Kornimate/medical-research-clean huggingface dataset:
a phase i study of anlotinib on pharmacokinetics to assess the effect of high fat diet in advanced cancer patients

Conditions: Advanced Cancer

Summary: the purpose of this study is to further study the pharmacokinetic characteristics of anlotinib in advanced cancer patients with high fat diet.


Eligibility criteria:
inclusion criteria: * histological documentation of advanced solid tumors( non-small cell lung cancer.soft tissue sarcomamedullary. thyroid carcinoma) * at least one measurable lesion (by recist1.1) * lack of the standard treatment or treatment failure * 20≤bmi≤25 * 18-70 years,ecog ps:0-1,life expectancy of more than 3 months * main organs function is normal * women of childbearing potential should agree to use and utilize an adequate method of contraception (such as intrauterine device，contraceptive and condom) throughout treatment and for at least 6 months after study is stopped；the result of serum or urine pregnancy test should be negative within 7 days prior to study enrollment，and the patients required to be non-lactating；man participants should agree to use and utilize an adequate method of contraception throughout treatment and for at least 6 months after study is stopped * patients should participate in the study voluntarily and sign informed consent exclusion criteria: * clear allergies to the study drug or its ingredients * had the disease to affect drug absorption and metabolism * patients with factors that could affect oral medication (such as dysphagia，chronic diarrhea, intestinal obstruction etc.) * brain metastases patients with symptoms or symptoms controlled \< 1 months * used any drugs inhibit or induce hepatic drug metabolic enzymes in 30 days before the study * patients with drug abuse history and unable to get rid of or patients with mental disorders * patients participated in other anticancer drug clinical trials within 4 weeks * patients with concomitant diseases which could seriously endanger their own safety or could affect completion of the study according to investigators' judgment
kinesiotaping in treatment of pes anserinus tendino-bursitis

Conditions: Pes Anserinus Tendinobursitis

Summary: the aim of this study was to determine the effects of kinesiotaping in comparison to nsaids and physical therapy in treatment of pes anserinus tendino-bursitis.

the treatment of pes anserinus tendino-bursitis includes refraining from aggravating activities, local modalities such as heat, ice, ultrasound (us), iontophoresis, phonophoresis, electrical stimulation (es), nonsteroidal anti-inflammatory drugs (nsaids) and injections with either corticosteroids or local anesthetics. another treatment that seems to have a significant effect on the improvement of the disease is kinesiotaping. kinesiotaping is a cotton strip with an acrylic adhesive that is used for treating athletic injuries and a variety of physical conditions. the therapeutic effects of the tape is to relax the overused muscles and in rehabilitation to facilitate the underused muscles. advocates claim that the wave pattern found on the kinesiotaping has a lifting effect on the skin which can diminish swelling and inflammation via improving circulation and reduce pain by removing pressure from pain receptors.

Eligibility criteria:
inclusion criteria: * patients with clinical diagnosis of pes anserinus tendino-bursitis. exclusion criteria: * previous history of trauma or surgery on the knee joint, * history of nsaids induced acid-peptic disease * systemic and rheumatic diseases

Keywords: kinesiotaping pes anserinus tendino-bursitis nonsteroidal anti-inflammatory drugs physical therapy
combi-elastography assessment of hcc recurrence after thermal ablation multi-center study

Conditions: HCC; Recurrence Tumor

Summary: combined f index, a index,att index and spleen stiffness to predict tumor recurrence in different liver settings after thermal ablation of hcc.

thermal ablation is one of the established method for hcc treatment. postoperative recurrence of hcc is one of the major factors leading to poor prognosis of hcc patients. most studies have shown that the risk factors of recurrence include tumor size, tumor number and intrahepatic spread, etc. besides, the carcinogenic effects of inflammatory activity and fibrosis in liver background caused by chronic hepatitis also be related to the recurrence. in the study, combi-elastography imaging technology , not only the f index which is related to liver fibrosis stage can be obtained, but also the a index which is related to inflammation activity can be measured, this may provide a more valuable method for tumor recurrence of early prediction.

