Kornimate/medical-research-clean huggingface dataset:
cognitive behavioral intervention for targeted therapy fatigue (cbt-ttf) intervention

Conditions: Chronic Myelogenous Leukemia

Summary: the purpose of this study is to evaluate cognitive behavioral intervention for targeted therapy fatigue (cbt-ttf) with fatigued chronic myelogenous leukemia (cml) patients on tyrosine kinase inhibitors (tkis) for feasibility, acceptability and potential efficacy relative to usual care only in a small-scale randomized controlled trial.


Eligibility criteria:
inclusion criteria: * able to speak/read english * diagnosed with chronic phase cml * not have been treated for other cancer (except non-melanoma skin cancer) in the past 5 years * be under the care of a moffitt cancer center (mcc) physician * be on a stable dose of the same oral tki for \>= 3 months * new onset or worsening of fatigue since starting tki * report moderate-severe fatigue in past week (fsi average rating \>= 4 of 0-10) * have no clinical history of disease (e.g., multiple sclerosis, fibromyalgia) that could account for their fatigue presentation exclusion criteria: * scheduled to discontinue their tki under medical supervision within the next 3 months

Keywords: cml chronic phase cml leukemia
an exploratory, observational, non-interventional, open label, remote pilot study to assess adherence in copd subjects

Conditions: Moderate Chronic Obstructive Pulmonary Disease; Severe Chronic Obstructive Pulmonary Disease

Summary: the purpose of this study is to monitor adherence to a clothing-attached breathing monitor, respiratory patterns, and activity levels in copd patients, and correlate those respiratory patterns and activity levels with patient-reported symptoms and events. to achieve this purpose, spire will collect data from a wearable monitor that participants attach to the participant's clothing, an associated smartphone application, and completion of weekly questions. the wearable monitor and the consumer smartphone application to be used are consumer products and currently available in the market. this study does not include clinical intervention and no doctors will be involved in this study. no clinical tests or office visits are included in this study. all data will be collected through an online survey tool and remotely through the wearable sensors.

this is an exploratory, observational, non interventional, single-arm, open label, remote pilot study involving up to 150 self-reported copd participants. eligible participants will wear the spire biophysiological health monitors for a period of 9 months while the participants report symptoms on a weekly basis via brief surveys. if and when participants incur a copd-related exacerbation which results in a medication change after hospitalization or contact with a healthcare provider, participants will report this on the weekly surveys. when this survey is read by a study nurse, the nurse will follow up with the participant by phone to conduct a post-exacerbation phone screening. this data would provide context to inform how to correlate the biosensor-sensed physiological parameters with the exacerbation self-reported data. all study participants will be remotely distributed throughout the united states.

Eligibility criteria:
inclusion criteria: * age ≥18 years old * self-reported diagnosis of moderate to severe copd * \>=1 self-reported copd-related hospitalization within the previous 12 months * currently using an iphone 6 or newer and willing to install the spire smartphone app * willing to wear health tags 80% of each 24 hour period and answer the email-based self-assessments weekly for the study duration * willing to provide consent to participate and abide by study protocol for study duration (9 months) * must be able to read and understand english * access to wi-fi at home and at work, for at least 20 hours per day (and smartphone connected to wi-fi throughout the study duration) exclusion criteria: * diagnosed with another medical condition that may confound the respiratory symptoms of copd (ex: cystic fibrosis, lung cancer, bronchiectasis, idiopathic pulmonary fibrosis, or chest wall deformities). * diagnosed with any neurodegenerative disorder (e,g, parkinson's, alzheimer's or epilepsy) * pregnant at the time of study or expecting to become pregnant throughout the course of the study.
intraoperative floppy iris syndrome

Conditions: Cataract; Floppy Iris Syndrome

Summary: an assessment of the surgical performance of discovisc compared to healon5 during cataract surgery with intraocular lens implantation where miotic/small pupils or intraoperative floppy iris syndrome exists.


