Kornimate/medical-research-clean huggingface dataset:
order effects of prematurity outcome data

Conditions: Premature Birth

Summary: women recruited from the internet were put in a hypothetical situation of being in labor at 22 weeks of pregnancy, and presented with information in the form of pictographs about survival and disability of babies born at this gestational age. participants were randomized to receive these pictographs in a different order (survival or disability first) and to receive descriptiveness level of survival (just numerical information, or also description of course of nicu stay). participants were then asked to choose between comfort care and intensive care in this situation. participants' religiosity, value of the sanctity of life, and health literacy were also assessed.

the national institute of child health and human development (nichd) workshop on periviable birth recommended that information on the chance of survival and risk of disability should be provided separately. the order in which information is presented can affect memory, persuasiveness, and treatment choice, but the effect of order of information presentation in the context of neonatal resuscitation has received little attention. additionally, the effect of including a description of the long and intense time in the neonatal intensive care unit (nicu) on parental treatment decision making is also unexplored. current evidence suggests that pictographs best convey numerical information to parents. three pictographs were developed based on nichd data for 22 weeks gestational age (ga) babies who received intensive care. one pictograph displayed information on the rates of disability in the babies who survive. two pictographs displayed information about how many babies born at 22 weeks survive, with one of these pictographs including a description of the average course of nicu stay. an internet survey was sent to a u.s. representative sample of women of child-bearing age. a vignette including background on prematurity and the treatment options of intensive care or comfort care for a baby born at 22 weeks ga was presented. participants viewed the pictographs, evenly randomized to one of four experimental conditions (order of information presentation x level of description of nicu course). participants were then asked to choose intensive care or comfort care. participant religiosity, values (quality vs. sanctity of life), autonomy preferences in medical decision making, previous nicu exposure, numeracy, and health literacy were also assessed.

Eligibility criteria:
inclusion criteria: * women of childbearing age (defined as 18-50) living in the u.s. exclusion criteria: * minors, those unable to read english, and those who only could complete the survey on their phone. (for formatting purposes, a tablet or computer was necessary.)

Keywords: decision making neonatal resuscitation order effect prenatal counseling
stripping massage after thoracoscopy

Conditions: Chest Pain

Summary: this study investigated the effects of stripping massage (sm) on myofascial trigger points in the rhomboid after thoracoscopic surgery.

this study investigated the effects of stripping massage (sm) on myofascial trigger points in the rhomboid after thoracoscopic surgery. sixty patients with chest pain after thoracoscopic surgery were randomized divided into two equal groups (a and b). group a (n = 100) received conventional analgesics. group b (n = 100) received sm twice daily in the active trigger points of the rhomboid for two weeks. the visual analogue scale, a pressure algometer, will be used to evaluate patients' pre- and post-treatment statuses. this study will compare differences between the current traditional method (using analgesics) and the sm for rhomboid myofascial trigger points for post-thoracoscopic chest pain, and analyze the variables generated by the two different methods including demand time of analgesics, acceptance, and differences of visual analogue scale. the results of the study will use scientific data to prove which way is a good way to take into account of the relief of patient's chest pain.

Eligibility criteria:
inclusion criteria: * chest pain with visual analogue scale larger than 3 after thoracoscopic surgery exclusion criteria: * bleeding tendency

Keywords: chest pain; stripping massage; thoracoscopy; trigger points
mindful awareness in body-oriented therapy for women's substance abuse treatment

