Kornimate/medical-research-clean huggingface dataset:
nk cells treatment for covid-19

Conditions: Novel Coronavirus Pneumonia

Summary: since december 2019, acute respiratory disease due to 2019 novel coronavirus (2019-ncov) emerged in wuhan city and rapidly spread throughout china. there is no confirmed antivirus therapy for 2019-ncov infection. natural killer (nk) cells are innate lymphocytes that may serve as useful effectors against danger infection. the purpose of this clinical investigation is to evaluate the safety and efficiency of nk cells in combination with standard therapy for pneumonia patients infected with 2019-ncov.


Eligibility criteria:
inclusion criteria: * 1. male or female, aged at 18 years-65 years old * 2. pneumonia that is judged by chest radiograph or computed tomography * 3. laboratory confirmation of ncp infection by reverse-transcription polymerase chain reaction(rt-pcr) from any diagnostic sampling source exclusion criteria: * 1. pregnancy or breastfeeding * 2. known hiv, hbv or hcv infection * 3. patients with malignant tumor, other serious systemic diseases and psychosis * 4. patients who are participating in other clinical trials * 5. inability to provide informed consent or to comply with test requirements
postoperative management for hnscc based on pathological response of induction chemotherapy and immunotherapy

Conditions: Head and Neck Cancer

Summary: to develop postoperative stratification treatment for patients who have received induction chemotherapy and immunotherapy in locally advanced head and neck cancers. risk stratification is based on clinical characteristics and pathological responses. in order to achieve no inferior survival rate and a lower treatment-related toxicity rate than the standard treatment.

induction chemotherapy combined with immunotherapy has shown promising efficacy in the treatment of patients with locally advanced head and neck cancers. however, how to choose a proper postoperative treatment remains unknown. eligibility patients were assigned to two arms, each divided into three groups: observation, immunotherapy maintenance, and radiotherapy (50 gy dose) plus immunotherapy maintenance group for low-risk arm; radiotherapy (50 gy or 60gy dose) plus immunotherapy maintenance groups, concurrent chemotherapy plus immunotherapy maintenance group for a high-risk arm. disease-free survival, overall survival, and treatment-related toxicity would be calculated to evaluate the efficacy of treatments.

Eligibility criteria:
inclusion criteria: 1. the subjects are not limited by gender, age from 18 to 75 years old; 2. histopathologically confirmed squamous cell carcinoma of the head and neck cancer; 3. locally advanced squamous cell carcinoma diagnosed as t3-4 or n+ stage according to ajcc 8th edition staging; 4. ecog score 0-1; 5. without distant metastasis; 6. received induction chemotherapy plus immunotherapy, followed by surgery 7. the expected survival is expected to be no less than 6 months. 8. no contraindications to chemotherapy, immunotherapy, and radiotherapy; exclusion criteria: 1. past malignancies history (except for stage i non-melanoma skin cancer or cervical carcinoma in situ) 2. received any systemic anti-tumor therapy for target lesions before induction chemotherapy and immunotherapy; 3. previously experienced head and neck radiation therapy; 4. subjects who have used corticosteroids (\>10 mg/day prednisone or other equivalent hormones) or other immunosuppressive agents for systemic treatment within 1 month before enrollment. in the absence of active autoimmune disease, inhaled or topical corticosteroids and adrenal hormone replacement therapy at therapeutic doses of prednisone ≤10 mg/day are permitted; 5. patients with pleural effusion, pericardial effusion or ascites that need to be drained with clinical symptoms, or who have received serous cavity effusion drainage for the purpose of treatment within 2 weeks before enrollment; 6. severe comorbidities including myocardial infarction, arrhythmia, cerebral vascular disease, ulceration disease, mental disease and uncontrolled diabetes

Keywords: postoperative radiotherapy induction immunotherapy and chemotherapy
the impact of an online stress management program on in vitro fertilization (ivf) outcome

Conditions: Infertility

Summary: the goal of this study is to determine the impact of an online stress management program, which combines stress reduction and prevention strategies with personal care products/rituals which have relaxation properties, on pregnancy rates and psychological distress in women undergoing ivf for the first time.

the relationship between stress and infertility has remained a subject of controversy for many years. recent research indicates that stress has a strong negative impact on pregnancy rates in women undergoing in vitro fertilization (ivf). in addition, stress is the most common reason given by women who voluntarily terminate treatment. in a recent study, women who participated in a group mind/body treatment program had higher pregnancy rates than control subjects. the impact of an online stress management program has never been studied in the infertile population. an online intervention would be far more accessible for many infertility patients.

