Kornimate/medical-research-clean huggingface dataset:
rahm foundation retrospective study of various diseases

Conditions: Pain, Spinal Surgeries, Hip and Knee Joint Replacement, Adverse Events

Summary: this is a retrospective data collection on treatment of various disorders. this registry will include a variety of different products, implants, technologies and procedures. the registry will also collect any adverse events/complications that occur during or following treatment of these conditions. the data may be utilized to develop strategic treatment pathways and/or benchmarking that will improve patient care. ultimately, the goal of the registry is to enhance the understanding of healthcare and the treatment in these disease states.

the purpose is to collect data on patients with a variety of disorders. this includes point of care (primary care, internal medicine, pain management providers, etc.) as well as a variety of specialty providers including neurosurgeons, orthopedic surgeons, oncologists, and dermatologists. the retrospective data collection will consist of a core set of data if available. the registry will attempt to collect data prior to surgery/treatment/procedures, during surgery, and various time points following surgery/treatment/procedures. the data will include, but is not limited to demographic data, past medical history, previous treatments, time off of work, type of surgery performed, products/implants/procedures/technology used during surgery, treatments/procedures/technology used for non-surgical conditions, anesthesia used during surgery, complications/adverse events following surgery and or treatment, outcome tools, imaging results, pain assessment, pain medication utilization, length of hospital stay, unplanned hospital admissions, revision surgery, adjacent level disease, genetic testing, urinary drug testing, other diagnostic or assessment testing, patient return to work and patient return to normal activity. the data collected will vary depending on disease state and treatment. this registry will also allow for comparisons on different treatments, procedures, etc. with a goal of developing the best pathways for a variety of different disease states.

Eligibility criteria:
inclusion criteria: * subjects who meet eligibility criteria across 1 of the 6 therapeutic areas exclusion criteria: * subjects who do not meet eligibility criteria for any of the 6 therapeutic areas
suprascapular nerve block in patients rehabilitated after arthroscopic rotator cuff repair

Conditions: Rotator Cuff Tears; Pain; Nerve Block

Summary: suprascapular nerve block is an injection method that has been shown to be effective in shoulder rehabilitation in diseases such as adhesive capsulitis and stroke .. applying the block under usg guidance instead of blinding increases the effectiveness and reduces complications.

suprascapular nerve block is an injection method that has been shown to be effective in shoulder rehabilitation in diseases such as adhesive capsulitis and stroke .applying the block under usg guidance instead of blinding increases the effectiveness and reduces complications there are many studies in the literature on suprascapular, axillary, and interscalene nerve blocks in early pain management after shoulder arthroplasty. all of these focus on pain in the perioperative or early postoperative period. there is a study on usg-guided suprascapular nerve block. in this study, unlike the studies in the literature, it was aimed to show the effectiveness of usg-guided suprascapular nerve block in the subacute rehabilitation process of patients.

Eligibility criteria:
inclusion criteria: -having undergone arthroscopic rotator cuff repair surgery within the last week exclusion criteria: * history of previous surgery on the same shoulder * history of systemic inflammatory rheumatological disease * neurological diseases with muscle weakness in the upper extremity (ms, als, muscular -dystrophy) * history of malignancy, pregnancy, breastfeeding * use of steroids or immunosuppressive drugs * history of allergic reactions to local analgesics * fibromyalgia syndrome * chronic painful conditions that require opioid use * presence of known psychiatric disease * cognitive impairment (mini mental test score \<23)

Keywords: rotator cuff tears pain nerve block rehabilitation
neivatech virtual reality-based system for amblyopia

Conditions: Amblyopia

Summary: the neivatech system has been designed to provide binocular vision training to 7-15 year old amblyopic children by discriminating gabor patches presented with different contrast to each eye as a perceptual learning task.

due to the global impact of amblyopia, there is a medical and social need, and at the same time, a clear market niche, for the design and development of new therapies that can improve recurrence rates and non-compliance with conventional treatments. in this sense, the aim of this single-arm, multicentre, prospective pilot study is to examine the safety, acceptability and clinical efficacy of a novel virtual reality-based system designed to provide binocular vision training to 7-15 year old amblyopic children complementing the concepts of perceptual learning and dichoptic training with a gamification approach.

