Kornimate/medical-research-clean huggingface dataset:
application of as101 for the treatment of thrombocytopenia in solid tumor patients

Conditions: Chemotherapy Induced Thrombocytopenia

Summary: chemotherapy induced thrombocytopenia is a common side-effect of bone marrow suppression as a result of a chemotherapy treatment. as101 is a tellurium based small compound with immunomodulating characteristics which attributed to the direct inhibition of the anti-inflammatory cytokine il-10. as101 was previously shown to induce a significant reduction in thrombocytopenia that accompany cancer therapy with no major toxicity . this phase ii randomized open study will evaluate the efficacy of as101 for the treatment of chemotherapy induced thrombocytopenia in patients with various solid tumors.


Eligibility criteria:
inclusion criteria: * age ≥ 18 * appropriate histology of solid tumors. * platelet counts \< 70,000/μl. * performance status (ps) of 0-2 * adequate renal function: serum creatinine ≤1.5 mg/dl * adequate liver function: serum (total) bilirubin ≤ 1.5 uln. ast, alt ≤ 2.5 x uln in patients without liver metastases, ≤ 5 x uln in patients with liver metastases. albumin ≥ 2.5 g/dl (only for patients who will receive as101). * inr ≤ 1.5 and ptt ≤ 1.5 x uln (only for patients who will receive as101). exclusion criteria: * patients unable to provide fully informed consent. * women who are pregnant or breast feeding. * the patient is participating in another trial of an investigational drug or has done so within 28 days prior to the pre-treatment visit. * the patient has congestive heart failure-new york heart association (chf-nyha) grade ii or higher, and/or myocardial infarction within the last 12 months, or any cardiac disorder which in the opinion of the investigator would put the patient at risk. * the patient has a history of chronic alcohol or drug abuse within the last 5 years. * the patient has any other clinically significant medical condition, psychiatric condition or laboratory abnormality which would, in the judgment of the investigator, interfere with the patient's ability to participate in the trial.
multi-joint muscle fatigability and gait performance in people with multiple sclerosis

Conditions: Multiple Sclerosis; Gait Disorders, Neurologic; Fatigue

Summary: the purpose of this study is to compare walking to leg strength and endurance in people with multiple sclerosis (pwms). using these findings, we hope to be better understand what causes pwms to have problems walking.

the purposes of the research are to determine the association of gait performance with lower extremity muscle fatigability and strength measures, and create a preliminary model that can better explain the variance in gait performance based on these muscle performance values. objective criterion-based measures of physical fatigue (i.e., fatigability) and muscle weakness have been associated with impaired task performance in people with multiple sclerosis (ms). ms-related deficits in muscle capacity result in higher fall risks and a loss of function. however, it is unclear if lower extremity fatigability tests add clinical value to objective strength testing in the rehabilitation and clinical management of ms. better understanding how patterns of lower extremity (le) fatigability and strength affect mobility in people with ms could improve outcome measure development and inform rehabilitation strategies.

Eligibility criteria:
inclusion criteria: * age 18-85 years * history of multiple sclerosis * expanded disability status scale \< 7.0 * receives care at the washington dc veteran's affairs medical center neurology service and multiple sclerosis center of excellence - east
assessing the use of my-ride, a just-in-time adaptive intervention, to improve hiv prevention and substance use in youth experiencing homelessness

Conditions: HIV Infections

Summary: the purpose of this study is to determine whether motivating youth to reduce infections, disconnections, and emotion dysregulation (my-ride) decreases substance use , to determine whether my-ride increases human immunodeficiency virus (hiv) prevention strategies and to evaluate my-ride effects on willingness to take pre-exposure prophylaxis (prep), stress, substance use urge, and use of mental health and substance use services when compared to attention control youth