Conditions: Substance Use Disorder

Summary: the primary purpose of this exploratory and developmental study is to evaluate a mind-body intervention for relapse prevention for women in addiction treatment. the proposed intervention, mindful awareness in body-oriented therapy (mabt), is a novel mind-body intervention designed to enhance embodiment and to facilitate mindfulness through the combination of massage, body awareness exercises and the acquisition of mindfulness skills. the treatment goals of mabt include reduction of avoidant coping responses, increase of emotional-regulation, and decrease of trauma symptoms through access to and acceptance (vs. avoidance) of sensory and emotional experience. these are thought to be important for relapse prevention given the positive association between stress, negative affect and relapse; and risk of relapse associated with ptsd symptoms. mind-body interventions in relapse prevention are of increased clinical and scientific interest, particularly for the potential to overcome automatic response patterns that are associated with lapse and relapse in substance use treatment. this proposal falls within the current nida research portfolio focus on the development of interventions that will help people better cope with stress, negative affect, and trauma. specific aims: * aim 1: to examine feasibility of recruitment to and retention in mabt as an adjunct to substance abuse treatment. specifically, to describe a) study enrollment and barriers to recruitment, b) sample characteristics, c) response to randomization, d) session attendance, and e) loss to follow-up. * aim 2: to describe mabt acceptability to study participants and substance abuse treatment staff. * aim 3: to compare the effect of body-oriented therapy plus treatment-as-usual vs. treatment-as-usual only on reported days abstinent for overall substance use and primary drug use among women receiving substance abuse treatment, in order to estimate the effect size. secondary analyses will examine for intervention effects on related outcomes including days abstinence on biochemical screens for substance use, body connection indicators, avoidant coping, stress reactivity, co-morbid psychological distress, and physical well-being.


Eligibility criteria:
inclusion criteria: * female * enrolled in weeks 1-3 of residence xii inpatient program * plans continued out-patient treatment at residence xii * willing to sign release to contact the residence xii mental health therapist in the case of concern regarding participant safety and well being * willing to forgo (non-study) body therapy between baseline and post-intervention assessment (3 months) * willing to accept random assignment to study treatment conditions exclusion criteria: * current domestic violence * pregnant
improvement in quality of life and pain scores after laparoscopic management of deep infiltrating endometriosis

Conditions: Endometriosis

Summary: this is a retrospective cohort study that evaluates the postoperative pain findings of a consecutive series of laparoscopic surgeries for deep infiltrating endometriosis (die).

the study was carried out in university hospitals (istanbul, turkey). patients diagnosed through bimanual gynecologic examination, gynecologic ultrasound or magnetic resonance imaging-confirmed endometrioma and die together; who underwent a laparoscopic surgery by a team of gynecologists, colorectal surgeons, and a urologist were retrospectively evaluated. the data were collected in a specific database and analyzed for postoperative pain outcomes through a comparison with preoperative symptoms scored using a visual analogue score (vas), and the british society of gynecologic endoscopy (bsge) pelvic pain questionnaire.

Eligibility criteria:
inclusion criteria: * patients with deep infiltration endometriosis and endometrioma diagnosed through bimanual gynecologic examination, gynecologic ultrasound or through laparoscopically confirmed endometrioma and die together; * die with bowel involvement that required shaving or segmental resection for colorectal lesions and nodules; * who completed the vas score and bsge questionnaire; * follow-up period of at least 3 months; * patients resistant to medical therapy (nsaids, ocps, levonorgestrel-releasing intrauterine device (iud), and progesterone) or refuse to use medical therapy. exclusion criteria: \*any other endometriosis patient that do no meet the inclusion criteria

Keywords: endometriosis
localisation of potential insulin deposits in normal weight and obese diabetics using 6 mm and 12 mm long needles

Conditions: Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Delivery Systems

Summary: this trial is conducted in europe. the primary aim of this clinical trial is to locate and compare simulated insulin injections (injections of sterile atmospheric air) in normal weight and obese patients with diabetes mellitus. injections are done with 6 mm and 12 mm needles with and without lifting of skin fold at different injection sites.


