Kornimate/medical-research-clean huggingface dataset:
acupuncture treatment of vasomotor symptoms in breast cancer patients

Conditions: Breast Cancer

Summary: the goal of this clinical trial is to evaluate the impact of acupuncture in preventing worsening of hot flashes and sleep disorders in paucisymptomatic premenopausal breast cancer (bc) patients undergoing lhrha plus endocrine therapy. according to the published data, acupuncture is an effective and long-lasting (6 to 8 months) treatment for severe vasomotor symptoms. treatment response can be affected by different variables, including intervention timing. the main question this study aims to answer is: can we expect an additional benefit resulting from an early intervention (when patients are still presymptomatic/paucysintomatic) with acupuncture in preventing worsening in terms of frequency/severity of hot flashes and sleep disorders? researchers will compare patients randomized in two arms: arm a: intervention with acupuncture arm b: usual care to see if acupuncture is superior to usual care in preventing worsening of hot flashes

this is a prospective randomized clinical trial of superiority of acupuncture compared to usual care for prevention/early treatment of vasomotor symptoms and sleep impairment in lhrha induced amenorrhea. the primary endpoint will be a reduction in frequency and intensity of hot flashes in the intervention arm compared to standard care, measured by the hot flash composite score (hfcs) at 6 months following the protocol. among the secondary outcomes, sleep quality will be measured by the pittsburgh sleep quality index (psqi) and quality of life by the menopause-specific quality of life questionnaire (menqol) and eortc quality of life questionnaire (eortc-c30). a total of 90 premenopausal bc (stage i-iii) patients undergoing lhrha plus endocrine therapy (tamoxifen or aromatase inhibitors) after surgery will be randomized 1:1 in two arms: arm a: intervention with 10 acupuncture sessions twice per week for 4 weeks followed by 2 more sessions once per week arm b: usual care participants in both arms will report the hot flash frequency and severity daily (hfcs), and will fill three questionnaires (eortc qlq-c30, menqol, psqi) according to the following timeline: t0 (baseline): 6 weeks following the first lhrha administration t1: 6 weeks from t0 (corresponding to the end of acupuncture protocol for arm a) t2: 18 weeks from t0 t3: 30 weeks from t0

Eligibility criteria:
inclusion criteria: * premenopausal breast cancer patients * stage i-iii breast cancer patients undergoing lhrha plus et (tamoxifen or aromatase inhibitors) after surgery * informed consent exclusion criteria: * ongoing lhrha during chemotherapy * ongoing pharmacological therapy or natural products consumption for vasomotor symptoms * metastatic breast cancer * ongoing heparin or anticoagulant therapy * psychiatric conditions

Keywords: breast cancer hot flashes acupuncture
a study assessing 13-valent pneumococcal conjugate vaccine in healthy chinese subjects

Conditions: Pneumococcal Infection

Summary: this study will assess the safety and tolerability of a single dose of 13-valent pneumococcal conjugate vaccine for approximately 1 month after vaccination sequentially in healthy chinese adults aged 18 through 55 years, followed by children aged 3 through 5 years, and then infants aged approximately 2 months.


Eligibility criteria:
inclusion criteria: 1. age at the time of enrollment is: * 18 through 55 years (before the fifty sixth birthday) for group 1. * 3 through 5 years (before the sixth birthday) for group 2. * 42 to 98 days for group 3. 2. healthy subject as determined by medical history, physical examination, and judgment of the investigator. exclusion criteria: * previous vaccination with licensed or investigational pneumococcal vaccine. * previous anaphylactic reaction to any vaccine or vaccine-related component. * contraindication to vaccination with pneumococcal vaccine.

Keywords: 13vpnc healthy subjects china
a study to evaluate the improvement effect on subjective symptom of fexuclue tab

Conditions: Gastroesophageal Reflux Disease

Summary: this observation study is a large-scale, prospective, and multi-organ observation study to observe the improvement effect of the self-evaluation results (pro) of erosive gastroesophageal reflux disease at least 4 to 8 weeks after administration of fexuclue tab.

this observation study is a large-scale, prospective, and multi-organ observation study to observe the improvement effect of the self-evaluation results (pro) of erosive gastroesophageal reflux disease at least 4 to 8 weeks after administration of fexuclue tab. subjects who met the inclusion/exclusion criteria will administer fexuclue tablet once a day for four weeks after registration, regardless of their meals. if esophagitis is not treated or symptoms continue after 4 weeks of administration, the subject will continue to administer fexuclue tablet for 4 more weeks (maximum administration period: 8 weeks).

