Kornimate/medical-research-clean huggingface dataset:
accuracy and precision of the true vie i3 continuous glucose monitoring system: an open label, multi-center trial

Conditions: Diabetes Mellitus

Summary: the purpose of the investigation is to evaluate the performance of the i3 cgm according to the fda's special controls for icgm.

participants will attend a screening visit, 4 clinic visits with frequent sampling testing (fst) at the beginning, 2 in the middle, and end of the i3 cgm sensor wear, and a visit for removal of the i3 cgm. participants will wear 3 i3 cgm devices for up to 15 days and be instructed to continue their normal daily activities and manage their glucose as usual between in clinic fst per routine care. participants will not have access to the i3 cgm data for the management of their blood glucose between clinic visits and will continue their usual care including cgm, if they are cgm users. at the clinic fst visits venous blood samples will be drawn from an intravenous cannula for fst for up to 10 hours for plasma glucose determination. during the clinic visits the investigative site staff will determine the participants' insulin doses and meals and may induce both hypoglycemia and hyperglycemia of up to an hour duration.

Eligibility criteria:
inclusion criteria: * 1. patients with t1dm or t2dm diagnosed for at least 6 months. 2. individual is 18-80 years old, inclusive, at the time of screening. 3. must be and have been in stable treatment regimen for at least 1 month with a multiple daily insulin dosing regimen (at least two insulin doses with meals daily) or csii using at least two bolus doses a day with meals, irrespective of delivery device(s). exclusion criteria: * 1. history of skin adhesive tolerance issues in the area of sensor placement. 2. hba1c \> 9%. 3. insulin meal dosing based on fixed dose regimens. 4. absence of established correction factor for high glucose. 5. hematocrit below 10% under the lower limit of the normal range. 6. body mass index \< 18.5 kg/m2. 7. inadequate intravenous access on arms. 8. participant has had a hypoglycemic seizure within the past 6 months prior to enrollment. 9. participant has had an episode of diabetic ketoacidosis (dka) within the past 6 months prior to enrollment. 10. participant has a history of a seizure disorder. 11. pregnancy, planned pregnancy within the study period, or unwillingness to use reliable contraception during the study period. 12. planned mri, ct scan or diathermia procedure for the duration of the study.
comparison of three different puncture techniques in ebus-tbna

Conditions: Lung Cancer; Sarcoidosis; Tuberculosis

Summary: the purpose of this study was to compare the accuracy and sensitivity of slow-pull capillary technique, traditional suction aspiration and non negative pressure puncture in the diagnosis of mediastinal and/or hilar lymph node enlargement by ultrasound bronchoscopic lymph node biopsy.

ebus-tbna has been widely used in the diagnosis of diseases involving lung hilar and mediastinal lymph node enlargement.but different puncture methods are still controversial. research shows that there was no significant difference in sample adequacy, diagnostic specificity and accuracy between the no negative pressure aspiration and traditional negative pressure aspiration technique.slow-pull capillary technique is a relatively new operating method of endoscopic ultrasound guided fine needle biopsy in recent years. at present, this technology is widely used in pancreatic space occupying lesions. compared with the traditional negative pressure aspiration method, our previous retrospective study found that the slow-pull capillary technique can improve the diagnostic accuracy of patients. therefore, the purpose of this study is to prospectively and randomly compare the advantages and disadvantages of three puncture methods in ebus-tbna.

Eligibility criteria:
inclusion criteria: * age 18-80years * chest computed tomography showing hilar or mediastinal lymph node enlargement * no contraindications for bronchoscopy * signed informed consent provided by the patient * disease needs to be diagnosed through the ebus-tbna exclusion criteria: * severe coagulation dysfunction * severe cardiopulmonary dysfunction * acute asthma attack or massive haemoptysis * poor general condition * physical weakness without tolerance for anaesthesia or allergy to narcotic drug * disease can be diagnosed by other less invasive methods (such as skin or peripheral superficial lymph node biopsy)
glowtest covid-19 antigen home test kit usability study

Conditions: COVID-19

Summary: the purpose of this study is to evaluate the usability of the glowtest covid-19 antigen home test in home use.

the arion bio glowtest covid-19 antigen home test is a lateral flow immunoassay intended for the qualitative detection of sars-cov-2 nucleocapsid protein antigens from individuals with or without symptoms or other epidemiological reasons to suspect a covid-19 infection. the test is intended for non-prescription home use with self collected direct anterior nares swab samples from individuals ages 14 years and older or adult collected anterior nares swab samples from individuals aged 2 to 13.

