Kornimate/medical-research-clean huggingface dataset:
effect of physical therapy modalities in osteoarthritis

Conditions: Osteo Arthritis Knee; Quadriceps Muscle Atrophy

Summary: the purpose of this study was to find the most effective treatment out of both techniques; dry needling and kinesio taping for treating knee osteoarthritis (oa) in terms of pain, strength, and balance

knee osteoarthritis is also associated with a 50%-60% reduction in maximum quadriceps torque, possibly resulting from disuse atrophy and atherogenic inhibition. kinesio taping is a term that comes from the field of kinesiology, because the application of the tape allows the body to move normally, and reacts to fascia via biomechanical or proprioceptive mechanisms. kinesio tape is an elastic therapeutic tape that finds its application as an adjunct to professional activities in healthcare, rehabilitation, prevention, and sports. in circulatory pathologies, kinesio tape has the function to promote the drainage of excess fluid, activating a lymphatic drainage response. kinesio tape promotes better blood circulation and lymph flow in the treated area, and this principle can be used to drain the swelling in trauma and bruises to speed up the process of redistribution of the hematoma. kinesio tape application decreases the surplus heat via friction reduction resulting in lifting the skin. it also has a good stabilizing effect. kinesio tape was also used for treating sports and orthopedic injuries, and a variety of musculoskeletal disorders like osteoarthritis. for example, the research of murray h. has shown an increase in the electromyographic quadriceps muscular activity with kinesio tape application, applied by patients after acl repair in the postoperative phase. dry is a specific technique for the treatment of functional disorders of the skeleton muscles, fascia, and connective tissue. it can also be used to reduce pain, restore function and reduce structural defects in muscles and joints, the dry needling treatment approaches are based on three models (including models of radiculopathy, spinal sensitization, and myofascial trigger point model). the dry needling technique can be divided into superficial and deep techniques. conservative treatment is advocated in patients with mild to moderate osteoarthritis of the knee. because muscles weakness is associated with pain and physical dysfunction and influences the progression of disease in patients with knee osteoarthritis. muscle strengthening is a key component in knee osteoarthritis therefore, local strengthening exercise is prescribed more frequently than general exercise. a growing body of evidence shows that exercise improves knee joint function and decreases symptoms.

Eligibility criteria:
inclusion criteria: * diagnosed with osteoarthritis. exclusion criteria: * surgical procedures in the lower extremity in the last 6 months * neurological disorders * skin allergy * patient is under pain medications.

Keywords: dry needling kinesio tapping osteoarthritis quadriceps
association between methotrexate erythrocyte polyglutamate concentration and biological drug concentration and clinical response in rheumatoid arthritis patients treated with subcutaneous injectable methotrexate and a first biological drug

Conditions: Rheumatoid Arthritis

Summary: the combination of methotrexate (mtx) with a biological disease-modifying antirheumatic drugs (bdmard) is the next step in treatment with mtx monotherapy in rheumatoid arthritis (ra). estimation of mtx and bdmard impregnation could be performed with the erythrocyte mtx polyglutamate (mtx-pg) and bdmard assays before to move to a second bdmard. in ra patients treated with mtx (prescribed for at least 6 months at a stable dose for at least 3 months) in combination to a first bdmard (prescribed since at least 3 months), an assay of mtx-pg and bdmard will be performed in tow subsets of ra according to the level of disease activity. the first subset is active ra defined by a das28 (disease activity score 28)\>3.2. the second one is ra in clinical remission defined by a das28\<2.6. the main hypothesis is the association between the low concentration of mtx-pg and the clinical response of ra patients treated with subcutaneous methotrexate injection associated to a first bdmard. adherence to mtx will be reviewed by the compliance questionnaire rheumatology (cqr) questionnaire. this assay could be useful to improve mtx management before to move to a second bdmard.


Eligibility criteria:
inclusion criteria: * age \> 18 years and have social security affiliation. * patients followed in the rheumatology department at the hospital of st etienne. * rheumatoid arthritis patients in remission (disease activity score 28\<2.6) with methotrexate (mtx) treatment for at least 6months, and with a stable dose for 3months. * patients with a high disease activity rheumatoid arthritis activity (disease activity score 28\>3.2) with methotrexate (mtx) treatment (≥ 15 mg/week), taking mtx treatment for at least 6months with a stable subcutaneous weekly mtx injection (≥ 15 mg/week) treatment during the previous 3 months. * signed informed consent. exclusion criteria: * patients treated with another conventional synthetic disease modifying anti-rheumatic drugs (csdmard) * another diagnostic than rheumatoid arthritis

Keywords: rheumatoid arthritis methotrexate erythrocyte polyglutamate compliance questionnaire rheumatology
acute effects of handgrip on blood pressure in hypertensive adults

Conditions: Hypertension

Summary: the effect of handgrip training on blood pressure reduction has been demonstrated in several studies. however, acutely, there is still divergence regarding the effects of isometric handgrip exercise on blood pressure responses, especially when it is performed at different times of the day. it is suggested that the magnitude of blood pressure reduction after a single exercise session is able to predict long-term blood pressure behavior. thus, understanding the effects of isometric handgrip exercise, performed at different times of the day, on blood pressure in adult hypertensive individuals acutely may help to understand the effects of this type of exercise chronically.


