Kornimate/medical-research-clean huggingface dataset:
effects of gong's versus mulligan mobilization in patients with adhesive capsulitis

Conditions: Adhesive Capsulitis of Shoulder

Summary: a randomized clinical trial will be conducted at dhq hospital kasur,bit hospital kasur,arif memorial hospital lahore.pre-diagnosed patients will be reassessed by applying (shoulder shrug sign, hand to neck, hand to scapula, hand to opposite scapula,hand to back,capsular pattern movement restriction)plus all other special tests will be applied to confirm that symptoms are not due to other shoulder pathologies but are due to just adhesive capsulitis then through consecutive sampling technique on 60 patients they will be allocated using computer generated sampling(random number table) into group a and group b.

a randomized clinical trial will be conducted at dhq hospital kasur,bit hospital kasur,arif memorial hospital lahore.pre-diagnosed patients will be reassessed by applying (shoulder shrug sign, hand to neck, hand to scapula, hand to opposite scapula,hand to back,capsular pattern movement restriction)plus all other special tests will be applied to confirm that symptoms are not due to other shoulder pathologies but are due to just adhesive capsulitis then through consecutive sampling technique on 60 patients they will be allocated using computer generated sampling(random number table) into group a and group b. group a will be treated with gong's mobilization and group b will be treated with mulligan mwm the procedures will be performed three sets of 10 repetitions, with 1 minute rest between sets,thrice per week for a total of six weeks. pre and post intervention values will be taken on 1st day and after 6 weeks. outcome measures will be conducted through vas for pain,spadi for functional disability , goniometer for range of motion ,sf-36 for quality of life after 6 weeks. data will be analyzed during spss software version 25. after assessing normality of data by shapiro-wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.

Eligibility criteria:
inclusion criteria: * age 40 to 50 years * both male and female * pre-diagnosed unilateral primary frozen shoulder patients * prediagnosed stage 3(frozen phase) patients(27) exclusion criteria: * patients with previous surgery in the shoulder joint * history of recent fracture or severe trauma to the shoulder * diagnosed instability or previous history of dislocation * systemic inflammatory conditions(e.g.rheumatoid arthritis)

Keywords: adhesive capsulitis functional disability range of motion
efficacy of quantum molecular resonance combined with intense pulsed light in mixed dry eye

Conditions: Dry Eye

Summary: this study examines the effectiveness of combining quantum molecular resonance (qmr) and intense pulsed light (ipl) treatments for mixed dry eye, a condition where both tear production and tear quality are compromised. twenty-five patients received both treatments over a period of six weeks, and their symptoms and tear quality were monitored for three months.

study title: efficacy of quantum molecular resonance combined with intense pulsed light in mixed dry eye: a prospective clinical study purpose of the study: this study aims to evaluate how well two treatments-quantum molecular resonance (qmr) and intense pulsed light (ipl)-work when used together to treat mixed dry eye (mde). mixed dry eye is a condition that affects both the quantity and quality of tears, leading to discomfort and vision problems. the goal is to see if combining these treatments can better relieve symptoms and improve tear production and stability. what is mixed dry eye? dry eye disease is a common condition that can cause symptoms like burning, itching, and blurred vision. mixed dry eye occurs when both the tear production is low, and the tears evaporate too quickly, leading to chronic discomfort. what are qmr and ipl treatments? qmr (quantum molecular resonance): this is a newer technology that uses low-intensity, high-frequency waves to stimulate the cells in the eye. it may help improve tear production and reduce inflammation. ipl (intense pulsed light): this treatment uses light to heat the skin around the eyes, which helps improve the function of glands that produce the oily layer of tears, preventing tears from evaporating too quickly. study design: participants: 25 patients with mixed dry eye treatment: participants received 4 sessions of qmr and 3 sessions of ipl over 6 weeks. they were also given tear substitutes to use during the study. follow-up: patients were evaluated at the beginning, and after 1 and 3 months to assess the improvement in their condition.

