Kornimate/medical-research-clean huggingface dataset:
preterm infants born to homeless mothers.

Conditions: Prematurity; Extreme

Summary: in recent years, the number of homeless patients who are accommodated by the samu social has increased. these patients are in a situation of financial, but also often social and psychological precariousness. the literature already shows us that precariousness and homelessness are a risk factor for prematurity, but also for the patients themselves, a risk of more frequent recourse to emergency services and of late consultation for advanced pathologies. the objective of this study is to evaluate the fate and quality of medical follow-up of children born very premature (≤33sa) to homeless mothers.

the hospital of pontoise is the largest maternity hospital in the department (val d'oise, 95) with 4449 births in 2021. it has a type 3 neonatal intensive care unit where approximately 150 premature babies under 32 weeks of age are hospitalized each year, including 80 premature babies under 28 weeks of age. these children require a specific and prolonged follow-up after hospitalization, including medical consultations to evaluate their neurodevelopmental development, but also the prevention of rsv infection (respiratory syncitial virus). in recent years, the number of homeless patients who are accomodated by the samu social has increased. these patients are in a precarious financial, but also often social and psychological situation. the literature already shows us that precariousness and homelessness are a risk factor for prematurity, but also for the patients themselves, a risk of more frequent recourse to emergency services and late consultation with advanced pathologies. the aim of this study is to evaluate the fate and quality of medical follow-up of children born very premature (≤33sa) to homeless mothers, by answering the following questions: * what about the follow-up of their very premature child? * how does the department organize itself to ensure optimal follow-up for these patients?

Eligibility criteria:
inclusion criteria : all infants born at or below 33sa: * born between january 2019 and december 2021 * at the rené dubos hospital in pontoise * whose mother did not have a fixed address at the time of discharge. nb: mothers who do not read french well will have the study explained to them by the doctor who follows their child during a consultation, or by telephone. exclusion criteria : - opposition of the mothers

Keywords: premature homeless extreme prematurity
safety and efficacy of a heparin-coated intraocular lens in uveitis

Conditions: Cataract; Uveitis

Summary: to investigate the safety and efficacy of a heparin surface-modified intraocular lens in patients with uveitis undergoing cataract surgery. to evaluate the safety and efficacy of intraocular lens implantation in patients with severe uveitis.

patients with uveitis are at high risk for significant complications following cataract surgery with intraocular lens implantation. complications may result from the surgery itself or may develop after surgery as a result of the intraocular lens. complications related to intraocular lens implantation include iris adhesions to the intraocular lens, which can result in lens capture; cellular deposits on the surface of the lens that can obscure vision; and uveitis. recent studies have identified giant cells on the anterior surface of intraocular lenses in some patients with uveitis, appearing to indicate an intraocular lens-induced inflammatory response. some of these patients have required multiple yag laser procedures to remove these deposits. modification of the surface of the intraocular lens with a layer of heparin may provide a more biocompatible surface. preclinical studies have shown a reduction in the degree of postoperative complications with the heparin surface-modified intraocular lens compared with an unmodified lens. although retrospective case series have examined the use of heparin surface-modified intraocular lenses in patients with uveitis, a randomized, controlled clinical trial has not been performed. this is a randomized clinical trial examining the safety and efficacy of the heparin surface-modified intraocular lens in patients with uveitis. eighty patients with a history of uveitis in an eye requiring cataract surgery will be randomized to receive a heparin surface-modified intraocular lens or the same model of intraocular lens without surface modification. the primary end point of the study will be the development of cellular deposits on the anterior surface of the intraocular lens 1 year after surgery. these cellular deposits will be assessed by a masked grader using standard photographs. secondary end points will include visual acuity, intraocular inflammation, development of anterior and posterior synechiae, and corneal endothelial cell counts.

Eligibility criteria:
women and men 18 years or older with a documented history of uveitis in an eye requiring cataract surgery are eligible for the study. in all patients, the eye must be free of active inflammation for at least 3 months before surgery, with or without anti-inflammatory medications. exclusion criteria include corneal pathology or hazy media that preclude evaluation of the intraocular lens, uncontrolled glaucoma, and diabetes mellitus. monocular patients and patients who cannot be followed for at least 1 year are also excluded.
good shepherd: back to reality series

Conditions: Knowledge

Summary: the purpose of this pilot study is to explore whether the back to reality series of video games - harry's journey, harry's journal, and pathways to care map - increase knowledge of the emotional, social, and psychiatric sequelae of problematic underage marijuana use among homeless and street involved youth. additional objectives were to explore whether the video games promote awareness of the risk of psychosis associated with regular marijuana use among vulnerable youth.