Eligibility criteria:
inclusion criteria: 1. diagnosis of hypertension controlled by up to three antihypertensive medications; 2. sbp levels ≤ 180 mmhg and/or dbp ≤110 mmhg; 3. no serious heart disease; 4. no upper limb musculoskeletal injury that prevents the handgrip. exclusion criteria: 1. diagnosis of other cardiovascular diseases or diabetes during the study; 2. change the class and/or dose of antihypertensive medication during the study; 3. worsening of the disease (bp \> 180 or use of four or more medications).

Keywords: exercise blood pressure strength training vascular function
effect of adjuvant chemotherapy cycles on patients with node-negative gastric cancer following neoadjuvant chemotherapy

Conditions: Locally Advanced Gastric Cancer

Summary: to explore the effect of adjuvant chemotherapy cycles on the prognosis of this specific patient with lymph node-negative gastric cancer following neoadjuvant chemotherapy.

we analyzed clinicopathological data from patients with lymph node-negative gastric cancer who underwent neoadjuvant chemotherapy at four institutions between 2010 and 2020. the 3-year os was assessed using landmark analysis. independent risk factors associated with 3-year os were identified using a cox proportional hazards regression model.

Eligibility criteria:
inclusion criteria: * (1) preoperative neoadjuvant chemotherapy; (2) primary gastric adenocarcinoma, diagnosed by gastroscopic pathology findings before neoadjuvant chemotherapy in complete pathological remission (pcr) cases or via postoperative pathology findings in all other instances; (3) absence of distant metastases in the liver, lungs, or abdominal cavity, as confirmed by preoperative chest radiography or chest computed tomography (ct), abdominal ultrasonography, abdominal ct, and other imaging; (4) radical gastric cancer surgery (r0) and d2 lymph node dissection; and (5) postoperative pathologic verification of no lymph node metastasis (i.e., lymph node-negative). exclusion criteria: * (1) preoperative radiotherapy or radiochemotherapy, (2) discovery of distant metastases preoperatively or intraoperatively, (3) coexistence of other malignant tumors, (4) residual gastric cancer, and (5) perioperative patient mortality.
transition to infant formula feeding on gastrointestinal regurgitation (tiger) study

Conditions: Gastrointestinal Disorder, Functional; Regurgitation, Gastric; Colic, Infantile; Constipation - Functional; Infant Development

Summary: to compare the frequency of regurgitation and other digestive outcomes between infants who receive an infant formula based on whole goat milk and an infant formula based on cow milk proteins during the transition period from breastfeeding to formula feeding, using predominantly breastfed infants as a reference group.

the study is a randomized, double-blind, parallel-group trial to study the effect of feeding infants goat milk or cow milk formula in the first 6 months of life on the prevalence of functional gastrointestinal disorders and other health outcomes, including gastrointestinal health and sleep during the transition from breastfeeding to formula-feeding. a predominantly breastfed group is used as a reference group.

Eligibility criteria:
inclusion criteria: * healthy full-term born infants (≥ 37 weeks + 0 days and \< 41 weeks + 6 days of gestation) * birth weight ≥ 2.5 kg and ≤ 4.5 kg * born from a singleton pregnancy * live in bangkok or nearby with no plan for geographical migration before 6 months of age * for experimental and active comparator groups only: parent(s) has expressed the intention to partially (in combination with breastfeeding) or fully formula-feed the infant and ready to enroll in the study before the age of 4 months/120 days * for no intervention group only: parent(s) has expressed the intention to predominantly breastfeed (according to study definition) and ready to enroll in the study before the age of 4 months/120 days * infant has been predominantly breastfed for at least 2 weeks before enrollment * parent(s) has sufficient thai language skills to understand the study information, the informed consent, and to comply with the study procedure * parent(s) is willing and deemed able to fulfil the requirements of the study protocol and procedures * at least one parent is of legal age of consent exclusion criteria: * infant has any disorder considered to interfere with nutrition, growth or development of the immune system * participation of the infant in any other interventional trial or participation of the mother in any intervention trial with infant follow-up * for experimental and active comparator groups only: infant has been formula-fed for more than 1 week before enrolment * for experimental and active comparator groups only: cow milk allergy or intolerance of the infant * for experimental and active comparator groups only: enrolled infant who never consumed any study product until the first visit 2 weeks following enrolment

