Kornimate/medical-research-clean huggingface dataset:
using social media to improve art retention and treatment outcomes among ylhiv in nigeria

Conditions: Human Immunodeficiency Virus

Summary: a randomized control trial to test the effectiveness of a structured online support group, smart (social media to improve art retention in treatment) connections, to improve retention in hiv care services among youth living with hiv (ylhiv) in nigeria.

study aim is to examine the effect of an online structured support group intervention (smart connections) designed to improve retention in hiv care services among youth ages 15-21 years living with hiv enrolled in art services. a randomized control trial in which youth living with hiv (ylhiv) will be allocated to standard of care (control) or standard of care plus an online support group and followed for 12 months. structured questionnaires will be administered to participants at baseline, 6 and 12 months. clinical data will also be extracted on participants. in-depth interviews with a subset of participants and intervention implementers will be completed at the end of the intervention period. although participants will be recruited from health facilities, the intervention is conducted "virtually," by trained facilitators, not within the health facilities.

Eligibility criteria:
inclusion criteria: * hiv positive and know their status * actively on art for less than 12 months, including newly initiating patients * age 15 to 24 years * can demonstrate basic literacy necessary to participate in online chats exclusion criteria: * unable to attend the initial intervention group meeting for treatment participants * currently enrolled in another research study related to hiv service retention or art adherence * critically or severely ill requiring hospitalization or such that the individual is unable to provide informed consent at the time of study recruitment

Keywords: hiv youth social support social media retention
comparison of circulating tumor dna and tumor tissue dna by targeted sequencing in non-small cell lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: conduct a prospective study to compare gene detection by ctdna with tumor tissue dna via targeted dna sequencing in surgical nsclc patients.

previous studies have shown the feasibility of detecting mutation status by circulating tumor dna (ctdna)in non-small cell lung cancer (nsclc) patients. however, no clinical standard method has been established, and most previous studies were lack of prospective clinical data and aimed at advanced nsclc. we plan to perform a prospective study including consecutive cases of nsclc patients who underwent surgical treatments. primary tumor and plasma samples were collected in each patients and gene mutation analysis were performed immediately after surgery. we utilized the targeted dna sequencing with a next-generation sequencing (ngs) platform to detect driver somatic mutations in matched tumor dna (tdna) and plasma ctdna samples with matched white blood cell (wbc) dna as a control. a panel of genes were identified.

Eligibility criteria:
inclusion criteria: * patient who is confirmed primary lung cancer by frozen pathologic histology * both the fresh tissue tumor and plasma samples are collected for analysis exclusion criteria: * patients who received any treatment prior to resection * patients who have a history of malignancy * paraffin embedded section confirmed small cell lung cancer or unclassified carcinoma * tumor specimens where insufficient dna

Keywords: circulating tumor dna lung cancer targeted sequencing
ent fiberlase co2 study

Conditions: Laryngeal Diseases; Pharyngeal Diseases

Summary: this study is intended to collect data regarding treatment with a new flexible fiber used to transmit laser emitted from a carbon dioxide (co2) laser to the transoral region. this study will include a single treatment that is performed transorally (through the mouth) for oral or laryngeal indications in the field of ear, nose and throate (ent).


Eligibility criteria:
inclusion criteria: 1. general good health allowing patient to undergo general anaesthesia or heavy sedation according to the specific procedure. 2. adult 3. able and willing to comply with all visit, treatment and evaluation schedule and requirements 4. able to understand and provide written informed consent 5. disease which requires tissue ablation for treatment exclusion criteria: 1. having a bleeding disorder or taking anticoagulation medications, including heavy use of aspirin, in a manner which does not allow for a minimum 10 day washout period prior to each treatment (as per the patient's physician discretion); 2. significant concurrent illness, such as uncontrolled diabetes i.e. any disease state that in the opinion of the physician would interfere with the anesthesia, treatment, or healing process 3. mentally incompetent, prisoner or evidence of active substance or alcohol abuse; 4. any condition which, in the physician's opinion, would make it unsafe (for the subject or for the study personnel) to treat the subject as part of this research
pharmacokinetics of crd007 in patients with abdominal aorta aneurisms.

Conditions: Abdominal Aortic Aneurisms

Summary: the purpose of the study is to determine the plasma levels of crd007 in patients with abdominal aortic aneurysms after the administration of single doses of tablets containing 10, 25 and 40 mg crd007.


