Kornimate/medical-research-clean huggingface dataset:
improving patients' adherence to their chronic treatments by implementing a simple, standardized and redundant message delivered by healthcare professionals.

Conditions: Chronic Disease; Therapeutic Adherence; Training Group, Sensitivity; Delivery Simple, Standardized & Redundant Message to Patient

Summary: the primary objective in this study is to achieve a 15% 6-month improvement in therapeutic adherence among patients with chronic pathologies, thanks to a simple, standardized and redundant message delivered by healthcare professionals during consultations/interviews trained healthcare professionals deliver a simple, standardized and redundant 3-point message to patients, based on the levers of action concerning therapeutic adherence. this message is delivered with the aim of modifying the patient's behavior with regard to treatment intake.

this project will enable us to adapt or even modify the practices of healthcare professionals, by making management recommendations to improve patients' adherence to treatment during their consultations/interviews, and throughout their entire course of care. this project will increase the benefit/risk ratio of treatments and reduce the waste of healthcare resources. for patients, their participation by filling in the therapeutic adherence self-questionnaire will enable them to become active players in the management of their treatment. if the results of our study prove positive, this will lead to a new, optimized organization of patient care.

Eligibility criteria:
inclusion criteria: * adult patients (age ≥ 18 years) * affiliated to the french social security system * followed in hospital for a chronic pathology within a formalized care pathway * having signed a consent form to participate in the study. exclusion criteria: * patients included in the control period. * patients under guardianship. * pregnant or breast-feeding patients. * patients taking part in research on compliance

Keywords: intervention study stepped wedge study
mandibular ridge splitting versus khoury shell technique

Conditions: Horizontal Augmentation of Atrophic Posterior Mandible

Summary: mandibular ridge splitting with complete separation of the buccal cortical plate versus khoury shell technique for horizontal augmentation of atrophic posterior mandible


Eligibility criteria:
inclusion criteria: * patients with atrophic mandible with residual bone width 3 to 4 mm. * both sexes. * no intraoral soft and hard tissue pathology * no systemic condition that contraindicate implant placement. exclusion criteria: * • any pathology in the posterior mandible. * heavy smokers more than 20 cigarettes per day. * patients with systemic disease that may affect normal healing. * psychiatric problems * disorders to implant are related to history of radiation therapy to the head and neck neoplasia, or bone augmentation to implant site.
violence against women and consequences during climacteric´s phase

Conditions: Violence; Battered Women; Cognitive Behavior Therapy

Summary: objective- analysis of the health status of women who were or are victims of domestic and sexual violence seeking attention at the outpatient clinic for endocrines gynecology and climactery - university of sao paulo general hospital. to widen the comprehension of the binomial relationship violence-pathologies by professionals/staff who work in health services, offering women in such situation humane, comprehensive and qualified attention. specific objectives: decreasing the rates of domestic and sexual violence against women employing: prevention, health education and treatment - within the context of health services and public policies. methodology - project type: research in action a- attention to women in a situation of domestic and sexual violence during climactery; b- information/education/communication (iec) c- behavioral intervention (ic) d- institutional development (di). target populations: 1. women (during the ages of 40 to 65 years) who were or are victims of domestic and/or sexual violence; 2. professional/staff who work in services attending women in sexual and domestic violent situations (health professionals, policemen, civil society) in areas located within the south regional health coordination - src. to collect information, a semi structured questionnaire will be employed during seven months in 2009.

trained professionals will work in the regions of: campo limpo, m'boi mirim, santo amaro and neighboring regions, neighborhood in which the social vulnerability index of são paulo (ipvs) shows high records.

Eligibility criteria:
inclusion criteria: * women (during the ages of 40 to 65 years) who were or are victims of domestic and/or sexual violence exclusion criteria: * women who were not victims of domestic and/or sexual violence. * women that were not 40 to 65 years.

Keywords: domestic and sexual violence menopause professional improvement social support network
testing counseling styles to motivate smokers to quit

Conditions: Smoking; Tobacco Use; Nicotine Dependence

Summary: the purpose of this study is to determine, among a sample of general adult smokers, the effectiveness of three different counseling interventions for motivating quit attempts among smokers not yet ready to quit.


