Kornimate/medical-research-clean huggingface dataset:
the importance of inflammatory markers calculated from preoperative and postoperative peripheral blood results in the diagnosis and treatment of patients operated for hydatid cyst of the lung (lung echinococcus granulosus)

Conditions: Lung Hydatid Cyst

Summary: this study aims to investigate the role of these laboratory findings in the differential diagnosis and management of pulmonary hydatid cyst (phc) by examining the number of euzonophils, neutrophils, lymphocytes, platelets and neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and systemic immune inflammatory index values in the peripheral blood of patients diagnosed with pulmonary hydatid cyst (phc) in the preoperative period and post-operative 3rd month. although we have extensive data on hydatid liver cysts, there is limited information in the literature on the laboratory values of patients with phc. this study aims to provide more scientific basis for the diagnosis and management of phc and is considered as an inexpensive, reproducible and easily calculable method to improve the accurate diagnosis and management of akh in clinical practice.

hydatid cyst of the lung (hcc) is a health problem caused by a small species of tapeworm called echinococcus granulosus, a parasitic infection that can occur in humans and other mammals. hydatid cysts are cysts caused by the larvae of the parasite. they most commonly form in the liver and lungs, but can also occur in other organs. e. granulosus lives in the intestines of animals and excretes them in their feces. humans can get the eggs of this parasite through contact or under poor hygiene conditions. the ingested eggs hatch in the stomach and intestine and the larvae enter the bloodstream, then form cysts in various organs throughout the body. cystic echinococcosis is a disease in which a large group of patients live in conditions of material and social poverty. the disease has a widespread distribution worldwide and the regions with high disease prevalence are southeast europe, the middle east, north, central and east asia and south america.

Eligibility criteria:
inclusion criteria: * between january 1, 2022 - december 1, 2023, patients with hydatid cyst of the lung who were hospitalized in the thoracic surgery service exclusion criteria: * between january 1, 2022 and december 1, 2023, other patients admitted to the thoracic surgery service

Keywords: lung hydatid cyst neutrophils, lymphocytes, platelets
fecal microbiota transplantation (fmt) for clostridium difficile

Conditions: Clostridium Difficile Infection

Summary: faecal microbiota transplantation (fmt) is used for recurrent clostridium difficile infection (rcdi) as part of an quality improvement initiative and conducted within the framework of center for faecal microbiota transplantation at aarhus university hospital (cefta).

patients are assessed, treated and monitored at aarhus university hospital (auh) as an integrated part of the project.

Eligibility criteria:
inclusion criteria: * age 18 or higher * documented recurrence of clostridium difficile exclusion criteria: * none
hvpg-guided therapy vs carvedilol plus endotherapy for the prevention of esophageal variceal rebleeding in cirrhotic patients

Conditions: Liver Cirrhoses; Variceal Hemorrhage; Esophageal Varices

Summary: variceal bleeding is a major complication of cirrhosis, associated with a hospital mortality rate of 10%-20%. surviving patients are at high risk for recurrent hemorrhage. for these reasons, management should be directed at its prevention. endoscopic variceal band ligation (ebl) in combination with non-selective β-blocker (nsbb) therapy is the recommended first line therapy. transjugular intrahepatic portosystemic stent-shunt (tips) is the most effective method to prevent rebleeding, however, it is burdened with increased hepatic encephalopathy and deterioration of liver function in patients with advanced cirrhosis. so tips placement forms an alternative if first line therapy fails. hepatic venous pressure gradient (hvpg) is currently the best available method to evaluate the presence and severity of portal hypertension. patients who experience a reduction in hvpg of ≥20% or to \<12mmhg in response to drug therapy are defined as 'responders'. the lowest rebleeding rates are observed in patients on secondary prophylaxis who are hvpg responders. a recent meta-analysis has demonstrated that combination therapy is only marginally more effective than drug therapy. this suggests that pharmacological therapy is the cornerstone of combination therapy. adding ebl may not be the optimal approach to improve the outcome of hvpg nonresponders and hvpg non-responders are a special high-risk population that may benefit from a more aggressive approach, such as an early decision for tips. it recently was shown that tips placement within 72 hours after acute bleeding not only prevented recurrent bleeding but also improved survival. these raise the question of whether ligation together with nsbb should remain the first choice for elective secondary prophylaxis. therefore, the purpose of the study is to compare whether hvpg-guided therapy is superior to standard combination therapy for the prevention of variceal bleeding in patients with decompensated cirrhosis.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of liver cirrhosis * history of esophageal variceal bleeding confirmed by endoscopy * time interval between index bleeding and randomization \> 5 days. * child-pugh score \< 12，meld score\<19 exclusion criteria: * clinical manifestation of active bleeding * gastric variceal bleeding: gov2，igv1 or igv2 * degree of main portal vein thrombosis \> 50% * refractory ascites * contraindications of tips * contraindications of nsbb * budd-chiari syndrome * malignancy tumor * uncontrolled infections * history of portal-systemic shunt surgery * hiv * pregnancy or breastfeeding woman * poor incompliance

