Kornimate/medical-research-clean huggingface dataset:
clinical study comparing submerged versus trans-mucosal healing of p.004 implants in the anterior mandible and maxilla

Conditions: Jaw, Edentulous, Partially

Summary: the purpose of this study is to demonstrate that there is no difference in change in bone level around p.004 implants between 1st stage surgery and 6 months post surgery when transmucosal implant placement is compared to submerged implant placement

the primary objective of this study is to determine the level at which the bone can be maintained in relation to the implant shoulder for the p.004 two-stage implant when placed in a submerged or a trans-mucosal procedure in single tooth gaps in the anterior region. the primary parameter will be measured by radiography 26 weeks after loading of the implant.

Eligibility criteria:
inclusion criteria: * males and females \>18 years of age. * implant placement planned in the anterior maxilla or mandible (fdi tooth numbers 21 - 25, 11 - 15, 31-35, 41-45). * tooth site must have a natural tooth both mesially and distally in the adjacent tooth positions * opposing dentition of natural teeth, or tooth or implant-supported fixed restorations. * adequate bone quality and quantity at the implant site to permit the insertion of a straumann p.004 slactive implant of 8, 10, 12, or 14 mm length. * presence of a sufficient band of keratinized mucosa (min. 2 mm) to allow surgical manipulation and suturing according to the protocol * signed informed consent document before being treated in the study exclusion criteria: * systemic disease that would interfere with dental implant therapy (e.g. uncontrolled diabetes) * any contraindications for oral surgical procedures * current untreated periodontitis or gingivitis * probing pocket depth of more than 4 mm at one of the adjacent teeth * mucosal diseases (e.g. erosive lichen planus) * history of local irradiation therapy * bone augmentation procedures if the procedure require healing time of more than 12 weeks after implant placement * implants in adjacent position to planned implant * severe bruxing or clenching habits * heavy smokers: patients who smoke more than 20 cigarettes per day * conditions or circumstances, in the opinion of the investigator, which would prevent completion of study participation. * patients with inadequate oral hygiene or unmotivated for adequate home care secondary exclusion criteria at implant surgery: * lack of primary stability of the implant * inappropriate implant position to insert implants according to the prosthetic requirements. * patients with augmentation procedures requiring more than 12 weeks healing time.

Keywords: dental implant
effects of dynamic taping on shoulder isokinetics strength and muscle fatigue.

Conditions: Dynamic Tape; Kinesio Taping; Strength; Fatigue

Summary: maintaining shoulder stability requires good neuromuscular control. imbalances in shoulder internal and external rotator strength may increase the risk of shoulder injuries in overhead athletes, and the compromised fatigue resistance of the external rotators may worsen this imbalance during sports activities. additionally, poor scapular neuromuscular control is associated with shoulder problems, such as shoulder impingement syndrome. previous research has shown that individuals with shoulder impingement syndrome exhibit poor scapular motion control and altered corticomotor control. poor scapular motion control, pain, functional impairment, and changes in corticomotor control interact to form a vicious cycle. various treatments have been attempted to improve neuromuscular control, including taping. most past studies have focused on the efficacy of rigid tape and kinesio tape, while dynamic tape has gained popularity in recent years. due to its material properties, dynamic tape is theoretically able to absorb loads, provide force, and correct movements. however, there is currently a lack of evidence supporting the effectiveness of dynamic tape. no research has yet explored whether dynamic tape can provide force to increase muscle strength and reduce fatigue or whether its movement correction functions can improve neuromuscular control and corticomotor control. therefore, this project plans to conduct an experiment to investigate the effects of dynamic tape on external rotator strength and fatigue in recreational overhead athletes, as well as its impact on neuromuscular control and corticomotor excitability in recreational overhead athletes with shoulder impingement syndrome. in the experiment, 37 healthy recreational overhead athletes will participate in three testing sessions spaced one week apart, receiving kinesio tape, dynamic tape, and sham tape. after taping, they will perform fatigue-inducing activities. isokinetic strength of internal and external rotators will be measured before taping, after taping, and after fatigue-inducing activities to observe the effects of dynamic tape on muscle strength and fatigue compared to kinesio tape and sham tape.


Eligibility criteria:
inclusion criteria: * practice overhead exercise more than six hours a week * aged 18 to 40 years old exclusion criteria: * have a history of dislocation, fracture, or surgery of neck or upper extremity * a history of pain or injuries over the neck or upper extremities within the past 12 months * brain injury and neurological impairment * arm elevation angle is less than 150 degrees
effect of contact lens wear on immune cell density and morphology of the ocular surface

Conditions: Myopia; Refractive Error

Summary: the purpose of this study is to utilize in-vivo confocal microscopy to describe differences in corneal epithelial immune status across three lens care regimens in new contact lens wearers.

an estimated 40 million people in the united states wear contact lenses, with approximately 38 million soft lens wearers and 2 million rigid gas permeable lens wearers. the ocular surface has been shown to respond to the introduction of foreign materials with upregulation of proinflammatory mediators, leading to an increase in inflammation. the corneal can show a foreign body immune response to contact lenses. the purpose of this study is to utilize in-vivo confocal microscopy to describe differences in corneal epithelial immune status across the three lens care regimens in new contact lens wearers.

