Kornimate/medical-research-clean huggingface dataset:
electro-acupuncture for central obesity

Conditions: Central Obesity

Summary: in this study, a 8-week, single blinded, randomized controlled clinical trial will be conducted to examine the efficacy and safety of body acupuncture in the treatment of central obesity in hong kong.

this is a pilot single-blind, randomized, sham-controlled trial. 168 central obesity patients will be randomly assigned to acupuncture group or control group. the duration of the treatment will be 8 weeks with 2 session per week and the follow-up period will be 2 weeks.

Eligibility criteria:
inclusion criteria: patients who meet all of the following criteria are defined as eligible participants: men and women aged between 18 and 65 years old; bmi ≥ 25 kg/m2; central obesity, defined as wc of ≥ 90 cm in men and ≥ 80 cm in non-pregnant women according to icd-10 \[24\]; not receiving any other weight control measures or any medical and/or drug history in last 3months. exclusion criteria: patients who meet any of the following criteria should be excluded from the study: endocrine diseases, including thyroid disorder, pituitary disorder, sex gland disorder, etc.; heart diseases, including arrhythmia, heart failure, myocardial infarction, patients with pacemaker; allergy and immunology diseases; bleeding tendency; pregnant or lactating women; impaired hepatic or renal function; stroke or unable to exercise.
rehabilitation exercise using digital healthcare system in patients with total knee arthroplasty

Conditions: Osteo Arthritis Knee

Summary: the study aims to examine the effect of short-term rehabilitation exercise support using digital healthcare system (uincare homeplus) in the patients with total knee arthroplasty. the study is a two-arm prospective randomized controlled study comparing the effect of rehabilitation exercise digital healthcare system at home with conventional brochure-based home exercise. gait speed (4-meter), pain (using numerical rating scale), knee joint range of motion (rom), lower extremities motor power (using manual muscle test), western ontario and mcmaster universities osteoarthritis index (womac), berg balance scale (bbs) and quality of life using eq-5d-5l will be evaluation on enrollment, 3-weeks, 6-weeks, 12-weeks and 24-weeks after enrollment.

total knee arthroplasty is treatment of choice for knee degenerative arthritis patients who are unresponsive to non-operative management including medications and physical therapies. total knee arthroplasty is an effective treatment enhancing the joint range of motion as well as reducing pain and correcting deformities which leads to better patient function with better quality of life. current method of post-operative rehabilitation is home-based self rehabilitation using brochure, combined with one or two times of education at the hospital before discharge. patients often find difficulty in doing rehabilitation by themselves at home without supervision which resulted in decreased compliance. with development of technologies using multi-motion sensor and ar(augmented-reality) system, the investigators have developed a digital healthcare system(uincare homeplus) which can supplement patients' rehabilitation at home by giving them proper instructions as well as feedback. in this prospective randomized controlled study, the investigators aim to compare the efficacy of the newly-developed digital healthcare system with conventional rehabilitation program.

Eligibility criteria:
inclusion criteria: * patient who had total knee arthroplasty * patient who is discharged to home after surgery exclusion criteria: * patient who had previous history of high tibial osteotomy on the affected lower extremities. * patient who had history of lower extremities joint revision arthroplasty in the past 6 months. * patient who has severe comorbidity that inhibits exercise. * patient who has major neurological deficits on the lower extremities. * patient who cannot participate in post surgery rehabilitation

Keywords: total knee arthroplasty post-operative rehabilitation digital healthcare system
election - the electrode configuration cardiac resynchronization therapy (crt) study (election)

Conditions: Heart Failure

Summary: the electrode configuration crt study (election)

cardiac resynchronization therapy (crt) is an accepted treatment for selected heart failure patients. this therapy is delivered using a device (pacemaker (pm) +/- defibrillator (icd) ) and leads placed in the right atrium (ra), right ventricle (rv) and left ventricle (lv). rates of lv lead implantation failure and post operative lead related have decreased dramatically over the years, however, the incidence of lead dislodgement and phrenic nerve stimulation is still high. this study is a prospective evaluation of the benefits of having various pace/sense electrode configurations available in a crt system.

