Kornimate/medical-research-clean huggingface dataset:
clinical massage therapy as a treatment for carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: once participants have been recruited, their grip strength shall be tested and they will all complete baseline questionnaires to assess functional status and symptom severity. following the recruitment stage, participants will be asked to attend medway maritime hospital once a week for four weeks, to receive the massage protocol. at the first session participants shall be asked to rate their pain (nprs), before receiving a massage treatment. this will be followed by instructions on how to perform self-massage, which they will be asked to complete daily over the four-week period, and record in a diary. at the remaining three sessions, participants shall just complete the nprs prior to receiving the massage treatment. after four weeks the group will be reassessed at the same orthopaedic clinic they attended prior to recruitment. they will be asked to complete a final pain score, record any changes in their condition, repeat the initial symptom questionnaire, and finally preform a grip strength test. the duration of four weeks was chosen as this is the time-frame within which the specific massage protocol advises a 'significant symptom improvement' should be seen.


Eligibility criteria:
inclusion criteria: * aged 18 years or above. * pain paraesthesia and/or hypoesthesia in the hand, in the area innervated by the median nerve. * participants must have a clinical diagnosis of carpal tunnel syndrome (cts). * participant must be able to comply with the study procedures. * participant must have attended the medway maritime hospital (kent), for assessment of the present condition. * participant is willing and able to give informed consent for participation in the study. * participant must not be contra-indicated for the receipt of massage. * participants must be able to speak and read english fluently. exclusion criteria: * participants who are receiving any additional treatment for their carpal tunnel pain that is not part of standard care (topical pain relief, bracing). * participants that have had any surgery on the anatomical sites relevant to the condition and/or treatment (neck, shoulder, arm, wrist, hand). * participants that have any suggestion of an additional condition related to carpal tunnel pain (i.e. previous trauma, pregnancy, etc). * planning to undertake any activities or lifestyle changes which may affect their levels of carpal tunnel pain (e.g. changing/ceasing occupation, alternative symptom therapy, adopting/ceasing a hobby).
a prevalence study of chronic widespread pain (cwp) among patients with rheumatoid arthritis (ra) and control population in tallinn and harjumaa county

Conditions: Chronic Widespread Pain

Summary: the chronic widespread pain (cwp) and fibromyalgia (fm) cause serious discomfort, but at the same time they are not life threatening and they cannot be detected by any laboratory tests. the problems connected with these conditions have gained little attention in estonia so far. it can be assumed that the cwp and fm often remain undetected and the sufferers live without treatment they need. so far, there are no data on the prevalence of the cwp and fm in estonia available. the goal of the current research is to assess the prevalence of the cwp and local pain syndromes among estonia's ra patients and among the control population in tallinn and harju county; also the factors connected with the presence of the pain and the pain treatment in use. at the same time there will be a similarly designed research conducted in jyväskylä central hospital, which provides the opportunity to compare results in estonia's and finland's research groups. the study on the distribution of the chronic pain among ra patients and control population will allow to assess the magnitude of the problem in estonia and to raise the awareness of physicians about cwp and significance of its treatment. performing the study will provide an experience which forms the base for further epidemiological and clinical research on cwp and fm


Eligibility criteria:
2000 ra patients from the east tallinn central hospital's and the north estonian regional hospital's in- and outpatients who live in tallinn or harju county the control sample will be found from the population register through matching by gender, age (the same year) and place of residence (living in the city or in the countryside) with the subjects from ra sample according to the official procedure. if required, the research subjects from the control sample will be contacted by a rheumatologist participating in the study. -

Keywords: chronic widespread pain fibromyalgia rheumatoid arthritis estonia
effect of shortening the palatal extension of the mouthguard on the degree of satisfaction of water polo players

Conditions: Mouth Protectors; Quality of Life

Summary: this study assessed the influence of a reduction of the palate extension of a custom-made mouthguard on the degree of satisfaction of elite water polo players. eighteen water polo players wore a custom-made conventional mouthguard or a reduced palate extension mouthguard during the training sessions and for competing for two weeks. the sequence was randomized to obtain one-half of the participants started the first week wearing the conventional mouthguard, and the other half wearing the shortened mouthguard. the participants rated the degree of discomfort in reference to speech, breathing, swallowing, nauseas/vomiting, pressure/pain, loosening, aesthetics, and athletic performance, in a 10-point scale, considering 0 no discomfort and 10 maximum discomfort. after each session, players also rated the perception of protection and the degree of satisfaction in a 10-point scale, considering 0 no protection/satisfaction and 10 maximum protection/satisfaction.

