Kornimate/medical-research-clean huggingface dataset:
treatment of dowling maera type of epidermolysis bullosa simplex by oral erythromycin

Conditions: Epidermolysis Bullosa

Summary: dowling meara type of epidermolysis bullosa simplex (ebs-dm) is a rare genodermatosis due to keratin 5 and 14 mutation, characterized by skin fragility and spontaneous or post traumatic blisters. neonatal period and infancy are critical since this autonomic dominant affection usually improves with age. cyclins seem to be efficient in some cases of ebs but are prohibited in children younger than 8 years old. erythromycin can be a good alternative in this population due to its antibacterial and anti-inflammatory potential. the aim of this study is the evaluation of the efficiency of oral erythromycin to decrease the number of cutaneous blisters in severe ebs-dm patients from 6 months to 8 years old after 3 months of treatment. primary end point is the number of patients with decrease of blisters' number of at least 20% after 3 months of treatment by oral erythromycin. it is a preliminary study on 8 patients. treatment is oral erythromycin twice a day during 3 months. follow up for each patient is 5 months. the duration of the study is 1 year.


Eligibility criteria:
inclusion criteria: * severe dowling meara ebs patients (2 or more new blisters a day) * signature of informed consent * patient of 2 sexes * age from 6 months to 8 years. from this age we consider that the patient will less need this treatment or can take cyclines. * systematic obtaining of the consent lit(enlightened) by the relatives(parents) of the child, after information about the objectives and the constraints of the study. * agreement of the minor * patient member to the social security exclusion criteria: * patient allergic to the erythromycin * patient presenting an intolerance to the fructose, a syndrome of malabsorption some glucose and some galactose or a deficit sucrase-isomaltase * renal and\\or hepatic insufficiency * patient taking a medicine against indicated or misadvised in association with the erythromycin
a spanish-language intervention to enhance routine hiv patient care delivery [care+ spanish]

Conditions: HIV Infections

Summary: the purpose of this study is to see if a computer counseling tool helps spanish-speaking people living with hiv to have safer sex and to do well on their hiv medicines.

latinos are the fastest-growing group with some of the largest health disparities including hiv. barriers including language are associated with lower antiretroviral therapy (art) adherence seen among latinos. there are no evidence-based interventions (randomized trials that significantly reduced viral load and hiv transmission risk to sexual partners - 'positive prevention') delivered in spanish in routine clinical practice. our computerized counseling tool (care+) in a phase iii trial of english-speaking adults increased art adherence and reduced viral load and condom use errors. we now propose a longitudinal effectiveness (phase iv) study to evaluate the impact of computerized counseling in audio-narrated spanish in a busy urban hiv clinic. this 'care+ spanish' proposal is responsive to 06-od(obssr)-101, for new technologies to improve adherence in clinical practice. aim 1: adapt care+ spanish for use during routine clinical visits by spanish-speaking hiv clinic attendees using an expert panel to shorten content and add spanish audio dialects; do usability testing (n≤8). aim 2: establish real-world utility of 'care+ spanish'. peer staff will recruit spanish-speaking adults on art who will be randomly assigned to intervention (group a n=250) or risk-assessment control (b, n=250) for 0,3-,6-,9-month sessions; at 12-month session groups will switch to opposite arm (delayed intervention design). linear and generalized linear mixed effects models will analyze impact on 30-day art adherence, clinic visit adherence, hiv-1 viral load and sexual risks, and to assess whether any group a changes are sustained at month 12, among an expected n=400 retained study participants (120 female, 280 male). aim 3: explore cultural acceptability of tool among clients and clinic providers. conduct qualitative exit interviews with patients (n=75) to assess technology uptake factors, cultural/linguistic acceptability, and suggestions for ongoing use among older vs. younger, and us-born vs. foreign-born latino groups. conduct two focus groups with providers (n≤30) to assess perceived technology barriers/facilitators. analysis will identify factors affecting acceptability, utilization, and impact. technology tools like care+ present significant opportunities to bridge the health promotion delivery gap, especially if linguistically adapted for often-neglected groups such as latinos (15% of the us population).