Eligibility criteria:
inclusion criteria: * children aged between 7 and 15 years. * va in the amblyopic eye \< 0.1 logmar units. * interocular difference in va ≥ 1 logmar line. * interocular difference in espherical equivalent ≥ 1 d. * interpupillary distance (ipd) between 60.7 and 73.5 mm. * use of best refractive correction for at least 2 months prior to inclusion. * lack of response or therapeutic adherence to conventional occlusion therapy. * willingness to attend all the active vision therapy sessions and/or visits of the study. * no history of previous treatment for amblyopia other than optimal refractive correction for at least 2 months prior to inclusion. exclusion criteria: * active eye disease. * previous ocular surgery. * bcva in the amblyopic eye of ≥ 0.70 logmar. * presence of cognitive impairment or neurological or psychiatric disorders. * presence of irregular cornea due to astigmatism or ectatic corneal disease.

Keywords: amblyopic children perceptual learning dichoptic training virtual reality gamification
sarcopenia and mechanical ventilation in older patients admitted due to covid-19

Conditions: Sarcopenia

Summary: the sarcov study aims at assessing the association between sarcopenia and the indication of mechanical ventilation in older hospitalized patients due to covid-19 infection

sarcopenia is disease associated with poor clinical outcomes. in critical ill chirurgical patients, sarcopenia is associated with difficult to wean of mechanical ventilation. the association between sarcopenia and mechanical ventilation is poorly studied in medical patients. covid-19 pandemic has led a lot of medical patient to be admitted in intensive care units due to acute respiratory failure with need of mechanical ventilation support. the primary objective is to determine if sarcopenia in critically-ill older patients with covid-19 is associated with the indication of mechanical ventilation. secondarily, the study aims at determining if sarcopenia is associated with difficult to wean and mortality in critically-ill older patients with covid-19.

Eligibility criteria:
inclusion criteria * consecutive patients aged 60 and older * admission in an acute care unit in brugmann university hospital due to a covid-19 possible or confirmed infection. a infection was considered confirmed in presence of a positive molecular test by polymerase-chain reaction (pcr), following the belgian public health department recommendations (sciensano recommendations). exclusion criteria * patients unable to perform a grip-strength measurement due to any rheumatological or neurological condition.

Keywords: sarcopenia mechanical ventilation older patients covid-19
a research study looking at how oral semaglutide works in people with type 2 diabetes in germany, as part of local clinical practice

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of the study is to collect information on how rybelsus® works in people with type 2 diabetes and to see if rybelsus® can lower their blood sugar levels. participants will get rybelsus® as prescribed to them by the study doctor. the study will last for about 34-44 weeks. participants will be asked to complete questionnaires about how they take their rybelsus® tablets. participants will complete the questionnaires during their normally scheduled visit with the study doctor.


Eligibility criteria:
inclusion criteria: * signed consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol). * diagnosed with type 2 diabetes mellitus. * the decision to initiate treatment with commercially available oral semaglutide has been made by the patient/legally acceptable representative (lar) and the treating physician based on local label before and independently from the decision to include the patient in this study. * male or female, age above or equal to 18 years at the time of signing informed consent. * available hba1c value less than or equal to (≤) 90 days prior to the 'informed consent and treatment initiation visit' (v1) or hba1c measurement taken in relation with the 'informed consent and treatment initiation visit' (v1) if in line with local clinical practice. * treatment naïve to injectable glucose-lowering drug(s). an exception is short-term insulin treatment for acute illness for a total of less than (\<) 14 days. exclusion criteria: * previous participation in this study. participation is defined as having given informed consent in this study. * treatment with any investigational drug within 30 days prior to enrolment into the study. * mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation.
electro-acupuncture at zusanli, qihai, and guanyuan acupoints regulate immune function in patients with sepsis

