prospective cohort of non-infectious intermediate, posterior or panuveitis

Conditions: Non-infectious Uveitis

Summary: prospective, cohort, longitudinal, multicenter, non-randomized study of patients with non-infectious posterior segment uveitis or panuveitis, with a group of control patients (scheduled for cataract or vitreoretinal surgery) and constitution of biological collection.

description of the clinical characteristics and evolution in a large cohort of patients with non-infectious uveitis, allowing to identify prognostic or predictive factors of response after treatment of these different forms of non-infectious uveitis of the posterior segment or panuveitis (factors that are currently not well known). uveitis patients: * blood sample (20ml): additional 20 ml blood sample during the first visit and potentially during follow-up (if necessary) for the purpose of the biological collection; * ocular sample (aqueous humor, vitreous): if required by the clinical context for the needs of the biological collection; * specific imaging: adaptive optics or doppler holography, these procedures will be indicated on a case-by-case basis, at the investigator's discretion, and concern only patients with inflammatory vascular damage (5 to 10% of patients in the uveitis cohort); * quality of life nei-vfq 25: provided at the inclusion visit and at follow-up visits m3-v2, m12-v5 and m24-v7. control patients: * blood sample (20ml): additional 20 ml blood sample during the inclusion visit at the time of the surgical scheduled procedure for the needs of the biological collection; * ocular sample (aqueous humor, vitreous): considered as surgical waste, the tissue residues will be collected during the scheduled surgical procedure for cataract or vitreoretinal surgery for the needs of the biological collection;

Eligibility criteria:
inclusion criteria: uveitis patients: * adult patients (≥ 18 years); * non-infectious uveitis; * intermediate, posterior or panuveitis; * inflammatory activity requiring treatment with either one or more of the followings: * systemic corticosteroids or periocular or intravitreal injections of corticosteroids; * immunosuppressants: methotrexate, azathioprine, cyclosporine, etc.; * biotherapy: infliximab, adalimumab, tocilizumab; * patients with health insurance; * written informed consent obtained at enrolment in the study. control patients: * adult patients (≥ 18 years); * scheduled patients ( non-urgente procedure) for cataract or vitreoretinal surgery; * patients with health insurance; * written informed consent obtained at enrolment in the study. exclusion criteria: uveitis patients: * isolated anterior uveitis ; * inactive disease defined as: * absence of inflammatory chorioretinal and/or inflammatory retinal vascular lesion; * anterior chamber cell grade\< 0.5+; * vitreous haze grade \<0.5+; * pregnant or breastfeeding woman at the inclusion visit; * patient under legal protection (" curatelle " or " tutelle "); * patient denied freedom by a legal or administrative order. control patients: * pregnant or breastfeeding woman; * unscheduled (urgent) cataract or vitreoretinal surgery; * patient under legal protection (" curatelle " or " tutelle "); * patient denied freedom by a legal or administrative order.

Keywords: non-infectious uveitis