Kornimate/medical-research-clean huggingface dataset:
oral health status of asthmatic children

Conditions: Asthma in Children

Summary: this study aimed to investigate the dental caries experience, periodontal health and salivary properties of asthmatic and non-asthmatic children ⁄ adolescents.

a total of 108 children aged from 7 to 16 years old were included in this study and equally divided into two groups: group i (asthmatic children) and group ii (healthy control). all the children were clinically examined to assess their dental caries experience and periodontal health condition. a trained and calibrated examiner (kappa = 0.95) performed the dental caries examination according to world health organization (who) criteria. dental caries status was recorded using the number of decayed, missing or filled teeth (dmft/dmft) and decayed, missing or filled surface (dmfs/dmfs) indices. periodontal health was assessed by gingival index \[gi\] and plaque index(pi). an interview was conducted with parents/guardians and a structured questionnaire was employed to parents in addition to medical records. stimulated salivary samples were collected and assessed for salivary flow rate, salivary ph and buffering capacity.

Eligibility criteria:
inclusion criteria: * aged between 7-16 * asthma diagnosis * asthma treatment for at least 1 year * under asthma medication * healthy controls without any systemic condition exclusion criteria: * asthma diagnosis less than a year

Keywords: asthma children oral health
safety profile of nulojix in home infusion settings

Conditions: Rheumatoid Arthritis

Summary: the study is a retrospective cohort study that utilizes medical records from the biologictx. data accrual starts upon initial home infusion nurse visit until the most recent home infusion nurse visit. infusion related adverse events are quantified as number of patients with adverse event over the total number of patients and number of event over total number of home infusion visits.


Eligibility criteria:
inclusion criteria: * all adult kidney-only transplant recipients currently receiving nulojix in biologictx home infusion service settings
predictors of pulmonary hypertension risk in premature infants with bronchopulmonary dysplasia

Conditions: Bronchopulmonary Dysplasia (BPD); Hypertension, Pulmonary

Summary: a lung condition called bronchopulmonary dysplasia (bpd) is a major cause of poor outcomes and death for premature infants. infants with bpd are also at high risk for pulmonary hypertension (ph)-an important contributor to their condition. previous research has suggested that a protein in the blood, endothelin-1 (et-1), is associated with pulmonary disease. this study aims to investigate the incidence of ph and levels of et-1 among premature babies with bpd. it will also potentially allow us to focus further research efforts and treatment towards these infants, some of our sickest patients at lpch.

this study aims to 1) investigate the incidence of ph among premature infants with bpd versus those without bpd and 2) investigate et-1 levels in infants with bpd-associated ph versus those without bpd-associated ph. this study will allow us to help define a high-risk population at lpch-namely, premature infants with bpd-associated ph. it will also potentially allow us to focus further research efforts and treatment targets towards these infants who encompass some of our sickest patients at lpch. in 2009 the division of lung diseases of the national heart, lung and blood institute (nhlbi) published seven priority areas for research in pediatric pulmonary diseases, one of which was pulmonary vascular disease. an emphasis was made on finding 'clinical strategies that anticipate the development of ph \[which\] may allow earlier recognition and more aggressive therapy, thereby slowing the development of ph in many chronic lung parenchymal and vascular diseases'. this study attempts to address this goal. specifically we aim to evaluate et-1 levels in premature infants diagnosed with bpd and with bpd-associated ph. if et-1 levels are found to correlate with disease state the possibility of prediction and possible early treatment for ph in these infants is raised and merits investigation.

Eligibility criteria:
inclusion criteria: * premature infants (\<30 weeks ega) exclusion criteria: * major congenital malformations (cardiac, respiratory, gastrointestinal) * congenital infection, and/or * known genetic syndromes (i.e. trisomy 21)
foley catheterization following sacrocolpopexy

Conditions: Pelvic Organ Prolapse; Catheter Infection; Urinary Retention

Summary: the objective of this study is to prospectively evaluate the effects of early versus delayed removal of transuretheral catheters following sacrocolpopexy. the investigators specific aim is to determine the optimal time of removal of an indwelling transurethral catheter postoperatively in an effort to reduce the risk of postoperative urinary retention and urinary tract infection associated with catheter use. the investigators hypotheses are as follows: hypothesis 1: longer duration of postoperative catheter use will result in decreased postoperative urinary retention. hypothesis 2: shorter duration of postoperative catheter use will result in lower incidence of urinary tract infection.