Eligibility criteria:
inclusion criteria: 1. an institutional review board (irb) approved informed consent/assent is signed and dated prior to any study-related activities. 2. male and female subjects 2 years of age and older. 3. subject is willing to provide a self-collected nasal swab sample. (if under the age of 14, the sample will be collected by an adult.) 4. subject agrees to complete all aspects of the study. exclusion criteria: 1. subject has a visual impairment that cannot be restored with glasses or contact lenses. 2. subject has prior medical or laboratory training. 3. subject uses home diagnostics, e.g., glucose meters, hiv tests. 4. subject has prior experience with home covid test kits
evaluating potential risk of choking by laryngeal ultrasound in patients with acute stroke

Conditions: Acute Stroke

Summary: the investigators evaluate the vocal cord movement in patients with acute stroke by ultrasound. the occurrence of choking or aspiration pneumonia will be collected in one year after the index stroke.

post-stroke dysphagia is a common complication for the stroke patient. it may cause aspiration, poor nutrition or even pneumonia; thus, it is crucial for the physicians to evaluate the swallowing function of the stroke patients. however, the evaluation methods nowadays still have some limitations. water swallowing test is one of the well-known methods, but the test itself would put the patients at risk of aspiration. furthermore, in order to increase the sensitivity of the water swallowing test, the amount of the water should also be increased; as a consequence, the risk of aspiration will also increase. fiberoptic endoscopic evaluation of the swallowing and videofluoroscopy have limitations of invasiveness. the laryngeal ultrasound to evaluate the vocal cord movement can be an alternative method, having the characteristics of non-invasiveness and repeat evaluation. the investigators aim to evaluate the vocal cord movement in patients with acute stroke by ultrasound. the occurrence of choking or aspiration pneumonia will be collected in one year after the index stroke.

Eligibility criteria:
inclusion criteria: * acute stroke (in one month) patients exclusion criteria: * patients with stroke occurring more than one month ago
study on the use of cinacalcet in phosphocalcic context.

Conditions: Hyperparathyroidism, Secondary; Hyperparathyroidism, Primary

Summary: currently, the indications used for ma (marketing authorization) cinacalcet in france are hyperparathyroidism (hyperpth) in adults, whether primary (for patients in whom parathyroidectomy is theoretically indicated but in whom it is contraindicated or not is not clinically appropriate) or secondary to a chronic kidney disease, and parathyroid carcinomas. in pediatric patients, data on its use are restricted due to its recent marketing authorization (2017) and limited to dialysis patients suffering from secondary hyperpth. nevertheless, some patients with phosphocalcic pathologies without renal insufficiency must be treated off-label by cinacalcet in the presence of severe hyperpth, without any other chronic treatment available to date. the objective of this study is therefore to evaluate the use in france of cinacalcet in phosphocalcic pathologies without renal insufficiency, in order to obtain efficacy and safety data in order to improve our knowledge on the management of these orphan diseases.


