Kornimate/medical-research-clean huggingface dataset:
physical activity and cardiorespiratory fitness in adolescents with autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: the purpose of this study is to increase knowledge and insights with regard to physical activity behavior in adolescents with autism spectrum disorder.

low levels of physical activity (pa) in adolescents with autism spectrum disorder (asd) increase the risk for both physical and mental health problems during adolescence and subsequent adulthood. to enable the identification of adolescents with asd at risk for developing an inactive lifestyle and to inform the future design of high-quality, evidence-based and asd-specific pa interventions and programs, several gaps of the current literature need to be addressed. 1. to date, no pa and cardiorespiratory fitness (crf) tests have been validated in adolescents with asd, causing an inability to accurately assess and interpret these two important health markers. 2. there is a lack of knowledge regarding pa correlates in this population, resulting in difficulties to identify adolescents with asd at risk of developing an inactive lifestyle. 3. it is still unknown why adolescents with asd are predominantly inactive and qualitative research of the perspectives of adolescents with asd towards pa participation in order to understand their pa behavior is scant. therefore, the aims of this project with regard to adolescents with asd are: 1. to examine the concurrent validity of two self-report pa instruments and the concurrent validity and test-retest reliability of a submaximal crf test. 2. to determine potential complex and multiple (interactions between) correlates of pa, using a comprehensive assessment protocol. 3. to explore the perspectives of adolescents with asd concerning the barriers and facilitators of pa participation.

Eligibility criteria:
inclusion criteria: * written informed consent/assent * asd diagnosis according to the dsm-iv/5 * proficient knowledge of dutch exclusion criteria: * a physical disability hampering the administration of the standardized tests (e.g. unable to sit on a bicycle/perform a motor skill test in standing position) * participants with an intellectual disability (defined as an intelligence quotient \< 70) * participants with severe medical problems (e.g. severe metabolic disorders, oncological disease, diabetes), because of safety reasons * wave 1 participants only: the use of antipsychotics, because of safety reasons in the context of performing a maximal exercise test * participation in another clinical trial * in case of pregnancy

Keywords: physical activity adolescents cardiorespiratory fitness
safety and efficacy of medications covid-19

Conditions: Severe Covid-19

Summary: we performed a quasi-experimental open-label pragmatic study alternating standard of care (soc) and oral bedtime melatonin (obm) at different high doses over 4 consecutive time periods enrolling all consecutive rt-pcr sars-cov-2 severe covid-19 admissions.

the 4 successive study time periods spanned from march 2020 to april 2021 and included: 1) standard of care (soc) (c1), 2) soc + oral bedtime melatonin (obm) (t1), 3) soc (c2), and 4) soc + obm (t2). during t1, 3 consecutive subgroups received 50 mg, 100 mg and 200 mg obm. during t2, 100 mg obm was given. melatonin was administered from icu admission to hospital discharge or death. the main objectives were occurrence of predefined severe adverse events (saes), sequential organ failure assessment (sofa) scores and day-30 (d30) and 90 (d90) mortality. study subjects were followed for modified rankin scale (mrs) at 30 days after the last obm dose or hospital discharge.

Eligibility criteria:
inclusion criteria: * positive rt-pcr for sars-cov-2 exclusion criteria: * anticipated death within 48 hours or paliative care

Keywords: covid-19 adverse events organ dysfunction mortality
progressive strength training in spinal muscular atrophy

Conditions: Muscular Atrophy, Spinal

Summary: the proposed feasibility study is necessary to test if children and young adults will participate in and adhere to a 12-week, home-based, supervised progressive strength training exercise program and to obtain preliminary data that will subsequently allow us to determine the safety and impact of strength training in spinal muscular atrophy. our pilot study will address 3 aims: (1) ascertain the feasibility of, and potential barriers to, participation in and adherence to a 12-week home-based, supervised, progressive strength training exercise program in children and young adults aged 5-21 years with sma types ii and iii; (2) determine the safety and tolerability of progressive strength training in a pilot study sample of children and young adults with sma types ii and iii; and (3) determine candidate outcome measures.


