Kornimate/medical-research-clean huggingface dataset:
different dialysis modalities and diet on gastrointestinal biome and azotaemic toxins

Conditions: Kidney Failure

Summary: . this is a prospective observational pilot study to analyse gastrointestinal tract bacterial populations in peritoneal dialysis and haemodialysis patients under the care of the royal free hospital with chronic kidney disease who have been established on regular haemodialysis and peritoneal dialysis treatments in a royal free hospital kidney care centre.

patients, attending for outpatient haemodialysis and peritoneal dialysis to be tested for gastrointestinal tract bacterial population by taking a single mouth swab, and a stool sample. additional blood sampling, when patients are having blood tests for routine clinical assessment.

Eligibility criteria:
inclusion criteria: * patients age 18 years and older up to 80 years * under the care of the royal free hospital with chronic kidney disease and established on regular haemodialysis or peritoneal dialysis. * able to provide written informed consent obtained exclusion criteria: * patients unable to provide written informed consent * patients not fulfilling inclusion criteria

Keywords: microbiome haemodialysis peritoneal dialysis
applying pediatric regimens to younger adult patients with acute lymphoblastic leukemia (all)

Conditions: Lymphoblastic Leukemia, Acute

Summary: the purpose of this study is to investigate the efficacy and safety for treating adult all patients with the pediatric protocol.

the prognosis for adult acute lymphoblastic leukemia (all) remains poor, which contrasts with that for pediatric all. it is regarded that the prognostic diversity is attributable to several differences between adults and children with respect to biological characteristics of leukemic cells, tolerance to anticancer drugs, treatment itself, and so on. it has been reported that adolescent all patients who were treated according to the pediatric protocol had a significantly better survival than those who were treated according to the adult protocol, indicating that the difference of treatment may be of considerable importance. to test the hypothesis, the japan adult leukemia study group (jalsg) has planned a phase 2 study to treat younger all patients who are negative for bcr-abl with the pediatric regimen which was used by the japan association of childhood leukemia study. those who are positive for bcr-abl can participate in a separate protocol. the regimen is especially characterized by dose-intensified l-asparaginase, high-dose methotrexate, and intensified maintenance therapy.

Eligibility criteria:
inclusion criteria: * previously untreated bcr-abl-negative all * age between 15 and 24 years * performance status between 0 and 3 (ecog criteria) * adequate functioning of the liver (serum bilirubin level \< 2.0 mg/dl); kidneys (serum creatinine level \< 2.0 mg/dl); and heart (left ventricular ejection fraction greater than 50% and no severe abnormalities detected on electrocardiograms and echocardiographs). * written informed consent to participate in the trial exclusion criteria: * uncontrolled active infection * another severe and/or life-threatening disease * positive for hiv antibody and/or hepatitis b surface (hbs) antigen tests * another primary malignancy which is clinically active and/or requires medical interventions * pregnant and/or lactating women * past history of renal failure

Keywords: acute lymphoblastic leukemia newly diagnosed bcr-abl-negative
analysis of sex hormones and lipoproteins in young males

Conditions: Cardiovascular Diseases; Atherosclerosis; Heart Diseases

Summary: to analyze the relationship of sex hormones to lipoproteins in young males.

