Kornimate/medical-research-clean huggingface dataset:
prioritising prevention of covid-19 in persons with cancer in the french west indies

Conditions: Cancer

Summary: the public health council (haut conseil de santé publique) published a statement on 14 march 2020 relating to the management of patients with severe forms of covid-19, stipulating specific recommendations for patients with cancer. the statement notes that patients with cancer at much higher risk (four to five times higher) of several respiratory complications, which develop very rapidly, especially if they had recently undergone surgery or chemotherapy in the previous few weeks, and that this risk could be life-threatening, on top of the cancer-related risk. in addition, the statement noted that: * covid-19 appears to be more frequent in patients with cancer than among the general population (1% vs 0.29%) * among those infected, the risk of severe respiratory complications requiring admission to the intensive care unit (icu) is higher in patients with cancer than among those without (39% vs 8%, p=0.0003). * a history of chemotherapy or surgery in the previous months is an important prognostic factor for the development of severe respiratory complications (odds ratio (or) = 5.34, p= 0.0026). * deterioration of respiratory function occurs more quickly in patients with cancer (13 vs 43 days, hazard ratio (hr) 3.56, 95% confidence interval (ci) \[1.65-7.69\]). in addition, covid-19 may lead to a change in the diagnostic and therapeutic management of patients with cancer, with potential consequences such as use of oral treatments at home, discontinuation of anticancer therapy depending on the context, or prioritization of management according to curative/palliative treatment type, age, and line of therapy. international studies previously reported the psychological repercussions of major epidemics on the emotional state. the impact of covid-19 on patients with cancer therefore warrants evaluation, among cancer patients in the french west indies, in the current situation of nationwide lockdown.


Eligibility criteria:
inclusion criteria: * patients aged 18 years or older living in the french west indies * patient with prevalent cancer of the prostate, breast, lung, colon or rectum * patients who receive the information leaflet and do not express any opposition to the use of their personal medical data exclusion criteria: * patients who are unable to answer the study questionnaires * patients who do not speak fluent french * persons under legal protection

Keywords: psychiatry public health
infant-directed singing for at-risk mothers and infants

Conditions: Maternal Behavior; Infant Behavior

Summary: the purpose of this study is to figure out if mothers can learn how to use singing to help their babies. singing can help babies calm down or encourage them to play, both of which are needed for learning.


Eligibility criteria:
inclusion criteria: mothers: * must have infants enrolled at the linda ray intervention center (lric). * must be 18 years of age or older * must be able to read and write in english infants: * must be enrolled at the linda ray intervention center (lric). * must be at least 3 months and no older than 12 months. exclusion criteria: - participants who are not enrolled at the linda ray intervention center (lric).
acute pancreatitis and coagulation study

Conditions: Acute Pancreatitis

Summary: the study aims to investigate pathophysiological changes in coagulation in relation to inflammation in patients with acute pancreatitis. serum and plasma is sampled repeated days from admission. analysis will be done after recruitment. specific biomarkers accuracy for prediction of moderate and severer acute pancreatitis will be calculated.

inclusion criteria: patients with acute pancreatitis admitted to skåne university hospital in malmö acute pancreatitis is defined as minimum 2 out of following: amylase levels \>3 times upper reference limit, clinical signs of acute pancreatitis, imaging findings of acute pancreatitis) exclusion criteria: \<18 years of age \>72 hours from onset of symptom until first sampling patients with immunosuppression or autoimmune diseases are excluded from som parts of the study. methods: serum and plasma is sampled repeatedly during the hospital admission. pre defined protocols are used for data collections of relevant clinical information. specific aspects of inflammation, thrombin generation, platelet function and microparticles will be analysed in serum or plasma during the first consecutive days of acute pancreatitis. biomarkers for severe disease as well as correlation between inflammation and coagulopathy will be investigated.

