Kornimate/medical-research-clean huggingface dataset:
radiomic modeling in differentiating uncomplicated from complicated acute appendicitis

Conditions: Acute Appendicitis

Summary: non-operative management (nom) with antibiotics may be a safe alternative to surgery for uncomplicated appendicitis, but preoperative differentiation between uncomplicated and complicated appendicitis is challenging. the study aimed to develop a clinical-radiomics nomogram to distinguish uncomplicated from complicated appendicitis.


Eligibility criteria:
inclusion criteria: * pathologically diagnosed as acute appendicitis after appendectomy between january 2021 and december 2022. exclusion criteria: * age less than 18 years (no upper age limit); * without ct examination within a week before surgery; * difficult to outline the contours of the appendix due to inflammatory exudate; * lack of clinical information.

Keywords: acute appendicitis diagnosis nomogram
integrated supported employment in mainland china

Conditions: Schizophrenia

Summary: in this randomized controlled trial, the researchers investigated the effectiveness of integrated supported employment (ise) as compared with individual placement and support (ips) and traditional vocational rehabilitation (tvr) for people with schizophrenia in mainland china.

one hundred and sixty-two participants with schizophrenia were randomly assigned to ise (n = 54), ips (n = 54), and or tvr (n = 54). blinded assessments of employment status, job tenure, and psychological outcomes were conducted at admission, completion of the 3-mo program, and follow-up at 7, 11, and 15 mo.

Eligibility criteria:
inclusion criteria: * aged 18 years or older; * diagnosis of schizophrenia for at least 2 years * being unemployed * willing to give informed consent * having no obvious cognitive, learning, or neurological impairment * having completed primary school education * having a desire to work exclusion criteria: • having score lower than 18 on the 30-item mini-mental state examination
burnout among adolescent population during covid-19 lockdown in pakistan

Conditions: Burnout, Psychological; Covid-19 Pandemic

Summary: the lethal severe acute respiratory syndrome coronavirus 2 (sars-cov2) which caused the covid-19 pandemic starting at the end of 2019 has affected the lives of children and adolescents globally. world adopted the lockdown to prevent spread of the infection and protect the population. lockdown suspended out of home activities of almost everyone, along with health benefits, yielding some side effects as well including burnout. the burnout includes physical and emotional burnout, physical burnout refers to the lack of interest in any physical activity to the point of a rebel and the emotional burnout of teenagers refers to a syndrome including features such as behavior changes, thinking change, feeling change, health change leading to stress and other pathological disturbances. together the external and internal factors lead to overall personality destruction. it was an observational study with a sample size of 443 participants.

objective of the study was to analyze the change in behavioral patterns, its impact, and peer pressure caused by lockdown during pandemic covid-19 among the adolescent population of sialkot pakistan. it was an observational study with a sample size of 443 participants. the study was conducted after ethical approval by institutional review board, sialkot college of physical therapy wide reference no. scpt-irb-dpt-129-2020 dated 01-09-2020. data were collected from different institutions in sialkot, pakistan. the target population of our study was adolescents of age 13-19 years. regression analysis was done to find the predictor factors mobile use and covid-19 lockdown on the dependent variable the burnout score. the correlation was applied among mobile phone use, lockdown, and burnout score.

Eligibility criteria:
inclusion criteria: * students of the above age group who started to go to the school/ colleges/ university/academies. * those who consent to participate in the study. exclusion criteria: * students who were unable to visit their institution and stayed at home.

Keywords: adolescent population covid-19 pandemic burnout mental health
pulmonary rehabilitation in patients suffering from post-pe syndrome

Conditions: Pulmonary Embolism

Summary: this study is a multicenter, parallel, randomized waitlist-controlled trial that primarily focuses on the short-term benefit of outpatient pulmonary rehabilitation (pr) on patients after acute pulmonary embolism. patients will be randomized into an intervention and a control group. the intervention group will receive 6 weeks of outpatient pr, while patients in the other treatment arm will serve as a control. after completion of the randomized study, the second arm will undergo pr as well.