Eligibility criteria:
inclusion criteria: * female boston ivf patients * day three fsh 12 or below * day three estradiol 80 pg/ml or below * able to read, understand and sign the informed consent in english * using own eggs (not egg donor) * willing and able to comply with study requirements * must be well versed in using a personal computer and the internet and must have access to an internet-connected computer seven days per week exclusion criteria: * prescription antipsychotic medication * previous diagnosis of borderline or narcissistic personality disorder * previous or concurrent participation in a mind/body group

Keywords: ivf stress management
comparison of proton pump inhibitor and h2 receptor blocker on prevention of bleeding from iatrogenic ulcer after endoscopic submucosal dissection for gastric neoplasms: a prospective randomized controlled trial

Conditions: Delayed Bleeding

Summary: after endoscopic submucosal dissection(esd) of early gastric cancer, conventional proton pump(ppi) inhibitors and h2 receptor antagonists have a controversial effect on preventing bleeding from artificial ulcers. the aim of this study was to investigate whether a stronger acid suppression (high dose ppi) more effectively prevents bleeding after esd


Eligibility criteria:
inclusion criteria: * the patients who agreed informed consent * gastric adenoma or early gastric cancer which is eligible for conventional esd indication exclusion criteria: * recent drug history of ppi, h2 rector antagonist, bismuth and antibiotics within 4 weeks * recent drug history of anticoagulant or antiplatelet agent within 7 days * s/p subtotal gastrectomy * recurred gastric adenoma or cancer * pregnant or breast feeding patients
prehab prior to stem cell transplantation in multiple myeloma

Conditions: Multiple Myeloma; Exercise; Prehabilitation

Summary: the primary purpose of this study is to see if individuals with multiple myeloma are able and interested in taking part in a tailored exercise program while undergoing their chemotherapy prior to a stem cell transplant. we also hope to learn if this type of program, along with a flexible delivery format (in-person and virtual), helps in maintaining or improving physical fitness, muscle mass and strength, and quality of life during chemotherapy.

motivate is a multi-methods feasibility randomized trial. we will recruit a minimum of 30 individuals with multiple myeloma who are undergoing chemotherapy prior to a stem cell transplant. the study will be conducted in two phases: phase i: feasibility study the aim of this phase is to determine the feasibility and preliminary effectiveness of a 10-week exercise intervention compared to physical activity counseling alone. phase ii: qualitative study the aim of this phase is to evaluate the acceptability of the healthy eating active living (heal-me) app design, program delivery/design, and perceived effectiveness of the intervention at the level of the participant.

Eligibility criteria:
inclusion criteria: 1. have a diagnosis of multiple myeloma 2. be transplant eligible 3. be undergoing chemotherapy prior to an autologous stem cell transplant as part of their cancer treatment 4. be an alberta resident 5. be ≥18 years of age 6. be able to read and understand english. exclusion criteria: 1. their disease status/comorbidities preclude exercise testing or participation 2. they are unable to commit to the 10-week exercise program and/or testing sessions at the cancer rehabilitation clinic at the university of alberta 3. they do not have regular access to the internet and/or an electronic device in the home.
does local morphine add to local anesthetics in serratus anterior plane block has a system analgesic effect?

Conditions: Postoperative Complications

Summary: the investigators aim is to investigate and explore the effect 10 mg morphine added to local anesthetics in serratus anterior plane block for post mastectomy pain management after modified radical mastectomy in patients with breast cancer with assessment of its serum level if it will be absorbed systemically or not?


