Kornimate/medical-research-clean huggingface dataset:
brain mri longitudinal volumetric characteristics associated with outcomes of caspr2-limbic encephalitis

Conditions: Autoimmune Encephalitis Associated With Anti-CAPR2 Antibodies

Summary: anti-caspr2 limbic encephalitis (caspr2-le) is a rare neurological disorder primarily affecting males over the age of 50. it is mediated by an autoimmune antibody response in the central nervous system (cns) against the cellular adhesion molecule contactin-associated protein-like 2 (caspr2). this protein plays an important role in the trafficking of kv1 channels under the myelin sheath in the juxtaparanodal region of myelinated axons. it is mostly present in the neurons of the limbic system, basal ganglia, and other motor related and sensation areas (qin, yang, zhu, wang, \& shan, 2021). this distribution explains the diverse clinical manifestations of the disease, primarily characterized by cognitive impairment. other manifestations include cerebellar ataxia, hyperkinetic movement disorders (hmds), seizures, and neuropathic pain, which all typically develop around 10.4 months after onset. at last visit, memory impairment is seen in 69% of the patients, cerebellar ataxia in 42% of the patients, and functional dependency in 25% of the patients. even though most patients' symptoms improve with immune-active treatments, up to 69% of them have long-term memory impairments due to damage to hippocampal structures (benoit et al., 2023). research has primarily focused on understanding the disease's clinical features, underlying mechanisms, and potential treatment options. on the other hand, it is shown that mris performed at baseline show signal changes in the hippocampus in 62-71% of the patients, and these changes are subject to variations in subsequent follow-up scans, that differ widely among patients as mentioned before (bien et al., 2017). and since the dynamics of hippocampal volume changes and its association with the development of hippocampal atrophy and long-term cognitive impairment are not well studied yet in caspr2-le, we primarily aim to examine the longitudinal changes of hippocampal volume in anti-caspr2 limbic encephalitis (caspr2-le) patients to examine whether it correlates to the development of anterograde amnesia and hippocampal atrophy on follow-up.


Eligibility criteria:
inclusion criteria: * patients with a definite diagnosis of caspr2-antibody-associated encephalitis * available mri records * ascertained positivity for caspr2-antibodies in csf exclusion criteria: * positivity for another antibody against neural or glial antigens * mri images not available * not enough clinical data to ascertain outcome

Keywords: autoimmune encephalitis, caspr2 antibodies, mri
alterations in spinal alignment and mobility in individuals with arthroscopic rotator cuff repair

Conditions: Rotator Cuff Tears; Posture; Spinal Curvatures; Arthroscopic Surgery

Summary: the aim of this observational study was to the alterations in spinal alignment in individuals who have undergone rc surgery and revealed the differences compared to healthy individuals.

shoulder dysfunctions are thought to be predisposed by poor posture and muscle imbalances. the shoulder functionality could be limited or worsened by a restricted range of motion (rom) of the spine. evidence from studies evaluating both people with shoulder pain and asymptomatic participants indicates a relationship between a decreased thoracic kyphosis and an increased shoulder rom. therefore, a higher thoracic kyphosis may be linked to a lower rom in the shoulder. shoulder dysfunction becomes more common after the age of 40, and the relationship between spinal posture and shoulder dysfunction is crucially needed to be assessed. the aim of this observational study was to the alterations in spinal alignment and mobility in individuals who have undergone rc surgery and revealed the differences compared to healthy individuals. this cross-sectional observational study was conducted with patients who underwent arthroscopic rm surgery and healthy volunteers.

