Kornimate/medical-research-clean huggingface dataset:
nissen sleeve by single port with magnetic assistance

Conditions: Bariatric Surgery Candidate; Obesity; GERD

Summary: new approach for nissen sleeve gastrectomy by single port using double magnetic system

a bariatric surgery is performed for weight loss and esophagogastric reflux, called nissen sleeve, in which a new approach is used which is the only port that helps to shorten the hospital stay because it decreases postoperative pain as well as increases the esthetic ad benefit. in addition, a system of magnets is used to assist in different steps of the surgery for the correct retraction of the tissues and to be able to suture or perform the correct dissection.

Eligibility criteria:
inclusion criteria: * any patient with controlled comorbidities suffering from obesity and gerd. exclusion criteria: * patients with pacemakers, psychiatric problems or uncontrolled metabolic diseases

Keywords: bariatric surgery magnetic assisted singe port nissen sleeve
effect of thiazolidinedione treatment vascular risk markers

Conditions: Diabetes Mellitus, Type 2; Vascular Diseases

Summary: the purpose of this study is to examine the effects of two diabetes medications, rosiglitazone and pioglitazone, on markers of vascular disease in subjects with type 2 diabetes.

diabetes is a common disease in the united states, affecting over 10 million americans. vascular disease, including heart attack and stroke, affects many diabetic patients and will cause the death of three-fourths of these patients. because the majority of diabetic patients will suffer complications or death from vascular disease, we will explore treatments that have the potential to reduce or prevent vascular disease in type 2 diabetes patients. our study will examine the effects of two diabetes medications, rosiglitazone (rosi) and pioglitazone (pio), on markers of vascular disease in 20 subjects with type 2 diabetes. it is thought that these two medications will reduce the risk of vascular disease by affecting the platelets and proteins that that regulate the processes involved in clot formation. one-half of the subjects enrolled in our study will take rosi and the other half will take pio. we will measure the clumping ability of these subjects' platelets before, during, and after three months of treatment with rosi or pio. we will measure the blood concentrations of several proteins (fibrinogen, pai-1, crp, adiponectin, and leptin) before and after treatment with the study drugs. these experiments will give us information about any beneficial effects of rosi and pio on the clot-forming ability in diabetes patients. we expect that treatment with rosi and pio will result in improvement of the disturbed clot-forming processes that predispose diabetic patients to vascular disease.

Eligibility criteria:
inclusion criteria: * men and women of all races * age 40-65 years * diagnosis of type 2 diabetes * hemoglobin a1c ≥ 7% * eligible whether or not currently taking antihyperglycemic medications exclusion criteria: * history of rosiglitazone or pioglitazone use in the previous 3 months * known diagnosis of peripheral vascular disease or cardiac failure * recent history (within past 6 months) of ischemic stroke, myocardial infarction, percutaneous coronary intervention, or coronary artery bypass surgery * active liver disease or elevated serum transaminases (alt \>2.5x upper limit of normal) * current therapy with oral anticoagulants (warfarin, heparin, low molecular weight heparin), clopidogrel, or immunosuppressive agents * pregnancy or breastfeeding * any other condition, in the opinion of the investigator, that renders the subject unable to complete the study, that interferes with optimal participation in the study, or that produces significant risk to the subject

Keywords: diabetes mellitus, type 2 vascular diseases thiazolidinediones platelet aggregation
the novel electrolyzed water spray treatment discomfort, redness and swelling of the skin surrounding the wound

Conditions: Skin Injury

Summary: the purpose of this study is to test whether the reduction of the sense of discomfort and redness and swelling of the skin surrounding the wound of patients by use of the novel electrolyzed water spray will relieve the inflammation of the skin.

in this study, water inculding tap water,pure water and salt water, and an apparatus for producing electrolyzed water (https://www.deposon.com.cn; https://www.deposon.com）were used to generate an electrolyzed water mist spray or spray. this instantly generated electrolyzed water mist spray or spray has oxidation-reduction potential (orp) ≥1200mv,and contains non-specific total oxidation capacity which equals to 0.28±0.10ppm,0.06±0.04ppm and 3.92±0.39ppm of desolved ozone. this instantly generated electrolyzed water mist spray or spray does not release detectable ≥0.1mg/m3 of gaseous ozone. this instantly generated electrolyzed water mist spray or spray has ph 8.4±0.4 and releases negative air ion.the apparatus for producing electrolyzed water has a positive electrode which is covered by a conductive diamond material (patent# cn215308550u). in this study, this novel electrolyzed water device and the water spray are used to treat wounds created by skin laser surgery.