Eligibility criteria:
inclusion criteria: * have engaged in substance use (alcohol or illicit drugs) * speak english * are experiencing homelessness * engaged in sexual activity in the last 6 months or plan to in the next month * are not planning to move out of the metro area during the 15-month study period. exclusion criteria: * youth experiencing homelessness (yeh) who have low literacy based on the rapid estimate of adult literacy in medicine-short form (scores \< 4)
eosinophilic gastrointestinal disorders patient registry

Conditions: Eosinophilic Esophagitis; Eosinophilic Gastritis; Eosinophilic Enteritis; Eosinophilic Colitis

Summary: the eosinophilic gastrointestinal disorders (egids) registry is a longitudinal study that does not involve medical interventions, but serves as a record of demographics, characteristics of disease and treatment, utilization patterns, quality improvement measures and clinical outcomes. the database is proposed so that epidemiologic research can be performed and current and accurate data can be obtained regarding practice patterns, age and gender distributions, efficacy of treatment, clinical outcomes and changes in quality of life.


Eligibility criteria:
inclusion criteria: * male or female participants of any race or ethnicity * age 0 to 21 years * diagnosis of egid including: eosinophilic esophagitis, eosinophilic gastritis, eosinophilic enteritis, eosinophilic colitis exclusion criteria: * hypereosinophilic syndrome * non-eosinophilic gastrointestinal or allergic disorder

Keywords: eosinophilic esophagitis eosinophilic gastritis eosinophilic enteritis eosinophilic colitis
effect of bariatric surgery on cardiac function in patients with hypertension

Conditions: Bariatric Surgery; Hypertension

Summary: the purpose of this study is to investigate the effect of bariatric surgery on cardiac function assessed by echocardiography in patients with hypertension.

obesity is the most common chronic metabolic disease worldwide, causing the increasing burden of cardiovascular risk factors such as hypertension, and affecting cardiac structure and function in the long term. nowadays, bariatric surgery is regarded as the most effective approach for weight loss, and the only approach for reducing obesity-related cardiovascular events. however, the effect of different bariatric surgeries such as laparoscopic sleeve gastrectomy (lsg) or roux-en-y gastric bypass (rygb) on cardiac function in patients with hypertension is still unclear. therefore, the aim of this study was to evaluate the benefit of different bariatric surgeries on cardiac structure and function echocardiography in patients with hypertension.

Eligibility criteria:
inclusion criteria: * 18-70 years old * bmi\>24kg/m2 * bariatric surgery patients of beijing friendship hospital * history of hypertension and treated with ≥2 antihypertensive drugs for more than 4 weeks * no major barriers to provide written consent exclusion criteria: * secondary hypertension, except because of sleep apnea * cardiovascular disease (myocardial infarction, heart failure, stroke or coronary revascularization) within 6 months * severe concomitant diseases (autoimmune disease, malignancy, late stage of liver diseases, respiratory diseases and digestive diseases) * unable to understand or comply with the study procedures

Keywords: cardiac function echocardiography
the effect of caffeine on postextubation adverse respiratory events in children with obstructive sleep apnea (osa).

Conditions: Sleep Apnea, Obstructive; Tonsillectomy; Adenoidectomy; Postoperative Complications

Summary: this is a research study using caffeine in children who have an obstructive sleep apnea (osa). osa means children who stop breathing during their sleep due to obstruction in their airway. the purpose of this study is to determine whether caffeine when given in the vein, will wake children up faster and decrease post-anesthesia airway obstruction, as well as the safety and if the drug agrees with the child compared to a placebo (an inactive or dummy agent).

patients with osa are reported to have a higher rate of severe respiratory complications associated with upper airway obstruction during anesthesia and sedation or immediately after anesthesia. children with osa (especially those under three years of age, those with severe osa, cerebral palsy or craniofacial anomalies) are at increased risks for post-operative complications, and require careful monitoring post-operatively. although the etiology of obstructive sleep apnea is mainly obstruction due to anatomical and neuromuscular abnormalities, we believe that a central element may contribute to osa. the aim of this study is to evaluate whether administration of caffeine to children with osa, scheduled for elective t \& a under general anesthesia contributes to a faster recovery, less post-operative complications, and a shorter stay in the pacu, dsu and the hospital.

