Kornimate/medical-research-clean huggingface dataset:
management of occlusal dentinal caries in deciduous molars

Conditions: Caries, Dental

Summary: this study evaluated and compared the efficacy of no caries removal and sealing with a well-adapted and crimped stainless steel crown verses selective caries removal upto soft dentin and upto firm dentin in healing and/or preventing progression of moderate to deep occlusal dentinal caries.

dental caries is a complex multifactorial disease and is one of the most prevalent diseases throughout history. it can cost a lot of money to treat and causes infection, pain and the loss of teeth. choices for managing a carious lesion cover a spectrum of options-from complete surgical excision, where no part of the visible carious tissue is left in the tooth before a restoration is placed, to the opposite extreme, where none of the carious tissue is removed and noninvasive methods are used to prevent progression of the lesion. thus, this study compared efficacy of no caries removal and sealing the entire lesion verses partial selective caries removal to soft and to firm dentin in healing and/or preventing progression of moderate to deep occlusal dentinal caries in previously unrestored teeth by clinical and radiographic analysis in 4-7 year old children.

Eligibility criteria:
inclusion criteria: * children in the age group of 4 - 7 years * previously untreated first and second mandibular deciduous molars with moderate to deep occlusal caries i.e. caries involving middle 1/3rd to pulpal 1/3rd of dentin * no root resorption or physiologic resorption not exceeding 2/3rd of the root length * children having positive and definitely positive behavior exclusion criteria: * children with special health care needs * children with dental crowding limiting the child's ability to maintain oral hygiene * teeth with clinical and/or radiological signs or symptoms of non- vitality * teeth with clinical and radiological signs or symptoms of irreversible pulpitis or dental abscess (pain, mobility, tenderness to percussion, draining sinus, pulp polyp, furcal or periapical radiolucency, root resorption) * mobility of the tooth * pathologic root resorption * physiologic root resorption exceeding 2/3rd of root length in preoperative x-ray

Keywords: no caries removal partial caries removal upto soft dentin partial caries removal upto firm dentin
cholangioscopy in primary sclerosing cholangitis (psc)

Conditions: Primary Sclerosing Cholangitis (PSC)

Summary: to demonstrate the clinical utility of the addition of per oral cholangioscopy (pocs) to standard endoscopic retrograde cholangiopancreatography (ercp) with brushing cytology for diagnosis and early detection of cholangiocarcinoma in patients diagnosed with primary sclerosing cholangitis (psc).

the primary objective of this study is to demonstrate the clinical utility of the addition of per oral cholangioscopy (pocs) to standard ercp with brushing cytology for diagnosis and early detection of cholangiocarcinoma in patients diagnosed with primary sclerosing cholangitis (psc).

Eligibility criteria:
inclusion criteria: 1. confirmed diagnosis of psc 2. clinical indication for ercp per local standard of practice, such as suspicion of potential malignancy based on worsening cholestatic values or clinical presentation (such as itching, cholangitis) or new biliary stricture on trans-abdominal imaging (mri/mrcp, us or ct) or suspicious cytology 3. diameter of bile ducts deemed sufficient to accommodate the cholangioscopy system based on imaging performed prior to scheduled ercp 4. written informed consent from patient to participate in the study, including compliance with study procedures. exclusion criteria: 1. contraindication for an ercp or pocs 2. history of liver transplantation 3. mass/metastasis extrinsic to the bile duct identifiable on diagnostic imaging 4. history of iatrogenic bile duct trauma, including biliary surgery within 6 months of enrollment 5. inr \> 1.5 or platelets count \< 50,000 6. age \< 18 years 7. pregnant women or women trying to become pregnant

Keywords: per oral cholangioscopy psc cholangiocarcinoma primary sclerosing cholangitis ercp
natural killer (nk) cells following bariatric surgery

Conditions: Natural Killer Cell Deficiency, Familial Isolated

Summary: this study will determine the role of the nk cells before and after bariatric surgery. the investigators selected patients with nafld. a fibroscan evaluation will be assessed as a new modality to evaluate liver fibrosis.

