Kornimate/medical-research-clean huggingface dataset:
evolution of the therapeutic care in ovarian cancer from 2011

Conditions: Ovarian Cancer

Summary: the esme ovarian cancer database is a multi-center real life database using a retrospective data collection process in 18 french comprehensive cancer center (fccc) over 20 sites). this database compiles data from existing data available from patient's electronic medical records (emr).

this database compiles data from existing data available from patient's electronic medical records (emr) and integrates data from non-structured ans structured sources. the database includes data related to patient demographics, tumor characteristics (diagnosis, histology, relapses, metastatic disease, etc.), treatments (dates, inn, route of administration, treatment protocols, reason for termination, etc.), and clinical events. data is collected at each participating site by technicians who are specifically trained for the project using an electronic data collection (edc) tool. data imported into the final database are controlled, recoded, and harmonized before import according to the data management plan. all coding procedures are predefined by the data manager. there is no transmission of individual data; all data are centralized within each center using a shared anonymous format. all data is exclusively obtained retrospectively; no attempts are made to recover non available data from the patient's medical record by contacting healthcare providers or patients. esme oc database aims to be a clinical and therapeutic database centralizing existing and available data from different sources used in the participating hospitals. data do not contain any personal data on patients. in compliance with the authorization delivered by the french data protection agency to unicancer, only aggregated statistical reports and publication are released.

Eligibility criteria:
inclusion criteria : * 18 years old female * female who received surgery, chemotherapy, targeted therapy, immunotherapy, radiation therapy, diagnostic procedure, other specific therapeutic procedure) for ovarian cancer in a french comprehensive cancer center. exclusion criteria : none

Keywords: ovarian cancer observational study survival real world data real life setting
trauma expectation factor trauma outcome measure

Conditions: Ankle Fracture; Pilon Fracture

Summary: this study is designed as a prediction trial. that is, our primary purpose is to develop a model that can be applied clinically as a user-friendly "baseline" questionnaire that is capable of predicting "success" or "failure" based on a patient's pre-surgical expectations of their final outcome. in the process, a secondary goal is to develop an outcomes measure.

aims: 1. to develop a novel, psychometrically sound, trauma patient expectation instrument that: a) demonstrates content validity; b) considers patient and surgeon expectations; c) predicts orthopedic outcomes; d) is reliable; e) is patient friendly; and f) is easy to score and interpret. this will be known as the trauma expectation factor (tef). 2. to develop a novel, psychometrically sound, trauma patient outcomes instrument that: a) demonstrates content validity; b) measures current condition in the same domains as the expectation instrument; c) demonstrates construct validity; d) demonstrates criterion validity; e) is reliable; f) is patient friendly; and g) is easy to score and interpret. this will be known as the trauma outcomes measure (tom). hypotheses: h#1. a simple pre-surgical questionnaire that measures patient expectations (i.e., trauma expectation factor) after an ankle fracture requiring surgery will predict an "expected" score on a standardized disease-specific ankle instrument (i.e., aaos foot and ankle core score). h#2. a similar instrument that is reworded to assess current condition (i.e., trauma outcomes measure) instead of expectations, is a valid, reliable, and responsive measure of a traumatic patient's condition. h#3. patient and surgeon expectations of final outcome status are different; however, the differences get smaller over time.

Eligibility criteria:
inclusion criteria: * isolated ankle or distal tibia fracture * scheduled for and undergoing surgery for their fracture * 18 years of age or older exclusion criteria: * subject has previously undergone internal fixation surgery for this ankle fracture * subject has disease entity, or condition that precludes likelihood of bony union (eg, metastatic cancer, metabolic bone disease) * subject has severe dementia or other severe mental health problem that may preclude him/her from completing study questionnaires * subject is participating in other competing clinical research that may interfere with participation in this research * subject is unlikely to attend study related follow-up visits * subject has polytrauma (more than one organ system compromised) * subject has fracture(s) other than ankle fracture * subject is a prisoner * fracture occurred more than 4 weeks ago
automated and personalized cognitive behavioral therapy