Eligibility criteria:
inclusion criteria: * children between 2.5-18 years old * diagnosed with obstructive sleep apnea * undergoing elective tonsillectomy and adenoidectomy exclusion criteria: * age below 2.5 or above 18 years

Keywords: obstructive sleep apnea (osa) tonsillectomy and adenoidectomy (t&a) postoperative complications recovery
a machine learning approach to connect multiple myeloma complexity to early disease recurrence

Conditions: Multiple Myeloma (MM)

Summary: this is a non-interventional, national, multicenter prospective non-profit observational study aiming at improving the accuracy of risk prediction in multiple myeloma (mm) by applying machine-learning tools for data processing to develop model(s) predicting response to therapy and the probability of early relapse for mm patients.

improvements in the therapy of mm have prompted the achievement of very deep clinical responses, with significantly improved outcomes and survival \[2\]. however, despite significant therapeutic progress, mm remains a challenge, due to the composite pathogenesis and intricate networks of different interacting factors. as a result, a relatively high proportion of ndmm patients across the different therapeutic strategies have a higher risk of disease progression and worse outcomes, independently of the anti-mm regimen received. these patients currently represent un unmet clinical need, with consequent challenges in the management of the disease and identify these patients upfront is an important goal in mm. at present, risk stratification scores rely on a limited set of clinical and biological variables, not always sufficient to identify patients at a high risk of early disease progression or relapse (i.e., within 12 months from start of first-line therapy). recently, ai tools have been explored to improve the accuracy of risk prediction, showing that high-risk diseases might be upfront recognized, based on tumor and immune biomarkers \[3-4\]. by applying machine learning (ml) tools for data processing, clinical, genomic, and imaging data from mm patients will be integrated and employed in models aimed at improving the accuracy of mm risk prediction. in this way, ml models will aggregate all tumor- and microenvironment-related information obtained by high-throughput technologies and omics approaches to identify and describe clusters of mm patients that best correlate with the achievement of early progression. overall, this study will identify new knowledge to support clinical research and decision-making in mm: precise up-front stratification of patients, based on the whole landscape of mm-related features, could improve understanding of mm individual risk. results from this study will have an impact on the possibility to access personalized treatment, with predictable overall repercussion on the effective management of mm patients and savings for the national health system.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * signed informed consent form for study participation and personal data processing * diagnosis of active multiple myeloma exclusion criteria: * none
comparison of the effectiveness of emg-biofeedback and rebound therapy in patients with endometriosis

Conditions: Endometriosis

Summary: the aim of our study is to investigate the effects of pelvic floor muscle strengthening exercises with emg-biofeedback and pelvic floor muscle strengthening exercises with rebound therapy on pelvic floor muscle strength, pain level, ngf level, perceived stress level, quality of life and sleep in women diagnosed with endometriosis.

endometriosis is a chronic, systematic, inflammatory, estrogen-dependent public health problem characterized by the growth of endometrial-like tissue outside the uterine cavity, including the pelvic peritoneum, rectovaginal septum and ovaries, and is particularly seen in women of reproductive age and significantly affects quality of life. the aim of our study is to investigate the effects of pelvic floor muscle strengthening exercises with emg-biofeedback and pelvic floor muscle strengthening exercises with rebound therapy on pelvic floor muscle strength, pain level, ngf level, perceived stress level, quality of life and sleep in women diagnosed with endometriosis. the study will consist of 3 groups. group 1: emg-biofeedback group, group 2: rebound therapy group and group 3: home exercises group. participants will be included in the study for 8 weeks. during the evaluation, pelvic floor muscle strength will be assessed with emg, pain level with visual analog scale (vas), perceived stress level with perceived stress scale, quality of life with endometriosis health profile questionnaire (ehp-30), and sleep quality with pittsburgh sleep quality index (psqi). ngf analysis will be evaluated by analyzing serum samples of patients with elisa kit. evaluations will be made before and after treatment.

