Kornimate/medical-research-clean huggingface dataset:
postprandial vldl-tg metabolism

Conditions: Type 2 Diabetes

Summary: in thise study, we aim to determine the effect of meal fat on vldl-tg kinetics in type 2 diabetic and healthy subjects matched for bmi in order to elucidate the potential pathophysiological differences in vldl-tg fa channeling towards oxidation and storage in abdominal and leg subcutaneous adipose tissue. specifically, we want to measure, by way of fat and muscle biopsies, the quantitative postprandial storage of vldl-tg fa's in skeletal muscle and adipose tissue in relation to a series of tissue specific proteins and enzymes that might be involved in regulating skeletal muscle and adipose tissue fa storage.


Eligibility criteria:
inclusion criteria: * written consent exclusion criteria: * known diseases * alcohol abuse * smoker * regular use of medicine

Keywords: vldl-tg kinetics postprandial state obesity
neural mechanisms of decision making in hoarding disorder

Conditions: Hoarding Disorder

Summary: the purpose of this study is to understand the neural mechanisms of decision making in hoarding disorder.

hoarding disorder is a common and disabling disorder that represents a significant public health problem. this study aims to build on current research on decision making by examining these processes in hoarding disorder.

Eligibility criteria:
identify inclusion criteria. inclusion criteria for participants diagnosed with hd: 1. ages 18-70 2. primary diagnosis of hoarding disorder 3. sufficient severity of hoarding symptoms 4. stable on psychotropic medications for 1 month prior to study enrollment 5. capacity to provide informed consent 6. ability to tolerate clinical study procedures inclusion criteria for healthy control participants: 1. ages 18-70 2. capacity to provide informed consent identify exclusion criteria. exclusion criteria for participants with hd: 1. psychiatric or medical conditions that make participation unsafe 2. pregnant or nursing females 3. concurrent use of any medications that might increase the risk of participation (e.g. drug interactions) 4. presence of metallic device or dental braces exclusion criteria for healthy control participants: 1. any current or lifetime psychiatric diagnosis 2. current or past use of psychotropic medication 3. pregnant or nursing females 4. major medical or neurological problem 5. presence of metallic device or dental braces

Keywords: hoarding disorder
adaptive dance exercise program on trunk control, balance and functional mobility in cerebral palsy

Conditions: Cerebral Palsy

Summary: the human body needs a system to control and coordinate its action plan in order to perform an effective action. this system works irregularly or inappropriately in people with cerebral palsy (cp). an alternative to controlling these disorders is automatic movement modulation such as dance. dance, whose main purpose is to achieve a satisfying motor performance, increases motor learning with sensory, perceptual and emotional components. although the effects of dance therapy on functionality, balance and participation in people with cp have been previously examined in the literature, it has been reported that the evidence is insufficient and more studies are needed. the aim of this study is to examine the effects of adaptive dance exercise program on trunk control, balance and functional mobility in children and adolescents with cerebral palsy.


Eligibility criteria:
inclusion criteria: * diagnosed with cerebral palsy * volunteer * ages between of 6-18 years * gross motor function classification system (gmfcs) level 1 and level 2 * to have cognitive skills to understand and apply adaptive dance exercises to be given. exclusion criteria: * participants diagnosed with cerebral palsy having cognitive disorders * participants diagnosed with cerebral palsy having vision or hearing problems * participants diagnosed with cerebral palsy have a history of trauma such as botox or muscle relaxation operation and / or fracture at least 6 months before participating in the study.

Keywords: cerebral palsy trunk control mobility adaptive dance balance
transversus abdominis plane blocks for patients undergoing robotic gynecologic oncology surgery

Conditions: Gynecologic Cancer; Post-operative Pain

Summary: this study is a single-center, randomized, placebo-controlled, double-blind clinical trial. the purpose of this study is to evaluate the impact of pre-operative transverses abdominis plane (tap) blocks on post-operative analgesia in patients undergoing robotic surgery for gynecologic cancers.


Eligibility criteria:
inclusion criteria: * patients undergoing robotic-assisted surgery under the care of the division of gynecologic oncology at uwhc. * patients must be ≥18 years old. * patients must be english speaking. * patients must have the ability to understand visual and verbal pain scales. * asa physical status 1-3. exclusion criteria: * known allergy to local anesthetics. * immunocompromised. * known history of opioid dependence, as available within the medical record and standard of care pre-operative work-up. * known history of chronic pain disorders. * pregnancy or lactation. * patient is a prisoner or incarcerated. * significant liver disease that would inhibit prescription of opioids.

