Kornimate/medical-research-clean huggingface dataset:
randomized controlled study of programmed weaning from niv for aecopd

Conditions: Acute Exacerbation of COPD

Summary: purpose of research:to explore a reasonable programmed withdrawal process of noninvasive ventilation and thereby reduce the duration of noninvasive mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease.

this is a single-center, prospective, randomized controlled study. the study subjects were patients with acute exacerbation of chronic obstructive pulmonary disease admitted to the intensive care unit, who were randomized into the study group, that is, the programmed withdrawal unit, and the control group was the traditional withdrawal unit (the attending physician decided the niv regimen according to the condition). the primary study endpoints of the trial were complete evacuation of noninvasive ventilation (i. e. from the start of the patient to noninvasive ventilation) or return of time to normal ventilation for patients with a home non-invasive ventilator prior to acute exacerbation. secondary study endpoints include length of stay, stay and failure of non-invasive ventilation (failure of non-invasive ventilation was defined as the patient requiring endotracheal intubation to invasive ventilation or death).

Eligibility criteria:
inclusion criteria: * it is defined that in patients with acute exacerbation of chronic obstructive pulmonary disease, the arterial blood gas analysis was decompensation of respiratory acidosis, and the ph value was 7.20-7.35 * non-invasive mechanical ventilation was performed and it was well tolerated exclusion criteria: * younger than 40 years old * pregnancy * human immunodeficiency virus (hiv) antibody was positive * hemodynamic instability * mechanical ventilation for endotracheal intubation and cardiopulmonary resuscitation were disagreed

Keywords: noninvasive mechanical ventilation
a study to evaluate the safety and efficacy of celgosivir in patients with chronic hepatitis c genotype 1 infection

Conditions: Hepatitis C, Chronic

Summary: the objective of the study is to evaluate the safety and efficacy of celgosivir for 12 weeks in patients with chronic hepatitis c genotype 1 infection.


Eligibility criteria:
inclusion criteria: * the patient must be 18 to 65 years of age, inclusive. * primary diagnosis of chronic hcv infection. exclusion criteria: * patients who did not respond or relapsed following therapy with interferon.

Keywords: hepatitis c celgosivir hcv genotype 1
six years of follow-up after idiopathic venous throbmoembolism

Conditions: Pulmonary Embolism; Proximal Deep Vein Thrombosis

Summary: beyond the first 6 months of anticoagulation, patients with a first episode of unprovoked venous thromboembolism have a high risk of recurrence after stopping anticoagulations. extending anticoagulant therapy for an additional 18 months is associated with a major reduction of recurrent vte; however this benefit tended to be lost after stopping anticoagulation during a follow-up period of two years. this risk of recurrentce is likely to continuously increase over the years as well as the risk of chronic thromboembolic pulmonary hypertension (after pulmonary embolism) or the risk of post-thrombotic syndrome (after deep vein thrombosis). the aim of the padis-extension trial is to estimate these risks over 6 years of follow-up in patients who have been initially treated during 6 months or 24 months (patients included in the padis pe and padis dvt trial).

beyond the first 6 months of anticoagulation, patients with a first episode of unprovoked venous thromboembolism have a high risk of recurrence after stopping anticoagulations (about 10% at one year and 30% at 5 years). extending anticoagulant therapy for an additional 18 months is associated with a major reduction of recurrent vte; however this benefit tended to be lost after stopping anticoagulation during a follow-up period of two years. this has been well demonstrated in the double-blind randomized padis pe trial comparing 2 years with 6 months of anticoagulation and a follow-up of two years after study treatment discontinuation. this risk of recurrence is likely to continuously increase over the years as well as the risk of chronic thromboembolic pulmonary hypertension (after pulmonary embolism) or the risk of post-thrombotic syndrome (after deep vein thrombosis). in addition, risk factors of such complications remain uncertain. the first aim of the padis-extension trial is to estimate these risks over 6 years of follow-up in patients who have been initially treated during 6 months or 24 months (patients included in the padis pe and padis dvt trial). secondary aims are to identify risk factors of these complications during long-term follow-up.

