Kornimate/medical-research-clean huggingface dataset:
a comparison of 000-0551 lotion versus vehicle lotion in subjects with plaque psoriasis (study -305)

Conditions: Plaque Psoriasis

Summary: this phase 3 study has been designed to determine and compare the efficacy and safety of 000-0551 lotion and vehicle lotion applied twice daily for two weeks in subjects with plaque psoriasis.


Eligibility criteria:
inclusion criteria: * subject has a clinical diagnosis of stable plaque psoriasis involving a minimum of 2% and no more than 12% affected body surface area. * subject has an investigator's global assessment (iga) score of at least three (moderate) at study start. * if subject is a woman of childbearing potential, she must have a negative urine pregnancy test and agree to use an effective form of birth control for the duration of the study exclusion criteria: * subject has spontaneously improving or rapidly deteriorating plaque psoriasis. * subject has guttate, pustular, erythrodermic or other non-plaque forms of psoriasis. * subject has used any phototherapy (including laser), photo-chemotherapy or other forms of photo based therapy for the treatment of their psoriasis within 30 days prior to study start. * subject has used any systemic methotrexate, retinoids, systemic corticosteroids \[including intralesional, intra-articular, and intramuscular corticosteroids\], cyclosporine or analogous products within 90 days prior to study start. * subject has used any systemic biologic therapy (i.e., fda-approved or experimental therapy) within five half-lives of the biologic prior to study start. * subject had prolonged exposure to natural or artificial sources of ultraviolet radiation within 30 days prior to study start or is intending to have such exposure during the study. * subject has used topical body (excluding the scalp) psoriasis therapy (including coal tar, anthralin, steroids, retinoids, vitamin d analogs) within 14 days prior to study start. * subject has used emollients/moisturizers on areas to be treated within four hours prior to clinical evaluation at study start. * subject is currently using lithium or plaquenil (hydroxychloroquine). * subject is currently using a beta-blocking medication (e.g., propanolol) or angiotensin converting enzyme (ace) inhibitor at a dose that has not been stabilized. * subject is pregnant, lactating, or is planning to become pregnant during the study. * subject is currently enrolled in an investigational drug or device study. * subject has used an investigational drug or investigational device treatment within 30 days prior to study start. * subject has been previously enrolled in this study and treated with a test article.

Keywords: psoriasis lotion investigator's global assessment
digital respiratory game in asthma

Conditions: Asthma in Children

Summary: this study aims to examine the effects of a digital game designed for respiratory training in childhood asthma. fifteen children aged 8-14 years with asthma were included in the study. there were two groups a digital game group (n=9) and a control group (n=6). respiratory training was given to the digital game group with a digital game. the control group was followed with medication. both groups were evaluated at baseline and after 3 weeks.

asthma is a chronic obstructive disease that is common in children worldwide. this study aims to examine the effects of a digital game designed for respiratory training in childhood asthma. fifteen children aged 8-14 years with asthma were included in the study. there were two groups a digital game group (n=9) and a control group (n=6). demographic information of the children was recorded. pulmonary function test (pft) was evaluated with a portable spirometer (spirobank mir), the quality of life of the children was evaluated with the paediatric asthma quality of life questionnaire and psychological status was evaluated with the child depression scale. respiratory training was given to the digital game group with a digital game. the control group was followed with medication. both groups were evaluated at baseline and after 3 weeks.

Eligibility criteria:
inclusion criteria: * diagnosed with asthma according to gina criteria * cooperative exclusion criteria: * presence of neurological problems * presence of systemic disorders

Keywords: digital game pediatric asthma quality of life respiratory training psychological status
a study to compare two anti-hiv drug combinations

Conditions: HIV Infections

Summary: the purpose of this study is to compare 2 anti-hiv drug combinations.

patients are stratified by hiv rna: 5,000-75,000 vs greater than 75,000 copies/ml by amplicor assay. patients are randomized to two arms. arm a receives sqv plus rtv plus two nrtis. arm b receives efv plus two nrtis. patients must take their dose at approximately the same time every day. patients have the option of taking daily dose in am or pm. patients are evaluated for changes in plasma hiv rna levels and cd4/cd8 counts and for adverse experiences and laboratory determinations. evaluations are made every 4-8 weeks until week 48. patients continuing beyond week 48 who reach weeks 60, 72, 84, and common study closure, will be seen at those weeks.

Eligibility criteria:
inclusion criteria patients may be eligible for this study if they: * are hiv-positive. * have a viral load of at least 5,000 copies/ml and a cd4 cell count of at least 75 cells/mm3. * are at least 18. * are able to complete the study. exclusion criteria patients will not be eligible for this study if they: * have taken any anti-hiv medications for more than 2 weeks. * are pregnant or breast-feeding.

