Kornimate/medical-research-clean huggingface dataset:
development and validation of a large language model-based myopia assistant system

Conditions: Myopia; Large Language Model

Summary: myopia is a rapidly growing global health concern, and there is an urgent need for advanced tools that can facilitate personalized healthcare strategies. artificial intelligence (ai)-based solutions, such as large language models, offer robust tools for ophthalmic healthcare. in this study, investigators aim to validate a patient-centered large language model (llm)-based myopia assistant system with the following key objectives: 1) evaluate the ability of the llm models to generate high-level reports and help self-evaluation of myopia for patients in primary care; 2) evaluate its performance in answering evidence-based medicine-oriented questions and improving overall satisfaction within clinics for myopic patients.

myopia is a rapidly growing global health concern particularly affecting children and adolescents. the progression of myopia can lead to severe complications such as myopic macular degeneration, significantly impacting visual acuity and quality of life. with the rising prevalence of myopia, there is an urgent need for advanced tools that can facilitate personalized healthcare strategies. artificial intelligence (ai)-based solutions, such as large language models, offer robust tools for ophthalmic healthcare. nevertheless, their effectiveness and safety in real clinical environments have not been fully explored. in this study, investigators aim to validate a patient-centered large language model (llm)-based myopia assistant system with the following key objectives: 1) evaluate the ability of the llm models to generate high-level reports and help self-evaluation of myopia for patients in primary care; 2) evaluate its performance in answering evidence-based medicine-oriented questions and improving overall satisfaction within clinics for myopic patients. the findings of this study will provide valuable insights for the application of the gpt model in the healthcare field, making a significant contribution to improving the accessibility and quality of medical services.

Eligibility criteria:
inclusion criteria: 1. outpatient participants aged 6 to 75. 2. participants who undergo ophthalmic examinations for medical purposes. 3. participants who can produce clear ophthalmic images in both eyes. 4. no prior experience in research involving digital medicine 5. agree to participate in this study with written informed consent exclusion criteria: 1. participants who are reluctant to participate in this study 2. participants who are unable to understand the study. 3. participants who have recently undergone ocular surgery or those with severe ocular conditions that may affect the interpretation of imaging results related to myopia evaluation (e.g., severe vitreous hemorrhage, cataracts, corneal leukoma, etc.) will be excluded from the study. 4. participants with poor quality of ophthalmic images, including blurriness, artifacts, underexposure, or overexposure. 5. other unsuitable reasons determined by the evaluators.

Keywords: myopia large language model assistance
the remote monitoring of gout feasibility study

Conditions: Gout

Summary: in this feasibility trial, a digital follow-up treatment strategy with patient self-management app (urika) and remote monitoring in specialist healthcare for patients with gout will be tested.

in this feasibility study various outcome measures will be assessed to determine whether the app (urika) is viable, practical, and useful. the study will include assessments of technical, operational, clinical, and trial aspects of feasibility.

Eligibility criteria:
inclusion criteria: * male or non-pregnant, non-nursing female \>18 years of age at screening * patients with a clinical diagnosis of gout * patients who fulfil the american college of rheumatology (acr)/eular classification criteria * serum urate level \>360 μmol/l at inclusion * having a smartphone/tablet exclusion criteria: * contraindication for urate lowering therapy * unstable medical conditions (e.g,, uncontrollable hypertension, impaired liver function); known stage 3b or higher chronic kidney disease (estimated glomerular filtration (egfr) rate/creatinine clearance \<45 ml/min); severe infection or gastrointestinal bleed * major co-morbidities (e.g., malignancies, severe cardiovascular disease, severe diabetes mellitus, severe respiratory diseases) * psychiatric or mental disorders, alcohol abuse or other substance abuse, language barriers or other factors which makes adherence to the study protocol difficult
novellusdx tissue collection protocol

Conditions: Patients That Have Been Diagnosed With Colorectal Cancer; Patients Eligible for Tumor Biopsy

Summary: novellusdx is developing a diagnostic platform for the personalized cancer therapy based on patient derived tumor tissue. the assay is able to sense activating mutations by monitoring their effect on a chip-based device.


