Kornimate/medical-research-clean huggingface dataset:
electro-acupuncture to treat disorder of consciousness

Conditions: Disorder of Consciousness; Electroacupuncture

Summary: with the rapid development of life support technology, more and more people can survive severe brain injury. some survivors regain consciousness after a period of coma, however, many patients develop prolonged disorders of consciousness (doc), which poses a therapeutic challenge for clinicians and a heavy burden for their families. the investigators design an electro-acupuncture to treat disorder of consciousness (acudoc) trial with the aim of validating the clinical effect of electroacupuncture in treating doc and exploring its therapeutic mechanisms by integrating eeg, neuroimaging, evoked potential tests, and behavioral assessments.

the acudoc trial is a single-center, prospective, triple masking, randomized, sham electroacupuncture-controlled study. a total of 50 adult patients with doc and 25 healthy subjects will be enrolled in the study . patients will be randomized into electroacupuncture (ea) group or sham ea group (1:1). all patients will receive ea or sham-ea treatment in the supine position at 9 am for 30 minutes once a day for consecutive 14 days and healthy subjects will receive no treatments. the primary objective is to determine the therapeutic benefit of electroacupuncture on the recovery of consciousness in patients with doc after a 2-week intervention. key secondary objective is to investigate the effect of electroacupuncture on the circuitry of consciousness using a multimodal approach integrating eeg, neuroimaging (rs-fmri, amide proton transfer imaging, intravoxel incoherent motion imaging, neurite orientation dispersion and density imaging), and evoked potentials (sep, baep). other secondary outcomes include the effect of ea on the assessment of brain-computer interface after a 2-week intervention and on the glasgow outcome scale-extended score at 30 days and 90 days .

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years; 2. with cerebral damage due to tbi； 3. diagnosed with uws or mcs based on at least two crs-r assessments; 4. from 4 to 16 weeks from the onset of brain injury; 5. informed consent obtained. exclusion criteria: 1. with a history of neurological or psychiatric disorder prior to the brain injury; 2. with uncontrolled seizures or status epilepticus; 3. unstable vital signs and requiring the use of vasoactive agents; 4. with the use of general anesthetics or central acting sedative; 5. without intact skin at acupoints or sham points; 6. concomitant medical illness that would interfere with the outcome assessments and/or follow-up 7. pregnant patients; 8. currently participating in other investigational trials; 9. high likelihood of not adhering to the study treatment or the follow-up regimen

Keywords: acute brain injury disorder of consciousness electro-acupuncture awakening brain functional network
evaluation of the correlation between psychological intervention, including providing knowledge and tools for problems solving, and the anxiety level of female patients arriving to acth lrh test - pilot study

Conditions: Precocious Puberty

Summary: over 20% of the population is reporting on "white coat syndrome", manifested as anxiety symptoms and elevated bp during interaction with medical staff. it is estimated that, throughout the life span of children, approximately 15-20% will suffer from some form of a trauma relating to an interaction with health provider. the proposed study aims is to evaluate the correlation between a single preliminary psychological intervention, including providing knowledge and tools for problems solving, and the anxiety level in female patients arriving to adrenocorticotropic hormone (acth) and lutenising releasing hormone (lrh) test in comparison to the anxiety in patients arriving to the same test without psychological intervention. 20 female patients arriving to acth lrh test for puberty stage assessment (performed as part of routine medical care) will be recruited to the study and will be randomized to one of 2 groups. participants in the intervention group (10 patients) will be required to arrive with their parents an hour prior to the test and will receive a preliminary psychological intervention. the control group will arrive to the acth lrh test on the scheduled time and will not receive psychological intervention


Eligibility criteria:
inclusion criteria: * girls referred to acth lrh or lrh test * age 7-12 years old * ability to answer questionnaire independently (hebrew language only) exclusion criteria: * mental disability * girls who were referred to the test in purpose of evaluation of the pituitary adrenal axis after prolong steroids therapy. * girls with chronic disease that required frequent hospitalization (over 4 times per year)

Keywords: acth lrh test
research on the role of slc1a5 in the development of esophageal cancer

Conditions: Esophageal Cancer; Amino Acid Transport Disorder

Summary: to explore the significance of solute carrier family 1 member 5 (slc1a5) in the occurrence of esophageal cancer, by comparing the expression of slc1a5 between esophageal cancer tissues and adjacent tissues.

this will be an observational study. the investigators will aim to enroll 100 male and female adult patients (aged 18 years and over) of all ethnicities/races, who have been referred to the fourth affiliated hospital of guangxi medical university for esophageal cancer. the investigators will be using a standardized data collection form. this is an observational study in which standard of care will be practiced and the patients are not placed at additional risk from participating in this study. however, as the investigators are collecting data prospectively, all participants will sign consent. an attempt will be made to see if there is a correlation between the expression of slc1a5 with esophageal cancer.

