Kornimate/medical-research-clean huggingface dataset:
familial b-cell lymphoproliferative disorders

Conditions: Lymphoproliferative Disorders; Premalignant; Monoclonal B-Cell Lymphocytosis; Chronic Lymphocytic Leukemia

Summary: this study investigates families with at least two cases of b-cell lymphoproliferative disorders (lpd), and evaluates the prevalence of lpd in families, the relationship between medical history, genetic factors, and the risk of familial lpd, and various clinical outcomes for these families in a multiethnic population of jews and arabs in israel.


Eligibility criteria:
inclusion criteria: * patient inclusion criteria: patients must have lpd and must have a family history of lpd. lpd patients who signed an informed consent to participate in the study. criteria for the inclusion of relatives of patients: relatives must be related by blood to lpd patients or unrelated (for control group). relatives who signed an informed consent to participate in the study. exclusion criteria: * pregnant women, special populations and those lacking judgment will not be included

Keywords: lymphoproliferative disorders chronic lymphocytic leukemia monoclonal b-cell lymphocytosis
system accuracy of bgm gl60

Conditions: Diabetes Mellitus

Summary: this study assesses the system accuracy a blood glucose monitoring systems pursuant to iso 15197

this study assesses the system accuracy ofthe blood glucose monitoring systems for personal use gl60 as outlined in din en iso 15197:2015.

Eligibility criteria:
inclusion criteria: * male or female patients with hypo-, eu- or hyperglycaemia * the written informed consent had to be signed * the volunteers must be older than 18 years * the volunteers have legal capacity and are able to understand meaning, nature and possible consequences of the procedures involved exclusion criteria: * pregnancy or lactation * acute or chronic diseases with the risk of aggravation by the measure * a current constitution that does not allow participating in the study * participation in another study or activity with the blood glucose measuring system evaluated in the present study * application of substances listed in appendix a of din en iso 15197:2015
a study of jnj-86974680 in participants with advanced non-small cell lung cancer

Conditions: Carcinoma, Non-small-Cell Lung

Summary: the purpose of this study is to determine a safe and tolerable dose(s) of jnj-86974680 for further research in combination with cetrelimab and radiation therapy.


Eligibility criteria:
inclusion criteria: * individuals with histologically or cytologically confirmed stage iiib-iv non-small cell lung cancer (nsclc) * part 1: nsclc with a known actionable genetic mutation (for example, epidermal growth factor receptor \[egfr\], anaplastic lymphoma kinase \[alk\], c-ros oncogene 1 \[ros1\], v-raf murine sarcoma viral oncogene homolog b1 \[braf\]) must have received all approved targeted therapies and have progressed * part 2: no targetable mutations (for example, egfr \[epidermal growth factor receptor\], alk \[anaplastic lymphoma kinase\], ros1\[c-ros oncogene 1\], and braf \[b-raf proto-oncogene, serine/threonine kinase\]) * part 1 and cohort a of part 2: must have been treated with (a) anti-programmed death protein 1 (anti-pd-1) or programmed cell death ligand 1 (pd-l1) therapy and (b) platinum-based chemotherapy * for cohort b of part 2: previously treated with anti-pd-1/pd-l1 therapy for metastatic disease as the prior line of therapy * for cohort c of part 2: treatment naïve * adequate organ function exclusion criteria: * active central nervous system (cns) disease involvement * active autoimmune disease * active infection * history of solid organ or hematologic stem cell transplantation
the sub-saharan africa regional partnership for mental health capacity building

Conditions: Depression

Summary: this is a 10-site cluster-randomized implementation science trial that compares two clinic-level implementation strategies to facilitate ongoing ministry of health efforts to scale up depression treatment within non-communicable diseases clinics in malawi. primary outcomes are clinical care indicators measured at the level of the visit (patient screened yes/no; depression treatment initiated if indicated yes/no; depression treatment algorithm followed at follow-up yes/no). secondary outcomes are patient health outcomes measured at the level of the participant.

this 10-site cluster-randomized implementation science trial compares the success of two clinic-level strategies in achieving high-quality integration of depression treatment into 10 non-communicable diseases (ncd) clinics in malawi. clinics are randomized 1:1 to one of two clinic-level implementation strategies: a basic strategy involving an internal coordinator, and an enhanced strategy combining the internal coordinator with an external quality assurance monitoring and supervision team. during a pre-randomization run-in period (months 1-5), all clinics receive the basic strategy. during a post-randomization intervention period (months 6-38), half of the clinics continue to receive the basic strategy and half receive the enhanced strategy. visit-level data (for primary outcomes) and participant enrollment and follow-up (for secondary outcomes) are collected from all 10 clinics during the run-in and intervention periods.

