Kornimate/medical-research-clean huggingface dataset:
predicting the efficacy of neoadjuvant therapy in patients with locally advanced rectal cancer using an ai platform based on multi-parametric mri

Conditions: Rectal Cancer

Summary: establish a deep learning model based on multi-parameter magnetic resonance imaging to predict the efficacy of neoadjuvant therapy for locally advanced rectal cancer.this study intends to combine dce with conventional mri images for dl, establish a multi-parameter mri model for predicting the efficacy of crt, and compare it with the dl and non-artificial quantitative mri diagnostic model constructed by conventional mri to evaluate the role of dl in mri predicting crt. and this study also tries to build a dl platform to assess the efficacy of larc neoadjuvant radiotherapy and chemotherapy, accurately assess patients' complete respose (pcr) after crt, and provide an important basis for guiding clinical decision-making.


Eligibility criteria:
inclusion criteria: * clinical suspicion or colonoscopic pathology of rectal cancer * age over 18 years * informed consent and signed informed consent form exclusion criteria: * poor magnetic resonance image quality, such as severe artifacts * previous treatment for rectal cancer * history or combination of other malignant tumours * not locally advanced rectal cancer (larc) * not received neoadjuvant therapy or not completed neoadjuvant therapy * no surgery * time interval between mri and surgery was more than 2 weeks * patients were lost to follow-up and voluntarily withdrew from the study due to adverse reactions or other reasons
superb trial: surgical versus percutaneous bypass

Conditions: Cardiovascular Diseases

Summary: in this multicentre randomized clinical trial, the heparin-bonded endoluminal bypass will be compared to the surgical venous femoro-popliteal bypass, based on the non-inferiority principle for the patency. besides equal patency, an improved quality of life is expected. recruitment will take the first two years and patients will be followed during five years. patients with an indication for surgical bypass, classified category 3-6 with a \>50% stenosis or occlusion of the sfa over \>/=10 cm in length will be included. at least one crural artery should be patent without significant lesions.


Eligibility criteria:
inclusion criteria: * age over 18 years * informed consent * novo stenosis, restenosis \>50% or occlusion of the native sfa, all \> 10cm in length * patent popliteal artery at the upper margin of the patella to the trifurcation * diameter native sfa and popliteal artery are 5.0-7.5 mm * indication for surgical bypass * distal run-off at least one crural artery without significant stenosis * ankle-brachial index (abi) at rest \< 0.8 in the study limb prior to procedure exclusion criteria: * patient unsuitable for administration of contrast agent * pregnancy * dementia or altered mental status that would prohibit giving conscious informed consent * need for adjunctive major surgical or vascular procedures within one month * untreated flow-limiting aortoiliac occlusive disease * perioperative unsuccessful ipsilateral percutaneous vascular procedure to treat inflow disease just prior to enrollment * femoral or popliteal aneurysm of target vessel * non-arthrotic disease resulting in occlusion (e.g. embolism, buerger's disease, vasculitis) * severe medical comorbidities (untreated cad/chf, severe copd, metastatic malignancies, dementia etc.) or other medical condition that would preclude compliance with study protocol * major distal amputation (above the transmetatarsal) in the study limb * any previously known coagulation disorder, including hypercoagulability * contraindication to anticoagulation or antiplatelet therapy * known allergies to stent/stent-graft components * history of prior life-threatening reaction to contrast agent * patients with known hypersensitivity to heparin, including those patients who have had a previous incidence of heparin-induced thrombocytopenia (hit) type ii * planned surgical procedure or major amputation to occur after enrollment of the patient

Keywords: endoluminal surgical bypass patency quality of life multicentre rct superficial femoral artery vascular patency
case studies: promoting strategy use in functional activities

Conditions: Cognitive Impairment; Executive Dysfunction; Acquired Brain Injury

Summary: the purpose of the study is to provide evidence of feasibility, acceptability, patient satisfaction, and patient perceived benefit of the multicontext (mc) approach. the project consists of eight case studies of persons with acquired brain injury undergoing acute inpatient rehabilitation who have difficulties in completing multiple step activities due to deficits in executive function and/or visual perception. the mc approach provides a structured occupational therapy framework that provides guidelines for enhancing strategy use and self monitoring skills for person's with acquired brain injury.