Eligibility criteria:
inclusion criteria: * aged 18 to 80 years of age, and gender not limited;chronic hepatitis b patients;the lesions of liver have the histopathological diagnosis of hcc and within milan criteria;all lesions were performed thermal ablation surgery;sign the informed consent. exclusion criteria: * lesions that unrealized complete inactivation evaluation by the enhanced imaging;merging other systems' serious illness that can't cooperate with elastic imaging checking(such as heart failure, renal failure, such as mental illness);after liver transplantation patients;patients with pregnancy.

Keywords: thermal ablation elastography ultrasound recurrence predictive cancer model
double flap technique for macular hole

Conditions: Macular Holes

Summary: double flapping technique to close the macular hole.

recently, it is agreed to close the macular hole with the retinal innermost layer; which is called internal limiting membrane (ilm), in most cases, the hole closes. but, sometimes the ilm single flap might displace resulting in a persistent hole. therefore, the investigators tried to make two flaps utilizing ilm, and sometimes certain patients have a very thin membrane over the retina; it is called epiretinal membrane (erm). the investigators use the double flapping technique by utilizing erm; therefore, the ilm remains and can be used if the hole resists closing with the first surgical interventions. here, the investigators did not use any new materials with unknown side effects on the human retina. although the flap technique is well known; however, investigators are making a double flap to decrease the chance of persisting macular holes. the visual recovery will be appeared in the post-operative period, whether it is the same, better, or worse.

Eligibility criteria:
inclusion criteria: * full thickness macular hole exclusion criteria: * partial-thickness macular hole * vitreomacular traction

Keywords: double flaps
three-dimensional virtual imaging to improve the accuracy of standard ct-based nephrometric scores: a prospective multicentric observational study

Conditions: Kidney Neoplasms; Carcinoma, Renal Cell

Summary: study design: prospective multicentric observational sample size of the study: the estimated number of patients to enroll in the multicenter study is at least 270 patients (statistically calculated referring to the results of a monocentric analysis including 101 patients with the same design, already performed by the coordinator center). number of centers involved: considering a total number of patients enrolled of at least 270, number of centers to be involved: 5. study procedures: 3d virtual model rendering * ct-scan images sent in dicom format to medics (turin, italy) after anonymization. * dedicated online platform available to upload the anonymized ct images, after registration. * ct imaging processing by bioengineers and 3dvm building within 72 hours * 3d-pdf download from the same online platform nephrometric score assessment * all ct-scans and their 3dvmsevaluation in order to assess surgical complexity, as classified by the padua nephrometry score and its relative padua risk category. * for each center: * assessment of the padua score on the basis of the ct-scans (2d-ns) by one urologist; * assessment of the padua score on the basis of the 3dvms (3d-ns) by another urologist. surgical intervention and pathological assessment * dedicated expert surgeon for each center performing nss to all patients with the same surgical technique. * dedicated uro-pathologist for each center performing the histopathological evaluations of the specimens.


Eligibility criteria:
inclusion criteria: * four-phase (unenhanced, corticomedullary, nephrographic and urographic phases) contrast enhanced ct-scan exclusion criteria: * evidence of anatomical abnormalities, like horse-shoe shaped or ectopic kidney. * preoperative imaging inadequate to perform a 3dvm (such as those with a ct-scan with \>3 mm acquisition interval of the slices, or suboptimal difference of enhancement among the enhanced phases) or older than 3 months.

