Kornimate/medical-research-clean huggingface dataset:
monotherapy anticoagulation to expedite home treatment of venous thromboembolism

Conditions: Venous Thromboembolism

Summary: prospective, multicenter observational study, of the effectiveness of a standard of care protocol implemented to enhance home treatment of vte. study population will be selected as part of usual care as eligible for home treatment. study personnel will travel to participating institutions to qualify the sites, deliver a powerpoint® lecture to introduce the protocol, meet and train site principal investigators, emergency physicians and research personnel on the implementation of the protocol as part of usual clinical care, and data collection methods for a quality assurance registry with plans to use the data collected in this registry in future publications. follow-up will be 30 days using medical records and/or telephone interview to assess for primary outcomes of bleeding or vte recurrence.


Eligibility criteria:
inclusion criteria: 1. patients must be low risk, as defined by either a or b below: a. the modified hestia criteria: * systolic blood pressure \> 100 mm hg * no thrombolysis needed * no active bleeding * sao2 \>94% while breathing room air * not already anticoagulated * no more than two doses of iv narcotics in the emergency department * other medical or social reasons to admit * creatinine clearance \>30ml/min * not pregnant, severe liver disease or heparin induced thrombocytopenia or b. the physician opinion that a patients' overall social and medical situation is favorable for home treatment and the patient has a zero score on the simplified pulmonary embolism severity index (spesi). all of the following must true: * age \< 81 years * no history of cancer * no history of heart failure or chronic lung disease * pulse \< 110 beats/min * sbp \> 99 mm hg * o2 sat \>89%% we have chosen either criteria because both have been found equal in terms of safety for outpatient treatment of pe.6,22 hestia includes implicit questions that most emergency physicians would use as criteria for discharge (e.g., overall medical status and social situation), whereas spesi does not. for that reason, we have added the additional gestalt assessment question about physician discretion. 2. patients must be discharged in \<24 hours after triage in an ed visit with diagnosis of vte using objective criteria in the emergency department. exclusion criteria: * vte diagnosis while taking anticoagulants with evidence of compliance (e.g., physician opinion that patient is taking a eliquis®, xarelto® or pradaxa®, low molecular weight heparin injections or warfarin as prescribed for any condition) * sensitivity or contraindication to use of apixaban * troponin assay value, drawn as part of usual care and found to be positive, using local standards * high risk for hemorrhage defined by a score\>1.5 using the method of ruiz gimenez.3 (note that several criteria are already excluded by hestia): recent major bleeding, 2 points creatinine levels \>1.2 mg/dl, 1.5 points anemia, 1.5 points cancer, 1 point clinically overt pe, 1 point age \>75 years, 1 point
tongue images-based ai deep learning model for the prediction of esophageall varies in liver cirrhosis

Conditions: Esophageal and Gastric Varices

Summary: the goal of this observational study is to compare the tongue images of liver cirrhosis patients with high-risk and low-risk esophageal varies. the main question of this study is to explore whether there exists a relationship between the degree of esophageal varices and tongue bioinformatics in liver cirrhosis. it aims to answer 2 questions as below: question 1: if these is a significant difference in tongue images between patients in liver cirrhosis with high-risk and low-risk esophageal varices. question 2; if tongue bioinformatics could be used as a diagnostic method for prediction of esophageal varices in liver cirrhosis.

firstly, participants will be divided into two groups according to their degree of esophageal varices from endoscopic examination and ct report, including high-risk group and low-risk group. secondly, participants will be asked to show their tongue, including the surface and sublingual veins of tongue, and the tongue images of each participants will be collected by researchers via camera. after finishing tongue image collection, participants will receive a professional tongue diagnosis report in traditional chinese medicine and health suggestion. finally, tongue images will be analyzed by using ai deep learning model for information extraction.

