Kornimate/medical-research-clean huggingface dataset:
overnight weight loss and sleep structure

Conditions: Obesity; Healthy

Summary: the objectives of the present study are: 1. to evaluate if overnight weight loss is dependent on sleep structure assessed by polysomnography; 2. to compare weight loss rate during sleep and awake rest; 3. to compare night weight loss profile of normal and obese volunteers.

weight loss can be caused by loss of body mass due to metabolism and by water loss as insensible water loss, sweating, or excretion in feces and urine. eighty-three percent of the total weight loss is due to insensible water loss from airways and skin. water loss rate varies according to changes in activity and ambient temperature and humidity. although weight loss during sleep is a well-known phenomenon, there are no studies relating it to sleep structure or any other functions during the distinct sleep stages, particularly sws and rem sleep. there is evidence suggesting a homeostatic mechanism for weight control in animal models and humans. this mechanism is thought to be dependent on energy intake, energy expenditure, and environmental conditions. the literature suggests that sleep is important for weight homeostasis on a long term since sleep shortage is associated with overweight status, but overnight weight variation had not yet been studied. considering these facts, we hypothesized that the overnight weight loss rate is not uniform throughout the sleep period. we also intend to compare weight loss rate during sleep and awake rest. intervention: normal and obese volunteers will undergo whole night polysomnography with continuous body weight and temperature register after an adaptation night. after that, volunteers will remain awake resting in bed during the following day for continuous weight and temperature register.

Eligibility criteria:
inclusion criteria: * normal and obese volunteers exclusion criteria: * serious medical or neurological condition

Keywords: obesity weight loss rate sleep vigil metabolism actigraphy normal
the acceptability and feasibility of an ed-based, peer-delivered, suicide safety planning intervention

Conditions: Suicidal Ideation; Suicide, Attempted; Mental Health Issue

Summary: safety planning is a brief, ed-feasible intervention which has been demonstrated to save lives, and has been universally recommended by every recent expert consensus panel on suicide prevention strategies. in one popular version of the safety plan developed by stanley et al, the patient is encouraged to write out the following items: identifying personal signs of a crisis; helpful internal coping strategies; social contacts or settings which may distract from a crisis; using family members or friends for help when in crisis; mental health professionals who can be contacted when in crisis; and restricting access to lethal means. in most emergency departments, safety-planning is done by clinical personnel such as psychologists or social workers, but these providers are often too busy to perform safety-planning well or have multiple other patient care responsibilities. this study aims to find out if ed patients prefer to complete a safety plan with a peer supporter or clinical personnel. people who are visiting the emergency department for thoughts of self-harm will be asked to participate.

this project aims to answer the following three research questions: (1) in general, do ed patients with suicidal ideation/attempt prefer to interact with/receive support from peers with life experiences of suicide or clinical professionals who might have such life experiences or not? (2) will patients with suicidal ideation/attempt accept a peer-delivered safety planning intervention as opposed to one delivered by clinical personnel? (3) are peer-delivered safety plans of equal quality as those delivered by clinical personnel?

Eligibility criteria:
inclusion criteria: * patients presenting for suicidal ideation (si) or after a suicide attempt to the university of arkansas for medical sciences (uams) emergency department (ed) * willingness to engage in safety planning with trained non-clinical staff * english-speaking and english-writing (as translators will not be available for this study) exclusion criteria: * \ 89 years of age * patients appearing critically-ill * incarcerated or in police custody * currently intoxicated with alcohol or other substance * ed staff objection to patient enrollment in study * unwilling or unable to complete the safety plan with a peer supporter * unwilling or unable to show the safety plan to clinical staff

Keywords: suicide suicide prevention safety planning
efficacy of the unified protocol for the transdiagnostic treatment (up-a; ehrenreich-may et al., 2018) for adolescents with moderate emotional symptoms in educational settings

Conditions: Anxiety Disorder; Depressive Disorder; Emotional Problem; Emotional Disorder

