Kornimate/medical-research-clean huggingface dataset:
efficacy of lcq908 on cardiovascular risk

Conditions: Coronary Artery Disease; Hypertriglyceridemia

Summary: this is a study designed to evaluate the potential for the pradigastat (lcq908) to impact cardiovascular risk.

this study had 2 parts. part a was a multicenter, double-blind, randomized, placebo-controlled, non-confirmatory crossover study assessing response to a high-fat meal challenge in the setting of pradigastat versus placebo. part a had 2 cohorts i.e. cohort 1 patients with stable coronary artery disease and hypertriglyceridemia and cohort 2 patients with asymptomatic non-obstructive coronary artery disease or elevated coronary heart disease risk and hypertriglyceridemia. part b was a double blinded phase designed to assess response to three months of chronic treatment with pradigastat versus placebo on a normal diet. the trial was terminated after the interim analysis of part a, cohort 1. the interim analysis results indicated that the high-fat meal challenge did not induce any impairment on either myocardial perfusion reserve index (mpri) or exercise treadmill performance. part b was never started.

Eligibility criteria:
inclusion criteria: * history of coronary artery disease * elevated triglycerides * on medication to help lower cholesterol exclusion criteria: * poorly controlled diabetic patients and/or change in diabetic medication within 12 weeks of screening * history of myocardial infarction (heart attack) within 6 months of screening * history of a procedure to open a blocked coronary artery within 12 months of enrollment * history of coronary artery bypass graft (cabg) surgery * history of congestive heart failure * history of significant heart valve disease

Keywords: coronary artery disease, lcq908, hyperlipidemia, hypertriglyceridemia, pradigastat
evaluation of familial mediterranean fever impact on oral and dental health in children and adolescents

Conditions: FMF

Summary: aim: it is the clinical and radiological evaluation of oral hygiene, teeth and surrounding tissues in children and adolescents diagnosed with fmf and comparing the results with healthy individuals. method: our study included patients aged 6-15, 45 with fmf (study group) and 45 healthy (control group), who were referred from akdeniz university faculty of medicine pediatric rheumatology clinic and evaluated at akdeniz university faculty of dentistry pedodontics clinic. mefv gene mutations were investigated in the study group. after recording the demographic and clinical characteristics of both groups, intraoral examinations were performed and dmft, dft, bruxism, tooth wear due to bruxism and gingival/plaque indexes were evaluated. saliva ph, flow rate and buffering capacity were measured. tooth age was determined by the cameriere method, the mesio-distal dimensions of the teeth were measured on the plaster model.

in the study, dmft, dft, bruxism, tooth wear due to bruxism, gingival index (mgi), plaque index (ohi-s), salivary ph, salivary flow rate, salivary buffering capacity, dental age, chronological age difference, mesio-distal dimensions of the teeth, and the presence of aphthous lesions were evaluated and compared between the study group consisting of children with fmf and the control group of healthy children.

Eligibility criteria:
inclusion criteria: * patients diagnosed with fmf, aged between 6-15 years, who were admitted/referred to the pediatric dentistry department clinic of akdeniz university faculty of dentistry for oral and dental examination, and who agreed to participate in the study after being thoroughly informed both verbally and in writing. * patients with no systemic diseases other than fmf. * patients who have not used any systemic antibiotics or similar medications (e.g., antidepressants, psychiatric drugs) within the last 3 months. exclusion criteria: * patients diagnosed with fmf, who were admitted/referred to the pediatric dentistry department clinic of akdeniz university faculty of dentistry for oral-dental examination but declined to participate in the study after being thoroughly informed both verbally and in writing. * patients with any systemic disease other than fmf. * patients who have used systemic antibiotics or any other medications (e.g., antidepressants, psychiatric drugs) within the last 3 months.

Keywords: fmf dmft saliva bruxism oral health
effects of capsaicin on the structure, distribution, and function of cutaneous small nerve fibers in psoriatic skin

Conditions: Psoriasis

Summary: the purpose of this research study is to examine the role of nerves in the skin in psoriasis and to better understand the effects of capsaicin in psoriasis.in this study, capsaicin will be compared to a moisturizer (aquaphor ointment).