Eligibility criteria:
inclusion criteria: acute pancreatitis, accept informed consent - exclusion criteria: more than 72h from onset of symptoms until first sample, patient already included once -

Keywords: acute pancreatitis biomarkers severity prediction
evaluation of lvef by a new automatic evaluation tool in a pocket ultrasound scanner

Conditions: Echocardiography; Medicine, Emergency; Technology Assessment, Biomedical; Heart Diseases

Summary: clinical ultrasound has become essential in emergency medicine. the guidelines are to use of echocardiography in specific contexts: dyspnea, hypotension or chest pain. the evaluation of left ventricle ejection fraction (lvef) is one of the basic objectives of echocardiography. the reference assessment in emergency medicine is visual assessment. it suffers from poor inter-observer reproducibility. pocket ultrasound scanners seem to meet the constraints of point-of-care ultrasound. a new tool is available on a pocket ultrasound device: the automatic evaluation of lvef. its interest could be to have a better inter-observer reproducibility than visual evaluation.


Eligibility criteria:
inclusion criteria: * patient over 18 years of age * management in the investigator centre * admitted for dyspnea or hypotension or chest pain exclusion criteria: * age \< 18 years * patient not benefiting from a social security system * patient deprived of liberty * patient under the protection of justice, under guardianship or curatorship * patient refusing to participate in the study * inability to provide the patient with informed information
correlation between psa levels and f-18 psma pet/ct findings in prostate cancer patient

Conditions: Prostatic Neoplasms

Summary: it is a cross sectional study aimed to correlate between psa levels and f-18 psma pet/ct scan findings and to evaluate the impact of pet/ct findings on the patient management

prostate cancer (pc) is a prevalent malignancy that occurs primarily in old males, it is the third most common with regards of mortality (1,2). prostate-specific membrane antigen (psma) known as glutamate carboxypeptidase ii, is a transmembrane glycoprotein highly expressed in pc cells. psma expression tends to increase with increased pathological gleason grade and is thought to be upregulated with the emergence of androgen independence (2). psma pet/ct imaging is important for correct primary staging and for the detection of sites of biochemical recurrence. prostate-specific antigen liu et al., in 2022 stated that as serum psa levels increase, the diagnostic accuracy of f-psma-1007 pet/ct also improves (3) bergero et al., in 2022 evaluated the diagnostic correlation between psa and positivity of f-18 psma pet/ct in patients with biochemically recurrent prostate cancer (rpc), reporting it as a very good predictor of positivity in 18f-psma pet/ct in patients with rpc (4). a meta-analysis in 2022 found that the detection rate (dr) of the18f-psma-1007 pet/ct was also improved with increasing serum psa levels (5) another meta-analysis in 2019 studied the dr of f-18 psma pet/ct revealing that dr is related to psa values with significant lower dr in patients with psa\<0.5 ng/ml (6)

Eligibility criteria:
inclusion criteria: * male patients with pathologically proven prostate cancer who will be referred to nuclear medicine unit to perform f18 psma for different indications exclusion criteria: * undifferentiated prostate cancer. * studies with motion artifacts, or those in which patient can't stay stable or calm during acquisition. * severely ill patients that hinder imaging.

Keywords: psma pet/ct, prostate, psa
the using postoperative ketamine and exploring the effect on endometriosis pain (upkeeep) study

Conditions: Endometriosis; Post Operative Pain

Summary: this is a randomized, single blinded, placebo-controlled trial to study the effectiveness of a subanesthetic dose (0.6 mg/kg) of ketamine versus placebo (saline) on postoperative pain and pain on adult female chronic pelvic pain patients undergoing robotic removal of endometriosis. the objective of the study is to explore the effect of a sub anesthetic dose of ketamine (0.6 mg/kg) vs. saline control on postoperative pain and recovery in chronic pelvic pain patients who have undergone robotic removal of endometriosis.


