Kornimate/medical-research-clean huggingface dataset:
effects of triflow and deep breathing and cough exercises on respiration in patients undergoing mitral valve replacement

Conditions: Mitral Valve Failure; Surgery

Summary: the purpose of breathing exercises or the use of assistive devices is to provide deep breathing after surgery and to obtain a normal breathing pattern. the purpose of choosing the method to be applied is to obtain the best result. the results of the few studies conducted on this subject are contradictory and insufficient. in this context, the purpose of this study is to compare the effects of using only triflow and using triflow together with deep breathing and cough exercises on postoperative respiratory functions in patients who underwent simultaneous tricuspid valve surgery for mitral valve.

mitral valve disease is one of the most common causes of heart failure and death. although heart valve diseases are not as common as heart failure, coronary artery disease or hypertension in developed countries, they are important because they are common and usually require intervention. in addition, rheumatic valve diseases are still an important public health problem in developing countries, and they mostly affect young patients. since mitral valve diseases can progress without symptoms for a long time, when they are noticed, the damage to the valve may have reached a moderate or severe level. therefore, it is necessary to carefully decide whether medical or surgical treatment is appropriate. the most common complications after mitral valve replacement are bleeding due to anticoagulant use, thromboembolism and deterioration in the valve structure, and some complications can be seen after surgery. the most common complications encountered are lung complications. the visibility of lung complications usually varies between 8-79%. the aim of this study is to compare the effects of using triflow alone and using triflow with deep breathing and cough exercises on postoperative respiratory functions in patients undergoing coronary artery bypass surgery.

Eligibility criteria:
inclusion criteria: * volunteering to participate in the study literate and knowing the native language exclusion criteria: * hemodynamically unstable patients, patients who develop postoperative respiratory complications, lip or palate anomalies

Keywords: triflow respiratory functions cough exercise
a trial to assess the effect of high nitrogen intake in critically ill patients

Conditions: Critically Ill

Summary: the patients with sepsis are in high risk of malnutrition, which could contribute to infection, difficulty in weaning from ventilators. the investigators speculate whether nutrition therapy with high nitrogen could attenuate the malnutrition status and improve the outcome in these sepsis patients. in this prospective randomized controlled trial, the investigators aim to compare high nitrogen intake with conventional nitrogen supply which were recommended in guidelines.


Eligibility criteria:
inclusion criteria: * need mechanical ventilation for more than 2 days * mean blood pressure more than 60mmhg * predicted icu stay more than 7 days * tolerance of parenteral or enteral nutrition exclusion criteria: * irreversible status of primary disease * any history of malnutrition before enrollment * history of steroid cortisol administration * severe liver dysfunction (child-pugh score c) * pregnancy * refuse to enrollment * re-admission to icu and has been enrolled during former admission to icu

Keywords: mechanical ventilation
observe intestinal tract cleaness of senile constipation patients used gastrointestinal external stimulation

Conditions: Electric Stimulation

Summary: this is a prospective, randomized, double-blind controlled trial. elderly patients with constipation requiring colonoscopy were randomly divided into four groups: 1. received both gastrointestinal external stimulation and transcutaneouselectrical acupoint stimulation; 2. received gastrointestinal external stimulation singly; 3. received transcutaneouselectrical acupoint stimulation singly; 4. no stimulation was given. all groups received oral administration of polyethylene glycol for intestinal cleansing. boston bowel preparation scale (bbps) score was used to assess the quality of intestinal cleanliness , with a total score of 9, and higher scores indicating better intestinal cleanliness, and bbps≥6 was defined effective.

the early detection of intestinal lesions is extremely important, and the quality of intestine cleanliness is an important factor for the quality of colonoscopy. the elderly are at high risk of intestinal diseases. however, surveys have found that the overall quality of bowel cleanliness in elderly patients undergoing colonoscopy is poor, which affects the detection rate of colon lesions. this is a prospective, randomized, double-blind, controlled clinical trial to observe whether combined gastrointestinal surface stimulation and transcutaneous electrical acupoint stimulation can improve the quality of bowel cleansing and increase the detection rate of intestinal diseases. elderly patients with constipation requiring colonoscopy were randomly divided into four groups: 1. received both gastrointestinal external stimulation and transcutaneouselectrical acupoint stimulation; 2. received gastrointestinal external stimulation singly; 3. received transcutaneouselectrical acupoint stimulation singly; 4. no stimulation was given. all groups received oral administration of polyethylene glycol for intestinal cleansing. boston bowel preparation scale (bbps) score was used to assess the quality of intestinal cleanliness , with a total score of 9, and higher scores indicating better intestinal cleanliness, and bbps≥6 was defined effective.