Eligibility criteria:
inclusion criteria: * diagnosed with floppy iris syndrome * operable bilateral cataracts exclusion criteria: * intraocular pressure (iop) \> 21mmhg * ocular inflammatory disease * systemic or ocular diseases affecting endothelial cell count

Keywords: discovisc ophthalmic visco surgical device
duodenal exclusion for the treatment of type 2 diabetes

Conditions: Diabetes

Summary: the purpose of this study is to investigate the role of an experimental surgery that may offer better short and long-term control of t2dm in select patients who have not achieved adequate blood sugar control with regular means.


Eligibility criteria:
inclusion criteria: * age between 20 and 50 years old; * bmi between 27 and 34.9; * oral agents or insulin to control t2dm; * inadequate control of diabetes as defined as hba1c\>8.0% but \<10% * understanding of the mechanisms of action of the treatment exclusion criteria: * more than 5 years of t2dm diagnosis; * c-peptide \<1pg/ml (off insulin) * previous abdominal operations; * history of gastritis * history of gerd * history of peptic ulcer disease * inflammatory bowel disease * coagulopathy; * liver cirrhosis; * unable to comply with study requirements, follow-up schedule or give valid informed consent; * currently pregnant (pregnancy test required for confirmation for those of child bearing years) * patient is not available for programmed follow-up during the study period * patient is unwilling to forgo good samaritan blood donation during the study period
intravenous fentanyl or local anesthetic infiltration for pain reducing during spinal needle insertion

Conditions: Anesthesia; Spinal Puncture

Summary: background and objectives: spinal puncture is painful procedure which may cause patient refusal of spinal anesthesia in future surgery. it could be minimized with topical and infiltration local anesthetic or intravenous opioid application before procedure. objective was efficacy of intravenous fentanyl in alleviating pain during spinal needle insertion. methods: prospective, randomized study included 88 adults (33-55 ages, asa i/ii), scheduled for lower leg surgery. patients were divided in four equal study groups: spinal needle (quincke, 26g) with introducer (20g) was inserted alone, three minutes after local anesthetic infiltration (2 ml of 2% lidocaine, 25gx11/4" needle) or intravenous fentanyl application (0.001 mg kg-1) and without local anesthetic, fentanyl and introducer. pain was assessed immediately after procedure by vas score. map, hr and sao2 were recorded. sedation was assessed by ramsay score. statistical analysis was performed by spss 11.0.


Eligibility criteria:
inclusion criteria: * adults * asa i or ii status * scheduled for trauma or orthopedic surgeries of lower leg in spinal anesthesia exclusion criteria: * patients with scoliosis * degenerative spine deformity * a history of back surgery or back pain * pregnancy * perence of coagulopathy * systemic or local infection * allergy to amide-local anesthetics * neurologic damages and mental disability * more than one spinal puncture attempt * patient who was unable to estimate pain score * high ramsay sedation score

Keywords: anesthetic techniques regional, spinal pain lumbar puncture analgesia, local analgesia, intravenous
prevalence of nerd neck between different students at taibah university, saudi arabia

Conditions: CERVICAL

Summary: a convenient sample of 82 female students aged 18-24 years participated in analytic observational experiment cross section design. students were recruited into two groups, practical and non-practical. to answer the following 1. is there a difference in the prevalence of nerd neck between students of practical and non-practical studying groups at taibah university from the sitting position? 2. is there a difference in the prevalence of nerd neck between students of practical and non-practical studying groups at taibah university from the standing position?


Eligibility criteria:
inclusion criteria: * a convenient sample of 82 female students * the age was between 18-24 years * students were recruited from practical and non-practical faculties at taibah university. exclusion criteria: * we excluded any student with previous neck or back surgery or history of previous accident * also, any student with history of cervical column fracture injury, scoliosis, severe thoracic kyphosis, torticollis, persistent respiratory problems, rheumatic disease. * also we excluded any student with loss of standing balance and user of hearing aid
study to evaluate the safety and efficacy of vesatolimod in antiretroviral treated human immunodeficiency virus (hiv-1) infected controllers

Conditions: HIV-1 Infection

Summary: the primary objective of this study is to evaluate the safety and tolerability of a 10-dose regimen of vesatolimod in hiv-1 infected controllers on antiretroviral treatment (art) and during analytical treatment interruption (ati) following vesatolimod dosing.


