Kornimate/medical-research-clean huggingface dataset:
multimodal sexual dysfunction intervention in hct

Conditions: Hematopoietic Stem Cell Transplantation; Hematologic Diseases; Sexual Dysfunction

Summary: this research study is evaluating the impact of an intervention to improve sexual function in stem cell transplant survivors on participants' sexual function, quality of life, and mood. it is expected that about 120 people who have undergone a stem cell transplant will take part in this research study.

frequently survivors of stem cell transplantation report significant problems with their sexual function that impacts their quality of life, mood, and their intimacy and relationship with their partners. these issues can be very distressing to patients and their loved ones. the investigators want to know if the introduction of an intervention focused on improving sexual function may improve a participant's overall care and quality of life. the main purpose of this study is to compare two types of care - the study intervention versus enhanced standard care which includes receiving an educational handout about sexual dysfunction. the main goal is to assess if the intervention will improve participant's sexual function, quality of life, and mood. the intervention includes a comprehensive assessment by a transplant clinician (a transplant physician or nurse practitioner) who is trained in sexual dysfunction assessment to explore the reasons for sexual dysfunction and focus on ways to improve symptoms. -- if the transplant clinician feels additional help is needed by a sexual health expert, the participant will be referred to the sexual health clinic. in the sexual health clinic, the participant will be evaluated by an expert physician who will also focus on strategies to improve sexual function. the study will use a series of questionnaires to measure sexual function, quality of life, physical symptoms, and mood. study questionnaires will be completed in the clinic or remotely with assistance provided as needed. .

Eligibility criteria:
inclusion criteria: * adult patients (≥ 18 years) with hematologic malignancy who underwent autologous or allogeneic hct ≥ three months prior to study enrollment. * positive screen for sexual dysfunction that is causing distress based on the national comprehensive cancer network (nccn) survivorship guidelines * ability to read and respond to questions in english or to complete questionnaires with assistance from an interpreter. exclusion criteria: * patients with relapsed disease requiring treatment * patients with a planned second transplant * patients \> 5 years from their hct * patients with psychiatric or cognitive conditions which the treating clinicians believes prohibits compliance with study procedures.

Keywords: hematopoietic stem cell transplantation hematologic diseases sexual dysfunction
effects of proprioceptive neuromuscular training on sensory and motor function in guillain barre syndrome

Conditions: Guillain-Barre Syndrome

Summary: this study aims to determine the effects of proprioceptive neuromuscular training on sensory versus motor function in patients presenting with guillain barre syndrome.

this study will be a randomized controlled trial and will be conducted to determine the effects of proprioceptive neuro-muscular training on sensory and motor function of lower limb,in this study data will be collected from multiple hospitals of lahore via berg balance scale, timed up and go test one leg stance test before and after intervention. non- probability convenient sampling technique will be used to enroll 26 patients in total. the patients will be randomly allocated into two groups through lottery method, to either the proprioceptive training group or control group.both groups will be assessed for proprioception via lower extremity position test as a baseline. proprioception training programme will be implemented in experimental group and will be carried out for eight weeks, with three (60-minute) sessions per week. it will start with 10 minutes of warm-up. this will be followed by 30 minutes of proprioceptive exercises targeting lower extremities. proprioceptive exercises will be divided into three components, standing on foam with eyes open and eyes closed and passing any object from one subject to the other for 10 minutes, throwing and catching a ball will be performed while standing on foam for additional 10 minutes, throwing and catching a ball, will be performed on trampoline to further challenge the balance system. after each set of 10-minute exercise, the subjects will be given two-minute resting periods. in the end, 10 minutes will be given for cool down exercises to bring the heart rate back to resting level. all participants in both groups will be evaluated before and after the treatment programs. data will be analyzed by using statistical package of social sciences version 26.

Eligibility criteria:
inclusion criteria: 1. diagnosed with guillain barre syndrome already taking treatments 2. inflammatory demyelinating guillain barre syndrome patients 3. acute motor sensory axonal neuropathy 4. guillain barre syndrome patients in the subacute phase 5. guillain barre syndrome patients with impaired proprioception 6. patients with glasgow coma scale above 12 exclusion criteria: 1. other guillain barre syndrome types 2. spinal cord injury 3. traumatic neuritis 4. not fulfilling above criteria of age

Keywords: guillain barre syndrome proprioceptive neuromuscular training balance motor function sensory function
a study for small cell lung cancer (sclc) in extensive disease stage

Conditions: Small Cell Lung Cancer

Summary: comparison of two combination chemotherapies in the treatment of patients with slcl

comparison of two combination chemotherapies in the treatment of patients with slcl the combination chemotherapies for this study are carboplatin plus irinotecan versus carboplatin plus etoposide.

