Kornimate/medical-research-clean huggingface dataset:
quality of life after rectal cancer surgery

Conditions: Rectal Cancer; Quality of Life

Summary: following colorectal surgery, many patients face a combination of physical and emotional problems for a long period of time. symptoms such as pain, fatigue, and disturbed bowel and sexual function, as well as problems in social and role functioning, inevitably affect the patients' well-being. therefore, evaluation of the self-reported quality of life (qol) is becoming increasingly important in clinical trials. the investigators aimed to compare long term health related life quality (hrqol) results of laparoscopic approach with open approach in patients with sphincter preserving resections for rectal cancer at a single-center.

this study is planned prospectively. all patients scheduled for operation due to rectal cancer in our clinic between january 2017 and december 2018 will be evaluated for suitability for the study. during the preoperative examination, patients will be informed about the study and their written consent will be obtained. patients will be randomized between open and laparoscopic groups in the ratio 2:1, depending on the type of surgery. clinical data of patients will be analyzed from the hospital database programme. the eortc qlq-c30 and qlq-cr29 questionnaires prepared by the european organization for research and treatment of cancer (eortc) will be used to evaluate the quality of life after the operation. the eortc qlq-c30 questionnaire will be completed by examining the patients' daily observation notes. eortc qlq-cr29 will be completed with face to face interviews in the first year after surgery. in this way, it will be aimed to compare the early and long-term quality of life (hrqol) results of open and laparoscopic approach in patients undergoing surgery for rectal cancer.

Eligibility criteria:
inclusion criteria: * patients who underwent surgery (laparoscopic or open) for rectal cancer in our department. exclusion criteria: * the patients whose all oncological treatments had not been completed at least 6 months ago * the patients with asa iv score * the patients with previous abdominal surgery * the patients who had developed major surgical complications (such as anastomosis leakage, requiring re-laparotomy, evisceration) * the patients who underwent a new abdominal surgery except for stoma closure * the patients with local recurrence or distant metastases * the patients who still had a stoma * the patients who did not want to take part in the study * the patients who missed in the follow-up period

Keywords: rectal cancer surgery life quality questionnaire
analysis of risk in mds over time - comparison of treated vs untreated patients

Conditions: Myelodysplastic Syndromes

Summary: a comparison of treated vs untreated patients with mds with a sample size of approximately 8000 patients in 11 countries.

non-interventional multicentre retrospective study using chart reviews - study was submitted to the ethics committee of city of vienna - due to the design of the study no specific approval necessary. inclusion of mds (all subtypes and risk groups) patients according to who or oligoblastic aml (raeb-t according to fab), untreated and treated during their chronic mds phase the 26 centers of the iwg-pm have provided control data set of untreated, all centers will be asked for contribution of treated patients data will be collected in austria, brazil, czech republic, france, germany, italy, japan, netherlands, spain, uk, usa.

Eligibility criteria:
inclusion criteria: * mds (all subtypes and risk groups) according to who or oligoblastic aml (raeb-t according to fab) patients untreated and treated during their chronic mds phase exclusion criteria: * none

Keywords: mds ipss-r
a home program using multimodal sensory feedback for people with parkinson disease

Conditions: Parkinson Disease

Summary: people with parkinson disease (pwpd) have significant problems with velocity, safety and dual tasking during walking that may be secondary to poor automaticity. sensory functions, especially visual dependence and proprioceptive integration are critical for efficient walking and are often impaired. this home program compares the use of multimodal sensory feedback during stepping and balance exercises in pwpd to a group without the sensory feedback performing the same basic exercises.

parkinson disease impairs motor and sensory functions. automaticity of gait is lost increasing the use of higher center control of walking, leading to cognitive fatigue, slower movement and motor errors. people with parkinson disease (pwpd) improve motor performance when external sensory cues, which bypass the faulty basal ganglia, are used during interventions. enhancing proprioceptive, visual and vestibular cues that are critical for walking has the potential to improve gait and decrease cognitive fatigue by restoring automaticity. this is a single-blinded randomized controlled study with repeated measures to evaluate the effects of a home exercise program with or without the addition of multi-modal sensory feedback (mmsf) in real-time on automaticity of gait and balance. pwpds are randomly assigned to one of 2 home exercise groups. there are two 6 week exercise sessions with a 6 week of no exercises inter-spaced between them. the exercises promote rapid and large movement in stepping activities, balance using self-perturbation through single, leg swings and standing on a compliant surface for sensory re-weighting. people in the experimental group perform the program with real-time with mmsf. participants are to progress exercises in speed and distance as well as performing with eyes closed to improve proprioceptive processing and automaticity.

