Kornimate/medical-research-clean huggingface dataset:
ondansetron in treatment resistant obsessive compulsive disorder (ocd)

Conditions: Obsessive Compulsive Disorder

Summary: given that 5-ht3 receptors are indirect inhibitors of cortico-mesolimbic da release, the 5-ht3 receptor antagonist ondansetron augmentation might potentially have efficacy in the treatment of resistant obsessive comulsive disorder (ocd) patients on combined sris and antipsychotics.

method: fourteen patients with a dsm-iv diagnosis of treatment resistant ocd, under stable treatment with ssri's and neuroleptic augmentation will enter an 12-week single blind trial of ondansetron initiated at a dose of 0.25 mg twice daily for 6 weeks, that will be titrated to 0.5 mg twice daily for 6 weeks.

Eligibility criteria:
inclusion criteria: 1. adults aged 18 to 55 2. a yale-brown obsessive-compulsive scale (y-bocs) score of ≥ 20 after ≥ 12 weeks of treatment with an established effective dose of an selective serotonin reuptake inhibitors or clomipramine and after ≥ 10 weeks of augmentation treatment with antipsychotics (risperidone at least 2 mg/day quetiapine at least 150 mg/day; olanzapine at least 5mg/day; haloperidol titrated at least 10 mg/day; aripiprazole at least 10 mg/day) exclusion criteria: 1. a history of alcohol or substance abuse 2. current severe depressive symptoms, bipolar disorder, panic disorder, schizophrenia, or other psychiatric conditions 3. heart disease, arrhythmia, liver problems, including cirrhosis, seizures, glaucoma or serious medical disease 4. hoarding as only obsessive compulsive symptom 5. women of childbearing potential not using a medically acceptable contraceptive method.

Keywords: obsessive compulsive disorder 5-ht3 ondansetron
impact of a child-parent preoperative accompanying procedure on the anxiety of children aged 5 to 12 with scheduled surgery

Conditions: Anxiety

Summary: in france, during surgery, only 4% of parents are present at induction, most often for children with disabilities with iterative interventions. some studies have shown that the presence of parents during induction decreases the anxiety of children, while others do not. their conclusions all advocate preparing parents for this presence in the operating room in an accompanying course.


Eligibility criteria:
inclusion criteria: * 5 to 12 year olds requiring scheduled surgery * scheduled outpatient or weekly hospitalization. * anesthesia envisaged by inhalation induction * agreement of parents (and child according to age). * even parent (s) present at pre-anesthesia and on the day of surgery exclusion criteria: * child with previous surgery * parent (s) of a child who has already had surgery * parent (s) or child unable to follow the whole procedure (autism, blindness ...)
improving blood glucose control with a computerized decision support tool: phase 2

Conditions: Critically Ill; Hyperglycemia

Summary: the purpose of this study is to: 1. introduce the refined, validated, and safe computerized bedside decision support tool for blood glucose management in critically ill adult and pediatric icu patients that was studied in phase 1 into a second group of naïve icus, none of which participated in eprotocol-insulin development, refinement or validation 2. monitor how often low blood sugar levels occur during use of the bedside tool. 3. determine how the computerized tool effects the workload of the icu nurses.

in the current second phase of this project (phase-2), we will introduce the refined, validated, and safe eprotocol-insulin into a second group of naïve icus, none of which participated in eprotocol-insulin development, refinement or validation. our primary goal in this second phase is to determine the feasibility of exporting this tool to naïve icu environments. in this second phase we will also compare the effects of the eprotocol-insulin and ordinary care approaches to glucose control on the bedside nurse's experience. this second phase will be a prospective cohort study. we will determine the feasibility of distributing eprotocol-insulin and will further validate eprotocol-insulin in \>4 adult and \>4 pediatric icus. if necessary we will modify eprotocol-insulin with an iterative refinement process, with institutional review board (irb) and independent data and safety monitoring board (dsmb) oversight. eprotocol-insulin will be considered refined if \>90% of the instructions are accepted and if the percent of glucose values between 70 and 110 mg/dl (3.9-6.1 mmol/l) are equivalent to our phase-1 refinement and validation experience of 46%%, and if the rate of glucose values \< 40 mg/dl (2.2 mmol/l) is less than 0.5% of glucose measurements.