all morbidly obese patients who are candidates for a bariatric procedure in the investigators institution who has a fatty liver in their routine preoperative us will undergo a fibroscan to assess the degree of liver fibrosis preoperatively in addition to a blood sample that will be withdrawn from those participants to isolate the nk cells and to assess their activities by the assessment of the active form of nk cells (cd107a) using the spectrometry (facs) analysis. the investigators will also collect other clinical data including comorbidities (hypertension, diabetes mellitus and hyperlipidemia) in addition to the following routine blood test( complete blood count, creatinine, urea, international normalized ratio, liver function test, hba1c, cholesterol, hdl, ldl, triglycerides, vitamin d, vitamin b12, potassium, sodium, albumin, bilirubin, c- reactive protein, iron, ferritin and transferrin). all of the above mentioned tests including the nk cells and the fibroscan will be examined for all participants in 3, 6, 12 months postoperatively.

Eligibility criteria:
inclusion criteria: * age from 18-65 * body mass index above 30 with comorbidity or above 35 with or without comorbidity * evidence of hepatic fibrosis in routine preoperative us exclusion criteria: * patient with known other liver disease such as autoimmune or alcoholic hepatitis * patient that take hepatotoxic medication or hormonal treatment * active alcohol abuse above 20 gram per day * drug abuse * patient refusal * pregnancy
action of probiotics on the microbiota and intestinal permeability in children with neurodevelopmental disorders and their influence on the improvement of language and learning

Conditions: Neurodevelopmental Disorders

Summary: the study included boys and girls with neurodevelopmental disorders between the ages of 3 and 16 years, belonging to two educational centers in madrid, attended by children with this type of disorder. both centers have similar characteristics in terms of the type of feeding and management of the children attending them. the study will be randomized, so that probiotics will be administered to some children and placebos to others; and blinded, so that neither the patient nor his family will know whether probiotic or placebo is administered. the aim of this project is to study the results obtained on microbiota, intestinal permeability, language, behavior and learning of a probiotic combination that will be administered to children in several educational centers that care for children with neurodevelopmental disorders for 5 months.

the trial was conducted in 4 stages: * probiotic development, which will be randomized, so that some children will receive the probiotic and others placebos, and blinded, so that neither the children nor their relatives will know whether they take placebo or probiotic. * initial survey to rule out digestive symptoms and resolve possible doubts. data will be collected on type of housing, location, number of family members, and others. collection of fecal samples prior to the administration of the probiotic, to carry out a microbiota and intestinal permeability study. * administration of the probiotic preparation or placebo to the subjects for 5 months. monitoring will be done within each center and in the middle of the treatment the doctors will make a face-to-face visit to see the children. * in the last phase a new online visit is made where a complete clinical history and a survey to rule out digestive symptomatology are evaluated. a neurocognitive evaluation is also done using the sena behavioral test. new fecal samples are collected for a microbiota and intestinal permeability study following the same procedure as in the second stage.

Eligibility criteria:
inclusion criteria: * children with neurodevelopmental disorders between 3 and 16 years old * similar characteristics in terms of type of food exclusion criteria: * digestive symptomatology: gastroesophageal reflux, abdominal pain, flatulence, dysphagia, abdominal distension or constipation

Keywords: neurodevelopment probiotics microbiota learning children
corticosteroids therapy and pneumocystis jirovecii pneumonia (pcp)

Conditions: Pneumocystis Carinii Pneumonia

Summary: to explore the effects of corticosteroid therapy on pulmonary fibrosis and potentially pneumothorax in patients with mild pcp (po2 \>70mmhg) combined with the standard of care treatment of antibiotic therapy.

although the development of highly active anti-retroviral therapy has substantially reduced the incidence of pneumocystis jirovecii pneumonia (pcp) among hiv-infected individuals, pcp remains one of the most common presenting opportunistic infection among this population. the use of adjunctive corticosteroids in the treatment of patients with moderate to severe pcp has resulted in a significant improvement in the development of respiratory failure and mortality. past studies have demonstrated no clinical benefit in patients with mild disease (po2\>75 torr on room air). this may have been due to the fact that few patients with mild disease develop either respiratory failure or die during the course of the acute illness so that a statistical difference could not be demonstrated. however, considering parameters other than mortality, there is some evidence to suggest that patients with high po2 concentrations benefit from adjunctive corticosteroids. pcp is associated with the development of pulmonary fibrosis and this can have significant consequences. pathological studies have shown the development of interstitial fibrosis late in the course of acute illness. studies have documented the presence of diffuse interstitial pneumonitis five months after the onset of acute illness. therefore, patients with pcp infection, regardless of their po2 level on presentation may benefit from corticosteroid therapy. the current standard of care therapy for patients with pcp does not involve the addition of corticosteroids to standard antibiotics in those patients with po2\>70 mmhg. this study propose to conduct a randomized, prospective, un-blinded clinical trial to explore the effects of corticosteroid therapy on pulmonary fibrosis in patients with mild pcp who are admitted to the george washington university hospital.