Eligibility criteria:
inclusion criteria: * post-pe syndrome (except patients previously diagnosed with cteph) diagnosed by any of the following: * post-pe functional impairment criteria * post-pe cardiac impairment criteria * chronic thromboembolic disease criteria * possibility of starting rehabilitation between 12 and 36 weeks after the initial event of pe exclusion criteria: * cteph diagnosis * chronic pulmonary diseases: copd, interstitial lung diseases, asthma (only patients with severe asthma defined as a fev1 ≤ 80% will be excluded), a statement on covid-19 was amended due to the pandemic # * active cancer * pregnancy * myocardial infarction or cardiac surgery one year prior to inclusion * congenital heart disease, congestive heart failure * history of stroke * any previous inpatient or outpatient pr additional criteria that are absolute contraindications for pulmonary rehabilitation * acute and decompensated disease states with severe functional restrictions of various organ systems (e.g. heart, kidney and liver insufficiency, unstable angina pectoris, hemodynamically unstable arrhythmias, acute spinal cord injury, untreated hormonal disorders, acute psychological disorders) * open tuberculosis * active infectious diseases and acute inflammatory processes * stressful and time-consuming therapy that significantly impair the ability to rehabilitate (e.g. chemotherapy or radiation therapy after malignancy) * participants who are not sufficiently resilient due to physical or mental impairment and / or cannot be mobilized and therefore cannot actively use the rehabilitation facility * lack of motivation for therapy * massive incontinence * drugs and alcohol addiction

Keywords: pulmonary rehabilitation exercise training pulmonary embolism
the changing panorama in risk factors of cerebral palsy

Conditions: Cerebral Palsy

Summary: the study will be carried of scanning the database of 296 individuals with cerebral palsy followed in the university pediatric rehabilitation clinic. cerebral palsy risk factors and demographic information will be obtained from the database. the data will be classified according to date of birth, divided into 3 groups: those born before 2000, those born between 2000-2010, and those born after 2010.changes in cerebral palsy risk factors will be investigated at 10-year intervals.

the study will be carried of scanning the database of 296 individuals with cerebral palsy followed in the university pediatric rehabilitation clinic. cerebral palsy risk factors and demographic information will be obtained from the database. cerebral palsy subtypes classified according to the surveillance for cerebral palsy in europe (scpe) classification into four groups: spastic (unilateral and bilateral), dyskinetic (dystonic and choreoathetoic), ataxic/hypotonic, non-classifiable. cerebral palsy risk factors will be primarily divided into 4 as preconceptional, antenatal, intrapartum and neonatal risk factors. then, risk factors in the data will be distributed to the appropriate risk factor group. the data will be classified according to date of birth, divided into 3 groups: those born before 2000, those born between 2000-2010, and those born after 2010. changes in cerebral palsy risk factors will be investigated at 10-year intervals.

Eligibility criteria:
inclusion criteria: * cerebral palsy patients exclusion criteria: * missing data on the cerebral palsy database

Keywords: cerebral palsy etiology risk factors low birth weight prematurity
effectiveness of active video games in children with intellectual disabilities

Conditions: Intellectual Disability

Summary: background: children with intellectual disabilities (id) are more vulnerable to obesity when compared to the normal children (getchell et al., 2012; maiano, 2011). active video games (avgs) on physical activity (pa) behavior have attracted academic interest and exploration since 2000. it has been demonstrated that an intervention with avgs is compatible with the school setting and behavioral change in health and pa (lau, et al., 2015). however, special populations such as id children and their needs have been neglected in this area (martins, carvalho \& soares, 2011). id children's pa behavior, motor ability and physical fitness is still an under-explored area. aims: to determine the effect of a prescribed avg intervention on id children's pa levels (sedentary, light, moderate, and vigorous), motor ability, and physical fitness. the intervention effects in children with mild intellectual disability will be explored. design: a standard two-arm parallel, single-blinded, randomized control cluster trial. schools: participants will be recruited from six special schools in hong kong. schools with same intellectual disability categories will be randomly assigned into intervention group and control group. participants: 200 children aged 8\~18 years old with intellectual disabilities will be recruited. intervention: id children randomized to the intervention group will participate in an avg intervention 60 minutes per week for 12 weeks in their pe class, in addition to their usual activity levels. the research team will prescribe updated avg consistent with moderate-vigorous intensity. control: the control group will continue with usual pa alone and will not receive the avg intervention. analysis: repeated measures mixed model (2 groups x 2 time points (12-week post- test and 8-week follow up test)) by spss 23.0 will be used to investigate the intervention effect on primary and secondary outcomes, adjusting for baseline characteristics and correlation between repeated observations. significance: this will be the pioneering study to provide definitive evidence for the impact of a prescribed avg intervention on id children's pa level, motor ability and physical fitness. if effective, this research will provide significant evidence from the innovative method to inform health professionals and pe teachers how to incorporate avg to enhance physical active behaviors, motor ability and physical fitness in id children. finally they may be able to enjoy a better quality of life.


