Kornimate/medical-research-clean huggingface dataset:
assessment of tender & swollen joints count score performed by a rheumatologist and rheumatology nurses in patients with ra and psa.

Conditions: Rheumatoid Arthritis; Psoriatic Arthritis

Summary: this study will establish a comparison in follow-up care of 100 patients between health care practitioners, more specifically the rheumatologist and a trained nurse. the study objective is to show consistency of evaluation between two different health care professionals, a physician and a nurse.

this study involves one site in canada. patients will complete a self-evaluation of 28 joint counts for swelling (sjc) and tenderness (tjc) and assess their disease activity on a visual analog scale (vas). a 28 joint count and vas will then be assessed by a nurse and by a rheumatologist. clinical disease activity index (cdai) and disease activity severity 28 - c reactive protein (das28-crp) will be calculated from each data set. the same rheumatologist will examine all patients and two nurses will each randomly assess half the total enrolled patients. the nurse will be blinded to the patient's joint count and vas, and similarly, the rheumatologist will be blinded to both the patient and nurse's assessments. the setting includes 2 nurses with different educational background: one technician and one bachelor. the training provided to the nurses in this study allows them to master the basis of the physical exam, joint count and history of the rheumatoid patient as well as to learn the pertinent laboratory parameters. it is a 14-hour course in which the patient is examined through observation, palpation, assessment of mobility and stability and specific movement. diagnostic tools such as the simplified disease activity index (sdai), health assessment questionnaire disability index (haq), cdai and das-28 are included in the patient evaluation. each enrolled patient will receive a 5-minute training in joint assessment by the nurse. the use of the mannequin for joint assessment of swelling and tenderness will be reviewed. objective signs of disease such as swelling, redness and heat will be explained as well as the difference between inflammation and bony swelling, the latter being indicative of osteoarthritis.

Eligibility criteria:
inclusion criteria: 1. subject is ≥18 years of age. 2. has at least one of the following diagnosis at screening * subject has a diagnosis of ra as defined by the 1987- revised american college of rheumatology (acr)- classification criteria for ra and has disease duration of more than 6 months. * subject must have a diagnosis of active psa by classification criteria for psoriatic arthritis (caspar) and has disease duration of more than 6 months. 3. the subject must be able to provide written informed consent and to complete the study questionnaires. exclusion criteria: * subject with dip involvement in psa * subject with predominant axial symptoms (spondyloarthropathy) * subject with fibromyalgia * subject involved in a concomitant study * subject currently takes ≥10 mg cortisone daily * subject has taken opioid analgesics within 12 hours of joint count assessment
18-month clinical evaluation of self-adhesive flowable giomer compared to conventional flowable giomer in carious cervical lesions: a randomized clinical trial

Conditions: Cervical Caries

Summary: the material under investigation will offer the patient a high strength and high durability restoration with the advantage of having anti-bacterial properties.

there is no available evidence for assessing fit sa restorative material in restoration of cervical lesions. therefore, this study aims to provide valuable insights into the shear bond strength and clinical performance, in terms of the biological, mechanical and esthetic parameters, of fit sa restorative material in restoration of cervical lesions.

Eligibility criteria:
inclusion criteria: 1. cervical carious lesions in anterior teeth and premolars 2. small to moderate class v carious lesion (icdas 3 \& 4). 3. vital upper or lower periodontally sound teeth with no signs of irreversible pulpitis. 4. presence of favorable occlusion and teeth are in normal contact with the adjacent teeth exclusion criteria: 1. cervical carious lesions in molars. 2. deep carious defects (close to pulp, less than 1 mm distance). 3. teeth with clinical symptoms of pulpitis such as spontaneous pain or sensitivity to pressure. 4. non-vital teeth, fractured or cracked teeth. 5. endodontically treated teeth. 6. periodontally affected teeth

Keywords: self-adhesive giomer bioactive randomized clinical trial. usphs criteria carious cervical lesion class v clinical performance fit sa beautifil flow plus
predictive factors for postoperative pain, nausea and vomiting in oncological patients

Conditions: Nausea; Vomiting; Pain, Postoperative

Summary: 1809 patients were evaluated in postoperative period. they were asked about nausea, vomiting, retching and pain in the first postoperative 24 hours

patients were prospectively evaluated , and nausea, vomiting and pain were recorded.