Eligibility criteria:
inclusion criteria: 1. adult men and women aged 19 to 75 years of age at the time of registration. 2. a patient with erosive gastroesophageal reflux disease who is scheduled to administer fexuclue tab. for the first time based on the medical judgement of the researcher based on the medication authorization. 3. a person who voluntarily agrees to participate in this observation study and signed the informed consent form. exclusion criteria: 1. a person who falls under the prohibition of administration according to the permission for fexuclue tablet * patients with hypersensitivity to the components of fexuclue tablet or fexuclue tablet and a history thereof * patients undergoing atazanavir, nelfinavir or lilpivirin-containing preparations * pregnant and lactating women * patients with genetic problems such as galactose intolerance, lapp lactase deficiency, or glucose-galactose malabortion 2. a person who participates in another clinical trial and is administering (applying) clinical trial drugs or clinical trial medical devices; 3. in addition to the above, a person who has determined that the researcher (the doctor in charge) is not suitable for participation in this observation study
multimodal imaging analysis of spinal tumors

Conditions: Bone Tumor

Summary: in this study, we retrospectively analyzed the imaging data of spinal tumors to find out more imaging features of spinal tumors, in order to provide more accurate reference for the diagnosis of spinal tumors.

bone tumors account for 1-2% of total body tumors, and spinal tumors only account for 6.5% of total body tumors. because of the low incidence rate, the number of patients and the attention in this field are far lower than other tumors, so far, all the researches on spinal tumors are relatively lacking. because the diagnosis of bone tumor needs the combination of clinical, imaging and pathological to make a more accurate diagnosis, so the imaging diagnosis of spinal tumor is very important. in this study, through retrospective analysis of a variety of imaging data of patients with spinal tumor, measurement and recording of spinal tumor image related parameters, and statistical analysis, in order to find out more imaging characteristics of patients with spinal tumor, more accurate diagnosis of lesions, and provide more help for clinical decision-making.

Eligibility criteria:
inclusion criteria: * complete and accurate clinical and pathological data are available；imaging examination was performed in our hospital exclusion criteria: * patients with missing image data and unclear image
hypertension of our patients: knowledge, control, comorbidity

Conditions: Hypertension

Summary: numerous studies highlight the insufficiency of blood pressure control in treated hypertensive population \[1\]. as shown in the monica study, increased cardiovascular mortality is found in alsace compared to other french regions. the incidence and prevalence of diabetes and obesity are likely explanatory factors leading to this excess mortality \[2\]. furthermore, the incidence and prevalence of alsacian patients with end-stage renal failure (esrd) is also higher than the national average. the high prevalence of diabetes, hypertension and obesity in this population is also probably responsible for the high prevalence of esrd \[3\]. opportunities to prevent the progression of kidney disease involve an optimal control of treatable evolutionary factors. beyond control of diabetes and obesity, optimization of blood pressure control are an important factor to consider, as national and international guidelines recommend lower blood pressure targets in this population \[4\]. knowledge of the disease and treatment goals are a key component of hypertensive patient management. studies have shown that the knowledge of hypertensive disease and therapeutic targets were correlated with treatment compliance and with the rate of blood pressure control \[5\]. patient education and participation of non-medical actors (nurses, pharmacists, ...) are likely to improve the management and treatment compliance of these patients \[6\]. to our knowledge, no investigation has been performed in our region to determine the epidemiological characteristics, the knowledge level and blood pressure control in the population of hypertensive patients. the main objectives of this observational study are to evaluate, in a treated hypertensive population: the knowledge level of the blood pressure treatment goals, the impact of patient knowledge on this blood pressure control, the potential impact of the patient's comorbidities on his blood pressure control. such a study should provide the basis for the feasibility of a large survey.


Eligibility criteria:
inclusion criteria: * hypertensive patients moving spontaneously to their pharmacy to get their usual medications, including at least one drug in the class of anti-hypertensive exclusion criteria: * refusal or inability of the patient to respond to the questionnaire. * antihypertensive therapy changed in the month preceding the survey. * antihypertensive therapy initiated within three months preceding the survey. * age \<18 years.

Keywords: hypertension knowledge blood pressure control
behavioral intervention program based on motivational interview

Conditions: Periodontitis; Periodontal Diseases; Motivational Interviewing

Summary: the best way for dental professionals act using dialogue methods and individual approaches in daily clinical practice to change behavioral is still inconclusive. thus, the objective will be evaluate the effect of using motivational interviewing as part of the treatment of periodontitis in order to increase the adherence of adults to adequate oral health behavior.

patient-related approaches may show better results in treatment of periodontal diseases. the best way for the dental surgeon to act using these methods is still inconclusive. the aim of this study is to evaluate the effectiveness of using motivational interviewing as part of the treatment of periodontitis in order to increase adult adherence to adequate oral health behavior. a randomized clinical trial, with a sample size of at least 72 subjects, \>18 years of age and with at least 18 teeth, will be investigated. individuals in the test group will receive a collaborative communicative approach, inspired by the motivational interview, while the control group will receive the information/instructions in a conventional approach. the efficacy variables for evaluating the pattern of self-control of periodontal infection will be the bleeding on probing (bop), gingival index (gi, primary efficacy variable), the plaque index (pi) and patient-based outcomes will be assessed using quality of life questionnaires. additionally, questionnaires will be applied to obtain sociodemographic, behavioral and self-perception of oral health data. univariate and multivariate analyzes will be performed and conducted in the statistical products service solutions software (spss, version 25). thus, it will be possible to assess whether brief oral health education interventions centered on the individual can be used by dental surgeons in order to effectively improve oral hygiene behaviors in adults, obtaining better clinical results and a better quality of life for patients.

