Kornimate/medical-research-clean huggingface dataset:
evaluation of pathogenesis and diagnosis of mycoplasma pneumoniae community-acquired pneumonia (cap)

Conditions: Childhood Pneumonia; Mycoplasma Pneumonia; Antibody-secreting Cells; Enzyme-linked Immunospot (ELISpot); Diagnosis

Summary: to investigate the mycoplasma pneumoniae-specific circulating antibody-secreting cell (asc) response and mycoplasma pneumoniae-specific interferon (inf)-γ-secreting t cell response, along with polymerase chain reaction (pcr) and serology, in a cohort of children with community-acquired pneumonia (cap) and controls.


Eligibility criteria:
inclusion criteria: cap cohort: * children of age 3 to 18 years; * in- and outpatients; * clinically diagnosed community-acquired pneumonia (cap); healthy control cohort: - healthy asymptomatic children of age 3 to 18 years undergoing an elective surgical procedure; family control cohort: - family members of index cap patients. exclusion criteria: * hospital-acquired pneumonia; * immunodeficiencies; * chronic lung disorders.
radon asthma intervention trial

Conditions: Asthma

Summary: to determine if radon mitigation can improve asthma

we will conduct a randomized, double-blind, sham controlled trial to investigate the efficacy of radon mitigation in the homes of susceptible individuals to provide evidence for health benefits by improving indoor air quality. the trial will include 180 children with asthma. we will install a standard radon specific mitigation system in the participant's home. health outcomes will be followed over 48 weeks to determine the outcomes of the intervention versus inactive (sham) control.

Eligibility criteria:
1. have physician-diagnosed asthma at least 1 year prior to the screening visit 2. have evidence of uncontrolled disease as defined by at least one of the following: use of an asthma medication during the prior 12 months, report of asthma symptoms over the prior 12 months (wheezing/whistling in the chest)(3) or one or more asthma-related hospitalization, emergency room visit or unscheduled clinic or urgent care facility visit resulting in a burst of systemic steroids (3 days or more of prednisone or equivalent; 1 or more doses of dexamethasone) in the previous 12 months exclusion criteria 1. not residing at the household for at least 5 days a week or family planning to move from the current home within the next twelve months, or homes with active radon mitigation systems (if home uses a hepa filter air purifier, family must agree to disable the purifier for 28 days prior to randomization). 2. lung disease, other than asthma, that requires daily medication (inflammatory diseases, chronic lung diseases aside from asthma, congenital cardiopulmonary conditions requiring medication or surgical treatment), 3. homes with active hepa filters will be excluded (even though the role of hepa filters on radon and radon particles s is expected to be minimum and other exposures can be adjust for in the analysis) 4. cardiovascular disease that requires daily medication, excluding hypertension 5. taking a beta-blocker 6. currently receiving unstable level of immunotherapy (allergy shots) 7. coordinator/pi judgment 8. inability to perform lung function testing 9. intake of abuse drugs or alcohol, have psychiatric disorders or severe mental disability that interferes with answering questions or following instructions.
caudal block versus ultrasound guided ilioinguinal/iliohypogastric block in pediatric patient

Conditions: Surgery

Summary: the caudal block is the most common technique for inguinal surgery. increased use of ultrasound in regional analgesia techniques has been improved the practise of the peripheral nerve blocks. ilioinguinal and iliohypogastric nerve blocks are possible to alternative methods to the central blocks. the aim of this study is to compare analgesic efficiency of caudal block and ultrasound guided ilioinguinal and iliohypogastric nerve blocks for bilateral inguinal hernia in pediatric patients

in this prospective randomized study, pediatric patients between 1- 10 years old who were scheduled to bilateral inguinal hernia surgery wil be enrolled the study. the patients wil randomly assign to receive an ultrasound-guided ilioinguinal/iliohypogastric block group or caudal block group ilioinguinal/iliohypogastric block was performed with 2 mg/kg bupivacaine as 0.25 % and total volum wil be divided equally for each side, caudal block wil performe with bupivacaine 2 mg/kg as 0.2%. supplemental analgesia will consist of as requred intraoperative remifentanyl, for recovery unit rescue tramadol, as requred at home ibuprofen. patients wil be evaluated in the recovery unit for analgesia with flacc pain scale, analgesic requirement, complications and parental satisfaction. parents will be also called for analgesia and satisfaction after discharge of the patients in first 24 hours. the evaluation will be performed by a researcher whom does not know which participants belong to the caudal or ilioinguinal/iliohypogastric nerve block group

