Kornimate/medical-research-clean huggingface dataset:
application of physical activity counseling program

Conditions: Healthy Lifestyle

Summary: abstract implementation of physical activity counseling program in healthy adult individuals it was planned to investigate the effects of physical activity counseling on physical fitness level, physical activity level, depression level, sleep quality, quality of life and the change in the number of daily steps. 48 healthy adults aged 18-65 years will be included in the study. participants will be randomized to the experimental group receiving videoconferencing counseling for eight weeks and the control group receiving single-session informational counseling. participants will be evaluated with online questionnaires and physical fitness tests during the video conference before the study begins, at the end of the first month and at the end of the second month. online surveys to be applied; pace score, physical activity readiness questionnaire (par-q), short form international physical activity questionnaire (ipaq-sf), pittsburgh sleep quality index (puki), beck depression inventory (bdi), world health organization quality of life scale-short form ( whoqol-bref) and physical fitness tests; plank test, curl up test, modified push up test and squat test. demographic information of the participants such as age, weight, height will be recorded. in addition, all participants will record their step counts with the pedometer application they download to their phones one week before the study starts and for one week after the study ends.


Eligibility criteria:
inclusion criteria: * not having a co-morbid disease that would prevent physical activity * having internet access and equipment to make video calls * working remotely exclusion criteria: * having a diagnosis of any neurodegenerative or chronic disease * having significant cardiovascular, neuromuscular or endocrine disorders that limit regular physical activity * recent myocardial infarction or other acute cardiac event, unstable angina, uncontrolled cardiac arrhythmias * in the past 2 months having had covid 19

Keywords: physical activity quality of life sleep habits depression videoconferencing telehealth
trunk control tests in post-stroke context: validity and reliability study

Conditions: Stroke

Summary: context: after stroke, most patients suffer from hemiparesis with variable functional consequences that can strongly impact autonomy in daily activities. motor recovery is, therefore, an essential part of the therapeutic strategy in order to optimize the patient's capacities and functional autonomy. some authors suggest that trunk control would be essential in the capacities of standing balance, transfer tasks and gait. however, no studies have tested the reliability and validity of proprioceptive and sitting balance clinical tests for patients with post-stroke hemiparesis. these tests would be very useful in advancing our understanding of trunk impairments and for clinicians to manage an appropriate treatment strategy. objective: the main objective is to assess the reliability of the trunk positional sense test, the unstable sitting test with forceplate and the modiﬁed functional reach test (mfrt) in individuals with post-stroke hemiparesis. the secondary objectives is 1) to assess the validity of the trunk positional sense test and the unstable sitting test with forceplate, 2) to assess the validity of a phone inertial captors to assess the instable sitting. method. - thirty-two individuals with subacute post-stroke hemiparesis will be included in this study. after clinical tests (trunk strength, balance assessment in standing and sitting, timed up and go test), the mfrt, trunk positional sense test and unstable sitting will be evaluated by two physiotherapists in a ﬁrst session (inter-rater reliability). after a rest of 2-4 h, a second similar session was conducted with the first physiotherapist (intra-rater reliability). for unstable seated balance, two tools will be used: the force platform and a smartphone. reliability will be tested by calculating the intraclass correlation (icc) and bland-altman analysis. for trunk positional sense test and unstable sitting test, the validity will be tested with correlations with each clinical test. the validity, between forceplate variables and inertial phone variables, will be tested with correlations. perspectives. - the promotion of quality tests to assess patients in clinical practice is essential. the results of this study should provide knowledge for selecting the best trunk control tests to assess the individuals after stroke and to understand the influence of trunk control on functional activities.


Eligibility criteria:
inclusion criteria: * post stroke * subacute phase * able to stay stable in sitting position during 30 seconds * medical stability * able to understand the consign (mini-mental state examination \>22) exclusion criteria: * medical complications * hearing disorders * previous pathologies associated with spinal disorders * back pain

Keywords: stroke trunk postural control reliability validity
impact of different modes of ventilation with laryngeal mask airway on pediatric cataract surgery

Conditions: Ventilation; Laryngeal Mask Airway; Cataract Surgery

Summary: this study will be conducted to evaluate effects of different modes of ventilation on pediatric cataract surgery aiming to a peri-operative stable anesthesia, better surgical satisfaction and post operative recovery. it is hypothesized that controlled ventilation without muscle relaxation will be advantageous to other modes in providing adequate surgical satisfaction with considerable depth of anesthesia and better recovery profile.

