Kornimate/medical-research-clean huggingface dataset:
a trial on clinical efficacy of 1% versus 2% lignocaine in cough suppression and pain relief in patients undergoing flexible bronchoscopy

Conditions: Lung Cancer; Tuberculosis; Sarcoidosis; Interstitial Lung Disease

Summary: flexible bronchoscopy is a common procedure performed by pulmonary physicians. the use of topical anesthesia, analgesia, and sedation during flexible bronchoscopy varies among physicians, institutions and geographic locations across the globe. commonly used topical anesthetic agents before and during bronchoscopy include cocaine (4%),benzocaine (20%), tetracaine (1%), and lignocaine (1%-10%). topical lignocaine is administered through the flexible bronchoscope in an attempt to reduce excessive coughing and patient discomfort. however, the optimal dosage and strength of topical lignocaine that should be used during fibreoptic bronchoscopy has long been a topic of controversy. in this study we compare the efficacy of 1% versus 2% lignocaine in controlling cough and pain in patients undergoing flexible bronchoscopy.


Eligibility criteria:
inclusion criteria: * consecutive patients undergoing flexible bronchoscopy * hemodynamic stability exclusion criteria: * patients receiving sedatives during the course of their treatment * patients undergoing conventional tbna and/or ebus-tbna who are likely to receive sedation * patients with known hypersensitivity to lignocaine * not willing to provide informed consent

Keywords: bronchoscopy lignocaine cough
standard telephone consultation for pain

Conditions: Chronic Pain

Summary: the purpose of this study is to investigate whether pain control for patients with chronic pain is improved by the availability of structured telephone consultations between the patients' family physicians and pain physicians, compared to pain control for patients receiving usual care.


Eligibility criteria:
inclusion criteria: * patients referred to alberta health services chronic pain center in calgary with neurological or muscular skeletal pain exclusion criteria: * increased risk for suicide, very complex patients, family physician could not reliably identify patient's pain problem, or condition warranted expedited consultation with pain physician, case represented a new presentation of chronic regional pain syndrome, or low back pain with radicular symptoms or sciatica
the effect of iron deficiency anemia during pregnancy

Conditions: Iron Deficiency Anemia

Summary: iron deficiency anemia during pregnancy is a significant worldwide health problem, affecting 22% of pregnant women in industrialized countries and 52% in non-industrialized countries. iron deficiency anemia during pregnancy is associated with increased maternal as well as fetal morbidity, including prematurity, low birth-weight and perinatal and infant loss. therefore, routine iron supplementation during the second half of pregnancy has been recommended once daily. others, however, support a selective iron supplementation only for women with iron deficiency anemia, in order to avoid the increased risk of haemoconcentration associated with routine iron supplementation. unfortunately, compliance to either iron-supplementation programs, especially among pregnant women, is poor, due in part to the side effects associated with these preparations. currently, there are many iron preparations available containing different types of iron salts, including ferrous sulfate, ferrous fumarate, ferrous ascorbate but common adverse drug reactions found with these preparations are mainly gastrointestinal intolerance like nausea, vomiting, constipation, diarrhea, abdominal pain, while ferrous bis-glycinate (fully reacted chelated amino acid form of iron) rarely make complication. product resulting from the reaction of a metal ion from a soluble salt with amino acids to form coordinate covalent bonds, the resulting molecule is called as chelate and chemical bonding process is called chelation. ferrous bis-glycinate is highly stable and totally nutritionally functional chelate it is an amino acid fully reacted chelate which is formed by the binding of two molecules of glycine to one fe2+ atom.


