Kornimate/medical-research-clean huggingface dataset:
type o whole blood and assessment of age during prehospital resuscitation trial

Conditions: Hemorrhagic Shock; Traumatic Injury

Summary: open label, multi-center, pre-hospital randomized trial utilizing 10 level-1 trauma centers designed to determine the efficacy and safety of low titer whole blood resuscitation as compared to standard of care resuscitation in patients at risk of hemorrhagic shock and to appropriately characterize the hemostatic competency of whole blood relative to its age.


Eligibility criteria:
inclusion criteria: 1.) injured patients at risk of hemorrhagic shock being transported from scene or referral hospital to a participating towar trial site that meet requirements for initiation of blood or blood component transfusion and 2a.) systolic blood pressure ≤ 90mmhg and tachycardia (hr ≥ 108) at scene, at outside hospital or during transport or 2b.) systolic blood pressure ≤ 70mmhg at scene, at outside hospital or during transport exclusion criteria: 1. wearing no towar opt-out bracelet 2. age \> 90 or \< 18 years of age 3. isolated fall from standing injury mechanism 4. known prisoner or known pregnancy 5. traumatic arrest with \> 5 minutes of cpr without return of vital signs 6. brain matter exposed or penetrating brain injury (gsw) 7. isolated drowning or hanging victims 8. objection to study voiced by subject or family member at the scene 9. inability to obtain iv or intraosseous access 10. isolated burns without evidence of traumatic injury

Keywords: hemorrhage trauma whole blood
the study of plum-blossom needling enhancing efficacy of aminolevulinic acid-photodynamic therapy for actinic keratosis

Conditions: Actinic Keratoses

Summary: background limited in the depth of absorption and penetration of photosensitizers, ala-pdt treatment is not strong enough for thickening significantly ak lesions. pre-study has proved that plum-blossom needling facilitates delivery of topical ala into the dermis. it could help ala to diffuse a little more broadly in superficial dermis and obtain similar clinical effect with a much lower cost. objective we sought to investigate whether plum-blossom needling (pbn) would enhance the efficacy of ala-pdt for aks. methods two hundred and fifty patients, previously diagnosed as having aks of the face and scalp, were randomized distribution into two groups. the pbn-ala-pdt group underwent vertical skin tapping with pbn before applying 10% ala cream and narrow-band light-emitting diode (led) irradiation (mean 633 nm, with a standard deviation \[sd\] of 10 nm; 100-200 j/cm2). the ala-pdt group received ala cream and irradiation only. during the next 1 year period of follow up, patients were clinically evaluated for new aks.


Eligibility criteria:
inclusion criteria: * (1) clinical diagnosed with ak (olsen classification grade i, ii, iii), aged \> 18 years (because no dosing or adverse event data are currently available on the use of topical aminolevulinic acid in patients \<18 years of age, children are excluded from this study); (2) all patients are unfit and reluctant to undergo surgery for any reasons, and volunteered to participate in the study and ability to understand and the willingness to sign a written informed consent. patents are willing to pay for the treatment, and agreed to take a picture of the skin lesions. exclusion criteria: * (1) those who had ala-pdt and any other studies that affect this study within 12 weeks ; (2) there are other facial diseases that may affect the efficacy evaluation, such as other photodermatosis; (3) take phototoxic or photosensitizer within 8 weeks; (4) clinical and / or pathological prove that the tumor has invaded other organs or tissues; (5) serious immunocompromised persons; (6) scar constitution; (7) patients are known to have skin photosensitivity, porphyria, or allergies to ala, light or lidocaine; (8) persons are suffering from severe internal diseases, mental and mental illness, infectious diseases or pregnant or lactating women.

Keywords: plum-blossom needling photodynamic therapy actinic keratoses
efficacy and safety of light compression system in the local treatment of mixed leg ulcers (promethee clinical investigation)

Conditions: Leg Ulcers

Summary: evaluation of the efficacy (wound epithelialization and time to closure) and safety (emergence and nature of adverse event) of a lite compression system versus a tubular bandage in the local treatment of mixed leg ulcers: prospective multicenter, randomized controlled, open-label french clinical study

this is a prospective, randomized, controlled, open-label, multicenter clinical trial conducted in patients with a mixed (non-ischemic) leg ulcer of stage c6 / c6r of the ceap classification. this study is carried out in around 50 french investigational centers. a total of 210 patients meeting the eligibility criteria will be included. the patients will be followed for 16 weeks and a total of 6 clinical evaluations will be carried out by the investigating centers. a planimetric survey of the studied leg ulcers is carried out during the initial assessment of the wound (day 0) and at each assessment provided for in the protocol (week 2, week 4, week 8 and week 12). a qol is carried out at d0 and end of the study for each patient included in the protocol.

