Kornimate/medical-research-clean huggingface dataset:
health and quality of life of itmo university's students, faculty and staff

Conditions: Quality of Life

Summary: this study assess various indicators of physical and mental health, quality of life, well-being and satisfaction among students, faculty and staff of itmo university. participants are invited to join the study via informational web-site. several quality of life indicators are obtained via surveys and some blood samples are taken to assess health condition.

students, faculty and staff from itmo university are invited to participate in health examination on the campus. surveys, such as eq-5d-5l, k10+ohq29, psqi and others, assess different aspects of quality of life related to health. also participants are asked to undergo several measurements by the interviewer (waist, hips, height, weight and others). moreover blood samples are taken from the participants and lipidogram, cholesterol and glycohemoglobin are checked.

Eligibility criteria:
inclusion criteria: * student, faculty or staff from itmo university * participants, who signed informed consent and consent for data gathering * participants, who signed consent to enroll in following surveys and health check-ups exclusion criteria: * participants younger than 16 years old * participants with acute conditions distorting quality of life assessment * participants, who did not sign informed consent and consent for data gathering - participants, who did not sign consent to enroll in following surveys and health check-ups

Keywords: students faculty academia university
clinical impact of intravascular ultrasound-based artificial intelligence technologies (innovate-pci)

Conditions: Coronary Artery Disease

Summary: this study is a prospective, multicenter study in the real practice to validate the diagnostic performances and clinical impact of coronary angiography \& intravascular ultrasound (ivus)-based models developed by machine learning (ml).

the aim of the study is to evaluate the performances and prognostic impact of coronary angiography \& ivus-based algorithms for decision making and stent optimization in a multicenter, prospective cohort. between january 2020 and june 2025, a total of 3,000 patients who performed coronary angiography (± ffr) and have at least one coronary stenosis requiring pci (as culprit) will be enrolled from 15 centers in south korea. in addition, the deferred lesions with visual estimated diameter stenosis of \>30% will be evaluated as non-culprits. brief study design is as depicted in the following figure. supervised ml algorithms include: 1) angiography- and ivus-based algorithms for predicting ffr, 2) ivus-based algorithm for plaque characterization, 3) ivus-based algorithm for predicting stent expansion, and 4) post-stenting ivus-based algorithm for predicting stent failure. in the prospective cohort, the performance of each model will be assessed. this registry trial composed of the treated (culprit) and the deferred (nonculprit) coronary lesions has two primary objectives as follow; 1) primary objectives in treated (culprit) lesions is to see the impact of the integrated ml model on the development of culprit-related 2-year target vessel failure (tvf). 2) primary objectives in deferred (nonculprit) lesions is to see the impact of the integrated ml model on the development of nonculprit-related 2-year tvf.

Eligibility criteria:
inclusion criteria: * age 19 years or older * symptomatic angina patients with objective myocardial ischemia * patients with at least one major epicardial coronary artery that requires stent implantation * subject who signs with informed consent form patient exclusion criteria: * st-segment elevation mi at admission * patients who underwent coronary artery bypass surgery or heart transplantation * left ventricular ejection fraction \<30% * cardiogenic shock * patients whose life expectancy \<2 years * woman who are breastfeeding, pregnant or planning to become pregnant during study * patients in whom anti-platelets or heparin is contraindicated lesion exclusion criteria: * left main culprit lesion (angiographic diameter stenosis \>50%) * thrombus-containing lesion * in-stent restenosis * side branch lesion * chronic total occlusion * small vessel with reference diameter \<2.5mm * coronary spasm despite administration of nitrate * inability for imaging catheter to pass through tight stenosis, calcification, angulations * poor image quality * angiographically visible collateral vessels

Keywords: percutaneous coronary intervention artificial intelligence machine learning intravascular ultrasound coronary angiography
canadian study of prediction of risk and evolution to dialysis, death and interim cardiovascular events over time

Conditions: Chronic Kidney Disease

Summary: this study will follow 2500 prevalent chronic kidney disease (ckd) patients with glomerular filtration rate (gfr) from 15-45 ml/min for 30 months with serial measurements every 6 months and subsequent annual chart review up to 60 months. this observational study will analyze the demographics, clinical status, medications and blood and urine samples of these patients and study the conventional biochemical, hormonal and metabolic parameters assessing which underlying biomarkers reflect the processes involved with disease progression.