Eligibility criteria:
inclusion criteria: 1. singleton pregnancy. 2. gestational age 14-18 weeks. 3. mild to moderate anemia 4. no associated medical or obstetric complications. 5. women not already receiving iron therapy. 6. women accepted to participate in the study. exclusion criteria: 1. multiple pregnancy 2. severe anemia 3. iron hypersensitivity. 4. liver diseases. 5. women refuse to participate in the study.
use of omics methods to classify variations of uncertain significance and improve diagnosis of neurogenetic diseases

Conditions: Neurogenetic Diseases

Summary: many neurological disorders show a strong genetic basis, from hereditary diseases caused by a single mutation in a given gene, to diseases caused by combinations of strong genetic risk factors. however, even after the sequencing of the appropriate genes, a large proportion of patients remains undiagnosed, either because there is no candidate mutation observed, or in case of identification of a candidate mutation with insufficient knowledge to consider it as pathogenic or not. the aim of this project is to identify the cause of neurogenetic diseases in patients in situations of diagnostic wandering or dead ends by proposing the analysis of rna and/or proteins from different tissues.


Eligibility criteria:
inclusion criteria: for this project, the inclusion of 3 participant profiles is required: * 1a. patient, major or minor, with a neurological disease affecting the central nervous system, who has already benefited from a genomic analysis (panel, exome or genome sequencing) as part of routine care, with inconclusive analysis because the result was either a variation of uncertain significance or the absence of a variant of interest (patients with inconclusive genomic results). * 1b. patient with neurological disease affecting the central nervous system, of confirmed monogenic or probable oligogenic cause (positive controls). * a relative of a type 1a. or 1b. patient with no symptoms of the disease, after the expected age of onset of symptoms in the patient's own family (healthy relatives). for all 3 groups: * affiliation with a social security scheme * agreement to take part in the study with signature of a specific informed consent form for the study. exclusion criteria: for patients with inconclusive results: patient with a neurological disease not suspected of a monogenic or oligogenic cause for healthy relatives: existence of a neurological disease (other than uncomplicated migraine) or psychiatric disease (other than simple anxiety stable under treatment). -

Keywords: neurogenetic diseases central nervous system disease
venetoclax registry

Conditions: Acute Myeloid Leukemia

Summary: registry study on patient characteristics, biological disease profile and clinical course in the treatment of acute myeloid leukemia with venetoclax

the aim of this study is to document all patients with aml who are treated with the bcl2 inhibitor venetoclax outside a clinical trial in all hospitals participating in this registry study in a standardised manner. data is collected retrospectively and multi-centric. it is neither a therapy study nor is the therapy influenced by this study. 1. systematic and uniform collection and documentation of all patients treated with the bcl2 inhibitor venetoclax. 2. collection and integrative analysis of clinical data of included patients. 3. mutation analysis of available patient samples and correlation with clinical parameters.

Eligibility criteria:
inclusion criteria: relapsed/refractory aml exclusion criteria: -

Keywords: relapsed/refractory adult acute myeloid leukemia (aml)
pd-1 blockade combined with definitive chemoradiation in locoregionally-advanced nasopharyngeal carcinoma

Conditions: Nasopharyngeal Neoplasms

Summary: this trial plans to enroll 40 patients with stage iii-iva (ajcc 8th, except t3n0-1 or t4n0) locoregionally-advanced nasopharyngeal carcinoma (npc). patients will receive 3 cycles of induction chemotherapy with gemcitabine and cisplatin and concurrent cisplatin-radiation. all patients will receive intensity-modulated radiotherapy (imrt). sintilimab will begin on day 1 of induction chemotherapy and continue every 3 weeks for 6 cycles.