Eligibility criteria:
inclusion criteria: * adult men and women who are 18 years of age or older. * diagnosis of plaque-type psoriasis is required to be confirmed by clinical criteria. * subjects must be in general good health with no other skin disease, disease state or physical condition which would impair evaluation of psoriasis or which would increase their health risk by study participation. * subjects must be willing to receive topical capsaicin weekly for 6 weeks and must be willing to undergo 3mm punch biopsies at baseline and at week 6. * subjects may not receive any systemic therapies during the study. * subjects are required to complete a 4 week washout period from any systemic medication and/or phototherapy prior to enrolling in the study. * stable use of moisturizers will be allowed provided that use has been stable for at least 14 days. * women of child bearing age will be required to have a negative pregnancy test in order to enroll in the study and will be required to maintain adequate birth control throughout the study. exclusion criteria: * subjects who are unable to complete the required measures. * subjects diagnosed with other skin diseases that would affect the measurement of cutaneous blood flow. * subjects with any history of any disease associated with neuropathy, including diabetes, alcoholism, uremia, hiv infection, hypothyroidism, or cancer chemotherapy. * subjects who are currently enrolled in any investigational study in which the subject is receiving any type of drug, biologic, or non-drug therapy and subjects undergoing treatment with another investigational drug or approved therapy for investigational use within 28 days prior to investigational drug administration. * subjects who have used any topical therapy for psoriasis or other skin diseases in the past 7 days. * subjects receiving any of the following treatments or agents within the 28 days prior to investigational drug administration will be excluded: systemic retinoids, systemic steroids, methotrexate, cyclosporine, azathioprine, thioguanine, etanercept, efalizumab, infliximab, adalimumab or mofetil or other systemic immunosuppressant, and phototherapy, including ultraviolet b (uvb) and psoralen + ultraviolet a (puva). * subjects with a known allergy to capsaicin. * children less than 18 years of age. * pregnant women.
conservation of praxis in the food and alzheimer disease

Conditions: Alzheimer Disease

Summary: the insanities, priority of public health in 2008, have significant prevalency in limousin, region in the ageing demography (1/3 of the population is more than 60 years old against 1/5th of average in france). to prevent the lack of therapeutic solutions, for these evolutionary diseases, the new plan alzheimer 2008-2012 encourages the research. the insanities deprive gradually the individual of their autonomy, their personality and their identity. the help of an institution is sometimes inevitable. in the middle of this stressful environment, the patient affected by severe insanity, need marks. the aspect of their old objects, significant for them, has to be prioritized because the institutional universe, often depersonalized doesn't mean anything for them. in front of repeated failures, they're hurt in their self respect. the prevention of the undernutrition, comes by a preservation of praxis and pleasure at table. the institutional plate used in certain hospital sectors, is unpersonal (rectangular, divided) and can be destabilizing for the mentally ill person.


Eligibility criteria:
inclusion criteria: * men and women of more than 75 years * patients suffering from insanities of type alzheimer * severe stage of the disease * residents in a hospital for dependent old persons, with its own dining room * persons accommodated in the clinical service for more than 30 days * ebs score \<16 * information in the participation of the resident, their legal representative and their family * patients affiliated to the social security. * filled and signed form of participation * patient having a appointed reliable person or one helping known whose references are indicated in the patient file. exclusion criteria: * patients presenting pathologies being able to interfere with the evaluation * participating patients in another research for type clinical trial. * undernutrition patients * patients presenting oral hurts * protected patient or having nobody helping.
chinese medicine therapy on menopausal symptoms

Conditions: Menopause

Summary: the objective of this study is to evaluate whether a chinese medicine formula (erxian decoction，exd) is effective in alleviating menopausal symptoms, improving sex hormone profile and bone turn-over.

