Kornimate/medical-research-clean huggingface dataset:
hnscc immuno-genomics project

Conditions: Molecular Classification of HNSCC

Summary: for locally advanced and recurrent / metastatic head \& neck squamous cell carcinoma (hnscc), the is an unmet need for the development of efficient treatment combinations, particularly with immune checkpoint inhibitors. hnscc have been characterized at the genetic / molecular level concerning characteristics of malignancy and potential clinical actionability ; currently, however, the integration of molecular characteristics of both the malignant cells and the host immune response are considered fundamental for the selection of treatment that best suits these patients . the primary objective of the ncr-17-12885 project is to classify hnscc for the selection of optimal therapeutic interventions for the patients, based on genomic characteristics and mutational processes operating in these tumours and on the prevailing activated immune pathways.

herein we propose the development of a combined genomic and gene expression assay for the comprehensive evaluation of hnscc for the classification of tumors into (a) those with activated checkpoint molecules and activated t cells, likely to respond to checkpoint inhibition in the case of non-operable disease or recurrent disease without prior treatment; (b) those with inducible checkpoint and t cell response prior to the administration of checkpoint inhibitors; (c) those with activated early inflammatory response that needs to be transformed to cell mediated activation; and (d) those with stable genomes and no immune activation probably necessitating induction of genomic instability and t cell activation. the test to be developed will provide information on the genomic integrity of the tumor and on a global immune related gene expression profile, both by next generation sequencing

Eligibility criteria:
inclusion criteria: -patients with locally advanced squamous cell carcinoma of the head and neck who were treated with concurrent chemoradiotherapy (ccrt) with or without induction chemotherapy (ic) or radical surgery +/- radiotherapy for laryngeal tumors. exclusion criteria: * age \<18 years old * non-squamous cell carcinomas of the head and neck.

Keywords: head and neck cancer genomics immune-related gene expression
video-game based therapy in cerebral palsy

Conditions: Cerebral Palsy

Summary: the video-based therapy applications; will be applied in a non-three-dimensional (with desktop screen) way. in this application, there are different types of exercise programs that will work the upper extremity movements. the video-based therapy applications will be applied to individuals with cerebral palsy (cp) who will be included in the study with the xbox kinect 3600 (microsoft, washington, usa) device. this study was planned to examine the effect of video-based therapy on upper extremity selective motor control and proprioception in individuals with cerebral palsy.

spastic cp will be participate the study between the ages of 4 and 18 years. children's classified with gmfcs and macs. the eligible participants will be allocated two groups, including video-game based therapy group and conventional physiotherapy control group. all the assessments will be performed before and after the therapy in the 8-week therapy groups.the control group individuals will be given a conventional physiotherapy two days per week for a total of 8 weeks (conventional physiotherapy session will last 45 minutes). the video-game based therapy group will receive a conventional physiotherapy and video-game based therapy, two days a week for a total of 8 weeks (15 minutes conventional physiotherapy session+30 minutes video-game based therapy). all sessions will be performed in the clinic with the specialist physiotherapist.

Eligibility criteria:
inclusion criteria: * diagnosis of cerebral palsy voluntary participation, * age between 4-18 years * gmfcs level i-ii-iii * macs level i-ii-iii exclusion criteria: * not voluntary to participate in the research, * botox in the last 6 months, * upper limb or spine surgeries in the last 6 months

Keywords: cerebral palsy virtual reality video games upper extremity rehabilitation
comprehensive exercise training program during hospitalization for an acute cf exacerbation

Conditions: Cystic Fibrosis

Summary: this protocol was designed to assess if when subjects with cf are admitted to the hospital for a pulmonary exacerbation if a comprehensive exercise program (moderate to high intensity aerobic, resistance, flexibility and balance exercises) was superior to our "usual care intervention (30 min/day of self selected mode and intensity of exercise) in improving aerobic capacity, muscle strength/power, flexibility and balance.

this protocol was designed to assess if when subjects with cf are admitted to the hospital for a pulmonary exacerbation if a comprehensive exercise program (moderate to high intensity aerobic, resistance, flexibility and balance exercises) was superior to our "usual care intervention (30 min/day of self selected mode and intensity of exercise) in improving aerobic capacity, muscle strength/power, flexibility and balance. the experimental group will participate in the following regime: day 1 - evaluation including standardized tests and measures: if day 1 is a m,w, f, day 2 will constitute: aerobic exercise between 20-30 minutes based on patient tolerance using the appropriate rpe scale (13-15 on borg with patients ages 13-21, and 6-8 on pictoral cert with patients ages 6-12)to ensure correct intensity. choices will include treadmill, stationary bike, game bike, or ambulating at varying intensities throughout hospital; balance activities: standing on bosu ball while performing ue activity (throwing, catching with another ball, frisbee, etc.). standing on one leg or b le's will be determined by patients currently level. if day 1 is a tuesday or thursday, day 2 will constitute: 5-10 minutes of aerobic activity at warm up level (11-13 on borg, and 4-6 on pcert)x resistance training for ue: biceps, triceps, lattisimus, rhomboids/mid-trap, thoracic expansion exercises, and other muscles based on patient needs; resistance training for le: quadriceps, hamstrings, gluteals (especially maximus and medius), and other muscles depending on patient need, core and abdominal strengthening, stretches for flexibility depending on the patients individual needs: thoracic expansion stretches will be done with every pt. supine and sidelying. stretches are held for 10 seconds and repeated 10 times, hamstring stretches will be performed if pt unable to reach line with sit and reach test.