Eligibility criteria:
inclusion criteria: 1. patients with histologically confirmed nasopharyngeal carcinoma. 2. tumor staged as iii-iva (ajcc 8th, except t3n0-1 or t4n0). 3. ecog performance status ≤1. 4. adequate marrow function: neutrocyte count≥1.5×10e9/l, hemoglobin ≥90g/l and platelet count ≥100×10e9/l. 5. alanine aminotransferase (alt)/aspartate aminotransferase (ast) ≤2.5×upper limit of normal (uln), and bilirubin ≤ 1.5×uln. 6. adequate renal function: creatinine clearance rate ≥ 60 ml/min (cockcroft-gault formula). 7. patients must be informed of the investigational nature of this study and give written informed consent. 8. women of childbearing potential (wocbp) who are sexually active must be willing to adhere to effective contraception during treatment and for 1 year after the last dose of study drug. men who are sexually active with wocbp must be willing to adhere to effective contraception during treatment and for 1 year after the last dose of the study drug. exclusion criteria: 1. age \> 65 or \< 18. 2. hepatitis b surface antigen (hbsag) positive and hbv dna \>1×10e3 copies/ml 3. hepatitis c virus (hcv) antibody positive 4. has active autoimmune disease, except type i diabetes, hypothyroidism treated with replacement therapy, and skin disease that doesn't require systemic treatment (e.g., vitiligo, psoriasis, or alopecia). 5. has a known history of interstitial lung disease. 6. has any condition that required systemic corticosteroid (equivalent to prednisone \>10mg/d) or other immunosuppressive therapy within 28 days before informed consent. patients received systemic corticosteroid equivalent to prednisone ≤10mg/d, inhale or topical corticosteroid will be allowed. 7. has received a live vaccine within 30 days before informed consent or will receive a live vaccine in the near future. 8. is pregnant or breastfeeding. 9. prior malignancy within 5 years, except in situ cancer, adequately treated non-melanoma skin cancer, and papillary thyroid carcinoma. 10. has known allergy to large molecule protein products or any compound of sintilimab. 11. has a known history of human immunodeficiency virus (hiv) infection. 12. any other condition, including symptomatic heart failure, unstable angina, myocardial infarction, active infection requiring systemic therapy, mental illness or domestic/social factors, deemed by the investigator to be likely to interfere with a patient's ability to sign informed consent, cooperate and participate in the study, or interferes with the interpretation of the results.
handle-a real world study on satralizumab in nmosd

Conditions: Neuromyelitis Optica Spectrum Disorders (NMOSD)

Summary: this study is a single-center, retrospective-prospective, non-interventional cohort study to assess the clinical outcomes of chinese nmosd patients treated with satralizumab in a real-world patient management model by collecting follow-up data in clinical practice.


Eligibility criteria:
inclusion criteria: 1. patients have been diagnosed with nmosd and tested seropositive for aqp4 antibody, ≥ 12 years old; 2. edss score ≤ 8.5 at baseline; 3. patients have experienced ≥ 1 relapse of nmosd in the last 12 months or ≥ 2 relapses in the last 24 months; 4. patients should have received or be anticipated to receive satralizumab treatment for at least 12 months; 5. patients understand the study procedures and sign the informed consent form indicating willingness to participate in the study (for those \< 18 years of age, the guardian should sign the informed consent form on behalf of the patient). exclusion criteria: -
status telemetry for cochlear implantations

Conditions: Sensorineural Hearing Loss

Summary: cochlear implants (cis) are well-established neuroprosthesis used to restore hearing for patients with partial or complete deafness. however, the audiological outcomes of these implants can vary widely, and one reason for this is suboptimal electrode placement. the gold standard for measuring electrode positions is computed tomography (ct) scans, but they are expensive and expose patients to additional radiation, which is especially harmful for children. this study investigates an alternative approach using impedance telemetry data to estimate electrode positions without exposing patients to radiation. for this purpose, an extended telemetry version of a ce-certified cochlear implant software is used. the advanced impedance telemetry software can measure impedance subcomponents with improved measurement resolution that could be used for more accurate estimation of electrode insertion depth using specially designed estimation software. ultimately, the investigators want to demonstrate the potential to improve audiological outcomes of cochlear implant recipients without exposing them to additional radiation.


Eligibility criteria:
inclusion criteria: * informed consent signed by the subject * subjects scheduled for ci surgery according to clinical routine * subjects who will receive a cochlear implant of the med-el portfolio (flex series arrays) * no radiological contraindications * stated willingness to comply with all study procedures for the duration of the study exclusion criteria: * lack of compliance with any inclusion criteria * subjects incapable of giving informed consent * age under 18 years * pregnancy
effect of three modalities of spontaneous breathing tests on respiratory efforts in tracheostomized patients

