Kornimate/medical-research-clean huggingface dataset:
cash- children active to stay healthy

Conditions: Childhood Obesity; Inflammation

Summary: the purpose of this study is to examine the effects of high intensity interval exercise (hiie) on inflammation and endothelial dysfunction found in children with obesity. our working hypothesis is that, compared with obese children prescribed moderate exercise, obese children prescribed hiie will demonstrate greater improvements in endothelial function and inflammatory markers following a 6-week exercise intervention.

obesity, even in children, is generally accompanied by a state of chronic inflammation. to combat childhood obesity, clinicians and scientists recommend lifestyle interventions that include increased physical activity and exercise in an attempt to promote weight loss and, consequently, decrease comorbidities associated with excess adiposity. more importantly, it appears that the influence of regular exercise may offer children with obesity a multitude of health benefits, independent of weight loss. however, the intensity of exercise required to elicit significant health benefits is still unclear. therefore, the aim of the present project is to study the influence of high intensity interval exercise (hiie) on the existing inflammatory state found in obesity. specifically, the proposed project will examine endothelial function and markers of inflammation, such as tnfa, il-6, hscrp, and adiponectin, in children with obesity before and after an exercise intervention. the data will then be used to determine if changes in these values differ in magnitude based on the intensity of exercise. children with obesity will be randomized into either moderate exercise or hiie groups, and attend sessions 3 times per week for 6 weeks. the moderate group will cycle continuously for 30 minutes at 65%-70% of maximal heart rate and the hiie group will perform ten, 2-minute bouts at 90%-95% of maximal heart rate. outcome measures of body composition, aerobic capacity, blood lipids, glucose metabolism, endothelial function, and inflammation will be measured pre- and post-intervention. results may help in establishing exercise protocols not only for children with obesity, but also other inflammatory diseases such as diabetes, cancer, and arthritis.

Eligibility criteria:
inclusion criteria: * 13-17 years old * obesity (defined as as bmi≥ 95th percentile for age and sex as defined by the centers for disease control exclusion criteria: * active participation in ≥30 minutes of vigorous exercise more than 2 days per week * participation in an organized combined diet/exercise weight loss intervention * acute inflammatory disease or febrile illness * recent trauma or injury * asthma requiring steroid use or that has resulted in hospitalization within 3 months prior to enrollment * chronic disease known to affect inflammation (e.g. lupus) * any renal, heart, or liver disease

Keywords: childhood obesity inflammation endothelial function exercise
a comparison of hemorrhagic and ischemic strokes among blacks and whites

Conditions: Ischemic Stroke; TIA; Hemorrhage

Summary: our primary goal is to study temporal trends in the incidence rate, causes, treatment, and outcome of stroke among a large biracial metropolitan population of 1,349,351, of whom 215,611 (15%) are black (2000 census). such data are critical for the planning, intervention, and evaluation of public health efforts to decrease the mortality and morbidity due to stroke in the united states. we have completed this goal for 1993-94, 1999, 2005, 2010 and 2015. we are in the process of collecting this data for 2020. in the 2020 study period we will also be ascertaining 3 year recurrence rates for all incident stroke events.

for calendar years 1993-94, 1999, 2005, 2010, 2015, and 2020 we will or have identified every hospitalized or autopsied stroke and transient ischemic attack (tia) at all regional hospitals in our region. we will also estimate the number of non-hospitalized strokes and tias by screening for potential cases at more than 100 outpatient sites throughout five counties in greater cincinnati/northern kentucky. we plan to identify and abstract detailed information from the medical record for every potential case. these results will be compared with data from all stroke patients identified by similar methodology in all study periods. in addition, we have interviewed 1500 ischemic stroke patients and/or their families in the study periods 1999-2010 to obtain detailed information including demographic information, functional outcome and quality of life, access to and type of rehabilitation therapy, social support, caregiver availability and health status, access to post-hospital care, health insurance status, current health status, medications, prior risk factors, and knowledge about stroke signs and symptoms. we also obtained genetic material via a blood sample for most of this cohort.

