Kornimate/medical-research-clean huggingface dataset:
sauna bathing to improve vascular health of adults with heart disease

Conditions: Coronary Artery Disease

Summary: this study is a clinical trial that will determine if sauna bathing improves blood vessel health in adults aged 50-70 years with heart disease.

mounting evidence suggests that heat therapy may improve cardiovascular health. recent analyses of a large cohort of middle-aged to older finnish men have established that frequent sauna bathing is associated with a reduced risk of cardiovascular mortality, of developing dementia and alzheimer's disease, and of developing hypertension. given the observational nature of these relationships, it remains unknown if the beneficial effects of sauna bathing can be directly attributed to heat exposure. the objective of this study is to test the primary hypothesis that 8 weeks of sauna bathing improves flow-mediated dilation, a measure of blood vessel health, in middle-aged to older adults (50-70 yrs) with stable coronary artery disease.

Eligibility criteria:
inclusion criteria: 1. a history of angiographic coronary disease: ≥70% arterial diameter narrowing of at least one major epicardial coronary artery and/or prior coronary revascularization and/or documented prior acute coronary syndrome and/or perfusion defect during exercise testing or pharmacological stimulation 2. stable medication doses (≥4 weeks) prior to enrolment 3. body mass index \<35 kg/m2 exclusion criteria: 1. recent (\<3 months) coronary artery disease-related hospitalization or change in angina pattern 2. unstable angina 3. ejection fraction \<40% and/or clinical evidence of heart failure 4. significant valvular heart disease 5. uncontrolled hypertension (\>180/110 mmhg)

Keywords: flow-mediated dilation sauna vascular heat
chemotherapy and biological therapy in treating patients with chronic phase chronic myelogenous leukemia

Conditions: Leukemia

Summary: rationale: drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. combining biological therapy with chemotherapy may kill more cancer cells. purpose: phase ii trial to study the effectiveness of chemotherapy with cytarabine and homoharringtonine and biological therapy with interferon alfa in treating patients with chronic phase chronic myelogenous leukemia.

objectives: i. determine the effectiveness of low dose cytarabine, homoharringtonine, and interferon alfa in stimulating a complete cytogenic response in patients with philadelphia chromosome positive early chronic phase chronic myelogenous leukemia. ii. evaluate the duration of the cytogenic response in these patients after this treatment. iii. determine differential success rates and analyze results by prognostic subsets (e.g., risk group, splenomegaly, thrombocytosis, age, etc.) in this patient population. outline: patients receive debulking therapy consisting of hydroxyurea until blood count is at proper level. patients then receive interferon alfa and cytarabine daily by subcutaneous injection. homoharringtonine is administered by continuous infusion on days 1-5. treatment continues for 5-7 years in the absence of unacceptable toxicity or disease progression (accelerated or blastic phase cml). if complete remission is achieved, peripheral blood stem cells are collected. patients are followed every 3 months for the first year and every 6 months thereafter. projected accrual: a total of 100 patients will be accrued for this study within 3 years.

Eligibility criteria:
disease characteristics: cytologically confirmed early chronic phase chronic myelogenous leukemia (cml) diagnosed within 12 months philadelphia chromosome positive or bcr positive no late chronic phase, accelerated phase, or blastic phase cml patient characteristics: age: 12 and over performance status: zubrod 0-2 life expectancy: not specified hematopoietic: not specified hepatic: bilirubin less than 2 mg/dl renal: creatinine less than 2 mg/dl cardiovascular: no severe heart disease other: no psychoses not pregnant or nursing fertile patients must use effective contraception prior concurrent therapy: biologic therapy: less than 1 month of prior interferon alfa chemotherapy: less than 1 month of prior cytarabine prior hydroxyurea allowed endocrine therapy: not specified radiotherapy: not specified surgery: not specified

Keywords: chronic phase chronic myelogenous leukemia philadelphia chromosome positive chronic myelogenous leukemia homoharringtonine hht cephalotaxus alkaloid cytarabine interferon alpha 2-a roferon-a ara-c depotcyt cytosine arabinosine hydrochloride
technology enhanced adolescent mental health (team)