Eligibility criteria:
inclusion criteria: * cytological or histological proven sclc stage i or ii at 1st diagnosis * no prior chemotherapy * measurable tumor disease * karnofsky performance 70 exclusion criteria: * second malignancy ( except basal cell carcinoma, ca in situ cervix uteri) * nyha iii * chronic diarrhea, obstructive bowel syndrome

Keywords: sclc
karate or kung fu?

Conditions: Childhood ALL

Summary: sedentary lifestyle in asian children together with aversive parenting style may compromise their physical and psychological health. the aim of the proposed stratified, randomized controlled study are to explore the beneficial effects of japanese martial art (karate) and chinese martial art (ving tsun kung fu) training on improving the psychophysical health in this population. over fifty-two asian children (age = 6-12 years) will be recruited from schools in hong kong and then randomly assigned to either a karate group or a ving tsun group. children in both groups will receive the respective physical and spiritual martial art training for 3 months (3 times/week, one hour each). outcomes will be evaluated at baseline and after the intervention by a blinded assessor. primary outcomes include muscle power of the arms and legs as measured by a medicine ball throw test and a standing long jump test, respectively. secondary outcomes include flexibility as quantified by a sit-and-reach test, aggression as measured by the reactive-proactive aggression questionnaire, and attention as measured by the child behavioral checklist-youth self-report. both karate and ving tsun kung fu training programs are predicted to improve physical health of asian children. it is expected that these training programs can be incorporated into the physical education classes or extracurricular activities in schools or in the community to improve project sustainability.


Eligibility criteria:
inclusion criteria: * 6-12 years old * asian ethnicity and reside in hong kong exclusion criteria: * any physical or psychological disorders that may affect test results * previous experience in martial arts * participate in regular sports training
postpartum wellness

Conditions: Postpartum Depression

Summary: the purpose of this study is to test whether a web-based (ehealth) exercise intervention for new moms at increased risk for postpartum depression increases physical activity and decreases postpartum depression symptoms.

postpartum depression is a debilitating and costly condition that is associated with significant health consequences for mothers and children. counseling for prevention of postpartum depression is currently recommended in women at high risk of postpartum depression; however, there is a shortage of mental health care providers. there is a need for effective interventions to prevent postpartum depression that can be easily integrated into health care systems, yet do not involve intense health care system resources. ehealth interventions are promising in this regard. strong evidence suggests physical activity can reduce depression risk. this study will assess the effectiveness of an ehealth exercise intervention tailored to postpartum mothers for increasing physical activity levels and improving depressive symptoms in women at increased risk of postpartum depression. this intervention addresses several identified barriers to physical activity in postpartum women. the study will randomize 200 women to receive an ehealth exercise intervention for postpartum women or usual postpartum care. device-based physical activity and depressive symptoms will be measured at 3 and 6 months after randomization.

Eligibility criteria:
inclusion criteria: * kpnc member between 2 and 6 months postpartum * current phq-8 score between 10-20 and no current depression diagnosis * delivered baby in kpnc * english-speaking * own a smartphone, computer, or tv with internet access * free of a heart condition and a physician recommending medically supervised physical activity * body mass index (bmi) between 18.5 and 40 (kg/m2) * a baby weighing between 11-22 lbs exclusion criteria: * engaged in regular, moderate or vigorous physical activity \>90 minutes or more per week * pregnant or planning to become pregnant in the ensuing three months * a baby with chronic illness/disorder(s) that prevent participant from holding or lifting him/her * chest pain during physical activity, or has had chest pain within the prior month * taking medication for hypertension or a heart condition * tendency to fall due to syncope or dizziness * orthopedic problems that might be aggravated by physical activity * has exercise-induced asthma

Keywords: exercise postpartum depression physical activity ehealth intervention
motivating smokers--reduce child environmental tobacco smoke exposure