Eligibility criteria:
inclusion criteria: * patients with phosphocalcic pathology without end-stage renal failure * patients followed in one of the hospitals of the centers of reference and competence of the diseases of the metabolism of calcium and phosphate * for children under 18: patient and parent (s) / parent having been informed of the study and having expressed their on-opposition * for adults: patient / legal guardian of the patient under guardianship having been informed of the study and expressing his or her non opposition exclusion criteria: * patient suffering from parathyroid cancer, * patient suffering from primary hyperpth in whom parathyroidectomy would theoretically be indicated but contraindicated or clinically inappropriate, * patient suffering from hyperpth secondary to end-stage renal failure * no social security support

Keywords: hyperparathyroidism pathology phosphocalcic
guided and unguided therapeutic game to improve emotional abilities of students

Conditions: Emotional Stress

Summary: the aim of the study is to investigate the efficiency of a therapeutic online game, with and without coaching, in training emotional abilities of students.

the study is a randomized control trial with three groups. we will perform measurements before the intervention, after the intervention and at one month follow-up. participants will be students and will be randomized into three groups using a randomization program. the first group will be the gaming with coaching group, the second group will bw the gaming without coaching group and the third group will be the control group. measurements will be performed before receiving the game, after the intervention and at one month follow-up. we will measure depression, anxiety, stress and well-being as primary outcomes, solution focus orientation as secondary outcome and rational and irrational cognitions as mechanism outcome. all questionnaires will be completed online in a google form. the intervention will consist of the rethink game. rethink is a therapeutic game developed and tested to improve emotional abilities in children. participants in our study will test two levels of rethink as well as a trial version of the game. each level of the game is focused on a component: * level 1: recognition of emotions * level 2: relaxation and mindfulness * level 3: rational and irrational cognitions * level 4:changing the cognitions * level 5: problem-solving * level 6: positive emotions * level 7: summary of previous aqusitions

Eligibility criteria:
inclusion criteria: * being a student in a public or private university from romania exclusion criteria: * not being enrolled as a student in a university from romania

Keywords: emotional skills emotional abilities stress relaxation
evaluation of the prevalence of bppv and longterm effects of its therapy using the rotundum device in retirement homes

Conditions: Benign Paroxysmal Positional Vertigo

Summary: benign paroxysmal positional vertigo (bppv) is one of the most common types of vertigo, especially in elderly. therefore the investigators have set the goal to evaluate the prevalence of bppv and its therapy using the rotundum device in elderly living in retirement homes. furthermore the investigators use a questionnaire to evaluate possible predictive signs to improve the diagnosis of this disease.


Eligibility criteria:
inclusion criteria: * lives in retirement home/has vertigo/has signed the informed consent exclusion criteria: * severe heart failure * untreated cardiac arrythmia * severe autonomic dysregulation * untreated epilepsy * untreated cervical vertebral body fracture * inability to follow the test * weight over 150kg or under 40kg * height below 140cm or over 200cm * bedridden * already participated this study * participant is connected to the study team
observational study of an automatic detection of patients at risk of chronic postoperative pain ("alerte douleur")

Conditions: Pain, Postoperative

Summary: following surgery, some but not all patients develop persistent (or chronic) postoperative pain cpsp. several risk factors for this persistent pain have been confirmed in previous studies, but neither surgeons nor anesthesiologists have or take the time to systematically screen patients for this risk. however, hospital information systems often contain the data already, entered during preoperative consultations (e.g. chronic opioid medication) or obtained during the postoperative period (e.g. pain scores). here the investigators test an automatic detection algorithm which alerts the analgesia team when a patient at risk of cpsp is or has been operated.

the primary aim of the study is to confirm that the sensitivity of the automatic alert is at least 80%, i.e. that 80% of patients with the primary outcome had an automatic alert. the secondary aim of the study is to develop an algorithm (combination of risk factors) with which the specificity of the alert can be improved.

Eligibility criteria:
inclusion criteria: * 18 years of age * elective surgery * perioperative use of the hospital information system * surgery of the following types: endoprosthesis of the knee or shoulder, amputation other than toe or finger, spinal surgery, cardio-thoracic thoracotomy, laparotomy, inguinal hernia repair, breast surgery exclusion criteria: * inability to read and understand the consent form or the questionnaires * emergency surgery * having already participated in the study for another surgery
turkish version of modified child dental anxiety scale

Conditions: Behavior; Child, Only; Anxiety, Dental

Summary: background: the faces version of the modified child dental anxiety scale (mcdasf) is less time consuming and an easy to understand tool for measuring dental anxiety. the aim of this study was to develop the turkish version of mcdasf and to analyze its validity and reliability.

the internal consistency reliability was determined by calculating cronbach's alpha (n=300). intraclass correlation coefficients (iccs) were calculated for test-retest reliability (n=67). construct validity was determined by comparing with the venham picture test (vpt). the factor structure was examined using exploratory factor analysis (efa). confirmatory factor analysis (cfa) was used for the dimensionality. the cut-off points of the turkish version of mcdasf were plotted using a receiver operating characteristic (roc) curve.

