Kornimate/medical-research-clean huggingface dataset:
gender differences in the tolerance to stretch

Conditions: Range of Motion, Articular; Muscle Stretching Exercises

Summary: the effect of stretching on range of motion is believed to rely upon an increased tolerance to stretch. this suggests, that pain modulation has significance in regards to the effect of stretching.

given that there may be differences in the way men and women perceive a painful stimulus, this suggests that there may be potential gender differences in the tolerance to stretch following stretching.

Eligibility criteria:
inclusion criteria: * absence of any pain or other conditions which might affect the somatosensory system and pain perception exclusion criteria: * substance abuse, history of neurological or mental disabilities, lack of ability to comply with instructions, delayed onset of muscle soreness
water-only versus water-co2 (hybrid) colonoscopy insertion technique

Conditions: Colon Polyp

Summary: the colonoscopy procedure involves insertion of a thin, flexible tube with a tiny camera inside (colonoscope) passed inside the bowel. to allow passage of the colonoscope and adequate visualisation of the lining of the bowel wall a range of techniques can be used. during colonoscopy, you can distend the colon with water, co2 and air. air is no longer recommended for gas insufflation during colonoscopy as it causes pain and excess bowel distention. so the options are water and/or co2 but it is not entirely clear which combination is the best and at what point during the colonoscopy. in practice, a hybrid technique where both co2 and water are used during the colonoscopy in used. here, water is exclusively used to help navigate the sigmoid colon with air pockets suctioned and turbid water exchanged with clean water. from splenic flexure to caecum a mixture of water and co2 is used. the aim of this study is to assess procedure comfort and efficiency of two different colonoscopy insertion techniques: water-alone insertion of the colonoscope (gas insufflation not allowed on insertion; water exchange technique) versus water-co2 hybrid insertion (water used predominately to splenic flexure with water/co2 used to caecum; modified water immersion technique).


Eligibility criteria:
inclusion criteria: * aged 18 years or older * capacity to consent exclusion criteria: * pregnancy * previous bowel surgery * unable to consent

Keywords: colonoscopy endoscopy
liverpool care pathway for the dying at residential care homes

Conditions: End-of-life Care

Summary: liverpool care pathway for the dying patient (lcp) was developed to transfer the care practice from the hospice setting to the hospital setting in uk. lcp is a pathway with standardized registration method to monitor the care and its results. the primary aim is to study the effects of lcp on dying patients symptom burden and communication with close relatives and health care professionals.

all residential care homes in skellefteå municipality are included in the study and randomized either to control or intervention group. during the baseline period the care is provided as usual. during the intervention period the lcp is used for patients for whom the dying phase is diagnosed in the intervention group. usual care is performed for the control group. after death of a patient a close relative fill in a questionnaire.

Eligibility criteria:
inclusion criteria: * nursing homes in skellefteå municipality, sweden exclusion criteria: -

Keywords: palliative care nursing homes liverpool care pathway
benefits of the involvement of nurses in meetings between physicians and the families of patients in the icu.

Conditions: Family Satisfaction; Healthcaregiver Satisfaction; Family PTSD; Family HADS; Family Traumatic Dissociation

Summary: when a patient is admitted to the icu this often happens so suddenly that this can create a significant amount of stress and anxiety for family members for several reasons. firstly, the family does not have a pre existing relationship with the icu team. secondly, the urgency of the situation and the technic it requires is often such that minimal information can be given to family members. and finally, as a result of the unpredictability of each patient's condition, it can be difficult to predict outcome for family members. together, these factors compound the stress and anxiety of family members. this anxiety is natural and it is important for health caregivers to be able to offer the best support possible. a high quality communication provided by structured information given by physicians and nurses as well could improve support to the families and lead to greater satisfaction. giving information to families during meetings is crucial at 3 moments: at the first day when the patient is admitted, at day 3, weekly and each time important news is given (surgery, deterioration in condition, end-of-life). the purpose of this project is to evaluate if the involvement of nurses during those meetings could improve quality in communication which is assessed by mixed methods. families and healthcare workers satisfaction will be assessed by qualitative methodology. family peritraumatic stress, symptoms of anxiety and depression and ptsd will be assessed using validated scales. training of healthcare workers will be done by role play. information to the families is delivered using a framework for physicians and nurses. all the meetings of the study will be audited by a psychologist.

-randomized trial with two arms: arm 1: information is delivered by a team (physician and nurse) arm 2: information is delivered by the physician alone -during the different meetings of the study: at day 1, at day 3, weekly and in case of deterioration of the patient condition. the other days, family information is delivered as usually in both arms.

