Kornimate/medical-research-clean huggingface dataset:
outcome of full pulpotomy using calcium silicate based materials

Conditions: Carious Teeth

Summary: permanent teeth with carious pulp exposure and indicated for full pulpotomy will be treated using three different materials using aseptic technique and will be subsequently followed up clinically and radiographically at 6 months, 1 year and yearly up to 5 years.

* the target sample size is 150 patients medically fit, having vital teeth with carious pulp exposure and complaining of pain. * the patients tooth will receive full pulpotomy under aseptic conditions and it will be randomly assigned to one of 3 calcium silicate based materials namely, (mineral trioxide aggregate (mta), biodentine, and bioceramic for capping the full pulpotomy followed by resin composite restoration. * follow up for pain levels will be done during the first week. * clinical and radiographic examination will be done at 6 months, 1 year and yearly up to 5 years. * success of the procedure includes absence of clinical signs and symptoms, with absence of pathology in the root and periapex on periapical radiographs. * the 3 materials will be compared in terms of clinical and radiographic outcomes. * demographic data of the three groups will be also compared * predictive factors of success will be also analyzed * tooth color changes will be also measured using vita easy shade and will compared between the groups at 6 months and 1 year.

Eligibility criteria:
inclusion criteria: * mature permanent tooth with carious lesion exposing the pulp, * positive response to cold test * clinical diagnosis of reversible or irreversible pulpitis * restorable tooth by direct restoration or crown * healthy patient exclusion criteria: * non vital teeth * teeth without pulp exposure * inability to achieve hemostasis within 10 min after pulpotomy * non restorable teeth or teeth that require post and core restoration

Keywords: teeth, caries, pulpotomy, mta, biodentine, bioceramic
combined rehabilitation with ala, alc, resveratrol and vitamin d in discogenic sciatica in young people

Conditions: Sciatic Radiculopathy

Summary: the objective of this interventional case-control clinical study is to evaluate the effectiveness of physiotherapy combined with the administration of alpha lipoic acid, l-acetylcarnitine, resvelatrol, vit d3 in the treatment of sciatica due to herniated disc in young patients. the main questions we intend to answer are: * is this combined treatment more effective in reducing pain? * is the combined treatment useful for improving postural alterations, reducing the intake of painkillers and the number of days of absence from work and improving the quality of life?


Eligibility criteria:
inclusion criteria: * age 18-45 years * pain with nrs scale score between 5 and 7 points * symptoms attributable to lumbosciatica which occurred no more than 4 weeks ago * pharmacological wash out of nsaids and corticosteroids for at least a week * presence of l4-l5, l5-s1 disc herniation diagnosed with lumbar mri performed within 3 months * absence of ongoing infectious episodes; * written consent for participation in the study. exclusion criteria: * altered states of consciousness; * sciatica not of disc origin * neurological disorders * presence of scoliosis \>20° of cobb * previous spinal surgery * pregnancy and/or breastfeeding
large-scale ex vivo expansion and characterization of two kinds of msc from knee for clinical application

Conditions: Knee Injuries

Summary: according to many researches, mesenchymal stem cells (msc) isolated from synovial membrane and infrapatellar fat pad have higher ex vivo proliferation capacity, multipotency and ability to undergo chondrogenesis. based on this concept, the investigators plan to get two removed tissues (synovial membrane and infrapatellar fat pad) from patients who have an operation of tkr (total knee replacement). the investigators are going to isolate and expand msc from these two tissues respectively, and then compare their characterization and potential for clinical application. in the other hand, the investigators plan to build techniques and procedures which comply with "good tissue practices (gtp)".