Eligibility criteria:
inclusion criteria:1- 10 year- old who were scheduled to bilateral inguinal hernia surgery - exclusion criteria: patients with neurological disoder, reoperation for inguinal hernia surgery, coagulation disorder -

Keywords: pediatric, inguinal hernia, caudal, ilioinguinal/ilioihypogastric
a study to assess learning performance in patients with schizophrenia and young and elderly healthy volunteers

Conditions: Schizophrenia

Summary: the purpose of this study is to measure and contrast implicit and explicit learning performance in patients with schizophrenia relative to young and elderly healthy volunteers.

this is an exploratory study involving schizophrenic patients (group 1) and young and elderly healthy volunteers (group 2 and 3 respectively). no investigational medicinal product will be administered. for all participants enrolled (group 1 to 3) the study will consist of an eligibility screening examination (from day -21 up to and including day 1) and 3 cognitive assessment days. cognitive assessments will be made on 2 subsequent days (days 1 and 2) which are separated by overnight sleep. in addition, a session will be performed on day 7. completion of the cognitive test batteries can occur at any time during the day provided that the completion time is comparable on all test days. for each participant, the maximal study duration will not exceed 4 weeks.

Eligibility criteria:
inclusion criteria: * group 1 (patients with schizophrenia): * be a man or woman between 18 and 55 years of age, inclusive * has a known history of schizophrenia of at least 12 months by the referring psychiatrist * receives stable antipsychotic drug therapy (maximally 2) for at least 6 weeks prior to screening * medically stable on the basis of clinical judgment by the investigator * group 2 (young healthy volunteers): be a healthy man or woman between 18 and 55 years of age, inclusive * group 3 (elderly healthy volunteers): be a healthy man or woman between 65 and 85 years of age, inclusive * all participants (group 1 to 3) must be capable of completing the cognitive test battery exclusion criteria: * receives treatment with benzodiazepines, tricyclic antidepressant or anticholinergics * has a positive urine screen for drugs of abuse or alcohol breath test * has a recent history (within previous 6 months) of alcohol or drug abuse * has psychological and/or emotional problems, which would render the informed consent invalid, or limit the ability of the participant to comply with the study requirements * has any condition that, in the opinion of the investigator, would compromise the wellbeing of the participant or the study or prevent the participant from meeting or performing study requirements * group 1 only: a diagnosis of substance dependence within 3 months prior to screening evaluation (patient with a positive drug screen at screening may be included provided use does not lead to a diagnosis of substance dependence and patient consents to abstain from illegal drugs at any time during the study)

Keywords: schizophrenia young healthy volunteers elderly healthy volunteers learning performance
a long-term follow-up study in participants who received cs-101

Conditions: Beta-Thalassemia

Summary: this is a study to evaluate the long-term safety and efficacy of cs-101 in participants who received cs-101 in study cs -101-06 (nct06024876),no investigational drug product will be administered in the study.

this is a study to evaluate the long-term safety and efficacy of cs-101 in participants who received cs-101 in study cs -101-06 (nct06024876). subjects in the cs-101-06 study will be entered into long-term follow-up of this study up to 15 years post-infusion at the completion of the last (12-month) followup visit after treatment with cs-101 injection.

Eligibility criteria:
inclusion criteria: * participants (or his or her legally appointed and authorized representative or guardian) must sign and date informed consent form (icf) and, where applicable, an assent form * participants must have received cs-101 infusion in last study exclusion criteria: * there are no exclusion criteria
quality of life study with adalimumab in rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of the study is to evaluate the ability of adalimumab combined with methotrexate to improve the quality of life in patients with active ra.


