Kornimate/medical-research-clean huggingface dataset:
diagnosis of postoperative atrial fibrillation by a smartwatch

Conditions: Atrial Fibrillation; Cardiac Surgery

Summary: the incidence of postoperative atrial fibrillation (poaf) after on-pump cardiac surgery remains high, at around 30%. poaf increases the risk of cardiac decompensation, stroke, acute myocardial infarction, and death, resulting in increased morbidity and mortality, hospital length of stay, and cost of patient management. episodes of poaf are usually paroxysmal and asymptomatic, increasing the risk of developing permanent af at five years by 4 to 5 times. poaf occurs between 3 and 4 days after cardiac surgery, mainly when the patient is hospitalized in a surgical ward without heart rate monitoring as opposed to critical care, where the patient benefits from continuous rhythmic monitoring. the diagnosis of poaf is therefore made with the help of a 12-lead electrocardiogram (ecg) when the patient presents clinical symptoms and when the medical staff notes a significant variation in heart rate. however, many patients with episodes of asymptomatic poaf have a higher risk of stroke and mortality than those with symptomatic poaf. faced with this public health problem, the development of tools for diagnosing af is in full swing, mainly the marketing of smartwatches (sws) that allow for the performance of 1-lead ecg. sw is also equipped with algorithms to analyze heart rate variability and diagnose asymptomatic atrial fibrillation (af) episodes. the european society of cardiology (esc) and the european association for cardio-thoracic surgery (eacts) recommend the use of smartwatches to detect af, in particular, to reduce the economic impact of af. the aim of the study is to diagnose poaf within the first five days after patient discharge from the critical care unit for the cardiac surgery department.


Eligibility criteria:
inclusion criteria: * adult patient (\>18 years old) * the patient was hospitalized at amiens university hospital for on-pump cardiac surgery. * the patient has had a recent on-pump cardiac surgery (\< 96h) * patient with the motor and cognitive abilities to perform a 1-lead ecg with the smartwatch * the patient was transferred to the cardiac surgery department of amiens university hospital. * the beneficiary of a social security plan * signature of the consent to participate in the study exclusion criteria: * history of af * need for rhythmic monitoring by telemetry in cardiac intensive care for atrioventricular block and rapid supra and ventricular rhythm disorder (\>140 bpm). * an external pacemaker connected to epicardial electrodes depends on ventricular and atrial pacing. * patients already included in an interventional clinical research protocol may alter the incidence of poaf. * pregnant woman

Keywords: smartwatch atrial fibrillation perioperative atrial fibrillation cardiac surgery
model study on cervical cancer screening strategies and risk prediction

Conditions: Cervical Cancer Screening; Risk Assessment; Artificial Intelligence; Machine Learning

Summary: by collecting non-image medical data of women undergoing cervical screening in multiple centers in china, including age, hpv infection status, hpv infection type, tct results, and colposcopy biopsy pathology results, a multi-source heterogeneous cervical lesion collaborative research big data platform was established. based on artificial intelligence (ai) machine learning, cervical lesion screening features are refined, a multi-modal cervical cancer intelligent screening prediction and risk triage model is constructed, and its clinical application value is preliminarily explored.

by collecting non-image medical data of women undergoing cervical screening in multiple centers in china, including age, hpv infection status, hpv infection type, tct results, and colposcopy biopsy pathology results, a multi-source heterogeneous cervical lesion collaborative research big data platform was established. based on artificial intelligence (ai) machine learning, cervical lesion screening features are refined, a multi-modal cervical cancer intelligent screening prediction and risk triage model is constructed, and its clinical application value is preliminarily explored. the effect of clinical application of the model was evaluated by internal data from fujian province and external data from several other regions in china.