Eligibility criteria:
inclusion criteria: * hiv infection, * hospital admission for suspected pcp, * confirmatory test for pcp (bronchoscopy with bronchoalveolar lavage), po2\>70 mmhg or po2\<70 mmhg while breathing room air, * 18 years or older exclusion criteria: * contraindications to corticosteroid therapy, * unable and or unwilling to perform pfts or to return for follow-up evaluations, * underlying lung disease such as emphysema, untreated active tuberculosis, uncontrolled diabetes (fasting glucose \> 250 mg/dl, * uncontrolled hypertension (160/95 mmhg), * pregnancy

Keywords: pneumocystis jirovecii pneumonia corticosteroid therapy hiv pneumonia pulmonary function testing antibiotics prednisone human immunodeficiency virus cd4 cd8 viral load bactrim pentamidine atovaquone primaquine/clindamycin trimethoprim/dapsone
association between cytochromep4501a2 and cytochromep4502e1 gene polymorphisms and metabolism of theophylline

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the aim of this study is to determine whether common cyp1a2 and cyp2e1 gene polymorphisms effect metabolism of theophylline in chronic obstructive pulmonary disease patients.


Eligibility criteria:
inclusion criteria: * aged 18-75 years,copd patients, male or female; * regularly visiting our hospital; * taking a sustained-release preparation of theophylline continuously for at least 2 weeks exclusion criteria: * patients with renal or hepatic dysfunction; * patients with congestive heart failure; * patients with hypothyroidism or hyperthyroidism; * patients currently taking drugs likely to affect theophylline metabolism or who had taken such drugs in the preceding week; * patients with extreme obesity * patients with very severe chronic obstructive pulmonary disease(copd)

Keywords: copd theophylline cyp1a2 cyp2e1
drug use investigation for paxil tablet

Conditions: Mental Disorders

Summary: this post-marketing surveillance study is designed to detect adverse events (particularly clinically significant adverse drug reactions) occurring in clinical settings and to examine factors likely to affect the safety and efficacy of paroxetine.


Eligibility criteria:
inclusion criteria: * patients with depression/depressed state or panic disorder exclusion criteria: * patients who had been taking paxil since before the start of the survey * patients with hypersensitivity to paroxetine * patients taking monoamine oxidase inhibitors (maois) or within 2 weeks of stopping treatment with maois * concomitant use in patients taking pimozide
exploration of dyspnea at non-high brain natriuretic peptide (bnp)

Conditions: Heart Failure With Preserved Ejection Fraction

Summary: patients with unexplained stress dyspnea ( ≥ stage 2 nyha), no significant underlying lung disease, with an ejection fraction \> 50%, normal resting filling pressures, ntprobnp \< 220 pg/ml in \< 75 years, and \< 450 pg/ml in ≥ 75 years will be studied with stress echocardiography and cardiometabolic stress test (vo2). these patients may have abnormal adaptation during exercise, suggesting that chronic symptoms may be related to a heart failure with preserved ejection fraction (hfpef). more accurate and earlier diagnosis of hfpef using stress echocardiography and vo2 may better manage stress dyspnea in patients and prevent progression of hfpef. a clinical assessment will be offered to people with unexplained stress dyspnea. the procedures and products used in this study are usually used as part of hfpef's diagnostic strategy. during this assessment, carried out on an outpatient basis, an anamnesis collection, a cardiovascular clinical examination, an evaluation of dyspnea by the nyha functional class and by 2 questionnaires, an electrocardiogram will be carried out, a 6-minute walk test, a biological blood test, a trans thoracic rest and stress cardiac ultrasound, respiratory functional tests (with diffusion capacity of lung for carbon monoxide (dlco) and blood gas), and a metabolic stress test. a follow-up at 1 and 2 years is planned (visit, sampling and resting echocardiography).