Eligibility criteria:
inclusion criteria: 1. patients who were diagnosed with liver cirrhosis; 2. patients who received abdominal enhanced ct scans and upper endoscopic examination; 3. patients who signed informed consent; exclusion criteria: 1. patient who has previously received transjugular intrahepatic portosystemic shunt (tips), splenectomy, hepatectomy, balloon occlusion of retrograde veins or liver transplantation; 2. patient with liver cancer; (4) patients with hypertension, cor pulmnale, emphysema, heart failure and other severe systemic diseases;

Keywords: tongue bioinformatics, esophageal and gastric varices
effects of yoga on cognitive and immune function in colorectal cancer

Conditions: Colorectal Neoplasms

Summary: the purpose of this study is to determine if individuals with colorectal cancer enjoy yoga and to begin to assess whether yoga is effective in improving attention and immune function in individuals with colorectal cancer compared to physical activity and usual care.

the proposed study will use a prospective rct pilot design with three arms (yoga, resistance and flexibility exercise, usual care) and a total of 60 men and women who have completed therapy (\> 6 months post primary or adjuvant therapy) to accomplish the specific aims. equal numbers of men and women will be randomized into each arm of the study. participants will be tested before, immediately after, and 3-months after treatment or similar time points for the usual care group. after data has been collected, participants who were randomized to the resistance and flexibility exercise group (active control group) or to the usual care group will be provided with the opportunity to participate in the yoga intervention.

Eligibility criteria:
inclusion criteria: * a history of any stage new or recuurent colorectal cancer * great then 6 months post treatment for colorectal cancer * report not fully recovered from the effects of cancer and cancer treatment * no clinical signs or symptoms of brain metastasis * normal (or corrected to normal) hearing and vision * able to read and write english exclusion criteria: - conditions that could affect participation in yoga such as spinal disease or unstable joints
effect of n-methyl d-aspartate (nmda) receptor antagonist dextromethorphan on opiods analgesia and tolerance in pediatric intensive care unit patients

Conditions: Pain; Opioid Tolerance; Analgesia Tolerance

Summary: effect of n-methyl d-aspartate (nmda) receptor antagonist dextromethorphan on opiods analgesia and tolerance in pediatric intensive care unit patients


Eligibility criteria:
inclusion: * patients above 2 years, admitted in picu * on morphine or fentanyl infusions for more than 48 hours exclusion criteria: * patients under 2 years of age * patients with anticipated picu length of stay less than 3 days. * patients shall be excluded if morphine or fentanyl infusions not continued for the minimum duration of 72 hours after enrollment * patients develops hemodynamic instability * patients with hepatic failure * withdrawal request by parent(s)/guardian/family

Keywords: dextromethorphan morphine fentanyl opioid analgesia efficacy
"effect of high fat and high glycemic diets

Conditions: Type 2 Diabetes

Summary: the investigators will determine whether people with high muscle mitochondrial capacity produce higher amount of reactive oxygen species (ros) on consuming high fat /high glycemic diet and thus exhibit elevated cellular oxidative damage. the investigators previously found that asian indian immigrants have high mitochondrial capacity in spite of severe insulin resistance. somalians are another new immigrant population with rapidly increasing prevalence of diabetes. both of these groups traditionally consume low caloric density diets, and the investigators hypothesize that when these groups are exposed to high-calorie western diets, they exhibit increased oxidative stress, oxidative damage, and insulin resistance. the investigators will compare somalians and ne americans who are matched for age, bmi, and sex. the investigators will measure ros production in skeletal muscle following high fat/high glycemic diet vs. healthy diet. the investigators will compare the oxidative damage to proteins, dna, and lipids in these two populations following 10 days of high fat/high glycemic index diet in comparison with low fat diet. the investigators will determine if elevated levels of oxidative damage in somali immigrant populations is accompanied by high mitochondrial capacity, higher ros-emitting potential, and lower insulin sensitivity than ne. the proposed study will be performed utilizing the state-of-the-art proteomic and metabolomic methods many of which were recently developed in our laboratory. the investigators expect the results from this study to provide seminal insights into the underlying mechanism of insulin resistance and type 2 diabetes, in addition to demonstrating mechanisms by which a functional proteome is maintained in vivo.