Eligibility criteria:
inclusion criteria: * patients with a first episode of idiopathic pulmonary embolism or idiopathic proximal deep vein thrombosis who have been initially treated during 6 months or 24 months using vitamin k antagonist with a inr between 2 and 3 and enrolled in clinical study padis-ep and padis tvp exclusion criteria: participation refused

Keywords: venous thromboembolism recurrent venous thromboembolism anticoagulant-related bleeding
correlation between the 'nine holes peg test' performance and the triple stimulation technique within a group a patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the main goal of this study is to determine if the triple stimulation technique (tst) can be correlated to performance in the manual dexterity 'nine holes peg' test, within a control group and a group of patients with multiple sclerosis. tst (triple stimulation technique) combines two techniques used in neurologic diagnosis: magnetic stimulation and electroneuromyography. it is based on the principle of two collisions between the descending central stimulation (magnetic stimulation) and the ascending peripheric stimulation. tst allows to better quantify central nervous system diseases. the abnormal amplitude registered by tst is proportional to the intensity of conduction disorders. the evaluation of these disorders is more precise than with the magnetic stimulation technique alone. the nine hole pegs technique is a simple manual dexterity test, commonly used in ergotherapy. the participant tries to place 9 pegs in a 9 holes perforated plate, and then tries to remove them as quickly as possible. the hand must stay in a depression within the plate, thereby insuring a constant distance between the hand and the pegs. the nine hole peg will be realized first, and the triple stimulation examination performed after. the acquired data will be analyzed in order to find a correlation between the impairment level given by these two tests.


Eligibility criteria:
inclusion criteria: control group: * no history of neurological disease * no medicines intake that could disturb performance within the tests (psychotropic medications, sedatives, anti spastic and drugs acting on neuromuscular transmission). multiple sclerosis group * multiple sclerosis diagnose. patients followed by dr dachy, within the chu brugmann hospital. exclusion criteria: * persons carrying ferromagnetic material (implants, pacemaker). * epilepsy history. * patients who have had a head trauma with loss of consciousness and/or brain injury. * pregnant woman.

Keywords: nine holes peg triple stimulation multiple sclerosis
clinical study on the treatment of systemic sclerosis with utaa91 injection.

Conditions: Systemic Sclerosis (SSc)

Summary: this clinical trial is designed as a single-arm, open-label, single-center investigator-initiated early-phase study, with the primary objective of evaluating the safety of utaa91 injection in subjects with refractory moderate-to-severe active systemic sclerosis.


Eligibility criteria:
inclusion criteria: * aged ≥18 years (inclusive of the boundary value), with no restriction on gender. * expected survival time of ≥3 months. * refractory moderate - to - severe active systemic sclerosis that has failed standard treatment or lacks effective therapeutic options. * meets the requirements for liver and kidney function, as well as cardiopulmonary function. * free from severe psychiatric disorders. * able to understand the trial and has signed the informed consent form. exclusion criteria: * a history of malignant tumors other than relapsed/refractory autoimmune diseases (r/r aid) within 5 years prior to screening. * positive results in virology/syphilis tests. * severe cardiac diseases or unstable systemic diseases. * presence of active or uncontrollable infections requiring systemic treatment, or evidence of central nervous system invasion. * pregnant or breastfeeding women, female subjects planning to become pregnant within 2 years after cell infusion, or male subjects whose partners plan to become pregnant within 2 years after their cell infusion. * subjects who have received car - t therapy or other gene - modified cell therapies prior to screening. * subjects who participated in other clinical studies within 1 month prior to screening. * other conditions deemed unsuitable for enrollment by the investigator.
feasibility study for online mindfulness for gad