patients scheduled to undergo sacrocolpopexy for pelvic organ prolapse at the university of oklahoma health sciences center will be recruited for this study. written informed consent will be obtained from all participants prior to the scheduled surgery and before the randomization process. this study will contain two arms, each with two groups. the first arm will have participants receiving sacrocolpopexy for pelvic organ prolapse; the second arm will consist of participants receiving sacrocolpopexy plus a concomitant procedure for stress urinary incontinence. each participant will be assigned to the arm that matches their scheduled procedure; they will then be randomized into one of the two study groups within that arm. randomization will be performed by placing note cards in sealed envelopes with "group a" or "group b" listed on the card. one envelope will be placed with each participant's preoperative packet and opened on the day of surgery after the operation is complete.on the date of the procedure, a urinalysis will be performed prior to the routine administration of prophylactic antibiotics. at the beginning of the procedure, a transurethral catheter will be placed as is routine for this procedure. at the conclusion of the procedure, the sealed envelope containing the participant's group designation will be opened and she will be assigned to one of two groups. group a participants will have their catheter removed on postoperative day 1 and group b will have their catheter removed on postoperative day 2.

Eligibility criteria:
inclusion criteria: * age at least 21 * scheduled to undergo sacrocolpopexy at the university of oklahoma health sciences center exclusion criteria: * age \< 21 * elevated postvoid residual measurement on preoperative exam * history of urinary retention * medical or surgical indication for prolonged catheterization * history of neurologic problems

Keywords: pelvic organ prolapse catheterization urinary tract infection urinary retention
reaching and engaging depressed senior center clients

Conditions: Depression in Old Age

Summary: the purpose of this study is to test the feasibility of one type of therapy session, virtual augmented engage (engage-a). the research is being done because the researchers are trying to learn if these approaches could be used by therapists in the community social service agencies to treat older adults with depression. the research will also measure clinician satisfaction after training and supervision of utilization of engage-a.


Eligibility criteria:
inclusion criteria: * age ≥ 55 years' old * phq-9 score of ≥ 10 * english or spanish speaking * moca ≥ 24 or mini-telephone moca ≥ 11 * member of/attends one of the reds senior centers * capacity to provide written consent for both research assessment and the engage-a intervention. exclusion criteria: * current active suicidal ideation defined by madrs suicide item ≥ 4 (probably better off dead. suicidal thoughts are common, and suicide is considered as a possible solution, but without specific plans or intention). * presence of psychiatric diagnoses other than unipolar, non-psychotic major depression or generalized anxiety disorder by scid-iv. * severe or life-threatening medical illness (e.g., end stage organ failure). * currently seeing an individual psychotherapist \*(if individuals are willing to go on a hiatus from their individual psychotherapist for the 15 weeks of the study, and meet all inclusion criteria, they will be considered eligible).

Keywords: depression geriatric psychotherapy group
assessment and digital-health based intervention on subclinical organ damage and cardiovascular risk in chinese

Conditions: Cardiovascular Diseases; Cardiovascular Morbidity; Subclinical Organ Damage; Digital Health

Summary: to comprehensively evaluate subclinical organ damage of chinese adults and its association with future cardiovascular disease and events. to observe the significance of intervention based on digital health in preventing the onset and/or progression of subclinical organ damage and cardiovascular disease and events.

in this project, we will register outpatients with cardiovascular diseases and healthy subjects for cardiovascular health check-up in the cardiovascular research clinic of our hospital, comprehensively evaluate their cardiovascular risk factors, subclinical organ damage and cardiovascular diseases at baseline. for participants who is willing to go further, a digital-based intervention will be provided for them to improve their knowledge and behaviour on cardiovascular health. for all participants, their status on subclinical organ damage, cardiovascular diseases and events will be followed within five years. the primary outcome is the composite endpoints of cardiovascular adverse events including acute coronary syndrome, myocardial infarction, heart failure, cardiovascular death. the secondary outcomes include individual cardiovascular adverse events, all-cause mortality, subclinical organ damage including cardiac damage (left ventricular hypertrophy and diastolic dysfunction), renal damage (chronic kidney disease, microalbuminuria), and vascular damage (arterial stiffness, plaques, intima-median thickening, retina arteriosclerosis). by doing these, we will be able to build a registry study and to reveal the epidemiology of subclinical organ damage, validate the association between subclinical organ damage and cardiovascular events in chinese, and explore the significance of digital-based intervention in the prevention from subclinical organ damage and cardiovascular diseases and events.

Eligibility criteria:
inclusion criteria: * aged 18 years or older * willing to participate the study and sign informed consent * available for long-term follow-up exclusion criteria: * severe heart disease (nyha iv) * stage 4 or 5 ckd * malignant tumors or with life expectancy less than 5 years * stroke within 3 months * refuse to participate the study or not available for long-term follow up

Keywords: coronary heart disease arterial stiffness left ventricular hypertrophy left ventricular diastolic dysfunction intima-media thickness cardiovascular events
a study of avastin (bevacizumab) in combination with xelox and tarceva in patients with metastatic colorectal cancer.

