Kornimate/medical-research-clean huggingface dataset:
arestin - use in subjects with peri-implantitis (with subgingival microbiological evaluation)

Conditions: Peri-Implantitis

Summary: the objective of the study is to evaluate the safety, effectiveness and anti-microbial effects of arestin (minocycline hcl) 1 mg microspheres in the treatment of subjects with peri-implantitis, when used in combination with mechanical debridement. the hypothesis of the study is that arestin in combination with mechanical debridement is more effective in the treatment of peri-implantitis when compared to mechanical debridement alone. the primary efficacy measure will be the reduction of probing depth at day 180 as measured at qualifying implant sites.


Eligibility criteria:
inclusion criteria: * a minimum of one osseointegrated implant with a diagnosis of peri-implantitis * absence of any significant oral soft tissue pathology * at least one peri-implant site with an average of 2 probing depth readings between 5mm and 7mm (inclusive) when using a light force and with bleeding on probing within 30 seconds of the probing * confirmed evidence of pathologic bone loss * at least 1mm of keratinized gingiva present around the implant exclusion criteria: * pregnancy * allergy to tetracycline-class drug(s) * systemic medical condition(s) requiring antibiotic prophylaxis prior to invasive dental procedures * presence of active systemic infectious disease such as hepatitis, hiv, history of tuberculosis * diagnosis of clinically significant or unstable organic disease, or compromised healing potential * signs of untreated advanced periodontal disease and/or poor oral hygiene * subjects having a probing depth greater than 8mm at time of enrollment * subjects presenting with mobility of any dental implant * subjects having a qualifying implant under occlusal trauma or overloaded (as determined by the investigator)
efficacy of platelet rich plasma (prp) on mouth opening and pain after surgical extraction of mandibular third molars.

Conditions: Tooth Extraction

Summary: wisdom tooth extraction is the most common surgical procedure being carried out in oral surgical departments. the complications carried by post operative period include pain and trismus and may affect patient's quality of life. prp is an autologous concentrate of platelet in plasma and accelerate healing by production of growth factors. prp is prepared from patient's own blood and later packed with gel sponge (spongistone) in the experimental group immediately after surgical extraction of mandibular third molar teeth, followed by suture placement to close the surgical site.

wisdom tooth extraction is the most common surgical procedure being carried out in oral surgical departments. the complications carried by post operative period includes pain, swelling, trismus , along with disturbance in post extraction wound healing which may significantly affect patient's quality of life. prp is an autologous concentrate of platelet suspended in plasma and accelerate healing by production of various growth factors. prp is prepared from patient's own blood and later packed with gel sponge (spongistone) in the experimental group immediately after surgical extraction of mandibular third molar teeth, followed by suture placement to close the surgical site. prp speeds up healing by concentration of growth factors which can lessen the inflammation and decreases trismus and pain.

Eligibility criteria:
inclusion criteria: 1. age between 18-45 iyears 2. either gender 3. patients requiring extraction of mandibular 3rd molars 4. asa grade1 5. nonsmokers \& non alcoholics 6. not allergic to any medicines 7. no pain before the extraction procedure 8. no trismus, i.e. normal mouth opening before the extraction procedure - exclusion criteria: a) systemic diseases b) compromised immune system c) platelet count less than 1.5 lacs/cmm d) allergy to drugs e) patients not willing to participate in the study f) pregnant females/lactating mothers g) presence of pericoronitis, periapical infection or any associated lesion. -
study of 90y-hll2 to treat non-hodgkin's lymphoma

Conditions: Non-Hodgkins Lymphoma

Summary: the purpose of this trial is to determine the safety of 90y-hll2 at different dose levels in the treatment of non-hodgkin's lymphoma.