Eligibility criteria:
inclusion criteria: * patients submitted to oncological surgeries exclusion criteria: * refusal to sign the agreement term * lack of information in the records

Keywords: nausea vomiting pain
a long-term safety and efficacy study of eszopiclone in elderly with primary chronic insomnia

Conditions: Insomnia

Summary: to evaluate the long-term safety and efficacy of eszopiclone administered for 12 weeks in elderly subjects with primary chronic insomnia.administration of eszopiclone 2 mg daily at bedtime for 12 weeks in elderly subjects with a diagnosis of primary chronic insomnia will be safe and well tolerated, improve subjective sleep measures, improve measures of quality of life and next day insomnia symptoms, and have no significant withdrawal central nervous system adverse events or rebound insomnia.

a double-blind, randomized, placebo controlled, parallel group study of eszopiclone in elderly subjects with primary chronic insomnia. the study will involve up to 9 visits and subject participation will be approximately 18 weeks. this study was previously posted by sepracor inc. in october 2009, sepracor inc. was acquired by dainippon sumitomo pharma., and in october 2010, sepracor inc's name was changed to sunovion pharmaceuticals inc.

Eligibility criteria:
inclusion criteria: * male and female subjects with primary chronic insomnia. subject is otherwise in good general health, based on screening physical examination and medical history. exclusion criteria: * subject has recent history of known clinically significant abnormal laboratory findings.

Keywords: insomnia chronic primary
percutaneous treatment of long native coronary lesions with drug-eluting stent-vii: sirolimus-eluting (ultimaster) vs. everolimus-eluting stents (xience)

Conditions: Coronary Artery Disease; Coronary Stenosis

Summary: this study compares angiographic and clinical outcomes in patients with long coronary lesions treated with sirolimus-eluting stent (ultimaster stent) or everolimus-eluting stent (xience alpine stent). the study uses a randomized, multicenter, controlled design approach.


Eligibility criteria:
inclusion criteria: 1. the patient must be at least 19 years of age. 2. significant native coronary artery stenosis (\>50% by visual estimate) with lesion length of more than 25mm, which requiring at long stent placement without intervening normal segment. 3. patients with silent ischemia, stable or unstable angina pectoris, ad non-st-elevation myocardial infarction (nstemi) 4. the patient or guardian agrees to the study protocol and the schedule of clinical and angiographic follow-up, and provides informed, written consent, as approved by the appropriate institutional review board/ethical committee of the respective clinical site. exclusion criteria: 1. any contraindication to any of the following medications: aspirin, heparin, clopidogrel, stainless steel, contrast agents, sirolimus, or everolimus 2. an elective surgical procedure is planned that would necessitate interruption of antiplatelet drugs during the first 6 months post enrollment. 3. acute st-segment-elevation mi or cardiogenic shock 4. terminal illness with life expectancy \<1 year 5. in-stent restenosis at target vessel (either bare metal stent or drug-eluting stent segment). however, non-target vessel isr is permitted. 6. patients with ef\<30%. 7. serum creatinine level ≥ 2.0mg/dl or dependence on dialysis. 8. patients with left main stem stenosis (\>50% by visual estimate)

Keywords: drug eluting stent everolimus eluting stent sirolimus eluting stent
hip reconstruction in cerebral palsy with pelvic osteotomy

Conditions: Cerebral Palsy

Summary: prospective study enrolling patients with cerebral palsy and with subluxation of the hips \> 40% and acetabular dysplasia. the patients will be stratified according the degree of subluxation and age. the treatment protocol is composed by femur variation osteotomy and periacetabular osteotomy. patients will be divided in two groups according the type of bone graft used at periacetabular osteotomy (autologous or ceramic).


