Kornimate/medical-research-clean huggingface dataset:
analysis of correlation of amplitude-integrated eeg and neurodevelopmental outcome in preterm infants

Conditions: Brain Activity; Neurodevelopmental Outcome

Summary: the study included analysis of longitudinal recordings of amplitude-integrated eeg (aeeg) tracings on a weekly basis in preterm infants and evaluation of their neurodevelopmental outcome at the age of three years. aim of the study was to observe if there is a correlation of the aeeg tracings of the first weeks of life to later neurodevelopmental outcome and to evaluate if aeeg can be used as prognostic tool.

from the first week of life on aeeg-recordings were obtained on a weekly basis and the results of the first eight weeks of life were analyzed for this study. aeeg-tracings were analyzed with regard to background activity (percentages of continuous and discontinuous patterns), the presence/absence of sleep-wake-cycles and the occurrence of seizure activity. these items where summed up in a score including three grades (normal, moderately and severely abnormal). the aeeg was recorded as a single channel eeg from biparietal surface disk electrodes using a cfm (cfm 5330, lectromed devices ltd., uk) or the cfm 6000 (olympic medical, usa). assessment of neurodevelopmental outcome was done at three years of age by assessment of the bayley scales of infant development ii (bsid-ii) during the study period from january 1st 2000, and december 31st 2002 a total of 284 preterm infants less than 30 weeks´ gestational age were admitted to the neonatal intensive care unit of the medical university of vienna. neurodevelopmental outcome could be obtained in 148/284 infants at the age of three years and these infants therefore fulfilled the inclusion criteria for this study

Eligibility criteria:
inclusion criteria: * gestational age \< 30 weeks exclusion criteria: * brain malformation * inborn error of metabolism

Keywords: aeeg preterm infants predictive value outcome
the heart failure readmission intervention by variable early follow-up (thrive) study

Conditions: Heart Failure

Summary: this study is a pragmatic randomized clinical trial to determine the effectiveness of two strategies of early follow-up in adults after hospitalization for heart failure: telephone follow-up with a heart failure care manager vs. in-person clinic visit with their primary care provider. the primary outcomes during 30-day follow-up will include readmission for heart failure, death and readmission for any cause. the study team aims to randomly assign 2400 patients during a 15-month period in a 1-to-1 ratio to either an initial structured telephone call with a heart failure care manager or an in-person primary care clinic visit within 7 days of discharge. a secondary goal is to increase the rate of any follow-up within 7 days of discharge to greater than 90 percent among all eligible patients.

heart failure (hf) affects \>5 million adults nationally and is the leading cause of hospitalization among medicare beneficiaries. reducing hospitalization for heart failure (hf) and subsequent readmissions shortly after discharge is a nationally recognized health care delivery system priority. more than 20% of medicare patients hospitalized for hf are readmitted within 30 days and this rate has not been declining over the past decade despite increasing attention to this problem. the data that will be collected could allow the study team to tailor the post-discharge follow-up program to patient characteristics to further improve the effectiveness of the interventions.

Eligibility criteria:
inclusion criteria: * all eligible patients hospitalized for confirmed acute heart failure at a kaiser permanente northern california medical center exclusion criteria: * planned discharge to a location other than their home. this includes a skilled nursing facility, nursing home or hospice facility. * planned discharge to home with hospice care. * end-stage renal disease treated with chronic peritoneal dialysis or hemodialysis. * death during the index hospitalization.
clinician-patient communication in lung cancer care

Conditions: Lung Cancer

Summary: the purpose of this study is to better understand communication between patients with lung cancer and their clinicians. the investigators are also interested in patient's perceptions of the quality of communication with his/her clinician and how these perceptions may impact patient outcomes. the clinician participating in this study and has given us permission to approach his/her eligible patients for study participation.


Eligibility criteria:
inclusion criteria: * patients with confirmed lung cancer diagnosis or mass suspicious of lung cancer as per clinician report and/or emr * lung cancer diagnosis or suspicious mass as per clinician report/emr within 0-6 months of consent or within no more than three visits to participating clinician * participating clinician approves his/her patient's participation in this study per clinician report. * former (at least 100 cigarettes in lifetime and quit more than 30 days prior to enrollment) or current smoker (lifetime smoker who reports cigarette smoking within the past 30 days) as per self report or emr; * english fluency (determined through emr or clinician report), as we do not have the resources to translate the consultations from other languages or the surveys to other languages; * patients must be 18 years old or older clinician inclusion criteria: * an msk attending physician (radiologists, medical oncologists, and surgeons), nurse practitioner (np), physician assistant (pa), fellow, resident or clinical nurse specialist (cns) or clinical nurse (rn) who is a member of the thoracic disease management team or pulmonary service currently treating thoracic patients at msk as per self report * clinical has individual clinic consultations to discuss adult health assessment and/or smoking history with the target patient population: english-speaking, at least 18 years of age, has a suspicious lung mass or confirmed diagnosis, is a former/current smoker, has had no more than 3 visits with clinician or had diagnosis in past 6 months as per self-report. exclusion criteria: clinician exclusion criteria * n/a

