Kornimate/medical-research-clean huggingface dataset:
weight change among users of three progestin-only methods of contraception over a 12-month time period

Conditions: Weight Change

Summary: the purpose of this study is to learn whether women who use progestin-only methods of birth control such as the contraceptive implant (implanon), the levonorgestral-releasing ius (mirena), or depot medroxyprogesterone acetate(dmpa) will experience weight change compared to women using the non-hormonal copper iuc (paragard). the investigators primary hypothesis is that users of dmpa will gain excess weight and increase their bmi above the copper-iuc users; secondarily, the investigators will compare users' data in the lng-iuc and eng implant groups to the copper-iuc group.


Eligibility criteria:
inclusion criteria: * patients enrolled in choice between the ages of 18 and 45 who consented to future studies * chose levonorgestrel-releasing iud, copper iud, the implant, or dmpa as their choice baseline method * has baseline height and weight data collected from the on-campus enrollment site * able to come back to the on-campus enrollment site for consent process and enrollment activities exclusion criteria: * recent history of dmpa use before starting their baseline choice method * used current method for less than 11 months or more than 12 months and three weeks

Keywords: weight change contraception birth control progestin progestin only weight gain depo depo provera dmpa iud iuc mirena paragard implanon implant
role of dietary habits in efficacy of bariatric surgery - study a

Conditions: Bariatric Surgery; Sleeve Gastrectomy; Obesity

Summary: the purpose of the study is to evaluate how dietary habits in the post-surgical year impact outcomes of bariatric surgery.

the obesity epidemic is a major public health concern with a significant economic burden in the usa. bariatric surgery is the most effective and durable weight loss treatment, with long-term cardiometabolic health benefits. among different types of bariatric procedures, sleeve gastrectomy (sg) has become the most commonly performed in usa. while sg is expected to result in a 50-60% excess weight loss, inter-individual differences in weight loss are large and approximately 25% of patients can be considered poor weight-loss responders who either do not lose a substantial amount of weight or regain the lost weight afterwards. the mechanisms underlying this clinical variation remain unknown and interventions to improve on these outcomes critically lacking. of interest, altered daily dietary habits are experienced by a substantial proportion of bariatric surgery candidates, raising the question whether such alterations may contribute to inter-individual differences in weight loss success. therefore, the purpose of this study is to evaluate how dietary habits in the post-surgical year impact outcomes of bariatric surgery.

Eligibility criteria:
inclusion criteria: * bariatric surgery (sleeve gastrectomy) patients exclusion criteria: * prior bariatric surgical procedures

Keywords: diet dietary habits weight changes
boston migraine and contraception study

Conditions: Headache

Summary: the objectives of this prospective, descriptive study are to: 1. generate estimates of the incidence, prevalence, persistence, clinical impact and attributable risk of migraine due to hormonal contraception (hc) use; and 2. identify predictive factors for clinically significant changes in headache attributable to hc use. the investigators hypothesize that: 1. most women with pre-existing migraine will have no significant change from baseline headache frequency or clinical impact attributable to hc at 3 months following initiation; a minority will report clinically significant worsening or improvement 2. the incidence of headache and migraine in hc users will not be significantly different from their incidence in nhc users 3. there will be identifiable risk factors for development or worsening of headache/migraine in the minority of hc users where that occurs.


Eligibility criteria:
inclusion criteria: * proficiency in english * medically eligible for her chosen form of contraception per standard pplm clinic protocol * (for study arm a) desire initiation of an estrogen/progesterone contraceptive method at time of clinic presentation and evaluation * (for study arm b) desire initiation of a progesterone only contraceptive method at time of clinic presentation and evaluation * (for control arm) initiating a non-hormonal contraceptive, or not initiating any contraceptive method * (for control arm) stated intention of not initiating any hormonal contraception over the 3 month study period * agreeing to study procedures exclusion criteria: * inability to speak and read english * (for control arm) use of hormonal contraceptive in the past 3 months * (for control arm) been pregnant in the past 3 months * states an intention to discontinue use of their newly initiated contraceptive (or lack of contraceptive) before the end of the 3 month study period * unwilling or unable to comply with study follow-up procedures * inability to give informed consent * previous participation in this study

Keywords: headache contraception
stoma related complications and quality of life assessments ethiopia and sweden

Conditions: Stoma Colostomy; Stoma Ileostomy

Summary: cross-sectional comparative study of general and stoma-specific quality of life in patients with stoma in addis abeba, ethiopia, and stockholm, sweden.

objective: to evaluate the quality of life for patients with ostomy in ethiopia and sweden using a general and a specific assessment tool. design: comparative descriptive cross-sectional study. setting: tikur anbessa specialized hospital (tash), addis abeba and south general hospital, stockholm. participants/exposure: patients with a permanent ostomy visiting the stoma center in addis abeba, patients waiting for ostomy reversal at tash, and patients visiting the stoma clinic at south general hospital. main outcomes and measure: quality of life and stoma specific quality of life: eq5d-5l and stoma qol.