Eligibility criteria:
inclusion criteria: * mild discomfort, redness and swelling of the skin surrounding the wound created by skin laser surgery * patient \> 18 years old. exclusion criteria: * severe discomfort, redness and swelling of the skin surrounding the wound created by skin laser surgery. * 80 years or older. * pregnant or breastfeeding women * systemically healthy individuals.

Keywords: electrolyzed water device hydroxyl radical tap water spray laser surgery wound discomfort of the skin redness of the skin
neuromuscular electrical stimulation in fibromyalgia

Conditions: Fibromyalgia

Summary: fibromyalgia syndrome (fms) is associated with chronic widespread pain and at least eleven positive tender points out of 18 according to the american college of rheumatology (acr) 1990 criteria. neuromuscular electrical stimulation (nmes) stimulates nerve fibers providing innervation in healthy muscle and muscle fibers in denervated muscle to produce contraction. all patients will be taught neck normal joint motion exercises, upper trapezius stretching exercise and posture exercises. patients included in the study will be randomly distributed equally between the two groups. in addition to the study group, nmes will be applied to the upper trapezius muscle for 30 minutes 5 days a week for 4 weeks. pain, disability and sleep quality of all patients will be evaluated.

fibromyalgia syndrome (fms) is associated with chronic widespread pain and at least eleven positive tender points out of 18 according to the 1990 criteria of the american college of rheumatology (acr) (1). pain and other symptoms associated with fibromyalgia interfere with daily functions, work and social activities, leading to a decrease in quality of life. neuromuscular electrical stimulation (nmes) stimulates nerve fibers that provide innervation in healthy muscle and muscle fibers in denervated muscle to produce contraction. studies on tens current in patients with fm have shown that pain decreases and functional status improves. however, although muscle weakness has been described in patients with fm, there are no studies on the effects of nmes application. all patients will be taught neck normal joint motion exercises, upper trapezius stretching exercise and posture exercises. patients included in the study will be randomly distributed equally between the two groups. in addition to the study group, nmes will be applied to the upper trapezius muscle for 30 minutes 5 days a week for 4 weeks. pain, disability and sleep quality of all patients will be evaluated.

Eligibility criteria:
inclusion criteria: * patients who were aged between 18-65 years, * patients who got diagnosed with fibromyalgia syndrome exclusion criteria: * patients who had regular exercise habits, malignancy, pregnancy, incorporation * patients who had changes of medical treatment in last 3 months * patients who had dysfunction that can prevent physical activity

Keywords: fibromyalgia neuromuscular electrical stimulation pain
impact of a computer-assisted sbirt program in an hiv care setting

Conditions: Substance Use

Summary: the goal of this research is to assess the impact of the "screening, brief intervention, and referral to treatment" (sbirt) intervention strategy for harmful substance use among hiv-positive people.

the specific aims of the study are: 1. to assess the feasibility of conducting sbirt using (1) a patient self-administered intervention embedded in a web-based personal health record (phr) compared to (2) a provider-administered sbirt intervention guided by the electronic medical record (emr) during clinic appointments. 2. to examine the acceptability of web-based phrs to conduct and communicate sbirt compared to emr-activated sbirt conducted by clinic staff, from the perspective of the patient and the provider. 3. to assess the impact of sbirt on risky drug and alcohol use in an hiv/aids population and subsequent effects on sexual risk behaviors and antiretroviral therapy (art) adherence.

Eligibility criteria:
inclusion criteria: * 18 years of age * confirmed prior hiv+ serostatus * ability to provide informed consent to be a participant over a 6 month period * english or spanish speaking exclusion criteria: inability to answer questions with interviewer assistance. not receiving primary care in clinic.