Eligibility criteria:
inclusion criteria: 1. pediatric icu: proposed indications by pediatric clinicians at participating icus for glucose control in their icus would include patients who require mechanical ventilation for greater than 24 hours and/or require a vasoactive infusion (e.g. dopamine \>3 mg/kg/min, dobutamine, epinephrine, or vasopressin). 2. adult icus: proposed indications by clinicians in participating icus for glucose control in participating adult icus include critically ill patients with an anticipated icu length of stay of 3 or more days. exclusion criteria: 1. pregnancy (negative pregnancy test required for females of child-bearing age) 2. age less than one month 3. inborn errors of metabolism that the clinician suspects will affect glucose homeostasis 4. acute or chronic liver disease with any documented episode of blood or plasma glucose \<60 mg/dl within the 24 hours prior to study entry 5. diabetic ketoacidosis (critically ill patients with insulin dependent diabetes not in ketoacidosis will be eligible if attending physicians intend to use intravenous insulin as part of ordinary care) 6. severe chronic liver disease (child-pugh score \>10)

Keywords: glucose insulin computer critical care
the effect of foot massage in patients undergoing hemodialysis

Conditions: Nurse-Patient Relations

Summary: hemodialysis patients were divided into experimental and control groups. foot massage was applied to the patients in the experimental group. foot massage was not applied to the patients in the control group and routine nursing care was provided. pre-test, mid-test and post-test sleep quality and fatigue level scores of the patients were determined.

an experimental study design was used to conduct this research on 73 hemodialysis patients treated in a hemodialysis unit. the aim of this study is to investigate how foot massage applied to hemodialysis patients affects sleep quality and fatigue level.

Eligibility criteria:
inclusion criteria: * inclusion criteria were determined as follows: * having a psqi score of 5 points and above * receiving hd treatment for at least 6 months * having no neuropathy d) using no sleeping pills * having no communication problem * having full orientation and no psychiatric problems * having no conditions in the lower extremities and feet that would preclude massaging (no open wounds on the skin, orthopaedic and joint problems, oedema, abscess, infection, thrombophlebitis, deep vein thrombosis, thrombocytopenia, etc.) * having no history of allergy to the oil used for massage. exclusion criteria: exclusion criteria were determined as follows: * receiving less than 6 months of hd treatment * having communication problem * suffering from neuropathy * having incomplete orientation and any psychiatric problem * having a psqi score below 5 * having conditions in the lower extremities and feet that would preclude massaging (open wounds on the skin, orthopaedic and joint problems, oedema, abscess, infection, thrombophlebitis, deep vein thrombosis, thrombocytopenia, etc.) and having a history of allergy to the oil used for massage

Keywords: foot massage hemodialysis nursing sleep quality fatigue
expectations of patients in palliative situation

Conditions: Acute Myeloid Leukemia

Summary: to date, there is a lack of data about the benefit of blood cell transfusions for patients diagnosed of a hematologic malignancy who are not eligible for curative treatments. furthermore, there is no clear guideline about how to transfuse these patients and when the blood cell transfusions should be stopped. allogenic stem cell transplantation is nowadays the only curative treatment for patients with high-risk myeloid neoplasms. knowing that the median age at diagnostic for acute myeloid leukemia is 68 years and this incidence increases after 65 years, a lot of patients won't be eligible for allogenic stem cell transplantation. besides, patients with haematologic malignancies are prone to cytopenias, due to their pathology and the treatments used to limit its progression. a study estimate that these patients need a median of 4 blood cell units per month, and it is known that repeated transfusions are associated with an increased risk of dying in hospital. finally, it is estimate that there was a lack of 20 000 blood cell units in france in 2022. it therefore seems essential to find ways to optimize blood transfusion prescriptions in this population of patients who won't be eligible for curative treatments, with the main idea of maintaining or even improving their quality of life. the investigators will study the expectations of patients in palliative situation, paramedics and medical staff concerning blood cell transfusions, by asking them if whether or not they believe that the transfusion planed to be administer will benefit the patient. to do this, investigators will distribute questionnaires before each blood cell transfusions to patients who will be included, to the paramedic who administered the transfusion and to the physician who prescribed the transfusion. it is to investigators knowledge the first study to compare the expectations of patients in palliative situation, paramedics and medical staff concerning blood cell transfusions in hematology department, and follow the evolution of these expectations prospectively.


