planned to follow-up the long-term safety of "jointstem" in patients with degenerative knee arthritis who participated in the previous bs-js-iit1 investigator initiated trial. subjects who participate in the bs-js-iit1 study and agree to this extension test in writing will be assessed for safety by conducting laboratory tests, vital signs, physical examinations and adverse events every 12 months after visit 1. however, after unblinding of the bs-js-iit1 investigator initiated trial, subjects in the control group (placebo administration) will terminate the follow-up of this extended clinical trial and conduct routine treatment for degenerative knee arthritis at the discretion of the researcher. appropriate measures and follow-up observations shall be implemented for abnormal reactions occurred during this extended test period until they are terminated (such as the loss of the relevant adverse event or inability to conduct follow-up investigations).

Eligibility criteria:
inclusion criteria: * participants of jointstem iit by arthroscopy (bs-js-iit1) * participants who signed informed consent document of this study exclusion criteria: * no applicable

Keywords: stem cell adipose tissue derived mesenchymal stem cell osteoarthritis degenerative arthritis long term biostar rbio
lidocaine and ketamine versus standard care on acute and chronic pain

Conditions: Pain; Nausea

Summary: the investigators are conducting this study to find out if intravenous (injected through the vein) infusion of lidocaine and ketamine administered with general anesthesia is as effective as a paravertebral block in lessening pain after surgery and that both of these techniques are superior to general anesthesia alone in reducing pain immediately after surgery and in the long-term.

participants will be randomized into one of three study groups; group 1 - paravertebral group - ropivacaine is injected near the spine before surgery. midazolam and fentanyl are administered intravenously for sedation. group 2 - lidocaine/ketamine - general anesthesia with lidocaine and ketamine administered intravenously throughout your surgery and for 60 minutes after surgery. group 3 - general anesthesia alone. general anesthesia with placebo administered intravenously throughout surgery and for 60 minutes after surgery. all participants will rate their pain on a scale from 0 to 10 after surgery and on days 1 and 2 after surgery. participants are called 3 and 6 months after surgery for pain and quality of life assessments

Eligibility criteria:
inclusion criteria: * age greater than 18 and less than 75 years * male * unilateral inguinal hernia scheduled for elective open repair exclusion criteria: * incarcerated hernia or urgent procedure * reoperation (recurrent hernia) * contraindication to regional anesthesia such as: * coagulopathy * infection at the site of needle insertion * pre-existing chronic pain (at any site) requiring treatment * contraindication to any study medication (local anesthetic or ketamine) * history of significant axis i psychiatric disease (major depressive disorder,bipolar disorder, schizophrenia, etc.) * significant hepatic (alt or ast \> 2 times normal) or renal (serum creatinine \> 2 mg/dl) impairment

Keywords: inguinal herniorrhaphy pain assessment outcomes
the icalic international multicentric study

Conditions: Critical Illness

Summary: this study will evaluate the ease of use of the new calorimeter (q-nrg (cosmed, italy)) in intensive care unit (icu) patients compared to currently used calorimeters (i.e. quark rmr 1.0(cosmed, italy) or deltatrac metabolic monitor (datex, finland)), as well as the stability and the feasibility of the measurements in various clinically relevant situations. time needed to prepare and start indirect calorimetry (ic) measurement will be compared as the measure of the ease of use of the calorimeter.

background and aims: this study aims at evaluating the ease of use of the new calorimeter for the measurement of energy expenditure (ee) in intensive care unit (icu) patients. ee in icu patients is highly variable depending on the severity of the disease and treatments. clinicians need to measure ee by indirect calorimetry (ic) to optimize nutritional support for the better clinical outcome. however, indirect calorimeters available on the market have insufficient accuracy for clinical and research use. difficulties of handling and interpretation of results often limit ic in icu patients. an accurate, easy-to-use calorimeter has been developed to meet these needs. the study device: the new calorimeter (q-nrg, cosmed) is capable of ic measurements in mechanically ventilated patients without warm-up and limited calibration. the disposable in-line pneumotach flow meter and direct sampling of respiratory gas from the ventilator circuit enables the accurate measurement of oxygen consumption volume (vo2) and co2 production volume (vco2) to derive the energy expenditure. the software interface to manage the device and the collected data provides easy-to-use, user-friendly interface. q-nrg does not bear the european commission conformity mark (ce mark), but has been approved by the swiss authority for medical devices (swissmedic) for use in this study. q-nrg will be used in the way it is intended to be used as described in the instruction manual. currently used indirect calorimeters at each study center will be used as the comparator.

Eligibility criteria:
inclusion criteria: * mechanically ventilated adult icu patients exclusion criteria: * fraction of inhaled oxygen (fio2) \> 70% * positive end expiratory pressure (peep) \>10cmh2o * peak ventilatory pressure \> 30cmh2o * presence of air leaks from thoracic drain tube * changes in vasoactive agent dose (\>20%, \<1 hr before and/or during ic) * agitation or change in sedative dose (\>20%, \<1 hr before and/or during ic) * change in body temperature (\>0.5°c, \<1 hr before and/or during ic) * expected duration of icu stay \< 24 hours * expected survival of the patient \< 24 hours

Keywords: indirect calorimetry critical care mechanical ventilation energy expenditure icalic study