Eligibility criteria:
inclusion criteria: 1. patients with histologically proven esophageal cancer; 2. age ≥18 years; 3. all patients must sign consent forms voluntarily; exclusion criteria: 1. inability to obtain histologic proof of malignancy. 2. age \<18 years;

Keywords: esophageal cancer slc1a5
efficacy and safety of nvc-422 in the treatment of adenoviral conjunctivitis

Conditions: Adenoviral Conjunctivitis

Summary: the purpose of this study is to evaluate the clinical and microbiological efficacy and safety of nvc-422 compared to vehicle for adenoviral conjunctivitis. adults and children one year of age and older with diagnosis of adenoviral conjunctivitis in at least one eye based upon a positive adenovirus test result using the aden-detactor plus kit (rapid pathogen screening, inc). subjects will be randomly assigned to receive either nvc-422 or vehicle.

this is a randomized (1:1) double-masked, vehicle-controlled, multi-center, parallel group study with two treatment arms: nvc-422 ophthalmic solution 0.33% ("nvc-422") and nvc-422 vehicle ("vehicle"). subjects that meet all inclusion/exclusion criteria will be enrolled into the study, randomized and evaluated at 6 visits: * visit 1: screening, day 1 * visit 2: day 3 * visit 3: day 6 * visit 4: day 11 end of treatment (eot) * visit 5: day 18 test-of-cure (toc) * visit 6: day 42 follow-up subjects were dosed ou for 10 days. specimens were collected ou at each visit for quantitative pcr adenoviral load and molecular typing.

Eligibility criteria:
inclusion criteria: * signs and symptoms of viral conjunctivitis in at least one eye for 3 days or less * bulbar conjunctival injection * other inclusion criteria per protocol exclusion criteria: * presence of subepithelial infiltrates (seis) at the day 1 visit in either eye * a suspected bacterial, fungal, herpes, chlamydia or acanthamoeba co-infection, based on clinical observation * other exclusion criteria per protocol

Keywords: adenovirus conjunctivitis pinkeye
factorial trial investigating outcome and adherence relevant factors in an online self-help intervention for depression

Conditions: Depression Mild; Depression Moderate

Summary: a vast amount of studies show that online interventions are suitable to reduce symptoms of mental illness as for instance depression or anxiety. however, participants who use online interventions are more likely to drop out of treatment compared to face-to-face interventions. it is important to enhance adherence to online interventions so that participants engage longer in the programs. also, as online interventions are useful to reduce the burden of mental illness, it is of interest to further improve outcomes of such interventions. therefore, it will be investigated in this study whether or not four different factors have an impact in fostering adherence to and improving outcome of an internet-based self-help intervention based on problem-solving therapy. a multifactorial design will be used for this study to screen simultaneously whether or not i) a diagnostic telephone interview and, ii) an educational module based on motivational interviewing prior to the intervention and iii) guidance by the study team, and iv) automated e-mail reminders during the study are active factors in enhancing adherence to and outcome of online interventions.


Eligibility criteria:
inclusion criteria: * phq-9-score between 5 - 14 * signed informed consent * contact information provided in case of emergency * internet connection and device to use it (smartphone, computer, tablet) * fluent in german language exclusion criteria: * suicidal tendencies (sbq-r \> 7) * a current or previous diagnose of a bipolar or psychotic disorder * a current diagnosis of severe depression or another psychological disorder
study of lonafarnib in combination with paclitaxel and carboplatin in patients with non-small cell lung cancer (study p01901)(terminated)

Conditions: Carcinoma, Non-small-cell Lung; Metastases, Neoplasm

Summary: the purpose of this study is to determine the overall survival of patients diagnosed with stage 3b or 4 non-small cell lung cancer (nsclc) treated with an oral farnesyl protein transferase inhibitor (lonafarnib/sch 66336) in combination with paclitaxel and carboplatin with that of patients treated with placebo in combination with paclitaxel and carboplatin.


Eligibility criteria:
inclusion criteria: * male or female * histologically or cytologically 3b or 4 (metastatic) non-small cell lung cancer. patients must meet any subcriteria as detailed in the protocol. * age greater than or equal to 18 years old * ecog performance status of 0 to 1 * prior diagnosis of brain metastases from nsclc eligible provided that the brain metastases have been adequately treated, patient is neurologically stable and no new or progressive brain metastases identified. * meets protocol requirements for specified laboratory values * written informed consent * appropriate use of effective contraception if of childbearing potential * prior basal cell carcinoma or carcinoma in-situ of the cervix are eligible provided they have been treated with no evidence of disease exclusion criteria: * prior chemotherapy for any stage of nsclc * prior surgery or radiation therapy within the last 2 weeks or incomplete recovery from prior procedures or therapy * concurrent treatment or treatment within the last 2 years for any other malignancy * grade 2 or greater nausea or grade 1 or greater vomiting (despite antiemetic medication) * medical conditions that would interfere with taking oral medications * patients with bone metastases as the only site of disease * pregnant or nursing women * known hiv positivity or aids-related illness * patients with significant qtc prolongation at baseline

