Kornimate/medical-research-clean huggingface dataset:
development of a predictive model of fetal ph at birth from novel variables derived from cardiotocographic tracing

Conditions: Pregnancies At Increased Risk of Preterm Birth

Summary: the goal of this observational study is to build a predictive model of fetal acidosis based on variables from the cardiotocographic tracing recorded during labor in participants undergoing spontaneous or induced delivery with single pregnancy.

cardiotocography is the current tool used to assess fetal well-being in labor and to identify cases of fetal distress early. we decided to conduct this study because the current interpretation of the cardiotocographic trace has limitations, related to the subjective interpretation of the trace. there are currently no predictive models that can reduce this margin of error. creating a predictive model of fetal acidosis, based on variables from the cardiotocographic tracing, could be useful in order to enable a better and more timely intervention. it can also be useful in reducing the rate of improper obstetric interventions. the recording of the cardiotocographic trace will take place throughout the duration of labor as per internal clinical management recommendations. once delivery has taken place (by cesarean section, obstetric suction or spontaneously), the data derived from the cardiotocographic tracing will be extracted using the sonicaid fetal care software from the cardiotocograph into a .csv file that will report for each second four measurements of heart rate and intensity of maternal contractions. the .csv file is converted to a .sav file and the new variables are generated, using a specially created spss script, in order to calculate the stability and variability of fetal heart rate. neonatal outcomes will be considered the dependent variable in this set of variables originated from the fetal heart rate patterns. the clinical variables that will be collected for the predictive model and/or for descriptive purposes are: * umbilical artery and vein ph * excess umbilical artery and vein bases * apgar score at birth * presence of dyed amniotic fluid * onset of active labor of delivery * onset of the expulsive period * fetal expulsion * cord rounds * mode of delivery * neonatal weight.

Eligibility criteria:
inclusion criteria: * maternal age between 18 and 45 years; * single pregnancy * participants undergoing continuous monitoring of labor labor * obtaining informed consent for study participation and processing of personal data exclusion criteria: * none

Keywords: fetal acidosis ph cardiotocography ctg
effects of sitting meditation and hatha yoga in adolescents

Conditions: Anxiety; Psychological Stress

Summary: the present study was a randomized controlled trial that explored the feasibility, acceptability, and effectiveness of short-term mindfulness training among adolescents. the primary purpose was to investigate the effectiveness of two main mindfulness-based stress reduction components-sitting meditation and hatha yoga-on working memory, stress, anxiety and mindfulness. the influence of daily home practice compliance on intervention outcomes was also examined.

the present study was a randomized controlled trial that explored the feasibility, acceptability, and effectiveness of short-term mindfulness training among adolescents. the primary purpose was to investigate the effectiveness of two main mindfulness-based stress reduction components-sitting meditation and hatha yoga-on working memory, stress, anxiety and mindfulness. the influence of daily home practice compliance on intervention outcomes was also examined. participants (n = 198 adolescents) were recruited from a large public middle school in southern california. participants were randomly assigned to sitting meditation, hatha yoga, or a waitlist control group. participants were asked to complete a computerized working memory task, and self-report measures of perceived stress, anxiety, and mindfulness at pre- and post-intervention/waitlist, as well as one-month follow-up. a series of mixed-design analyses of variance (anovas) were used to examine changes in working memory, stress, anxiety, and mindfulness between groups at pre- and post- intervention.

Eligibility criteria:
inclusion criteria: * students currently enrolled in school * between the ages of 12 - 17 years old * english speaking-to understand and complete the measures * able to attend the weekly hatha yoga or sitting meditation sessions * not reporting any injuries or health condition(s) that might limit their physical activity exclusion criteria: * hearing impairments, injuries, or physical disabilities that would hinder them from fully participating in intervention

Keywords: mindfulness adolescents working memory stress anxiety
multiple ascending dose study of spc4955 in healthy subjects

Conditions: Hypercholesterolemia

Summary: the purpose of this study is to study safety and tolerability of spc4955 in healthy subjects.


