Kornimate/medical-research-clean huggingface dataset:
wholebody mri in lung cancer staging

Conditions: Lung Cancer

Summary: magnetic resonnace imaging (mri) and positron emission tomography (pet) can be both used in detection of nodes in patients with cell lung cancer (nsclc). however, the cardiorespiratory synchronization in the mri, allowing acquisition of synchronous images with breathing and heart movements should increase the sensitivity of detection of pathologic mediastinal lymph nodes. given its high sensitivity, whole-body mri with diffusion could possibly be at least as informative as pet, while being less expensive, not radiant. the purpose of this study is to evaluate the performance of whole-body mri with diffusion with cardiorespiratory synchronization, on the detection of mediastinal nodes (which are known to be less well detected by mri) compared to pet.


Eligibility criteria:
inclusion criteria: * at least 18 years, * neoplasia bronchopulmonary (sclc and nsclc) newly diagnosed, * patient potentially eligible for curative treatment, but no no treatment started, * patients for whom a pet scan and mri are planned non inclusion criteria: * claustrophobia, * implantable medical device * not compatible pacemaker type or heart valve, metal splinters eye) * pregnant or lactating women,
traumatic intracranial hemorrhage in users of oral antithrombotic drugs

Conditions: Intracranial Hemorrhage, Traumatic; Embolism and Thrombosis; Hematoma, Subdural, Intracranial

Summary: oral antithrombotic medications (oam) are used for the prevention and treatment of thrombotic disorders. among hemorrhagic complications of oams, intracranial hemorrhage (ich) may have particularly devastating consequences with high morbidity, disability and mortality rates. the efficacy and safety profiles of oams are generally assessed in randomized controlled trials (rct), but included patients are often highly selected and may not be representative of users in everyday clinical practice in terms of follow-up routines, age, gender, drug compliance, and polypharmacy. moreover, it is often unclear whether or not traumatic ichs are registered and reported in rcts. drifts in indications and treatment criteria may also be seen in everyday practice and drug discontinuation due to precautionary concerns including compliance, fall risk and comorbidity may be forgotten. collectively, these factors may lead to other and potentially higher traumatic ich rates in general clinical use than reported in rcts. the incidence rates of traumatic ich in patients on oams in the general population remain unknown. in this nationwide registry based pharmacoepidemiological study we will investigate the incidence and case fatality of traumatic ich in users of oams in norway from 2008 through 2014.


Eligibility criteria:
inclusion criteria: * included in the norwegian patient registry (npr) and/or the norwegian prescription database (norpd) exclusion criteria: -

Keywords: fibrinolytic agents adverse effects norway registries
family involvement in icu

Conditions: Intensive Care Patients; Relatives; Delirium in the Intensive Care Unit; Sedatives; Family

Summary: the aim of this prospective cohort study was to investigate the effect of the time spent with relatives of patients treated in a tertiary intensive care unit on patient outcomes. the main question it aimed to answer was: does spending more time with relatives of patients in intensive care result in lower sedative agent requirements? does spending more time with relatives of patients in intensive care result in less delirium, fewer ventilator days, and shorter icu stays?


Eligibility criteria:
inclusion criteria: * patients aged 18 and over. * patients with at least one family member actively involved in the care process in the icu. exclusion criteria: * patients with pre-existing cognitive impairment or dementia. * patients with severe traumatic brain injury. * patients with an expected mortality in the icu of more than 80%. * absence of family members for patients admitted to the icu.

Keywords: intensive care patients relatives delirium in the intensive care unit sedatives
effect of carotid ultrasound-guided fluid management on anesthetic-induced hypotension in elderly patients undergoing gastrointestinal surgery

Conditions: Hypotension on Induction

Summary: the goal of this clinical trial is to learn about whether carotid ultrasound guided fluid management can reduce the incidence of hypotension after general anesthesia induction in elderly patients undergoing gastrointestinal surgery. the main question\[s\] it aims to answer are: whether fluid therapy reduces the incidence of general anaesthesia induced hypotension in elderly patients undergoing gastrointestinal surgery. whether carotid ultrasound can guide fluid management in elderly patients undergoing gastrointestinal surgery. participants will use carotid ultrasound to assess volume status. if volume is insufficient, fluid therapy will be selected until volume is sufficient, anesthesia will be then induced. if volume is sufficient, anesthesia will be directly induced. there is a comparison group: no carotid ultrasound will be used to assess the volume status of the patients, and anesthesia will be directly induced.


