Kornimate/medical-research-clean huggingface dataset:
effect of electrical stimulation at acupoints on blood pressure

Conditions: Hypertension

Summary: to determine if electrical stimulation on acupoints has any effect on hypertensive subjects.

all subjects will be assigned into control and experimental groups by a random table. the first 40 numbers in the first row will be used for the study. subjects assigned with an odd number will be divided into the control group. role of subjects subjects in the experimental will receive hans treatment for hypertension. no invasive procedures will be used for subjects in either the control and experimental groups. this randomized controlled study will recruit hypertensive subjects into control and experimental groups using a random table. only the subjects in the experimental group use hans stimulation as a treatment for high blood pressure. the treatment regiment is discussed in the treatment section in detail. the subjects in the control group will not

Eligibility criteria:
inclusion criteria: * diagnosis of mild hypertension (160-140/100-90 mmhg), male and female subjects with any racial background will be invited to participate in the study. * all adult age groups are included in the study. * subjects must sign an informed consent form. exclusion criteria: * diagnosis of severe hypertension (200-161/120-101 mmhg), limited physical activity, heart failure, kidney diseases and mental diseases are excluded in the study. a questionnaire will be used in the initial patient screening.

Keywords: hypertension hans electrical stimulation
efficacy of game-based emg-biofeedback therapy in post-stroke dysphagia

Conditions: Stroke; Dysphagia; Surface Electromyography; Biofeedback; Swallowing Disorder

Summary: this study aims to determine the effectiveness of game-based biofeedback application via surface electromyography in patients with post-stroke dysphagia. the same treatment interventions will be applied with and without biofeedback, and thus the contribution of adding biofeedback to the treatment will be determined.


Eligibility criteria:
inclusion criteria: 1. history of hemorrhagic or ischemic stroke longer than 3 months 2. being over the age of eighteen 3. level ≤ 6 on the functional oral intake scale (fois) 4. post-stroke onset of swallowing complaints 5. ability to communicate with the patient and carry out the given commands 6. mini mental test evaluation ≥ 24 points 7. absence of concomitant serious systemic disease (unregulated hypertension, decompensated heart failure, malignancy, infection, pacemaker, epilepsy, etc.) 8. detection of pathology in the oropharyngeal phase of swallowing in videofluoroscopic evaluation 9. not taking any swallowing-related treatment in the last 3 months exclusion criteria: 1. history of neoplastic disease and/or radiotherapy to the head and neck region 2. having additional musculoskeletal disease or non-stroke neurologic disease that may cause swallowing disorders 3. unable to communicate or carry out commands 4. inability to maintain head-holding balance 5. patients with severe pathology in bolus formation or delivery of the bolus to the pharynx during the oral swallowing phase
esophageal manometry in mechanically ventilated patients

Conditions: Acute Respiratory Failure

Summary: esophageal pressure measurements are used in to determine chest wall elastance and calculate lung elastance and transpulmonary pressure in mechanically ventilated patients. a dedicated esophageal balloon catheter is then placed in the esophagus to measure tidal variations in esophageal pressure. in this study high resolution solid-state manometry technique was used to provide detailed and continuous measurements of esophageal pressures in the different parts of the esophagus. measurements were performed during ongoing mechanical ventilation at different levels of endexpiratory pressure.

esophageal pressure measurements are used in to determine chest wall elastance and calculate lung elastance and transpulmonary pressure in mechanically ventilated patients. a dedicated esophageal balloon catheter is then placed in the esophagus to measure tidal variations in esophageal pressure. in this study high resolution solid-state manometry technique was instead used to provide detailed and continuous measurements of esophageal pressures in the different parts of the esophagus. the manometry catheter has 36 circumferential sensors at 1 cm intervals. each sensor has 12 pressure-sensitive segments that add to the signal at that location. measurements were performed during ongoing mechanical ventilation at different levels of endexpiratory pressure. possible differences in tidal variations in esophageal pressure in different parts of the esophagus were assessed.

