Kornimate/medical-research-clean huggingface dataset:
clinical trial of interpersonal therapy for survivors of the sichuan earthquake

Conditions: Posttraumatic Stress Disorder; Depression

Summary: the enormous global burden of mental illness has been estimated through the publication of the global burden of disease study. research confirms that populations exposed to mass trauma such as natural disaster bear a particularly high burden of mental disorders, with depression and posttraumatic stress disorder (ptsd) generally being the top two adult psychiatric diagnoses. in traumatized populations, these disorders do not remit with replacement of material losses or resettlement to safe locations, but rather tend to become chronic conditions with attendant disability. ptsd and depression are risk factors for anger, interpersonal discord and violence, not only among those who have trauma and depression, but also among their spouses and children. this "infectious" model of trauma/violence is critically important in the setting of natural disaster, as increased levels of interpersonal violence within the afflicted community hinder its recovery. to date, there has been little research on the interpersonal effects of mass trauma. the proposed research is a randomized controlled trial of "interpersonal therapy" (ipt) versus wait list control (wlc) for survivors of the sichuan earthquake living in shifang, china. ipt, a very effective therapy for depression, has been adapted for ptsd treatment and developing country settings. measures will evaluate success of the treatment not only in terms of individual depression and ptsd symptoms, but also with respect to interpersonal functioning. hypothesis 1: relative to wait list control, fewer subjects who received ipt will meet criteria for depression and ptsd at the conclusion of the rct. hypothesis 2: subjects who received ipt will have greater improvement of social functioning than wait list controls.

interpersonal psychotherapy adapted for local mental health care needs was applied using wait list control design.

Eligibility criteria:
inclusion criteria: * age greater than 18 years; * diagnosis with depressive disorder and posttraumatic stress disorder (ptsd); * ability to attend weekly therapy sessions for 12 weeks and return for post-treatment screening; * ability to give verbal informed consent exclusion criteria: * cognitive dysfunction which requires a higher level of care and/or interferes with ability to participate in ipt; * severe thought or mood disorder symptoms which requires a higher level of care and/or interferes with ability to participate in ipt; * drug and alcohol dependence

Keywords: ptsd earthquake disaster global mental health disaster mental health depression
emergency use of adoptive immunotherapy with cmv-specific t cells after donor bone marrow transplant of an infant with immunodeficiency syndrome and cmv infection

Conditions: Infection; Precancerous/Nonmalignant Condition

Summary: rationale: collecting the t cells from a donor and transplanting them into a patient may be effective treatment for immunodeficiency syndrome and cmv infection. purpose: this clinical trial is studying the emergency use of adoptive immunotherapy with cmv-specific t cells after donor bone marrow transplant of an infant with immunodeficiency syndrome and cmv infection.

objectives: * to determine if adoptive immunotherapy with donor-derived cd4+ and cd8+ cmv- specific cytotoxic lymphocyte cell lines can augment t-cell immunity and treat cmv infection post transplant in a patient with severe combined immunodeficiency syndrome. outline: the patient will undergo hla-matched unrelated donor bone marrow transplantation from a cmv-seropositive donor after undergoing conditioning with 200cgy total-body irradiation per protocol fhcrc protocol 1227. cd8-positive and cd4-positive cmv-specific t cells are collected from the donor and used to generate t-cell lines. if the patient has progressive or persistent cmv infection, then she will receive donor t cells iv over 30 minutes. infusions may be repeated after at least 14 days if the previous infusion was well tolerated and if the cmv infection is persistent or increasing. the patient undergoes blood sample collection at baseline and 7 days after t-cell infusion to assess cmv-specific t-cell response.