Eligibility criteria:
inclusion criteria: * age 25-64 years old; * there was no history of precancerous lesions or cervical cancer; * no previous cervical surgery or cervical removal; exclusion criteria: * hpv test results are not available; * pregnant or lactating women; * there is a serious immune system disease, and the disease is active;
sabr for renal tumors

Conditions: Renal Tumor

Summary: renal cell carcinoma (rcc) is the most common type of kidney cancer. the usual treatment for this type of cancer is surgery. considering the most common patients are an average age of 65 and some are not suitable candiates for surgery, there is great interest in non-surgical alternatives for kidney cancer treatments. this study will investigate the use of stereotactic ablative radiosurgery (sabr) for renal tumors. sabr is a non-invasive alternative, which involves delivery of high doses of radiation to the target, while minimizing the risk of injury to the surrounding organs. patients will be seen before and end of treatmetn and will be followed at 4 month intervals for up to 2 years. during the follow ups, patients will be asked to complete a quality of life questionnaire and will have standard of care imaging.


Eligibility criteria:
inclusion criteria: * solid kidney mass (primary rcc or metastasis) amenable to sabr ≤6cm * histological or radiological diagnosis of renal tumor * inoperable: high risk for surgery or declined surgery * ecog performance status of 0-3 exclusion criteria: * ≥5 active metastases * sysstemic therapy (except endocrine therapy) wthin 6 days prior to sabr * prior abdominal radiotherapy with fields overlap resulting in excessive doses to the involved kidney * patients with end stage renal failure \> 4(kdoqi guidelines) * familial syndrome: von hippel-lindau disease, polycystic kidney disease, hereditary papillary rcc or tuber sclerosis

Keywords: stereotactic body radiation therapy sabr radiation therapy renal cell carcinoma rcc
endometrial local injury and implantation failure

Conditions: Infertility

Summary: the purpose of this study is to evaluate the influence of endometrial biopsy on increasing implantation rate in patients with recurrent implantation failures, 93 women with at least two implantation failures were evaluated. in case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group. the results suggest that in vitro fertilization or intracytoplasmic sperm injection after endometrial biopsy increase pregnancy outcome.

in a randomized control trial study, 93 women with at least two implantation failures were evaluated. in case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group. the implantation rate was determined as 10.9% in biopsy group compared with 3.38% in controls. clinical pregnancy rate was significantly higher in case group than controls (27.1% and 8.9% respectively

Eligibility criteria:
inclusion criteria: * women with recurrent implantation failure which was defined as 2-6 cycles unsuccessful of ivf-et in which more than 10 high grade embryo were transferred exclusion criteria: * age over than 40 years old * poor responders to ovarian stimulation

Keywords: endometrial biopsy ivf/icsi pregnancy outcome recurrent implantation failure
human amniotic epithelial cells for treatment of bronchial fistula

Conditions: Bronchial Fistula

Summary: bronchial fistula (bf), an abnormal passage or communication between a bronchus and another part of the body, may develop when there are penetrating wounds of the thorax and after lung surgery. without effective therapy, treatment of bf is a challenge, with a high rate of mortality and teratogenicity. the investigators will conduct endoscopic injection of human amniotic epithelial cells to fistula, observe the recovery of bronchial fistula and systemic reactions, to investigate the application of human amniotic epithelial cells in the treatment of bronchial fistula.


Eligibility criteria:
inclusion criteria: * diagnosed with bronchial fistula by imaging or bronchoscopic examination * typical symptom of bronchial fistula, such as fever, cough, purulent sputum, weight loss... * patients present compromised conditions, who can only accept a conservative treatment. exclusion criteria: * absolute contraindication of bronchoscopic examination and treatment * with previous treatment of cell therapy, including stem cells.
microcirculation guided therapy versus "standard treatment" of severe sepsis