Eligibility criteria:
inclusion criteria: 1. healthy male or female subjects, age 18-65 years, inclusive. 2. bmi 18-33 kg/m2 3. screening hematology, clinical chemistries, coagulation and urinalysis consistent with overall good health and the following criteria are met: * ldl-c ≥3.24 mmol/l (≥125 mg/dl) * triglycerides (fasted) \<2.7mmol/l (\<239 mg/dl) * alt within normal limits exclusion criteria: 1. any uncontrolled or active major systemic disease including, but not limited to: cardiovascular, pulmonary, gastrointestinal, metabolic, urogenital, neurological, immunological, psychiatric, or neoplastic disorder with metastatic potential. 2. history or presence of malignancy within the past year. subjects who have been successfully treated (for 3 months or longer) with no recurrence of basal cell carcinoma of the skin or carcinoma in-situ of the cervix may be enrolled 3. active acute or chronic infection, including, but not limited to: upper airway infection, urinary tract infection, and skin infection 4. use of prescription medication within 14 days prior to the planned first drug administration and throughout the study. 5. use of non-prescription or over-the-counter medications is prohibited within 7 days prior to the planned first drug administration and throughout the study. this includes all vitamins, herbal supplements, or remedies. 6. positive results on the following screening laboratory tests: urine pregnancy test (women only), alcohol breath test, urine drugs of abuse, hepatitis b surface antigen, hepatitis c antibody, and human immunodeficiency virus (hiv) antibody.

Keywords: hypercholesterolemia ldl hdl apob hyperlipidemia lna-oligonucleotide
therapeutic exercise and education in neurophysiology of pain in the quality of life of women with endometriosis

Conditions: Endometriosis

Summary: the objective of this study will be to evaluate treatment using et exercise and pain education in women with endometriosis to achieve improvement in quality of life.

a study will be carried out whose objective is to improve the quality of life in women with endometriosis through a program of therapeutic exercise and education in the neurophysiology of pain. also as secondary variables will be observed: menstrual symptoms, sexual function, and abdominal wall thickness measured with ultrasound.

Eligibility criteria:
inclusion criteria: * women of reproductive age between 18 and 45 years. * women with a medical diagnosis of endometriosis. * women with visual analog scale (eva) between 4 and 10 (moderate-severe pain) during the last 3 months in the suprapubic area, abdomen or perineum both continuously and intermittently. exclusion criteria: * women who must have surgery during the study. * women who have undergone abdominal or pelvic surgery or who have given birth (vaginal or cesarean) in the last 6 months. * women who are pregnant or planning a pregnancy. * women with uncorrected pacemakers or coagulopathies, severe comorbid disorder, cancer (in the last 5 years or at present), severe mental disorders, or neuropathies affecting the nerves of the pelvis or lower extremities. * physiotherapy treatments or treatments related to pathology or study areas 15 days prior to the beginning of the study. * variations in medication in the 3 months prior to the start of the stud
genomics, single nucleotide polymorphisms (snps), and clinical neonatology

Conditions: Lung Disease; Brain Injury; Necrotizing Enterocolitis; Respiratory Failure

Summary: this research seeks to establish a neonatal dna tissue bank to find out if differences in small segments of dna predispose babies to chronic lung disease (cld), periventricular brain injury (pvi), necrotizing enterocolitis (nec), or hypoxic respiratory failure (hrf).

this genetic predisposition study does not involve investigational drugs, devices, or treatments. our broad goal is to identify genomic factors, which contribute to the development or exacerbation of common and critical illnesses that affect preterm and near-term infants. we seek to accomplish this goal in the following ways: * first: to test candidate gene dna variations and link already identified single nucleotide polymorphisms (snps) producing functional alterations to the risk of clinically important disorders. * second: to utilize a whole-genomic approach to identify snps not previously linked to the risk of development or progression of neonatal disorders.