Eligibility criteria:
inclusion criteria: 1. age 60-80 years old; 2. colonoscopy was planned; 3. the diagnosis of constipation was in accordance with rome ⅳ criteria. exclusion criteria: 1. acute myocardial infarction (within 6 months), severe heart failure (new york heart association class ii-v, chronic renal failure (ckd stage ii-v), or mental disorder; 2. colorectal resection; 3. drugs of aspirin, warfarin, or other anticoagulants, and coagulopathy; 4. oral administration any drugs that may affect gastrointestinal motility, such as proton pump inhibitors, non-steroidal anti-inflammatory drugs or antibiotics (within 4 weeks), probiotics (within 2 weeks); 5. the following diseases：inflammatory bowel disease, frequent diarrhea, severe gastroparesis, intestinal perforation or obstruction; 6. participating in other clinical trials.

Keywords: ntestine cleanliness senile constipation patients gastrointestinal external stimula
the absorption rate of subcutaneous infused fluid

Conditions: Aged, 75 and Over; Aged; Hypodermoclysis; Fluid Therapy; Dehydration

Summary: the purpose of the study is to examine the rate of absorption of subcutaneous infused fluid in older adults when acutely ill compared to when they are not acutely ill.

dehydration is a common condition in older adults. when oral hydration is insufficient there is a need for parenteral hydration. subcutaneous infused fluid or hypodermoclysis is a method for parenteral hydration. this method is used to treat older adults with mild to moderate dehydration or at risk of dehydration. despite that, this method is used in older adults who are acutely ill we have a very limited understanding of the absorption time and thereby when the infused fluid is available in the circulatory system. this study aims to compare the absorption time in older adults who are acutely ill with when they are not acutely ill. furthermore, this study aims to describe how fast the subcutaneous infused fluid is absorbed from the subcutaneous space and subsequently when it is available in the circulatory system where it has its effect.

Eligibility criteria:
inclusion criteria: * ability to give informed consent * hospitalized for an acute illness exclusion criteria: * severe limitation on fluids * risk of acute deterioration of illness * requiring constant care * short life expectancy

Keywords: dehydration fluid therapy hypodermoclysis geriatric sodium pertechnetate tc 99m
eosinophilic esophagitis: influence of dilation on dysphagia and inflammation

Conditions: Eosinophilic Esophagitis; Esophageal Stenosis; Esophageal Dilation; Esophageal Dilatation

Summary: a database analysis and review of histological slides (retrospective) and a patient questionnaire analysis (prospective) will be conducted in bern (switzerland) to evaluate the efficacy and safety of esophageal dilation and its effect on the underlying eosinophilic inflammation in patients with eosinophilic esophagitis. this trial is investigator driven.

eosinophilic esophagitis (ee) is a chronic, increasingly recognized disease of the esophagus, clinico-pathologically characterized by a proton-pump-inhibitor resistant, dense esophageal eosinophilia in combination with esophagus-related symptoms. patients suffer mainly from dysphagia, a feared long-term complication is the evolution of esophageal stenoses leading to food-bolus impaction that have to be removed endoscopically. anti-inflammatory therapy with systemic or topical corticosteroids have shown to be efficacious in children as well as in adults. however, relapses occur in general soon after the cessation of this medication. in addition, several studies have demonstrated that in adults with active ee dilation is an alternative safe and efficacious therapeutic option. surprisingly, the symptom-free period seems to be much longer after this procedure than after medical treatment. today, the selection of these two procedures depends more on local practices than on evidence based data, because robust data are lacking. furthermore, there are concerns regarding the risk of the dilation-procedure (possible esophageal perforations and major bleeding). furthermore, it has not yet been assessed if dilation changes the underlying eosinophilic inflammation. if not, investigations should be performed to evaluate if long-term anti-eosinophilic therapy is able to change the natural course of the disease and reduce the stricturing complications.

Eligibility criteria:
inclusion criteria for retrospective database analysis: * adult patients with - according to the database inclusion criteria - confirmed active ee, having 1. pre-dilational upper endoscopy (egd) including histology and 2. dilation and 3. post-dilational egd/histo * definitions: active ee is defined as 1. symptoms of dysphagia on almost each intake of solid food when off anti-inflammatory therapy or dietary restriction; 2. presence of an eosinophilic tissue infiltration with a peak cell density of \>24 eosinophils per hpf x 400 on histology of esophageal biopsies. * inclusion criteria for additional, prospective, comprehensive histologic and immunologic * work-up: "comparable" time frame between baseline and post-dilational biopsy sampling exclusion criteria: * therapy with anti-eosinophilic medications 12 weeks prior to pre-dilational egd and dilation respectively and between dilation and post-dilational egd/histo.