Eligibility criteria:
inclusion criteria: * hip subluxation \> 40% and acetabular dysplasia exclusion criteria: * previous hip surgery

Keywords: cerebral palsy hip luxation subluxation
dotarem®-enhanced mra compared to gadovist®-enhanced mra in patients with abdominal or lower limb arterial diseases

Conditions: Peripheral Arterial Disease

Summary: this study is an intra-individual comparison of dotarem®-enhanced mra and gadovist®-enhanced mra in the diagnosis of clinically significant abdominal or lower limb arterial diseases.


Eligibility criteria:
inclusion criteria: * female or male, aged ≥ 18 years * patient suffering from peripheral arterial occlusive disease (paod) stage ii or iii. exclusion criteria: * patients with severely impaired renal function with an egfr (mdrd) \< 50ml/min (egfr based on recent serum creatinine and mdrd formula - younger than 21 days). * patient planned to undergo therapeutic intervention in the vessels of interest between the two mra procedures. * patient who had a major cardiovascular event within 30 days prior to the inclusion.

Keywords: dotarem gadovist peripheral arterial disease mra
impact of short-course colchicine versus placebo after pulmonary vein isolation (improve-pvi pilot)

Conditions: Atrial Fibrillation; Recurrence

Summary: recurrence is a common problem after catheter ablation for atrial fibrillation, affecting at least one out of three patients. inflammation due to the procedure may contribute to pulmonary vein reconnection and, thus, failure of catheter ablation. this pilot study will assess whether a randomized, placebo-controlled, double-blind trial investigating a 10-day treatment with colchicine, a potent anti-inflammatory drug, to improve patient relevant outcomes after catheter ablation for atrial fibrillation is feasible.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years 2. symptomatic atrial fibrillation and planned catheter-guided first or repeat ablation (pulmonary vein isolation) for atrial fibrillation (radiofrequency or cryoablation energy; concomitant ablation of the cavotricuspid isthmus and other lesions left at the discretion of the treating physician) 3. written informed consent exclusion criteria: 1. ablation for left atrial tachycardia or isthmus-dependent atrial flutter only (i.e. without pulmonary vein isolation) 2. administration of a strong inhibitor of cyp3a4 or p-gp (clarithromycin, erythromycin, telithromycin, cyclosporine, ketoconazole or itraconazole) 3. known hypersensitivity to colchicine 4. serious gastrointestinal disease (severe gastritis or diarrhea) 5. clinically overt hepatic disease 6. severe renal disease (egfr\< 30ml/min/1.73m2) 7. clinically significant blood dyscrasia (e.g., myelodysplasia) 8. absolute indication for or ongoing treatment with colchicine 9. pregnant or breastfeeding women, or women of child-bearing potential who do not use a highly effective form of birth control
the balance influence of shoe inserts on motor development delayed children

Conditions: Development Delay

Summary: flatfoot, one of the most common foot problems experienced by preschool-aged children, characterized by the collapse of the foot's medial longitudinal arch. children with motor developmental delay often have flatfoot, according to clinical observation, and research indicates that preschool age is the main stage of the medial longitudinal arch development period. there flatfoot symptoms due to poor arch shock effect, poor walking endurance, likely to cause gait problems while growing up. the lack of a stable foot structure to support and maintain posture may lead to delayed motor development. early training intervention and help to balance stability is the main rehabilitation goal for motor developmental delayed children. with understanding of the foot development of motor development delayed children, proper intervention can be provided to improve the movement and stability of the lower limbs. the possible deformation of the foot structure and resultant pain in the future can also be prevented.

the investigators designed a prospective cohort study to long-time follow up of preschool aged children with delayed motor development and to establish standard data, including the foot shape, footprint and balance development. the investigators also discuss the influence of the shoe insert with balance and flatfoot correction. flatfoot leads to poor gross motor balance and the balance improvement after flatfoot correction has never been studied. the investigators findings should provide direct evidence as a reference for clinical workers.

Eligibility criteria:
inclusion criteria: * preschool aged children with delayed motor development exclusion criteria: 1. lower limb injury case in six months. 2. other neurological history such as cerebral palsy, traumatic brain injury, spina bifida to cause of developmental delay. 3. have been or are receiving insoles correction or treatment. 4. can not be completed with the instruction by foot measurement and balance measurement.