Eligibility criteria:
inclusion criteria: 1. subjects must be 18 years of age and may be of any race and either gender. 2. subjects must not have ever worn contact lenses. 3. subjects must have normal, healthy eyes. exclusion criteria: 1. subjects must not use additional lens cleaners. 2. subjects must not have any ocular or systemic disease. 3. subjects must not have history of ocular surgery/trauma within the last 6 months.

Keywords: contact lens lens care
impact of cranberry juice consumption on gut and vaginal microbiota in post-menopausal women

Conditions: Urinary Tract Infections

Summary: this study was a randomized, placebo-controlled, crossover, pilot dietary intervention. ocean spray cranberries, inc provided the experimental and placebo beverages, which have been validated and used in previous studies \[26-29\]. both beverages were similar in appearance, taste, and aroma and assigned to volunteers according to computer-generated random orders. both investigators and participants were blind to the assignment and products are identified by a random 3-digit code pre-printed on the cap. the participants consumed either cranberry juice or placebo beverage daily (8 fl oz per day) for 15 days

this was a prospective exploratory pilot study with a dietary intervention. twenty-three (23) women volunteered and participated in this study. the eligibility (no menstrual period for at least 12 months) of the participants was determined using a questionnaire. the participants were postmenopausal women between the ages of 50-75 years old who met the exclusion criteria including no recent antibiotics or immunosuppressive therapies, surgery of the stomach, small or large intestines, appendectomy, gastric bypass or gastric banding in the previous 6 months, and diagnostic with any autoimmune diseases. this study was a randomized, placebo-controlled, crossover, pilot dietary intervention. ocean spray cranberries, inc provided the experimental and placebo beverages, which have been validated and used in previous studies \[26-29\]. both beverages were similar in appearance, taste, and aroma and assigned to volunteers according to computer-generated random orders. both investigators and participants were blind to the assignment and products are identified by a random 3-digit code pre-printed on the cap. the participants consumed either cranberry juice or placebo beverage daily (8 fl oz per day) for 15 days

Eligibility criteria:
inclusion criteria: * post-menopausal status exclusion criteria: * recent (6months) antibiotics or immunosuppressive therapies * recent (6months) abdominal surgeries
intraocular pressure (iop) changes associated with muslim prayer postural changes

Conditions: Glaucoma

Summary: elevated intraocular pressure is widely accepted as a risk factor for glaucoma and controlling the pressure remains the cornerstone of effective treatment. there is evidence that posture can have a significant effect on intraocular pressure fluctuations. salat (or salah) refers to the five daily prayers performed by muslims. the time spent praying in a kneeling or prostrate position may be associated with wide fluctuations in intraocular pressure, potentially sight-threatening for muslim patients with glaucoma. the researchers seek to investigate the link between traditional daily muslim prayer postural changes and intraocular pressure changes.


Eligibility criteria:
inclusion criteria: * diagnosed with primary open angle glaucoma * must be age 18 and up * provide written informed consent to participate * able to cooperate with ocular examination for 60-90 minutes * able to assume the standing, bowing, and prostrate positions exclusion criteria: * special patient populations (children, pregnant women, prisoners etc.) * patients who have had glaucoma surgery that could effect the change in intraocular pressure (ie trabeculectomy, tube-shunts, etc.) * patients who are unable to assume bowing or kneeling positions

Keywords: glaucoma intraocular pressure postural changes
randomized study comparing local tumor control after post-operative single-fraction or hypofractionated stereotactic radiosurgery in the treatment of spinal metastases

Conditions: Spinal Metastases

Summary: the purpose of this study is to find out whether giving one higher dose of radiation is as good at treating the tumor in the patient's spine after surgery as giving three lower doses of radiation.