Eligibility criteria:
inclusion criteria: * (asa) class i-ii * body weight of 50 - 90 kg exclusion criteria: * a history of bleeding diathesis, * relevant drug allergy, opioid dependence, * sepsis, prior surgery in the supraclavicular, infraclavicular or axillary regions, alcohol or drug abuse , patients with advanced cardiovascular disease
hair cortisol and symptoms in children with psychopathology during cbt

Conditions: Child Behavior Problem

Summary: this study aims to examine the relationship between hair cortisol concentration and behavior and sleep disturbance symptoms in children with psychiatric disorders. it also investigates potential changes in hair cortisol and symptomatology after group-based cognitive behavior therapy. furthermore, the study explores the effects of any alterations in hair cortisol concentration levels on potential behavior and sleep disturbance symptom change over the course of the study.


Eligibility criteria:
inclusion criteria: * symptoms of anxiety or depression * deficiencies in emotional and behavioral skills impairing functioning * sufficient social and cognitive skills to participate in group work. exclusion criteria: * excessive physical aggression * excessive physical restlessness * severity of psychiatric symptoms requiring individual psychotherapy (e.g., acute suicidality).

Keywords: children group cognitive behavioral therapy hair cortisol concentration internalizing symptoms externalizing symptoms sleep disturbance symptoms
the effect of web-based mindfulness-based stress reduction program on pregnant women

Conditions: Anxiety; Pregnancy Related

Summary: pregnancy is a period in which physiological and psychological changes are experienced and discomforts related to these changes are observed, and comfort is affected for the pregnant. however, fetal health concern refers to the concern of the expectant mother about the health of her developing fetus. mindfulness is a non-judgmental and accepting focus of one's attention on what is happening right now. a total of 96 pregnant women (48 experimental, 48 control) are planned to be included in the study. data will be collected with the "personal description form", "prenatal comfort scale (pcs)" and "fetal health anxiety inventory (fhai)". in the study, a stress reduction program (mbsr) based on mindfulness will be applied by the researcher to the pregnant women in the experimental group.

women experience intense physiological, psychological and social changes during pregnancy and postpartum period. pregnancy and postpartum period can be a difficult process for some women due to biological and environmental factors. mindfulness-based approaches have been used in solving both physical and mental problems in pregnant women and very positive results have been obtained. the aim of this study, which is carried out to determine the effect of mindfulness on prenatal comfort and fetal anxiety levels in pregnant women, is aimed at creating intervention programs compatible with the antenatal period and contributing to the improvement of pregnancy outcomes. a total of 96 pregnant women (48 experimental, 48 control) are planned to be included in the study. data will be collected with the "personal description form", "prenatal comfort scale (pcs)" and "fetal health anxiety inventory (fhai)". in the study, a stress reduction program (mbsr) based on mindfulness will be applied by the researcher to the pregnant women in the

Eligibility criteria:
inclusion criteria: * not having any diagnosed psychiatric disease, * literate, * using a smart phone, * with internet access * having a headset accessory for phone calls, * pregnant women who voluntarily agreed to participate in the study exclusion criteria: * filling in the questionnaire form incompletely, * pregnant women with communication barriers and mental disabilities

Keywords: prenatal comfort mbsr
the role of vitamin d, a, and beta carotene in tuberculosis patients with vitamin d receptor gene polymorphism

Conditions: Tuberculosis

Summary: recent studies showed that vitamin d and a has an effect in improving sputum conversion in tuberculosis. this study aims to find out the effect of vitamin d 1000 iu and a 6000 iu supplementation on tuberculosis patients with vitamin d receptor gene polymorphism, who live in north sumatera, indonesia. this study is a randomized control clinical trial, with 48 tuberculosis patients with vitamin d receptor gene polymorphism which are taqi and foki participating, divided into two groups, each with 24 participants, which are treatment group (i) which receives nutritional counseling, vitamin d 1000 iu, vitamin a 6000 iu, and control group (c) which only receives nutritional counseling for 28 days. patients who participated was found to be heterozygous with taqi (t\>c) or foki (c\>t) genotype variants.