Eligibility criteria:
inclusion criteria: * patients selected for a guidant system, symptomatic heart failure, lv dysfunction, qrs width \> 120 ms, \> or = 18 yrs, able to understand the procedure, available for follow-up. exclusion criteria: * \< 18 years, life expectancy \< 6 months, expectation of heart transplantation during the study period, patients who have or are likely to receive a mechanical tricuspid valve, documented aortic stenosis, hypertrophic obstructive cardiomyopathy, inability or refusal to complete the follow-up at an approved centre, enrollment in another cardiovascular clinical investigation unless approved by the manager of clinical studies, guidant canada, inability or refusal to sign consent.
prediction of the collapse of necrotic femoral head using computed tomography scan and x-ray before hip arthroplasty

Conditions: Hip Arthropathy

Summary: to verify that ct scan and x-ray can predict the collapse of the necrotic femoral head before hip arthroplasty and effectively guide the surgical management.

osteonecrosis of the femoral head (onfh) is a common and frequently occurring disease. the main clinical manifestations are hip pain and dysfunction. the etiology and pathogenesis of onfh caused by various reasons are the problems that have not been solved yet in the field of orthopedics. if want to achieve satisfactory therapeutic effect, surgical choice is essential. it is very important for prognosis to master the indications of operation and take appropriate treatment measures, especially the great difference between palliative surgery and hip arthroplasty. to determine whether the femoral head collapses and the degree of collapse of the articular cartilage of the femoral head can help physicians to select an optimal surgical plan. chinese scholars commonly believe that if the femoral head collapse is less than 2 mm, investigators can choose autologous bone graft, allogeneic bone graft and other palliative surgery. if the femoral head collapse is more than 2 mm, investigators can choose total hip arthroplasty. however, above standard has not been extensively accepted worldwide.

Eligibility criteria:
inclusion criteria: * unilateral onfh confirmed preoperatively (ficat stages iii and iv; appendix 1)14 * unilateral total hip arthroplasty * age range: 32-68 years * irrespective of sex * sign the informed consent exclusion criteria: * infection * tuberculosis * tumor * severe osteoporosis
understanding adaptive immune response after covid-19 vaccination boosters to improve vaccination strategies in vulnerable groups.

Conditions: COVID-19

Summary: this is an experimental study without drug and device, non-profit, single-center. the general objective of the project is to study how the adaptive immune response evolves against sars-cov-2 with repeated vaccination boosters and infections also in relation to the evolution of variations. this study will be relevant to frail populations who are the main targets of repeated vaccinations. our project will benefit from the availability of a highly cohort characterized of vaccinated people, including cancer patients and elderly people, with prospective collection of samples for an in-depth evaluation of the evolution of the immune response with repeated exposure to doses of infection or vaccine. as part of the study, analyzes will be carried out on samples of patients enrolled in a manner prospective at the oncology departments of the irccs (medical oncology, department of radiotherapy advanced oncology and nuclear medicine) and elderly patients residing in retirement homes of the irccs. patients will also be asked for consent to store any residual samples in the tropica ditm biobank.


Eligibility criteria:
cancer patients inclusion criteria: * age\> 18 years. * solid tumor diagnosis \[i, ii, iii, iv stage,\]. * vaccinated with anti-sars-cov-2 vaccine or/and having history of past sars-cov-2 infections. * signed informed consent. exclusion criteria * age \< 18 years. * absence of signed informed consent. elderly subjects inclusion criteria: * age\> 70 years. * vaccinated with anti-sars-cov-2 vaccine or/and having history of past sars-cov-2 infections. * signed informed consent. exclusion criteria * age \< 70 years. * absence of signed informed consent.
immunonutrition and thoracoabdominal aorta aneurysm repair