Keywords: transjugular intrahepatic portosystemic shunt endoscopic variceal ligation non-selective β-blocker therapy hepatic venous pressure gradient
whole body vibration and diabetes type 2

Conditions: Diabetes Mellitus, Type 2

Summary: diabetes generates a great impact on society, as well as a concern for health professionals due to its high and increasing prevalence; there are more and more studies that demonstrate the effectiveness of vibration platforms and their benefits at a physiological level. the objective is to analyze the decrease in glycosylated hemoglobin and glycemia levels after the use of whole body vibration platforms and the possible inclusion of this therapeutic option within the usual treatments.the sample will be composed of people diagnosed with type 2 diabetes mellitus in the plasencia area (cáceres, extremadura). participants will be randomly assigned to the intervention or control group using a randomization list and will follow the inclusion criteria: healthy type 2 diabetics between 50 and 60 years of age and not taking diabetes medication. all participants will undergo a determination of glycosylated hemoglobin, blood pressure, lipid profile, weight and height, and different functional tests such as tug, 10mmt, 5sts. the experimental group will perform a full body vibration intervention on an oscillating platform for 12 weeks with a weekly frequency of 3 non-consecutive days and a duration of 12 minutes. the exercises will consist of 60 seconds of work and 60 seconds with rest. the control group will carry out their normal life insisting on the importance of glycemic controls before and after their daily physical exercise.


Eligibility criteria:
inclusion criteria: * not taking medication for diabetes. exclusion criteria: * suffer a pathology (such as diabetic retinopathy, diabetic nephropathy), mobility disability and/or comorbidities incompatible with physical exercise and the use of vibration platforms, previous hip or knee surgeries, cognitive impairment and neurological pathology

Keywords: whole body vibration
study of the prevalence of sexual dysfunction in women after rectal cancer surgery and analysis of the impact of a sexologist intervention

Conditions: Rectal Tumor; Women; Sexuality; Life Quality

Summary: rectsexqol is a study aiming at determining the prevalence of female sexual dysfunction after rectal cancer surgery. it has the goal as well to analyse the impact of an intervention given by a sexologist to such patients.

the treatment of rectal cancer is multimodal combining surgery, chemotherapy and radiotherapy. each therapeutic tool may affect the sexual life of treated patients. the incidence of sexual dysfunction in patients with rectal cancer varies according to literature from 5 to 88%. this may be due to the lack of a common definition relating to sexual dysfunction making it difficult to compare results. on the other hand, it should be noted that all of the work related to sexual dysfunction after treatment for rectal cancer is mainly interested in men. the sexual well-being of women treated for rectal cancer is based on the assessment and management of their sexual functions as well as that of their overall sexual health in a personalized manner. the establishment of a sexology consultation before and after such a surgical procedure could improve the sexual functions as well as the sexual well-being of these women. the main aim of our study is to evaluate the prevalence of sexual dysfunctions at m-1 (before treatment) in the two cohorts "here" and "elsewhere" in the context of surgery for rectal cancer in females. the second aim will be to determine the impact of sexology consultation in the cohort "here" in comparison to the standart cohort without any intervention called "elsewhere".