Eligibility criteria:
inclusion criteria: * age 60-80 years old * gender unlimited * asa: grade i-ⅲ * bmi:18-30kg/㎡ * patients undergoing elective gastrointestinal surgery under general anesthesia informed consent exclusion criteria: * carotid artery stenosis ≥50% * patients with heart valve disease * patients with left ventricular ejection fraction \< 50% * patients with cardiac dysfunction (nyha grade ⅲ-ⅳ and/or ntprobnp≥900pg/ml) * patients combined with renal insufficiency (creatinine ≥178μmol/l, and/or blood urea nitrogen \> 9mmol/l) * preoperative systolic blood pressure\> 160mmhg or diastolic blood pressure \> 100mmhg * refuse to participate in the test * patients participating in other clinical trials
intravenous versus oral iron in late pregnancy: results of treatment

Conditions: Anemia; Pregnancy Complications

Summary: the purpose of this study is to compare the efficacy of body iron storage replenishment between low dose intravenous iron and oral iron in late pregnancy.

despite routine antenatal oral iron supplementation, the prevalence of iron deficiency anemia (ida) in the 3rd trimester of pregnancy in developing countries remains high. apparently, intravenous iron sucrose appears to be safe and efficient in treating within a short period. from literature review, no study of intravenous iron for ida treatment has been carried out in the third trimester of pregnancy. this research aims to compare the efficacy of body iron storage replenishment at 3 weeks as labor may take place at this point in some women. in this study,500 mg intravenous iron has been given weekly instead of every other day for the sake of patient's convenience in the hope that parenteral iron may become another alternative for treatment of pregnant women with iron deficiency anemia who have difficulties or failures with oral iron.

Eligibility criteria:
inclusion criteria: 1. age 18-45 years old 2. singleton pregnancy at 32 weeks gestation 3. having anemia in the third trimester according to world health organization, namely, with a hemoglobin level of \< 11 g/dl or hematocrit of \< 33% 4. having no underlying disease such as hypertension, gestational diabetes mellitus, heart disease, peptic ulcer, etc. 5. having no history of allergy to iron containing medication 6. having no history or other allergic conditions or asthma 7. having no thalassemia disease, for examples: b thalassemia major, hemoglobin e/ b thalassemia, homozygous hemoglobin e, hemoglobin h, ae bart disease, and ef bart disease. pregnant women who have iron deficiency anemia and are thalassemia carriers such as a-thalassemia 1, b-thalassemia, or less severe hb e/ b thalassemia are able to enter the study. 8. having no history of bleeding tendency 9. having no history of blood transfusion within the prior 120 days 10. having no history of delivery before 36 weeks gestation 11. giving consent and having signed the consent form for this study exclusion criteria: 1. stool exam revealed parasitic infestation 2. c-reactive protein \> 3 mg/l 3. serum ferritin \> 15 mcg/l

Keywords: iron deficiency anemia pregnancy third trimester intravenous iron efficacy a randomized trial female ferric compounds/therapeutic use* infusions, intravenous hematologic/therapy*
transfacial sutures versus stapler for mesh fixation in laparoscopic ventral hernia repair

Conditions: Ventral Hernia; Pain

Summary: hernia of the abdominal wall occur frequently after various surgical procedures of the abdomen and are increasingly performed by laparoscopic means. different mesh fixation techniques are applied, but the influence of mesh fixation on shrinkage is not known in human patients. therefore, mesh shrinkage was assessed using two different techniques for fixation.

ventral hernia repair is increasingly performed by laparoscopic means. while mesh ingrowth and shrink-age has been analysed in the experimental setting, there is scarce data available in humans. in addition, different mesh fixation techniques are applied, but the influence of mesh fixation on shrinkage is not known in human patients. mesh shrinkage is assessed using two different techniques for fixation. blinded randomized trial using a parietene composite mesh for laparoscopic ventral hernia repair. patients with ventral hernias of no larger than 8 cm were assigned to either mesh fixation using transfacial nonabsorbable sutures or titan tacks. primary endpoint was mesh migration, secondary endpoints were mesh shrinkage, surgical morbidity and pain.

