Kornimate/medical-research-clean huggingface dataset:
severity score for covid-19 pneumonia

Conditions: COVID; Pneumonia

Summary: the outbreak of the coronavirus disease 2019 (covid-19), first merged in china in december 2019, is now becoming a public health emergency, recently confirmed as a pandemic disease by the world health organization. in particular, since february 2020, a rapidly growing number of cases has been identified in italy. the clinical picture of ranges from asymptomatic cases, mild upper respiratory tract infections to severe pneumonia with respiratory failure and death. in most severe cases, covid-19 disease may be complicated by acute respiratory distress syndrome (ards), septic shock and multiorgan failure. it results fundamental to early identify those subjects who rapidly may worsen their clinical status, often requiring an intensive care unit (icu) admission. it has been showed that, mainly in more severe forms of sars-cov-2 disease, there is the development of an hyperinflammatory status resembling a cytokine storm syndrome, as already reported in sars patients. a recent study by haung et al. reported that patients with covid-19 infection showed high amounts of il1b, ifn-gamma, ip10 and mcp1, probably linked to activated t-helper1 (th1) cell responses. those requiring icu admission had higher levels of cytokines than those subjects not requiring icu admission, thus suggesting that cytokine storm was associated with disease severity. a similarity between cytokine profile of covid-19 disease and secondary haemophagocytic syndrome (shlh) has been reported. therefore, it was suggested to screen all patients with severe covid-19 infection both for hyperinflammatory markers (like ferritin), and the hscore commonly used to generate a probability for diagnosis of shlh (8), which includes some laboratory parameters like triglycerides, fibrinogen, ferritin, serum aspartate aminostransferase. based on our experience on patients affected by pneumonia from covid19, we have observed that those subjects with a more severe prognosis might have some predictive markers. we intend to verify if these markers can identify those subjects with covid19 infection who need a more intensive therapy and to find a prognosis score.


Eligibility criteria:
inclusion criteria: patients with diagnosis of pneumonia, confirmed by chest imaging, covid-19 test positive exclusion criteria: age lower than 18 years, pregnancy or breast-feeding
randomized study comparing pleural drainage by videothoracoscopy to medical drainage in infectious pleural effusion

Conditions: Infectious Pleural Effusion

Summary: infectious pleural effusion is a classic complication of pneumonia and often require pleural drainage. there is no consensus between surgical drainage and medical drainage indication in first intention to treat an empyema. usually surgery is proposed in second intention after failure of medical drainage. videothoracoscopy is well accepted in diagnosis and treatment of pleural pathologies. the morbidity of this approach is very low with good results and become the gold standard in different pleural diseases. the medical drainage can be also very efficient but its results depends of the evolution of the pleural effusion. the rate of failure is estimated around 25%. then, the aim of our study is to compare surgical drainage and medical drainage in first intention. the first end-point will be the hospital stay (day). hospital discharge will be strict, following different objective criteria of healing allowing comparison between these two approaches of drainage. to answer this question we will randomized 50 patients in 2 years with a multicenter recruitment.


Eligibility criteria:
inclusion criteria: * infectious pleural effusion diagnosed by pleural punction with biologic features of infection: c reactive protein level \>5 mg/l, white cells counts \> 10000 g/l, temperature \>38°c, effusion with a ph\ 1/5 thoracic volume) exclusion criteria: * prior thoracic surgery, past history of pleural effusion * compressive effusion which should be treated in emergency * pregnancy * no acceptance of the protocol by the informed patient
focus on analysis of recovery in oximetry

Conditions: Intermittent Claudication

Summary: analysis of localizations for symptoms and ischemia on treadmill and of the recovery profiles of patients that have had an exercise oximetry

patients referred for exercise oximetry have buttocks thighs and calves recording during exercise and in the recovery period for a minimum of 10 minutes. for each limb probe the decrease from rest of oxygen pressure (drop) index is calculated as a subtraction of chest changes from limb changes throughout rest, exercise and recovery. drop was measured as a routine on buttocks, thighs and calves and a minimal drop lower than minus 15 mmhg considered indicative of the presence of regional blood flow impairment (ischemia) in the considered area. recordings and patients characteristics are recorded on a institutionally validated database. a comparison will be performed of symptoms by history to symptoms reported on treadmill and hemodynamic results attained through drop values. re-analysis of the recordings after ethical approval will be performed in an aim at estimating the duration of 50% and 90% recovery of drop at the different levels (buttocks tigh and calves) to account for hemodynamic impairmenty not only at the calf (calves) level.