recent studies showed that vitamin d and a has an effect in improving sputum conversion in tuberculosis. this study aims to find out the effect of vitamin d 1000 iu and a 6000 iu supplementation on tuberculosis patients with vitamin d receptor gene polymorphism, who live in north sumatera, indonesia. this study is a randomized control clinical trial, with 48 tuberculosis patients with vitamin d receptor gene polymorphism which are taqi and foki participating, divided into two groups, each with 24 participants, which are treatment group (i) which receives nutritional counseling, vitamin d 1000 iu, vitamin a 6000 iu, and control group (c) which only receives nutritional counseling for 28 days. patients who participated was found to be heterozygous with taqi (t\>c) or foki (c\>t) genotype variants. the result of this study showed that at the start, serum 25(oh)d levels in group i were lower compared to group c (19.746.59 ng/ml vs 25.21±7.57 ng/ml). group i showed significant correlation between vitamin d level categories with sputum conversion (mean: standard deviation= 2.25±0.68 weeks). supplementation of vitamin d 1000 iu provides an accelerated sputum conversion in tuberculosis patients with vitamin d receptor gene polymorphism.

Eligibility criteria:
inclusion criteria: * the inclusion criteria are males or females, which have new case lung tuberculosis infection with acid fast bacilli (afb) result (+), aged 18-60 years, heterozygote genotype test on one of the genes taqi and foki, willing to participate in the study and complete the informed consent. exclusion criteria: * the exclusion criteria are pregnant, found to have comorbidities such as diabetes mellitus or human immunodeficiency virus (+), and tuberculosis on category ii.

Keywords: 25(oh)d serum calcium counseling foki retinol taqi
effect of footcore exercises on navicular drop and plantar pressure distribution in asymptomatic individual with flatfoot

Conditions: Flatfoot

Summary: pes planus is a medical condition in which arch of the foot is flattened, causing the entire sole of the foot to contact the floor. for those with flat feet, footcore exercises might be an effective non-invasive therapy. footcore exercises aim to strengthen the intrinsic foot muscles that maintain the foot arch, enhance foot function and reduce the risk of injury in persons with flatfoot.

a pilot, random research with 10 participants was undertaken. two groups, experimental group and control group, were randomly selected among the subjects. participant completed the informed consent form before the navicular drop test and harris mat was used to measure the foot pressure. footcore exercises and conventional therapy was given for four weeks ,twice a day for 6 days. while the control group just received conventional treatment, the experimental group combined footcore exercise with it. the data will be analyzed using spss 26.0 software.

Eligibility criteria:
inclusion criteria: 1. individuals having flat feet. 2. those with a height difference of ≥ 10 mm during the navicular drop test. 3. no history of foot or ankle surgery. exclusion criteria: 1. any lower limb injury 2. healing fracture of lower limb33 3. any neuromuscular disorder 25 4. recent surgery 5. any open wound.

Keywords: footcore, harris mat, plantar pressure.
effect of binaural beats on level of anxiety and toleration in patients undergoing upper gastrointestinal endoscopy without sedation

Conditions: Patient Satisfaction; Anxiety State; Tolerance

Summary: to investigate the anxiolytic effects of binaural beat-embedded audio in patients undergoing sedation-free upper gastrointestinal endoscopy

the study was conducted with the participation of 96 patients who were referred for endoscopy for various reasons. data were collected by two researchers. patients between the ages of 18-70 who had scheduled upper gastrointestinal endoscopy appointments were included in the study, regardless of gender and underlying diseases. patients who had undergone endoscopic procedures before, were using medication for anxiety and panic disorders, required urgent endoscopic intervention, had advanced dementia, had hearing problems, had anatomical or inflammatory disorders in the external ear canals, and those who did not want to listen to music for 15 minutes before the procedure were not included in the study.