Eligibility criteria:
key inclusion criteria: * plasma hiv-1 ribonucleic acid (rna) levels \< 50 copies/ml at screening * chronic hiv-1 infection (for ≥ 6 months) prior to art initiation * pre-art plasma hiv-1 rna set point between 50 and ≤ 5,000 copies/ml measured within two years prior to art initiation * on art for ≥ 6 consecutive months prior to screening * documented plasma hiv-1 rna \< 50 copies/ml for ≥ 6 months preceding the screening visit (or undetectable hiv-1 rna level according to the local assay being used if the limit of detection is ≥ 50 copies/ml). unconfirmed virologic elevations of ≥ 50 copies/ml (transient detectable viremia, or "blip") prior to screening are acceptable. * no documented history of resistance to any components of the current art regimen * availability of a fully active alternative art regimen, in the opinion of the investigator, in the event of discontinuation of the current art regimen with development of resistance. * hemoglobin ≥ 11.5 g/dl (males) or ≥ 11 g/dl (females) * white blood cells ≥ 2,500 cells/μl * platelets ≥ 125,000/ml * absolute neutrophil counts ≥ 1000 cells/μl * cluster of differentiation 4 (cd4)+ count ≥ 500 cells/μl * alanine aminotransferase (alt), aspartate aminotransferase (ast) or bilirubin ≤ 2 × upper limit of normal (uln) * estimated glomerular filtration rate ≥ 60 ml/min * no autoimmune disease requiring on-going immunosuppression * no evidence of current hepatitis b virus (hbv) infection * no evidence of current hepatitis c virus (hcv) infection (positive anti-hcv antibody and negative hcv polymerase chain reaction (pcr) results are acceptable) * no documented history of pre-art cd4 nadir \< 200 cells/μl (unknown pre-art cd4 nadir is acceptable) * no history of opportunistic illness indicative of stage 3 hiv * no acute febrile illness within 35 days prior to pre-baseline/ day -13 note: other protocol defined inclusion/exclusion criteria may apply.
hyperbaric oxygen for the treatment of a dry mouth which occurred after radiotherapy

Conditions: Radiation-induced Xerostomia

Summary: the purpose of this study is to determine whether hyperbaric oxygen is effective in the treatment of a dry mouth that occured after radiotherapy for head and neck tumours.


Eligibility criteria:
inclusion criteria: * complaints of xerostomia (visual analogue scale) * at least 6 months after radiotherapy of the head and neck region including all salivary glands with at least 50 gy * objective hyposalivation / xerostomia (at rest \< 0,25 ml saliva per minute, stimulated \< 0,1 ml saliva per minute) * patient must have given written informed consent exclusion criteria: * prior radiotherapy was an intensity modulated radiotherapy * prior hyperbaric oxygen therapy after radiotherapy * conditions which might be an additional risk for the treatment with hyperbaric oxygen such as spontaneous pneumothorax within the last two years, surgery of the eardrum or the middle ear, acute infection of the upper airways, not adequately treated epilepsy, concurrent radio- or chemotherapy, hereditary spherocytosis, psychosis, lung emphysema, asthma, severe copd, prior surgery of the thorax, pace maker * myocardial infarction within the last 6 months * drug therapy which might induce xerostomia * known intolerance or hypersensitivity to wrigley's freident® * pregnancy or breast-feeding women (for women aged less than 60 years a pregnancy test is mandatory) * women of childbearing potential with unclear contraception. the following contraceptive methods are recommended: combined oral contraceptives or progesterone-only pill, hormone-dispensing or copper intra-uterine system, hormone patches, long-acting injections, vaginal ring * treatment with other investigational drugs or participation in another clinical trial within 30 days prior to enrollment * refusal of cooperation or consent

Keywords: xerostomia hyperbaric oxygenation radiotherapy
feasibility of a multi component intervention in patients with severe dyspnea and obesity

Conditions: COPD; Emphysema; Lung Diseases

Summary: researchers are trying to test the effectiveness and feasibility of a multicomponent lifestyle intervention to support weight loss decreases dyspnea in obese people with chronic lung disease and clinically significant breathlessness.

patient will be randomized to a 12-week intervention that uses the weight watchers lifestyle program online, a garmin fitness tracker, blue tooth scale and receive health coaching vs a wait-list control group.