Eligibility criteria:
inclusion criteria: * being between 20-50 years old, * being diagnosed with endometriosis, * completing the voluntary consent form, * pain level being at least 4 on the visual analog scale (vas). exclusion criteria: exclusion criteria for the emg-biofeedback group: * being included in another study during the study period, * being receiving medical treatment for endometriosis, * presence of gynecological bleeding, * presence of communication and cooperation problems, * presence of tubo-ovarian abscess, * active vaginal or urinary tract infection, * pregnancy and giving birth within the last 12 months, * presence of impaired somatosensory status, * not attending 2 consecutive sessions. exclusion criteria for the rebound therapy group: in addition to the exclusion criteria determined for the emg-biofeedback group; * presence of a neurological or orthopedic disease affecting the lower extremity, * history of spine and/or lower extremity orthopedic surgery, * presence of severe arthritis affecting the spine and/or lower extremity, * presence of uncontrolled hypertension and cardiovascular disease.

Keywords: endometriosis pain quality of life sleep quality
stress urinary incontinence in women with multiple sclerosis

Conditions: Urinary Incontinence, Stress; Multiple Sclerosis

Summary: objective: to report the prevalence and risk factors of stress urinary incontinence (sui) and the prevalence of intrinsic sphincter deficiency in women with multiple sclerosis (ms). methods: a retrospective study was conducted among female patients with ms, followed for lower urinary tract symptoms (luts) during a 15-year period. demographic data, ms history, expanded disability status scale (edss) score at the urodynamic visit, obstetrical past, birth weight, luts, and urodynamic findings were collected. sui was defined as incontinence during cough, or any effort. a maximum urethral closure pressure less than 30 cm h2o defined intrinsic sphincter deficiency. results: in total 363 women with a mean age of 46.7±10.8 years and a mean disease duration of 12.9±8.7 years were included. the incidence of relapsing remitting ms, a secondary progressive form, and a primary progressive form was 60.6%, 32.8%, and 6.6%, respectively. the prevalence of sui was 31.4%. the prevalence of intrinsic sphincter deficiency was 1.4% and 0.8% of these patients had a sui (p=0.300). in a multivariate analysis, women with a sui had significantly higher birth weight (p=0.030), a pelvic organ prolapse (p=0.021), urgent urinary incontinence (p=0.006), a lower edss score (p=0.019), and a weaker containing effort (p\<0.001). conclusions: the prevalence of sui in women with ms was 31.4%. this symptom could affect the quality of life of women with ms.


Eligibility criteria:
inclusion criteria: * women aged \>18 years * multiple sclerosis * urodynamic test for lower urinary tract symptoms * followed in saint philibert hospital between december 1999 to june 2014 exclusion criteria: * non confirmation of diagnosis of multiple sclerosis

Keywords: urinary incontinence, stress multiple sclerosis lower urinary tract symptoms
risk factors for ectopic pregnancy: comparison of fresh and warmed transfers. analysis of a 10 years, a single center experience.

Conditions: Ectopic Pregnancy; Assisted Reproductive Technology

Summary: ectopic pregnancy (ep) is a leading cause of maternal death during the first trimester of pregnancy. previous studies have reported an increased incidence of ep in assisted reproductive technologies techniques (art) (clayton et al., 2006), and in particular with fresh blastocyst embryo transfer compared with warmed embryo transfer (londra et al., 2015). in consideration of the widespread use of art techniques in gynaecology and the high morbidity and mortality associated with ep, providing further insight into the risk factors associated with eps in art appears of great relevance. the objective of this study is to compare the incidences of eps in all art procedures (both i and ii level) in a single, third level art center throughout a 10-year period. in addition, we also aim to revise recognized ep's risk factors among patients undergoing these procedure and to evaluate their impact in determining extrauterine implantation