Eligibility criteria:
inclusion criteria: * hispanic birth or ancestry * speaks spanish (mono- or multi-lingual) exclusion criteria: * lack of fluency in spanish * thought disorder that precludes participation * inability to give informed consent due to altered mentation at time of enrollment (e.g., visibly inebriated or high).

Keywords: hiv treatment art adherence using new technology to improve adherence care+ hiv-1 viral loads
distal radius fractures in patients over 65 years, operation or cast?

Conditions: Distal Radius Fracture

Summary: eligible patients that sign an informed consent will be randomized to operation with volar locking plate or cast immobilization. primary follow-up after 1 year.

the investigators want to investigate if there is a difference between operative treatment with volar locking plates and cast immobilization in patient above 65 years with unstable distal radius fractures ao/ota type a and c . eligible patients that meets the radiological criteria (see inclusion criteria) will be randomized to cast immobilization or operation with volar locking plate. the investigators are planning a non-inferiority design. the current study will test the following null hypothesis: in patients over 65 years of age with unstable distal radius fractures ao/ota type a and c,volar locking plates are superior to cast immobilization by more than 8 points, as evaluated by quick-dash at 12 months follow-up. the investigators will perform a cost-effectiveness analysis comparing qalys (quality-adjusted life years) and costs with the two interventions the first year of follow-up.

Eligibility criteria:
inclusion criteria: * ao/ota class a- and c-fractures * age \> 65 years * unacceptable primary reduction or redislocation \< 20 days post-injury with at least one of the following findings: * dorsal angulation \> 10 degrees * radial shortening \> 3 mm * intraarticular step-off \> 2 mm * ability to sign an informed consent * acute fracture, inclusion within 20 days from injury. * ability to reconstruct the articular surface with a volar locking plate exclusion criteria: * volar angulated fractures and ao type b * associated diseases contraindicating surgery * mental impairment, nursery home patient * earlier wrist injury * pathological fractures * open fractures (\>gustilo-anderson i) or damaged soft tissue * drug abuse * concomitant injuries that might affect outcome * congenital anomaly of affected extremity * median nerve compression that requires acute operation * foreign language * tourists
can psychotherapy reduce sickness absence?

Conditions: Mental Disorders

Summary: the purpose of this study is to examine if psychotherapy can reduce sickness absence.

sickness absence due to psychiatric problems is considered a growing problem in norway. little research is done to examine if psychotherapy can reduce sickness absence. since 2007 there is a government sponsored program in norway (raskere tilbake) aimed at reducing sickness absence. this study examines if psychotherapy within this program, delivered at an out-patient clinic, actually reduces sickness absence. levels of absenteeism is measured before, after and 6 months after treatment. this is a quasi-experimental study, where the treatment-group will be compared with a statistical group in the general population, that is socio-demographical similar and has similar history of sickness absence but haven't been to treatment. changes in levels of symptoms and quality of life will also be measured. the participants will be asked to describe their working environment, and this will be related to outcome-measures.

Eligibility criteria:
inclusion criteria: * patients receiving psychotherapy at lovisenberg dps/raskere tilbake exclusion criteria: -
a comparison of the outcomes of distal fingertip amputations treated with either artificial (xeroform) or biological dressings

Conditions: Finger Injuries; Amputation, Traumatic

Summary: this is a prospective study looking to evaluate whether the treatment outcomes for patients who sustain a distal fingertip amputation are improved or no different when using biological dressings versus artificial dressings.