Eligibility criteria:
inclusion criteria: * available exercise oximetry recording exclusion criteria: * deny of the use of the medical file from the patient
non invasive ventilation and weaning : venise trial

Conditions: Weaning; Chronic Respiratory Failure

Summary: the clinical efficacy of noninvasive ventilation (niv) has now been demonstrated in the management of acute-on-chronic respiratory failure (acrf) of various etiologies. endotracheal mechanical ventilation (etmv) can lead to numerous complications and weaning difficulties increasing the risk of prolonged etmv, morbidity and mortality as well as excess cost of intensive care. therefore, it could be interesting to use niv for delivering effective ventilatory support and reduce the length of etmv in acrf patients still not capable to maintain spontaneous breathing. from the interesting but discordant results of two recent randomised controlled trial, a working group from the société de réanimation de langue française (srlf) decided to perform a new prospective randomised controlled and multicenter trial. the aim of the study is to assess the usefulness of niv as an extubation and weaning technique in ventilated acrf patients. the methodology used compares three weaning strategies in parallel in acrf patients considered difficult to wean : invasive conventional weaning (group a), extubation relayed by nasal oxygentherapy (group b), and extubation relayed by niv (group c). based on the main end-point defined as the weaning success/failure rate, 208 patients from17 investigator centers are planned to be included. results of the study will also allow to assess the respective impact of the three weaning strategies on the length of etmv and weaning, the mechanical ventilation-related morbidity, the patients lengths of stay and mortality. results of the venise trial should permit to improve the management of the difficult to wean acrf patients and thus to contribute to more define the place of niv among the weaning and prevention of re-intubation strategies in these patients.


Eligibility criteria:
inclusion criteria: * endotracheal mechanical ventilation for 48 hours or more for acute respiratory failure in chronic respiratory failure patients (obstructive or restrictive disease), * patient ready to be weaned (steady respiratory and hemodynamic conditions for 24 hours), * spontaneous breathing trial failure occurring between 5 minutes and 2 hours, judged on clinical and/or arterial blood gas tolerance, * written informed consent obtained (patient or family) exclusion criteria: * respiratory and hemodynamic instability * initial intubation considered as difficult * swallowing disorders suspected * inefficient cough * bronchial hypersecretion at the weaning time * non cooperant patient * contra-indications for nasal or facial mask (facial skin lesions,...) * recent history of upper gastro-intestinal surgery * recent history of myocardial infarction

Keywords: mechanical ventilation weaning noninvasive ventilation acute on chronic respiratory failure
study to evaluate the efficacy and safety of pac-14028 cream in rosacea patients

Conditions: Erythematotelangiectatic Rosacea; Papulopustular Rosacea

Summary: the objective of this study is to determine the efficacy and safety of pac-14028 1% cream of amorepacific corporation in patients with erythema-telangiectatic or papulopustular rosacea