Eligibility criteria:
inclusion criteria: * ischemic stroke * occurred in 1999/2005/2010 * \>18 years old * resides in 5 county region exclusion criteria: * \<18 years old * resides outside 5 county region * inability to consent or have legal proxy consent

Keywords: stroke ischemic tia hemorrhage incidence case-fatality risk factors genetic
early mobilization of patients with community-acquired pneumonia

Conditions: Pneumonia

Summary: pneumonia is a common health problem.this thesis may clarify whether early mobilization influence the time these patients are hospitalized, whether they are rehospitalized and whether it is possible to reduce the mortality rate.

pneumonia is a common health problem. more than 100,000 danes contract pneumonia every year, and around 15,000 of these are hospitalized. the main treatment is antibiotics. an american study indicates that patients who are mobilized early are hospitalized for a shorter period of time. the objective of the thesis is: to determine the effect of mobilization within 24 hours after hospitalization of patients with pneumonia. the result will be number of hospitalization days, rehospitalisation and mortality. patients with pneumonia hospitalized in the period 1 september 2012 - 28 february 2013 in the medical centre, lung unit 204b at vendsyssel hospital will be included in the project. within the first 24 hours of hospitalization, they will be tested by a physiotherapist and mobilized. there are significant costs associated with the treatment of patients with pneumonia - both economic costs and human costs. this thesis may clarify whether early mobilization influence the time these patients are hospitalized, whether they are rehospitalized and whether it is possible to reduce the mortality rate.

Eligibility criteria:
inclusion criteria: * patients with community-acquired pneumonia exclusion criteria: * dementia

Keywords: mobilization physiotherapy community-acquired pneumonia
influence of medication on functional connectivity

Conditions: Prescription Drug Abuse (Not Dependent)

Summary: this study will assess the effects of acute low-dose opioid administration on functional neuroimaging measures in healthy individuals

this study will assess the effects of acute low-dose opioid administration on functional neuroimaging measures in healthy individuals (n=40, 20 male, 20 female). the objective of this research is to develop an understanding of factors that may influence individual variability on resting state functional connectivity in response to low-dose opioid administration with the longer term aim of understanding addictions vulnerability. specifically, the proposed pilot research will explore the effects of single dose of oxycodone (15mg) on resting state functional connectivity and other common neuroimaging measures (e.g., diffusion mri, structural mri).

Eligibility criteria:
inclusion criteria: 1. males or females, ages 18-30 2. for women of a child-bearing age, acceptable birth control methods or a negative pregnancy test prior to mri scanning 3. ability to provide written, informed consent 4. eligibility and willingness to participate in fmri scanning and to receive oxycodone 5. normal weight, as indicated by a body mass index (bmi) between 18.5 to 25 exclusion criteria: 1. current dsm-5 axis i disorder 2. any psychotropic medication or medication known to interfere with metabolism of opioids 3. medical contraindication to participate in study activities (acute low-dose opioid admin) as determined by study physician 4. known family history (first-degree relative) of opioid-use disorder or alcohol-use disorder 5. not eligible for mri scanning 6. positive drug screen 7. recent (past 6 months) medical or non-medical opioid-use 8. current or previous chronic pain disorder 9. significant lifetime use of prescription opioids (\>7 days of consecutive medical use or nonmedical use on more than 5 occasions)
study of oral atogepant tablets to assess safety and efficacy in adult participants with migraine

Conditions: Migraine

Summary: a migraine attack is a moderate or severe headache that usually occurs on one side of the head and is often accompanied by throbbing, sensitivity to light, sensitivity to sound, nausea, or other symptoms. the main goal of the study is to see if atogepant is effective, safe, and well-tolerated in treating migraine attacks quickly. atogepant is a medicine currently approved for the preventive treatment of migraine in adults and has been shown to be effective and well tolerated when taken daily to prevent migraine attacks. this study includes double-blind phase means that neither the participants nor the study doctors know who is given which study treatment (atogepant or placebo) followed by an open-label phase meaning that both participants and study doctors know which study treatment is given. all participants will receive atogepant during the open-label part of the study. this study will include 1300 participants aged 18-75 years with a history of migraine at approximately 160 sites across the world. all participants will receive both atogepant and placebo to treat qualifying migraines. at the start of the study, participants will be randomized to 1 of 4 dosing sequences to determine when they will receive atogepant and when they will receive placebo during the study. after treating 4 qualifying migraine attacks, participants will receive open-label atogepant for any additional migraine attacks they have until the end of the study (week 24). there may be a bigger responsibility for participants in this study than there would be in participants receiving standard of care treatment. participants will attend regular visits during the study at a hospital or clinic, as well as telephone visits, and the effects of treatment will be checked by completion of questionnaires in an electronic diary, medical assessments, blood tests, and checking for side effects.