Eligibility criteria:
inclusion criteria: * medical diagnosis of parkinson disease * a score of 26 or higher on the mini-mental status exam * able to stand from sitting and take 5 steps without assistance * people who have been on the same dosages of medication for pd for 3 weeks or longer exclusion criteria: * participating in an exercise program for less than 3 months * plans to change a current exercise program during the study * changes in medications that affect pd or its sequelea

Keywords: multimodal real-time feedback automaticity gait balance
chinese herb nephropathy epidemiology and association with cyp2d6, cyp2c19, pxr, or mdr1 polymorphism

Conditions: Kidney Diseases

Summary: 1. chinese herb nephropathy (chn), a kind of kidney failure caused by chinese herbs, may be related to the a component called aristolochic acid (aa). 2. aa may form aa-dna adducts and accumulate in the kidney and ureter and cause kidney failure and/or cancer 3. different enzymes have been reported to detoxify plant alkaloids or other components. genes that regulate the production of these metabolic enzymes may affect the chance of chn. 4. by comparing the differences in the polymorphisms of these genes between patient with chn and control, we may find the changes that play a significant genetic factors for chn.


Eligibility criteria:
inclusion criteria: * patient with suspected chinese herb nephropathy, and their family control group match for sex age and geographic area (with or without herabla use)

Keywords: kidney diseases drugs, chinese herbal aristolochic acid polymorphism, genetic
the gastric cancer foundation: a gastric cancer registry

Conditions: Gastric Cancer

Summary: the gastric cancer registry will combine data acquired directly from patients with gastric cancer; with a family history of gastric cancer in a first or second degree relative; or persons with a known germline mutation in their cdh1 (e-cadherin) gene via an online questionnaire with genomic data obtained from saliva, blood and tissue samples. the purpose of this registry is to gain better understanding of the causes of gastric cancer, both environmental and genetic; whether certain genomic data can predict outcomes of treatment and survival.

collect detailed clinical and epidemiological information on eligible patients via an online registry and a detailed patient questionnaire. participants can opt in to contribute a blood or saliva sample and paraffin block samples from a previous gastric surgery.

Eligibility criteria:
inclusion criteria: 1. patients are eligible if they have a histologically proven gastric tumor including gastroesophageal tumors; or they have a family history of gastric cancer in a first or second degree relative; or persons with a known germline mutation in their cdh1 (e-cadherin) gene. 2. 18 years of age or older 3. adequate english proficiency to complete online consent and questionnaire. spanish-language proficiency as an alternative to english-language proficiency. exclusion criteria: 1. under 18 years of age 2. no history of gastric cancer or gastric cancer in a family member or a known germline mutation in their cdh1 gene.

Keywords: quality of life
evaluation of brain activity changes after a behavior change weight loss intervention

Conditions: Obesity; Behavior, Health; Weight Loss

Summary: the aim of this study is to compare brain changes in individuals with overweight or obesity enrolled in either the noom healthy weight program or a matched control. the study objectives (primary and secondary) are to measure brain change reported as erp and eeg data over a 16-week timeframe. additionally, we will explore changes in the default mode network (resting-state asymmetry in eeg measurements), changes in executive functioning, quality of life, mood, and salivary markers as they relate to eeg data.