Eligibility criteria:
inclusion criteria: * male and female patients at the age of 20 to 65 years old * clinical diagnosis of erythematotelangiectatic or papulopustular rosacea according to national rosacea committee expert society with * erythema severity ≥ 1 * telangiectasia severity ≥ 1 * at least 3 papules or pustules in facial region * iga score ≥ 2 * voluntarily signed written informed consent forms for study participation exclusion criteria: * patients who are unable to be diagnosed or evaluated for rosacea due to tattoo or scar in the facial area * patients who are unable to be diagnosed or evaluated for rosacea due to excess hair(e.g., mustache, beard, whiskers etc.) in the facial area * patients who are sensitive to the drug or vehicle * previous administration of oral retinoid or vitamin a(≥10,000 units/day) within 6 months prior to visit 1 * previous use of estrogen or oral contraceptives within 3 months prior to visit 1 * previous use of topical retinoids or oral antibiotics (e.g., tetracycline, tetracycline derivatives, erythromycin, erythromycin derivatives, sulfamethoxazole, trimethoprim) or oral steroid for the treatment of facial rosacea within 1 month prior to visit 1 * previous use of topical steroid or topical antibiotics, topical treatment for rosacea(e.g., metronidazole, azelaic acid) within 2 weeks prior to visit 1 * presently undergoing anti-coagulant therapies * history of hematologic disease * ocular-only, phymatous rosacea, or papulopustular rosacea patients who require systemic antibiotics * history of laser treatment for rosacea within 6 weeks prior to visit 1 * alcoholic or drug abuse patients * patients who are treated with prohibited concomitant drugs or considered to inevitably require treatment with prohibited concomitant drugs during the study period * renal function impairment with creatinine level higher than twice of maximum normal range * hepatic function impairment with ast/alt higher than twice of maximum normal range * pregnant and lactating woman, woman with child-birth potential(should have negative pregnancy test at the baseline visit of the study) * participation in another clinical study within 1 month prior to screening * patients considered ineligible for study participation by the principal investigator or sub-investigator for other reasons; rosacea due to other medical (liver disease, renal failure, etc.), psychotic, or neuropathic causes rather than as a skin disease
comparison of tlh and lavh with over than 500g

Conditions: Hysterectomy, Benign Uterine Diseases

Summary: since the introduction of total laparoscopic hysterectomy in 1989, laparoscopic gynecologic surgery has undergone many advances. tlh or lavh has the advantages of faster recovery, fewer complications and shorter hospitalization compared to total abdominal hysterectomy. however, the hysterectomy for giant uterus has the difficulty of delivering the uterus out of the body. according to the results of tlh, lavh and abdominal hysterectomy, tlh and lavh show the postoperative complications were less frequent (3) and the postoperative recovery (4) and return to daily life were faster than total abdominal hysterectomy (3) even if it took longer operation time. therefore, laparoscopic hysterectomy has many advantages over abdominal hysterectomy and indications are increasing. however, there has not yet been a direct comparison between tlh and valh for large uterine surgery. in this study, we compared the results including the complications, hospitalization period and so on., in undergoing operation and post-operation between tlh and lavh for the removal of giant uterus, which is predicted to be over 500 g.


Eligibility criteria:
inclusion criteria: * have the indication for hysterectomy for a supposed benign uterine disease * have a giant uterus of 500g or more * estimation of uterine weight more than 500g * uterine myoma size at 4 months or more after pregnancy due to pelvic examination * the length of the long axis of one uterine myoma is more than 8cm or the length of the long axis for over 2 uterine myomas is more than 6cm * have been not pregnant at the time of presentation * have been appropriated medical status for laparoscopic surgery (surgery (american society of anesthesiologists physical status classification 1 or 2) exclusion criteria: * have a suspicion of malignancy or malignant tumors (cervical cancer, ovarian cancer, fallopian tube cancer, peritoneal cancer, endometrial cancer)
effect of specific acl injury prevention training in female handball players

Conditions: ACL Injury Prevention

Summary: the anterior cruciate ligament (acl) injuries rates in female handball are high, particularly among adolescents. therefore, the primary purpose of this randomized control trial is to explore the effects of an 8-week acl injury prevention program on muscle activation of the medial hamstring muscles during sidecutting in female handball players. secondary aims are to evaluate if training effects are age-related (pre-adolescent: 11-13 year old vs. adults: ≥18 years old). the age-related comparisons include: 1. medial hamstring muscles activation during sidecutting; 2. well-known biomechanical acl injury-risk factors during high risk movements, such as cutting and landing tasks; 3. cortical and muscular activity and functional connectivity patterns during controlled knee movements; 4. visuomotor skill learning during a simple task involving the hamstring muscles.


