Kornimate/medical-research-clean huggingface dataset:
to assess the effectiveness of the intervention of the low-sodium diet in patients with hta

Conditions: Arterial Hypertension; Sodium Urine; Primary Care Center; Diet Habit

Summary: arterial hypertension is an independent vascular risk factor and a frequent reason for consultation in primary care. it generates high cardiovascular morbidity and mortality (stroke, heart disease, kidney failure and other diseases). moreover, given that it is a modifiable factor and that there are intervention and control measures that would lead to a significant reduction in cardiovascular incidence and morbimortality, it can be stated that ets is a major public health problem. the approach to this risk factor can be pharmacological and non-pharmacological. the non-pharmacological approach is based on lifestyle modification. among the measures aimed at modifying lifestyles is the restriction of daily intake of sodium in the diet. such restriction enhances the hypotensive effect of pharmacological treatment so that its application and intensification would delay the start of pharmacological therapy, as well as avoid the need to increase the dose of antihypertensive drugs or the number of drugs to be used for the control of hypertension. in relation to salt intake in the spanish population, the average is above the figures of less than 5 grams per day recommended by the who. sodium intake can be estimated by determining the 24-hour urine sodium concentration. in addition, there is a positive correlation between systolic and diastolic blood pressure figures and the excretion of sodium in urine.

in the present work, with a prospective cohort observational study design, it intends to assess the effectiveness of the use of an educational program based on the follow up of a hyposodium diet and assessed through the routine use of urine sodium monitoring of the hypertensive patient in the primary care setting, in order to optimize treatment, as well as to review the clinical control in this group of patients. on the other hand, it is intended to establish guidelines in the form of practical guidelines to provide with a standardized clinical approach for primary care centers.

Eligibility criteria:
inclusion criteria: * patients over 40 years old. * patients diagnosed with hta (according to criteria esc/esh 2018) in a pa consultation or through map at the health center. * in treatment with single, double or triple antihypertensive therapy. * patients with st figures ≥140. * patients with td numbers ≥90. * patients with stable antihypertensive treatment or without modifications in the treatment at least in the last month. * patients who commit to follow up the study. * patients who have given written informed consent. exclusion criteria: * patients with decompensated heart failure * severe renal failure. * decompensated liver disease. * taking non-insulin antidiabetic * hypertension of pharmacological origin and other causes.
research biobank from neuromuscular biopsy residues (in the context of care)

Conditions: Neuromuscular Diseases; Muscle; Nerve

Summary: neuromuscular diseases are rare diseases for which significant progress has been made in the context of diagnosis thanks to advances in molecular techniques, but the intimate mechanisms of lesion formation remain poorly understood. advances in cellular and molecular biology, the development of a few animal models, such as transgenic mice, which make it possible to mimic human pathology have made it possible to better understand the physiopathology of these diseases. however, they still do so very imperfectly and incompletely, making it even more necessary than ever to study diseased human muscle tissue to find new avenues of research or to confirm results obtained by experimentation. the purpose of this collection of tissue samples for neuro-muscular purposes is to collect such samples under the best conditions in order to promote basic and translational research on muscle diseases. this is why the chu de bordeaux wishes to keep the remainders of samples taken as part of the treatment to constitute a collection of biological samples and associated data kept according to quality standards and in compliance with the regulations in force.

the "colmyoneu" project is a project to collect leftover frozen neuromuscular biopsy samples from patients taken as part of their health care at the bordeaux university hospital for neuromuscular disease. its main objective is to store, under the conditions of the crb standard, residual biological samples from patients with neuromuscular symptoms.

Eligibility criteria:
inclusion criteria * patients treated at bordeaux university hospital (neurology services, neuropediatrics), rheumatology, medical genetics for suspected neuromuscular disease. * men and women are affected, adults and minors. exclusion criteria - no exclusion criteria
evaluation of the effects of acupuncture press needle in mild to moderate obstructive sleep apnea patients

Conditions: Apnea, Obstructive Sleep; Snoring

Summary: the aim of this study is to investigate the effects of acupuncture press needle in mild to moderate obstructive sleep apnea patients.

obstructive sleep apnea(osa) is characterized by multiple episodes of upper airway collapse during sleep and considered as a major health issue worldwide due to comorbidity with obesity, hypertension, diabetes and more advanced cardiovascular diseases. the noisy sounds of snoring caused by osa bother bed partner sleepless and lead to long-term health problems. most patients do not tolerate nasal continuous positive airway pressure device, which is the gold standard treatment of osa. press needle is one kind of acupuncture which possesses more safety and convenient, few complications and prolonged period of treatment time compared to conventional acupuncture. to date, there is no study to evaluate the effects of press needle in treating osa. the investigators hypothesize that press needle is effective with high acceptability among osa patients.