Eligibility criteria:
inclusion criteria: * adults, over 18-year-old; * bop (bleeding on probing) in at least 30% of sites; * diagnosed periodontitis. exclusion criteria: * smoking; * diabetes; * pregnancy (or the planning of pregnancy); * immunosuppressive illness or a medication, hepatitis, hiv, a bleeding illness or a anticoagulant; * a need for the antibiotic prophylaxis; * hyposalivation or use of medications that cause hyposalivation
vigamox treatment for ocular graft-versus-host disease

Conditions: Ocular Graft-versus-host Disease

Summary: in this study the investigators seek to prospectively measure the response of ocular graft-versus-host disease (gvhd) patients to treatment with topical vigamox. the investigators will accomplish this by enrolling patients with bilateral ocular gvhd and treating one eye with topical vigamox and the other eye with a placebo eye drop. by assessing the response to treatment with vigamox, the investigators hope to identify a role for topical antibiotic treatment in ocular gvhd.


Eligibility criteria:
inclusion criteria: -participants will be adults with a history of allogeneic hematopoietic stem cell transplantation, signs of either acute or chronic gvhd per the hematologist, signs and symptoms consistent with ocular gvhd + within 4 months of developing symptoms of ocular gvhd exclusion criteria: * treated with antibiotic eye drops in the month prior to enrollment * history of fluoroquinolone allergy * asymmetric ocular disease * pregnant * nursing

Keywords: gvhd graft-versus-host disease ocular surface ocular surface microbiome vigamox
analysis of bpd in premature infants with typical imaging changes

Conditions: Bronchopulmonary Dysplasia

Summary: bronchopulmonary dysplasia (bpd) is a common chronic respiratory disease in preterm infants. the increase in the survival rate of premature babies following the improvement of perinatal treatment and care has caused an increase in the incidence of bpd in recent years, which has seriously affected the quality of life of preterm infants. according to the consensus reached at the workshop sponsored by the national institute of child health and human development (nichd) in 2001, bpd was clinically defined based on oxygen dependency in preterm infants. however, the refined nichd definition of bpd in 2018 emphasizes imaging findings to support a diagnosis of lung parenchyma disease. fibrotic opacities and cystic changes on chest imaging (chest x-ray \[cxr\] or computed tomography \[ct\] scan) were considered typical findings in bpd patients. in patients with severe bpd, the presence of bubbles/cystic appearance on cxr after 28 days of life was reported to be an important factor, and typical imaging findings can predict a poor pulmonary outcome in bpd patients. bpd is associated with poor outcomes. although many studies have been conducted on bpd, there are limited reports specifically evaluating the association of typical imaging findings with clinical characteristics and later outcomes in patients with bpd. we hypothesized that bpd with typical imaging findings was likely to be a particular subgroup of this entity, with a unique etiology, clinical characteristics and prognosis. therefore, this retrospective study aimed to compare clinical characteristics, short-term outcomes and follow-up data until 2 years of age in preterm infants with or without typical imaging findings of bpd on cxr or ct scan during the entire hospital stay. a propensity score analysis was used to reduce bias between the two groups, and multivariate logistic regression analysis was performed to identify factors related to mortality in preterm infants with bpd.


Eligibility criteria:
inclusion criteria: (1) bpd diagnosis according to the 2001 nichd consensus; (2) chest imaging examination (cxr or ct) in the first week after birth; and (3) hospitalization within the first 7 days after birth. exclusion criteria: (1) major congenital malformations or laboratory-confirmed chromosomal abnormalities; (2) inadequate clinical data or missing chest imaging data; or (3) loss to follow-up.

