Kornimate/medical-research-clean huggingface dataset:
dry eye treatment with artificial tears

Conditions: Dry Eye

Summary: dry eye is a chronic irritating eye condition that affects many people, caused by poor tear quality and insufficient quantity. treatments are traditionally in the form of artificial tears applied to the ocular surface. however, there is little evidence in the scientific literature that demonstrates their efficacy relative compared to each other, nor how to decide which one might be most effective for an individual patient. therefore the investigators aim to examine the efficacy of different classes of artificial tears (those designed to increase viscosity, reduce evaporation or to mimic the component balance of the natural tears). in addition, the investigators also aim to determine how the treatment preferred by an individual could potentially have been predicted from their baseline condition.

the efficacy of different classes of artificial tears (non-pharmaceutical) will be examined in patients that report dry eyes by prescribing each category of treatment \[0.40% sodium hyaluronate (clinitas soothe), 0.15% sodium hyaluronate (hyabak), 0.25% carboxymethylcellulose, electrolyte balanced (theratears), and phospholipid liposomal spray (tears again)\] for a month in turn following a short wash-out period and to examine their tear film and ocular surface after each one.

Eligibility criteria:
inclusion criteria: * subjective symptoms indicative of dry eye exclusion criteria: * diabetes * sjögren's syndrome * recent ocular infection * hay fever * used any eye drops or ocular medications, * were currently on medications known to affect the eyes * wore contact lenses * were pregnant.
feeding and wellness among late preterm infants

Conditions: Late Preterm Infant

Summary: 1. the first aim of this proposal is to pilot the feasibility of weekly phone monitoring of infant feeding and illness patterns in a socio-economically and racially diverse population. specifically, the investigators aim to estimate the rate of group loss to follow up from birth to 13 weeks (3 months) of age with weekly phone interview of mothers of late preterm (lpt, gestational age 34 0/7- 36 6/7 weeks gestation) infants. 2. the second aim is to describe breastfeeding and formula feeding practices, and rates of illness and post-discharge hospital care utilization, through age 13 weeks (3 months) among late preterm infants born at macdonald women's hospital. the investigators estimate that the rate of exclusive breastfeeding among lpt infants at 3 months of age is less than the documented rate of 37% for all infants in cuyahoga county.

late preterm infants (lpt, gestational age 34 0/7 - 36 6/7 weeks) are the largest proportion of all preterm (less than 37 weeks gestation) infants. recent evidence finds an increased risk of early post-discharge morbidity and re-hospitalization among lpt as compared to full term infants, which is linked to breastfeeding, specifically to early lactation failure and decreased breast milk intake. accurate and inexpensive methods to collect data on rates of breastfeeding and early morbidity among lpt infants are critical to design, implementation and monitoring of effective interventions. this pilot study evaluates the feasibility of weekly phone calling in a racially and socioeconomically diverse population of mothers of lpt infants.

Eligibility criteria:
inclusion criteria: * mothers of singleton lpt (late preterm, gestational age 34 0/7- 36 6/7 completed weeks) infants exclusion criteria: * exclusion criteria for mothers include positive maternal drug screen for drug of abuse * age \< 18 years, or per caregiver discretion mother is not appropriate for study. * exclusion criteria for infants include custody under contention, positive screen for maternal drugs of abuse, or major congenital anomaly or congenital infection.

Keywords: late preterm infant breastfeeding formula feeding rehospitalization telephone
pediatric telephone center board 15

Conditions: Emergencies; Pediatric ALL; Response, Acute Phase

Summary: this study evaluates the follow-up of advices given in a urgent medical aid service (samu 29) for every pediatric's emergency call under 15yo and try to evaluate the adhesion's factors.

many of pediatric's medical emergency are followed by a medical advice in a urgent medical aid service (samu). this advices could be medications advices, to see a general praticionner the same day or later, or to consult in an emergency department. but the rate of advices really followed by callers is unknown. this study evaluate by who, when and why this advices are followed or not.