Eligibility criteria:
inclusion criteria: * women * diagnosis of stage i-iii rectal adenocarcinoma or rectosigmoid junction with anastomosis less than 15 cm from the anal margin * surgical management, preceded or not by radio-chemotherapy, with restoration of continuity * age : over 18 * proficiency in french or english exclusion criteria: * current pregnancy * significant cognitive/psychiatric disorders * guardianship

Keywords: rectal cancer women sexuality quality of life
safety of testosterone undecanoate i.m. in hypogonadal men

Conditions: Hypogonadism

Summary: treatment of male hypogonadism by testosterone substitution has be monitored in terms of safety. this study relates to safety of a new long-acting preparation.

a reliable form of androgen substitution therapy regarding kinetics, tolerance and restoration of androgenicity is paramount in hypogonadal men. intramuscular injection of the long-acting ester testosterone undecanoate (tu) offers a new modality. the objective is to assess safety of tu regarding metabolic and pharmacogenetic confounders in hypogonadal men treated with this new formulation. this is a longitudinal prospective one-arm open intervention and observation trial. a minimum of 5 individual assessments is a prerequisite. investigated modulators of safety parameters entering regression models are: nadir and/or delta total testosterone concentrations, body mass index (bmi), and age. the setting andrological outpatient department.

Eligibility criteria:
inclusion criteria: * men presenting hypogonadism-related symptoms and desiring substitution therapy. such symptoms are fatigue, loss of libido, depressiveness, change in body composition/weight, decreased physical performance, decrease in aggressive behaviour, disability to cope, decreased work performance, lack of androgenization. at least one of these symptoms has to be accompanied by low total testosterone levels (\< 12 nmol / l). * all patients have to give written informed consent for the use of their data for scientific evaluation as approved by the ethics committee of the medical faculty, university of muenster, germany and the state medical board. exclusion criteria: * prostate cancer * breast cancer * desired paternity

Keywords: testosterone hypogonadism safety
a cohort study of pci strategies for severely calcified lesions of complex coronary arteries in the elderly

Conditions: Coronary Heart Disease

Summary: the aim of this observational study is to compare the prognostic outcomes of various pci strategies in elderly patients with complex coronary calcified lesions. the patients will be classified into two groups and assigned different pci strategies, either stenting or stenting combined with pharmacologic balloon implantation. the investigators will assess the one-year prognosis for major adverse cardiovascular events in these patients.


Eligibility criteria:
inclusion criteria: 1. age ≥ 60 years; 2. meet the indications for coronary intervention; 3. ivus examination suggests severe calcified lesions (calcification angle \>270°) or oct examination suggests severe calcified lesions (calcification angle \>180° and/or length \>5mm and/or thickness \>0.5mm); 4. the diameter of the target lesion vessel is greater than 2.75mm; 5. the total length of the lesion is more than 60mm and/or the number of lesions to be treated is ≥3 and/or the number of vessels to be treated is ≥2. exclusion criteria: 1. inability to provide written informed consent; 2. inability to administer antiplatelet agents and anticoagulant therapy; 3. the subject is participating in other unfinished clinical trials; 4. life expectancy \<1 year; 5. non-in situ vascular lesions; 6. patients with haemodynamic instability; 7. previous stroke within 6 months. 8. left main stem lesions.
craniocervical dysfunction index in turkish patients with non-specific neck pain

Conditions: Neck Pain; Craniocervical Disfunction

Summary: the aims of this study were to perform cultural adaptation of the craniocervical dysfunction index in patients with non-specific neck pain, reliability and validity of the index turkish speaking adults.


Eligibility criteria:
inclusion criteria: * between the ages of 20-60 years * clinical diagnosis of non-specific neck pain * being able to communicate in turkish * volunteering to participate in the study exclusion criteria: * over 60 years of age * those with impairments in cervical mobility that affected the postural assessment

Keywords: neck pain craniocervical disfunction reliability validity
acceptability, feasibility, safety and efficacy of a optimized rehabilitation program for treated patients with spinal muscular atrophy (sma).