Conditions: Severe Sepsis; Microcirculation

Summary: the purpose of this study is to asses the recovery of organ failure between two resuscitation protocols in severe sepsis: standard, pressure guided therapy versus a microcirculation guided therapy

despite continued improvements in medical therapy, mortality from septic shock has remained between 30% and 70% for the past three decades with only a slight decrease in mortality rate. standard treatment of septic shock is fluid resuscitation, followed by agents with vasopressor activity to correct hypotension in septic shock. the question rises whether vasopressors should be the first line of action in septic shock opening and recruiting the microcirculation are expected to improve regional organ function and tissue distress in severe sepsis. beside fluid resuscitation, vasodilatation, in this respect, enhances microcirculatory flow while vasoconstriction causes a reduction in microcirculatory flow. on the other hand, a minimal perfusion pressure should be present. our aim is to asses the effects of two resuscitation protocols in severe sepsis: the "standard treatment" using predefined pressure goals versus a microcirculation guided therapy.

Eligibility criteria:
inclusion criteria: * age 18 years or older * admission to the intensive care unit with severe sepsis, defined in according with a modification of the american college of chest physician/sccm guidelines criteria * intention to provide full intensive care treatment for at least 72 hours and * written informed consent to be obtained from patient or next of kin. exclusion criteria: * haematologic malignancy * metastatic malignancy * aids with cd4 \< 50 cells/mm3 * liver cirrhosis child pugh b \& c * pregnancy * post resuscitation with gcs \< 8 of 15 and treatment with induced hypothermia

Keywords: sepsis severe sepsis microcirculation orthogonal polarisation spectral
mesenchymal stem cells for progressive multiple sclerosis_sweden

Conditions: Autologous Mesenchymal Stem Cells; Multiple Sclerosis

Summary: to assess the safety of a single dose of iv infusion of bone-marrow derived autologous mesenchymal stem cells (mscs) in multiple sclerosis (ms) with progressive disease status.


Eligibility criteria:
inclusion criteria: 1. diagnosis of ms 1. active relapsing remitting ms (rrms) as evidenced by presence of ≥ 1 clinically documented relapse in the past 12 months or ≥2 clinically documented relapses in the last 24 months. 2. secondary progressive ms with clinical progression as evidenced by an increase of 1 edss point (or 0,5 p if edss ≥ 5 at time for study start) in the last year or evidenced by ≥1 relapse or ≥ gel at mri performed within the last year. 3. primary progressive ms with clinical progression as evidenced by an increase of 1 edss point (or 0,5 p if edss ≥ 5 at time for study start) in the last year. 2. age_ 18-65 years 3. disease duration: 2-20 years 4. edss 3,0-7,0 exclusion criteria: 1. subtype of ms not fulfilling inclusion criteria 2. treatment with any immunosuppressive therapy, including natalizumab and fingolimod, within the 3 months prior to randomization 3. treatment with interferon-beta or glatiramer acetate within the 30 days prior to randomization 4. treatment with corticosteroids within the 30 days prior to randomization 5. relapse occurred during the 60 days prior to randomization 6. previous history of a malignancy other than basal cell carcinoma of the skin or carcinoma in situ that has been in remission for more than one year 7. severely limited life expectancy by another co-morbid illness 8. active or chronic severe infection. 9. history of previous diagnosis of myelodysplasia or previous hematologic disease or current clinically relevant abnormalities of white blood cell counts 10. pregnancy or risk or pregnancy (this includes patients that are unwilling to practice active contraception during the duration of the study) 11. egfr \< 60 ml/min/1.73m2 or known renal failure or inability to undergo mri examination. 12. inability to give written informed consent in accordance with research ethics board guidelines

Keywords: mesenchymal stem cells multiple sclerosis
meditation for depression and anxiety symptoms in dialysis patients

Conditions: Depression; Anxiety

Summary: this study examines the use of brief meditation interventions for patients with symptoms of anxiety and depression who are undergoing dialysis. half of the participants will receive meditation interventions 3 times a week, while the other half will receive treatment as usual. this study will examine whether meditation is feasible and whether it has any effect on reducing symptoms of anxiety or depression.