Eligibility criteria:
inclusion criteria: * patients aged 18 years or more and * diagnosed of an intermediate or high-risk acute leukemia and not eligible for allogenic stem cell transplantation or * diagnosed of a high-risk myelodisplasic syndrome and not eligible for allogenic stem cell transplantation or * diagnosed of an intermediate or high-risk myelofibrosis and not eligible for allogenic stem cell transplantation or * diagnosed of a chronic myeloid leukemia in blast crisis phase and not eligible for allogenic stem cell transplantation or * relapsing after allogenic stem cell transplantation and not eligible for a second allogenic stem cell transplantation exclusion criteria: * patients who can't read * patients who can't write * patients who can't express their consent

Keywords: haematology palliative situation
written behavioural persuasion technique intervention for hypertension management

Conditions: Hypertension; Behavior and Behavior Mechanisms

Summary: this study aims to examine the feasibility and effectiveness of written behavioural persuasion techniques intervention to encourage treatment initiation and follow-up for hypertension management among the untreated hypertension population of the seaco cohort.

each household is given a unique identifier called house_id in the seaco database. the randomisation will be computer-generated according to their house_id with a ratio of 1:1. during the house visit, participants' blood pressure will be taken three times, and the final reading will be the average of the second and third readings. participants will be assessed based on the inclusion and exclusion criteria, i.e., age 35 years and above, blood pressure reading and reported not being diagnosed with or treated for hypertension. at the end of the house visit, all participants will receive a standard referral leaflet, and participants randomised to the intervention group will receive an additional written behavioural persuasion leaflet.

Eligibility criteria:
inclusion criteria: * age 35 and above * systolic blood pressure equal to or more than 140 mmhg * diastolic blood pressure equal to or more than 90 mmhg * reported not being diagnosed with hypertension or not being treated for hypertension exclusion criteria: * involve in other research projects * decline to participate/reject
efficacy and safety of masitinib in the treatment of progressive multiple sclerosis

Conditions: Multiple Sclerosis, Secondary Progressive; Multiple Sclerosis, Primary Progressive; Multiple Sclerosis, Relapse Free

Summary: the purpose of this study is to compare the safety and efficacy of masitinib 6 mg/kg/day versus placebo in the treatment of patients with primary progressive multiple sclerosis or relapse-free secondary progressive multiple sclerosis.

masitinib is a selective tyrosine kinase inhibitor that is thought to exert a neuroprotective effect through its activity on mast cells and other non-neuronal cells of the central nervous system, with subsequent modulation of inflammatory and neurodegenerative processes. the objective of this study is to compare the efficacy and safety of masitinib at 4.5 mg/kg/day versus matched placebo, or masitinib at 4.5 mg/kg/day with a dose escalation to 6 mg/kg/day after 3 months of treatment versus matched placebo, in the treatment of patients with primary progressive multiple sclerosis or relapse-free secondary progressive multiple sclerosis. approximately 600 patients will be randomized into four treatment groups with a 2:2:1:1 design. the primary outcome measure is the expanded disability status scale (edss) after 96 weeks of treatment in the overall study population with subgroup analysis performed in stratum (primary progressive multiple sclerosis / secondary progressive multiple sclerosis).