Eligibility criteria:
inclusion criteria: * patients in the critical care unit receiving mechanical ventilation or patients anesthetized and undergoing surgery exclusion criteria: * patients with a contraindication to insert a catheter in the esophagus for instance due to an operation.

Keywords: esophageal pressure chest wall elastance lung elastance transpulmonary pressure
cetuximab, 5-fu and radiation as neoadjuvant therapy for patients with locally advanced rectal cancer

Conditions: Rectal Cancer

Summary: the standard treatment for rectal cancer is to receive the chemotherapeutic drug 5-fluorouracil (5-fu) with radiation therapy before having surgery to remove the rectal cancer. this is known as neoadjuvant chemoradiotherapy. the purpose of this research study is to determine if cetuximab improves the benefits of neoadjuvant chemoradiotherapy when given with 5-fu and radiation therapy.

the epidermal growth factor receptor (egfr) present in normal and tumor cells is involved in signaling pathways affecting cellular growth, differentiation, proliferation and programmed cell death. overexpression of egfr has been associated with poorer prognosis in colorectal cancer. cetuximab targets and blocks egfr and has been shown to be safe and effective in treating colorectal cancer and head and neck cancers. the primary hypothesis is that cetuximab in combination with standard 5-fu and radiation as neoadjuvant therapy would improve pathological complete response (pcr) compared to the historical rate (30% versus 10%). the regimen would be considered promising if 5 or more of 25 evaluable participants achieve pcr. the probability of observing this outcome is 0.91 and 0.10 if the true pcr rate is 30% and 10%, respectively.

Eligibility criteria:
inclusion criteria: * histologically confirmed adenocarcinoma of the rectum that begins within 15cm of the anal verge as determined by sigmoidoscopy and/or colonoscopy, with no evidence of distant metastatic disease. a complete colonoscopy to the cecum is recommended prior to initiating protocol therapy. * staging with transrectal ultrasound or endorectal coil magnetic resonance imaging (mri) to confirm clinical stage of t3 or t4 or lymph node positive rectal adenocarcinoma * tumor is k-ras wildtype by method of choice at respective institution (testing codons 12 and 13) * performance status: eastern cooperative oncology group performance score (ecog ps) less than or equal to 2 * 18 years of age or older * no evidence of metastatic disease by abdominal/pelvic (computed tomography) ct and chest imaging * adequate bone marrow, renal,and hepatic function as outlined in protocol * all patients will be evaluated by a surgeon and considered a candidate for definitive surgery * coumadin or heparin management for line care of other indications is permitted. the international normalised ratio (inr) will be monitored weekly in patients taking coumadin. exclusion criteria: * prior treatment for this malignancy * prior history of pelvic radiation therapy * prior history of 5-fu based or egfr receptor inhibitor therapy * prior history of an allergic reaction to a monoclonal antibody * uncontrolled serious medical or psychiatric illness * significant history of uncontrolled cardiac disease * sexually active women of childbearing potential must use an effective method of birth control during the course of the study * unwilling to agree to pre and post-cetuximab sigmoidoscopy and biopsy

Keywords: 5-fu cetuximab radiation adenocarcinoma of the rectum neoadjuvant therapy
bone changes assessment in screw-retained maxillary complete denture with electric welded framework versus cast one

Conditions: Bone Resorption

Summary: comparing bony changes around implants that will be joined by ametal framework either with electric weiling or with the conventional casting metal

joining multiple implants together in the edentulous arches is considered agood solution, using the conventional casting technique has many disadvantages due to lab errors and time and cost consuming on ,the other hand the study aims to owercome these disadvantages using electric welding metal framework.