Eligibility criteria:
inclusion criteria: * female handball players playing in youth teams from the age group under 13 (11-13 years old) and adult (≥18 - 40 years old) females playing for elite u19 or senior teams in denmark * have minimum 1 year of experience from playing handball * mental and physical skills to complete the electrophysiological and biomechanical tests exclusion criteria: * girls/women outside the age groups listed above * prior surgeries to the lower limbs (e.g. acl-reconstructions, meniscus lesions) * current intake of medications that include antidepressants, anxiolytics, anticonvulsants, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines * neurological and/or psychiatric diagnoses * pregnant

Keywords: acl injuries age-related neuromuscular motor-learning
evaluation of immunoassay measurements of pancreatic stone protein performed on abioscope® device with the psp assay on icu patients at risk of sepsis as an aid in identifying sepsis

Conditions: Sepsis

Summary: this is a multicenter, prospective, biomarker-result-blinded observational study evaluating immunoassay measurements of pancreatic stone protein (psp) performed on abionic's abioscope device with the psp assay on icu patients at risk of sepsis as an aid in identifying sepsis.


Eligibility criteria:
inclusion criteria: * 1. provision and understanding of signed and dated written informed consent by patient or legally designated representative prior to any mandatory study-specific procedures, sample collection, or analysis. * 2. male or female, aged ≥ 18 years. * 3. admitted to icu on the day of screening, with expectation that patient will require icu management for a minimum of 24 hours. exclusion criteria: * 1. expected to die within 24 hours no matter what therapy is given, from the time of screening. * 2. suffering on icu admission or study entry from or known acute or chronic pancreatitis or pancreatic cancer). * 3. admitted to icu due to elective cardiac surgery with an uncomplicated stay anticipated. * 4. patients having a valid do not resuscitate order. * 5. previous icu admission during this hospital stay * 6. confirmed covid-19 as reason for icu admission

Keywords: sepsis pancreatic stone protein point-of-care device immunoassay intensive care unit abionic
cytoreductive surgery in platinum-resistant recurrent ovarian cancer

Conditions: Cytoreductive Surgery

Summary: this novel study was specifically designed for platinum-resistant recurrent ovarian cancers with pfi\<6 months and aimed to compare prognosis of patients who received cytoreductive surgery followed by chemotherapy versus chemotherapy alone.


Eligibility criteria:
inclusion criteria: 1. patients with diagnosis of epithelial ovarian carcinoma, peritoneal carcinoma, or fallopian tube carcinoma within 3 lines recurrence; 2. recurrence occurred within 6 months since platinum-based chemotherapy; 3. r0 ideal debulking in initial surgery; pet-ct indicate the recurrence lesion is almost in abdominal cavity, which is isolated and not exceed 5 sites, and the ascites is less than 500ml; 4. ecog/who performance score of 0 to 1; 5. hematology function: leukocyte≥ 3,5x10⁹/l, neutrophil≥ 1,5x10⁹/l, platelets ≥ 100x10⁹/l; 6. no renal insufficiency: serum creatinine \ 60 ml/min; 7. no hepatic failure: bilirubin ≤ 1,5 time the normal limit; 8. patients with good compliance; 9. patients having read, signed and dated informed consent before any study procedure. exclusion criteria: 1. platinum-refractory/uncontrolled epithelial ovarian cancer; 2. mucous carcinoma or low-grade serous carcinoma; 3. suffering from other malignant tumors that have not achieved complete remission in the past 2 years; 4. patients have received abdominal or pelvic radiotherapy; 5. general conditions cannot tolerate cytoreduction; 6. severe hypersensitivity reactions (≥ grade 3) to paclitaxel or platinum and/or any of its excipients; 7. unable or unwilling to sign the informed consent form; 8. patients judged by the investigator to be unlikely to follow the research steps, restrictions and requirements.
room air a safe alternative to dye injection in ureterography

Conditions: Ureteral Obstruction

Summary: the procedure began in the thirties .retrograde pyelography is an essential step in most endoscopic procedure. this procedure is used as an investigation, with different indication in the past and the present, to delineate the ureter and pelvicalyceal system either before or after the operation, for example to detect any complication as a perforation and the need for stent placement. the procedure has an alternative, less invasive, the ivp. multiple articles explored the use of air in the puncture of pcnl and to identify the posterior calyx, but to our knowledge there is no articles addressed the idea of air injection in the ureter. the greatest fear is air embolism or non-visualization of the ureter. the availability and cost of contrast material may be a problem, most urologist face

our aim is to explore the feasibility of using room air as a contrast material and check the safety of this procedure. materials and methods: a pilot study in assiut university hospital urology department to evaluate the efficacy of air injection as a replacement dye injection in cases of endoscopy either in emergency or elective situation. twenty patients were selected randomly, to evaluate the impact of retrograde pyelography (rpg) using air in cases of obstructed ureters and raised renal function.