Conditions: Depressive Symptoms

Summary: this study is designed to evaluate a novel online tool to deliver computerized cognitive behavioral therapy (cbt). participants will be randomized into three groups: experimental, active control, and waitlist. participants in the experimental group will have access to the full-featured online tool designed to deliver cbt in an interactive and personalized manner. the participants in the active control group will have access to a limited version of the online tool designed to deliver basic cbt in plain text format. the waitlisted participants will be put on a waitlist for 6 weeks. we hypothesize that the experimental group participants will show a significantly higher reduction in depression symptom severity and will show increased engagement and adherence to the online tool.

depression is a major psychiatric disorder globally, including in india. one of the most effective approaches to treat depression is cognitive behavioral therapy (cbt), but its reach is limited by the dearth of trained psychiatrists, especially in remote areas, and the high costs and stigma associated with visits to a psychiatric clinic. delivering cbt through a computer, with limited or no intervention from a psychiatrist, could address these limitations. computerized cognitive behavioral therapy (ccbt) is thus emerging as a more accessible and economical alternative to cbt. despite some evidence of its efficacy, ccbt use is limited because the existing software programs used to deliver the therapy provide a much lower level of personalization and engagement than in-person therapy. the objective of this study is to assess if the new algorithm makes ccbt more efficacious, acceptable and engaging to users. depression severity as measured by the patient health questionnaire-9 (phq-9) is expected to reduce over the duration of the study, more significantly in the treatment group compared to the control group. participants will be recruited online through a website that will check compatibility with inclusion/exclusion criteria and get the informed consent.

Eligibility criteria:
inclusion criteria: * fluent in english * phq-9 score from 5 to 19 * access to internet-connected computer or tablet device * country: india exclusion criteria: * suicide ideation (score greater than 0 on the 9th question of phq-9) * unemployed * current or previous diagnosis of bipolar disorder/manic-depressive disorder or psychosis * prospective participants who say they only want to check out the program and do not plan to complete it are excluded.

Keywords: depression anxiety cbt psychotherapy e-health ccbt
surefire institutional deb-tace

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is to determine the feasibility and safety of the surefire infusion system (sis) for delivery of drug eluting beads transcatheter chemoembolization (deb-tace) in the hcc population. this study will allow us to determine the effectiveness of sis for hcc in terms of disease response.

this is a single arm pilot study to evaluate the technical feasibility and safety of performing deb-tace using the investigational delivery device: surefire infusion system (sis). patients presenting with primary liver cancer without evidence of metastatic disease or vascular invasion will be considered for the trial. patients enrolled in the trial will undergo 1 or 2 sessions of deb-tace delivered through sis as determined by the performing interventional radiologist. decision for second treatment will be based on the degree of disease burden and vascular anatomy demonstrated on the first treatment session. to limit potential hepatotoxicity, patients with multifocal disease in a single lobe may be treated with a 2nd treatment with the investigational device. patients with a large lesion being supplied by multiple vessels may also undergo a 2nd treatment session based on the investigator's judgement. the decision to proceed with a second treatment will be determined at the time of the first treatment based on disease burden and vascular anatomy. there will be an interval of 2-4 weeks between treatments. all patients undergoing 2nd treatment will have a repeat laboratory evaluation with treatment deferred for 2-4 weeks for those not meeting initial inclusion criteria. for patients who labs have not normalized at this time will not undergo a 2nd treatment.