Eligibility criteria:
inclusion criteria: * age 5-21 years * diagnosis of sma type ii or iii * at least antigravity strength in elbow flexors * ability to follow commands and stay on task * place of residence within a 60-minute or 60-mile drive of the university of utah exclusion criteria: * planned surgery or out-of-town trips during the proposed intervention period * inability to travel to study center for testing * neurological diagnosis other than sma

Keywords: spinal muscular atrophy neuromuscular disorder progressive strength training children
impact of a training program on the body composition of overweight and obese young adults : concentric versus eccentric exercise

Conditions: Adults; BMI>35

Summary: nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle wich permits eccentric (ecc) lower limbs contractions at a defined power output. with this type of ergometer, o2 consumption (vo2) in ecc is three fold lower than in concentric (con) for the same power output. consequently, ecc program could be used in chronic disorders with limited capacities, such as obesity. the investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. this effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ecc training (versus con training). this study aims to compare the modification of fat mass after an ecc program versus a con program at the same vo2. the secondary goal is to assess the physiological mechanisms involved in the modification of body composition

thirty adults will be randomized into 2 groups: con or exc. the patients of ecc group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. the training program will last 12 weeks for the two groups. before and after, each subjects will participate to the following measurements: total and segmental body composition (dxa), aerobic capacities (maximal incremental exercise test, vo2max), muscular lower limbs strength (isometric end isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

Eligibility criteria:
inclusion criteria: * - adults * obese (bmi\>35) * inactive (\<10 mets/h/week) * no other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no contraindication to physical activity exclusion criteria: * (bmi\<35)

Keywords: obesity eccentric exercise body composition training program
correlation of clinical and laboratory findings and diuretic efficacy in patients with edematous states in the emergency department

Conditions: Edema

Summary: the aim of the study is the characterization of parameters from medical history, physical examination and diagnostics, which correlate with and could be used to predict diuretic efficacy.

this prospective observational study is conducted to identify and further isolate possible predictors for the efficacy of diuretics and to identify potential new predictors. the study also observes if specific diuretic regimes (e.g. combination of loop diuretics and distal effective diuretics for sequential nephron blockade) have a greater diuretic effect. this is not yet proved. the data of the study shall to help to determine criteria, allowing to choose an effective diuretic regime in different patient cohorts already at the beginning of therapy and to identify patients at high risk.

Eligibility criteria:
inclusion criteria: * age over 18 years. * edema (peripheral and/or pulmonal) of cardiac or renal genesis. exclusion criteria: * persons who are in a dependency/employment relationship with the investigators. * accommodation in an institution by judicial or administrative order. * patients in need of ascites puncture and/or thoracentesis on admission day.

Keywords: edema
anterior prolift versus posterior prolift for pelvic floor prolapse

Conditions: Pelvic Floor Prolapse

Summary: women who had surgery for pelvic floor prolapse underwent surgery by anterior prolift or posterior prolift at least a year after the surgery. the data from the charts and from telephone conversations with the patients will be entered to a database. physical examination data will also be incorporated.


Eligibility criteria:
inclusion criteria: * women who underwent surgery by anterior prolift or posterior prolift for pelvic floor prolapse exclusion criteria: * women who did not have surgery by prolift for pelvic floor prolapse
mhealth messages to sustain recent weight loss - phase 2

Conditions: Weight Loss

Summary: to assess the feasibility to translate an automated weight loss message intervention to a weight loss clinic population. aim 1: to assess feasibility of translating the intervention in a clinic for patients who recently completed a structured weight loss program. aim 2: to assess the ability to capture a trajectory of self-reported weight over 6 months through an automated intervention.

the investigators will recruit 100 participants who are clients at the duke diet and fitness center. at baseline the investigators will collect demographic information such as, their age, weight, education. when participants complete their respective program at the dfc they will receive a daily weight loss sustaining text message at 8:00 a.m. for 60 days. participants will also receive weekly messages for 6 months asking them to self-report their weight. thereafter, they will receive an automated message monthly for 18 months asking them to self-report their weight.

Eligibility criteria:
inclusion criteria: * a client of duke diet and fitness center (dfc) * are able to speak and read english * should complete a diet and fitness program at the dfc. * client should own a mobile smart phone to personally receive text messages. * client should have access to a web-based survey to self-report their weight. exclusion criteria: * no exclusions

Keywords: mobile technology diet and fitness
3 year follow up on ano5 patients

Conditions: Neuromuscular Diseases; Limb Girdle Muscular Dystrophy

Summary: the aim of the study is to investigate progression in muscle affection in patients with pathogenic variants in the anoctamin 5 gene to: 1. investigate possible progression of disease over time 2. investigate good and reliable outcome measures

muscles of patients with pathogenic variants in the anoctamin 5 gene will over time be infiltrated with fat. this is especially visible on mri and can be seen even before any symptoms appear. mri is thus used increasingly to investigate muscle affection in neuromuscular disorders. together with functional measurements it is possible to describe how patients are affected clinically and subclinically. there are still many things that need covering - rate of progression is undertermined and good outcome measures are still needed for future clinical trials. muscles of the whole body in patients with neuromuscular disorders will be investigated 3 times through a 3 year follow-up study. the aim of the study is to investigate progression in muscle affection in patients with pathogenic variants in the anoctamin 5 gene to: 1. investigate possible progression of disease over time 2. investigate good and reliable outcome measures