Keywords: eosinophilic esophagitis dysphagia esophageal bougienage esophageal dilation
tele nursing counseling on anxiety and patient satisfaction in same day surgery

Conditions: Ambulatory Surgical Procedures

Summary: the study was planned to be conducted as a randomized controlled experimental study to examine the effect of preoperative tele-nursing counseling on anxiety and patient satisfaction in same day surgery. the main research hypotheses are; preoperative tele-nursing counseling has no effect on anxiety in same day surgery. preoperative tele-nursing counseling has an effect on anxiety in same day surgery. preoperative tele-nursing counseling has no effect on patient satisfaction in same day surgery. preoperative tele-nursing counseling has an effect on patient satisfaction in same day surgery.

power analysis was performed using the g\*power (v3.1.7) program to determine the number of samples. the power of the study (α) was accepted as 0.05 (95% confidence level), type 2 error probability (β) was accepted as 0.20 (80% power level) and the effect size of 0.46 in the relevant literature (pehlivan, 2021) was taken into account, and the minimum required minimum in the groups was taken into account. it was found that taking the sample size as 74 would be sufficient. in the study, it was aimed to have a total of 148 participants, 74 for the control group and 74 for the experimental group. considering the possible loss, the study was completed with a total of 160 patients, 80 of which were in the control group and 80 in the experimental group. while evaluating the findings obtained in the study, spss (statistical package for the social sciences) version 25.0 (ibm corp., armonk, ny, usa) program will be used for statistical analysis.

Eligibility criteria:
inclusion criteria: * above 18 years old, * agreeing to participate in the research, * persons who will undergo day surgery in the field of general surgery, urology, orthopedic surgery, plastic surgery, neurosurgery, * gks score of 15, * not addicted to alcohol * no psychiatric problems, * not using antipsychotic, antidepressant and anxiolytic drugs * according to the asa (american society of anesthesiologists) classification, asa 1-2-3 -classification * speech and hearing impaired * it is planned to include patients who have an open phone in the study. exclusion criteria: * preoperative hospitalization * patients undergoing emergency surgery * patients who want to leave the study at any stage of the study

Keywords: ambulatory surgery anxiety patient satisfaction
blood spot self-administered test and assay

Conditions: Dysfunction; Endocrine; Effects of Chemotherapy; Premature Ovarian Failure

Summary: the current study will compare hormone levels of amh, fsh and inhibin b in blood specimens collected by venipuncture and fingerstick in a sample of pre-menopausal women ages 18-45 years with normal menstrual cycles.

recent advances in cancer diagnosis and treatment have led to greater survival rates in patients with malignancies. however, these life-saving treatments, especially alkylating agents, often lead to premature ovarian failure, infertility and related long-term health problems. it is difficult to predict whether, and the extent to which, patients will experience these problems. there are no early clinical signs of decreased fertility potential; even young women who maintain cyclic menses after therapy are at high risk of infertility, early menopause and related health problems. preliminary studies suggest that several surrogate measures of fertility potential are different in cancer survivors compared with controls. these include follicle stimulating hormone (fsh), estradiol, anti-mullerian hormone (amh) and inhibin b. large longitudinal studies are needed to validate these measures with gold standard outcomes such as pregnancy rates, pregnancy outcomes and time to menopause. the main impediment to assessing the value of these markers and generating data that is useful to cancer survivors is the need for frequent and timed blood samples. daily or frequent trips to the clinical center are not practical and reduce the compliance of even the most motivated patients. the hypothesis that will be tested by this study is that blood spot assays can be developed that provide robust, personalized data for surrogate markers of reproductive function which can be used to assess reproductive potential in women; furthermore, bloodspots collected at home are an acceptable method for reproductive hormone measurement in women with and without a history of cancer. the current study will compare hormone levels of amh, fsh and inhibin b in blood specimens collected by venipuncture and fingerstick in a sample of subjects.

Eligibility criteria:
inclusion criteria: * adult females * age between 18-45 years * premenopausal (defined as menses in the past 12 months) * postmenarchal * presence of an intact uterus and two ovaries * ability and willingness to comply with study protocol exclusion criteria: * pregnancy within the previous 3 months * lactation within the previous 3 months

Keywords: healthy premenopausal postmenarchal chemotherapy alkylating agent alkylator high dose cancer therapy low dose cancer therapy
a randomized controlled trial of best approach to care compared to diversified chiropractic adjustive technique

Conditions: Low Back Pain; Headache; Shoulder Pain

Summary: there are a variety of treatment approaches used by the chiropractic profession. some of these require forceful joint manipulation and some do not. this study is designed to compare outcomes of two such techniques that are common to chiropractic practice. the hypothesis is that there is no difference between forceful and non-forceful approaches to treatment.

the comparison will permit a one month treatment period for both techniques and a three week follow-up. patients will be assessed at baseline (intake), and at specified intervals and at three weeks following the termination of care.