Eligibility criteria:
inclusion criteria: * age between 18 and 80 years * english-speaking * confirmed diagnosis of acquired brain injury (abi) based on radiological assessment * able to comprehend multistep directions and participate in conversation as assessed by the functional independence measure (fim; required score of 4 or above on comprehension and expression items) * impaired performance (\<2 sd below demographically-corrected normative data) on at least one screening measure of executive functioning * able to attend to a cognitive task for at least 10 minutes * cognitively independent in basic self-care activities * able to read standard size newsprint * ability to demonstrate functional use of at least one hand. exclusion criteria: * global aphasia or moderate - severe comprehension deficits (as indicated by a fim comprehension score of less than 4) * global cognitive impairment or dementia as indicated by a score of 20 or less on the montreal cognitive assessment * history of treatment for substance abuse or hospitalizations for psychiatric disorder, within the past year * non-english speaking
addressing fertility information needs and distress

Conditions: Childhood Cancer; Fertility Issues

Summary: the purpose of this study is to develop and refine a behavioral intervention to address fertility-related information needs and fertility-related distress among female adult survivors of childhood cancer.

adult survivors of childhood cancer are a growing population who face a number of long-term and late effects secondary to their cancer treatment, which have the potential to profoundly impact their future health, quality of life, and achievement of life goals. this project will examine the feasibility, acceptability of a novel behavioral intervention aiming to address fertility-related information needs and fertility-related distress among adult survivors of childhood cancer. following the obesity-related behavioral intervention trials (orbit) model of intervention development, the proposed study seeks to design and refine a behavioral intervention to address unmet fertility-related information needs and fertility-related distress among female adult survivors of childhood cancer (aged 18-44). the intervention is organized into six remotely delivered sessions integrating patient activation theory and acceptance and commitment therapy (act) strategies, and evidence-based reproductive health information and help to empower empower survivors to make informed decisions that align with their personal values. intervention content will be delivered to a small sample of the target population (n=30). feasibility and acceptability, as well as examination of pre- to post-intervention patterns of change in intervention targets (primary: fertility health knowledge, fertility-related distress; secondary: psychological flexibility, patient activation, and self-efficacy), will be assessed and utilized to further refine the intervention (e.g., intervention strategies, intervention length, and delivery modality). although this project is focused on the late effect of impaired fertility, the intervention developed through this study has the potential to produce significant public health benefits: it could be applied to address other late effects in this population, which if left untreated, may lead to greater health complications in this growing population later in life.

Eligibility criteria:
inclusion criteria: * currently aged 18-44 * diagnosed with cancer at \<18 years old * female sex * uncertain fertility status exclusion criteria: * age \<18 * currently under the care of a fertility specialist * having a major/serious psychiatric concern (e.g., schizophrenia) as indicated by medical chart/medical provider * inability to provide consent.

Keywords: fertility concerns fertility distress
statewide (rhode island and neighboring states) partnerships for worksite weight management

Conditions: Overweight; Obesity

Summary: the project is designed to test the effectiveness of a multilevel worksite wellness program, based in rhode island and nearby neighboring states to impact employee weight, dietary intake and physical activity, compared to an attention placebo condition.

accomplishment of the specific aim will be determined by a two group randomized effectiveness study (treatment vs. comparison) utilizing 24 ri worksites with randomization by site. the specific impact and outcome evaluation measures (bmi, dhq-ffq, and 7-day par) will be collected at baseline, 12, and 24 months on a longitudinal cohort selected at random from the employee lists of each participating worksite. extensive process evaluation and a mediating variable framework are also included to identify the mechanisms in successful change at both the worksite and individual level, which will maximize the potential for dissemination and generalization of the intervention as well as advance theory and improve intervention practice and policy. primary outcome measure will be weight (bmi).

