Kornimate/medical-research-clean huggingface dataset:
development and evaluation of web-based fertility-related decision support for young female cancer patients

Conditions: Infertility, Female; Female Infertility

Summary: this study aims to develop a patient-centered, user-center, interactive web-based decision aid to support the young women with cancer in making an informed fertility-related decision and further evaluate its efficacy.

this study uses mixed-method and involves 2 stages. as following the ipdas recommendation for developing decision aids, the first sample of 25 young woman survivors with breast, hematology or ovarian cancer, and oncologist, fertility specialists or nurses will be interviewed to assess the fertility-related decision needs from and. the decision aid is then developed further process of evidence synthesis and multidisciplinary external review. after the draft being evaluated for its validity via think-aloud cognitive interview method, field testing via one-group quasi-experimental design on 90 young women with newly diagnosed breast, hematology or ovarian cancer will be applied to test its outcomes of decision quality, emotional health and fertility concerns.

Eligibility criteria:
inclusion criteria: * age between 20 to 44 * have been diagnosed with breast, hematology or ovarian cancer, and will conduct cancer treatment, such as chemotherapy, hormonal or radiation. * willing to take questionnaire via computer and tablet. * ability to answer the questionnaire with functional emotion and cognition. * ability to read newspaper. * had been consulted and advised by doctor on the ability of fertility, but have not decided to give birth to a baby. exclusion criteria: * age below 20 or above 45. * had been diagnosed with stage 4 cancer. * do not require chemotherapy, hormonal or radiation therapy. * not able to read newspaper or do not access the internet.

Keywords: infertility young female cancer patients decision aids fertility concerns
cardiac and endothelial function response to early exercise training after coronary artery bypass surgery

Conditions: Coronary Artery Bypass Grafting; Coronary Artery Disease; Cardiac Rehabilitation

Summary: background: coronary artery bypass grafting (cabg) due to coronary artery disease (cad) is one of the main surgical procedures performed in the area of cardiology. individuals undergoing cabg present sarcopenia, decreased muscle strength of the lower limbs, decreased respiratory muscle strength and dyspnea due to immobility in the bed and the inherent conditions of the disease itself. cardiorespiratory rehabilitation techniques are rarely used with measurement in hospitals and can greatly favor an early and effective reestablishment to this population in several parameters. objective: to evaluate the effect of functional electrical stimulation (fes), ventilatory muscle training (tremven), early aerobic training (aero) and isometric handgrip training (iso) on the functional capacity, endothelial function and cardiac parameters of individuals undergoing cabg. methods: in a randomized clinical trial, volunteers will be allocated into four groups: eef, tremven, aero or iso in the preoperative period of cabg. after 48 hours (postoperative midway) of the surgery, the protocol will begin until after hospital discharge. the endpoints evaluated will be: functional capacity, respiratory muscle strength, systolic and diastolic function, arterial endothelial function, inflammatory profile and plasma levels of vascular endothelial growth factor (vegf). scientific contributions: phase 1 cardiorespiratory rehabilitation with alternative interventions may provide an increase in functional capacity, strengthening of respiratory muscles, improvement in cardiac and endothelial functions, as well as increased systemic vegf levels (myocardial revascularization) and improvement of the inflammatory profile, effectively forwarding the individuals to the rehabilitation phase 2.


Eligibility criteria:
inclusion criteria: * be elective for the first cabg due to a previous ischemic event; * do not present other associated heart diseases; * absence of history of neuromuscular, autoimmune and infectious diseases; * age between 50 to 75 years; * signature of the informed consent term. * no hyperreactivity during the pre-intervention evaluation tests; * no chronic renal failure; history of malignant disease with life expectancy \<2 years; * no severe arrhythmias, angina pectoris, pulmonary embolism and thrombophlebitis; * do not have orthopedic limitations or any physical or mental limitation that prevents the proposed exercises from being performed; * present left ventricular ejection fraction (lvef) \> 40% in 48h after cabg, and * after the physical training period, individuals who have not completed a minimum of 80% of the protocol will be excluded from the sample due to refusal or withdrawal.