Eligibility criteria:
inclusion criteria: * age 18 years or older * diagnosed with mixed dry eye (mde) * ocular surface disease index (osdi) score of 13 or higher * non-invasive tear film break-up time (nibut) less than 10 seconds * lipid layer thickness (llt) less than 75 nm * schirmer i test (st) without anesthesia less than 5 mm in 5 minutes exclusion criteria: * presence of skin conditions that prevent qmr or ipl treatments * corneal disorders that affect diagnostic tests, including: * active corneal infections * corneal dystrophies * active ocular allergy * previous device-based dry eye treatments, such as: * microblepharoexfoliation * low-level light therapy * vectored thermal pulsation * inability to understand or comprehend the informed consent * pregnant or lactating women * contact lens wearers who do not discontinue lens use at least one week before baseline and follow-up exams

Keywords: mixed dry eye quantum molecular resonance (qmr) intense pulsed light (ipl) tear film stability dry eye treatment
comparison of different irrigation activation techniques on postoperative pain after endodontic treatment

Conditions: Postoperative Pain

Summary: the aim of this study is to evaluate the effect of different irrigation activation methods on postoperative pain using visual analog scale (vas) using xp-endo finisher, endoactivator and passive ultrasonic irrigation activation techniques with traditional irrigation method. in this study, traditional irrigation (gi), xp-endo finisher (xpf), passive ultrasonic irrigation (pui), endoactivator (ea) techniques will be used for irrigation activation. twenty-five maxillary or mandibular single root and canal-shaped nonvital teeth will used in each group. root canals will be prepared with tf-adaptive system. four different activation techniques will be applied during final irrigation. the canal treatments will be completed in one stage and postoperative pain analysis will be taken with vas (visual analog scale) scale after 12-24-48 hours. statistical analysis will be performed with mann whitney-u test.

vaious irrigation activation techniques have been used endodontic practice. these techniques are used to improve the activity of solutions. the selected techniques in this study are accepted as efficient methods for activation. however, postoperative pan is an important issue for clinicians. thus, traditional irrigation (gi), xp-endo finisher (xpf), passive ultrasonic irrigation (pui), endoactivator (ea) techniques will be used for irrigation activation. all techniques remove hard and soft tissue remnants successfully. the clinician expect to eliminate the postoperative pain. therefore, a possible increase in pain due to activation technique may limit the use of these methods. the pain scores will be measured using the scale and statistically analyzed.

Eligibility criteria:
inclusion criteria: * nonvital tooth * single rooted tooth exclusion criteria: * tooth not requiring root canal treatment * patients under 18 years old * vital tooth * tooth having more than 1 canal
efficacy and safety of phototherapy in the treatment of loss of smell post acute infection of coronavirus 19

Conditions: Smell Disorders

Summary: the aim of this study is to assess whether the use of a therapy combining olfactory training, corticoids, and phototherapy improves the proms compared to the use of olfactory training and corticosteroids only. to accomplish this goal the study will consist of 40 participants. the participants must present olfactory dysfunction for at least 4 weeks after a coronavirus-19 infection. furthermore, to be eligible each participant will need a polymerase chain reaction test with positive results for coronavirus-19.

standard operating procedures: patients attending consult and calls for follow-up. plan for missing data: missing data will be managed with statistical tests. statistical analysis: categorical variables, whenever dichotomous or nominal, will be reported as frequencies and percentages. normality will be assessed by the kolmogorov smirnov test. descriptive statistics will be reported as mean (standard deviation) or median (interquartile range). to analyze the correlation between quantitative variables, the parametric pearson test or the nonparametric spearman's test will be used, subjected to their distribution. differences between diffusing capacity for carbon monoxide groups will be analyzed for statistical significance by the chi-square test for categorical variables and by a two-sample t-test or wilcoxon rank-sum test for continuous variables as applicable. statistical significance will be set at a p-value less than 0.05. analyses will be performed using statistical package for the social sciences (v. 22.0) software.