Eligibility criteria:
inclusion criteria: patient who have an total knee replacement surgery exclusion criteria: patient who don't sign the agreement
reducing burden in care partners of community-dwelling persons with dementia and oropharyngeal dysphagia

Conditions: Caregiver Burden; Alzheimer Disease; Dementia; Oropharyngeal Dysphagia

Summary: the goal of this clinical trial is to learn if a newly-created website tool, called wecaretofeeddysphagia, helps to reduce feelings of burden in care partners of patients with alzheimer's disease and related dementias (ad/adrd) who were diagnosed with trouble swallowing (oropharyngeal dysphagia). the main questions this first test (pilot) study aims to answer are: * with the data this pilot study will collect, how do we best measure how strong a relationship is between care partners who use wecaretofeeddysphagia and reduced feelings of burden (effect size estimates)? * is it possible (feasible) to successfully repeat this study in a larger clinical trial with more research participants? researchers will compare a group of care partners who have access to the wecaretofeeddysphagia tool (intervention) to a group of care partners who do not have access to the tool. both groups will receive contact information for help from a speech language pathologist expert (enhanced usual care). participants will: * be given access to the web tool and receive 3 text message reminders over 3 weeks to use the tool (intervention group only). * be asked to complete a remote, web-based survey three times: when enrolled in the study, at 1 month following patient leaving the hospital, and at 3 months following patient leaving the hospital.


Eligibility criteria:
inclusion criteria: * self identifies as the primary care partner of an older adult patient (patient aged 65 years or older) with alzheimer's disease and related dementias (ad/adrd) and oropharyngeal dysphagia (od) admitted to the northwell health medicine service * care partner age 18 years or older * designated as the legally authorized representative (lar) or health care proxy (hcp), or designated by the lar or hcp to participate * proficient in english * has access to a device (e.g. smartphone, ipad, computer) capable of accessing a web browser exclusion criteria: * care partner of patient with a percutaneous feeding tube \[i.e. percutaneous endoscopic gastrostomy (peg) tube, percutaneous endoscopic jejunostomy (pej) used exclusively\] * care partner of patient who will not be discharged to the home or community setting (e.g., home, assisted living, independent living) * care partner will not be involved with od management (e.g. buying or making food, feeding, supervising) after hospital discharge
humoral and cellular i̇mmune response to sars-cov-2 mrna bnt162b2 vaccine in children with chronic kidney diseases

Conditions: Chronic Kidney Disease 5D; Chronic Kidney Disease 5T

Summary: coronavirus 2019 (covid-19) infection is associated with higher morbidity and mortality in adult patients on dialysis, and kidney transplant recipients (ktrs). although children had lower morbidity and mortality, ktrs are more vulnerable than healthy children. it has already known that the general immune responses to vaccines, which are currently in practice (attenuated, conjugated, or recombinant) were lower than healthy controls in children and adolescents on dialysis and with a kidney transplantation. uremic milieu and immunosuppressive drugs are the factors causing impaired immune response in this group of patients. the new mrna vaccine technology is used worldwide including children and adolescents during the pandemic. studies have demonstrated lower immune response to new sars-cov-2 mrna vaccine in adult ktrs. however, there is limited data about vaccine-induced immune response in children and adolescent with renal replacement therapy. the aim of this study was to assess immune response to sars-cov-2 mrna bnt162b2 and its clinical and laboratory correlates in children and adolescent ktrs. humoral immune response was assessed by anti-sars-cov-2 immunoglobulin g (anti-s igg) and its clinical correlate neutralizing antibody (nab). cellular immune response was assessed with sars-cov-2 specific interferon ɣ release assay (igra).

this is a prospective, multicenter case-control study performed between september 2021 and march 2022 in the pediatric nephrology units of iu- cerrahpaşa school of medicine, memorial hospital, marmara university school of medicine, iu- istanbul school of medicine, medeniyet university school of medicine, and istinye university school of medicine. the control group has consisted of age and gender comparable 19 healthy children without any acute infection or chronic disease, who were admitted to cerrahpasa school of medicine, pediatric out-patient unit for routine control. when permitted by local guidelines, children and adolescents who were over 12 years old were notified of vaccine eligibility and encouraged to schedule an appointment. the sars-cov-2 mrna bnt162b2 vaccine (pfizer-biontech®) administered to all participants by intramuscular route in the deltoid region. at least one month after the second dose of the vaccine, serum samples and whole blood samples were collected from all patients and controls, to analyze the humoral and cellular immune response to the vaccine. all samples were stored at -20 ◦c until testing. sars-cov-2 pcr test results were recorded retrospectively to determine natural infection.

