Kornimate/medical-research-clean huggingface dataset:
cerebrovascular response to acute exercise

Conditions: Healthy; Physical Activity

Summary: cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. this study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities. the research aims are: 1. to determine if a single bout of aerobic exercise acutely enhances cerebrovascular function 2. to determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults. 3. to determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.

Eligibility criteria:
inclusion criteria: * between 20-40 years old * bmi \< 30 kg/m2 * recreationally active * experience running on a treadmill exclusion criteria: * current smoker * history or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes * taking blood pressure medication * history of depression or other mood related disorders * part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Keywords: exercise treadmill vascular function intensity
simplified insulin regimen for the elderly

Conditions: Type 2 Diabetes Mellitus

Summary: basal-bolus insulin therapy, which includes one injection of long acting insulin and three injections of short acting insulin is the most commonly used insulin treatment. however, many older patients find the basal-bolus insulin regimen hard to manage because it involves 4 injections and 4 blood glucose tests each day. it is possible that a simplified treatment that involves one injection of long acting insulin daily and two blood glucose tests daily might be equally effective. this simplified regimen, if effective, would be easier to use and might result in less errors. therefore, the investigators want to conduct this study to compare using a single daily injection of basal insulin with the usual basal-bolus insulin regimen in elderly patients (age \>65 years) with type 2 diabetes.


Eligibility criteria:
inclusion criteria: -age \>65 years exclusion criteria: * unable to provide informed consent * enrollment in another research study * history of hypoglycemia unawareness * pregnant women * prisoners

Keywords: diabetes elderly insulin treatment quality of life
rectal balloon training in female urinary incontinence

Conditions: Urinary Incontinence

Summary: urinary incontinence (ui) is a common and worldwide problem.although pelvic floor muscle training(pfmt) is the standard recommendation for conservative treatment but some patients had difficulty doing pfmt. they could not locate the pelvic floor muscles, and so could not perform the pfmt properly or increase intensity of the exercise. the authors hypothesized that rectal balloon training(rbt) may improve patients' pelvic floor recognition as well as it is another option of progressive strengthening of pelvic floor muscle. this study's aim is to combine rbt with pfmt using the water-filled balloons of foley catheters

this study's aim is to combine rbt with pfmt using the water-filled balloons of foley catheters. the catheter would be inserted into the rectum and used as a tool to help the patient recognize the pelvic floor muscles. the advantages of foley catheters are that they are cheap, safe for contacting the mucosa, easy for self-insertion, and can be reused. furthermore, we can increase the load of exercise by increasing the amount of water pushing into the balloon, and can use that as a tool for progressive resistive exercise.

Eligibility criteria:
inclusion criteria: * female * age 25 - 70 years * have urinary incontinence problem * follow command * informed consent exclusion criteria: * previous surgical correction of ui * use medications for treating overactive bladder symptoms * impaired recent and/or recall memory * brain and/or spinal cord lesion * untreated urinary tract infection * anal lesion which contradicted for inserting instrument * prolapsed rectum * prolapsed uterus * history of pelvic injury * pregnancy

Keywords: urinary incontinence, pelvic floor muscle training
a single centre study to compare the efficacy and safety of femtosecond laser-assisted versus manual cataract surgery

Conditions: Cataract

Summary: this clinical study is a controlled, open, prospective, single-centre, multi-surgeon eye study to determine the safety and efficacy of intraocular cuts for femtosecond laser assisted lens frag-mentation to support phacoemulsification of the cataractous lens prior to iol implantation. the cuts are applied by means of the femtec femtosecond laser system with the customlens soft-ware module using a cylindrical and radial cut pattern with diameter and height dependent on anterior chamber depth, pupil diameter and ocular lens size. the hypothesis of the study is that by means of femtosecond laser assisted lens fragmentation the required ultrasound energy used for phacoemulsification can be reduced in a safe and effective way.


Eligibility criteria:
inclusion criteria: * clear corneal media * patients must be at least 18 years of age. exclusion criteria: * on a keratometric map of the cornea, the minimal and maximal k-values of the central 3mm zone must not differ by more than 5 dioptres. (exclusion criterium for group a only) * the maximum k- value may not exceed 60 d, the minimal value may not be smaller than 37 d. (exclusion criterium for group a only) * corneal disease or pathology that precludes transmission of laser wavelength or distortion of laser light. (exclusion criterium for group a only) * subjects with a poorly dilating pupil or other defect of the pupil that prevents the iris from adequate retraction peripherally. * lens/zonular instability such as, but not restricted to, marfan's syndrome, pseudoexfoliation syndrome, etc. * previous intraocular or corneal surgery of any kind, including any type of surgery for either refractive or therapeutic purposes in either eye. * known sensitivity to planned concomitant medications. * patients with disorders of the ocular muscle, such as nystagmus or strabismus * keratoconus * patients with woundhealing disorders such as connective tissue disease, autoimmune illnesses, immunodeficiency illnesses, ocular herpes zoster or simplex, endocrine diseases, lupus, rheumatoid arthritis * abnormal examination results from slit lamp, fundus, iol master * abnormal examination results from orbscan (exclusion criterium for group a only) * patients with an autoimmune disease, collagenosis or clinically significant atopy. * patients who are pregnant or nursing. * patients who do not give informed consent. * acd \ 4.5 mm as measured by ultrasonic examination (exclusion criterium for group a only)