Keywords: pain control gynecologic oncology surgery
severe renal disease study in fabry patients treated with fabrazyme

Conditions: Fabry Disease; Chronic Kidney Disease, Stage IV (Severe)

Summary: this study was designed to determine appropriate treatment with fabrazyme at a biweekly dose of either 1 mg/kg or 3 mg/kg in a population of patients with severe renal disease burden.


Eligibility criteria:
inclusion criteria: * provided written informed consent prior to any study-related procedures being performed. * be ≥16 years old. * have a current diagnosis of fabry disease (defined as abnormal α-galactosidase (α gal) enzyme levels or fabry genotype). * have one of the following clinical conditions present at enrollment: serum creatinine level greater than 3.0 mg/dl (an average of two values at least one week apart), or be currently on dialysis, or be status post kidney transplant by greater than 3 months. * have the ability to comply with the requirements of the protocol * have a negative pregnancy test, if a female patient of childbearing potential. in addition, all female patients of childbearing potential must use a medically accepted method of contraception throughout the study. exclusion criteria: * if they did not meet the specific inclusion criteria. * if they had participated in a study employing an investigational drug within 30 days of the start of their participation in this trial. * had previously received enzyme replacement therapy (ert) for their fabry disease. * had diabetic nephropathy. * were pregnant or lactating. * were unwilling to comply with the requirements of the protocol.

Keywords: fabry disease patients with severe renal disease
complementary acupuncture treatment of dysphagia in stroke

Conditions: Stroke

Summary: a taiwanese study pointed out that stroke patients who have language barriers, dysphagia, and aspiration pneumonia are more likely to suffer from prolonged hospitalization. improvements in dysphagia and subsequent complications in patients should be effective in reducing hospital stays and improving the quality of long-term care. in view of clinical medical needs and policy trends, this study aims to explore the efficacy of using traditional chinese medicine to treat cerebral apoplexy sequelae in taiwan. it is expected that through (1) exploration of real-world data analysis, combined with the advantages of taiwan's biomedical database, data exploration will be carried out to provide big data (2) multi-center prospective randomized clinical trials, providing clinical evidence of the highest level of evidence in empirical medicine.


Eligibility criteria:
inclusion criteria: * .patients aged more than 20 years * the diagnosis of first stroke was established within the six months * patients had a score ≥ 25 of mini-mental state examination (mmse) * patients met one or both indications as follows 1. dysphagia confirmed under the standardized swallowing assessment 2. nasogastric tube feeding already exclusion criteria: * previous history of swallowing disability * currently known coagulopathy leading to bleeding disorder. * previous surgery of head or neck * local infection at or near the acupuncture site is not suitable for acupuncture after physician examination. * psychological or behavior disorder * currently pregnant or breastfeeding women. * previous acupuncture treatment for any indication within 30 days of enrollment. * severe chronic or uncontrollable complications interference the processing of the trial

Keywords: acupuncture swallowing impairment
sildenafil citrate for treatment of growth-restricted fetuses

Conditions: Fetal Growth Restriction

Summary: the aim of this study is to assess the effect of sildenafil citrate therapy on neonatal outcomes in women with fetal growth restriction.


Eligibility criteria:
inclusion criteria: * maternal age ranging from 20-40 years. * gestational age 28-37 weeks. exclusion criteria: * obese patients (bmi \>30 kg/m2). * patients with medical disorders: cardiac diseases, pulmonary diseases, liver disease, renal disease, previous history of seizures, hearing loss. * drug interactions, such as users of any vasodilator agents, omeprazole, clarithromycin and amoxicillin. * fetal distress. * pregnancy of multiple fetuses. * congenital fetal malformation or chromosomal abnormalities. * diastolic blood pressure more than 110 mmhg. * hypersensitivity to the drug.
patient-specific versus conventional instrumentation in tka

Conditions: Osteoarthritis, Knee

Summary: the aim of this prospective multicenter randomized clinical trial (rct) is to compare the clinical and radiologic results of primary total knee arthroplasty (tka) using patient-specific versus conventional instrumentation.


