Kornimate/medical-research-clean huggingface dataset:
nitrous oxyde misuse among teenagers consulting in an addictology center dedicated to young drug users in montpellier

Conditions: Nitrous Oxide; Drug Abuse

Summary: nitrous oxide gas is used in several application areas : medical as an anesthetic drug ; in food industry as a foaming and a mixing agent ; industrial to speed combustion. it is also misused for its hilarant, euphoric and hallucinogenic effect. for this purpose the gas is transfered in a balloon to be inhaled. as its effects are briefs, its consumption is often perseived as safe. however, some risks exist and are majorated by the way of use and for some groups of people. since 2016, the french observatory of drug and substances addiction (ofdt) describes an increasing misuse of nitrous oxide amoung teenagers and young adults. in november 2019, a french press release alerts on the recent increasing of neurologic side effects related to the misuse of nitrous oxide. that's why, it seems to be interesting to improve the screening of nitrous oxide abuse, in particular amoung adolescents and young adults. in our study, the investigators would like to determine the characteristics (social, medical, any drug abuse) of teenagers and young adults who misuse nitrous oxide. through a questionnaire, the investigators plan to select teenagers and young adults who consult in an addictology center dedicated to young drug consumers in montpellier. this questionnaire is anonymous. the data will be collected only after obtaining the patient's agreement. the final goal is to create a tool to help general practitioners in screening young people at risk of nitrous oxyde misuse.


Eligibility criteria:
inclusion criteria: - teenagers and young adults consulting in an addictology center dedicated to young abusers in montpellier and who agree with being included in the study exclusion criteria: - to refuse to participate to the study

Keywords: screening spotting
cerebrospinal fluid biomarkers for brain tumors

Conditions: Central Nervous System Neoplasm

Summary: this study examines cerebrospinal biomarkers in patients with brain tumors. a biomarker is a measurable indicator of the severity or presence of your disease state. collecting and storing samples of cerebrospinal fluid from patients with brain tumors to study in the laboratory may help doctors develop new strategies to better diagnose, monitor, and treat brain tumors.

primary objective: i. to collect cerebrospinal fluid (csf) samples that can provide a resource to the research community for biomarker discovery in patients with gliomas. secondary objective: i. evaluate the feasibility of serial csf sampling from patients with brain tumors for longitudinal evaluation of tumor biomarkers. outline: patients undergo collection of csf samples via lumbar puncture at least 2 times. patients may undergo additional collection of additional csf samples if they choose. after completion of study treatment, patients are followed up periodically.

Eligibility criteria:
inclusion criteria: * any evidence of neoplasm involving the central nervous system (cns) or its adjacent structures in contact with csf. such lesions may include but are not limited to intra-axial or extra-axial lesions, which could be benign, malignant or as yet undefined, involving the brain, spine, meninges, nerves, or vasculature or supporting structures * subjects must be 18 years of age or older exclusion criteria: * patients who are under 18 years of age or are a member of a vulnerable population will be excluded from this study * pregnant women or women who may be pregnant are specifically excluded from study participation * exception will be granted for patients with diminished capacity to consent if a legally authorized representative is available * patients without clinical or radiographic evidence of a potentially neoplastic cns lesion will be excluded * patients with an inability or unwillingness of individual or legal guardian/representative to give written informed consent will be excluded * any patient for whom a clinical contraindication exists to the intended route of csf access will be excluded. for example, a patient with a large posterior fossa mass lesion at risk of herniation, or a patient with coagulopathy, or other contraindication to lumbar puncture would not be eligible to participate via use of lumbar puncture for csf access
rectal temperature measurement in detecting hypothermia during hip arthroscopy

Conditions: Hip Arthropathy; Hypothermia; Orthopedic Disorder

Summary: irrigation fluids used during hip arthroscopy surgery are generally stored at room temperature and are cooler than the core temperature of the patient. they are used abundantly during hip arthroscopy surgery. the aim of this study is to detect local and then general hypothermia that may occur by monitoring the body temperature from the rectal mucosa of patients undergoing hip arthroscopy, using irrigation fluids of different temperatures and comparing it with the temperature measured from the temporal region.