Eligibility criteria:
inclusion criteria: * diabetes mellitus * use novopen®, novopen® 1.5, novopen® 3, novolet® 1.5 or novolet® 3 for at least 3 months * body mass index (bmi) for normal weight between 19-25 kg/m2 * body mass index (bmi) for obese between 25-33 kg/m2 exclusion criteria: * pregnancy or plans thereof * local reactions on injection sites * acute, severe infection diseases * coagulation disorders
post-exposure prophylaxis in health care workers

Conditions: Human Immunodeficiency Virus

Summary: objective: the objective of this study is to determine the safety and tolerability of post-exposure prophylaxis (pep) with a regimen of truvada + kaletra among health care workers (hcws) at henry ford hospital. hypothesis: raltegravir is safe and better tolerated compared with kaletra, each in combination with truvada, as assessed by review of completion rates of pep and also review of completed safety data.

health care workers that have occupational exposure to blood are at risk for hiv infection. prevention of blood exposure, through safer practices, barrier precautions, safer needle devices, and other innovations, is the best way to prevent infection with hiv and other bloodborne pathogens. though these strategies have been successful in reducing the frequency of blood exposure and needlestick injuries in the past decade, the hazard has not been eliminated. as of december 2001, the cdc had received voluntary reports of 57 documented cases of hiv seroconversion temporally associated with occupational exposure to hiv among u.s. health care personnel. an additional 138 infections among health care personnel were considered possible cases of occupational transmission. because there is no cure or effective vaccine for hiv, optimal post exposure care, including the administration of antiretroviral drugs to prevent hiv infection, remains a high priority in protecting health care workers.

Eligibility criteria:
inclusion criteria: * adult (at least 18 years of age)employees of hfh * history of occupational exposure to bodily fluids * negative hiv test * the ability to understand a written informed consent form, which must be obtained prior to initiation of any study procedures exclusion criteria: * positive pregnancy test * females who are breastfeeding * history of renal disease * contraindication for treating patient with components of pep regimen * greater than one dose of pep medication for this exposure event

Keywords: post exposure prophylaxis health care workers
the objective is to evaluate the anterior chamber angle after bang procedure, the study will recruit 12 patients who will undergo planned goniectomy for uncontrolled poag, anterior segment oct scan will be used to evaluate the anterior chamber postoperatively.

Conditions: Primary Open Angle Glaucoma; Glaucoma

Summary: evaluation of anterior segment using anterior segment optical coherence tomography in patients undergoing planned bent angle needle goniectomy procedure for uncontrolled open angle glaucoma.


Eligibility criteria:
inclusion criteria: 1. patients who are being treated for primary open angle glaucoma using eye drops. 2. patients with uncontrolled intraocular pressure \&gt;21 mm hg 3. all recruited patients should have open anterior chamber angles demonstrated on gonioscopy examination. 4. patients giving consent for operation and follow up exclusion criteria: * 1- pseudophakic patients 2- advanced glaucoma patients. 3- patients who are to have trabeculectomy or laser trabeculoplasty. 4- patients with secondary glaucoma. 5- patients who are unable to give consent for surgery or follow up. 6- patients with previous trauma to the eye

Keywords: bent angle needle goniectomy anterior segment optical coherence tomography primary open angle glaucoma
left atrial appendage closure during open heart surgery

Conditions: Atrial Fibrillation; Cerebral Embolism; Stroke

Summary: because atrial fibrillation occurs frequently in heart surgery patients, our overall hypothesis is that systematic closing the left atrial appendage during surgery will reduce cerebral embolism coming from the thrombus formation in the left atrium. the specific hypothesis which sought tested is that closure of the left atrial appendage in connection with elective cabg and / or valve surgery will lead to fewer strokes and micro cerebral infarcts measured by mri.

patients are included prior to surgery. an mri is performed at baseline. at the day of surgery, patients is randomized to closure/left open left atrial appendage. during surgery, a maximum of 15 ml blood and a right atrium biopsy are taken for further analyses. additionally, a biopsy of the left atrium appendage is collected from the group of patients randomized for closure. the study group recommend a double closure. after discharge a second mri is performed and the final mri is performed after a minimum of six months. the final contact with the patient is done one year after surgery at the earliest. where a clinical interview is done over the phone and the patients clinical records are screened for cerebral ischaemic events and atrial fibrillation. during the study period, some patients are elected for a bicycle stress test to test for levels of neurohormones, and some are elected for monitoring with holter. there will also be performed transesophageal echocardiography on interested patients in order to test for the quality of surgical closure.