Eligibility criteria:
inclusion criteria: * age 6 to 21 years * admission for an acute cystic fibrosis (cf) exacerbation * forced expiratory volume in 1 s (fev1) of \< 60% of predicted at admission exclusion criteria: * medically unstable as deemed by the attending physician * had completed both arms of the present study

Keywords: cystic fibrosis; pulmonary exacerbation, exercise
rds multisense® spo2 calibration

Conditions: Hypoxia

Summary: data will be collected with the multisense® pulse oximetry system during non-motion conditions over the range of 70-100%. a clinimark reference system, previously correlated to arterial blood co-oximetry will be the basis for comparison. a minimum of fifteen (15) up to fifty (50) healthy adult subjects, ranging in pigmentation from light to dark, with at least six (6) subjects with dark pigmentation (fitzpatrick 5-6), will be enrolled in the study to meet the study design requirements defined by iso 80601-2-61 and by the fda's guidance for pulse oximeters (march 4, 2013). spo2 data will be evaluated during non-motion conditions. spo2 data will be evaluated during stable step plateaus of induced hypoxic levels. the investigational device will be placed on the thorax of the subjects (patch on the upper back and external electrode on the right pectoral). simultaneous data collection will be set up for the reference and the systems under test.


Eligibility criteria:
inclusion criteria: * subject must have the ability to understand and provide written informed consent * subject is 18 to 50 years of age * subject must be willing and able to comply with study procedures and duration * subject is a non-smoker or who has not smoked within 2 days prior to the study. * male or female of any race * subject demographics include a range of skin pigmentations, including at least 3 darkly pigmented subjects or 15% of the subject pool, whichever is larger. exclusion criteria: * subject is considered as being morbidly obese (defined as bmi \>39.5) * compromised circulation, injury, or physical malformation of fingers, toes, hands, ears or forehead/skull or other sensor sites, tattoo in the optical path which would limit the ability to test sites needed for the study. (note: certain malformations may still allow subjects to participate if the condition is noted and would not affect the particular sites utilized.) * females who are pregnant, who are trying to get pregnant, (confirmed by positive urine pregnancy test unless the subject is known to be not of child-bearing potential) * subjects who have smoked in the last 2 days with cohb levels \>3% as assessed with a masimo radical 7 (rainbow) * subjects with known respiratory conditions (self-reported) * subjects with known heart or cardiovascular conditions (self-reported, except for blood pressure and ecg review) or with an implantable active medical device such as pacemaker or automatic defibrillator * self-reported health conditions as identified in the health assessment form (self-reported) * subjects with severe contact allergies to standard adhesives, latex or other materials found in pulse oximetry sensors, ecg electrodes, respiration monitor electrodes or other medical sensors (self-reported) * unwillingness or inability to remove colored nail polish from test digits. * unwillingness to have chest or other test site shaved * other known health condition, should be considered upon disclosure in health assessment form

Keywords: hypoxia pulse oximetry spo2 remote monitoring connected device real-time monitoring
the effect of antimicrobial therapy on the serum level of p-cresol in peritoneal dialysis patients

Conditions: Chronic Kidney Disease

Summary: an important subgroup of protein-bound toxins are generated as a result of protein fermentation in the colon. p-cresol is a fermentation metabolite of tyrosine. in renal failure, the colonic generation rate of p-cresol is markedly elevated. after absorption, the majority of p-cresol is conjugated to form p-cresyl sulphate. there is clear evidence, both in vitro and in vivo, that accumulation of conjugated fermentation metabolites is correlated with clinical important endpoints. free p-cresol is an independent predictor for mortality in hemodialysis patients. moreover, in renal failure patients, neither hemodialysis nor peritoneal dialysis is capable of normalising the clearly elevated serum concentrations of p-cresyl sulphate. removal is at least partially diminished by the important protein binding of p-cresol. besides adaptation of renal replacement therapies to improve removal of protein bound solutes, another approach is to lower the generation of uremic toxins. the mechanisms underlying colonic carbohydrate and protein fermentation, responsible for the generation of p-cresol, are only partially understood. on the one hand, the ratio of fermentable carbohydrates to proteins has been shown to be an important determinant of protein fermentation. on the other hand, changes in the colonic bacterial flora influence the generation of p-cresol in dogs and in healthy human individuals. the effect of antibiotic therapy on bacterial protein fermentation and thus on the generation of p-cresol is not known. a reanalysis of data abstracted from a recent longitudinal study in peritoneal dialysis (pd) patients suggests that antibiotic therapy may lower p-cresol levels substantially. the current study aims at confirming these data in a prospective manner.