this is a prospective randomized controlled study where sequential randomization will be applied to patients; the first patient will be included in the 1st group, and the second patient will be included into the 2nd group, and so on. all patients scheduled for hip arthroscopy in our institution during the defined study period are eligible for inclusion. while room temperature irrigation fluids will be used routinely for group 1, irrigation fluids heated up to 36-38 degrees will be used for the other group. patients will be operated in the same operating room and at the same room temperature with the same type/amount of covering and body warming. at the start of the surgical procedure, a probe inserted into the rectal mucosa will measure the patient's body temperature every 15 minutes. in addition, the temperature of the patients will be measured from their temporal regions with a contactless thermometer, whose batteries will be changed every two operations. the data obtained will be analyzed by a blinded researcher. mean body temperatures measured from 2 different locations (temporal region and rectal mucosa) between the groups will be compared, and the probability of detecting early local and later general hypothermia from the rectal mucosa will be examined.

Eligibility criteria:
inclusion criteria: - patients between the ages of 18-50 undergoing hip arthroscopy and willing to participate exclusion criteria: * patients with a previous history of surgery from the same hip * patients with a history of thyroid disease (hypo/hyperthyroidism)

Keywords: femoroacetabular impingement hip arthroscopy hypothermia rectal temperature
septorhinoplasty post-operative pain control with spg nerve block

Conditions: Deviated Nasal Septum

Summary: maxillary nerve blocks have been shown to significantly reduce post-operative pain and analgesic intake during the 24-hour period following sinus surgery. this randomized, double-blinded, placebo-controlled study will investigate blocks of the pterygopalatine fossa using a suprazygomatic approach during septorhinoplasty surgery. it is the investigator's hypothesis that this technique will result in decreased post-operative pain and opioid use, and the morbidity associated with it.


Eligibility criteria:
inclusion criteria: * patient presenting for open or endoscopic septorhinoplasty * age 18-80 * normal oral food and water intake before surgery * asa physical classification 1-3 exclusion criteria: * refusal to consent * patients without a cellular phone or who are unable to accept text messages * allergy to opioid narcotics * asa physical classification of 4 or higher * patient requires other surgery in addition to septorhinoplasty * age \> 80 or \<18 * any underlying chronic pain condition or ongoing opioid use over the preceding 3 months * presence of any other factor which, at the discretion of any member of the study team, makes the patient a poor candidate for block placement. * presence of any other factor which, at the discretion of any member of the study team, makes the patient a poor candidate for research participation. * pregnant women

Keywords: post-op pain septorhinoplasty deviated septum
improving outcomes in underserved women with gdm

Conditions: Diabetes Mellitus; Pregnancy

Summary: our objective is to test an innovative approach to improve outcomes among underserved women with gestational diabetes. we ill utilize a multi-lingual, interactive voice response (ivr) -enabled telephone system to facilitate diabetes control and thereby improve pregnancy outcomes. our hypothesis is that telemonitoring will improve maternal glycemia, thereby reducing infant birth weights and leading to improved pregnancy outcomes.

using a step care design, women will be randomized into standard of care or telemonitoring. in the standard of care group, women will monitor their blood glucose levels four times a day, perform fetal movement counting three times a day and also record insulin doses. the women will record this information in a logbook, which will be reviewed by the medical team at prenatal visits. in the telemonitoring group, women will receive the standard of care anmd will also transmit their blood glucose and fetal movement information to their health care providers.

