Kornimate/medical-research-clean huggingface dataset:
a feasibility study of adaptive intensity-modulated radiation therapy

Conditions: Head and Neck Cancer

Summary: patients with head and neck cancer and are schedule to receive standard radiation therapy known as imrt to treat cancer

in this study, we will plan additional measurements of the position of the patient's organs weekly during radiation treatment. we will analyze these measurements in order to evaluate whether we need to adjust our treatment procedures for the remainder of the treatments. we might adjust the dose of radiation received to specific organs in order to try to minimize the amount of radiation the healthy tissue receives.

Eligibility criteria:
inclusion criteria: * age \>= 18 * karnofsky performance status of \>= 60 * new diagnosis of head-and-neck cancer, all subsites included (i.e. nasopharynx, oropharynx, oral cavity, hypopharynx, larynx.) * all stages with measurable gross disease (\>= 1.0 cm) by ct imaging * pathologic confirmation of squamous cell carcinoma by biopsy or cytology * signed study-specific consent form * sequential or concurrent chemotherapy is allowed but not mandated. (no chemotherapy is allowed if patient is judged not to be a candidate for chemotherapy by the medical oncologist) exclusion criteria * age \< 18 * karnofsky performance status \< 60 * radiographic or pathologic evidence of distant metastatic disease (i.e. other than cervical lymph nodes) * prior radiation therapy to the head-and-neck region

Keywords: newly diagnosed head and neck cancer
ablation of anisochronous zones vs spatio-temporal dispersal zones with antral electrical isolation during radiofrequency treatment of paroxysmal or persistent atrial fibrillation

Conditions: Atrial Fibrillation

Summary: using isochronous maps during radiofrequency ablation procedures may identify the driver zones responsible for atrial fibrillation maintenance with greater accuracy compared to a conventional procedure (simple antral isolation of the associated pulmonary veins or, if necessary, combined with removal of spatio-temporal dispersal zones) that do not use isochronous maps, and thus improve the efficiency and safety of atrial fibrillation treatment by radiofrequency treatment.


Eligibility criteria:
inclusion criteria: * the patient must have given their free and informed consent and signed the consent form * the patient must be a member or beneficiary of a health insurance plan * the patient is at least 18 years old * the patient has paroxysmal or persistent atrial fibrillation * the patient is available for 18 month follow-up exclusion criteria: * the subject is participating in a category 1 interventional study, or is in a period of exclusion determined by a previous study * the subject refuses to sign the consent * it is impossible to give the subject informed information * the patient is under safeguard of justice or state guardianship * the patient is pregnant or breastfeeding * sinus rhythm has not been able to be determined using external electric cardioversion * patient not susceptible to atrial fibrillation following wide antrum circle ablation * the subject has already been included in the study (patients cannot be included more than once)
basic research study to examine the relation between muscle insulin resistance and lipid production in the liver.

Conditions: Insulin Resistance

Summary: the purpose of this study was to examine the pathophysiology of insulin resistance and the relation to the metabolic syndrome in humans.

in this study insulin resistant (ir), young offspring of parents with type 2 diabetes (18-46 years) and healthy, lean elderly individuals (65-90 years) underwent 1h/13c mrs measurements of liver and muscle lipid and glycogen content before and after a high carbohydrate meal challenge. hepatic de novo lipogenesis was determined as the incorporation of deuterium, from deuterium labeled water (2h2o), into plasma triglycerides 5. these metabolic studies were performed in 2 sets: study part 1: resting, study part 2: after 1 bout of 45 minutes exercise. the study has been completed and published as two papers: august 16, 2011 and july 24, 2012.

Eligibility criteria:
inclusion criteria: * body mass index \< 29 kg/m2 * no regular exercise routine * non-smokers * absence of systemic and organ disease. exclusion criteria: * hematocrit \< 35 vol% * history of claustrophobia * ferromagnetic implants * regular exercise regimen * not weight stable * any significant hematological, neurological, musculoskeletal or endocrine disease (including diabetes mellitus) * any significant cardiovascular condition, including confirmed cad and prior cardiovascular events * taking coumadin as anticoagulant therapy.