Eligibility criteria:
inclusion criteria: * students with id (mild category) aged 8-18 years old from special education schools including primary and secondary schools; exclusion criteria: * students without physical disability.

Keywords: exergame children with intellectual disability physical activity motor proficiency
comparison of tiotropium inhalation capsules and oxitropium metered dose inhalator (mdi) in patients with chronic obstructive pulmonary disease (copd)

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: the objective of this study is to investigate the long-term safety of ba 79 br (tiotropium) powder inhalation in patients with copd using oxitropium bromide (tersigan) as a comparator. secondarily, the long-term efficacy of ba 679 br is also investigated


Eligibility criteria:
inclusion criteria: the patients with copd (chronic bronchitis, emphysema) whose symptoms are stable and who satisfy the following criteria 1. patients with fev1.0 of \<=70% of predicted normal and fev1.0/fvc of \<=70% in the screening test (the fev1.0 value should also be \<=70% of predicted normal on the starting day of administration (visit 2).) 2. patients with a smoking history (\ is \>=200.) 3. male or female patients aged \>=40 years old exclusion criteria: 1. patients complicated with bronchial asthma, making the assessment of drug efficacy against copd difficult 2. patients using oral corticosteroid medication at a dose in excess of the equivalent 10 mg/day of prednisolon 3. patients with glaucoma 4. patients with symptomatic prostatic hypertrophy 5. patients with hypersensitivity to anticholinergic drugs or powder inhalants 6. patients with serious complication who are judged by the investigator to be inappropriate as the subjects of study 7. patients demonstrating clinically problematic abnormal laboratory test values (general blood test, biochemical test, urinalysis). those showing glutamic oxaloacetic transaminase (got) and glutamic pyruvictransaminase (gpt) twice the upper limit of the normal range, bilirubin 1.25 times or creatinine 1.25 times of the upper limit of normal range are excluded. 8. patients with a recent history of myocardial infarction or heart failure (i.e. within 3 months before the screening test) 9. patients with arrhythmia requiring the treatment with drugs 10. patients for whom the concomitant use of beta-blocker cannot be prohibited. 11. patients who began treatment with an ace inhibitor within 1 month before the screening test 12. patients with tuberculosis (currently active) or with definite sequela of tuberculosis 13. patients with a recent history of carcinoma (excluding basal cell carcinoma) (i.e. within the past 5 years) 14. patients with a history of cystic fibrosis and bronchiectasis 15. patients with recent onset of upper airway infection (i.e. within 1 month before the screening test) 16. patients who have taken an investigational drug within one month or within period six times of half-lives of that drug (whichever is longer) before the screening test. 17. women who are pregnant or who may become pregnant, or those breast feeding 18. other than above, those who are judged by the investigator to be inappropriate as the subjects of study
examining the effects of vivo on physical function and glycemic level in sedentary older with prediabetes.