Keywords: clinician-patient communication 16-001
imaging young myeloma (imagerie jeune myélome)

Conditions: Multiple Myeloma

Summary: multicenter open-label prospective comparative study of pet-scan and mri at the time of diagnosis, after 3 cycles of induction therapy (rvd) and at the completion of therapy.


Eligibility criteria:
inclusion criteria: * symptomatic de novo multiple myeloma * less than 65 years of age * enrolled in the ifm/dfci clinical trial exclusion criteria: * 66 years of age or more * not eligible for high-dose therapy * cons-indications to mri or pet-scan

Keywords: mri pet-scan multiple myeloma prognosis pharmacoeconomic analysis
radiological evaluation of sarcopenia in patient received chemotherapy

Conditions: Sarcopenia

Summary: radiological evaluation of sarcopenia in patients receiving chemotherapy

evaluation of muscle mass by using sonoelastography and computed tomography

Eligibility criteria:
inclusion criteria: * all cancer patients receiving chemotherapy referred to radiodiagnosis department for routine examination patients must be between 18 and exclusion criteria: * previous or current history of any musculoskeletal or neurological disorder including strokes. * systemic atrophy affecting cns ( huntington disease ,hereditary ataxia ,spinal muscular disorder and related syndromes ,post polio syndrome ) * central nervous system demyelinating disease ( multiple sclerosis , acute disseminated demyelinated syndromes.. * corticosteroids undertaken currently or for the past 3 years with doses \>5mg/day.
effects of amantadine on postoperative cognitive dysfunction

Conditions: Postoperative Cognitive Dysfunction

Summary: post-operative cognitive dysfunction (pocd) is a fairly well-documented clinical phenomenon. investigators will determine whether amantadine can reduce the occurrence of pocd in elderly patients with major abdominal surgery.

patients who are 60 years old or older for laparoscopic abdominal surgery will be randomly assigned into two groups: 1) no-treatment group, and 2) amantadine-treated group. each group will have 150 patients. in addition, investigators will need 90 subjects in the control group. the data of these control subjects will be used to normalize the data of the two studied groups to diagnose pocd. the subjects in control groups will also be elderly but without the exposure to anesthesia and surgery.

Eligibility criteria:
inclusion criteria: 1. major elective gynecological, prostate or bladder surgery patients who are ≥ 60 years old. 2. the surgery is laparoscopic surgery and is expected to last for ≥ 2 hours under general anesthesia and the patient will stay in hospital for at least 7 days after surgery. 3. lack of serious hearing and vision impairment and be able to read so that neurobehavioral tests can be performed. exclusion criteria: 1. patients are not expected to be alive for longer than 3 months. 2. mini-mental state examination (mmse) \[18\] score ≤ 23. 3. history of dementia, psychiatric illness or any diseases of central nervous system. 4. current use of sedatives or antidepressant. 5. alcoholism and drug dependence. 6. patients previously included in this study (for patients who have second intra-abdominal surgery during the study period). 7. difficult to follow up or patients with poor compliance. 8. uncontrolled hypertension (\> 180/100 mmhg)
a new theory of electrophysiological mechanism of atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the electrophysiological mechanisms of atrial fibrillation remain disagreements. the goal of this clinical trail is to propose a new electrophysiological mechanism hypothesis of atrial fibrillation（af）,meanwhile, the investigators sought to test the hypothesis that the superposition electrograms (spes) recorded during atrial fibrillation could be used as target sites for catheter ablation of atrial fibrillation.

catheter ablation for atrial fibrillation is a promising therapy, whose success is limited in part by uncertainty in the electrophysiological mechanisms of af. the investigators recruited 100 subjects including paroxysmal(40%) and persistent (60%) af. cases were prospectively treated, in a 2-arm 1:1 design, by ablation spes followed by pulmonary vein isolation(pvi) ablation (n=50), or pulmonary vein isolation alone (n =50). all procedures are guided by carto (biosense webster) electroanatomic mapping system and ablation is performed using open irrigated catheters with contact force (cf) sensing (thermocool smarttouch, biosense webster). study group underwent electroanatomic mapping during af. using carto to identify areas associated with spes. radiofrequency ablation of the area with spes was performed, aiming to eliminate spes and convert to sinus rhythm or atrial tachycardia.