Eligibility criteria:
inclusion criteria: * those who had undergone the same arthroscopic rm surgical procedure and technique * had undergone acromioplasty and/or tenodesis with rm repair * had undergone arthroscopic rm surgery from the upper extremity of the dominant side; * had completed six months following surgery; were able to perform active shoulder elevation movements of 90° or more * were between the ages of 40 and 75 * were volunteers to participate in the study. exclusion criteria: * who had undergone previous shoulder surgery or revision surgery, subscapularis tendon repair in addition to rm repair, scoliosis surgery, or any surgeries to limit spine motion, as well as those with a history of upper extremity fractures, diabetes mellitus, hypertension, cardiovascular disease, or chronic respiratory diseases that could limit the test's ability to be accomplished
the influence of blood sampling technique on the total amount of blood collected for laboratory testing critically ill pediatric patients

Conditions: Iatrogenic Anaemia

Summary: the aim of this prospective randomized study is to evaluate blood loss caused by laboratory blood draws in patients in the paediatric icu (intensive care unit) of a tertiary hospital among two groups of patients with established long-term or mid-term intravenous access. in the first group, patients will undergo blood draws using the standard method. in the second group of patients, blood draws will be performed using a closed system.

anaemia is one of the most common comorbidities among patients hospitalized in intensive care units. hospital-acquired anaemia (haa) is a newly developed anaemia that occurs during hospitalization in patients who were not anaemic prior to admission. patients with haa have a higher risk of developing complications such as infections, muscle weakness, and neurocognitive developmental disorders; an increased incidence of blood and blood product transfusions (and related complications); longer hospital stays, and higher morbidity and mortality. according to available data, the incidence of anaemia in adults hospitalized in the icu ranges from 40 to 74%. there a feq data describing anemia in critically ill pediatric patients, with the estimated incidence being up to 50%. the etiology of haa is multifactorial and is related to the severity of the underlying disease (sepsis, coagulation disorders, bleeding, renal failure, malnutrition, bone marrow suppression, decreased erythropoietin production, etc.). another factor contributing to the development of anaemia in critically ill patients is iatrogenic blood loss caused by blood draws for laboratory testing. in addition to the standard blood collection method, closed-loop sampling (in-line sampling) can also be used, with studies in adult patients showing a reduction in the amount of blood drawn, ranging from 20 to 80% after its implementation.

Eligibility criteria:
inclusion criteria: * signed informed consent for the study. * patients with established intravenous access: cvc (central venous catheter), cicc (centrally inserted central catheter), picc (peripherally inserted central catheter), mvc (midline venous catheter), venous port, from which blood can be drawn. * anticipated length of stay in the icu more than 24 hours exclusion criteria: * age outside the specified range. * peripheral venous access only. * anticipated length of stay in the icu less than 24 hours. * organ donors. * lack of consent from the legal representative/patient.

Keywords: paediatric patient patient blood management paediatric icu
safety and efficacy of inhaled treprostinil in patients with pah

Conditions: Pulmonary Arterial Hypertension

Summary: to evaluate the effect of inhaled treprostinil compared to placebo on exercise capacity and time to clinical worsening.


Eligibility criteria:
eligible subjects must: * be between 18 and 75 years of age at screening (as defined by date of informed consent is signed), * have a diagnosis of idiopathic or heritable pah, pah associated with connective tissue disease (ctd), pah associated with repaired congenital systemic-to-pulmonary shunts (at least 1 year since repair) or human immunodeficiency virus (hiv) infection, or pah associated with appetite suppressant or toxin use. * be treatment naïve, or receiving background pah therapies (e.g., phosphodiesterase type-5 inhibitor (pde-5i)and / or endothelin receptor antagonist (era)) for less than 1 year prior to screening. * have a 6mwd at baseline (as measured by the mean value of two 6mwt separated by at least 24 hours, but no more than 14 days) that is between 150 - 500 meters, inclusive.
long-term efficacy of ablative fractional laser-assisted photodynamic therapy for treatment of lower extremity bowen's disease

Conditions: Bowen's Disease

Summary: er:yag ablative fractional laser-assisted methyl aminolevulinate photodynamic therapy (afl-pdt) has shown significantly higher efficacy and a lower recurrence rate at 12 months than methyl aminolevulinate photodynamic therapy (mal-pdt) for treatment of bowen's disease (bd). however, long-term follow up data are not available.

to compare the long-term efficacy and recurrence rates of afl-pdt and standard mal-pdt for the treatment of lower extremity bd.

