Kornimate/medical-research-clean huggingface dataset:
treatment of plantar keratosis with medicinal plant in diabetic patients

Conditions: Keratosis Plantaris

Summary: this study evaluates the addition of medicinal plant in the treatment of diabetic foot keratosis. half of participants will receive medicinal plant and other half will receive a placebo.

keratosis in feet or plantar callosity is an injury caused by friction or pressure in certain location of the skin. this is a common problem faced by diabetic patients, which usually cause subcutaneous tissue maceration, which favors bacterial invasion. it is responsible for the development of abscesses and ulcers. ulcer is the main cause of non-traumatic amputation of the feet in diabetic patients. treatment with medicinal plants is an ancient practice. brazil has one of the richest floras in the world. brazilian ministry of health recommends the rational use of medicinal plants and encourage the use of this practice by health professionals. the medicinal plant used in this study is a keratolytic agent, healing, emollient, bactericide and fungicide. the purpose of this study is evaluate the effectiveness of this medicinal plant in the treatment of keratosis in diabetic patients. this study will be controlled, randomized, comparative with standard drug and double-blind. will be included in the study 90 adult diabetic patients type 1 or 2, with keratosis, both sexes, but do not show feet ulcerated lesions. patients will be randomised controlled trials in three groups, with 30 people in each, which will receive topical treatment with medicinal plant (treatment group, tg), salicylate 10% (salicylate group, sg) and vaseline cream (control group, cg). the treatment will be once a day, for 30 consecutive days. numerical scores will be made of the sites with keratosis and individual areas and global measures in the first, 30th days of treatment. the results obtained will be submitted to statistical comparison. this research will follow the standards set by resolution 466/12 of the national health council, the vale do sapucaí university, for research with human beings and will be conducted in accordance with the ethical recommendations of the declaration of helsinki.

Eligibility criteria:
inclusion criteria: - diabetic patients type 1 and 2 with plantar keratosis exclusion criteria: - feet ulcerated lesions

Keywords: callosities; keratosis; diabetes mellitus; plants, medicinal; herbal medicine; keratolytic agents
medroxyprogesterone in treating patients with endometrioid adenocarcinoma of the uterine corpus

Conditions: Endometrial Adenocarcinoma; Endometrial Adenosquamous Carcinoma; Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation; Recurrent Uterine Corpus Carcinoma; Stage I Uterine Corpus Cancer; Stage II Uterine Corpus Cancer; Stage III Uterine Corpus Cancer; Stage IV Uterine Corpus Cancer

Summary: this phase ii trial is studying how well medroxyprogesterone works in treating patients with endometrioid adenocarcinoma (cancer) of the uterine corpus (the body of the uterus, not including the cervix). hormone therapy using medroxyprogesterone may be effective in treating endometrioid cancer.

primary objectives: i. compare the efficacy of medroxyprogesterone, in terms of induction of histologic response, in patients with progesterone receptor-positive vs progesterone receptor-negative endometrioid adenocarcinoma of the uterine corpus. ii. determine the early and late changes in gene expression at 72 hours and 21 days in patients treated with this drug. iii. examine the mechanisms surrounding the dynamic changes in endometrial tumor cells by determining possible correlations among histologic response, steroid receptor status, immunohistochemical measures of growth and apoptosis, and gene expression profiles in patients treated with this drug. outline: this is a pilot, multicenter study. patients receive medroxyprogesterone intramuscularly once approximately 3 weeks before surgical hysterectomy. a subset of 15 patients has tissue collected by pipelle biopsy or curettage at baseline, 72 hours after medroxyprogesterone therapy, and during surgery for gene expression arrays. patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

Eligibility criteria:
inclusion criteria: * histologically confirmed primary endometrioid adenocarcinoma of the uterine corpus * all histologic grades and stages eligible * diagnosis by endometrial curettage or biopsy within the past 8 weeks * must have the initial tissue block or 16 unstained sections of 5 micron thickness available * performance status - gog 0-3 * no history of thrombophlebitis or thromboembolic disorders * no other invasive malignancy within the past 5 years except nonmelanoma skin cancer * no prior therapeutic progesterone or anti-estrogen therapy within 3 months before diagnosis * no concurrent aminoglutethimide * no prior cancer treatment that would preclude study therapy * no concurrent bosentan * no concurrent rifampin
standardising and simplifying the global leadership initiative on malnutrition (glim) for its more general application

Conditions: Malnutrition

Summary: this observational study of aims to test whether and how the results of glim change when using different approaches and methods to carry out its components.