Keywords: coronary artery bypass grafting cardiorespiratory rehabilitation functional electrical stimulation inspiratory muscle training aerobic training isometric handgrip training functional capacity endothelial function cardiac function
neopep-s-based easydew md regen cream for radiotherapy subject after breast tumor resection

Conditions: Skin Lesion

Summary: this clinical study is conducted prospectively for 3 months after medical device treatment. it is a comparative clinical study of the leading control group.

subject is a patient who has a tumor removed from the breast and is receiving radiotherapy at the lesion. subjects (and/or legal representatives) have agreed in writing to participate in the clinical study. perform a post-screening test. evaluating the screening test results, meeting the selection criteria, and meeting the exclusion criteria. those who do not are registered for clinical research. * control group: physiogel skin stability intensive cream md (10 people) * study group: easydew md regen cream (20 people) the subjects of the clinical study are randomly assigned in a 2:1 ratio between the study group and the control group. in this case, apply the control medical device twice a day (morning and evening) to the radiation treatment area. apply it. in the case of the research group, easy dew md regen cream was applied to the radiotherapy site. apply an appropriate amount twice a day (in the evening) to ensure good absorption. the progress for three months after the application of medical devices for clinical research will be observed, and the subjects will be screening visit (visit1), medical device application day (visit2), medical device application, and medical device application. visit the research institution regularly for one month (visit3) and three months after application (visit4) for validity and to be evaluated for safety.

Eligibility criteria:
inclusion criteria: * adults over the age of 19 * the tumor in the breast area is resected and radiotherapy is planned, performed, or subjects with a history of irradiation * decide to participate in this clinical study arbitrarily and in the written informed consent a person to whom exclusion criteria: * when participating in a clinical study, the findings of radiation dermatitis in the area are shown * a person who shows signs of acute or chronic dermatological diseases * in situations where the requirements of a clinical study cannot be complied with * when the researcher's judgment determines that the participation of the study is inappropriate (e.g. kelloid personality)
reinforcement anastomosis with modified cyanacrylate in patients undergoing to oncologic colorectal surgery with colorectal anastomosis

Conditions: Colorectal Cancer

Summary: in colorectal surgery about 30% of postoperative mortality is attributed to anastomotic leak, whit an incidence range between 1.8% and 15.9%. preventing the anastomotic leak can therefore bring benefits to the patient and the health system. to date we have technologically advanced suturizers and the correct realization (well-vascularized margins, not in tension, etc.) remains crucial to prevent anastomotic dehiscence. experimental results demonstrate that modified cyanacrylate is a suitable potential "reinforcement" on intestinal anastomoses (manual or linear intra-corporeal). applied after mechanical anastomosis, it polymerizes in a short time, closing the spaces of the suture line between one point and the other, expressing an adhesive, hemostatic and sealing action on the tissues, also creating an effective antiseptic barrier towards of the most common infectious or pathogenic agents.


Eligibility criteria:
inclusion criteria: * informed consent * patients undergoing to oncologic colorectal surgery with colorectal anastomosis exclusion criteria: * refuse informed consent * patients undergoing to oncologic colorectal surgery without colorectal anastomosis
investigation of adults with congenital heart disease in the scope of the icf

Conditions: Congenital Heart Disease; ICF; Quality of Life

Summary: congenital heart disease (chd) is one of the common birth defects with a prevalence of approximately 1 in 1000 live births worldwide. while 15% of patients with chd reached adulthood in the past, this rate is close to 90% today thanks to advancing medicine and technology.as individuals with chd age, they may be affected by acquired cardiovascular risk factors common in the general population in addition to heart diseases such as arterial hypertension, obesity, and diabetes, increasing the risk of metabolic disease, stroke, and coronary artery disease. in addition to these risk factors, the disease affects both the social and familial environment of the patients. in addition to the mortality and morbidity of patients, which was the most important outcome measure in the past, quality of life has become the subject of current research. the international classification of functioning and health (icf) was adopted in 2001 for the use of a common, standard language and framework for describing health and health-related conditions, and is an international and standardized classification system that can evaluate functioning, disability and health holistically. there are no studies in the literature evaluating body structure, function and activity and participation in adults with congenital heart disease within the scope of icf. therefore, the aim of this study is; it is the evaluation of adults with chd according to icf sub-parameters (body structure and functions, activity and participation, and environmental factors) and the correlation of icf parameters with other evaluation methods.


Eligibility criteria:
inclusion criteria: * diagnosed with congenital heart disease * being between the ages of 18-65 * to have been informed about the study and given written consent to participate in the study. exclusion criteria: * having a neurological, orthopedic or any systemic disease, * presence of infection and malignancy, * cognitive, psychological and mental status are not suitable for evaluations, * to undergo another surgery other than cardiac surgery.

Keywords: congenital heart disease icf muscle strength physical activity quality of life
tracking physical activity for chronic pain management among older adults in detroit

Conditions: Chronic Pain

Summary: wearable, commercially-available physical activity monitors are being increasingly incorporated into chronic pain self-management interventions as a tool to help patients set goals and to tailor intervention content based on patient progress. yet older adults from resource-challenged communities may face significant barriers to using these monitors and reporting activity data. our pilot study will focus on wearable monitor use among older adults in detroit with chronic musculoskeletal pain, testing the feasibility and validity of various technology-based strategies for reporting daily step count data. the study will also assess whether six weeks of monitor use is associated with improvements in functioning, relative to a control group.