Eligibility criteria:
inclusion criteria: worksite * worksite located in rhode island or neighboring state * has food service on site * approximately 200 - 500 employees * low rate of employee turnover exclusion criteria: * worksites outside new england cohort participants: * permanent employee, who works 20 or more hours on site * speaks/reads some english at level to complete survey eval items * able to walk at a brisk pace

Keywords: worksite weight gain prevention (among adults) obesity (among adults) physical activity nutrition
promoting ct engagement for pancreatic cancer with app

Conditions: Pancreas Cancer

Summary: to develop a culturally tailored informational mobile application and test whether it will increase participation among black pancreatic cancer subjects in clinical trial discussions with their care team. this project aims to identify and address barriers to enrollment of black subjects in pancreatic cancer clinical trials using a culturally informed mobile health application to promote participation. the clinical trial education and communication needs of black people with pancreatic cancer will be determined. a new mhealth application for clinical trial education and communication tailored to subject needs will be developed. it was hypothesized that a culturally tailored informational mobile application will increase the participation of black subjects in clinical trial discussions with their care team among the target population. this study focuses on black pancreatic cancer subjects, who experience higher mortality rates and lower clinical trial participation than white subjects. research shows that the disparity between clinical trial participation is in part due to inequitable recruitment practices. this study will use mobile application technology (mhealth app) as an educational, communication, audit, and feedback tool to promote patient-initiated clinical trial discussions among black people with pancreatic cancer and their cancer care team.


Eligibility criteria:
inclusion criteria participants must meet the following inclusion criteria in order to participate in communication \& education interview component of the study: 1. informed consent obtained to participate in the study 2. 18 years or older 3. english speaking 4. able and willing to participate in a 1-hour interview 5. history of pancreatic cancer diagnosis 6. identify as black exclusion criteria: all participants meeting any of the following exclusion criteria will be excluded from the study: 1. inability to read and speak english 2. dementia altered mental status, or any psychiatric condition that would prohibit understanding or rendering of informed consent as determined by the study physician.

Keywords: ethnicity black application
blood tests for gastritis and gastric neoplasms

Conditions: Cancer Screening Tests

Summary: helicobacter pylori infection rate is decreasing in younger population; however, biennial gastroscopy is still recommended for all koreans aged between 40 and 75 years. this study aimed to validate blood tests for gastric cancer screening according to the infection status of h. pylori (naive, current, and past infection).

helicobacter pylori-seropositive rates are decreasing in south korea. seroprevalence was 74.3% in 1990, but it decreased to 43.9% in 2016. in koreans, most gastric cancers are related to h. pylori infection. h. pylori-negative gastric cancers were found only in 2.3% among the 1,833 korean gastric cancer patients. despite these facts, the national guideline still recommends biennial gastroscopy for all koreans aged between 40 and 75 years. therefore, 8,462,570 (63.1%) koreans underwent gastric cancer screening among the target population of 13,404,927 individuals in 2021. in h. pylori-seroprevalent populations, diagnostic criteria for naive status should be strict based on histology, endoscopy, and serum pepsinogen (pg) assay findings. naive condition should be diagnosed only when both invasive and non-invasive h. pylori tests show negative findings. furthermore, there should be no intestinal metaplasia and atrophy on serum pg assay, endoscopy, and histology findings in h. pylori-naive participants. based on those findings, h. pylori infection will be confirmed when invasive tests or urea breath test was positive. h. pylori-naive status will be diagnosed if there was no eradication history, no serologically detected atrophy (pg i ≤70 ng/ml and pg i/ii ≤3), and no intestinal metaplasia or atrophy on endoscopy and histology. this study aimed to determine the validity of blood tests for gastric cancer screening according to the h. pylori infection status. we tried to identify significant variables using gastropanel tests and traditional serum pg assays in patients with gastric neoplasms.