Eligibility criteria:
inclusion criteria: * patients with incisional hernia smaller than 8cm in diameter * obtained informed consent exclusion criteria: * pregnancy * residual intraperitoneal mesh * contaminated abdominal cavity * longterm use of corticosteroids and other immunosuppressive agents * bodymass index \> 45 * general contradictions for laparoscopy

Keywords: ventral hernia laparoscopy mesh recurrence
dosing vancomycin in patients on sustained low efficiency daily hemodiafiltration (sledd-f)

Conditions: Acute Renal Failure

Summary: 1. sustained low efficiency daily hemodiafiltration(sledd-f) is a kind of renal replacement therapy with high-flux dialyser membrane (helixone). 2. the pore size of helixone is larger than most antibiotics, and vancomycin is supposed to be removed during dialysis. 3. our study wants to find the amount of vancomycin removed during sledd-f, and try to find the most appropriate dose regimen for this kind of patients.

vancomycin is the most important antibiotic in the treatment of resistant g(+) bacteria infections. close monitor of serum level is important to ensure its safety and effectiveness. so far there is not enough data to support the optimal dose regimen of vancomycin in patients on sledd-f. in this study, we draw blood levels between 2 doses of vancomycin to determine the pharmacokinetic parameters of vancomycin and fraction removed by sledd-f so as to determine the most appropriate dose regimen.

Eligibility criteria:
inclusion criteria: * acute renal failure of any cause * use sledd-f as renal replacement therapy * priscribe vancomycin for a known or suspected infection exclusion criteria: * none

Keywords: vancomycin, sledd-f
detection of ikzf1 deletion mutation in patients with acute lymphoblastic leukemia and its impact in therapy

Conditions: ALL, Childhood

Summary: 1. to detect ikzf-1 deletion mutations in patients with all. 2. to study the impact of ikzf-1 deletion mutation on therapy of all. 3. to study the correlation between ikzf-1 deletion mutations and bcr-abl.

acute lymphoblastic leukemia (all) a malignant transformation and proliferation of lymphoid progenitor cells in the bone marrow, blood and extramedullary sites. while 80% of all occurs in children, it represents a devastating disease when it occurs in adults . predisposing factors include exposure to ionizing radiation, pesticides, certain solvents or viruses such as epstein-barr virus and human immunodeficiency virus. however, in the majority of cases, it appears as a de novo malignancy in previously healthy individuals. chromosomal aberrations are the hallmark of all, but are not sufficient to generate leukemia. characteristic translocations include t(12;21) \[etv6-runx1\], t(1;19) \[tcf3-pbx1\], t(9;22) \[bcr-abl1\] . more recently, a variant with a similar gene expression profile to (philadelphia) ph-positive all but without the bcr-abl1 rearrangement has been identified. in more than 80% of cases of this so-called ph-like all, the variant possesses deletions in key transcription factors involved in b-cell development including ikaros family zinc finger 1 (ikzf1) . ikzf1 codes ikaros, which is a member of a family of zinc- finger nuclear proteins that is required for the earliest stages of lymphoid lineage commitment and acts as tumor suppressor. most ikzf1 mutations (94%) are deletion mutations, and there are rare point mutations resulting in loss of function of ikaros . there are two major deletions occur in the ikzf1 gene: * the first one was characterized by loss of exons 4 to 7 ( 4-7) with breakpoints occurring in introns 3 and 7 on chromosome 7p12. * the second deletion involved exons 2 to 7 ( 2-7) with a variable pattern of breakpoints in intron 1 and intron 7 in the same region as those of the 4-7 deletion. ikzf1 mutations in cases of b-all are associated with poor prognosis and high risk of relapse. ikzf1 mutations are found in approximately 15% to 20% of pediatric b-all cases and in \>75% of pediatric bcr-abl positive all cases. the incidences of ikzf1 mutations in adults are approximately 50% in b-all cases and approximately 65% in bcr-abl positive all cases . the presence of either ikzf1 mutation or bcr- abl has been reported to be an independent risk factor of poor prognosis for patients with b-all .