Eligibility criteria:
inclusion criteria * age ≥ 18 years. * bmi \>=35 * dyspnea mrc class ii or greater * diagnosis of lung disease * signed informed consent exclusion criteria * bmi \<35 * pregnancy * recent respiratory illness (within the last 6 weeks) * recent exacerbation of chronic lung disease (within the last 6 weeks) * already participating in a structured diet and/or exercise program * medical contraindication to weight loss (cancer) * medical contraindication to unsupervised exercise (unstable angina)
adjuvant adenoidectomy for the treatment of chronic ome in children

Conditions: Otitis Media With Effusion in Children

Summary: this study aims to verify the efficacy of adjuvant adenoidectomy for children with chronic ome who become candidates for tympanostomy tube placement, and explore potential factors associated with the efficacy of adjuvant adenoidectomy.

otitis media with effusion is a common condition in children, and tympanostomy tube placement is the first-line treatment for those who requires surgical interventions. adenoidectomy proves to be helpful to children over 4 years old, but the risks of adjuvant surgery is believed to somehow offset its benefits. this study is meant to verify if concurrent adenoidectomy provides extra benefits in resolving mee, reducing aom, and improving hearing and patients' quality of life to children who become candidates for tt.

Eligibility criteria:
inclusion criteria: * 1. children 4-12 years of age. * 2. diagnosed with chronic ome. diagnostic criteria: i. middle ear effusion detected by otoscopy; ii. type b or c tympanograms; iii. symptoms/signs of ome persisted for \>3 months; * 3. documented hearing loss ≥20db (average threshold of 500hz, 1000hz and 2khz in pure tone audiometry). * 4. adenoid hypertrophy (a/n ratio\> 0.5 in lateral radiography of the nasopharynx). * 5. informed consent given by the patients and their guardians. exclusion criteria: 1. cleft palate or other systemic disorders. 2. patients are diagnosed with other nose, sinuses or ear diseases that are eligible for surgical treatment. 3. patients are diagnosed with osahs, tonsil hypertrophy ≥ii° or scheduled for tonsillectomy. 4. history of tympanostomy tube placement. 5. infection of the upper respiratory tract or acute rhinosinusitis over the past 7 days. 6. sensorineural hearing loss. 7. other situations that the investigators find unsuitable for the trial.

Keywords: otitis media with effusion tympanostomy tube placement adjuvant adenoidectomy hearing outcome
duloxetine for the treatment of postpartum depression

Conditions: Postpartum Depression; Major Depressive Disorder

Summary: the purpose of this study is to assess whether the antidepressant, duloxetine, is equally effective as a treatment for subjects who have a postpartum onset depression compared to subjects who have an onset of major depressive disorder prior to delivery. the hypothesis is that duloxetine will be as effective in subjects with postpartum major depressive disorder as in subjects with a major depressive disorder.

study was terminated because of poor enrollment

Eligibility criteria:
inclusion criteria: * adult female subjects age 18 and above if onset of depression within 4 weeks of delivery,or onset of depression antenatally either during pregnancy or before pregnancy * must score greater than or equal to 12 on the edinburgh postnatal depression scale * speak english or spanish * have access to a telephone * provide written and verbal consent exclusion criteria: * have current or lifetime psychosis * an unstable medical condition * hypertension * narrow-angle glaucoma * liver disease * seizure disorders * bulimia * anorexia * mania * substance abuse disorders * have a known hypersensitivity to duloxetine or any of the active ingredients * are in need of inpatient hospital treatment with an excluded medication * adolescents under the age of 18 medication exclusion * other antidepressants * antipsychotic agents * quinolone antibiotics * type 1c antiarrhythmics * daily benzodiazepines * treatment with a monoamine oxidase inhibitor

Keywords: post partum depression
investigation of the effect of respiratory exercises on pain and functionality in individuals with rotator cuff syndrome

