Kornimate/medical-research-clean huggingface dataset:
efficiency of the french translation social cognition and interactive training (scit)program

Conditions: Schizophrenia

Summary: social cognition and interaction training (scit), a group-based treatment that aims to improve both processing social information and functioning, may be an effective treatment for enhancing the social skills of people with schizophrenia. this study will compare the effectiveness of social cognition and interaction training (scit) versus treatment as usual (etp) in helping people with schizophrenia improve their social cognition and social functioning so specially on negative symptoms. many studies show a connection between negative symptom and social cognition in schizophrenia.

this is a multicenter (6 centers in france), randomized, controlled trial compared people aged 18 to 50 years with a diagnostic of schizophrenia according to the diagnostic and statistical manual of mental disorders, 4th edition (dsm-iv-tr), the social cognition and interaction training (scit) program will be compared to an already validated neurocognitive remediation program : therapeutic education program (etp) social cognition and interaction training (scit) is composed of three phases: emotion training, figuring out situations, and integration. social cognition and interaction training (scit) will be delivered by therapists in 20 weekly sessions over 5 months. 160 patients will be randomized as follows: - arm1, experimental: social cognition and interaction training (scit): 30h with therapist, videos and photos exercises - arm 2, control: therapeutic education program (etp): 30h with therapist, only discussion between patients.

Eligibility criteria:
inclusion criteria: * men and women aged 18 to 50 years old * diagnosis of schizophrenia according to the dsm-iv-tr * french speaker * unchanged psychotropic treatment during month preceding the inclusion * patients having given their consent lit to participate in the study * patients not having been part of therapeutic education program during six months preceding the inclusion * affiliated to the french social security exclusion criteria: * alcohol or drug dependence(according to the dsm-iv-tr),except tobacco * history of neurobiological illness or trauma * taking of medicine with somatic aim having a cerebral or psychic impact (ex: corticosteroids) * simultaneous participation on another program of cognitive remediation * the ineffectiveness of neuroleptic treatment

Keywords: social cognition cognitive remediation
compare the operating condition of two levels of muscle relaxation on facial nerve mep monitoring in cpa surgery

Conditions: Cerebellopontine Angle Tumor

Summary: compare the operating condition of two different levels of muscle relaxation on facial nerve monitoring using transcranial motor evocked potential in cpa surgery . * to estimate end to start facial nerve mep amplitude ratio * to determine the effect of neuromuscular relaxant degrees on recovery and * assessment of propofol doses needed for enhancement of early recovery and ambulation.

40 patients aged from 18-60 years old undergoing cerebellopontine angle surgery. patients will be one of two groups: both induction will be accomplished with fentanyl, propofol , rocronium infusion will be given randomly to one of the groups. depth of anaesthesia, neurotransmitter monitoring and facial nerve neurophysiological monitoring will be done.

Eligibility criteria:
inclusion criteria: * patients age between \>18 and\<60. * patients scheduled for neurosurgical cpa surgeries * ability to sign the consent * asa classification i, ii exclusion criteria: * asa \> ii * hemodynamically unstable * disease affecting neuromuscular transmission (myasthenia gravies ...etc.) * gcs \< 15. * any cardiac patient (ischemic heart disease - cardiomyopathy...etc.)
electrical impedence tomography with enlight2100

Conditions: Extubation

Summary: children with acute respiratory failure often need a breathing tube attached to a breathing machine, called a mechanical ventilator, to assist their breathing until they can recover. once the cause of respiratory failure has resolved or improved enough, the breathing tube can be removed, and that is called extubation. the extubation readiness test (ert) is a simple evaluation commonly performed in the intensive care unit to determine if a child is ready to have the breathing tube removed. the purpose of this study is to better understand how the ert and the eventual removal of the breathing tube affect where the air is in the lungs, and whether this can help predict which children will succeed or fail having the breathing tube taken out. this can done be at the bedside with a device called electrical impedance tomograph. this novel device is painless and uses a belt fitted with sensors placed around the chest to show where the air is in the lungs.


Eligibility criteria:
inclusion criteria: * patients less than 17 years of age admitted to the duke children's picu or pcicu with acute respiratory failure due to a pulmonary illness will be considered eligible for the study exclusion criteria: * patients with corrected gestational age less than 37 weeks * patients with contraindications to the enlight device (i.e. temporary or permanent pacemaker, vagal nerve stimulator, automatic implanted defibrillator, chest tubes that interfere with electrode belt placement, open chest wounds, unstable thorax, severe chest wall deformities) * known pregnancy * patients previously enrolled in this study will be excluded from participation.