Conditions: Thoracic Aortic Aneurysm; Respiratory Insufficiency

Summary: the purpose of this study is to determine whether immunonutrition and pre operative nutrition can reduce lenght of respirator support, lenght of stay in the icu and incidence of post operative infections

elective surgical repair of a thoraco (abdominal) aneurysm aorta (t(a)aa) is associated with high mortality and morbidity. important complications are renal failure, paraplegia and respiratory failure. a retrospective study we performed also revealed high post operative infection rates and high incidence of respiratory failure. improving immune status may reduce the occurrence of infections due to immune chances. immunonutrition may enhance the patient's immune system. many clinical trials of immunonutrition in critically ill and surgical patients have been performed. in meta-analyses it has been shown that immunonutrition results in lower infections rates and shorter 'length of stay' in hospital after major surgery. immunonutrition has not been studied yet in taa(a) surgery. controversy exists in septic patients. we designed a prospective randomized placebo controlled trial to study the effect of immunonutrition on time on ventilatorsupport, lenght of stay in the intensive care unit and incidence of postoperative infections after taa(a) surgery. patients start with oral supplements besides their normal diet 5 days before surgery. after the operation, the nutrition is continued by protocol and administered by nasogastric tube until normal entral feeding is possible. the control group wil receive iso caloric and iso nitrogen nutrition.

Eligibility criteria:
inclusion criteria: * patients scheduled for elective surgical repair thoracic or thoraco abdominal aneurysm exclusion criteria: * endovascular repair * pregnancy * immunodeficiency * use of immunosuppressiva * chronic obstructive lung disease

Keywords: thoracic aortic aneurysm immunonutrition respiratory failure lenght of stay icu
depression in the elderly and cerebral amyloid plaques: characterization by [18f] av-45 affectives symptoms and amyloïd plaques (asap)

Conditions: Elderly; Major Depression

Summary: the primary objective of the study is to compare the brain amyloid load in fully, partially and non remitting depressed elderly patients at 8 weeks of antidepressant therapy, by using pet with \[f18\]av45.

the main aim of this study is to assess the brain amyloid load in treated depressed elderly subjects using pet with \[f18\]av45. the investigators hypothesize that the brain amyloid load will be higher in non or partially remitting depressed subjects treated with antidepressants than in fully remitting ones. an additional two years follow-up will allow comparing the brain amyloid load at baseline between those who will have evolved towards mci or ma and those who will not, including apoe genotype, the cognitive performances at baseline, the hippocampus volume as assessed by mri, the type and profile of mood disorder (number of past episodes, age at first episode, vascular risk factor profile, response profile to antidepressants), as covariates.

Eligibility criteria:
inclusion criteria * adult 55 years or older * native language : french * study period \> 7 years * major depression defined on the dsm-iv criteria assessed by mini and hdrs score of 10 or over * affiliation to the national health insurance system * signed informed consent exclusion criteria * history of alcoholism or drug addiction * mmse less than or equal to 17 * major depression with psychotic features * depressive episode resistant, patient who received two different antidepressants well conducted without significant therapeutic response * any current or past episode of mania, schizophrenia or any other psychotic disorder * any past history of stroke or parkinson's disease * any current significant unstable illness * any past diagnosis of alzheimer's disease * any current treatment by acethylcholinesterae inhibitor, memantine or antidepressant therapy. * contraindications to mri in patients with: 1. metallic foreign body eye. 2. any implanted electronic medical irremovably (pacemaker, neurostimulator, cochlear implants ...) 3. metal heart valve, 4. vascular clips formerly located on cranial aneurysm. * contraindications to antidepressants * history of progressive disease that can affect the central nervous system such as uncontrolled diabetes, blood pressure greater than or equal to 180/100; chronic lung disease with hypoxia, head trauma with loss of consciousness greater than or equal to 15 minutes; brain surgery, encephalitis, recently treated cancer (\<1 year), altered cerebral metabolism including subjects with stroke sequelae extended. patients with lacunar stroke without thalamic or striatal may be included.