Eligibility criteria:
inclusion criteria: * patients undergoing a first-time ablation procedure for af * paroxysmal af will be defined as a sustained episode lasting \> 7 days; persistent af will be defined as a sustained episode lasting \> 7 days and less than 1 years; long-lasting persistent af will be more than 1 year and less than 5 years. * patients must be willing and able to comply with all peri-ablation and follow-up requirements. * patients with atrial fibrillation will to accept the procedure of ablation. * patients signed the written informed consent for the study. * patients can endure the required follow up. exclusion criteria: * patients with contraindications to systemic anticoagulation with heparin or a direct thrombin inhibitor. * patients with thromboembolus in left atrial appendage. * patients with left atrial size ≥ 55 mm (2d echocardiography, parasternal long-axis view). * patients allergic for contrast or iodine. * patients with the serum creatinine（scr） \>3.5mg/dl * patients with life expectancy \< 12 months * patients who are in the period of pregnant
efficacy and safety of electrical versus pharmacological cardioversion in early atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the optimal strategy to restore sinus rhythm in patients with atrial fibrillation (af) of less than 48 hours' duration is still controversial. the investigators performed a controlled single-center trial to compare electrical and pharmacological (propafenone) cardioversion to restore the sinus rhythm in selected patients with acute atrial fibrillation.


Eligibility criteria:
inclusion criteria: * atrial fibrillation of less than 48 hours' duration. exclusion criteria: * af of more than 48 hours' * hemodynamic instability * acute onset atrial fibrillation due to acute coronary syndrome * electrolyte disturbances * sepsis * fever * hypothermia * untreated hyperthyroidism * use of antiarrhythmic drugs * high embolic risk * unclear duration of symptoms

Keywords: atrial fibrillation electrical cardioversion pharmacological cardioversion
microbiome comparison profile of normal skin and acne vulgaris patients

Conditions: Acne Vulgaris

Summary: the aim of this study is to compare the profile of the microbiome on normal skin and acne vulgaris patients. a cross sectional study with 144 samples, male or female between 18-40 years old, from january to may 2023.

recently, research on the role of the microbiome in the process of acne vulgaris has continued to grow. seeing the important role of the microbiome in maintaining the balance of skin health, this study aims to compare the profile of the microbiome on normal skin and on acne vulgaris patients, in order to gain a deeper understanding the role of the microbiome in acne vulgaris and also to compare skin microbiome features in various degrees of acne vulgaris severity. this research is an observational study with a cross sectional design. subject selected by consecutive sampling, with total 144 samples consists of males and females age 18-40. there will be two visits in this research. the first visit, for screening patients with requests for informed consent, giving facial soap, screening for inclusion and exclusion criteria, screening for facial skin complaints and facial care habits, collecting data on patient demographics and medical history, physical examination, sebumeter examination to measure sebum levels on facial skin, and taking clinical photos for documentation. the second visit is collecting microbiome data which will be taking in 1 to 2 weeks after the first visit. using swab method to take microbiome samples, after that, there will be dna extraction, amplification and sequencing were carried out on the sample and the shannon index will be calculated. then, the data will be tabulated and analyzed according to the hypothesis.

Eligibility criteria:
inclusion criteria: * male or female, 18-40 years old * normal individuals who have not had acne vulgaris in the last 5 years and have never had moderate or severe acne vulgaris * patients with mild, moderate, or severe acne vulgaris who have acne vulgaris lesions that are representative of the grade and equally distributed in all facial regions (forehead, cheeks, and chin) * patients agree to participate in the study and sign informed consent exclusion criteria: * pregnancy * diagnosed with other inflammatory or infectious diseases on the face * diagnosed with psoriasis or have atopic * diagnosed with primary or secondary immunodeficiency disease * patients with a history of laser therapy or facial dermabrasion within the past month * using oral or systemic antibiotics, anti-inflammatory, retinoids or hormone therapy in the last 1 month * using topical retinoid therapy, antibiotics, benzoyl peroxide, or other topical products in the last 2 weeks * acne conglobata

Keywords: skin microbiome normal skin acne vulgaris
the effectiveness of bilateral alternating tactile stimulation for improving sleep in children

Conditions: Sleep; Sensory Disorders

Summary: the investigators hypothesize that wearing bilateral therapeutic vibrating devices before bed will result in positive changes in outcome measures related to sleep (e.g., sleep efficiency) in children who are sensitive to stimuli in their environment (aka sensory over responsiveness or sor).