Conditions: Nonsuicidal Self Injury; Alcohol Abuse; Vagus Nerve Stimulation

Summary: adolescent nonsuicidal self-injury (nssi) and alcohol misuse, alone and especially in combination, portend significant functional impairment in adulthood (e.g., relationship dysfunction, depression, suicidality). although psychosocial interventions for nssi and substance use are effective for some, they are also expensive and require highly trained clinicians. treatment is therefore often unavailable to disadvantaged adolescents and those who live rurally. thus, lower-cost alternative treatments are needed. we will evaluate the efficacy of noninvasive transcutaneous vagus nerve stimulation (tvns), an effective treatment for depression, in reducing risk for nssi and substance misuse among vulnerable adolescents.

the overarching goals of the proposed project are threefold. aim 1: evaluate the clinical efficacy of tvns in reducing nssi and alcohol misuse among vulnerable adolescents. we hypothesize that self-administered tvns, delivered in 25-minute sessions, will reduce self-reported nssi and alcohol use, improve adolescents' self-reported emotion regulation, and yield improvements in sympathetic and parasympathetic nervous system markers of emotion regulation and vulnerability to nssi and alcohol misuse. aim 2: evaluate treatment adherence compared with traditional psychosocial interventions of similar duration. we hypothesize that adolescents will demonstrate greater treatment adherence than observed in traditional psychosocial interventions of similar duration, and rate tvns as acceptable, unobtrusive, and favorable to face-to-face treatment. aim 3: evaluate maltreatment effects on tvns. we hypothesize that tvns will be effective for those with histories of maltreatment. although rarely used to date among adolescents, tvns alters neural and emotional responses to sad stimuli, and among adults, reduces suicide risk up to five years later. at present, it is being evaluated as a treatment for alcohol misuse in a nih-funded clinical trial. this suggests potential for treating nssi, alcohol misuse, post-traumatic stress symptoms (ptss), and other disorders of emotion dysregulation. as outlined above, we will test the efficacy of tvns in altering behavioral, emotional, and autonomic nervous system risk for nssi and alcohol misuse, evaluate adherence and acceptability of tvns among adolescents, and determine if maltreatment histories moderate treatment response.

Eligibility criteria:
inclusion criteria: * have used alcohol * have engaged in ≥ 3 episodes of nssi in the past 6 months or ≥ 5 lifetime (1 of these 5 must be in the past year) * own a smartphone (iphone or android) exclusion criteria: * autism * schizophrenia * have a cardiac pacemaker, implanted defibrillator, or implanted or metallic electronic device * pregnant or breastfeeding * have a history of seizures or epilepsy * temperomandibular joint disorder * bell's palsy * impaired cranial nerve function or facial pain

Keywords: adolescence emotion regulation
cyberknife radiosurgery and quality of life

Conditions: Bone Cancer; Central Nervous System Cancer

Summary: the purpose of this study is to look at pain control and qol improvement after treatment with ck radiosurgery for spinal metastases.


Eligibility criteria:
inclusion criteria: * patients with a spinal metastasis who will be treated with cyberknife radiosurgery. * there are no age or gender restrictions. * there are no life expectancy restrictions. * karnofsky performance status greater than 40. * negative pregnancy test or clinically assessed as not pregnant. * ability to understand and the willingness to sign a written informed consent document. exclusion criteria: * patients with benign tumors will not be included (neurofibromas, schwannomas, etc.) * other investigational medications or treatments will be noted, but will not preclude inclusion. * pregnant or nursing patients will be not be included in the study due to radiation exposure.
working memory training for children with dyslexia

Conditions: Dyslexia

Summary: the main aim of this interventional study is to investigate whether the effects of computerized working memory training improves reading abilities for children, i.e. ages 9 - 16 years, diagnosed with dyslexia.