Eligibility criteria:
inclusion criteria: * individuals who visited for gastric cancer screening exclusion criteria: * history of gastrectomy * renal insufficiency * severe comorbidities requiring prompt management

Keywords: helicobacter pylori atrophic gastritis gastric cancer pepsinogen
breath and blood ammonia response to an oral protein challenge

Conditions: Cirrhosis

Summary: the investigators specific aim is to evaluate the changes in breath ammonia in comparison to blood ammonia and other physiologic markers after a moderate oral protein challenge in healthy subjects and subjects with liver cirrhosis.

ammonia is an important molecule relevant to numerous diseases, especially to the millions of patients with cirrhosis worldwide. venous blood ammonia via limb phlebotomy, can at best roughly estimate whole body ammonia, but says little or nothing about intestinal production, and cannot "source" ammonia to any particular organ or body compartment. unfortunately, there are no presently available better tests. therefore, despite these acknowledged limitations, venous ammonia the "bronze standard" benchmark by which new metrics are assessed. the present protocol attempts to address both concerns and build upon the investigators prior high protein experience. by using a standard moderate protein challenge, the investigators can evaluate the breath ammonia responsiveness in healthy subjects and those with cirrhosis. this protocol leverages the power of breath research to evaluate responses to oral challenges. this remains a key asset of breath research. since the protocol proposes a moderate protein challenge, the investigators can evaluate disease states with minimal or no risk. as with past high protein studies, lactulose (10gm) will still be added to provoke a hydrogen response.

Eligibility criteria:
inclusion criteria: * \<18 and \<75 yrs of age exclusion criteria: * diabetic, smoker, substance abuse

Keywords: breath gastroenterology ammonia blood protein cirrhosis encephalopathy
a study evaluating splinting and casting for distal radius fractures in the elderly

Conditions: Distal Radius Fracture

Summary: distal radial fractures are the most common fracture of the upper extremity in adults, with a higher incidence in those 65 years of age or older. in 2009, karl et al demonstrated that there are 25.42 distal radial fractures in this age group per 10,000 person-years in the us. despite the frequency of distal radius fractures, there is still debate over the best method of treatment. in contrast to younger patients, patients who are 65 years or older appear to have acceptable functional outcomes and treatment satisfaction regardless of the presence of malalignment on radiographic imaging.therefore, nonsurgical management has been shown to be a viable treatment option. the purpose of this study is to compare non-operative treatment with a removable splint versus a short arm cast for distal radial fractures in patients who are 65 years of age or older who are indicated for non-operative fracture treatment.


Eligibility criteria:
inclusion criteria: * patients greater than 65 years old with isolated distal radius fracture amenable to non-operative treatment exclusion criteria: * patients younger than 65 years old * open fractures (gustilo grade 2 or 3) * pathologic fractures * multiple fractures in the upper or lower extremities * fracture indicated for surgical repair of the distal radius for any reason * lack of health insurance * inability to provide consent to the study
prevalence of transthyretin amyloidosis in hypertrophic cardiomyopathy

Conditions: Cardiac Amyloidosis; Amyloidosis in Transthyretin (TTR); Hypertrophic Cardiomyopathy (HCM)

Summary: cardiac amyloidosis are related to the accumulation of fibrillar proteins in the extracellular leading to disruption of the cardiac tissue architecture. amyloidosis in transthyretin (ttr) are the most common hereditary amyloidosis but remain poorly studied at heart. this is serious and deadly. the prevalence of ttr amyloidosis is probably underestimated in hypertrophic cardiomyopathy (hcm) often of unknown etiology because of the lack of systematic implementation of myocardial biopsy because of their side effects.

a systematic screening of ttr mutations within the mhc would diagnose cardiac amyloidosis in ttr and improve the care of patients and their families. the detection of this disease is important because this disease is fatal and a new treatment to prevent the accumulation of ttr is now available (tafamidis). this drug has proved effective in stabilizing neurological damage. depending on the number of patient with cardiac amyloidosis in ttr detected, the prospect will begin a clinical trial to test the effectiveness of a new treatment to prevent the increase in mass of the left ventricle wall objectified resonance nuclear magnetic.

