Kornimate/medical-research-clean huggingface dataset:
mindfulness-based stress reduction for gulf war syndrome

Conditions: Persian Gulf Syndrome

Summary: this pilot study is a two arm randomized, controlled clinical trial that evaluated whether a standardized mindfulness-based stress reduction (mbsr) intervention reduces symptoms associated with gulf war syndrome (gws) more effectively than treatment as usual. fifty-five veterans meeting diagnostic criteria for gulf war syndrome were randomized to treatment as usual (tau) or tau plus an 8-week course of course of mbsr. study measures were collected at baseline, immediate post-mbsr, and 6 months post intervention. measures were obtained at equivalent time points for veterans randomized to tau only. following completion of all study activities, veterans randomized to tau only had the opportunity to enroll in mbsr.

a randomized controlled trial with two arms. 55 veterans meeting diagnostic criteria for gulf war syndrome were randomized to standard care or standard care plus an 8-week course of course of mindfulness-based stress reduction (mbsr). study measures were collected at baseline, immediate post-mbsr (within one week of completion of the mbsr class) and 6 months following completion of the mbsr course. measures were obtained at equivalent time points for veterans randomized to usual care only. following completion, veterans randomized to standard care only had the opportunity to enroll in mbsr. this pilot study will whether there is sufficient evidence of benefit to warrant further study, and gathered data that will allow estimation of the sample size needed in future studies. we also obtained measures working memory and attention, in addition to patient self-report measures of symptoms, in order to provide additional assessment of whether mbsr is effective. this project is prerequisite to a larger study.

Eligibility criteria:
inclusion criteria: chart diagnosis of ptsd exclusion criteria: * any past or present psychiatric disorder involving a history of psychosis (schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorder not otherwise specified, etc.) * mania or poorly controlled bipolar * current suicidal or homicidal ideation * prior training in mindfulness meditation * active substance abuse or dependence * must not have had an inpatient admission for psychiatric reasons within the past month

Keywords: persian gulf syndrome pain fatigue attention meditation
effect of flixweed and fig on irritable bowel syndrome with predominant constipation: a single blind randomized clinical trial.

Conditions: Irritable Bowel Syndrome Predominant Constipation

Summary: this study evaluates effect of ficus carica and descurainia sophia on irritable bowel syndrome predominant constipation. one-third of patients will receive ficus carica, another one-third will receive descurainia sophia and remained patients only will follow their regular diet for 4 months.


Eligibility criteria:
inclusion criteria: * patients with irritable bowel syndrome predominant constipation exclusion criteria: * subjects with significant cardiovascular, renal, hepatic, pulmonary, endocrine, metabolic, hematologic disorders, * structural abnormalities of the gastrointestinal tract or * diseases ⁄conditions that affected bowel transition, * surgery, * any prokinetic or laxative drug used during the past month, * any medication that may affect gastrointestinal motility, * other therapeutic dietary advice for ibs, * used fig or flixweed during the last month, * diarrhea, * pregnancy or * breast-feeding
atrial fibrillation: canadian atrial fibrillation evaluation (cafe) study -

Conditions: Atrial Fibrillation

Summary: to evaluate whether atrial fibrillation (af) therapies in guidant pulsar max ii or insignia plus dr have an effect on the occurance of af in patients with no prior history of af

this multi-centre, randomized, cross-over, prospective study will evaluate the occurrence of af with af pacing therapies programmed on (app and vrr) and with af therapies programmed off (app and vrr) in patients with no known prior history of af (all patients have a pacing indication). the occurrence of af as well as time to first event and af burden (frequecy and duration).