Eligibility criteria:
inclusion criteria: * 12-21 year-old chronic kidney diseases and dialysis patients exclusion criteria: * patients with primary immune deficiencies and not vaccinated with sars-cov-2 mrna bnt162b2 vaccine * patients who did not completed 2 series of sars-cov-2 mrna bnt162b2 vaccine

Keywords: children chronic kidney disease covid19 vaccination antibody response
correlation of longterm wrist actigraphy recorded physical performance & 6-minute walk distance in patients with pulmonary arterial hypertension

Conditions: Pulmonary Arterial Hypertension

Summary: the objective of the study is to monitor physical activity longitudinally with a wrist activity tracker specifically in pah patients newly initiating era therapy and to assess the correlation with the 6mwd at different time points. further objectives are to assess the correlation of physical activity measured with the tracker and other parameters for clinical evaluation and right ventricular function assessment (i.e. biomarkers, who functional class, hospitalization due to pah, echochardiography and quality of life) as well as sleep efficacy in pah patients newly initiating era therapy.


Eligibility criteria:
inclusion criteria: * male or female patients with right heart catheter (rhc)-confirmed pah (who ph group i) * age ≥18 year * not receiving era therapy in the 30 days prior to the enrolment visit * signed patient informed consent form exclusion criteria: * patient with conditions that prevent compliance with the protocol or to adhere to therapy and use of the device
temporary hydrostatic splint therapy and its effects on occlusal forces

Conditions: Temporomandibular Joint Disorders

Summary: the goal of this non-randomized controlled trial is to analyze and compare occlusal force distribution patterns using t-scan iii before and after hydrostatic splint therapy on both healthy subjects and subjects with temporomandibular disorders. the main questions it aims to answer are: * do occlusal forces for individual teeth differ before and after hydrostatic splint therapy? * does the percentage distribution of forces across different sectors differ before and after hydrostatic splint therapy? participants will: * perform occlusal analysis using the t-scan iii device; * use a hydrostatic splint for 30 minutes; * perform a second occlusal analysis after using the hydrostatic splint. researchers will compare healthy subjects and subjects with temporomandibular disorders to see if hydrostatic splint therapy makes a difference in the distribution patterns of occlusal forces.


Eligibility criteria:
inclusion criteria: * healthy subjects with angle class i and a normal line of occlusion without malpositioned or rotated teeth; * complete permanent dentition except for the third molars; * no fixed prosthesis; * no dental caries; * no restorations on the occlusal surfaces of molars and premolars extending more than one-third of the surface; * no restorations on incisal edge; * no tenderness on percussion of any teeth; * no history of previous endodontic and orthodontic treatment, * extensive maxillofacial surgery; * no systematic neurological disorders. exclusion criteria: * presence of orofacial pain that limits mouth opening; * malocclusion (e.g., open bite, increased overjet or reverse overjet, cross bite); * skeletal anomalies with occlusal disturbance.