Summary: the main goal is to assess the efficacy of the unified protocol for the transdiagnostic treatment (up-a; ehrenreich-may et al., 2018) for adolescents with moderate emotional symptoms in educational settings the goal is to prevent emotional symptoms and improve the socio-emotional adjustment.

emotional problems, such as anxiety and depression, are among the leading causes of associated disability and burden of disease worldwide among young people. therefore, it is necessary to address this emerging social challenge through the implementation of prevention strategies in relevant stages of development such as adolescence. in recent years, a transdiagnosis approach to emotional disorders has been promoted, highlighting the unified protocol for transdiagnostic treatment of emotional disorders and symptoms in its different versions (adulthood, adolescence, and childhood). in this context, the main goal is to assess the efficacy of the unified protocol for the transdiagnostic treatment (up-a; ehrenreich-may et al., 2018) for adolescents with moderate emotional symptoms in educational settings the goal is to prevent emotional symptoms and improve the socio-emotional adjustment. adolescents aged 12-18 at high risk of for anxiety and depression disorders (cut-off scores 10-15 points, phq-9 and gad-7) are selected. the design is a randomized controlled trial with two groups: active control (relaxation) and experimental (up-a). pre-test, post-test, and follow-up at 6, 12 and 18 months will be carried out. the impact of different behavioural, cognitive, affective, social, and academic functioning indicators is analyzed, as well as their effects in the short, medium, and long term. the satisfaction of the program by users (students, parents, and professionals) will also be evaluated. the implementation and validation of manualized and empirically validated psychological intervention programs, such as up-a, should be a priority in educational and socio-health policies.

Eligibility criteria:
inclusion criteria: * be 12-18 years old * written informed consent from adolescent and legal guardian * being able to understand and read spanish. * moderate depressive and anxiety symptoms according to the screening (score moderate level in the phq-9 and gad-7). exclusion criteria: * being diagnosed a mental disorder or alcohol and/or substance dependence disorder. * the presence of high suicidal risk * a medical disease or condition which prevent the participant from carry out the psychological treatment. * receiving another psychological treatment while the study is still ongoing. * the increase and/or changes in the medication of participants receiving pharmacological treatment during the study

Keywords: adolescents depression anxiety emotional problems transdiagnostic school evidence-based
tap water versus normal saline for wound irrigation

Conditions: Wound Infection Rate

Summary: this study is designed to compare the infection rates in wounds irrigated with sterile normal saline to those irrigated with chlorinated tap water. the hypothesis is that the wound infection rate subsequent to irrigation with tap water is not significantly different than the infection rate for wounds irrigated with sterile normal saline. inclusion criteria are patients older than 1-year of age who present to the emergency department with a soft-tissue laceration requiring repair. exclusion criteria include patients with any underlying immunocompromising illness, current use of antibiotics, puncture or bite wounds, underlying tendon or bone involvement, or wounds more than nine hours old. patients are randomized to have their wounds irrigated either with tap water or sterile normal saline prior to closure, controlling for the volume and irrigation method used. structured follow-up is completed at 48 hours and 30 days to determine the presence of infection. the primary outcome measure is the difference in wound infection rates between the two randomized groups.


Eligibility criteria:
inclusion criteria: • patients older than 1-year of age, who presented to the ed with an uncomplicated soft-tissue laceration requiring repair. exclusion criteria: * diabetes mellitus * asplenism * primary immune disorder * mechanical heart valve * chronic alcoholism * steroid use, * antibiotics use * immunosuppressive chemotherapy * wounds older than 9 hours or from a human or animal bite * puncture wounds * wounds associated with bone, tendon, or neurovascular injury

Keywords: wound irrigation tap water irrigation wound infection wound irrigation solution
efficacy evaluation of ucb-mncs in the treatment of refractory neonatal diseases

Conditions: Hypoxic-Ischemic Encephalopathy; Bronchopulmonary Dysplasia; Short Bowel Syndrome

Summary: hypoxic-ischemic encephalopathy (hie), bronchopulmonary dysplasia (bpd), short bowel syndrome (sbs) are refractory in clinical treatment. thus, how to better prevent such diseases is currently a key research topic in the international field. the use of cord blood-derived mononuclear cells may promote to save lives and improve patient outcomes.