Eligibility criteria:
inclusion criteria: * less than 34 weeks gestation and less than 1500 g at birth * greater than or equal to 36 weeks gestation and either with hypoxic respiratory failure or with mild respiratory distress never requiring assisted ventilation exclusion criteria: * life threatening anomalies of any organ system (e.g., cardiac, thoracic, lethal, or non-lethal chromosomal abnormalities)

Keywords: dna genomics snps neonatology chronic lung disease periventricular brain injury hypoxic respiratory failure
remote exercise testing in patients with pulmonary hypertension

Conditions: Pulmonary Hypertension

Summary: the investigators plan to investigate the feasibility and validity of tests of exercise capacity, when these are performed in hospital and at home, by patients who are diagnosed with pulmonary hypertension. patients with pulmonary hypertension develop high blood pressure within the lungs, leading to a limitation in the amount of exercise they are able to perform. at diagnosis and follow-up patients routinely perform short exercise tests which are performed under supervision in the clinic or hospital. the results from these are compared over time and are used to assess how stable patients are. currently, patients are required to travel to hospital to perform such a test and thus telephone or video appointments do not include this information. this study aims to investigate a range of exercise tests to assess whether they are valid in pulmonary hypertension (whether the results are comparable to the results from the current exercise test performed in hospital, the six-minute walk test) and whether it is feasible for patients to to perform these tests at home. the investigators aim to investigate four different home exercise tests, including a sit-to-stand test, a timed up and go test, a six-minute walk test and a step test. the investigators will ask patients to perform these tests in a hospital environment and at home on two occasions. the results of these will be compared to see how they change over time and will be compared to other results obtained during standard care. additionally, patients will be asked a questionnaire to assess their views on the four tests.


Eligibility criteria:
inclusion criteria: * aged 16-years-old and above * diagnosed with pulmonary hypertension from any ers/esc group * able to give informed consent exclusion criteria: * unable to provide consent * restricted so as unable to perform a standard 6mwt, either due to mobility or symptoms * patients feel they would be unable to perform any of the 4 study tests when at home * concerns about the patient's safety of performing home-based exercise tests (as decided by the consenting clinician and/or the patient)
bone healing in immediate dental implants

Conditions: Alveolar Bone Loss; Platelet Rich Plasma

Summary: to study the effect of platelet-rich plasma concentrate on marginal bone loss and bone mineral density in immediate implant placement through cbct.

12 subjects were equally categorized into two groups. group, i was the control group; whereas, the subjects in group ii received platelet rich plasma (prp) therapy. all subjects were given a standard treatment with single implant system. inserted implants were analyzed through cone beam computerized tomography (cbct). records were registered at the baseline, at 12th week before functional loading and 26th week after functional loading.

Eligibility criteria:
inclusion criteria: * patients maintaining good oral hygiene, having adequate bone quantity at the implant site, uneventful extraction exclusion criteria: * active infection around implant site, immunocompromised state, with current major systemic disease (uncontrolled diabetes, rheumatoid arthritis, etc.) or oral pathologies, history of bleeding disorders or on anticoagulant therapy, or patients on bisphosphonates were excluded from the study

Keywords: dental implant, cone beam computerized tomography (cbct).
ivf versus gonadotropin therapy in women with cc resistant pcos

Conditions: Infertility; Polycystic Ovarian Syndrome

Summary: the purpose of this study is to compare the efficacy of in vitro fertilization (ivf) versus gonadotropin therapy in infertile women having clomiphene citrate (cc) resistant polycystic ovarian syndrome (pcos).

women will be randomly divided into two groups; ivf group and gonadotropin group. women in the ivf group will undergo one full ivf cycle. women in the gonadotropin group will be subjected to ovarian stimulation for 6 months with the gonadotropin low-dose step-down protocol.