Eligibility criteria:
inclusion criteria: * pathogenic variant in the anoctamin 5 gene * age more than 18 years exclusion criteria: none

Keywords: mri neuromuscular disorder outcome measure progression
regulating blood pressure during recovery from intracerebral hemorrhage and ischemic stroke

Conditions: Intracerebral Hemorrhage; Ischemic Stroke; Spironolactone

Summary: the purpose of this research study is to determine whether blood pressure treatment regimens with spironolactone are better than blood pressure treatment regimens without spironolactone at lowering blood pressure in stroke survivors.

this is a pragmatic, randomized, open-label, blinded-endpoint trial comparing spironolactone-containing antihypertensive regimens versus standard antihypertensive regimens based on the 2017 aha/acc guidelines in stroke survivors. this study will randomize a total of 200 patients, 100 white and 100 non-white patients, at least three weeks after last known normal or symptom discovery/onset of their stroke to an antihypertensive regimen with spironolactone once daily or standard bp control based on the 2017 aha/acc guidelines for 1 year. participants will undergo baseline testing for neurohormonal levels and will be followed for 12 months with regular assessment of home bp readings. the primary outcome of home systolic bp will be measured at 3 months.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years 2. symptomatic ich confirmed by head ct or brain mri during hospitalization or ischemic stroke patients. ischemic stroke will be defined by focal signs/symptoms of any duration associated with evidence of acute arterial infarction on neuroimaging or clinical evidence of cerebral focal arterial ischemic injury with symptoms persisting ≥ 24 hours. 3. written, informed consent by patient or surrogate 4. ability to comply with all study procedures and available for the duration of the study exclusion criteria: 1. secondary ich due to trauma, vascular malformation, or tumor 2. life expectancy \< 1 year 3. egfr \<45 4. serum potassium greater than or equal to the upper limit of normal of the lab on the two most recent consecutive potassium levels prior to enrollment 5. known hypersensitivity to spironolactone 6. upper arm greater than 17 inches in circumference 7. pregnancy, planned pregnancy, or breastfeeding 8. contraindication to discontinuing mineralocorticoid antagonist therapy for 3-12 months per the investigator's discretion (e.g., refractory proteinuria) 9. systolic bp \>200 mmhg or diastolic bp \>110 mmhg at the time of randomization 10. systolic bp \<120 mmhg at the time of randomization 11. any condition which, in the judgement of the investigator, increases the risk to the patient 12. history of addison's disease
community surveillance of congestive heart failure

Conditions: Cardiovascular Diseases; Heart Failure, Congestive; Heart Diseases; Heart Failure

Summary: to conduct a surveillance study of congestive heart failure (chf).

design narrative: systematic surveillance was conducted of chf among residents, 35-84 years old, of the minneapolis-st.paul metropolitan area (population 2.45 million, 1995 estimate) in two complementary domains: 1) hospitalization for chf in two calendar years, five years apart (1995 and the year 2000); and 2) newly diagnosed chf over a 9-year period (1993-2001) among members of a large health maintenance organization (hmo). the magnitude and characteristics of hospitalized chf were assessed in all 21 acute care hospitals of the metropolitan area. one-third of all discharges with icd-9 chf codes were sampled randomly (n about 5,000 per surveillance year), abstracted by trained nurses, and classified according to clinical criteria and the results of diagnostic tests. newly diagnosed chf was distinguished from recurrent episodes of decompensated chf by thorough review of the hospital record. a complementary perspective on chf, including the outpatient setting, was provided by a systematic study of members of healthpartners, one of the largest hmos in minneapolis-st. paul. using the healthpartners database, all newly diagnosed chf cases between january 1, 1993 and december 31, 2001 (n about 1,900) were identified and the diagnosis validated. beginning in january 1, 1999, newly diagnosed chf cases were identified on an ongoing basis (n about 600), surveyed by mail, and followed for one-year from the original diagnosis. surveillance of the healthpartners population supplemented hospital surveillance and contributed data on incidence, prevalence, treatment, use of resources, and patient outcomes. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
bnp guided care in addition to multidisciplinary care

Conditions: Decompensated Heart Failure

Summary: hf is associated with repeated hospitalisations and poor prognosis.the aim of this study is to investigate whether bnp-guided care (bgc) in addition to multidisciplinary management(mm) improves outcome compared to hnc alone or usual care (uc) for decompensated hf patients after discharge. patients hospitalised with cardiac decompensation in 9 viennese hospitals are randomised to bgc, mm alone, or uc. mm includes 2 consultations of a heart failure (hf) specialist 10 days and 2 months after discharge for recommending medical optimisation and care by a specialised hf nurse including 4 home visits and telephone contact. in addition, bgc includes intensified increase of medical treatment during repeated follow-up visits in a hf clinic in patients with an nt-bnp level above 2200pg/ml at discharge.