Conditions: Lung Diseases

Summary: to evaluate the efficacy of a motivational intervention designed to reduce children's exposure to environmental tobacco smoke in the household and to increase parental motivation towards smoking cessation.

background: the study tested the hypothesis that motivational intervention would yield greater reduction in smoking-related indices, compared to a usual care comparison condition. the study also predicted that the motivational intervention would differentially impact on cognitive and behavioral mediating mechanisms that accelerate behavior change and maintenance. finally, the study tested the hypothesis that the motivational intervention would yield greater reduction in household exposure to environmental tobacco smoke (ets), and therefore would also result in a significantly reduced number of children's respiratory illnesses. design narrative: this study utilized a community health center that served a low ses population in rhode island. the population was approximately 40 percent hispanic and 45 percent caucasian. subjects were randomized to two intervention conditions:(1) a motivational intervention, that utilized self-help, telephone counselor calls, and motivational interviewing to provide feedback about children's health status and household concentrations of nicotine; (2) usual care, which included provision of self-help materials only. a repeated measures design was used (baseline, 3- and 6-month follow-ups). outcome measures included household nicotine concentrations, movement through the stages of readiness to change, smoking cessation attempts, point-prevalence abstinence rates, and children's health status. several important public health priorities for research in lung health and prevention were targeted in this study, including: (1) reduction of ets exposure among children from low income families, a group that has had a particularly high prevalence of chronic ets exposure;. (2) development and evaluation of an intervention that was specifically tailored to match the characteristics of smokers who were low in motivation to quit smoking, a group that constituted 80 percent of the lower ses smoking population, yet that had been largely ignored in smoking research; (3) smoking intervention with an underserved, low-income and ethnic population that had poor access to standard approaches to smoking cessation and a particularly high smoking prevalence (household smoking prevalence = 60 percent); and (4) assessment of the impact of reductions in household ets exposure on the respiratory health of children in the context of a longitudinal study. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
effects of low frequency magnet therapy on spasticity in patients with cerebral palsy

Conditions: Spastic Cerebral Palsy

Summary: background: spasticity is a major challenge in patients with cerebral palsy (cp). it may cause unwanted complications and may affect the patient's quality of life. currently there is no satisfactory long lasting control of spasticity. many lines of evidence indicate that magnet therapy may be a useful intervention in the management of spasticity. several studies showed that magnet may inhibit neuronal firing in the human nervous system; however, its effects weren't studied on spasticity. objectives: the goal of the present study was to determine the short-and long-term effects of pulsed low frequency magnetic field therapy on spasticity in patient with cp. methods: 48 patients with cp, who have measureable level of spasticity, were selected. the sample was divided randomly into active magnet group (received magnet therapy, 32 subjects) and placebo group (16 subjects). at the end of the 4th week the magnet group was divided into two sub-groups: 1st sub-group received magnet therapy for another 4 weeks while the other received the placebo. measurements was taken at baseline, 4th, 8th and 12th weeks. modified ashworth scale was used to measure spasticity, foot pressure platform system was used to measure the contact area and the maximum force of the feet, gross motor function measure (gmfm) was used to measure the functional level of the patients. the cerebral palsy quality of life (cp-qol) questionnaire was used to measure the patients' various dimensions of quality of life.


Eligibility criteria:
inclusion criteria: * a confirmed diagnosis of diplegic or quadriplegic cp of both genders, * able to stand without assistance. * age from 4-16 years * measureable spasticity (1 or more according to the modified ashworth scale). exclusion criteria: * have recent organ transplants. * have heart pace maker. * have cardiac arrhythmia, tachy cardiac conditions or large aneurysm. * have heavy psychosis. * underwent any neuromuscular blockers of spasticity. * underwent any surgery of tendon lengthening before or during the study. * have epileptic episodes.
open-label ca-008 (vocacapsaicin) in bunionectomy

Conditions: Pain

Summary: a phase 2, open-label study of ca-008 to evaluate post-surgical pain control with ca-008.

this is a phase 2, single-center, open-label study evaluating a single dose of ca-008 4.2 mg administered with different standard-of-care anesthetic regimens during an elective unilateral transpositional first metatarsal osteotomy for the correction of hallux valgus deformity (bunionectomy).