dyslexia is a specific learning difficulty which mainly affects the development of literacy and language related skills. it is characterized by difficulties with phonological processing, rapid naming, working memory, processing speed and the automatic development of skills that may not match up to an individual's other cognitive abilities. phonological processing deficit is well established as one of the main causes of dyslexia. working memory (wm) is today considered to be a cognitive system that strongly relates to a person's ability to think and learn. over the last decade an increasing body of evidence indicates that wm deficits may cause particular problems for individuals with dyslexia. this is consistent with many of the every day problems reported by dyslexics and those around them. wm deficits are frequent in children with reading deficits. a major question is whether the wm impairment is secondary to phonological core deficit affecting the phonological loop only, or caused by an additional deficit involving central executive. exploratory findings from fmri studies indicates that impaired wm processes in dyslexia have a unique neuronal signature which may be associated with central executive processes. however there are conflicting findings and further studies are needed. the children in the study, all diagnosed with dyslexia, will be divided into two subgroups (16/16 children). they are randomly allocated to either the adaptive training group or the treatment as usual control group after the baseline assessment. both groups will meet for baseline testing and re-testing 4 weeks after completed training. those that serve as non-trained controls will be offered to participate in training after completion of the study. the intervention in this study aim to increase wm of children with dyslexia. we hypothesise that intensive computerized working memory training will improve reading fluency, speed and comprehension for children with dyslexia.

Eligibility criteria:
inclusion criteria: * dyslexia exclusion criteria: * mental retardation (iq below 70)

Keywords: working memory training, computerized dyslexia reading fluency reading comprehension
cardiac resynchronization therapy in pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: this study is being conducted to determine whether patients with advanced pulmonary hypertension when treated with cardiac resynchronization therapy improve hemodynamically and/or receive clinical benefit.

this study aims to determine whether stimulating earlier activation of the failing right ventricle in pulmonary hypertension reduces the effects of interventricular dependence in human subjects, thereby improving overall cardiac function and symptoms in patients with pulmonary hypertension and right ventricle failure with nyha class 3-4 symptoms.

Eligibility criteria:
inclusion criteria: * pulmonary hypertension, defined as pulmonary artery systolic pressure greater than 40 mm hg by transthoracic echocardiogram or right heart catheterization * lvef ≥ 50% * baseline 6mwt distant \<400 meters * baseline nyha functional class ≥ iii exclusion criteria: * lvef \< 50% * 6mwt duration \> 400 meters * nyha functional class \< iii * left bundle branch block * non-sinus rhythm * severe aortic stenosis (aortic valve area \< 1 cm2) * severe mitral regurgitation * acute cardiac failure * dependency on intravenous inotropies * severe obstructive pulmonary disease * hypertrophic obstructive cardiomyopathy * amyloidosis * dependence on pacing
chronic effect of mat pilates on neuromotor, cardiovascular functions and inflammatory markers in individuals post-stroke stroke and high blood pressure

Conditions: Stroke; High Blood Pressure

Summary: the pilates method aims to develop conscious control of body movements. in the literature there are studies that relate the method to postural stabilization, joint rehabilitation, treatment of low back pain, cancer and chronic obstructive pulmonary disease. however, studies on the modality\&#39;s potential for improving isokinetic and antihypertensive strength are scarce, particularly in post-stroke hemiparetic individuals with high blood pressure (bp). the objective of the study is to investigate changes in isokinetic strength and bp, in addition to functional capacity, balance, autonomic modulation, blood biomarkers and endothelial function in hemiparetic individuals due to stroke sequelae and/or with high bp (prehypertensive and hypertensive), after 12 weeks of training with mat pilates. eligible volunteers will be randomly divided into a mat pilates group with stroke (gp-ave), mat pilates group with high blood pressure (ha) (gp-ha), control group with stroke (gc-ave) and control group with ha (gc-ha ). on the first and second visit, measurements of isokinetic strength, functional capacity, static and dynamic balance, heart rate variability, cardiac output, stroke volume, endothelial function, total peripheral vascular resistance and blood biomarkers will be carried out. in addition, 24-hour bp will be measured by ambulatory monitoring (abpm). gp-ave and gp-ha will participate in a 12-week mat pilates program, totaling 36 training sessions lasting approximately 60 minutes, with an increasing degree of difficulty and complexity throughout the training period. gc-ave and gc-ha will be instructed to maintain their daily activities during the intervention period, then they will be invited to participate in the mat pilates program. the initial measurements will be repeated at the end of the intervention in the mat pilates and control groups. intra and intergroup comparisons will be carried out for all outcomes, for a significance level set at p ≤ 0.05.