the main questions the study aims to answer are: * what is the most effective pre-glim screening approach? * which of the simple, globally accessible muscle mass measurement methods works the best in the context of glim? * how does using simpler approaches to screening and muscle mass measurement affect the performance of glim in detecting subjective global assessment (sga) defined malnutrition and 1-year mortality? participants will be/have: * asked questions about their recent food intake and possible non-volitional weight loss * assessed for malnutrition with sga * weighed, and their height will be measured (if not already recorded) * their muscle mass measured with a measuring tape (mid-upper arm circumference and calf circumference) and bioelectrical impedance * their muscle function measured using hand grip strength * have their patient records looked at to extract their weight and height data (if present), diagnoses, routine blood test results, abdominal computed tomography (ct) scan (if present), dual-energy x-ray absorptiometry (dexa) scan (if present), 1-year mortality and personal identification code for documentation (the latter will be deleted when the study period is over).

Eligibility criteria:
inclusion criteria: * age of 18+ years * able and willing to sign the consent form * inpatients of the tartu university hospital * admitted within 72 hours before enrolment exclusion criteria: * age of \<18 years * inability or refusal to sign the consent form * pregnant or lactating women * more than 72 hours passed since admission * patients isolating with an infection

Keywords: glim criteria glim nutrition assessment nutrition screening muscle mass
co2 field saturating alternative techniques comparison

Conditions: Embolism Air Post-Procedural

Summary: prospective randomized study comparing three strategy of deairing (no co2 insufflation, co2 insufflation with non specific cannula, co2 insufflation with commercial dedicated diffuser) as regarding time to complete deairing measured from declamping via tee echo and neurological events at wake up

the impact of air bubbles into the cerebral circulation after open heart surgery has been a topic of discussion since the introduction of the heart-lung machine, and flooding the surgical field with co2, which is heavier than azote and oxygen but over ten times more soluble seems a promising technique to minimize the presence of air microemboli. however very few studies have been conducted to ascertain what is the most efficient way to administer this treatment, or even of this treatment really impacts deairing time and clinical neurological events. this study aims at comparing the use of co2 (administered in two different ways: a simple cannula, which might be prone to emulsioning air and co2 not reaching a complete co2 saturation and a specific commercial diffuser which states promises complete filed saturation) to the no-co2 standard approach. the primary end point will be time to complete deairing as measured by intraoperative transesophageal echo while the secondary end point will be the incidence of clinical neurological events the day after the operation.

Eligibility criteria:
inclusion criteria: isolated, elective aortic valve replacement or combined avr and cabg - exclusion criteria: * any other kind of operation * urgency
xpert mtb/xdr clinical evaluation trial

Conditions: Tuberculosis, Pulmonary; Tuberculosis, Multidrug-Resistant

Summary: find and partners intend to address the need for a multi- and extensively drug-resistant tuberculosis (m/xdr-tb) diagnostic solution for patients in settings with a high burden of drug-resistant tuberculosis (dr-tb) though the development, evaluation and introduction of an xpert mtb/xdr assay


Eligibility criteria:
inclusion criteria: * • age 18 years or above; * symptoms suggesting pulmonary tb, i.e. persistent cough (generally ≥3 weeks or as per local definition of tb suspect), and at least one of the following: * previously received \>1 month of treatment for a prior tb episode or * failing tb treatment with positive sputum smear or culture after ≥3 months of a standard tb treatment or * had close contact with a known drug-resistant tb case or * newly diagnosed with mdr-tb within the last 30 days or * previously diagnosed with mdr-tb and failed tb treatment with positive sputum smear or culture after ≥3 months of a standard mdr-tb treatment regimen patients meeting the above criteria will be screened by xpert mtb/rif or xpert mtb/rif ultra. tb patients meeting the following criteria will be included in the study: * a clear mtb-positive and rif-resistant or rif-sensitive result by xpert mtb/rif or xpert mtb/rif ultra * provision of informed consent; * production of an adequate quantity (\>3ml) of sputum exclusion criteria: * participants will be excluded from the study if informed consent is not provided.
measuring pharyngeal muscle improvements following behavioral swallowing exercises

Conditions: Dysphagia

Summary: the purpose of this study is to learn more about how exercise and protein supply affect swallow muscles. twenty healthy older adults will be recruited from local community centers, physician offices, and retirement communities via flyers. participants will complete 16 sessions of standard of care swallowing exercises 2 times per week for 8 weeks. all sessions will be conducted via zoom. during each session, a series of swallow exercises will be performed following a demonstration from a trained speech-language pathologist. participants will be referred to nyu langone health or white plains hospital, for a videofluoroscopic swallowing study, acoustic pharyngometry and measures of hand grip strength before and after the treatment protocol. patients will be able to select their preferred site for swallow study completion. results will inform the relationship between swallow exercises and pharyngeal muscles. all devices and exercises are established as safe and effective and are fda approved.