Eligibility criteria:
inclusion criteria: * adult patients (≥ 18 years old) * having an ostomy for more than two months * willingness and ability to give informed consent exclusion criteria: * non-intestinal stoma
longitudinal cohort study - for the treatment of acute postoperative pain and postoperative delirium, postoperative cognitive dysfunctions, and chronic pain.

Conditions: Pain; Delirium; Postoperative Cognitive Dysfunction

Summary: adequate pain therapy is important aspect of perioperative care. sequelae of inadequate pain management are patient dissatisfaction, post-operative nausea and vomiting (ponv), inadequate nutrition, lack of mobilization, and an increased risk for the development of further complications, such as postoperative delirium (pod). the use of patient-controlled analgesia (pca) systems, which allow patients to self-administer analgesics, has improved pain management. conventional i.v. pca and the non-invasive administration of sufentanil sublingual tablets (zalviso®) are available. the aim of this investigation is to study patient controlled analgesia systems and to examine the incidence of pod, pocd and postoperative pain.

there are strong evidence-based recommendations for an appropriate assessment and treatment of postoperative pain. due to the complex and subjective nature of pain, an adequate pain therapy is an extremely challenging task, and the under- or overdosing of analgesics are common. an inadequate pain therapy leads to patient dissatisfaction, post-operative nausea and vomiting (ponv), inadequate nutrition, lack of mobilization, and an increased risk for the development of further complications, such as postoperative delirium (pod). other long-term consequences of an insufficient postoperative analgesia include the chronification of pain and post-traumatic stress disorder (ptsd). conversely, excessive opioid therapy may be associated with increased risk of pod. subsequently, patients with pod have an increased risk for the consecutive development of postoperative cognitive dysfunction (pocd). the latter is marked by a progressive and permanent loss of cognitive abilities, which can ultimately lead to dementia. the use of patient-controlled analgesia (pca) systems, which allow patients to self-administer analgesics, has been an improvement in the prevention of under- and overdosage of analgesics. currently, there are two systems available: conventional i.v. pca with patients being dependent on an i.v. line and a pca-pump and a patient-controlled, non-invasive administration of sufentanil sublingual tablets (zalviso®). the aim of this investigation is to study patient controlled analgesia systems and to examine the incidence of pod, pocd and postoperative pain.

Eligibility criteria:
inclusion criteria: * patients undergoing elective surgery with planned use of a patient-controlled analgesia system for postoperative pain therapy exclusion criteria: * children (\<18 years of age), * pregnancy and lactation * emergency surgery * accommodation in an institution due to an official or judicial order * participation in other clinical studies 30 days before study inclusion and during the study period * refusal of the patient * chronic opioid therapy \> 3 months before surgery with an oral morphine sulfate equivalent \>20mg/day * lacking willingness to save and hand out pseudonymized data within the study
clinical and genetic characteristics of coronary artery disease in chinese young adults

Conditions: Coronary Artery Disease; Percutaneous Coronary Intervention

Summary: the aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (cad) in chinese young adults. investigators will compare coronary angiogram results to genetic findings within young cad patients.

during last 10 years, the rise in coronary artery disease (cad) prevalence in chinese young adults is observed and percutaneous coronary intervention (pci) is generally considered to be low operative risk in these young patients. genome-wide association studies have identified a considerable number of common genetic variants related to cad. however, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with cad is not clear. the aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of cad in chinese young adult. investigators will compare the angiogram results to genetic findings first in patients with different stages of cad. then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups. the results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.

Eligibility criteria:
inclusion criteria: 1. premature cad, includes patients who aged ≥ 18 and ≤ 45 years , and with at least one main coronary artery stenosis ≥ 50% confirmed by coronary angiography, involving left main coronary artery, left anterior descending branch, left circumflex branch or right coronary artery, and manifested as occult cad, stable cad, unstable angina pectoris, non-st segment elevated myocardial infarction and st segment elevated myocardial infarction; 2. mature cad, refers to patients who aged ≥ 65 years and meat the same cad diagnostic criteria as above; 3. age matched individuals who had coronary arteries without obvious stenosis. exclusion criteria: 1. severely sick with limited life-expectancy \< 1 year; 2. patients with malignancies; 3. pregnant or planning for pregnancy.