Eligibility criteria:
inclusion criteria: * diagnosis of gdm * 33 or less weeks gestation exclusion criteria: * multiple gestations * history of glucose intolerance outside of pregnancy

Keywords: gdm, pregnancy, macrosomia
antihyperlipidemic effects of oyster mushrooms

Conditions: HIV Infections; Hyperlipidemia

Summary: the primary goal of this study is to evaluate the short-term safety and potential efficacy of oyster mushrooms (pleurotus ostreatus) for treatment of hyperlipidemia in hiv-infected patients who are taking kaletra, a protease inhibitor (pi) that is commonly used in highly active antiretroviral therapy (haart).

this is a single-arm, open-label, 8-week "proof of concept" pilot study in 20 subjects to determine if there are detectable lipid-lowering effects of oyster mushrooms in patients with hiv and hyperlipidemia who are taking kaletra (a ritonavir-containing haart regimen). the study will also assess whether the concurrent administration of oyster mushrooms and such regimens is safe, and investigate the mechanism of action whereby oyster mushrooms may exert their antihyperlipidemic effect.

Eligibility criteria:
inclusion criteria: * documented hiv infection (positive elisa and western blot or measurable plasma hiv rna). * taking kaletra (ritonavir/lopinavir), a ritonavir-containing antiretroviral therapy, for at least 12 weeks * elevated non-hdl cholesterol \>= 160 mg/dl as defined by the national cholesterol education program guidelines (within 30 days of enrollment) * ast or alt \<2.5 times the upper limit of normal (uln) within 30 days of study entry. exclusion criteria: * currently receiving antihyperlipidemic treatment (e.g., statins, fibrates, bile sequestrants, niacin) * pregnancy or breastfeeding * documented history of myopathy or myalgias on hmg-coa reductase inhibitors * documented history of rhabdomyolysis * documented diagnosis of diabetes mellitus * any condition that, in the judgment of the investigator, precludes successful participation in the study.

Keywords: highly active antiretroviral therapy (haart) ritonavir oyster mushrooms non-hdl cholesterol complementary therapies treatment experienced
optimal dog visits

Conditions: Dementia; Aging

Summary: the aim of this project is to study how an the intensity of dog contact during dog visits in nursing homes can affect the immediate response to, and the general effect of the visits, and whether the residents' level of cognitive impairment affects the response and benefit of dog visits. the participants are randomly assigned to receive one type of visits (12 visits in total) out of three possible visit types (1: visit with a dog; 2: visit with a dog, including a planned activity, 3 visit without a dog, including a planned activity). the residents received 2 visits per week for 6 weeks. the behaviour of the participants during visits is recorded. before and after the intervention period, participants are scores on psychometric scales for cognitive impairment level, daily function level and symptoms of depression.


Eligibility criteria:
inclusion criteria: • being able to sit up during the visits exclusion criteria: * dog allergy * fear of dogs * health problems that make participation unadvisable

Keywords: animal-assisted therapy visiting dog non-pharmacological nursing home
pharmacokinetics and pharmacodynamics of biphasic insulin aspart 30 and 50 in subjects with type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in japan. the aim of this trial is to investigate the pharmacokinetics and pharmacodynamics of biphasic insulin aspart 30 (nn-x14mix30) and biphasic insulin aspart 50 (nn-x14mix5050) in subjects with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * duration of diabetes for at least 1 year * body mass index (bmi) maximum 30.0 kg/m\^2 * hba1c maximum 10.0% exclusion criteria: * recurrent severe hypoglycaemia * proliferative or preproliferative retinopathy diagnosed within the last 12 weeks or laser therapy for retinopathy within the last 12 weeks * impaired hepatic function * impaired renal function * cardiac problems * uncontrolled treated / untreated hypertension * hepatitis b surface antigen, hepatitis c antibodies or hiv (human immunodeficiency virus) antibodies positive * total daily insulin dose exceeding 40 iu * treatment with ohas (oral hypoglycaemic agents) or insulin preparations twice or more frequently a day * treatment with ohas or insulin preparations once a day later than noon * subjects who smoke more than 15 cigarettes per day
perioperative eeg-monitoring and emergence delirium in children

Conditions: Delirium

Summary: emergence delirium is a significant problem, particularly in children. however the incidence, preventative strategies, and management of emergence delirium remain unclear. multichannel electroencephalogram is a recognized tool for identifying neurophysiologic states during anesthesia, sleep, and arousal. the aim of the current study is to evaluate the mechanisms and predictors of emergence delirium in children under 16 years scheduled for elective surgery using electroencephalogram. the "pediatric anesthesia emergence delirium scores (paed score)" (sikich et al. 2004) is used to screen for the occurrence of emergence delirium in the post anesthesia care unit.