roughly 50% of people who undergo dialysis experience stress, anxiety or depression, but often these conditions go undetected and untreated. it is known that meditation is helpful for anxiety and depression, especially in people who have chronic health conditions. this study will look specifically at meditation interventions tailored to the dialysis setting. patients on maintenance hemodialysis with anxiety and depression will be recruited from hemodialysis units. recruitment will start at the jewish general hospital in march 2016. recruitment may later expand to university health network (toronto), and/or other sites affiliated with mcgill university or university of toronto. participants will then be randomly assigned to receive meditation or continue with their usual treatment. the participants assigned to the meditation group will practice several meditation techniques with a trained interventionist 3 times a week, during their dialysis sessions. at the end of the 8 weeks, the investigators will assess whether the meditation intervention was feasible (i.e. whether recruitment goals were met and drop out rates were as expected). participants in the meditation group will be asked to rate whether they enjoyed the meditation on a scale. both the participants assigned to the meditation group and to the usual treatment group will be asked to rate their depression and anxiety symptoms on the phq-9 and the gad-7 scales to evaluate whether there was any change.

Eligibility criteria:
inclusion criteria: * patients currently receiving maintenance hemodialysis * patients with depression and/or anxiety as indicated by scores of ≥10 on the patient health questionnaire (phq-9) and/or general anxiety disorder-7 (gad- 7) * normal cognition or mild cognitive impairment ("normal" result on the 3-minute mini-cog test) exclusion criteria: * mild, moderate, or severe dementia ("abnormal" result on the 3-minute mini-cog test) * acute psychotic symptoms * acute suicidal ideation/intent

Keywords: meditation dialysis
longitudinal observational study in prematurely born preschool children: assessment of lung function parameters

Conditions: Asthma; Allergic Rhinitis

Summary: the pre-ar project is a longitudinal observational study. the primary objective is the assessment of lung function parameters in late preterm preschool children.

the pre-ar project is a longitudinal observational study. the primary objective is the assessment of lung function parameters in late preterm preschool children. pulmonary function tests will be performed.

Eligibility criteria:
case group inclusion criteria: * premature birth \< 37 weeks * 5 years old ≤ age ≥ 3 years old control group inclusion criteria: * full-term birth * 5 years old ≤ age ≥ 3 years old exclusion criteria of both groups: * pulmonary bronchodysplasia (bdp) * acute respiratory infection * immunological and metabolic system disease * malformation of upper respiratory tract * topical or systemic therapies, with antibiotics, antihistaminics and corticosteroids, in the previous 30 days * patients with neurological pathologies * patients that are not able to perform the lung function tests

Keywords: asthma allergic rhinitis children atopy
optimizing pharmacotherapy for bipolar alcoholics

Conditions: Bipolar Disorder; Alcohol Dependence

Summary: the purpose of this study is to test the efficacy of naltrexone and valproate in the treatment of comorbid bipolar disorder and alcohol dependence.

bipolar disorder has the highest rate of association with alcohol and other substance use disorders. this complex clinical presentation is asociated with severe disabilities,morbidity and heightened risk for suicide. there is a significant gap in our knowledge regarding effective treatment interventions for this high risk clinical population. this proposal will test the efficacy of a promising pharmacological approach for the treatment of comorbid alcohol dependence and bipolar disorder. we propose a randomized, double blind, placebo controlled 12-week trial to test the efficacy of valproate plus naltrexone vs. valproate alone in decreasing alcohol use and stabilizing mood symptoms among patients with comorbid alcohol dependence and bipolar disorder. all participants receive supportive psychosocial treatment.