Eligibility criteria:
inclusion criteria: * all patients undergoing urs exclusion criteria: * no
nabilone versus amitriptyline in improving quality of sleep in patients with fibromyalgia

Conditions: Fibromyalgia; Sleep Initiation and Maintenance Disorders

Summary: most chronic pain patients with insomnia are currently not well-managed using existing medications. if found to safely improve sleep with chronic pain patients, nabilone could be added to the treatment options available in the management of fibromyalgia and associated symptoms. the principle hypothesis of this study is that nabilone at a dose of 0.5-1mg is as efficacious as amitriptyline at a dose of 10-20mg, in improving sleep quality in patients with fibromyalgia.


Eligibility criteria:
inclusion criteria: * patients aged ≥18 years; * a diagnosis of fibromyalgia according to the american college of rheumatology classification criteria (wolfe f, smythe ha, et al 1990); * suffering from self-reported disturbed sleep; * negative urine screen for cannabinoids; * women of childbearing potential must agree to use adequate contraception during study and for 3 months after study; * ability to attend research centre every second week for approximately seven to nine weeks and be able to be contacted by telephone during the study period; * stable drug regimen for 1 month prior to randomization; * normal liver (ast \<3x normal) and renal function (serum creatinine \<133µmol/l); * haematocrit \>38%; * negative serum bhcg; * proficient in english or french; * willing and able to give written informed consent; * ability to follow study protocol (cognitive and situational). exclusion criteria: * patients currently using cannabis or cannabinoid or tricyclic antidepressants (tca) and who are unable to undergo a 2 week washout period before entering the study; * pain due to cancer; * unstable cardiac disease such as cardiac arrhythmias, cardiac failure, ischaemic heart disease and/or hypertension on clinical history and examination; * history of psychotic disorder or schizophrenia; * known hypersensitivity to cannabinoids, amitriptyline, or related tricyclic antidepressants; * currently taking or unable to stop taking monoamine oxidase inhibitors (a two-week washout period is necessary for subjects taking maois); * history of seizures/epilepsy; * diagnosis of glaucoma; * urinary retention; * pregnancy and/or breast-feeding; * participation in other clinical trial in the 30 days prior to randomization; * a recent manic episode (within the past year); * current suicidal ideation or history of suicide attempts

Keywords: fibromyalgia cannabinoid chronic pain sleep insomnia diffuse widespread pain antidepressant
a real-world study on extranodal lymphoma

Conditions: Lymphoma; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Extranodal Lymphoma; Diffuse Large B Cell Lymphoma

Summary: the aim of this study is to prospectively collect clinical information on patients with extranodal lymphoma, and to explore the best therapeutic strategies in the real-world population.

lymphoma is a common hematological malignancy. many different pathologic types of lymphoma can originate in extranodal organs or be associated with extranodal organ involvement. for lymphoma with extranodal involvement, conventional regimens often cannot provide satisfactory results for patients. this study aims to prospectively collect clinical information on patients with extranodal dlbcl, including the distribution of involved sites, clinical and molecular characteristics of different lymphoma subtypes, clinical treatment protocols, and prognosis, to explore the the best therapeutic strategies in the real-world population.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years (including 18 years old). 2. patients newly diagnosed with non-hodgkin lymphoma with extranodal involvement, whether it is primary, secondary, or cannot be determined. 3. patients who have received systematic clinical treatment. 4. patients with measurable lesions, at least containing one effective evaluation of efficacy. exclusion criteria: 1. patients who only receive supportive treatment. 2. patients who cannot obtain effective evaluation data of efficacy.

Keywords: lymphoma extranodal dlbcl