Eligibility criteria:
inclusion criteria: * patients with cardiomyopathy defined by an ultrasound thickness of the left ventricle \>= 13 mm if familial form or \>= 15 mm if sporadic form. * patients with a signed consent authorizing the specific blood test for genetic sequencing to look for abnormal ttr gene exclusion criteria: * patients with a diagnosis of cardiomyopathy already determined or related already diagnosed. * significant aortic stenosis (≤ 1 cm ²)
ultrasound guided interventions of calcific tendonitis of rotator cuff (suction)

Conditions: Rotator Cuff Calcific Tendonitis

Summary: the purpose of this study is to determine whether minimally invasive treatments like ultrasound guided needle fragmentation with and without lavage is associated with better clinical outcomes compared to the subacromial bursal corticosteroid injection treatment only.

the objectives of this study are to compare the clinical outcomes of the three treatment arms: ultrasound guided needle fragmentation with lavage, ultrasound guided needle fragmentation without lavage, and subacromial bursal corticosteroid injection treatment. the study design is a randomized control trial.

Eligibility criteria:
inclusion criteria: 1. adult men or women ages 18 to 60 years 2. shoulder pain ( including impingement pain) and reduced range of shoulder movement for greater than 6 months with no relief from non-operative means (physiotherapy, nonsteroidal anti-inflammatory medication, rest). 3. documentation of failed physiotherapy and conservative management. 4. calcific tendonitis as diagnosed on ultrasound. 5. informed consent from participant. 6. ability to speak, understand and read in the language of the clinical site. exclusion criteria: 1. previous inclusion in a study involving calcific tendonitis of the rotator cuff 2. evidence of a calcification in any of the rotator cuff tendons except the supraspinatus tendon. 3. presence of a tear of the rotator cuff. 4. the supraspinatus tendon calcification is more than 1.5 cm is its largest dimension. 5. concomitant clinical or mri diagnosis of frozen shoulder. 6. previous rotator cuff or shoulder surgery. 7. those on blood thinners. 8. those with allergies to medication used. 9. those with a skin infection at the site of needle entry. 10. immunosuppressive medication use. 11. chronic pain syndromes. 12. significant medical co-morbidities (requiring daily assistance). 13. ongoing litigation or compensation claims secondary to shoulder problems. 14. age below 18 years and above 60 years. 15. any other reasons given to exclude the patient.

Keywords: calcific tendonitis rotator cuff calcific tendonitis
in-hospital diabetes management with flash glucose monitoring (iscgm) - the indigo study, part a

Conditions: Type 1 Diabetes Mellitus; Type 2 Diabetes Mellitus; Diabetes Mellitus

Summary: the aim of the study is to investigate the applicability of a flash glucose monitoring sensor (freestyle libre, iscgm) for in-hospital glucose monitoring in patients with diabetes requiring nutritional therapy (tube feeding or parenteral feeding).

all patients who meet study criteria will be invited to participate in the study. all patients included in the study will be followed by a trained clinical diabetes specialist and a trained study nurse (study personnel) for glucose management during their hospitalization. all patients included in the study will receive a freestyle libre iscgm. the patients will be randomized to control (blinded iscgm glucose values to patient and study personnel and poc (point-of-care) plasma glucose will be used for adjusting diabetes treatment) or intervention (iscgm blood glucose values will be used to aid with glucose management during the hospitalization). the study personnel will work with the patient's care team.

Eligibility criteria:
inclusion criteria: * expected length of hospital stay of at least 48 hours * diagnosed with diabetes * literate in danish * nutritional therapy using tube feeding or parenteral nutritional therapy * admission to department of gastrointestinal surgery or department of heart-, lung-, and vascular surgery, both at aarhus university hospital, denmark. exclusion criteria: * pregnancy * patient unable to provide informed consent * patient unable to use mobile phone for reading iscgm sensor * known allergy to adhesives * anticipated mri during the hospital admission * patients using cgm prior to hospital admission

Keywords: continuous glucose monitoring hospitalization nutritional therapy