Eligibility criteria:
inclusion criteria: 1. adults, aged 18 to 65 years old 2. experiencing chronic pain, defined as experiencing moderate to severe pelvic pain for greater than 6 months 3. scheduled to undergo robotic endometriosis removal surgery 4. willing to comply with all study procedures and be available for the duration of the study. 5. subject is medically stable. exclusion criteria: 1. cognitive impairment (by history) or clinical signs of altered mental status such as confusion, amnesia, disorientation, fluctuating levels of alertness, etc. that may interference with adherence to study procedures and/or participant safety. 2. past ketamine or phencyclidine misuse or abuse 3. schizophrenia or history of psychosis 4. known sensitivity or allergy to ketamine 5. liver or renal insufficiency. 6. history of uncontrolled hypertension, chest pain, cardiac arrythmia, stroke, head trauma, intracranial mass or hemorrhage or pressure, glaucoma, acute globe injury, uncontrolled thyroid disease, porphyria, or any other contraindication to ketamine. use of lamotrigine, alfentanil, physostigmine, and 4-aminopyridine are contraindicated 7. pregnancy or nursing women 8. currently participating in another pain interventional trial 9. unwillingness to give informed consent 10. non-english-speaking patients as the ehp-30 instrument has only been licensed to nyulh in english.
motivational interviewing nutrition exercise obese adolescents

Conditions: Adolescent Obesity

Summary: this study is a randomized controlled study in a quasi-experimental design in the pre-test post-test design.the aim of this study is to examine the effect of motivational interview applied to obese adolescents on nutritional exercise behavior, anthropometric measurements and sedentary activity level.the data of this study were collected using a personal information form, nutrition exercise behavior scale, adolescent sedentary activity questionnaire and anthropometric measurement form.in this study, nursing initiatives include a mg-based training program that will be given to obese adolescents in the experimental group in the form of 6 sessions after collecting preliminary test data. the final tests will be collected after 3 months of follow-up. pre-test and post-test will be applied to the adolescents in the control group. each training will take 30 minutes. various training methods and techniques such as oral expression, question and answer, brainstorming, feedback and powerpoint presentations will be used within the scope of the training program

obesity has been increasing in children and adolescents as well as adults in recent years. many factors play a role in the formation of obesity. the most important of these are sedentary lifestyle, wrong diet and insufficient physical activity. motivational interviewing technique seems to give promising results in order to change risky health behaviors that cause obesity in adolescents. this study is a randomized controlled study in a quasi-experimental design in the pre-test post-test design.the aim of this study is to examine the effect of motivational interview applied to obese adolescents on nutritional exercise behavior, anthropometric measurements and sedentary activity level.the data of this study were collected using a personal information form, nutrition exercise behavior scale, adolescent sedentary activity questionnaire and anthropometric measurement form.in this study, nursing initiatives include a mg-based training program that will be given to obese adolescents in the experimental group in the form of 6 sessions after collecting preliminary test data. the final tests will be collected after 3 months of follow-up. pre-test and post-test will be applied to the adolescents in the control group. each training will take 30 minutes. various training methods and techniques such as oral expression, question and answer, brainstorming, feedback and powerpoint presentations will be used within the scope of the training program.

Eligibility criteria:
inclusion criteria: * being above the 95th percentile * not going to a dietitian exclusion criteria: * having mental health problems

Keywords: obesıty motivational interviewing sedentary actıvıty nutrıtıon exercıse
support and tracking to achieve results (project star)

Conditions: Obesity

Summary: the investigators propose to conduct a randomized controlled trial assessing the impact of phone-based extended care delivered on an adaptive (when participants are at "high risk" for weight regain as assessed by a predictive algorithm) vs. static (gold-standard, once-per-month frequency) schedule on weight loss maintenance. the study team will provide participants with an initial behavioral weight management program, and then randomize participants who successfully achieve a clinically-significant weight loss of ≥5% to one of the two extended-care conditions

obesity remains a substantial public health challenge in the united states. while behavioral lifestyle interventions have been demonstrated to produce weight losses of 8-10% in adults with overweight and obesity, long-term outcomes are suboptimal, limiting effectiveness for long-term weight loss maintenance. the study team will evaluate methods for providing phone-based extended-care to support weight loss maintenance. the investigators propose to conduct a randomized controlled trial assessing the impact of phone-based extended care delivered on an adaptive (when we determine that participants are at "high risk" for weight regain) vs. static (once-per-month frequency used in gold-standard extended-care programs) schedule on weight loss maintenance. participants will be provided with an initial in-person, group-based behavioral weight management program. participants who successfully achieve a clinically-significant weight loss between baseline and month 4 (defined by the institute of medicine as a reduction in weight of ≥ 5% from baseline) will be randomized into the clinical trial. follow-up visits will occur at month 12 and month 24 after initial intervention baseline.