Eligibility criteria:
inclusion criteria: * positive coronavirus polymerase chain reaction patients who experience loss of smell for more than 4 weeks after symptoms begin will be included in the study but at time of the trial with a negative result from a polymerase chain reaction. * patients older than18 years. exclusion criteria: * patients younger than 18 years. * pregnancy. * patients who do not have a positive real-time polymerase chain reaction for coronavirus * patients who have contraindications for corticosteroid therapy such as: 1. pregnant patients 2. immunosuppressed 3. patients with peptic ulcer 4. diabetics 5. patients with glaucoma

Keywords: anosmia hyposmia coronavirus smell disorders phototherapy
fractional ablative radiofrequency for the treatment of acne scars and wrinkles

Conditions: Wrinkles; Acne Scars

Summary: to assess the safety and efficacy of the pixel rf (fractional radio frequency) module in the treatment of acne scars and wrinkles.

the study design will be a prospective open label study. up to 20 subjects of both genders with acne scars and/or wrinkles in the face will be recruited. the subjects will be treated once on clean acne scarred skin and three times on the the wrinkled skin with the pixel rf handpiece. each treatment duration will be approximately 30 minutes. the initial power and number of passes parameters shall be set according to the clinical indication and skin type of the subject treated (as well as the results of test sites). clinical improvement will be assessed by the investigator physician from the visual appearance of the treated area according to the following scale: -1 for exacerbation, 0 no change, 1 for 1%-25% improvement, 2 for 25%-50% improvement, 3 for 50%-75% improvement, and 4 for 75%-99% improvement. adverse side effects will be scored by clinical evaluation of erythema, edema, and burns. real-time assessments will be made as well by the investigators. treatment and results will be documented in a case report form and follow-up sessions (1, 5 days after the treatment and 1 month and 3 months after the treatment).

Eligibility criteria:
inclusion criteria: * subjects meeting the following inclusion criteria may participate: * male or female subject 18-60 years of age. * clinically documented rolling and boxcar acne scars and/or wrinkles score of 2 or 3 per the rao-goldman scale (see section 6.5.1 for wrinkle classification). * limitation to acne scared and wrinkles area: face. * patients must commit to all follow-up visits. exclusion criteria: subjects meeting any of the following criteria will be excluded from participation: * bacterial or viral infection * impaired immune system * isotretinoin (accutane, amnesteem, claravis, and sotret) in the past 6 months * scleroderma * extensive radiation therapy * burns in the treatment area * poor healing in the treatment area * metal implants near the treatment area * implantable pacemaker or automatic defibrillator/cardioverter (aicd) * ablative/non-ablative cosmetic intervention (deep peeling) in the past 3 months in the areas to be treated * active cancer * active collagen or vascular disease * pregnancy or ivf procedure

Keywords: wrinkles acne scars
effect of high versus low-level laser therapy in patients of lumber radiculopathy

Conditions: Lumbar Radiculopathy

Summary: to compare the effects of high-level laser therapy (hllt) and low-level laser therapy (lllt) on pain in patients with lumbar radiculopathy.


Eligibility criteria:
inclusion criteria: * patients of both genders male and female will be included. * patients aged 40-65 years will be included. * patients with a diagnosis of lumbar radiculopathy confirmed by clinical evaluation by a physician or physiotherapist. * patients with a history of radicular leg pain and/or numbness or tingling sensation in the leg. * a positive score on the straight leg raise (pain between 35 degrees and 75 degrees), pain limiting functional ability, and scores at least 3/10 on the vas, restricted lumbar range of motion - 25% flexion, 20% extension. * patients who have not received any form of treatment for lumbar radiculopathy within the past 3 months exclusion criteria: * patients with a history of spinal surgery in the last 2 years or spinal deformity. * patients with a history of fracture or dislocation of the lumbar spine. * patients with a diagnosis of any other neurological disorder or neuropathy. * patients who are pregnant or breastfeeding. * patients with any other medical condition that may interfere i.e. inflammatory rheumatic disease, cardiac pacemaker, continuing that may interfere with the study outcomes or put them at risk with the study outcomes or put them at risk.

Keywords: hllt, laser therapy , lllt, lumber radiculopathy, sciatica
effects of low-dose naltrexone in combination with a range of smoked marijuana

Conditions: Marijuana Smoking

Summary: in heavy marijuana smokers, opioid receptor blockade increases the subjective and cardiovascular effects of marijuana. the current study was designed to clarify opioid-cannabinoid interactions by assessing how naltrexone shifts the dose-response function for marijuana-elicited effects in heavy marijuana smokers. for this within-subject, double-blind study, a marijuana smoking procedure was designed to characterize a dose-response relationship for marijuana's subjective and cardiovascular effects under blinded conditions.


