Kornimate/medical-research-clean huggingface dataset:
peri-capsular nerve group block versus fascia iliaca block for hip arthroplasty

Conditions: Post Operative Pain Management

Summary: in this study, the investigator will examine the efficacy of pericapsular nerve group (peng) block in hip surgeries as a post-operative pain management technique in comparison with fascia iliaca block in hip surgeries

hip fracture is a common orthopedic emergency in the elderly, and it is associated with significant morbidity and mortality.1 surgical reduction and fixation are the definitive treatment in most patients.2 effective perioperative analgesia that minimizes the need for opioids and related adverse effects (such as delirium) is essential in this patient population. regional analgesic techniques, including femoral nerve (fn) block, fascia iliaca block (fib), and 3-in-1 fn block, are popular analgesic strategies, due mainly to their opioid-sparing effects and reduction in opioid-related adverse effects. the effect size of analgesia from these blocks is only moderate, and literature suggests that the obturator nerve (on) is not covered. the anterior hip capsule is innervated by the on, accessory obturator nerve (aon), and fn as reported by previous anatomic studies. the anterior capsule is the most richly innervated section of the joint, suggesting these nerves should be the main targets for hip analgesia. a recent anatomical study by short et al15 confirmed the innervation of the anterior hip by these 3 main nerves but also found that the aon and fn play a greater role in the anterior hip innervation than previously reported. this study also identified the relevant landmarks for those articular branches. the high articular branches from fn and aon are consistently found between the anterior inferior iliac spines (aiis) and the iliopubic eminence (ipe), whereas the on , close to the inferomedial acetabulum. using this information, the investigator developed an ultrasound-guided technique for blockade of these articular branches to the hip, the peng (pericapsular nerve group) block. in this study, the investigator will examine the efficacy of peng block in hip surgeries as a post-operative pain management technique in comparison with fascia iliaca block in hip surgeries

Eligibility criteria:
inclusion criteria: * patients scheduled for hip replacement surgeries e.g. hip hemiarthroplasty, total hip arthroplasty under subarachnoid block (sab) exclusion criteria: * coagulopathy * infection at the injection site * allergy to local anesthetics * severe cardiopulmonary disease (≥asa iv) * diabetic or other neuropathies * patients receiving opioids for chronic analgesic therapy * contraindication to spinal anesthesia * inability to comprehend visual analog scale (vas).
protecting against hiv vaccine misinformation with adolescent girls and young women in south africa

Conditions: Misinformation; HIV Vaccine

Summary: adolescent girls and young women (agyw) between the ages of 15-24 years continue to bear the brunt of human immunodeficiency virus (hiv) infections in south africa despite progress recorded in prevention and treatment programmes. the ongoing susceptibility of young women to hiv infection and the sub-optimal uptake of prevention options such as pre-exposure prophylaxis (prep) that are highly effective creates a need for an hiv vaccine to benefit populations at substantial risk of hiv infection. however, lessons from previous vaccine studies and the recent covid-19 vaccine have highlighted significant barriers to vaccine uptake, such as widespread misinformation and vaccine hesitancy. these challenges threaten the successful implementation of a future hiv vaccine. building on these insights, this study will utilise psychological inoculation theory to develop and evaluate hiv vaccine messages among adolescent girls and young women. primary objective: to compare changes in intentions to receive hiv vaccine following misinformation exposure in groups with and without psychological inoculation and behavioural economics boost. secondary objectives: (1) to compare believability and persuasiveness of misinformation claims and motivational threat associated with misinformation in groups with and without psychological inoculation and behavioral economics boost. (2) to explore subgroup effects by relevant sociodemographic and behavioural factors including hiv risk, prep history, covid-19 vaccine history, general vaccine hesitancy, and information avoidance. the investigators will conduct a three-arm randomized controlled trial of 2-3 inoculation messages that address emerging myths and misinformation about the hiv vaccine in south africa. participants will be randomly assigned to a control group or one of two intervention arms: (1) inoculation message arm, or (2) enhance inoculation message with insights from behavioural economics.


Eligibility criteria:
inclusion criteria: * female * age 18-24 years * self-reported history of sexual activity in the past 12 months * self-reported hiv-negative status or unknown hiv status at enrolment * willing and able to provide written informed consent * able to read and understand english exclusion criteria: * unwilling or unable to provide consent for study participation.