Keywords: young patient genetic characteristics
healthy volunteer undergoing painful stimuli with and without hypnosis and virtual reality

Conditions: Digital Sedation

Summary: the main purposes of this study are as follows: compare the effect of painful stimuli with and without hypnosis and virtual reality (hvr) on healthy volunteers. * use of sensors and captors to monitor physiological and neurophysiological changes by painful stimulus * monitor level of pain and anxiety with and without hvr * monitor level of unpleasantness of the pain with and without hvr * monitor level of anxiety, absorption, dissociation, satisfaction and comfort with and without hvr

the control of pain and anxiety in a hospital environment is usually managed by pharmacological means that involve a series of risks and side effects. for many years, non-drug solutions have been of interest to the public and the care staff. the benefits of hypnosis and of virtual reality are highlighted in many studies and today allow a different approach to medicine. it is important to invest in tools that are less expensive and also effective for the well-being of the patient and the care staff. the use of a blended solution using both clinical hypnosis and virtual reality has been only scarcely documented.

Eligibility criteria:
inclusion criteria: - 18 years old to 70 years of age exclusion criteria: * deaf subject * blind * non-proficiency in french (research language) * psychiatric disorder * patient under 18 years old * phobia of deep water * head or face wounds * claustrophobia * neurological disease * allergy to cutaneous electrodes * chronic pain and/or chronic analgesics consumption * medication affecting the autonomic nervous system * dizziness

Keywords: virtual reality , hypnosis, pain, anxiety, anesthesia
choroidal thickness in beta-thalassemia patients

Conditions: Beta-Thalassemia

Summary: the purpose of this study is to examine choroidal thickness in beta-thalassemia patients and compare it to the one of healthy controls. an equal number of transfusion dependent beta-thalassemic patients and age and sex matched healthy volunteers will undergo spectral-domain optical coherence tomography utilizing the enhanced depth imaging application to visualize and measure the choroid.

beta thalassemia is an inherited hemoglobinopathy, associated with defective production of beta-chain globin resulting in problematic hba production. it is classified according to the severity as minor, intermedia and major. patients suffering from beta-thalassemia intermedia and beta-thalassemia major require regular blood transfusions. transfusion related hemosiderosis in these patients necessitates the use of chelating agents to prevent iron overload in vital organs such as the liver and heart. a number of ocular abnormalities can present in beta-thalassemia patients. those are categorized as pseudoxanthoma elasticum (pxe)-like changes that include angioid streaks, peau d'orange like fundus and optic nerve head drusen and non-pxe-like changes such as increased venous tortuosity. furthermore, it is well established that prolonged treatment with some of the chelating agents such as deferoxamine are associated with ocular toxicity, namely nyctalopia, colour perception anomalies, visual field disturbances, cataract formation, optic neuropathy and pigmentary retinopathy. the pathophysiology of those ocular manifestations has not been fully clarified. the role of the choroid has not been determined since this particular tissue was previously unaccessible to imaging. enhanced depth imaging optical coherence tomography is able to image the choroid providing reasonable clarity compared to spectral domain optical coherence tomography. the aim of this study is to evaluate possible alterations of choroidal thickness in beta thalassemia as compared to healthy controls.

Eligibility criteria:
inclusion criteria: * beta thalassemia patients undergoing blood transfusions exclusion criteria: * history of glaucoma, keratoconus, retinal disease, ocular trauma, ocular surgery, uveitis, amblyopia, strabismus, ocular vascular abnormalities * spherical refractive error greater than 4 diopters or cylindrical refractive error greater than 2 diopters * history of other systemic disease such as uncontrolled hypertension, diabetes mellitus, or connective tissue disease.

Keywords: beta-thalassemia choroidal thickness enhanced depth imaging optical coherence tomography
cell mediated immunity for secondary prophylaxis in cmv sot patients

Conditions: Cytomegalovirus Viraemia

Summary: this study will evaluate whether a test for cytomegalovirus (cmv) specific cell-mediated immunity can be used to determine whether patients who complete a course of therapy for cmv viremia need secondary antiviral prophylaxis. subjects that have negative cmv cmi will receive antiviral prophylaxis for 2 months and those with positive cmv cmi will have their prophylaxis stopped.

cytomegalovirus (cmv) is the most important infection in transplant patients and it is a common cause of illness in patients who have undergone a transplant. serious infections due to cmv can affect many parts of the body including the lungs, the gut, and the liver; when cmv infection becomes serious enough to cause symptoms, it is called cmv disease. some patients require treatment while others will clear the virus on their own. quantiferon-cmv (qft-cmv) is a blood test that measures cmv-specific cell-mediated immunity. this test was able to predict that patients with low cell-mediated immunity are at greater risk for developing cmv disease. in this study, qft-cmv will be used to make a decision regarding cmv treatment. the qft-cmv test will be performed at the first detection of cmv, at end of antiviral therapy and one month post-therapy. the end-of-therapy results will be available to clinicians and study investigators within one week of collection. based on the result, a decision will be made to continue with prolonged antiviral therapy. patients that show weak cell-mediated immunity against cmv will be given secondary antiviral prophylaxis, while patients with good cell-mediated immunity will have their therapy stopped. patients will continue to be monitored three months after the last qft-cmv test for recurrent cmv viremia. this study will also attempt to evaluate the predictive value of the quantiferon-monitor (qft-monitor) assay. qft-monitor is a recently developed non-pathogen specific immune assay: it is based on immune activation of both innate and adaptive immunity. the investigators hypothesize that stimulation of both the innate and adaptive immunity may predict global immune function and also be predictive of cmv reactivation. the investigators plan to perform the qft-monitor assay in parallel to the qft-cmv test to determine the test characteristics and cut-off values in predicting global immune function. this test will be collected and tested in batches. therefore, the results will not influence clinical decisions.