Keywords: infant formula goat milk regurgitation
neurohumoral control of intestinal electrical and mechanical activity

Conditions: Morbid Obesity

Summary: a collaborative research project with dr. kathleen keef (department of physiology, university of nevada school of medicine, reno, nevada) studying the role of putative neurotransmitters in human intestine.

segments of intestine from patients undergoing elective gastric bypass for morbid obesity or resections for non-obstructive neoplasms at the uc davis medical center will be used. samples will be taken from tissue normally removed and sent to pathology or discarded. full thickness segments of intestine (10 mm x 1 mm) will be prepared for recording either intracellular electrical activity or mechanical contraction. the effects of putative non-adrenergic, non-cholinergic neurotransmitters (e.g., nitric oxide) will be studied. the source of the tissue will not be identified either directly or indirectly through identifiers associated with the measured responses.

Eligibility criteria:
inclusion criteria: * all patients having elective bowel resection exclusion criteria: * entire resected segment required for pathology * ischemic/necrotic disease

Keywords: intestinal smooth muscle gi motility
comparison of ideal vs. actual weight base factor dosing

Conditions: Hemophilia A

Summary: this is a randomized, prospective, multicenter study to examine whether or not the current recommended factor dosing strategy - i.e., dosing by actual body weight - in overweight and obese patients with hemophilia a may deliver excessive clotting factor to achieve the desired result of bleeding prevention and cessation. this study also examines ways to prevent delivering excessive factor by using a patient's ideal body weight as a new dosing strategy compared to the current dosing strategy. the hypothesis being tested is that factor dosing based on ideal body weight will result in protective factor levels.

this is a randomized, prospective, multicenter, open-label, crossover study to examine whether or not the current recommended factor dosing strategy, i.e., dosing by actual body weight in overweight and obese patients, may deliver more clotting factor than necessary to cause bleeding to stop in participants with hemophilia a who use factor viii (fviii). this study also examines ways to prevent delivering too much factor by using a participant's ideal body weight as a new dosing strategy compared to the current dosing strategy. the hypothesis being tested is that factor dosing based on ideal body weight will result in hemostatic factor levels. the study will be conducted at the washington center for bleeding disorders (wcbd) at bloodworks northwest, oregon health \& science university (ohsu), seattle children's hospital (sch), and providence sacred heart children's hospital (sh). cumulatively across the four sites, up to 20 participants will be enrolled. randomization will be performed centrally at wcbd. participants will provide their own factor. prior to the first study-related dose, participants will stop taking any fviii products for either 48 hours if currently using a short-acting fviii product or 72 hours for a long acting fviii product. factor levels will be measured immediately before and at multiple points after two different factor doses. subjects will be randomized to start their dosage based either on actual body weight or ideal body weight first and then crossover to receive dosage based on the other category.

Eligibility criteria:
inclusion criteria: * hemophilia a * able and willing to comply with pharmacokinetic testing schedule * either overweight or obese bmi using cdc definitions by age exclusion criteria: * inhibitor of \> 0.6 bu twice in the past, or documented abnormal recovery of less than 66% (of expected) in the past * known other bleeding disorder * known other prolongation in aptt (lupus anticoagulant, fxii deficiency) * female

Keywords: hemophilia a fviii ideal body weight actual body weight
prophylactic closed incision negative pressure wound therapy on abdominal wounds - clinical and economic perspectives

Conditions: Wound Infection; Surgical Site Infection; Surgical Wound; Surgical Incision

Summary: this study evaluates whether specialist negative pressure dressings reduce the risk of wound infections after operations when compared to conservative dressings, and if one negative pressure dressings works better than another. the study will look at patients who have had an open operation on their bowel and the wound closed at the end of the operation.

surgical site infections (ssi) can affect up 41% of patients post-operatively. they are associated with significant healthcare and patient costs, and increased patient morbidity and mortality. specialist post operative dressings with negative pressure wound therapy are available, and the who do recommended for use in high risk wounds, taking resources into account. however no further recommendations are available. this study will explore the rate of post-operative wound infections in adult patients undergoing open abdominal surgery on the bowel, and compare the rate of wound infections in these patients in relation to three different dressing types used after their operation. the study aims to determine if any of the dressings used within the study are associated with lower post-operative wound infection rates, and compare the overall costs of using each dressing type, including both direct healthcare costs and societal costs. finally, it will evaluate participant's quality of life outcomes after open abdominal surgery, specifically relating to their wound.