Keywords: prevention: vaccines adolescent girls and young women south africa hiv
the efficacy of ivermectin in larger doses in covid-19 treatment

Conditions: COVID

Summary: efficacy of ivermectin in larger doses in covid-19 treatment

clinical study evaluating the efficacy of ivermectin in higher doses in covid-19 treatment

Eligibility criteria:
inclusion criteria: * patients with covid 19 exclusion criteria: * allergy or side effects to treatment
ultrasound guided fascia iliaca block for pain control after elective hip replacement surgery

Conditions: Arthroplasty, Replacement, Hip; Fascia Iliaca Block

Summary: the purpose of this study is to determine whether ultrasound guided fascia iliaca blocks performed before surgery help to reduce pain after elective total hip replacements.

total hip arthroplasty is associated with moderate to severe pain in the acute postoperative period, which can increase the risk of postoperative complications such as thromboembolism, myocardial ischemia/infarction, pneumonia, poor wound healing, insomnia, and delirium. sensory innervation of the hip joint comes from a combination of peripheral nerves, including femoral, obturator, sciatic, superior gluteal, and nerve for the quadratus femoris muscle. superficial innervation of the skin involved in incision for hip arthroplasty comes from the lateral femoral cutaneous nerve (lfcn). the fascia iliaca block (fib) was originally described in 1989 using a landmark technique. the ultrasound guided fib was introduced in recent years, and has been shown to produce a better quality of block than the landmark technique. it appears to consistently block the femoral and lfcn, while being less successful in achieving consistent obturator blockade. the fib is effective for analgesia for hip fracture injuries in the emergency department. thus far, there has been limited exploration into the potential use of this block as a tool for postoperative analgesia after elective hip arthroplasty. the potential benefits of this regional block, as with other regional techniques, include better analgesia, less opioid use and associated side effects, and an improved overall patient satisfaction with postoperative recovery.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists' (asa) score i, ii or iii * scheduled for elective total hip arthroplasty exclusion criteria: * contraindication to regional anesthesia (allergy to local anesthetic, coagulopathy, infection or malignancy in the area) * neurologic disorder affecting the ability to sense pain * long term opioid use or chronic pain disorder * history of drug or alcohol abuse * patient refusal * pregnancy * revision procedures * general anesthetic * psychiatric or mental conditions that may affect assessment of outcomes

Keywords: arthroplasty, replacement, hip pain, postoperative nerve block anesthesia, regional fascia iliaca block ultrasound guided
long term effect of somatropin in subjects with intrauterine growth retardation

Conditions: Foetal Growth Problem; Small for Gestational Age

Summary: this trial is conducted in europe. the aim of this trial is to assess the safety of long-term growth hormone treatment in growth-retarded children with intrauterine growth retardation (iugr) enrolled in trial ghretard/f/1/f.


Eligibility criteria:
inclusion criteria: * patients born with iugr enrolled in trial ghretard/f/1/f * bone age below 14 years in boys and 12 years in girls exclusion criteria: * bone age above 14 years in boys and 12 years in girls
effects of lateral femoral cutaneous nerve mobilization with and without muscle energy techniques in pregnant females

Conditions: Meralgia Paresthetica

Summary: the rationale of this study is to provide empirical evidence regarding the efficacy and safety of neural mobilization in pregnant women with meralgia paresthetica. by investigating the potential benefits of this intervention, healthcare professionals can make informed decisions about incorporating neural mobilization into the management of this condition during pregnancy. focusing on the impact of neural mobilization and muscle energy techniques on both neuropathic pain and quality of life aligns with a patient-centered approach to care. the goal is not only to reduce symptoms but also to enhance overall well-being and functional capacity

the literature gap of the study is that upto our knowledge, there is little or no evidence found in previous researches on the combined effects of lateral femoral cutaneous nerve mobilization in combination with met in pregnant females. secondly no quantitative measurement as range of motion with goniometer has been yet studied

Eligibility criteria:
inclusion criteria: * age ranges from 18 to 40 years * body mass index ≥25kg/m2. * pregnant females in third trimester diagnosed with myalgia paraesthetica. * multigravida pregnant females * patients will be screened through prone knee bend (pkb) test for femoral nerve compression. * positive pelvic compression test(1) exclusion criteria: * those having other entrapment syndromes or radicular symptoms * motor weakness * having a history or ongoing cancerous proliferation * active infection

Keywords: femoral neuropathy
a study to determine the efficacy and safety of cabergoline for the treatment of patients with rls

Conditions: Restless Legs Syndrome

Summary: the purpose of this study is to evaluate the efficacy and safety of cabergoline compared with levodopa in the treatment of patients with rls.


Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic rls and had all 4 clinical manifestations of rls * moderate to severe symptoms of rls as indicated by an irlssg-rs total score greater than or equal to 10 and a severity at night score of greater than or equal to 4 on an 11-point rls-6 rating scale * no previous treatment for rls or dissatisfaction with their current therapy exclusion criteria: * not available
phase 1 clinical trial to evaluate the safety and anti-tumor activity of ab-201

Conditions: Breast Cancer; Gastric Cancer; Gastroesophageal Junction Adenocarcinoma

Summary: this clinical trial will enroll subjects with her2+ solid tumors and is conducted in two phases, which are phase 1a and phase 1b. the primary objective of phase 1 is to determine the safety and tolerability of ab-201 in subjects with advanced her2+ solid tumors.

this is a phase 1, multicenter study designed to evaluate the safety, tolerability, and efficacy of ab-201 in subjects with advanced her2+ solid tumors (specifically, breast and gastric/gej cancers). the phase 1 will be conducted in two parts, an initial dose escalation stage followed by a dose expansion stage. study participation for each subject begins with up to 28 days (1 month) of screening following written informed consent, then lymphodepletion treatment, followed by ab-201. up to 3 doses of ab-201 may be administered. all subjects will be monitored for a total duration of 18 months of follow up from the first dose administration of ab-201.

Eligibility criteria:
inclusion criteria: * ecog performance status 0 to 1. * histologically confirmed her2 expressed breast or gastric/gej cancer ihc ≥ 2+ within 6 months prior to study entry. * confirmed diagnosis of an advanced/unresectable or metastatic her2+ breast or gastric/gej cancer that is refractory to, or intolerable of standard treatment, or for which no standard treatment is available. * must have received prior cancer therapy: subjects with breast cancer must have received ≥ 3 prior systemic therapies; subjects with gastric/gej cancer must have received ≥ 2 prior systemic therapy(ies); subjects with ihc 3+ or ihc 2+/ish+ cancers must have received previous treatment with a her2-targeting therapy. exclusion criteria: * known past or current malignancy other than inclusion diagnosis. * known clinically significant cardiac disease. * active central nervous system (cns) metastases, or involvement of the cns, unless there is a history of at least 3 months of sustained remission. * unresolved toxicities from prior anticancer therapy. * ongoing uncontrolled systemic infections requiring antibiotic, anti-fungal, or anti-viral therapy. * history of sensitivity or intolerance to cyclophosphamide or fludarabine. * currently pregnant or lactating * severe disease progression or health deterioration within 2 weeks prior to lymphodepletion regimen.
the relative prevalence and severity of autonomic nervous system dysfunction

Conditions: Cardiovascular Autonomic Neuropathy; Diabetic Autonomic Neuropathy; Autonomic Dysfunction

Summary: the purpose of this study is to measure the prevalence and severity of cardiac autonomic neuropathy (can), diabetic autonomic neuropathy (dan) which in non-diabetics is termed advanced nervous system (ans) dysfunction, and autonomic dysfunction as well as the overall sympathovagal balance (sb) in the cefh population of diabetic patients versus non-diabetic patients undergoing elective vitreoretinal surgery.

the purpose of this study is to measure the prevalence and severity of cardiac autonomic neuropathy (can), diabetic autonomic neuropathy (dan) which in non-diabetics is termed advanced nervous system (ans) dysfunction, and autonomic dysfunction as well as the overall sympathovagal balance (sb) in the cefh population of diabetic patients versus non-diabetic patients undergoing elective vitreoretinal surgery.

Eligibility criteria:
inclusion criteria: * type i and type ii diabetic patients 19 or older who are scheduled for elective surgery to improve vision impaired by diabetic retinopathy * patients scheduled during the same time period without diabetes for retinal surgery will serve as an age and gender matched reference group to undergo the non-invasive ans testing on the day of surgery exclusion criteria: * inability to stand will only do baseline, deep breathing and valsalva portions (a-d) of the testing as described in section 8.1 * patients with syncope on standing will only do portions a-d of the test * inability to cooperate with deep breathing and valsalva * tracheoscopy or otherwise not able to perform a valsalva * not desiring to participate after informed consent * known history of idiopathic dysautonomia * pulmonary difficulties associated with hyperventilation, including acute uri * pacemaker dependent * persistently high intraocular pressure despite treatment * atrial fibrillation * ventricular arrhythmias greater than 10 beats per minute * taking mao inhibitors

Keywords: cardiovascular autonomic neuropathy diabetic autonomic neuropathy autonomic dysfunction
the effect of education and counseling on reducing pain and anxiety in women undergoing hysterosalpingography

Conditions: Women's Health

Summary: this study investigates the effect of education and counseling on anxiety and pain in women undergoing hysterosalpingography as part of the infertility process.