Conditions: PreDiabetes; Older Adult; Muscle Loss; Muscle Weakness

Summary: this is a 12-week randomized, controlled trial that seeks to examine the effect of vivo on 1) change in lower extremity strength defined as number of chair stands done in 30 seconds and 2) change in average glycemic level (hba1c) compared to a wait list control.

this is a 12-week randomized, controlled trial that seeks to examine the effect of vivo on 1) change in lower extremity strength defined as number of chair stands done in 30 seconds and 2) change in average glycemic level (hba1c) compared to a wait list control. after informed consent and baseline assessments, up to 90 individuals will be randomized in one of two arms: 1) vivo intervention or 2) waitlist control. participants in the vivo 2.0 intervention arm will meet virtually twice a week with their small group and certified trainer for 45 minutes over a 12-week period. participants will be men and women, ≥60 years old, sedentary, with prediabetes and low function. all participants will undergo baseline and 12-week assessments

Eligibility criteria:
inclusion criteria: * age ≥ 60 years * ambulatory and community-dwelling * diagnosis of pre-diabetes within prior 12 months: fasting glucose between 100 to 126 or hba1c between 5.7 and 6.4% * low functioning: 1) able to do at least 1 chair stand and 2) number of chair stands done in 30 seconds is below criterion-referenced fitness standards for maintaining physical independence for age and gender * sedentary: less than 150 minutes of moderate physical activity or less than 60 minutes of vigorous physical activity per week * have not engaged in resistance training for at least 6 months prior to enrollment * access to wifi in defined exercise space exclusion criteria: * inability to complete physical function assessment * use of antidiabetic medications * use of testosterone supplement or replacement * clinical disorder precluding/interfering with participation of assessments * unstable angina, arrhythmia, uncontrolled hypertension * end stage renal disease on hemodialysis * lower extremity amputation or paralysis * neurological condition causing functional or pronounced cognitive impairments * active malignancy except for non-melanomatous skin cancers * weight instability (defined as gain or loss of ≥10% over the last 6 months) * unable to provide consent

Keywords: virtual exercise intervention strength training older adult prediabetes muscle strength small group training
the platinum study comparison group

Conditions: Testicular Neoplasms

Summary: the patients enrolled on this new study will serve as an appropriate comparison group consisting of patients with the diagnosis of germ cell testicular cancer who were cured with surgical resection and did not receive cisplatin-based chemotherapy with a group of patients from another study who did receive cisplatin-based chemotherapy.

primary objective to compare the prevalence of ototoxicity and neurotoxicity in gct cancer survivors who only had surgery to a similar population from the platinum study (rsrb45410/1305011509) who received cisplatin-based combination chemotherapy. secondary objective to compare the prevalence of obesity, hypertension, and use of antidepressants/anxiolytics in gct cancer survivors who only had surgery to a similar population from the platinum study who received cisplatin-based combination chemotherapy.

Eligibility criteria:
inclusion criteria: * diagnosis or confirmation of diagnosis of a histologically or serologically confirmed testicular germ cell tumor (gct) or gct at another anatomic location * age at gct diagnosis: 55 years of age or younger * males, 18 years of age or older at time of study consent * subject is able to provide consent * subject is able to speak and read english * treatment consisted of surgery only (i.e., orchiectomy and/or retroperitoneal lymph node dissection \[rplnd\]) for either initial testicular germ cell tumor (gct) or subsequent testicular cancer * subject completed surgery \> 1 year ago * subject is currently undergoing active follow-up at iu * subject did not require any subsequent chemotherapy, salvage chemotherapy treatment or bone marrow transplant. * subject had no prior chemotherapy of any kind exclusion criteria: * patients with prior chemotherapy (whether for gct or any other cancer)

Keywords: cisplatin-based therapy ototoxicity neurotoxicity
paclitaxel-eluting balloon angioplasty with provisional use of nitinol stent versus systematic implantation of paclitaxel-eluting stent for the treatment of femoropopliteal de novo lesions

Conditions: Peripheral Artery Disease

Summary: to determine in patients with symptomatic femoropopliteal lesions whether percutaneous revascularization with paclitaxel-eluting balloon angioplasty (peb) and provisional nitinol stent is superior with respect to the 12-month incidence of restenosis compared to treatment with systematic paclitaxel-eluting stent (pes) angioplasty


