Kornimate/medical-research-clean huggingface dataset:
effect and safety of the dietary supplement mannite in pediatric patients with chronic functional constipation

Conditions: Constipation - Functional

Summary: functional constipation is a widely prevalent pediatric issue, with a prevalence in some studies as high as 32.2%. treatment consists of a combination of behavioral and pharmacological interventions (mainly, administration of polyethylene glycol laxatives or the use of enemas). glucomannan (gnn) is a polysaccharide of 1,4-d-glucose and d-mannose found in the soluble fiber of some plants. while studies available in the literature to date agree that mannite is a dietary supplement with safe use, the usefulness of this compound remains controversial.

functional constipation is a widely prevalent pediatric issue, with a prevalence in some studies as high as 32.2%. characterized by annoying and embarrassing symptoms such as reduced number of evacuations, increased stool consistency, fecal incontinence, and abdominal pain functional constipation has a negative impact on the quality of life of affected children and their families. it is a frequent reason for referral to the general pediatrician and pediatric gastroenterologist and significantly impacts health care spending the guidelines publicized by the european society for pediatric gastroenterology, hepatology and nutrition (espghan) and the north american society for pediatric gastroenterology, hepatology and nutrition (naspghan) on functional constipation in children provide the most up-to-date evidence-based recommendations for the evaluation, treatment and follow-up of children with this condition. key indications include a diagnosis based on history and physical examination and a definition of functional constipation based on the criteria of rome. treatment consists of a combination of behavioral and pharmacological interventions (mainly, administration of polyethylene glycol laxatives or the use of enemas). glucomannan (gnn) is a polysaccharide of 1,4-d-glucose and d-mannose found in the soluble fiber of some plants. while studies available in the literature to date agree that mannite is a dietary supplement with safe use, the usefulness of this compound remains controversial. the study aims to evaluate the effect of mannite supplement (composed of 90% mannite from fructose and 10% manna from ash) as a unique therapy in the treatment of functional constipation.

Eligibility criteria:
inclusion criteria: * diagnosis of functional constipation defined according to rome iv criteria. * age between 6 months and 16 years. * informed consent signed by parent/legal guardian exclusion criteria: * presence of organic causes of bowel disorders (hirschsprung's disease, spinal abnormalities or anorectal pathology; history of gastro-intestinal surgery), celiac disease * mental retardation * irritable bowel syndrome * taking medications that affect gastro-intestinal motility in the previous 4 weeks * clinical suggestive of metabolic disease (e.g., hypothyroidism) * known hypersensitivity to manna, mannitol, or other ingredient in the dietary supplement mannite

Keywords: constipation
intravitreal mtx and zr regimen in newly diagnosed pvrl

Conditions: Primary Vitreoretinal Lymphoma

Summary: this is a prospective single-arm phase ii study, and the purpose of this study is to evaluate the efficiency of zr regimen (rituximab \& zanubrutinib) combined with intravitreal methotrexate and followed by zanubrutinib maintenance in newly-diagnosed primary intraocular lymphoma. progression-free survival (pfs) of the cohort is the primary endpoint.

all the patients will be treated with zr regimen (rituximab 375mg/m2 iv d1, zanubrutinib 160mg bid, 21 days per cycle) as induction regimen, meanwhile intravitreal methotrexate was given at a dose of 400ug for 16 doses. the response will be evaluated every 3 cycles. after 3 cycles, patients who achieved complete remission (cr) or partial remission (pr) will receive 3 more cycles of zr regimen. the patients with stable disease (sd) or progressed disease (pd) will withdraw from the trial and receive salvage regimens. after total 6 induction cycles, the investigators evaluate the efficiency again, the patients with cr or pr will go to zanubrutinib maintenance for 2 years or until progression of the disease (pd), unacceptable toxicity, or patient/investigator discretion. and the patients with sd or pd will receive a salvage regimen. during following-up, surveillance ophthalmologic examination, and brain magnetic resonance imaging (mri) scans can be performed every 3 months up to the first 2 years, followed by the doctor visit every 6 months up to 5 years or the disease relapses.