Eligibility criteria:
inclusion criteria: * subject is age 18 or older and in good health (investigator discretion) with a recent stable medical history * subject has a diagnosis of rheumatoid arthritis as defined by the 1987 acr criteria * subjects with treatment failure criteria to mtx or mtx + another dmard exclusion criteria: * subject considered by the investigator, for any reason, to be an unsuitable candidate for the study * female subject who is pregnant or breast-feeding or considering becoming pregnant * previous treatment with approved biological agents (etanercept, infliximab, anakinra) in the last 2 months

Keywords: rheumatoid arthritis adalimumab quality of life
cer-001 therapy as a novel approach to treat genetic orphan diseases

Conditions: Familial Hypoalphalipoproteinemia

Summary: the purpose of this study is to assess the impact of 29 intravenous infusions of cer-001 vs. placebo, given at weekly (9 infusions) and biweekly (20 infusions) intervals on carotid vessel wall area as measured by 3tmri, when administered to patients with familial primary hypoalphalipoproteinemia with proven cvd and appropriate background lipid-lowering therapy.

subjects will be required to have acceptable baseline 3tmri imaging of carotid arteries. subjects meeting all eligibility criteria will be randomized to receive cer-001 or placebo (2:1 randomization scheme). randomized subjects will return weekly for a total of 9 infusions and then biweekly for an additional 20 infusions. 3tmri imaging of the carotid and femoral arteries will be performed at week 8, week 24 (primary endpoint) and week 48. the total study duration from randomization can range from 50 to 54 weeks for patients completing the study as designed.

Eligibility criteria:
main inclusion criteria: * male and female patients, aged 18 and above. * apoa-i \< 70 mg/dl * symptomatic or asymptomatic cardiovascular disease * diagnosis of genetically confirmed hdl-c deficiency due to defects in genes coding for abca1 and/or apoa-1 * stable doses of lipid lowering therapies for at least 6 weeks prior to baseline procedures main exclusion criteria: * females of childbearing potential * patients with lcat mutations * patients who experienced recent cardiovascular or cerebrovascular events * hypertriglyceridemia (\>500 mg/dl) * severe anemia (hgb \< 10 g/dl) * uncontrolled diabetes (hba1c \>10%) * congestive heart failure (nyha class ii or higher) * contraindication for mri scanning (e.g., implanted metal objects, claustrophobia)

Keywords: low hdl low apoa-i abca-1 mutations apoa-i mutations
vestibular dysfunction and glucose metabolism

Conditions: Dysfunction of Vestibular System; Glucose Intolerance

Summary: introduction: the global sugar consumption has increased in the past 50 years and their abusive intake is responsible for the insulin resistance and causes the metabolic syndrome - obesity, diabetes mellitus, hypertension and coronary heart disease. objective: to evaluate the effect of scheduled diet without glucose as treatment of labyrinthine disorders associated with glucose-insulin index. study design: a prospective randomized controlled trial. patients and methods: a study conducted at the university of são paulo with 51 patients divided into two groups: diet group (dg) that comprises subjects treated with fractionated diet with glucose restriction and control group (cg) where individuals were not counseled regarding diet. patients underwent computerized dynamic posturography - sensory organization test (cdp - sot) and visual analog scale (vas) in the first and thirtieth days of the study.

51 patientes with dizziness and glucose intolerance diagnosed by the glucose tolerance test were selected. the subjects were submited to cdp sot conditions and a visual analogue scale to measure his self perception about dizziness. then, they were randomized in two groups: with and without fractioned diet without glucose during 30 days. the cdp was repeated in order to verify a statistical difference of sot condition 5 that reflects the individual hability to maintain the own posture with the vestibule solely and cs - that represents the final balance situation. the vas was repeated too in order to verify the self perception of the dizziness after diet.