Conditions: Mechanical Ventilation Complication

Summary: datas are lacking concerning weaning from mechanical ventilation for tracheostomized patients. in particular, the effect of different modalities of spontaneous breathing trials on respiratory effort has not been extensively described. this crossover physiology study will include 18 tracheostomized patients ventilated for more than 72 hours. the objective of this study is to compare the effect of three different modalities of sbts on respiratory effort in tracheostomized patients. the modalities tested are : pressure support ventilation (psv level 5 cmh2o, peep 5 cmh2o), t-piece test and high-flow oxygen. each modality is applied in a randomized order, during 30 minutes. during every modality tested, esophageal and gastric pressure, expired co2, and comfort will be monitored, in addition to standard monitoring. based on esophageal pressure monitoring, patient's respiratory efforts can be calculated either by esophageal pressure-time product and work of breathing. pressure generated by inspiratory muscles will also be assessed.


Eligibility criteria:
inclusion criteria: * patients for whom a tracheostomy is planned * patients on invasive ventilation for \>72 hours exclusion criteria: * tracheostomy for upper airway obstruction or other disease * patients tracheostomized before current hospitalization * patients with glasgow coma scale (gcs) \< 8/10 after cardiac arrest * patients with gcs \< 8/10 because of primary central neurologic disease * patients for whom therapeutic limitations have already been decided * patients for whom weaning from ventilation is not an objective * patients suffering from myasthenia gravis * patients with cardiac assistance device * patients with medullary lesion proximal to c5 * patients for whom nasogastric tube insertion is contraindicated

Keywords: ventilation tracheotomy difficult weaning spontaneous breathing test esophageal pressure work of breathing esophageal pressure time-product difficult weaning from mechanical ventilation ventilation weaning
personality change during medical residency

Conditions: Personality; Coping Skills

Summary: the ethics committee of hospital and university center of coimbra (portugal) complies, reports and is supervisioned by the portuguese ethics committee. the ethics committee of hospital and university center of coimbra is an multidisciplinary organ of ethics experts that give support to the board of hospital directors, the health personnel and patients, regarding bioethical issues emerging from clinical assistance activities (addressed to patient's health being, education and clinical research).


Eligibility criteria:
inclusion criteria: * medical residents with ages between 23 and 45 years old, attending the first year of medical specialty in portugal in the following specialties\*: general surgery, neurosurgery; orthopedics; intern medicine, gastroenterology; cardiology; rheumatology; endocrinology; oncology; intensive medicine; pediatric; radiology; clinical pathology; neurology and psychiatry. * acceptance and commitment to participate in the study. * signature of study' informed consent. exclusion criteria: * attendance, during the study, in an international formative stage with a duration superior to 12 months. * previous attendance of other medical specialty for more than one year. * present or past history of major psychiatry disorders (illicit drug abuse with dependence, schizophrenia, bipolar disorder or schizoaffective disorder)

Keywords: personality change perfectionism coping medical specialty medical residency
an exploratory investigation of a supplement to promote brain health

Conditions: Memory Deficits; Cognitive Change; Stress

Summary: providing a combination of synergistic dietary supplements, such as vitamins b6, b12, and folate, as well as curcumin, lemon balm, and american ginseng is hypothesized to promote brain health and aid with brain fog, mental clarity, ability to handle stress, mood, focus, and productivity, as well as promote overall well-being.


Eligibility criteria:
inclusion criteria: * in good general health with no major chronic conditions (e.g., diabetes, coronary heart disease, etc.) exclusion criteria: * females who are pregnant or breastfeeding * anyone currently taking other supplements * anyone with a known allergic reaction * previous head trauma * anyone with chronic diseases such as diabetes, coronary heart disease, or cancer. * any psychological, mental, or neurodevelopmental disorders * consumes nicotine or marijuana in any form * previous or current alcohol addiction * consume more than 10 drinks per week

Keywords: focus memory attention stress
exercise application in the treatment of patients with subacromial pain syndrome

Conditions: Shoulder Impingement Syndrome

Summary: this study evaluate the effectiveness of adding neuromuscular exercises with tactile, visual and auditory feedback to a scapula-focused treatment, both emphasizing the periscapular muscles on improvement of disability in patients with subacromial pain syndrome compared to patients receiving only strengthening exercise protocol.