Eligibility criteria:
inclusion criteria: * no prior history of af or atrial flutter, primary indication of sss or av block for dual chamber pacemaker, confidentiality agreement signed and dated before implant, available for follow-up at the study centre where they were enrolled at the protocol defined intervals, willing and capable of participating in all testing associated with the study, on stable regime of arrhythmia management drugs. exclusion criteria: * documented history of af or atrial flutter, clinically significant ventricular arrhythmias, \< 18 yrs old, life expectancy \< 1 year or expectation of heart transplantation during the study period, likely to or have received a mechanical tricuspid valve during the study, enrolled in other cardiovascular studies, women who are pregnant, inability or refusal to sign patient confidentiality agreement, inability or refusal to complete the follow-up schedule at the study centre in which they were enrolled, exhibit arrhythmias due to reversible cause eg, digitalis toxicity, hypoxia, transient electrolyte imbalance, acute myocardial infarction or electrocution.
effects of manual therapy versus stretching exercise versus routine physical therapy on work-related pain, among chefs

Conditions: Neck Pain

Summary: the aim of this research is to analyze the effect of mulligan technique versus stretching techniques and versus routine physical therapy on pain, range of motion and functional disability among restaurant chefs presenting with non-specific chronic pain.

a randomized control trail study will be conducted, at riphah international university faisalabad after the approval of synopsis. purposive sampling will be used to enroll the patients. patients will be selected according to the pre-defined inclusion and exclusion criteria. the patients who will meet the inclusion criteria are allocated into three groups. the patients of group a will receive routine physical therapy only. group b will receive manual therapy and routine physical therapy while group c will receive stretching exercises and routine physical therapy. the outcomes will be measured by the neck disability index, visual analogue scale and bubble inclinometer. the data of patients will be recorded pre-treatment and post-treatment. the comparison between pre-treatment and post-treatment data will be done after 3 months. informed consent will be taken from each patient. data entry and analysis will be done with statistical package of social sciences version 20 software.

Eligibility criteria:
inclusion criteria: * for at least 3 months, you've been suffering from neck pain * any neurological problems * for the previous three months, the patient has taken some analgesic drug for neck pain. * rheumatological issues * non-specific neck pain * age 18-60 years exclusion criteria: neck pain due to, * tumors * ankylosing spondylitis * fracture * dislocation * cord compression * insufficiency of the vertebrobasilar artery * osteoprosis * anticoagulant or corticosteroid therapy for a long period of time * pain due to any congenital deformity, inflammation or any infection * carcinoma

Keywords: manual therapy stretching exercises routine physical therapy non specific chronic neck pain restaurant chefs
effect of ehealth coaching program on patient reported outcomes of men with prostate cancer

Conditions: Prostate Carcinoma

Summary: this trial studies the effect of an ehealth coaching program (pack health) on patient reported outcomes of men with prostate cancer. an electronic health support program may affect prostate cancer patients' reported side effects and outcomes of care.

primary objectives: i. to model the trajectory of patient reported outcomes (pros), as measured by the national institutes of health (nih) patient reported outcomes measurement information system (promis) global health scale (version \[v\]1.2), among men newly diagnosed with prostate cancer who are engaged in either active surveillance or active treatment, while enrolled in an e-health coaching program. ia. to compare the trajectories of (pros) between men who are engaged in either active surveillance or active treatment, while enrolled in an e-health coaching program. secondary objectives: i. to evaluate the effect of digital health coaching program on: ia. physical and mental health of men newly diagnosed with prostate cancer as measured by the subscales of the promis global health scale (v 1.2). ib. the global health outcomes of men with prostate cancer who are in active treatment by active treatment type (i.e. surgery, radiation, chemotherapy, hormonal therapy, or a combination of these methodologies). ic. the symptom experience of men newly diagnosed with prostate cancer as measured by the md anderson symptom inventory (mdasi). id. the frequency of emergency room visits and hospital admissions for patients receiving treatment in the ambulatory setting. ii. to evaluate the relationship between financial toxicity, as measured by the consumer score for financial toxicity (cost), and quality of life, as measured by the expanded prostate cancer index composite for clinical practice (epic-cp). outline: patients are contacted once weekly by a health coach by text message, phone call, email, or a mobile application, for 3 months. the total time interacting with the health coach is about 3.5-4.5 hours across the study. patients also complete surveys over 30 minutes each time at baseline and every 30 days for 3 months.