Eligibility criteria:
inclusion criteria: * adult patient (≥ 18 years old), having given free, informed and written consent * patient affiliated to a social security scheme * patient agreeing to wear the study compression system daily * patient with an ankle circumference between 18 and 25 cm * target wound: stage c6 / c6r mixed leg ulcer of the ceap classification with a 0.6≤ abpi≤0.8 and tabp≥ 50 mm hg and arterial echo doppler confirming the mixed nature of the leg ulcer * target wound with an area between 2 and 20 cm2 * target wound with age of ≤18 months criteria exclusion: * patient with a systemic infection not controlled by appropriate antibiotic therapy * patient having presented in the 3 months preceding his inclusion, a deep vein thrombosis * severe arterial pathology, including an ankle blood pressure index (abpi) less than 3 months old \<0.6 * patient bedridden or spending less than an hour per day standing * clinically infected target wound * cancerized target wound

Keywords: mixed leg ulcers quality of life questionnaire light compression system
feasibility and effectiveness of a sleep hygiene education program for sleep issues in breast cancer survivors

Conditions: Breast Cancer; Sleep Hygiene

Summary: the proposed research will assess the feasibility and preliminary effectiveness of a sleep hygiene program for breast cancer survivors. participants will complete assessments related to sleep issues, participate in a sleep hygiene program, and complete another assessment post-intervention.


Eligibility criteria:
inclusion criteria: 1. diagnosed with breast cancer and not currently receiving active treatment in the form of chemotherapy or radiation therapy, 2. at least 18 years of age, 3. women 4. score \> 5 on the pittsburgh sleep quality index 5. participant has a smartphone that operates on the android or apple platform 6. participant is able to use the ecological momentary assessment application in the morning 7. functional english fluency and literacy exclusion criteria: 1. self-reported history of diagnosis of co-morbidities that have been associated with poor sleep and fatigue: chronic insomnia, chronic fatigue syndrome, unstable heart, lung, or neuromuscular disease, insulin-dependent diabetes, sleep apnea, chronic oral steroid therapy, and night-shift employment. 2. currently taking a pharmacological sleep aide

Keywords: breast cancer, sleep, intervention sleep intervention self-management
predictive value of whole blood coagulation parameters for post-discharge venous thromboembolism after cancer resection

Conditions: Venous Thromboembolism

Summary: this study plans to learn more about the role of 2 blood tests in predicting who might develop a blood clot in their arm or leg after major surgery. the investigators know that patients who have cancer and major surgery have a higher than normal risk of getting blood clots in the veins of their arms or legs. this can be very dangerous because the clot can move into your lungs.

venous thromboembolism (vte) after cancer surgery hospitalization is the most common cause of death at 30 days after cancer surgery, and is a significant source of patient morbidity and health care cost. pharmacoprophylaxis has proven efficacy in preventing post-discharge vte in surgical cancer patients, but perceived risks and costs pose barriers to widespread adoption by clinicians. risk stratification of this patient population is necessary to allow appropriate prescription of prophylaxis to the highest risk patients. can the investigators develop a risk stratification model that includes a readily available laboratory test, the thromboelastogram with or without platelet mapping?

Eligibility criteria:
inclusion criteria: * subjects who are having primary, open resection surgery of gastrointestinal or bladder cancer exclusion criteria: * currently receiving anticoagulation therapy * pregnant
post-operative pain evaluation after using different single-file root canal preparation system: a randomized clinical study

Conditions: Root Canal Treatment

Summary: the goal of this clinical trial is to assess post-operative pain following root canal preparation using various single-file systems

the goal of this clinical trial is to assess post-operative pain following root canal preparation using various single-file systems.postoperative pain assessment was done by an independent evaluator with no knowledge of the group under investigation. the visual analogue scale (vas) was employed. patients could put a mark anywhere on the vas sheet with values ranging from 0 to 100 mm \[10\]. * score 0: no pain (between 0 and 4 mm) the tooth after treatment felt normal, and no discomfort was reported by the patients. * score 1: recognizable, mild pain (between 5 and 44 mm), not requiring analgesics. * score 2: moderate pain (between 45 and 74 mm) that is uncomfortable but bearable (when analgesics were taken, the pain was successfully reduced). * score 3: severe pain (between 75 and 100 mm) painful to endure (pain was not relieved by taking analgesics). the patients in this study were not aware of the preparation system used during treatment. following treatment, three readings were taken at 24, 72, and 7 days. each patient carried a vas form, and reminder calls were made to record pain levels and return the form filled out completely

