Kornimate/medical-research-clean huggingface dataset:
human menopausal gonadotropin (hmg) vs recombinant follicle stimulating hormone (rfsh) in gonadotropin releasing hormone (gnrh) antagonist cycles

Conditions: Ovarian Stimulation

Summary: a randomized controlled trial comparing the ongoing pregnancy rate (primary end-point) in 280 patients undergoing ivf/icsi after stimulation with hp-hmg or rfsh controlled with a gnrh antagonist. non significant differences were observed between hp-hmg and rfsh in terms of the ongoing pregnancy rate per started cycle (35.0% vs. 32.1%; p=0.61); r.r: 1.09 (95% ci: 0.78-1.51; risk difference: 2.9%). no differences were observed for implantation, clinical pregnancy and pregnancy loss rates. patients receiving rfsh obtained more oocytes (14.4 ± 8.1 vs. 11.3 ± 6.0; p=0.001). estradiol was higher at the end of stimulation in the hp-hmg group, while progesterone was higher in patients stimulated with rfsh.


Eligibility criteria:
inclusion criteria: * women with good physical and mental health * aged 18-37 years * regular menstrual cycles ranging from 25 to 35 days; body mass index (bmi) \< 30 kg/m2 * normal basal serum fsh (≤ 10 iu/l) and e2 (≤ 75 pg/ml) levels determined on the day 3 of the cycle previous to coh * no uterine (fibroids, adenomyosis, mullerian malformations), ovarian (endometrioma, polycystic ovaries) or adnexa (hydrosalpinx) abnormalities assessed by vaginal ultrasound. exclusion criteria: * patients with a history of recurrent pregnancy loss * any significant systemic disease, endocrine or metabolic disorder * having concomitant medication interfering with the purposes of the study * patients who have received any ovulation induction drug within one month before their inclusion in the study.

Keywords: ongoing pregnancy rate
the impact of two strategies in the monitoring of exudative armd on the visual acuity (by oct b scan or oct angiography)

Conditions: Age-related Macular Degeneration

Summary: the treatment of neovascular age-related macular degeneration (armd) is a major issue of public health. the therapeutic arsenal has widely grown throughout the years with the emergence of intra-vitreous anti-angiogenic treatments, under different surveillance protocols. the "prn" surveillance (pro re nata: an on-demand treatment with monthly follow-up) allows a faster re-injection in case of neovascular relapse in order to maintain the best visual acuity. this therapeutic protocol is guided by the sub-retinal neovascular signs of activity. the monitoring is done during common practice via oct b scans showing indirect signs of neovascular activity (exudation signs). oct retinal imaging has been recently enriched with new programs allowing the visualization of sub-retinal neovessels without the use dyes (oct angiography). the oct angiography is automatically done by a program using standard oct sections. during the monitoring of a patient using the oct a, the signs of renewed neovascular activity are represented by an "arterialization" or the development of an arteriole network of the neovessel with the reappearance of a hyper reflective flow after a neovascular regressive phase. indeed, the visualization of neovessels during the monitoring by angio-oct may lead to therapeutical modifications (anticipation of the injections). knowing that the injection time-table of armd patients treated with anti-angiogenics is determined by sub-retinal neovascular signs of activity. this activity is evaluated during routine clinical practice by very specific signs, observable on oct b scans. the hypothesis of this study is that the search of activity sins on the angio-oct, a new technic of image analysis performed on the oct, may modify this injection time-table, with an impact of the patient's visual acuity.


Eligibility criteria:
inclusion criteria: * adult patient ≥ 50 years old * with exudative armd, * treated with intra-vitreous anti-angiogenics following a prn protocol (pro re nata) * absence of atrophy of the central pigment epithelium exclusion criteria * opposition to participate in this research * persons enjoying legal protection measure * lack of affiliation to social security and universal health coverage * pregnant or lactating * another cause of choroidal neovascularization * unbalanced glaucoma * eye surgery less than 3 months on the studied eye

Keywords: age-related macular degeneration optical coherence tomography angiography
effect of the lumbacure® intervention on elderly patients suffering from clbp.