Keywords: affective symptoms as prodromal stage of alzheimer
concordance between 2 means of temperature measure in neutropenic patients hospitalized in intensive hematology care units

Conditions: Haematological Malignancy

Summary: connected medicine "2.0" is a major challenge that will lead in the near future to profound changes in medical practices. our study is part of this technological transformation, which is already taking the form of multiple devices available to practitioners: connected pill dispensers, integrated monitoring and surveillance systems (telemedicine), connected sensors, etc. however, a symptom as crucial and simple as body temperature has not been measured by real-time enteric capsule in a context of neutropenia. we therefore wish to study the concordance between the peripheral (tympanic) temperature and that measured by a capsule ingested in a cohort of patients hospitalized in the usih. if the measurements are clinically reliable and truly allow anticipation of antimicrobial treatments, a medico-economic evaluation will be proposed between the two options in the context of usih before its possible generalization.


Eligibility criteria:
inclusion criteria: * major patient admitted to usih for an aplasia episode of at least 7 days secondary to: * autograft conditioned by melphalan (mlp) or beam (bicnu, etoposide, aracytine, melphalan) chemotherapy * aracytin chemotherapy high dose (hd) or intermediate dose (di) * signed informed consent; * affiliated or beneficiary of a social protection scheme. exclusion criteria: * diarrhea (\> 3 stools /day) at the time of inclusion * occlusive syndrome at the time of inclusion or patient at risk of developing occlusive syndrome * persons with or likely to have intestinal disorders that may lead to obstruction of the digestive tract, including diverticulitis * people with digestive tract motility disorders * persons equipped with a pacemaker or an electro-medical implant * weight \ 30 * patient for whom an mri examination may be indicated during the trial period * patient with proven swallowing disorders * refusal to participate in the study * induction of acute leukaemia or allograft * person under guardianship or curatorship, or deprived of liberty by a judicial or administrative decision * pregnant, parturient or breastfeeding women; * patient unable to understand the study for any reason or to comply with the constraints of the trial (language, psychological, geographical problem, etc.) * patient who has already been included in the tempet trial during treatment

Keywords: temperature measurement capsule thermometers haematology
the efficacy of group-based unified protocol (up) programme for improving sleep and mental health

Conditions: Quality of Life; Insomnia; Depression, Anxiety

Summary: common mental disorders can be disabling and lead to a large burden of disease. unified protocol for transdiagnostic treatment of emotional disorders was developed to address emotional disorders with evidence-based emotional-focused cognitive-behavioural techniques and is efficacious in reducing anxiety symptoms and depressive symptoms in adults. previous research has demonstrated comparable effect of up on reducing anxiety symptoms compared with the single-disorder protocol (sdp) for anxiety. group-based up was also implemented and tested. given the fact that working populations are at a high risk of poor mental health, especially in light of the covid pandemic with new unprecedented work situations and increased uncertainties, the present study aims to investigate the efficacy of unified protocol on sleep and mental health in high-risk population.


Eligibility criteria:
inclusion criteria: * working in local schools or education institutions * aged 18 or above * no severe or unstable mental health conditions at recruitment * no extensive prior training/practice with mindfulness exclusion criteria: * psychotic disorders, bipolar disorder, severe alcohol disorder and substance abuse, acute and high suicidal risk * currently receiving taking other psychosocial interventions
dextran, a plasma expander, offers new hope for patients with decompensated liver cirrhosis and acute kidney injury

Conditions: Cirrhosis, Liver; AKI

Summary: a pilot study of dextran-40 infusion in patients with decompensated cirrhosis presenting with aki

a pilot study of dextran-40 infusion in decompensated cirrhotic patients complicating with aki. dextran-40® was administered at 1 g/kg/day for two days. aki reversal was defined when serum creatinine was \< 1.5 mg/dl. albumin infusion was given if aki reversal did not occur.

Eligibility criteria:
inclusion criteria: * decompensated cirrhosis with acute kidney injury * ager over 18 years old exclusion criteria: * having chronic kidney disease, severe heart or lung disease, severe sepsis * pregnant * receiving nephrotoxic agents * having history of allergic to dextran

Keywords: cirrhosis aki albumin dextran
water-jet assisted esd vs conventional esd technique for treating early gastric cancer