background: the investigators conducted a secondary analysis of the sex hormones and lipoproteins in adolescent males study (hd/hl18281), a 3-year (1984-1987) study of lipids, blood pressure, weight, fat patterning, and sex steroid hormones (ssh) in adolescent males. a total of 664 black and white males, ages 10-15, were enrolled into a study designed as a series of repeated data collections over two years within age cohorts. cross-sectional analyses were used to explain differences during adolescence in sex steroid hormones and sex steroid hormone-lipid relationships between black and white boys and between boys with and without a family history of coronary heart disease.. when the data were originally collected for this study, theoretical models of flexible longitudinal analytic techniques had been developed, but were not available for computer use. these techniques, now supported by software, allow a more powerful and complete analysis of these data. design narrative: the primary aim of these analyses was to explain the contribution of changes in sex steroid hormones and fat patterning to changes in plasma concentrations of high (hdl-c) and low (ldl-c) density lipoprotein cholesterol, triglycerides (tg), and apolipoproteins (apo) al, all, and b occurring during puberty in males. sex steroid hormones assayed included estradiol (e2) and free testosterone (t). the following hypotheses were tested: (1) increasing free t predicts/leads to decreases in hdl-c and increases in ldl-c, apo b, and the ldl-c/hdl-c ratio in adolescent males; (2) increasing e2 predicts decreases in apo b, ldl-c and the ldl-c/hdl- c ratio, but the resultant effects will vary with adiposity and fat patterning; (3) rapid weight gain predicts increased central adiposity, defined as the ratio of truncal skinfolds to total skinfolds, and with greater decreases in hdl-c and increases in triglycerides, apo b, ldl-c and the ldl- c/hdl-c ratio. rapid weight gain predicts increased e2, but the atherogenic effects of increased central adiposity on lipids are greater than the anti- atherogenic effects of e2. these analyses provided a better understanding of metabolic factors underlying obesity-hormone-lipoprotein relationships. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
study to evaluate the safety and efficacy of formoterol in a daily dose of 18 µg (9 µg twice daily) in japanese chronic obstructive pulmonary disease (copd) patients

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study is a multicentre, open, randomised, parallel-group study with formoterol 9 μg one inhalation b.i.d, or standard copd therapy. standard (reference) copd treatment arm should be the group to refer to when safety results of formoterol arm will be evaluated. 240 patients with moderate-to-severe copd will be randomised (120 patients in the formoterol-arm and 120 patients on standard copd therapy).


Eligibility criteria:
inclusion criteria: * outpatients, men or women ≥ 40 years * a clinical diagnosis of copd according to guidelines, and current copd symptoms. * post-bronchodilator fev1 \< 80% of predicted normal value and fev1/fvc \< 70%, post-bronchodilator exclusion criteria: * a history and/or current clinical diagnosis of asthma and atopic diseases such as allergic rhinitis * patients who have experienced copd exacerbation requiring at least one of the following treatment, hospitalisation and/or a course of systemic steroid within 4 weeks prior to the study start. * significant or unstable ischaemic heart disease, arrhythmia, cardiomyopathy, heart failure, uncontrolled hypertension as defined by the investigator, or any other relevant cardiovascular disorder as judged by the investigator

Keywords: chronic obstructive pulmonary disease copd japanese phase 3 safety ot oxis
nasal endoscopic screening and risk assessment for early gastric cancer

Conditions: Gastric Cancer; Precancerous Lesion; Helicobacter Pylori Infection

Summary: pepsinogens (pgs) can be used for gastric cancer (gc) screening, but the cutoff levels vary among studies, and pg levels are influenced by numerous factors. to examine the diagnostic value of pg levels and helicobacter pylori (hp) status for gc and precancerous lesions screening in asymptomatic individuals undergoing health checkup in china.

pepsinogens (pgs) can be used for gastric cancer (gc) screening, but the cutoff levels vary among studies, and pg levels are influenced by numerous factors. to examine the diagnostic value of pg levels and helicobacter pylori (hp) status for gc and precancerous lesions screening in asymptomatic individuals undergoing health checkup in china. we operated a multicenter cross-sectional study of subjects who underwent health checkup at nine international healthcare centers in china. all participants underwent gastroscopy and pathological examination, serum pg, 13c-urea breath test, and/or hp serological current infection marker rapid test, all on the same day. pg related parameters were analyzed in different hp subgroups and regions.

Eligibility criteria:
inclusion criteria: intention to undergo gastroscopy during health checkup examination 25-75 years of age. exclusion criteria: a history of gastric ulcer, gastric polyp, or gc a history of gastrectomy treatment with a proton pump inhibitor in the last month contraindications to gastroscopy a history of hp eradication a history of abdominal pain, abdominal distention, belching, acid reflux, nausea and other digestive tract symptoms within 1 month incomplete data.
complex chronic diseases program data registry

Conditions: Fibromyalgia; Chronic Fatigue Syndrome; Myalgic Encephalomyelitis; Chronic Lyme-Like Syndrome

Summary: the purpose of this data registry is to prospectively collect data from patients referred to an complex chronic diseases program (ccdp) at bc women's hospital + health centre to assess the quality of life of the ccdp patients before, during and after their care at the ccdp.