Eligibility criteria:
inclusion criteria: * age \> 18 years old. * elective open heart surgery by-pass (cabg) and/or valve surgery * signed informed consent exclusion criteria: * off pump heart surgery * endocarditis * patients with metal implants not suitable for mri * patients with planned implantation of pacemaker after surgery
comparing ftc and lamivudine in hiv-infected patients on a stable anti-hiv drug combination

Conditions: HIV Infections

Summary: the purpose of this study is to compare two anti-hiv drugs, ftc and lamivudine (3tc), when given with either stavudine (d4t) or zidovudine (zdv) and one other anti-hiv drug.

patients are randomized to one of two arms in a 2:1 ratio (weighted to arm 1). arm 1: replace lamivudine with ftc while continuing on current background regimen. arm 2: continue on current lamivudine-containing regimen. patients are further stratified based upon screening plasma hiv-1 rna and background therapy. stratum 1: less than 50 copies/ml; pi (protease inhibitor) in treatment regimen. stratum 2: less than 50 copies/ml; nnrti (nonnucleoside reverse transcriptase inhibitor) in treatment regimen. stratum 3: 50-400 copies/ml; pi in treatment regimen. stratum 4: 50-400 copies/ml; nnrti in treatment regimen. clinic visits occur at regular intervals throughout the 48-week study period to determine viral load.

Eligibility criteria:
inclusion criteria you may be eligible for this study if you: * are at least 18 years old. * are hiv-positive. * have a viral load below 400 copies/ml. * agree to use a barrier method of birth control (such as condoms) during the study. * have taken one of the following anti-hiv drug combinations: (1) 3tc plus d4t or zdv plus a protease inhibitor (pi) for at least 8 weeks, or (2) 3tc plus d4t or zdv plus a nonnucleoside reverse transcriptase inhibitor (nnrti) for at least 12 weeks. (you must show the date you started on this combination.) exclusion criteria you will not be eligible for this study if you: * have had severe diarrhea or have been unable to eat as much as you need due to nausea, vomiting, or stomachache within 30 days of study entry. * have had a serious medical event within 30 days prior to study entry. * are taking hydroxyurea. * have grade 2 or higher peripheral neuropathy. * abuse alcohol or drugs. * are pregnant or breast-feeding.

Keywords: hiv-1 zalcitabine zidovudine stavudine hiv protease inhibitors lamivudine rna, viral reverse transcriptase inhibitors anti-hiv agents
effects of crestor on inflammation of atherosclerotic plaques

Conditions: Atherosclerosis; Inflammatory Activity in Carotid Arteries

Summary: the primary aim of this study is to investigate the effect of 40 mg dose of rosuvastatin on carotid plaque inflammation measured with mri and pet scanning, to evaluate whether these techniques are promising for future proof of principle studies. a number of patients will receive placebo as a control.


Eligibility criteria:
inclusion criteria: * subjects with a non-calcified plaque of at least 2 mm over an at least 6 mm length on first mr scan with an uptake of contrast agent on the dynamic mri scan * signed written informed consent. * healthy men 18 - 70 years, women 60 - 70 exclusion criteria: * use of a statin within six months before randomization. * use of lipid altering medication other than statins within the last six months. * clinical evidence of metabolic or vascular disease requiring statin or other lipid lowering pharmacological or non-pharmacological treatment. * total cholesterol \> 8, ldl-c \> 6 or tg \> 6 mmol/l at enrolment

Keywords: imaging biomarkers mri fdg-pet/ct scanning crestor
resistance exercise training in chronic kidney disease

Conditions: Chronic Kidney Disease

Summary: the investigators aim to evaluate the feasibility of a resistance exercise training program among individuals with ckd and its impact on endothelial and vascular function.

resistance exercise training has been shown to improve cardiovascular health including endothelial function in general populations, but studies in patients with chronic kidney disease (ckd) are limited. the investigators aim to evaluate the feasibility and acceptability of a resistance exercise training program among individuals with ckd and its impact on endothelial and vascular function as measured by brachial artery flow-mediated dilation, pulse-wave velocity and carotid artery stiffness. to accomplish this goal the investigators propose to conduct a 12-week pilot randomized controlled trial of twice a week resistance exercise training among 32 adults with ckd. the results of this study will inform the design and implementation of a larger trial evaluating the impact of resistance exercise training on adverse outcomes in patients with ckd including ckd progression.

