Kornimate/medical-research-clean huggingface dataset:
radiological riskfactors for dislocation of hip hemiarthroplasty

Conditions: Dislocation; Femoral Neck Fracture

Summary: between january 1 2006 and december 31 2013, at our department 324 patients underwent hemiarthroplasty (ha) for displaced femoral-neck fracture with a bipolar prosthesis (variokopf, link®, germany) by the use of the posteriolateral approach. patients with pathological fractures and ha performed with direct lateral approach were excluded. a retrospective cohort study were conducted. patients with prosthetic dislocation formed one group and patients without dislocation formed the control group. as standard, post surgery radiographs (anteroposterior and lateral) were taken. after these were performed patient started weight bearing as soon as possible. clinical data regarding patient demographics, details of the surgical procedure and the medical comorbidities were collected by the use of patient and operative records. radiological analysis with position evaluation was performed using the post surgery radiographs by measuring wiberg angle, inequality of leg length and femoral offset of the prostheses and compared with non-operated hip joint using the post surgery x-ray images. our hypothesis were that patients with single- or recurrent dislocations had shortened postoperative leg length, decreased femoral offsed and a wiberg angle less than 25 degrees.


Eligibility criteria:
inclusion criteria: * femoral neck fracture * treated with hemiarthroplasty * through a posterolateral approach exclusion criteria: * direct lateral approach

Keywords: dislocation hemiarthroplasty femoral neck fracture femoral offset leg length difference wiberg angle
is there any differences in motor and cognitive development between preterm and early preterm infants?

Conditions: Premature Baby

Summary: infant born preterm have an increased risk of adverse long-term developmental outcomes.the risk associated with preterm birth increase as gestational age decreases, and vulnerability remains in extremely- very preterm (\ 32 weeks). there are many studies in the literature showed that the prevalence of developmental delay increases with premature birth. however, there is no study in the literature investigates long term follow up motor and cognitive development in subgroups of preterm infants . hence the aim of this study is to evaluate the differences in motor and cognitive development in moderate-late (\>32 weeks) and extremely-very preterm infants.

a convenience of infants with premature birth recruiting from gazi university, faculty of health science, department of physiotherapy and rehabilitation. babies divide into two groups according to the gestational ages. babies with gestational ages between 32-36 weeks and 6 days (including the given days) are categorized as moderate-late preterm, while those born before 32 weeks are grouped as extremely and very preterm. each group contains 20 babies. first, sociodemographic information and histories of babies are obtaining. ages and contact information of the parents are recording. prenatal and natal risk factors of the mothers are querying. gestational ages and height, weight, and head circumferences of babies at birth are recording. number of pregnancies, live births and abortions, type of delivery, multiple pregnancies for mothers as well as consanguinity between parents are asking.the alberta infant motor scale is using to evaluate spontaneous motor movements of the baby. it evaluates the baby at prone, supine, sitting, and standing positions. bayley scales of infant and toddler development scales screen for cognitive, language, and motor development in babies. all infants will be testing in 3-6-9-12-15-18-24 months of ages.

Eligibility criteria:
inclusion criteria: * adjusted age of 24 months or less, born with a gestational age of 36 weeks and 6 days or earlier, not having any systemic disease, and accepting to join the study exclusion criteria: * age greater than 24 months and born with a gestational age of 37 weeks or more * having major risk factor

Keywords: premature baby motor development cognitive development
pre- and postoperative use of zd1839 (iressa) in recurrent glioblastoma, including translational research

Conditions: Recurrent Glioblastoma

Summary: this study aims to determine effectiveness of gefitinib (iressa) in recurrent glioblastoma after standard treatment (surgery, radiationtherapy and at least a first line chemotherapy). gefitinib is a specific inhibitor of the epidermal growth factor receptor (egfr). egfr is elevated in more than 50% of malignant gliomas. at recurrence, secondary surgery and pre- and postoperative gefitinib is offered to patients in good performance status. clinical outcome of patients and correlation to translational research will be evaluated.

glioblastoma (gbm) patients who relapse and are in good performance status, without serious neurological deficits are offered secondary surgery and participation in the trial. eligible patients must have had standard treatment including primary surgery, radiation therapy and at least a first line chemotherapy. patients on cytochrome p450 isoenzyme cyp3a4-inducing antiepileptic drugs (eiae) are excluded due to ensuing interactions of these drugs with gefitinib metabolism, reducing systemic availability. after giving written informed consent, patients receive gefitinib 500 mg daily starting at least 5 days prior to re-operation, allowing a steady state condition.treatment continues until tumor progression or occurrence of intolerable side effects.the specimens collected at surgery will undergo translational research, aiming to correlate drug accumulation and molecular signatures of gbm samples with clinical outcome.