Eligibility criteria:
inclusion criteria: 1. primary liver cancers based on biopsy or imaging criteria 2. child-pugh a or b7 liver disease 3. bilirubin \<2.0 mg/dl 4. albumin \>3.0 gm/dl 5. ecog status 0 or 1 6. adequate renal function a. creatinine \< 2.0 mg/dl 7. age 18 or older 8. able to understand informed consent 9. life expectancy \> 3 months 10. women of childbearing potential must have a negative serum/urine pregnancy test on the day of planned procedure. exclusion criteria: 1. portal vein thrombus 2. uncontrolled ascites 3. hepatic encephalopathy 4. uncorrectable coagulopathy (platelets \ 1.50) 5. untreatable contrast allergy 6. pregnancy 7. symptomatic congestive heart failure 8. prior systematic therapy for hcc
dietary intervention for cardiovascular disease

Conditions: Cardiovascular Diseases

Summary: incidence of cardiometabolic disease (cmd) continues to rise, which consumes huge medical resources in taiwan. the effectiveness of dietary therapy for cmd has not been locally evaluated in detail. cvd is an important risk factor for dementia. at the present time, there is no effective treatment available for dementia. early prevention is extremely important. our previous studies have shown that taiwanese dementia protective diet is very similar to cardiovascular prevention and control diet, meaning that effective dietary therapy may not only control cvd but also prevent dementia development. therefore, this study intends to document the effects of dietary intervention on cardiovascular disease risk factor control, the long-term outcomes on the occurrence of cardiovascular events, and the maintenance of cognitive function for patients with coronary artery disease.


Eligibility criteria:
inclusion criteria: 1. have received percutaneous transluminal coronary artery surgery. 2. stable drug control for more than one month exclusion criteria: 1. suffer from cancer and undergo chemotherapy or surgery within one year. 2. those who have a major illness in hospital within one year. 3. those with kidney disease stage 5 (inclusive) or above 4. those whose life expectancy does not exceed half a year 5. patients with diagnosed dementia 6. those who do not want to be tracked
beta study: improving balance function in elderly by progressive and specific training and physical activity

Conditions: Elderly; Parkinsons Disease; Osteoporosis

Summary: balance control, physical activity and health related quality of life will be assessed before and after a 10 to 12 weeks training program as well as 6 and 12 months thereafter in 200 elderly (\>60) with balance problems (100 with osteoporosis, 100 with parkinson's disease). osteoporosis subjects will be assigned to 3 groups (balance training, balance training and nordic walking, or control group) and parkinson's subjects to 2 groups (balance training or a control group). the training will be progressive and specific incorporating dual task exercises (directly related to an increased risk of falling). clinical and laboratory gait and balance measures as well as questionnaires will be used to assess physical function and quality of life. an earlier study, investigating this training program in healthy elderly with balance problems showed that the training was well-tolerated and effective, with a significant increase in balance control, physical function and activity. in this study, we expect that an improvement in balance function, physical activity and health related quality of life, which will lead to a decreased number of falls, prevent and/or postpone incidence of a hazardous fall and thereby reduce the burden on the health care system. our model for functional balance training and outcome methods will expand techniques and tools available to physical therapists and health care scientist treating and evaluating patients with loss of balance function. elderly receiving therapy with the goal to improve or recuperate physical function and balance will benefit from this project.


Eligibility criteria:
* osteoporosis: to be included the candidate must: be \>65 years with osteoporosis objectively verified by dual energy x-ray absorptiometry (dxa) in the hip and lumbar back,be an independent ambulator, have experienced at least one fall in the last 12 months and have an adequate medical treatment for their osteoporosis. * parkinson's disease: all pd subjects will have a clinical diagnosis of -idiopathic‖ pd (hoehn \&yahr scores 2-3), \> 60 years of age and no other existing neuromuscular disorders, including severely flexed posture. in addition, the subjects will have no history suggesting -atypical‖ pd symptoms. exclusion criteria's for all subjects are: * moderate-severe dementia (mini-mental score \<24) * respiratory, cardiovascular, musculoskeletal or neurological (except pd) disorders that may interfere with participation in the exercise program

Keywords: balance gait physical activity
study on the application of hyperspectral imaging technique in ctx treatment of imn

Conditions: Hyperspectral Imaging; Idiopathic Membranous Nephropathy; Cyclophosphamide