Keywords: lens fragmentation cataract phacoemulsification femtosecond laser
long-term safety in atrial fibrillation patients

Conditions: Persistent or Permanent Nonvalvular Atrial Fibrillation

Summary: the purpose of this study is to provide safety and tolerability data for azd0837 during long-term treatment (5 years) in patients with non-valvular atrial fibrillation (af) and one or more additional risk factors for stroke and systemic embolic events (moderate to high risk patients).


Eligibility criteria:
inclusion criteria: * patients with paroxysmal, persistent or permanent non valvular atrial fibrillation with one or more additional risk factors for stroke and systemic embolic event * completing treatment with study drug in d1250c00008. exclusion criteria: * atrial fibrillation secondary to reversible disorders, eg hyperthyroidism * presence of a valvular heart disease, mechanical heart valves, active endocarditis, left ventricular aneurysm or thrombus, atrial myxoma or any condition other than atrial fibrillation requiring chronic anticoagulation treatment * myocardial infarction, heart surgery or percutaneous coronary intervention (pci) within the previous three months prior to inclusion; stroke and/or systemic embolism within the previous 30 days prior to inclusion * conditions associated with increased risk of major bleeding.
inhaled ivermectin and covid-19

Conditions: COVID-19

Summary: coronavirus disease-19 is global healthcare crisis. till may 20, 2020, there were approximately 4,789,205 cases and 318,789 related mortalities were identified globally. this dramatic situation led to healthcare service collapse in many countries. each country developed its own action plan depending on healthcare expertise and the available resources. there is no definitive therapy for coronavirus disease-19 up till now. many current and investigational drugs are used nowadays. recent reports suggest a beneficial role of ivermectin in the management of coronavirus disease-19. a notice that necessitates further clinical studies. the aim of this study is to assess the efficacy and safety of the usage of inhaled ivermectin in the management of coronavirus disease-19.

coronavirus disease-19 (covid-19) is a pandemic disease which is caused by the sars-cov2 virus. it is one of the biggest single-stranded rna viruses. sars-cov2 viral polyproteins are responsible for viral replication and transcription while its protease enzymes are responsible for polypeptides cleaving and immune system blockage. they are considered to be an important therapeutic target. host immunological response against sars-cov2 could affect the disease outcome. patients requiring icu admission have higher levels of interleukins 6 - 10, tumor necrosis factor α (tnf-α), and fewer cd4+ and cd8+ t cells. the level of cytokines and lymphopenia is associated with pulmonary damage and respiratory distress. till now, there is no definitive therapy for covid-19. multiple current and investigational drugs are used such as hydroxychloroquine, lopinavir/ritonavir, and remdesivir. ivermectin: a potent anti-parasitic drug has shown to have an in-vitro antiviral activity against a broad range of viruses. it inhibits the interaction between the human immunodeficiency virus-1 (hiv-1) integrase protein (in) and the importin (imp) α/β1. but on the other hand, ivermectin showed limited efficacy against denv in phase iii clinical trial that was done in thailand in 2014-2017. recent studies proved the in-vitro effect and "subsequently" the possible therapeutic role of ivermectin in the management of sars-cov2.

Eligibility criteria:
inclusion criteria: * both sexes * age above 18 * test positive for covid-19 using reverse transcription polymerase chain reaction (rt-pcr) prior to the start of study. * willing to participate in the study * mild to moderate severity index according to the who criteria exclusion criteria: * hypersensitivity to the study drug. * history of co-morbid conditions such as: uncontrolled hypertension and diabetes, retinal problems and chronic liver and renal disease. * women who are pregnant or breastfeeding.