Eligibility criteria:
inclusion criteria: * for children with hypoxic-ischemic encephalopathy (hie): meet the diagnostic criteria for hie. for children with bronchopulmonary dysplasia (bpd): 1) preterm infants with definite gestational age of 25-30 weeks; 2) birth weight 401-1249 g; 3) the risk of bpd was assessed to be greater than 60%. the scoring was based on the bpd high risk scoring system established by the nchd neonatal cooperative network; 4)parents read the subject's instructions, agreed to the treatment and signed the informed consent. for children with short bowel syndrome (sbs): 1) postoperative short bowel syndrome caused by neonatal necrotizing enterocolitis and other causes (developmental malformations of the digestive tract: intestinal atresia, anal atresia, intestinal stenosis, etc.); 2) parents read the subject's instructions, agreed to the treatment and signed the informed consent. exclusion criteria: * for children with hie: unable or unwilling to provide informed consent or unable to comply with trial requirements. for children with bpd: 1) with severe anemia, severe intracranial hemorrhage, pulmonary hemorrhage, congenital respiratory malformations (posterior nostril atresia, tracheoesophageal fistula, cleft palate, etc.), complicated congenital heart disease, diaphragmatic hernia, shock, other serious comorbidities or complications (congenital inherited metabolic diseases, endocrine diseases, severe congenital malformations and other diseases that affect lung development); 2) unable or unwilling to provide informed consent or unable to comply with trial requirements. for children with sbs: unable or unwilling to provide informed consent or unable to comply with trial requirements.
a study to investigate lung deposition of inhaled amikacin-loaded liposomes in healthy male participants

Conditions: Healthy Volunteers

Summary: the primary purpose of this study is to determine the intra and extra pulmonary deposition and clearance of inhaled amikacin-loaded liposomes by gamma scintigraphy in healthy male participants.


Eligibility criteria:
inclusion criteria: * participants with a body mass index (bmi) of 20-28. * participants with negative human immunodeficiency virus (hiv) and hepatitis b and c results. * participants with no clinically significant findings in 12-lead electrocardiogram (ecg) determined within 14 days of the start of the study. exclusion criteria: * participants who had clinically diagnosed asthma. * participants with a known allergic reaction to amikacin, liposomes or any of the radiolabelling products (i.e. \[\^99m\]tc, or \[\^111\]in, and \[\^81m\]kr). * evidence of clinically significant pulmonary, renal, hepatic, cardiovascular or metabolic dysfunction. * history of smoking within the past 12 months. * history of chronic cough or wheezing within the previous 21 days. * participants who had an upper respiratory illness or infection within the previous 21 days. * a history of drug or alcohol abuse. * donation of 450 milliliters (ml) or more blood within the previous 12 weeks. note: other inclusion/exclusion criteria may apply.
e-support for healthcare processes - asthma

Conditions: Asthma

Summary: the purpose of the study is to establish and clinically evaluate a new approach to treating asthma by using information and communication technologies (ict). a mobile environment, and organizational interventions to improve the process of an integrated treatment of people with asthma will be identified, developed, introduced and clinically evaluated.

a mobile environment to improve the process of an integrated treatment of people with asthma will be identified, developed, introduced and clinically evaluated. the study will include 120 patients diagnosed with asthma that is poorly managed. the study will use the act (asthma control test) questionnaire and an evaluation questionnaire that will cover issues regarding the satisfaction of subjects with asthma care offered. subjects with a pef meter, will be able to enter the value of pef (peak expiratory flow). in addition to this, users can enter values (1) physical activity (type, duration, intensity), and (2) food (type, quantity).