Eligibility criteria:
inclusion criteria: * • teeth with a single root canal with nearly the same apical diameter (#15) * vital pulp exposures due to caries or trauma with asymptomatic pulpitis * restorable teeth exclusion criteria: * • patients with immune deficiencies or systemic illnesses * pregnant women * cases of re-treatment * symptomatic non-vital teeth that require root canal therapy * presence of root resorption * teeth with anatomic variations * a cute periapical abscess cases with pus discharge * a patient who has several teeth that need to be treated in order to eliminate the likelihood of pain referral * periodontal diseases * patients on analgesics, anti-inflammatory drugs, sedatives, or antibiotics seven days before therapy

Keywords: hyflex/edm; post-operative pain; single-file systems; wave one gold; xp-endo shaper.
capflex-pip© motion

Conditions: Finger Joint; Arthroplasty; Replacement; Motion

Summary: the purpose of this study is to describe and to compare the motion analysis parameters, i.e. motion and stability of proximal interphalangeal joints, which were treated with a capflex-pip© implant or silicone implant and to generate basic knowledge about motion analysis of untreated healthy hands.


Eligibility criteria:
inclusion criteria: * patients with proximal interphalangeal joint osteoarthritis in the index or middle finger, treated with a capflex-pip© implant or with a silicone implant and with a follow-up time between 12 and 60 months after primary implantation or * patient with one untreated healthy hand without joint osteoarthritis * patient aged 50 years and over * patient willing and able to give written informed consent to participate in the study exclusion criteria: * inflammatory disease (e.g. rheumatoid arthritis) * pregnant women * german language barrier to complete the questionnaires * any disease process that would preclude accurate evaluation (e.g. neuromuscular, psychiatric or metabolic disorder) * legal incompetence * participation in any other medical device or medicinal product study within the previous months that could influence the results of the present study
pain management in knee osteoarthritis

Conditions: Osteoarthritis; Knee Osteoarthritis; Pain, Chronic

Summary: in this study, it was aimed to investigate the effect of pain management education in individuals with knee osteoarthritis with chronic pain.

knee osteoarthritis (oa), also known as degenerative joint disease of the knee, is typically the result of wear and tear and progressive loss of joint cartilage. knee osteoarthritis can be divided into two types, primary and secondary. it is most common in the elderly. the intensity of clinical symptoms can vary from person to person. however, they typically become more severe, more frequent, and more debilitating over time. the rate of progression also varies with each individual. people suffering from knee osteoarthritis complain of limited range of motion and pain when they move their knee or start walking. in advanced disease, they may complain of nocturnal or persistent knee pain and the functionality of the joint is severely impaired. knee osteoarthritis treatment begins with non-surgical (conservative) treatment methods. non-surgical treatment includes patient education, lifestyle modification, and the use of orthotic devices. it has been shown that untreated pain in the elderly can have a general impact on their quality of life and lead to depression, anxiety, social isolation, cognitive impairment, inactivity, and sleep disorders. the aim of our project is to provide training for patients diagnosed with knee osteoarthritis with chronic pain to be able to control their pain with self-management and to perform activities of daily living more easily. appropriate knowledge and awareness can improve their quality of life. performing safe and accurate pain management practices in the elderly can improve their performance, quality of life, increase their comfort and reduce their care costs. in this study, it was aimed to investigate the effect of pain management education in individuals with knee osteoarthritis with chronic pain.

Eligibility criteria:
inclusion criteria: * to be diagnosed with knee oa according to the criteria of the american college of rheumatology (acr) * be between 45 and 75 years old * stage 2-3 according to kellgren lawrence (k-l) in the radiological examination exclusion criteria: * having active synovitis * receiving physical therapy in the last 6 months * people with neurological problems that affect walking * those with arthritis in the ankle and hip joint * those with serious respiratory, central, peripheral, vascular and uncontrolled metabolic problems that will prevent exercise. * have had surgery on the lower extremity in the past * intra-articular steroid injections in the last 6 months * use of psychoactive drugs

Keywords: osteoarthritis pain management activities of daily living quality of life tele-education
effectiveness of vistao2 flux device in screening of sleep apnea/hypopnea syndrome

Conditions: Sleep Apnea Syndromes

Summary: the high prevalence (9% in men and 4% in women) of sleep apnea / hypopnea syndrome (sahs) in adults is now well documented as well as its cardiovascular repercussions. previous studies showed a conclusive link between sahs and severe cardiovascular diseases such as hypertension, myocardial infarction, heart failure and stroke.then, sahs is a public health issue in adults. in this context, early detection of such a disease is crucial if the management is tailored to the patient, the practitioner's choice of therapy moving towards continuous positive airway pressure (cpap) or mandibular advancement device. the detection is based on full nocturnal polysomnography or polygraphic recordings. polysomnography remains the gold standard but it is a time consuming and costly examination. polygraphic recording is a test that allows simplified the diagnosis of severe patients, but may not be sufficient for mild form of sahs. thus, the sahs is a pathology under-diagnosed and under-treated. the validation of a technique for identifying patients most at risk to either limit the number of polysomnographic examination is requested.