Eligibility criteria:
inclusion criteria: 1. patient : adult, 1 relative at minimum, mechanically ventilated at least 48 hours; and 2. family : french-speaking, adult; exclusion criteria: * conflict, organ donor, refusal to participate.
acupuncture for persistent insomnia associated with major depressive disorder

Conditions: Insomnia; Depression

Summary: the purpose of this study is to evaluate the clinical effectiveness of acupuncture treatment on residual insomnia in major depressive patients.

this is a randomized single-blinded controlled trial. patients will be randomly assigned to one of the three groups. one is the traditional acupuncture treatment group, one is the non-traditional acupuncture treatment group and the other is an acupuncture-like placebo treatment. patients will be put into groups and then compared. the chance of getting into each group is 2:2:1.

Eligibility criteria:
inclusion criteria: * aged 18 years or above * a previous diagnostic and statistical manual of mental disorders-iv major depressive disorder * have a current diagnostic and statistical manual of mental disorders-iv diagnosis of insomnia disorder * insomnia more than 3 nights per week for at least 3 months * insomnia severity scale (isi) total score higher than 15 at screening and baseline visit * use of antidepressants at the same dosage for at least 12 weeks prior to screening visit * hypnotic dosage has not been increased in the last 4 weeks exclusion criteria: * have a hamilton depression rating scale scores above 18 * have sleep apnea or periodic limbs movement disorder detected by overnight polysomnography * have suicidal risk as assessed by the hamilton depression rating scale suicidal risk item * have previous history of schizophrenia, other psychotic disorders, and bipolar disorder * have current alcohol or drug abuse and dependence * pregnant, breast-feeding, or woman of childbearing potential not using adequate contraception * have infection or abscess close to the site of selected acupoints and in the investigator's opinion inclusion is unsafe * taking chinese herbal medicine or over-the-counter drugs which are intending for insomnia within the last 2 weeks prior to baseline or during the study * any acupuncture treatment during the previous 12 months prior to baseline and * unstable medical conditions.

Keywords: insomnia depression electroacupuncture acupuncture randomized clinical trial traditional chinese medicine
ct analysis comparing cast and three-point indexes in distal radius fracture care

Conditions: Distal Radius Fractures

Summary: objectives: to compare the cast index and three-point index measurements obtained using computed tomography (ct) with those acquired using conventional methods for treating distal radius fractures design: a retrospective cohort study setting: level 1 trauma center patients: one hundred and thirteen (45 men and 68 women) patients with distal radius fractures interventions: patients with distal radius fractures were retrospectively analyzed and received either conservative cast treatment or surgical intervention through open reduction and internal fixation between 2016 and 2022. main outcome measurements: the study evaluated the cast index and three-point index in the cast-treated group and their effectiveness using the sarmiento index. furthermore, radial height, volar tilt, and radial inclination were compared between the surgically treated and cast-treated groups.


Eligibility criteria:
inclusion criteria: * patients aged ≥18 years * diagnosed with distal radius fracture * treated with either cast or volar plate osteosynthesis were included in the study. exclusion criteria: * patients with multiple fractures in the same upper extremity * those treated with dorsal plates or external fixators * individuals with open fractures * patients with known systemic or rheumatologic diseases * those with cervical disk problems * individuals lacking post-cast removal ct data * patients with incomplete medical records were excluded.

Keywords: distal radius fracture cast index three point index computed tomography
simultaneous integrated boost radiotherapy and concurrent nimotuzumab or chemotherapy for esophageal carcinoma

Conditions: Esophageal Neoplasms

Summary: this prospective, non-randomized phase ii study aims to compare radiotherapy and concurrent nimotuzumab with concurrent chemoradiotherapy to obtain a non-inferior pcr rate and pathological lymph node metastases rate in premise of lower toxicities in locally advanced esophageal cancer.

in the era of imrt and concurrent chemoradiotherapy, the 5-year overall survival of esophageal cancer increase from 10% to about 20%-40%, recurrence rate decrease from 80% to 50%-60%, and local recurrence remains to be the most important type of failure. what called for is to enhance local control without increasing toxicity to improve survival. the investigators have found effective and safe regimen of simultaneously integrated boost radiotherapy in previous study, which can achieve high dose in tumor area with avoid of normal tissues. however, a recent prospective study reported that neoadjuvant chemoradiotherapy resulted in much higher toxicities compares to neoadjuvant chemotherapy (46% vs. 15%, p= 0.04). although chemoradiotherapy reached a higher pcr rate (28% vs. 9%, p=0.002), patients did not differ in survival in two groups. nimotuzumab is an humanized monoclonal antibody against egfr. radiotherapy combines nimotuzumab reveals synergistic effect in head and neck cancers with lower toxicities as compared to concurrent chemoradiotherapy. our previous study showed that egfr expression rate were similar in esophageal cancer and head and neck cancers. based on above results, the investigators design this study which aims to obtain a non-inferior pcr rate and pathological lymph node metastases rate in premise of lower toxicities.