Keywords: insulin resistance exercise de novo lipogenesis nafld magnetic resonance spectroscopy
regenerative peripheral nerve interface for prophylaxis against post-breast surgery pain syndrome

Conditions: Post-mastectomy Pain Syndrome

Summary: regenerative peripheral nerve interface (rpni) was first developed in 2012 by dr. paul cederna at the university of michigan as a means for amputees to control their prothesis with their minds. in the decade that followed, it was found rpni surgery not only provided amputees with neuroma (a growth made up nerve tissue) pain relief but could help prevent neuroma from developing as well. this single center, randomized controlled, investigator-initiated study will look at whether the rpni, a nerve burying procedure involving protecting sensory nerves with a small piece of the patient's pectoralis muscle, performed at the time of the standard mastectomy with immediate breast reconstruction surgery can prevent and/or reduce the risk for long-term nerve pain after breast cancer surgery (also called neuroma-related post-breast surgery pain syndrome (pbsps)) versus the standard surgery alone (control group). symptoms of pbsps include discomfort, numbness, tingling, and shooting pain in the chest and breast area. it is relatively common and may have many causes. about 200 adult females (18-65 years old) who are scheduled to undergo mastectomy with immediate breast reconstruction surgery will be approached for this study. those who agree and sign the informed consent form will be randomized in 1:1 fashion (50/50 chance) to either the rpni group or the no rpni (control) group. study participants will complete self-reported surveys (pre-surgery and at months 1, 3, 6, and 12 post-surgery) designed to measure pain levels, quality of life, and function before and after surgery. study participation will last approximately 12 months. subjects will remain blinded to their assigned study arm until their study participation has concluded.


Eligibility criteria:
inclusion criteria: 1. adult female 18 to 65 years of age. 2. undergoing breast mastectomy with immediate reconstruction. 3. able to provide informed consent and comply with study procedures. exclusion criteria: 1. history of chronic pain syndrome unrelated to breast surgery. 2. unwillingness or inability to comply with the study's follow-up requirements. 3. cognitive impairment or language barriers preventing proper understanding of study procedures and assessments. 4. participation in other interventional trials or treatments aimed at pain management that could confound study outcomes as determined by the pi. 5. other medical or surgical contraindication to the involved procedure (rpni) as determined by the pi.
focus thoracic ultrasound for dyspnea diagnosis in elderly patient in the emergency department

Conditions: Dyspnea

Summary: brief summary: the aim of this study is to analyze in elderly patients with undifferentiated dyspnea, the concordance of diagnosis before and after a focus thoracic ultrasound in comparison with the reference one established by an adjudication committee

dyspnea is associated with a variety of etiology whose diagnosis is challenging especially in elderly patients with unconventional symptoms. focus thoracic ultrasound is composed by an advanced cardiac ultrasound with doppler measures and a lung ultrasound. it has already demonstrated its ability to reduce diagnosis uncertainty in emergency patients with dyspnea. however, adequacy of diagnosis before and after thoracic ultrasound has not been investigated in such patients. in this population, after clinical examination and use of any resource deemed necessary, the physician states its hypothesis in closed list. an emergency physician then realizes a thoracic ultrasound exam. an adjudication committee with all the patient's file will state the reference hypothesis.

Eligibility criteria:
inclusion criteria: * acute onset dyspnea in patient over 74 years old consulting at the emergency department exclusion criteria: * need for icu * need for a mechanical ventilation * less than 24 hours hospital stay * inability to consent
an observational post authorisation study to evaluate safety and efficacy in patients receiving azacitidine in daily clinical practice in the netherlands

Conditions: Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute

Summary: the study design is a prospective, non-interventional, observational single arm study. a minimum of 150 patients will be recruited from approximately 30 haematology/oncology sites in the netherlands. in all cases, the decision to treat the patient with azacitidine was already made prior to the decision to enter the subject into the study. recruitment will continue until end of june 2015, provided a minimum of 150 patients have been included in the study. when this date is reached, all patients on azacitidine will continue to be followed until the last patient enrolled has been followed for 12 months.


Eligibility criteria:
inclusion criteria: * patients over 18 years of age who understand and voluntarily sign an informed consent form. * patients who are treated with azacitidine in accordance with registered indication and clinical practice. exclusion criteria: * refusal to participate in the study. * participation in an interventional clinical study. * patients previously treated with azacitidine except when given as induction therapy for a maximum of three courses. * women who are pregnant or breast-feeding. * hypersensitivity to the active substance or to any of the excipients. * advanced malignant hepatic tumors.

Keywords: leukemia chronic acute observational non-interventional ocean netherlands azacitidine
effects of open and closed system suctioning on suctioning frequency and amount of secretion

Conditions: Secretion; Excess, Salivation

Summary: tracheal suctioning is a process which is often applied to patients' care who have an artificial airway and whose respiration is achieved via mechanical ventilation. when secretions are not cleaned enough, it causes a variety of complications in the patient from hypoxemia to infection. it is reported that the studies with nurses in clinical practice have shown that they have opinions such as the closed system does not suction the patients effectively as the open system does; it remains incapable in removing secretions, thus the suctioning process is being applied more frequently. therefore this study is designed to examine the amount of secretions and frequency of suctioning as a result of open and closed suctioning systems.

patients will be monitored for two days. on the first day, the patient will be followed up with an open system and the second day closed suctioning system will be used, or the patient will be followed up with a closed system on the first day and followed with an open system on the second day. the patients are randomly allocated on the first follow up days. the follow-up period has two consecutive days. suctioning will be performed for 12 hours in one day. the number of suctions will be recorded. the amount of secretion will be accumulated in the mucus collection vessel. at the end of the day, the secretion will be weighed with precision weighing.