Eligibility criteria:
inclusion criteria: * somali immigrants age 40-65, * bmi 23-34 kg/m2, * sedentary (exercise less than 2 days per week for less than 20 minutes). inclusion criteria: * for northern european descendants same as for somali immigrants plus need to match a somali immigrant for age, bmi and habitual activity. exclusion criteria: * triglycerides on screening examination of greater than 300; * pregnant or lactating women.
comparing double dose of vaginal progesterone to no treatment for prevention of preterm birth in twins and short cervix

Conditions: Premature Birth

Summary: twin pregnancies are more likely to be delivered preterm than singleton pregnancies. vaginal progesterone administration (200 mg utrogestan) to asymptomatic women with a singleton pregnancy and sonographic short cervix reduced the risk of preterm birth (ptb) and neonatal morbidity and mortality, yet not proved efficient in twins' pregnancy. the investigators' hypothesis is that a higher dose of vaginal micronized progesterone will be more effective in preventing ptd. the objectives of the study is to compare the rate of preterm birth and perinatal morbidity and mortality in a twin pregnancy with short cervical length treated with vaginal 400 mg of micronized progesterone to no treatment. the study is randomized, open label, of twin pregnancy between 16-26 weeks of gestation with cervical length under 25 mm. women will be randomly assigned to either treatment or no treatment group. progesterone treatment will be given until 36 weeks of gestation. other management will be according to standard protocol.


Eligibility criteria:
inclusion criteria: * twin gestation * certain dating (documented first trimester ultrasound, or a reliable menstrual date confirmed by an ultrasound performed before 20 weeks of gestation) * age \> 18 years * gestational age 16-26 * cervical length\<25 mm * intact membranes * informed consent exclusion criteria: * major malformation or chromosomal abnormality to at least one fetus * higher order pregnancy * mocochorional-monoamniotic twin * death of one fetus * cervical dilatation \>3 cm * chronic medical conditions that would interfere with study participation or evaluation of the treatment (e.g. seizures, psychiatric disorders, uncontrolled chronic hypertension, congestive heart failure, chronic renal failure, uncontrolled diabetes mellitus with end-organ dysfunction, active thrombophlebitis or a thromboembolic disorder, history of hormone-associated thrombophlebitis or thromboembolic disorders, active liver dysfunction or disease, known or suspected malignancy of the breast or genital organs)
postoperative pain in adolescent idiopathic scoliosis surgery

Conditions: Scoliosis; Adolescence

Summary: scoliosis is a 3-dimensional, structural deformity of the spine. idiopathic scoliosis is the most common type and it constitutes 75-80% of all scoliosis. surgical methods are the most effective way to correct the deformity in patients who cannot achieve adequate improvement with supportive therapy. adolescent idiopathic scoliosis surgeries are among the most invasive surgeries performed on children and adolescents. large surgical incision and massive tissue damage cause severe postoperative pain. in this study, we aim to compare posterior instrumentation (pe) and vertebral body tethering (vbt) surgeries performed in adolescent idiopathic scoliosis patients in terms of anesthetic management and postoperative pain.


Eligibility criteria:
inclusion criteria: * asa score 1-3 patients * adolescent idiopathic scoliosis patients * patients who accepted to be included in the study and received written parental consent exclusion criteria: * patients with vertebral anomaly due to a secondary reason * patients with a diagnosed syndrome * patients with a cobb angle below 40. * patients who undergoing reoperation
establishing automatic method of counting and classify bone marrow and peripheral blood cells

Conditions: Hematologic Diseases; Artificial Intelligence; Acute Leukemia

Summary: counting and classification of blood cells in a bone marrow smear and peripheral blood smear are essential to clinical hematology. to this date, this procedure has been carried out in a manual manner in the great majority of clinical settings. there is often inconsistency in the counting result between different operators largely due to its manual nature. there has not been an effective and standard method for blood smear preparation and automatic counting and classification. the recent advent of deep neural network for medical image processing introduced new opportunities for an effective solution of this long-standing problem. numerous results have been published on the effectiveness of convolutional neural network in clinical image recognition task.