Conditions: Low Back Pain

Summary: the goal of this investigation is to evaluate the safety and efficacy of the lumbacure® device in elderly people suffering from low back pain. the study is being carried out at several sites, in nursing homes, in order to reach the elderly patients most at risk of a sedentary lifestyle.


Eligibility criteria:
inclusion criteria: * chronic or sub-acute low back pain (without "red flag") * the subject, a resident or worker at the investigation site (nursing home), over 60 years of age * ability to communicate with the physiotherapist. * ability to remain in a sitting position for at least 10 minutes. * a level of back pain \> 2 on the numerical pain rating scale exclusion criteria: * suspected or confirmed serious pathology (infection, fracture, cancer, inflammatory arthritis, ....) related to the back/spine. * body weight \> 120 kg * subject is non-ambulatory or has severely reduced mobility. * dominant component of radicular pain (common lumbago with distal radiation below the knee) * radiculopathy * severe cardiorespiratory disease * dementia or significant cognitive impairment that prevents the participant from giving consent, completing study questionnaires or complying with recommendations. * fracture or operation less than 3 months old of the spine, pelvis, hip or leg bones. * known vertebral pathology other than osteoarthritis. * major neurological disease, movement or motor neuron disorders * fibromyalgia or other systemic rheumatic disease * recent history of stroke or heart failure, unstable heart condition * uncontrolled substance abuse disorders * invasive procedures to relieve pain in the last 3 months * acute or terminal illness * any other medical condition considered by the study team to be a contraindication to the study.
th17 inducing cytokines pregnancy and after postpartum

Conditions: Pregnancy

Summary: the aim of this study was to investigate salivary and gingival crevicular fluid (gcf) levels of il-17a, il-17e, il-6 and il-23 during 2/3 trimester of pregnancy and after delivery.

il-17 have a synergytic effect with il-6 and il-23. il-17a levels elevated with periodontal diseases. many systemical chronic conditions such as atherosclerosis and cardiovascular disease, pregnancy may contribute increasing of il-17 family cytokine.

Eligibility criteria:
inclusion criteria: * women 2 and 3 trimester of their pregnancy exclusion criteria: * any known systemic disease, * periodontal treatment within the last six months, * patients having less than 10 teeth, * smokers, * individuals with a bmi \> 30 kg/m2, * gestational diabetes and preeclampsia during pregnancy.

Keywords: periodontitis postpartum
impacts of oral irrigation in orthodontic patients

Conditions: Oral Hygiene; Orthodontics; Periodontal Diseases

Summary: the present study aimed to investigate clinically the cleaning effectiveness of different treatment modalities, that is, oral irrigator or interdental brush usage addition to routine brushing and examine interleukin (il)-1β, il-10, matrix metalloproteinase (mmp)-1, mmp-8 levels in gingival crevicular fluid of orthodontic patients. the null hypothesis was that oral irrigators would be effective compared to interdental brush in the oral care of individuals who are orthodontic patients.

the aim of this study is to compare the effectiveness of oral irrigator (oi) with interdental brush (ib) clinically and biochemically in orthodontic patients. thirty patients were randomly divided into two equal groups; patients using oi in addition to manuel brushing (oi-group), patients using ib in addition to manual brushing (ib-group). study was planned as randomized, single-blind, parallel-design. periodontal indexes were recorded clinically and interleukin (il)-1β, il-10, matrix metalloproteinase (mmp)-1, mmp-8 levels in gingival crevicular fluid were evaluated biochemically. after baseline examinations \[silness-löe plaque index(pi), löe-silness gingival index(gi), probing pocket depth(ppd), clinical attachment level(cal), bleeding on probing(bop)\], initial periodontal therapy was completed using full-mouth disinfection method. the data was collected in the baseline, 2nd, 4th and 8th weeks. the hypothesis of our study is that oral irrigators may be effective in oral care of orthodontic patients because of the ease of use.