Eligibility criteria:
inclusion criteria: * able to read, speak and consent in english * newly diagnosed (within 6 months of diagnosis) with prostate cancer * internet access via smart phone, tablet, a computer, or another device with the capacity to receive calls, texts, or e-mails, as well as the electronic study assessments exclusion criteria: * individuals who are terminally ill, defined as individuals identified by their physician as likely having 6 months or less to live, or those individuals transitioned to hospice care * individuals who have a prior diagnosis of prostate cancer * individuals for whom there is documentation of inability to provide consent in the medical record
iris followed by mfolfox6 or the reverse sequence in advanced colorectal cancer

Conditions: Metastatic Colorectal Cancer

Summary: this randomized phase iii study compares safety and efficacy of two sequence arms in advanced colorectal cancer: irinotecan and s-1 (iris) followed by oxaliplatin containing regimen (arm a), or l-leucovorin (l-lv), 5-fu and oxaliplatin (mfolfox6) followed by irinotecan containing regimen (arm b).

a multicenter randomized open-label controlled phase iii study is conducted in patients with inoperable advanced or metastatic colorectal cancer who receive no previous chemotherapy. usefulness of iris and mfolfox6 regimens as the 1st-line therapy for colorectal cancer is evaluated in pfs, mst, incidence and severity of adverse events

Eligibility criteria:
inclusion criteria: 1. histological diagnosis of colorectal cancer. 2） age: 18 - 75 years. 3） no prior chemotherapy 4） ecog performance status 0 to 2 5) a life expectancy of at least 3 months 6) adequate function of major organs (bone marrow, heart, lungs, liver etc.). wbc ≧3,500/mm3 and neutrophil ≧2,000/mm3. hb ≧10.0 g/dl. platelet count ≧100,000/mm3. ast and alt ≦2.5 times the upper limit of normal (excluding liver metastasis). t-bil ≦1.5 mg/dl. creatinine ≦1.5 mg/ dl. 7).patients must have the ability to understand and the willingness to sign a written informed contact document. exclusion criteria: 1. patients receiving blood transfusion, blood derivatives or granulocyte-colony stimulating factor within 7days prior to entering the study. 2. patients can not have oral intake 3. patients receiving flucytosine treatment 4. patients with severe pleural effusion or ascites. 5. patients who have brown brain metastasis 6. patients with diarrhea 4 or more times per day 7. patients with active gastrointestinal bleeding. 8. patients with intestinal obstruction 9. patients with active infection. 10. patients with serious pulmonary disease (such as interstitial pneumonia, pulmonary fibrosis, pulmonary emphysema) 11. patients with serious complications (such as intestinal paralysis, intestinal obstruction, interstitial pneumonia or pulmonary fibrosis, uncontrolled diabetes mellitus, heart failure, renal failure, or hepatic failure). 12. patients with significant cardiac disease. 13. patients with active multiple cancer. 14. patients with neuropathy ≥ grade 2 15. patients who are pregnant, are of childbearing potential, or breast-feeding. 16. patients with severe mental disorder. 17. patients with a history of serious allergic reaction. 18. judged to be ineligible for this protocol by the investigation. -

Keywords: irinotecan s-1 oxaliplatin l-leucovorin fluorouracil metastatic colorectal cancer phase iii
endovascular brachytherapy combined with stent placement and tace for hcc with main portal vein tumor thrombus

Conditions: Hepatocellular Carcinoma; Portal Vein Tumor Thrombus

Summary: it is a prospective and multi-center clinical research in china to compare the efficacy, safety and related impact factors between tace alone and endovascular brachytherapy combined with stent placement and tace for hcc with main portal vein tumor thrombus.

it is an open random prospective phase iii clinical trial conducted by principal investigator professor zhi-ping yan.investigators in twenty-seven hospitals in china participate in.patients with unresectable hcc with main portal vein tumor thrombus are enrolled. the investigators propose to recruitment 253 patients who are randomly assigned into the combined group (treated with endovascular brachytherapy combined with stent placement and tace) and the control group (treated with tace alone).there are 127 patients in combined group and 126 patients in control group. the criteria of inclusion and exclusion, and the methods of lab tests, imaging modality and treatment procedures are the same.