Eligibility criteria:
inclusion criteria: * each subject must be able to understand and provide informed consent * between the ages 18-60 years * self-report of good health * overweight or obesity (bmi ≥ 25) * able to meet our criteria of adherence to the program * able to attend in-person visit in long island, ny exclusion criteria: * inability or unwillingness to give written informed consent or comply with the study * visual impairment that cannot be corrected with glasses or contact lenses * any indication of drug, alcohol or medicine abuse. * presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient or the quality of the data * presence of a brain injury, psychiatric disorders, seizure disorders, and other neurological conditions * reported eating disorder * currently pregnant or 6 months postpartum * planning to become pregnant within the next 5 months

Keywords: eeg, mhealth, weight loss, cbt, cognitive behavior therapy
shockwave lithotripsy (swl) versus swl and oral dissolution therapy (odt) for paediatrics radiolucent renal stone

Conditions: Pediatric Kidney Disease

Summary: to conduct a rct comparing swl versus combined odt and swl as non-invasive methods for management of paediatrics radiolucent renal stone.


Eligibility criteria:
inclusion criteria: * 1-2.5 cm renal stone * normal serum creatinine * radiolucent stone with hounsfield units less than 400 exclusion criteria: * bleeding diatheses. * patients with a pacemaker. * uncontrolled utis. * severe skeletal malformations. * arterial aneurysm in the vicinity of the stone. * anatomical obstruction distal to the stone.
evaluation of neopterin levels in pre and post-menopausal women with periodontitis following non surgical therapy

Conditions: Periodontitis

Summary: neopterin has been identified as a marker of cellular immune system activation. it is synthesized by macrophages upon stimulation with the cytokine interferon-gamma and is indicative of a pro-inflammatory immune status. neopterin concentration increases with increasing severity of periodontal disease in diverse body fluids like urine, saliva and plasma. hence neopterin can be considered as an important inflammatory marker in periodontal disease as well as other systemic diseases.

at baseline - plasma, urine and saliva samples were collected and analysed for neopterin levels from the pre and post-menopausal women with periodontitis . followed by scaling and root planing done in both the groups. after 3 months again these 3 samples were collected and analysed for post treatment neopterin levels

Eligibility criteria:
inclusion criteria: * moderate to chronic periodontitis * non-smokers * minimum 15 natural teeth present exclusion criteria: * patients on long term steroid medication * with gross oral pathology or tumors * undergoing hormone replacement therapy * not undergone periodontal therapy in past 6 months * under medication in past 6 months * systemic disorders and drugs which influence the periodontium

Keywords: neopterin plasma urine saliva menopause periodontitis
comprehensive yoga program (sky) as adjunct therapy for prostate cancer

Conditions: Prostate Carcinoma

Summary: this randomized pilot trial studies the effect of comprehensive yoga program (sky) in reducing stress, pain, and fatigue, and improving psychological well-being in patients with prostate cancer. sky is one of the most widely used breathing techniques derived from yoga. sky yoga may improve quality of life in patients with prostate cancer.

primary objectives: i. determine any change in pain, fatigue and psychological well-being as a result of sky in prostate cancer (pca) patients. ii. assess changes in some physiological parameters in response to sky in the same subjects, compare these with those from part 1, and assess whether these translate into clinical effects. outline: patients are randomized to 1 of 2 arms. arm i (control group): patients undergo collection of blood, saliva, and hair samples after signing consent (pre-test 1), within 6-8 weeks after pre-test 1 (post-test 1), and within 2-4 months after post-test 1 (post-test 2). patients may receive yoga instruction for 1 week after post-test 2. arm ii (yoga group): patients receive yoga instruction over approximately 3 hours daily for 5 days of week 1 and over 2 hours once a week of weeks 2-13. patients also undergo collection of blood, saliva, and hair samples within 2 months prior to starting yoga instruction, within weeks 2-3, and within weeks 14-15.