anesthetic management in pediatric cataract surgery constitutes a special challenge. any eye movements can lead to an unsatisfactory surgical field and increase the risk of ophthalmological complications. achieving adequate ventilation of children is considered another challenge due to huge variability in size and lung maturity. spontaneous breathing is a popular mode of ventilation with several beneficial effects. controlled ventilation without muscle relaxation using laryngeal mask airway is attractive option because the side effects of muscle relaxants are avoided. therefore, this study will be conducted to evaluate effects of different modes of ventilation on pediatric cataract surgery aiming to a peri-operative stable anesthesia, better surgical satisfaction and post-operative recovery. this prospective, randomized, comparative clinical study will include 150 children who will be scheduled for elective cataract surgery under general anesthesia in mansoura ophthalmology center over one year. informed written consent will be obtained from parents of all subjects in the study after ensuring confidentiality.the study protocol will be explained to parents of all patients in the study who will be kept fasting prior to surgery. patients will be randomly assigned to three equal groups according to computer-generated table of random numbers using the permuted block randomization method. in the first group, spontaneous ventilation will be maintained with pressure support; while in the two other groups, mechanical ventilation will be applied with pressure controlled modes. the collected data will be coded, processed, and analyzed using spss program. all data will be considered statistically significant if p value is ≤ 0.05.

Eligibility criteria:
inclusion criteria: * american society of anesthesiology (asa) i and ii patients. * scheduled for elective cataract surgery. exclusion criteria: * parental refusal of consent. * contraindication to use of supraglottic airway device as gastroesophageal reflux and oropharyngeal pathology. * hyperactive airway disease or respiratory diseases. * children with developmental delays, mental or neurological disorders. * bleeding or coagulation diathesis. * history of known sensitivity to the used anesthetics. * previous surgery in the same eye.
determining effectiveness of an mhealth intervention to provide adolescent cbt

Conditions: Adolescent Depression; Anxiety Disorders

Summary: washington university will evaluate the acceptability and effectiveness of a mobile health (mhealth) intervention to provide cognitive behavioral therapy for adolescents with depression.

in this pilot project, washington university will start to evaluate cbot-a, a promising mhealth therapeutic intervention designed to deliver cognitive behavioral therapy (cbt) through an app on a phone or other mobile device. the evaluation will include a randomized trial among 40 adolescents diagnosed with depression and/or anxiety and will assess if cbot-a is usable by teens and likely to provide benefit, and acceptable to adolescents. the primary outcome of depression and anxiety symptoms in adolescents will be assessed at 1 month and 3 months to check for any changes.

Eligibility criteria:
inclusion criteria: adolescents 12-17 years of age and diagnosed with a major depressive disorder (mdd) and/or generalized anxiety disorder by their primary care provider within the past 3 months. exclusion criteria: adolescents with the following conditions (identified by parental report) will be excluded: * participated in formal cbt within the past 12-months * diagnosed with severe depression * diagnosed with the following anxiety disorders - obsessive-compulsive disorders, post-traumatic stress disorder, panic disorder, or specific phobias * a psychiatric hospitalization in the previous month * with significant comorbidities such that the pcp would refer to a mental health professional for treatment, including those with a substance use disorder or a psychotic illness. * are not accompanied by a guardian to the diagnostic visit * without access to a mobile device (cell phone or tablet) for regular use * unable to read and write english * participants may also be excluded at the discretion of the pi.

Keywords: cognitive behavioral therapy mhealth
cardiac autonomic control in children of hiv positive mothers

Conditions: Acquired Immunodeficiency Syndrome; Arrhythmia; Heart Diseases; HIV Infections

Summary: to establish the incidence, clinical spectrum, and natural history of cardiac dysautonomia as defined by heart rate spectral analysis in both hiv infected and noninfected children and to evaluate the value of heart rate spectral analysis for predicting dysrhythmias and sudden death in infants and children born to hiv infected mothers.

background: the magnitude of clinical problems associated with autonomic dysfunction in children with symptomatic hiv infection is great. hemodynamic abnormalities, dysrhythmias, unexplained arrest and/or sudden death are common in hiv positive children, especially when acute deterioration, interventions or neurologic involvement is present. if cardiac dysautonomia is predictive of adverse outcomes in hiv infected children, then a future prospective trial of beta-adrenergic antagonist therapy may be warranted. design narrative: an analysis was performed on data collected under the nhlbi-sponsored multicenter study entitled 'pediatric pulmonary and cardiovascular complications of vertically transmitted human immunodeficiency virus (hiv) infection' and abbreviated p2c2. the p2c2 study was performed in a prospectively defined cohort of 150 children with hiv infection and 350 uninfected control children born to hiv infected women who had been followed since the first month of life to provide understanding of cardiac dysautonomia in early hiv infection. in addition, 198 children with symptomatic hiv infection were analyzed to provide an assessment of cardiac dysautonomia in later stages of pediatric hiv infection. heart rate spectral analyses were performed on 2196 holter monitor recordings from these patients followed at the five p2c2 clinical centers to capture noninvasively the time varying contributions of the sympathetic and parasympathetic nervous system to the control of heart rate throughout the course of a day. the spectral balance parameters and the changing response of heart rate to the electrocardiogram-derived respiratory signal characterized the responsiveness of the sympathetic and parasympathetic nervous system at rest and during the events of a normal day. autonomic function data were electronically transmitted to the p2c2 data coordinating center at the cleveland clinic and analyzed along with other p2c2 data (eg. infectious, immunologic, growth, renal, neuroendocrine, pulmonary and cardiac) to determine their risk factor potential for cardiac dysautonomia. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
thresholds of slr maneuver in obese patients