Eligibility criteria:
inclusion criteria: 1. healthy adult aged 18 - 65 years old 2. american society of anesthesiology (asa) physical class 1, 2 or 3 3. planning elective bunionectomy repair 4. for both males and females: using an acceptable method of birth control 5. if a female: not pregnant or breastfeeding 6. have a body mass index ≤ 36 kg/m2 exclusion criteria: 1. have another painful condition, other than bunion-related pain, that may require pain treatment during the study period 2. have active skin disease or another abnormality at the anticipated site of surgery that could interfere with the planned surgery. 3. have a known allergy to study medications. 4. have a history of significant medical, neuropsychiatric or other condition, including a clinically significant abnormal clinical laboratory test values 5. have positive results on the alcohol test (breath or saliva) or urine drug screen.
the effectiveness of the microfracture technique in the meniscal healing

Conditions: Microfractures; Meniscus Tear

Summary: meniscus injuries are a very common cause of knee pain. the meniscus is a semilunar fibrocartilage structure found on the medial and lateral sides of the knee. the meniscus serves to absorb impact and protect the articular cartilage during weight-bearing activities, joint stability, proprioception, and nutrition. this has a significant effect on knee biomechanics. after the menisci are injured, the biomechanics of the knee change so that degenerative changes occur more frequently in the tibiofemoral compartment. improvement of tibiofemoral arthrosis after meniscectomy surgery has been demonstrated in several long-term clinical studies. with increasing awareness of the importance of the meniscus in knee biomechanics, various meniscus repair techniques have been developed. in addition, several adjuvants for healing have been proposed to enhance meniscus healing. however, a study showed the meniscal repair failure rate increased from 22% to 24% at 5 years. study found the healing rate of meniscus repair, which was accompanied by acl repair, had a greater healing rate, 93% vs. 50%. hemarthrosis that occurs after bony tunneling during acl reconstruction provides a fibrin clot and an environment rich in factors that promote healing of the newly repaired meniscus. the fibrin clot provides the structural foundation for meniscus healing. transmission factors, such as fibronectin and growth factors, are also present. microfracture is a common procedure used for the treatment of damage to the articular cartilage in the knee. this procedure is used to stimulate the production of fibrocartilage in areas of injured cartilage. microfractures are performed by creating 1 or more small channels (1 to 3 mm in size) that pierce the subchondral bone and release bone-forming components into the joint. microfractures serve to promote the formation of fibrocartilage over damaged cartilage. research in 2016 used an animal model (capra hircus) to investigate the effectiveness of the microfracture technique on meniscus tear healing rates. they found significant healing in meniscal repair accompanied by microfracture technique (65% vs 12%). however there is still not enough research regarding the efficacy of microfracture in meniscal healing, especially among indonesian. therefore, the investigators aim to investigate its efficacy.


Eligibility criteria:
inclusion criteria 1. patients with meniscus tears 2. the patient underwent meniscus repair surgery using arthroscopy. 3. have an mri examination before and after surgery within 6 months post-surgery. b. exclusion criteria 1. patients with meniscus tears in the white-white area 2. the patient underwent meniscus repair surgery without using arthroscopy 3. the patient did not perform an mri examination before after surgery within 6 months post-surgery.

Keywords: meniscus tear microfracture
long term follow-up of the "stryker dacron and trevira ligament" for anterior cruciate ligament (acl) repair

Conditions: ACL Rupture; Replacement

Summary: about 20 years ago synthetic ligaments were used in orthopaedics / traumatology for the repairing and replacement of injuries of the anterior cruciate ligament. after less than 10 years it appeared that a relatively important number of patients showed complications on the basis of synovitis. the situation of another group of patients on the other hand evolved favourably without complications. the study to focuses on this group of patients and attempts to determine how the replacement without problems ab initio, evolved in the time. it concerns a group of 57 patients who received an implantation in the uz ghent between november 85 and october 87 with the stryker dacron ligament and a group of 33 patients who received the trevira ligament in the asz aalst. the clinical result will be stipulated by means of standardized questionnaires and a clinical examination. the radiological result will be determined by the degree of integrity of the ligament that was implanted at the time. in this way the study could give an idea about the degree in which the technical success of the intervention correlates with the clinical success 20 years later.


Eligibility criteria:
inclusion criteria: * patients that received a stryker dacron or trevira ligament to replace there acl. * max age: 75 * min age: 49 * minimum follow up: 22 years

Keywords: acl