Eligibility criteria:
inclusion criteria: * recurrent glioblastoma * informed consent * reoperation planned * fresh frozen sample obtainable exclusion criteria: * enzyme inducing antiepileptic drugs * pregnancy or breast feeding

Keywords: recurrent glioblastoma, gefitinib
efficacy of rtms and vct on upper limb function in patients with stroke

Conditions: Cerebral Vascular Accident

Summary: stroke is the major cause of motor impairment and physical disabilities in the adult population. spasticity and loss of dexterity are the common problems in stroke. recently, current interventions, such as cycling training, virtual reality (vr) and repetitive transcranial magnetic stimulation (rtms), were used for the treatment of upper extremity (ue) dysfunction in patients with stroke. however, few studies investigated the effects of the combinations of different treatment strategies using by integrating brain imaging and motor control studies. this project proposes different novel treatment strategies in the treatment of ue dysfunction in patients with stroke: combined inhibitory/facilitatory rtms, vr-based cycling training (vct), and combined rtms and vct. we hypothesize that the treatment effect of the combined protocol (optimal rtms protocol and vct) is more effective than single treatment due to integration of central and peripheral effects. different treatment protocols will induce different changes in the brain reorganization and motor control, which further improve motor function, activity, participation, and health related quality of life (hrqol).

this study aims to 1. identify the immediate effects of different treatment protocols in for ue training in these patients through brain image, motor control and clinical measures; 2. to determine the maintaining therapeutic effects; 3. to elucidate the most optimal treatment protocols; 4. to determine the neuro-motor control mechanism underlying clinical improvement; 5. to determine the clinimetric properties of the brain imaging and motor control measure that are responsive and valid for detecting changes after treatment protocol intervention, and 6. to identify clinical predictors influencing the outcome for treatment protocols. the research will offer valuable motor control biomarkers for outcome prediction and targeting patients who benefit from new protocols. this project is significant for the translational and evidence-based medicine on stroke neurorehabilitation.

Eligibility criteria:
inclusion criteria: * first stroke * chronic stroke (onset \> 3 months) * unilateral cerebral lesion with hemiparesis or hemiplegia * age of 20-80 years * no epileptic spikes on the eeg exclusion criteria: * brain stem or cerebellum stroke * epilepsy * aneurysm * arteriovenous malformation * psychiatric disease * degenerative disease * severe cognitive and communicative impairment or aphasia * severe medical disease * active medical problems * metal implant in the body * pregnancy * poor cooperation with assessments

Keywords: repetitive transcranial magnetic stimulation stroke optimal treatment protocol vr-based cycling training (vct) randomized controlled trial motor control clinical predictors
surgical treatment in diabetic patients with grade 1 obesity

Conditions: Diabetes Mellitus; Obesity

Summary: surgical treatment in diabetic patients with grade 1 obesity

there will be a randomized clinical trial, non-blind, 1-arm treatment (duodenal ileal interposition with sleeve gastrectomy and selective intra-abdominal denervation for type 2 diabetes mellitus), including 40 research subjects with type 2 diabetes mellitus and obesity class i. in order to analise the effect on weight loss and glycemic control after 2 years of follow up

Eligibility criteria:
inclusion criteria: * documented diagnosis of type 2 diabetes mellitus * both sexes were treated with oral antidiabetic agents and / or insulin except the current treatment with glucagon-like peptide-1 (glp-1) receptor agonists or dipeptidyl peptidase 4 inhibitors * stable antidiabetic medication within the last 8 weeks prior to randomization (v2), if therapy includes insulin, the average daily dose should not have changed by more than 10% in the past 8 weeks * hba1c\> 8.0% * age\> 20 years and \<60 years * body mass index (bmi) of 30 35 kg / m² * agree to sign the consent form exclusion criteria: * type 1 diabetes mellitus (positive for anti-gad), or gad negative anti anti body with low β cell function (c-peptide after stimulation \<0.5 ng / ml) * current treatment with glp-1 receptor agonist and / or dipeptidyl peptidase 4 inhibitors * recent vascular event (myocardial infarction, coronary angioplasty or stroke in the past 6 months) * malignant neoplasm * portal hypertension * inability to cooperate with segment * low capacity of understanding surgery * unrealistic expectations of the outcome * cognitive impairment * current pregnancy * moderate or severe mood disorder; severe anxiety; eating disorders (based on diagnostic and statistical manual of mental disorders (dsm-v) criteria) * chemical dependency or alcoholism (based on dsm-v criteria).