Eligibility criteria:
inclusion criteria: * patients that have been diagnosed positive for colon cancer. * available treatment follow up during cancer treatment exclusion criteria: * none
impact of ibis on patients with advanced copd

Conditions: COPD

Summary: the purpose of this research is to determine if ibis™, a digital therapeutics solution developed by senscio systems, reduces the emergency room visits and hospitalizations of patients with copd.


Eligibility criteria:
inclusion criteria: * gold stage ii with a cat score above 19 * gold stage iii/iv with a cat score above 14 exclusion criteria: * cognitive or physical impediments that inhibits patients from interacting with our digital therapeutics platform.
to assess the role of fecal microbiota transplant in acute liver failure

Conditions: Acute Liver Failure

Summary: all patients of acute liver failure not meeting the kch (king's college hospital) criteria/or meeting kch criteria not having option of liver transplant will be recruited for the trial. the first group will receive standard medical care with fecal microbiota transplant on day 1 for 3 consecutive days. fmt (fecal microbiota transplant) will be delivered rectally which will be placed bedside. suitable donor will be screened and the stool samples will be used as per criteria. stool samples will be taken at the time at day 0, 1(post fmt), day 4, 6, 14,21. sepsis screen will be sent. inflammatory markers will be sent on day 0,1, 4,6, 14,21. the second group will receive standard medical therapy/and an placebo. stool samples will be sent on day 0,1, 4, 6 , 14,21. inflammatory markers will be sent on the time on day 0,1 4,6 , 14,21.


Eligibility criteria:
inclusion criteria: acute liver failure -not meeting kch criteria/meeting kch criteria but not having liver transplant option exclusion criteria: 1. culture positive sepsis 2. history of taking lactulose, rifaximin, neomycin, metronidazole, l-ornithine l-aspartate 3. receiving psychoactive drugs, promotility and hypomotility drugs 4. pregnant females
bioavailability study of sparc001(study 1) in healthy adult volunteers

Conditions: Healthy

Summary: the objective of the study is to determine the relative bioavailability, safety and tolerability of sparc001 and reference001 in healthy, adult, male and female subjects


Eligibility criteria:
inclusion criteria: 1. adult, male and female volunteers, 18 to 55 years of age, inclusive, at first check-in visit; 2. body mass index (bmi) ≥18 to ≤30 kg/m2 and total body weight \>50 kg (110 lbs) at screening 3. all female subjects must have a negative serum pregnancy test at screening and at each check-in visit 4. medically healthy on the basis of medical history exclusion criteria: 1. females who are pregnant, lactating, or likely to become pregnant during the study 2. life-time history and/or recent evidence of alcohol or drug/substance abuse disorder 3. subjects with history or presence of significant cardiovascular, pulmonary, hepatic, gallbladder or biliary tract, renal, hematologic, gastrointestinal, endocrine, immunologic, dermatologic, neurologic, psychiatric disease, or active sexually transmitted disease 4. subjects determined by the investigator to have any medical condition that could jeopardize their health or prejudice the results
endovascular denervation in patients with cancer pain

Conditions: Cancer Pain

Summary: endovascular arterial denervation (ed) is a minimally invasive technique which could reduce the occurrence of injury of visceral tissue or organs. as the principle of renal denervation (rdn), radiofrequency energy delivered by a multi-electrode catheter to the celiac plexus over the anterolateral surface of the superior mesenteric artery (sma) and the celiac axis. damaged or partially damaged celiac plexus can achieve the effect of pain relief.

the multi-electrode catheter was consisted of six independent electrodes helically on a net structure, which could be set as the same energy and temperature for simultaneous multi-point ablation. a real-time monitoring capability also provided by the display.