Conditions: Sepsis; Immune Dysfunction

Summary: the purpose of this study was to investigate the biochemical and clinical effects of electro-acupuncture in patients with sepsis.

patients were randomly divided into an electro-acupuncture (ea) group and a western medicine group(wm group) using restricted block randomization (1:1 ratio). patients in the western medicine group received conventional treatment with western medicine. according to the international guidelines for management of sepsis and septic shock: 2016, conventional treatment includes antibiotics and other anti-infection measures, fluid management, mechanical ventilation, and nutritional support, but did not include the use of immunosuppressants or immune enhancers including hormones, gamma globulin, and thymosin. patients in the electro-acupuncture group were treated with western medicine and electro-acupuncture. electro-acupuncture was given at the zusanli (st36), guanyuan (cv4), and qihai (cv6) acupoints, twice a day for 30 minutes, and for 5 days in total. the indicators of immune dysfunction including the percentage of t lymphocyte subsets, percentage of natural killer (nk) cells, and serum soluble programed cell death protein (spd-1) level, and clinical effect including apache-ii and sofa score, whole blood analysis, levels of tumor necrosis factor-α (tnf-α) and c-reactive protein (crp), were determined before treatment and after treatment for 5 days.

Eligibility criteria:
inclusion criteria: * diagnosis of sepsis; * signed the informed consent form. exclusion criteria: * pregnancy or psychiatric disorder; * immune deficiency or using immunosuppressants or immune enhancers; * history of malignancy; * hiv positive; * unwilling to participate in the study or cooperate with the treatment. patients who cannot tolerate electroacupuncture treatment or loss of follow-up for complicating with other diseases during the study would be dropped off.

Keywords: sepsis immune dysfunction electro-acupuncture
iohexol clearance in critically ill patients with augmented renal creatinine clearance

Conditions: Augmented Renal Clearance; Critically Ill

Summary: evaluation of glomerular filtration rate using iohexol plasma clearance in critically ill patients with augmented renal creatinine clearance

single center study in icu patients with augmented renal clearance comparing glomerular filtration rate (gfr) as measured by iohexol plasma clearance to that measured by creatinine clearance. primary objective is to compare the gfr estimates made by iohexol plasma clearance (as reference method) and creatinine clearance using bland-altman method. secondary objective are to compare gfr as measured by iohexol plasma clearance to that calculated with the most commonly used renal clearance estimating formulas (cockcroft and gault, mdrd and ckd-epi ), evaluate clinical determinant of the observed differences and evaluate determinants of extracellular volume.

Eligibility criteria:
inclusion criteria: * icu patient * 24h creatinine clearance \>130ml/min/1.73m2 * urinary catheterization * affiliation to a social security scheme exclusion criteria: * pregnancy * ct-scan with contrast media infusion the day of inclusion * documented allergy to contrast media * patient under guardianship / curatorship * patient benefiting from the "state medical assistance"

Keywords: iohexol augmented renal clearance intensive care unit
the effect of an oral supplement,tk3 (tryptophan and thiamine) on the quality of life and chemotherapy tolerance in cancer patients with advanced disease.

Conditions: Cancer; Quality of Life; Chemotherapy Effect; Tryptophan; Thiamine

Summary: the product under investigation relates to a pharmaceutical composition containing a pyrimidine nitrogen base, thymine, and the essential amino acid tryptophan. this product seems to have effect on quality of life and enhance adverse affects of chemotherapy in cancer patients.

the primary objective of this study is to evaluate the impact of tk3 on the quality of life of patients receiving anti-neoplastic chemotherapy. the secondary objectives are to evaluate the influence of tk3 on the side effects caused by anti-neoplastic chemotherapy, tolerance to this treatment and the safety of the use of the tk3 product in cancer patients, accompanying the appearance of non-characteristic effects of the existing cancer type .