Eligibility criteria:
inclusion criteria: * being over 12 years old. * having at least 20 permanent teeth with bands or brackets. * finished phase i periodontal treatment. * bleeding below 10% during probing. * no pocket depth of more than 5 mm. * not receiving any treatment other than orthodontic treatment during the study. * absence of removable or fixed prosthetic restorations. * absence of any systemic disease (hepatic, renal, hematologic, cardiovascular). * agreeing not to use any non-study mouthwash throughout the study. exclusion criteria: * performing poor cooperation. * having diseases associated with bacteriemia. * used antibiotics and anti-inflammatory drugs for any purpose for a long time. * having diabetes. * smoking habits. * having a physical or mental problem that affects manual dexterity. * using medication that could affect gingival health (such as dilantin, calcium channel blocker, cyclosporine, and anticoagulant).

Keywords: cytokine(s) matrix metalloproteinase(s) orthodontics oral hygiene
effect of power's program of gluteus maximus on lbp

Conditions: Low Back Pain

Summary: low back pain (lbp) is highly prevalent that causes significant pain and disability. core muscles are important for lbp. one of them is gluteus maximus, but effect of power's program for this muscle and its role in lbp is lacking in literature, so this study aims to study the effect of power's program of gluteus maximus on lbp.

chronic mechanical low back pain (cmlbp) is a common musculoskeletal dysfunction affecting 53% of egyptian population and 1.4 to 20.0% worldwide. which is a major social and economic burden. patients with cmlbp experience time loss of work and recently became a workforce burden. giving the fact that back pain is widely prevalent across egyptian population and by addressing the functional deficits in those patients, proper physical therapy intervention can help reducing such burden and improve over all work performance. the 'powers program' is a recent concept and it had been proven to be effective in improving lower extremity function and biomechanics. up to the knowledge of the primary investigator, gmax strengthening using this program has not been conducted in patients with cmlbp. studying this approach may benefit physical therapists by providing an evidence-based approach in treating patients with cmlbp through exercise therapy and improve functional performance of these patients therefore they can return to normal activities faster. moreover, this study may benefit researchers interested in gluteus maximus (gmax) muscle strength. we believe that this study may open up more rooms for future research to address such an important issue.

Eligibility criteria:
inclusion criteria * both sex. * age 21-45 years. * chronic mechanical liw back pain for more than 3 years. * body mass index 18.4-29.9 kg/m\^2. exclusion criteria * back pain due to specific pathology. * postoperative * trauma to lower quadrant with past 6 months. * radicular pain. lumbar instability.

Keywords: disability gluteus maximus low back pain power's program
perforator artery changes during suprafascial pre-expansion of the perforator flaps

Conditions: Scar; Contracture; Flap Disorder

Summary: tissue expansion methods have been recommended as a means of improving the clinical results with perforator flaps but in plastic surgery literature there are few clinical trials supporting this opinion. the purposes of this clinical study are to address the ''preexpanded perforator flap concept'' by demonstrating a case series of relevant reconstructive procedures and to evaluate the perforator vessel changes that happen during the expansion periods of various perforator flap donor sites.


Eligibility criteria:
inclusion criteria: * patients with broad scars and contracture bands * patients with esophagocutaneous fistula * patients with ambiguous genitalia exclusion criteria: * none

Keywords: scar contracture perforator flap preexpanded perforator flap perforator vessel artery diameter
kidney damage in patients with normal egfr

Conditions: Coronary Artery Stenosis

Summary: this is a pilot study, randomized, double-blind, parallel group comparison of two iodinated contrast agents used during percutaneous coronary intervention (pci). all patients enrolled must have normal egfr. statistical summaries will be presented to analyse the various laboratory tests for the two groups.


