Kornimate/medical-research-clean huggingface dataset:
pilot study comparing two techniques of taking care analgesic in patients 70 and older, awaiting surgery after extracapsular fracture of the proximal femur

Conditions: Femoral Fractures

Summary: the fracture of the proximal femur is a common traumatic pathology in patients aged over 70 years, associated with a mortality of 20 to 30% a year. the care is delayed emergency. during this wait, the occurrence of heel pressure ulcers is regularly found, despite wearing antiescarres slippers. mobilization, source of pain, is also problematic. 759/5000


Eligibility criteria:
inclusion criteria: * patient aged 70 and over, * extracapsular fracture isolated from the proximal end of the femur, * informed consent of the patient for participation in the study, * patient affiliated to a social security scheme. exclusion criteria: * restlessness or fragile skin condition that may prevent the establishment or maintenance of traction stuck preoperatively * insane or confounding pathology, * predictable time before operation\> to 72 hours (eg anticoagulated patient orally before the fracture \[antiplatelet agents are allowed\], other associated diseases: urinary tract infection, pneumonia ...) * patient under guardianship, curatorship, or under judicial protection.
bariatric surgery and obstructive sleep apnea

Conditions: Obstructive Sleep Apnea; Bariatric Surgery

Summary: more often than not, obesity occurs in tandem with obstructive sleep apnea (osa), and each disease effectively perpetuates severity of the other. surgical weight loss (i.e. bariatric surgery), and nocturnal, positive airway pressure therapy (pap) are used to treat the two conditions separately, and these treatment modalities both present a unique set of challenges in terms of patient-adherence. furthermore, the combined effects of these therapies on body weight and osa severity are unclear, and require longitudinal investigation. the purpose of the research proposed herein is twofold: a) to prospectively demonstrate the specific physiologic/psychological improvements in osa risk factors and disease severity that occur in a subset of bariatric surgery patients with osa, who are being effectively treated with pap and furthermore; b) to elucidate differences in postoperative outcomes (weight-loss, dyslipidemia, osa severity, comorbidity resolution) between patients who are compliant or non-compliant with prescribed pap therapy. the investigators anticipate that results will be used to develop and streamline approaches to improve pulmonary/sleep-related outcomes in bariatric surgery patients. furthermore, this line of research has many implications for strategies to strengthen the coordination of care between bariatric surgery, pulmonology, and other clinical sub-specialties that are integral to the postoperative health of these patients.


Eligibility criteria:
inclusion criteria: * obese (body mass index \> 35) * pending laparoscopic roux-en-y gastric bypass at summa bariatric care center * women * ages 20 - 85 * diagnosed osa and prescribed nocturnal, autotitrating positive airway pressure therapy exclusion criteria: * are excluded if failure to meet any of the above
a study to evaluate the effect of hepatic impairment on the pharmacokinetics of erdafitinib

Conditions: Hepatic Impairment

Summary: the primary purpose of the study is to characterize the single dose pharmacokinetic of erdafitinib in participants with impaired hepatic function relative to participants with normal hepatic function.