Keywords: occlusal splints dental occlusion balanced dental occlusion temporomandibular joint disorders bite force centric dental occlusion dental equipment
role of herbal based mouthwashes in plaque control

Conditions: Plaque Induced Gingival Disease

Summary: herbal medicine has been used for thousands of years. traditional herbal medicine is used by an estimated 80% of the world's population for primary health care. herbal treatments have gained popularity as a dietary supplement for illness prevention and as an alternative/complementary therapy in recent years. herbal remedies come in a wide variety of forms and can be found on the market all over the world.

herbal mouthwashes have been increasingly popular over time. ethnomedicines are the term used to describe them. various substances have been tested, with phytopharmacological analyses yielding contradictory results. many previous studies had tested the antiplaque efficiency of one herbal mouthwash with contradicting results, other studies have tested the antiplaque efficiency of chlorhexidine, tea tree oil and miswak, some studies had given positive outcomes and benefits of miswak on the gingiva and others when comparing between the efficacy of miswak over chlorhexidine mouth wash in dental practice provided results favouring both these mouthwashes. in our proposed study we will compare the antiplaque efficiency of three herbal kinds of mouthwash, miswak, tea tree oil and resveratrol mouthwash. plaque and gingival bleeding scores will be taken before the study from 6 different teeth and retaken after 2 weeks and four weeks respectively the use of the mouthwash. this study is single-blinded. antiplaque and gingival bleeding scores from the three mouthwashes will be recorded over a period of a month and statistical analysis will be performed

Eligibility criteria:
inclusion criteria: * patients who are medically fit * patients with gingival inflammation not progressed into periodontitis (aap classification * patients between the age of 18-60 years exclusion criteria: * patients who are medically compromised * patient who have undergone a periodontal therapy for the past 3 months * patients who are healthy but have been using herbal mouthwashes

Keywords: plaque gingival bleeding resveratrol miswak tea tree oil chlorhexidine
neuromuscular electrical stimulation on patellofemoral pain

Conditions: Patellofemoral Pain Syndrome

Summary: objective this study is to analyze the effects of an intervention protocol with neuromuscular electrical stimulation in the vastus medialis obliquus and gluteus medius (gm) associated with exercises on electromyographic activity, muscle performance, self-reported functionality and pain of women with patellofemoral pain.

this is a randomized, blinded trial in which 40 women, aged 18-30 years, will be randomized into 2 groups: stimulation and exercise group (seg) - will perform an exercise protocol associated with stimulation in the vastus medialis (vm) and gluteus medius (gm) muscles. exercises group (exg) - will perform the same protocol of exercises of the previous group, however, without association with neuromuscular electrical stimulation. the intervention will occur twice a week for eight weeks. all volunteers will be submitted to the evaluation of the electromyographic activity of the vm, the gm and the vastus lateralis, the dynamometric parameters, the intensity of the pain and the functionality, in four moments: 72h hours before the beginning of the intervention; after 4 weeks of intervention; after 8 weeks of intervention; after 16 weeks from the start of the intervention (eight weeks after the end of the protocol). in this way, the investigators will investigate the applicability of the proposed trial with the use of neuromuscular electrical stimulation and identify the effects of this resource in the treatment of pfp.

Eligibility criteria:
inclusion criteria: * present anterior or retropatellar pain during at least two of the following functional activities: sitting for long periods, going up or down stairs, running, kneeling down, crouching or jumping; * a minimum pain score of three on the numerical pain scale, at the last 24 hours, with insidious and non-traumatic onset of symptoms for at least one month. exclusion criteria: * history of surgery, trauma or an osteomioarticular system injury in the lower limbs in the last six months; * other pathology associated with the knee joint and could not have performed physical therapy treatment in the last twelve weeks; * body mass index greater than 30; * pregnancy or breastfeeding; * contraindications for the application of neuromuscular electrical stimulation; * intolerance or non-acceptance of electric current; * missing more than two intervention sessions.