Conditions: Rotator Cuff Syndrome

Summary: as it causes pain and disability in individuals with rotator cuff lesions, which is one of the most common causes of shoulder pain, it affects performance in activities of daily living. shoulder pain significantly affects the quality of life of individuals. the aim of conventional treatment in rotator cuff injuries is to reduce the inflammation in the area and to enable the shoulder to perform its normal functions. conventional treatment is to restore muscle balance in the shoulder area. muscle balance is achieved by strengthening the teres minor, infraspinatus, and subscapularis, which are also the humeral head depressors, and by strengthening the serratus anterior, levator scapula. for strengthening, the shoulder must have a full range of motion. in our study, stretching exercises, cold pack, ultrasound, tens, wand, and codman exercises, which are classical physiotherapy methods, will be applied to all three groups. there are also studies in the literature investigating the effects of traditional physiotherapy methods on individuals with shoulder rotator cuff syndrome. the benefits of breathing exercises on pain, shoulder joint range of motion, and balance have all been researched in the literature. increased diaphragm activity also guarantees that posture and body positions are maintained healthily. diaphragm activity generally alters how an individual perceives pain. diaphragmatic breathing is a therapeutic approach for musculoskeletal disorders.

breathing techniques have been demonstrated to reduce shoulder pain and increase rom at the literature. however, no study has been found on the effectiveness of breathing exercises applied in addition to conventional physiotherapy in individuals with rotator cuff syndrome. based on all of this knowledge, it was designed for this study to examine the efficacy of breathing exercises used in combination with traditional physiotherapy in patients with rotator cuff syndrome.

Eligibility criteria:
inclusion criteria: 1. restricted shoulder joint range of motion 2. having rotator cuff syndrome 3. not having had any shoulder surgery 4. being between the ages of 18 - 65 exclusion criteria: 1. major trauma to the shoulder 2. anatomical deformities and skeletal system fractures 3. diagnosed orthopedic or rheumatological diseases 4. being included in a physiotherapy program in the last 6 months 5. having a cardiac pacemaker 6. presence of active infection 7. myocardial infarction in the last 6 months 8. participants who have any illness that prevents them from doing the exercises will be excluded from the study.

Keywords: respiratory exercises rotator cuff syndrome pain
catheterization laboratory study: acute responses in diastolic heart failure

Conditions: Heart Failure, Congestive

Summary: 1. research question: what is the response of the heart's pumping function to changes in heart chamber pressures? 2. experimental design: patients undergoing routine cardiac catheterization will be studied. a thermodilution pulmonary artery catheter will be inserted through a venous sheath and threaded into the pulmonary artery. after several minutes of quiet rest, baseline hemodynamics will be obtained, including a determination of cardiac output using thermodilution techniques and 30 seconds of pressure recordings from the left ventricle and proximal aorta. in addition, a brief echocardiogram will be performed, to determine ejection fraction and indices of diastolic filling. finally, arterial tonometry will be obtained in quick succession from the brachial, radial, femoral, and carotid arteries. following the collection of baseline data, a bolus and infusion of nesiritide will be started. after 10 minutes of nesiritide infusion, with the drug still infusing, a full set of invasive hemodynamics will again be obtained, as well as brief echocardiographic and arterial tonometry examinations.


Eligibility criteria:
inclusion criteria: * cardiac catheterization exclusion criteria: * unstable coronary syndrome, * critical coronary stenoses (\>90%), * severe peripheral vascular disease, * symptomatic hypotension at completion of routine diagnostic cath, * significant valvular disease, resting heart rate \>120 beats/min, * ejection fraction \<45%, * presence of contraindications to nesiritide administration, * any evidence of clinical instability.

Keywords: arterial stiffness echocardiography nesiritide high heart pressures cardiac catheterization
xebra study: an observational study of xeloda (capecitabine) in combination with docetaxel in first line in participants with her2-negative metastatic breast cancer

Conditions: Breast Cancer

Summary: this multicenter observational study will evaluate the efficacy and safety of xeloda (capecitabine) in combination with docetaxel in first-line therapy in participants with her2-negative metastatic breast cancer. participants will be followed for approximately 6 months of treatment.


Eligibility criteria:
inclusion criteria: * adult participants, \>/= 18 years of age * her2-negative metastatic breast cancer * participants initiated on first-line therapy with xeloda and docetaxel in accordance with the summary of product characteristics; participants who started treatment with xeloda and docetaxel no more than 3 months before enrollment in this study are also eligible exclusion criteria: * contraindications to xeloda treatment according to the summary of product characteristics