Eligibility criteria:
inclusion criteria: * patient over 40 years of age, and under 80 years of age with unexplained effort dyspnea, able to pedal. * echocardiographic ejection fraction \> 50% * ntprobnp \< 220 pg/ml in \< 75 years, and \< 450 pg/ml in ≥ 75 years exclusion criteria: * patient with coronary, valve, hypertrophic, hypertensive, infiltrative, constrictive, or rhythmic, significant and/or progressive heart disease. bmi \> 35 kg/m². * unstable patient (systolic blood pressure \ 100 bpm) or clinically congested (edema of the lower limbs, crackling in the lungs). * patient with pulmonary function testing (efr) showing significant respiratory disease (fev1/ vital capacity (cv) max \< 0.7, total lung capacities (cpt)\< lin) * chronic renal failure with creatinine clearance \< 30 ml/min (mdrd) or dialysis * patient with anemia (hb \< 12 g/dl) * patient with hypo or hyperthyroidism on thyreostimulating hormone (tsh) value * patient under justice safeguard measure or guardianship

Keywords: heart failure dyspnea stress test
treatment of nonalcoholic fatty liver disease in children (tonic)

Conditions: Fatty Liver

Summary: the purpose of this study is to determine if therapeutic modification of insulin resistance or oxidative stress leads to improvement in serum or histologic indicators of liver injury or quality of life.


Eligibility criteria:
* age 8-17 years at first screening visit * histologic evidence of nonalcoholic fatty liver disease (nafld) - biopsy cannot be older than 6 months as of randomization * alt level \>60 u/l at time of screening and on one previous occasion determined at least one month but no greater than 6 months prior to screening alt * consent

Keywords: non alcoholic fatty liver disease
relationship between eit and respiratory status in very preterm infants

Conditions: Chronic Lung Disease of Prematurity; Bronchopulmonary Dysplasia; Premature Lungs

Summary: electrical impedance tomography (eit) is a non-invasive imaging technique that can measure lung function in real time. this study will follow premature infants to see if eit can help predict which infants will be successful in weaning off respiratory support by 32-33 weeks gestational age. if successful, eit could be used to develop new guidelines for respiratory support in premature infants.


Eligibility criteria:
inclusion criteria: * infants admitted to the umass memorial medical center (ummmc) neonatal intensive care unit (nicu) * born between 25+0- and 29+6-weeks of gestation exclusion criteria: * infants with major congenital anomalies * infants with severe hemodynamic instability

Keywords: electrical impedance tomography (eit) prematurity pulmonary function testing noninvasive ventilation continuous positive airway pressure (cpap) transcutaneous co2 monitor (tcom)
blood transfusions in preterm infants

Conditions: Red Blood Cells; Preterm

Summary: a cross sectional study to assess the effect of blood transfusions on the outcome of preterm infants

this is a cross sectional study carried on preterm infants who are staying in the hospital as "growers"; to gain weight. we will assess blood transfusion received by these preterm infants in details.

Eligibility criteria:
inclusion criteria: * grower preterm infants exclusion criteria: * severe illness, hypovolemic shock, hypoxia, oxygen therapy, surgical intervention
multiple chronic conditions for older adults

Conditions: Chronic Disease

Summary: multiple chronic conditions are common and expensive among patients aged ≥65 and are associated with lower quality of life, poorer response to treatment, worse medical and psychiatric outcomes, higher mortality, and higher costs of care. the primary purpose of this study is to conduct a randomized clinical trial (rct) to examine the effects of eldertree --a web-based intervention--on health outcomes and healthcare use among older adults with several chronic health conditions, such as diabetes, high blood pressure, high cholesterol, copd, bmi over 30, congestive heart failure, chronic kidney disease, arrhythmia/atrial fibrillation, chronic pain, arthritis. the investigator's hypothesis is that patients assigned to tau+eldertree will have better quality of life and fewer primary care visits than those assigned to tau+internet.