Eligibility criteria:
inclusion criteria: * newly-diagnosed primary vitreoretinal lymphoma * ecog≤2 * creatinine clearance rate (ccr) ≥ 60ml/h, according to cockcroft-gault * total bilirubin # 2 upper limits of normal, alanine aminotransferase#alt# \< 3 upper limits of normal * sign the informed consent * women of childbearing potential must understand that the study medication could have a potential teratogenic risk. they should undergo complete contraception during the study period. * male subjects must agree to use condoms throughout study drug therapy. exclusion criteria: * primary central nervous system lymphoma involved eyes and brain * systemic b cell lymphoma involved eyes * pre-existing uncontrolled active infection * clinical evidence of grade 3 or 4 heart failure as defined by the new york heart association criteria * pregnancy or active lactation * co-existing tumors * hiv or hbv or hcv

Keywords: intravitreal methotrexate injection rituximab primary vitreoretinal lymphoma zanubrutinib
the double exposure study: the impact of job strain and marital cohesion on blood pressure

Conditions: Hypertension

Summary: psychosocial and lifestyle stressors, such as job strain (js) and marital factors have previously been associated with a sustained increase in blood pressure (bp). in a one-year longitudinal follow-up to the baseline double exposure cohort study, we, the researchers at sunnybrook and women's college health sciences centre, evaluated whether js and marital cohesion continued to be associated with ambulatory blood pressure (abp) in subjects enrolled with normal or untreated high bp.

psychosocial and lifestyle stressors, such as job strain (js) and marital factors have previously been associated with a sustained increase in blood pressure (bp). in a one-year longitudinal follow-up to the baseline double exposure cohort study, we evaluated whether js and marital cohesion continued to be associated with ambulatory blood pressure (abp) in subjects enrolled with normal or untreated high bp.

Eligibility criteria:
inclusion criteria: * age 40-65 * unmedicated for at least 6 months * living with spouse for at least 6 months * working for at least 6 months exclusion criteria: * working rotating or evening shifts

Keywords: hypertension; job strain; marital strain; blood pressure
the effect of community intervention on different degrees of dementia

Conditions: Alzheimer Disease

Summary: the goal of this clinical trial is to explore the impact of community intervention on dementia and activities of daily living in community-dwelling elderly individuals (≥60 year old) with alzheimer's disease. it primarily aims to address: the effects of community intervention on dementia and activities of daily living in community-dwelling elderly individuals with alzheimer's disease in different degrees. all participants are required to undergo a continuous 2-week (14 days) community intervention, with weekends off and training conducted only on weekdays. the training will be conducted two sessions per day, lasting 30 minutes each.

regular exercise can increase brain function, improve memory, speed up cognitive processes, and fight off diseases like alzheimer ' s and dementia. the goal of this clinical trial is to explore the impact of community intervention on dementia and activities of daily living in community-dwelling elderly individuals (≥60 year old) with alzheimer's disease. it primarily aims to address: the effects of community intervention on dementia and activities of daily living in community-dwelling elderly individuals with alzheimer's disease in different degrees. all participants are required to undergo a continuous 2-week (14 days) community intervention, with weekends off and training conducted only on weekdays. the training will be conducted two sessions per day, lasting 30 minutes each.

Eligibility criteria:
inclusion criteria: * age over 60 years old. * no hospitalization within the past six months. * alzheimer's disease * the elderly people who voluntarily participate and agree to adhere until the end of the study. exclusion criteria: * complicated with severe liver and kidney failure, tumors, or hematological disorders. * physical disability. * difficulty in mobility. * simultaneously receiving other therapies that might influence this study.
black garlic nutraceuticals and blood pressure control

Conditions: Hypertension

Summary: black garlic contains a series of allyl-sulfur compounds with the ability to modulate nitric oxide synthetase, angiotensin-converting enzyme system, and endothelial activation, which together could help better control blood pressure. the main objective of this study is to evaluate the effect on blood pressure and endothelial health of a daily intake of a black garlic supplement named abg (registered mark), which has a higher concentration of black garlic bioactive compounds, in people with moderate hypertension.


Eligibility criteria:
inclusion criteria: - clinical hypertension, medically treated with no more than 2 drugs exclusion criteria: * body mass index above 35 kg/m2 * fasting blood cholesterol levels below 115 mg/dl * fasting blood glucose levels above 126 mg/dl * taking anyone of the angiotensin-converting enzyme inhibitors * anemia (hemoglobin below 13 g/dl in men and below 12 g/dl in women) * vitamin or nutraceutical intake in the last 30 days before the study enrollment * chronic gastrointestinal diseases * pregnancy and breastfeeding * garlic allergy * participation in another study 30 days before the study enrollment

Keywords: garlic nitric oxide angiotensin-converting enzyme antioxidant capacity endothelial function
the rapid trial: assessing point-of-care influenza and other respiratory virus diagnostics

Conditions: Respiratory Pathogens; Upper Respiratory Tract Illness; Lower Respiratory Tract Illness; Acute Respiratory Infection

Summary: the rapid trial is a randomized controlled trial that looks at the clinical impact of a rapid respiratory test in a pediatric emergency department. participants will be randomized to the intervention group - results available to medical providers, or the control group- results not available to medical providers.

the rapid trial is a randomized controlled trial of rapid respiratory viral testing in children presenting to an emergency department setting with acute respiratory symptoms. the patient cohort will be children 1 month to 18 years of age presenting to the children's hospital colorado (chco) emergency department with influenza like illness who are triaged as level 3, 4, or 5 by the emergency severity index, representing the typical patient population who are evaluated in an urgent care setting. all eligible participants will undergo a nasopharyngeal swab and point of care testing, and participants will be allocated 1:1 by computer-generated randomization to either the intervention group - test result available to providers, or the control group- test result not available (routine clinical care). the investigators will compare the clinical outcomes between the two groups.

Eligibility criteria:
inclusion criteria: 1. age 1 month to \< 18 years 2. for children aged 1 month to 12 months of age: presentation to the study sites with temperature \> 37.8°c or cough, sore throat, runny nose or nasal congestion 3. for children aged \> 1 year to 18 years of age: presentation to the study sites with influenza like illness, defined as temperature of \>37.8⁰c and at least one of the following: cough, sore throat, runny nose or nasal congestion 4. triage level 3,4,5 based on emergency severity index (refer to appendix b for algorithm) exclusion criteria: 1. respiratory symptom duration \> 14 days 2. previous enrollment in study within past 14 days 3. nurse-only visit 4. triage levels 1 and 2 based on emergency severity index
effects of tongue tamers as an early treatment of anterior open bite

Conditions: Tongue Habits; Open Bite

Summary: anterior open bite (aob) is a malocclusion that causes aesthetic, speech, feeding, and psychological concerns, emphasizing the significance of beginning treatment as soon as possible to correct the disorder. the main etiological determinants of aob include finger-sucking, pacifiers, and oral habits; hence, it is vital to use interceptive treatments focused on correcting and increasing bite stability during childhood to avoid the need for advanced therapy


Eligibility criteria:
inclusion criteria: * male or female patients in early mixed dentition period with age range 7-9 years * dental anterior open bite equal to or greater than 1 mm, * class i malocclusion * clinical signs of anterior tongue thrusting. exclusion criteria: * patients with skeletal open bite * posterior crossbite * tooth agenesis or loss of permanent teeth * crowding, * systemic diseases

Keywords: open bite tongue thrust habit breaking appliance
diagnostic efficacy of metagenomic next-generation sequencing in patients with spinal infections: a retrospective study

Conditions: Spinal Infection; Diagnositic Efficacy

Summary: comparing the diagnostic efficacy between traditional laboratory methods and second-generation high-throughput sequencing in patients suspected of spinal infections.


Eligibility criteria:
inclusion criteria: "patients suspected of spinal infections, as per the american infectious diseases society's 2015 criteria for primary vertebral osteomyelitis, were identified based on their clinical symptoms, laboratory tests, and imaging examinations. all cases included in the study underwent laboratory examinations, histopathological examinations, and second-generation high-throughput sequencing (metagenomic sequencing)." exclusion criteria: "the absence of laboratory examinations, histopathological examinations, and results from second-generation high-throughput sequencing (metagenomic sequencing)."
effect of air cleaner on the indoor allergen sensitized allergic rhinitis patients

Conditions: Allergic Rhinitis

Summary: this study aimed to assess the impact of air cleanser on allergic rhinitis patients and indoor air quality. air cleaners will be installed in the bedrooms and living rooms of the mite allergic rhinitis patients who aged 18-60 years. main parameters: - symptom medication score of allergic rhinitis supportive parameters: * visual analog scale of allergic rhinitis * quality of life score of allergic rhinitis * indoor air quality measurement * indoor allergen level measurement

the most important principle in the treatment of allergic diseases is to avoid or reduce exposure to the causative antigen. causative agents that induce allergic diseases or exacerbate symptoms are classified into indoor and outdoor allergens. house dust mites and pet's hair are typical indoor antigens. air pollution as well as allergens are important deterioration factors, and environmental management is essential for alleviating symptoms of allergic diseases. therefore, we are about to evaluate the impact of the air cleaner to the allergic rhinitis patients. a total of 45 patients will be enrolled in the study and a real air cleaner and a mock-up air cleaner will be randomly installed at ratio of 1: 1 to measure rhinitis symptoms and the changes in indoor air quality after 6 weeks of operation.

Eligibility criteria:
inclusion criteria: * adults between 19 and 65 years of age * allergy specialist diagnosis of moderate to severe persistent allergic rhinitis * retrospective rhinoconjunctivitis total symptom score higher than 7 * allergy against house dust mite: skin prick test, with a more than 3 mm wheal, serum specific ige higher than 0.35 kua/l measured by immunocap * who can read and write korean * participants those who voluntarily agreed to this study exclusion criteria: * allergy against seasonal allergens (tree, grass, weed pollens) * patients with rhinitis due to other causes (drug induced rhinitis or infectious rhinitis etc.) * patients with severe anatomical abnormality that may cause nasal blockage such as nasal septum deviation or nasal polyps * chronic systemic corticosteroids (≥ 3 months continuous use in past 12 months) * participants planning to move or change residence within the study period. * staying away from the home continuously for more than 5 days in the study period. * having air cleaner previously * having indoor smoker * if pregnancy test is positive or pregnancy is possible during study period. * any other reason the participants is deemed unsuitable for participation in clinical trials
cicero- a care home study of covid-19

Conditions: COVID

Summary: the primary objective of the study is to determine whether, at 21 days, care homes that implemented near-patient daily testing have a lower rate of confirmed cov-2 infections than care homes following the dhsc standard of care testing of symptomatic residents.

accurate, rapid, near-patient testing systems, such as q16+cov-2, allow for daily routine testing of residents, and of staff and visitors prior to entering the care home. daily cov-2 pcr testing with high analytical sensitivity (e.g., 2 copies per 8 µl sample) may detect infected residents and visitors before clinical symptoms are apparent. earlier detection may lead to earlier implementation of the uk standard of care protocol for infection prevention and control measures, thereby preventing the asymptomatic infected individuals from introducing and/or transmitting cov-2 within the care home. this should reduce the transmission by: preventing the introduction of the virus into care homes from external visitors e.g., gps (inward transmission) preventing the spread of the virus within care homes and preventing cluster development (internal transmission) preventing the outward spread of the virus from within care homes by infection of external visitors (outward transmission)

Eligibility criteria:
inclusion criteria: * persons resident or requiring access to the care home * capable of giving written informed consent, or if appropriate, having an acceptable individual capable of giving consent on the participant's behalf. exclusion criteria: * persons not providing informed consent or withdrawing consent at any time during the study. * persons requiring urgent and immediate access to the care home, for example medical staff attending emergency visits. * persons unable to provide nasal or oropharyngeal swabs for medical reasons.

Keywords: covid-19
screening of postpartum depression in egyptian women

Conditions: Postpartum Depression

Summary: the goal of this cross-sectional study is to assess the edinburgh postnatal depression scale as screening tool for postpartum depression among women delivering at egyptian tertiary health care system, university hospital, regarding prevalence and risk factors. participants of this study with fill the edinburgh postnatal depression scale and their socio-demographic, obstetric and psychological data will be collected and analysed. prevalence of postpartum depression in egyptian women will be assessed as well as the associated risk factors


Eligibility criteria:
inclusion criteria: all patients who underwent vaginal/cesarean delivery and reported for follow and willing to participate in the study. exclusion criteria: * patients who were unwilling to participate in the study. * patients who are having difficulties comprehending the questionnaire of the study. * women who were on psychiatric medication during pregnancy.
ultrasound and mammography for screening breast cancer in chinese women

Conditions: Breast Cancer

Summary: early detection of breast cancer through screening has been a common practice in the united states and several european countries for decades.it is effective in reducing the mortality of breast cancer and improving the postoperative quality of life of patients. mammography has been the standard imaging method for the screening, and in recent years, a supplemental ultrasound exam is also recommended.a prospective, multi-center, randomized trial is needed to define an optimal screening strategy that suits chinese women and the socioeconomics of china.


Eligibility criteria:
inclusion criteria: * written informed consent； * residence from community or working units exclusion criteria: * pregnancy； * lactation； * known metastatic cancer； * signs or symptoms of breast disease； * presence of breast implants, breast surgery within prior 12 months； * had mammography or ultrasound exam within prior 12 months * males.

Keywords: breast cancer screening mammography ultrasound
study on the safety of neladenoson bialanate, how it is tolerated and the way the body absorbs, distributes and gets rid of the study dug given as a single oral dose in participants with liver impairment and healthy participants matched for age-, gender-, and weight

Conditions: Pharmacology, Clinical

Summary: neladenoson bialanate is currently under clinical development for a condition in which the heart has trouble pumping blood through the body (chronic heart failure). liver impairment is a condition in which the liver is not working as well as they should. the goal of the study is to learn more about the safety of neladenoson bialanate, how it is tolerated and the way the body absorbs, distributes and excretes the study dug given as a single oral dose neladenoson bialanate in participants with liver impairment and healthy participants matched for age-, gender-, and weight


Eligibility criteria:
inclusion criteria: all subjects * male and female caucasian subjects between 18 and 79 years of age (both inclusive) with a body mass index above/equal 18.0 and below/equal 34.0 kg/m² subjects with hepatic impairment * subjects with documented liver cirrhosis confirmed by histopathology, e.g., previous liver biopsy, laparoscopy, ultrasound, or fibroscan * subjects with hepatic impairment as per child pugh system * subjects with stable liver disease during the last 2 months healthy subjects * healthy subjects with mean age and body weight not varying by more than ±10 years and ±10 kg from the groups of subjects with mild and moderate hepatic impairment, respectively. exclusion criteria: * medical history of continent ileostomy. * febrile illness within 1 week prior to admission to study center. * known hypersensitivity to the study drug (active substances or excipients of the preparation). * subjects with diagnosed malignancy within the past 5 years. * use of any systemic or topical medicine or substances which oppose the study objectives or which might influence them, in particular: starting from screening on, but minimum from 2 weeks before the study drug administration until the follow-up visit: * cyp3a4 inducers * cyp3a4 inhibitors * potent cyp2c8 inhibitors * major uridine diphosphate-glucuronosyltransferase isoenzyme 1a1 (ugt1a1) substrate (irinotecan) on the day of administration of neladenoson bialanate: * major breast cancer resistance protein (bcrp) substrates * regular daily consumption of more than 500 ml of usual beer or the equivalent quantity of of more than 2 units of alcohol in another form - intake of ethanol containing food and beverages from 48 h prior to admission to the study center until 96 h after study drug administration, afterwards not more than 2 units of alcohol per day until follow-up examination. * intake of food and beverages containing grapefruit or pomelo from 14 days prior to study drug administration up to the last time point of pk sampling. * therapies (e.g. physiotherapy, acupuncture, etc.) within 1 week before study drug administration. * positive urine drug screening. * positive results for human immune deficiency - abnormal (clinically significant) thyroid stimulating hormone (tsh).