Keywords: minimally-invasive partial nephrectomy nephrometry scores 3d virtual imaging ha3d postoperative complications
optimalization of nephroprotection using n-acetylcysteine

Conditions: Chronic Kidney Disease; Proteinuria

Summary: the main purpose of the study is find whether the addition of n-acetylcysteine (antioxidant) to dual renin-angiotensin-aldosterone system blockade involving angiotensin converting enzyme inhibitor and at-1 angiotensin ii receptor blocker leads to the reduction of proteinuria, main prognostic marker of chronic kidney disease progression.

the renin-angiotensin-aldosterone system (raas) plays an important role in the progression of chronic kidney diseases (ckd), and inhibition of the raas with angiotensin-converting enzyme inhibitors (acei) and angiotensin ii type 1 receptor blockers (arb) may retard ckd progression. dual pharmacological blockade of the raas with acei and arb is recommended as a standard renoprotective management at least in patients with nondiabetic proteinuric ckd. however, neither acei nor arb, even in high doses or in concomitant usage, abrogate the progression of ckd completely. innovative approaches are needed to keep patients with ckd off dialysis. additional antioxidant (n-acetylcysteine) may prove to be such beneficial therapeutic concept. to shed more light on this issue, we performed a randomised open controlled study to evaluate the influence of triple n-acetylcysteine and raas therapy on surrogate markers of kidney injury, i.e. proteinuria, markers of tubular involvement and kidney fibrosis.

Eligibility criteria:
inclusion criteria: * chronic kidney disease * stable proteinuria above 300 mg/24 hours (no variations above 25% in the last 6 months) * normal or slightly impaired stable renal function defined as serum creatinine level below 1.7 mg/dl (egfr \> 45 ml/min) exclusion criteria: * nephrotic syndrome * steroids or other immunosuppressive treatment minimum during six months before the study * diabetes mellitus * potassium serum level \> 5.1 meq/l * albumin serum level \< 2.0mg/dl * creatinine serum level \>2 mg/dl * current diagnosis of heart failure new york heart association (nyha) class ii-iv * clinically significant valvular heart disease or second or third degree heart block without a pacemaker * history of hypertensive encephalopathy, cerebrovascular accident or transient ischemic cerebral attack * history of myocardial infarction, unstable angina pectoris, coronary bypass surgery, or any percutaneous coronary intervention * history of malignancy including leukemia and lymphoma (but not basal cell skin carcinoma) within the past five years * pregnant or nursing women * any surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of study drugs. * history of alcohol abuse * nsaid abuse (more than 2 doses per week) * known or suspected contraindications to the study medications, including history of allergy to ace inhibitors, at-1 receptor blockers and n-acetylcysteine

Keywords: proteinuria antioxidant n-acetylcysteine
advisory board on cancer, infertility and pregnancy

Conditions: Cancer in Pregnancy; Fertility Preservation; Cancer; Pregnancy

Summary: the advisory board on cancer, infertility and pregnancy provides a platform where physicians from all over the world can request recommendations regarding the medical care of pregnant women diagnosed with cancer or regarding fertility preservation. the platform will contain different national advisory boards, with their own coordinator and members, as well as an overarching international advisory board with an international coordinator and members from different national boards. to investigate the impact of this platform, a year after its launch, data regarding the incoming requests will be extracted from the website, as well as all recommendation letters.

the advisory board on cancer, infertility and pregnancy (abcip)-platform will be a web-based platform where clinicians from all over the world can request advice from a group of experts on the field of cancer and pregnancy. the platform will contain different national advisory boards, with their own coordinator and members, as well as an overarching international advisory board with an international coordinator and members from different national boards. clinicians can fill in a format (attached) requesting for advice, using only pseudonymized patient data after agreeing a disclaimer: all information filled in in the 'request advice' format needs to be regarded as anonymous or pseudonymous data. we recommend you to inform your patient and ask for approval when needed, based on the rules and regulations applicable in your country. the filled out request will be sent to the specific national board of their own country, and if no national board is available, to the overarching international board. . to investigate the impact of this platform, a year after its launch, data regarding the incoming requests will be extracted from the website, as well as all recommendation letters.