Eligibility criteria:
inclusion criteria: * willing to sign inform consent with aged more than 20 years old * mild to moderate osa, ahi \< 30 exclusion criteria: * severe osa, ahi \> 30 * significant lung disease * skeletal facial framework problems * central apnea * undergone oropharyngeal operations, continuous positive airway pressure or oral devices * taking hypnotic drugs * pregnancy or breast-feeding * receiving acupuncture in recent 2 weeks

Keywords: acupuncture press needle obstructive sleep apnea polysomnography
effects of a pulmonary and cardiovascular rehabilitation program

Conditions: Respiratory Muscle Weakness; Quality of Lifte; Dyspnea; Asthmatic; Dyspnea; Cardiac; Dyspnea

Summary: non-communicable chronic diseases (ncds) affect approximately 30% of the adult global population, significantly impacting respiratory function and quality of life. pulmonary and cardiovascular rehabilitation has proven to be an effective therapeutic intervention for managing respiratory symptoms and cardiovascular and improving functional capacity in patients with chronic respiratory conditions. the objective of this study is to evaluate the effects of the pulmonary and cardiovascular rehabilitation program on users of the physical therapy service of cecom of unicamp related to functional capacity, quality of life and respiratory variables after 3 months of the program. candidates for the pulmonary rehabilitation program are users diagnosed with chronic obstructive pulmonary disease (copd), pulmonary emphysema, pulmonary fibrosis, asthma or other lung disease. candidates for the cardiovascular rehabilitation program are users diagnosed with: infarction (ami), myocardial revascularization surgery, coronary angioplasty, stable angina, valve replacement, chronic heart failure and who meet the criteria for phase iii of cardiovascular rehabilitation. they should be referred to physical therapy by the cardiologist with complementary exams and exercise test. the program's assessment will consist of: anamnesis, analysis and recording of complementary exams, physical assessment (weight, height, bmi, cardiac and pulmonary auscultation, blood pressure, heart rate, peripheral oxygen saturation, respiratory muscle strength), functional capacity (six-minute walk test) and quality of life (questionnaire). the program will include aerobic exercises on a treadmill or stationary bike with an intensity between 50-70% of the reserve hr, below the ischemic thresholds. it will also include peripheral muscle strength exercises for the upper and lower limbs, in addition to respiratory muscle training for lung disease patients.


Eligibility criteria:
inclusion criteria: * candidates for the pulmonary rehabilitation program: users diagnosed with chronic obstructive pulmonary disease (copd), pulmonary emphysema, pulmonary fibrosis, asthma or other lung disease. * candidates for the cardiovascular rehabilitation program: users diagnosed with acute myocardial infarction, myocardial revascularization surgery, coronary angioplasty, stable angina, valve replacement, chronic heart failure and who meet the criteria for phase iii of cardiovascular rehabilitation. * referral with medical clearance for rehabilitation exclusion criteria: * patients with any contraindication to aerobic or muscle-strengthening physical exercise, such as significant arrhythmias, untreated heart disease, myocarditis, recent or untreated pulmonary embolism, and uncontrolled systemic arterial hypertension, among other conditions.

Keywords: pulmonary rehabilitation non-communicable chronic diseases cardiovascular disease cardiac rehabilitation
paclitaxel in treating patients with advanced head and neck cancer

Conditions: Head and Neck Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. purpose: phase ii trial to study the effectiveness of paclitaxel in treating patients with recurrent or metastatic head and neck cancer.

objectives: i. evaluate the response rate and toxic effects of paclitaxel by 96 hour continuous infusion in chemotherapy naive and chemotherapy exposed patients with recurrent or metastatic squamous cell carcinoma of the head and neck. outline: patients receive paclitaxel as a 96 hour continuous iv infusion. courses repeat every 3 weeks for a maximum of 12 courses. patients with disease progression after 2 courses or with unacceptable toxicity at any time are removed from study. projected accrual: approximately 109 patients will be accrued for this study over 4 years.

Eligibility criteria:
disease characteristics: histologically proven squamous cell carcinoma of the head and neck (including nasopharynx) that is considered incurable with surgery or radiation therapy bidimensionally measurable disease patients whose only site of measurable disease is within a previous radiation port must have documented progressive disease or biopsy-proven recurrence after the completion of radiotherapy no uncontrolled cns metastases patient characteristics: age: 18 and over performance status: ecog 0 or 1 hematopoietic: absolute neutrophil count at least 1,500/mm3 platelet count at least 100,000/mm3 hepatic: bilirubin no greater than 1.5 mg/dl renal: creatinine no greater than 1.5 mg/dl or creatinine clearance at least 60 ml/min calcium normal no history of hypercalcemia cardiovascular: no history of ventricular arrhythmias or symptomatic bradyarrhythmia other: no significant detectable infection not pregnant or nursing no other active malignancies fertile patients must use effective contraception prior concurrent therapy: biologic therapy: prior interleukin-2, interferons, and monoclonal antibodies allowed recovered from prior therapy chemotherapy: prior paclitaxel infusion no greater than 24 hours for recurrent or metastatic disease required endocrine therapy: not specified radiotherapy: recovered from prior radiotherapy surgery: recovered from any prior major surgery