Eligibility criteria:
inclusion criteria: * infertile women with pcos as defined by the rotterdam criteria. * cc resistance (defined as failure of ovulation after receiving 150 mg/day of cc for 5 consecutive days per cycle, for at least 3 consecutive cycles). exclusion criteria: * age \ 35 years. * presence of any infertility factor other than anovulatory pcos. * previous history of ovarian surgery or surgical removal of one ovary. * previous exposure to cytotoxic drugs or pelvic irradiation. * oral hypoglycemic or hormonal therapy either currently or in the preceding 3 months. * metabolic or hormonal abnormalities.

Keywords: pcos clomiphene citrate resistant gonadotropin ivf
psychotherapy for bipolar ii depression, pilot study, phase ii

Conditions: Bipolar II Disorder

Summary: purpose of this study is to examine the effectiveness of an experimental psychotherapy (talk therapy) for the treatment of bipolar ii depression. the name of this psychotherapy is interpersonal and social rhythm therapy for bipolar ii depression (ipsrt-bpii). subjects will be randomly assigned to receive either ipsrt-bpii or the medication seroquel (quetiapine) to manage their symptoms of bipolar ii depression. subjects will receive the assigned therapy for up to 20 weeks.

the proposed pilot study is an experimental design intended to investigate the preliminary efficacy of interpersonal social rhythm therapy for bipolar ii depression (ipsrt-bpii). a total of 56 eligible subjects with a diagnosis of bipolar ii disorder will be randomly assigned to one of two treatment groups : seroquel (n=28) or ipsrt-bpii (n=28). following baseline assessment, all participants will undergo up to 20 weeks of their assigned treatment. patients assigned to ipsrt-bpii who fail to respond (at least 50% reduction in hrsd-25 scores and ymrs ≤ 10) by week 12 will have seroquel added to ipsrt-bpii. subjects who achieve remission (defined as 3 consecutive weeks where both hrsd-25 and ymrs scores average ≤ 7) and have participated in the trial for a minimum of 12 weeks will be moved into a continuation phase where they will receive maintenance treatment (bi-monthly therapy sessions and/or pharmacotherapy) until week 20. patients who do not achieve remission by week 20 will be discontinued from treatment and referred for follow-up care. all subjects (remitters and non-remitters) will be assessed at 20 weeks.

Eligibility criteria:
inclusion criteria: 1. meets dsm-iv criteria for bipolar disorder, type ii, currently depressed; 2. hrsd-25 ≥15 3. age 18-65 years; 4. able to give informed consent; 5. women of child bearing potential will be included if they agree to use adequate contraception for the duration of the study. exclusion criteria: 1. not competent to give informed consent in the opinion of the investigator (e.g., psychotic at time of evaluation); 2. unwilling or unable to comply with study requirements; 3. meets dsm-iv criteria for borderline personality disorder or antisocial personality disorder; 4. active substance abuse within the past 6 months(episodic abuse related to mood episodes will not exclude a subject); 5. currently a high suicide risk, as assessed by an active plan and intent to behave in a way that risks ending ones life; 6. non-english speaking; 7. significant, unstable, medical illness that might confound symptom scores or preclude treatment with pharmacotherapy 8. currently applying for disability because of psychiatric illness (we have found that these individuals have a vested interested in appearing to remain ill which potentially confounds outcome scores). 9. women who are pregnant, lactating or plan to become pregnant during their study participation.

Keywords: interpersonal therapy social rhythm therapy bipolar disorder depression seroquel
prevention of menstrual migraines: effects of estrogen add-back during the hfi in patients using continuous oral contraceptives.