Eligibility criteria:
inclusion criteria: * infra-renal abdominal aortic aneurysm exclusion criteria: * significant concurrent disease or medical conditions that are deemed to interfere with the pharmacokinetics or the safety of crd007 conduct of the trial
vitamin d to improve outcomes by leveraging early treatment: long-term brain outcomes in vitamin d deficient patients

Conditions: Cognitive Decline

Summary: this ancillary study will determine if early administration of a single high-dose (540,000 iu) oral vitamin d3 (cholecalciferol) treatment improves 12-month global cognition and executive function as determined by comprehensive neuropsychological testing in 140 critically ill patients with vitamin d deficiency at enrollment.

violet-bud is an ancillary study to a parent double-blinded, placebo-controlled randomized control trial (rct) evaluating how a single, high-dose (540,000 iu) oral vitamin d3 treatment affects 90-day mortality in patients who are at high risk for ards and have vitamin d deficiency (plasma 25-hydroxyvitamin d \< 20 ng/ml) at enrollment. the parent rct (vitamin d to improve outcomes by leveraging early treatment \[violet\], nct03096314) is part of the clinical trials network for the prevention and early treatment of acute lung injury (petal) sponsored by the nhlbi. the violet trial completed enrollment in july 2018 with 1,360 randomized to either high dose, enteral vitamin d3 or placebo. this ancillary study will provide additional funding to perform comprehensive neuropsychological (cognitive) evaluations, which were not part of the parent trial. these neuropsychological evaluations will be conducted 12 (+/- 4) months after randomization among a subset of 140 survivors enrolled in violet. this ancillary study will conducted in 7 (out of 42) sites.

Eligibility criteria:
inclusion criteria: * patients enrolled in the violet parent study exclusion criteria: * deaf or blind * non-english speaking

Keywords: vitamin d cognitive decline dementia critical care
exploratory study of intermittent hypoxia intervention on colorectal cancer

Conditions: Colorectal Cancer

Summary: this study aims to explore the safety and efficacy of intermittent hypoxia intervention on patients with colorectal cancer.

the hypoxic adaptive response is a form of acquired tolerance that occurs by activating internal cellular protective mechanisms and enhancing immune function.this technology was initially utilized in sports training and high-altitude medicine to enhance strength, endurance, and overall athletic performance, as well as to enhance the body's adaptation to high-altitude hypoxia. this technology was initially utilized in sports training and high-altitude medicine to enhance strength, endurance, and overall athletic performance, as well as to enhance the body's adaptation to high-altitude hypoxia. intermittent hypoxia (ih) refers to periodic hypoxic-normoxic training performed with brief exposure to hypoxia. previous studies have found that short-term intermittent hypoxia can increase the sensitivity of hypoxia and reduce the severity of acute hypoxia injury, and alleviate acute hypoxia injury by reducing the inflammatory response caused by hypoxia. intermittent hypoxia has been shown in our team's work to effectively inhibit colorectal cancer tumor progression in mice by enhancing immune cell function. this study aims to explore the safety and efficacy of ih in patients with colorectal cancer using a non-randomized self-controlled trial.

Eligibility criteria:
inclusion criteria: * patients with colorectal cancer between ages of 18 and 65 years. * colorectal cancer stage ⅰ,ⅱ. * subjects or their legally authorized representative can provide informed consent. exclusion criteria: * history of cardiovascular, cerebrovascular, dermatological, and hematological diseases. * history of pulmonary, hepatic, kidney, dermatologic and hematologic diseases. * history of pregnancy, hypertension, diabetes mellitus, obesity, sleep apnea and neurological disorders. * history of substance abuse. * participating in other drug or medical device studies. * history of organ transplantation, including allogeneic stem cell and immune cell transplantation. * recent severe infection within 4 weeks. * received cancer treatment, including chemotherapy and radiotherapy, within 4 weeks. * underwent major surgery within 28 days.
active controlled trial of chf5993 pressurized metered-dose inhaler ( pmdi) vs symbicort®turbuhaler® in patients with chronic obstructive pulmonary disease ( copd)

Conditions: COPD (Chronic Obstructive Pulmonary Disease)

Summary: the purpose of this study is to demonstrate the superiority of chf 5993 pmdi (fixed combination of extrafine beclometasone dipropionate plus formoterol fumarate plus glycopyrronium bromide) over symbicort® turbuhaler® in terms of pulmonary function, as well as to assess its safety.