Eligibility criteria:
inclusion criteria: patients who meet the following eligibility criteria will be invited to participate: * ages 18-65 years (antidepressant treatment considerations differ for those \ 65 years, and these age groups are expected to be very rare in the target clinics), * current or new patient receiving care for either hypertension or diabetes from a participating ncd clinic * elevated depressive symptoms (phq-9 score ≥5) exclusion criteria: patients will be excluded if they have * a history of bipolar or psychotic disorder, or show emergent threat of self-harm.
robotic, laparoscopic and open gastrectomy compared on short and long term outcomes

Conditions: Gastric Cancer

Summary: the overall purpose is to develop and maintain a multi-institutional database comprising of information regarding surgical, clinical and oncological features of patients that will be treated for gastric cancer with robotic, laparoscopic or open approaches and subsequent follow-up. the main objective is to compare the three surgical arms on surgical and clinical outcomes, as well as on the oncological follow-up.

a review of the scientific literature, which was recently published by the imigastric study group, aimed to perform a more complete analysis of the current situation regarding performing minimally invasive surgery for gastric cancer. significant limitations were found in the analyzed studies, including: * small samples of patients, mostly low-quality comparative studies * selection bias in the comparison groups (e.g. stage, extent of lymphadenectomy) * absence of subgroup analysis in significant research fields * lack of information on the surgical techniques adopted a large prospective multicenter registry could thus be the optimal way to clarify the role of minimally invasive surgery for gastric cancer and permit the evaluation of its short and long-term effects. a working basis for analyzing outcomes of interest and obtaining directions for guidelines and future study developments can also be created. the following would be the main advantages of a large prospective multicenter registry: * achieving a large sample of patients * collecting multiple variables, allowing for the making of a comprehensive statistical report * standardizing the methodology to be adopted, thus increasing accuracy * bringing together the experiences of both east and west to discover shared points a prospective registry can become a powerful tool that can guide research in this field to new developments and pave the way for other investigational opportunities.

Eligibility criteria:
inclusion criteria: * histologically proven gastric cancer * preoperative staging work-up performed by upper endoscopy and/or endoscopic ultrasound, and ct scan and in accordance to international guidelines * early gastric cancer * advanced gastric cancer * patients treated with curative intent in accordance to international guidelines exclusion criteria: * distant metastases: peritoneal carcinomatosis, liver metastases, distant lymph node metastases, krukenberg tumors, involvement of other organs * patients with high operative risk as defined by the american society of anesthesiologists (asa) score \> 4 * history of previous abdominal surgery for gastric cancer * synchronous malignancy in other organs * palliative surgery

Keywords: minimally invasive surgery gastrectomy robotic surgery laparoscopic surgery laparoscopy robot-assisted robotic robotic gastrectomy laparoscopic gastrectomy minimally invasive gastrectomy
disease containment measures among older adults during the covid-19 pandemia

Conditions: Dementia; Cognitive Impairment; Depression, Anxiety; Loneliness

Summary: this study will examine which impact lockdown strategies intending to prevent the spread of covid-19 had on people with cognitive impairment and dementia. comprehensive data from two large health studies in norway, conducted before and after the covid-19 outbreak, will be linked with health register data on the use of health care services and medication. further, it will be conducted a survey addressing questions on social isolation and use of communicative technology, from march 2020 to january 2021. the knowledge gained from this study can improve the health care system's ability to respond more adequately to pandemics and other unforeseen events, so that the negative consequences for older adults with dementia and cognitive impairment can be reduced.

introduction: to prevent the spread of covid-19 societies around the world have implemented various levels of lockdown strategies. norway locked down major parts of the society from march 2020. specifically, this meant that public services were closed (e.g. most in-home healthcare services, day care centres, group exercise/gyms and services that offer physiotherapy, medical and psychological consultation). for people with cognitive impairment and dementia, social distancing and self-isolation may have limited the use of normal strategies (e.g., distraction, stimulation, and social interaction) that are routinely adopted to manage some of the dementia symptoms, such as neuropsychiatric symptoms. a lack of daily routines may change the clinical conditions of patients with dementia. worsening of preexisting and/or the onset of new neuropsychiatric symptoms may occur, in addition to a possible decline of cognitive and functional capacities aim: the overarching aim of this project is to provide decision makers with vital information to improve the healthcare of people with dementia and cognitive impairment in the context of an epidemic. method: we will use four data sources:1) the fourth wave of the trøndelag health study (hunt, hunt4 70+), 2) three national health registries (the norwegian patient registry (npr), the norwegian registry for primary health care (nrphc) and the norwegian prescription database (norpd)), 3) a postal questionnaire concerning social isolation during the covid-19 epidemic, and 4) the ageing in trøndelag study (ait), which is a follow-up of the hunt4 70+ study. with this linkage of cohort data and national health registry data, we can identify factors that may make people with cognitive impairment and dementia vulnerable to loss of healthcare services because of covid-19 and subsequently to negative health consequences.