Eligibility criteria:
inclusion criteria: * having finished radiotherapy at least two months ago * ability to speak and read english and give informed consent * have an interest in being part of a study to evaluate yoga-derived exercises and eager to practice some kind of relaxation exercise daily for 3 months exclusion criteria: * have a diagnosis of psychiatric illness or other major illness in addition to pca, such as other cancers, uncontrolled hypertension, lung disease, liver disease or heart disease
eylea and lucentis for macular edema in branch retinal vein occlusion

Conditions: Branch Retinal Vein Occlusion with Macular Edema

Summary: comparing time to recurrence of macular edema after an initial loading dose of at least three monthly anti vegf injections (aflibercept or ranibizumab) for macular edema in brvo.

one hundred and ten patients with macular edema (me) secondary to brvo are randomized (1:1) to treatment with intravitreal injections of aflibercept or ranibizumab. an initial loading dose of at least three monthly injections is given in the study eye until the me is resolved. then patients are observed at regular intervals, initially every four weeks until study completion. total follow-up time is nine months from baseline to completion. if me recurs, patients are treated according to a treat-and-extend algorithm. at every visit, visual acuity (va) is measured with an etdrs chart at 4 m. the fundus is examined by indirect ophthalmoscopy and by optical coherence tomography (oct). macular ischemia is evaluated with oct angiography (oct-a), visual field status with computerised perimetry and retinal sensitivity with microperimetry. choroidal thickness is evaluated with enhanced depth imaging (edi) oct. vision related quality of life (qol) with nei vfq25.

Eligibility criteria:
inclusion criteria: * brvo naïve patients, disease duration 1-6 months, bcva 23-73 etdrs letters (20/40-20/320), macula edema with intraretinal cysts and crt \> 300 micrometers (cirrus) exclusion criteria: * brvo with neovascular component, intraocular surgery during the previous 3 months, earlier vitreoretinal surgery, vascular retinopathy of other cause, intraocular infection/inflammation, myocardial infarction och cerebrovascular stroke during the last 3 months.
influence of gaze shift and emotions on symptoms of blepharospasm

Conditions: Pupillary Occlusion

Summary: blepharospasm (beb) is a focal dystonia characterized by forceful, involuntary contractions of the orbicularis oculi muscle. (jankovic et al 1983) patients with beb report task and situation specific modulations of their symptoms. so called "sensory tricks" are actions that minimize symptoms and include concentrating, talking, pulling on the eyelids, blowing air, and applying pressure to the periocular or temple region. (weiner 1984) many patients describe that other tasks/situations are exacerbate their symptoms specifically under bright fluorescent lights and stress. (burke 1984) earlier studies showed that blink patterns differ between beb patients and control during rest, reading and talking. in healthy subjects gaze evoked blinks are a physiologic phenomenon: initiation of gaze shifts evoke a blink, blinks facilitate gaze shifts. (evinger 1994) in healthy subjects emotions and thoughts influence gaze shifts and blink rate. (leal 2008, de genaro 1988) however, little is known about various task and emotion specific influences on symptoms of beb (e.g. expecting a gaze shift might worsen symptoms while driving a car). differences in emotion and gaze related blink patterns between patients and controls will contribute to the understanding of the pathophysiology of beb. this might offer new therapeutic options, e.g. symptom modulation. the investigators hypothesize that blink patterns, measured by duration and frequency of pupillary occlusion differ between patients and control, when performing gaze shifts and emotion related blink patterns, measured by duration and frequency of pupillary occlusion differ between patients and controls. the aim of this pilot trial is to assess differences in gaze evoked and emotion related blink patterns between patients and controls. these differences might contribute to the understanding of the pathophysiology of beb.


Eligibility criteria:
inclusion criteria: patients: * willing to participate * idiopathic blepharospasm * age 18-80 * last botulinum toxin injection \<3months control: * willing to participate * age and sex matched with patients * age18-80 exclusion criteria: patients: * secondary blepharospasm * neurologic comorbidities * other eye disease besides beb * history of neuroleptic medication * use of medications on the study day, that influence eye blinks\& attention * drinking of caffeine or theine containing beverages on the study day patients and control: * intake of psychotropic drugs at day of examination * history of neuroleptic medication * present eye disease * neurologic diseases that influence blinking * use of medications on the study day, that influence eye blinks\& attention * drinking of caffeine or theine containing beverages on the study day
breakfast meal replacement

Conditions: Body Composition, Beneficial; Basal Metabolic Rate; Satiety; Overweight; Obese