Conditions: Gastro Esophageal Reflux

Summary: there is an increasing interest in high resolution manometry (hrm) in the preoperative assessment of patients with obesity, in order to identify the best surgical option. sleeve gastrectomy (sg) has been known to increase the risk of gastro-esophageal reflux disease (gerd). different techniques have been recently developed and validated to offer to these patients protection against pathologic gerd after sg. a recent study found a significant correlation between straight leg raise (slr) maneuver during hrm and a positive ph-study. however, these maneuver has not been validated in an obese population, therefore the normality cut-off remain unknown. a multicenter study with a large number of patients undergoing pre-operative assessment for bariatric surgery could provide a precise threshold to predict pathologic esophageal acid exposure time.


Eligibility criteria:
inclusion criteria: * complete and adequate hrm and ph-impedance study performed within 2 weeks * successfully performed slr maneuver (adequate intra-abdominal pressure augmentation) * obese with bmi\>35 kg/m2 exclusion criteria: * patients under the age of 18 * patients with prior foregut surgery * paraesophageal hiatal hernia * scleroderma * eosinophilic esophagitis * pregnancy
pulmonary surgery and protective mechanical ventilation

Conditions: Lung Neoplasms

Summary: the purpose of this trial is to evaluate the efficacy and the safety of lung protective ventilation during anesthesia in patients undergoing pneumonectomy or lobectomy for lung cancer.

extended description of the protocol could be provided by the urc-est, saint antoine hospital, university of paris-vi and by principal investigator. pneumonectomy or lobectomy is associated with a high risk for postoperative complication. the benefit of lung protective ventilation with low tidal volume has been demonstrated in patients with acute respiratory distress syndrome (ards) and acute lung injury (ali). recent clinical studies have suggested that mechanical ventilation with low tidal volume may also profit in others setting. lung protective ventilation during anaesthesia has been found to limit the inflammatory response in the lung and to decrease postoperative systemic inflammatory response. however, others trials did not found benefit of protective ventilation strategy during anaesthesia. this study will be a randomized, controlled, doubled blind trial comparing two management ventilator strategies during anaesthesia for thoracotomy. only patients undergoing pneumonectomy or lobectomy for lung primitive cancer will be included in this trial. during anesthesia, one group will receive mechanical ventilation with low tidal volume (5 ml/kg of ideal body weight) plus peep and the other will receive tidal volume of 10 ml/kg of ideal body weight without peep. after surgery, data concerning oxygen delivery, blood analysis, complications, cancer recurrence and death will be collected.

Eligibility criteria:
inclusion criteria: * primary lung cancer. * elective pneumonectomy or lobectomy or bilobectomy * written informed consent exclusion criteria: * patients undergoing surgical procedure other than pneumonectomy or lobectomy or bilobectomy * mesothelioma * liver cirrhosis * chronic renal failure * need for mechanical ventilation or non invasive ventilation (cpap for obstructive sleep apnea syndrome for example) before surgery * emergency surgery

Keywords: interoperative care tidal volume postoperative complications pneumonectomy lobectomy mechanical ventilation
effectivness of conservative techniques in management of pas

Conditions: Placenta Accreta

Summary: to evaluate the effectiveness of conservative techniques for placenta accreta spectrum to reduce maternal mortality and morbidity

placenta accreta spectrum (pas) represents the spectrum of clinical conditions when part or whole of the placenta becomes abnormally adherent or invades the myometrium . over the last 40 years, caesarean delivery rates around the world have risen from less than 10% to over 30%, and almost simultaneously a 10-fold increase in the incidence of pas . pas is one of the most dangerous conditions of the pregnancy as it is significantly associated with maternal morbidity and mortality . ultrasound imaging is the most commonly used technique to diagnose pas disorders prenatally. there is also wide variation globally on the management of pas disorders, with some centres opting for a radical approach, whereas others have proposed a range of conservative approaches . the conservative approaches include one-step conservative surgery, leaving the placenta in situ, the triple-p procedure, and transverse b-lynch suture . recently, women's health hospital has adopted a new approach for conservative management of most cases of pas, including wedge resection of the myometrium over the adherent part of the placenta, or a staged-approach following delivery of the fetus starting with meticulous dissection of the urinary bladder form the lower uterine segment, then bilateral uterine artery ligation at a level below the apparent placenta-myometrial bulge, followed by removal of the placenta, after which a catheter is inserted in the cervix and the placental pouch is closed .