Eligibility criteria:
inclusion criteria: * inhabitants living in the designated areas exclusion criteria: * none

Keywords: dementia pandemic health care services population study older adults depression
use of noninvasive brain stimulation in parkinson's disease

Conditions: Parkinson's Disease

Summary: the purpose of this research is to determine whether repetitive sessions of transcranial direct current stimulation (tdcs) to the prefrontal cortex can enhance the cognitive, affective and motor functioning of those with parkinson's disease. in this study we will compare active tdcs with sham tdcs. each subject will receive two consecutive weeks of stimulation (monday through friday). a battery of neuropsychological and affective tests will be administered throughout the duration of the study.

note that this study is a two-center study (the other center is beth israel deaconess medical center - pi - alvaro pascual-leone) \* further study details are provided by spaulding rehabilitation hospital.

Eligibility criteria:
inclusion criteria: * diagnosis of "probable" pd, defined by the presence of at least 2 out of 3 cardinal motor features of pd (resting tremor, rigidity, and bradykinesia, plus a sustained and significant response to dopaminergic treatment); * age 40 or over; * taking stable medications for at least 30 days exclusion criteria: * features suggestive of other causes of parkinsonism/ parkinson-plus syndromes; * history of deep brain stimulation or ablation surgery, mass brain lesions; * history of schizophrenia, schizoaffective disorder, other psychosis, bipolar illness, alcohol/drug abuse within the past year; * need for rapid clinical response due to conditions such as initiation, psychosis, or suicidality; * contraindications to tdcs\* * metal in the head * implanted brain medical devices * unstable medical conditions (eg. uncontrolled diabetes, uncompensated cardiac issues heart failure, pulmonary issues, or chronic obstructive pulmonary disease) * pregnancy

Keywords: parkinson transcranial direct current stimulation motor function cognitive function affective function
optimal dosing for low-dose aspirin chemoprophylaxis for vte following total joint arthroplasty

Conditions: Venous Thromboembolism

Summary: this research study is attempting to answer the question of whether 81 mg aspirin once daily is as effective as 81 mg aspirin twice daily in preventing blood clots after total joint replacement surgery.


Eligibility criteria:
inclusion criteria: * \> 18 years of age * planning to undergo a primary total hip or knee arthroplasty exclusion criteria: * high risk patients for vte as defined by: * history of venous thromboembolism * active malignancy * known pro thrombotic condition * bmi \> 40 * patients requiring anticoagulation for pre-existing conditions * patients with the contraindication for use of aspirin or nonsteroidal antiinflammatory drugs for reasons such as peptic ulcer disease, intolerance, others. * patients not fluent in the language of the informed consent form * prisoners * pregnancy * reported to have mental illness or belonging to a vulnerable population

Keywords: chemoprophylaxis hip surgery knee surgery
investigation of changes in lower limb muscles after cerebrovascular accident

Conditions: Cerebrovascular Accident

Summary: the aim of this study is to investigate lower limb muscles after cerebrovascular accident

the aim of this study is to define and differentiate the changes in mmt properties related to the alterations in muscle tone of the lower limb in first-ever chronic stroke patients by using a 3d free-hand ultrasonography (3dfus) technique in combination with an instrumented spasticity assessment (ipsa). in these chronic stroke patients, the spontaneous neurological recovery is stabilized

Eligibility criteria:
inclusion criteria: * definition of case population : o first ever stroke with spasticity of the lower limb. * definition of control : * first ever stroke without spasticity of the lower limb * healthy aged-matched subjects exclusion criteria: * musculoskeletal or neurological problems affecting the lower limb * presence of other neurological pathology that could lead to spasticity, ataxia, dystonia * cognitive problems that impede measurements * severe co-morbidities * peripheral spastic medication
prevention ambassadors: intervention to promote hiv service engagement in the networks of ssp clients

Conditions: HIV

Summary: hiv testing and service uptake are infrequent among people who use drugs (pwud) in the united states. in partnership with a community-based syringe service program (ssp), this project will develop the ssp-based "prevention ambassadors" (pa) intervention to promote hiv testing and service uptake among pwud via the secondary distribution (i.e., peer delivery) of hiv self-testing (hivst) kits with local hiv service information and referrals to hiv service navigation in the social networks of ssp clients (i.e., pwud). the pa intervention will then be piloted to assess its preliminary effects, acceptability, and feasibility among pwud in the ending the hiv epidemic priority jurisdiction of riverside county, california.