Eligibility criteria:
main inclusion criteria: - patient suffering from either primary progressive or secondary progressive multiple sclerosis without relapse within 2 years before inclusion according to the revised mcdonald's criteria. main exclusion criteria: - patient suffering from a disease other than ms that would better explain the patient's neurological clinical signs and symptoms and/or mri lesions

Keywords: multiple sclerosis primary progressive relapse-free secondary progressive
behavior therapy prior to bariatric surgery

Conditions: Obesity

Summary: obesity is an ever increasing public health problem in this country. bariatric surgery is currently the most effective treatment for morbid obesity and two hundred thousand surgeries are performed in the united states each year. unfortunately, despite anatomically successful surgery, it is estimated that at most surgical centers about 30 percent of patients will not achieve significant weight loss following surgery. it has been proposed that participation in preoperative behavior therapy can enhance postoperative outcomes, although empirical evidence for this premise is lacking. the current study is a pilot project designed to conduct a prospective randomized trial to examine the impact of participation in a 12-week standardized preoperative behavioral weight management program on percentage of excess weight loss and psychosocial and medical outcomes at six months after roux-en-y gastric bypass surgery. the cost of bariatric surgery is not covered by this study and only patients local to the rochester, minnesota area are eligible to participate. it is hypothesized that patients who complete the 12-week behavioral program will experience greater weight loss and improved psychosocial and medical outcomes compared to controls.


Eligibility criteria:
inclusion criteria: * bmi between 40 and 60 * age 25 to 65 * ability to participate in weekly learn groups for 3 months at mayo clinic (local to the rochester, mn area) * seeking rygb procedure exclusion criteria: * patients seeking surgical revision of a previous bariatric procedure * diagnosis of schizophrenia * diagnosis of bipolar disorder * diagnosis of borderline personality disorder * non-local patients

Keywords: bariatric surgery behavioral weight management psychosocial outcomes following bariatric surgery
enhancing thoracolumbar burst fracture treatment

Conditions: Surgery

Summary: the optimal treatment for neurologically intact thoracolumbar fractures remains controversial. percutaneous pedicle screw fixation (ppsf) has been proposed for these fractures; however, achieving satisfactory reduction can be challenging. this study applied robot-assisted ppsf to enhance treatment outcomes.

the optimal treatment for neurologically intact thoracolumbar fractures remains controversial. percutaneous pedicle screw fixation (ppsf) has been proposed for these fractures; however, achieving satisfactory reduction can be challenging. this study applied robot-assisted ppsf to enhance treatment outcomes. the investigators retrospectively analyzed the medical records of 182 consecutive patients with thoracolumbar burst fractures treated with ppsf, with (n=88) and without (n=94) robotic assistance, at our hospital between april 2017 and june 2019. the participants were evaluated surgical time, intraoperative bleeding, radiation dosage, accuracy of screw placement, fractured vertebral height, cobb's angle, surgery efficacy (pain relief and limb function), and implant failure to assess the potential advantages of robot-assisted ppsf. robot-assisted ppsf for thoracolumbar burst fractures reduces surgery time and intraoperative bleeding, enhances screw placement accuracy, and achieves better reduction compared to the free-hand technique. this approach effectively prevents endplate collapse and recurrence of kyphosis post-surgery. however, functional recovery in the short term is similar between the two methods.

Eligibility criteria:
inclusion criteria: had thoracolumbar burst fractures classified as magerl type a3 underwent short segment posterior fixation (sspf) showed no signs of osteoporosis on dual-energy x-ray absorptiometry in patients older than 60 years. exclusion criteria: had fractures outside the t11-l2 range presented with old fractures, (iii) had a parker score ≥ 7 had multiple segment fractures had neurological deficiency caused by fractures had concomitant pain caused by spinal degeneration such as lumbar disc protrusion, spondylolisthesis, spinal stenosis, and/or scoliosis could not receive pedicle screw placement due to bilateral pedicle fractures with displacement had incomplete clinical data or were lost to follow-up

Keywords: thoracolumbar fractures percutaneous pedicle screw fixation robot-assisted endplate collapse
unilateral massage as a potential treatment for depression

Conditions: Depression

Summary: in depression, eeg studies have shown frontal asymmetry with relatively lower activity in the left hemisphere. in this study a moderate pressure massage will be conducted by a trained professional on one of the following conditions: the right side of the body, the left side of the body, or both sides of the body (a traditional massage on the back of the body) while eeg measurements of brain activity are recorded and mood ratings are obtained.