Eligibility criteria:
inclusion criteria: - between 18-70 years old who had scheduled upper gastrointestinal endoscopy appointments exclusion criteria: * anxiety and panic disorders * urgent endoscopic intervention * advanced dementia * hearing problems * anatomical or inflammatory disorders in the external ear canals
patients experiences of rehabilitation before and after reverse shoulder arthroplasty

Conditions: Osteoarthritis of the Shoulder

Summary: reverse shoulder arthroplasty is a complex surgical procedure requiring thorough rehabilitation, and its frequency is increasing globally. while previous studies have quantitatively examined postoperative outcomes, such as pain levels and shoulder function, no research has yet explored patients' subjective experiences of the rehabilitation process before and after surgery. purpose of the study was to explore patients' experiences of undergoing reverse shoulder arthroplasty and the associated rehabilitation process.

surgery with total shoulder arthroplasty is a procedure that has increased in number in the last twenty years, and it is the third most common prosthetic surgery in the world after hip and knee. there are two types of shoulder arthroplasty, anatomical and reverse. when the rotator cuff is severely impaired or completely dysfunctional, a reverse shoulder prosthesis is used, in which the anatomical positions of the ball and socket are reversed. there are thus several factors that the treating physiotherapist needs to take into account. research on reverse shoulder arthroplasty has primarily focused on evaluations using quantitative measures. qualitative research from the patient's perspective can provide a deeper understanding of their expectations and experiences, offering insights that complement and fill the gaps left by quantitative research. gaining insight into patients' experiences would be valuable for physiotherapists working with this group, as it may help identify areas for improvement in care to better meet patients' needs.

Eligibility criteria:
inclusion criteria: the inclusion criteria encompassed patients who had undergone elective surgery involving reverse shoulder arthroplasty in the västra götaland region who demonstrated proficiency in both spoken and written swedish. exclusion criteria: exclusion criteria applied to cases where the study leader had served as the patient's physiotherapist, the presence of neurological disorders, or the occurrence of surgical complications, such as infection or fracture.

Keywords: reverse shoulder arthroplasty, qualitative research, physiotherapy, experiences
the role of ck18f in predicting graft-versus-host disease (gvhd)

Conditions: Allo-SCT

Summary: prospective, within-subject controlled study on multiple subject groups to evaluate the meaning of ck18-fragments in the diagnosis, biological activity and prognosis of graft-versus-host disease (gvhd). groups consist of patients scheduled for allogenic stem cell transplantation (allo-sct) (group a) and healthy voluntary blood donors (group b).

given the difficulties in assessing diagnosis, severity and biological activity of gvhd by clinical means only, objective parameters for specific gvhd assessment are highly desirable. criteria for appropriate gvhd biomarkers have recently been defined, thereby stating that suitable validated markers for monitoring of chronic gvhd are still lacking. ck18-f is the first marker that mirrors the pathogenetic endpoint of gvhd i.e. gvhd-induced apoptotic activity in critical epithelial organs (bowel and liver). it represents a new class of gvhd markers which are complementary to the previously recognized immune activation parameters and might thereby be valuable for establishing serological signatures diagnostic for gvhd. this marker may allow distinguishing active gvhd from irreversible end organ damage and other clinical conditions commonly observed after transplant. the aim of this study is to evaluate if diagnostic and therapeutic decisions in the clinical management of hepato-intestinal gvhd may be based on the measurement of ck18-f levels.

Eligibility criteria:
inclusion criteria: group a: * admission for allogenic sct * age \>= 18 years * ability of subject to understand character and individual consequences of this clinical trial * written informed consent group b: * healthy male of female * age \>= 18 years * ability of subject to understand character and individual consequences of this clinical trial * written informed consent exclusion criteria: group a: no specific exclusion criteria group b: * prolonged bleeding, hemorrhagic diathesis or other indications for clotting disorders in the medical history * prolonged or intense menses in females * any other current medical condition or previous disease which in the opinion of investigator may influence subject safety or interfere with the study objective * intake of any study drug

Keywords: allo-sct, gvhd, ck18-f