Eligibility criteria:
inclusion criteria: * history of migraine (with or without aura) according to the international classification of headache disorders 3rd edition (ichd-3) for \>= 12 months prior to visit 1/screening. * history of 2 to 8 migraine attacks of moderate to severe headache pain in each of the 3 months prior to visit 1/screening per investigator judgment. * migraine onset before the age of 50. * history of migraines lasting between 4 and 72 hours when untreated or treated unsuccessfully and migraine episodes separated by at least 48 hours of headache pain freedom. exclusion criteria: * history of an average of 15 or more headache days per month in the 6 months prior to visit 1/screening per the investigator's judgment, or a current diagnosis of chronic migraine as defined by ichd-3. * require hospital/emergency room treatment for migraine attacks on 3 or more occasions within 6 months prior to visit 1/screening.

Keywords: migraine atogepant eclipse qulipta aquipta
depression and quality of life in chronic heart failure patients and the caregivers

Conditions: Chronic Heart Failure (CHF); Anxiety and Depression; Quality of Life (QOL); Exercise

Summary: anxiety and depression are often present in patients with chronic heart failure (chf). this study aimed to evaluate the influence of anxiety and depression on the physical function, disability, and quality of life (qol) in chf. this study examined the effects of 8-week home-based exercise on these parameters, and investigated the correlations between these outcome changes.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of chf for more than 6 months (nyha classes i-iii) * medically stable for at least 3 months exclusion criteria: * malignancy * psychiatric disease, primary neuromusculoskeletal or respiratory diseases that affected the assessment of functional or exercise capacity * changes in medication occurred during the study period

Keywords: chronic heart failure (chf); anxiety and depression; quality of life (qol); exercise
preventive intervention value of dcb in vulnerable coronary atherosclerotic plaques

Conditions: Acute Coronary Syndrome

Summary: the passivate-cap study is an investigator-initiated, prospective, randomized, multicenter, open-label superiority trial focusing on acute coronary syndrome (acs) patients with nonflow-limiting vulnerable plaques in nonculprit vessels. in this study, eligible patients were randomized at a 1:1 ratio into two groups: patients who received guideline-directed medical therapy (gdmt) and patients who received gdmt combined with a drug-coated balloon (dcb). in this study, the use of pcsk9 inhibitors was limited to inclisiran. the primary endpoint was the minimal lumen area of the target lesion 1 year after randomization. the secondary endpoints encompass a range of factors, including the proportion of patients with vulnerable plaques in the target vessel, fibrous cap thickness, lipid core arc of the target lesion, minimal lumen area of the target vessel, and extent of ldl-c reduction in patients treated with inclisiran.


Eligibility criteria:
inclusion criteria: age ≥ 18 years diagnosis of acs with the intention to undergo ica there exists a nonculprit lesion characterized by a single diameter stenosis greater than 50% in the major coronary artery segments (with diameters ranging from 2.75 to 4 mm). qfr value \> 0.8 the oct examination suggests vulnerable plaques with a fibrous cap thickness of \ 180° presence of macrophages lesion length ≤30 mm provide informed consent life expectancy greater than 1 year exclusion criteria: patients with three or more target lesions or with two target lesions in the same coronary artery left main stem lesions ostial lesions thrombotic lesions severe calcification or angulated lesions true bifurcation lesions requiring stent implantation advanced heart failure (nyha iii-iv) ischemic stroke in the past 6 months or any history of cerebral hemorrhage at any time severe valve disease or valve disease that may require surgical or percutaneous valve replacement coronary artery anatomy obstructs the complete imaging of the segment of interest (including at least 5 mm beyond the narrow ends). diffuse coronary artery disease or the presence of ≥1 untreated nonculprit lesion (nonculprit blood flow-restricting lesion planned for staged pci). history of myocardial infarction, cabg, or pci coronary artery anatomy not suitable for pci the potential comorbidity that may impact the completion of the trial process. the planned major surgery requires discontinuation of dapt. history of pcsk9 inhibitor (such as evolocumab or alirocumab) use within 90 days prior to the first study visit. exposed to inclisiran or any other non-pcsk9 monoclonal antibody targeted treatment within the 2 years preceding the initial study visit, whether as an investigational drug or a marketed medication. history of allergy to the investigational drug, its excipients, or other sirna drugs females of childbearing potential, defined as all female subjects physiologically capable of becoming pregnant, unless they are using effective contraception during the administration of the investigational drug
olfactory decision-making and deprived sleep

Conditions: Sleep Deprivation

Summary: this research study will use magnetic resonance imaging (mri) and olfactory stimuli to better understand the connection between sleep deprivation, brain activity, and olfaction in humans.