Conditions: Colorectal Cancer

Summary: this study will evaluate the efficacy and safety of a first-line regimen of avastin and xelox (xeloda + eloxatin) followed by avastin and tarceva, in patients with metastatic colorectal cancer. patients will receive 6 x 21 day cycles of treatment with avastin (7.5mg/kg iv on day 1), xeloda (1000mg/m2 po twice daily on days 1 to 14) and eloxatin (130mg/m2 iv on day 1). patients free of disease progression will then continue with avastin (7.5mg/kg iv once every 3 weeks) and tarceva (150mg po daily). the anticipated time on study treatment is until disease progression, and the target sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, \>=18 years of age; * adenocarcinoma of colon or rectum, with metastatic disease; * \>=1 measurable lesion. exclusion criteria: * previous treatment with avastin or tarceva; * previous systemic treatment for advanced or metastatic disease; * adjuvant treatment for non-metastatic disease in past 6 months.
a study to investigate the safety and efficacy of gsk4532990 compared with placebo in adult participants aged 18 to 65 years with alcohol-related liver disease

Conditions: Liver Diseases, Alcoholic

Summary: the goal of this study is to assess the safety and efficacy of gsk4532990 in participants with alcohol-related liver disease.


Eligibility criteria:
inclusion criteria: * capable of giving signed informed consent prior to the performance of any study-specific procedures. * able and willing to comply with all study assessments and adhere to the protocol schedule of activities. * in the opinion of the investigator, there is a history of alcohol consumption compatible with either ald or met ald. * a female participant is eligible to participate after meeting additional pre-defined criteria. * participants must meet predefined stable use requirements of concomitant medications based on study criteria. exclusion criteria: * meeting any definition of organ system failure as defined by the north american consortium for study of end-stage liver disease (nacseld) * exceeding pre-defined biochemical parameters for alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp), platelets, international normalised ratio (inr), albumin, estimated glomerular filtration rate (egfr), urine albumin-creatinine ratio (uacr) or glycosylated hemoglobin (hba1c). other primary causes of liver disease based on study criteria. * current malignancy (except for basal cell carcinoma or uterine carcinoma-in-situ) at screening. participants under evaluation for possible malignancy at screening are not eligible. * prior organ transplant or current listing or active consideration for organ transplant during the screening period (except for corneal transplants). * chronic or acute, including partial, known portal vein thrombosis. * prior transjugular intrahepatic portosystemic shunt (tipss) insertion. * any acute cardiovascular event including myocardial infarction, unstable angina, symptomatic heart failure, or cerebrovascular accident in the 6 months prior to screening. * poorly controlled hypertension * clinical suspicion of rhabdomyolysis during the screening period * clinical suspicion of a bleeding episode during the screening period related to portal hypertension and/or low blood fibrinogen level. * body mass index (bmi) \>35 kg/m2 at screening * any liver-related clinical event that started (onset) \<8 weeks prior to baseline (d1).

Keywords: gsk4532990 alcohol-related liver disease steatohepatitis
acute uncomplicated diverticulitis and conservative treatment: accuracy of inflammatory indexes for failure prediction: observational prospective cohort study. (audrip trial)

Conditions: Acute Uncomplicated Diverticulitis

Summary: this is an observational multicenter study that will analyse the accuracy of inflammatory indexes as neutrophil-lymphocyte ratio and platelet-lymphocyte ratio, to predict the failure of conservative treatment of patients diagnosed of acute uncomplicated diverticulitis.


Eligibility criteria:
inclusion criteria: * patients older than 18, diagnosed of acute uncomplicated diverticulitis. * diagnosis made by ct or ultrasound exclusion criteria: * patients younger than 18. * patients diagnosed of acute complicated diverticulitis
evaluation of the accuracy and precision of the masimo labs pulse-hemoglobin-meter monitor in surgical patients

Conditions: Adult Patient Undergoing Major Surgery

Summary: the masimo monitor can measure hemoglobin level noninvasively and accuratly

blood hemoglobin concentration is a very common and essential test to assess patient well being and the need for blood transfusion. in the perioperative period this measurement is further more critical mainly due to the acute nature of blood loss and the need for an immediate response. currently, hemoglobin concentration is determined by analyzing a blood sample. it requires venipuncture or arterial puncture (via an arterial line). besides the patient discomfort there are additional disadvantages such as infection, dealing with blood product, delay with diagnosis, low update rate and cost. masimo labs is in the process of developing a noninvasive monitor to detect hemoglobin concentrations in real time. the monitor uses a probe placed on the patient finger that gives hemoglobin concentration continuously and noninvasively. masimo labs is using a technology that resembles the well accepted and clinically proven pulse-oxymeter. the study will include surgical patients at the uci medical center, preferably in cases that are known to involve major blood loss. for these cases, the anesthesia team places an arterial line for anesthesia purposes. the arterial line is used for continuous blood pressure measurements and blood draw for the assessment of several indices. we plan to compare the hemoglobin concentrations measured from blood samples to the masimo labs pulse-hemoglobin level readings.