Eligibility criteria:
disease characteristics: * patients with a documented histologic or cytologic diagnosis of b-cell nhl. * patients who have failed at least one regimen of chemotherapy and are not eligible for any alternate therapies of higher therapeutic priority. * patients with at least one measurable tumor site \> 1.5 cm in at least one dimension. prior/concurrent therapy: * chemotherapy: patients must have failed standard therapy or are not eligible for any alternate therapies of higher therapeutic priority. * biologic therapy: patients who have received human or humanized monoclonal antibodies will be eligible provided pre-study evaluations demonstrate no significant reactivity with hll2 igg (i.e., haha). * radiotherapy: no prior radiation therapy to \>25% of the bone marrow. no prior radiation to maximal tolerable levels for any critical organ (e.g., 2,000 cgy for the lungs and kidneys). patients who have had whole pelvic irradiation are not eligible. patient characteristics/inclusion criteria: * age range: male or female at least 18 years of age * performance status: patients with a karnofsky performance status \> 60% (or equivalent, ecog 0-2) and expected survival of at least 12 weeks. * hematopoietic: hemoglobin \> 10 g/dl; anc \> 1.5x10\^9/l; platelets \> 100x10\^9/l; * hepatic: serum bilirubin \< 2.0 mg/dl; ast and alt \< 2 x uln w/o liver metastases or \<5 x uln w/liver metastases * renal: creatinine \< 2.0 mg/dl * cardiovascular: patients with lvef \>/= 50% by muga or 2d-echo. * pulmonary: patients with dfco and fev1 \>/= 60% by required pulmonary function tests. * other: patients agreeing to use a medically effective method of contraception while enrolled in the study. a pregnancy test will be performed on each premenopausal female of childbearing potential immediately prior to entry into the study. patients able to understand and give written informed consent.
pals for pap smear follow up

Conditions: Health Knowledge, Attitudes, Practice

Summary: in this study, the researchers will utilize information gained from patient interviews about their knowledge of the cervical cancer screening and treatment process, and perceived barriers surrounding appropriate follow up, to create content for the intervention.

the overall goal of this research is to develop and test an intervention designed to improve knowledge and follow up among underserved women with abnormal pap smears. the researchers will use a unique web-based platform, the patient activated learning system (pals), which provides engaging and informative video and text designed to improve patient knowledge specifically among underserved populations. twenty diverse patients with abnormal pap smears will be recruited from the women's health colposcopy clinic for initial qualitative interviews. forty patients from the same population will then be engaged in a pre-post pilot to examine feasibility, acceptability, and impact of modules on improving knowledge.

Eligibility criteria:
inclusion criteria: * all women 21-65 years with diagnosis of abnormal pap smear presenting to women's health colposcopy clinic at wcmc * access to a smartphone * english or spanish speaking exclusion criteria: * pregnant women * non-english or spanish speakers
oct pilot in esophagus

Conditions: Barrett Esophagus

Summary: this is a pilot study to test a newly developed optical coherence tomography (oct) device to determine 1) whether adequate tissue contact can be attained to acquire high quality images, and 2) to identify if these images can discern whether the imaged tissue is squamous or barrett's esophagus (be) epithelium.


Eligibility criteria:
inclusion criteria: 1. presenting to university of north carolina (unc) for routine care upper endoscopy 2. meet one of the following criteria: 1. presenting to unc for upper endoscopy of gi conditions without esophageal symptomology for with no history of gastroesophageal reflux disease (gerd) or other esophageal condition affecting the epithelium (asymptomatic controls), or, 2. history of dysplastic or non-dysplastic barrett's esophagus with prague criteria c1+ or m3+ 3. aged 18 to 80 4. able to read, comprehend, and understand the informed consent document. exclusion criteria: 1. prior esophageal surgery (uncomplicated nissen fundoplication ok) 2. pregnant women 3. unable to provide written informed consent
evaluating the efficacy and safety of adebrelimab in combination with chemotherapy and ldrt as 1l treatment for es-sclc

Conditions: Small Cell Lung Cancer Extensive Stage

Summary: a multicenter, open-label, phase ⅲ randomized controlled trial evaluating the efficacy and safety of adebrelimab in combination with chemotherapy and low-dose radiotherapy (ldrt) as first-line treatment for extensive-stage small cell lung cancer (sclc)

a multicenter, open-label, phase iii randomized controlled trial evaluating the efficacy andsafety of adbelizumab in combination with chemotherapy and low-dose radiotherapy (ldrt) as a first-line treatment for extensive-stage small cell lung cancer (sclc). at least 202 participants will be enrolled in this study.