Eligibility criteria:
inclusion criteria: * emergency, trauma or elective contaminated abdominal operations within general surgery and/or colorectal surgery * abdominal wounds closed at time of operation and expected to heal by primary intention * patients who have the capacity to consent * to include complex abdominal wounds with existing infection where wounds have been closed and expected to heal by primary intention * to including graft or flap sites as part of general surgical procedure * patients who are able to complete questionnaires post operatively, either alone or with assistance exclusion criteria: * wounds where an appropriate seal cannot be obtained * wounds left open and expected to heal by secondary intention * patients known to have allergy or sensitivity to dressings being used * patients who lack the capacity to consent

Keywords: surgical site infections negative pressure wound therapy contaminated abdominal wounds closed incision abdominal wound prophylactic therapy
assessment of the effects of access count in percutaneous nephrolithotomy on renal functions by technetium-99m-dimercaptosuccinic acid scintigraphy

Conditions: Renal Parenchymal Loss After the Percutaneous Nephrolithotomy

Summary: in this study 37 patients who had undergone percutaneous nephrolithotomy were included. preoperative dmsa scans were performed a day before the surgery, whereas postoperative scans were randomized by evaluating them before (n=25) and after (n=12) the 6th postoperative month. a dmsa scan was read by using a technique that divides both kidneys into three paired poles. in this way functional changes were investigated in the renal units. twenty six of 37 cases underwent percutaneous nephrolithotomy with a single access site and 11 with multiple access sites. when each of the poles of a kidney was admitted as a surgical unit separately, there were 51 units.

total 37 patients who had undergone pcnl were included between june 2007-june 2009. all patients were evaluated routinely with physical examination, complete blood count (cbc), blood urine nitrogen (bun), creatinine levels, and urinalysis. none of the patients had experienced pyelonephritis, and none had a solitary kidney, renal ectopy or history of any other urinary abnormality. at least one of the following techniques; namely computed tomography (ct), intravenous urography or ultrasonography, was preferred routinely before surgery in order to visualize the urinary system. unilateral pcnl was performed in all patients. postoperative cbc and bun creatine levels were repeated. preoperative dmsa scans were performed a day before the surgery, whereas postoperative scans were randomized to indicate early and late term. the aim of randomization was to determine an optimal time for assessing patients. a dmsa scan was read by using a technique that divides both kidneys into three paired poles. in addition the uptake of all opposite poles was measured together and calculated as a percentage value separately (figure-1), e.g., the two upper poles' uptake was measured together as if they were renal units and each poles' own portion in this total uptake was declared separately as a percentage. how the differential functions were changed between the sides undergoing pcnl and the opposite sides, as well the changes before and 6 months after surgery are manifested by using these parameters. twenty six of 37 cases underwent pcnl with a single access site (70.3%) and 11 separately with multiple accesses (29.7%). when each of the poles of a kidney was considered as a surgical unit, there were 51 units. in this manner the functional change of a unit would show the surgical trauma inflicted on the poles by pcnl access.

Eligibility criteria:
inclusion criteria: - patients with renal stones which was bigger than 2cm. exclusion criteria: * patients with acute urinary tract infection, * patients with bleeding disorder, * patients with chronic renal failure, * patients with solitary kidney, renal ectopy or history of any other urinary abnormality.

Keywords: percutaneous nephrolithotomy urinary stones 99m-technetium-dimercaptosuccinic acid
ex vivo test of new stroke treatment using magnetic nanorobots

Conditions: Thrombosis

Summary: tissue plasminogen activator (tpa) is the fda approved thrombolytic drug for patients with acute ischemic stroke. while transcatheter endovascular therapy is widely accepted as an effective method for targeted blood vessels via a catheter to elicit ischemic necrosis. to improve targeting accuracy administrated tpa and avoiding collateral tissue damage, we developed a magnetic nanorobotic system to active system to active intravenous delivery of tpa for targeted thrombus removal. here human placenta will be used as an ex vivo model for human cerebral vascular system in our ex vivo thrombolysis study. our magnetic nanorobotic system encapsulated with tpa overcomes the limitations of passive thrombolytic therapy with tpa alone and will be a promising approach for the treatment of ischemic stroke and other thrombotic diseases


Eligibility criteria:
inclusion criteria: * healthy pregnant women at 20-45 years of age of any ethic origin, giving childbirth with natural delivery or caesarean sections after 37-42 weeks of gestation. * healthy singleton pregnancy. * participant able to give voluntary, written, informed consent to participate in the study. exclusion criteria: * abnormal prenatal development (e.g intrauterine growth restriction) * early preterm birth \< 37 weeks * verbal confirmation of hypercholesterolemia * family history of stroke or vascular disease * type i or type ii diabetes and gestational diabetes * cancer, except skin cancers completely excised with no chemotherapy or radiation with a follow up that is negative. * clinically significant abnormal laboratory results at screening. * any other active or unstable medical condition. * history of liver disease. * history of hypertension (including pre-eclampsia)