Conditions: Anxiety Generalized

Summary: method: . forty patients with general anxiety disorder will be randomized in 1:1 ratio to the online resource plus usual care, and to usual care control group by stratified block randomization. measurements including 7-item generalized anxiety disorder questionnaire, 9-item patient health questionnaire, penn state worry questionnaire, and five facet mindfulness questionnaire will be made at baseline and at 2-month. rate of recruitment, drop out and website usage will be collected. all patients in the intervention arm will be interviewed to assess the clarity of the app and user experience. the scores between the two arms will be compared by t-test and the transcripts of the patient interviews will be analysed using thematic analysis


Eligibility criteria:
inclusion criteria: * received a diagnosis of gad in the computerized record system (cms) in hong kong hospital authority * score ≥10 on the 7-item generalized anxiety disorder scale (gad-7), signifying active moderate anxiety symptoms * used any website in prior 12 months * received stable dose of psychoactive medications in last 2 months exclusion criteria: * any diagnosed psychotic disorder * diagnosis of dementia * any diagnosed substance abuse disorder (except smoking) * active suicidal ideation (score ≥1 on 9-item patient health questionnaire * had regular mindfulness meditation practice in last 6 months or had participated in mbsr/mbct course
safety, tolerability and immunogenicity of meningococcal b recombinant vaccine administered as booster dose at 12, 18 or 24 months of age in toddlers (12-24 months) primed with a three-dose immunization series as infants in study v72p12

Conditions: Meningococcal Disease; Meningococcal Meningitis

Summary: this extension study v72p12e1 will investigate the safety, tolerability and immunogenicity of a fourth (booster) dose of rmenb+omv nz at 12, 18 and 24 months of age in subjects previously primed with rmenb+omv nz according to two different three-dose immunization schedules in infancy (2, 4 and 6 or 2, 3 and 4 months of age in the parent study v72p12). the study will also explore the bactericidal antibody persistence at 12, 18 and 24 months of age, following the two different immunization schedules, in order to identify the optimal timing for boosting. two catch-up rmenb+omv nz doses will be given to unprimed, naïve toddlers at 12 (subjects enrolled in the control group of v72p12), 18 and 24 months of age (two new cohort of subjects enrolled). these subjects will generate data for assessing the safety and immunogenicity of a two-dose catch-up regimen at these ages, but will also serve as controls for a descriptive comparison of antibody persistence and booster responses for the other groups.


Eligibility criteria:
inclusion criteria: follow-on participants of v72p12: healthy toddlers who completed study v72p12, aged: * 12 months or older - groups 1a, 2a, 3a, 4 * 18 months (0/ +29 days window) - groups 1b, 2b, 3b * 24 months (0/ +29 days window) - groups 1c, 2c, 3c naive subjects newly enrolled: * group 5: healthy 18-month-old toddlers (0/ +29 days window) * group 6: healthy 24-month-old toddlers (0/ +29 days window) exclusion criteria: * history of any meningococcal b vaccine administration (only for groups 5 and 6); * previous ascertained or suspected disease caused by n. meningitidis; * history of severe allergic reaction after previous vaccinations or hypersensitivity to any vaccine component; * significant acute or chronic infection within the previous 7 days or axillary temperature major or equal to 38 degrees within the previous day * antibiotics within 6 days prior to enrollment; * any serious chronic or progressive disease; * known or suspected impairment or alteration of the immune system; * receipt of blood, blood products and/or plasma derivatives or any parenteral immunoglobulin preparation.

Keywords: meningococcal meningitis prevention vaccination toddler
respiratory training in patients with leukemia

Conditions: Leukemia

Summary: forty male leukemic patients receiving chemotherapy were selected from national cancer institute, they were randomly assigned into two groups. group (a) included 30 patients who were trained by inspiratory muscle trainer for 4 weeks ;5 sessions/week and group (b) included 10 patients as a control group. the following measures were taken before and after the study period : maximum voluntary ventilation(mvv) , 2 min walk test, fact-g questionnaire

forty male leukemic patients receiving chemotherapy for at least one cycle and their mean ages 37.1 ± 4.89 years.the patients were selected from national cancer institute, cairo ( inpatient ward). the study lasted from march 2018 to june 2018. patients were randomly assigned into two groups.group a (30 patients) who received inspiratory muscles training for 4 successive weeks, 5 sessions/week; and group b (10 patients) acted as a control group on chemotherapy only. data obtained from both groups regarding (mvv), 2 min walk test and quality of life questionnaire (fact-g) were statistically analyzed and compared