Eligibility criteria:
inclusion criteria: * age range from 30 to 65 years old. * absence of any medical disorder that could complicate the surgical phase or affect osseointegration. * the patients must be completely edentulous. * the patient must have enough bone height for implants minimum length of 10mm and a minimum diameter of 5 mm. * patients with good oral hygiene. * complete denture wearer. * adequate inter arch space for screw retained prosthesis. * absence of any intra-oral pathological condition. exclusion criteria: patients with recent extraction(less than three months). * patients with inflamed ridge or candida infection. * patients with flappyridge. * parafunctional habits.
rapid sequence intubation and hemodynamic disorders in the operating room: a prospective multicenter observational study

Conditions: Rapid Sequence Intubation

Summary: there is a great heterogeneity in the practice of rapid sequence induction in the operating room in the world. there are no recent data assessing the rate of implementation of the latest french formalized expert recommendations in clinical practice. in addition, the modalities for the management of haemodynamic disorders, particularly hypotensive disorders, during rapid sequence induction are not described in these recommendations, although these are frequent events with a non-zero morbidity mortality potential. the goal of this prospective, observational, multicenter, anesthetic study is to describe the clinical practice of french anesthesiologists regarding the prevention of severe hemodynamic disorders during rapid sequence anesthetic induction in adult patients. the primary outcome measure is the occurrence of a major haemodynamic disorder defined by a mbp ≤ 50 mmhg (or ≤ 40% of the reference value) and/or ≥ 110 mmhg and/or the occurrence of sustained arrhythmia not present at induction and/or cardiac arrest within the first 10 minutes after induction of anesthesia. the clinical practices of pre-oxygenation, induction and intubation of french anesthesiologists and compliance with the formalized expert recommendations of 2017 and 2018 will also be studied secondarily. the elements for the prevention of gastric fluid inhalation, the organization and equipment used, the anesthetic and non-anesthetic drugs used, the clinical and paraclinical neurological and cardio-respiratory parameters and the nature of the complications following anaesthetic induction will be collected up to the 10th post-induction minute.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years' old * procedure requiring general anesthesia with oro or nasotracheal intubation * anesthetic management with indication of rapid sequence induction * no objection after oral and written information to the patient exclusion criteria: * age \< 18 years' old * impossible intubation planned * preoperative respiratory distress (spo2 \< 90% in ambient air) * preoperative shock (mbp≤ 65 mmhg or vasopressive amines) * preoperative coma defined by a glasgow score ≤ 12/15 * patient in cardiopulmonary arrest * patients under guardianship or curatorship

Keywords: anesthetic induction adult patients hemodynamic disorders arrythmia cardiac arrest pre-oxygenation mean blood pressure
drug interaction study between antimalarial and anti-hiv medications

Conditions: HIV Infections; Malaria

Summary: the purpose of this study is to find out whether taking certain anti-hiv medicines with certain antimalarial medicines affects the amount of the medicines in the blood. the study medicines that will be used are artemether/lumefantrine (antimalarial medication) and lopinavir/ritonavir or efavirenz (anti-hiv medications). artemether/lumefantrine is not approved by the united states food and drug administration (fda) but is recommended as standard of care medical treatment for malaria in africa and asia. lopinavir/ritonavir and efavirenz are approved by the fda. artemether/lumefantrine and lopinavir/ritonavir or efavirenz may need to be used together to treat children in africa and asia. we seek to learn about whether or not the use of these medicines together results in a change in blood levels of any of these medicines. the information obtained from this study will help doctors to provide a better treatment to children and adults with malaria and hiv.

the study involves 5 non-consecutive overnight stays and 14 additional outpatient visits at the san francisco general hospital research center.

Eligibility criteria:
inclusion criteria: * absence of hiv infection prior to study entry * within 20% (+/-) of ideal body weight and must weigh at least 50kg * healthy subjects without evidence of acute or chronic illnesses, including diabetes, high blood pressure, coronary artery disease, psychiatric illnesses, liver or kidney impairment exclusion criteria: * use of illicit drugs or alcohol that could interfere with the completion of the study. * use of any over- the- counter or prescribed drugs unless approved by the principal investigator or study physician. * pregnant or breast- feeding. * history of acute or chronic illnesses, such as diabetes, high blood pressure, coronary artery disease, psychiatric illnesses, liver or kidney impairment. * evidence of acute illness. * family history of congenital prolongation of qtc interval or with any conditions known to prolong qtc interval, such as cardiac arrhythmias, bradycardia or severe heart disease * history of electrolyte abnormalities.