Keywords: hiv harmful substance use
water injection colonoscopy vs air insufflation colonoscopy in experienced endoscopists

Conditions: Colon Disease;; Rectal Disease;

Summary: water injection colonoscopy has been a generally accepted method in training the beginners of colonoscopy for its low pain and less cecal intubation time, the investigators would conduct this study to investigate advantages of this method for experienced endoscopists.

up to now, many studies has showed that compared with air insufflation colonoscopy, water-related colonoscopy could shorten the cecal intubation time and relieve the pain of the patients,especially for training the beginners，the effect was notable, but the present researches on water assisted technique has still been confined to following aspects:1.water infusing was based on air insufflation; predetermined amount of water was infused ,and water was infused while passing through certain segment of the bowel(such as the left half of colon) ; 2.when training the first-learners, certain dose of sedatives or analgesics was injected; 3.the patients recruited were less. colonoscopies in this study would be performed by experienced endoscopists of air insufflation colonoscopy, water would be injected completely instead of air insufflation while advancing the colonoscope, the amount of the water infused would not be predetermined but vary from individuals, and all the patients would be examined without any sedatives or analgesics.

Eligibility criteria:
inclusion criteria: * patients diagnostic colonoscopy; * subjets able to provide informed consent exclusion criteria: * prior partial or complete colectomy; * patients who decline to participate; * patients with poor bowel preparation; * contraindications of the colonoscopy
the relation between serum level of amioterminal propeptide of type i procollagen and diastolic dysfunction in hypertensive patients without diabetes mellitus

Conditions: Hypertension

Summary: in the present study, we assessed the relation between diastolic dysfunction and myocardial fibrosis in hypertensive patients without diabetes mellitus. a total of 20 medically treated ambulatory non-diabetic hypertensive patients with normal left ventricular (lv) systolic function were enrolled into this study. myocardial fibrosis was evaluated by serum concentrations of amino-terminal propeptides of type i and iii procollagen (pinp and piiinp). all patients underwent examinations of diastolic function by echocardiography and technetium-99m (99mtc) radionuclide ventriculography. there were 8 patients with pinp ≦53 μg/l (group 1) and 12 patients with pinp \>53 μg/l (group 2). patients in group 2 had significantly lower lv peak filling rate (pfr; 3.2 ± 0.3 vs. 2.5 ± 0.2 end-diastolic volume/s) and shorter time to pfr ( 257 ± 41 vs. 174 ± 22 ms). besides, the group 2 patients also had lower right ventricle pfr (1.9 ± 0.2 vs. 1.5 ± 0.1 end-diastolic volume/s) and shorter time to pfr ( 221 ± 29 vs. 154 ± 29 ms). echocardiographic parameters for lv diastolic dysfunction (e/a ratio of mitral flow, deceleration time of e flow, velocities of pulmonary venous flow \[retrograde a wave, systolic /diastolic velocity ratio\], isovolumetric relaxation time, tei index) were all comparable between two groups. in multiple regression analysis, lv time to peak filling rate was the only parameter that independently predicted serum pinp level (p\<0.05). in conclusion, elevated serum pinp level reflected lv diastolic dysfunction in hypertensive patients without diabetes.


Eligibility criteria:
inclusion criteria: * we enrolled 20 medically treated ambulatory, non-diabetic, hypertensive patients in this study. exclusion criteria: * patients with abnormal liver functions, leukocytosis, elevated serum levels of c-reactive protein, systolic dysfunction (lv ejection fraction \<50%) and lv hypertrophy due to etiologies other than hypertension were excluded from this study.
serum and peritoneal concentration in antibiotics during the surgical management of peritonitis

Conditions: Peritonitis; Critical Illness

Summary: spac is a pilote monocentric prospective study about peritonitis and antibiotics pharmacokinetic and pharmacodynamic. the investigators will included 50 patients during 2 years in the university hospital of nancy. the aim of this study is to determine if the beta-lactam dosages recommended by the guidelines for management of intra-abdominal infections (published by the société française d'anesthésie et de réanimation (sfar) in december 2015) permitted the achievement of adequatly serum and peritoneal concentrations in the medical and surgical management of peritonitis. the investigators will collected 3 pairs of serum and peritoneal fluid samples at 3 different times: peritoneal incision, arrival in icu and 24 hours after admission in icu in order to compare the concentrations and the minimal inhibitor concentration of bacteria. the hypothesis is that of a serum and peritoneal antibiotic under dosage.