Eligibility criteria:
inclusion criteria: * provides written informed consent and is willing to comply with protocol requirements; * is at least 18 years of age; * is scheduled to undergo a percutaneous coronary intervention and/or diagnostic coronary angiography. * has documented estimated glomerular filtration rate \[egfr\] ≥60 ml/min/1.73 m2 calculated with the mdrd formula within 72 hours prior to enrollment. exclusion criteria: * is a pregnant or lactating female. * has a history of severe congestive heart failure * has a history of hyperthyroidism * has a history of hypersensitivity to iodinated contrast agents * has unstable renal function
randomized phase iii trial of adjuvant chemotherapy or chemoradiotherapy in resectable gastric cancer (critics)

Conditions: Gastric Cancer

Summary: the purpose of this study is to evaluate the efficacy and safety of combined chemotherapy and radiotherapy (in comparison to chemotherapy alone) as adjuvant treatment after surgery for gastric cancer. prior to surgery all patients will receive neo-adjuvant chemotherapy as well.

the mainstay of curative treatment of gastric cancer is radical surgical dissection. because most patients in the western world present with advanced stages long term survival is found in about 25%, with local recurrences as part of treatment failure in up to 80% of cases. studies examining the role of more extended lymph node dissections (d1 vs. d2), adjuvant radiotherapy or adjuvant chemotherapy did not result in a clinical relevant improvement of survival. in 2001 results of a south west oncology group (swog) trial that randomized between surgery and surgery with chemoradiotherapy were published. this trial, that was hampered by suboptimal surgery (less than d1 in majority of patients) and radiotherapy (2d radiotherapy; 35% protocol deviations) showed an absolute increase in median survival of 9 months. more recently results of the magic study, which randomized between surgery and surgery plus 6 perioperative courses of ecf chemotherapy, were presented. this regimen resulted in an absolute 5-year survival benefit of 13% and in a 10% higher resectability rate. this phase iii prospectively randomized study investigates whether chemoradiotherapy (45 gy in 5 weeks with daily cisplatin and capecitabine) after preoperative chemotherapy (3x ecc (epirubicin, cisplatin, capecitabine)) and adequate (d1+) surgery leads to improved survival in comparison with postoperative chemotherapy (3x ecc). furthermore, toxicity of both treatment regimens will be explored.

Eligibility criteria:
inclusion criteria: * ib-iva (no distant metastases) gastric cancer (histologically proven); tumor bulk in the stomach * who \< 2 * age ≥18 yrs * operable gastric cancer * no prior abdominal radiotherapy or chemotherapy * tumornegative laparoscopy when ct suggests peritoneal carcinomatosis * start treatment within 10 working days after registration * written informed consent exclusion criteria: * t1n0 disease (endoscopic ultrasound) * distant metastases * inoperable patients; due to technical surgery-related factors or general condition * previous malignancy, except adequately treated non-melanoma skin cancer or in-situ cancer of the cervix uteri. * solitary functioning kidney that will be within the radiation field * major surgery within 4 weeks prior to study treatment start, or lack of complete recovery from the effects of major surgery * uncontrolled (bacterial) infections * significant cardiac disorders * continuous use of immunosuppressive agents * concurrent use of the antiviral agent sorivudine or chemically related analogues * hearing loss \> ctc grade 1 * neurotoxicity \> ctc grade 1

Keywords: critics gastric cancer surgery adjuvant chemotherapy chemoradiotherapy capecitabine cisplatin epirubicin
effects of whey protein and collagen supplementation

Conditions: Exercise; Nutrition Therapy; Resistance Training; Muscle Strength; Hypertrophy

Summary: the present project aims to investigate the effects of high-quality protein (whey protein) vs. low-quality protein (collagen) on muscle mass and function (e.g., strength and power) during a 10-wk resistance training program in young adults. it will be tested the hypothesis that leucine-matched collagen should promote similar gains on muscle function and mass compared to whey protein supplementation.

the purpose of this study will be to investigate the effects of whey protein vs. leucine-matched collagen supplementation on muscle mass and function after a 10-wk resistance training program. initially, all participants will be submitted for a 2-wk familiarization period, and then randomized into two groups (n = 11 / group): whey protein group and leucine-matched collagen group. the following variables will be assessed from pre-to post-training: anthropometric, muscle thickness from vastus lateralis and biceps brachii muscles using ultrasound, training load, mean power and peak torque for unilateral arm flexion exercise using a isokinetic dynamometer, countermovement vertical jump, nutritional intake, and testosterone-to-cortisol ratio . shapiro-wilk and levine tests will be used to test the normality and homogeneity of the measurements, respectively. two-way anova (group x time) tests for repeated measures will be performed to assess changes over time and between groups for all dependent variables. violation of sphericity will adjust using greenhouse- geyser correction. the bonferroni post-hoc test will detect specific differences between groups. when appropriate, the percentage of change (∆%) will be reported according to the following equation: ∆% = \[(pre-average post average) / pre-average mean\] × 100. values will be express as mean ± standard deviation. o significance level α will be 0.05.