Keywords: ileal interposition metabolic surgery diabetes intra abdominal selective denervation
physical activity in patients with gynecological surgery

Conditions: Women Who Underwent Midline Incision, Gynecological Surgery

Summary: examine whether the measurement and feedback of physical activity increase the physical activity in women who underwent midline incision, gynecological surgery


Eligibility criteria:
inclusion criteria: * midline incision, gynecological surgery exclusion criteria: * cannot ambulate * anticipated long term icu care * cannot wear accelerometer * anticipated discharge before postoperative day 5
investigating the relationship between temporal bone ct, bone density, and hearing loss in otosclerosis patients

Conditions: Otosclerosis of Middle Ear; Bone Density; Vitamin D Deficiency

Summary: the goal of this observational case-control study is to evaluate the relationship between temporal bone computed tomography (ct) findings, bone mineral density (bmd), and audiological parameters in adults diagnosed with otosclerosis. the main questions it aims to answer are: is there a correlation between temporal bone ct density values and the severity of hearing loss in otosclerosis? do bone mineral density and serum vitamin d levels differ between otosclerosis patients and individuals without otosclerosis? researchers will compare patients diagnosed with otosclerosis to a control group without otosclerosis to determine if ct-based density variations are associated with disease severity and systemic bone metabolism markers. participants who have already had a temporal bone ct scan as part of their routine clinical evaluation will undergo: bone mineral density (bmd) assessment via dual-energy x-ray absorptiometry (dexa) serum vitamin d level measurement audiological testing, including pure tone audiometry and speech discrimination tests this study aims to improve the diagnostic and prognostic understanding of otosclerosis by integrating imaging, metabolic, and audiological data.


Eligibility criteria:
inclusion criteria (otosclerosis group): * adults diagnosed with otosclerosis based on audiological and clinical assessment * patients with available high-resolution ct scans and audiological data * individuals who have undergone stapedectomy or stapedotomy surgery * availability of bone mineral density and serum vitamin d data inclusion criteria (control group): * patients without otosclerosis but with temporal ct imaging for other indications * no history of conductive or mixed hearing loss * availability of bmd and vitamin d data exclusion criteria: * history of primary metabolic bone diseases (osteoporosis, paget's disease) * use of medications affecting bone metabolism (bisphosphonates, corticosteroids) * history of chronic otitis media or prior ear surgeries * patients who received head and neck radiotherapy

Keywords: otosclerosis temporal bone ct bone mineral density (bmd) serum vitamin d audiology stapedectomy hounsfield units
the effect of remote postconditioning on graft function in patients undergoing living-related kidney transplantation

Conditions: Kidney Transplantation; Ischemic Reperfusion Injury; Remote Ischemic Postconditioning

Summary: the purpose of this study is to investigate whether upper limb ischemic postconditioning can improve renal function and decrease ischemic-reperfusion injury in patients undergoing living donor kidney transplantation.

ischemic reperfusion injury after kidney transplantation is a common clinical problem associated with a high morbidity and mortality. to reduce the adverse effect of ischemic reperfusion injury after organ transplantation, various strategies including ischemic preconditioning or postconditioning. remote ischemic postconditioning is one of such strategies where brief ischemic reperfusion injury of one organ protects other organs from sustained ischemic reperfusion injury. remote ischemic postconditioning of the limb with a tourniquet is a safe and convenient method of postconditioning organs against ischemic reperfusion injury. however, the efficacy of remote ischemic postconditioning in patients undergoing living donor kidney transplantation needs to be established. therefore, we investigate the efficacy of remote ischemic postconditioning of the upper limb with a tourniquet in recipients of kidney transplantation by measuring the markers of acute kidney injury.

Eligibility criteria:
inclusion criteria: * subjects undergoing elective living donor kidney transplantation * subjects older than 20 yrs who can give written informed consent exclusion criteria: * re-transplant recipients * those with peripheral vascular disease affecting the upper limbs free of arteriovenous fistula
ganyan-1 in dry eye

Conditions: Dry Eye; TCM

Summary: ganyan -1 for the patients with dry eye

objective: ganyan-1 for the patients with dry eye methods: the investigators enrolled 232 patients at beijing tongren hospital. patients completed questionnaires at baseline, week2, week4, week8, week12, and week16.

Eligibility criteria:
inclusion criteria: 1. age \>=18 and age \<=70, complaint of ded symptoms for 6 months or longer at screening. 3. ocular surface disease index (osdi) score of 25 or higher. 4. tear film breakup time (tfbut) of 5 seconds or less. 5. schirmer i test without anesthesia of 5 mm or more at 5 minutes. 6. cfs score of 4 or higher. exclusion criteria: 1. history systemic autoimmune diseases and ocular/periocular malignancy. 2. clinically relevant slitlamp findings or abnormal lid anatomy. 3. active ocular allergies and active infection. 4. pregnant or lactating women.