Summary: investigators propose hyperspectral imaging analysis as a method to distinguish the efficacy of hormone-combined cyclophosphamide therapy for pmn, and classify sensitive and insensitive patients treated with hormone-combined cyclophosphamide regimen. a variety of machine learning models were used to prove that hyperspectral imaging technology could assist patients in selecting the optimal treatment plan, and further explore the predictive indicators of pmn treatment effect.

renal puncture pathological sections from patients with nephropathy. envi classic software was used to process the hyperspectral images and delineate the region of interest, and the one-dimensional spectral data of each pixel in each region were derived. machine learning and deep learning methods were used to analyze the characteristics of hyperspectral data and classify them. the data of the previous study came from the department of pathology and nephrology of qianfoshan hospital in shandong province. under the light microscope, electron microscope and immunofluorescence microscope, the pathological types of glomerular diseases in patients with proteinuria were identified. by scanning the corresponding patient's h\&e stained pathological sections, the hyperspectral microscopic images were classified by machine learning and deep learning methods, and the classification accuracy was greater than 85%. it was concluded that hyperspectral imaging technology can be used as a non-invasive diagnostic method to predict treatment response.

Eligibility criteria:
inclusion criteria: * over 18 years old; * patients with idiopathic membranous nephropathy confirmed by renal biopsy; * had not received hormone and/or immunosuppressive therapy before renal biopsy; * complete clinical data, all signed the "admission certificate of qianfoshan hospital of shandong province", and agreed to use relevant medical information, biological specimen examination and examination results for scientific research. exclusion criteria: * 1.there are factors causing secondary membranous nephropathy, such as immune diseases (systemic lupus erythematosus), tumors/infections (viral hepatitis), drugs or poisons, etc. ; * severe infection: fever, cough and expectoration, sore throat, abdominal pain, diarrhea, carbuncle and furuncle and other clinical manifestations of skin and soft tissue infection, blood routine white blood cell count beyond the normal range (10×109/l); * severe cardiovascular disease: including chronic heart failure grade 3 or above and various arrhythmias; * infectious diseases: active hepatitis, aids, syphilis, etc. ; * tumor evidence: it has been found that there is a certain tumor or clinical manifestations, tumor markers, etc., suggesting the possibility of tumor; * patients with follow-up time less than 6 months, incomplete data or missed diagnosis;
video-assisted training in the intensive care process focuses on the intensive care experiences of patients who will undergo open heart surgery and effect on anxiety levels

Conditions: Open Heart Surgery

Summary: the study will consist of experimental and control groups. patients in the experimental group will be administered the patient introduction form, intensive care experience scale and state anxiety scales before surgery. then, video-supported training will be given about the intensive care process, and the state anxiety scale and intensive care experience scales will be re-administered to the patients 24 hours after the surgery. these scales will be administered to the patients in the control group without video-supported training. no intervention other than standard nursing care will be given to patients.

the study will consist of experimental and control groups. patients in the experimental group will be administered the patient introduction form, intensive care experience scale and state anxiety scales before surgery. then, video-supported training will be given about the intensive care process, and the state anxiety scale and intensive care experience scales will be re-administered to the patients 24 hours after the surgery. these scales will be administered to the patients in the control group without video-supported training. no intervention other than standard nursing care will be given to patients. the study will have a sample size of 62: 31 experimental and 31 control groups.

Eligibility criteria:
inclusion criteria: * those between the ages of 18-75, * those who agree to participate in the research and volunteer, * no communication problems, * cognitive level scales are suitable for application, * patients without vision and hearing problems were included in the study. exclusion criteria: * leaving work voluntarily, * patients whose cognitive level scales were not suitable for application were excluded from the study.