Keywords: acute respiratory failure breathing tube mechanical ventilator
paracetamol with or without ketoprofen in the management of pain for patients receiving brachytherapy (ketocol-1304)

Conditions: Uterine Cervical Cancer; Upper Aerodigestive Tract Neoplasms

Summary: the results of the study will permit to set up a standardized and validated procedure of pain management authorizing medical and paramedical staff of brachytherapy department to handle pain and in this way to improve the quality of life of the patients.

* selection criteria validation * patient information and collection of a signed informed consent * randomization * completion of hads questionnaire * day 1 = begin of analgesic treatment / brachytherapy * t-30= 30 minutes before the operative procedure, iv administration of the analgesic treatment (arm a or b) by the anesthetist * t0= end of the operative procedure under general anesthesia * t4, t8, and t12 = 4, 8 and 12 hours after t0: evaluation of pain level. if pain level ≥ 4: 1. paracetamol-codeine (arms a and b) and continuation of ketoprofen (arm b). then, if persistence of pain : 2. paracetamol and morphine (arms a and b) * day 2 to day 30: at home or during hospital stay: pain assessment twice a day by the patient until absence of pain during 2 consecutive days * day 3 and day 15: pain assessment or phone interview by the algologist of the investigation center ; completion of a hads questionnaire on day 3 * day 30= end of study: pain assessment by the algologist of the investigation center and hads questionnaire in any case, pain assessment must be done until absence of pain during 2 consecutive days

Eligibility criteria:
inclusion criteria: * patient with a uterine cervical cancer or an upper aero-digestive tract cancer * age ≥ 18 years and ≤ 75 years * patient who are eligible for brachytherapy treatment associated with or without hospital stay * with operative procedure under general anesthesia to set up the material needed for brachytherapy * performance status ≤ 2 * creatinine clearance ≥ 60 ml/min using cockcroft equation * no coagulation disorder or anticoagulation therapy at curative dose * registered with a social security system * patient having dated and signed an informed consent form before initiation of any study procedures exclusion criteria: * respiratory pathology (spo2\< 70 %) * severe undernutrition * previous hypersensitivity reactions such as bronchospasm, asthma, rhinitis, hives or other allergic reaction to ketoprofen, to acetylsalicylic acid, or other nsaids * previous hemorrhage or gastrointestinal perforation during a previous treatment with nsaid * gastrointestinal hemorrhage , cerebrovascular hemorrhage or other evolutive hemorrhage * evolutive peptic ulcer, previous peptic ulcer or recurring hemorrhage (2 or more distinct episodes of hemorrhage or ulcer objectified) * liver insufficiency * severe renal insufficiency * severe heart failure * treatment with another nsaid, including selective cyclooxygenase-2 inhibitors * intolerance or hypersensitivity to one of the treatments or excipients * inability to swallow * pregnant or breastfeeding woman * patient under tutorship or guardianship

Keywords: pain management brachytherapy
closure of fasciotomy wounds: a prospective, observational study of a continuous external tissue expander

Conditions: Wounds and Injuries; Compartment Syndrome

Summary: fasciotomy wounds are rarely able to be closed at the time of index surgery. they often require multiple returns to surgery for closure, and occasionally require skin grafting (i.e. they are never completely closed). we are interested in seeing whether this device, which provides constant and gradual tension on the wound, may allow for rapid wound closure in a safe fashion, perhaps even precluding a return trip to surgery. null hypothesis #1: the dermaclose wound management system (woundcare technologies inc, chanhassen, minnesota) will not result in closure of fasciotomy wounds more rapidly than standard vessel loop techniques. null hypothesis #2: the dermaclose wound management system will not reduce the number of return trips to the operating room for surgical procedures related to closure or skin grafting of fasciotomy wounds.

after irb approval, all patients meeting inclusion criteria and requiring fasciotomy of the arms, legs, or pelvis will be consented for participation in the research study. patients will either have their fasciotomy wounds closed through application of the dermaclose device, as per the manufacturer's instructions, or through application of vessel loops with staples in a "shoestring technique" as described in the literature (1). choice of wound closure technique will be at surgeon discretion. all patients will undergo application of a vacuum-assisted wound closure device (wound vac, active healing solutions inc, san antonio, tx), which is standard of care for temporary coverage of open wounds (2, 3). patients will be returned to the operating room every 2-3 days until wound closure or skin grafting has been accomplished. if skin closure is not accomplished in the operating room, but occurs prior to return trip to the operating room, then definitive suture closure of the wound will be performed under local anaesthetic, followed by removal of the dermaclose device or of the vessel loop with staple shoestring. decisions regarding wound closure or skin grafting in the operating room will be left to the judgment of the attending surgeon.