Eligibility criteria:
inclusion criteria: * •patients aged 18 years or more who diagnosed as bowen's disease exclusion criteria: * pregnancy or lactation * active systemic infectious disease * other inflammatory, infectious, or neoplastic skin diseases in the treated area * allergy to mal,other topical photosensitizers, or excipients of the cream * history of photosensitivity * use of immunosuppressive or photosensitizing drugs * participation in any other investigational study in the preceding 30 days * history or indicators of poor compliance * histological findings of acantholysis, desmoplasia, perineural or lymphovascular invasion, and echographic features of regional lymph node metastasis were the disease-specific exclusion criteria

Keywords: ablative fractional laser photodynamic therapy protoporphyrin ix methy-aminolevulinate
blind assessment of the concordance between the administered treatment and the recommendations of a medical algorithm decision support software in systolic heart failure

Conditions: Hearth Failure, Systolic

Summary: the premedic is a prospective, observational study. patients hospitalized for systolic heart failure will be enrolled and health data will be collected at hospital admission and during hospital stay. no data will be collected before detailed information is given to the patient and a non-opposition is obtained. the aim of this observational and prospective study is to evaluate the concordance actual patient management during the in hospital treatment of heart failure and the therapeutic proposals from a medical algorithmic decision support software.

main objective: the aim of this observational and prospective study is to evaluate retrospectively the concordance between the actual systolic heart failure patient management during the inhospital treatment of heart failure (as recorded from the usual healthcare data collected) and the therapeutic proposals from a medical algorithmic decision support software. secondary objectives: to study the evolution of biological, hepatic and cardiopulmonary ultrasound usual markers in hospitalization, in connection with the duration of hospitalization and drug administered.

Eligibility criteria:
inclusion criteria: * 18 years old or over * patients hospitalized for decompensated systolic heart failure * patients informed exclusion criteria: * patients unwillingness to participate

Keywords: systolic heart failure medical algorithm decision support system
well-being and stress control after colorectal surgery

Conditions: Patients with Colorectal Cancer; Surgery

Summary: the criteria usually considered to evaluate the quality of life are the presence or absence of a stomy, alteration of the transit or the sexual dysfunctions. quality of life has been improved by introducing an enhanced postoperative rehabilitation program after surgery (eras). it is a multidisciplinary medical and paramedical care aimed at minimizing the sources of stress allowing a significant reduction in postoperative complications and length of stay. however, the emotional feelings of patients, their fatigue, the quality of their relationships with others and their experience of the disease are not usually considered. nevertheless, these criteria influence the quality of life and constitute the fundamental bases of the psychological well-being, essential in the recovery processes. we propose to enrich the eras program by introducing an individualized support of well-being and stress management aimed at increasing the quality of life of patients. the purpose is to make the patient more autonomous by allowing him/her, to implement stress management exercises. the main goal of the project is to improve the psychological well-being of patients operated on for colorectal cancer by offering stress management sessions in order to promote postoperative rehabilitation. the secondary objectives are to demonstrate the impact of stress management sessions on the length of stay and to study the link between the efficiency of these sessions and the quality of life of patients before the surgery.


Eligibility criteria:
inclusion criteria: * patient undergoing colorectal cancer surgery * regulated surgery * with or without radiation treatment and / or preoperative chemotherapy. * patient benefiting from a social protection scheme exclusion criteria: -- limitation of linguistic or cognitive abilities interfering with the understanding of the study protocol * absence of the consent form of the study * emergency surgery * stomy closure * patient diagnosed psychotic. * patient with "psychiatric disorder" left to the discretion of the investigator

Keywords: colorectal cancer well-being stress recovery
the effect of breastfeeding on the development of appendicitis in adults

Conditions: Appendicitis

Summary: appendectomy is the most common emergent operative procedure performed worldwide. in this study investigators will investigate if there is a relationship between breast feeding and appendicitis in adults.

acute appendicitis accounts for the commonest indication for emergency visits during daily surgical practice. breast feeding is very important both mother and the child. for the infant, breast feeding has an important role on the maturity of immune system. in the literature search, there are a little studies about the relationship between the breast feeding and appendicitis. in the literature, some studies suggests that the breast feeding may possibly give protection against the development of appendicitis. but the number of the patients and the control groups are limited. because of that the investigators have planned to make this study with a lot of number of patients.