Keywords: motor development delay balance flatfoot shoe insert
mindfulness psychoeducation for bipolar disorder caregivers' mindfulness, burden, quality of life and resilience

Conditions: Bipolar Disorder

Summary: this study was designed to determine the effect of mindfulness-based psychoeducation applied to primary caregivers of individuals diagnosed with bipolar disorder on their mindfulness, caregiver burden, quality of life, and psychological resilience.

bipolar disorder is a chronic mental illness characterized by alternating episodes of opposing mood states (mania/hypomania and depression) and euthymic periods. providing continuous care to individuals diagnosed with bipolar disorder can be highly challenging. considering factors such as medication management, hospital follow-ups, patient behavior during episodes, and their attitudes toward themselves and others, being a primary caregiver is a demanding responsibility. caregivers may face challenges such as constant caregiving burden, social isolation, burnout, neglecting self-care, and ignoring their own need for help. however, due to their perceived obligation to prioritize the patient, they may find themselves without adequate support. psychiatric nurses should approach not only the chronically mentally ill patient but also their caregivers, who are integral parts of the patient's environment, from a holistic perspective. the home environment of the patient, and particularly the attitude of the family and primary caregiver, plays a significant role in the prevention of relapses. from this holistic point of view, psychoeducation programs are expected to increase caregivers' psychological resilience, quality of life, and mindfulness levels, while reducing their caregiving burden. such outcomes are anticipated to not only benefit the caregiver and the patient but also strengthen the broader society, as they may contribute to the reduction of relapse rates. consequently, this could positively impact the national economy by decreasing healthcare utilization. protecting caregivers may also lead to a reduced need for healthcare services directed toward them. psychoeducation is one of the core roles of psychiatric nurses. the recognition and expansion of mindfulness-based psychoeducation practices in the field are expected to provide significant support to both patients and their families.

Eligibility criteria:
inclusion criteria: * aged 18 years or older, * at least a primary school graduate, * able to hear, understand spoken language, and communicate, * has been a primary caregiver for at least 6 months and is participating voluntarily. exclusion criteria: * currently participating in another psychoeducation group, * diagnosed with any mental disorder.
efficacy of aspirin in preventing venous thromboembolism

Conditions: Venous Thromboembolism (VTE); Total Joint Arthroplasty; Total Hip Arthroplasty (THA)

Summary: efficacy of aspirin and enoxaparin in preventing venous tromboembolism was compared after total knee or hip arthroplasty.

background: venous thromboembolism (vte) remains a significant risk following joint replacements, despite advancements in prevention strategies. aspirin-based therapies have gained popularity due to their perceived safety, ease of administration, and supportive evidence.this study aimed to compare the efficacy of aspirin and enoxaparin in preventing vte after total knee or hip arthroplasty. methods: sixty patients undergoing primary total knee or hip arthroplasty were randomized to receive either aspirin or enoxaparin. the primary outcome was symptomatic vte within 90 days. patients were followed up for doppler ultrasound evaluations.

Eligibility criteria:
inclusion criteria: * all patients provided written informed consent. * all patients who underwent primary total hip or total knee arthroplasty for osteoarthritis exclusion criteria: * preoperative anticoagulation (direct oral anticoagulant, warfarin, improve bleeding score more or equal to 7, dual antiplatelet therapy) * medical contraindications (allergy, cancer, cardiac disease, kidney disease, or bleeding disorder precluding anticoagulation).

Keywords: aspirin venous thromboembolism total knee replacement total hip replacement thromboprophylaxis
comparison between deep sclerectomy and traditional trabeculotomy & trabeculectomy in congenital glaucoma

Conditions: Congenital Glaucoma

Summary: the investigators hypothesize that deep sclerectomy in congenital glaucoma is a safer procedure and may yield better results than trabeculotomy trabeculectomy approach.

non penetrating glaucoma surgery depends on filtration through trabeculo-descmeto window as well as supra-choroidal space less to sub-conjunctival rout. the nature of the operation keeps the globe intact without penetration that leads to less complications compared to penetrating trabeculectomy combined with trabeculotomy.