Eligibility criteria:
inclusion criteria: * orally intubated in first 96 hours * stabilized patients in conditionally * platelets \> 50.000 * not have hemorrhagic secretions exclusion criteria: * hemodynamically unstabilized patients

Keywords: intensive care unit endotracheal suctioning open suctioning system closed suctioning system nursing
clinical and electrographic changes in responsive neurostimulation system (rns) patients with acupuncture treatment

Conditions: Epilepsy

Summary: the purpose of this study is to determine effects of acupuncture on a patient's mood and cognition,evaluate changes in clinically-reported seizure frequency and severity and analyze effects of acupuncture on electrographic epileptiform activity stored by the rns system


Eligibility criteria:
inclusion criteria: * patient implanted with the rns system * patient can undergo 12 weeks of acupuncture * patient is able remain on stable medications for 12 weeks * patient is able to remain on stable detection and stimulation settings for 12 weeks * patient or/and caregiver is able to understand and sign informed consent and hipaa authorization * patient or caregiver able to maintain a seizure diary for duration of study exclusion criteria: * patient and /or caregiver is unable to sign informed consent to study * patient has a bleeding disorder, pacemaker, or pregnant

Keywords: acupuncture rns seizure
online surveillance of treatment of children with growth hormone deficiency with zomacton

Conditions: Growth Hormone Deficiency

Summary: the purpose of this study is to investigate long-term treatment with zomacton® for pituitary short stature in children with insufficient growth hormone production and/or short stature caused by turner syndrome.


Eligibility criteria:
inclusion criteria: * therapeutic need according to spc * written informed consent exclusion criteria: * contraindications according to spc
tailoring mindfulness interventions for families managing chronic health conditions

Conditions: Mindfulness; Chronic Disease

Summary: this is not an intervention or treatment study. it is an observational qualitative data study about tailoring a mindfulness intervention to assist families managing chronic health conditions.

this is not an intervention or treatment study. it is an observational qualitative data study. collecting information from virtual audio only interviews from between 30 and 40 us adults about whether a mindfulness intervention would assist families managing chronic health conditions; and if so, how should it be tailored to meet their needs.

Eligibility criteria:
inclusion criteria: * english speaking and either a long-time mindfulness practitioner/instructor or an adult managing a chronic health condition for yourself or a close family member exclusion criteria: * unable to complete an audio interview in english lasting 30-60 minutes
microfluidic device to diagnose leptomeningeal metastasis in breast cancer

Conditions: Breast Cancer; Leptomeningeal Metastasis

Summary: this study will prospectively enroll 36 evaluable subjects with breast cancer who are undergoing workup for clinical suspicion of leptomeningeal metastasis (lm). neuroimaging consisting of mri of the brain or total spine (or both, as clinically indicated) will be obtained in all patients. patients will also undergo a lumbar puncture and standard csf evaluation, which may consist of intracranial pressure measurement, csf protein, glucose, white and red cell analysis, infectious cultures, as well as conventional cytopathologic analysis (cytocentrifuge). an additional csf sample will be obtained for evaluation of csf ctcs by oncoceetm technology and cell-free dna (recommended amount: 1 tube, 10 ml) at the time of lumbar puncture.

leptomeningeal metastasis (lm) is a condition in which cancer cells seed the meninges and may go on to invade the brain parenchyma, spinal cord, cranial nerves or peripheral nerves. it is a devastating complication of breast cancer, and is often considered in the differential diagnosis when patients with breast cancer present with new neurologic symptoms. it was previously thought to be a rare occurrence, but autopsy series have shown the true overall incidence to be up to 8%. in fact, while the incidence of meningeal metastasis from other malignancies has decreased, the opposite is true of breast cancer, in which clinical evidence suggests an increasing incidence.

Eligibility criteria:
inclusion criteria: * adult (18 years or older) patients, with invasive breast cancer, of all racial and ethnic origins * undergoing lumbar puncture for clinical or radiographic suspicion of leptomeningeal metastasis * provide study-specific informed consent * patients with unequivocal or suspicious mri findings. * of those with a definitive diagnosis of lm (i.e. positive csf cytology), 10 evaluable patients will be accrued. exclusion criteria: * prior csf fluid which identified malignant cells after 10 evaluable patients with positive csf are accrued.