Keywords: bronchopulmonary dysplasia typical chest imaging findings clinical characteristics outcomes preterm infants propensity score
clinical trial to assess the safety of a novel scaffold biomaterial

Conditions: Peripheral Neuropathy; Chronic Inflammatory Demyelinating Polyradiculoneuropathy; Vasculitic Neuropathy (Disorder); Amyloidosis; Hereditary Neuropathy; Sarcoid Neuropathy

Summary: this is safety study. subjects will be undergoing the surgical procedure of nerve biopsy. after routine surgery without grafting, patients develop swelling, redness, tenderness and dysesthesia at the biopsy site. in order to determine whether grafting is safe compared to not repairing the nerve, it is necessary to compare treated vs. untreated patients using systematic, sensitive and reproducible criteria.

patients will be evaluated for eligibility and then, after gaining informed consent, the surgical procedure will be scheduled. baseline evaluations include physical/neurological examination, nerve conduction study and ultrasonography of the sural nerve, and testing for erythrocyte sedimentation rate, c-reactive protein and complete blood counts (with white blood cell differential). surgery is done in an operating room under local or monitored anesthesia, depending on patient preference. an incision will be made above the ankle. immediately after the surgery, the patient will repeat the baseline physical/neurological exams, and sural nerve ultrasonography. participants will be evaluated either in the clinic or by phone on a regular basis and will be required to keep a journal and fill out symptom questionnaires for up to 12 months post-procedure. development of a grade 4 local reaction at any time will fulfill criteria for review by the data and safety monitoring board (dsmb) for implant removal and definition as a failure.

Eligibility criteria:
inclusion criteria * are between the ages of 18-75 years * have clinical indications for whole sural nerve biopsy * have a sural nerve snap with amplitude \> or = 2 microvolt (μv) * are able to comply with protocol requirements * can provide written informed consent * willingness to complete study procedures exclusion criteria * current smoker. * history of prior musculoskeletal (joint or soft tissue) infection. * pre-operative nares culture positive for methicillin-resistant staphylococcus aureus (mrsa) or methicillin-sensitive staphylococcus aureus (mssa) * have systemic immune disorders, such as crohn's disease, rheumatoid arthritis, or psoriasis with the exception of hyper/hypothyroidism. * have diabetes mellitus. * have previous trauma to the biopsy site. * have any major, clinically significant medical condition (e.g., within six months of baseline, had myocardial infarction, angina pectoris, and/or congestive heart failure) that, in the opinion of the investigator, would compromise the safety of patient. * are pregnant or breast-feeding. * unwilling to use adequate contraception.
sit less 4: how does reducing sitting time improve glucose and lipid metabolism?

Conditions: Overweight and Obesity

Summary: research has shown that replacing sitting time with low intensity physical activity (such as slowly walking and standing) has beneficial effects on metabolic health, like insulin sensitivity, comparable to improvements after sitting all day in combination with 1h streneous exercise. the main objective of this study is to investigate the underlying mechanisms responsible for improved insulin sensitivity after 4 days of sitting less compared to sitting and exercise in healthy obese women. our secondary objective is to investigate the effects of sitting less on cardio metabolic parameters.


Eligibility criteria:
inclusion criteria: * signed informed consent * caucasian * postmenopausal women * aged 45-70 years at start of the study * body mass index (bmi) 25 - 35 kg/m2 * stable dietary habits (no weight loss or gain \>5kg in the past 3 months) * sedentary lifestyle (not more than 2,5 hours of exercise per week in the past 3 months) exclusion criteria: * not able to complete the sitless try-out day according to the protocol * active diseases (cardiovascular, diabetes, liver, kidney, cancer or other) * no use of medication interfering with investigated study parameters (as determined by responsible physician) * alcohol consumption of \>2 servings per day * smoking in the past 6 months * participation in another biomedical trial which may have an effect on insulin sensitivity less than one month before the start of the study (screening visit) * mental or physical disability which interferes with physical activity * subjects with contra-indications for magnetic resonance imaging (mri) * reported participation in night shift work 2 weeks prior to the start of the study (screening visit) and during study participation. night work is defined as working between midnight and 6.00 am.

Keywords: insulin sensitivity sitting time
effects of visual art training on dementia

Conditions: Dementia

Summary: the purpose of the proposed study is to better understand what benefits visual art has on reducing problematic symptoms in dementia patients, including those with alzheimer's disease.

participants: participants will be residents, attendees and/or members of assisted living locations and/or dementia (or related) day programs. there will be two groups: an art training group and a waitlist control group. data analysis: 1. for primary measures, t-tests on pre-post difference scores comparing art training and waitlist groups. 2. for possible confounding effects, tests for confounds related to background factors (socioeconomic status, education level, gender, activity participation). procedure: a randomized controlled trial design will be utilized to assess two groups of dementia patients: an art training experimental group and a structured usual-activity waitlist control group. the experimental group will participate in a visual art training program and the waitlist control group will participate in their usual structured group activities. the waitlist control group will receive the art training program once post-testing is complete. before, during, and/or after the art programs and/or control activities, participants will be observed and complete assessments.

Eligibility criteria:
inclusion criteria: * dementia exclusion criteria: * inability to participate in the art training program due to physical or cognitive limitations