Keywords: dry eye tcm rct
characterization of bovine adrenal medulla as a new surrogate model of non-histaminergic itch

Conditions: Itch

Summary: with this experiment, the experimenter wish evaluate the role of trpa1 on non-histaminergic itch induced by bam8-22

with this experiment, the experimenter wish evaluate the role of trpa1 on non-histaminergic itch induced by bam8-22 2 (bovine adrenal medulla), which is found naturally in the human body and which has proved to evoke itch. to evaluate the role of trpa1 it will be used a trpa1 antagonist (a-967079)

Eligibility criteria:
inclusion criteria: * healthy men and women * 18-60 years * speak and understand english exclusion criteria: * pregnancy or lactation * drug addiction defined as any use of cannabis, opioids or other drugs * previous or current history of neurological, dermatological, immunological musculoskeletal, cardiac disorder or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.) * moles, wounds, scars or tattoos in the area to be treated or tested * lack of ability to cooperate • * current use of medications that may affect the trial such as antihistamines and pain killers. * skin diseases * consumption of alcohol or painkillers 24 hours before the study days and between these - acute or chronic pain • * participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)
prospective validation study of ai-based prediction algorithm for the prediction of paroxysmal atrial fibrillation

Conditions: Atrial Fibrillation Paroxysmal

Summary: the purpose of this study is to predict the occurrence of paroxysmal atrial fibrillation by finding high-risk group from normal sinus rhythm ecg through artificial intelligence-based prediction algorithm.

this study is a multi-center, prospective observational validation study. patients aged 18 or above who are hospitalized at our hospital or who visited the outpatient clinic with arrhythmia symptoms (such as palpitation) after the clinical research approval will be enrolled. the normal sinus rhythm electrocardiogram (ecg) at the time of participation in the study is recorded and put into the artificial intelligence prediction algorithm. the result of risk stratification is blinded and will not be informed to both the research director and subjects. after applying wearable devices to the subject, the ecg recorded for the first week is analyzed to confirm the occurrence of paroxysmal atrial fibrillation (the gold standard for diagnosis of atrial fibrillation). when the wearable devices are removed, the 12 lead electrocardiogram will be taken again, and if it shows normal sinus rhythm electrocardiogram, then it will be put into the artificial intelligence prediction algorithm to calculate the result as well.

Eligibility criteria:
inclusion criteria: * participants must be above 20 in age * participants are patients with symptom of arrhythmia who visited outpatient clinic or who have been hospitalized exclusion criteria: * excluding patients with cardiac implantable electronic device such as pacemakers, implantable defibrillators (icd), or cardiac resynchronization therapy (crt). * excluding pregnant women and lactating women.

Keywords: artificial intelligence electrocardiogram
heart rate variability change after liver transplantation

Conditions: Liver Transplantation

Summary: cirrhotic cardiomyopathy describes a hyperdynamic state with the presentation of high cardiac output and low systemic vascular resistance. and the latent heart failure becomes obvious under physiologic and pharmacologic stress. the goal of our study is to assess the effects of liver transplantation on the heart rate variability in patients with end stage liver disease.


Eligibility criteria:
inclusion criteria: * age:18-70y/o receiving liver transplantation exclusion criteria: * history of cardiovascular disease
pain treatment with combinations of nsaids

Conditions: Postoperative Pain, Acute

Summary: the search for new safe and effective methods of pain relief after surgery on large joints is still an urgent problem. the most optimal approach in the treatment of postoperative pain is the use of multimodal analgesia with a different mechanism of action that act on various mechanisms of pain and can include opioids, nonsteroidal anti-inflammatory drugs (nsaids), acetaminophen, anticonvulsants, nmda antagonists, alpha-2-agonists, and sodium and calcium channel blocking agents, as well as local anesthetics. nsaids are the most popular and safe means for pain relief. therefore, a lot of efforts are aimed at increasing the effectiveness of nsaids use. the aim of this study was to evaluate the effectiveness of simultaneously administering two or three nsaids, compared to using only one nsaid, for pain relief after surgery on large joints such as hip or knee arthroplasty.

this is 6 days, randomized, double blind, parallel group, single-center study in 105 subjects. the distribution into groups was carried out by sequentially alternating the set into 4 groups celecoxib 400 mg orally daily, aspirin 100 mg and ketorolac 90 mg orally daily, ketorolac 90 mg and celecoxib 400 mg orally daily; aspirin 200 mg, ketorolac 90 mg and celecoxib 400 mg orally daily.

Eligibility criteria:
inclusion criteria: * the patients with diagnosis of osteoarthritis of the knee or hip joint (m15.0, m16, m17) after primary knee or hip arthroplasty. * informed consent. exclusion criteria: * patients who cannot cooperate with the trial. * pregnant or breast feeding women, * оpioid addiction, * contraindication to nsaids (allergy to nsaid, history of ulcer and gastrointestinal bleeding, liver failure, renal failure (egrf \< 60 ml/kg/1,73m2) and chronic kidney disease 2-5, known thrombocytopenia (\<100 mia/l)

Keywords: postoperative pain non-steroidal anti-inflammatory drugs combination of nsaid aspirin ketorolac celecoxib