Eligibility criteria:
inclusion criteria: * patients with acute lymphoblastic leukemia. exclusion criteria: * patients with any other hematological malignancies. * patients receiving chemotherapy.
urinary retention after vaginal delivery with epidural anesthesia.

Conditions: Urinary Retention

Summary: the investigators intend to compare the rate of urinary retention among female patients after vaginal delivery under epidural anesthesia, depending on bladder catheterization type, either by a foley catheter inserted adjacent to epidural anesthesia or intermittent catheterization applied every 4 hours during labor.

an explanation about the study will be delivered to each participant and each participant will sign a confirmed consent. patients will be randomized between 2 groups of treatment: 1. intermittent catheterization applied every 4 hours during labor. 2. foley catheter inserted adjacent to epidural anesthesia. in patients with a foley catheter, the catheter will be removed soon after delivery. participants will be followed by a clinician post labor. an abdominal us will be performed either 4 hours after delivery or after the participant urinates to check the bladder volume. patient information including demographic information, information regarding the patient's pregnancy and delivery will be collected from the patient's electronic record.

Eligibility criteria:
inclusion criteria: * female patients in labor designated for vaginal delivery with epidural anesthesia. exclusion criteria: * patients with neurological problems including gestational diabetes. * patients either designated for elective cesarean delivery or emergent cesarean delivery.
effect of vitamin d supplementation on the metabolic control and body composition of type 2 diabetes subjects in ajman (uae)

Conditions: Type 2 Diabetes Mellitus; Obesity; Hypovitaminosis D

Summary: the incidence of type 2 diabetes mellitus and obesity is increasing at an alarming rate both nationally and worldwide. accumulating evidence suggests that serum cholecalciferol levels may be inversely related to the prevalence of diabetes, insulin resistance and metabolic syndrome. however, to demonstrate a causal relation between vitamin d and glucose metabolism, evidence from randomized and adequately powered placebo-controlled intervention trials is needed.the trials available on the effect of vitamin d supplementation are not conclusive. hence, the purpose of this study was to conduct a double-blind randomized trial in vitamin d deficient obese type 2 diabetic emirati population to clarify the effect of vitamin d supplementation on glycemic control and obesity parameters.

vitamin d insufficiency has been reported as a risk factor for the development of type 1 and type 2 diabetes mellitus. in contrast to the findings of the observational studies, the supplementation trials in type 2 diabetes mellitus (t2dm) do not report any definitive conclusions, but it does suggest that supplementation at an early stage in the development of diabetes may be of benefit in delaying progression to clinical t2dm by increasing the pancreatic insulin release and improved insulin resistance plus impaired glucose tolerance.there is also speculation on role of vitamin d in physiology of weight loss and body composition.however, there have been multiple inconsistencies within the reported trial i.e. sample size, dose of vitamin d, frequency of supplementation, and population studied. hence the randomised clinical trial was undertaken to study the effect of vitamin d (cholecalciferol) supplementation on metabolic markers and obesity parameters in the vitamin d deficient obese type 2 diabetic subjects.

Eligibility criteria:
inclusion criteria: * united arab emirates national * male or female * age 30-65 years * diagnosed as type 2 diabetes * body mass index ≥30 kg/m2 * serum 25 hydroxy vitamin d ≤ 50nmol/l exclusion criteria: * type 1 diabetes mellitus * history or evidence of liver failure (elevated liver function tests) or renal failure ( elevated creatinine) * history of malabsorption syndrome. * on vitamin d supplementation * on hormone replacement therapy * on corticosteroids, anticonvulsants, aids medication

Keywords: type 2 diabetes mellitus vitamin d cholecalciferol obesity
construction and validation of a stress scale specific to icus: perceived stressors in intensive care units (ps-icu)

Conditions: Work Stress

Summary: this study aims to construct and validate an international professional perceived stress scale specific to intensive care units: the ps-icu scale (perceived stressors in intensive care units).