Eligibility criteria:
disease characteristics: * adenosine deaminase-deficient severe combined immunodeficiency syndrome (ada-scids) * cmv interstitial pneumonia based on the constellation of clinical and radiological findings patient characteristics: * female * oxygen desaturation (pulse oximetry 85% on room air) * abnormal chest radiograph * no cmv retinitis prior concurrent therapy: * prior ganciclovir and foscarnet sodium

Keywords: infection precancerous/nonmalignant condition
study of probiotics combined with concurrent hyperfractionated chemoradiotherapy and adebrelimab immunomaintenance in the treatment of limited-stage small cell lung cancer (ls-sclc)

Conditions: Limited Stage Small Cell Lung Cancer

Summary: adriatic study explored the benefits of immune maintenance therapy after ls-sclc radiotherapy and chemotherapy. in the presence of immunotherapy, is it necessary to increase the dosage of radiotherapy and can it further improve the efficacy? this study aims to explore the efficacy and safety of simultaneous integrated boost hyperfractionation radiotherapy combined with probiotics and adalberg monoclonal antibody consolidation therapy for small cell lung cancer.


Eligibility criteria:
inclusion criteria: 1. sign written informed consent before implementing any experimental procedures; 2. age range: 18-80 years old; 3. pathological diagnosis of small cell lung cancer; 4. limited stage; 5. ecog ps 0-1； 6. receive ≤ 2 rounds of chemotherapy or chemotherapy plus immunotherapy; 7. expected survival time\>3 months; exclusion criteria: 1. progress after 2 induction treatments; 2. severe emphysema, interstitial changes in the lungs, copd patients; 3. resting blood oxygen\<93; 4. have a history of other malignant tumors and have received chemotherapy in the past 3 years; 5. history of chest radiotherapy;
body composition, bone mineral density, insulin sensitivity and echocardiographic measurements in klinefelter syndrome

Conditions: Klinefelter Syndrome; Diabetes; Osteoporosis; Metabolic Syndrome; Cardiovascular Disease

Summary: klinefelter syndrome (ks) is the most common sex-chromosome disorder with a prevalence of one in 660 men and is a frequent cause of hypogonadism and infertility. it is caused by the presence of extra x-chromosomes, the most common karyotype being 47,xxy. the phenotype is variable, but the most constant finding is small hyalinized testes, hypergonadotrophic hypogonadism, infertility, eunuchoid body proportion, increased height and learning disabilities. klinefelter syndrome has been associated with increased prevalence of diabetes, osteoporosis and cardiovascular diseases but the pathogenesis is unknown. accordingly the aim of the study was to investigate measures of body composition, insulin sensitivity, bone mineral density, echocardiography, as well as biochemical markers of endocrine, metabolic and bone function in ks and an age-matched control group.


Eligibility criteria:
inclusion criteria: * age above 18 years * verified ks karyotype (ks patients) exclusion criteria: * untreated hypothyroidism or hyperthyroidism * present or past malignant diseases * clinical liver disease * treatment with drugs knowing to interfere with glucose homeostasis, fat metabolism or bone modulation (e.g. glucocorticoids)
effectiveness of theraneem lip therapy for herpes simplex labialis

Conditions: Herpes Simplex

Summary: this study intends to test the efficacy of the theraneem lip therapy balm for herpes simplex. the study will include a total of 5 people.

qualified candidates will be officially enrolled into the study within 24 hours of their subsequent outbreak of herpes simplex labialis. they will be given all of the neem therapy products to use, and photographs and questionnaires will be taken to assess their progress.

Eligibility criteria:
inclusion criteria: 1. participant has signs and symptoms of hsv-1 infection of less than 24 hours duration to the southern california university of health sciences investigators 2. participants ages 18-70 years 3. confirmation of oral-circumoral herpes lesion will be made by a clinician in the presence of oral-circumoral lesion assumed to be hsv-1 for purposes of study 4. subjects expressed willingness to comply with protocol 5. subject will be willing to have the presenting lesion photographed twice 6. subject sign a written informed consent, hippa disclosure, experimental bill of rights exclusion criteria: 1. history of past or present immunosuppressive condition, or currently taking immunosuppressive medication 2. history of adverse effects or allergies to any neem based product or containing any of the other ingredients theraneem lip therapy: organic coconut oil, organic beeswax, organic jojoba oil, shea butter, sesame oil, organic neem oil, , essential oil of peppermint, vitamin e (tocopherol) 3. signs of disseminated hsv illness 4. history of use of oral or topical antiviral agents within 10 days of screening and/or at start of study visit 5. pregnancy or lactation 6. psychiatric disorder 7. inability to understand or follow the instructions
electroacupuncture and trancutaneous electrical nervous stimulation (tens) for colonoscopy analgesia

Conditions: Pain

Summary: to compare the effectiveness of acupuncture and transcutaneous electrical nervous stimulation (tens) in reducing patient's discomfort during colonoscopy

evaluation patient's pain and discomfort during colonoscopy, using two non invasive analgesic methods.