fertility and having a child is a significant experience for most individuals; however, many struggle to achieve pregnancy. infertility is defined as the inability of a couple to conceive after 12 months of regular unprotected sexual intercourse or to carry a pregnancy to term. it is estimated that 10-15 % of the couples globally experience infertility. in turkey, it is estimated that 10-20% of the couples are diagnosed with infertility. in the evaluation of infertile couples, hysterosalpingography (hsg) is a simple, safe, and minimally invasive radiologic procedure to visualize uterine cavity and tubes after contrast enhancement. hsg plays an important diagnostic role in finding the cause of infertility and in deciding the line of management. the aim of this study was to investigate the effect of education and counseling on anxiety and pain before the treatment of women who will have hsg procedure with the diagnosis of infertility. this randomized controlled study was conducted at gulhane training and research hospital, obstetrics and gynecology clinic between may 2016 and january 2017. volunteer women undergoing hsg as part of infertility evaluation have been included. participants were randomly assigned to the intervention or the control group using a computer-generated list. a data collection form including socio-demographic and obstetric characteristics such as age, educational status, duration of infertility, previous pregnancies, births, abortion/curettage numbers, spielberger state anxiety scale and visual analog scale scores was used for each patient. after obtaining written informed consent, the data collection form, spielberger state anxiety scale and vas scoring scale were applied to both groups by face to face interview during the day giving appointment for hsg. immediately after the questionnaires were applied, the nurse gave individual education and counseling were giving by the nurse researcher to intervention group for 30 minutes. participants in the control group received standard care (verbal information about procedure and a short written information about the procedure) and no intervention (education and counseling) was performed.the ibm spss (statistical package for the social sciences) 22.0 package program was used to evaluate the data obtained in the study.

Eligibility criteria:
inclusion criteria: * being diagnosed with infertility * negative the result of the b-hcg testing * being able to understand, read and write in turkish exclusion criteria: * not wanting to be included in the study * not accepting education/counseling * not knowing turkish * having additional diseases related to pelvic pain

Keywords: hysterosalpingography anxiety pain education counseling
pain after cesarean section - a danish multicenter cohort study.

Conditions: Pain; Cesarean Section; Recovery

Summary: pain after a cesarean section is of moderate to severe intensity. a danish multicenter study from 2021 used an obstetric quality of recovery score 24 hours after the cesarean section and found that 45% of 861 patients had experienced very severe pain during recovery. this result was surprisingly high but also unspecific. therefore, the investigators aim to investigate the intensity of pain experienced by patients at specific time intervals after the cesarean section e.g., every 6th hour. additionally, the investigators will examine whether the pain has an impact on important functions for both the patients and the newborns, as well as assess the overall morphine consumption. all danish regions have approved the redcap database as a secure way to collect and store data. redcap can also send encrypted links that can be converted into sms messages sent to the participants' mobile phones at fixed intervals, allowing participants to enter data directly into the secure system. the investigators also aim to feasibility test the system. when a child is delivered by cesarean section, it is an expectation that the mother can take care of herself and the baby a few hours after the surgery. however, severe pain can hinder this. therefore, it is important to investigate whether pain relief for our patients is sufficient. based on response rates and the frequency of outcomes, data from this observational study can support the design of a future national multicenter randomized controlled trial (rct) with a focus on postoperative pain intervention. the incidences of binary outcome measures and standard deviations of continuous outcome measures will support the sample size calculations for our rct.


Eligibility criteria:
inclusion criteria patients who undergo planned cesarean section under spinal anesthesia. patients must be able to answer a danish questionnaire via sms on their phone and provide consent. exclusion criteria: age \< 18 years

Keywords: pain cesarean section recovery redcap
the effect of video streaming with virtual reality before coronary angiography

Conditions: Anxiety; Comfort; Patient Satisfaction

Summary: this study was planned as a randomized controlled experimental study to examine the effects of virtual reality video on anxiety, comfort and patient satisfaction before coronary angiography. data will be collected using the descriptive characteristics questionnaire, state-trait anxiety inventory, early postoperative comfort scale, visual analog scale (vas) for patient satisfaction and pain, vital signs follow-up form and complication follow-up form.

this study was planned as a randomized controlled experimental study to examine the effects of virtual reality video on anxiety, comfort and patient satisfaction before coronary angiography. data will be collected using the descriptive characteristics questionnaire, state-trait anxiety inventory, early postoperative comfort scale, visual analog scale (vas) for patient satisfaction and pain, vital signs follow-up form and complication follow-up form. in addition to the standard practices of the clinic, individuals in the intervention group will be shown a video with virtual reality glasses before entering the angiography procedure. only standard practices of the clinic will be applied to the control group.

Eligibility criteria:
inclusion criteria: * can speak and understand turkish, * over 18 years of age, * no previous angiography procedure, * oriented to place and time, * no psychiatric illness, * not taking any sedative medication, * no vision and hearing problems, * patients who volunteered to participate in the study will be included. exclusion criteria: * patients with any pain or chronic pain prior to coronary angiography, * patients diagnosed with anxiety, * patients with pacemakers, * patients requiring emergency angiography, * patients taking antihistamines and psychiatric drugs, * patients who did not volunteer to participate in the study, * patients taking tranquilizers or pain medication up to 5 hours before the angiography procedure were excluded.