Eligibility criteria:
inclusion criteria: * minimun age limits 18 years * all sex * patients with peritonitis (community or nosocomial) regardless of pathology involved * patients treated in the universty hospital of vandoeuvre les nancy (abdominal surgery unit and surgical intensive care unit jm picard) exclusion criteria: * beta lactam allergy * pregnancy * age less than 18 years * no respect of recommandations for antibiotics ( molecule and dosage) * person under legal protection

Keywords: therapeutic drug monitoring
photodynamic therapy with verteporfin for corneal neovascularization

Conditions: Corneal Neovascularization

Summary: purpose: to investigate the efficacy of photodynamic therapy with verteporfin for the treatment of patients with corneal neovascularization. design: prospective, non-comparative case series. participants: eighteen eyes of 18 patients with stable corneal neovascularization who were refractory to conventional treatment. methods: the patients were treated with photodynamic therapy with verteporfin (6 mg/m2). five patients were treated following penetrating keratoplasty, and 2 patients were treated before penetrating keratoplasty. best corrected visual acuity and anterior segment photography were performed before and after treatment. the length of cumulative blood vessels and area of corneal neovascularization were measured. main outcome measures: vascular occlusion, best corrected visual acuity, cumulative blood vessel length, and corneal neovascularization area.


Eligibility criteria:
inclusion criteria: * patients with clinically stable corneal neovascularization who were not improved after treatment with 1% prednisolone acetate eyedrops instilled 4 times a day for at least 1 month exclusion criteria: * individuals who had active keratitis with vessel proliferation, uncontrolled inflammation, active hepatitis or clinically significant liver disease, or porphyria or other porphyrin sensitivity
exergames on shoulder pain and motor function

Conditions: Shoulder Pain; Stroke

Summary: this study is to investigate the effects of exergame on shoulder pain and motor function of upper extremity in individuals with stroke.

background and purpose: stroke is a major cerebrovascular disorder causing various symptoms in the world. a substantial portion of those surviving from stroke typically experience neurological sequelae and stroke-related complications. post stroke shoulder pain is a sensory disturbance is one of a common complication in patients with chronic stroke and may adversely affect patients' quality of life. nowadays, exergame has been explored as an adjunct therapy for the management of pain for a number of conditions. this study is to investigate the effects of exergame on shoulder pain and motor function of upper extremity in individuals with stroke. method: this is a randomized controlled trail. sixty subjects with poststroke shoulder pain will be recruited and randomized into either the exergame (experimental) group or conventional (control) group. the intervention is one hour per day, four or five days per week for three weeks. the primary outcomes are visual analogue scale, and brief pain inventory - short form. the secondary outcomes are fugl-meyer assessment for upper limb extremity, wolf motor function test and shoulder pain and disability index.

Eligibility criteria:
inclusion criteria: 1. unilateral hemiplegia caused by stroke 2. modified ashworth scale ≤2。 3. mini-mental state examination ≥24。 4. age ≥20。 5. shoulder pain 。 exclusion criteria: 1. shoulder joint contructure 2. forzen shoulder 3. dizzness, lesion of auditory and vision.

Keywords: shoulder pain stroke motor function
exposure of salvaged blood to inflammation and oxidative stress: the effect of different anticoagulant regimes (hecics)

Conditions: Intra Operative Bleeding, Blood Salvage

Summary: the primary aim of this randomized controlled study is to determine whether the use anticoagulant citrate dextrose solution--formula a (acd-a) in cell salvage reduces inflammation and oxidative stress in cell saver blood compared to heparin. the secondary aim is to determine whether any differences in activation can be correlated to any differences in postoperative clinical outcome.