Eligibility criteria:
inclusion criteria: 1. male or female children aged under 16 years 2. planned elective surgery 3. informed consent by parents or legal guardians exclusion criteria: 1. history of neurological or psychiatric disease 2. delayed development 3. inability of the parents or legal guardians to speak or read chinese 4. participation in another prospective interventional clinical study during this study
effect of radiation and its timing on breast reconstruction in chinese patients

Conditions: Breast Cancer

Summary: the purpose of the study is to investigate the impacts of radiation and the timing of radiation on autologous and prosthetic-based breast reconstruction in chinese post-mastectomy breast cancer patients. the study aims to optimize the timing for autologous/prosthetic breast reconstruction which delivers the best aesthetic results while maintains low complication rate and best integrates into the comprehensive breast cancer treatment. the study is open to all female breast cancer patients undergoing breast reconstruction in the department of breast reconstruction in tianjin medical university cancer institute and hospital.

in breast cancer patients, post-operative radiation therapy is an important component in breast cancer management. however, in the context of breast reconstruction, radiation can have adverse effect as it increases the rate of fat necrosis and leads to fibrosis/ capsular contracture in the reconstructed breast mounds. it is therefore necessary to investigate the best timing for breast reconstruction, especially in those patients which post-operative radiation is required, which does not interfere with overall breast cancer treatment while produces the best surgical, aesthetic and psychological outcome. most studies in this field are retrospective, and studies on chinese cohort are also rare. this multi-center prospectively designed clinical trial will include several medical centers across china. the investigators will allocate the patients into three arms based on the status and sequence of radiation and breast reconstruction, and will further stratify the groups based on the different approaches of reconstruction (autologous/ prosthetic based). both objective and subjective (patient oriented) methods will be employed to make evaluations involving surgical, aesthetic, and psychological outcomes.

Eligibility criteria:
inclusion criteria: * diagnosed with breast cancer * karnofsky performance status (kps) larger than 70 * underwent autologous or prosthetic based breast reconstruction * no severe deficiency in hematological, cardiovascular system, no immune-deficiency, no severe abnormal liver or kidney function. exclusion criteria: * metastatic breast cancer * local recurrence after mastectomy * prior radiation history to chest wall due to other tumors * radiation performed more than 6 months after mastectomy * interruption of radiation more than 2 weeks * gravida or during lactation * concurrently undergoing psychotic disorders

Keywords: breast reconstruction chinese radiation timing
a trial examining the treatment of common warts with combination liquid nitrogen (ln2) and cantharidin

Conditions: Verruca Vulgaris

Summary: the purpose of the study was to see if liquid nitrogen, a commonly used treatment for warts, is more effective if it is used alone, or if it is more effective if combined with cantharidin, a topical treatment also commonly used for warts (verruca vulgaris).


Eligibility criteria:
inclusion criteria: 1. common warts on non-genital, non-facial skin 2. otherwise healthy 3. between 18-65 and able to give informed consent 4. capable of tolerating treatment exclusion criteria: 1. ill-health 2. poor tolerance or sensitivity to treatments in study 3. \ 65 years old 4. verruca plana or condyloma acuminata 5. immunosuppression or immune dysfunction 6. significant peripheral vascular disease 7. significant sensitivity to cold 8. epidermodysplasia verruciformis 9. mosaiform warts or periungual warts

Keywords: warts verruca vulgaris liquid nitrogen cantharidin combination treatment
prevention of insomnia in at-risk youth

Conditions: Insomnia

Summary: this study aims to conduct a randomized controlled trial in comparing cognitive behavioral insomnia prevention program with the active control group in youths who are at risk of insomnia. the results of this study will allow us to take this potential efficacious prevention program to scale and reduce the associated burden of insomnia in the future.