Keywords: healthy controls research clinical study pharmacokinetic pk hiv malaria
treatment of adolescent suicide attempters (tasa)

Conditions: Depression; Suicide, Attempted

Summary: the purpose of this study is to compare the effects of three types of treatments for depressed teenagers who have attempted suicide.

suicide is the third leading cause of death in adolescents and is a major public health problem. depression is the most common diagnosis for adolescent suicide attempts. little is known about what treatment is best for these adolescents since they are usually excluded from participation in research studies. participants in this study will be randomly assigned to receive carefully monitored antidepressant medication with routine support and management, cognitive behavioral therapy (cbt), or a combination of antidepressant medication plus cbt.

Eligibility criteria:
inclusion criteria: * at least one suicide attempt or interrupted attempt within the past 45 days * continuously reside with a primary caretaker (parent, legal guardian, foster parent) for at least 6 months that can provide legal consent

Keywords: dysthymic disorder adolescent
sensory room at an acute psychiatric unit

Conditions: Psychiatric Disorder

Summary: the aim of the presented study is to explore the effectiveness of a sensory room in reducing seclusion, restraint and aggression at an acute psychiatric ward.

background in recent years, there has been an increase in violence in mental health centers in israel. until recently, the phenomenon was treated under mechanical restrictions and patient isolation. today the trend is to reduce the use of restrictions, with the main alternative being the provision of medication and de-escalation techniques, one of which is sensory stimulation using sensory rooms. a sensory room in the psychiatric unit has been found as an effective intervention for reducing patients' distress and aggression. however, the effectiveness of using the room has not yet been studied in israel and in relation to pain. method the experimental study will be conducted in two phases each lasting three months in an acute psychiatric ward: 1. without intervention (control group). 2. with intervention. data on restrictions and aggression events will be collected throughout the two phases, and the participants will undergo an evaluation process using self reports. in addition,subjects who will participate in the intervention (study group) will wear an empatica-e4 wristband to monitor autonomous metrics during their stay in the sensory stimulation room and will undergo a brief interview regarding their experience using the room.thus the intervention phase (study group) will comprise mixed methods. population eighty men aged 18-50, a convenience sample, who speaks hebrew; treated with psychiatric medication for at least two weeks; and hospitalized for up to 70 days. expected results: statistical significant group differences will be found in the sum of ward restrictions (i.e., sedatives, physical restraint, and seclusion), showing less during phase 2 (study group): the study group (2nd phase) will receive fewer sedatives and use less physical restraint and seclusion. statistical significant group differences will be found in the aggression incidents showing fewer reports of aggression in the study group. statistical significant differences will be found in the hrv indices between pre and post sensory room treatment, showing reduced values post treatment. statistically significant correlations will be found between sensory over-responsivity and the number of aggression events so that higher sensory responsiveness (sor) will be correlated with more aggression events. statistically significant correlations will be found between sensitivity to pain and the number of aggression incidents: higher pain sensitivity will be correlated with fewer incidents of aggression.

Eligibility criteria:
inclusion criteria: * hebrew language proficiency receiving psychiatric medication of any kind regularly for at least 14 days hospitalized in full hospitalization for up to 70 days. exclusion criteria: * chronic pain, neurodevelopmental syndrome active use of psychoactive substances.

Keywords: psychiatric disorder sensory processing sensory room seclusion restraint aggression acute psychiatric ward
brain mechanisms of juvenile fibromyalgia

Conditions: Fibromyalgia

Summary: this study evaluates whether differences exist between adolescent females with juvenile-onset fibromyalgia and healthy controls in processing of pain and emotion at the neural level as assessed by functional magnetic resonance imaging (fmri). the study includes a longitudinal component to evaluate changes in neural processing of pain and emotion before and after different treatment strategies.

juvenile-onset fibromyalgia (jfm) is a chronic, widespread pain condition that primarily affects females. previous work has shown increased sensitivity to painful and non-painful sensory stimuli in adults with fibromyalgia, as well as brain processing abnormalities associated with these stimuli. these abnormalities in adults are highly predictive of fibromyalgia status (as opposed to healthy status) in adults. although jfm has some similar symptoms and features to fibromyalgia in adults, the neural mechanisms of jfm may be partially different, given the moment of sharp brain development characterising jfm. fmri scans will be completed before and after different treatments for jfm (e.g. neuromuscular training + cognitive behavioral therapy, graded aerobic exercise) to investigate the effects of treatment on brain measures related to pain, fatigue and emotion processing.