Eligibility criteria:
inclusion criteria: * participants aged 18 to 75 years, regardless of gender; * ecog performance status (ps) score of 0-1; * expected survival duration of no less than 8 weeks; * histologically or cytologically confirmed extensive small cell lung cancer (according to the valg staging system); * subjects must not have received systemic therapy or radical radiotherapy for extensive sclc prior to enrollment. exclusion criteria: * tissue classifications of mixed small cell lung cancer and non-small cell lung cancer; * patients who have undergone major surgical procedures within 28 days prior to the initial administration of the study drug, or those planning to undergo major surgery during the study period (as determined by the investigator); * receipt of live attenuated vaccines within 28 days before the first dose or planned for the duration of the study; * participation in another clinical trial within 28 days preceding initial dosing, involving any experimental agents; * history of receiving chest radiotherapy or plans for intensive chest radiotherapy prior to systemic therapy; * any previous t-cell co-stimulation or immune checkpoint therapies administered; * documented history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation.\&amp;#34;

Keywords: sclc adebrelimab ldrt
exercise training as medicine for substance use disorder patients

Conditions: Substance Use Disorders

Summary: this study compares the effects of high dose and low dose, high intensity, endurance training and strength training in substance use disorder patients. the hypothesis is that the increase in endurance (measured as maximal oxygen uptake) and strength (measured as maximal strength) will be similar in both the high dose and low dose training groups after 24 training sessions over eight weeks. the rationale for this assumption is based on the patient groups poor physical capacity, supporting that a lesser physical workload is needed to achieve a substantial increase in physical capacity. the practical implication could be higher training attendance, because it is likely easier to motivate the patient group when they only have to perform half the workload. it is paramount for this patient group to increase their physical capacity and consequently augment their physical health status since they are in a high-risk group for developing life-threatening lifestyle related diseases.


Eligibility criteria:
inclusion criteria: * being an inpatient at the clinic * free of known cardiovascular disease, pulmonary disease and cancer exclusion criteria: * not able to perform a maximal treadmill test * not able to perform a maximal strength test in hack squat

Keywords: resistance training endurance training
the trauma recovery and resiliency research project

Conditions: Posttraumatic Stress Disorders

Summary: the overall purpose of this study is the assessment of treatment outcome among traumatized patients seeking individual and/or group therapy at the victims of violence program. the study gathers information from patients using quantitative (self-report) and qualitative (interview-based) approaches, to determine changes in symptom patterns and domains of functioning relevant to psychological trauma.

the focus of the trauma recovery and resiliency project is primarily the evaluation of treatment outcome among complexly traumatized patients seeking individual and/or group therapy at the victims of violence (vov) program, a specialty clinic located in the outpatient psychiatry department of the cambridge health alliance and affiliated with harvard medical school. the project has two major components: (1) all patients seeking vov treatment are administered a battery of self-report measures assessing symptoms associated with complex trauma (i.e., interpersonal trauma that is usually repeated and prolonged) (2) a subsample of patients are interviewed using the multidimensional trauma recovery and resiliency interview (mtrri) and its companion rating scale (mtrr; harvey et al, 1994, 2000, 2003) to assess trauma impact, recovery and resiliency on eight domains of psychological functioning. data is analyzed using quantitative and qualitative approaches to evaluate treatment effectiveness and elucidate the recovery trajectories of patients receiving vov treatment. two subprojects include (a) preparation of a treatment manual documenting the women's trauma recovery group, and (b) pilot testing a new interview-based measure of complex trauma symptoms, the symptoms of trauma scale (sots).