Eligibility criteria:
inclusion criteria: * adult solid organ transplant (sot) recipient on at least one immunosuppressive medication * starting therapy for new onset asymptomatic cmv viremia or starting therapy for new onset cmv disease * cmv viral load ≥ 1000 iu/ml exclusion criteria: * known ganciclovir-resistant cmv * known intolerance to valganciclovir or ganciclovir * unable to comply with protocol

Keywords: quantiferon-cmv quantiferon-monitor solid organ transplants cmv disease
stellate ganglion block for preserving arteriovenous fistula in hemodialysis patients undergoing major lower limb orthopedic surgery

Conditions: Stellate Ganglion Block; Arteriovenous Fistula; Hemodialysis; Major Lower Limb Orthopedic Surgery

Summary: the aim of this study is to evaluate the role of stellate ganglion blockade (sgb) for preserving arteriovenous fistula in hemodialysis patients undergoing major lower limb orthopedic surgery.

the best way for dialysis in chronic renal failure (crf) patients with consideration of feasibility, rate of infection, and patency is hemodialysis by using native access by using arteriovenous fistula (avf). altered calcium and phosphor metabolism in crf patients would also increase vascular reactivity. stellate ganglion blockade (sgb) has been used for several years for both diagnosis and treatment of circulatory problems in upper extremity. recently preemptive sgb has been used in prevention of radial artery spasm in coronary artery patients. sgb increases blood flow and decrease vascular resistance in the arm. sgb prevents or ameliorates the reactivity of the muscular layer of the ra in response to both surgical manipulation during harvesting the artery and to the potent vasoconstrictor mediators released during surgery

Eligibility criteria:
inclusion criteria: * age 21 to 75 years. * both sexes. * american society of anesthesiologists (asa) physical status iii. * chronic renal failure (crf) patients. * undergoing major lower limb orthopedic surgery. exclusion criteria: * psychiatric disorders. * history of substance abuse. * ipsilateral brachial and radial artery stenosis. * allergy to local anesthetics. * cardiovascular and respiratory disorders. * coagulopathy. * use of vasoactive medications. * obesity (body mass index \>30 kg/m2). * smoking.
comparison of remimazolam and propofol in endoscopic examinations and treatments

Conditions: Postoperative Complications; Respiratory Depression; Postoperative Nausea; Vomiting; Constipation

Summary: this study aims to evaluate the efficacy and safety of remimazolam, either used alone or in combination with propofol, for moderate sedation anesthesia during endoscopic therapies or examinations. additionally, it seeks to explore whether their combination can further enhance the quality of patient anesthesia and recovery outcomes.

objective this study aims to evaluate the efficacy and safety of remimazolam, either used alone or in combination with propofol, for moderate sedation anesthesia during endoscopic therapies or examinations. additionally, it seeks to explore whether their combination can further enhance the quality of patient anesthesia and recovery outcomes. methods the investigators will conduct a prospective, randomized, single-center study. eligible patients will be randomly allocated into three groups: the first group receiving propofol alone for moderate sedation anesthesia (control group), the second group receiving remimazolam alone for anesthesia, and the third group receiving a combination of propofol and remimazolam for anesthesia. the investigators will record anesthesia depth (dsa values of bis), heart rate, blood pressure, oxygen saturation, and other indicators during the procedure, as well as postoperative recovery time, time to consciousness recovery, oxygen desaturation, instances of inadequate anesthesia depth, intraoperative patient movement or recall, surgeon satisfaction, patient satisfaction, readmission rate within 14 days, complications, and length of hospital stay.

Eligibility criteria:
inclusion criteria: * subjects are between 20-80 years old. * anesthesiologists rated asa as between i and iii. * patients undergoing upper gastrointestinal endoscopic examination or therapy. exclusion criteria: * allergy to propofol, remimazolam, or opioid medications. * emergency surgery. * pregnancy. * history of malignant hyperthermia. * impaired liver or kidney function. * airway difficulties due to pharyngeal tumors. * refusal to participate.

Keywords: endoscope respiratory depression remimazolam、 sedation byfavo