Keywords: drug therapy, combination saquinavir hiv protease inhibitors ritonavir dosage forms reverse transcriptase inhibitors anti-hiv agents efavirenz
tourniquet vs. no tourniquet during total knee arthroplasty

Conditions: Osteoarthritis

Summary: the purpose of this study is to correlate functional outcomes and perioperative complications with tourniquet use during total knee arthroplasty.


Eligibility criteria:
inclusion criteria: 1. all unilateral primary knee arthroplasties performed by investigators participating in this study will be eligible for inclusion 2. diagnosis of osteoarthritis exclusion criteria: 1. revision surgery 2. bilateral knee surgery 3. age \ 80 4. bmi \>40 5. baseline lower extremity strength less than 5/5 6. vascular calcifications 7. history of chronic narcotic use, defined as more than 5mg of oxycodone q4 hours 8. functionally limiting spine disease 9. other functionally limiting lower extremity disorder (i.e. symptomatic ipsilateral hip disease) 10. patients who cannot perform the baseline functional tests 11. allergy/contraindication to protocol medications 12. post-traumatic arthritis 13. inflammatory arthritis 14. pregnancy 15. prisoners 16. patients receiving care as part of a worker's compensable injury
diesel exhaust particles and leukotriene production

Conditions: Allergic Rhinitis

Summary: the purpose of this study is to measure the effects of allergens and/or diesel exhaust particles in the nose to learn more about allergic responses in individuals with cat allergic rhinitis.


Eligibility criteria:
inclusion criteria: 1. age 18 to 65 years old. 2. positive prick (epicutaneous) skin test to standardized cat with a wheal equal to or greater than 3 mm and with a surrounding flare. 3. ability to give informed consent. exclusion criteria: 1. pregnancy or breast-feeding. (pregnancy and the period during breast feeding can affect nasal congestion and be a confounder in this regard.) 2. systemic corticosteroid use within the previous three months or anytime during the challenge protocol. 3. topical nasal corticosteroid use within the past month or anytime during the challenge protocol. 4. systemic antihistamines or decongestant use within past two weeks or anytime during the trial. 5. chronic sinusitis or chronic non-allergic rhinitis. 6. use of reserpine. 7. cigarette smoking within the past year or during the challenge protocol 8. use of topical nasal antihistamines, chromoglycolates (chromolyn, cromlon®), decongestants or non-steroidal anti-inflammatory agents (nsiads) within the preceding week or anytime during the challenge protocol. 9. present or treatment within the past 10 years with allergy immunotherapy (injections). 10. present or past treatment with anti-ige therapy. 11. any unusual exposure to air pollutants (e.g., working as a diesel mechanic) that, in the opinion of the investigators, might compromise the individual's ability to participate in the study. 12. living arrangement where the subject has a cat dwelling within the subject's habitation. 13. any serious heart, lung, neurological or kidney disease that in the opinion of the investigators would impair the individual's ability to participate in the study. 14. use of asthma-required medications.

Keywords: cat allergic rhinitis
clinical and genetic factors associated with psychotic symptoms among cocaine abusers

Conditions: Cocaine-induced Psychotic Disorder During Intoxication

Summary: the aim of this study is to determine the clinical, genetic and environmental factors associated with the phenotype "severe psychotic symptoms" caused by cocaine.

the second purpose is to include gene x environment interaction and to analyse the factors associated with the presence or the absence of severe psychotic symptoms induced by cocaine.

Eligibility criteria:
inclusion criteria: * adults, cocaine users, who have signed an informed consent exclusion criteria: * poor venous condition (for blood samples), specially protected people, non french speaking, people who refuse to sign the consent.

Keywords: cocaine cocaine-induced psychosis genetic clinical biological
effect of vitamin d supplementation on coronary calcification and parathyroid hormone in ckd patients

Conditions: Chronic Kidney Disease; Vitamin D Deficiency

Summary: the investigators hypothesize that the chronic kidney disease patients who suffer from vitamin d deficiency will be benefit from given vitamin d2 because coronary artery calcification and hyperparathyroidism will be improved.

we will call for 350 ckd patients (250 ckd3-5stage and 100 ckd5d stage)who suffer from vitamin d deficiency.they will be divided into 2 groups. one group will be given vitamin d and the other will not. they will take coronary artery ct test every year(in 2 years).we will compare the coronary calcification progression between the 2 groups.