Eligibility criteria:
inclusion criteria: * age 18 years and older * smoke at least once a day for the past 30 days * are willing to participate in all study components * sufficient language skills in english for counseling and assessments * has a home address * has a working phone number exclusion criteria: * pregnant or planning to become pregnant in the next 6 months * currently using a smoking cessation medication * currently participating in smoking cessation program * motivated to quit smoking * planning to quit smoking in the next 2 weeks * lives in a home with someone currently enrolled in the study * minor

Keywords: smoking smoking cessation nicotine dependence tobacco use cessation health education patient education
prevalence of tongue anomalies in egyptian children

Conditions: Tongue; Anomaly

Summary: the purpose of the study is to determine the prevalence of tongue anomalies in a group of egyptian children and to relate the presence of malocclusion in cases of macroglossia, tongue tie and microglossia.

the tongue is an important and accessible muscle in the oral cavity, it has many functions which includes speech, chewing, swallowing, sucking, control of breathing, growth and developments of the jaws and perception to pain. also, many systemic disorders and diseases affect the tongue which makes it a great reflector of the general health. tongue anomalies has different frequencies and prevalence between different countries, these differences may be due to geographic, ethnic, gender and age variability, for example a study in iran in 2003 found that the prevalence of tongue anomalies 34.3%, while another study in colombia in 2013 found that the prevalence of tongue anomalies on their study population was 79.9%. the knowledge of the prevalence of tongue anomalies among egyptian children is missing in the literature which could compromise the quality of dental care, increase the occurrence of orthodontic problems and decrease the chances of early detection of some systemic diseases, since tongue anomalies could help in early determination of some systemic diseases in cases of fissured tongue and geographic tongue as well as early prevention and early intervention of malocclusions and speech defects that might be caused in cases of microglossia, macroglossia and ankyloglossia. hence, the knowledge of prevalence of tongue anomalies among egyptian children can aid in setting a reference which will then help in public health planning and prevention policies.

Eligibility criteria:
inclusion criteria: * participants' age between 6-12 years. * co-operative child * positive participants' acceptance for participation in the study. * participants having responsible care giver answered by approval on the previously sent informed consent which describes the aim \& importance of the study exclusion criteria: * patients with history of significant medical conditions * participants undertaken anti-fungal drugs in the previous 12 months

Keywords: tongue anomalies ankyloglossia fissured tongue geographic tongue macroglossia
use of wearables to detect infections in kidney transplant recipients

Conditions: Kidney Transplant Infection

Summary: the goal of this observational study is to develop a machine learning algorithm for early detection of infections in kidney transplant recipients using data recorded by wearable digital health technologies. the main questions it aims to answer are: 1. what are the biometric data pattern changes in impending infections? 2. what accuracy the machine learning algorithm can achieve? participants will be given/use their own wearable device that will record biometric data. any infection event will be recorded and an algorithm will be trained to recognize changes in biometric data preceding symptomatic infection.


Eligibility criteria:
inclusion criteria: * kidney transplant recipient * age 18 years or more * kidney allograft function (egfr based on ckd-epi more than 15ml/min/1.73m2) exclusion criteria: * recipient of another transplanted organ * terminal failure of another organ (heart, liver, lung) * diabetes mellitus type 1 * pregnant or breastfeeding woman * refusal to give informed consent

Keywords: biometric data continuous monitoring machine learning early alert system infection kidney transplantation
long-term follow up local registry study of kymriah in south korea

Conditions: B-Cell Acute Lymphoblastic Leukemia, Diffuse Large B-Cell Lymphoma, Follicular Lymphoma

Summary: this study is multicenter, primary data collection, non-interventional registry study to assess long-term safety, secondary malignancy risk, and effectiveness of tisagenlecleucel in patients with b-cell malignancies in a routine clinical practice setting in korea.

this study will inform on long-term real-world safety and effectiveness of tisagenlecleucel. the primary objective is to evaluate the long-term safety and the risk of secondary malignancies in patients with b lymphocyte malignancies treated with tisagenlecleucel in a real-world setting. the main secondary objective is to evaluate the longterm effectiveness of tisagenlecleucel. all participants enrolled in this study will be followed up for 15 years from the time of kymriah® infusion.

Eligibility criteria:
inclusion criteria: 1. patients who receive tisagenlecleucel infusion in the commercial setting, treated under a managed access program or other pathway, e.g., when product was manufactured for the commercial setting but turned out to be out of specification (oos). 2. consented to data collection. exclusion criteria: 1. patients who are enrolled or will be enrolled in the novartis long term follow-up protocol cctl019a2205b.

Keywords: b-lymphocyte malignancies b-all dlbcl fl tisagenlecleucel south korea
a randomized evaluation of the effect of routine normal saline flush versus heparinized saline solution in groshong and groshong picc catheters

Conditions: Catheters, Indwelling; Thrombosis

Summary: the groshong and groshong picc catheters are popular venous access devices because they are maintained with only weekly saline flushes. in a recent study, however, we found an apparent decrease in the rate of withdrawal occlusion in groshong catheters flushed weekly with heparinized saline. however, a randomized trial is necessary to confirm this impression. in the current study as many as 66 patients will be randomized to each of two treatment arms. the groshong catheters of one group will be flushed with saline only and the other group with heparinized saline. a comparison will be made between the frequency with which urokinase is used in the two groups to treat withdrawal occlusion during the first three months of catheterization. groshong catheters using saline flushes will be compared to groshong catheters using heparinized saline flushes and groshong picc catheters using saline flushes will be compared to groshong picc catheters using heparinized saline flushes. data will be analyzed using fisher's exact test.