Keywords: bypass open heart sungery
efficacy of vitamin a in fortified extruded rice in school children

Conditions: Vitamin A Deficiency

Summary: the project aims to evaluate the potential impact triple fortified rice grains, mixed into natural rice grains, can have on vitamin a status if fed to school children in southern thailand. within a 60 day intervention study, changes in vitamin a status in young children fed the fortified rice compared to children consuming non-fortified rice will be assessed.

iron, zinc and vitamin a deficiencies are particularly common among children and young women in developing countries of south and southeast asia. rice is a common staple for a large part of these sub-regions of asia. in spite of a wide range of rice varieties eaten, rice is eaten by all age groups and is one of the first few foods used as complementary food for infants. fe fortification of rice using a method of heat extrusion and micronized ferric pyrophosphate (fepp) as iron fortificant has shown to be efficacious in increasing iron stores and reducing the prevalence of iron deficiency in indian school children. subsequent extrusion trials have shown promising results with respect to color and vitamin a (va) stability when rice grains were triple fortified with fe, zn and vitamin a. preliminary data in the region of satun, south thailand, have shown that zinc and vitamin a intakes are low. biochemical indicators have confirmed zinc deficiency and suboptimal vitamin a status in 1/3 of school aged children. since rice is the main staple food in this area, rice triple fortified with fe, va and zn is a promising strategy to combat micronutrient deficiencies in children. the aim of this study is to demonstrate whether triple fortified rice has an impact on vitamin a status of children. the study will be conducted in school children (8 to 12 years old). the children will be randomized to either receive a daily lunch rice meal prepared from fortified rice (the triple fortified rice grains will be mixed into natural rice at a ratio of 1:50) or from non-fortified rice for 60 days. as serum retinol concentration, the most widely used indicator for the assessment of vitamin a status, is not a very reliable indicator due to homeostatic control and the influence of infection, we will in addition use the tracer methodology using dilution of stable isotopes with which total body vitamin a pool size will be estimated prior to the intervention and after 60 days of the intervention..

Eligibility criteria:
inclusion criteria: * children, aged 8-12 years, both sexes, attending the local primary schools * no known or reported history of significant chronic illness * free of acute illness and febrile and gastrointestinal problems exclusion criteria: * children with severe vitamin a deficiency with a clinical sign of bioit's spot or ocular signs of xerophthalmia will be excluded * children who have serum retinol \< 0.7 umol/l

Keywords: vitamin a deficiency
effect of genetic and epigenetic factors on the clinical response and toxicity to cisplatin among egyptian non-small cell lung cancer patients

Conditions: Non Small Cell Lung Cancer; Nephropathy; Cardiotoxicity

Summary: lung cancer is the leading cause of death worldwide, with non-small-cell lung cancer (nsclc) being the most common histotype according to the global cancer observatory 2022. a variety of therapeutic options for advanced/metastatic non-oncogene-addicted nsclc have recently been approved based on their impact on patient outcomes in terms of survival and safety profile. current guidelines advocate for personalized treatment options based on molecular and immunologic characteristics, which drives the physician's decision toward tailored oncology. in the last two to three decades, hundreds of cancer biological prognostic markers for non-small cell lung cancer have been proposed. although they have shown a potential in this ﬁeld, validation studies are still required and, to date, there is in suﬃcient evidence to recommend the routine clinical use of any of these putative biomarkers. therefore, the discovery of robust prognostic and/or predictive biomarkers in patients with non-small cell lung cancer is imperative for advancing treatment strategies for the disease and improving patient care.


Eligibility criteria:
inclusion criteria: * nsclc cancer patients treated with cisplatin-containing chemotherapy. * measurable disease. * age of 18 years to 80 years. exclusion criteria: * non-small cell lung cancer patients who had undergone radiotherapy or chemotherapy. * pregnant and lactating females. * history of allergic reactions attributed to compounds of similar chemical or biologic composition to oxaliplatin. * any other medical or psychiatric condition or severe or chronic laboratory abnormality making the inclusion of the patient in the study inappropriate in the opinion of the investigator.

Keywords: non-small cell lung cancer nephropathy cardiotoxicity gene polymorphism cisplatin