Eligibility criteria:
inclusion criteria: * patients currently seen by a nephrologist, or referred for evaluation of ckd * gfr between 15-45 ml/min * adults 19 years (depending on age of consent in province) or older * at pediatric sites study participants will be eligible to participate at age 15 or older exclusion criteria: * organ transplant recipient * life expectancy less than 12 months * acute vasculitis * bioimpedance sub-study exclusion criteria: * amputation (readings are inaccurate) * any battery operated or electronic implanted device (such as pacemaker or implanted defibrillator - potential electrical hazard) * pregnant women

Keywords: chronic kidney disease renal insufficiency biomarkers observational
body awareness and spinal stability in scoliosis

Conditions: Scoliosis Idiopathic

Summary: thirty volunteer patients diagnosed with scoliosis by a specialist physician at gazi university hospital orthopedics and traumatology department and subsequently referred to gazi university physiotherapy and rehabilitation department for exercise training will be included in the study. the lumbar pressure measurement test with stabilizer and rotation stability tests will be utilized to evaluate the spinal stability of the patients. body awareness will be assessed using the body awareness survey, comprising 18 questions. all assessments will be conducted at the orthopedic rehabilitation clinic within the relevant department. the results obtained from this study will elucidate the relationship between body awareness and spinal stability in individuals with scoliosis.

the data obtained from the study will be analyzed using the statistical package for the social sciences (spss) software (ibm corp., armonk, ny, usa). results will be presented as mean ± standard deviation (x ± sd), percentage (%), or median with interquartile range (iqr), depending on their distribution normality. data conforming to a normal distribution will be compared using the independent samples student's t-test, while those not conforming will be analyzed using the mann-whitney u test. the relationship between variables will be assessed using the spearman correlation test. a significance level of p \< 0.05 will be utilized to determine statistical significance.

Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic scoliosis by an orthopedist * the cobb angle measured on the standard scoliosis radiograph should fall within the range of 10°-45°. exclusion criteria: * presence of any orthopedic or neurological disease affecting trunk and extremity mobility, excluding scoliosis. * history of previous spine or orthopedic surgery.

Keywords: body awareness spinal stability
sirolimus in graves' orbitopathy

Conditions: Graves Ophthalmopathy

Summary: graves' orbitopathy (go) is a disabling and disfiguring condition associated with graves' disease, due to autoimmunity against antigens expressed by the thyroid and orbital tissues, and resulting in orbital fibroblast proliferation and release of glycosaminoglycans. the current treatments available, especially glucocorticoids, are not effective in all patients. two cases of patients with go treated with sirolimus have been reported with an excellent response to the drug. the rationale for the use of sirolimus lies in its mechanisms of action. sirolimus is able to inhibit t-cell activation as well as fibroblast proliferation. in addition, acts indirectly on the insulin-like growth factor-1 (igf-1) pathway, and recent clinical trials have shown that a monoclonal antibody against the igf-1 receptor (teprotumumab) is effective in patients with go. thus, sirolimus could be used in go as monotherapy in patients with go. the aim of the present drug vs standard treatment, observational study is to evaluate the efficacy of sirolimus as a second-line treatment in patients with moderately severe, active go.

study design: observational thirty consecutive patients with moderate-to-severe and active go treated with sirolimus (15 patients) or methylprednisolone (15 patients) observance 18 consecutive months will be compared. study timeline baseline visit - (time 0) treatment period (week 1-week 12): daily administration of the trial agent (sirolimus) or weekly administration of the standard treatment (methylprednisolone) outcome visit (week 24)

Eligibility criteria:
inclusion criteria: 1. patients willing and capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form 2. a moderate-to-severe go, defined as the presence of at least one of the following criteria: an exophthalmos ≥2 mm compared with normal values for sex and race; presence of inconstant to constant diplopia; a lid retraction ≥2 mm 3. active go: cas (4) ≥2 out of 7 points in the most affected eye 4. previous go treatment with glucocorticoids and/or orbital radiotherapy and/or orbital decompressive surgery, performed more than 24 weeks before the current treatment 5. male and female patients of age: 18-75 years exclusion criteria: 1. optic neuropathy 2. treatment with glucocorticoids or other immunosuppressive medications, and/or selenium, and/or orbital radiotherapy and/or orbital decompressive surgery in the 24 weeks preceding the current treatment 3. mental illness that prevents patients from comprehensive, written informed consent
optimal embryonic stage for transfer in poor responders

Conditions: Poor Response to Ovulation Induction; Infertility, Female

Summary: a prospective cohort study including couples with poor responder females who undergoing icsi

purpose: to determine the optimal embryonic stage for transfer in poor responders. method: patients were divided into day 3 transfer group and day 5 transfer group. all cases had the same stimulation protocol and planning to do fresh embryo transfer. assessments will be at day 1, day 3 and day 5/6 according to gardner's criteria 1999. embryological and clinical data were recorded and then analyzed using spss (version 23) statistical software.