Eligibility criteria:
inclusion criteria: * histologically diagnosed metastatic cancer (diagnosis made or confirmed at mskcc for mskcc participants. institutional pathologic determination accepted from participating multicenter sites.) * age ≥18 years * life expectancy ≥3 months * ecog ≤ 3 * spinal surgery carried out with the goal of spinal cord decompression and spinal stabilization within 8 weeks * post-operative ct myelogram or mri perfusion with evidence of separation of tumor and the spinal cord it should be noted that patients with multiple lesions will be eligible as long as there are no overlapping fields of radiation, including at various time frames. exclusion criteria: * primary spine tumor * age \< 18 * pregnancy * lack of adequate (≥ 2 mm) separation between the spinal cord and the tumor on post-operative ct myelogram or mri perfusion * radiosensitizing chemotherapy (taxol, taxotere, cisplatin, gemcitabine, 5-fluorouracil) given within one week of radiation treatment

Keywords: stereotactic radiosurgery (srs) single-fraction hypofractionated spinal surgery 14-233
the lifestyle education about prediabetes (leap) study

Conditions: PreDiabetes

Summary: this research will test whether a standard version or very low-carbohydrate version of the diabetes prevention program better improves outcomes like blood glucose control and body weight for patients with prediabetes. participants will have screening (includes blood draw) and baseline testing with a continuous glucose monitor. once these enrollment steps are completed and the participants will be randomized to one of two groups: standard national diabetes prevention program (ndpp) or a very low-carbohydrate version. in addition to the diet (12 months) participants will be asked to participate in hour-long weekly group classes over zoom. after four months in the program, classes will occur about every month to help participants maintain the new diet. there will also be check-ins and follow-up visits through out the study.


Eligibility criteria:
inclusion criteria: * overweight, defined as bmi \>= 25 kg/m2 \>= 23 kg/m2 if of asian descent * hba1c between 5.7% - 6.4% verified at baseline * willingness to participate in group-based sessions * able to engage in at least light physical activities such as walking * willingness to follow a prescribed diet, be randomized, self-weight, track diet, and report physical activity minutes * physician approval to participate exclusion criteria: * history of type 1 diabetes or type 2 diabetes * use of anti-obesity medications or participation in another weight loss program or intervention * use of glucose lowering medications other than metformin * pregnant or planning to become pregnant during the intervention period * breastfeeding * use of oral corticosteroids * previous bariatric surgery or planning to have bariatric surgery during the study period * blood disorders that influence hba1c, including frequent blood transfusions, phlebotomy, anemia, hemoglobinopathy, polycythemia * any condition for which the study team deems participation to be unsafe or inappropriate * inability to read, write, or speak english * inability to provide informed consent * adherence to a vegan or vegetarian diet * adherence to a very low-carbohydrate (keto) diet * difficulty chewing or swallowing * no influence over what foods are purchased, prepared, and/or served * above weight limit for dexa (500 pounds) * untreated eating disorder or mental health conditions, such as depression with suicidal ideation, bipolar or schizophrenia with psychosis * use of warfarin * chronic kidney disease, stage 4 or higher * use of loop diuretics: 20mg or higher of furosemide or equivalent (lasix (furosemide), bumex (bumetanide), ederin or sodium edecrin (ethacrynic acid), demadex or soaanz (torsemide)) * any concerning values in baseline labs (participants will be referred to primary care physician and will be allowed to return for later enrollment if labs are no longer concerning) * triglycerides 600 milligrams per deciliter (mg/dl) or higher * thyroid stimulating hormone of any abnormal value * potassium of any abnormal value

Keywords: very low carbohydrate diet diabetes prevention program nutrition therapy
study of pemetrexed in mesothelioma and lung cancer patients with fluid around the lungs or abdomen

Conditions: Non-small Cell Lung Cancer; Mesothelioma; Lung Neoplasms

Summary: this study will test the effects of pemetrexed on mesothelioma and non-small cell lung cancer patients with fluid around their lungs or abdomen.


Eligibility criteria:
inclusion criteria: * diagnosis of locally advanced or metastatic (stage iii or iv at entry) non-small cell lung cancer (nsclc) or mesothelioma * presence of third-space fluid (fluid around the lungs or abdomen). * eastern cooperative oncology group performance status of 0 or 1. * prior anticancer treatment (except radiation) must be completed at least 3 weeks prior to study enrollment, and the patient must have recovered from the sharp toxic effects the anticancer treatment. * estimated life expectancy of at least 8 weeks. exclusion criteria: * have received treatment within the last 30 days with a drug that was not a marketed product. * active infection that, in the opinion of the investigator, would not allow the patient to tolerate therapy. * pregnancy. * breast-feeding. * significant weight loss (that is, greater than or equal to 10% of body weight) over the 6 weeks before study entry. * brain metastases.
study on osseospeed™ implants in patients missing 2-5 teeth in the posterior lower jaw, restored with permanent teeth attached 6-7 weeks later

Conditions: Jaw, Edentulous, Partially

Summary: the purpose of the study is to evaluate astra tech dental implant system, fixture osseospeed™, in patients with tooth loss in the posterior mandible in an early loading protocol. primary objectives are implant stability, marginal bone adaptation and survival rate.