this is a double-blind randomized placebo-controlled clinical trial to evaluate whether a chinese medicine formula (erxian decoction) is effective in alleviating menopausal symptoms. this study will be conducted in queen mary hospital and chinese medicine clinic cum training and research centers of the university of hong kong (sassoon road and central). women will be recruited from the general population by advertisements and promotion through media coverage.108 chinese women with menopausal symptoms will be recruited and randomized into two groups.one is treatment group with 12 weeks of erxian decoction (well-controlled granules), the other is controlled group with 12 weeks of placebo. the treatment outcome measures include: 1) the severity of menopausal symptoms: self-recording of daily frequency of vasomotor symptoms (hot flushes plus night sweats),the menopause-specific quality of life (menqol) questionnaire and the menopause rating scale(mrs). 2)biochemical indices:serum follicle-stimulating hormone(fsh),luteinizing hormone(lh),estradiol, progesterone levels. 3)safety indices: blood count,liver and renal function tests. all measures are conducted at baseline and endpoint except the self-recoding of vasomotor symptoms and menqol questionnaire, mrs. we expect this research will provide an effective and low-cost therapy for menopausal symptoms.

Eligibility criteria:
inclusion criteria: 1. chinese women aged 45 to 55 years old 2. having irregular menstrual cycles (≥3 months) indicating perimenopausal status or with cessation of menstrual period for at least three months within the previous 12 months 3. total scores of menopause rating scale≥28 indicating the menopausal symptoms are moderate or severe 4. not having used hrt or chinese medicine for at least 3 months prior to entry into the study 5. willing to give informed ,written consent to participate in the clinical study exclusion criteria: 1. taking hormones or medications, which could affect the vasomotoric symptoms 2. having chronic illness, such as gastrointestinal, renal or liver disease, diabetes mellitus requiring treatment, uncontrolled hypertension 3. having serious diseases, such as cancer, autoimmune system diseases, thrombosis and thrombophlebitis 4. consuming alcohol, or taking psychiatric or psychotherapeutic drugs

Keywords: hot flushes night sweats menopausal symptoms osteoporosis complementary and alternative medicine
effect of proprioceptive exercises on pain and function in non-specific chronic neck pain

Conditions: Neck Pain

Summary: this study was conducted to see the effect of proprioceptive exercises on pain and function in non-specific chronic neck pain. twenty participants with chronic non-specific neck pain were enrolled in this study. during the final week of treatment, 14 patients were assessed at the end of the sixth treatment week. participants were randomized into two groups treatment group and control group. both groups were treated with conventional treatment which were strengthening exercises. treatment group was also treated by proprioception exercises. for measurement of pain and disability nprs and ndi scales were used. exercise regime distributed in six weeks period one session per week exercise, 10-12 repetitions with 1-minute rest interval, lasted 45 minutes in both groups. pre-treatment and post-treatment measurements were taken.


Eligibility criteria:
inclusion criteria: * patients with non-specific neck pain\>3 months * postural neck pain exclusion criteria: * vascular neoplasia * fibromyalgia * rheumatoid arthritis * radiculopathy * neuropathy * tumor * cervical fractures * vestibular problems * congenital disorder of cervical spine

Keywords: neck disability index, numerical pain rating scale proprioceptive exercise
decrease of recurrent pancreatitis

Conditions: Pancreatitis

Summary: retrospective studies have shown, that about half of the patients will have a recurrent episode after the first acute alcoholic pancreatitis. of the patients in hospital, more than half annually are treated for recurrent acute pancreatitis. because alcohol has been shown an important factor in the development of recurrent pancreatitis, it was hypothesized, that by attempting intensively to diminish the individual alcohol consumption the number of recurrent pancreatitis could be decreased. two protocols will be compared: a) initial intervention against alcohol abuse and b) repeated interventions at 6 month intervals.