Eligibility criteria:
inclusion criteria: * act points \<19 * daily symptoms\> = 2 days/week * night symptoms\> = 1 night/week * rescue medication \> 2days/week * at least one asthma exacerbation in the past year, but not in the last month, which was treated with oral glucocorticoid exclusion criteria: * worsening of asthma in the last 4 weeks (treated with oral corticosteroids) * age \>70 or \<18 years * significant co-morbidity * does not own or know how to handle a mobile phone * no internet access * not able to perform a pef measurment * not able to use inhalor

Keywords: asthma ict support act pef
early colonoscopy for lower gastrointestinal (gi) bleeding

Conditions: Gastrointestinal Hemorrhage

Summary: study hypothesis is that performing early colonoscopy in patients who present to the hospital with lower gi bleeding improves their outcome. patients who are admitted with bleeding from their rectum and a negative endoscopic exam of the stomach and upper intestine are randomized (like flipping a coin) to receive a colonsoscopy either as an emergency (within 12 hours) or as a routine procedure (36 hours after admission). patients are followed during their hospitalization to see if they have further bleeding, if they require blood transfusions, if they need other diagnostic tests, if they need surgery or other treatments, and how long they stay in the hospital.

the aim of this study is to determine if performing early colonoscopy in patients who present to the hospital with lower gi bleeding improves their outcome. patients who are admitted with bleeding from their rectum and clinical evidence of a significant bleeding episode (elevated heart rate, low blood pressure, or need for blood transfusion) have immediate upper endoscopy (examination of the stomach with a flexible rubber tube with a light and video camera on the end). if this shows no source of bleeding, the patients are randomized (like flipping a coin) to receive a colonsoscopy (examination of the large intestine with a flexible rubber tube with a light and video camera on the end) either as a emergency (within 12 hours) or as a routine procedure (36 hours after admission). patients are followed during their hospitalization to see if they have further bleeding, if they require blood transfusions, if they need other diagnostic tests, if they need surgery or other treatments, and how long they stay in the hospital.

Eligibility criteria:
inclusion criteria: patients who are admitted with rectal bleeding and one of the following high-risk features: 1. hr \> 100/min 2. systolic blood pressure \<100 mmhg 3. orthostasis -considered as increase in hr by\> 20/min on assuming erect position as well as by decrease by 20 mmhg in systolic blood pressure 4. need for blood transfusion 5. drop in hemoglobin \> 1.5 g/dl or in hematocrit of \> 6% in 6 hours exclusion criteria: 1. inability to give informed consent 2. peritoneal signs 3. severe co-morbidities that would preclude the use of colonoscopy in standard clinical practice

Keywords: colonoscopy gastrointestinal bleeding
study to treat patients who have signs and symptoms of benign prostatic hyperplasia (bph) with tadalafil daily

Conditions: Benign Prostatic Hyperplasia

Summary: the purpose of this study is to determine whether an experimental drug known as tadalafil given once daily can reduce the symptoms associated with benign prostatic hyperplasia (straining, urinary frequency, feeling like your bladder is still full, etc.)


Eligibility criteria:
inclusion criteria: * men 45 years of age or older with benign prostatic hyperplasia (bph) also referred to as bph-luts \[lower urinary tract symptoms\] based on the disease diagnostic criteria at the start of study. * provide signed informed consent at the start of the study. * have not taken finasteride therapy for at least 3 months before study drug is dispensed and dutasteride therapy for at least 6 months before study drug is dispensed. * have not taken other bph therapy (including herbal preparations), overactive bladder (oab) therapy, or erectile dysfunction (ed) therapy for at least 4 weeks prior to study drug is dispensed. * agree not to use any other approved or experimental pharmacologic bph, oab, or ed treatments anytime during the study * have luts with a total international prostate symptom score (ipss) greater than or equal to 13 when study drug is dispensed. * have reduced peak urine flow rate when study drug is dispensed (measured by a special toilet equipment). * demonstrate compliance with study drug administration requirements. exclusion criteria: * treated with nitrates for a cardiac conditions. * have unstable angina or angina that requires treatment. * have had any of the following in the past 90 days: heart attack, also known as a myocardial infarction (mi); heart bypass surgery (called coronary artery bypass graft surgery); had a procedure to open up blood vessels in the heart known as angioplasty or stent placement (percutaneous coronary intervention). * have very high or very low blood pressure * have problems with kidneys, liver, or nervous system. * have uncontrolled diabetes. * have had a stroke or a significant injury to brain or spinal cord. * have prostate cancer, are being treated for cancer or have clinical evidence of prostate cancer (prostate-specific antigen \[psa\] greater than 10 nanograms/milliliter \[ng/ml\] at the start of study).