Eligibility criteria:
inclusion criteria: * men and women aged 18-35 years * to be eutrophic (not overweight or obese) exclusion criteria: * to present a history of musculoskeletal disorders * be attending a systematized weight training program for at least six months * to make use of medicines that could affect muscle function. * to have used ergogenic supplements and anabolic steroids for at least six months before study * to have restrictions for exercises practice considering physical activity readiness questionnaire (par-q) responses.

Keywords: protein supplementation amino acids resistance exercise muscle strength muscle hypertrophy
selenium supplementation of patients with cirrhosis

Conditions: Healthy; Liver Cirrhosis

Summary: the purpose of this study is to determine whether patients with liver disease can improve their nutritional selenium status by taking supplemental selenium.

selenium is an essential nutrient. selenium carries out its biological functions through selenoproteins. the most abundant selenoprotein in the plasma is selenoprotein p, which is largely synthesized in the liver. patients with liver disease often have less than half the selenoprotein p levels of normal individuals. this suggests that people with liver disease are not meeting their selenium requirements and may benefit from additional selenium. we proposed to compare the effects of two different forms of supplemental selenium on plasma selenium levels among patients with severe liver cirrhosis and healthy individuals (controls). patients and controls were randomly assigned to one of 3 treatment groups: 200 µg selenium per day as selenate, 200 µg selenium per day as selenomethionine, or a placebo. the intervention lasted 8 weeks. blood was measured initially and after 2 and 4 weeks of supplementation. selenium, selenoprotein p and glutathione peroxidase were measured in the plasma. we compared changes in selenium and selenoprotein levels between liver cirrhosis patients and healthy controls.

Eligibility criteria:
inclusion criteria: * healthy adults * adults with child-pugh class c liver cirrhosis exclusion criteria: * diagnosis of renal failure * urgent need of liver transplant * selenium supplements of \>25 µg per day during the past year
penetrating gunshot injuries at a single johannesburg centre

Conditions: Trauma

Summary: a retrospective audit of cardiac penetrating cardiac injuries with specific reference to gsw

a descriptive retrospective study looking at the outcomes in patients with penetrating cardiac injuries especially following gunshot injuries. the physiology on presentation, the iss, the rts, the clinical injuries confirmed, the type of investigations conducted, the length of hospital stay, the in-hospital mortality will all be collected. descriptive study statistics will be utilized and a p-value of \<0,05 will be considered statistically significant.

Eligibility criteria:
inclusion criteria: * all adult priority 1 patients with gsw cardiac injuries seen at a johannesburg trauma facility exclusion criteria: * incomplete data or dead on arrival

Keywords: cardiac penetrating gsw
surgical resection lowers oxidative stress markers in patients with colorectal cancer

Conditions: Colorectal Cancer; Colon Rectal Resection; Oxidative Stress

Summary: study of oxidative stress markers (f2 isoprostanes for lipid peroxidation, carbonyl groups for protein peroxidation, 3 nitrotyrosine for damage by nitrogens, and 8-hydroxyguanosine for rna peroxidation)in patients with colorectal cancer undergo surgical treatment (preoperatively during the intervention and postoperatively) and controls.

study of the impact of surgery on lipid peroxidation, protein peroxidation, damage by nitrogens, and rna peroxidation, in patients undergo surgical resection for colorectal cancer and compared with controls, and validation of the responsiveness of oxidative stress markers on surgery

Eligibility criteria:
inclusion criteria: * patients with colorectal cancer * controls exclusion criteria: * asa\>3 * metastatic disease * acute bowel obstruction * acute bowel perforation * bmi\<30 * chronic systemic or autoimmune diseases * smokers * alcohol consumers

Keywords: colorectal cancer surgical resection oxidative stress markers controls