Keywords: stage iv squamous cell carcinoma of the lip and oral cavity recurrent squamous cell carcinoma of the lip and oral cavity stage iv squamous cell carcinoma of the oropharynx recurrent squamous cell carcinoma of the oropharynx stage iv squamous cell carcinoma of the nasopharynx recurrent squamous cell carcinoma of the nasopharynx stage iv squamous cell carcinoma of the hypopharynx recurrent squamous cell carcinoma of the hypopharynx stage iv squamous cell carcinoma of the larynx recurrent squamous cell carcinoma of the larynx stage iv squamous cell carcinoma of the paranasal sinus and nasal cavity recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
family exergaming: a research study testing a videogame intervention to increase physical activity for families

Conditions: Obesity

Summary: the purpose of this study is to determine if an interactive game (dance dance revolution/ddr) can promote healthy physical activity for the health of all family members


Eligibility criteria:
inclusion criteria: * ages 9-17 * overweight status (bmi of 85% and above) * willing to come to two (2 hour) visits to mmcri for measurements and complete surveys * family participation exclusion criteria: * serious heart condition * photo-sensitive seizures * previous extensive history using ddr

Keywords: obesity exergames videogames prevention family dance dance revolution pedometer
evaluation of the effectiveness and safety of the ulthera® deepsee® system for treating skin laxity in the lower face and submentum

Conditions: Improvement in Skin Laxity of the Lower Face and Submentum

Summary: 1. demonstrate superiority of treatment with the ulthera deepsee system compared to untreated control for the improvement of skin laxity of the lower face and submental area. 2. demonstrate the safety of treatment with the ulthera deepsee system for the improvement of skin laxity of the lower face and submental area.

subjects in the study received a single treatment with ulthera deepsee system on the midface, lower face, submental (under the chin) and upper neck area using 3 deepsee (ds) transducers (ds 10-1.5, ds 7-3.0, ds 7-4.5) at either day 1 or day 90. subjects treated at day 1 were followed for 180 days after treatment and subjects treated at day 90 were followed for 90 days after treatment.

Eligibility criteria:
inclusion criteria: - mild to moderate lower face and/or submental laxity that is amenable to improvement with non-invasive intervention and is not severe enough for surgical intervention; exclusion criteria: * scarring in area(s) to be treated; * any active implants (e.g., pacemakers or defibrillators) in the area(s) to be treated; * any metallic implants in area(s) to be treated; * any open wounds or lesions in the area(s) to be treated; * body mass index (bmi) less than 19 or greater than 30; or * gain or loss of ≥ 2 bmi units within the previous 90 days or has the intention to gain or lose ≥ 2 bmi units during the course of the trial.
introduction of sophrology and art therapy in hand and upper limb surgery at lyon university hospital

Conditions: Hand and Upper Limb Trauma

Summary: the human and economic impact of hand and upper limb pathologies, whether acute or chronic, surgical or medical, is considerable on a national level. hand wounds and traumas account for 1/3 of work-related accidents and their consequences. the surgical procedure and its technical quality are essential, but so is the re-education and rehabilitation phase. it is in this post-operative context that sophrology and art therapy could have their place. literature in this precise field is non-existent. a study is therefore needed to determine the quality of life, feasibility and acceptability of these new techniques in the rehabilitation department of the édouard herriot hospital's hand and upper limb surgery unit. sophrology and art therapy could help to limit upper-limb sequelae by promoting confidence-building and functional participation, thus helping patients to return more quickly to an active life. given the current state of knowledge, the hypothesis being tested is that, within the framework of an existing multi-disciplinary team, art therapy and sophrology could improve quality of life and find favorable adherence on the part of patients usually cared for in the upper limb surgery department.


Eligibility criteria:
inclusion criteria: * adult (aged ≥ 18 years) * men and women * cared for in the hand and upper limb surgery department as part of emergency or scheduled activity or rehabilitation. * wishing to benefit from sophrology and/or art therapy in their care pathway. * having expressed his non-opposition exclusion criteria: * patients under legal protection * any patient who does not have a sufficient command of the language to enable comprehension and expression.