Eligibility criteria:
inclusion criteria: * poor responders females with amh≤ 1.2ng and have ≤ 5 mature oocytes * couples whose planning to do fresh transfer * male partners have normal semen parameters according to who 2010. exclusion criteria: * sperm or oocyte donation * gestational carriers

Keywords: poor responders embryo transfer cancellation rate implantation rate live birth rate
the vetseq study: a pilot study of genome sequencing in veteran care

Conditions: Rare Diseases; Genetic Disease

Summary: the vetseq study is a pilot intervention study exploring the feasibility of integrating genome sequencing into clinical care at the va boston healthcare system.

the vetseq study is a pilot intervention study exploring the feasibility of integrating genome sequencing into clinical care at the va boston healthcare system. healthcare providers may refer any patients who they think might benefit from diagnostic whole genome or exome sequencing. providers will briefly discuss genome sequencing and the pilot study with potentially eligible patients. if a patient is interested, the provider will refer him/her to the study by contacting the study staff and providing the reason (clinical question) why the provider thinks genome sequencing might be beneficial for the patient. the study staff will meet with the patient to conduct a baseline interview and survey, obtain informed consent for sequencing, and obtain a blood specimen for sequencing. a clinical laboratory will perform exome or whole-genome sequencing and issue an interpreted genome report including any variant possibly explaining the patient's condition, in addition to secondary monogenic, carrier, and pharmacogenomic results. this report will be sent to the referring provider, who will document the results and associated decision-making in the medical record. approximately 3 months later, study staff will conduct a follow-up interview and survey with the participating patient.

Eligibility criteria:
inclusion criteria: * patient referred by provider to study for genome sequencing * life expectancy of at least 12 months in the judgment of the referring provider exclusion criteria: * life expectancy of \<12 months * inability to give informed consent
the sdmeai study: a multi-center epidemiological study

Conditions: Eye Involvement of Systemic Diseaes; Adverse Drug Effect on Eye; Artificial Intelligence

Summary: a variety of diseases in the department of rheumatology, immunology, nephrology, and gastroenterology can cause eye lesions, and medications can also bring various adverse reactions, which can seriously reduce the quality of patients' daily life, bring additional economic burdens, and even threaten the lives of patients. this study aims to recruit patients from the aboved-mentioned departments and conduct a cross-sectional and cohort study. on one hand, we plan to compare the epidemiological characteristics of ocular lesions of systemic diseases and eye adverse drug effects in patients with rheumatology, immunology, nephrology and gastroenterology, and summarized some epidemiological indices such as prevalence, high-risk factors, etc. on the other hand, we plan to develop an artificial intelligence model after collecting certain case data. by selecting risk factors related to the occurrence of ocular lesions, we aim to train models that can predict the ocular manifestations of systemic diseases and medications.


Eligibility criteria:
inclusion criteria: * age 6-80 years old, gender is not limited * patients who have been diagnosed with systemic diseases; * patients who have ever or never used any ocular toxic drugs such as corticosteroids, chloroquine, etc.; * no history of glaucoma, cataract, scleritis, uveitis, ocular trauma, etc. before enrollment; * willing to complete follow-ups for at least 2 years. exclusion criteria: * mainly use local therapies (intraocular, intra-articular and other non-systemic drug routes); * history of intraocular surgery (such as lens implantation, vitrectomy, retinal photocoagulation); * history of glaucoma, cataract, center serous retinopathy, etc.; * history of various diseases (such as scleritis, uveitis, eye trauma, etc.) that may cause opacity of the eye under the posterior capsule; * any other diseases or conditions that affect the observation, such as diabetes, low calcium convulsions, long-term exposure to radiation before enrollment; * subjects with endogenous corticosteroids, or psychiatric diseases.
effects of bromelain and boswellia serrata casperome with centella asiatica and vitamins on edema, paresthesia and postoperative pain after quadrantectomy with or without sentinel lymph node biopsy.

Conditions: Breast Cancer Female; Pain, Postoperative

Summary: aim: to investigate the effects of dietary supplements on postoperative edema and pain in patients undergoing quadrantectomy for breast cancer. methods: 120 patients will be randomized into 3 groups: a, treated with bromelain/boswellia serrata casperome and centella asiatica with vitamins for 30 days; b, treated with bromelain/bosswellia serrata and placebo for 30 days; c, treated with 2 placebos. inclusion criteria: adult (\>18 years) patients with breast cancer undergoing quadrantectomy with or without sentinel lymph node biopsy. exclusion criteria: diabetic neuropathy, previous breast/chest surgeries, allergies to studied drugs, severe kidney failure, alcohol and toxics addiction, axillary lymphadenectomy. patients will be studied through ultrasound examination for edema and collections, vas and dn4 for pain, during 30 postoperative days. patients will also be studied through psychological and physiatric evaluations. wilcoxon, t student, chi-squared tests will be used to evaluate the outcomes. stata 14 (statacorp lp, college station, tex, usa) will be used for the analysis. p\<0.05 will be statistically significant.