Eligibility criteria:
inclusion criteria: * bmi 30.0-45.0 kg/m2 * own a smartphone \[apple iphone (5s or newer) or android smartphone (kitkat os 4.4 or newer)\] with a cellular and data plan * weight ≤ 396 pounds (due to scale limit) * lose ≥ 5% of baseline weight during the initial weight loss intervention (month 0 to month 4) * completion of baseline assessment measures exclusion criteria: * history of bariatric surgery * current use of weight loss medications * weight loss of ≥ 10 lb in prior 6 months * physical limitations that prevent walking ¼ mile without stopping * use of a pacemaker * currently pregnant * currently breastfeeding * less than 1 year post-partum * plans to become pregnant within the study period * lack of written approval for participation from potential participant's physician if the participant has been diagnosed with type 2 diabetes, hypertension, or has a history of coronary heart disease * more than one participant per household (enrollment limited to one participant per household) * medical conditions that contraindicate weight loss or prevent completion of the study (e.g., current diagnosis of cancer or terminal illness, dementia, or plans to relocate during the study period)

Keywords: weight loss weight maintenance
treatment with ux007 for a single patient with glut1 deficiency syndrome

Conditions: Glucose Transporter 1 Deficiency Syndrome

Summary: this treatment plan is intended for the use of ux007 (triheptanoin) in the treatment of a single patient with glucose transporter 1 (glut1) deficiency syndrome.

this treatment plan is intended for the use of ux007 (triheptanoin) in the treatment of a single patient with glucose transporter 1 (glut1) deficiency syndrome. patient has already tried the other acceptable treatments for glut1 with either side effects that caused treatment to be discontinued (ketogenic diet) or a current treatment that is not showing any efficacy and is difficult to sustain for a long duration given this patient's age (modified atkins diet). due to the patient's ongoing neuroregression and lack of other viable treatments, the use of ux007 (triheptanoin) is warranted. there is no comparable or satisfactory alternative therapy to treat this patient's severely debilitating condition and the potential benefits to the patient justify the potential risks of the treatment. the potential risks from ux007 (triheptanoin) are not unreasonable given the context of this patient's condition.

Eligibility criteria:
inclusion criteria: * this treatment plan is intended for the use of ux007 (triheptanoin) in the treatment of a single patient with glucose transporter 1 (glut1) deficiency syndrome. exclusion criteria: * not applicable as study only includes one patient.
the efficacy of olfactory training intervention on olfactory and other non-motor symptoms in pd

Conditions: Parkinson Disease; Olfactory Disorder; Olfactory Training

Summary: to explore the efficacy of olfactory training on olfactory and other non-motor symptoms in pd.


Eligibility criteria:
inclusion criteria: 1. pd was diagnosed according to the criteria of movement disorders and parkinson disease group of chinese society of neurology of chinese medical association. 2. olfactory score was 1 standard deviation lower than the corresponding age norm; 3. no medication plan in the past four weeks or no change in medication plan in the past four weeks, which can be maintained until the end of the experiment; 4.40-75 years old, with normal vision, hearing and language understanding and expression ability; 5.good cooperation of patients exclusion criteria: 1. parkinson\&#39;s syndrome and parkinson\&#39;s plus syndrome caused by cerebrovascular disease, encephalitis, trauma, drugs, etc.; 2. neuropsychiatric diseases that may affect the sense of smell, such as depression, anxiety, schizophrenia, etc.; 3. history of nasal disease or surgery, such as rhinitis, sinusitis, nasal septum deviation, etc. upper respiratory tract infection in the past 3 weeks; 4. long-term smoking and occupations that inhale chemical irritants for a long time.