1. before their initial intake appointment, all ccdp patients are given a patient binder that includes the baseline standardized questionnaires. these are clinical questionnaires that all patients complete regardless of whether or not they consent to participation in research. in addition to the questionnaires completed at baseline, patients who consent to participate in the data registry will complete the questionnaires, via email or paper copy, at the following time points: approximately 6 months after intake, at discharge and 3 months post-discharge. 2. patients who consent to the data registry will also be asked to complete a short questionnaire collecting basic demographic information at baseline. the demographic questionnaire will be either mailed to their home or sent via an online link; the investigators will ask participants to complete this form either before or when they come in for their first in-person visit at the ccdp. 3. additional data will be collected and entered from the clinical chart. specifically, after the patient's initial clinic appointment, the research coordinator or designate will enter data points from the interdisciplinary assessment tool, into redcap.

Eligibility criteria:
inclusion criteria: * newly referred patients of the complex chronic diseases program * must be able to read and understand english * 18 years of age or older exclusion criteria: * have not completed the standardized questionnaires booklet prior to the initial intake assessment.

Keywords: fatigue pain chronic pain data registry me/cfs cfs fm post-exertional malaise lyme
dose response of exercise for arthritis management

Conditions: Arthritis; Rheumatoid Arthritis (RA); Gout; Fibromyalgia (FM); Osteoarthritis; Lupus Erythematosus, Systemic

Summary: the purpose of the study is to see examine the effects of 3 different levels of physical activity (45 minutes/week, 90 minutes/week, or 150 minutes/week) on arthritis symptoms.

all participants will be randomly assigned a physical activity goal (45 min/week, 90 min/week, or 150 min/week). to help participants achieve goals, they will receive a 6 month program which includes the arthritis foundation's walk with ease guidebook, behavioral lessons, a fitbit, and monthly coaching calls. participants may also receive additional calls, texts, or emails if they are struggling to meet their physical activity goals.

Eligibility criteria:
inclusion criteria: * 18 years or older * have a doctor diagnosed form of arthritis, rheumatoid arthritis, gout, lupus, or fibromyalgia * ability to read and write in english exclusion criteria: * have any contraindications to exercise (besides arthritis) * engage in ≥30 min/week of actigraph assessed mvpa * are pregnant, breastfeeding, or planning to become pregnant in the next year * are planning to relocate out of the columbia, sc area in the next 12 months, * do not have a device compatible with fitbit * have uncontrolled hypertension (e.g., systolic blood pressure \> 160 mmhg or diastolic blood pressure \> 100 mmhg) * plan to have a surgery that affects mobility in the next 12 months * have a serious cognitive impairment. * not willing to be randomized to any of the 3 conditions, do not believe they could adhere to the goals, or do not believe they could achieve the highest dose of activity (150 minutes/week).

Keywords: arthritis exercise physical activity
patient reported unmet needs for function and supportive occupational- and physiotherapy rehabilitation interventions

Conditions: Cancer; Kidney Diseases; Heart Failure; Neurologic Disorder; Liver Diseases; Pulmonary Disease; Side Effect; Quality of Life; Physical Disorder

Summary: purpose: to determine unmet functional needs in patients referred to the palliative care unit at rigshospitalet, copenhagen university hospital will be asked to fill out self reported questionnaires regarding problem intensity, problem burden and felt needs, physical functioning, emotional functioning, fatigue, sleep, distress. furthermore patients physical function will be evaluated.