Eligibility criteria:
inclusion criteria: * ckd stage 3 or 4 (egfr 15-60 ml/min/1.73m2) exclusion criteria: * currently institutionalized * kidney transplant or dialysis * ny heart association class 3-4 heart failure * dementia or cognitive impairment * unstable angina or coronary revascularization within the last 3 months * uncontrolled arrhythmia * severe chronic lung disease * orthopedic, neurologic or other condition that would preclude resistance exercise training * pregnancy * uncontrolled hypertension (systolic \> 160 mmhg and diastolic \>90 mmhg)
extralevator versus standard abdominoperineal resection for rectal adenocarcinoma

Conditions: Rectal Adenocarcinoma

Summary: this is a study that compares two types of surgery for rectal cancer. there are two procedures that can be used during this surgery, conventional abdominal resection (apr) and extended (or extralevator) apr. the investigators are doing this research to see whether the extralevator apr increases the likelihood that the edge of the tissue that is removed will be more likely to be free from cancer cells compared with the conventional apr surgery. at this time there is no evidence that one type of procedure is better at this than the other. the objective of this research is to determine whether extralevator apr is more likely to have clean margins (free of cancer) compared to the standard apr surgery.


Eligibility criteria:
inclusion criteria: * resectable, histologically proven primary adenocarcinoma of the low rectum with internal and/or external sphincter muscle involvement. staged as follows prior to neoadjuvant chemoradiation: * stage t3 or t4 at mri * n0-2 at mri * m0 at ct scan * patient must undergo long term neoadjuvant chemoradiation: 20 fractions of radiation over ≥5 weeks: total of 50-60 gy, and chemotherapeutic agents exclusion criteria: * squamous cell carcinoma * adenocarcinoma stage t1-2, any n * t4 with one of the following: with pelvic side wall involvement requiring sacrectomy requiring prostatectomy (partial or total) distant metastasis (m1) unresectable primary rectal cancer or inability to complete r0 resection. recurrent rectal cancer previous pelvic malignancy inability to sign informed consent pregnancy

Keywords: rectal adenocarcinoma standard apr extralevator apr
a study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of aln-ttrsc04 in healthy subjects

Conditions: Transthyretin-Mediated Amyloidosis

Summary: the purpose of this study is to evaluate the safety, tolerability, pharmacodynamics (pd) and pharmacokinetics (pk) of single ascending doses of aln-ttrsc04.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) ≥18.0 kg/m\^2 and ≤30 kg/m\^2 assessed at screening. exclusion criteria: * has an estimated glomerular filtration rate (egfr) \<90 ml/min/1.73m\^2 at screening. * has alanine aminotransferase (alt), aspartate aminotransferase (ast) or direct bilirubin above the upper limit of normal (uln).

Keywords: attr amyloidosis sirna
periodic limb movements among dialysis and non-dialysis chronic kidney disease patients

Conditions: The Aim of the Study Was to Screen Prevalence of Periodic Limb Movements Among Chronic Kidney Disease Patients

Summary: periodic leg movement disorder is defined as periodic episodes of repetitive limb movements during sleep that mainly occur in the lower limb, including the hips, knees and toes and sometimes affects the upper limb. it may be accompanied by frequent nocturnal arousals, and if so, this sleep disturbance may cause excessive daytime sleepiness. chronic kidney disease patients are at risk of periodic leg movements and common causes are iron deficiency, anemia, raised serum calcium and central and peripheral nervous system disorders.


Eligibility criteria:
inclusion criteria: * chronic kidney disease exclusion criteria: * diabetic, hepatic and chrest disease patients