this crossover intervention study aimed to assess the influence of a reduction of the palate extension of a custom-made mouthguard on the degree of satisfaction of elite water polo players. eighteen water polo players participated in this study. two different custom-made mouthguards were made, a conventional one and a reduced palate extension mouthguard. they wore them during the training sessions and for competing one type of mouthguard for the first and fourth week and the other type of mouthguard for the second and third week. the sequence was randomized to obtain one-half of the participants started the first week wearing the conventional mouthguard, and the other half wearing the shortened mouthguard. the participants rated the degree of discomfort or inconvenience in reference to speech, breathing, swallowing, nauseas/vomiting, pressure/pain, loosening, aesthetics, and athletic performance, in a 10-point scale, considering 0 no discomfort/inconvenience and 10 maximum discomfort/inconvenience. after each session, players also rated the perception of protection and the degree of satisfaction in a 10-point scale, considering 0 no protection/satisfaction and 10 maximum protection/satisfaction.

Eligibility criteria:
inclusion criteria: * water polo players playing in maximum spanish category for the season 2017-2018 * obtaining written informed consent for participating in the project (model consent form) exclusion criteria: * players with dental caries, with periodontitis or with temporomandibular joint pain
vitalconnect vitalpatch ecg interpretation/arrhythmia detection

Conditions: Arrythmia, Cardiac

Summary: subjects in this study will wear the vitalpatch with the added ecg interpretation and arrhythmia detection features which will expedite the identification of patients whose condition may rapidly deteriorate as well as eliminate the majority of non-actionable alarms.

this project intends to validate, through comparative study, the output of new technologies (ecg interpretation and arrhythmia detection) to the vistacenter platform, aiming to replace current telemetry monitoring equipment. the new technology, through the previous mercy pilot study, has demonstrated greater accuracy in the detection of ventricular tachycardia patterns and other dysrhythmias/arrhythmias, as well as, reducing the volume of false alarms resulting in the mitigation of alarm fatigue experienced by bedside staff and monitor technicians.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old, * no skin trauma to the site where the patch will be applied * no known allergies to hydrocolloid or silicone based adhesives * admitted to mercy hospital washington cardiac unit on the 5th floor and have been placed in one of the assigned rooms and require cardiac/telemetry monitoring as ordered by their physician exclusion criteria: * pacemaker or implanted defibrillator (icd) * pregnancy * adults unable to provide informed consent * individuals who cannot read and understand english * prisoners * not recommended for use in mri

Keywords: ecg interpretation
the effectiveness of supported employment for people with severe mental illness: an rct in six european countries

Conditions: Psychosis

Summary: the primary aim of the study was to determine the effectiveness of a form of supported employment, individual placement and support (ips) compared to existing good quality rehabilitation and vocational services for people with psychotic illnesses in terms of 'open' employment outcomes (in the competitive labour market), and to examine its relative effectiveness in the context of different european welfare systems and labour markets. the primary hypothesis was that ips patients would be more likely to obtain open employment than control service patients. secondary hypotheses were that they would be in open employment for longer than the control patients, and that they would not spend more time in hospital.

an rct was conducted in six european centres: london (uk), ulm-guenzburg (germany), rimini (italy), zurich (switzerland), groningen (the netherlands) and sofia (bulgaria). patients were included if they had a diagnosis of smi (psychotic illness including bipolar disorder), were aged 18 to retirement age, had been ill and had major role dysfunction for at least two years, were living in the community at baseline, had not been in competitive employment in the preceding year and expressed the desire to enter competitive employment. they were randomly allocated to receive either ips or the 'vocational service' (control service). given the need to consider the impact of gender and work history on vocational outcomes (20), service allocation was stratified by centre, gender and work history (more or less than a month's competitive employment in the five years prior to baseline). randomisation was conducted centrally using minim version 1.5. a researcher at each centre recruited the patients, submitted them to the statistician for randomisation and received the allocation by email. the allocation sequence was concealed until the services had been assigned, but it was not possible for patients, professionals or researchers to be blind to service allocation thereafter.

Eligibility criteria:
inclusion criteria: * pscychotic illness of at least a years duration * unemployed for at least a year exclusion criteria: -

Keywords: vocational rehabilitation psychosis cross country comparison
rehabilitation of adolescents and young adults with congenital heart diseases

Conditions: Heart Defects, Congenital; Adolescent; Young Adult

Summary: the investigators aim to measure the impact of a rehabilitation program in congenital cardiology in terms of health related quality of life. the orginality of the rehabilitation program consists in its design : initial hospitalizationfor a short period of time (5 days) at the rehabilitation center, followed by 11 weeks of rehabilitation at home under the supervision of a specialized sports trainer.

adolescents and adults with congenital heart disease (chd) have reduced exercise capacity compared to the general population, even for "simple" heart disease. regular physical activity is known to reduce the risk of acquired heart disease. cardiac rehabilitation programs have been largely developed to manage adult coronary and heart failure patients, which is not yet the case routinely in patients, adults and children, carriers of dc. the investigators assume that patients who participate in this program will improve their quality of life compared to controls. the orginality of the rehabilitation program consists in its design : initial hospitalizationfor a short period of time (5 days) at the rehabilitation center, followed by 11 weeks of rehabilitation at home under the supervision of a specialized sports trainer .