Eligibility criteria:
inclusion criteria: * patients with primary or secondary osteoarthritis of the knee requiring total knee arthroplasty * aged between 18 and 85 years * able to understand information * affiliated to social security. exclusion criteria: * active or suspected sepsis * tumor around the knee * previous partial or total knee replacement * presence of hardware that could artifact mri * contraindication to mri * extra-articular deformation requiring osteotomy around the knee in conjunction with tka * social situation that could impair follow-up.
the kp personal shopper: a pilot to improve the impact of dietary advice

Conditions: Overweight; Obesity

Summary: randomized trial of grocery-store based nutrition counseling visits for weight management vs. in-office visits. the investigators will test pre- and post-intervention individual-level dietary quality, knowledge, self-efficacy around dietary choice, and cost of shopping, measuring difference between intervention and control arms. at the study's end, the investigators will also conduct focus groups with a subset of 20 patients (10 from each arm) and do a structured interview with the dietitian to better understand the feasibility, strengths and shortcomings of this approach. patients who complete the main portion of the trial will be randomly selected for recruitment into a focus group and consented separately for that focus group at the end of the study. the investigators hypothesize that, compared to office-based visits, the kp personal shopper visits will result in higher member diet quality scores, better nutritional knowledge scores, higher self-efficacy and confidence around food purchasing decisions, and more favorable perception of the visit by both dietician and member. the kp personal shopper approach may also result in increased grocery store costs for some members. long-term, the investigators hypothesize that improvements in member perception, knowledge and dietary quality will lead to improved health outcomes.


Eligibility criteria:
inclusion criteria: * employee population of a specific southeastern u.s. county * 18-64 years of age * body mass index greater than or equal to 30kg/m\^2 (obese) * low rate of no-shows for office visits (\<10%) * saw pcp or other provider in past 12 months * does at least 50% of the food shopping and/or food preparation for their household exclusion criteria: * non-english speaking * currently being treated for cancer (other than non-melanoma skin cancer) * pregnant or planning pregnancy in the next 6 months * had or considering having bariatric surgery * currently participating in commercial weight loss program (e.g. jenny craig) * currently enrolled in another weight management or nutrition study

Keywords: dietary advice nutritional knowledge self-efficacy nutrition
the effect of exergame games on geriatric individuals with kinesiophobia

Conditions: Geriatric; Kinesiophobia

Summary: the study included 15 geriatric individuals over the age of 65 staying in kızılay zeynep nedim oyvar nursing home and elderly nursing home. participants in the study were rehabilitated by playing exergame games with xbox 360 kinecttm for 30 minutes once a week for 8 weeks. before starting the application, the participants were given a demographic information form, tampa kinesiophobia scale for kinesiophobia, nintendo wii balance platform and basic balance game for balance measurement, geriatric depression scale-short form for depression, cognitive functions, and mini-mental state test for the lower extremities. functional strength and risk of falling. the shuttle test was applied 5 times. these tests will be repeated at the end of 8 sessions and before and after values were measured. as a result of the analysis, the effects of xbox 360 kinecttm games on kinesiophobia, balance, lower extremity muscle strength, depression, and cognitive functions in geriatric individuals with kinesiophobia were investigated.

15 geriatric individuals over 65 years old living in kızılay zeynep nedim oyvar nursing home and elderly care center were included in the study. the ethics committee of istanbul gedik university ethics committee, dated 17/01/2023 and numbered e-56365223-050.01.04-2023.137548.27-433, was accepted. a consent form was signed by geriatric individuals who met the conditions of this study. participants participating in the study played 30 minutes of exergame games once a week for 8 weeks and rehabilitation was applied. before starting the application, participants were given a demographic information form, tampa kinesiophobia scale for kinesiophobia, becure balance assessment system for balance measurement, geriatric depression scale-short form for depression, mini-mental state test for cognitive functions, and lower extremity functional strength and risk of falling 5 times. lift test was applied. these tests were repeated at the end of 8 sessions and before and after values were measured.

Eligibility criteria:
inclusion criteria: * getting 38 or higher on the tampa kinesiophobia scale * getting a mini mental state test score of 20 and above * being physically competent to apply the scales to be used * being 65 years or older * volunteering to work exclusion criteria: * having a mental and psychiatric problem diagnosed by a physician * having a serious neurological and orthopedic problem diagnosed by a physician * having serious hearing and vision problems * having uncontrolled diabetes and hypertension * using a walking device other than a cane (crutches, walkers, etc.) * drug use that increases the risk of falling (to be determined by the information obtained from nurses and physiotherapists working in nursing homes)

Keywords: geriatrics kinesiophobia virtual reality video based game xbox 360 kinecttm
cone-beam ct guided microcoil localization of pulmonary nodules during video assisted thoracic surgery(vats)