Eligibility criteria:
inclusion criteria: * man or woman must have a clinically stable hepatic function as confirmed by the serum bilirubin and transaminase levels measured during screening and those measured on day -1 * if a woman (a) must not be of childbearing potential postmenopausal or surgically sterile (b) must agree to not donate eggs (ova, oocytes) for the purposes of assisted reproduction during the study and for 3 months after the study drug administration * if a woman who is considered surgically sterile but not postmenopausal, must have a negative serum beta-human chorionic gonadotropin (beta-hcg) pregnancy test at screening (exemptions: pregnancy test not required in female participants with prior hysterectomy or prior bilateral oophorectomy) * if a woman, must agree not to donate eggs (ova, oocytes) for the purposes of assisted reproduction during the study and for 3 months after the study drug administration * participants with hepatic impairment must meet the child-pug classification for mild, moderate or severe hepatic impairment and must have stable hepatic function exclusion criteria: * history or current evidence of ophthalmic disorder, such as central serous retinopathy (csr) or retinal vein occlusion, active wet age related macular degeneration, diabetic retinopathy with macular edema, uncontrolled glaucoma, corneal pathology such as keratitis, keratoconjunctivitis, keratopathy, corneal abrasion, inflammation or ulceration * any surgical or medical condition that may alter the absorption, metabolism, or excretion of the study drug (example, gastrectomy, crohn's disease etc), with the exception of hepatic impairment * history of drug abuse according to diagnostic and statistical manual of mental disorders (5th edition) (dsm-v) criteria within 6 months before screening or positive test result(s) for drugs of abuse (including barbiturates, opiates, cocaine, cannabinoids, amphetamines, hallucinogens, and benzodiazepines) at screening and on day -1 * known allergy to the study drug or any of the excipients of the formulation (physical description of study drug\[s\], for a list of excipients) * donated blood or blood products or had substantial loss of blood (more than 500 milliliter \[ml\]) within 3 months before study drug administration or intention to donate blood or blood products during the study
uv dosimetry feedback in nmsc patients

Conditions: Non-Melanoma Skin Cancer

Summary: this study aims to characterize uv exposures among nmsc patients (those with a history of skin cancer) and to pilot an innovative behavioral intervention to decrease modifiable uv exposures. it will use uv dosimeters to objectively measure uv exposure and provide time and activity specific uv data on an individual level. these data will be used to develop a targeted and personalized behavioral feedback plan with counseling aimed at effective sun exposure behavior change

the study will focus on helping to prevent nmsc and its associated morbidity through learning when patients are unintentionally exposed to extreme uv radiation. it will then help to create manageable and realistic behavioral interventions to reduce exposure, while also educating patients of the dangers of abundant sun exposure.

Eligibility criteria:
inclusion criteria: * patients between ages 18 and 50. * must be diagnosed with non-melanoma skin cancer. exclusion criteria: * patients, who at the discretion of the clinician, are too ill or sick. * non-english speaking patients.

Keywords: uv dosimetry uv exposure behavioral social cognitive theory self-regulation self-efficacy
systemic inflammation in chronic obstructive pulmonary disease (copd)

Conditions: Chronic Obstructive Pulmonary Disease

Summary: copd is ranked number 3 by the who list of important diseases worldwide and is the only disease with increasing mortality. the pathogenesis of cigarette smoke-induced copd is obscure, therefore more insight is needed to design effective anti-inflammatory agents. recently it has become clear that cigarette smoke-induced inflammation is not only present in the lungs but also in the blood, and that this systemic inflammation has important consequences for the clinical expression of copd. the investigators hypothesize that healthy individuals who are susceptible to cigarette smoking demonstrate a higher and aberrant systemic inflammatory response to cigarette smoke. this susceptibility is caused by heterogeneous factors and is associated with various polymorphic genes that interact with each other and with the environment. objective: * to study systemic inflammation in individuals who are or are not susceptible to develop copd. * to characterize the switch to chronicity of the systemic inflmmatory response in copd * to determine whether the type and severity of the systemic inflammation contributes to the clinical outcome of copd * to compare between subjects who are or are not susceptible to develop copd in peripheral blood, the corticosteroid responsiveness in vitro, and to unravel underlying mechanisms. * to study the role of candidate genes that may play a role in the development of fixed airway obstruction, and to identify clues for patient's responsiveness to specific drugs * to develop new biological and clinical markers for the early diagnosis and monitoring of copd * to define possible mediators involved in the early induction of copd in susceptible smokers, and to define new drug targets


Eligibility criteria:
inclusion criteria: age ≥18 and ≤75 years * age, pack years, fev1/fvc and fev1% predicted must fit in one of the 9 groups of the study population * physically and mentally able to undergo the total study protocol * written informed consent exclusion criteria: * participation in another study * alpha-1-antitrypsin deficiency * selected grade 1-3 co-morbidity listed in the ace-27 * active pulmonary infection like tuberculosis, pneumonia, flue, tracheobronchitis * active extra-pulmonary infection like hepatitis a-c, cystitis, gastro-enteritis etc * pulmonary diseases like sarcoidosis, pulmonary fibrosis, silicosis, hypersensitivity pneumonitis, asthma * life threatening diseases like carcinoma, aids (including hiv+), acute leukaemia etc * medication that may affect the results of the study: nsaid's, immunosuppressive agents like prednisolon, metotrexate, azathioprine