Eligibility criteria:
inclusion criteria: * 25 to 75 years * severe cancer pain with the visual analogue scores of no less than 7 exclusion criteria: * pregnant or intent to become pregnant within 1 year * postural hypotension * uncorrected coagulation dysfunction * aortic aneurysm or dissection * type 1 diabetes mellitus (t1dm) * acute or severe systemic infection * history of cerebral apoplexy or transient ischemic attack (tia) in the past two weeks * history of acute coronary syndrome in the past two weeks * participants who are not suitable to be enrolled into the study assessed by the researchers
predictive value of coronary heart disease (chd) biomarkers for chd death

Conditions: Cardiovascular Disease

Summary: the overall objective of this research proposal is to determine whether the predictive value of using plasma concentrations of selected nutrient biomarkers of food intake determined using a single plasma sample either alone or in combination are stronger, objective predictors of subsequent death from coronary heart disease (chd) or myocardial infarct (mi) compared to selected food intake data derived from subjective, self-reported food frequency questionnaires.

the overall objective is to determine whether the predictive value of plasma concentrations of selected nutrient biomarker(s) of food intake determined using a single plasma sample either alone or in combination are stronger, objective predictors of subsequent death from chd or mi compared to selected food intake data derived from subjective, self-reported food frequency questionnaires. the nutrient biomarkers (phospholipid \[pl\] eicosapentaenoic acid \[epa\], pl docosahexaenoic acid \[dha\], pl trans fatty acids, phylloquinone, dihydrophylloquinone) and foods (fish, dark fish and tuna, vegetables, fruits, and whole grains, and unsaturated fat rich foods) targeted have previously been either directly or indirectly associated with cvd risk. we propose to test our overall objective by conducting a nested case-control study using plasma samples and food frequency data from the observational cohort of the women's health initiative (whi). our cases (n=1200) will be selected from the subset of women who did not report dietary supplement use and who died of chd or mi (collectively referred to as whi chd cases). the control subjects (n=1200) will be selected from the subset that were free of chd or mi events and matched with cases for standard national cholesterol education program (ncep) risk factors (whi controls). nutrient biomarker data will be newly generated using stored specimens whereas the selected food intake data have previously been collected by the whi investigators.

Eligibility criteria:
inclusion criteria: cases, defined as women with centrally confirmed chd and fatal or non-fatal myocardial infarction (mi). control subjects were matched on the basis of age, enrollment date, race/ethnicity and absence of chd, mi, angina, coronary artery by-pass graft/ percutaneous transluminal coronary angioplasty, congestive heart failure, stroke or peripheral vascular disease at baseline. exclusion criteria: none

Keywords: nutrient biomarkers food frequency questionnaire predictors of cvd fatty acids phylloquinone dihydrophylloquinone
the effect of indacaterol on exercise endurance in patients with moderate to severe chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study compared the effect of indacaterol (300 μg once daily \[od\]) on exercise endurance with that of placebo in patients with moderate to severe chronic obstructive pulmonary disease.


Eligibility criteria:
inclusion criteria: * male and female adults aged ≥ 40 years, who have signed an informed consent form prior to initiation of any study-related procedure. * co-operative outpatients with a diagnosis of moderate to severe chronic obstructive pulmonary disease (copd), as classified by the gold guidelines (2006), and: * smoking history of at least 20 pack years. * post-bronchodilator forced expiratory volume in 1 second (fev1) \< 80% and ≥ 30% of the predicted normal value. * post-bronchodilator fev1/forced vital capacity (fvc) \< 70%. exclusion criteria: * pregnant or nursing (lactating) women. * women of child-bearing potential. * patients who have been hospitalized for a copd exacerbation in the 6 weeks prior to screening or during the run-in period. * patients requiring oxygen therapy or who experience oxygen desaturation to \< 80% during cycle exercise on room air. * patients with a wmax value \< 20 w (as determined by the incremental cycle endurance test) at screening. * patients who have had a respiratory tract infection within 6 weeks prior to screening. * patients with contra-indications of cardiopulmonary exercise testing. * patients with concomitant pulmonary disease. * patients with a history (up to and including the screening visit) of asthma. * patients with diabetes type i or uncontrolled diabetes type ii. * any patient with lung cancer or a history of lung cancer. * any patient with active cancer or a history of cancer with less than 5 years disease free survival time. * patients with a history of long qt syndrome or whose qtc interval (bazett's) measured at the collection of informed consent visit (visit 1) or randomization is prolonged. * patients who have been vaccinated with live attenuated vaccines within 30 days prior to screening or during the run-in period. * patients unable to successfully use a dry powder inhaler device, metered dose inhaler (mdi), or perform spirometry measurements. other protocol-defined inclusion/exclusion criteria applied to the study.