Eligibility criteria:
inclusion criteria: * all emergency calls at samu 29 for under 15yo childs * medical advices were given by the physician (medication at home or consult in an emergency department or consult the general praticionner the same day or later. exclusion criteria: * all emergency calls at samu 29 for upper 15yo childs * participation opposition. * need for an ambulance or an emergency medical team at home

Keywords: urgent medical aid service (samu) pediatric
the study on the accuracy of peri-implant probing and related influencing factors

Conditions: Peri-Implantitis; Diagnosis

Summary: the aim of the diagnostic accuracy study was to compare the diagnostic accuracy of probing depth before (ppd-1) and following (ppd-2) the removal of prothesis in identifying the presence of peri-implantitis and assess the factors influencing peri-implant probing.

this study aims to design a diagnostic accuracy study to compare the peri-implant probing depth and bleeding on probing before and after crown removal. it will explore the impact of prosthetic design on the accuracy of peri-implant probing and its diagnostic accuracy, and provide clinical recommendations on whether the prosthesis should be removed prior to peri-implant probing.

Eligibility criteria:
inclusion criteria: 1. age greater than 18 years. 2. the implant has completed osseointegration and has undergone final restoration for at least one month. 3. the final restoration needs to be removed or retrieved for various reasons. exclusion criteria: * patients with serious systemic diseases, severe intraoral infections, severe mental disorders, pregnancy/lactation in women, or other conditions that make oral treatment operations unsuitable. * history of crown removal or re-restoration within the past month prior to the visit. * the prosthesis has fallen off or is severely damaged and has lost its original form before the visit. * the prosthesis cannot be completely removed. * refusal to participate in this study.
different oils for frying and endothelial function

Conditions: Endothelial Dysfunction

Summary: the purpose of this study is to compare the effects of the consumption of different oils (olive oil, sunflower oil, sunflower plus dimethyl-polysiloxane, sunflower plus phenols) previously submitted to heating in postprandial endothelial function, inflammation and oxidative stress in healthy young men.

to determine whether the consumption by healthy persons of an oil exposed to high temperatures, designed to have a composition of healthy fats (predominantly monounsaturated fats and with less than 10% palmitic acid) and to contain an abundance of antioxidants typically found in olive oil (phenolic compounds), will improve the vasodilatory response that depends on the endothelium, and buffer the inflammatory and postprandial oxidative response that is produced by the oils that are being used ever more frequently for frying purposes (sunflower oil and oil to which butylated hydroxytoluene (bht) has been added), using virgin olive oil exposed to the same heating regime as a reference oil.

Eligibility criteria:
inclusion criteria: * investigators will select obese people (bmi ranged 25 to 40). exclusion criteria: * evidence of malignancy or severally ill (life expectancy lesser than 5 years).

Keywords: phenols laser-doppler olive oil sunflower oil dimethylpolysiloxane postprandial inflammation oxidative stress
effect of collagen versus prf on bma osteogenic potential

Conditions: Bone Loss, Alveolar

Summary: utilization of collagen vs prf membrane over the graft following sinus lift procedure and before suturing

assessment of the effect of membrane overlying bone marrow aspirate concentrate - bovine graft mixture in sinus lift procedure

Eligibility criteria:
inclusion criteria: * patients who has as deficient as 4 mm vertical bone height in posterior maxilla that need bone augmentation before delayed implant placement. * highly motivated patients * age more than 18 years exclusion criteria: * patients suffering from any systemic disease or those under any medication that may interfere with normal bone healing. * patients suffering from any sinus pathosis. * patients with conditions that could potentially compromise bone marrow ( bm)quality, including history of hematologic malignancy, current chemotherapy, bm suppressive and anti-platelet medications, previous bm aspiration, or acute illness. * heavy smoker (\> 20 cigarettes daily)
rhdnase and biodistribution of pmn serine proteases in cystic fibrosis sputum