Eligibility criteria:
inclusion criteria: * in individual or group therapy at vov program * consents to research participation exclusion criteria: * insufficient proficiency in english to complete self-report measures and/or interview * research participation clinically counterindicated

Keywords: complex trauma trauma recovery resiliency posttraumatic stress individual psychotherapy group psychotherapy
efficacy of an automatic toothbrush

Conditions: Dental Plaque

Summary: the objective of this study is to compare the efficacy in terms of bacterial plaque removal, in a single use, of a new y-shaped automatic electric toothbrush with nylon bristles, compared with the electric toothbrush of similar shape but with silicone bristles, with the manual toothbrush, and with a negative control (no brushing) in a group of volunteer students. primary endpoint: difference in "full mouth plaque score" between before and after brushing. secondary endpoint: sensation of "clean mouth" assessed on vas scale from 0 to 10 where 0 indicates no sensation of clean mouth and 10 maximum sensation of clean mouth. single-center, randomized, controlled, superiority, cross-over, examiner-blinded study with 5 treatments (y-shaped electric toothbrush with nylon bristles, similarly shaped electric toothbrush with silicone bristles, manual brushing for 45 seconds, manual brushing for 2 minutes, no brushing), carried out in a single session and spaced one week apart.


Eligibility criteria:
inclusion criteria: * absence of fixed orthodontic appliances * presence of at least 20 teeth * full mouth plaque score greater than 40% * having provided signed and dated informed consent. exclusion criteria: * subjects with manual inability to perform normal oral hygiene maneuvers * subjects allergic to silicone or nylon.
the effects of glycerol as an optical clearing agent for visualization of the middle ear

Conditions: Tympanosclerosis; Thickened Ears; Healthy; Surgery

Summary: this study will examine the improvement in middle ear optical coherence tomography imaging from the topical application of glycerol to the tympanic membrane in normal, opaque and post-operative ears

this study will explore whether the utility of optical coherence tomography (oct) in otology patients can be enhanced through the application of topical glycerol as an optical clearing agent in patients with normal, opaque and post operative tympanic membranes. in each group of subjects, a comparison will be made between oct images obtained before and after the topical application of glycerol to the tympanic membrane and following washout with saline. images will also be assessed for their diagnostic utility as determined by the visibility of key structures and the change in middle ear mobility caused by glycerol absorption in the tympanic membrane.

Eligibility criteria:
inclusion criteria: * thickened tympanic membrane (e.g. due to fibrosis) x10 * tympanosclerosis of the tympanic membrane x10 * history of middle ear surgery with partial or total ossicular replacement prosthesis and cartilage tympanoplasty x10 * history of cartilage tympanoplasty without prosthesis implantation x10 * normal tympanic membrane without history of middle ear disease x10 exclusion criteria: * narrow or stenotic external auditory canal that prevents visualization of the tympanic membrane * mobility disorder that prevents patient from remaining still during imaging * perforation of the tympanic membrane * open sores or infections of the external auditory canal
time to accurate heart rate on neonatal outcomes

Conditions: Premature Infant; Extremely Low Birth Weight; Extreme Prematurity

Summary: the goal of this trial is to compare the time to first heart rate displayed for ires warmer with resusview and using ires warmer without resusview when used in the resuscitation (e.g. cardiopulmonary resuscitation or breathing assistance) of premature newborns (23 to 32+6 weeks gestation).

this is a prospective interventional randomized control trial. infants born between 23+0 and 32+6 estimated gestational age will be randomized using a computer generate allocation sequence stratified by gestational age. randomization cards will be placed in opaque envelopes. for the intervention group, the care team will use the panda ires warmer with resusview bed during resuscitation interventions in the first 10 minutes of life. during use of the ires-warmer, standard nursing care of an infant on a radiant warmer will be followed. participants assigned to the control group will receive interventions using the same model panda bed without resusview. there is no minimum time for monitoring, and the maximum time depends on clinical determination for use of heart rate feature for each resuscitation event. data including the infant's gestational age, electrocardiogram lead type and activities that occurred during resuscitation will be recorded for the first 10 minutes of life.