Eligibility criteria:
inclusion criteria: * male or female adults aged \> 40 years with a diagnosis of copd * current smokers or ex-smokers * a post-bronchodilator fev1 \< 50% of the predicted normal value and a post-bronchodilator fev1/fvc ratio \< 0.7 at least 10-15 minutes after 4 puffs (4 x 100 µg) of salbutamol pmdi * at least one exacerbation in the 12 months preceding the screening visit exclusion criteria: * pregnant or lactating women * diagnosis of asthma, history of allergic rhinitis or atopy * patients treated for exacerbations in the 4 weeks prior to screening visit * patients treated with non-cardioselective ß-blockers in the month preceding the screening visit * patients treated with long-acting antihistamines unless taken at stable regimen at least 2 months prior to screening and to be maintained constant during the study or if taken as pro re nata * patients requiring long term ( at least 12 hours daily) oxygen therapy for chronic hypoxemia * known respiratory disorders other than copd * patients who have clinically significant cardiovascular condition

Keywords: copd anticholinergics triple combination
external validation of the vexus score for the prediction of acute renal failure in cardiac surgery

Conditions: Renal Failure; Acute Renal Failure; Renal Insufficiency; Acute Renal Insufficiency

Summary: acute renal failure is a frequent complication associated with significant morbidity and mortality in postoperative cardiac surgery. the vexus (venous excess ultrasound grading system) score was created to qualitatively assess this venous congestion, based on ultrasound data from patients obtained post operatively in cardiac surgery. these data included: inferior vena cava diameter, doppler flow of the suprahepatic veins, portal trunk and renal veins. this score is predictive of the onset of acute renal failure in the first 3 days after surgery. the vexus score has not been validated in an external and prospective way in cardiac surgery.

acute renal failure is a frequent complication associated with significant morbidity and mortality in postoperative cardiac surgery. the pathophysiology in this context is complex, poorly understood and the causes are multiple: underlying nephropathy, intra- or postoperative haemodynamic instability, the use of an extracorporeal circulation, inflammation, etc. one of the other possible etiologies is venous congestion. this may be due to volume overload and/or isolated global or right heart dysfunction. early treatment could prevent the onset of arf or reduce its consequences, hence the importance of being able to predict its onset. the vexus (venous excess ultrasound grading system) score was created to qualitatively assess this venous congestion, based on ultrasound data from patients obtained post operatively in cardiac surgery. these data included: inferior vena cava diameter, doppler flow of the suprahepatic veins, portal trunk and renal veins. this score is predictive of the onset of acute renal failure in the first 3 days after surgery. the vexus score has not been validated in an external and prospective way in cardiac surgery.

Eligibility criteria:
inclusion criteria: * scheduled cardiac surgery * affiliated to a social security system exclusion criteria: * emergency surgery * chronic renal failure defined by a glomerular filtration rate of less than 30ml/min or dialysis. * renal transplant recipients * cirrhosis and portal hypertension * setting up a left ventricular assist device implantation * patient under ecmo (extracorporeal membrane oxygenation), intra-aortic balloon pump, or a mechanical circulatory support device such as impella * no available operator to perform ultrasound scans * patients objecting to the use of their data in research * subject under guardianship or subject deprived of freedom * pregnant or breastfeeding women * resume surgery within 48 hours of scheduled surgery * lack of a trained operator to perform d+1 and d+2 ultrasound

Keywords: renal failure cardiac surgery vexus score venous congestion
care companion diabetes

Conditions: Type 2 Diabetes

Summary: digital health interventions have the potential to help patients with diabetes effectively manage their disease at home. many digital health studies provide patients with educational materials and self-care recommendations. the digital health interventions allow patients to conveniently access these materials on their phones or computers, and enable care teams to provide essential knowledge for diabetes management. digital health based education intervention is a reasonably inexpensive method that offers high coverage and motivational encouragement to help patients improve their health at home.this study aims to provide patients with timely education for diabetes management and has the potential to improve clinical outcomes for patients with diabetes.

this study is a prospective, randomized control, pragmatic trial of patients with diabetes, including patients newly diagnosed with diabetes and patients with uncontrolled diabetes. this study focuses on delivering educational materials through the mychart care companion pathway to conduct timely educations and assess patient medication adherence level and activity level. this is a minimal risk study without intervention procedures. there are two type 2 diabetes subjects groups uncontrolled diabetes and new diabetics. each group will be randomized 1 to 1 to either the care companion program or control group which receives a one-page document on diabetic care. the care companion program is a digital interactive weekly program that includes modules on health and nutrition education and weekly activity and medication adherence check-ins. there are weekly modules that are completed over 16 weeks. the objective is to provide timely education to patients with type 2 diabetes through mychart care companion pathway, with the aim of improving patient's self management knowledge. we will also evaluate patient experience and acceptance of the mychart care companion features.