Keywords: signs and symptoms prostatic hyperplasia hyperplasia genital diseases, male prostatic diseases bph-luts
pre-operative rehabilitation exercise program for total knee arthroplasty

Conditions: Osteoarthritis; Rheumatoid Arthritis

Summary: the purpose of this study is to determine whether a pre-operative home rehabilitation exercise program designed for knee replacements is more effective than pre-operative usual care.

patients with lower levels of function prior to total knee arthroplasty (tka) attain lower functional endpoints after surgery. therapeutic exercise improves function in patients with arthritis of the knee, yet little evidence has examined the impact of pre-operative exercise for tka. single blinded randomized clinical trial comparing a pre-operative home exercise program to pre-operative usual care for patients who are waiting for tka.comparison group is usual care within the health region which does not include pre-operative rehabilitation program. primary outcome: womac function subscale. secondary outcomes: 1) quality of life; 2) ambulation; 3) self-efficacy; 4) anxiety; 5) patient satisfaction; 6) cost-effectiveness of this intervention. total enrollment: 230 patients if the intervention improves function prior to surgery, results will be clinically applicable for patients waiting for surgery

Eligibility criteria:
inclusion criteria: * primary unilateral total knee arthroplasty * poor functional status (womac=50 or greater) * 50 yrs or older * reside within health region * understands english exclusion criteria: * unicompartmental total knee arthroplasty * revision surgery
tofacitinib versus methotrexate as the first line dmard in the treatment of rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: it is a randomized controlled study

randomization controlled study on rheumatoid arthritis patients whos disease activity is high, controlled subjects will be given methotrexate and study subjects will get tofacitinib

Eligibility criteria:
inclusion criteria:1. age greater than 18 years 2. patients fulfill the acr-eular classification criteria for ra 3.das-28 crp more than 5.1 - exclusion criteria: 1. systemic infection 2. hemoglobin less than 9 mg/dl 3. wbc \<4000, neutrophil \<1000, platelet \<100000/mm 4. live vaccine within 3 months 5. gfr \< 50 ml/min 6. alt \> 2 times uln 7. pregnancy

Keywords: rheumatoid arthritis tofacitinib methotrexate
the role of genetic factors in the development of idiopathic osteoarthritis of the knee in the kazakh population

Conditions: Idiopathic Osteoarthritis

Summary: the purpose of this study is to identify genetic determinants of susceptibility to idiopathic osteoarthritis of the knee . it will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic osteoarthritis of the knee


Eligibility criteria:
inclusion criteria: 1. patients with bilateral idiopathic gonarthrosis aged 18 to 65 years; 2. representatives of the kazakh ethnic group up to the 3rd generation; 3. hereditary history of arthrosis; 4. persons who are able and willing to provide written informed consent; exclusion criteria: 1. patients with bilateral idiopathic gonarthrosis under 18 years of age and over 65 years of age; 2. representatives of other ethnic groups; 3. representatives of the kazakh ethnic group less than 3 generations; 4. no family history of bilateral idiopathic gonarthrosis; 5. patients with an acute period of the inflammatory process (laboratory and clinical signs); 6. persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; 7. pregnant or lactating women; 8. tuberculosis of any localization in the active phase and in history; 9. severe and decompensated diseases of the liver and kidneys, cardiovascular system; 10. severe and decompensated course of endocrine diseases; 11. autoimmune diseases; 12. systemic diseases; 13. oncological diseases;

Keywords: snp