Eligibility criteria:
inclusion criteria: chronic musculoskeletal pain ability to communicate in english exclusion criteria: pregnancy contraindications to manipulation pending litigation chiropractic care within the last month

Keywords: chiropractic spinal manipulation low back pain
polymyalgia rheumatica and giant cell arteritis

Conditions: Polymyalgia Rheumatica; Giant Cell Arteritis

Summary: the purpose of this study is to delineate the association of the 18f-fluorodeoxyglucose positron emission tomography/computed tomography (18f-fdg pet/ct) detected vasculitis pattern of the large vessels (pet positivity) and the clinical picture of polymyalgia rheumatica (pmr)/giant cell arteritis (gca) .

introduction: polymyalgia rheumatica (pmr) and giant cell arteritis (gca) are common inflammatory conditions. the diagnosis of pmr/gca poses many challenges since there are no specific diagnostic tests. recent literature emphasizes the ability of 18f-fluorodeoxyglucose positron emission tomography/computed tomography (18f-fdg pet/ct) to assess global disease activity and/or inflammation burden. 18f-fdg pet/ct may lead to make diagnosis at an earlier stage than conventional imaging and assess response to therapy. with respect to the management of pmr/gca, there are three significant areas of concern as follows: vasculitis process/vascular stiffness, malignancy and osteoporosis. methods and analysis: patients: all patients with the suspicion of pmr/gcr will be offered to participate in the study. the current protocol consists of 4 separate studies including: i) the association of clinical picture of pmr/gca with pet detected vasculitis ii) evaluating validity of 18f-fdg pet/ct scan for diagnosis of pmr/gca compared to temporal artery biopsy iii) incidence of new diagnosed malignancies in patients with pmr/gca, or pmr like syndrome with the aim of pet/ct scan and chest x ray/abdominal ultrasound iv) impact of disease process as well as steroid treatment on bone mineral density, body composition and vasculitis/vascular stiffness in pmr/gca patients.

Eligibility criteria:
inclusion criteria: * at least five (a-e) components of the pmr diagnostic criteria, including: * a. age ≥50 years, * b. bilateral shoulder or hip pain, * c. morning stiffness lasting \>45 min, * d. elevated erythrocyte sedimentation rate (esr), * e. elevated c-reactive protein (crp), * f. disease duration \>2weeks, should be met to suspect pmr. * for gca following criteria's must be seen: age \> 50 years, esr/crp \> 50, as well as at least two symptoms related to vasculitis (scalp tenderness, vision disturbances, headache (new or changed), jaw claudication, tenderness of the temporal arteria) if patients do not simultaneously have pmr. if the patient is suspected for pmr, one cranial symptom is enough to suspect gca. exclusion criteria: * dementia * inability to communicate in danish * infections or malignancy when prednisolone is permanently unsuitable * contraindication to imaging studies (allergy to contrast materials, reduced kidney function, pregnancy and blood sugar (bs) \>8 mmol/l after 6 hours fasting) * initiation of steroid treatment before the pet scan * inability to provide informed consent
targeted hypothermia during cardiac surgery

Conditions: Cardiac Surgery

Summary: this study designed to evaluate the safety and feasibility of the neurosave device to rapidly reduce brain temperature while maintaining the brain at a lower temperature than the body core during cardiac surgery.


Eligibility criteria:
inclusion criteria: * ≥18 years of age * undergoing coronary revascularization or valvular cardiac surgery * the study patient or the study patient's legal representative has been informed of the nature of the study, agrees to its provisions and has provided written informed consent as approved by the human research ethics committee (hrec) of the respective clinical site * the study patient agrees to comply with all study -related procedures exclusion criteria: * women known or suspected to be pregnant (as confirmed by a pregnancy test for all women of child-bearing age) * past history of cerebrovascular accident (stroke or tia) * history of clinically diagnosed active psychiatric conditions * emergency or salvage cardiac valve operations * body weight \< 50 kg * leukopaenia (wbc \< 3000 cell/ml), anaemia (hgb \< 11g/dl), thrombocytopaenia (plt \< 50,000 cell/ml) * active upper gi bleeding within 3 months (90 days) prior to procedure * renal insufficiency (creatinine \> 265 micromol/l) and/or renal replacement therapy at the time of screening * estimated life expectancy \< 12 months (365 days) * structural abnormality or disease of nose, mouth, pharynx and oesophagus (excluding gastric reflux oesophagus disease), * currently participating in an investigational drug or another device study that would potentially impact the results of this study as determined by the pi. note: trials requiring extended follow-up for products that were investigational, but have since become commercially available, are not considered investigational trials