Eligibility criteria:
inclusion criteria: 1. clinical signs and symptoms of cardiac decompensation during the present hospitalisation 2. nyha class iii or iv at time of admission 3. cardiothoracic ratio \> 0.5, and/or left ventricular ejection fraction \<40% documented by echocardiography exclusion criteria: -
out-of-hospital cardiac arrest epidemiology and outcomes in kaunas 2016-2021

Conditions: Out-Of-Hospital Cardiac Arrest

Summary: out-of-hospital cardiac arrest rate is common problem, because of high mortality rate. it is not clear incidence rate, epidemiology and outcomes in lithuania and kaunas city included.

this data reported according to utstein guidelines could be compared with other countries from the region although not much data is available, but it will be a baseline for future references about processes in patient management, demographics, incidence rate and ohca outcomes.

Eligibility criteria:
inclusion criteria: * ohca patients of all ages more than 18 years-old with resuscitation commenced or continued by ems personnel were included. exclusion criteria: * obviously dead patients, were excluded
comparative effects of spencer and reverse distraction technique in patients with adhesive capsulitis

Conditions: Adhesive Capsulitis

Summary: to compare the effects of spencer and reverse distraction technique in patients with adhesive capsulitis

adhesive capsulitis, also known as frozen shoulder, is an inflammatory condition characterized by shoulder stiffness, pain, and significant loss of passive range of motion. adhesive capsulitis has a prevalence of approximately 2% to 5% in the general population, with a mean onset of age of 55. a randomized clinical trial will be conducted at ibne sina hospital, multan . non probability convenience sampling technique will be applied on 50 patients who will be allocated through computerized randomization into group a \& group b to collect data. group a will be given spencer technique and group b will be given reverse distraction technique along with baselines. the study will be completed within the time duration of ten months. primary outcome measures of the research will be pain, range of motion, function, muscle strength, disability and quality of life will be measured pre and post intervention. the whole treatment protocols will be given for four weeks. data will be analyzed using spss software version 25. after assessing normality of data by shapiro-wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.

Eligibility criteria:
inclusion criteria: * age group 40-60 years * male and female * positive capsular pattern (er more limited than abd which is more limited than ir) * limitation in shoulder rom ; flexion \<180 , abduction \<180 , external rotation \<50 * patients of stage 2 and 3 of adhesive capsulitis exclusion criteria: * history of surgery of the affected shoulder * fractures in around the shoulder * neurological disorders leading to altered muscle activity * systemic arthritic conditions (ra, osteoporosis) * disorders of the cervical spine
geniculate artery embolization for treatment of persistent knee pain post total knee arthroplasty

Conditions: Knee Pain

Summary: single-arm, single-center, no sham or placebo, prospective pilot trial designed to evaluate the safety and efficacy of transcatheter arterial embolization in patients with persistent knee pain resistant to conservative management for at least 9 months after total knee arthroplasty (tka). eligible participants will receive geniculate artery embolization (gae) using embozene™ color-advanced microspheres. patients will be followed up for a total of 24 months after gae.


Eligibility criteria:
inclusion criteria: * knee pain resistant to conservative treatment for at least 9 months post tka performed for knee oa, and * moderate to severe knee pain: pain vas ≥40 mm, and * willing, able, and mentally competent to provide informed consent and complete study questionnaires in english. the study questionnaires are validated in english. exclusion criteria: * active systemic or local knee infection or; * active malignancy or; * life expectancy less than 6 months or; * prior ipsilateral knee arthroscopic surgery or repeat tka (within 9 months of screening) or; * ipsilateral knee intra-articular injection in the last 3 months or; * rheumatoid arthritis, spondyloarthropathies, crystal disease, gout, pseudogout, or lupus or; * pregnant during the study period or; * renal dysfunction as defined by serum creatinine \>1.6 dl/mg or egfr \<60 on blood tests obtained within 30 days of procedure or; * body weight greater than 200 kg or; * known history of severe contrast allergy to iodinated contrast resulting in anaphylaxis or; * known significant arterial atherosclerosis that would limit selective angiography and/or lower extremity symptoms thought to be secondary to arterial vascular disease (eg claudication, ischemic rest pain) or; * known avascular necrosis in the target knee or; * complications of tka such as suspected or confirmed early loosening, ligamentous instability, reflex sympathetic dystrophy, polyethylene wear with or without particle disease (osteolysis), and large effusions (with or without hemarthrosis) or; * patient is enrolled in a different trial for treatment of knee pain post total knee arthroplasty (ipsilateral knee)