physical functioning is found to be an important predictor for survival and physical ability 'to do what one wants' affects quality of life in cancer patients in palliative care and their spouses. despite this, physical functioning is reported as a neglected dimension in palliative care quality of life outcome measures, and advanced cancer patients report that they do not receive the help they need. the vast majority of patients with advanced cancer described unmet palliative care needs, and with the most frequently reported problems being; fatigue (73%), limitations doing physical activities (65%), limitations in work and daily activities (58%), worry (58%), difficulties with sexuality (54%), pain (52%) and problems with concentration (43%). furthermore, limitations in physical functioning and physical activity is a leading cause of distress and psychological problems a rehabilitative approach in palliative care integrated in the interdisciplinary interventions to the patients must be maintained throughout the entire illness trajectory from diagnosis through treatment, rehabilitation and palliative care to address such problems. however, prevalence of patient unmet needs and reported physical functioning and performance is reported to differentiate largely between palliative units. in order to address the functional needs of patients receiving specialist palliative care studies of their specific needs are required. therefore, the aim of this study is to investigate the patient reported unmet needs for function and supportive occupational- and physiotherapy rehabilitation interventions in the palliative unit at copenhagen university hospital, rigshospitalet. furthermore, we aim to investigate if observations, additional disease-specific patient reported outcomes and assessment of physical function and performance can support the unmet needs.

Eligibility criteria:
inclusion criteria : all adult patients (≥ 18 years) referred to the palliative care unit at copenhagen university hospital, rigshospitalet. exclusion criteria: inability to read and understand danish

Keywords: palliative care physical functioning unmet needs
effects of an amino acid mixture on gastrointestinal function, inflammation and fluid balance: a pilot study in patients with inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases; Short Bowel Syndrome; Ileostomy - Stoma

Summary: this pilot study will examine the benefit of this amino acid based hydration solution in patients with ibd who have undergone a total colectomy and have either ileostomies or jpouches. findings from this study and possible future studies could have broad implications for patients with malabsorption resulting from many underlying conditions, including ibd.

this pilot study will examine the benefit of this amino acid based hydration solution in patients with ibd who have undergone a total colectomy and have either ileostomies or jpouches. findings from this study and possible future studies could have broad implications for patients with malabsorption resulting from many underlying conditions, including ibd.

Eligibility criteria:
inclusion criteria: 1. colectomy with ileostomy a. ileostomy alone with less than 30 cm of small bowel resected i. a diverting ileostomy is permitted 2. stable disease activity with no or mild inflammation felt not to significantly impact gastrointestinal (gi) output. 3. any of the following: 1. need for iv fluids \>2x/month 2. intake of \> 1.5 liters of oral fluid daily 4. gi output of \> 1.3 liters in a 24-hour period for three days each week during a 14 day screening period (does not need to be consecutive days) 5. stable doses of anti-diarrheal agents, octreotide or gattex 6. stable doses of anti-inflammatory agents and/or antibiotics 7. willing to comply with study visits and assessments, including product intake. exclusion: 1. chronic renal insufficiency glomerular filtration rate (gfr) \< 40 2. significant chronic liver disease altering fluid balance 3. uncontrolled flare of inflammatory disease a. (inflammation can be present but at a stable at least partly controlled level) b. an anticipated change in medication in the next 3 months i. may be included 8 weeks after changing medications if they are stable c. anticipated gastrointestinal surgery in the subsequent 3 months i. may be included if they are 4 months out from surgery and stable 4. diabetes 5. use of lactulose/mannitol solution is contraindicated 6. current diagnosis of cancer a. may be included if they are 4 or more months out from cancer therapy (i.e. chemotherapy, etc.) 7. aversion to the taste of enterade® or inability to take the product as instructed
substance consumption, personality, and cognitive functioning of chess players

Conditions: Addiction; Alcohol; Nicotine; Drugs; Personality; Depression; Anxiety

Summary: the aim of this project is to find out if there is a difference in addictive behavior, personality traits, and cognitive abilities between chess players and non-chess players.

in the present planned study, tournament chess players will be compared with non-tournament chess playing individuals by means of an online survey. among other things, the investigators want to investigate whether these groups of persons differ in various characteristics such as their consumption behavior (alcohol, tobacco, and drug use), their personality, their depressiveness and mood, or their cognitive abilities. the background is the question whether playing chess could be protective against substance use disorders or could mitigate the manifestation.