Eligibility criteria:
inclusion criteria: * patients who have suspected or confirmed hematological diseases and receive bone * marrow or peripheral blood cell morphological examination in national taiwan university cancer center * patients who are aged more than 20 y/o exclusion criteria: •patients who are not willing to sign informed consents
impact of peer education program on headache disorders

Conditions: Headache Disorder

Summary: worldwide, headache disorders are among the most common medical conditions. many people with headache need not experience further pain if the diagnosis and treatment are correct. most patients do not have correct diagnosis and treatment. this study tested a model for treatment of people with headache disorders at primary health-care level in rural areas of haryana, india.


Eligibility criteria:
inclusion criteria: * all residents of the region kaithal (haryana) may apply for recruitment * primary headache disorders including tension type headache, migraine exclusion criteria: * planning to move the area * refused to consent
collagen crosslinking for keratoconus - a randomized controlled clinical trial

Conditions: Keratoconus

Summary: the purpose of this study is to determine whether corneal collagen crosslinking is effective in the treatment of progressive keratoconus.

keratoconus is a noninflammatory, asymmetrical, progressive corneal ectasia caused by biomechanical instability of the corneal stroma. treatment modalities are primarily glasses or contact lenses. it has been estimated that one out of five patients will progress to such an extent that a corneal transplant is necessary to regain useful vision. corneal collagen crosslinking (cxl) is a treatment modality that intends to halt progression of keratoconus. this study investigates the efficacy av cxl in stabilizing the cornea in keratoconus by means of a randomized controlled clinical trial. participants are eligible for inclusion if progressive keratoconus is confirmed and the inclusion criteria are met. follow-up after inclusion is at 1 week (treatment group), 1, 3, 6 and 12 months. pre- and post-inclusion examinations include measurement of uncorrected distance visual acuity (ucdva), best spectacle corrected distance visual acuity (bscdva), scheimpflug-topography and slitlamp examination.

Eligibility criteria:
inclusion criteria: * keratoconus diagnosis determined clinically and topographically (kisa%- index) * significant progression is defined as change (increase) of kmax by at least 1d from baseline at 6 months and/or change (increase) of sim-k-ast by at least 1d from baseline at 6 months. kmax is defined as the steepest radius of curvature (either the maximum simulated k-reading or the maximum k-reading in the 3-mm zone or the 5-mm zone) of the anterior corneal surface that progressed the most during 6 months observation * ability to stop contact lens (rigid and soft) wear at least two weeks prior to next exam * signed written informed consent exclusion criteria: * age \< 18 years * pregnancy * breast feeding * history of corneal surgery * history of ocular herpes simplex infection * minimal corneal thickness \< 300 micrometers * recurrent corneal erosions * other corneal (e g endothelial) or conjunktival diseases * neurodermatitis * severe forms av atopic disease * collagenoses, autoimmune or other systemic disease * systemic treatment with high doses of steroids * severe scarring och striae of the cornea relative exclusion criteria: * kmax \> 58d * minimal corneal thickness \< 400 micrometers (a modified cxl-treatment will be used swelling the cornea before uv-illumination treatment).

Keywords: collagen crosslinking keratoconus
physical activity in patients with rheumatoid arthritis treated with adalimumab in routine clinical practice

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study was to evaluate physical activity and its changes in participants with rheumatoid arthritis (ra) who were treated with adalimumab therapy in clinical practice.

this post-marketing observational study was conducted in a multi-country, multi-center and single-arm format. data were collected prospectively. adult participants with diagnosis of ra who were assigned for treatment with adalimumab (humira®) were eligible for participation. during this period four follow-up visits were planned for observation of the participant and documentation of data. ideally, these visits should have been performed approximately 3 (v1), 6 (v2), 9 (v3) and 12 (v4) months after the baseline visit (v0).