Eligibility criteria:
inclusion criteria: * current marijuana use * able to perform study procedures * women practicing an effective form of birth control exclusion criteria: * current repeated illicit drug use (other than marijuana) * presence of significant medical illness (e.g., diabetes, cardiovascular disease,hypertension, hepatitis, clinically significant laboratory abnormalities, lfts \> 3x upper limit of normal, blood pressure \> 140/90

Keywords: naltrexone smoked marijuana marijuana use
interleukine 6 (il6) assay for predicting failure of spontaneous breathing in patients with covid-19 acute respiratory distress syndrome

Conditions: COVID-19 Acute Respiratory Distress Syndrome

Summary: in the current covid-19 pandemic, many patients have an acute respiratory distress syndrome (ards). among mechanisms related to covid-19 acute respiratory distress syndrome, cytokine storm and secretion of il-6 play a central role. ards management involves intubation for protective mechanical ventilation, deep sedation and curarisation. during intensive care unit (icu) hospitalization, improvement of hematosis induces a switch from a controlled ventilation mode to a withdrawal ventilation mode, such as spontaneous ventilation with pressure support (sp-ps) or adaptative support ventilation (asv). this step is essential prior to considering complete weaning from controlled ventilation and sometimes ends with a failure. in this case, deterioration of hematosis and/or ventilatory mechanics is observed. at the same time as withdrawal failure, the investigators observed biological inflammatory rebound in some patients. therefore, influence of inflammatory biological parameters, including il-6, on withdrawal failure, needs to be investigated. to this end, the investigators decide to dose different inflammatory markers - such as il6, c-reactive protein (crp), procalcitonin (pct) - in patients with acute respiratory distress syndrome due to covid-19, during standard of care. indeed, in patients with acute respiratory distress syndrome not due to covid-19, the increase in il6 is a negative prognosis during medical first aid but also when the mechanical ventilation is withdrawn. in addition, il6 rise is associated with poor prognosis for patients with covid-19 and longer stays in intensive care.


Eligibility criteria:
inclusion criteria: * age\>18 years * patients with covid-19 (positive covid pcr) * use of intubation for mechanical ventilation exclusion criteria: * use of extracorporeal membrane oxygenation * treatment with tocilizumab (anti-il6) * pregnant woman * patients under protective administration or deprived of liberty

Keywords: interleukin-6 acute respiratory distress syndrome covid-19
a study of the biodistribution and safety of [18f]gtp1 in healthy japanese participants

Conditions: Alzheimer Disease

Summary: the purpose of this study is to evaluate the biodistribution, safety and tolerability of a single dose of \[18f\]gtp1 as a tau targeted radiopharmaceutical in healthy japanese participants.


Eligibility criteria:
key inclusion criteria: * healthy with no clinically relevant finding on physical examination at screening and prior to radiopharmaceutical administration * female participants must be willing to avoid pregnancy and refrain from donating eggs during the treatment period and for 30 days after the final dose * male participants with partners of childbearing potential must commit to the use of two methods of contraception for the study duration and 90 days after the last dose * male participants must not donate sperm for the duration of the study and 90 days after the last dose * participants must have both japanese parents and all japanese grandparents key exclusion criteria: * participants with any significant medical disorder or disease expected to interfere with the study * current or prior history (within a six-month period) of exposure to nicotine products * history of drug or alcohol abuse within 12 months prior to screening * prior participation in other research protocols or clinical care in the last year, such that radiation exposure combined with that from the present study exceeds an effective dose of 50 millisievert (msv), the allowable annual limit for research participants as established by the us federal guidelines * use of any prescription drugs, herbal supplements, within 4 weeks prior to initial dosing * use of over the counter (otc) medication, dietary supplements, or vitamins, within 2 weeks prior to initial dosing * known hypersensitivity to any component of the formulation of \[18f\]gtp1 or related compounds * major surgery, or donation or loss of 400 ml or more of blood within 4 weeks prior to initial dosing * history of immunodeficiency diseases, including positive human immunodeficiency virus (hiv) test * positive for hepatitis b surface antigen (hbsag) or hepatitis c antibody * women who are pregnant, lactating or breastfeeding * unsuitable veins for repeated venipuncture
oral glucose tolerance testing (ogtt) on patients taking somatostatin analogs