Eligibility criteria:
inclusion criteria: * patient aged 13 to 25 years included * with a congenital heart diseases (chd) as defined in the international chd classification. * recent (\< 3 months) cardio-pulmonary exercise test (cpet)with maximum oxygen uptake (vo2max) \<80% of theoretical values and/or first ventilatory anaerovic threshold (vat) \<55% of vo2max. * consent of the adult patient or the parents or legal guardians of the minor patient. * beneficiary of the social security scheme. exclusion criteria: * uncontrolled arrhythmia. * cardiac surgery planned during the rehabilitation program. * severe musculoskeletal disorders. * severe intellectual disability that does not allow the quality of life questionnaire to be completed. * pregnancy. * patient who already underwent cardiac rehabilitation in the last 24 months. * all medical contraindications to perform a cardiorespiratory stress test. * uncontrolled heart failure (nyha iv) * obesity (bmi \> 30)

Keywords: cardiac rehabilitation congenital heart diseases heart defects, congenital adolescent young adult physical activity cardio-pulmonary exercice test oxygen uptake muscular deconditioning patient education as topic quality of life health knowledge, attitudes, practice
comparison of the biomechanical properties of the wall of an aneurysmal-altered abdominal aorta according to the results of in vivo ultrasound and an associated study of strength characteristics in vitro

Conditions: the Strength Properties of the Aorta in Vivo; the Strength Properties of the Aorta in Vitro; Regression Model of Aortic Strength Properties in Vitro and in Vitro

Summary: identification of the regression model between the strength properties of tissue and its ultrasonic spectral characteristics.

patients with identified aneurysms of the abdominal aorta, who are planned for surgical treatment, undergo an ultrasound examination of the abdominal aorta to assess the elastic properties of the aortic wall using ultrasound speckle tracking. intraoperatively, the accessible wall of the abdominal aortic aneurysm with a size of at least 10 cm2 is taken. and a section of the thrombotic cup of the aorta with a volume of up to 5 cm3. pathologically altered tissues extracted for research are subject to removal during a standard operation for prosthetics of the infrarenal aorta and have no clinical significance for the patient. in in vitro studies, the strength properties of the aneurysm wall are measured under uniaxial tension on a tensile testing machine, which makes it possible to evaluate the elastic properties of the test sample and obtain such parameters as young's modulus (slope of the strain-stress diagram in a linear section at small deformations), as well as limiting strain values and loading. the evaluation of the linearity boundaries of the surface under study, as well as the yield strength of the vascular wall and thrombotic masses, is evaluated under shear stresses using a rheometer. the tests will be carried out using special ground plane-to-plane instruments. to correlate the mechanical properties with the structural composition of the aneurysm tissue, spectral analysis of the tested tissues using the laser-induced fluorescence method and histological examination by staining the obtained sections for elastic fibers, fibrous tissues and calcification will be used.

Eligibility criteria:
inclusion criteria: * patients with an aneurysmal expansion of the abdominal aorta who are indicated for surgery. * patients who consented to participate in this study exclusion criteria: * chronic heart failure iii-iv functional class according to the nyha classification; * chronic decompensated "pulmonary" heart; * severe hepatic or renal insufficiency (bilirubin \> 35 mmol / l, glomerular filtration rate \< 60 ml / min); * polyvalent drug allergy; * malignant oncological diseases in the terminal stage with a predicted lifespan of up to 6 months; * acute violation of cerebral circulation;

Keywords: aneurysm wall strength speckle tracking shear yield strength
implementation study of the postoperative nausea and vomiting prediction rule

Conditions: Postoperative Nausea and Vomiting

Summary: this study evaluates whether the implementation of a prediction rule for postoperative nausea and vomiting changes physician behaviour, improves patient outcome and improves cost-effectiveness of treatment of postoperative nausea and vomiting.