Eligibility criteria:
inclusion criteria: * male patient with age ranges from 30-50 years * all patients were leukemic receiving chemotherapy for at least one cycle as a treatment of malignant tumor * all patients were hemodynamically stable * all patients were ambulant exclusion criteria: * lung cancer * history of any pulmonary disease. * metastasis of lungs, ribs, mediastinal structure * pulmonary pathology(e.g acute respiratory distress syndrome or exacerbation of chronic obstructive pulmonary disease) * ruptured ear drum or any other condition of the ear * high peak airway pressure (barotraumas) * patients with marked elevated left ventricular end diastolic volume and pressure * patients with worsening heart failure signs and symptoms

Keywords: leukemia chemotherapy respiratory training
effect of probiotic's consumption on several markers in perforated appendix patients with diffuse peritonitis

Conditions: Appendicitis with Perforation; Appendectomy; Probiotic

Summary: does the administration of the probiotic lactobacillus plantarum sp. have an impact on reducing leukocyte levels, segmented neutrophil counts, postoperative pain, and length of hospitalization in patients with diffuse peritonitis caused by perforated acute appendicitis who underwent laparotomy appendectomy at dr. hasan sadikin hospital?

to determine whether the administration of the probiotic lactobacillus plantarum sp. to patients with diffuse peritonitis caused by appendiceal perforation undergoing laparotomy appendectomy at hasan sadikin hospital bandung and siloam karawaci hospital has a significant effect on leukocyte levels, segmented neutrophil counts, postoperative pain levels, and length of hospitalization compared to the placebo group.

Eligibility criteria:
inclusion criteria: * patients diagnosed with diffuse peritonitis caused by appendicitis * patients undergoing laparotomic appendectomy. * patients aged 18 years or older. exclusion criteria: * patients with a history of previous laparotomy. * patients who underwent laparotomy combined with surgery on other parts of the body. * patients with a history of cancer. * patients with pre-existing comorbidities (uncontrolled diabetes mellitus, congestive heart failure, end-stage renal disease \[esrd\], human immunodeficiency virus \[hiv\], and systemic lupus erythematosus \[sle\]). * patients with multiple organ dysfunction syndrome (mods). * patients with prior consumption of probiotics.

Keywords: perforated appendicitis appendectomy probiotic laparotomy
effects of antihypertensive drugs in patients with hypertension and obstructive sleep apnea (osa)

Conditions: Obstructive Sleep Apnea; Hypertension

Summary: the aim of the present study is to compare the effects of different types of antihypertensive drugs (angiotensin ii receptor blockers and long-acting calcium channel blockers) in patients with hypertension and obstructive sleep apnea who are not controlled well with their hypertension after continuous positive airway pressure therapy.

obstructive sleep apnea (osa) and hypertension have a significant interrelationship, and both disorders are well known risk factors for cardiovascular diseases (cvd). treating them appropriately may improve the prognosis of the patients. presently, continuous positive airway pressure (cpap) therapy is the first-line therapy for osa, and angiotensin ii receptor blockers and long-acting calcium channel blockers for hypertension in japan. therefore, in the present study, we wanted to compare the effects of these different types of antihypertensive drugs on the control of blood pressure in patients with osa whose hypertension is not controlled well after cpap therapy.