the purpose of this research study is determine if providing bilateral alternating stimulation to the extremities is effective for improving sleep in children with sensory processing difficulties. the investigators will use touchpoints to deliver the intervention. the touchpoints look like a regular watch, and vibrate at different low level frequencies to produce a calming effect on the body. more information about touchpoints can be found here: https://thetouchpointsolution.com/pages/shop-touchpoints. the investigators hypothesize that these types of wearable vibrating devices may help children fall asleep faster and possibly stay asleep longer. this study will allow the research team to test these assumptions. in this study, each child will be asked to do the following things: 1. wear an activity tracker watch on their wrist before bed and through the night for 10 days consecutively (baseline) 2. wear both the activity tracker watch (wrist) and the touchpoints (both ankles) before bed and during sleep for 10 days straight. (intervention) 3. wear the activity tracker watch on their wrist before bed and through the night for 10 additional days (post-test) during the study, the parents will be asked to fill out a brief sleep diary.

Eligibility criteria:
inclusion criteria: * scores "more than others" in either sensation avoiding or sensory over-responsive on the short sensory profile * has identified sleep difficulties on the children's sleep wake scale (any sub-scale scores outside of normative range) exclusion criteria: * diagnosed seizure disorder or history of seizures * rubber or latex allergy (will not be able to wear wrist band) * significant motor impairments (e.g. cerebral palsy) * children who are wards of the state

Keywords: sleep sensory over-responsiveness hypersensitivity
long term cognitive impact of pediatric acute renal injury

Conditions: Acute Kidney Injury

Summary: the research study will investigate the longitudinal cognitive outcomes in subjects admitted as children diagnosed with sepsis who may have had acute kidney injury. each subject will be contacted 2-15 years after their incident admission in order to solicit responses to a functional and cognitive quality of life survey. children admitted during the same time frame that did not have kidney injury will also be surveyed.

250 subjects with a prior admission for pediatric sepsis will be contacted 2-15 years following the incident admission in order to complete a survey to assess their overall quality of life. children will be administered the pediatric quality of life (pedsql) survey with a parental section to allow for parental response. adult subjects will take the adult version of the pedsql.

Eligibility criteria:
inclusion criteria: * subjects may be adults or children who were admitted to the hospital with a severe infection between january 1998 to december 2014. * consent from adult or parent/guardian of child to participate in study. * assent from subjects between 7 and 17 years of age. exclusion criteria: * failure or inability to complete the survey * participant is unable to understand written or spoken english * subjects between 7 and 17 years of age unwilling to assent.
cardiac 3d mri in pediatric cancer patients

Conditions: Childhood Cancer

Summary: this is a non-randomized prospective pilot study in a single academic center with historic controls. this study will compare cardiac magnetic resonance images (mri) of patients who have undergone childhood cancer treatment that has cardio-toxic effects to historic controls. the ultimate goal of this study is to develop a safe and effective method for early diagnosis of heart problems in children who are receiving chemotherapy treatments that may be toxic to the heart.

the following tests and procedures will be performed after consent has been obtained. all tests and procedures noted below are being done for the sole purpose of the study: visit 1. subjects will be asked to complete some questionnaires and answer questions regarding smoking status and use of alcohol or smokeless tobacco. we will also gather basic information such as age, height, weight, gender, ethnicity, race, pertinent medical history as well as collect vital sign information (height, weight, blood pressure, heart and respiratory rate.) next, subjects will undergo a routine transthoracic echocardiogram. visit 2. following the completion of the echocardiogram, and if selected to take part in the study, subjects will be schedule for a cardiac mri test within a 3 months period. when subjects come in for visit 2, they will receive a 12 lead electrocardiograph (ecg) before the cardiac 3d mri. all females who are capable of becoming pregnant, except those who are age 11 and under, will then undergo urine pregnancy testing. if it is found that you are pregnant you will not be allowed to be in the study. if the female is under 18 and a positive pregnancy test result is obtained, we will inform both the participant and her parent/guardian. subjects may then be placed in a "simulated" mri to teach them what it will be like to enter the scanner and also train them on how to breathe calmly and regularly during the scan. training will involve the use of a primesense 3d sensor, similar to the cameras used in active videogame systems such as the xbox kinect, which will generate a 3d picture of their chest as they breathe. following this training session, subjects will then undergo cardiac 3d mri. study participations will end after this visit.

Eligibility criteria:
inclusion criteria: * childhood cancer treatment which has been completed * received anthracyclines as part of childhood cancer treatment, at least 150 mg/m2 as cumulative dose * normal left ventricular systolic and diastolic functions on echocardiogram exclusion criteria: * ongoing cancer treatment * pregnancy * inability to undergo a cardiac mri * abnormal ventricular systolic or diastolic function on echocardiogram

Keywords: childhood cancer anthracyclines cardiotoxicity cardiac mri cumulative does of at least 150 mg/m2 of anthracyclines ventricular function