Eligibility criteria:
inclusion criteria: * subjects will meet diagnostic and statistical manual-iv (dsm-iv) criteria for current alcohol dependence and a concurrent bipolar disorder exclusion criteria: * 1) schizophrenia, schizoaffective and any nonbipolar psychotic disorder, unipolar major depression, primary anxiety disorder,mental retardation and signs of impaired cognitive functioning. * 2) opiate dependence, abuse, or on opioid maintenance treatment for any reason and those with positive urine screen for opiate. * 3)current dsm-iv criteria for dependence on substances other that alcohol, cannabis,nicotine or caffeine. * 4) neurological conditions including epilepsy, history of brain injury,encephalitis or any organic brain syndrome or documented focally abnormal eeg. * 5)medical conditions including severe cardiac, liver, kidney, endocrine, hematologic, or other impairing medical conditions, or impending surgery * 6)pregnancy * 7)inability or unwillingness to use contraceptive methods * 8)any medical condition or other reason that in the opinion of the investigator would prevent the subject from completing the protocol

Keywords: alcoholism bipolar disorder pharmacotherapy naltrexone
evaluation of the effect of labio-lingual spring hawley and clear aligners on periodontal health and salivary parameters

Conditions: Anterior Crossbite

Summary: objective: the aim of our study was to determine the effect of two different types of removable appliances on periodontal health, dental plaque colonization, as well as saliva, ph, flow rate, and buffering capacity of the patients. method: a total of 30 pediatric patients aged 7-12 years were treated with a total of 30 appliances including 15 clear aligners (group a) and 15 labiolingual spring hawleys (group b). in the clinical examination of the patients, dental caries status was evaluated by dmft and dft index, periodontal health status was evaluated by probing pocket depth measurements and plaque, gingival and probing bleeding indices. in addition, saliva and dental plaque samples were taken and salivary parameters and microbiologic structure of plaque were analyzed. all these procedures were performed in 2 different time periods for each patient; before and after the treatment. the results were statistically evaluated using spss (spss statistics v23.0 for windows, chicago, il, usa).

in the clinical examination of the participants, dental caries status was evaluated by dmft and dft index, and periodontal health status was evaluated by probing pocket depth measurements; pi, gi, sdi. in addition, saliva and dental plaque samples were taken and salivary parameters (flow rate, ph and buffering capacity) and microbiological structure of plaque were analyzed.

Eligibility criteria:
inclusion criteria: • dental anterior crossbite exclusion criteria: * skeletal anterior crossbite * systemic disease * regular medication use

Keywords: clear aligner labiolingual spring hawley oral health
cerebral oxygenation in septic patients using vasopressors - the conscious study

Conditions: Septic Shock

Summary: the purpose of this study is to reveal if higher doses of vasopressors in septic shock patients correlates with cerebral vasoconstriction and lower cerebral oximetry.

the mortality with septic shock is high. treatment includes antibiotics, intravenous fluid and drugs for circulatory support, especially the vasopressor norepinephrine. fluids and drugs for circulatory support are to restore adequate organ perfusion. inadequate oxygenation of the brain can give neurologic damage. traditionally treatment is guided by surrogate markers like arterial and central venous pressure. cerebral oximetry is a non-invasive method which measures cerebral saturation of oxygen, sco2, and thereby expresses regional cerebral perfusion. by registering cerebral oxymetry on patients treated with vasopressors for septic shock we want to reveal if higher doses of vasopressor correlates with cerebral vasoconstriction and lower cerebral oximetry.

Eligibility criteria:
inclusion criteria: * 18 years or older * septic shock patients in icu department requiring vasopressor therapy exclusion criteria: * damage to the frontal lobes corresponding to the area where sco2 is monitored * patients in pharmacological studies * patients with known intracranial vascular anomalies or cerebral aneurysms * patients where vasoactive medication is started before cerebral oxymetry is established * patients with known neurological disease * patients with undergone cerebral insult, transient ischemic attack or carotid stenosis * patients who have been resuscitated after cardiac arrest in connection with this hospital stay * patients with a body temperature below 35 degrees celsius when establishing monitoring

Keywords: septic shock cerebral oximetry vasopressor norepinephrine