Keywords: breast carcinoma breast tumors cancer of the breast malignant tumor of the breast breast cancer leptomeningeal metastasis
preliminary study of the quality of the oral flora in parkinson's patients

Conditions: Oral Health; Parkinson Disease

Summary: this is a prospective interventional clinical study whose main objective is to determine the impact of oral hygiene guidance on the oral health status of patients with parkinson disease

caries and periodontitis are infectious diseases that can eventually lead to the loss of the dental organ. the masticatory deficit engendered will have repercussions on the general state of the subject and on his quality of life (pains, difficulties of feeding which can cause nutritional deficiencies ...). the systematic review of the literature, despite low levels of evidence, shows that there is an influence of parkinson's disease on oral health. our goal is therefore to determine the impact of implementing appropriate oral hygiene measures on improving the quality of life of patients with parkinson's disease. this is a 40-patient, interventional, preliminary study that will rely on indicators of oral health status (dmf, periodontal index, presence of pathogenic bacteria), as well as a questionnaire measuring impact of oral conditions on patient well-being (ohip-14). these data will be collected before and after the implementation of the hygiene measures, within a period of 6 months.

Eligibility criteria:
inclusion criteria: * major patient * patient with parkinson disease * able to give written informed consent * affiliated to french health care system exclusion criteria: * patient under tutorship and curatorship * pregnant women * patient wearing subtotal or total dental prosthesis * antibiotic treatment or antiseptic mouthwashes in the month prior to sampling * patient with less than 6 teeth distributed on maxilla and mandible

Keywords: oral health parkinson disease tooth cavities saliva mucosa
quality of life in kidney stone patients undergoing surgery

Conditions: Kidney Calculi; Quality of Life

Summary: this is a prospective randomized study, comparing quality of life in renal stone patients undergoing surgical treatment with ureteroscopy (urs) versus percutaneous nephrolithotomy (pnl).

in united states, the prevalence of renal stone is 8.8% with slight predomination in male than female. they can be symptomatic marked by symptoms of flank pain, hematuria or urinary tract infection, or completely asymptomatic and incidentally discovered. three modalities are accepted as treatment options for renal stone, including shockwave lithotripsy (swl), percutaneous nephrolithotomy (pnl) and ureteroscopy (urs). while some standard guidelines were proposed for appropriate treatment selection with regard to stone size, no recommendations or guidelines exist for the surgical management of 1-2 cm renal stones. both pnl and urs are equally accepted as treatment options for stones at this size. the selection of either procedure currently is left to the treating surgeon can be influenced by anatomical or stone factors as well as patient preference. for urs, frequent requirement for postoperative ureteral stents may result in significant morbidity and a detriment to quality of life owing to irritating bladder symptoms caused by the stent itself. pnl rarely requires postoperative ureteral stent but it may bring longer operative time and hospitalization. pnl therefore may be a treatment option that preserves quality of life compared to urs for patients presenting with the 1-2 cm sized kidney or ureteral stone. one reasonable way to evaluate efficacy of treatment options is to assess patient's quality of life resultant from the selected modality. quality of life for renal stone formers is an important but under-studied facet of nephrolithiasis management that should be incorporated into clinical decision making. the short form-36 health survey questionnaire (sf-36) is a patient-reported survey of health status. it has been validated and is commonly used to determine the efficacy of a given health treatment in many settings, including urologic intervention. the ureteral stent symptom questionnaire (ussq) is a validated and widely accepted instrument to evaluate the impact of ureteral stents on quality of life. the investigators plan to use these two questionnaires as a standard outcome measurement to compare impact on quality of life in patients randomized to undergo two different modalities (pnl versus urs) of stone treatment.

Eligibility criteria:
inclusion criteria: * patient with a renal or proximal ureteral stone measuring 1-2 cm in size on preoperative ultrasound, computed tomography, or plain radiographic imaging exclusion criteria: * serious illness likely to cause death within the next 5 years, so as to exclude significant metabolic derangements that might lead to adverse surgical outcome. * stones with measured size larger than 2 cm or smaller than 1 cm. * patients with ureteral or renal anatomy or stones located in a position judged to be unsafe for randomization. * pregnancy.
an eight-week study of saredutant and paroxetine as combination treatment for major depressive disorder

Conditions: Depressive Disorder, Major

Summary: the main purpose of this study is to evaluate the efficacy of saredutant 100mg or 30mg once daily in combination with paroxetine 20mg once daily compared to saredutant placebo in combination with paroxetine 20mg once daily in patients with major depressive disorder. the study also includes a double-placebo group (saredutant placebo in combination with paroxetine placebo).


Eligibility criteria:
inclusion criteria: * outpatients with recurrent major depressive disorder exclusion criteria: * symptoms of current depressive episode for less than 30 days or more than 2 years * mild depression, as measured by standard clinical research scales * significant suicide risk * lack of sexual activity (including masturbation) * other psychiatric conditions that would obscure the results of the study * history of failure to respond to antidepressant treatment * pregnancy or breast-feeding

Keywords: major depressive disorder depression major depressive episode antidepressant