intensive care units take charge of patients who present serious pathological states with an immediate vital risk in an emergency situation. their treatment requires extensive coordination of human means and sometimes the use of complex procedures and technical means. moreover, caregivers face the extreme situations of patients and their families coping with death, illness, pain and uncertainty (weibel et al., 2003). in this context, numerous stress factors that can have psychological consequences on the professionals and their effectiveness at work are inherent in intensive care (donchin, 2002; tummers et al., 2002). in numerous studies, perceived stress proves to be more predictive of the subsequent health state of the individual than real stress (consoli et al., 2001). more precisely, the authors have shown the influence of perceived stress on mental health (ramirez et al., 1996b), psychical health (chang et al., 2007), burnout (bourbonnais et al., 1999), job dissatisfaction (golbasi et al., 2008), absenteeism (hackett \& bycio, 1996), turnover (hayes et al., 2006) and more recently on the security of care (endacott, 2012). identifying the factors of perceived stress is important in terms of mental health at work and the security of care. studies on perceived stress have made it possible to elaborate stress scales specific to each profession (borteyrou et al., 2013), with the aim of being as close as possible to the professionals' experience. however, to our knowledge, no stress scale for intensive care units has been published. this study aims to construct and validate an international professional perceived stress scale specific to intensive care units: the ps-icu scale (perceived stressors in intensive care units). secondary objectives: to identify the factors of perceived stress having an impact on mental health, job satisfaction and the quality of care. to measure the impact of cultural and organizational dimensions on perceived stress in intensive care specific to each country. to measure the impact of socio-demographic variables on perceived stress. to measure the impact of coping abilities on perceived stress.

Eligibility criteria:
inclusion criteria: * in this step, we will include the services which: * practise an activity of intensive care (whether this practice is medical or surgical, adult or paediatric). the professionals of icu who: * volunteer to participate in the study (and with the consent of the head of the unit), * senior physicians, interns, and nurses who have been working in the service for more than three months. exclusion criteria: administrative staff, nursing auxiliaries * senior physicians, interns, and nurses who have been working in the service for less than three months.

Keywords: stress factors, intensive care units, scale, quality of care
survey on the current status of ifd diagnosis and treatment by intensive care physicians in sichuan province (ifs)

Conditions: Invasive Fungal Infections

Summary: the goal of this survey is to learn about the current status of the diagnosis and treatment of invasive fungal infections among intensive care physicians in sichuan province (ifs). its primary focus lies on answering the following questions: ①awareness and proficiency in diagnosis and treatment; ②the use of antifungal medications; ③the application of microbiological identification and diagnostic methods. we aim to analyze the problems and deficiencies that existed among intensive care physicians in order to provide a basis for the development of targeted training and intervention measures.


Eligibility criteria:
inclusion criteria: * intensive care physicians in medical institutions at all levels in sichuan province exclusion criteria: * exclude non-sichuan physicians. * excluding physicians who are not engaged in intensive care unit.
remote wheelchair skills training efficacy

Conditions: Spinal Cord Injuries

Summary: the objective of the study is to evaluate the effectiveness of remote training to teach clinicians how to train others in wheelchair skills.


Eligibility criteria:
inclusion criteria: • age 18 to 75 exclusion criteria: • upper or lower extremity injury that would preclude the ability to use a wheelchair.

Keywords: quality of life participation training
predicting platelet count from viscoelastic testing

Conditions: Thrombocytopenia

Summary: viscoelastic testing is a highly recommended cornerstone of modern coagulation medicine, reducing transfusion needs. a disadvantage of viscoelastic tests is the impossibility of making a definitive statement about the platelet count. therefore, the aim of this retrospective observational study is, on the one hand, to predict the platelet count based on standard rotem parameters with the help of several machine learning methods and, on the other hand, to detect a low platelet count ( \<100000 ml-1 and \< 50000 ml-1).


Eligibility criteria:
inclusion criteria: * rotem measurement and platelet count measurement within 3 hours. exclusion criteria: * under 18 years * more than 3 hours between rotem and platelet count measurement