Conditions: Menstrual Migraines; Menstrual Bleeding; Menstrual Spotting

Summary: this study will examine the combined effects of a continuous oral contraceptive (oc) regimen with supplemental estradiol therapy on headache severity and occurrence in subjects with documented menstrually associated migraines (mams). the subjects enrolling in the study will have cyclic menses either due to spontaneous ovulation or use of cyclic hormonal contraception (pill, patch, or ring). enrolled subjects will start a continuous oc regimen following two baseline menstrual cycles. if breakthrough bleeding/spotting (btb/bts) occurs, the subject will institute a 4-day hormone-free interval (hfi). in an attempt to prevent/lessen the severity of headache during the hfi, subjects will be randomized to oral estradiol or placebo during this period. if no btb/bts occurs after 80 days of continuous pills, the subject will institute a 4-day hfi during which they will be randomized into estradiol or placebo groups. the purpose of this research study is to examine the effects of continuous oral contraceptive pills and oral estradiol on headaches that occur around the time of your period. many woman take continuous oral contraceptive pills (oc) and when ocs are stopped they may get headaches. this study will examine if taking estradiol around the time of the period will affect the headache, and how it will be affected. this study is a prospective trial. a subject's participation will last approximately 32 weeks.


Eligibility criteria:
inclusion criteria: * women may be on birth control pill (oc), patch or vaginal ring taken in the traditional 21/7 or 24/4 manner, which means that every month they have a period. if they are taking it continuously (without a period), you must be willing to take your birth control 21/7 for 2 months. * if you are not on oc's, patch or vaginal ring you must have a period every 21-40 days. * you must not want to get pregnant for 12 months. * women who have headaches around the time of their period. exclusion criteria: * bmi \>38 * if you smoke and are age 35 years old or greater or if you are under 35 years old and smoke over 10 cigarettes a day. * if you have or had an aura with your headaches. (an aura is a temporary sensation, like bright lights that come before you experience the headache) * headaches are not occuring during the time of your period. * blood pressure \> 140/90 or you take more than a single antihypertensive medication (excluding diuretics) and are age 40 or greater. * contraindications to combination estrogen/progestin hormonal contraceptives. * desire to become pregnant in the next 12 months. * stroke * breast cancer * blood clots in your legs, lung or anywhere else in your body. * diabetes mellitus * heart attack * liver disease * systemic lupus erythematosus

Keywords: headaches migraines breakthrough bleeding breakthrough spotting menstrually associated migraines breakthrough bleeding or breakthrough spotting
nanodiamond modified gutta percha (ndgp) composite for non-surgical root canal therapy (rct) filler material

Conditions: Dental Pulp Diseases; Dental Pulp Necrosis; Nerve Root Pain Nec

Summary: non-surgical root canal therapy (rct) represents a standard of treatment that addresses infected pulp tissue in teeth and protects against future infection while preserving the tooth for the patient for mainly cosmetic purposes. rct is offered as the better cosmetic, cheaper, and less time intensive treatment option for a patient compared to those of dental implantation. dental implantation is the alternative to rct, and they are both originally offered at the time of the initial consultation. rct involves non-surgically removing dental pulp comprising blood vessels and nerve tissue, decontaminating residually infected tissue, and using a filler material to replace the non-surgically created space where the pulp was removed. currently, standard of care treatment for rct utilizes gutta-percha as the root canal filling material. our research group has previously demonstrated ndgp's improvement in tensile strength compared to those of gutta-percha. this research studies a new type of filler, gutta-percha modified by the addition of nanodiamond material (ndgp). this is an equivalence study of ndgp and standard gutta-percha administration.


Eligibility criteria:
inclusion criteria: * 18 years old or older when patient is referred to ucla endodontics department for root canal therapy * patient referral to ucla endodontics department for root canal therapy exclusion criteria: * preoperative periodontal disease * prior non-surgical and surgical endodontic treatment * currently taking medications used to treat osteoporosis or any form of iv biphosphonates * allergic to dental materials * dental phobia * md consult/medically compromised/prophylaxis needed * developmental/congenital disorders * craniofacial disorder/syndromic cases * low pain tolerance ascertained from past dental experience * current moderate to severe periodontitis * previous rct/initiated pulp therapy * previous apical surgery * previous surgical root canal procedure * with psychiatric and/or mental health history * poor oral hygiene * poor diet * illicit and/or recreational drug use * complicated dental history

Keywords: root canal therapy