Conditions: Cystic Fibrosis

Summary: serine proteases belonging to the elastase family are mainly responsible for lung tissue destruction as observed during cystic fibrosis. but anti-inflammatory therapies based on systemic or aerosolized protease-inhibitors administration, have not given the expected results until now. one reason would be the impaired access of therapeutic inhibitors to their molecular targets. it was recently shown that neutrophils actively secrete neutrophil extracellular traps (nets) made of dna that binds cationic proteases among other molecules. nets together with dna passively released from dead neutrophils contribute to the viscosity of cf expectorations which explains that rhdnase treatment fluidifies expectorations and improves the patient status. preliminary experiments in our laboratory have shown that dna degradation was associated with a significant increase of proteolytic activity in the sputum soluble fraction. however the efficacy of exogenous inhibitors is also improved in these conditions. using the specific substrates and methodologies that we developed previously to measure cell-surface associated proteolytic activities, we will study the effects of dnase on the activity of individual proteases, their biodistribution in sputum and their regulation by potential therapeutic inhibitors. enzymatic, immunochemical and microscopic (confocal and scanning) techniques will first be used for ex vivo studies on sputa freshly collected at the adult and paediatric crcm in tours, then on sputa from patients before and after administration of aerosolized rhdnase. we hypothesize that a better understanding of the biodistribution of neutrophil serine proteases and especially their binding to dna will help designing new therapeutic strategies that facilitate inhibitor access to their protease targets.


Eligibility criteria:
inclusion criteria: * cystic fibrosis disease * with rhdnase treatment exclusion criteria: * acute push of the bronchopulmonary attack or hospitalization for treatment of the disease during 2 weeks previous * exposure to a antibiotherapy or treatment by corticoids

Keywords: cystic fibrosis
the physiological impact of n95 masks on medical staff

Conditions: Hypoxemia; Hypercapnia

Summary: wearing n95 masks may have adverse physical effect on medical staff

wearing n95 masks results in hypooxygenemia and hypercapnia which reduce working efficiency and the ability to make correct decision. medical staff are at increased risk of getting 'severe acute respiratory syndrome'(sars), and wearing n95 masks is highly recommended by experts worldwide. however, dizziness, headache, and short of breath are commonly experienced by the medical staff wearing n95 masks. the ability to make correct decision may be hampered, too. the purpose of the study was therefore to evaluate the physiological impact of n95 mask on medical staff.

Eligibility criteria:
inclusion criteria: * medical staff exclusion criteria: * pregnancy

Keywords: n95 mask medical staff hypoxemia hypercapnia neurological study
a study to investigate apl-4098 alone and/or in combination with azacitidine in r/r aml and high-risk mds

Conditions: Acute Myeloid Leukemia Refractory; Myelodysplastic Syndrome Acute Myeloid Leukemia; Myelodysplastic Syndrome With Excess Blasts; Acute Myeloid Leukemia, in Relapse

Summary: this is an open-label, phase 1/2 study to determine the safety, tolerability, and efficacy of apl-4098 alone and/or in combination with azacitidine for the treatment of relapsed or refractory (r/r) acute myeloid leukemia (aml), myelodysplastic syndrome (mds)/aml and mds-excess blasts (eb). participants with the mds-eb subtype will be eligible for the phase 1 part of the study only.