Eligibility criteria:
inclusion criteria: * (1) hepatocellular carcinoma(hcc) diagnosis confirmed by needle biopsy or by two coincidental imaging techniques associated with increased α-fetoprotein according to the american association for the study of liver diseases (aasld) guidelines; * (2) according to the barcelona clinic liver cancer staging classification, hcc was unsuitable for resection, liver transplantation or percutaneous radiofrequency ablation; * (3) tumor thrombus, a low-attenuation intraluminal filling defect extending from intrahepatic portal vein branches adjacent to primary tumor into main portal vein, was confirmed by contrast-enhanced abdominal computer tomography (ct) or magnetic resonance imaging (mri) * (4) at least the first-order branch of the intrahepatic portal vein was patent in one lobe; * (5) child-pugh classification grade a or b; * (6) eastern cooperative oncology group (ecog) performance status score of 2 or less; exclusion criteria: * (1) patients had a history of any therapy for hcc or portal vein tumor thrombus; * (2) advanced liver disease (bilirubin levels \>3 mg/dl, aspartate transaminase or alanine aminotransferase \>5 × upper limit of normal)； * (3) tumor invade the inferior vena cava, extrahepatic spread; * (4) any contraindication to an arterial procedure such as impaired clotting tests (platelet count below 50 × 109/l or prothrombin activity below 50 %); * (5) renal failure,cardiac ejection fraction (\<50 %) or end-stage disease; * (6) patients who were not capable of cooperation during the procedure.

Keywords: hepatocellular carcinoma main portal vein tumor thrombus endovascular brachytherapy stent chemoembolization
assessing parenteral antibiotics versus single-time intra-operative intra-dermal antibiotic administration for prevention of ssi

Conditions: Surgical Wound Infection; Surgical Site Infection

Summary: the purpose of the study is to study the incidence of surgical site infection when patients are given local versus parenteral antibiotics

patients undergoing above 18 years of age, giving consent and undergoing open or laparoscopic elective, cdc class i \& ii surgeries will be recruited. cases will be randomised into two cohorts viz: parenteral antibiotic (group a) vs single-time intra-operative intra-dermal antibiotic administration group (group b). in operation theatre, after induction of anaesthesia, group a will receive parenteral ceftriaxone (15-20mg/kg) whereas group b will receive single-time intra-operative intra-dermal ceftriaxone (15-20mg/kg diluted in 10 ml normal saline). post-operatively, incision site will be covered with occlusive dressing. first check-dressing will be done after 48 hours as per the existing institutional practices. after that surgical site will be inspected daily for wound infection. patients with healthy wound will be discharged at the discretion of the treating surgeon and will be asked to follow up in general surgery opd weekly for one month. cases who developed an ssi will have samples collected from the afflicted area for bacterial culture and antibiotic susceptibility testing. on development of ssi, the treating clinical team will commence antibiotic therapy as per their protocols.

Eligibility criteria:
inclusion criteria: * patients above the age of 18 years * patients undergoing open and laparoscopic elective, cdc class i \& ii surgeries exclusion criteria: * patients exhibiting hypersensitivity reaction to ceftriaxone * patients who are immunocompromised (retroviral disease and corticosteroid use) * patients not consenting to be a part of this study * pregnancy * febrile illness or leucocytosis at the time of surgery * planned for staged/multiple interventions during the hospital stay (endoscopies, image-guided biopsies etc) * patients with a possible septic focus distant from the surgical site such as diabetic foot ulcers.

Keywords: ceftriaxone surgical wound infection
study of an implantable functional neuromuscular stimulation system for patients with spinal cord injuries

Conditions: Spinal Cord Injury

Summary: objectives: i. establish the procedures for implementing and assessing the clinical utility of functional neuromuscular stimulation using an implanted eight-channel standing and transfer system in patients with incomplete tetraplegia or paraplegia. ii. develop and apply quantitative functional evaluations of system performance in these patients. iii. perform long term follow up and monitor system use outside of the laboratory.

protocol outline: patients undergo surgery in which electrodes are sutured into areas of the pelvis and legs. electrode leads are inserted into a receiver/stimulator implanted in a subcutaneous pocket in the abdomen. following implantation, patients undergo training in standing, transfers, and other advanced mobility skills using the functional neuromuscular stimulation system. restricted activity continues for 2 weeks after surgery, followed by 8 weeks of exercise. standing training then begins, and continues for up to 6 weeks. home-based training follows prior to discharge with the system for spontaneous use. patients are followed at 3, 6, and 12 months, then annually thereafter.