Eligibility criteria:
inclusion criteria: * age \> 60 years * ambulatory with or without assistive device * community living * have a sms-capable cell phone * internet access (via smartphone, in-home or elsewhere); * self-reported chronic musculoskeletal pain (pain in muscles or joints for \> 3 months) * \>4 (0-10 scale) average pain level over last week * \>1 day/previous 30 when pain made it difficult to do usual activities * ability to travel to study location in detroit for a one-time session exclusion criteria: * serious acute illness or hospitalization in last month * planned surgery in next month * severe cognitive impairment
ultrasound tomography using softvue in diagnosing women with breast cancer

Conditions: Breast Cancer

Summary: this clinical trial studies ultrasound tomography using softvue in diagnosing women with breast cancer. new diagnostic procedures, such as ultrasound tomography using softvue, may help find and diagnose breast cancer.

primary objectives: i. determine the in-vivo imaging potential of softvue through 3-dimensional (3-d) breast imaging. ii. acquire data for softvue evaluation from a cohort of 100 women receiving standard ultrasound (us) evaluation as follow-up to mammographic or palpable abnormalities and construct reflection, sound speed and attenuation images with softvue. iii. evaluate the ability of softvue to detect dominant breast findings (i.e. major normal landmark architecture) or masses previously identified with standard diagnostic evaluation (palpation, mammography, standard us) using standard clock position and radial distance measurements from the nipple. iv. conduct tomographic (i.e. slice-by-slice) comparison of softvue with magnetic resonance imaging (mri) findings from a subgroup of 50 patients. outline: patients undergo ultrasound tomography using softvue. some patients also undergo mri of the breast.

Eligibility criteria:
inclusion criteria: * scheduled for mammogram, breast ultrasound and/or breast mri * breast size less than 22 cm diameter (ring diameter is 22cm) * able to read or understand and provide informed consent * weight \< 350lbs (patient bed max weight) * non-pregnant and non-lactating * no open breast or chest wounds * no active skin infection * no serious medical or psychiatric illnesses that would prevent informed consent
food and microbiome longitudinal investigation (famili)

Conditions: Cancer; Cardiovascular Diseases

Summary: the nyu human microbiome study cohort is designed to improve understanding of the role of human microbiome in health and disease. this study will serve as a critical nyu biorepository resource for research on human genetics and the microbiome in health and disease


Eligibility criteria:
inclusion criteria: * age \> 40 exclusion criteria: * use of long term antibiotics. * pregnant
screening patients with fabry disease in patients with hypertrophic cardiomyopathy or left ventricular hypertrophy

Conditions: Hypertrophic Cardiomyopathy; Left Ventricular Hypertrophy; Fabry Disease

Summary: the purpose of this study was to understand the epidemiological status of fabry in patients with hypertrophic cardiomyopathy or left ventricular hypertrophy through multi-center early identification of high-risk patients in cardiology according to high-risk profiles, supplemented by dbs (dried blood disc) screening tools, and to explore the screening and diagnosis methods of patients with fabry disease in cardiology, so as to promote the early identification, diagnosis and treatment of fabry in cardiology.


Eligibility criteria:
inclusion criteria: * meet diagnostic criteria for hypertrophic cardiomyopathy (hcm) in adults (age ≥ 18 years):imaging of one or more left ventricular segments reveals a maximum end-diastolic ventricular wall thickness of ≥15 mm or end-diastolic ventricular septal thickness or posterior left ventricular wall thickness of ≥13 mm on either cardiac imaging at rest. exclusion criteria: * 1. identification of hypertrophic cardiomyopathy caused by mutations in pathogenic genes; 2. identify the cause of left ventricular hypertrophy (lvh); 3. aortic valve or mitral valve lesions that can cause hemodynamic changes.
a study of two methods for determining the renal threshold for glucose in patients with type 2 diabetes mellitus

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to compare the results from two methods used to determine the renal threshold for glucose excretion (defined as the lowest plasma glucose concentration at which appreciable amounts of glucose appear in the urine) in untreated patients with type 2 diabetes mellitus and in patients with type 2 diabetes mellitus who are treated with 100 mg once-daily canigliflozin for 8 days.

this is an open-label (patients will know if they are receiving treatment and the identity of the treatment) study that will compare renal threshold of glucose (rtg) values obtained by 2 different methods: an established method (ie, the stepwise hyperglycemic clamp method) and a new method (the mixed meal tolerance test \[mmtt\] method). the rtg is defined as the lowest plasma glucose concentration at which appreciable amounts of glucose appear in the urine. each method for determining the rtg value will be performed in untreated patients with type 2 diabetes mellitus (t2dm) and in patients with t2dm who are treated with canagliflozin 100 mg once daily for 8 days. canagliflozin (a sodium-glucose cotransporter 2 inhibitor) is currently under development to lower blood sugar levels in patients with t2dm. patients will not take study drug (canagliflozin 100 mg overencapsulated tablets) in part 1 of the study. in part 2 of the study, patients will take study drug once daily on study days 1 through 8.