Eligibility criteria:
inclusion criteria: * subjects has pathologically proven appendicitis for appendicitis group. exclusion criteria: * subjects has american society of anesthesiologists physical status classification 4, * subject has pregnancy, * subject has malignity, * subject has chronic illness, * subjects who won't accept to join the study * subjects who don't have family members

Keywords: appendix breastfeeding adult
reducing perioperative s. aureus transmission

Conditions: Staphylococcus Aureus; Health Care Associated Infection; Health Care Worker Patient Transmission

Summary: the purpose of this study is to prevent the spread of s. aureus, a dangerous bacterium, within the operating room and between patients undergoing surgery.

the purpose of this study is to prevent the spread of s. aureus, a dangerous bacterium, within the operating room and between patients undergoing surgery. the investigators will combine several approaches in a "bundle" of activities to achieve this goal. the bundle will include removal of bacterial pathogens from patient skin sites before surgery, from provider hands before, during, and after surgery, from environmental surfaces before and after terminal cleaning, and from the injection ports of patient intravenous catheters. the investigators will use a new surveillance system to evaluate how well the bundle, and each component of the bundle, is working. surveillance will identify s. aureus transmission events, and movement of s. aureus between reservoirs before, during, and after surgery (perioperative). surveillance will map transmission events to identify actionable steps to improve the bundle. an infection control perioperative team will act on the surveillance reports to proactively address the action items, and to measure the effect of their efforts for the treatment group. the investigators will compare perioperative s. aureus transmission events for patients receiving the bundle to perioperative s. aureus transmission events for patients receiving usual care.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * undergoing surgery (orthopedic total joint, orthopedic spine, gynecological/oncology, thoracic, general, hernia, colorectal, open vascular, plastic surgery and open urological) * ability to sign informed consent * require general or regional anesthesia exclusion criteria: * less than 18 years of age * inability to sign informed consent * procedures not included above * not requiring general or regional anesthesia
effect of consumption of orafti® inulin on bowel motor function in subjects with constipation

Conditions: Healthy; Constipation

Summary: investigation of the effects of a four week daily consumption of orafti® inulin on bowel motor function in subjects with constipation.


Eligibility criteria:
inclusion criteria: * healthy volunteers without clinical diagnosed diseases with relevant effect on the gastrointestinal system or on visceral motility. * constipation defined as an average of 2-3 stools per week. volunteers should have had constipation for at least the previous 6 months. * age ≥ 20 and ≤ 75 exclusion criteria: * subject under prescription for medication for digestive symptoms such as antispasmodic, laxatives, anti-diarrheic drugs or other digestive auxiliaries. * relevant history, presence of any medical disorder or chronic intake of medication/dietary supplements potentially interfering with this trial. * subjects with stool frequency of \<1 stool every 7 days or more than 3 stools per week.

Keywords: stool frequency bowel motor function orafti® inulin dietary fiber
comparing outcome of thoracocentesis and pigtail catheter drainage in treatment of patients with hepatic hydrothorax

Conditions: Hepatic Hydrothorax

Summary: hepatic hydrothorax (hh) is a pleural effusion that develops in a patient with cirrhosis and portal hypertension in the absence of cardiopulmonary disease (lv et al., 2018). several factors are known to contribute to the development of effusion; the most accepted mechanism of which is the direct delivery of ascitic fluid from the peritoneal cavity to the pleural cavity by "positive" intra-abdominal pressure and a "negative" intrathoracic pressure of the pleural cavity through microscopic congenital diaphragmatic defects (han et al., 2022).