Eligibility criteria:
index participant inclusion criteria: * being greater than or equal to 18 years old * reporting drug use (past month) * having other people who use drugs (pwud) in one's social network * being willing to talk about hiv testing and services with at least 2 pwud in their networks and attempt to refer them to the study * speaking english fluently peer-recruit participant inclusion criteria: * being greater than or equal to 18 years old * reporting drug use (past 3 months) * being recruited by an index participant (evidenced by presenting the coupon used to recruit them) * speaking english fluently exclusion criteria: - persons who participated in formative study activities related to the development of the pa intervention will not be eligible to participate.
physical activity program on clinical output in heart failure

Conditions: Heart Failure; Nursing Caries

Summary: background: this study was carried out to determine the effect of physical activity program applied to individuals with heart failure on quality of life, functional capacity and mortality risk level. objective: the study, which was conducted as a randomized controlled experimental study, was completed with a total of 40 hf patients, 20 of whom were interventions and 20 were controls. a physical activity program lasting at least 30 minutes each session was applied to hf patients in the intervention group, three days a week for three months, and the walks of the patients were followed by a pedometer.

background: this study was carried out to determine the effect of physical activity program applied to individuals with heart failure on quality of life, functional capacity and mortality risk level. objective: the study, which was conducted as a randomized controlled experimental study, was completed with a total of 40 hf patients, 20 of whom were interventions and 20 were controls. a physical activity program lasting at least 30 minutes each session was applied to hf patients in the intervention group, three days a week for three months, and the walks of the patients were followed by a pedometer. at the same time, a monthly home visit and weekly phone call were made to the patients. no intervention was applied to the patients in the control group, apart from weekly phone calls. all patients were receiving optimal stable hf therapy.

Eligibility criteria:
inclusion criteria: * over 18 years of age, * class i, ii, iii according to nyha classification, * without any diagnosis of musculoskeletal deformity or disease that may prevent them from doing physical activity, * hypertension stage 1 and 2, * stable chronic disease processes such as diabetes, * patients whose treatment for these diagnoses has not been changed in the last month, * dyspnea status less than 4-5 degrees according to the modified borg scale, * cognitive competence, * at least primary school graduates exclusion criteria: * known and diagnosed moderate or severe mitral/aortic regurgitation, hypertrophic obstructive cardiomyopathy, uncontrollable arrhythmia (atrial fibrillation etc.), bundle branch block on ecg, * acute myocardial infarction in the last three months, * unstable angina pectoris, pacemaker, valve surgery, coronary artery bypass surgery history, newly diagnosed or suspected thromboembolic event, * diagnosed with cerebrovascular and peripheral vascular insufficiency, other chronic diseases (such as chronic obstructive pulmonary disease, chronic kidney failure, pulmonary emphysema, rheumatic valve disease, cancer diagnosis), * chronic fatigue syndrome

Keywords: heart failure physical activity functional capacity quality of life nt-probnp mortality risk level
ziptight or tricortical screw fixation of acute tibiofibular syndesmotic injury

Conditions: Ankle Fractures

Summary: treatment of syndesmotic injury with weber c fracture. a randomized study comparing ziptight suture endobutton and one tricortical 3,5 mm syndesmotic screw.

syndesmotic injuries are common and often associated with unstable ankle fractures. the most common treatment is with a syndesmotic screw through the fibula and tibia which is later removed, usually after 10-12 weeks. the ziptight suture endobutton (biomet) is used for the same indication. it does not need removal and thus avoids subsequent surgery. this trial will compare these two methods and see if they are equal. patients 18-70 years presenting to one of the three hospitals with and acute syndesmotic injury are eligible for inclusion. 120 patients are randomized to two treatment groups. one group will be treated with a ziptight suture endobutton fixation and the other receives a tricortical screw fixation. neither suture endobutton or screw is routinely removed. follow up intervals are at 6 weeks, 6, 12 and 24 months with clinical and-points. standardized ct scans are taken postoperatively and at 12 and 24 months.

Eligibility criteria:
inclusion criteria: * 18 to 70 years * acute syndesmotic injury with weber type c fracture exclusion criteria: * prior injury og the same ankle * severe injury of the same leg affecting rehabilitation * symptomatic osteoarthritis of same ankle * open injury * decubital injury affecting surgical site * dementia or unable to sign informed consent * neuropatic conditions affecting same leg

Keywords: syndesmosis injury ankle fracture weber c