Eligibility criteria:
inclusion criteria: * pregnant women with a cancer diagnosis * women with a fertility related question after cancer diagnosis * postpartum cancer diagnosis * cancer treatment during pregnancy

Keywords: cancer in pregnancy fertility preservation
remote monitoring of patients with copd

Conditions: COPD

Summary: this clinical investigation will evaluate the patient-equipment interface and patient preference in the use of modern possibilities for remote monitoring of patients with copd in a personalized care approach.

the primary objective is to evaluate the impact and feasibility of tele monitoring and video contact in personalized care of moderate and severe copd patients. this should be compared to normal standards of care. the cross-over design evaluates the influence on general hrqol of this tablet and monitoring system.

Eligibility criteria:
inclusion criteria: * willingness to participate and provision of informed consent * diagnosis of copd * fev1/fvc (post bronchodilator) \<0.7 * gold severity grade d * fev, \< 80% predicted * cognitive ability relevant for the studies as judged by the investigator * living in their own home and able to manage their activities of daily living exclusion criteria: * rapidly progressing severe disease other than copd and copd-related diseases, influencing the health-related quality of life (hrqol) during the study time as judged by the investigator * long-term stay ( \>2 weeks) away from home during the study period, where there are no possibility to get internet connection * copd exacerbation during 1 month before start of study

Keywords: monitoring
a trial evaluating efficacy of aga2118 in postmenopausal women with low bone mass (artemis)

Conditions: Postmenopausal Osteoporosis

Summary: the primary objective of this study is to determine the effect of treatment with aga2118 versus placebo at month 12 on lumbar spine bone mineral density (bmd) in postmenopausal women with low bone mass.

this phase 2 dose-finding study will evaluate the safety, tolerability, and efficacy of aga2118 at a range of dosing regimens in postmenopausal women with low bmd at the lumbar spine, total hip, or femoral neck and no prior history of fragility fractures. this study includes a 12 month blinded treatment phase where participants will be randomized 1:1:1:1:1:1:1 to receive double-blind dosing regimens of aga2118 or placebo. at month 12, participants who have completed the double-blind portion of the study will continue on to a 12 month open-label period where they will be re-randomized based on their prior dosing regimen to either continue their current dosing regimen, receive a new dosing regimen, or discontinue treatment and be actively surveilled throughout months 12 to 24.

Eligibility criteria:
inclusion criteria: * healthy, ambulatory, postmenopausal women age ≥ 55 to ≤ 80. * bmd t-score of ≤ -2.5 to \> -3.5 at the lumbar spine, total hip, or femoral neck. exclusion criteria: * history of vertebral fracture, or fragility fracture of the wrist, humerus, proximal femur, or pelvis. * vitamin d deficiency. * known intolerance to calcium or vitamin d supplements. * untreated hyper- or hypothyroidism. * current hyper- or hypoparathyroidism. * elevated transaminases. * significantly impaired renal function. * current hypo- or hypercalcemia. * positive for hiv, hepatitis c virus, or hepatitis b surface antigen. * malignancy within the last 5 years. * diagnosis of a familial cancer syndrome or known genetic mutation that increases risk of cancer. * myocardial infarction or stroke within the past 12 months. * use of agents affecting bone metabolism.

Keywords: osteoporosis
effect of covid-19 pandemic on emergency surgery practice

Conditions: Emergencies

Summary: a retrospective study at a tertiary university hospital to determine the effect of the covid-19 pandemic on the emergency surgery practice in the hospital.

the investigators conducted a retrospective review of all the patients who were admitted to the surgical wards through the emergency department at the jordan university hospital in the periods from march 2020 to may 2020. the records were compared to those of the patients who were admitted in the same period from the year 2019. data collection includes the number of admissions, the reason for admission, the average of symptoms duration until admission, the age of the patients admitted, gender, type of management, and the average length of stay before discharging the patients.