Eligibility criteria:
inclusion criteria: * patients 18 years of age or older * patients undergoing fasciotomy for decompression of compartment syndrome, evolving compartment syndrome, or prophylactically to prevent compartment syndrome exclusion criteria: * patient younger than 18 years of age * patients with an active infection * patients unable to comply with protocol
ketones supplementation and postprandial lipemia

Conditions: Obesity; Overweight and Obesity; Overweight; Triglycerides High

Summary: this study determines whether different forms of ketones supplemented prior to a meal lower the triglyceride (fat) content in the blood of overweight and obese individuals. through a randomized crossover design, participants (n=15) will participate in each of the following three experimental groups (no treatment control, ketone ester, ketone salt), with a 5-14 day washout period between each experimental visit.

previous studies conducted by the investigative team in rodents show that male mice fed a diet containing 30% ketone ester (by kcals) results in greater fecal content and energy loss. while the investigators are unsure of the exact macronutrient content of the energy loss, the hypothesis is that the energy excretion is attributed to lower fat absorption. in the context of this study, it's hypothesized that ketone salts and ketone esters (both available commercially and used for a variety of health-related claims) will reduce the absorption of dietary fats leading to lower circulating triglyceride concentrations if consumed prior to a high-fat mixed meal. if the hypothesis is correct, ketones supplementation could become a valuable strategy to reduce the rise in circulating triglycerides often present in obesity. triglyceride concentrations in the blood following a meal have been linked to development of cardiovascular disease.

Eligibility criteria:
inclusion criteria: * overweight or obese men as defined by a bmi of greater than or equal to 25 kg/m2, but less than 35 kg/m2 * between the ages of 25 and 45 years * fasting triglyceride levels less than 250 mg/dl exclusion criteria: * participates in regular physical activity (≥3 days/week at 30 minutes or more per day) * diagnosed cardiovascular disease or metabolic disease (type 1 or type 2 diabetes) * currently following a low carbohydrate (\<100 g/day) diet * lost greater than or equal to 5% body weight over the last 2 months * alcohol/smoking/antibiotics
correlation of genetic polymorphisms and clinical parameters with the complexity of coronary artery disease

Conditions: Coronary Artery Disease; Cardiovascular Risk Factor; Coronary Arteriosclerosis

Summary: the purpose of the research project is to investigate the potential association of 6 genetic polymorphisms with the complexity and the severity of coronary artery disease (syntax score). the aim of the study is to combine genetic, clinical and laboratory data in order to create a prognostic tool that will enable an individualized therapeutic patient approach.

this study focus on the prediction of future risk of cardiovascular events, assessing the severity and complexity of coronary artery disease by incorporating genetic information into the syntax score and providing personalized therapeutic guidance to patients. the ultimate goal of the study would be to identify, design and develop a panel of genetic markers that in combination with clinical and angiographic information will be a reliable tool for predicting cardiovascular risk for future adverse events. clinical and genetic patient information are systematically collected in a fashion that will enable also retrospective evaluation.

Eligibility criteria:
inclusion criteria: 1. patients who are admitted in the department of cardiology in the ahepa university general hospital of thessaloniki and undergo coronary angiography for clinical purposes 2. patients giving voluntary written consent to participate in the study 3. male or female patients between 18 years to 90 years at entry 4. patients without previous history of cad exclusion criteria: 1. patients \ 90 years old at time of coronary angiography 2. patients with a previous history of cad 3. cardiac arrest at admission 4. patients with serious concurrent disease and life expectancy of \< 1 year 5. patients who refuse to give written consent for participation in the study

Keywords: syntax score coronary atherosclerosis coronary artery disease snps genetics genetic risk score personalized medicine
evaluation of topical chamomile versus topical triamcinolone acetonide in management of oral lichen planus

Conditions: Oral Lichen Planus

Summary: using of herbal medications as topical chamomile which has antioxidant, anti-inflammatory and anticarcinogenesis effect with little side effects is the aim for the future treatment of olp.

oral lichen planus (olp) is a chronic inflammatory t cell mediated autoimmune disease that affects skin and any mucous membrane particularly oral mucosa.the patient complains of burning sensation, pain; interference with eating, swallowing and speech leading to worsening of quality of life.oxidative stress plays a role in pathomechanism of olp disease. enzymatic and non- enzymatic anti-oxidants act as a physiological guard against reactive oxygen species (ros) and cytokine-mediated toxicity.herbal treatment is the aim of the future therapy.chamomile has anti-oxidant , anti-inflammatory effect and accelerate healing.