Eligibility criteria:
inclusion criteria: hemiparetic individuals with a history of stroke and/or high blood pressure (prehypertensive and hypertensive patients) who are controlled and do not practice the pilates method. exclusion criteria: diagnosis of cardiovascular, respiratory, metabolic or locomotor disease that makes it impossible or contraindicates the practice of the proposed exercises; uncontrolled hypertension (systolic bp ≥160 mmhg or diastolic pressure and ≥105 mmhg at rest); spasticity: 3 according to the modified ashworth scale; smoking and frequencies in exercise sessions below 75%.

Keywords: autonomy hemodynamic balance muscle strength chronic reduction in blood pressure
an internet-delivered cognitive-behavioral intervention provided soon after trauma

Conditions: Post Traumatic Stress Disorder

Summary: the primary objective with this study is to investigate the feasibility of an internet-delivered cognitive-behavioral (cbt) intervention provided soon after trauma (within 2 months). the secondary objective is to investigate the effects of the internet-delivered cbt intervention on intrusive memories compared to no treatment.

objective the primary objective with this study is to investigate the feasibility of an internet-delivered psychological intervention provided soon after trauma (within 2 months). the secondary objective is to investigate the effects of the internet-delivered cbt intervention on intrusive memories compared to no treatment. trial design we will first pre-pilot test the intervention- and assessment procedures in five participants (no randomization) which will be followed by a randomized controlled trial with waitlist control. the wait list control group will also receive treatment after the first group has finished. sample size 5 plus 30 participants. endpoints self-report assessment of daily intrusions at baseline and post-treatment secondary endpoints the posttraumatic stress disorder checklist for dsm-5 (pcl-5) at baseline (and post-treatment montgomery åsberg depression rating scale - self-report (madrs-s) at baseline and post-treatment. euroqol, eq-5d at baseline and post-treatment. recruitment self-referral. advertising will be made through national newspapers, social media, patient organisations' and ads directed to health care units, such as emergency departments, in sweden. safety parameters participants will have the opportunity to report any adverse events during treatment at posttreatment and follow-up measurements. data collection: data will be collected electronically via the treatment platform and a safe app. main statistical analysis: between-group estimates on outcome are done using a mixed-effects regression model with a poisson distribution. all analyses will be done according to intention to treat and post hoc per protocol analyses will also be conducted. the primary criterion is the estimated regression slope of daily intrusive memories between day 0-7 and day 28-35.

Eligibility criteria:
inclusion criteria: * experienced psychological trauma according to criterium a for ptsd in the dsm-5 (exposed to death, threatened death, actual or threatened serious injury, or actual or threatened sexual violence) the past two months. * ongoing intrusive memories from this traumatic event * ≥ 18 years * situated in sweden * informed consent exclusion criteria: * other serious comorbidity as primary concern (ongoing substance dependence, untreated bipolar disorder, psychotic symptoms, severe depression, borderline personality disorder, high suicidal risk according to the mini) * not fluent speaking in swedish * receiving cbt for trauma * ongoing trauma-related threat (e.g. living with a violent spouse)
efficacy and safety of silfamin for common cold

Conditions: Common Cold; Sore-throat

Summary: this is a 2-arm, prospective, randomized, double-blind, placebo-controlled, and three-days-treatment clinical study comparing the efficacy and safety of silfamin at a dose of 2 tablets@150 mg twice daily in subjects with common cold.

there will be 2 groups of treatment; each group will consist of 30 subjects receiving the following regimens for three days: treatment i : 2 tablets of silfamin 150 mg 2 times daily treatment ii : 2 tablets of placebo 2 times daily eligible subjects will be evaluated for treatment efficacy at 0 hours (just before drug administration), 1 and 2 hours after the first dose. for the next doses, subject will perform a self-assessment for treatment efficacy at 1 and 2 hours after every dosing, and record it in subject's diary.