adolescence is a vulnerable period for the emergence of insomnia, which affects more than 10% of the youths (approximately 40% if based on symptoms). insomnia in youths tends to run a protracted course and is associated with numerous negative outcomes including poor quality of life, cognitive and academic impairment, and predisposing to development of depression and anxiety. the burden arises from insomnia has been increasingly recognized worldwide as a debilitating and costly public health concern. however, insomnia in youths is often ignored and under-treated, with only 10% of the local youths recognized their insomnia problem and none of them has received the recommended first-line treatment - cognitive behavioral therapy for insomnia (cbt-i). given the high prevalence, chronicity and long-lasting health-related consequences of insomnia, together with the delay and limited help-seeking behavior, it calls the urgent need for early insomnia prevention and intervention in this vulnerable population. thus, this study aims to conduct a randomized controlled trial in comparing cognitive behavioral insomnia prevention program with the active control group in youths who are at risk of insomnia and to explore the effect of prevention program in preventing the incidence of insomnia problems.

Eligibility criteria:
inclusion criteria: * youth aged between 15-24 years (as defined by who); * written informed consent of participation into the study is given by youth and his/her parents if under 18 years old; in addition, individual assent will also be obtained for subjects under age 18 years old; * have subclinical insomnia symptoms (at least once a month but less than 3 times/week in the past one month); * at least one of the biological parents with current or lifetime history of insomnia disorder as defined by dsm-v diagnostic criteria. exclusion criteria: * a current or past history of neuropsychiatric disorder(s); * a prominent medical condition or taking medication with potential side effects that may influence sleep quantity and quality; * having a diagnosed sleep disorder that may potentially contribute to the disruption of sleep quantity and quality as ascertained by both structured diagnostic interview for sleep patterns and disorders (disp) such as insomnia, delayed sleep phase and narcolepsy, restless leg syndrome; * having a clinically significant suicidality (presence of suicidal ideation with a plan or an attempt); * currently receiving any structured psychotherapy; * with hearing or speech deficit; * trans-meridian flight in the past 3 months and during the study.

Keywords: insomnia prevention at-risk youth cognitive behavioral approach active control group
covid-19 nasal swab trial

Conditions: Covid19

Summary: the purpose of this trial is to compare 2 types of nasonasopharyngeal swabs (a new design to a conventional nylon-flocked nasopharyngeal swab) for effectiveness.

compare the precision adm "canswab" nasopharyngeal swab to a conventional nylon-flocked nasopharyngeal swab on the basis of: 1. the amount of sars-cov2 virus (covid-19) collected by swabs, measured in ct (thermal cycles) 2. clinical concordance rate 3. patient comfort during nasopharyngeal sampling procedure

Eligibility criteria:
inclusion criteria: * 18 years and older * ability to provide informed consent * covid-19 positive cohort only: a previous, positive covid-19 test in the last 5 days and patient remains symptomatic exclusion criteria: * malformation of the base of the known skull * active nosebleed before the start of the sample
clinical performance of composites in patients with amelogenesis imperfecta

Conditions: Amelogenesis Imperfecta; Dental Caries; Dental Composite

Summary: in ai patients, adhesion still remains the first option in order to achieve an early, minimally invasive intervention, and the altered enamel still represents an acceptable substrate for bonding in some ai variants. many cases have revealed that the direct composite restorations provide satisfactory esthetic and functionality in restoring ai-affected teeth. the objective of this study was to evaluate the clinical performance of composite restorations in posterior teeth in patients afflicted with amelogenesis imperfecta using nanohybrid and nanofill composite materials


Eligibility criteria:
inclusion criteria: * the patient had to require treatment due to carious lesions in one or more surface of molars and premolars, * ai diagnosis had to be made, which had to be verified clinically, and also confirmed by anamnestic family history, or clinical examination concerning witkop's classification exclusion criteria: * patients with developmental enamel defects of other origins such as fluorosis, molar incisor hypomineralization; * ai was associated with other oral developmental or systemic disorders, and dental abnormalities such as open-bite, deep-bite, and cross-bite; * patients who were unable to provide their informed consent.