Keywords: stage 3b or 4 (metastatic) non-small cell lung cancer
ultrasound imaging of kidney stones and lithotripsy

Conditions: Kidney Stones; Nephrolithiasis; Urolithiasis; Ureter Stones

Summary: the purpose of this study is to determine whether new software processing of ultrasound images can improve detection and size determination of kidney stones.

the purpose of our research is to improve the ability to see kidney stones with ultrasound imaging. specifically, we are testing how well new stone specific processing can find stones and show their size. ultimately, better imaging can improve the care of future patients. patients with kidney stones or undergoing surgery for kidney stones will be recruited and consented. we will image the kidney and ureter stones of consented subjects. we will place a water-based gel and ultrasound probe against the subject's skin on the back, sides, and abdomen. we will save the images and the raw electrical signals received from the probe and used to make the images. the images will be used to estimate the location and size of kidney stones in the kidney or ureter. the size and location will also be determined from x-ray and ultrasound images and reports already in the subject's medical record. and for recruited subjects who are already undergoing surgery in an existing clinical not research procedure, the surgeon will also measure location and size of stones seen in surgery. all these measurements of size and location of kidney stones will be compared to test the accuracy of the new ultrasound image processing. after the examination, we will not ask anything more of subjects, but we will collect some information from their existing medical records. this information includes existing images of your stones, size of stones, location of stones, number of stones, type of stones, and treatment records. we will also record your weight, height, race, and ethnicity. not all this information may be available. we will use what information is available. this additional information is used to test how well our ultrasound exam did. it also shows if we do better with certain groups of patients, for example, for certain stone types or body sizes.

Eligibility criteria:
inclusion criteria: * patients with kidney stones that are visible on x-ray (i.e., calcium stones) * current ct scan within the 90-day pre-operative period * able to give informed consent * age 21 years or older exclusion criteria: * inability to give informed consent * age less than 21 years * stones not visible on x-ray * patients with systemic disease or renal anatomical disorders (rta, primary hyperparathyroidism, sarcoidosis, enteric hyperoxaluria, medullary sponge kidney)

Keywords: kidney stones ultrasound imaging ureter stones
characteristics of women with reproductive concerns

Conditions: Endocrine Disorders of Female Reproductive System

Summary: the purpose of this study is to collect data that will be generated during an office visit. the data will be gathered and analyzed in research studies that will help with the investigators understanding of various medical conditions. about 200 subjects will be participating in this study. participation in this study will not require a patient's time or presence. the medical information contained in a patient's chart from the office visit, including the results of any tests that were ordered at that time, will be transferred to an anonymous database and analyzed together with data from other patients who have similar condition/s. no follow-up information will be collected. the following information will be collected from a patient's medical record: the medical history and a list of the current medications.

purpose: to collect the characteristics of patients presenting to the reproductive endocrinology clinic. rationale: patients' characteristics will be analyzed as part of clinical research studies and may help in understanding the causes of their condition.

Eligibility criteria:
inclusion criteria: * females of childbearing potential experiencing reproductive endocrinology related problems exclusion criteria: * male or female not of childbearing potential
thrombosed external hemorrhoids: comparison of the thrombectomy and local excision procedures in terms of results and outcome (teh)

Conditions: Thrombosed External Hemorrhoid

Summary: the primary aim of the current study is to evaluate and compare 6-month complication rates after thrombectomy and local excision treatments. the investigators aim to compare thrombectomy and local excision treatments in many different aspects: * the investigators will follow these patients for 6 months by scheduling follow-up visits (or by phone if the patient cannot attend) 4 times during this period (1st week, 1st month, 3rd month, 6th month). * the investigators will examine bleeding, pain, anal stricture/stenosis, infection, time until return to normal daily activity, relapse and incontinence after treatment * to assess quality of life outcomes, the investigators use the 36-item short form health survey (sf-36). these measures rely upon patient self-reporting and are utilized for routine monitoring and assessment of care outcomes in patients. * the investigators will use the wexner incontinence score for assessment of incontinence. in each hospital, medical students, residents and surgeons can be involved in the study. in the following 6-month period, all collaborators will be collecting the data of the patients who have been operated for external hemorrhoids via the thrombectomy or local excision procedures.