Conditions: Lung Cancer

Summary: the guided therapeutics (gtx) program at the university health network is a network of clinicians, scientists, and engineers focused on the development and translation of image-guided technologies focused on minimally-invasive, adaptive therapies. technologies developed within the gtx program include a portable intra-operative cone-beam ct (in collaboration with siemens) that has been evaluated in clinical trials for head and neck surgery. the intraoperative imaging has been integrated with tracking and navigational tools and optical imaging to provide a general "surgical dashboard" that is used to improve the accuracy of surgical resection. a recent addition to the gtx program is the development of the gtx or, located within the general operating room of the toronto general hospital. the gtx or houses 2 complimentary advance technologies: the siemens zeego and the siemens somotom flash ct. the dual-energy somatom flash provides a "gold-standard" in ct imaging, while the zeego provides excellent 3d cone-beam ct with robotic placement for flexible integration within the operating environment. together, the integration of these 2 components into a single or enables critical evaluation of the limits of ct imaging technology for surgical guidance. this study will be conducted using solely the cone-beam ct (zeego) for percutaneous placement and localization of markers for resection of small pulmonary nodules during vats.


Eligibility criteria:
inclusion criteria: * any adult patient age 18 and older with lung nodules who are candidates for microcoil localization prior to vats wedge resection exclusion criteria: * patients that are unable to give informed consent * patients that are unable to tolerate general anesthesia * patients who are pregnant or patients that believe they are pregnant * patients with implantable devices susceptible to radio frequency (rf) fields * severely obese patients
spinal cord injury registry - north american clinical trials network

Conditions: Spinal Cord Injury

Summary: the nactn spinal cord injury registry is a network of clinical centers collecting de-identified data from patients admitted through the emergency department of a nactn center at the time of injury with an initial (first time) spinal cord injury (sci). information will be collected on the natural history of sci and course of treatment through the first 12 months from the date of injury or long as medically indicated. data collected includes imaging information from ct or mri scans, neurological and general medical outcome and rehabilitation evaluation. no intervention is given other than standard of care for spinal cord injury, intensive monitoring and frequent follow up care.

the participating centers include: university of texas health science center, houston; university of toronto, toronto; university of virginia, charlottesville; university of louisville, louisville; university of maryland, baltimore; walter reed national military medical center, bethesda; thomas jefferson university, philadelphia; university of miami, miami; brooke army medical center, fort sam houston; louisiana state university health sciences center, new orleans; vanderbilt university medical center, nashville; medical college wisconsin, milwaukee; duke university, durham the nactn clinical coordinating center is located at: houston methodist hospital, houston the center for biostatistics is located at: houston methodist hospital, houston the data management center is located at: university of louisville, louisville preliminary work has been completed on the selection of data elements, data collection protocols, case record form design, and the design of a computer system for clinical data management and data quality control. in the first phase of the network, data will be collected on the natural history of sci. although there is considerable data in the literature about the natural history of sci, current changes in treatment appear to be modifying the natural history. in particular very early surgery, including decompression of the spinal cord and vertebral stabilization with instrumentation appears, in some cases of sci, to be improving outcomes. no treatment is given other than standard of care for sci. data is collected in hopes to help sci patients in the future.

Eligibility criteria:
inclusion criteria: * any patient male or female \> or equal to 18 years of age with first time spinal cord injury caused by trauma and has neurological deficit with paralysis (weakness) or loss of sensation (touch). * has not received prior medical of surgical care for this injury at an intermediate hospital. * must give informed consent exclusion criteria: * any patient or family refusing consent

Keywords: spinal cord injury sci traumatic spinal cord injury acute spinal cord injury paralysis
usability and tolerability of the norditropin nordiflex® injection device in children never previously treated with growth hormone

Conditions: Growth Hormone Disorder; Growth Hormone Deficiency in Children; Genetic Disorder; Turner Syndrome; Foetal Growth Problem; Small for Gestational Age; Chronic Kidney Disease; Chronic Renal Insufficiency; Delivery Systems

Summary: this study is conducted in europe. the purpose of this study is to assess the impact on daily life for children new to using a growth hormone injection device.


Eligibility criteria:
inclusion criteria: * growth hormone (gh) treatment naïve subjects for whom it has been decided to initiate gh treatment prior to enrollment into the study * subjects who receive norditropin nordiflex® according to the spc exclusion criteria: * known or suspected allergy to study product(s) or related products * child and/or parent unable to give consent or fill out the questionnaires * the receipt of any investigational medicinal product within 3 months prior to this study * suffer from a life-threatening disease