this project pilots the use of educational video games designed to help youth gain awareness of the risk of mental health issues associated with regular marijuana use. by playing the back to reality video games, youths may absorb knowledge about where and how to access community care for symptoms associated with psychosis and problematic cannabis use. the purpose of this study is to pilot test the use of the back to reality series at increasing awareness of the social and emotional implications of underage substance use. this study explores the effects of the back to reality video games compared to control video games (no content about mental health and addiction). street involved and homeless youth registered with good shepherd services between the ages of 16 and 19 years of age will be recruited. the results will be assessed using quantitative questionnaires and qualitative interviews. the data will be statistically analyzed for significant differences in knowledge about the risk of psychosis linked to marijuana use among vulnerable youth. the qualitative interview assesses the participants understanding and views of potential emotional, social, and psychiatric sequelae associated with excessive marijuana use during.

Eligibility criteria:
inclusion criteria: * homeless or street involved youth * registered at any of the good shepherd hamilton youth programs * male, female, or transgender youth from 16-19 years of age as of visit 1. * outpatient status * each youth must understand the nature this study and sign informed consent exclusion criteria: * youth judged by good shepherd staff to be at serious suicidal risk. * youth who are being discharged from good shepherd programming. * youth who are currently admitted in an in-patient unit at a hospital. * youth who scores 5 or more on the video game playing problems questionnaire (teijeiro salguero \& bersabé-morán, 2002). * youth who do not have the capacity to provide informed consent.

Keywords: marijuana use psychosis youth video game
quality of life study in participants with ipf under pirfenidone treatment

Conditions: Idiopathic Pulmonary Fibrosis

Summary: this multicenter, post-marketing, observational study will evaluate quality of life in participants with idiopathic pulmonary fibrosis (ipf) under treatment with pirfenidone (esbriet).


Eligibility criteria:
inclusion criteria: * adult participants for whom pirfenidone has already been prescribed for ipf no more than 4 weeks prior to enrollment, according to their physicians' clinical decision and the terms in the smpc exclusion criteria: * participants who are participating in an interventional study or have received any investigational agent in the past 4 weeks
effects of vojta therapy on the motor function of children with neuromotor disorders

Conditions: Motor Disorders

Summary: functionality and motor skills during activities of daily living have progressively gained importance as tools for classification, assessment and research of neuromotor disorders and the treatment methodology according to dr. vojta or reflex locomotion follows this criterion in the clinical field. vojta therapy is a commonly extended tool in the field of pediatric rehabilitation. this methodology acts on the ontogenic postural function and automatic postural control, on which different environmental aspects will later act. it is not a functional training, to avoid the voluntary movement available according to the pathology by means of compensations. vojta therapy would be the key to unlock the development of gross motor function, later used in the movement of daily life activities, including other therapies such as conventional physiotherapy, sensory stimulation, occupational therapy, etc. this study aims to demonstrate that there are changes in the motor development of children with cerebral palsy with the application of vojta therapy.


Eligibility criteria:
inclusion criteria: * male and female children * diagnosis of cerebral palsy or neuromotor disease exclusion criteria: * healthy subjects * patients receiving other therapy during the procedure

Keywords: vojta therapy neuromotor disorders motor function children
long-term evaluation of biib067 (tofersen)

Conditions: ALS Caused by Superoxide Dismutase 1 (SOD1) Mutation

Summary: the primary objective of the study is to evaluate the long-term safety and tolerability of biib067 (tofersen) in participants with amyotrophic lateral sclerosis (als) and confirmed superoxide dismutase 1 (sod1) mutation. the secondary objectives are to evaluate the pharmacokinetic (pk), pharmacodynamic (pd), biomarker effects, and efficacy of biib067 administered to participants with als and a confirmed sod1 mutation.