Keywords: parkinson disease olfactory disorder olfactory training
a study of gastric delay in migraine patients (3207-003)

Conditions: Migraine Disorders

Summary: a study to assess safety and pk of an investigational drug in migraine patients during and between migraine attacks.


Eligibility criteria:
inclusion criteria: * non-smoking male or female between 18 to 45 years of age * patient typically has between 2 and 10 migraine attacks per month, rated as moderate or severe exclusion criteria: * patient has any other medical conditions other than migraine
the effect of repeated standardized patient use on students' anxiety and learning levels in teaching extremity examination skills

Conditions: Nursing Students

Summary: aims: this study aimed to examine the effects of peer assessment and repeated standardized patient use on students' self-confidence and anxiety and their psychomotor skill performance in teaching extremity examination skills. design: this randomized controlled experimental study was carried out following the consort checklist. methods: the study sample consisted of second-grade nursing students enrolled in the " health diagnosis" course in the fall semester of the 2023-2024 academic year (n:67). the students in the peer assessment group performed the upper and lower extremity examinations once whereas those in the standardized patient group performed these examinations three times. research data were analyzed in ibm spss 25.0 (statistical package for social sciences) software. the shapiro-wilk test was used to check whether the data were normally distributed. parametric and nonparametric tests and descriptive statistical methods were used for data analysis. the significance levels were taken as p\<0.001 and p\<0.05. the scales used were analyzed with the cronbach alpha reliability coefficient; the scenarios and forms created by the researchers were evaluated with the lawshe technique.


Eligibility criteria:
inclusion criteria: * second-grade nursing students * enrolled in the " health diagnosis" course at the faculty of health sciences, department of nursing of a university in the fall semester of the 2023-2024 academic year exclusion criteria: - students who actively continue their nursing profession as well as their education life

Keywords: anxiety self-confidence active learning passive learning psychomotor skills standardized patient peer extremity
weight fluctuation after breast cancer treatment

Conditions: Breast Cancer; Weight Gain

Summary: this study aims to identify and quantify the factors associated with excess weight gain following treatment for breast cancer. it is believed that breast cancer patients gain more than 4% of their weight at diagnosis which is likely accompanied by an increase in body fat and waist circumference. it is further thought that this excess weight and increase in body fat and waist circumference are associated to tumour characteristics, chemotherapy, menopause status at diagnosis and the presence of genes related to obesity. it is also thought that women treated with chemotherapy have higher levels of glucose and insulin.


Eligibility criteria:
inclusion criteria: * females 18 years of age or older. * diagnosed with breast cancer between 1/1/2003 and 31/12/2007. * able to understand and willing to sign informed consent. exclusion criteria: * known diagnosis of previous breast/other cancer (other than completely resected non-melanoma skin cancer or successfully treated in situ cancer of the cervix. * known diagnosis of inflammatory bowel disease or malabsorption syndrome. * known diagnosis of endocrine problems associated with the development of obesity (cushings syndrome, hypo/hyperthyroid, thyroiditis) * treatment for psychiatric disorders.

Keywords: weight breast cancer
effect of gabapentin on pain of the second cataract surgery

Conditions: Hyperalgesia

Summary: gabapentin pretreatment may reduce hyperalgesia occurring at the second surgery in serial, bilateral cataract surgery.

hyperalgesia occurring at the second operation in bilateral eye surgery is well known, and mechanism of central sensitization might be involved. gabapentin is known to lower the effect of central sensitization, and its effect on acute postoperative pain has been reported. therefore, pretreatment of gabapentin after first operation may reduce the pain at second operation.

Eligibility criteria:
inclusion criteria: * patient of asa(american cociety of anesthesiology) class i, ii, iii between age 20 to 80, scheduled for serial bilateral cataract surgery(1 weel interval) exclusion criteria: * refuse to participate * bmi\ 30 * severe cardiovascular, pulmonary, renal disease * alcohol or drug abuse * currently taking cns(central nervous system) inhibitory drugs * taking antiacids * depressive disorder pregnancy

Keywords: serial cataract surgery hyperalgesia gabapentin central sensitization