Eligibility criteria:
inclusion criteria: * chronic kidney disease patients (3-5d) * serum 25（oh）d \< 40nmol/l(16ng/ml)，serum calcium \< 2.55mmol/l（10.2mg/dl）； * willing to sign * could obey the follow up design exclusion criteria: * allergy to vitamin d * heart failure (nyha more than 2 grade) * pregnant * malignant tumor * critical hepatic disease * taking vitamin d or analogue in 3 recent months * taking other clinical trial

Keywords: the 25(oh) vitamin d level the 1.25(oh) vitamin d level the intact pth level the calcification score of coronary artery the microalbuminuria level
direct measurement of food intake behaviour in obese women before and after bariatric surgery or lifestyle intervention

Conditions: Bariatric Surgery Candidate; Lifestyle; Obesity

Summary: to assess changes in food intake and food preference (e.g., fat and sugar) after bariatric surgery and lifestyle intervention alone with a direct measurement.


Eligibility criteria:
inclusion criteria: * woman * age between 18 and 67 years of age (standard for eligibility for bariatric surgery) * patients must be able to adhere to the study visit schedule * independently mobile * patients must be able to give informed consent (ic) prior to any study procedures * surgical (1) and non-surgical (2) groups: 1. eligible for bariatric surgery (bmi \> 35 kg/m2 and clinically indicated bariatric surgery operation in agreement with the ifso criteria) 2. patients with a bmi of 30-40 kg/m2, who are planning to join the cool-lifestyle program exclusion criteria: * pre-operatively/lifestyle group: factors impairing ability to consume meal such as: significant dysphagia; gastric outlet obstruction; anything factor that prevents subjects from drinking or eating a meal * post-operatively: factors impairing ability to consume meal such as: significant and persistent surgical complications or anything that prevents subjects from drinking or eating a meal. * systemic or gastrointestinal condition which may affect food intake or preference (including diabetes mellitus) * pregnancy or lactation, or planning to get pregnant during the study period * patients who have an intolerance or allergy for one of the components of the test product (e.g. lactose) * active and significant psychiatric illness including substance misuse * significant cognitive or communication issues * medications with documented effect on food intake or food preference * participating in another scientific study at the same time, if
effects of touch massage in the sub-acute phase after stroke

Conditions: Stroke

Summary: the aim is to study effects of touch massage in the sub-acute phase after stroke in two main areas; general health and independence.the hypothesis are that; touch massage in the sub-acute phase after stroke decreases anxiety and pain, increases health related-quality of life, decrease physiological stress responses, increase sensorimotor function, decrease disability, and increase activity in sensorimotor areas and decrease redundant brain activity in motor-related areas.

despite high quality stroke care in sweden, decreased sensorimotor function, anxiety and pain remains one year after stroke and lead to impaired health and dependence as well as high health care costs. it is therefore urgent to find new rehabilitation strategies. there is some knowledge about effects of touch massage among healthy and patients with ill-health conditions but no study have evaluated touch massage in the sub-acute phase of stroke. therefore the aim in this project is to study effects of t touch massage in the sub-acute phase after stroke in two main areas; general health and independence.

Eligibility criteria:
inclusion criteria: * stroke defined according to trial of org 10172 in acute stroke treatment (toast) and the oxford community stroke project classification (ospc), * impaired finger tapping on the affected side of the body, * the ability to flex the wrist 20° from substrate on affected side of the body exclusion criteria:individuals with * cancerous tumors, * infections with fever, * neurologic or psychiatric disease, * alcohol or drug addiction, * conditions that impede communication.

Keywords: stroke massage general health independence
pancreatic cancer registry: for any person with a personal or family history

Conditions: Pancreatic Cancer, ATM, BRCA, Hereditary Cancer

Summary: the nfptr was established in 1994 to find the causes of pancreatic cancer. in brief, the investigators are interested in both the genetic and non-genetic causes of pancreatic cancer. the investigators are particularly interested in finding the genes that cause pancreatic cancer to cluster in some families. up to 10% of pancreatic cancer patients have another close relative who has also developed pancreatic cancer. this clustering of pancreatic cancers in families has yet to be explained; however, the investigators continue to identify new familial pancreatic cancer genes that explain this clustering in subsets of families. for example, in 2009 and 2012 the investigators discovered that mutations in the palb2 and atm genes jointly account up to 5% of the clustering of pancreatic cancer in families.