Eligibility criteria:
inclusion criteria: * age \> 18 * exit site infection, requiring antibiotic treatment * maintenance therapy with peritoneal dialysis exclusion criteria: * signs of peritonitis

Keywords: antibiotic p-cresol peritoneal dialysis
school-based interventions for test anxiety in adolescents

Conditions: Anxiety

Summary: this study evaluates the clinical and cost effectiveness of test anxiety as a form of selective prevention for clinical anxiety. participants will be randomly allocated to cognitive behavioural therapy without booster sessions, cognitive behavioural therapy with two booster sessions, or a no intervention control.

test anxiety affects a substantial proportion of adolescents, who show an increased risk of suicide, and of developing clinical anxiety and poor mental health. externally resourced school-based cognitive behavioural therapy (cbt) interventions have been shown to be effective in treating test anxiety. intervening in test anxiety, a sub-clinical anxiety, may prevent anxieties from developing into a clinical disorder. the primary outcomes are test anxiety, clinical anxiety, and wellbeing, measured at baseline, post-intervention, and 6 and 12-month follow-up. in addition, to identify treatment mechanisms additional measures are taken of uncertain control, metacognition, and emotional regulation.

Eligibility criteria:
inclusion criteria: * participants are aged 14-16 years of age * in the upper 66th percentile of test anxiety scores exclusion criteria: * participants are receiving other treatment for anxiety * participants have a diagnosis of clinical anxiety depression or attention deficit hyperactivity disorder

Keywords: test anxiety wellbeing
motivations, obstacles and opportunities for using a health application to encourage physical activity in people with chronic low back pain

Conditions: Chronic Low-back Pain

Summary: in industrialized countries, low back pain can be considered a priority health issue. some studies define it as one of the leading causes of disability in people under 45, or the leading cause of musculoskeletal disorders, with a prevalence of 26.9%. chronic forms account for less than 10% of acute episodes, but represent around 85% of costs. it has been recognized that rest and physical inactivity are not beneficial in the treatment of low back pain, and worse, increase the risk of chronicity. functional restoration of the spine (frs) programs have been introduced in rehabilitation centers, and have proved to be effective both physically and psycho-socially. patients generally adhere well to this type of program during in-center treatment. the effects obtained tend to fade rapidly on discharge, due to a lack of adherence to what can be offered conventionally (exercise sheets, oral advice). the development of connected tools (smartphones, tablets, etc.) could be a lever in this respect, as it would enable better patient support. in 2022, 84% of the population will own a smartphone. the content offered would be of higher quality, and would enable regular remote monitoring of the patient. the effects of the initial intensive treatment would be maintained by this new interactive, fun tool.


Eligibility criteria:
inclusion criteria: * major patients * chronic non-specific low-back pain. * diagnosis confirmed according to has definition (i.e. pain located between the thoraco-lumbar hinge and the lower gluteal fold. it may be associated with radiculalgia corresponding to pain in one or both lower limbs at the level of one or more dermatomes). patients included in the study must have given written informed consent. exclusion criteria: * patients not meeting has diagnostic criteria * patients with comprehension difficulties (making it impossible to fill in questionnaires) * patients with medical contraindications to physical exercise * patients under guardianship, curatorship or safeguard of justice. * patients without a smartphone

Keywords: chronic low back pain m-health smartphone qualitative study
sham controlled clinical trial of renal denervation in patients with resistant hypertension

Conditions: Hypertension

Summary: the purpose of this study is to assess the efficacy of catheter-based renal denervation in reducing blood pressure in patients with resistant hypertension compared to a sham procedure. patients will be randomized to rdn or sham control in a 2:1 ratio. all participants will be switched to a single pill triple combination treatment prior to the procedure. a total of 105 patients will be recruited into the study, 70 patients in the rdn arm and 35 patients in the sham control arm. the duration of this study is 36 months.