Keywords: indacaterol chronic obstructive pulmonary disease exercise endurance moderate to severe chronic obstructive pulmonary disease copd
evaluation the effect of using of apical matrix with apexification procedure on apical healing of necrotic immature teeth

Conditions: Pulp Necrosis; Apexification

Summary: this study was conducted to evaluate the effect of the use of apical matrix, with mineral trioxide aggregate (mta) or calcium hydroxide ca(oh)2 apexification on apical healing and calcific barrier formation of immature teeth with non- vital pulp.

conventional root canal ﬁlling procedures are challenging in cases of teeth with necrotic pulp, immature apices, and periapical lesions because of the absence of natural apical constriction and the presence of moisture contamination. in these cases, the risk of extrusion of the root ﬁlling materials and the difﬁculty in managing apical seals compromise the long-term outcome of treatment. management of immature teeth with non-vital pulp were confined to custom fitting the filling material, paste fills and apical surgery. the limited success enjoyed by these procedures resulted in significant interest in the phenomenon of establishment of an apical barrier like apexification or continued apical development. apexification defined as a procedure to induce a calcified barrier in a root with an open apex and necrotic pulp traditionally, the most commonly used material for apexification is ca(oh)2 .despite the high success rate of the long-term ca(oh)2 apexification , there are several disadvantages to this technique; length of time for induction of apical hard tissue barriers. incomplete apical hard tissue barriers because of vascular inclusions.to avoid the challenges associated with long-term ca(oh)2 apexification procedures, a non-surgical, one-step apexification using mta as apical plug. the major problem in cases of a wide open apex is the need to limit the apexification material at the apex, thus avoiding the extrusion of a large amount of material into the periodontal tissue. the use of a matrix is advisable since its placement in the area of bone destruction provides a base on which the sealing material can be packed . this randomized controlled trial study was carried out to compare the clinical and radiographic outcome of ca(oh)2 and mta with or without internal matrix in non-vital immature maxillary incisors.

Eligibility criteria:
inclusion criteria: * immature permanent maxillary anterior teeth * non vital pulp * 6-18 years old * half or more root length developed restorable * no internal or external root resorption * no horizontal or vertical root fractures * fit and healthy patient exclusion criteria: * mature * vital pulp * \ 18 years old * less than half of the root developed * non - restorable * root resorption * horizontal or vertical root fractures * patients with history of uncontrolled diabetes, immunosuppression, severe asthma patients suffering from periodontal disease

Keywords: open apex immature teeth non vital pulp apical plug internal matrix
video-debriefing for improved competence among skilled birth attendants in lira district-northern uganda

Conditions: Neonatal Encephalopathy; Helping Babies Breathe (HBB) Training

Summary: helping babies breathe (hbb) is a neonatal resuscitation training program for low-resource settings to health care workers to provide prompt respiratory support to save babies at birth. despite massive roll-out, new-born mortality reduction has stagnated over the years. innovative teaching methods with existing technology such as video-debriefing needs to be tested to promote competence (skills and knowledge) attainment and retention.

in this study we will randomize both public and private delivery facilities in lira district northern uganda to receive either standard hbb with video-debriefing (intervention) or standard training alone (control). we hope video-debriefing will improve competence among the health workers and promote skills and knowledge retention over time, hence reduction in neonatal mortality. the result of the study may also contribute to shaping refresher training program policy in low-resource settings.