the natural next step in this program of research is to investigate interventions for reversing pharyngeal sarcopenia with the ultimate goal of developing novel therapeutic strategies to address this pervasive clinical issue. the exercise science literature suggests that sarcopenia in the limb muscles can be reversed through a combination of rigorous exercise and adequate levels of dietary protein. the innovative multi-disciplinary protocol, pepp (pharyngeal exercises plus protein), combines pharyngeal swallowing exercises selected for their known activation of the pharyngeal muscles with daily supplemental protein drinks. the research lab had documented successful improvements to swallowing physiology and pharyngeal sarcopenia in a pilot series of 5 older women using pepp. however the research was abruptly halted due to both ethical and feasibility challenges posed by the covid-19 pandemic. in response to these challenges, this study is seeking to establish the feasibility and effectiveness when the pepp intervention is delivered using telehealth (telepepp).

Eligibility criteria:
inclusion criteria: * age 65 and older * sarc-f score of ≥4 * functional hearing and vision status * access to reliable internet connection * availability of caregiver/family support and/or comfort with independent technology usage exclusion criteria: * known structural or neurological causes of dysphagia * not suitable to consume high levels of protein supplementation (i.e. moderate to severe kidney dysfunction)
participatory research to advance colon cancer prevention

Conditions: Colorectal Cancer

Summary: the overall goal of this study is to test strategies to raise rates of colorectal cancer screening among the latino population in a federally qualified health center that operates multiple clinics. this intervention study will test automated and live prompts to a direct-mail fecal testing program in two phases. in phase i (years 01 - 02), the investigators will tailor and define intervention components using a community-based participatory research approach called boot camp translation (bct). the ultimate design of the intervention will be defined by patient and provider feedback from bct. the investigators will then conduct a three-arm patient-randomized comparative effectiveness trial in two pilot clinics to compare 1) automated prompts (i.e., automated phone calls, text messages) to alert and remind patients to complete screening, 2) live prompts (i.e., live phone calls), and 3) a combination approach of automated plus live prompts. in phase ii (years 03 - 05), the investigators will spread and test the spread of the adapted intervention to additional clinics within the partnering health center using a two-arm main trial. both phases will be guided by an advisory group of clinicians, researchers, policy makers, and patients.

the study will fulfill the following aims: aim 1: develop personalized messages (e.g., phone scripts, text messages, patient portal prompts) and define an intervention using boot camp translation to increase colon cancer screening among latino populations. aim 2: assess the reach, effectiveness, and differences by subgroup (e.g., preferred language) of a three-arm colorectal cancer screening program among latino fqhc patients, in 2 clinics, through a patient randomized-controlled trial. in addition to usual care, the arms are: * automated prompts-an automated data-driven program for delivering fit kit prompts (using automated phone calls, text messages, and/or emails) to patients due for colorectal cancer screening. * automated plus live prompts-a higher-intensity program using automated, data-driven strategies for delivering fit kit prompts plus linguistically and culturally tailored live prompts. aim 3: test the spread of the program across additional clinics using a two-arm randomized approach and develop an implementation guide that includes outreach materials, strategies for incorporating patient input, and resources.

Eligibility criteria:
inclusion criteria: * persons aged 50-75 years and not up-to-date with colorectal cancer screening exclusion criteria: * persons having colorectal disease (e.g., ulcerative colitis or colectomy), personal history of colorectal cancer or colorectal disease, end-stage or life threatening diseases or, those known to be under hospice care or living in a skilled nursing facility may be excluded.

Keywords: colorectal cancer screening cancer screening pragmatic trial boot camp translation
ypsopump occlusion detection algorithm: collection of real-world data for in-silico evaluation of a new software algorithm to refine occlusion detection in subjects with type 1 diabetes using continuous subcutaneous insulin infusion

Conditions: Diabetes Mellitus, Type 1

Summary: a common difficulty related to the insulin pumps are occlusions of the insulin infusion set (iis). this study aims to evaluate the performance of a new software algorithm to detect catheter-occlusion in silico in order to refine the current automated occlusion detection algorithm of the mylife™ ypsopump®.