Eligibility criteria:
inclusion criteria: * systolic office bp ≥140mmhg and ambulatory day time average ≥135mmhg despite concurrent treatment with ≥3 anti-hypertensive drugs exclusion criteria: * renal artery anatomy ineligible for treatment * egfr \<15ml/min/1.73m2 (using mdrd calculation) * myocardial infarction, unstable angina or cerebrovascular accident within 3 months of screening visit * life expectancy of \<12 months * female participants of childbearing potential must have negative pregnancy test prior to treatment

Keywords: renal denervation blood pressure cardiovascular risk target organ damage sympathetic activity non-compliance
single-plane versus real-time biplane approaches for ultrasound-guided hip joint injection: a prospective randomized controlled clinical study

Conditions: Hip Pain

Summary: the goal of this clinical trial is to compare the safety and accuracy of single-plane and real-time biplane ultrasound imaging in guiding hip joint injections and explore the application effects of imaging technology in hip joint injections.

real-time biplane imaging, an emerging ultrasound technology, uses a three-dimensional (3d) matrix transducer to display simultaneously he longitudinal and transverse intersecting planes on a single screen without requiring rotation of the transducer. the modality displays the puncture path in real-time and exhibits the spatial relationship between the needle tip and the target site, as well as surrounding structures during guided puncture. this technology significantly improves the puncture success rate and reduces complication rates in procedures such as the placement of intrahepatic bile duct drains and central venous catheters. however, this technology has not yet been implemented for hip joint injections. therefore, we compared the safety and accuracy of single-plane and real-time biplane ultrasound imaging in guiding hip joint injections and explored the application effects of imaging technology in hip joint injections.

Eligibility criteria:
inclusion criteria: 1.15 to 80 years of age; 2.hip joint pain and/or limited hip joint mobility; 3.physical examination and imaging studies indicating hip joint pathology; 4.pain duration exceeding 6 months with no significant improvement after conservative treatment; 5.patients scheduled for hip arthroscopy. exclusion criteria: 1. a history of hip joint surgery; 2. the presence of lumbar disease, ankylosing spondylitis, or sacroiliac-joint pathology; 3. femoral head necrosis; 4. drug allergies; 5. inability to cooperate, or other contraindications to puncture.

Keywords: hip joint puncture injection single-plane real-time biplane
"association splitting" in obsessive-compulsive disorder (ocd)

Conditions: Obsessive-Compulsive Disorder

Summary: over a period of 3 weeks, association splitting is compared to cognitive remediation (cogpack training) as an add-on intervention to cognitive-behavioral therapy (cbt). blind to treatment assignment, both groups are assessed before intervention and eight weeks as well as six months later with the yale-brown obsessive compulsive scale (y-bocs), the obsessive-compulsive inventory (oci-r) and cognitive tests. ocd severity as measured by the y-bocs total score serves as the primary outcome parameter. it is assumed that association splitting will improve ocd severity to a greater extent than cognitive remediation.

association splitting is a new cognitive technique which aims at reducing obsessive thoughts. it draws upon the so-called "fan effect" of associative priming. transposing this principle to the treatment of obsessive-compulsive disorder (ocd), we hypothesized that the sprouting of new and the strengthening of existing neutral associations to core ocd cognitions will reduce their fear-evoking properties by depriving the chain of ocd-related cognitions of associative strength. patients with ocd are randomly allocated to either associations splitting (as) or cognitive remediation (cogpack training). blind to treatment assignment, both groups are assessed before intervention and eight weeks as well as six months later with the yale-brown obsessive compulsive scale (y-bocs), the obsessive-compulsive inventory (oci-r) and cognitive tests. ocd severity derived from the y-bocs and the oci-r serves as the main outcome parameters. we also explore if as changes the ocd-related semantic networks with cognitive tasks. it is assumed that association splitting will improve ocd severity to a greater extent than cogpack training.

Eligibility criteria:
inclusion criteria: * obsessive-compulsive disorder (ocd) with an y-bocs obsession subscore ≥ 8 exclusion criteria: * intellectual disability (iq \< 70); unable to provide informed consent; severe neurological illness, psychotic symptoms or substance dependence.

Keywords: ocd obsessions cognitive
dialysis exercise with a bed compatible leg trainingstool

Conditions: Chronic Kidney Diseases; Hemodialysis

Summary: this study is a randomised controlled intervention trial for dialysis patients with chronic kidney disease (n=32). the aim of this study is to test the effectiveness of an intradialytic training with a simple bed compatible trainingstool in comparison to a control group.

patients are randomised to either the intervention or control group at the beginning of the study. both groups are evaluated at the beginning and after 2 months regarding their body composition, physical performance, fatigue and quality of life. the control group receives usual care. the intervention group receives an intradialytic exercise training with a bed compatible trainingstool.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years * patients who started dialysis more than 3 months ago * patients must be mentally and physically able to participate in exercise exclusion criteria: * patients who are not mentally or physically able to participate in intradialytic exercise. these include patients with uncontrolled high blood pressure and uncontrolled diabetes mellitus, diseases that impair physical performance or/and could be aggravated by activity, such as ischaemic cardiopathy or symptoms associated with coronary heart disease, chronic coronary heart disease, chronic lung disease and orthopaedic conditions that make exercise impossible.

Keywords: dialysis intradialytic exercise hemodialysis training