Eligibility criteria:
inclusion criteria: * all patients scheduled for colonoscopy and in whom deep sedation was not planned will be included in the study exclusion criteria: * age \> 80 and less than 18 years old, severe cardiac or pulmonary disease, anticoagulant, benzodiazepines, antidepressants, opiates therapies, severe cognitive impairment, uncontrolled hypertension.

Keywords: pain acupuncture transcutaneous electrical nerve stimulation colonoscopy
ms mosaic: a longitudinal research study on multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to better characterize the fluctuations in multiple sclerosis symptoms and their relationship to medications, to length/extent of disease, and to a variety of physiologic measures.


Eligibility criteria:
inclusion criteria: * be at least 18 years old * live in the united states of america * read/write in english exclusion criteria: * none
monotherapy with levetiracetam in newly diagnosed patients suffering from epilepsy

Conditions: Generalized Epilepsy

Summary: a double-blind trial comparing the efficacy and safety of levetiracetam to carbamazepine used as monotherapy in subjects (≥ 16 years) newly or recently diagnosed as suffering from epilepsy, and experiencing partial or generalized tonic-clonic seizures.


Eligibility criteria:
inclusion criteria: * subjects with newly or recently diagnosed epilepsy having experienced unprovoked partial seizures (ia, ib, ic with clear focal origin), or generalized tonic-clonic seizures (without clear focal origin), that are classifiable according to the international classification of epileptic seizures. the discrimination between ic and iie is not requested for inclusion. * subjects with at least 2 unprovoked seizures separated by a minimum of 48 hours in the year preceding randomization out of which at least 1 unprovoked seizure in the 3 months preceding randomization. * subjects with a confirmed diagnosis of epilepsy. * male/female subjects (≥16 years). exclusion criteria: * history or presence of seizures of other types than partial (ia, ib, ic, with clear focal origin) and generalized tonic-clonic (without clear focal origin) seizures. * history or presence of seizures occurring only in clustered patterns, defined as repeated seizures occurring over a short period of time, i.e. \< 20 minutes, with or without function regained between 2 ictal events. * history, clinical or eeg finding suggestive of idiopathic generalized epilepsy (ige) at randomization.

Keywords: monotherapy, epilepsy, levetiracetam, keppra.
the relationship between preoperative serum cytokine level and lenght of stay in hospital, postoperative pain intensity, functional status, joint position sense and x ray findings

Conditions: Total Knee Arthroplasty

Summary: serum cytokines was assosiated with symptoms and progression of osteoartritis. it is unknown whether these cytokines have a predictive role on severity of symptoms after total knee arthroplasty (tka) or not. the aim of this study is to investigate the relationships between the preoperative serum cytokine level (scl) and lenght of stay in hospital, postoperative pain intensity, functional status, joint position sense and x ray. grade 4 osteoartritis degeneration who intern the hospital for total knee arthroplasty surgery. serum cytokine levels (il-6, tnfα, il-1β) will be assessed before surgery. pain intensity at rest/activity and valgite angle will be evaluated before surgery, postoperative 72 hour and postoperative 6 weeks. functional status and joint position sense will be assessed before surgery and 6 weeks after surgery. lenght of stay in hospital (los) will be recorded.