the first primary outcome of this study is the difference in concentration of pro- and anti-inflammatory markers and markers of oxidative stress in the cell-free fraction of the centrifugate of the unwashed autologous blood/anticoagulant mixture in the cell saver reservoir, after correction for cardiopulmonary bypass (cpb) time up to the start of the first washing cycle and contact time of the anticoagulant (either acd a or heparin) with the saved blood: * total antioxidant status (tas) * total thiols in proteins (ttp) * oxidized ldl (oxldl) * pro-inflammatory markers: interleukins (il), il-6, il-8, myeloperoxidase (mpo) * anti-inflammatory marker: il-10 the second primary outcome of this study is the difference in direct quality of the washed, salvaged red blood cells (rbc): * blood smear: evaluation by light microscopy * osmotic fragility * haemoglobin and hematocrit * free haemoglobin * free iron * lactate * ph confounding factors (cpb duration, contact time of anticoagulant with saved blood, time since first washing cycle in case of multiple washing cycles) will be controlled for. secondary outcome: the difference in concentration of the same pro/anti-inflammatory and oxidative stress markers in patient plasma preoperatively vs immediately before and after transfusion of cell saver blood (2 to 3 hours after transfusion and before extubation or transfusion of allogenous blood). * c-reactive protein (crp) * tas, ttp * oxldl * il-6, il-8, il-10 * mpo markers for hemolysis in patient plasma preoperatively vs immediately pre- and post-transfusion of the salvaged rbc (indirect quality of the washed salvaged rbc). * free hb * free iron, ferritin, transferrin * haptoglobin * hepcidin

Eligibility criteria:
inclusion criteria: elective cardiac revascularization surgery patients: subgroup analysis for * on pump coronary artery bypass grafting (cabg) * off pump cabg (opcabg) exclusion criteria: * urgent procedures * severe shock * active infection * inflammatory diseases * active neoplasia * immune suppressive drugs * active or recent renal replacement therapy (rrt) * anticoagulation or anti-aggregation therapy that hasn't been timely interrupted according to guidelines (12,13) * need for allogenous blood transfusion before completion of data collection * massive peroperative bleeding that cannot be safely managed while collecting study data
multi-modal exercise program in older aduls with knee osteoarthritis

Conditions: Osteo Arthritis Knee

Summary: aim: to evaluate the short-term effects of a multi-modal exercise program on physical performance variables in older adults with knee osteoarthritis.

* aim: to evaluate the short-term effects of 16 week multi-modal exercise program on physical performance variables in independent community-dwelling older adults with knee osteoarthritis. * design: randomized controlled trial. * setting: home-based intervention.

Eligibility criteria:
inclusion criteria: * age ≥ 60 years * knee pain * score in kellgren-lawrence scale ≥1 exclusion criteria: * unable to ambulate independently * mini-mental state examination score \< 24 * barthel index score \< 80 * unstable cardiovascular disease * neurological disorder that could compromise exercising * upper or lower-extremity fracture in the past year
screening for swallowing problems in patients following prolonged intubation: validation of the toronto bedside swallowing screening test (tor-bsst©)

Conditions: Dysphagia

Summary: despite medical advances, half of the patients admitted to hospital for recovery from acute illness, injury or surgery have swallowing difficulties and those requiring tubes for breathing support are at even greater risk. difficulties with swallowing decrease patients' quality of life, prolong their hospital stay, as well as lead to medical complications such as pneumonia, malnutrition and death. presently, there is no screening test for swallowing difficulties in patients who have required respiratory support. screening will allow for early detection of swallowing problems which is important to prevent serious complications, such as pneumonia. this research will determine the accuracy of a new screening test, the toronto bedside swallowing screening test (tor-bsst©) previously tested with stroke patients, to predict the presence of swallowing difficulties in patients who have required breathing support for longer than 48 hours. the investigators will enroll 100 patients from the intensive care medical surgical units at the university health network. the findings from this research will help identify those patients with swallowing problems earlier than it is currently possible. once identified, at risk patients will be referred to a speech language pathologist swallowing expert for more comprehensive testing; thereby, decreasing their risk of experiencing serious complications, such as pneumonia, secondary to swallowing problems.


Eligibility criteria:
inclusion criteria: * adults 18+ years * inpatient at university health network, in any of the medical-surgical intensive care units, regardless of disease type, comorbidities or previous medical history * received endotracheal intubation lasting 48 hours or longer exclusion criteria: * history of one or more of the following: neurological disorder, surgery to the head or neck, previous oropharyngeal dysphagia, tracheotomy in situ or dementia