Eligibility criteria:
inclusion criteria: * 18 years or older * confirmed diagnosis of relapsed refractory acute myeloid leukemia (r/r aml), myelodysplastic syndrome (mds)/ aml, or mds-excess blasts (mds-eb) with the following characteristics: - r/r aml (primary or secondary, including treatment-related), participant is intolerant to, or considered ineligible for available therapies known to provide clinical benefit. * wbc count ≤ 25,000/microliter * ecog performance status of ≤ 2 * weight ≥ 40kg * female participants of childbearing potential must have negative serum pregnancy test at screening; must not plan to become pregnant or have ova harvested or breastfeed while on study; must we willing to use specific contraception or avoid intercourse * male participants must be willing to use specific contraception and not plan to impregnant a female partner or donate sperm while on study * participant must be willing and able to provide written informed consent and to comply with the requirements of the trial exclusion criteria: * certain prior therapies such as: received an allogeneic stem cell transplant within 6 months of screening, received an autologous stem cell transplant within 3 months of screening, received any anti-cancer treatments within 2 weeks of cycle 1 day 1, prior radiation therapy within 4 weeks of screening * certain medical conditions such as: other malignancies, myocardial infarction within 6 months of screening, symptomatic congestive heart failure, uncontrolled active infection, history of arterial thrombosis within 6 months of screening * diagnostic assessments: left ventricular ejection fraction \ 470msec, aspartate aminotransferase and/or alanine aminotransferase \> 3 x upper limit of normal (uln), total bilirubin \> 1.5 x uln, calculated or measured creatinine clearance \< 45 ml/minute (multiply by 0.85 if female) * infectious disease: hiv positive, active hepatitis b and/or c
impact of fto gene variation on body composition, lipid profile, insulin resistance, advanced glycation end-products and ghrelin levels in response to hypocaloric, protein rich-diet

Conditions: Obesity; Insulin Resistance; Dyslipidemias; Advance Glycation; Inflammation

Summary: obesity is a widespread disease that basically develops from unhealthy lifestyle and genetics. the fat-mass and obesity associated (fto) gene affects appetite and energy intake of the body, thus elevating fat mass and body weight. the single nucleotide polymorphism (snp) rs9939609 of the fto gene is a common variant in different ethnic groups, and its a allele is associated with increased body mass and waist circumference. hence, the carriers of rs9939609 snp are prone to weight gain if a healthy diet and lifestyle are not maintained. similarly, high levels of serum cholesterol and triglycerides, while low levels of high-density lipoproteins are observed in carriers of rs9939609 aa genotype. for individuals having fto rs9939609 a allele, consumption of hypocaloric diets (1500 kcal/day) consisting of high protein foods up to 25-30% of total daily energy intake might help reduce body weight. however, weight loss tends to vary in individuals after consuming the same diet under similar environmental conditions, so it is important to know the effect of different genotypes that might cause this variation. the study aimed to genotype overweight and obese adults for fto rs9939609 polymorphism and to determine the effect of this polymorphism on body weight, bmi, waist and hip circumferences, lipid profile, insulin sensitivity, ghrelin levels, inflammatory markers and advanced glycation end-products in these individuals after consumption of a hypocaloric, high-protein diet for 4 weeks.


Eligibility criteria:
inclusion criteria: * 1overweight (bmi ≥ 25kg/m2) and obese (bmi ≥ 30kg/m2) individuals. * both genders. * age 18-50 years. exclusion criteria: * children, pregnant and lactating women * individuals taking medication for weight loss or undergoing any other weight loss dietary intervention. * individuals having lost more than 5 pounds in the past three-month period. * patients with any psychiatric disorders, heart, liver, kidney disease, diabetes or abnormal thyroid function.

Keywords: satiety food intake high protein diet obesity fto rs9939609 ghrelin carboxymethyl lysine interleukin-6
sensimed triggerfish safety and tolerability

Conditions: Glaucoma

Summary: the purpose of this investigation is to study the safety and tolerability of sensimed triggerfish, a soft contact lens-based device intended to continuously record relative changes in intraocular pressure (iop). the investigation enrols glaucoma patients and glaucoma suspects. all subjects receive two 24-hour recording sessions with the device in an ambulatory setting and at weekly interval. the level of discomfort in the study eye after 24 hours and side effects are the main endpoints of the investigation.