Eligibility criteria:
inclusion criteria: * at least 18 years old * fluent english speakers exclusion criteria: * history of neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.) * history of psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, alcoholism, etc.) * significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.) * cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.) * use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.) * smell or taste dysfunction * history of severe allergies requiring hospitalization for treatment * history of severe asthma requiring hospitalization for treatment * habitual smoking * history of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.) * dieting or fasting * history of sleep disorders (e.g., obstructive sleep apnea, narcolepsy, insomnia, etc.) magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.) * electronic implants (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.) * history of metal working without proper eye protection, or injury with metal shrapnel or metal slivers * left-handedness * claustrophobia
pomegranate juice effect on oxidative stress in infertile women during ivf treatment

Conditions: PCOS; Endometriosis; Advised Maternal Age; Male Factor Infertility

Summary: tte investigators estimate pomegranate supplementation effect on oxidative stress in infertile women with pcos, endometriosis and advanced maternal age during ivf treatment. the primary aim is to compare the obtained oxidative stress markers in follicular fluid with pomegranate supplementation vs control.


Eligibility criteria:
inclusion criteria: * patients undergo ivf treatment with diagnosis of pcos/endometriosis/mf or ama exclusion criteria: * patients who do not meet the inclusion criteria, as above
online cognitive behavioral intervention program for hong kong people with social anxiety disorder

Conditions: Social Anxiety Disorder

Summary: this study developed an online counseling program called "ease online" for hong kong people with social anxiety disorder. the program effectiveness was evaluated by a randomized controlled trial in reducing social anxiety and improving quality of life of the participants. the 3- and 6-month maintenance effects were also tested.

social anxiety disorder (sad), also known as social phobia, is one of the most common mental disorders worldwide. in hong kong, the 12-month prevalence of sad is 3.2% (lee, lee \& kwok, 2005) with more than 230,000 sufferers. however, only 8.7% of sad sufferers have sought medical treatment in hong kong (lee et al., 2005), which means that most of the sufferers are undiagnosed and untreated. one of the most effective treatments for sad is cognitive behavioral therapy (cbt), and internet-based cbt has shown promise in reducing general and social anxieties, as well as improving the quality of life of those with sad (e.g. carlbring et al., 2007; tillfors et al., 2011). however, few studies have been conducted in this field in hong kong. this project aims to develop an online cbt program (including both an online platform and mobile application) for hong kong people with sad, as well as evaluate its effectiveness in reducing anxiety symptoms and psychological distress, and improving quality of life at post-treatment and 3- and 6-month follow-ups. randomized controlled trial (rct) design was adopted for program evaluation.

Eligibility criteria:
inclusion criteria: * hong kong residents with fluency in cantonese * between the ages of 18 and 70 * a score of 25 or more on the chinese version of the social phobia inventory (c-spin) (tsai et al., 2009) * have not received any psychological treatment at the time of registration for participation in the project * have access to a computer or smartphone with internet connection. exclusion criteria: * being severely depressed, with a score above 30 on the beck depression inventory-ii (bdi-ii) (beck, steer \& brown, 1996) * having suicidal ideation in the past three months, with a score of 3 points on item 9 of the bdi-ii.
study of foam sclerotherapy versus ambulatory phlebectomy

Conditions: Varicose Veins

Summary: this study will be comparing the treatment of varicose vein tributaries using either foam sclerotherapy or ambulatory phlebectomies. patients will be randomised to having either ambulatory phlebectomy (group a) or foam sclerotherapy (group b) following treatment of their saphenous vein. the re-intervention rates, safety, patient experience as well as the cost effectiveness of each intervention will be assessed.


Eligibility criteria:
inclusion criteria: * adults over 18 years of age * symptomatic gsv or ssv vein reflux \> 0.5 seconds on colour duplex * varicose vein tributary requiring treatment exclusion criteria: * current dvt * recurrent varicose veins * arterial disease (abpi\<0.8) * vein diameter \< 3mm * preference for one of the treatment options * patient who are unwilling to participate * inability or unwillingness to complete questionnaires * inability to attend follow-up appointments * patient currently included in a study of varicose vein treatment