Eligibility criteria:
inclusion criteria: * had rheumatoid arthritis (ra) and is eligible to start and/or continue adalimumab therapy according to the local product label and prescription guidelines * had been started on adalimumab therapy no more than one (1) month prior to the study enrolment * had negative result of tuberculosis (tb) screening test or was receiving tb prophylaxis as per local guidelines * had provided written authorization to the investigator to use and/or disclose personal and/or health data, or informed consent if requested by the local regulations exclusion criteria: * was unable to walk either due to ra or a comorbid condition * was unable to perform basic self-care activities * had contraindications for treatment with adalimumab

Keywords: post-marketing observational study (pmos) protocol rheumatoid arthritis physical activity adalimumab humira®
assessment of vardenafil in patients with erectile dysfunction in asia

Conditions: Erectile Dysfunction

Summary: to demonstrate the efficacy, safety and tolerability of 10 mg oral vardenafil (bay 38-9456) compared to placebo for a period of 12 weeks in men with erectile dysfunction (ed)


Eligibility criteria:
inclusion criteria: * age: 20 years and older- males with erectile dysfunction * stable heterosexual relationship exclusion criteria: * primary hypoactive sexual desire * history of myocardial infarction, stroke or life-threatening arrhythmia within the prior 6 months- nitrate use * other exclusion criteria apply according to the summary of product characteristics

Keywords: erectile dysfunction vardenafil
intra-articular autologous bone marrow aspirate injection for knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: knee osteoarthritis (oa) is a leading cause of disability. the objectives of treatment are to reduce pain, improve function, and slow down further breakdown of the knee. recently, research on nonsurgical treatment options for knee oa has increased significantly. one potential treatment of interest is the use of stem cell injections. stem cells are one's own cells that have the ability to divide into other types of cells, and may cause regrowth of cartilage when injected into the knee. there have been few, but promising, studies that show improvements in pain and function with stem cell injections in those with knee oa. therefore, more research is needed to identify patients who might benefit from this injection. this pilot study will look at changes in pain and function for 20 patients at 1, 3, 6, and 12 months after a stem cell injection into the knee. patients will also undergo magnetic resonance imaging at 6 months and 12 months following the injection.


Eligibility criteria:
inclusion criteria: * \>=3 months of symptomatic knee oa unresponsive to at least two of the following: activity modification, physical therapy, bracing, assistive devices, acupuncture, non-steroidal anti-inflammatory medications, local steroid injections, and hyaluronic acid injections * radiographically confirmed kellgren-lawrence i-ii knee oa (mild knee oa; no bone-on-bone) * age 18-79 years exclusion criteria: * presence of loose bodies on baseline magnetic resonance imaging * clinically and radiologically confirmed anterior/posterior cruciate ligament deficiences * history of meniscal injury other than degenerative meniscal tears * previous knee surgery * presence of a degenerative meniscal tear causing mechanical symptoms such as locking, buckling, or give-way * intra-articular injection to affected knee within 6 weeks of intra-articular bma injection * mechanical axis deviation greater than 7 degrees * intolerance to acetaminophen or hydrocodone (i.e., vicodin) * use of non-steroidal anti-inflammatory drugs \<1 weeks prior to bma * injection of the joint scheduled for treatment within 3 months of bma injection * body mass index of 30 or more * history of drug abuse * current cigarette smokers * current use of systemic steroids * history of or current alcohol abuse or dependence * history of anemia, bleeding disorders, or inflammatory joint disease * active infection * active malignancy per medical or surgical history, diagnosed by primary case physician or treating specialist, undergoing treatment, has undergone treatment, or has declined treatment * inability to refrain from statin regimen from 1 month pre-injection to 1 month post-injection * pregnancy or breastfeeding at time of treatment * participating or planning to participate in a worker's compensation program at the time of treatment or follow-up period * pending or planned legal action pertaining to knee pain * non-english speaking