Eligibility criteria:
inclusion criteria: * personal or family history of pancreas tumors exclusion criteria: * none
effects of duloxetine on pain relief after total knee arthroplasty in central sensitization patient

Conditions: Osteoarthritis

Summary: this study aims to compare the effectiveness of duloxetine after total knee arthroplasty in central sensitization patient. central sensitization plays an important role in the chronic pain experienced by osteoarthritis patients.elimination of the nociceptive input from the damaged joint by total joint arthroplasty was not always followed by a complete resolution of symptoms. patients with high levels of preoperative pain and low pain thresholds had a higher risk of persistent pain after total knee arthroplasty (tka), which has been interpreted as evidence of central sensitization. thus, the presence of central sensitization before surgery in osteoarthritis patients may be an important contributing factor to postoperative pain versus adequate analgesia. preclinical models of central sensitization suggest that duloxetine is effective in the treatment of persistent pain. investigators will compare the pain following tka of central sensitization patients in duloxetine group (n=50) with those in non-duloxetine group (n=84). investigators will classify the central sensitization patients by central sensitization inventory and divide the central sensitization patients in to 2 groups (duloxetine and non-duloxetine group) randomly. investigators checks the visual assessment scale at preoperative, postoperative 1, 2,6,12 weeks. all participants will receive postoperative pain control after tka using the same pain control regimen except duloxetine.

both groups of participants will receive pain control regimens as follows: preemptive analgesia : celebrex celecoxib, lyrica pregabalin, patient controlled analgesia (postoperation 28 hours), during admission : celebrex 200mg#1, ircodon 5mg 2tablets#2, ultracet 2t#2 (postoperation 1 week) discharge medication: celebrex 200mg 1capsule#1 x 5 weeks, ultracet 2t#2 x 1 week drug generic names: celecoxib (celebrex), pregabalin (lyrica), acetaminophen/tramadol (ultracet er), oxycodone (ircodon)

Eligibility criteria:
inclusion criteria: * patients for total knee arthroplasty * having medicare insurance * csi(central sensitization inventory)\> 40 (central sensitization patient ) exclusion criteria: * rheumatoid arthritis * other inflammatory arthritis * neuropsychiatric patients * allergy or intolerance to study medications * patients with an asa(american society of anesthesiologist) classification of iv (angina, congestive heart failure, dementia, cerebrovascular accident) * chronic gabapentin or pregabalin use (regular use for longer than 3 months) * chronic opioid use (taking opioids for longer than 3 months) * alcohol, drug abuser * narcotics addiction

Keywords: total knee arthroplasty duloxetine
prevention or treatment of arterial hypotension and oxygen cerebral saturation during major abdominal surgery

Conditions: Hypotension During Surgery; Hemodynamic Instability

Summary: in this study investigators will explore the association between intraoperative arterial hypotension and cerebral oxygen saturation in patients scheduled for major abdominal surgery. investigators will assign patients to control or interventional group. in this last group arterial hypotension will be avoided based on a hpi (hypotension predictive index) protocol. in the control group arterial hypotension will be promptly treated according to hemodynamic variables.


Eligibility criteria:
inclusion criteria: * patients scheduled for abominal surgery exclusion criteria: * emergency surgery * end-stage renal disease * pregnancy * obesity * atrial fibrillation * previous cerebral ischaemia * central nervous system disorders * severe cardiac valvular disease
coronary disease and the effect of high-intensity interval training

Conditions: Coronary Disease

Summary: the primary purpose of this study is to investigate if systematic, high intensity, interval-based aerobic exercise training results in regression of lipid content of atherosclerotic coronary artery plaques, and in reduction of plaque burden in patients with stable coronary heart disease. composition and morphologic characteristics of plaques will be studied by intra-coronary near-infrared spectroscopy (nirs) and intravascular ultrasound (ivus) in patients undergoing percutaneous coronary intervention.


Eligibility criteria:
inclusion criteria: * stable coronary artery disease * will undergo cardiac catheterization * will be treated with percutaneous coronary intervention (pci) * signed written informed consent * able to execute the intervention exclusion criteria: * earlier bypass surgery * known inflammatory disease other than atherosclerosis * planned surgery within 4 months * included in another randomized controlled study

Keywords: coronary angiography exercise
peroneal muscles response to expected and unexpected falls among young and middle-aged adults before and after neuromuscular training

Conditions: Healthy Participants

Summary: proper functioning of the ankle musculature, specifically peroneal muscles, is crucial for maintaining balance and reducing the risk for falls. evidence suggests that a decrease in aspects of neuromuscular control already starts at midlife (45-65 years). however, there is almost no information regarding the function of the ankle muscles at the middle-age as most experiments have compared young (\ 65 years). moreover, neuromuscular training can improve the function of ankle muscle in response to perturbation; yet, no previous study has compared the level of effectiveness between middle-aged and young adults.


Eligibility criteria:
inclusion criteria: - healthy participants exclusion criteria: * neurological disease accompanied by motor, sensory or cognitive impairment. * illness or condition that does not allow strenuous activity. * significant orthopedic injury to the back or lower limbs in the last six months, which limits strenuous activity or weight-bearing. * history of orthopedic injury that includes injury to the knee or ankle ligaments. * taking medications that may affect stability or balance. significant visual impairment that is not corrected using glasses/contact lenses * pregnancy