the groshong and groshong picc catheters are popular venous access devices because they are maintained with only weekly saline flushes. in a recent study, however, we found an apparent decrease in the rate of withdrawal occlusion in groshong catheters flushed weekly with heparinized saline. however, a randomized trial is necessary to confirm this impression. in the current study as many as 66 patients will be randomized to each of two treatment arms. the groshong catheters of one group will be flushed with saline only and the other group with heparinized saline. a comparison will be made between the frequency with which urokinase is used in the two groups to treat withdrawal occlusion during the first three months of catheterization. groshong catheters using saline flushes will be compared to groshong catheters using heparinized saline flushes and groshong picc catheters using saline flushes will be compared to groshong picc catheters using heparinized saline flushes. data will be analyzed using fisher's exact test.

Eligibility criteria:
adult subjects enrolled in approved protocols of the nci in the cc or under treatment at the national naval medical center who are planned to have groshong catheters used as part of their cancer treatment. no subjects with a history of allergy to heparin. no abnormal pt or ptt. no subjects on anticoagulant therapy. no history of heparin induced thrombocytopenia.

Keywords: groshong catheter heparinized flush solution intraluminal clot urokinase venous access device withdrawal occlusion
retrospective analysis for patients with metabolic syndrome

Conditions: Metabolic Syndrome

Summary: the incidence of metabolic syndrome and related diseases is gradually increasing, and diet and medication are currently common outpatient treatment methods. this study retrospectively analyzes the clinical data of patients with metabolic syndrome and related diseases who have visited our outpatient department in the past 10 years, compares the therapeutic effects of different treatment methods on their blood glucose, blood lipids, blood pressure, uric acid, and body composition, and provides evidence support for clinical treatment.


Eligibility criteria:
inclusion criteria: • individuals who had at least a 2 follow up visits with a bmi of 24 or more with the pri-mary goal of losing weight. exclusion criteria: * patients did not follow-up on a monthly basis; * patients followed-up less than 1 times within 3 months; * patients having incomplete data; * patients changing their interventions during fol-low-ups
atrial late gadolinium enhancement in patients with repaired congenital heart disease

Conditions: Congenital Heart Disease; Fibrosis Myocardial; Fibrosis; Heart

Summary: in this research study the investigators want to learn more about how well the investigators can visualize scar tissue in the heart by mri. in patients with congenital heart disease who need a procedure in the electrophysiology laboratory, how the mri findings match the findings in the electrophysiology laboratory is not known. this study works to answer these questions. participants will undergo a cardiac mri as part of the routine clinical care that was ordered by their doctors and additional imaging by cardiac mri will be performed.

atrial arrhythmias including intra-atrial reentrant tachycardia (iart) and atrial fibrillation (af) routinely develop after surgical repair of congenital heart disease (chd), contributing to heart failure exacerbation, increased hospital resource use, and reduced health-related quality of life. the combination of atriotomy scars, intra-cardiac suture lines, and chronic pressure or volume overload from residual lesions creates the necessary milieu of heterogeneous atrial fibrosis capable of supporting wavefront reentry. while catheter ablation has become a primary tool in the management of iart and af, long-term ablation outcomes have stagnated over the preceding decade despite advances in mapping and ablative technologies. left atrial (la) fibrosis analysis using 3-dimensional (3d) late gadolinium enhancement (lge) cardiac magnetic resonance imaging (cmr) has shown utility in the management of adults with structurally normal hearts and atrial fibrillation (af), having associations with endocardial bipolar voltage amplitude, likelihood of maintenance of sinus rhythm after ablation, and thromboembolic risk. excellent reproducibility of la fibrosis quantification has been demonstrated in adults with structurally normal hearts and af. to date, the use of 3d lge in chd has been limited to the ventricles. prior studies have described altered la function in adolescent and young adult patients with rtof. additionally, right atrial (ra) functional abnormalities have also been described in patients with rtof. no prior studies have attempted to validate this technology in the atrium of patients with congenital heart disease. our studies aims to investigate the reproducibility of atrial fibrosis quantification by cardiac mri and may provide insights to correlations with voltage mapping in the electrophysiology laboratory.

Eligibility criteria:
inclusion criteria: * patients \>13 years old with congenital heart disease referred for cardiac mri and receiving gadolinium as part of routine clinical care or for pre-ablation planning will be included. exclusion criteria: * those with self-reported anxiety or claustrophobia and/or the presence of a permanent pacemaker or implantable cardioverter defibrillator will be excluded.