Eligibility criteria:
inclusion criteria: * dizziness related to fasting or glucose intake * alterations of glucose tolerance test exclusion criteria: * dizziness not related to vestibular problems * ortopedical or neurological diseases * diabetes mellitus

Keywords: posture vertigo glucose metabolism diet scales dinamic posturography
prospective observational trial to evaluate quality of life after stereotactic ablative radiation therapy in patients with hepatocellular carcinoma

Conditions: Hepatocellular Cancer; Quality of Life; Stereotactic Body Radiation Therapy; Observational

Summary: prospective single arm, single center observational study to evaluate quality of life (qol) after stereotactic body radiotherapy for patients with hepatocellular cancer. patients will receive work-up, treatment and follow-up exclusively as routinely done except additional quality of life measurements. qol will be measured by standardized and validated eortc questionaires at different time points during routine follow-up.

prospective single arm, single center observational study to evaluate quality of life (qol) after stereotactic body radiotherapy (sbrt) for patients with hepatocellular cancer (hcc). patients will receive work-up, treatment and follow-up exclusively as routinely done except additional quality of life measurements. this will include contrast-enhanced liver mri or ct and placement of fiducials if necessary. radiation treatment planning will be based on contrast-enhanced fourdimensional computed tomography (4d-ct) with abdominal compression. target volume definition will use an internal target volume (itv) concept. dose prescription and fractionation will be prescribed individually based on lesion size, localisation, movement and liver function according to institutional standards. qol will be measured by standardized and validated eortc questionaires (qlq c-30 and hcc 18) at baseline, at the end of sbrt, during follow up at 6 weeks, 3,6,12,24,36,48 and 60 months.

Eligibility criteria:
inclusion criteria: * histologically or radiologically proven hepatocellular carcinoma * 1-3 lesions suitable for stereotactic radiation therapy * indication for sbrt according to multidisciplinary board evaluation * age \>= 18 years * written informed consent for study participation * mental and verbal ability to complete standardized questionaires according to assessment by investigator (physician) exclusion criteria: * age \< 18 years * prior hcc specific systemic therapy * concurrent oncological systemic treatment * distant metastases * inadequate ability tobe compliant with the protocol or to complete standardizes questionaires * inability to receive contrast-enhanced planning ct * missing ability to give informed consent * legal custody

Keywords: hepatocellular cancer quality of life stereotactic body radiation therapy observational
mask leak with nasal cannula in noninvasive positive pressure ventilation

Conditions: Mechanical Ventilation Pressure High

Summary: this is a prospective randomized cross over study of healthy volunteers undergoing continuous positive airway pressure ventilation via a noninvasive ventilation (niv) mask with and without the addition of nasal cannulas. mask leak will be measured by the ventilator after 60 seconds of spontaneous resting ventilation, with each subject serving as his or her own control.

this is a randomized cross over study. a convenience sample of staff and resident physicians and physician assistants from the san antonio military medical center (sammc) department of emergency medicine will be used to assess nippv mask seal during cpap administration with and without nasal cannula. volunteers will be solicited via grand rounds and staff meetings at san antonio military medical center. subjects will undergo permuted block randomization by random number generator to the order of intervention, mask alone or mask with nasal cannula at 15l/min of oxygen. an emergency medicine trained physician will place equipment and operate the ventilator. after placement of the nippv mask and prior to each study intervention period, appropriate adjustments to enhance mask seal will be made as would happen in a therapeutic setting and the volunteer will be allowed up to two minutes to acclimate to continuous noninvasive positive pressure ventilation. mask leak will be measured by the ventilator unit and will be recorded after 60 seconds of spontaneous restful ventilation.

Eligibility criteria:
inclusion criteria: * 18 years of age * volunteer for study exclusion criteria: * known cardiac disease * known pulmonary disease (to include respiratory infections)
supplemental therapeutic oxygen for prethreshold retinopathy of prematurity

Conditions: Infant, Newborn; Infant, Low Birth Weight; Infant, Small for Gestational Age; Infant, Premature; Retinopathy of Prematurity; Blindness

Summary: the purpose of this trial was to determine the efficacy and safety of supplemental therapeutic oxygen for infants with prethreshold retinopathy of prematurity (rop) to reduce the probability of progression to threshold rop and the need for peripheral retinal ablation.