Eligibility criteria:
key inclusion criteria: * must have diagnosis of superoxide dismutase 1-amyotrophic lateral sclerosis (sod1-als), and must have completed the end of study visit for either parts a, b, or c of study 233as101 (nct02623699) (i.e., were not withdrawn). * if taking riluzole, participant must be receiving a stable dose for ≥30 days prior to day 1. * if taking edaravone, participant must have initiated edaravone ≥60 days (2 treatment cycles) prior to day 1. edaravone may not be administered on dosing days during this study. * medically able to undergo the study procedures, and to adhere to the visit schedule at the time of study entry, as determined by the investigator. * for female participants of childbearing potential must agree to practice effective contraception during the study and be willing and able to continue contraception for 5 months after their last dose of study treatment. * participants from study 233as101 parts a and b must have a washout ≥16 weeks between the last dose of study treatment received in study 233as101 and the first dose of biib067 received in the current study 233as102. key exclusion criteria: * history of allergies to a broad range of anesthetics. * presence of risk for increased or uncontrolled bleeding and/or risk of bleeding that is not managed optimally and could place a participant at an increased risk for bleeding during or after a lumbar puncture (lp) procedure. these risks could include, but are not limited to, anatomical factors at or near the lp site (e.g., vascular abnormalities, neoplasms, or other abnormalities) and underlying disorders of the coagulation cascade, platelet function, or platelet count (e.g., hemophilia, von willebrand's disease, liver disease). * presence of an implanted shunt for the drainage of csf or an implanted central nervous system (cns) catheter. * prior or current treatment with small interfering ribonucleic acid (rna), stem cell therapy, or gene therapy. * treatment with another investigational drug, biological agent (excluding biib067), or device within 1 month or 5 half-lives of study agent, whichever is longer. * current or anticipated need, in the opinion of the investigator, of a diaphragm pacing system (dps) during the study period. * current or recent (within 1 month) use, or anticipated need, in the opinion of the investigator, of copper (ii) (diacetyl-bis(n4-methylthiosemicarbazone)) or pyrimethamine. * female participants who are pregnant or currently breastfeeding. * current enrollment in any other interventional study. note: other protocol defined inclusion/exclusion criteria may apply
spy intra-operative angiography & skin perfusion in immediate breast reconstruction w/ implants

Conditions: Breast Cancer

Summary: the investigators hope to learn the value of the spy elite® intra-operative angiography in reducing post-operative complications associated with low breast skin blood flow after breast reconstruction using implants.

breast cancer is the most common malignancy among women, and over 180,000 women will be diagnosed with this disease in 2008. last year, over 57,000 breast reconstructive procedures were performed, of which prosthetic reconstruction constituted 76%. immediate reconstruction has been favored over delayed procedures for psychological and technical reasons. however, immediate breast reconstruction is associated with significantly higher complication rates (50-52%) than delayed procedures (32-36%), especially when a prosthetic technique is used. for prosthetic reconstructions, the most significant early complications include necrosis of the mastectomy skin flaps, infection, delayed wound healing and exposure of the implant. the published incidence of these complications ranges between 10% and 40% and is predominantly associated with malperfusion of mastectomy skin flaps. thus, evaluation of skin perfusion and elimination of poorly vascularized areas could help reduce the high rate of complications in immediate breast reconstruction.

Eligibility criteria:
inclusion criteria: 3.1.0 ability to understand and the willingness to sign a written informed consent document. 3.1.1 signed written informed consent. 3.1.2 women with local or regional recurrences after previous breast conserving surgery. 3.1.3 women undergoing delayed post mastectomy reconstruction. 3.1.4 women undergoing prophylactic mastectomy. 3.1.5 women with invasive or non-invasive breast cancer, receiving breast conserving surgery with or without reduction mammoplasty or mastectomy, with or without immediate reconstruction. 3.1.6 women of 18 years of age or older. 3.1.7 ecog or karnofsky performance status 0,1,2. 3.1.8 basic metabolic panel within 6 months 3.1.9 psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements. exclusion criteria: 3.2.1 history of liver or kidney failure will not be eligible. 3.2.2 allergies to iodine containing products will not be eligible. 3.2.3 women who are pregnant will not be eligible.
exoskeleton-assisted training to accelerate walking recovery early after stroke: the target phase ii study

Conditions: Stroke; Paresis; Gait, Hemiplegic

Summary: phase ii: investigating the effects of additional robot-assisted gait training either initiated early (2 weeks post-stroke) or delayed (8 weeks post-stroke) after stroke onset.

general: pre-clinical research has pointed towards a time window of enhanced responsiveness to therapy early after stroke. for example, training has led to substantial recovery if initiated 5 or 14, but not 30 days post-stroke in a rodent model (biernaski 2004). it is suggested that this early period is characterized by heightened levels of plasticity and that training can exploit this leading to improved outcome. the typically observed non-linear recovery pattern in stroke survivors (kwakkel 2004) might suggest that similar mechanisms are induced in the human brain, however clinical research on this is disappointingly sparse. in two closely inter-related phases, we aim to examine the biomechanical changes related to walking recovery in general (phase i) and the specific effects of robot-assisted training (phase ii). by that, we aim to detect a time window in stroke survivors which resembles the same characteristics as observed in animal models. to initiate gait training at an early stage, when patients usually present severe weakness and balance deficits, a mobile exoskeleton is used which is developed to provide intensive walking practice. objectives: (ii.a) are stroke survivors who train with the assistance of a robot at an early stage more likely to achieve independent walking? (ii.b) does additional robot-assisted training modulate the recovery of standing and walking ability by enhancing behavioral restitution?