Summary: purpose: to evaluate the effects of replacing breakfast with a high protein, high fat, high fiber meal replacement in overweight individuals, on body composition. participants: healthy, overweight and obese individuals (ages 18-45 yrs) with no history of disease. procedures (methods): in a randomized control intervention, subjects will complete 5 different testing sessions (pre-screening, 2 baseline testing sessions, and 2 post testing sessions) as well as an 8 week intervention period. pre-screening will include written informed consent, health history questionnaire, nutrition analysis, and baseline anthropometric measures. baseline testing will be split into two sessions and include measurements of resting metabolic rate (rmr), body composition, blood and saliva hormones, mood, satiety, and health related quality of life questionnaires, and a cardiorespiratory fitness assessment. subjects will be randomly assigned to treatment (8 week supplementation with meal replacement to be taken at breakfast) and control groups (continue normal eating habits) with 4 electronic correspondences throughout the supplementation period. all measures will be repeated in two post-testing sessions.


Eligibility criteria:
inclusion criteria: * healthy, overweight men and pre-menopausal women * participant agrees to maintain usual activity lifestyle * participant has a body mass index of ≥ 28 (men) and ≥25 (women) kg/m2 and/or %body fat of ≥ 25% * participant has provided written and dated informed consent to participate in the study * participant is willing and able to comply with the protocol * participant is apparently healthy and free from disease, as determined by a health history questionnaire (diabetes, heart disease, kidney disease, cancer, thyroid disorder, etc). * participant agrees to abstain from smoking, caffeine, tobacco, and alcohol before testing days * participant has stated a goal of losing weight or improving body composition exclusion criteria: * having a history of medical or surgical events that may significantly affect the study outcome, including cardiovascular disease, metabolic, renal, hepatic, or musculoskeletal disorders (i.e. anything influencing exercise ability). * participant is using, or has used one of the following dietary supplements within 8 weeks prior to enrollment: meal replacement shakes, whey protein, beta-alanine, creatine, beta-hydroxy beta methylbutyrate, carnosine or taurine * participant has lost or gained greater than ten pounds within the previous 3 months * participant is in, or has participated in another clinical trial within 4 weeks prior to enrollment * participant had or currently has a self-identified eating disorder * participant is pregnant or plans to become pregnant during the duration of the study * participant has a known allergy or sensitivity to any ingredient in the test product or placebo (determined from health history questionnaire)
25gr. glucomedics vs 25gr. zusto

Conditions: Diabetes Mellitus

Summary: objective: to compare blood glucose and insulin responses after consumption of 100ml water, sweetened with 25gr zusto® and 100ml water sweetened with 25gr glucomedics® (standard drink)

this is an experimental study enrolling 10 healthy female subjects. the study compares the blood glucose and insulin responses after consumption of 100ml water, sweetened with 25gr zusto® and 100ml water sweetened with 25gr glucomedics® (standard drink). subjects need to be fasted for at least 8 hours before all visits. at visit 1, five women will consume the solution with 25gr zusto®, the other five will have the solution with 25gr glucomedics®. on visit 2, groups will be switched. visit 1 and 2 will be performed within approximately one week interval. both drinks will be identical in amount of water and only be different by the use of 25gr glucomedics® and 25gr zusto®. before intake of the drink, vital signs, weight and bedside blood glucose and baseline blood samples - 15' and 0' for glucose, insulin and c-peptide will be taken at visit 1 and 2. both drinks will be consumed within 5 minutes and time of start and end of intake of zusto® / glucomedics® will be documented. blood samples for glucose, insulin and c-peptide will be taken at 15', 30', 60', 90', 120' and 180' after start of intake 25gr zusto® and 25gr glucomedics®.

Eligibility criteria:
inclusion criteria: * female subjects * age between 30 and 50 years * bmi between 20 and 30 kg/m² exclusion criteria: * no first degree relatives with mellitus type 1 or type 2 * no intake of medication with influence blood glucose levels * pregnant, breast feeding or planning to become pregnant during the study * employer of the investigator or study center with direct involvement in the proposed study or other studies under the direction of the investigator or study center