Eligibility criteria:
inclusion criteria: * provision of written informed consent * 18 years of age and over * edentulous in the posterior mandible, kennedy class i or class ii. last natural tooth, or previously restored implant in function is canine or first bicuspid. * deemed by the investigator as likely to present an initially stabile implant situation suitable for early loading exclusion criteria: * untreated caries and/or periodontal disease of residual dentition * history of edentulism in the area of implant placement of less than two months * current need for pre-surgical bone or soft tissue augmentation in the planned implant area. * history of pre-surgical bone or soft tissue augmentation, within12 months, in the planned implant area. * any systemic or local disease or condition that would compromise post-operative healing and/or osseointegration * need for systemic corticosteroids or any other medication that would compromise post-operative healing and/or osseointegration * present alcohol or drug abuse * unable or unwilling to return for follow-up visits for a period of 5 years * current use of smoking tobacco * pregnancy or lactation at the time of enrollment

Keywords: jaw, edentulous, partially (posterior mandible)
registry platform colorectal cancer

Conditions: Colorectal Cancer Metastatic

Summary: the registry aims to collect and analyse information on the antineoplastic treatment of patients with metastatic colorectal cancer, treated in palliative intention in daily routine practice in germany.

azurite is a national, observational, prospective, longitudinal, multicenter cohort study (tumor registry platform) with the purpose to record information on the antineoplastic treatment of metastatic colorectal cancer in germany. the registry will follow patients for up to three years. it will identify common therapeutic sequences and changes in the treatment of the disease. at inclusion, data in patient characteristics, comorbidities, tumor characteristics and previous treatments are collected. during the course of observation data on all systemic treatments, radiotherapies, surgeries, and outcome are documented. health-related quality of life (hrqol) will be evaluated for up to three years.

Eligibility criteria:
inclusion criteria: * patients with histologically proven metastatic colorectal cancer (stage iv) at time of inclusion (patients with metastatic disease and potential curative treatment intention are allowed) * age ≥ 18 years * planned first systemic therapy for metastatic disease * signed and dated informed consent form * patients participating in the pro module: prior to or at start of first systemic treatment for mcrc * patients not participating in the pro module: within four weeks after start of fist systemic therapy for mcrc exclusion criteria: * patient who do not receive any systemic therapy for mcrc * patients whose metastatic disease was surgically resected prior to inclusion and who start adjuvant chemotherapy
short-term clinical deterioration after acute pulmonary embolism

Conditions: Pulmonary Embolism

Summary: this is a prospective, observational, multicenter cohort study to compare right ventricular dysfunction dependent and independent prognostic models for short-term serous adverse events in patients who are diagnosed with pulmonary embolism in the emergency department. clinical endpoints are assessed at days 1-5. a thirty-day follow-up phone call is conducted to obtain further clinical endpoints and a quality of life assessment.

the objective of this study is to compare right ventricular dysfunction (rvd)dependent and independent prognostic models for short-term serious adverse events in pulmonary embolism (pe) patients. the target population is emergency department (ed) patients with confirmed acute pe within 12 hours of ed presentation. the primary outcome is a composite of death, delayed circulatory or respiratory dysfunction, hypoxia, and reperfusion intervention within five days of pe diagnosis. secondary outcomes will be nonfatal bleeding, recurrence of venous thromboembolism, and hypoxia requiring oxygen supplementation. the specific aims are: 1) determine the incidence of death, circulatory and respiratory deterioration, and administration of reperfusion therapy within five days of pe; 2) determine functional outcomes 30 days after pe using the pulmonary embolism quality of life questionnaire; 3) evaluate the sensitivity, specificity, and positive and negative likelihood ratios of each rvd assessment tool for clinical deterioration within five days of pe; and 4) derive a prediction model for clinical deterioration within five days of pe diagnosis. patients with confirmed pe will be assessed for hemodynamic stability at presentation, and then will be assessed for rvd. normotensive pe patients without rvd will be assessed by a clinically derived model (spesi or hestia) to determine if they are low risk or intermediate-low risk. the investigators will then determine incidence of the clinical endpoints during the subsequent 5 days, as well as 30 days later. the 30-day follow-up will also include administration of the validated pulmonary embolism quality of life questionnaire (pembqol).

Eligibility criteria:
inclusion criteria: * men and women, 18 years or older, with image confirmed acute pulmonary embolism diagnosed within 12 hours of ed presentation exclusion criteria: * patients who decline any participation in the study * patients 17 years old and younger at the time of screening * radiologist's over read that determines that filling defects identified as acute emboli are instead either chronic, resolving, or unchanged after comparison to previous ct, if available * if empiric anticoagulation or escalated intervention were initiated more than 12 hours before presentation to the recruiting ed * identification of either segmental or subsegmental intraluminal filling defects on ct that are considered to be clinically incidental and unrelated to primary diagnostic workup or ed presentation.

Keywords: right ventricle dysfunction prediction model functional outcomes