retinopathy of prematurity (rop) is an abnormal growth of the blood vessels in the eye that occurs primarily in very premature infants. eye development occurs normally in the womb; in infants born prematurely, however, the blood vessels must finish developing outside the protective environment of the uterus. retinopathy of prematurity (also known as retrolental fibroplasia) is a leading cause of blindness and other vision impairments (myopia, strabismus, and amblyopia) in children, both in developed and developing countries. this study was a randomized trial comparing the effects of 2 oxygenation strategies on the progression of rop. infants with prethreshold rop in at least one eye were eligible for the study. enrolled infants were randomized to receive either conventional oxygenation at a pulse oximetry target of 89% to 94%, or supplemental oxygen to achieve a pulse oximetry target range of 96% to 99%. infant were placed on continuous pulse oximetry monitoring and to maintain oxygen saturation, as much as possible, in the assigned target range.

Eligibility criteria:
inclusion criteria: * infants with prethreshold retinopathy of prematurity, confirmed by 2 certified ophthalmologic exams * median pulse oxygen saturation \<94% in room air * median pulse oxygen saturation can be kept safely \>96% on oxygen/ventilator exclusion criteria: * no fatal congenital anomaly or congenital eye anomaly

Keywords: nichd neonatal research network very low birth weight (vlbw) extremely low birth weight (elbw) prematurity
multiple biomarkers in icu sepsis patients

Conditions: Sepsis, Severe; Sepsis; Septic Shock; AKI

Summary: acute kidney injury (aki) is a common condition among sepsis patients in the intensive care unit (icu) and is associated with high morbidity and mortality. oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. some biomarkers would be able to identify who will recover and not recover better than serum creatinine. thus, a combining oxidative stress biomarkers are needed to predict the occurrence or progression of aki in critically ill patients.

acute kidney injury (aki) is a common condition among sepsis patients in the intensive care unit (icu) and is associated with high morbidity and mortality. oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. research on aki has focused on new damage biomarkers for early detection of aki and worsening of renal function. some biomarkers would be able to identify who will recover and not recover better than serum creatinine. thus, a combining functional and damage markers as well as oxidative stress biomarkers are needed to predict the occurrence or progression of aki in critically ill patients. therefore, this prospective, observational study will be conducted in mainland china

Eligibility criteria:
inclusion criteria: * sepsis patients in appropriate age exclusion criteria: * ever blood transfusion ever cpr（cardiopulmonary resuscitation)

Keywords: aki sepsis biomarker renal function oxidative stress
psoas tenotomy under ultrasound

Conditions: Hip Injuries

Summary: the ilio-psoas conflict is a commonly accepted complication after total hip replacement, often linked to a mispositioning of the acetabular prosthetic component that conflicts with the ilio-psoas tendon. to correct these pains, a psoas tenotomy can be proposed. the results proven by the literature are very satisfactory. psoas tenotomy is performed endoscopically, arthroscopically, or more rarely open. the contribution of echo surgery allows to limit the scar ransom but also to free itself from a complex infrastructure to the operating room including an arthroscopy column and an intraoperative fluoroscopy for a conventional tenotomy, this also saves procedural and installation time. no studies to date have described ultrasound-assisted psoas tenotomy yhe investigators conducted a cadaveric study of the feasibility of psoas tenotomy under ultrasound that confirms the feasibility of this technique and the safety of the gesture for the surrounding anatomical structures. the objectives of this study are to assess the feasibility, pain and functional outcomes of ultrasound-assisted psoas tenotomy in patients with ilio-psoas conflict after total hip replacement.


Eligibility criteria:
inclusion criteria: * patients 18 years of age or older * indication of psoas tenotomy for ilio-psoas conflict after total hip replacement * signature of the written informed consent form by the patient * affiliation to a french health insurance scheme or equivalent non inclusion criteria: * vulnerable people: pregnant or breast-feeding women (patients will undergo a pregnancy test: urinary test), adult under guardianship or deprived of freedom. * allergies to local anesthetics * patient on anticoagulant or antiplatelet agents * contraindication to surgery * refusal of patient involvement