Eligibility criteria:
inclusion criteria: 1. - gestational age starting from 28 weeks onwards. 2. - women with at least 1 previous hysterotomy (e.g. caesarean deliveries, myomectomy) 3. - elective or emergent caesarean deliveries exclusion criteria: * a pre-existing decision of performing intrapartum hysterectomy
use of breath stacking technique on regional ventilation in box chest in women with morbid obesity

Conditions: Morbidly Obese

Summary: objectives: to evaluate the effects of the technique of breath stacking (bs) in the distribution of ventilation in the chest in women with morbid obesity. methods: randomized clinical trial, blinded, and controlled with 32 women (bmi ≥ 40kg/m2), separated into two groups: control (gc) with n = 16 and 41.94 ± 9.38 years and group breath stacking (gbs) , n = 16 and 40.38 ± 10.16 years. optoelectronic plethysmography (poe) was used to assess lung ventilation. for the bs technique was used to mask the expiratory branch occluded and wright spirometer. gbs held three techniques with an interval of three minutes. the gc used the same circuit without the occlusion of the expiratory branch. results: gbs was found to be higher in the contribution of tidal volume (vt) into the chest circumference (p = 0.04) and decrease in abdominal compartment (p = 0.03), whereas the cg showed no difference in distribution. spirometric variables: fev1 (%), fvc (%), fev1/fvc (%), vc and ci showed no difference before and after the technical bs and gbs in the gc. conclusions: the technique bs altered the distribution pattern of regional ventilation, resulting in greater contribution in lung volume in the lower rib cage, corresponding to activity of the diaphragm, with redistribution of volume between compartments.


Eligibility criteria:
inclusion criteria: * women aged 19-60 years * bmi ≥ 40 kg/m2 exclusion criteria: * women with chronic lung disease * smokers * neuromuscular disease * disability in performing the procedures
role of low-intensity shock wave therapy in penile rehabilitation post nerve sparing radical cysto-prostatectomy

Conditions: Bladder Cancer

Summary: the aim of this clinical trial is to evaluate the role of extracorporeal low-intensity shock wave therapy in penile rehabilitation post nerve sparing radical cysto-prostatectomy.

60 patients for whom nerve sparing radical cystoprostatectomy will be carrried out, penile rehabilitation by using low intensity extracorporeal shock wave therapy will be applied in 20 patients, another 20 patients will receive oral phosphodiestrase type 5 inhibitorrs and 20 patients will not receive any interventions in the control group.

Eligibility criteria:
inclusion criteria: - patients will be eligible if he is sexually motivated and potent men with stable relationship of more than 6 months duration who will undergo nerve sparing radical cysto-prostatectomy for organ-confined bladder cancer. exclusion criteria: - 1. men with peyronie's disease. 2. inflammation in the shock wave area. 3. evidence of disease failure after surgery. 4. patients developing postoperative complications requiring hospital readmission after surgery which interferes with the process of swl. 5. unstable medical or psychiatric disorder.

Keywords: cystoprostatectomy sexual function phosphodiestrase 5 inhibitors low intensity extracorporeal shock wave therapy erectile dysfunction penile rehabilitation
coverage and cost-of-care (cc) links- financial navigation program

Conditions: Financial Stress; Hematologic Cancer; Survivorship

Summary: this trial is a mixed-methods, non-randomized design guided by the consolidated framework for implementation research (cfir) to develop, implement, and evaluate coverage and cost-of-care links (cc links) -a novel financial navigation intervention for hematologic cancer survivors and their caregivers.

the cc links intervention included an oncology financial navigator who worked in the hematology-oncology clinic. the navigator's functions included: screening for financial hardship to identify unmet financial needs (using the comprehensive score for financial toxicity (cost) and national comprehensive cancer network's distress thermometer; initiating cost of care conversations; providing cost of care estimates; ensuring adequate health insurance coverage and assisting with applying for additional coverage; assisting with internal financial assistance program applications; connecting survivors/caregivers with disease specific resources and other external assistance programs; coordinating discharge planning; referring survivors to social workers and other staff/resources as needed; and, coordinating financial assistance services as survivors/caregivers transition between outpatient and inpatient settings.

Eligibility criteria:
inclusion criteria: * hematological cancer patients from the division of hematology and bone marrow transplantation at the university of kentucky * caregivers of cancer patients * positive screening for financial hardship exclusion criteria: - unable to provide consent

Keywords: financial navigation quality of life hardship caregivers financial toxicity