Eligibility criteria:
inclusion criteria: * aged between 6-12 years, intellectual sufficiency to complete the questionnaire, and voluntariness to take part in the study. also, only children whose parents were willing to participate were included exclusion criteria: * children who had mental or physical disorders, cooperation problems or dental pain were excluded from the study.
ultrasound guided erector spinae plane block vs intrathecal morphine

Conditions: Post Operative Pain

Summary: total abdominal hysterectomy (tah) is a major surgical procedure after which significant post-operative pain and discomfort are anticipated. abdominal field blocks have been followed for many years and extensively used for pain management following abdominal surgeries such as laparotomies and appendicectomies. erector spinae plane block (espb)-first recently described for the treatment of thoracic neuropathic pain, is a peri-paravertebral regional anesthesia technique that has since been reported as an effective technique for prevention of postoperative pain in various surgeries. intrathecal opioid administration is an attractive analgesic technique since the opioid is injected directly into the cerebrospinal fluid, close to the structures of the central nervous system where the opioid acts.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) 25 to 35kg/m². * american society of anesthesiologist (asa) physical status i or ii. exclusion criteria: * patient's refusal * altered mental status * known allergy to study drugs (bupivacaine or morphine) * local infection at site of puncture. * known case with any pulmonary disease * known case with obstructive sleep apnea (osa) * coagulopathy and /or thrombocytopenia * chronic pain * severe hepatic or kidney impairment
regionalized pediatric emergency care in rural pennsylvania

Conditions: Emergencies

Summary: the overall goal of this project is to develop and evaluate an organized, regional system of pediatric emergency care in rural western pennsylvania.

the outreach project will develop, implement and evaluate an organized system of regional pediatric emergency care in rural western pennsylvania. toward that end the investigators have developed three broad goals: (1) to define the key barriers and potential solutions to regionalized pediatric emergency care through community stakeholder engagement; (2) to implement a regionalized system of pediatric emergency care using education, community outreach and telemedicine; and (3) evaluate the impact of the system on health care access and outcomes for rural children. the investigators will implement the intervention in a sample of rural hospitals in pennsylvania using a staggered roll-out design, and compare outcomes of children seen in these hospitals to similar matched hospitals in the state, using pennsylvania state medicaid data to evaluate the impact of the intervention.

Eligibility criteria:
inclusion criteria: * pennsylvania * medicaid beneficiary * less than or equal to 18 years of age exclusion criteria: * none

Keywords: pediatrics emergency medical services emergency treatment telemedicine
professional quality of life in german psychiatrists

Conditions: Mental Disorder; Burnout, Caregiver; Burnout, Professional

Summary: the purpose of this study is to assess professional quality of life in german psychiatrists working with patients with mental disorders.

the purpose of this study is to assess professional quality of life, which includes compassion satisfaction, burnout and secondary traumatization in psychiatrists, working with patients with mental disorders, in germany.

Eligibility criteria:
inclusion criteria: * psychiatrits (physician with specialization in psychiatry or currently in specialization for psychiatry) * currently working with patients with mental disorders * at least 18 years old * sufficient german skills for answering the questionnaire exclusion criteria: none

Keywords: professional quality of life compassion satisfaction burnout psychiatrists mental disorders mental health
titanium-prepared platelet rich fibrin versus connective tissue graft for management of type-2 gingival recession

Conditions: Gingival Recession

Summary: the aim of the study is to evaluate the effectiveness of using titanium prepared platelet rich fibrin with coronally advanced flap in the treatment of type-2 cairo gingival recession.