background and objectives. so-called prediction rules (risk scores) have become increasingly popular in all medical disciplines. this will only rise with the introduction of electronic patient records as these will enhance their use. however, effects of implementation of such rules in daily care has hardly been studied. also not in anesthesiology. we developed and validated an accurate rule to preoperatively predict the risk of postoperative nausea and vomiting (ponv) in surgical inpatients. ponv causes extreme patient discomfort and occurs in even 30%-50% of all surgical inpatients. as routine administration of ponv prophylaxis is not cost-effective, a risk-tailored approach using an accurate prediction rule is widely advocated. before large-scale implementation, we aim to study whether such implementation indeed changes physician behavior and improves patient outcome. given the increase interest in prediction rules, another aim is to study general causes of successful/poor implementation of prediction rules in health care. design. cluster, randomized study in which 60 anesthesiologists and senior residents of the umc utrecht will be randomized to either the intervention or usual care group. study population. adult,elective,non-ambulatory,surgical patients undergoing general anesthesia of umc utrecht. intervention. implementation of risk-tailored ponv strategy (use of the ponv prediction rule with suggested anti-emetic strategies per risk group) in current care. outcomes. primary:incidence of ponv in first 24 hours. secondary:change in anesthesiologists' behavior in terms of administered anti-emetic management, cost-effectiveness of intervention, attitudes of physicians towards prediction rules in general. sample size. 11,000 economic evaluation. estimation of incremental costs per prevented ponv case.

Eligibility criteria:
inclusion criteria: * adult patients * undergoing elective surgery * general anesthesia exclusion criteria: * emergency surgery * postoperative transfer to icu

Keywords: implementation of prediction rules decision support systems, clinical ponv emesis nausea vomiting postoperative implementation prediction rule impact study decision support clinical decision support
oral and intravenous iron in patients postoperative cardiovascular surgery under extracorporeal circulation

Conditions: Anaemia

Summary: anaemia is a common postoperative problem of cardiovascular surgery after cardiopulmonary bypass (cpb). because of this the need for hemoderived blood transfusions is high. the purpose of this study was to compare the clinical efficacy of intravenous and oral iron in anaemia and the impact of the iron on the transfusion rate in postoperative cardiovascular surgery under extracorporeal circulation.

prospective double dummy triple blind study of 159 patients undergoing cpb; randomised in 3 groups treated with iron intravenously (iv) (group i), with iron orally (group ii) controlled with placebo (group iii). patients from group i were treated with iv iron sucrose , three doses of 100 mg of iv iron every 24 hours during postoperative hospitalization and 1 pill/24 h of oral placebo during the first month after discharge. group ii was programmed to receive 1 iron pill orally every 24 hours pre and postoperatively and up to one month after discharge and a placebo while hospitalized. group iii was programmed to receive an oral and iv placebo pre and postoperatively. variables were collected preoperatively, at operation room and at intensive care unit admission and discharge, at postoperative floor discharge and at one month after surgical discharge.

Eligibility criteria:
inclusion criteria: * men and women ≥ 18 years of age * patients subject to elective cardiac surgery under extracorporeal circulation * patients without previous anaemia, susceptible of treatment * patients without need of blood transfusion preoperative * patients providing written informed consent * patients who are able to complete all study visits per protocol exclusion criteria: * patients subject to elective cardiac surgery, but without extracorporeal circulation * patients who were treated with fibrinolytic therapy 48 hours before the surgery * patients with history of impaired renal function, (e.g., calculated creatinine clearance \<50 ml/min/1.73 m2) * patients operated of active endocarditis * redo-surgery patients * women who are pregnant or lactating * patients with clinical of digestive bleeding * patients with vitamin b12 deficit * patients with ferropenic anaemia * patients with clinical history of asthma or allergy * patients with active infection * patients who are included in another clinical study * patients with hepatic disease * patients with history of allergy to iron * patients unlikely to adhere to protocol follow-up

Keywords: cardiac surgery extracorporeal circulation anaemia intravenous iron oral iron
quality of life in chronic arthritis

Conditions: Ankylosing Spondylitis; Rheumatoid Arthritis

Summary: chronic joint complaints are prevalent in clinical practice. if chronic arthritis such as rheumatoid arthritis (ra) or ankylosing spondylitis (as) is not adequately controlled, it can not only affect patient's working ability but also produce indirect cost in patient's family. quality of life will also be affected. health-related quality of life issues are assuming increasing importance in chronic rheumatic diseases. however, studies on quality of life in rheumatic patients are limited. factors related to quality of life are not clear. application of quality of life measurement for improving clinical care of ra and as patients is still difficult. the objective of this study was to evaluation the validity of eq-5d life quality measurement in chronic arthritis patients in taiwan. factors associated with life quality will be addressed. this will also provide useful information for public health policy making.


Eligibility criteria:
inclusion criteria: * patients with rheumatoid arthritis or ankylosing spondylitis exclusion criteria: * patients with mental illness which interfered with questionaire answering

Keywords: ankylosing spondylitis disease activity eq-5d quality of life rheumatoid arthritis