Eligibility criteria:
inclusion criteria: * patients who agree to study procedures and sign the informed consent * patients 18 years of age or older; * patients undergoing oncologic treatment for advanced neoplasms. it is understood by advanced patient disease patients with unresectable or with distant metastases. * participants should present at least one (1) of the following clinical side effects that can be assessed according to ctcae (version 4.0): fatigue, nausea, vomiting, diarrhea, or mucositis. * patients with programming to receive at least 3 cycles of anti-neoplastic chemotherapy; * patients may be on radiotherapy exclusion criteria: * use of vitamin complex or concomitant food supplement; * current use or programming of parenteral diet use; * hypersensitivity to the components of the formula; * participation in another clinical study or use of any investigational product within 28 days prior to commencement of treatment in this clinical trial, unless the investigator deems there to be a clinical benefit therefore;
the cervical cap in the diagnosis of rupture of membranes in the second trimester

Conditions: Fetal Membranes, Premature Rupture; Ultrasonography

Summary: early preterm premature rupture of membranes (pprom) complicates 0.7% of pregnancies. when pprom occurs before the 24th week,the risk of fetal and neonatal death is 70%. there is also a high risk of neonatal and maternal morbidity. when the diagnosis of pprom is uncertain by physical examination, additional tests are needed. these tests have false positive and false negative rates. the gold standard for diagnosing pprom is amniocentesis and dye test. this procedure has a risk of infection and abortion.our hypothesis is that by using a cervical cap for 6 hours and repeated ultrasound exams we can diagnose or rule out pprom in cases which are uncertain. our study group will be pregnant women gestational age 14-23, suspected of having pprom.


Eligibility criteria:
inclusion criteria: * gestational age 14-23 * single fetus * suspected rupture of membranes * oligohydramnios exclusion criteria: * vaginal bleeding * suspected chorioamnionitis

Keywords: pregnancy
mindfulness-based cognitive therapy effect on depression and c-reactive protein levels after 8 weeks of treatment

Conditions: Major Depressive Disorder

Summary: this study will investigate the efficacy of an 8-week course in mindfulness-based cognitive therapy (mbct) for adults with major depressive disorder (mdd) by ;measuring change from baseline to completion of treatment at 8 weeks in terms of depression severity using the hamilton depression ratings scale. we will measure change in c-reactive protein, a measure of inflammation, over the same time period.

this study will investigate the effectiveness of mbct as a primary treatment for mdd. twelve unmedicated subjects with mdd were enrolled in the study. all subjects with mdd underwent depression severity assessment at baseline and after the 8-week intervention was complete to measure change. in addition, the subjects underwent blood sampling at the same time points to measure c-reactive protein change over the 8 weeks. the primary goal of this pilot study is to determine the efficacy of mbct as a primary treatment for adults with mdd. we will also measure change in the inflammatory biomarker c-reactive protein for an examination of the effects of depression treatment on this measure.

Eligibility criteria:
inclusion criteria: * english speaking * able to give informed consent * dsm-iv (scid) diagnosis of major depression * ham-d17 score ≥ 17 * good general medical health; no active significant uncontrolled medical illness * free of antidepressant medication for a minimum of 6 weeks before study entry * not "needle phobic" by self report exclusion criteria: * axis i and ii disorders including: bipolar, obsessive compulsive disorder, psychosis, or antisocial or borderline personality disorder with suicidal risk * major depression with psychotic features * actively suicidal * recent (6 month) history of substance or alcohol dependence (dsm-iv criteria) * meditation practice once or more per week * yoga practice more than twice per week at study entry * mini mental status exam score \< 25or history of neurologic illness

Keywords: mindfulness-based cognitive therapy depression treatment mindfulness meditation psychotherapy
dermasensor study of primary care physician use of elastic-scattering spectroscopy (ess) on skin lesions suggestive of skin cancer

Conditions: Skin Cancer

Summary: the purpose of this study is to evaluate the clinical validity of the proprietary dermasensor elastic scattering spectroscopy (ess) device and classifier algorithm to support assessment of skin lesions suggestive of melanoma, basal cell carcinoma, and/or squamous cell carcinoma in the primary care setting.

a prospective, single-arm, blinded, multicenter study conducted at 22 investigational sites in the united states and australia. eighteen sites located in the us and four sites located in australia.