Eligibility criteria:
inclusion criteria: low cervical or thoracic spinal cord injuries (c6-t12) must be skeletally mature asia impairment scale a (complete motor and sensory deficits), b (sensory sparing), or c (motor and sensory sparing) intact lower motor neurons greater than 6 months since injury range of motion within normal limits no renal compromise no cardiac abnormalities no circulatory compromise no pulmonary compromise no acute or chronic psychological problems or chemical dependency no acute orthopedic complications (scoliosis, history of spontaneous fractures, dislocations, etc.) no acute medical complications (no skin breakdowns, uncontrolled seizures, immunological compromise, etc.) exclusion criteria: failure to meet inclusion criteria

Keywords: environmental/toxic disorders neurologic and psychiatric disorders rare disease spinal cord injury
supracondylar femur fracture after ddh

Conditions: DDH

Summary: incidence of ipsilateral supracondylar femoral fractures after cast removal for developmental dysplasia of the hip (ddh) surgery


Eligibility criteria:
inclusion criteria: * age 1-7 years old * primary ddh exclusion criteria: * • paralytic hip dx in cases of (cerebral palsy,meningomyelocele,neuropathy or myopathy) * recurrent cases of ddh * past history of ipsilateral distal femoral fractures

Keywords: ddh insufficiency fractures
effect of induction method in post operative agitation

Conditions: Emergence Agitation

Summary: to compare the effect of two different induction method; mask ventilation and intravenous cannulation on emergence agitation on pediatric adenotonsillectomy

many things cause emergence agitation after operations on pediatric population. this research aims determine which method, mask ventilation or intravenous cannulatin is more effective on emergence agitation

Eligibility criteria:
inclusion criteria: * pediatric adenotonsillectomy exclusion criteria: * patients with neurological, hepatic, renal disorders and using any drugs
evaluation of taihao breast ultrasound diagnosis software

Conditions: Breast Cancer; Breast Diseases

Summary: the br-uscad ds module is a computer-assisted detection and diagnosis software based on a deep learning algorithm. this retrospective, fully-crossed, multi-reader, multi-case (mrmc) study aims to compare the performances of readers without and with the aid of the breast ultrasound image reviewed with assistance of computer-assisted detection and diagnosis system (br-uscad ds) in interpreting breast ultrasound images of lesions.


Eligibility criteria:
inclusion criteria: * b-mode breast ultrasound image * female, age 21 or older * breast lesion images acquired before a biopsy or surgery - these images were retrospectively collected with histology report. * non-biopsied benign lesions with negative follow-up for a minimum of 24 months * at least two orthogonal views of a lesion exclusion criteria: * breast lesion images acquired after biopsy or surgery. * any breast surgeries or interventional procedures in the 12 months prior to ultrasound imaging * case demonstrating administrative or technical errors * multiple lesions in one 2-d ultrasound image * breast ultrasound images with doppler, elastography, or other overlays present * case with less than 2-year follow-up and without biopsy confirmation
effect of phacoemulsification on ocular blood flow in human

Conditions: Cataract; Hypertension; Diabetes

Summary: * to investigate ocular haemodynamics after phacoemulsification surgery * to evaluate the influence in people with different autoregulation of ocular blood flow


Eligibility criteria:
inclusion criteria: * age-related cataract * no complications during surgery exclusion criteria: * complications during surgery * have other complications

Keywords: blood flow
a dose escalation study of pf-06650808 in patients with advanced solid tumors

Conditions: Neoplasms; Breast Cancer

Summary: to assess the safety and tolerability at increasing dose levels of pf-06650808 in patients with advanced solid tumors in order to determine the maximum tolerated dose and select the recommended phase 2 dose.


Eligibility criteria:
inclusion criteria: * diagnosis of advanced/metastatic solid tumor that is resistant to standard therapy or for which no standard therapy is available * previously treated metastatic triple negative breast cancer that expresses notch3 with at least one measurable lesion * adequate bone marrow, renal and liver function exclusion criteria: * major surgery, radiation therapy or systemic anti-cancer therapy within 4 weeks of starting study treatment * patients with known symptomatic brain metastases requiring steroids * prior treatment with a compound of the same mechanism

Keywords: solid tumors triple negative breast cancer pf-06650808 phase 1