Eligibility criteria:
inclusion criteria: * patients with t2dm who are not receiving treatment with any anti-hyperglycemic agents (ahas) for at least 12 weeks, or who are receiving treatment with a stable dose and regimen of metformin monotherapy for at least 12 weeks and have a hemoglobin a1c (hba1c) in the range of \>=7% to \<=10% exclusion criteria: * history of type 1, "brittle" diabetes or secondary forms of diabetes * history of 1 or more severe hypoglycemic episodes * history of diabetic complications considered to be clinically significant by the investigator * history of or current illness considered to be clinically significant by the investigator

Keywords: canagliflozin renal threshold for glucose pharmacodynamics
validation of the utility of an artificial system for the large-scale screening of scoliosis

Conditions: Orthopedic Disorder of Spine; Artificial Intelligence; Scoliosis

Summary: traditional school scoliosis screening approaches remains debatable due to unnecessary referal and excessive cost. deep learning algorithms have proven to be powerful tools for the detection of multiple diseases; however, the application of such methods in scoliosis screening requires further assessment and validation. here, the investigators develop an artificial system for the automated screening of scoliosis using disrobed back images, and conduct clinical trial to validate if the diagnostic system can offsetting the shortcomings of human doctors.


Eligibility criteria:
inclusion criteria: * 1.patients included both pretreatment back photos and whole spine (c7-s1) standing x-ray or ultrasound images (for healthy population); 2. all the documents are clear to be recognized by naked eyes; 3. back photos and are taken at the same time (not \>1month); 4.patients were consider as idiopathic scoliosis according to clinical photos. exclusion criteria: * 1. patients were considered as non-idiopathic scoliosis for obvious abnormal features of trunck,such as cafe-au-lait spots for neurofibromatosis, spider finger, abnormal hair spot of back, pelvic tilt, lower limb discrepancy and so on; 2.the taken time between back photo and x-ray or ultrasound was more than 1month; 3.the clinical photos and images were not clear; 4. the x-ray film or ultrasound images not including whole spine (c7-s1).

Keywords: orthopedic disorder of spine
the role of vitamin d supplementation on well being and symptoms of depression during the winter season in health service staff

Conditions: Seasonal Affective Disorder; Vitamin D3; Mental Health; Dietary Supplement

Summary: the purpose of this study is to investigate whether vitamin d3 (70 micrograms) is better than placebo in preventing depression symptoms among employees in health care

vitamin d3 is produced in the skin after exposure to ultraviolet b light from the sun. vitamin d3 is metabolised sequential in the liver into 25-hydroxy-vitamin d \[25(oh)d\], which is the storage form of vitamin d in the body, and then in the kidney into the steroid hormone, 1a,25-dihydroxyvitamin 1a,25-dihydroxyvitamin d \[1,25(oh)2d\]. at higher latitudes ultraviolet b light is stopped by the atmosphere during winter season. half of danes have low levels of \[25(oh)d\] in the blood and especially in the early spring months the levels of \[25(oh)d\] are low. in addition, vitamin d3 is absorbed through the gut from vitamin d-rich food sources. but several studies show that it is not possible through a recommended diet, which consists of 300 g of fish per week to consume adequate amounts of vitamin d3. new research suggests link between vitamin d3 and brain function.in the central nervous system (cns) there are specific nuclear receptors for 1,25(oh)2d (vdr) and the enzymes necessary for the hydroxylation of 25(oh)d to 1,25(oh)2d are also present in cns. in clinical studies, low serum levels of 25(oh)d, have been associated with reduced cognitive function, anxiety and depression. the objective of this randomized clinical trial is to investigate whether indoor employees, with tendency to depressive symptoms in the winter season, should be offered vitamin d3 supplements during the winter season, or it has no significance in relation prevent depressive symptoms. the study is carried out in the winter season in the region of southern denmark for 12 weeks and offered to health service staff, who have a tendency for depressive symptoms in the winter season.

Eligibility criteria:
inclusion criteria: * health service staff and employee in the region of southern denmark. * tendency to depressive symptoms in the winter season spaq\>7. exclusion criteria: * clinical diagnosis sarcoidoses * tuberculosis * bipolar affective disorder * schizophrenia * hypercalcemia * hyperphosphatemia * pregnancy * hyperparathyroidism * reduced kidney function

Keywords: spaq sigh-sad hamilton 29 vitamin d3 p25(oh)d