Eligibility criteria:
inclusion criteria: 1. men or women of any ethnic group aged 22 and older 2. primary skin lesion suggestive of melanoma, basal cell carcinoma, and/or squamous cell carcinoma that requires biopsy to assess risk of malignancy 3. patient is willing and able to read, understand and sign the informed consent form (icf) exclusion criteria: 1. lesion \ 15mm in diameter 2. lesion surface not accessible (e.g. inside ears, under nails, completely covered by a crust or scale) 3. lesion on area of crust, psoriasis, eczema or similar skin condition 4. lesion has erosion and/or ulceration with no area \>2.5mm intact 5. lesion has foreign matter (e.g. tattoo, splinter, dermoscopy oils, or other medicated or non-medicated topical solutions) 6. lesion in which the device tip cannot be placed entirely within the border of the targeted area 7. lesion located on acral skin (e.g. sole or palms) 8. lesion located within 1 cm of the eye 9. lesion on or adjacent to scars, areas previously biopsied, or areas subjected to any past surgical intervention 10. lesion located on mucosal surfaces (e.g. genitals, lips) 11. lesion located on acute sunburn 12. six (6) or more lesions suggestive of melanoma, basal cell carcinoma, and/or squamous cell carcinoma requiring biopsy to assess risk of malignancy 13. dementia or other neurologic, physical or psychological limitation that would prevent the patient from signing informed consent

Keywords: melanoma basal cell carcinoma squamous cell carcinoma elastic scattering spectroscopy
collagen-based filler for trapeziometacarpal osteoarthritis

Conditions: Trapeziometacarpal Osteoarthritis

Summary: introduction. trapeziometacarpal osteoarthritis (tmc oa) is a degenerative condition characterized by pain, stiffness, and reduced hand function, significantly impairing daily activities. non-surgical management strategies include activity modifications, nonsteroidal anti-inflammatory drugs (nsaids), splinting, and corticosteroid injections. when conservative treatments fail, surgical options are considered. the eaton-littler classification stratifies tmc oa into four stages based on radiographic joint degeneration. chondrofiller liquid®, a cell-free collagen scaffold composed of native type i collagen and chondrostimulating factors, facilitates cartilage regeneration by creating a protective environment for chondrocyte proliferation. it is indicated for treating cartilage lesions up to 3 cm². a prior study demonstrated its efficacy in alleviating pain, improving grip strength (jamar test and pinch test), and enhancing patient-reported outcome measures (proms) using the disabilities of the arm, shoulder, and hand (dash) score. aims. this study aims to extend the follow-up to 24 months to evaluate the long-term sustainability of clinical improvements following chondrofiller liquid® infiltration. materials and methods. a total of 40 patients from the initial study were enrolled and categorized into two severity groups based on the eaton-littler classification. clinical evaluations were conducted at 18 months post-infiltration (t1) using the numeric rating scale (nrs) and dash score. a subsequent assessment at 24 months (t2) included the jamar test, pinch test, nrs, and dash score. an additional cohort of 51 patients underwent infiltration with a mean follow-up of 14 months, including 9 patients previously treated in the preliminary study.


Eligibility criteria:
inclusion criteria: * patients with rhizarthrosis diagnosed on x-rays performed in the last year; * patients aged \> 18 years; * enrollment in the study through informed consent; exclusion criteria: * patients who have undergone cortisone and/or hyaluronic acid infiltrations in the last 6 months; * patients following trauma involving the atm; * patients with underlying rheumatological diseases; * patients under 18 years of age * ongoing pregnancy; * patients affected by metabolic disorders (e.g. diabetes)