Eligibility criteria:
inclusion criteria: * all patients who were admitted to the surgical wards via the emergency department during the study periods exclusion criteria: -
influence of dietary and palliative care consultation on the quality of life (qol), performance status, and nutritional status of cancer patients in bangladesh

Conditions: Cancer

Summary: cancer patients are more likely to have malnutrition, which has been associated with poorer quality of life, higher morbidity, mortality rates, and impaired efficacy and tolerance to therapy. malnutrition is thought to afflict the cancer patients, with weight loss and varied degrees of asthenia being the main symptoms. in fact, malnutrition can increase the risk of surgical complications such as anastomosis dehiscence, poor wound healing, morbidity, and mortality. quality of life is among the most important health issues for cancer patients. patients view it as a specific and complex type of patient-reported outcomes (pros) that considers their social, economic, psychological, and physical activities. the quality of life for cancer patients is often lower than for the general population. despite the fact that several studies in the western population have suggested a relationship between nutritional status and quality of life (qol). there aren't many reliable, in-depth studies on the effectiveness of nutritional testing and early malnutrition therapy, as well as to look at the nutritional health and quality of life of cancer patients in bangladesh. therefore, the aim of this study is to outline the influence of dietary and palliative care consultation on the quality of life (qol), performance status, and nutritional status of cancer patients in bangladesh. to conduct this randomized control trial (rct), data will be collected through 3 observations: baseline survey with two follow-up surveys on the following months from the selected cohorts of cancer patients who will be receiving cancer treatments. there will be two groups of cohort, one will be given nutrition and palliative care counselling will be given as intervention during each observation and another group will be without consultancy. "the european organization for research and treatment of cancer quality of life questionnaire version 3.0 (eortc-qlq c30)", "the patient-generated subjective global assessment pg-sga)" to estimate nutritional status, and "the eastern cooperative oncology group's (ecog) scale" to determine the performance status (ps) will be used as instruments to collect data.


Eligibility criteria:
inclusion criteria: * cancer patients under standard treatment, willing to participate, who can eat orally, and health indicators are measurable. exclusion criteria: * cancer patients under no standard treatment, not willing to participate, who cannot eat orally, health indicators are not measurable, and death.

Keywords: cancer dietary consultation palliative care quality of life performance status nutritional status
cognitive and brain development in adolescents with gilles de la tourette syndrome

Conditions: Tourette Syndrome in Adolescence

Summary: in children with neurodevelopmental disorders, adolescence is usually associated with a reshaping of the clinical picture and symptomatology. tourette syndrome (ts) is a paradigmal neurodevelopmental syndrome characterised by involuntary paroxysmal movements (motor tics) and vocalisation (vocal tics) often associated with various psychiatric disorders. the neuronal and cognitive mechanisms associated with ts symptoms improvement during adolescence, or the persistence in adulthood remains unknown, and this is what we aim to address in this study.

thus, the aims of the present project is threefold: aim 1: to evaluate the maturation of cognitive functions in adolescents with ts compared to typically developing adolescents. to achieve this aim, three distinct cognitive dimensions will be assessed in all subjects (patients and controls): (i) reward sensitivity and habit formation; (ii) cognitive impulsivity and action control and (iii) self-agency. aim 2: to identify neuronal correlates of cognitive function and brain development in health and disease. to achieve this aim, we will use a combined behavioural (as described in aim 1), (i) neuroimaging and (ii) tms approaches. aim 3: to predict clinical outcome . in this part of the project we aim to identify behavioural, imaging or neurophysiological markers of clinical outcome in patients with ts.

Eligibility criteria:
inclusion criteria: * tourette syndrome * ages 13 - 18 * acceptance to perform the brain mri * acceptance to perform the cognitive testing * acceptance to perform the tms measures exclusion criteria: * learning disability * incompatibility with mri procedure (metal body implants, pregnancy)
nutritional requirement for the severe trauma patients

Conditions: Trauma

Summary: after severe trauma, high caloric nutrition supplement do harm on metabolic and immunologic aspects.


Eligibility criteria:
inclusion criteria: * iss more than 15 score * older than 20 years old * patient who need parenteral nutrition more than 5 days exclusion criteria: * patients who have metabolic disease except for diabetes * patients who cannot resuscitated * very low body weight (\< 40kg)

Keywords: trauma nutrition hyperglycemia