Eligibility criteria:
inclusion criteria: * apnea and hypopnea index of more than 20 /hr, and treated with cpap * uncontrolled hypertension (defined as systolic blood pressure of more than 130 mmhg or diastolic blood pressure of more than 80 mmhg exclusion criteria: * cerebrovascular diseases, myocardial infarction, angina pectoris or heart failure within 6 months * uncontrolled arrhythmia * severe hepatic or renal disorders * having poor prognosis disorders such as malignant disorders

Keywords: continuous positive pressure ventilation blood pressure oxygen desaturation index endothelial dysfunction patient reported measurement
sexual dysfunction and adaptation in couples affected by prostate cancer surgery

Conditions: Prostate Cancer; Erectile Dysfunction Following Radical Prostatectomy; Sexual Dysfunction

Summary: the purpose of this study is to explore patient and partner experiences with sexual dysfunction following radical prostatectomy, in order to understand its effects on sexual and non-sexual intimacy. this will enable us to provide assistance in the future to individuals experiencing similar circumstances.

we are studying the impact of sexual dysfunction following radical prostatectomy on patient and partners' experiences of intimacy. research with men in post-radical prostatectomy recovery indicates 25%-75% experience sexual dysfunction. many patients experience anxiety and distress related to sexual difficulties. these experiences may progress and result in long-term problems in the relationship between patients and their partners. despite apparent levels of effectiveness, up to half of the patients who turn to sexually assistive aids after surgical removal of the prostate discontinue use of the aids within one year. additionally, difficulties in communicating about sexual impairments can significantly interfere with the couples' ability to achieve successful adaptation. we are interested in studying patient and partner experiences with sexual dysfunction in order to understand its effects on sexual and non-sexual intimacy. participation in this study will involve completing 6 confidential face-to-face interviews on three separate occasions (3-6 months, 12-15 months, and 21-24 months post-surgery). on each occasion, participants will be required to take part in a "couple's" interview with his/her partner, as well as an individual interview. the interviews will provide participants with the opportunity to discuss the impact of sexual dysfunction on mood, thoughts, and communication with their partners. demographic information will be collected at the initial interview. as well, at each of the 3 time points, participants will also be asked to complete a questionnaire package containing 6 psychological questionnaires. all questionnaires and interview material will be kept strictly confidential.

Eligibility criteria:
inclusion criteria: * radical prostatectomy treatment for prostate cancer at princess margaret hospital or etobicoke general hospital * at least 3 months, but less than 6 months post-radical prostatectomy * experience sexual dysfunction as a result of radical prostatectomy * must have an intimate partner and be able to participate as a couple exclusion criteria: * detectable prostate specific antigen (psa) post-radical prostatectomy * patient or partner unable to speak english * patient or partner unwilling to allow interviews to be recorded * patient or partner unwilling to participate

Keywords: prostate cancer radical prostatectomy sexual dysfunction intimacy adaptation psychosocial oncology
intracranial pressure after decompressive craniectomy

Conditions: Traumatic Brain Injury; Middle Cerebral Artery Stroke; Intracranial Hemorrhages; Intracranial Hypertension

Summary: observational study to investigate the natural course of intracranial pressure (icp) after decompressive craniectomy (dc) using long-term telemetric icp monitoring. patients will have continuous icp measurement performed during the admission to the neuro-intensive care unit (nicu) and after discharge weekly measurements sessions will be performed before and after cranioplasty.

several studies have investigated and documented the effect of dc in lowering icp in intracranial hypertension following acute brain injuries, e.g. severe traumatic brain injury. but the natural course of icp in these patients after the acute phase in the nicu has never been investigated. clinical experience suggests that a dc affects cerebrospinal fluid circulation and icp, e.g. causing hydrocephalus or subdural hygromas. the aim of this observational study is to document the natural course of icp following dc and to investigate the effect of cranioplasty on icp. this is done by implantation of a telemetric icp sensor and weekly follow-up monitoring sessions after discharge from the nicu until 1 month after cranioplasty. the monitoring sessions will include standardized body positions to investigate postural icp changes before and after cranioplasty. the project will also provide experience with telemetric icp monitoring during the acute phase in a nicu setting.

Eligibility criteria:
inclusion criteria: * age \> 18 years * scheduled for a decompressive hemicraniectomy for elevated icp or signs of intracranial herniation exclusion criteria: * skin damage in the frontal area where the telemetric icp sensor is implanted * lack of informed consent from next-of-kin or the patient's general practitioner

Keywords: decompressive craniectomy intracranial pressure icp telemetry telemetric