Keywords: copd inflammation smoking susceptibility
micturition reeducation in children with cerebral palsy

Conditions: Daytime Urinary Incontinence

Summary: this study evaluates the effectiveness of a voiding reeducation program as treatment for incontinence in children with a brain injury.

children with cerebral palsy (cp) (rosenbaum, 2007) gain bladder and bowel control at older age compared to typical developing children (ozturk, 2006). the incidence of urinary incontinence during day and night, fecal incontinence and constipation is higher in this population. incontinence in children is often treated with urotherapy. this is a nonsurgical, nonpharmacological treatment for lower urinary tract dysfunctions. standard urotherapy is noninterventional and it includes giving information, instructions, advice regarding life-style, fluid intake and bladder diaries. additionally specific interventions can be used, such as: various forms of pelvic floor training, behavioral modification, biofeedback, electrical stimulation and catheterization (neveus, 2006). recent research has proven urotherapy to be successful for the treatment of children with daytime incontinence (mulders, 2010). despite the high prevalence of incontinence in children with cp the possible treatment strategies in this population are poorly investigated. far too often, urinary incontinence in children with cp is considered a normal, unavoidable and even a minor problem. aim: investigate the influence of individualized urotherapy on the (in)continence of children with cp. the included children with cp will be randomized and stratified for type of cp and mental abilities into 2 groups: the intervention group and the control group. the intervention group will receive immediate therapy. after one year of therapy, a follow- up of 6 months will be applied. the control group will start 6 months later and information will be used as control group. incontinent children without cp will receive therapy and will also act as control group.

Eligibility criteria:
inclusion criteria: * daytime urinary incontinence with or without enuresis and/or fecal incontinence * cerebral palsy (arms of children with cp) * normal development (arms of children without cp) exclusion criteria: * isolated urinary tract infections * isolated enuresis * isolated dysfunctional voiding * isolated fecal incontinence * anatomical abnormalities * history of genitourinary or renal surgery * medication for incontinence during the last 3 months * pelvic reeducation during the last 6 months * other neurologic problems influencing continence

Keywords: urinary incontinence cerebral palsy urotherapy child
effect of fire suppression and emergency duties on vascular function

Conditions: Vascular Function; Atherothrombosis

Summary: firefighters are at increased risk of death from heart attacks when compared to other emergencyy service professionals whose jobs involve similar components such as emergency call-outs and shift work. in the largest analysis of cause of death amongst on-duty firefighters, firefighter deaths were classified according to the duty performed during the onset of symptoms or immediately prior to any sudden death. the majority of deaths due to a cardiovascular cause (i.e. heart attack) occurred during fire suppression whilst this activity represented a relatively small amount of a firefighters professional time. there was also a risk of death associated with other duties such as emergency non-fire response and physical exertion. the investigators hypothesize that participation in active fire-fighting duties impairs blood vessel function and increases blood clot formation when compared with non-fire-fighting activities. in this study, healthy career firefighters will be assessed after three periods of duty: fire-suppression, emergency response without fire suppression and following a sedentary shift. the investigators will take blood samples to measure platelet activity (platelets are the particles in blood that help blood clot) and will examine how blood clots outside of the body. the investigators will then perform studies placing small needles in the arm to assess blood vessel function following these duties. by undertaking this comprehensive assessment of blood, blood vessel and heart function the investigators hope to understand the mechanisms whereby the risk of a heart attack, fatal or otherwise, is posed throughout these distinct duties that firefighters undertake on a daily basis.