Eligibility criteria:
inclusion criteria: * diagnosis of clinical stage t1-4an0-1m1a untreated squamous esophageal carcinoma * kps≥70 * adequate organ function * no known history of drug allergy exclusion criteria: * known drug allergy * insufficient hepatorenal function * severe cardiovascular diseases, diabetes with uncontrolled blood sugar, mental disorders, uncontrolled severe infection, active ulceration which need intervention.

Keywords: locally advanced esophageal cancer radiotherapy and nimotuzumab concurrent chemoradiotherapy
the absorption of magnesium oxide compared to citrate in healthy subjects

Conditions: Healthy Subjects; Hypomagnesemia

Summary: the magnesium food content in the western world is consistently reducing. hypomagnesemia is common in hospitalized patients, especially in the elderly with coronary artery disease (cad) and/or those with chronic heart failure. hypomagnesemia is associated with increased incidence of diabetes mellitus, metabolic syndrome, mortality rate from coronary artery disease (cad) and all cause. magnesium supplementation improves myocardial metabolism, inhibits calcium accumulation and myocardial cell death; it improves vascular tone, peripheral vascular resistance, afterload and cardiac output, reduces cardiac arrhythmias and improves lipid metabolism. magnesium also reduces vulnerability to oxygen-derived free radicals, improves human endothelial function and inhibits platelet function, including platelet aggregation and adhesion. the data regarding the absorption difference between supplemental magnesium oxide and magnesium citrate in humans is spare.

two oral preparations of magnesium are available in israel: 1. magnesium diasporal (magnesium citrate, elemental magnesium 98.6 mg), protina gmbh, ismaning, germany 2. magnox 520 tm (magnesium oxide, 520 mg elemental magnesium), naveh pharma ltd., israel. the data regarding the absorption difference between the two supplemental magnesium preparations (magnesium oxide and magnesium citrate) in humans is spare. primary objective: to find out the absorption of magnesium citrate compared to magnesium oxide in healthy subjects with no apparent heart disease.

Eligibility criteria:
inclusion criteria: 1. age 20-70 years 2. healthy subjects exclusion criteria: 1. chest pain 2. diabetes mellitus 3. documented coronary artery disease 4. asthma or any lung disease 5. chronic diarrhea 6. chronic renal failure (serum creatinine\> 3 mg/dl) 7. hypo or hyperthyroidism 8. heart failure 9. on any chronic therapy/medications 10. malabsorption 11. av block 12. pacemaker 13. any malignancy 14. obesity \> 30 kg/m2 body mass index 15. smokers 16. pregnancy 17. alcohol or drug abuse 18. any chronic inflammation 19. refuse to sign inform consent

Keywords: magnesium nutrition platelets aggregation
brain electrophysiological study(eeg/erp) on opiate addicts treating by bilateral nac/alic deep brain stimulation

Conditions: Substance-Related Disorders

Summary: drug addiction is compulsive and spontaneous drug-taking behavior which is characterized by non-medical usage, long and repeated exposure to addictive drugs and gradually increasing drug-taking dosage and frequency,and become a main threat against human being's public health, economic development and social safety.

effective treatments for severe drug addiction are limited. china centers employing compulsory detoxification, reported a 3 year abstinence rate of only 15%. for the methadone maintenance therapy, relapse often occurs promptly after cessation of methadone. a malaysian reports about taking naltrexone or buprenorphine treating,showed average relapsed time of 2 or 3 months,respectively. assessment for psychological craving degree of addiction patients is also a difficult thing.

Eligibility criteria:
inclusion criteria: 1. age between 18 and 65 years of age, male or female； 2. opiate addictive over 3 years； 3. physical detoxification completed（keep abstinent for at least 7 days，acute abstinent syndrome disappeared，morphine urinalysis and naloxone test showed negative)； 4. no obvious neuropsychiatry and personality disorders； 5. no severe infectious disease； 6. good compliance and be able to complete follow up； 7. general health is good，no severe liver、kidney、heart and lung disease； 8. informed consent issued exclusion criteria: 1. severe cognitive disorders（mmse scale: illiteracy≤17，primary school≤20，secondary school or above≤24）,bad compliance because of dementia,unable to issue the informed content； 2. history of severe neuropsychiatric disease； 3. epilepsy； 4. severe liver、kidney、heart and lung disease, severe hypertension and severe orthostatic hypotension； 5. malignant tumor；history of brain trauma；pregnant female； 6. patients are taking part in other clinical trials in recent 3 months； 7. being deem as unfit for the trials by researcher.