Eligibility criteria:
inclusion criteria: * any case diagnosed as congenital glaucoma with enlarged corneal diameter more than 11 mm and intra-ocular pressure above 21 mmhg, including corneal edema or habb's stria with or without optic disc cupping. * any case diagnosed as primary or secondary congenital glaucoma to ocular or systemic abnormalities. * within the age of (0 - 12). exclusion criteria: * cases of congenital glaucoma with previous intervention. * age above 12 yrs. * cases with secondary glaucoma caused by surgical intervention, ocular co-morbidity, medications or trauma
trauma heart to arm time

Conditions: Trauma; Hypovolemia; Hemorrhage

Summary: in the prehospital setting it would be helpful to assess primary changes in central blood volume or preload (venous return, stroke volume, diastolic ventricular volume) that occur during the stability phase following injury when regulatory mechanisms are still functioning. obviously in this setting a non invasive bedside beat-to-beat index would be helpful. pulse transit time (ptt) is the sum of pre-ejection period (pep), the time interval between the onset of ventricular depolarization and the ventricular ejection, and vascular transit time (vtt), the time it takes for the pulse wave to travel from the aortic valve to the peripheral arteries (obrist et al. 1979). pep variations are known to correlate with reductions in central blood volume induced by head-up tilt (chan et al., 2007b, 2008). the same authors also demonstrated that ptt variations follow closely pep variations and therefore central blood volume variations (chan et al., 2007b). following central blood volume reductions induced by head-up tilting ventricular diastolic filling time increases involving an increase in pep and ptt. chan et al. (chan et al., 2007b) concluded that ptt could have been used to assess early central hypovolemia and suggested that joint analysis of ptt and rr intervals could help in predicting the extent of blood volume loss. the investigators hypothesized that sympathetic drive associated with trauma would act on cardiac contractility through beta activity thus shortening ptt without reducing rr interval to the same extent in healthy hearts. we also hypothesized that progressive hypovolemia would lead to a rising of ptt (augmented diastolic filling time) and a rr interval shortening (relative tachycardia). in this study the investigators propose and index based on the beat-to-beat ptt/rr ratio to assess central hypovolemia in traumatic patients enrolled by our helicopter emergency medical system (hems) in a prehospital setting.


Eligibility criteria:
inclusion criteria: * all trauma victims enrolled by our helicopter emergency medical system (hems) exclusion criteria: * need of immediate life-saving manoeuvres as decided by onboard physician following prehospital trauma care (ptc) criteria (citation ptc) * cardiac arrest * presence of preexisting chronic illnesses involving the autonomic nervous system such as hypertension, diabetes and any neurological disease * any preexisting medical therapy including those administered by the emergency medical team as defined in point 1) * presence of supraventricular ectopic beats more than 5% of total recorded beats * absence of sinus rhythm * presence of intraventricular or bundle branch blocks or artificial pacemaker * spinal chord trauma above d2 * patient age \<18 years * presence of burns not allowing monitoring

Keywords: trauma hypovolemia hemorrhage out of hospital trauma
acute hamstring strains in danish elite soccer - diagnosis and biomechanical tests

Conditions: Strains

Summary: a common soft tissue injury in sports involving sprinting and jumping is the hamstring strain. in addition to the frequency of injury, hamstring injuries are also the most recurrent soft tissue injury occurring in sport. there is a need for further research concerning diagnosis and different prognostic parameters for the rehabilitating process. the aims for this study are: a longitudinal comparison of sonographic and mri assessments of acute and healing hamstring injuries. a study investigating different biomechanical parameters in the process of determining whether a former hamstring injured soccer player is fully rehabilitated. we hypothesize that it is possible to use electromyography, muscle strength measurements and different tests on a force platform to help determine this issue.


Eligibility criteria:
inclusion criteria: * acute hamstring strain caused during soccer activities (match or training) exclusion criteria: * a hamstring strain at the time for inclusion

Keywords: hamstring strain rehabilitation muscles