Eligibility criteria:
inclusion criteria: 1. are ≥65 years old 2. have been treated in the university of wisconsin health clinics for at least the previous 18 months with no plans to leave during the study period 3. have 3 or more of the following chronic conditions: hypertension, hyperlipidemia, diabetes, arthritis, bmi over 30, chronic kidney disease, congestive heart failure, arrhythmia/atrial fibrillation, pulmonary heart disease or pulmonary vascular disease, chronic pain, copd 4. report no current psychotic disorder that would prevent participation 5. have no acute medical problem requiring immediate hospitalization 6. be able to read and sign the consent form in english 7. have no known terminal illness 8. be willing to share health-related study data and * systolic and diastolic bp * weight * bmi * hdl/ldl * hba1c * pain score * lung function * health care utilization: number of er visits, urgent care visits, primary care visits and specialty care visits 9. allow researchers to share information with their primary care physician

Keywords: hypertension, hyperlipidemia, diabetes, arthritis, obesity
rapid movement therapy for stroke rehabilitation

Conditions: Stroke

Summary: stroke survivors have higher risks of falling compared to other healthy non-stroke adults. stroke patients' balance can be trained by kinect-based training that enable user friendly and interactive training.


Eligibility criteria:
inclusion criteria: 1. have single stroke with onset \>1 year, 2. have unilateral paresis, 3. are 50 years of age or older, 4. able to stand without aid for at least 15min, 5. have moderate level of motor impairment in the affective upper limb, i.e. 15≤ fugl-meyer assessment for upper-extremity(fma-ue) ≤ 45, 6. have some level of deficit in balance control, i.e. berg balance scale(bbs)\< 52/56, 7. have a minimum snellen visual acuity of 20/40 with/without spectacles, 8. have a minimum mini-mental-status-examination score of 22/30, and 9. have to be able to follow the training procedures. exclusion criteria: 1. enrolled in other rehabilitation program in the study duration, 2. have other neurological conditions in addition to stroke (e.g. parkinson's disease), 3. have unstable cardiovascular disease (e.g. history of heart disease, or poorly controlled hypertension, i.e. blood pressure \>160mmhg/100mmhg), or 4. have other serious diseases or conditions (e.g. osteoporosis, recent joint replacement surgery, amputation) that preclude them from participating in the study.
suspected cases of carbon monoxide poisoning in the ed

Conditions: Carbon Monoxide Poisoning

Summary: the purpose of this study is to collect non-invasive observational data in suspected or known carbon monoxide poisoning.


Eligibility criteria:
inclusion criteria: * known or suspected carbon monoxide poisoning exclusion criteria: * less than 18 years of age
pelvic floor dysfunction and quality of life in patient undergoing gynecological surgery

Conditions: Pelvic Floor Dysfunction

Summary: the purpose of the study is to assess the pelvic floor dysfunction and quality of life in patient undergoing gynecological surgery.common gynecological surgeries done for prolapse, fibroids, and cervical abnormality and also for gynecological cancer.early physiotherapy after gynecological surgery improves recovery by managing pain, restoring movement, and strengthening muscles, especially the pelvic floor.conservative treatments like pelvic floor muscle exercises, biofeedback, and lifestyle changes can help with pelvic symptoms, including urinary incontinence and mild to moderate prolapse.

this is a randomized control trial to see the effects of pelvic floor training on pelvic floor dysfunction and quality of life in patient undergoing gynecological surgery. females meeting the inclusion and exclusion criteria will be divided into three groups by convenient sampling technique. a sample size of 48 females with 16 females in each group. group a will be treated four weeks pre and 8 weeks post op pelvic floor training exercises, group b will be treated only 8 weeks post op pelvic floor training exercises and group c will receive basic post op nursing care. group a and b will have three treatment sessions per week assessment will be done at 0 week (1month prior to surgery), 1 day before surgery, 2nd , 4th, 6th and 8th week after surgery. females will be screened by pelvic organ distress inventory (pfdi-20) and pelvic floor impact questionnaire (pfiq-7).

Eligibility criteria:
inclusion criteria: * women age:40 -60yrs * undergoing vaginal or laparoscopic-assisted vaginal surgery for either pop repair (primary or recurrent), and/or hysterectomy exclusion criteria: * emergency surgery * chronic illness * unstable mental state

Keywords: pelvic floor training , gynecological surgery, quality of life, strength of pelvic floor muscle