Conditions: Stomach Neoplasms

Summary: 1. introduction the aim of the study is to evaluate the efficacy and safety of esd by use of a new water-jet assisted esd system using the hybridknife® in patients with early gastric neoplastic lesions in comparison to the conventional esd established in japan. the water-assisted esd technology allows pressure controlled injection of fluids through the tip of a recently developed hybridknife®. submucosal injection, circumferential cutting and dissection of lesions as well as coagulation of bleeding can be performed with the same device without need for changing the instrument. these options should accelerate the procedure and may increase its safety and efficacy. 2. hypothesis the water-jet assisted esd technique using the hybridknife® bears the advantage of less instrument changes due to the combination of high-frequency cutting and water-jet application in one single instrument. this should lead to a simplified esd procedure, shorter learn-ing curve and especially to a shorter procedure time. the water-jet assisted esd technique should be shorter than the conventional esd techniques using it2-, dual- and hook-knifes at least with the same safety and effectiveness.


Eligibility criteria:
inclusion criteria: * adults (≥ 18 years) with confirmed diagnosis of gastric adenoma or early gastric adenocarcinoma * differentiated mucosal adenocarinoma without ulcer findings ≤ 60 mm in diameter. * lesions with ulceration ≤ 30 mm in diameter. * undifferentiated type of mucosal cancer is ≤ 20 mm. * the patient has given written informed consent. exclusion criteria: * pregnancy * coagulopathy (inr\>2.0, platelets \< 70/nl) * mucosal lesions which did not meet the inclusion criteria * evidence of local or distant metastases according to endoscopic ultrasound (eus) and/or ct scan, eus (7.5 mhz probe) findings of tumor infiltration into deep layers of the submucosa or muscularis propria. -patients unfit for deep sedation by use of propofol

Keywords: early gastric cancer, endoscopic submucosal dissection (esd) water-jet assisted esd
medication adherence to phone-supervised pancreatic enzyme replacement therapy

Conditions: Chronic Pancreatitis; Pancreatic Exocrine Insufficiency

Summary: this study aims to explore whether regular telephone intervention in patients with chronic pancreatitis can improve their pancreatic enzyme replacement therapy's medication adherence.

pancreatic exocrine insufficiency (pei) represents a significant complication in cases of chronic pancreatitis (cp), exerting considerable influence on patient quality-of-life outcomes. the latest iteration (2020) from acg's guidelines emphasizes pancreatic enzyme replacement therapy (pert) as pivotal in managing both symptomatic and asymptomatic cases among individuals with cp. pert not only extends median survival but also substantially mitigates symptoms while averting digestive complications associated with malabsorption-ultimately enhancing overall well-being. an analysis revealed varying levels of pert compliance across different patient groups-48% for those with cp, 52% for pancreatic cancer sufferers, and another 52% following pancreatic resection-induced pei-with these rates declining to approximately 20% within one year post-initiation. furthermore, findings from a limited-scale survey involving 148 individuals demonstrated that merely half exhibited satisfactory medication adherence; notably attributed to inadequate comprehension regarding prescribed regimens. presently lacking are established protocols aimed at bolstering pert medication adherence specifically tailored towards individuals affected by cp-a gap this investigation seeks to address through comprehensive educational initiatives coupled with sustained telephonic interventions.

Eligibility criteria:
inclusion criteria: * inpatients in the department of gastroenterology who met the clinical diagnostic criteria of chronic pancreatitis in the 2002 asia-pacific consensus opinion in changhai hospital; * at least 18 years of age; * have a mobile phone that can talk; * agree to complete the supervision and follow-up of pancreatic enzyme administration set up in this study through telephone communication. exclusion criteria: * refusing to participate in the study; * exclusion of difficult differential diagnosis: diagnosis of pancreatic cancer, groove pancreatitis, and autoimmune pancreatitis within 2 years after diagnosis of chronic pancreatitis; * pregnant or lactating women; * communication difficulties, mental and mental illness can not cooperate; * there are other reasons that researchers believe should not be included (alzheimer's disease, end-stage cancer, hiv, end-stage congestive heart failure, end-stage chronic obstructive pulmonary disease, decompensated cirrhosis, renal failure, etc.);

Keywords: chronic pancreatitis pancreatic exocrine insufficiency pancreatic enzyme replacement therapy medication adherence