Eligibility criteria:
inclusion criteria: * infants who are delivered to mothers over the age of 16 years of age * infants delivered at 23+0 to 32+6 weeks estimated gestational age based on the best obstetric estimate at the time of delivery. * infants without known congenital malformations prior to delivery * antenatal consent exclusion criteria: * infants who are delivered to mothers under the age of 16 years of age * known congenital anomalies of newborn prior to delivery * cardiac defects other than small ventricular septum defect and patent ductus arteriosus * multiples * declined consent * ires warmer with resusview not available at time of delivery

Keywords: electrocardiogram neonatal resuscitation resuscitation of premature infants
investigation on diagnosis and treatment of helicobacter pylori infection by gastroenterologists in shandong province

Conditions: Helicobacter Pylori Infection

Summary: helicobacter pylori can lead to a variety of digestive system diseases.the eradication of helicobacter pylori plays an importment role for the treatment of gastrointestinal ulcer and prevention of gastric cancer .compared with other countries and regions in the world, the infection rate of helicobacter pylori in china can reach more than 50%. the non-standard diagnosis and treatment of helicobacter pylori greatly reduces its eradication rate and increases its drug resistance.therefore, it is very important to strengthen the standardization of diagnosis and treatment to improve the eradication rate. the purpose of this study is to investigate the diagnosis and treatment status of helicobacter pylori among gastroenterologists in general hospitals in shandong province.it can help us to understand the actual situation of diagnosis and treatment of helicobacter pylori in hospitals at all levels, and to provide targeted diagnosis and treatment training for doctors.


Eligibility criteria:
inclusion criteria: * all the gastroenterologists in secondary and tertiary general hospitals of shandong province exclusion criteria: * a hospital that does not include gastroenterology * hospitals and gastroenterologists that refuse to sign informed consent

Keywords: questionnaire helicobacter pylori infection cross-sectional survey
efficacy of myskin patch for the healing of cut injuries and abrasions

Conditions: Wounds and Injuries; Abrasion; Cut Injuries

Summary: evaluation of clinical efficacy of my skin (hydrogel and polyurethane film) plus best practice clinical care in subjects with cut injuries and abrasions with particular regard to: wound healing (complete reepithelialization) and patient's pain. in the context of the study will be collected secondary outcomes related to type of lesion and its clinical evolution through the analysis of the items in the scale of the pressure sore status tool(psst).


Eligibility criteria:
inclusion criteria: * presence of at least an injury cut or abrasion (even if sutured)covered by a dressing of 10x8 cm (80 cm2) * injury treated with conventional dressings type gauze and patch * patients assisted at the emergency care, or at the outpatient * extension of the lesion less than 80 cm2 (including dressings in cm10x8cm) * patient age greater than or equal to 18 years * patients who have given consent to enrollment in the trial and the processing of personal data * patient / lesion that has already been recruited in the study or who have previously passed a period of 10 days (wash-out) of "no treatment" according to the research protocol exclusion criteria: * a end-stage of disease * subjected systemic corticosteroid therapy / radiotherapy / immunosuppressive therapy * suspected or known allergic diathesis to the product of medication * subjects that do not give consent to data processing * dry lesion with necrosis or eschar * presence of both local and systemic infection or inflammation * injuries that to the decision of the provider of care, needs a targeted local treatment other than as provided for in the protocol * patient / lesion that has already been previously recruited into the study, before a period of 10 days (wash-out) of suspension from the same research protocol

Keywords: myskin patch hydrogel bandage occlusive dressing
a pilot study of the envision® surface

Conditions: Pressure Ulcers

Summary: this study is to evaluate the clinical safety and effectiveness of the envision® surface.

this study is to evaluate the clinical safety and effectiveness of the envision® surface placed on the totalcare® frame in pressure ulcer prevention and management, patient comfort, and staff acceptance in the critical care environment

Eligibility criteria:
inclusion criteria: * subject weighs between 70 and 400 pounds subject to remain on envision surface for at least 3 days subject at risk for pressure ulcers (braden score \< 14) or has existing ulcer of any stage subject is able to provide voluntary consent exclusion criteria: * subject requires pulmonary treatment surface subject declines consent

Keywords: pressure ulcers