Keywords: covid ivermectin inhalation antiviral safety
cognitive-motor dual task training in patients with multiple sclerosis

Conditions: Multiple Sclerosis; Cognitive Impairment; Motor Disorders

Summary: clinical features of multiple sclerosis (ms) vary widely from patient to other. about the 60% of patients with ms presents cognitive deficits associated with motor disability. the principal consequences of the motor disabilities concern difficult in gait and balance. the principal cognitive deficits concern the speed in elaborating information, the complex attention and the memory. during walking in daily life, it is often required to turn the head for looking something happening in the surrounding environment, for example when a sudden noise is heard, while crossing the street, when there's something interesting around or when is required to verbally answer to someone without stopping walking. all these examples are referred to a common daily life mechanism that has been defined as dual task (dt). considering that the attention is a limited function, divide it in two different and simultaneous tasks (motor and cognitive), cause a cognitive-motor interference (cmi) that lead to a loss of efficacy in one or in both the tasks. the main aim of the study is to verify the impact of a brief rehabilitation training that combining motor and cognitive therapy using a dual-task paradigm, on balance and gait in ms patients, compared with the traditional therapies that provide a specific postural stability rehabilitation approach. recruited patients will be randomized in two different groups which perform two different training. each group perform the allocated training 3 times a week for 4 weeks. all the patients will be evaluated at the baseline (t0), at the end of the training (t1) and 60 days after the end of the training (t2).


Eligibility criteria:
inclusion criteria: * diagnosis of ms according with revisited mcdonalds criteria; * expanded disability status scale (edss) ranging between 0 and 6; * ability to walk independently or with aid for at least 50 meters. exclusion criteria: * associated psychiatric and/or neurological disorders (different from the ms); * clinical relapse within the three months prior to enrollment; * steroid therapy within 30 days before the enrollment; * peripheric diseases as visual and/or auditory impairments that could interfere with motor and cognitive tasks execution; * fracture of lower limb within three months before the enrollment.
epiretinal membrane and pseudophakic cystoid macular edema

Conditions: Macular Edema; Epiretinal Membrane

Summary: prospective, observational cohort study evaluating the association between pre-surgical existence of an epiretinal membrane (erm) and the development of pseudophakic cystoid macular edema (pcme) using spectral domain optical coherence tomography (oct) measurements.


Eligibility criteria:
inclusion criteria: * 18 years or older * cataract surgery patients exclusion criteria: * pre-existing macular edema * choroidal neovascularization * uveitis * age-related macular degeneration * myopia \> 6 diopters * proliferative diabetic retinopathy * diabetics retinopathy great than mild in serverity
duration of protection of nirsevimab against hospitalisation for respiratory syncytial virus infection

Conditions: Respiratory Syncytial Viral (RSV) Infections

Summary: respiratory syncytial virus (rsv) is a leading cause of hospitalizations for acute lower respiratory tract infection (lrti) in infants. in australia approximately 1.5% of infants are hospitalized due to rsv, 80% of whom are born full-term and are otherwise healthy. two randomized trials have used a seasonal implementation strategy to show nirsevimab, a long-acting monoclonal antibody, has sustained efficacy against rsv lrti hospitalizations in the first 150-180 days after administration. nirsevimab has been approved in many countries for the prevention of rsv-lrti in neonates and infants. however, the protection offered by nirsevimab beyond 180 days remains unknown. queensland is a large australian state spanning the tropical and sub-tropical climate zones, where rsv circulates year-round. the queensland government publicly funded nirsevimab for all infants at birth from 15 april 2024. the aim of this study is to estimate the duration of effectiveness of nirsevimab against rsv-related hospitalizations. a case-control study will be conducted using routinely collected linked data. cases will be children born in queensland from 15 april 2024 to 14 april 2025 who are hospitalised with an rsv-related condition prior to 14 april 2026. controls will be drawn from the set of infants who are admitted to the same hospital in a 5:1 ratio, and matched on age and sex using the queensland perinatal data collection. nirsevimab receipt will be extracted from hospital's electronic medical records and linked to hospitalization data by the queensland health data linkage unit. duration of protection against rsv-related hospitalisation due to nirsevimab will be assessed using multivariable logistic regression model accounting for matching and adjusting for confounding variables. this case-control study will determine the level and duration of protection offered by nirsevimab in a region with year-round rsv circulation and inform future prevention strategies. interim analysis is expected to be available at the time of the conference, allowing for early dissemination of this first evidence about nirsevimab duration of protection beyond 180 days. funding: from sanofi and astrazeneca through a collaboration grant.


Eligibility criteria:
inclusion criteria: any infant born between 15 april 2024 and 30 april 2025 and hospitalized for any reason between 15 april 2024 and 30 april 2026. exclusion criteria: infants who admitted to hospitals with an elective admission. ((i.e. admissions that are planned ahead of time, such as scheduled surgeries or other pre-arranged medical procedures).