Eligibility criteria:
inclusion criteria: * gingival recession type 2 according to cairo et al (2011). * adequate amount of attached gingiva (ag) (2 mm≤ ag). * good oral hygiene (full mouth bleeding score and o'leary index less than ≤10 % after complete phase i therapy) * clinically thick gingival biotype (1mm \&lt; gingival thickness). * anterior esthetic zone. exclusion criteria: * patients with gingival recession types 1 and 3 according to cairo et al. * inadequate amount of attached gingiva (ag \&lt; 2 mm). * uncooperative patients. * smoking more than 10 cigarettes per day. * patients with known systemic conditions or taking medications that may affect soft tissue healing. * pregnant and lactating women. * patients with parafunctional habits.
d-serine in schizophrenia

Conditions: Schizophrenia

Summary: this study will assess the effects of d-serine adjuvant treatment to the ongoing pharmacological treatment of schizophrenia patients that are resistant to treatments.


Eligibility criteria:
inclusion criteria: * dsm-5 schizophrenia criteria, able and willing to give informed consent, and comply to study procedure, adequate contraception, post-menopausal or abstinent, panss total score equal or greater than 70, score of 4 or greater on two psychotic items exclusion criteria: * clinically significant, uncontrollable or unstable medical condition, mental retardation or severe organic brain syndrome, significant risk of suicide or violent behavior
impact of hiv and its treatment on reverse cholesterol transport

Conditions: HIV Infections

Summary: to investigate the effect of treatment of hiv infection with highly active antiretroviral therapy on individual steps of reverse cholesterol transport, endothelial function and intima-media thickness in hiv patients.


Eligibility criteria:
inclusion criteria: * male patients with hiv infection (3 groups of 50 patients each) * hiv infected patients, naïve to arv therapy and not likely to need to commence therapy for the duration of follow-up (12 months) * hiv-infected patients, pi naïve, initiating therapy with pi-containing haart (arv naïve or nnrti experienced changing to pi regimen) * hiv-infected patients naïve to arv therapy, initiating nnrti-containing regimen exclusion criteria * treatment with any form of lipid lowering drugs, including fish oils. * body mass index greater than 27.

Keywords: treatment naive hiv
intermittent oral tube on feeding amount

Conditions: Stroke

Summary: the goal of this clinical trial is to compare the differences in feeding amount and nutritional status between ischemic stroke patients using intermittent oro-esophageal tube and nasogastric tube. patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. on this basis, the observation group will use intermittent oro esophageal tube for enteral nutrition support, while the control group will use nasogastric tube. researchers will compare changes in daily intake and nutritional status of two groups of patients before and after the study to see if intermittent oro-esophageal tube can improve the feeding amount and nutritional status between ischemic stroke patients compared to nasogastric tube

the study will last 15 days for each participant. the goal of this clinical trial is to compare the differences in feeding amount and nutritional status between ischemic stroke patients using intermittent oro-esophageal tube and nasogastric tube. patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. on this basis, the observation group will use intermittent oro esophageal tube for enteral nutrition support, while the control group will use nasogastric tube. researchers will compare changes in daily intake and nutritional status of two groups of patients before and after the study to see if intermittent oro-esophageal tube can improve the feeding amount and nutritional status between ischemic stroke patients compared to nasogastric tube

Eligibility criteria:
inclusion criteria: * age\>18 years. * meeting the diagnostic criteria for ischemic stroke . * dysphagia confirmed by videofluoroscopic swallowing study. * clear consciousness. * no history of prior stroke. * stable vital signs. exclusion criteria: * dysphagia that might be caused by other diseases that might cause dysphagia, such as head and neck tumors, traumatic brain injury, myasthenia gravis, etc. * complicated with severe liver and kidney failure, tumors, or hematological disorders. * simultaneously in need to undergo other therapy that might affect the outcomes of this study. * pregnant or nursing females.