Eligibility criteria:
inclusion criteria: * non-smoking healthy firefighters exclusion criteria: * current smoker * history of lung or ischaemic heart disease * malignant arrhythmia * systolic blood pressure \>190mmhg or \<100mmhg * renal or hepatic dysfunction * previous history of blood dyscrasia * unable to tolerate the supine position * blood donation within the last 3 months * recent respiratory tract infection within the past 4 weeks * routine medication including aspirin and nsaids

Keywords: firefighters myocardial infarction endothelial function thrombosis fire suppression non-fire emergency duty sedentary shift
nettunit - italy-tunisia cross-border environmental network_1

Conditions: Respiratory Disease; Cardiovascular Diseases

Summary: retrospective, case-crossover study aiming to use environmental pollutant data for assessing the associated risk of visiting the emergency room (er) for respiratory or cardiovascular problems in the territory of the caltanissetta provincial health authority (italy). all the er visits for respiratory and/or cardiovascular disorders in the hospital of gela (italy) and niscemi (italy) from 2010 to 2019 will be considered.


Eligibility criteria:
inclusion criteria: * all emergency room visits for respiratory or cardiovascular problems at the hospital of gela (italy) and niscemi (italy), from 2010 to 2019. exclusion criteria: * emergency room visits for other diseases.
functional connectivity parkinson disease

Conditions: Parkinson Disease

Summary: in this study the investigators are looking at two subtypes of parkinson disease (pd); "tremor-dominant" (td) and postural imbalance and gait disorder (pigd). this study will use magnet resonance imaging (mri) to see how the brain reacts while resting and doing a finger-tapping task while on and off pd medication. this study will look at the differences between the two sub-types of pd and healthy volunteers. the investigators will test the hypothesis that connectivity at rest within the motor cortex and between the motor cortex and motor-associated regions such as the supplementary motor area and the pre motor cortex will not be as strong in pigd compared to td (increased activity and functional connectivity in td group)


Eligibility criteria:
inclusion criteria: * english as their primary language * patients with parkinson disease and healthy controls will be enrolled * parkinson patients must be on a dopaminergic medication (levodopa or dopamine agonist) and on a stable dose over the prior month exclusion criteria: * if unable to provide informed consent * pregnancy * excess of 300lbs * claustrophobia * metal in body * untreated neurological or psychiatric condition, who are delusional or have hallucinations, with cognitive impairment (moca\<26), with a history of head injury sufficient to cause a concussion, or with significant systemic medical diseases (e.g. heart failure, liver failure, kidney failure, poorly controlled diabetes, etc.) * healthy control subjects will be excluded if taking any type of dopaminergic or anti-dopaminergic medication * subjects who are unable to demonstrate understanding of the study procedures and risks will be excluded

Keywords: parkinson parkinson disease
in vitro maturation with in vitro fertilization (ivf) compared to mild in vitro fertilization

Conditions: Infertility

Summary: methods of infertility treatment may involve in vitro fertilization or ivf. though effective, ivf is complex and expensive. methods using no gonadotropin hormone stimulation of the ovaries are being compared to mild stimulation doses. the goal of the research is to determine which of these if more suitable as a low cost approach for varying individual patients.

low cost environment is utilized, but fees are charged.

Eligibility criteria:
inclusion criteria: * under age 42 female, normal uterine cavity, bmi 18-34kg/m2, exclusion criteria: * donor eggs, donor sperm, myoma over 5 cm * current hydrosalpinx, abnormal uterine cavity.

Keywords: polycystic ovaries, tubal occlusion unexplained infertility low ovarian reserve male factor infertility
close-guided pulmonary vein isolation using high power and stable rf applications

Conditions: Atrial Fibrillation

Summary: in this prospective, randomised, controlled, unblinded,monocentric study, we aim to evaluate the safety and efficacy of higher power close-guided pvi in patients referred for a first ablation for paroxysmal af. we aim to include 100 patients into two groups (1:1). the experimental group will receive af ablation with 45 watt and stricter stability criteria (3 mm for 3 seconds) compared to the control group which will receive af ablation according to the standard close-protocol (35 watt and stability criteria of 3 mm for 8 seconds).