Keywords: drug addiction heroin craving event related potential crystal methamphetamine
prevalence of the wire syndrome

Conditions: Orthodontic Wires

Summary: the wire syndrome problem referred to dental displacements that can be described as aberrant, inaccurate, unexplained, or excessive on teeth still contained by an intact orthodontic wire, without detachment or fracture, leading to evolving dental and periodontal, aesthetic and/or functional consequences. the objective of this study was to define the prevalence of mandibular wire syndrome and the associated risk factors.


Eligibility criteria:
inclusion criteria:-students in their 4th, 5th, and 6th year of dental studies at the côte d'azur university - have undergone orthodontic treatment and are wearing a fixed mandibular retainer from canine to canine. exclusion criteria:'- orthodontic treatment in progress * absence/fracture of orthodontic fixed mandibular retainer * wearing a removable mandibular retainer.
umbilical cord mesenchymal stem cells in primary sclerosing cholangitis

Conditions: Primary Sclerosing Cholangitis

Summary: primary sclerosing cholangitis (psc) is an idiopathic condition with intrahepatic cholangitis and fibrosis, leading to multifocal bile duct stricture. its main clinical manifestations are chronic cholestatic lesions and is deemed as autoimmune liver disease. psc are immune abnormalities that occurs in patients with genetic susceptibility. no other pathogenesis is revealed yet. ursodeoxycholic acid is used as an empirical treatment, and there is no approved drug or a acceptable treatment regimen. the disease often progresses to liver decompensation and requires liver transplantation. in recent years, the clinical application of stem cell therapy has seen many important advances. stem cells are characterized with properties of multiple differentiation, repair of damaged tissue and immuno-modulation. this study aims to employ ucmscs to treat psc patients and observe its efficacy and safety, and to explore the possible therapeutic mechanisms.


Eligibility criteria:
inclusion criteria: * progressive psc * willing to give consent exclusion criteria: * decompensated liver cirrhosis * total serum bilirubin \>5uln * refractory ascites * serum creatinine \>1.5mg/dl * cirrhotic nodules with malignant tendencies * primary biliary cholangitis * igg4-associated sclerosing cholangitis * non-psc induced bile duct stones * biliary tract trauma * recurrent suppurative cholangitis * neoplastic disease * pancreatic disease
open label extension study with gefitinib (iressa™) for completing trial patients who may benefit from further treatment

Conditions: Non Small Cell Lung Cancer (NSCLC)

Summary: the purpose of this study is to provide gefitinib treatment to patients who, on completion or closure of other gefitinib clinical studies, were either receiving placebo treatment, or are continuing on the same dose and regimen of gefitinib established in their preceding study, for as long as the patients continue to derive benefit.


Eligibility criteria:
inclusion criteria: * patients who have completed preceding gefitinib therapy from either the 1839il/0709 (250mg dosing) study or 1839il/0710 (250mg dosing) study and in the opinion of the investigator may benefit from further gefitinib treatment. * no more than 14 days lapse in gefitinib treatment between the patient completing the preceding gefitinib clinical study and beginning of this study except when agreed by the astrazeneca physician. exclusion criteria: * any evidence of clinically active interstitial lung disease (patients with chronic,stable, radiographic changes who are asymptomatic need not be excluded). * in the opinion of the investigator, any evidence of severe or uncontrolled systemic disease (e.g. unstable or uncompensated respiratory, cardiac, hepatic or renal disease). * withdrawal, at any time, from the preceding gefitinib study. * concomitant use of phenytoin, carbamazepine, rifampicin, barbiturates, or st john's wort
a study comparing shared solutions® plus ms center support versus shared solutions® alone

Conditions: Multiple Sclerosis

Summary: to compare the effectiveness of a 90-day copaxone® adherence enhancement program for a sample of ms patients who are at high risk of nonadherence and receive support from shared solutions® and their ms center versus those who receive support only from shared solutions®.


Eligibility criteria:
inclusion criteria: 1. males or females, 18 years of age or older. 2. diagnosed with relapsing remitting multiple sclerosis (relapses accepted). 3. beginning or restarting therapy with glatiramer acetate (copaxone®). 4. willing and able to complete all procedures and evaluations related to the study. 5. willing to provide informed consent. exclusion criteria: 1. taking any other immunomodulatory or immunosuppressant therapy in conjunction with copaxone®. 2. has a significant medical illness other than ms that may interfere with the assessment of endpoints or the subject's participation in the trial for the full duration of the study. 3. any situation that the investigator or nurse (if not the investigator) feel may interfere with participation in the study. 4. pregnant or trying to become pregnant, or breast feeding during the study. 5. previously participated in this study or another clinical research study in the past 30 days.

Keywords: multiple sclerosis copaxone® shared solutions®