Eligibility criteria:
inclusion criteria: * all persons from the age of 18 years * inclusion in the group of chess players is based on the existence of a dwz. * sufficient ability to answer the questionnaires exclusion criteria: * none
changing health through food support (chefs) program

Conditions: HIV/AIDS

Summary: ucsf and project open hand (poh), a community based organization in san francisco which provides meals and groceries to chronically ill clients in the bay area, have partnered to conduct an initial randomized controlled trial (rct) of the changing health through food support (chefs) pilot intervention implemented by poh. the intervention consists of providing comprehensive, medically-appropriate food support, individual nutritional counseling, and group-based nutritional education over 6 months to low-income clients who have been diagnosed with hiv in order to improve their viral load and health-related quality of life (primary outcomes) as well as depression, art adherence, food security and diet quality (secondary outcomes). we will randomize 200 participants to the intervention (n=100) or control (n=100). participants will be followed for 6 months. the investigators will assess outcomes at baseline and 6-month follow-up using a quantitative survey and blood draws. in addition, the investigators will conduct a qualitative study at follow-up in a subset of participants to understand perceived impacts, barriers and facilitators.


Eligibility criteria:
inclusion criteria: * hiv positive * income at or below 200% fpl (\~$2400/month) * 30-50% minimum poh regular program adherence level (i.e. regular service access rate) * are willing and able to eat food from poh based on one of poh's regularly available diet choices (including regular, non-dairy, vegetarian, vegetarian non-dairy, diabetic, and bland), excluding the renal diet. * have access to a refrigerator or freezer with sufficient space to store perishable food provided by poh, and have access to an appliance to reheat food. exclusion criteria: * do not speak spanish or english * do not have adequate cognitive or hearing capacity to complete interviews * have a history of violent behavior at poh (such as verbal or physical abuse to other clients and/or staff) * have renal disease requiring a special renal diet * have severe food allergies * currently pregnant or \<6 months post-partum * unable to complete an interview due to a health condition * unable or unwilling to eat food from poh (based on one of poh's regularly available diet choices) * among people who share a household (such as partners, family members, or roommates), only one may be involved in the study.

Keywords: food insecurity community-based food assistance food support intervention medically tailored nutrition
effect of non-invasive vagus nerve stimulation on cognitive functions in diabetic polyneuropathy patients

Conditions: Diabetic Peripheral Neuropathy

Summary: diabetic peripheral neuropathy (dpn) occurs due to long standing hyperglycemia and associated metabolic derangements. cognitive impairment is a common complication in diabetes mellitus. it is associated with a faster rate of cognitive decline.

this research aims to * determine the effect of non-invasive vagus nerve stimulation on cognitive functions in diabetic peripheral neuropathy. * investigate the correlation between cognitive function and severity of diabetic neuropathy. * investigate the correlation between cognitive function and quality of life in diabetic peripheral neuropathy.

Eligibility criteria:
inclusion criteria: * patients with diabetic polyneuropathy * female patients. * age ranges from 40 to 55 years old. * duration of diabetic illness started since at least three years. * patients with mild to moderate neuropathy according to toronto clinical neuropathy score * patients with cognitive function ranges from 24 - 15 score according to mini mental state examination * patients with hba1c ranges from seven to nine score. * ambulant patients with or without walking aids. * medically and psychologically stable patients without cardiac problems, confirmed by electro cardiogram (ecg). * able to understand instructions. exclusion criteria: * type i diabetes mellitus. * severe visual, verbal or acoustic impairments. * sever cognitive dysfunctions or that caused by other cause rather than diabetes mellitus. * polyneuropathy caused by other cause rather than diabetes mellitus. * other neurological problem as stroke. * cardiovascular problems. * metallic implants * illiterate patients. * uncooperative patients.

Keywords: vagus nerve stimulation cognitive functions