Eligibility criteria:
inclusion criteria: * patients who recovered from their first acute alcoholic pancreatitis and start to be ready to be discharged from hospital exclusion criteria: * other etiologies of pancreatitis besides alcohol * uncertain diagnosis * recurrent disease * refusal

Keywords: pancreatitis acute alcoholic recurrence alcoholism treatment acute alcoholic pancreatitis
diagnostic of lower respiratory tract infection by lung ultrasonography in general practice

Conditions: Lower Resp Tract Infection; Ultrasound Therapy; Complications

Summary: lower respiratory tract infection (lrti) is a frequent motive of consultation in general practice. cost, irradiation and availability of traditional imagery make it difficult to perform in every patient with suspected lrti. the objective is to evaluate the performance of lus realized by family physicians into the usual lrti diagnostic pathway. this study is a prospective, interventional, multi-centric and open study conducted in 3 different centers by 15 general practitioners (gp) in france. patient complaining of dyspnea or cough were recruited from december 2019 to march 2020. gp received a training course by lus expert before the study. the primary outcome measure was diagnosis modification after lus. secondary measures were therapeutic modification after lus, decision of imagery prescription after lus, decision of hospitalization or not after lus, medical evolution and result of imagery initially prescribed by gp.

after an initial medical report, gp's concluded to an initial diagnosis and make initial prescription and finally decided or not to perform a standardized eight-points lus. gp were free to perform or not lus. if gp decided to perform lus, gp were allowed to change their diagnosis and prescriptions (lus group). however, therapeutic changes after lus could not "downgrade" patient care.

Eligibility criteria:
inclusion criteria: * age \> 3 months * dyspnea or cough complaint exclusion criteria: * age \< 3 months * rejection to participate to the study

Keywords: lung ultrasonography lower respiratory tract infection general practice
cabp2 patient registry and natural history study

Conditions: CABP2-related Auditory Synaptopathy; Hearing Impairment

Summary: this registry is designed to collect comprehensive information about the molecular genetic diagnoses and clinical information of individuals with cabp2-associated hearing impairment to support a natural history study.

a patient registry, in both german and english languages, has been established for patients with hereditary hearing impairment due to variants in cabp2. the study is conducted in accordance with the current version of the declaration of helsinki. the study protocol and database structure have been approved by the ethics committee of the university medical center goettingen.

Eligibility criteria:
inclusion criteria: * a molecular genetic diagnosis involving biallelic variants in capb2 and audiometry exclusion criteria: * patients with evidence of non-cabp2 molecular genetic diagnoses

Keywords: cabp2 patient registry patient registry dfnb93
the prevalence of erectile dysfunction (ed) and ed related quality of life of diabetic men

Conditions: Diabetes; Erectile Dysfunction

Summary: adult diabetic patients aged above 20 attending the diabetic clinic of national taiwan university hospital are invited to attend a face to face screening and interview. after obtaining the informed consent, questionnaires including iief, dan-pss-sex and erectile dysfunction effect on quality of lie are filled.personal data, status of diabetes control and complications of diabetes are recorded.the results will be used to investigate the prevalence of erectile dysfunction of diabetic men in taiwan and erectile dysfunction related quality of life change.

adult diabetic patients aged above 20 attending the diabetic clinic of national taiwan university hospital are invited to attend a face to face screening and interview. after obtaining the informed consent, questionnaires including iief, dan-pss-sex and erectile dysfunction effect on quality of lie are filled.personal data, status of diabetes control and complications of diabetes are recorded.the results will be used to investigate the prevalence of erectile dysfunction of diabetic men in taiwan and erectile dysfunction related quality of life change.

Eligibility criteria:
inclusion criteria: diabetic male age above 20 exclusion criteria: men using any form of erectile dysfunction treatment-

Keywords: diabetes erectile dysfunction erectile dysfunction related quality of life
technology-based prevention for adolescents in primary care

Conditions: Substance Use

Summary: adolescent substance use, sexual assault, and sexual risk behaviors pose a great public health concern, and subsequently there is also a great need to prevent these behaviors and experiences. this project involves the adaptation and integration of evidence-based prevention content aimed at preventing and reducing substance use, sexual assault, and sexual risk behaviors. this project uses innovative technology within primary care visits to conduct a feasibility trial of an integrated prevention program.

pilot feasibility trial in preparation for rct. adolescents aged 14-18 will be recruited for screening from community-based primary care clinics to ensure ease of dissemination and representation of community-based primary care settings. the primary goal is to develop feasibility to apply for an r01 to conduct an rct. power analyses indicate that 280 participants would be needed for an rct after accounting for attrition. given that the rct would be conducted over a 3-year period, a recruitment rate of 8 adolescents per month would indicate feasibility for a larger rct.