Keywords: hand and upper limb trauma sophrology art-therapy
treatment outcomes in patient with nontuberculous mycobacterial disease

Conditions: Nontuberculous Mycobacterial Disease; Atypical Mycobacterium Infections

Summary: little is known about the disease caused by the nontuberculous or environmental mycobacteria (ntm) and only limited data are available showing treatment outcome. this project will study the patients with nontuberculous mycobacterial (ntm) diseases in the university of illinois hospital \& health sciences system (uimc). the aim of study is finding treatment outcome and risk factors that are associated with treatment failure in ntm patients. this is a retrospective, observational study for collecting data on patients with ntm in uimc. the study initially involves populating the study of ntm patients seen at uimc during the study period. this will add our knowledge about current treatment outcome of patients with ntm diseases and will be of interest to physicians, and public health authorities.

the study focuses on collecting all mycobacterial data, clinical assessment and clinical outcomes of patients. data collection includes demographic characteristics, medical history, clinical procedures relative to the treatment of ntm, respiratory symptoms and signs, pulmonary function tests if applicable, imaging parameters, diagnostic tests, mycobacterial smear, culture, or possible susceptibility, therapies and outcome. the study will be updated with clinical outcomes (e.g., hospitalization, surgery relative ntm, and death) during study period. the data will be collected from 1/1/2001 to 12/30/ 2011. the confirmed ntm patient will be defined with ats guideline for ntm as: clinical: pulmonary symptoms, nodular or cavitary opacities on chest radiograph, or an hrct scan that shows multifocal bronchiectasis with multiple small nodules and 2. appropriate exclusion of other diagnoses. microbiologic: positive culture results from at least two separate expectorated sputum samples. (if the results from the initial sputum samples are nondiagnostic, we will consider repeat sputum afb smears and cultures.) or positive culture results from at least one bronchial wash or lavage. or transbronchial or other lung biopsy with mycobacterial histopathologic features (granulomatous inflammation or afb) and positive culture for ntm or biopsy showing mycobacterial histopathologic features (granulomatous inflammation or afb) and one or more sputum or bronchial washings that are culture positive for ntm. objectives 1. to determine prevalence of culture-confirmed ntm infection in the uimc in a ten- year period 2. to determine the prevalence of ntm disease based on ats case definition the uimc in a ten- year period 3. to determine treatment outcome of ntm disease in the uimc in a ten- year period 4. to find the risk factors associated with treatment failure of patients with ntm diseases

Eligibility criteria:
inclusion criteria: * aged 18 year or older with at least one culture-confirmed ntm. exclusion criteria: * all patients aged younger than 18 years old. * no individuals are excluded from study based on, race, ethnicity, gender, or hiv status.

Keywords: nontuberculous, atypical, mycobacterial
cnidium monnieri detoxification formula for persistent high-risk human papillomavirus infection of cervix.

Conditions: Human Papillomavirus (HPV) Infection; Cervical Cancer

Summary: the purpose of this study is to evaluate the clinical efficacy and safety of cnidium monnieri detoxification formula in clearing hpv infection, improving clinical symptoms and quality of life in female patients with persistent cervical high-risk hpv infection.

persistent infection with high-risk hpv is a major cause of cervical cancer and has negative psychosocial effects on women's health-related quality of life (qol). this prospective, single-arm, multicenter study is to evaluate the clinical efficacy and safety of cnidium monnieri detoxification formula in clearing hpv infection, improving clinical symptoms and quality of life in female patients with persistent cervical high-risk hpv infection.

Eligibility criteria:
inclusion criteria: * age ≥ 25 years to ≤ 75 years，with sexual life history * meet the diagnostic criteria for high-risk human papillomavirus (hr-hpv) persistent infection * after surgery or physical therapy for high-grade squamous intraepithelial lesions (hsil) of the cervix or high-grade squamous intraepithelial lesions (vainiii) of the vagina, or radical surgery for cervical/vaginal cancer or radical chemoradiotherapy, the examination remained positive for hr-hpv ≥6 months after the end of treatment, with the same type or multiple types as before treatment, and no progression or recurrence of the disease. * no local or systemic therapy has been administered to patients in the last 3 months * patients were informed of the study protocol, agreed to cooperate with the treatment, and signed informed consent. exclusion criteria: * only low-risk hpv infection * colposcopy for high-grade intraepithelial lesions or cancer of the cervix, vagina, vulva, who have not received or are receiving treatment * immunocompromised or immunosuppressant * pregnant and lactating women * patients with other malignant tumors not controlled, serious heart, lung, liver, renal insufficiency and coagulation dysfunction * people with communication or cognitive impairment * patients have contraindications to oral administration of traditional chinese medicine preparations * in the same period, other anti-hpv measures were used to treat, which affected the efficacy judgment

Keywords: human papillomavirus infection cervical cancer