Eligibility criteria:
inclusion criteria: * all health care workers attending to delivery and new-born care in both public and private facilities in lira district. exclusion criteria: * those who turn up for training just for daily allowances, having been sent by their facility in-charges to fill gaps such as community vaccinators, village health teams (vhts), security officers, cleaners, and laboratory technicians

Keywords: hbb knowledge and skills attainment and retention video-debriefing skills, knowledge, birth attendants
the safety and performence of shockpulse-10 in patients with coronary artery calcification

Conditions: Coronary Arterial Disease (CAD); Calcification; Heart

Summary: this study is an exploratory, multicenter, single-group clinical trial aimed to evaluate the clinical outcomes of using shockpulse-10 in the treatment of coronary artery calcification .

the study will be conducted at 8 sites in china and up to 205 participants will be followed for 180 days post procedure. patients ≥18 years of age scheduled for stent procedure with evidence of significant calcified stenosis of left main, or left anterior descending, right coronary artery or left circumflex will be eligible to enroll in the study. the primary endpoint of the study will evaluate procedure success,procedure success defined as successful stent implantation, residual stenosis degree ≤30% , and no major adverse cardiac events (mace) occurring during hospitalization.

Eligibility criteria:
key inclusion criteria: 1. patient is ≥ 18 years of age; 2. patients with significant coronary artery disease (including stable or unstable angina and asymptomatic myocardial ischemia) who are suitable for pci treatment; 3. a single newly developed stenosis of the target vessel, which is the left anterior descending artery, right coronary artery, or circumflex artery (or its branches), with stenosis degree ≥70% or ≥50% (visually inspect ) and accompanied by evidence of ischemia; 4. the target lesion is a primary, in situ coronary artery lesion; 5. the reference vessel diameter for the target lesion is 2.0-4.0mm, and the length of the target lesion is ≤40mm (visually inspect); 6. visual assessment indicates that the lesion site can accommodate the passage of a pre-dilator or trial instrument through the lesion; 7. the target lesion site has moderate to severe calcification (meeting one of the following conditions)： ① angiography: moderate calcification :clearer and more easily visible high-density shadows during cardiac pulsation; severe calcification :clear high-density shadows both during and at rest; ② ivus calcium score ≥2 points for superficial intimal, deep medial, and mixed calcification; 8. timi grade 3 in target vessel before registration (pre-dilation is allowed); key exclusion criteria: 1. left ventricular ejection fraction \< 40%； 2. nyha class iii or iv heart failure； 3. patients with single coronary artery supply; 4. patients with evidence of dissection at the site of the lesion on imaging; 5. the imaging suggests that the vascular pathway is tortuous, making it difficult for the pre-dilatation device to reach the target location or to be retrieved; 6. patients with active systemic infections; 7. patients with uncontrollable severe hypertension (systolic pressure \> 180 mmhg or diastolic pressure \> 110 mmhg); 8. patients with coagulopathy, hypercoagulable state or significant bleeding tendency (hemoglobin \<10g/dl or platelet count \<80×10\^9/l);
telerehabilitation in patients with pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: patients with pulmonary hypertension will be randomized into two groups. one group will receive telerehabilitation sessions including upper and lower extremity strengthening exercises and breathing exercises. the other will me monitored routinely. patients will be assessed by 6 minute walk test, emphasis-10 questionnaire for quality of life and muscle strength with hand-held dynamometer.


Eligibility criteria:
inclusion criteria: * patients with pulmonary hypertension exclusion criteria: * patients with severe exercise intolerance * patients with musculoskeletal problems that hinder exercise * patients who refuse to join the study
bioequivalency study of levetiracetam 1g under fasted conditions

Conditions: Seizures

Summary: the objective of this study was to prove the bioequivalence of levetiracetam 1000 mg tablets under fasted conditions


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. treatment with known enzyme altering drugs. history of allergic or adverse response to levetiracetam or any comparable or similar product.