Eligibility criteria:
inclusion criteria: 1. aged between 45-75 2. were scheduled for unilateral or bilateral tka 3. were diagnosed of oa with a severity grade 4 according to the kellgren-lawrence (kl) classification. exclusion criteria: 1. neuropathic pain 2. presurgery for same lower extremity 3. vascular disease 4. any chronic disease related to kidney, heart, liver 5. cancer 6. chronic inflammatory disease

Keywords: total knee arthroplasty cytokines proprioception pain functional status lenght of stay in hospital
prevalence of obesity hypoventilation syndrome

Conditions: Obesity Hypoventilation Syndrome

Summary: rationale of the "bio-ohs" study (prevalence of obesity hypoventilation syndrome): the overall prevalence of obesity hypoventilation syndrome (ohs) has never been directly assessed in the general population. actually, this prevalence has been assessed in patients referred to sleep clinics with a potential diagnosis of sleep-disordered breathing or in patients already diagnosed with sleep apnea. the purpose of this study is to determine the prevalence of obesity hypoventilation syndrome in obese patients referred to clinical laboratories for regular follow-up medical analysis.

no additional description

Eligibility criteria:
inclusion criteria: * 18 years old ans more * bmi over 30 kg/m2 * stable state (respiratory, metabolic and cardio-vascular) for the last 2 months * addressed to a clinical labs for a blood check-up whatever the prescription exclusion criteria: * no social security * non cooperative patient, as judged by the investigator

Keywords: obesity hypoventilation syndrome prevalence bicarbonate
comparing the efficacy and safety of a new additional treatment with tislelizumab in non-small cell lung cancer (nsclc)

Conditions: Non Small Cell Lung Cancer

Summary: the primary objective of this study is to evaluate and compare major pathological response(mpr) rate and event-free survival (efs) in participants receiving tislelizumab plus platinum-based doublet chemotherapy as the new additional treatment followed by tislelizumab as adjuvant treatment versus participants receiving placebo plus platinum-based doublet chemotherapy as neoadjuvant treatment followed by placebo as adjuvant treatment.


Eligibility criteria:
key inclusion criteria: 1. eastern cooperative oncology group (ecog) performance status of 0 or 1 2. histologically confirmed stage ii or iiia nsclc 3. measurable disease as assessed per recist v1.1 4. confirm eligibility for an r0 resection with curative intent key exclusion criteria: 1. any prior therapy for current lung cancer, including chemotherapy, or radiotherapy 2. known epidermal growth factor receptor (egfr) mutation or anaplastic lymphoma kinase (alk) gene translocation 3. any condition requiring systemic treatment with either corticosteroids (\> 10 mg daily prednisone or equivalent) or other immunosuppressive medications within 14 days before randomization 4. active autoimmune diseases or history of autoimmune diseases that may relapse 5. history of interstitial lung disease, non-infectious pneumonitis or uncontrolled diseases including pulmonary fibrosis, acute lung diseases, etc. note: other protocol defined inclusion/exclusion criteria may apply.
amnioexcel® plus vs a marketed comparator vs soc in the management of diabetic foot ulcers

Conditions: Diabetic Foot Ulcer

Summary: this is a multicenter, randomized, parallel-group study comparing the outcomes associated with the use of amnioexcel plus placental allograft membrane, a marketed comparator and soc alone in the management of diabetic foot ulcers (dfus).


Eligibility criteria:
inclusion criteria: 1. have participated in the informed consent process and signed a study-specific informed consent document. 2. be able and willing to comply with study procedures, including study visits, study dressing regimens, and compliance with study required offloading device. 3. be ≥ 21 years of age. 4. have type i or type ii diabetes mellitus with investigator-confirmed glycosylated hemoglobin (hba1c) of ≤ 12%. 5. have at least one diabetic foot ulcer ulcer size (i.e., area) is \> 1 cm2 and \< 12 cm2. 6. have adequate vascular perfusion of the affected limb exclusion criteria: 1. the subject was previously randomized and treated under this clinical study protocol. 2. the study ulcer has features that necessitates surgical operating-room debridement and/or penetrates to capsule/tendon/bone. 3. the subject is unable to safely ambulate with the use of a study required offloading boot. 4. the subject has suspected or confirmed gangrene or wound infection of the study ulcer. 5. the subject has suspected or confirmed osteomyelitis. 6. in the opinion of the investigator, the subject has received or is scheduled to receive during study participation, a medication or treatment which is known to interfere with or affect the rate and quality of wound healing 7. the subject has a history of bone cancer or metastatic disease of the affected limb, radiation therapy to the foot, or has had chemotherapy prior to signing the informed consent form for trial participation. 8. the subject is currently pregnant or is actively trying to conceive. 9. in the opinion of the investigator, the subject is unable to comply with the treatment regimen 10. in the opinion of the investigator, the subject has a history of, or is currently diagnosed with, any illness or condition, other than diabetes, that could interfere with wound healing. 11. in the opinion of the investigator, the subject has a condition that could inhibit wound healing. 12. the subject has ulcers secondary to a disease other than diabetes.
extension to the magnify ms trial on mavenclad® (magnify ms extension)