Eligibility criteria:
inclusion criteria: * intermittent claudication or critical limb ischemia * de novo stenosis ≥ 50% or occlusion of at least 40 mm in length located in femoropopliteal arteries * presence of a clear healthy segment between the lesion in superficial femoral and common femoral artery and between popliteal and tibioperoneal trunk * presence of at least 1 patent tibial vessel with distal run-off (below-the-knee artery was considered patent if free from obstructive lesions determining angiographic stenosis \>70%) exclusion criteria: * life expectancy \<1 year * contraindication for combined antiplatelet therapy or known allergy to nickel or paclitaxel * need for major amputation (ma) at the time of enrolment * failure to recanalize intended below-the-knee arteries in cli patients at risk of major amputation

Keywords: femoropopliteal lesions
development of a molecular diagnosing platform for monitoring oral hygiene in diabetic patients

Conditions: Diabetes Mellitus; Periodontal Diseases

Summary: more than ninety percent of adults in taiwan are suspected to carry periodontal disease, which causes bad breath, swollen and bleeding gums, plaque and even tooth loss. half of the patients, however, are ignorance these clinical syndromes because of no obvious pain. a lot of researches show that periodontal disease is related to diabetes mellitus. periodontal disease causes rise of blood sugar, and more than 3 times as diabetes mellitus patients as healthy people have serious periodontal disease.in this study, the investigators collect periodontal pocket and saliva samples of participants, and selecting six periodontal disease-associated bacteria strains, including porphyromonas gingivalis (pg), fusobacterium nucleatum (fn), actinobacillus actinomycetemcomitans (aa), treponema denticola (td), prevotella intermedia (pi) and tannerella forsythia (tf) as diagnostic markers. participants will get bacteriostasis mouthwash at mouth 2. the investigators will compare the differences of blood biochemistry value and oral bacteria strains after using the mouthwash.using real-time pcr and maldi biotyper, the investigators will establish the database of oral microorganisms in diabetes mellitus patients, providing periodontal disease clinical markers of high-risk groups and the basis for personal medicine of therapy in the future.


Eligibility criteria:
inclusion criteria: 1. inclusion condition of diabetes: 1. hbalc≧6.5% 2. glucose(ac)≧126 mg/dl 3. 2-h pg≧200mg/dl during an ogtt 4. in a patient with classic symptoms of hyperglycemia or hyperglycemic crisis, a random plasma glucose≧200mg/dl 2. inclusion condition of periodontal disease (1) 16 natural teeths and 6 front teeth at lesat (2) periodontal pocket≧7 mm, and radiographic bone loss≧30% exclusion criteria: 1. people who have oral lesion, dental braces, denture, mouthwash allergy, or serious systemic disease 2. people who have ever eaten antibiotics and anti-inflammatory drugs over the last 6 months 3. people who have ever eaten immunosuppressive drugs, antiepileptic drugs, antihypertensive drugs, or anticoagulant 4. pregnant women or the woman who eat birth control pills
cardiovascular consequences after covid-19

Conditions: Cardiovascular Consequences After an Episode of COVID 19

Summary: the occurrence of cardiovascular complications in sars-cov-2 infections appears to be more frequent than in other viral respiratory infections, probably due to a singular pathophysiology of this coronavirus. the lack of characterization of cardiovascular damages linked to covid-19 could have medium and long-term consequences on the prognosis of patients. this problematic could lead to a second major public health problem linked to covid-19 and it is therefore crucial to keep monitoring and screening patients at risk. in this context of emerging infectious diseases, of poorly characterized cardiovascular damages during infection and of absence of data on the long-term evolution of the infection, the investigators propose to carry out a prospective and observational cohort study focused on the evaluation and the systematic cardiovascular follow up of patients who survived an episode of covid-19, regardless of their cardiovascular profiles.


Eligibility criteria:
inclusion criteria: • all adults affiliated to social security attending the post-covid follow-up consultation, having presented an episode of covid-19 diagnosed by at least one positive nasopharyngeal rt-pcr test for sars-cov-2 and considered recovered. exclusion criteria: * age \<18 years old * major under guardianship or curatorship * absence of non-opposition