Keywords: electromyography physiotherapy knee quadriceps muscle
information and communication technology (ict)- based centralized monitoring system of asthma control

Conditions: Asthma

Summary: the aims of this study is to evaluation of the clinical efficacy and stability of information and communication technology (ict)- based centralized monitoring system of asthma control monitoring in asthma patients. we planed to enroll 100 asthma patients (50 subjects using ict systems, 50 controls). we will monitor the asthma control status, lung function, exacerbation rate and stability of ict systems. this study is based upon work supported by the ministry of trade, industry \& energy (motie, korea) under industrial technology innovation program (no. 10059066, 'establishment of ict clinical trial system and foundation for industrialization').

this study has a multi- center, open- label, prospective and randomized clinical trial design. one hundred asthma patients who fill out the informed consent form are registered and randomized 1:1 into the ict-based centralized clinical trial monitoring group (n=50) or the ambulatory follow-up group (n=50). the planned follow-up duration is 6 months. he ict-based centralized clinical trial monitoring group is given home based spirometry and connecting system (gateway) equipped with personal identification system. fingerprint registration is required in advance, so that it would be used for authentication before each use of spirometry. symptom score and lung functions (fev1, pefr) obtained from gateway is saved, monitored, and sent out via a home-monitoring system. in the ict-based centralized clinical trial monitoring group, feedback is sent to both patients and medical staff in the form of texts if there is a worsening of symptoms score and/or lung function. subjects are to make office visits after randomization at 4, (8), 12, (16, 20), and 24 weeks. (ict group will not visit at the schedules in the brackets) each visit requires measurement of questionnaire (acq) lung functions.

Eligibility criteria:
inclusion criteria: * asthma patients diagnosed by doctors * current treatment with inhaled corticosteroid or leukotriene receptor antagonist * able to give written informed consent prior to participation in the study exclusion criteria: * subjects with plan of administration or operation within study periods * unstable heart disease and psychical disorder * refuse the monitoring

Keywords: ict based clinical trial, ecrf electronic -institutional review board (eirb), centralized monitoring contract research organization (cro)
prp & pdo threads in treatment of stress incontinence

Conditions: Stress Incontinence, Female

Summary: the study will include 10 women with pure or predominant sui symptoms, with severe urodynamic stress incontinence on urodynamics defined as loss of urine with sudden increases in abdominal pressure: eg, coughing, sneezing, or laughing). this will be conducted at the department of obstetrics and gynecology, faculty of medicine, al-azhar university. the purpose of study is to evaluate the efficacy and safety of platelets rich plasma combined with pdo threads in the treatment of stress incontinence in egyptian women.


Eligibility criteria:
inclusion criteria: * nonpregnant women with sui * age between 20 to 45 years * patients had a history of failed conservative treatment * patients were on the waiting list for surgical treatment of sui exclusion criteria: * under anti-platelet agent treatment * under nsaids * platelet dysfunction syndrome * critical thrombocytopenia * hypofibrionogenaemia * sepsis * acute and chronic infections * chronic liver disease * anti-coagulation therapy * history of malignancy * pregnancy * history of active malignant pathology * mental disorders making them unable to give consent * genitourinary fistula * pelvic organs prolapse stage \>2 according to the pelvic organ prolapse quantification system, and detrusor overactivity on urodynamics.
reducing hiv risks in african american teens

Conditions: HIV Infections

Summary: this study is developing and testing an innovative, parent education intervention, preparing our sons and daughters for healthy futures. this intervention aims to reduce hiv risk among african american and other black youth living in high-poverty urban neighborhoods. investigators, working with a community advisory board and focus groups of youth and parents, will develop a multi-year set of audio-cds to promote positive parenting practices that support young adolescents in establishing healthy patterns of behavior. this parent education intervention will be tested in a field trial with families of 6th graders recruited from multiple schools in new york city. baseline and annual follow up surveys will be conducted until youth enter high school. families receiving the intervention will be compared to those assigned to either an attention-controlled print materials condition or a non-attention controlled condition. it is hypothesized that youth whose parents receive the intervention will delay sexual initiation and report fewer sexual risks, and that their parents will report more positive parenting practices.


Eligibility criteria:
inclusion criteria: * attendance at selected schools * 6th graders and their parents exclusion criteria: * non-english speaking

Keywords: sexual health adolescent health parent education hiv seronegativity treatment experienced