Eligibility criteria:
inclusion criteria: * aged 14-18 * recent visit to primary care doctor exclusion criteria: * inability to comprehend english independently due to disability or language

Keywords: adolescents primary care sexual assault substance use sexual risk behavior
haplo hct vs haplo-cord hct for patients with aml

Conditions: Hematopoietic Stem Cell Transplantation; Haplo-identical Donor; Cord Blood Unit; Acute Myeloid Leukemia

Summary: patients who have acute myeloid leukemia and will undergo haplo-identical donor hematopoeitic cell transplantation (haplo hct) are potential candidates of this trial. participants will randomized into two arms: arm a will undergo a typical haplo hct, while arm b will receive an coinfusion of an unrelated cord blood unit (haplo-cord hct) in addition to arm a. progression-free survival, overall survival, cumulative incidence of relapse and nonrelapse mortality will be recorded as endpoints.


Eligibility criteria:
inclusion criteria: 1. age 18 to 60 years old; 2. patients with aml; 3. with available minimal residual disease (mrd) parameters assessed by flow cytometry (fcm) and/or quantitative real-time pcr (qpcr) 4. having no available hla-matched donor, and willing to undergo haplo-hct and having a suitable haploidentical donor 5. with eastern cooperative oncology group (ecog) performance status of 0-3 6. signing informed consent form, having the ability to comply with study and follow-up procedures exclusion criteria: 1. acute promyelocytic leukaemia (aml subtype m3) 2. with other malignances 3. failing to acquire a suitable ucb unit 4. with previous history of autologous haematopoietic cell transplantation (auto-hct), allogeneic haematopoietic cell transplantation (allo-hct) or chimaeric antigen receptor t-cell therapy 5. with uncontrolled infection intolerant to haplo-hct 6. with severe organ dysfunction * cardiac dysfunction (particularly congestive heart failure, unstable coronary artery disease and serious cardiac ventricular arrhythmias requiring antiarrhythmic therapy) * respiratory failure (pao2≤60 mmhg) * hepatic abnormalities (total bilirubin≥2×upper limit of normal \[uln\], alanine aminotransferase or aspartate aminotransferase≥2×uln) * renal dysfunction (creatinine≥2 mg/dl creatinine clearance rate \< 30 ml/min) 7. in pregnancy or lactation period 8. with any conditions not suitable for the trial (investigators' decision)
a phase 1 study investigating the combination of rad001, cetuximab and irinotecan as second-line therapy after folfox (or xelox) plus bevacizumab in patients with metastatic colorectal cancer

Conditions: Colorectal Cancer; Colorectal Carcinoma; Colorectal Tumors; Neoplasms, Colorectal

Summary: this study will assess the safety of rad001 when given together with cetuximab and irinotecan


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old and ≤ 65 years old. * patients with metastatic crc. confirmation of crc diagnosis by histological or cytological specimen from original resection of primary tumor. * patients who progressed despite prior therapy with folfox (5fu and oxaliplatin) plus bevacizumab or xelox (capecitabine and oxaliplatin) plus bevacizumab. * patients with at least one measurable lesion by recist as determined by computer tomography (ct) scan, magnetic resonance imaging (mri) or physical examination. * patients with a who performance status of 0 or 1. exclusion criteria: * patients with gilbert's syndrome or any other syndrome associated with deficient glucoronidation of bilirubin. * patients who are homozygous for the ugt1a1\*28 allele as determined by sequencing. * patients who have received previous irinotecan-based therapy. * prior treatment with an mtor inhibitor. other protocol-defined inclusion/exclusion criteria may apply

Keywords: colorectal cancer colorectal carcinoma colorectal tumors neoplasms, colorectal