Eligibility criteria:
inclusion criteria: 1. written informed consent 2. subject is diagnosed with t1d 3. subject on csii (except patch pumps) for at least 6 months 4. subject using any type of insulin approved for mylife™ ypsopump®: fiasp®, novorapid®, humalog®, apidra®, lispro sanofi 5. subject using a cgm system for at least 6 months 6. age ≥ 18 7. subject willing to continue csii with mylife™ ypsopump® during the study 8. subject willing to use cgm system during the study 9. if the subject wants to use the cgm smartphone app instead of a receiver: subject ensures to use a compatible smartphone and is willing to share cgm for the duration of the study 10. hba1c \< 9.5% (based on last measurement by treating physician) exclusion criteria: 1. known allergy/hypersensitivity to medical grade adhesives and/or to physical activity tracker material 2. known severe nickel allergies 3. history of frequent catheter abscesses associated with pump therapy 4. treatment with \> 1000 mg of acetaminophen every 6 hours 5. treatment with hydroxyurea 6. serious acute or chronic disease besides diabetes mellitus or an anamnesis which might, in the opinion of the investigator, pose a risk to the subject, e.g. seizure disorder, adrenal disorder, dialysis for renal failure, cystic fibrosis, active infection 7. severe late complications of diabetes mellitus, e.g. severe macro- and/or micro-angiopathy (as determined by the investigator) 8. known hypoglycaemia unawareness 9. occurrence of self-reported severe hypoglycaemia event requiring third-party assistance within the last 6 months prior to study start 10. occurrence of self-reported diabetic ketoacidosis requiring healthcare assistance within the last 6 months prior to study start 11. participation in another investigation with an investigational drug or a pre-market medical device within the 30 days preceding and during the present investigation 12. female subjects: pregnancy, lactation period, lack of a negative urine pregnancy test (except in case of menopause, sterilization or hysterectomy), or unwilling to use a contraception during the study (for sexually active subjects of childbearing potential) 13. dependency from the sponsor or the clinical investigator 14. inability to follow the procedures of the investigation, e.g. due to language problems, psychological disorders, dementia, etc. of the subject

Keywords: continuous subcutaneous insulin infusion mylife™ ypsopump® occlusion detection algorithm
yoga intervention study on episodic tension type headache

Conditions: Episodic Tension Type Headache

Summary: the present study was designed to evaluate effect of yoga intervention on patients having frequent tension type headache.


Eligibility criteria:
inclusion criteria: * aged between 18 to 60 years * more than 5 but fewer than 15 headache episodes per month * headache intensity moderate to severe exclusion criteria: * patients on anti-psychotic, antidepressant or any prophylactic medication * pregnancy * taking psychotherapy or any other alternative medicine * migraine headache more than 1 day a month * pain disorder, psychiatric or medical disorder requiring immediate treatment, * headache due to sinusitis, eyestrain, cervical spondylosis and posttraumatic headaches
adaptive cognitive training on cognitive function in elderly hypertension patients in the community

Conditions: Hypertension; Condition; Aging

Summary: objective a growing body of evidence supports hypertension as a risk factor for cognitive decline. hypertension is significantly associated with accelerated cognitive decline, poorer cognitive function, and mild cognitive impairment and dementia. cognitive training is an effective intervention to improve cognitive function. however, the current cognitive training does not fully consider the different areas and degrees of cognitive function impairmentof older adults. this study aims to evaluate the effect of adaptive cognitive training on cognitive function of older adults with hypertension in the community. participants aged 60 years or older, diagnosis of hypertension, and cognitive function assessment showed no dementia. design the study was designed as a double-blind randomized controlled trial. 120 hypertension participants without dementia aged 60 years or older in shijingshan and haidian, beijing were included. participants will be randomized to adaptive cognitive training (intervention group) and placebo cognitive training (control group) at a ratio of 1:1. both training will be delivered by using pads with the same appearance. the interventions will last for 12 weeks and follow up to 24 weeks, and both groups will be followed up on the same time schedules for all outcome measurements. the primary outcome is changes in moca scores from baseline to the end of the 12-week intervention. the current trial has been reviewed by the ethics committee of plastic surgery hospital, chinese academy of medical sciences \& peking union medical college (approval number: 2024-162).


Eligibility criteria:
(1) could not complete neuropsychological tests; (2) suffering other disease or medication use might affect cognitive function, such as a new stroke within 6 months before baseline or use tranquilizers; (3) unable to use pads or unable to complete the training; (4) unacceptable or refuse to participate in cognitive training; (5) living in the same family with a subject who has been randomly assigned.