Eligibility criteria:
inclusion criteria: * all individuals presenting at bellevue hospital for evaluation and treatment of a finger amputation distal to the germinal matrix that present along with the amputated distal fingertip unit. exclusion criteria: * replantation candidate, incomplete distal finger-tip amputation
exercise and rp (avamc and emory)

Conditions: Retinitis Pigmentosa

Summary: the purpose of this study is to look in humans at the relationship between moderate or little exercise and their potential effects on the retina in patients with retinitis pigmentosa (rp).

human studies have shown that regular exercise may have positive effects on common degenerative diseases such as alzheimer's disease. exercise has also shown to improve conditions the eye such as macular degenerations, glaucoma, and cataracts. mice with retinal degeneration which were exposed to exercise showed that it helped to slow the rate of degeneration. the purpose of this study is to look in humans at the relationship between moderate or little exercise and their potential effects on the retina in patients with retinitis pigmentosa (rp).

Eligibility criteria:
inclusion criteria: * visual field no less than 10 degrees; * va no worse than 20/200 in the better seeing eye. exclusion criteria: * not able to tolerate exercise due to an underlying medical condition.

Keywords: exercise quality of life progression of disease retinitis
prospective study of the sensitvt

Conditions: Stress Urinary Incontinence

Summary: sensitvt is a relatively new tape. the aim of this study is to analyze the objective and subjective outcome at one year follow-up.

stress urinary incontinence (sui) is defined as the involuntary leakage during physical activity and situations that result in an increase of abdominal pressure like sneezing, coughing or laughing and affects up to 25% of women. currently there are a number of tapes on the market with gynecare tvt exact® (tension free vaginal tape) and tvt- obturator being one of the tapes with the highest subjective and objective cure rates and relatively low adverse events in women with normal sphincter pressure. due to the recent fda announcements several tapes have been withdrawn from the market and several new ones have been designed. data from other tapes are available, however data especially from newer tapes is lacking.

Eligibility criteria:
inclusion criteria * planned surgery for verified predominant stress urinary incontinence * women between 18 and 80 years of age * good german language skills * informed consent exclusion criteria: * pregnant or lactating women * active surgical treatment for invasive malignant diseases within 3 months * contraindications for surgery or anesthesia * severe neurologic disease * concomitant prolapse surgery

Keywords: stress urinary incontinence objective outcome
decreased eeg complexity in schizophrenia

Conditions: Electrophysiological Randomness; Entropy

Summary: aim was to detect eeg complexity in a specific group of patients to contribute to the discussion whether schizophrenia is associated with increased or decreased complexity. we included the eeg recordings of patients with a diagnosis of schizophrenia. we hypothesized that chronic residual schizophrenia is characterized by decreased complexity in eeg.

twenty right-handed patients diagnosed with schizophrenia, residual subtype, by two senior psychiatrists according to the diagnostic statistical manual of mental disorders 4th edition (dsm-iv)were recruited from neuropsychiatry istanbul hospital. only patients scoring 4 or higher on the clinical global impression scale for severity (cgi-s) were included. they were assessed with the turkish version of the positive and negative syndrome scale. data was collected with a 16-channel neuroscan synamps ii (neuroscan products, compumedics, charlotte, nc, usa), silver-silver chloride electrodes were applied to the scalp surface according to the international 10-20 system

Eligibility criteria:
inclusion criteria: diagnosed with schizophrenia, residual subtype, by two senior psychiatrists according to the diagnostic statistical manual of mental disorders 4th edition (dsm-iv) were recruited from neuropsychiatry istanbul hospital only patients scoring 4 or higher on the clinical global impression scale for severity (cgi-s) exclusion criteria: -

Keywords: complexity electroencephalogram entropy negative symptoms schizophrenia.
adaptation of an ehealth (web-application) platform for delivery of a sedentary behavior intervention among prostate cancer patients

Conditions: Sedentary Lifestyle

Summary: the overall objective of this study is to adapt and refine an existing ehealth (web-application/web-app/app) platform designed to promote spontaneous movement (reducing sedentary behavior) among older adults, to men with prostate cancer.