Keywords: late gadolinium enhancement 3d late gadolinium enhancement atrial late gadolinium enhancement cardiac mri congenital heart disease
cortical biomarkers of hand function and recovery after injury

Conditions: Stroke; Spinal Cord Injuries

Summary: this is a pilot study to collect data to support a va grant submission to study fmri and neurophysiological predictors of hand function and recovery during a robotic intervention in people with hand impairments due to stroke or spinal cord injury.

the loss of arm and hand function after cervical spinal cord injury (sci) limits independence and increases the cost of care. as a result, veterans with tetraplegia prioritize restoration of hand and arm function over all other rehabilitation goals. similar to sci, stroke of supraspinal areas involved in motor control results in acute movement deficits in more than 85% of survivors. despite advances in treatment and rehabilitation, 50% of stroke survivors have persistent hand impairment. the loss of hand function and dexterity limits the ability to perform many activities of daily living, and thus limits independence. since motor deficits are often permanent after sci and stroke, new strategies are needed to restore dexterous hand function. advances in functional imaging have enabled the measurement of finger-related activation patterns in somatosensory cortex, but little is known about how these representational patterns are impacted when hand function is lost. prior studies of gross movements have reported reorganization of cortical activity after injury. the investigators aim to improve dexterous hand function by increasing our understanding of finger-related cortical reorganization after lesions to the spinal or supraspinal structures. this understanding could allow discrimination between adaptive and maladaptive patterns underlying hand function and guide restorative therapies. additionally, imaging biomarkers of injury often track with functional recovery. the aim is to improve dexterous hand function by increasing our understanding of finger-related cortical reorganization after lesions to the spinal or supraspinal structures. this understanding could allow discrimination between adaptive and maladaptive patterns underlying hand function and guide restorative therapies. additionally, imaging biomarkers of injury often track with functional recovery.

Eligibility criteria:
inclusion criteria: * normal or corrected to normal vision * hand impairment due to spinal cord injury or stroke * weakness of fingers * one year after stroke or spinal cord injury * some proprioception (can feel when finger is moved, without seeing) * minimal spasticity exclusion criteria: * implanted metal with is unsafe for mri * pregnant or expecting to become pregnant * history of hand surgery which is under evaluation * cognitive or language issues that would interfere with following directions * other neurological disorder that would affect movement * history of seizure or epilepsy * body weight \> 300 pounds

Keywords: hand rehabilitation motor cortex
rapid molecular diagnosis of sepsis in the intensive care unit

Conditions: Sepsis; Bloodstream Infection

Summary: rapid diagnosis of sepsis is crucial for treatment and survival. currently, blood culture takes 48 hours-5 days to complete. after starting antimicrobial treatment blood culture results are not reliable. as a result, empirical broad spectrum antimicrobial therapy is mostly used. this implies possible antimicrobial over- or under treatment which is associated with increased antimicrobial resistance development. early identification of the causative pathogen of sepsis will therefore have a major impact on the adequate treatment and reduction of high mortality rates. to date, there is not a single molecular diagnostic test available on the market to detect all putative causative bacterial pathogens of sepsis. in this study, the investigators will develop and validate a completely new molecular sepsis approach based on pathogen dna detection, as an alternative to culture.


Eligibility criteria:
inclusion criteria: -patients are included when routine blood cultures are ordered for diagnosis of bloodstream infections. exclusion criteria: -n/a

Keywords: culture-free whole blood molecular diagnosis sepsis bloodstream infection bacterial dna
a study to evaluate the efficacy and safety of quadruple therapy (vx-222, telaprevir,peginterferon-alfa-2a, ribavirin) in subjects with chronic hepatitis c with compensated cirrhosis

Conditions: Chronic Hepatitis C Virus

Summary: the purpose of this study is to evaluate the safety and efficacy of a quadruple regimen (vx-222, telaprevir, pegylated interferon, and ribavirin)in subjects with hepatitis c with cirrhosis.


Eligibility criteria:
inclusion criteria: * subjects must have genotype 1 chronic hepatitis c * subjects must have compensated cirrhosis * subjects may either be treatment naïve, or may have received a course of peg ifn/rbv without evidence of response. subjects who are considered to be relapsers to peg ifn/rbv, or who are partial or null responders will be considered * subjects with hemophilia may be permitted to enroll with permission of the medical monitor exclusion criteria: * any previous treatment with an investigational drug or drug regimen for the treatment of hepatitis c, or previous treatment with an approved protease inhibitor * any contraindication to peg-ifn or rbv therapy * evidence of hepatic decompensation: history of ascites, hepatic encephalopathy, or bleeding esophageal varices * a history of acquired immunodeficiency infection, organ transplantation or have an ongoing requirement for immunosuppressive medicines