Eligibility criteria:
inclusion criteria: * adult having surgery with arterial line exclusion criteria: * upper extremities surgery * pregnant women * children

Keywords: major surgery, excpected blood loss, arterial line
cognitive training to improve mobility in middle-aged and older adults

Conditions: Aging; Age Related Hearing Loss

Summary: the proposed study is designed to evaluate the effect of at-home executive function training on cognition and mobility in older adults with age-related hearing loss (arhl), older adults with normal hearing, and middle-aged adults.


Eligibility criteria:
inclusion criteria: * proficient in english (learned before age 5), can ambulate ≥ 10 meters independently, absence of cognitive impairment (neuropsychological test results in the average range compared to age norms), normal or corrected-to-normal visual acuity (etdrs), availability of a home computer or tablet with internet connection. exclusion criteria: * reported major depression, substance abuse or significant psychiatric disorder, uncorrected visual impairment, vestibular impairment, parkinson's disease or other neurological disorder or sequelae, clinically significant musculoskeletal disorders, diseases affecting the ear, or damage to the ear (e.g., occupational noise), onset of hearing loss prior to adulthood.

Keywords: cognitive training executive function aging dual-task walking near-infrared spectroscopy hearing loss middle age mobility
using of testes' shocker in improving sexual activity

Conditions: Sexual Dysfunction; Sexual Abstinence; Sexual Desire Disorder; Erectile Dysfunction; Erectile Dysfunction Following Radical Prostatectomy; Erectile Dysfunction Following Cryotherapy; Erectile Dysfunction With Diabetes Mellitus; Erectile Dysfunction Following Radiation Therapy; Erectile Dysfunction Following Urethral Surgery; Erectile Dysfunction With Type 2 Diabetes Mellitus

Summary: using of testes' shocker in treating the sexual dysfunction.

using of electrical shocks in treating sexual dysfunction in males, rectile dysfunction and inability to perform sexually good.

Eligibility criteria:
inclusion criteria: * all patients with sexual dysfunction or erectile dysfunction exclusion criteria: * patients with trauma or other causes that make them inactive sexually
prf+1% mf for class ii mandibular furcation defects

Conditions: Furcation Defects

Summary: the aim of the present trial is to evaluate the efficacy of prf with 1% mf in treatment of mandibular class ii furcation defects and its comparison to prf and access therapy alone.

background: for improving efﬁcacy and outcomes of regenerative therapy for furcation defects, various materials has been investigated in addition to access therapy. platelet-rich fibrin (prf) having concentrated growth factors and cytokines and metformin (mf), an efficacious member of biguanide group are known to enhance periodontal regeneration. the aim of the present trial is to evaluate the efficacy of prf with 1% mf in treatment of mandibular class ii furcation defects and its comparison to prf and access therapy alone. methods: this randomized trial was conducted on 75 patients with mandibular class ii furcation defects. defects were surgically treated with either access therapy alone (group 1), access therapy+prf (group 2), and access therapy+ prf+1% mf (group 3). clinical parameters like probing depth (pd), relative clinical attachment level {vertical (rvcal) and horizontal (rhcal)}, modified sulcus bleeding index (msbi) and site specific plaque index (pi) were evaluated at baseline and 9 months post-operatively. radiological assessment of bone defect fill was done at baseline and 9 months.

Eligibility criteria:
inclusion criteria: * buccal degree ii furcation defects in endodontically vital, asymptomatic mandibular first and second molars with a radiolucency in the furcation area on an intraoral periapical radiograph with probing depth (pd) ≥ 5mm and horizontal ≥ pd 3mm after phase i therapy i.e, scaling and root planing (srp); * no history of antibiotic or periodontal therapy in the preceding 6 months. exclusion criteria: aggressive periodontitis patients * systemic conditions known to affect the periodontal status; * medications known to affect the outcomes of periodontal therapy; * hematological disorders and insufficient platelet count (\<100,000/mm3); * pregnancy/lactation; * smoking and tobacco use in any form * immunocompromised individuals; * those having unacceptable oral hygiene (plaque index \[pi\] \>1.5). * teeth with furcation involvement, non-vital teeth, and carious teeth indicated for restorations and mobility of at least grade ii were also excluded.