Eligibility criteria:
inclusion criteria: * patients who are diagnosis with thrombosed external hemorrhoids. * providing a written informed consent form for the surgeries and for participation in the study * patients aged 18 years and over should be included exclusion criteria: * patients younger than 18 years of age, * pregnancy * patients who have a history of cancer or inflammatory bowel disease(ibd) * patients who have a history of anorectal fistula * patients with metabolic disorders * patients with alcohol or substance addiction * patients who refuse to participate in the study and do not provide informed consent * patients who, at any stage of the study, indicate that they want to leave the study.
study of gut microbiota in crohn's disease patients suffering from spondylarthritis

Conditions: Crohn Disease; Spondyloarthritis

Summary: the floracrohn project aims to compare gut microbiota of patients suffering from crohn's disease (cd) associated or not to spondylarthritis (spa). 3 groups of patients will be analyzed: patients suffering from cd alone, patients suffering from spa alone, patients suffering from cd and spa. fecal microbiota will be determined by 16srna gene sequencing.


Eligibility criteria:
inclusion criteria: * patients with crohn's disease and axial spondyloarthritis according to the criteria below. * patients with crohn's disease (ct patients) diagnosed according to clinical, biological, radiological, endoscopic and / or histological criteria for 3 months. with diagnosis of spondyloarthritis exclusion on modified asas and / or new york criteria. * patients with axial spondyloarthritis (spa patients) diagnosed according to the modified asas and / or new york criteria with exclusion diagnosis of crohn's disease. * patient with the capacity to give free and informed consent. exclusion criteria: antecedent of colonic resection * antibiotic or colonic colonoscopy preparation in the 8 weeks prior to stool collection (against temporary indication = collection possible before colic preparation or on the first saddle after the start of the colic preparation). * ostomy at time of collection * bmi\> 30 * extreme diet * unbalanced diabetes * patient under guardianship, under curatorship or under safeguard of justice
a study of gzr18 injection in chinese obese/overweight patients

Conditions: Obesity; Overweight

Summary: the study was a multicenter, randomized, double-blind, placebo-controlled phase ib/iia clinical study to evaluate the safety, tolerability, pharmacokinetics and efficacy of gzr18 injection in chinese adult obese/overweight patients. this study is divided into part a and part b, which are to be conducted simultaneously.


Eligibility criteria:
inclusion criteria: * 1. male or female aged 18-65 years (inclusive); 2. obese subjects: bmi ≥ 28.0 kg/m2; or overweight subjects: 24.0 ≤ bmi \< 28.0 kg/m2 with at least one comorbidity; 3. able to understand the procedures and methods in this study; willing to complete the study in strict accordance with the clinical study protocol and sign the icf voluntarily. exclusion criteria: * 1. suspicion that the subject may be allergic to any study drug or ingredient or congener from the investigator. 2. subjects with body weight change \> 5.0% for any reason (diet, exercise, etc.) within 12 weeks prior to screening. 3. heart rate \ 100 beats/min on 12-lead ecg at screening. 4. presence of the following clinically significant 12-lead ecg abnormalities at screening. 5. alcohol abuse within 6 months prior to screening, or reluctance to stop alcohol abuse throughout the study, or a positive breath alcohol test result at screening.
social skills in children with autism spectrum disorders

Conditions: Pervasive Developmental Disorders

Summary: to evaluate whether a structured social skills program, called social skills development,is superior to a wait list control group on measures of interpersonal interaction. the social skills development (ssd) is a 16-week, group intervention that uses activities and peer tutors to promote interpersonal skills in children 8 to 11 years of age with autism spectrum disorders.following a diagnostic and social skills assessment,children are randomly assigned to ssd or wait list for 16 weeks. children who were randomized to the wait list are offered ssd at week 16. children randomized to ssd are followed for 9 months to assess the durability of gains during the first 16 weeks.

this project is designed to evaluate the acceptability and initial efficacy of a structured group treatment intervention for enhancing social behavior in 40 children with autism spectrum disorders (asds). an important long-term goal of this project was to develop a model for delivery of social skills training that could be tested in a larger trial and ultimately exported to schools and community settings. to accomplish these aims, we designed a randomized clinical trial to evaluate a structured social skills program for school age children with pervasive developmental disorders (pdds)compared to a wait list control group. specific aims included gathering preliminary evidence on the efficacy of the intervention on various parent measures of behavior, as well as an assessment of overall social functioning by an independent rater who would be blind to treatment assignment. the social skills development program uses semi-structured activities and peer tutors to promote interpersanal skills. to evaluate acceptability of the program, we planned to track attendance, attrition and parent satisfaction in the trial. finally, to evaluate the durability of gains achieved during the social skills development program, we re-assessed the subjects initially randomized to the active treatment group at 9 months post-treatment.

Eligibility criteria:
inclusion criteria: * 8 to 11 years * full scale iq score \> 70 * pdd diagnosis (autism, asperger's, pdd-not otherwise specified) exclusion criteria: * concurrent, untreated psychiatric disorder(such as anxiety, depression or conduct disorder)

Keywords: autism pervasive developmental disorders social skills intervention