evidence of the effectiveness conservative treatments in shoulder impingement are in favor the application of specific exercises for scapulothoracic muscles and rotator cuff on pain reduction and improvement of upper limb function, supervised or performed at home, and these same exercises associated with other therapies promote a greater reduction in pain and improvement in disability. currently, the evidence of better methodological quality present in the literature13 points out that the performance of motor control exercises focused on the scapula associated with mobilization and stretching generate pain improvement and clinically relevant improvement of the function. the few studies in this area have great methodological diversity with significant limitations. the hypothesis is that patients with subacromial pain syndrome who will receive traditional exercise protocol with the addition of neuromuscular training will show less functional disability, a greater reduction in pain intensity, increase muscle strength and range of motion when compared to the patient group that will receive only the protocol without neuromuscular training, immediately after the intervention, four and eight weeks and four months after randomization and that these benefits are clinically relevant.

Eligibility criteria:
inclusion criteria: * diagnosis of subacromial pain syndrome with confirmed positivity in at least three of the five specific orthopedic impact tests: neer test, hawkins- kennedy test, painful arc, external rotation resistance and empty can. present history of pain in the shoulder lasting more than a week located in the proximal area of the shoulder exclusion criteria: * subjects with a history of trauma or shoulder surgery, total rupture of the rotator cuff tendon and biceps, physically active involving the upper limbs or considered active accordance with the short version international physical activity questionnaire (ipaq). subjects who have neurological diseases, referred pain in arms (indicative of involvement in the cervical or thoracic region), systemic disease involving the joints such as rheumatoid arthritis or fibromyalgia, the presence of disorders in the wrist such as carpal tunnel syndrome, and have done physical therapy in the shoulder the last six months.

Keywords: rehabilitation shoulder
super skills for life effectiveness in clinical settings

Conditions: Depressive Disorder; Depressive Symptoms; Trauma and Stressor Related Disorders; Anxiety Disorders and Symptoms; Anxiety Disorders; Mood Disorders; Emotional Disorder

Summary: super skills for life (ssl) is a transdiagnostic cognitive-behavioral protocol developed for children aged 6 to 12 with anxiety and comorbid problems (e.g., depression, low self-esteem, and lack of social skills). ssl consists of eight sessions targeting common risk factors for internalizing disorders such as cognitive distortions, avoidance, emotional management, low self-esteem, social skills deficits and coping strategies. the aim of the study is to investigate the short- and long-term effects of ssl on internalizing and externalizing symptoms in spanish children attending the child and adolescent mental health services.

to validate eligibility children and their parents will complete several psychometrically robust and developmentally appropriate measures. participants meeting inclusion criteria will be randomly allocated to the conditions of the intervention group and the wait-list control group. parents and children from both groups will complete the same measures at baseline and post-treatment. parents and children from ssl will also complete these measures at 3 months follow-up, 6 months follow-up and 12 months follow-up. the investigators will assess the benefits from pre-test to post-test in children participating in ssl compared to those in a wait-list control group on dsm-5 diagnostic remission, anxiety symptoms, anxiety impairment, depressive symptoms, self-esteem, behavioral problems, hyperactivity/inattention, peer relationship problems, and prosocial behavior. the investigators will also assess these variables in the intervention group at 3 months, 6 months, and 12 months follow-up. ultimately, the goal of the study is to explore whether ssl can be a cost-effective psychological intervention for emotional disorders in the spanish national health system.

Eligibility criteria:
inclusion criteria: * children aged 8 - 12. * primary diagnosis of an anxiety disorder, a depressive disorder, and/or trauma- or stress-related disorder with anxiety and/or depressive symptoms. * speaking, reading, writing and understanding spanish. * caregivers agree to attend all sessions and to receive feedback and suggestions. exclusion criteria: * intellectual disability, behavioral symptoms, or autism spectrum symptoms whose severity precluded continued treatment. * the child is at the same time in psychological treatment. * the child is not on a stable dose of medication for at least 1 month prior to baseline assessment.