Conditions: Spinal Muscular Atrophy

Summary: the goal of this study is to investigate the acceptability, feasibility, safety and efficacy of an optimized rehabilitation program for treated patients with spinal muscular atrophy (sma) compared to the current rehabilitation program in the united kingdom. the aim is to provide patients with more hands on physiotherapy and access to rehabilitation devices at home to support parents currently providing rehabilitation on their own.

the main study objective is to investigate whether an optimized rehabilitation program would be accepted and is feasible within the sma patient community. the optimized program will comprise of goal orientated rehabilitation with more frequent hands on physiotherapy (every 2 weeks) as well as a sma approved rehabilitation device used at home on a weekly basis, to provide the most appropriate therapy for each individual patient. all study participants will receive the optimized rehabilitation program over 12 months. an external control group will be used to determine the potential efficacy. research study visits will take place at baseline, month 6 and month 12. at these visits a general physical exam will be undertaken alongside collecting the participant and carer perception, satisfaction and compliancy of the rehabilitation program. motor function assessments according to age and ambulatory status will be assessed to help evaluate potential therapeutic benefits.

Eligibility criteria:
patient participant eligibility criteria: inclusion criteria: * genetically confirmed sma considered as a non-sitter, sitter or walker * post-symptomatically treated and on stable dose for 12 months with any disease-modifying market-approved drug * patients from 1-10 years of age at baseline * parent(s)/legal guardian(s) of patients less than 16 years of age must provide written informed consent prior to the patient's participation in the study * willing and able to comply with all protocol requirements and procedures. exclusion criteria: the participant may not enter the trial if any of the following apply: * any acute or chronic condition which, as assessed by the investigator, significantly interferes with the rehabilitation of the patient * need of diurnal and/or invasive ventilation, naps excluded * currently enrolled in a treatment study; or treatment with an experimental therapy * any surgical and/or medical intervention, according to the investigator, 3 months before baseline and/or during the study participation. carer (considered as participant) eligibility criteria: inclusion criteria: * willing and able to comply with all protocol requirements and procedures * carer's child has been included in study. exclusion criteria: • no exclusion criteria.

Keywords: physiotherapy rehabilitation sma acceptability feasibility united kingdom physical therapy prospective spinal muscular atrophy
haploidentical hematopoietic stem cell transplantation for acute leukemias

Conditions: Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Summary: this is a prospective observational cohort study of haploidentical transplantation with post-transplant cyclophosphamide for acute leukemias using reduced intensity conditioning for acute myeloid leukemia (aml) and myeloablative conditioning for acute lymphoblastic leukemia (all).

hematopoietic stem cell transplantation (hsct) is the most effective treatment for acute myeloid leukemia (aml) and acute lymphoblastic leukemia (all), with the lowest rates of relapse. fertility rate in brazil is falling, and only 25% of people born today will have a matched sibling donor. on the other hand, currently donor non-related to about 50% of patients enrolled in brazilian receptor registry (rereme). consequently, at least 35% of patients won't have a matched donor. the haploidentical transplantation is defined as a partially matched hematopoietic cell transplantation, using a partially matched family donor (parent, sibling or child). haploidentical transplantation activity is growing worldwide, with results comparable matched unrelated donors. the objective of this study is to test the feasibility of haploidentical transplantation with post transplant cyclophosphamide for acute leukemias in a brazil.