Conditions: Acromegaly

Summary: the purpose of this study is to test the effect of long-acting somatostatin analog medications, taken by patients with acromegaly or carcinoid syndrome, on growth hormone in comparison to healthy controls who are not receiving the medication in order to see whether or not the medication makes the oral glucose test less accurate. the oral glucose tolerance test (ogtt) is a standard test to measure growth hormone secretion. by comparing gh responses in non-acromegaly subjects taking somatostatin analog treatment, the relative contribution of the medication and the underlying disease state can be analyzed.

subjects will be informed of the study and after providing written informed consent, subjects will be asked to undergo a 2-hour oral glucose tolerance test (ingestion of 75g glucose with subsequent timed assessment of growth hormone, glucose, insulin and related binding proteins.) baseline assessment of hormones that may contribute to the results will be drawn, prior to performing the test. patients will be asked to complete one visit total to participate in this trial.

Eligibility criteria:
inclusion criteria: * diagnosis of acromegaly or carcinoid syndrome * treatment with somatostatin analog therapy (must have established a stable dose of three or more injections on the same dose prior to study enrollment) * healthy control subjects exclusion criteria: * diagnosis of diabetes mellitus (type 1 or type 2) * use of medication for the treatment of insulin resistance or diabetes

Keywords: acromegaly growth hormone carcinoid syndrome somatostatin
characterization of placental diffusion

Conditions: Pregnancy in Diabetic; Placenta Diseases

Summary: dw-mri allows a quantitative comparison of diffusion as an expression of tissue hypoxia. the investigators aim is to compare changes in placental diffusion in pregnant women with uncontrolled diabetes compared to healthy pregnant women using dw-mri. the investigators hypothesize that placentas of diabetic mothers will show lower diffusion / perfusion compared to placentas of healthy women.

in highly uncontrolled diabetes there is an increased risk of intrauterine fetal death. the mechanism of fetal death is unknown and unpredictable. one of the theories points to hypoxia as a precursor to the death of the fetus in the womb. if the researchers succeed in predicting changes in the placenta with the help of mri, it may be possible to understand the mechanism of fetal damage as well as in the future to develop a protocol for predicting pregnancies prone to fetal death in the womb.

Eligibility criteria:
inclusion criteria: * women with pgam (pre-gestational diabetes) diagnosed before 20 weeks of pregnancy * women with gdma (gestational diabetes) diagnosed by ogtt after 20 weeks of pregnancy exclusion criteria: * pregnant women with placental hypoxia disease related in the past * pregnant women with placental hypoxia disease related in the present * non-singleton pregnancy * women in active labor or rupture of membrane * smoking women * suspicion of placenta accreta
the weight of cardiovascular disease

Conditions: Cardiovascular Diseases; Obesity

Summary: the purpose of this study is to evaluate the impact of a cardiometabolic clinic on percent body weight loss, body mass index (bmi), and visceral adiposity distribution in obese adults with cardiovascular disease (cvd) at 12 months.


Eligibility criteria:
inclusion criteria: * bmi ≥30 kg/m2 * at least one of the following cvd: atrial fibrillation (af), coronary artery disease (cad), hfpef (heart failure with preserved ejection fraction), hfref (heart failure with reduced ejection fraction), achd (adult congenital heart disease), or valvular heart disease * patients evaluated in the cardiometabolic clinic * willingness to complete questionnaires/surveys * ability to complete monthly self-assessments at home exclusion criteria: * bmi \<30 kg/m2 * pregnancy or lactating women * hemodynamically unstable cvd * active malignancy * autoimmune or systemic inflammatory diseases * severe renal or hepatic failure * being considered unsafe to participate as determined by the study physician * taking medications affecting weight or energy intake/energy expenditure in the last 6 months, including weight loss medications, antipsychotic medications, or other medications as determined by the study np or physician * patients with active psychosis, mania, or substance use disorders