Eligibility criteria:
inclusion criteria: * diagnosis of juvenile fibromyalgia (by a pediatric rheumatologist or pain physician using 2010 american college of rheumatology criteria) * right handed * functional disability index score ≥ 7, indicating at least mild disability * stable medication regimen for 3 weeks prior to mri scan exclusion criteria: * non-mri compatible metal objects in the body (including braces, permanent upper retainers) * comorbid rheumatic disease (e.g. juvenile arthritis, systemic lupus erythematosus) * major psychiatric diagnoses (e.g. bipolar disorder, obsessive compulsive disorder, schizophrenia) or documented developmental delay * taking opioid pain medication

Keywords: fibromyalgia pain neuroimaging sensory sensitivity fatigue
the antibacterial effect of zinc ,silver and fluoride

Conditions: Dental Caries

Summary: natural teeth will be filled with the 3 different material then the dentin sample will be collected ,bacterial culture and elementary analysis will be done

orthodontic patient with premolar indicated for extraction , teeth will restored with the different material 3 months before doing extraction

Eligibility criteria:
inclusion criteria: * patient need teeth extraction for orthodontic treatment exclusion criteria: * carious teeth deciduous teeth
welchol® and sulfonylurea in treating patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the purpose of the study is to see how safe and effective and tolerable the use of colesevelam hydrochloride is for type 2 diabetes when added to sulfonylurea alone or in combination with other anti-diabetic drugs.


Eligibility criteria:
inclusion criteria: * age 18-75 years, inclusive * diagnosed with type 2 diabetes * stable dose of sulfonylurea alone or in combination with other anti-diabetic medications for 90 days * hemoglobin a1c value 7.5% to 9.5%, inclusive * c peptide \> 0.5 ng/ml * prescribed ada diet exclusion criteria: * history of type 1 diabetes or ketoacidosis * history of pancreatitis * uncontrolled hypertension * allergy or toxic response to colesevelam or any of its components * serum ldl-c \< 60 mg/dl * serum tg \> 500 mg/dl * body mass index (bmi) \> 45 kg/m2

Keywords: diabetes mellitus
use of continence care protocol in uk nursing homes.

Conditions: Urinary Incontinence Due to Cognitive Impairment; Urinary Incontinence

Summary: this is a retrospective cohort study. in the investigation the clinical use of the skin and leakage protocol (slep) is to be investigated. the slep is a generic digital diary form filled out to give information about the current status of continence care among care home residents. the slep tracks the number of leakage occurrences and daily skin health over a period of time with the purpose of assisting care staff in making decisions regarding continence care. the slep has been introduced at several united kingdom national health service care homes and with this investigation the investigators want to retrospectively analyse the data to determine the clinical usefulness of the form. the primary objective of the study is to describe any changes in product leakage rate at the baseline and follow up time period.


Eligibility criteria:
inclusion criteria: * subject is diagnosed with urinary incontinence managed with an absorbing incontinence product. * the skin and leakage protocol have been used in the care of the subject and there is data from at least two measurements. * subject is cared for in a residential care home using the skin and leakage protocol. * subject is over 18 years of age. exclusion criteria: * subject is not using an absorbing incontinence product to manage incontinence.
busulfan and fludarabine as conditioning for allogeneic stem cell transplantation: a pharmacokinetic study

Conditions: Hematologic Malignancy

Summary: a study of pharmacokinetics of daily intravenous busulfan

a study of pharmacokinetics of daily intravenous busulfan

Eligibility criteria:
inclusion criteria: * patients undergoing transplantation exclusion criteria: -

Keywords: pharmacokinetics transplantation busulfan