background: in a population of paroxysmal af 'close'-guided pvi (target ablation index (ai) \>550 and \>400 for anterior and posterior wall respectively, interlesion distance ≤6mm) has been shown to obtain single-procedure durable pv isolation. however, the optimal rf power and stability criteria is unknown. objectives: with this study, we aim at evaluation the efficacy and the safety of higher power (45 watts) and stricter stability criteria (3 mm for 3 sec) as compared to a standard close protocol (35 watts with stability of 3 mm for 8 sec) in patients referred for a first ablation for paroxysmal af. population: eligible patients are patients with paroxysmal af who are planned for a 'close'-guided pv isolation for paroxysmal af. at the time of the procedrual planning, we will ask the patient his/her consent for collectio of data. we aim at including 100 patients.

Eligibility criteria:
inclusion criteria: * all patients referred for symptomatic paroxysmal af and without advanced structural heart disease * signed patient informed consent form * age 18 years or older * able and willing to comply with all follow-up testing and requirements exclusion criteria: * persistent atrial fibrillation (history of af\>7days or history of cardioversion \> 48h of af) * previous ablation for af * la antero-posterior diameter\>50 mm (parasternal long axis view , plax) * lvef \<35% (ejection fraction) * af secondary to electrolyte imbalance, thyroid disease, or reversible or non-cardiac cause * cabg procedure within the last three months * awaiting cardiac transplantation or other cardiac surgery * documented left atrial thrombus on imaging * diagnosed atrial myxoma * women who are pregnant or breastfeeding * acute illness or active systemic infection or sepsis * unstable angina * uncontrolled heart failure * myocardial infarction within the previous two months * history of blood clotting or bleeding abnormalities * contraindication to anticoagulation therapy (ie, heparin or warfarin) * life expectancy less than 12 months * enrollment in any other study evaluating another device or drug * presence of intramural thrombus, tumor or other abnormality that precludes catheter introduction
a study to evaluate the efficacy and safety of lci699 compared to placebo in participants with resistant hypertension

Conditions: Hypertension

Summary: this study assessed the blood pressure effect, safety and tolerability of lci699 compared to placebo and eplerenone in participants with resistant hypertension.


Eligibility criteria:
inclusion criteria: * diagnosis of hypertension with mean sitting systolic blood pressure (mssbp) ≥140 millimeters of mercury (mmhg) and \<180 mmhg * stable on a three-drug regimen (including a diuretic) for at least 4 weeks for the treatment of resistant hypertension * male and female participants 18 to 75 years of age exclusion criteria: * recent history of myocardial infarction (mi), heart failure, unstable angina, coronary artery bypass graft, percutaneous coronary intervention, hypertensive encephalopathy, cerebrovascular accident, or transient ischemic attack * clinically significant electrocardiography (ecg) findings related to cardiac conduction defects * type 1 diabetes or uncontrolled type 2 diabetes (haemoglobin a1c \[hba1c\] \>9%) * malignancies within the last 5 years (excluding basal cell skin cancer) other protocol-defined inclusion/exclusion criteria may apply.

Keywords: blood pressure hypertension resistant hypertension
comparison of active release technique and bent leg raise in osteoarthritis.

Conditions: Knee Osteoarthritis

Summary: the objective of the study was to compare the effects of active release technique and bent leg raise on hamstring flexibility, functional outcomes, and pain in patients with knee osteoarthritis.

knee osteoarthritis is a common progressive degenerative joint disease. muscular weakness and other structural abnormalities can cause low back pain. hamstring muscle being a postural muscle has an increased tendency to become tight. in this study, participants with knee osteoarthritis having hamstring tightness were included. active release technique and bent leg raise technique have been used to increase flexibility in hamstrings in these patients with knee osteoarthritis.

Eligibility criteria:
inclusion criteria: * diagnosed patients of knee osteoarthritis * hamstring length less than 160 degrees * minimum history of 3 months * willing to participate exclusion criteria: * patients who have passive knee extension more than 160 degrees * patients with less than 3 months history * patients who have osteoarthritis of other than the knee joint * patients with history of fracture * patients with post surgical history

Keywords: active release technique bent leg raise hamstring flexibility