Eligibility criteria:
inclusion criteria: * adult patients (\>18 years) with breast cancer undergoing quadrantectomy with or without sentinel lymph node biopsy exclusion criteria: * diabetical neuropathy * previous breast/chest surgery * allergies to studied drugs * severe kidney failure * alcohol and toxics addiction * axillary lymphadenectomy

Keywords: dietary supplements breast cancer postoperative pain postoperative edema postoperative collections
insulin in total parenteral nutrition

Conditions: Diabetes Mellitus

Summary: analyze the level of metabolic control achieved with a routine of regular insulin in the parenteral nutrition (pn) reservoir in addition to subcutaneous glargine insulin, versus only regular insulin in the pn reservoir.

a pattern of basal insulin (using subcutaneous insulin glargine and regulating the stock as prandial), plus regular subcutaneous insulin as rescue, applied to total parenteral nutrition (tpn) should be as effective (glycemic control, variability) and safe (hypoglycemia) as the usual (regular insulin inside the tpn reservoir and subcutaneous insulin as rescue) in patients with type 2 diabetes critics.

Eligibility criteria:
inclusion criteria: * adults (\>18 years) * previously diagnosed with diabetes mellitus. * hospitalized but without intensive cares. * have indication of total parenteral nutritional support (tpn, meaning the covering over 70% of the estimated daily requirements intravenously) for a minimum of 5 days. * signature of informed consent. exclusion criteria: * diabetes mellitus type 1, diabetes secondary to total pancreatectomy. * patients with intensive cares. * patients who have been prescribed tpn in intensive cares unity more than 48 hours before admission to hospitalization. * intradialytic parenteral nutrition. * patients under 18 or pregnant women. * patients with renal insufficiency stage 3 b (glomerular filtration rate \< 45 ml / min).

Keywords: total parenteral nutrition glargine insulin insulin
evaluation of the stress levels of children and their parents

Conditions: Stress Biomarkers; Anxiety

Summary: the stress levels of the participating child and their parents were evaluated using saliva to measure the stress biomarkers.

all of the dental treatments of the enrolled children were performed under general anesthesia. the stress biomarkers, such as alpha-amylase and cortisol levels, were measured from the participating child's saliva samples at pre-operative and post-operative. additionally, the stress levels of the mothers were evaluated by questionnaires at the beginning of the study.

Eligibility criteria:
inclusion criteria: the children * who did not allow their dental treatments to be completed using behavioral guidance techniques in the clinical environment. * who had no physical or psychosocial diseases were recruited exclusion criteria: the children * who were unable to give a saliva sample due to increased anxiety or inadequate saliva.

Keywords: alpha-amylase cortisol dental anxiety general anesthesia dental treatments
uterine flora during elective and urgent cesarean sections

Conditions: Endometritis

Summary: hypothesis: the bacterial flora of the uterus during elective cesarean sections differs from the uterine flora during non-elective cesarean sections. we want to study whether the uterine flora can predict post-cesarean febrile morbidity and endometritis.

objective: to evaluate the uterine flora at the time of elective and non-elective cesarean sections and to study the relationship to the development of postpartum fever and/or endometritis. methods: eight-hundred women who will be delivered by cesarean section will be enrolled in this study. cultures will be obtained during the surgery from the open uterine cavity after removal of the placenta. data regarding postpartum morbidity would be collected.

Eligibility criteria:
inclusion criteria: * cesarean delivery exclusion criteria: * vaginal delivery
complications and recurrences after mohs micrographic surgery and slow mohs

Conditions: Skin Cancer; Complication; Complication of Surgical Procedure; Complication,Postoperative; Recurrence; Recurrent Disease; Cutaneous Squamous Cell Carcinoma; Basal Cell Carcinoma; Lentigo Maligna; Lentigo Maligna Melanoma

Summary: mohs micro-graphic surgery (mohs) is a tissue-sparing, surgical treatment for different types of skin cancer (e.g. basal cell carcinoma, squamous cell carcinoma, lentigo maligna (melanoma). it is a procedure performed with frozen sections. slow mohs, a variant of micro-graphic surgery, is performed by formalin fixation and paraffin-embedded sections. both in mohs and slow mohs tumor margins are assessed to achieve complete removal. this study aims to investigate the clinical presentation and outcomes (i.e. complications and recurrence rates) in patients treated with mohs or slow mohs in the dermatology department of the maastricht university medical center+ in maastricht, the netherlands.


Eligibility criteria:
inclusion criteria: * patients with a cutaneous lesion with an indication for mohs micrographic surgery or slow mohs * patients who received a treatment with either mohs or slow mohs between 1 july 2017 and 1 july 2023 at the dermatology department of the maastricht university medical center+. exclusion criteria: * none.

Keywords: clinical presentation outcomes mohs micrographic surgery slow mohs micrographic surgery