in this perspective, the development of a product screening sleep related breathing disorders for physicians, cardiologists, internists (not specialized sleep experts) would fill this need. it allows for a reliable first screening for their patients in parallel with a routine cardiological examination. imposing a minimal human and material, the ecg holter recorder "vistao2 flux" (novacor, rueil-malmaison, france) is a device designed to meet these requirements. this device fits into the daily management of patients with cardiac arrhythmias or sinus/atrioventricular conduction disorders, and of patients suffering myocardial infarction (arrhythmic risk stratification, detection of silent myocardial ischemia). analysis of heart rate variability (hrv) has already shown interest in screening sahs. we therefore wish to evaluate the performance of the analysis of data from the screening tool vistao2 flux face what the gold standard synchronized polysomnography.

Eligibility criteria:
inclusion criteria: * sleep apnea hypopnea syndrome suspicion * written consent exclusion criteria: * pacemaker * diabetes * atrial fibrillation * electrode allergy

Keywords: sleep apnea syndromes polysomnography holter ecg thoracic impedance heart rate variability nasal flow
treatment of breast pain using a medication (diclofenac) applied to the skin

Conditions: Breast Pain; Non-cyclical Mastalgia; Surgical Scar-Related Breast Pain

Summary: the study was a randomized, double-blinded, crossover trial of topical diclofenac and placebo (10 weeks of each) for the treatment of noncyclic breast pain.

a prospective, randomized, double-blinded crossover trial comparing topical diclofenac and placebo for 10 weeks in the treatment of 30 women with noncyclic mastalgia and surgical scar-related breast pain.

Eligibility criteria:
inclusion criteria * noncyclic mastalgia or surgical scar-related pain occurring at least 2 days per week and for which the patient desires treatment * duration of pain \> 2 months (noncyclic mastalgia) or \> 4 months (surgical scar-related pain) * age \> 18 years * satisfactory breast examination and directed ultrasound at site of pain (all ages) within 12 months * satisfactory mammogram (all women \> 30 years of age) within 12 months * negative pregnancy test (all women who are premenopausal and have not had hysterectomy or tubal ligation) exclusion criteria * cyclic mastalgia (as defined above) * duration of pain \> 2 months (noncyclic mastalgia) or \> 4 months (surgical scar-related pain) * abnormal breast examination or imaging (abnormality at the site of pain or for which biopsy or surgical consultation is recommended) * known pregnancy, lactation, positive pregnancy test, or anticipated pregnancy within 6 months * asthma, that has been aggravated by oral nonsteroidal antiinflammatory agents * allergy, to diclofenac or any nonsteroidal antiinflammatory agents * rash or open lesions at the site on the breast where the topical agent would be applied * incomplete or abnormal healing (surgical scar-related pain) * history of gastrointestinal ulceration, renal dysfunction (creatinine \> 1.5), hepatic disease (known liver disease or aspartate aminotransferase (ast) twice normal levels), congestive heart failure and uncontrolled hypertension (blood pressure \> 140/90)
hearing and balance disorders in peripheral neuropathy

Conditions: Charcot-Marie-Tooth Disease

Summary: the long term goal of this proposal is to precisely characterize the auditory and vestibular abilities of children with charcot-marie-tooth (cmt) and how these abilities evolve during the progression of the disorder. this information will be used to refine the management methods for hearing loss and vestibular disorders in these patients. given that the phenotypic severity is variable within the cmt patient population, we predict that not all cmt patients will present with auditory and vestibular dysfunction. we will therefore collect specimens (i.e., buccal swabs and saliva) from study participants so that their dna can be isolated and used to determine the genetic basis for auditory and vestibular dysfunction in peripheral neuropathies.

aim #1: evaluate the prevalence of auditory and vestibular disorders in children diagnosed with charcot-marie-tooth. we hypothesize that a significant number of children with charcot-marie-tooth (cmt) will develop auditory and vestibular neuropathies, due to the progression of the disorder. we will examine the characteristics of auditory and vestibular abilities of children and how these relate to the type of cmt. aim #2: examine the progression of hearing and vestibular abilities during the course of the disorder. we hypothesize that the hearing and vestibular abilities of some children with cmt will deteriorate with time. we will repeat the auditory and vestibular testing on a yearly basis to precisely describe the progression of these abilities.

Eligibility criteria:
inclusion criteria: * individuals diagnosed with charcot-marie tooth exclusion criteria: -