ectopic pregnancy (ep) remain a leading cause of maternal death during the first trimester of pregnancy. previous studies have reported an increased incidence of ep in assisted reproductive technologies techniques (art) (clayton et al., 2006), and in particular with fresh blastocyst embryo transfer compared with warmed embryo transfer (londra et al., 2015). however a metanalysis on the topic argued that the results of many studies vary significantly within years of publishing and center locations; therefore, an accurate management strategy for patients at risk of ectopic gestation after invitro fertilization and embryo transfer (ivf-et) procedure has not been established(v. muller et al., 2016). in addition literature on i level art procedures appears to be lacking. in consideration of the widespread use of art techniques in gynaecology and the high morbidity and mortality associated with ep, providing further insight into the risk factors associated with eps in art appears of great relevance. indeed, revising ep risk factors may help in reducing ep incidence in art through the stratification of women according to their characteristics and the employment of special measures. the objective of this study is to compare the incidences of eps in all art procedures (both i and ii level) in a single, third level art center throughout a 10-year period. in addition, we also aim to revise recognized ep's risk factors among patients undergoing these procedure and to evaluate their impact in determining extrauterine implantation.

Eligibility criteria:
inclusion criteria: * women with diagnosis of ep. ectopic pregnancy diagnosis was performed with b-hcg measurement and imaging visualization of the gestational sac outside the uterus exclusion criteria: * no case was excluded
new moms mood tracking & wellbeing

Conditions: Depression; Perinatal Depression; Anxiety; Pregnancy Related

Summary: new moms can be at risk for perinatal depression (pnd). the new moms mood tracking and wellbeing study is investigating mood changes, risk factors for depression and anxiety and treatment response around the time of delivery. participants will be asked to complete three sets of online surveys between week 28 gestation and week 20 after delivery, in addition to downloading an app to collect data using their smartphone sensors and brief symptom surveys every other week. women with elevated symptoms will be eligible to participate in a treatment study. women who are eligible for the treatment study will be randomized to one of two conditions - perinatal psychiatric care or screening and treatment for anxiety and depression (stand). in perinatal psychiatric care, participants will receive appointments with psychiatry clinicians for medication management and supportive therapy. in stand, participants will be allocated to online therapy with coaching or clinical care, which includes both psychotherapy and psychiatry appointments. treatment can last up to 6 months and there will be treatment related assessments for the duration of the 6 months, in addition to brief symptom surveys on a regular basis. therefore, participation can last between 24 and 52 weeks, as both time of delivery and treatment enrollment timepoint cannot be scheduled in advance.


Eligibility criteria:
inclusion criteria: * women who are between week 28 of their pregnancy and 6 months postpartum and are receiving care at a ucla ob-gyn clinic * fluent in english * current endorsement of moderate or higher depression on the edinburgh postnatal depression scale (epds, =\> 11 sum score), administered by the treating ob-gyn physician or study staff * not currently in individual treatment for a behavioral or emotional problem (e.g., anxiety, depression) * willingness to follow study procedures * willingness to participate in treatment through the study and follow all study procedures, including provide hipaa authorization for research * has access to the internet via mobile or desktop device exclusion criteria: * are currently receiving treatment by a therapist or a psychiatrist * unstable suicidality (e.g., 2 or more suicide attempts or self-injurious behaviors resulting in hospitalization in the last 6 months, combined with high ratings on self-reported negative urgency) * current substance use disorder that interferes with treatment: specifically, patients meeting diagnostic criteria for substance use disorder (sud) will be eligible for inclusion only if they are able to attend sessions while not under the influence of that substance, with the exception of individuals abusing opiates or freebase cocaine, who will be excluded * principal diagnosis of psychosis unrelated to depression (unipolar or bipolar) * neurological conditions * severe uncontrolled medical conditions (e.g., anorexia nervosa, cardiac conditions requiring continuous monitoring) * cognitive impairment (e.g., developmental disability, dementia)