primary treatments for prostate cancer (pca) accelerate aging-related changes in body composition and declines in physical function and quality of life ; the median age at pca diagnosis is 66 years and approximately 64% of pca survivors are \> 70 years. the negative side effects of treatments are pronounced in older, sedentary, overweight or obese men with existing comorbidities. the concomitant loss of skeletal muscle mass, increased deposition of adipose tissue and loss of bone mineral density leads to fractures, cancer-related fatigue, frailty, compromised physical functioning, disability and loss of independence as well as anxiety and depression. regular physical activity reduces morbidity, improves survival and can buffer pca patients against the negative side-effects of treatment, yet less than 20% are meeting recommended guidelines-and most spend up to 70% of their time each day in sedentary behavior. targeting a reduction in sedentary behavior by promoting regular spontaneous movement in conjunction with regular resistance training may be an effective approach for pca patients who are likely to be fatigued and functionally impaired. traditional theory-based exercise interventions have shown preliminary efficacy for promoting short-term exercise, but can be improved for longer-term efficacy. traditional exercise interventions are generally not individually tailored, and therefore cannot incorporate behavioral theory to re-engage participants when lapses in self-regulation occur. ehealth technologies can enhance traditional theory-based exercise interventions. the study team hypothesizes that an ehealth delivered intervention can effectively facilitate the development and maintenance of self-regulatory skills that are critical to sustaining long-term behavior change.

Eligibility criteria:
inclusion criteria: * histologically confirmed prostate cancer. * currently (in last 2-years) receiving care for prostate cancer at wfbmc. * currently owns a smartphone or a tablet computer (ios and major brand android devices not including ereaders). * english-speaking. exclusion criteria: * unable to provide informed consent (e.g., delirium). * unable to ambulate safely (fall risk).

Keywords: prostate cancer ehealth movement
oral ketones and exercise among patients with long-chain fatty acid oxidation disorders

Conditions: Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency; Carnitine Palmitoyltransferase Deficiency 2; Very Long Chain Acyl Coa Dehydrogenase Deficiency; Trifunctional Protein Deficiency

Summary: the purpose of the study is to determine if an oral ketone beverage is safe and well-tolerated during moderate intensity exercise in participants with long-chain fatty acid oxidation disorders and if it will raise blood ketones to levels similar to that reported among normal healthy subjects.

purpose: subjects with long-chain fatty acid oxidation disorders (lc-faod) do not make ketones during fasting or with exercise. ketones are an important alternative energy substrate during moderate exercise, sparing the oxidation of glucose and providing a source of atp to the central nervous system and exercising muscle. fatty acid oxidation in the liver is required to make ketones. subjects with a lc-faod cannot generate ketones because of their block in fatty acid oxidation during exercise. providing ketones in an oral ketone beverage may increase blood ketones with exercise to levels normally observed in humans. aim: to determine the safety and tolerability of an oral ketone beverage during moderate intensity exercise among subjects with a lc-faod compared to an isocaloric maltodextrin beverage, and to determine blood ketone concentrations. hypothesis: oral consumption of a ketone beverage before moderate intensity exercise will be safe and well-tolerated, and will raise blood ketones among subjects with a lc-faod to concentrations similar to that reported in the literature among normal healthy subjects.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of vlcad, lchad/tfp or cpt2 deficiency * speak english * willing to complete 2 moderate intensity exercise treadmills exclusion criteria: * subjects actively participating in another research study that prohibits their participation * pregnant females * subjects with diabetes or taking medications to treat diabetes
robotic-assisted versus conventional knee endoprosthetic techniques

Conditions: Knee Arthroplasty, Total; Robotic-assisted; Osteoarthritis of the Knee