Eligibility criteria:
inclusion criteria: * medically and mentally healthy, right-handed participants will be eligible for participating in this study. the age range for enrollment in the study is not restricted by any variables but will be set between 18 and 50 years of age. exclusion criteria: * left-handed subjects, persons suffering acute or chronic mental illnesses and chronic illnesses (including autoimmune illnesses).

Keywords: unilateral massage depression
normative reference values of equilibrium coordination test among children

Conditions: Coordination Disorder, Developmental

Summary: a cross-sectional study will be conducted recruiting children of age group 8-15 years. pilot study has been conducted for the determination of the sample size. the calculated sample size has come out to be, n=378 which can be taken for males and females separately. stratified random sampling will be done according to age. child will be asked to perform all tests one by one and the time taken (in seconds) will be noted required to perform the tests. the mean of three readings will be obtained using a mobile-based stop watch.

756 children will be recruited of age group 8-15 years. five equilibrium coordination tests i.e. sideways walking, tandem walking, cross-stepping, heel walking and toe walking will be performed by each child and three readings will be recorded. mean of three readings will be considered as normative reference value of each test respectively.

Eligibility criteria:
inclusion criteria: * typically developing school-going children with age group between 8 and 15 years * both male and female * able to walk independently * able to follow verbal commands exclusion criteria: * any fracture of lower limb in last 6 months * any congenital anomaly affecting lower limb * any developmental disorder * any open wounds * those who are using any kind of assistive devices * any condition that affect the health status of the participants during the study

Keywords: children coordination normal range postural balance walking
a prospective study to evaluate revita dmr post market pilot clinical follow-up registry in patient with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the revita dmr post market pilot clinical registry is a post-market, prospective, observational, noninterventional clinical registry in patients with t2d in germany undergoing the revita procedure with the ce marked revita system (fractyl health, lexington, ma, usa) in accordance with its intended purposes. patient's participation in this study has no impact on his or her indication or opportunity to receive therapy. patients are to be treated in compliance with the current revita system's ifu of the ce marked revita system as well as according to medical society guidelines and physician discretion.


Eligibility criteria:
inclusion criteria: * signed and dated informed consent in accordance with gcp and local legislation * adults (≥18 years) with the diagnosis of t2d * bmi of \<=45 kg/m2 at the time of presentation/screening * t2d mellitus inadequately controlled on therapy (hba1c ≥7.0 and ≤10.0% \[53-86 mmol/mol\] at the time of initial presentation for screening and with the need for therapy escalation \[dose increase of existing therapy or additional prescription of insulin and/or oads or change of therapy regimen\]) to achieve the therapeutic hba1c target defined by the physician * treatment with oral and/or injectable glucose lowering medications and/or long-acting insulin therapy exclusion criteria: -

Keywords: type 2 diabetes dmr duodenal mucosal resurfacing revita
health related quality of life assessment in egyptian recipients after living donor liver transplantation

Conditions: Health Related Quality of Life

Summary: health related quality of life assessment in egyptian recipients after living donor liver transplantation

this study aims to evaluate:- 1. quality of life after ldlt in egyptian patients using short form 36 (sf - 36) score. 2. impact of post transplant medical and psychiatric complications on quality of life

Eligibility criteria:
inclusion criteria: * adult egyptian patients * 18-60 years old * patients transplanted for hcv related disease and /or hcc * informed consent exclusion criteria: * other etiologies for end stage liver disease (such as hbv and cholestatic liver disease and autoimmune hepatitis).

Keywords: health related quality of life (hrql) living donor liver transplantation(ldlt)