Keywords: respiratory syncytial virus case control monoclonal antibody nirsevimab
evaluation of the analgesic efficacy of multimodal pain control regimens that aim to limit the use of narcotics in cholecystectomy and hernia repairs

Conditions: Acute Pain

Summary: subjects were patients of the five surgeons with surgical associates of mansfield (sam) who underwent an elective or urgent laparoscopic cholecystectomy; or elective or urgent laparoscopic or open hernia repair (inguinal, ventral, or umbilical); and who otherwise met the inclusion criteria. i

this performance improvement study is a retrospective review of data obtained from patients at methodist mansfield medical center (mmmc) in mansfield, texas from may 1, 2022 to september 30, 2022. subjects were patients of the five surgeons with surgical associates of mansfield (sam) who underwent an elective or urgent laparoscopic cholecystectomy; or elective or urgent laparoscopic or open hernia repair (inguinal, ventral, or umbilical); and who otherwise met the inclusion criteria. incisional hernias were excluded. emergent hernia operations that required bowel or colon resections due to strangulation were excluded

Eligibility criteria:
inclusion criteria: patients of the five physicians of the sam group patients ≥18 years patients undergoing urgent or elective laparoscopic and robotic cholecystectomy or patients undergoing urgent or elective laparoscopic, robotic or open hernia repair (ventral, umbilical, or inguinal). exclusion criteria: patients \<18 years patients with chronic pain conditions managed with chronic use of narcotics patients that underwent incisional hernia repairs patients that underwent complicated hernia repairs that included other operations such as colon and bowel resection procedures
fever education given to parents of children presenting to the emergency department with fever

Conditions: Fever

Summary: fever is a common symptom of childhood, especially between the ages of one and five, and is the main reason for emergency room visits. these emergency room visits are due to parents incorrect information and practices regarding fever management. this situation causes an increase in parental anxiety and failure to provide fever management. in line with this information, this study was planned to evaluate the effects of education given to parents of children presenting to the emergency room with fever on parental anxiety level and fever management.

fever is a common symptom in childhood and is the main reason for emergency room visits. the rate of children applying to the emergency department due to fever in our country is quite high compared to the rest of the world. parents misinformation and practices regarding fever increase parental anxiety levels and negatively affect fever management. interventional studies aimed at reducing parents anxiety levels and ensuring fever management are quite limited. this research will evaluate the effect of fever education given to parents on their anxiety levels and fever management. the research was planned as a randomized controlled study with experimental and control groups. the research will be carried out between april 2024 and april 2025. after the power analysis of the sample, a total of 80 people will be included in the sample, 40 in the experimental group and 40 in the control group. parents in the experimental group will be given fever training, while parents in the control group will not receive any treatment. data will be collected with parent-child introductory information form, state anxiety scale, parent fever management scale, visual analogue scale (vas)- satisfaction with fever education practice scale and parent-education satisfaction form scale. the data will be pre-tested, post-tested 1 month after the training, and permanence tested 3 months after the training, and the research will be terminated. generalised linear models analysis, robust anova, independent samples t test, mann whitney u and chi-square analysis will be used in the evaluation of the data. mean, s.deviation, median, minimum and maximum will be used for quantitative data and frequency and percentage will be used for categorical data.as a result of the research, it is expected that fever education given to parents will positively affect parental anxiety level and fever management.

Eligibility criteria:
inclusion criteria: * having a child between the ages of 1-5 * able to read, understand and have no problems speaking turkish * having a green triage code in the emergency room triage application exclusion criteria: * children diagnosed with or receiving treatment for chronic diseases * children with a history of febrile convulsions * children dependent on home mechanical ventilation * parents with psychiatric diagnoses will be excluded from the study

Keywords: emergency fever parents education child anxiety
the genetics of pulmonary fibrosis

Conditions: Idiopathic Pulmonary Fibrosis (IPF)

Summary: this study seeks to screen first degree family members of people with idiopathic pulmonary fibrosis (ipf) for the earliest signs of lung fibrosis.

the purpose of this study is to explore genetic factors associated with the development of pulmonary fibrosis. the investigators aim is to identify and explore genetic loci that affect development of pulmonary fibrosis and also explore related environmental exposures. idiopathic pulmonary fibrosis (ipf) is one of the interstitial lung diseases under the broader umbrella of idiopathic interstitial pneumonias (iip). the investigators hypothesize that inherited genetic factors are associated with pulmonary fibrosis. to investigate the genetics of pulmonary fibrosis, the investigators plan to enroll individuals with pulmonary fibrosis and their family members.

Eligibility criteria:
inclusion criteria: * age at least 18 years old * family member diagnosed with ipf exclusion criteria: - no family member with ipf