Eligibility criteria:
inclusion criteria: * subject is able to comply with the study procedures * subject is 18-80 years old * glaucoma patient, with glaucomatous optic neuropathy based on clinical assessment of stereoscopic optic disc photographs and/or repeatable abnormal standard automated perimetry (sap) visual fields at baseline, defined as a pattern standard deviation with p\<0.05 or a glaucoma hemifield test "outside normal limits * glaucoma suspect, with suspicious optic disc appearance (as determined by subjective assessment on the baseline visit) or elevated iop (\>21 mmhg) but normal and reliable sap visual fields at baseline * subject has consented to be in the trial and signed informed consent is available before any study related procedures are carried out * visual acuity of 20/200 or better in the study eye * ability of subject to understand the character and individual consequences of the study * for women with childbearing potential, adequate contraception exclusion criteria: * subjects with contraindications for wearing contact lenses * severe dry eye syndrome * keratoconus or other corneal abnormality * conjunctival or intraocular inflammation * eye surgery prior to and throughout the study, except prior uncomplicated cataract surgery a minimum of 3 months prior to the investigation * full frame metal glasses during sensimed triggerfish® recording * known hypersensitivity to silicone, plaster or ocular anesthesia * pregnancy and lactation * simultaneous participation in other clinical studies
heat therapy and cardiometabolic health in obese women

Conditions: Obesity; Polycystic Ovary Syndrome; Prehypertension; PreDiabetes; Cardiovascular Risk Factor; Metabolic Syndrome

Summary: traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression. for example, the relative risk of fatal heart disease is 50% greater in obese, diabetic women as compared to their male counterparts, and women appear to respond differently to lifestyle interventions such as exercise compared with men. chronic passive heat exposure (hot tub use) provides alternative or supplemental therapeutic potential for improving cardiovascular and metabolic health in obese women. in addition, passive heat exposure may offer specific cellular protection from stresses like a lack of blood flow (ischemia), which is the primary cause of fatal coronary heart disease. this study is investigating the possible cardiovascular and metabolic health benefits of chronic passive heat exposure, and whether regular hot tub use (3-4 days per week for 8-10 weeks) may reduce obese womens' cardiometabolic risk. the investigators are examining cardiovascular health through blood pressure, blood vessel stiffness, sympathetic ('fight or flight') activity, and responsiveness to stresses like increased or decreased blood flow. the investigators are also examining metabolic health through an oral glucose tolerance test and a subcutaneous fat biopsy. the goal of this research is to develop a therapy targeted toward the specific health needs and complications of obese women, in an effort to improve cardiovascular and metabolic health and provide therapeutic alternatives in this high-risk population.


Eligibility criteria:
inclusion criteria: * age 18-40 * body mass index (bmi) between 30-45 kg/m2. * willing to maintain consistent diet and activity patterns through the study * willing to refrain from food, physical activity, supplements, and medications as required before testing days * willing to refrain from blood donations over the course of the study exclusion criteria: * overt cardiovascular disease or diabetes * medications that affect blood vessel function (i.e. spironolactone), insulin sensitivity (metformin), or blood coagulation (i.e. warfarin) * recent rectal, anal, or vaginal surgery * pregnant, breastfeeding, or trying to conceive within 6 months.

Keywords: heat therapy blood pressure oral glucose tolerance test adipose tissue muscle sympathetic nerve activity
safety and effectiveness of azli (an inhaled antibiotic) in adults with non-cystic fibrosis bronchiectasis

Conditions: Bronchiectasis

Summary: the air-bx1 study enrolled people with non-cystic fibrosis (non-cf) bronchiectasis and gram-negative airway infection. participants received two 28-day courses of either aztreonam for inhalation solution (azli) or placebo taken 3 times a day. each course was followed by a 28-day off-drug period. following the two blinded courses, all participants received a 28-day course of open-label azli then were followed for an additional 56 days.


Eligibility criteria:
inclusion criteria: * male/female 18 years or older with non-cf bronchiectasis * chronic sputum production on most days * positive sputum culture for gram-negative organisms * must have met lung function requirements exclusion criteria: * history of cf * hospitalized within 14 days prior to joining the study * previous exposure to azli * pregnant, breastfeeding, or unwilling to follow contraceptive measures for the study * must have met liver and kidney function requirements * continuous oxygen use of greater than 2 liters per minute (supplemental oxygen with activity and at night was allowed) * treatment for nontuberculous mycobacteria infection or active mycobacterium tuberculosis infection within 1 year of enrollment * other serious medical conditions.