Conditions: Multiple Sclerosis

Summary: the primary purpose of this study was to evaluate the long-term effectiveness of mavenclad® tablets, in terms of disease activity and safety, in participants with highly-active relapsing multiple sclerosis (rms) previously participating in the magnify ms trial ms700568_0022 (nct03364036).


Eligibility criteria:
inclusion criteria: * participants of the magnify multiple sclerosis (ms) trial who received at least a single dose of cladribine tablets during the magnify ms trial and data on magnetic resonance imaging (mri) is available/acquired from at least parent study month 18 or month 24 visit and expanded disability status scale (edss) and relapse from parent study month 24 visit * capable of giving signed informed consent exclusion criteria: * participant is considered by the investigator, for any reason, to be an unsuitable candidate for the study * participation in other studies/trials

Keywords: multiple sclerosis mavenclad ® cladribine relapsing multiple sclerosis immune cell kinetics
evolution of walking abilities in subacute stroke patients hospitalized in neurorehabilitation center

Conditions: Stroke; Gait, Hemiplegic

Summary: the goal of this observational study is to describe the evolution of gait recovery during the subacute phase of stroke up to six months after stroke, in patients hospitalized in medical and neurological rehabilitation units.


Eligibility criteria:
inclusion criteria: * patient hospitalized in one of the investigating centers after acute/subacute stroke. * affiliated to a social security scheme exclusion criteria: * opposed to its participation in this study * neurodegenerative disease impacting gait prior to stroke onset * patient not walking before stroke * progressive pathology with life-threatening consequences within 6 months * patient under legal protection

Keywords: stroke lower limb gait recovery balance
hostility and pathogenic mechanisms of coronary heart disease in women

Conditions: Cardiovascular Diseases; Coronary Disease; Heart Diseases

Summary: to determine the combined effects of hostility, harassment, lipids, and oral contraceptive (0c) use on physiological responses in young and middle-aged premenopausal women.

background: preliminary findings already have shown that, in contrast to women with low scores on the cook and medley hostility (ho) scale, women with high ho scores exhibit greater cardiovascular changes to harassment. additional findings have suggested that oral contraceptive (0c) use may also be associated with increased behaviorally-induced physiological changes, especially in low ho women. similarly, higher levels of total serum cholesterol (tsc) have been positively associated with greater stress-induced neurohormonal changes in middle-aged men with high ho scores. design narrative: assessment of autonomic activity took place in the laboratory and during a 24 hour ambulatory measurement period. hostility was measured with the cook and medley hostility scale. the laboratory assessment helped to determine if high hostility women responded to harassment with greater cardiovascular and neurohormonal changes than low hostility women, and if this relationship was altered by 0c use, lipids, and age. the ambulatory assessment of autonomic activity allowed an exploration of the responses of high and low hostility subjects to daily-life stressors. several hypothesis were explored: 1) did harassment produce neuroendocrine as well as cardiovascular hyperreactivity in young women, and did this hyperreactivity generalize from laboratory to real-life? 2) were the harassment-induced cardiovascular and neuroendocrine changes in young women also present in middle-aged women? 3) to what extent did 0c use modulate the cardiovascular and neuroendocrine responses to harassment in young women, and was 0c use also altering the hostility--related associations between lipids and reactivity? 4) were the differential lipid-reactivity associations observed in middle-aged men as a function of high and low hostility scores present in women, and, if so, were they modulated by age? the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria