Kornimate/medical-research-clean huggingface dataset:
ct evaluation of intimal flap mobility

Conditions: Aortic Dissection Type A

Summary: type a aortic dissection is an emergency condition, defined by the appearance of an intimal flap within the ascending aorta. urgent treatment is required, with surgical replacement of - at minima - the tubular portion of the ascending aorta. after surgery, a majority of patients will still have a residual aortic dissection involving the aortic arch and/or the descending aorta. long-term survival in these patients can be hindered by the apparition of an aneurysmal progression of the dissected aorta, with risk of rupture, thrombose and/or embolism. consequently, this condition requires frequent follow-up imaging examinations, usually by computed tomography angiography (cta), to monitor the extension of the dissection and the diameters of the dissected aorta. patient management is therefore based on passive follow-up of the disease, as no definitive clinical or imaging features can predict the potential evolution (or the absence of) towards an aneurysmal evolution. therefore, one can understand the important need for accurate predictors of aneurysmal dilatation of post-operative residual dissection. cta has the ability to visualize the intimal flap motion, by averaging at least 3 or 4 cardiac cycles over a non-gated arterial acquisition. this intimal flap mobility varies greatly between patients, between the localization and the extension of the dissection, and between acute and chronic dissections. it is thought that chronic dissections with immobile flap might be less prone to aneurysmal evolution. the investigators hypothesize that this mobility could be a prognostic marker for the evolution towards aortic dilatation: flap that would remain highly mobile after initial surgery could be an additional marker towards an aneurysmal evolution, while immobile flap could be on the contrary a marker of stability. intimal flap motion can already be qualitatively and quantitatively assessed in cta when ecg-synchronization is used. however, this technique has a limited availability and significantly increases the total radiation dose, therefore limiting its use in routine practice. being able to quantify this marker using routine non ecg-gated cta could be a significant addition to the literature, as it is currently unknown if this is feasible/relevant.


Eligibility criteria:
inclusion criteria: * major patient (≥18 years old) * ascending aorta replacement for aortic dissection, between 2010 and 2015 (timeframe established to allow for a significant follow-up period after surgery) * residual type b dissection after surgery availability of thin-slices good quality ct angiography before (at least one) and after (at least two) the surgery. exclusion criteria: * patient expressing opposition to participating in the study * patient under the protection of justice * patient under guardianship or curatorship

Keywords: aortic dissection type a post operative residual aortic dissection aneurysmal progression of the dissected aorta intimal flap mobility
study to evaluate the efficacy and safety of m518101 in subjects with plaque psoriasis

Conditions: Psoriasis

Summary: this study is to evaluate the efficacy and safety of m518101 in subjects with plaque psoriasis.


Eligibility criteria:
inclusion criteria: * who are able and willing to give signed informed consent * who are male or females aged 18 years or older with plaque psoriasis confirmed by the investigator. * who have up to 20% of body surface area (bsa) afflicted with plaques * who are neither pregnant nor breast-feeding, nor plan to become pregnant during the study. exclusion criteria: * who have a history of allergy to vitamin d3 derivative preparations or a history of relevant drug hypersensitivity. * who are pregnant or lactating. * who have any renal or hepatic insufficiency, or clinically significant cardiac, renal or hepatic disease. * who are not deemed eligible as determined by medical history, physical examination or clinical laboratory safety tests. * who have clinically relevant history or presence of any disease or surgical history other than psoriasis which is likely to affect the conduct of the study. * whose serum calcium levels exceed the upper limit of reference range * who have used any investigational medicinal product and/or participated in any clinical study within 60 days of randomization. * who have been treated with systemic therapy within 30days of randomization. * who have treated with biologics within 5 half-lives of the biologics before the day of randomization * who have been treated with topical therapy within 14days before the day of randomization.
virtual reality on pain and fear level during kirschner wires (k-wires) removal in children

Conditions: Fear of Pain

Summary: this study will be conducted to examine the effect of virtual reality applied during k-wire removal and dressing on the pain and fear levels that develop due to the procedure in children aged 7-12 years who apply to the orthopedic outpatient clinic.

technology-based methods have now begun to be used to control anxiety and prevent pain that may occur before, during and after diagnosis and treatment procedures in children. virtual reality (vr), which is among the technological products, can be used in non-pharmacological methods as well as pharmacological methods. it has been observed that vr, especially in children, creates an analgesic effect by mainly distracting the pain centers in the brain and evokes positive emotions with an anxiolytic effect.since children do not want to see the procedures to be performed on them, virtual reality used during the procedure is one of the methods of diverting attention from the environment they are in. this study will be conducted to examine the effect of virtual reality applied during k-wire removal and dressing on the pain and fear levels that develop due to the procedure in children aged 7-12 years who apply to the orthopedic outpatient clinic.

Eligibility criteria:
inclusion criteria: * being a child between the ages of 7-12 who will have the k wire removed * the child is not using glasses * the child must be at a cognitive development level that can respond to video selection. exclusion criteria: * having a disease that causes chronic pain * the child must have used medication that would have an analgesic effect in the last 24 hours before the application. * the child is wearing glasses * the child has a mental or neurological disability

Keywords: child kirschner wires pain fear virtual reality
effect of low-glycemic index meals intake on dm2 women under metformin therapy

Conditions: Diabetes Mellitus, Type 2

Summary: to compare the effect of low-glycemic index versus control lunches and dinners intake on indicators of satiety, metabolic parameters and liver steatosis degree on women with type 2 diabetes under metformin therapy.


Eligibility criteria:
inclusion criteria: * subjets with type 2 diabetes mellitus diagnosis under metformin therapy. * female sex. * aged 30 to 65 years. * body mass index (bmi) 22 to 34.9 kg / m2. exclusion criteria: * women with insulin-releasing drugs or insulin treatment. * patients with diabetic nephropathy, retinopathy, chronic kidney disease, stroke. * subjects with hypothyroidism without treatment. * individuals with food allergies or intolerances. * women who present an intake of ≥20 g of alcohol per day quantified through a closed consumption frequency survey. * patients with previously diagnosed hepatitis, hepatic cirrhosis or liver cancer.

Keywords: glycemic index nafld metabolic parameters satiety
dexmedetomidine enhancing the recovery after cardiac surgery

Conditions: Post-cardiac Surgery

Summary: enhanced recovery after surgery (eras) aims to facilitate a quicker and smoother recovery period following surgical procedures. the implementation of these protocols may lead to patients returning to their daily activities sooner, experiencing greater satisfaction with their care, and potentially encountering fewer complications, ultimately contributing to shorter hospital stays. however, a common challenge in the postoperative phase is postoperative delirium(pod). this complication can lead to both immediate and long-term cognitive impairments, negatively impact overall health outcomes, and increase the financial burden on the healthcare system. interestingly, dexmedetomidine, known as dxm, is a medication that selectively targets certain receptors in the brain and offers sedative properties with minimal impact on breathing. this characteristic is noteworthy because it may help regulate sleep patterns and support the preservation of cognitive function during the recovery period.


Eligibility criteria:
inclusion criteria: * patients of american society of anesthesiologists classification (asa) grade ii-iii; * patients who were planned to have coronary artery bypass graft (cabg); * patients were free of exclusion criteria. exclusion criteria: * patients with preoperative high risk for getting post operative delirium or sleep disorders, * patients with american society of anesthesiologists classification (asa) grade\>iii; * patients with heart failure, left ventricle ejection fraction of \<25%, * patients with uncontrolled diabetes mellitus, coagulopathy, or history of uncompensated renal or hepatic diseases
the effect of mindfulness meditation and virtual reality on laparoscopic cholecystectomy patients

Conditions: Gall Bladder Disease; Laparoscopic Cholecystectomy

Summary: this study aims to compare the effects of the theory of human caring based short-term mindfulness meditation and virtual reality on patients scheduled for laparoscopic cholecystectomy.

anxiety, fear and sleep disorders are frequently encountered conditions in preoperative patient evaluation. common postoperative problems include pain, sleep disturbances, nausea and vomiting. when these problems are not dealt with effectively, patient comfort and satisfaction are adversely affected, recovery time after surgery and total hospital stay are prolonged, and the time allocated to nursing care increases. today, it has gained great importance to try to manage these problems with pharmacological and non-pharmacological evidence-based approaches. in particular, nurses need to identify possible problems in both preoperative patient evaluation and postoperative patient follow-up and produce solutions for them. although it is stated in studies that using easy, effective and safe non-invasive methods such as meditation and virtual reality can reduce the possibility of complications, increase the comfort level of patients, improve the quality of post-surgical recovery, and thus make the surgical process successful, there is no evidence to defend its effectiveness more clearly. more based studies are needed.

Eligibility criteria:
inclusion criteria: * 18 years old and over, * to undergo laparoscopic cholecystectomy operation, * no orientation problem, * volunteering to participate in the study. exclusion criteria: * conversion from laparoscopic approach to open cholecystectomy in the operating room, * complications that may affect participation in the study, * taking the patient to the intensive care unit after surgery, * refusal to participate in the study.

Keywords: recovery mindfulness meditation virtual reality nursing care
forearm position in subpectoral biceps tenodesis

Conditions: Biceps Tendon Disorder

Summary: the investigators aimed to compare two different forearm positions, extension-pronation (ep) or neutral, for fixation of the long head of the biceps tendon (lhb) in biceps tenodesis.

long head of biceps pathologies have been regarded as a source of anterior shoulder pain and disability. tenodesis is preferable surgical choice for especially young patients to to eliminate anterior shoulder pain. the optimal position of the elbow and forearm during tenodesis is a debated topic. the investigators aimed to evaluate pain and strength loss after biceps tenodesis fixed at extension-pronation (ep) and neutral positions. the investigators aimed to find the most appropriate and anatomical arm position that gives better clinical and functional results.

Eligibility criteria:
inclusion criteria: -participants with diagnosis of chronic biceps tendinitis exclusion criteria: - participants who had undergone rotator cuff repair surgery

Keywords: biceps tenodesis forearm shoulder arthroscopy position
eeg characteristics of different sedation depths in neurosurgery patients

Conditions: Electroencephalography

Summary: gliomas are the most common primary intracranial malignancy, and behavioral experiments in patients with supratentorial gliomas under sedation have shown potential neurological abnormalities; however, these behavioral experiments are susceptible to external influences. therefore, more objective evidence is needed to support and extend the existing conclusions. the purpose of this study is to compare the eeg signatures (such as the eeg signal power) at various levels of anesthetics induced sedation in patients with supratentorial glioma in frontal lobe and in patients without intracranial-occupying lesion.


Eligibility criteria:
inclusion criteria: 1. patients with supratentorial glioma in right frontal lobe, and patients requiring general anesthesia without intracranial-occupying lesion; 2. aged 18-60 years; 3. asa i to ii; 4. all those who sign the informed consent form. exclusion criteria: 1. obese patients, bmi\>30kg/m2; 2. patients with mallampati class iii to iv airway anatomy; 3. combined with other neurological or psychiatric diseases; 4. combined with disturbance of consciousness; 5. previous intracranial surgery; 6. known or suspected cardiac dysfunction; 7. allergic to intravenous general anesthetics; 8. long-term history of analgesia, sedation and drug abuse.
bli850 vs an active control bowel preparation in adult subjects undergoing colonoscopy

Conditions: Colon Cancer

Summary: this is a randomized, parallel, multi-center, single-blind study, comparing bli850 to an fda approved bowel preparation in adult subjects undergoing colonoscopy.


Eligibility criteria:
inclusion criteria: 1. male or female outpatients who are undergoing colonoscopy for a routinely accepted indication, including: * evaluation of barium enema results * gi bleeding * anemia of unknown etiology * neoplastic disease surveillance * abnormal endosonography * inflammatory bowel disease * unknown diarrhea or constipation etiology * polypectomy * laser therapy * routine screening 2. at least 18 years of age. 3. otherwise in good health, as determined by physical exam and medical history. 4. if female, and of child-bearing potential, is using an acceptable form of birth control (hormonal birth control, iud, double-barrier method, depot contraceptive, abstinent, or vasectomized spouse). 5. negative urine pregnancy test at screening, if applicable. 6. in the investigator's judgment, subject is mentally competent to provide informed consent to participate in the study. exclusion criteria: 1. subjects with known or suspected ileus, severe ulcerative colitis, gastrointestinal obstruction, gastric retention, bowel perforation, toxic colitis, or megacolon. 2. subjects with impaired consciousness that predisposes them to pulmonary aspiration. 3. subjects who are undergoing colonoscopy for foreign body removal or decompression. 4. subjects with clinically significant electrolyte abnormalities based on visit 1 laboratory results. 5. subjects who had previous significant gastrointestinal surgeries (e.g. colostomy, colectomy, gastric bypass). 6. subjects who are pregnant or lactating, or intending to become pregnant during the study. 7. subjects of childbearing potential who refuse a pregnancy test. 8. subjects who are allergic to any preparation components 9. subjects who, in the opinion of the investigator, should not be included in the study for any reason, including inability to follow study procedures. 10. subjects who have participated in an investigational surgical, drug, or device study within the past 30 days.

Keywords: colonoscopy screening
the effect of kinesio taping tension on the pain threshold and tolerance

Conditions: PRESSURE PAIN THRESHOLD; PAIN TOLERANCE; KINESIOTAPING

Summary: the aim of this study was to investigate the effects of kinesiotape technique applied in different tensions on pain tolerance (pt) of healthy university students. 100 healthy and volunteer male individuals studying at mugla sitki kocman university faculty of health sciences will participate in the research. study protocol was approved by the ethics committee of mugla sitki kocman university. the study is designed as a randomized, controlled, double-blind study to be performed on 4 groups consisting of 25 individuals in each group (no tension(placebo), and 50%, 75%, 100% tensions of kinesiotape). kinesiotape will be applied over lateral epicondyle of the dominant extremities with diamond shape technique by a ktai®certified physiotherapist. pt's will be measured with j-tech algometer before, immediately and 30 minutes after taping by a different physiotherapist who will be blind to taping tension.

diamond shape banding method will be applied in a way that 4 bands of 2.5 cm width cut kinesio tape ends on top of each other, leaving the lateral epicondyle region exposed while the elbows are slightly flexed in the supine position. in the groups where different tensions will be applied, the middle points of the tapes will be stretched according to the amount of tensions, and the ends will be taped over each other without tension.in the placebo group, the tapes of the tapes will be applied tensionlessly without overlapping each other. algometer will be used in the assessment of pressure pain threshold and pain tolerance. pain severity felt at the level of pain threshold and pain tolerance will be evaluated with the visual analogue scale (vas). all measurements will be made before taping, immediately after taping and 30 minutes after taping, will be repeated 3 times and their average values will be recorded. there will be a 60 second rest period between each trial to avoid temporal sensitization. each assessment will be performed bilaterally by another physiotherapist who is blind to the band tension and has no experience with the kinesio banding technique.

Eligibility criteria:
inclusion criteria: * being a male university student over the age of 18 * volunteering for the study * filling out the informed consent form not having the knowledge and experience about kinesiotaping before exclusion criteria: * being diagnosed with lateral epicondylit and its treatment * having any neurological disease or systemic disease that disrupts sense / pain perception (diabetes, rheumatoid arthritis, peripheral vascular disease, etc.) * skin sensitivity to elastic banding * open wound, ulcer, fungal infection in the area to be taped * exposure to upper extremity and / or cervical injury in the past 6 months

Keywords: kinesiotaping
clinical progression of mild to moderate idiopathic pulmonary fibrosis (ipf) under a therapy with esbriet® (pirfenidone)

Conditions: Idiopathic Pulmonary Fibrosis

Summary: the purpose of the study was to assess the clinical outcome of patients with a mild to moderate ipf after a one-year therapy with esbriet® (pirfenidone).


Eligibility criteria:
inclusion criteria: adult patients with confident diagnosis of mild to moderate ipf, who had previously not yet been treated with pirfenidone exclusion criteria: hypersensitivity to the active substance or one of the other excipients of pirfenidone concomitant use of fluvoxamin severe hepatic impairment or end stage liver disease severe renal impairment (creatinine-clearance \<30 ml/min) or end stage renal disease requiring dialysis simultaneous participation in interventional studies previously treated with pirfenidone for longer than 30 days
the response of pathogens to the respective or combined treatment of srp and local minocycline in chronic periodontitis

Conditions: Chronic Periodontitis

Summary: to evaluate the respective or combinatory efficacy of locally delivered 2% minocycline (mo) and surface and root planning (srp) by assessing both clinical parameters and the loads of four main periodontal pathogens in treating chronic periodontitis.

in this randomized clinical trial, the investigators will evaluate the respective or combinatory efficacy of minocycline and scaling and root planning in the aspects of both clinical parameters \[pocket depth (pd) and sulcus bleeding index (sbi)\] and the loads of four main periodontal pathogens \[aggregatibacter actinomycetemcomitans (aa), fusobacterium nucleatum (fn), porphyromonas gingivalis (pg) and prevotella intermedia (pi)\]. real-time quantitative pcr (qrt-pcr) will be used as a powerful tool with high sensitivity and specificity to quantitatively assess target periodontal bacteria in a period of 7 days. the investigators will also try to correlate the reduction of either total or respective bacteria with the improvements of clinical parameters, with an aim to uncovering the potential microbiological mechanism accounting for the efficacy of a therapy.

Eligibility criteria:
inclusion criteria: * diagnosed with moderate or severe chronic periodontal disease, and exhibited bleeding on probing and attachment loss, with radiographic alveolar bone loss in four or more teeth exclusion criteria: * pregnant, had used antibiotics within the last 3 months, had periodontal therapy in the past 6 months or had systemic diseases such as heart disease or hypertension

Keywords: chronic periodontitis minocycline surface and root planning pocket depth sulcus bleeding index prevotella intermedia
remimazolam vs desflurane for general anesthesia for ablation of arrhythmia

Conditions: Remimazolam; Desflurane; Cryoablation; Arrhythmia; General Anesthesia

Summary: in anesthesia for ablation for cardiac arrhythmias, abrupt hemodynamic changes or fatal arrhythmias can be seen frequently. remimazolam is a novel ultra-short acting benzodiazepine that provides good hemodynamic stability compared to conventional anesthetic agents. this study aims to investigate whether remimazolam reduces vasoactive agent use during cryo/radiofrequancy ablation under general anesthesia, compared to desflurane(rct).


Eligibility criteria:
inclusion criteria: * =or \> 20 years * admission for general anesthesia for rfca or cryoablation procedure exclusion criteria: * no severe adverse effect history or hypersensitivity of benzodiazepines or its additives * acute alcoholic intoxication state * coma or shock state due to other condition than heart problem. * acute narrow-angle glaucoma

Keywords: remimazolam desflurane arrhythmia cryoablation,heart cardiovascular disease