Summary: rationale for conducting the study: the study aims to systematically evaluate the clinical and economic impacts of robotic-assisted total knee replacement (rtkr) compared to conventional total knee replacement (tkr). it focuses on the potential benefits of rtkr, including improved precision in surgery, potentially leading to better patient outcomes and reduced healthcare costs. our primary endpoint is the forgotten joint score (fjs), aimed at measuring patients awareness of their knee joint in everyday life, indicating the success of the knee replacement surgery in restoring natural joint function. secondary endpoints include patient-reported outcome measures (proms), patient activity levels, the accuracy of implant positioning on x-ray, and the incidence of adverse events. study design: multicentre,, preference-tolerant, randomized, controlled, superiority trial with two treatment arms that compares the outcomes of rtkr with traditional tkr techniques. study population: adult patients aged 18 years and older who are eligible for tkr as per local guidelines and who have given informed consent to participate in the study. number of patients: 400 inclusion criteria: patients must be adults aged 18 years and older, eligible for tkr according to local guidelines, and willing to participate in the study. exclusion criteria: patients with extreme malalignment requiring special implants or techniques, patients unfit for surgery due to medical reasons, and those deemed unsuitable to participate in the study for other reasons. primary outcome variables: the forgotten joint score (fjs) at 2 years after surgery


Eligibility criteria:
inclusion criteria: * adults aged 18 years and older. * eligible for tkr according to local guidelines and routines. * willingness to participate in the study. exclusion criteria: * patients with extreme malalignment necessitating special implants or techniques. * patients unfit for surgery due to other medical reasons. * patients who, for other reason such as alcohol or substance abuse, is deemed unsuitable to participate in the study. * patients who, for other reasons can't fulfill the required patient recorded outcome measures

Keywords: knee arthroplasty robotic assisted osteoartritis
brain-induced neurotrophic factor levels in patients undergoing coronary artery bypass surgery

Conditions: Cognitive Dysfunction

Summary: in patients undergoing coronary artery bypass surgery, the relationship between neurocognitive changes seen in the early period and brain-induced neurotrophic factor serum levels will be investigated.

although postoperative cognitive dysfunction (pokd) is the most common neurological complication in patients undergoing coronary artery bypass grafting (cabg) surgery, its pathophysiology is still not fully understood. however, the quality of this dysfunction has not been properly measured. in addition to clinical tests, biomarkers are often used to detect the presence of pokd. in this study, it was aimed to evaluate the relationship between intraoperative and postoperative brain-derived neurotrophic factor serum levels and pokd in patients undergoing cabg surgery. this prospective observational study is planned to include 30 adult patients aged 40-90 years. patients with stroke history, neurodegenerative disease, seizure history, alcohol use, general anxiety, hearing deficit, unilateral carotid artery stenosis greater than 70%, and carotid artery bilateral stenosis greater than 50% will be excluded from the study. this study aimed to determine perioperative changes in serum brain-derived neurotrophic factor levels in patients undergoing cabg surgery.

Eligibility criteria:
inclusion criteria: * at least primary school graduates, * not using drugs that may affect cognitive functions, * no alcohol substance use, * without psychiatric and neurological diseases exclusion criteria: * uneducated patients, * drug users who may affect cognitive functions (antipsychotic, antidepressant), * have alcohol and substance use disorders, * those with a history of central nervous system disease that may cause cognitive dysfunction (such as stroke, neurodegenerative disease, seizure, general anxiety), * hearing deficit, * patients with unilateral carotid artery stenosis greater than 70% and bilateral stenosis greater than 50% carotid artery
evaluation of a gatekeeper training for pharmacists

Conditions: Suicide

Summary: this study aims to investigate to what extent a gatekeeper training (e-learning) for pharmacists and pta is effective in changing the attitudes, knowledge, and self-efficacy. moreover, it aims to examine how they evaluate the training and whether they were able to apply the learned skills in practice.


Eligibility criteria:
inclusion criteria: * ≥ 18 years old * have access to internet * speak dutch * working as a (public) pharmacist or pharmaceutical technical assistant (fta) exclusion criteria: * hospital pharmacists or industrial pharmacists are not included in this study and thus constitute an exclusion criterion.