Eligibility criteria:
inclusion criteria: * symptomatic olp. * patients with no history of taking corticosteroids for the last 6 months. * patients who agree to take medication. * medically free exclusion criteria: * patients with oral lesions other than olp. * lichenoid reaction . * pregnant females and lactation. * smokers
efficacy of a mindful-eating program to reduce emotional eating

Conditions: Overweight and Obesity

Summary: mindfulness-based interventions have been applied in different fields to improve physical and psychological health. however, little is known about its applicability and effectiveness in spanish adults with overweight and obesity. the aim of the present study protocol is to evaluate the feasibility and efficacy of an adapted mbi programme to reduce emotional eating in adults with overweight and obesity in primary care (pc) settings.

this study is a multi-centre, two-armed randomized controlled trial (rct), with pre-treatment, post-treatment and 1-year follow-up measures, and a 1:1 allocation rate between groups. patients from four mental health units in zaragoza (spain) will be randomly assigned to two different parallel conditions, with one psychological intervention group ('me + tau') and usual treatment ('tau alone') managed by their general practitioner (gp), to test the superiority of 'me + tau' provision compared with 'tau alone' provision. for ethical reasons, those patients allocated to 'tau alone' will be offered the me programme after finishing the trial at 1-year follow-up.

Eligibility criteria:
inclusion criteria: * age between 45-75 years * have overweight or obesity condition based in bmi (body mass index). individuals with bmi of 25 or more. * have two of these three risk: sedentary lifestyle, poor diet and binge episodes. * ability to understand oral and written spanish. * willingness to participate in the study and signing informed consent. exclusion criteria: * any diagnosis of a disease that may affect the central nervous system (brain condition, traumatic brain injury, dementia, etc). * other psychiatric diagnoses or acute psychiatric illness (substance dependence or abuse, history of schizophrenia or other psychotic disorders, etc.), except for anxiety disorder or personality disorders. * presence of delusional ideas or hallucinations whether consistent or not with mood. * suicide risk.

Keywords: obesity overweight mindful eating primary care randomized controlled trial (rct)
effectiveness of brief mindfulness-based interventions for painful temporomandibular disorders among university students

Conditions: Temporomandibular Disorders; Chronic Pain

Summary: the goal of this clinical trial is to learn if brief mindfulness-based intervention (bmbi) is beneficial to participants suffering from painful temporomandibular disorders (tmd). the objectives of the research are: 1. to compare physical functioning (pain intensity and jaw function) in um students with chronic pain-related tmd before and after receiving bmbi 2. to compare psychological distress and mindfulness state in um students with chronic pain-related tmd before and after receiving bmbi 3. to compare the quality of life of um students with chronic pain-related tmd before and after receiving bmbi 4. to compare the changes in physical functioning, psychological distress, mindfulness state and quality of life between um students in the intervention (bmbi) and the control groups. participants will: listen to the audio recordings 3 times a week, for 3 months when they are about to sleep. make 4 visits to the clinic: baseline, 2 weeks, 1 month and 3 months later.


Eligibility criteria:
inclusion criteria: * students attending universiti malaya * able to read and understand english. * willing and able to give informed consent. * score 3 and above on the tmd-ps, for at least 3 months. exclusion criteria: * hearing impairment. * currently on psychiatric follow up and/or taking psychotropic prescriptions (antidepressants, anti-anxiety medications, stimulants, antipsychotics, and mood stabilizers). * experience with activities similar to the intervention such as meditation, yoga or tai chi. * currently practicing some form of mindfulness meditation. * history of orofacial trauma, craniofacial pathology, and previous orofacial surgeries (including orthognathic and tmj) * systemic rheumatic, neurologic/neuropathic, endocrine (e.g., diabetes mellitus) or immune / autoimmune diseases or widespread pain or being treated with immunosuppressant drugs * non-tmd orofacial pain disorders * radiation treatment to head and neck. * use of narcotic pain medication, muscle relaxants or steroid therapy unless discontinued 1 week before enrolment to study * use of nonsteroidal anti-inflammatory medications unless the medication(s) were discontinued for 3 days prior to enrolment (use of acetaminophen is allowed as a rescue drug) * currently on antibiotics or taken antibiotics within the last 2 weeks prior to start of study * currently pregnant or lactating women

Keywords: brief mindfulness-based intervention temporomandibular disorders university students