Eligibility criteria:
inclusion criteria: * patients with a new type 2 diabetes diagnosis within 1 year at time of enrollment and has an a1c level over 6.5%, or patients with a type 2 diabetes diagnosis over an year and has an a1c level over 8% at time of enrollment * patient able to speak and understand english * patient is at least 18 years of age exclusion criteria: * patient has cognitive limitations that, in the opinion of their provider, limit the patient's ability to understand study requirements
utility of tissue doppler echocardiography for selecting patients for cardiac resynchronisation therapy

Conditions: Heart Failure

Summary: currently the main selection tool for cardiac resynchronisation therapy (crt) is the qrs duration on the surface echocardiography (ecg) which has been shown to be a poor predictor of response. we sought to evaluate the use of tissue doppler (tdi) assessment of dyssynchrony in prediction of response to crt. the hypothesis is that the presence of mechanical dyssynchrony (measured using tdi echocardiography) successfully identifies heart failure patients who will respond to crt. conversely, the absence of mechanical dyssynchrony is associated with a low/no response to crt. this is a three arm study. group 1 comprises patients with dyssynchrony on tdi who are implanted with a biventricular icd whereas group 2 patients comprise patients who have no dyssynchrony. group 2 patients are randomised 1:1 to either receive a biventricular icd (2a) or an icd (2b). all patients undergo a nyha class assessment, a cardiopulmonary exercise test, and an echocardiogram at baseline and at 6 months follow up. baseline and 6 months findings will be compared in all three groups.


Eligibility criteria:
inclusion criteria: 1. patients must have an indication for icd therapy 2. heart failure of any aetiology with evidence of left ventricular (lv) systolic dysfunction with lv ejection fraction \ 55 mm) 3. nyha class iii/iv symptoms of heart failure despite optimal medical therapy 4. qrs duration ≥120ms exclusion criteria: 1. reversible cause of heart failure such as ongoing ischaemia amenable to revascularisation or treatable valvular disease 2. requirement for ventricular pacing due to atrioventricular block. 3. limited life expectancy (\< 6 months)

Keywords: cardiac resynchronisation therapy tissue doppler imaging dyssynchrony
effect of lavender oil inhalation in colonoscopy patients

Conditions: Colonic Disease

Summary: aim: in this study, it was aimed to determine the effect of lavender oil inhalation on the anxiety and comfort levels of patients who will undergo colonoscopy. material and method: in this randomized controlled, prospective study, 73 experimental and 72 control group patients who will experience colonoscopy in a training and research hospital in western turkey were included. while lavender inhalation was applied to the patients in the experimental group, routine care was applied to the patients in the control group. the short-form state-trait anxiety scale and general comfort scale were used to collect data before and after the procedure. p\<0.05 level was considered statistically significant.

colonoscopy is a painful and uncomfortable procedure, and patients experience anxiety and restlessness / tension before colonoscopy. it is stated that aromatherapy, which is a non-invasive method and easy to apply, can be used to reduce these negative effects. it is known that the fastest and easiest way of entry of essential oils into the body is inhalation. in addition, it is stated that it is safe to carry out these applications by inhalation; for this reason, studies are mostly carried out by inhalation of essential oils. in studies conducted in different fields, it is seen that lavender has positive effects on variables such as anxiety, pain, insomnia, comfort and vital signs. looking at the literature; more music therapy and education are applied to patients who will experience anxiety and loss of comfort due to colonoscopy; as for aromatherapy interventions; in a study conducted in 2017 with sunflower and neroli (orange flower) oil, olive flower oil (osmanthus fragrans) and grapefruit oil were used. in this study, it was aimed to determine the effect of lavender essential oil, which has been found to have positive effects on many variables in various studies, on the anxiety and comfort levels that may be experienced in patients who will experience colonoscopy.

Eligibility criteria:
inclusion criteria: * over 18 years old, 65 years old and under, * having colonoscopy, * not having the risk of heart failure and cardiogenic shock (class iii and iv), * not having a history of asthma, eczema, and allergies to flowers and plants, * not allergic to lavender, * not having communicative/severe hearing or speech impairment, * not using antidepressant, antihistamine, diuretic, hypnotic, benzodiazepine and narcotic derivatives * having stable vital signs * individuals who volunteered to participate in research exclusion criteria: - individuals who do not meet the inclusion criteria

Keywords: colonoscopy aromatherapy anxiety comfort lavander oil