Eligibility criteria:
inclusion criteria: * patients who met the following inclusion criteria were enrolled: * liver cirrhosis (with or without hepatocellular carcinoma). * hepatic hydrothorax (bilateral or unilateral). exclusion criteria: * patients with a pleural effusion due to a condition other than hh. * who had a diagnosis of tuberculosis pleurisy, parapneumonic effusion, inflammatory pleuritis, other neoplasms, and congestive heart failure.
combined transcranial and peripheral muscle magnetic stimulation in chronic tinnitus

Conditions: Chronic Tinnitus

Summary: magnetic stimulation of the brain (repetitive transcranial magnetic stimulation) and of neck muscles (repetitive peripheral muscle stimulation) is used to alter tinnitus-related cortical activity and neck muscles tension.

chronic tinnitus is characterized by several comorbid disorders. one of them is neck and back pain. here, we investigate the feasibility, safety and clinical efficacy of the combination of repetitive transcranial magnetic stimulation (rtms) and peripheral muscle stimulation (rpms) in chronic tinnitus in a pilot study. rtms is considered to interact with neural tinnitus networks. rpms is suggested to bring relief to muscle tension. this is an one arm study where explorative analyses will be done with special consideration on patients suffering from neck pain in the analysis.

Eligibility criteria:
inclusion criteria: * diagnosis of bothersome, subjective chronic tinnitus * duration of tinnitus more than 6 months exclusion criteria: * objective tinnitus * treatable cause of the tinnitus * involvement in other treatments for tinnitus at the same time * clinically relevant psychiatric comorbidity * clinically relevant unstable internal or neurological comorbidity * history of or evidence of significant brain malformation or neoplasm, head injury * cerebral vascular events * neurodegenerative disorder affecting the brain or prior brain surgery * metal objects in and around body that can not be removed * pregnancy * alcohol or drug abuse * acute neck or back pain * neck or back pain of unknown etiology * implants in the neck or back, that are sensitive to magnetic fields
study of the no-touch saphenous vein graft

Conditions: Coronary Artery Disease; Coronary Artery Stenosis; Graft Failure; Cardiac Ischemia; Surgery

Summary: authors hypothesize that "no-touch" saphenous vein as i graft is superior over conventional "no-touch" saphenous vein as free graft in the incidence of graft patency.

a multicenter single blind prospective randomized superiority study is conducted. our hypothesis is that there is difference in the incidence of "no-touch" saphenous vein graft patency using it as the conventional free graft (group c) and i graft (group i) for myocardial revascularization more than 28%. if there is truly difference between groups, then total 106 patients for both groups are required to be 90% sure that the upper limit of a one-sided 95% confidence interval would reveal a difference in favour of the "no-touch" saphenous vein i graft of 28%. the blinding process is applied to a patient, who is informed about received harvesting method of saphenous vein, but don't know the type of the graft cofiguration. the study was approved by institutional review board. depending on a type of the procedure, the patients are divided into two groups: conventional free graft (group c) 53 patients and i graft (group i) 53 patients. randomization is conducted befor operation by using accidental sampling.

Eligibility criteria:
inclusion criteria: * patients with coronary artery disease requiring three-vessel myocardial revascularization * patient consent to the study exclusion criteria: * the diameter of the target arteries for conduits of the internal mammary arteries is less than 1 mm * hemodynamically significant atherosclerosis of the subclavian arteries in the first segment * stenosis of the right coronary artery less than 90% * concomitant pathology requiring additional simultaneous surgical correction * lack of ima * copd with fev1 \<60% * bmi \>35 * prior heart surgery * oncological diseases with a life expectancy of less than 5 years * acs * ckd stage 4 and higher * the diameter of the svg is less than 2 mm or its varicose expansion is more than 6 mm * clti iib and more * atherosclerosis of the brachiocephalic artery more than 50%

Keywords: no-touch saphenous vein graft; cabg