Eligibility criteria:
inclusion criteria: * first-ever, mri- or ct-confirmed, ischemic or hemorrhagic, anterior circulation stroke * age: 18 - 90 years * baseline assessments within the first 14 days after stroke onset * unable to walk independently at baseline (fac \<3) * moderate to severe weakness of the lower limb at baseline (mi \</=75) * pre-morbid independence in activities of daily living (mrs \ 3) * able to communicate and comprehend * sufficient motivation to participate * provided a written informed consent exclusion criteria: * no other neurological condition affecting motor functions of the lower limbs * pre-existing musculoskeletal impairment severely affecting the gait pattern * body weight \> 100 kg * severe spasticity or contractures that prevent safe use of the exoskeleton * medically unstable to participate in additional therapy sessions

Keywords: stroke rehabilitation robotics
epidemiology of community acquired pneumonia in north israel

Conditions: Community Acquired Pneumonia

Summary: pneumonia in general and cap in particular is considered as one of the most common bacterial infections, associated with high rates of morbidity and mortality and is highly significant economically since all respiratory infections, and pneumonia especially, cause about 80% of antimicrobials use in the community. the high frequency of respiratory infections and the excessive use of antimicrobials are major contributors to the development of pathogens resistant to antimicrobials. in addition, in cap almost all patients are treated empirically, without identification of causing pathogen. aim of study: to identify common pathogens causing cap in hospitalized patients in north israel.

pneumonia in general and cap in particular is considered as one of the most common bacterial infections, associated with high rates of morbidity and mortality. cap is highly significant economically since all respiratory infections, and pneumonia especially, cause about 80% of antimicrobials use in the community. the high frequency of respiratory infections and the excessive use of antimicrobials are major contributors to the development of pathogens resistant to antimicrobials. in addition, in cap almost all patients are treated empirically, without identification of causing pathogen. cap is divided to two principal groups: bacterial cap and atypical cap. since pathogens are different, treatment approach is also different. the main obstacle is absence of adequate diagnostic immediate and cheap tools to enable identifying pathogen and hence treatment is not always appropriate. giving the right therapy at the right time is of major importance since early start of correct treatment is linked to morbidity and mortality of patients. for prescribing appropriate empiric therapy, knowing the epidemiology of cap, i.e. the frequent causing pathogens according to age groups and other demographic characteristics, is essential. unfortunately, except one study conducted 10 years ago by dr. liberman from soroka medical center, there is no characteristic information regarding causing pathogens. lacking this data, might result in selecting inadequate treatment. material \& methods: we should enroll about 300 patients hospitalized in ha'emek medical center with the diagnosis of cap, in order to make the study results statistically significant. in addition to demographic and clinical data, following tests will be performed: 1. blood cultures 2. sputum 3. pcr - throat culture to the following pathogens: * mycoplasma pneumoniae * chlamydia pneumoniae * legionella * adenovirus * influenza a * influenza b * rsv * metapneumovirus * parainfluenza * pneumococcal antigen in urine

Eligibility criteria:
inclusion criteria: * community acquired pneumonia * hospitalization exclusion criteria: * immunocompromised patients * patients under chemotherapy treatment * patients under steroids treament

Keywords: community acquired pneumonia
the leukotriene modifier or corticosteroid or corticosteroid-salmeterol trial

Conditions: Asthma

Summary: this research study will compare the treatment effects of three different asthma medications in asthma subjects whose asthma is well controlled when they take fluticasone, an inhaled corticosteroid. the treatments are fluticasone, montelukast (an anti?leukotriene drug), and a combination therapy of fluticasone and salmeterol (a long-acting beta-agonist). fluticasone, montelukast, and the combination therapy of fluticasone and salmeterol (advair diskus®) are all approved for the treatment of asthma. we are looking at whether the three treatments are equally effective for reducing the number and the severity of asthma attacks in subjects with mild to moderately severe asthma.

this trial will attempt to investigate whether asthmatic patients that are well controlled with low-dose twice daily inhaled corticosteroid (ics) therapy can safely be switched to other modes of controller therapy without loss of asthma control. patients demonstrating good control on twice-daily low-dose ics will be randomized to one of three treatment groups: once-daily low-dose ics (fluticasone), leukotriene receptor antagonist (montelukast), or once-daily combination therapy (fluticasone-salmeterol).

Eligibility criteria:
inclusion criteria: * physician-diagnosed asthma * age 6 or older * pre-bronchodilator forced expiratory volume (fev1) of at least 60% of predicted * beta-agonist reversibility or airways hyperreactivity by methacholine challenge * juniper asthma control score of 1.5 or greater if not on daily controller * good current health exclusion criteria: * current or past smoking (greater than 20 pack-years) * chronic or current oral steroid therapy * pregnancy, lack of effective contraception (when appropriate), lactation

Keywords: asthma asthma control