Eligibility criteria:
inclusion criteria: * otherwise healthy (by anamnesis) men or women aged 18 to 60 years with mild or moderate common cold with or without sore throat (common cold score of 1 or 2) * willing to participate in the study by signing the informed consent exclusion criteria: * body temperature of \> 37.3˚c and/or refuse to follow health protocol for covid-19 * known hypersensitivity to herbal drugs containing nigella sativa and/or phaleria macrocarpa * pregnant or lactating women * have received any analgesic, anti-inflammatory or other common cold preparation within the past 24 hours * presence of vomiting or diarrhea within the past 24 hours and still ongoing at the start of study * severe illness, e.g. severe hypertension (\> 160/100 mmhg)

Keywords: common cold sore-throat silfamin
multifocal visual performance study

Conditions: Presbyopia

Summary: the purpose of this trial was to compare the functional visual performance of precision profile multifocal (mf) contact lenses to progressive addition lens (pal) spectacles in a presbyopic population.

habitual contact lens wearers were randomized 1:1:1 to one of three commercially available multifocal contact lenses. progressive addition lens wearers wore their habitual spectacles. subjects were expected to attend 1 or 2 office visits. this study was terminated early by alcon due to slow enrollment and inconsistency in measurement of the primary endpoint.

Eligibility criteria:
inclusion criteria: * normal eyes, other than correction for refractive error; * habitual correction of either any multifocal contact lens with a maximum add of +2.00 diopter (d), or progressive addition lens spectacles with a maximum add of +2.00 d; * wears habitual correction at least 5 days per week and at least 6 hours per day. exclusion criteria: * monocular subjects; * subjects fit with only one contact lens; * known pregnancy or lactating; * history of or planned refractive surgery or irregular cornea in either eye. other protocol-specified inclusion and/or exclusion criteria may apply.

Keywords: contact lenses multifocal spectacles glasses progressive vision eyes
improvement the anti-migraine treatment efficacy by tailoring the drug to individual's pain modulation profile

Conditions: Pain

Summary: * to delineate brain mechanisms that subserve endogenous analgesic (ea) in the healthy state. * to identify alterations in mechanisms supporting ea in chronic pain (migraine) and their therapeutic relevance.

the proposed research will use psychophysics and multiparametric mri to (i) delineate the brain mechanisms that subserve and regulate endogenous analgesia (ea)in the healthy state and (ii) to identify alterations in mechanisms supporting ea in chronic pain and their therapeutic relevance. in both healthy subjects and chronic pain patients, ea will be probed using the dnic (diffuse noxious inhibitory controls) and offset analgesia paradigms. functional mri will examine activation of brainstem mechanisms important in ea, while both functional and structural connectivity analyses will assess the regulation of these brainstem mechanisms by cerebral cortical regions involved in attention and affect. one pathological painful condition, migraine, will be examined since it allows changes in ea associated with chronic pain to be investigated between episodes of pain. finally, ea and ea associated structural and functional parameters will be used to predict the efficacy of one compound, amitriptyline, to treat migraine in individual patients. taken together, the proposed research will provide substantial insights into basic mechanisms supporting and regulating ea and can provide a foundation for mechanism-based individualized choice of therapy that may benefit all chronic pain patients.

Eligibility criteria:
inclusion criteria: * healthy females * migaine females * ages 18-50 * for migraineurs: \>4 attacks/month exclusion criteria: * any migraine preventive treatment received during last 3 months or prior treatment with amytriptiline * other chronic pain conditions * psychiatric, other neurological diseases, language barrier or cognitive dysfunction * patients and controls will be asked to withdraw from any pain-relieving medications for 24 hours before the testing. the tests will be performed interictally atleast 2 days after the last attack.

Keywords: endogenous pain modulation migraine fmri duloxetine preventive migraine treatment