Eligibility criteria:
inclusion criteria: * acute lymphoblastic leukemia or acute myeloid leukemia exclusion criteria: * severe comorbidities * second transplant

Keywords: haploidentical hematopoietic stem cell transplantation partially matched hematopoietic stem cell transplantation post-transplant cyclophosphamide hematopoietic stem cell transplantation
pain treatment after total knee replacement - continuous epidural versus intravenous patient controlled analgesia with morphine

Conditions: Pain, Postoperative; Osteoarthritis

Summary: the study purpose is to compare the effectiveness of different methods for post-operative pain treatment after total knee replacement.

total knee replacement (tkr) is known to be one of the most painful surgical procedures. many treatments have been used post tkr: iv opioids, epidural infusions, peripheral nerve blocks. no one method has been recognised as the best one. in this study we will compare two well established methods of pain treatment: 1. continuous infusion of local anesthetics + opioids into the epidural space, 2. patient controlled analgesia with iv morphine. the study design is double blind. patients will have a combined spinal-epidural anesthesia for the operation and then will be connected to 2 different pumps, one to the epidural catheter and one to the intravenous catheter, for the first 24 hours post-operatively. pain scores, total analgesic medications other than study medications, adverse reactions to study medications, complications and patient satisfaction will be followed by blinded observers and compared between groups.

Eligibility criteria:
inclusion criteria: * informed consent * age: 55 to 85 years * osteoarthritis * primary unilateral total knee replacement * american society of anesthesiologists (asa) i-iii * successful spinal epidural anesthesia for surgery exclusion criteria: * any cause for knee replacement other than osteoarthritis * total knee revision (re-do) * any contraindication for regional anesthesia * abnormal coagulation studies * thrombocytopenia less than 100,000/cc * chronic renal failure (creatinine \[cr\] \< 1.8) * neurological disease involving lower extremities * major surgery during the last 2 weeks pre-operatively * current or past drug or alcohol abuse * allergy to study medications * post-operative bleeding over 2000 cc/24 hours * postdural puncture headache after anesthesia performance

Keywords: total knee replacement orthopedic surgery post operative analgesia continuous epidural patients controlled analgesia morphine combined spinal epidural anesthesia anesthesia analgesia epidural marcaine epidural fentanyl pain
technological rehabilitation of distal sensorimotor polyneuropathy in diabetic patients

Conditions: Complications of Diabetes Mellitus; Diabetic Neuropathies

Summary: the investigators evaluated the effectiveness of the application of analysing treadmill, muscle strengthening and balance training compared to a control intervention in patients with diabetic neuropathy.

recent studies witnessed how physical exercise may interrupt the devastating decrease of muscle performance in dsp and further experiments are underway to find more exercises for the recovery of motor function impairment. in fact the rehabilitation treatment, that aims at reducing motor disability, preserving gait functions and preventing falling risks, is an interesting therapeutic approach. literature recommends balance re-training exercises, muscle strengthening, selective stretching and retraining of motor activity. new technologies produced in the recent decades different devices used in strengthening exercises (electromechanical dynamometers), balance recovery (balance platforms) and gait (analyzing treadmills) have visual feedbacks through which the patients may independently monitor accuracy and intensity of their exercises, being therefore strongly motivated and resulting in a high training intensity. these technologies are often used in rehabilitation of different patients, but are rarely employed for dsp. the purpose of this case control study was to examine the effectiveness of the application of analysing treadmill, muscle strengthening and balance training compared to a control intervention in patients with diabetic neuropathy.

Eligibility criteria:
inclusion criteria: * the participants need to have a history of diabetes mellitus type 2, \>3 years, (i.e., time from the diagnosis or the beginning of first related signs or symptoms), * a diagnosis of distal sensorimotor polyneuropathy associated, * able to walk autonomously, eventually with a aid. exclusion criteria: * scoring less than 5 points on the functional independence measure (fim) (7) locomotion scale, * presenting articular ankyloses, contractures, spasms with important locomotion effects, * presenting bony instability affecting lower limb functionality (unconsolidated fractures, vertebral instability, severe osteoporosis), * in presence of attendant clinicopathological conditions contraindicating the rehabilitation treatment (respiratory insufficiency, cardiac/circulatory failure, osteomyelitis, phlebitis and different other conditions), * in presence of cutaneous lesions at lower limbs, * scoring less than 22 points on the mini mental state examination (mmse), * exhibit important behavioural diseases involving aggressivity or psychotic disorders. * had received prior interventions for distal sensorimotor polyneuropathy.

Keywords: exercise therapy