Kornimate/medical-research-clean huggingface dataset:
socket shield technique versus early implant placement with contour augmentation

Conditions: Bone Loss; Bone Resorption

Summary: comparing socket shield technique with early implant placement with contour augmentation in preserving the bone contour

comparing immediate implant placement with socket shield technique and final crown after 3 months with extraction and after 4 to 8 weeks implant placement with contour bone augmentation then after 3 to 4 months final crown delivery

Eligibility criteria:
inclusion criteria: 1. non-restorable maxillary teeth in the esthetic zone 2. intact adjacent teeth 3. adequate palatal and apical bone that allows achieving implant primary stability. 4. type i socket 5. ≥18 years 6. ≤ 60 years 7. systemically healthy patients exclusion criteria: 1. extraction sockets with acute or chronic infection or with adjacent infected teeth 2. heavy smokers \> than 10 cigarettes daily 3. cancer patients undergoing radiotherapy or chemotherapy during or within the last 6 months. 4. unmotivated patients to maintain adequate oral hygiene to follow up. 5. patients with physical disabilities that could affect follow up.
impact of air pollution on the autonomic nervous system activity and the presence of sleep apnea in older subjects

Conditions: Healthy

Summary: impact of air pollution on the autonomic nervous system activity and presence of sleep apnea in older subjects.

the relation between the air pollution and morbidity, cardiovascular mortality was increasing interest. analyses show an increase of respiratory difficulty, but also cardiac deaths in the daytime when the atmospheric pollution was increased. it was demonstrated that health effects of ambient air pollution in subjects presenting cardiac or lung difficulty were important. mechanisms show a possible relation to autonomic nervous system (ans) deactivation and mortality. particularly, the ageing and ans reach would be more predictive of cardiovascular events. thus, we suggest estimating in 60 healthy volunteers from 60 to 80 years old, the impact of the air pollution on the autonomic nervous system activity and sleep apnea consequences.

Eligibility criteria:
inclusion criteria: * reside in lyon and saint-etienne cities * security social affiliated or beneficiary * information note signed exclusion criteria: * heart rate disorders * pacemaker * tabacco addiction or second-hand smoke * morbid obesity (bmi \> 30) * insulin-dependent diabetes * chronic disease on treatment * antiarrythmic treatments

Keywords: air pollution autonomic nervous system sleep apnea heart rate variability healthy volunteers
ttt of adenomyosis

Conditions: Adenomyosis

Summary: to evaluate use of dienogest versus uterine arteries embolization in treatment of adenomyosis-associated symptoms as dysmenorrhea, heavy menstrual bleeding and bulk-related symptoms

type of the study: prospective cohort comparative study. setting: it will be done at both obstetrics \& gynecology department and radiology department, al-azhar university hospital assiut branch. time of the study: starting from january 2025 till the end of the study number of cases: 100 cases. according to sample size equation where; in: n = number of patients, = 1.96 (standard normal deviate value that divides the central 95% of z distribution from 5% in the tails), p = the reported sensitivity (67%, i.e., 0.67), l= absolute precision desired on either side (half width of the confidence interval of the confidence interval) of sensitivity (10% i.e., 0.1). inclusion criteria: * age group: 30-50 years * women with adenomyosis * with or without small fibroids * suffering from heavy menstrual bleeding, dysmenorrhea, and/or cycle- independent pain and bulk-related symptoms. exclusion criteria: * presence of a malignancy or pelvic infection. * an on-going pregnancy or a desire to conceive in the future. * absolute contraindication for angiography (renal impairment). * chronic debilitating diseases.

Eligibility criteria:
inclusion criteria:- age group: 30-50 years * women with adenomyosis * with or without small fibroids * suffering from heavy menstrual bleeding, dysmenorrhea, and/or cycle- independent pain and bulk-related symptoms. exclusion criteria: * - presence of a malignancy or pelvic infection. * an on-going pregnancy or a desire to conceive in the future. * absolute contraindication for angiography (renal impairment). * chronic debilitating diseases.
shear wave ultrasound elastography in noninvasive diagnosis of thyroid nodules

Conditions: Thyroid Nodule

Summary: shear wave ultrasound elastography is a new technique of finding the softness or hardness in tissue by applying a "push" generated by the machine. this technique will help in diagnosing malignancy in the thyroid gland without biopsy and avoiding biopsy in noncancerous nodules.

thyroid nodules are a common medical problem. with the wide use of various imaging modalities, incidentally detected thyroid nodules are becoming more common. however most of these nodules are benign with only a small proportion of 5-10% being malignant. with the increasing number of nodules detected, evaluation of these thyroid nodules presents a diagnostic challenge since the imaging modality used for evaluation at present, i.e., ultrasound (us) alone, has a low specificity of approximately 50-70%. in order to improve specificity to confidently diagnose malignancy in the thyroid nodule, a fine needle aspiration (fna) biopsy is performed. in recent years, us elastography has been shown to have high specificity of 90- 98% in various studies in differentiating between benign and malignant nodules. us elastography works on the principle of detecting the stiffness within a tissue by applying compression which can be manual compression or by generation of a remote radiation force by focused ultrasonic beams called as shear waves. shear wave ultrasound (swus) elastography is an objective method of us elastography that detects the stiffness within the nodule since the strength of the shear wave generated is known and can be controlled. swus elastography has shown promise in being able to noninvasively diagnose papillary carcinoma in previous studies involving preoperative patients. the investigators propose to perform a study to investigate the efficacy of swus elastography in diagnosing malignant thyroid nodules and noninvasively decreasing the number of fnas performed by avoiding fna in benign nodules. the investigators will enroll patients with thyroid nodules before they undergo fna biopsy or surgery. we also propose to compare routine us and swus elastography and their combined use in differentiating malignant from benign nodules. the investigators hypothesize that swus elastography can be used as a noninvasive screening tool, prior to an fna, to screen out benign and malignant nodules with high level of confidence and reduce the number of biopsies in the future.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of thyroid nodule * referred for thyroid fna or surgery exclusion criteria: * minors; age \<18 * unable to provide informed consent

Keywords: thyroid nodule thyroid neoplasm differential diagnosis elastography elasticity imaging technique sonoelastography
continuous passive motion device for children with arthrogryposis

Conditions: Arthrogryposis

Summary: the investigators are investigating a continuous passive motion device to exercise the knee of young children with arthrogryposis after they have had knee surgery.

the investigators will measure the effect of continuous passive motion (cpm) of the knee joint post-surgery on young children with arthrogryposis. the investigators have developed a motorized brace that will move the joint through a prescribed range of motion and speed while the subject is seated. the objective of this pilot study is to develop the device from subject feedback and determine the right dose and speed of cpm to provide. cpm is routinely used for adults and older children after surgery to maintain range of motion. the machines used are too large for young children therefore the investigators have developed a prototype for small sized kids that will exercise their knee joint post-surgery.

Eligibility criteria:
inclusion criteria: * children with arthrogryposis * children between 3 and 7 years of age * children who have had recent knee surgery exclusion criteria: * children older than 7 * children unable to cooperate with protocol steps
the oscillation of crystalline and intraocular lenses

Conditions: Marfan's Syndrome With Ocular Manifestations; Pseudoexfoliation Syndrome; Cataract; Phakodonesis; Ectopia Lentis

Summary: the crystalline lens of the human eye helps to sharpen vision. there can be issues with the support/stability of the lens. this could be seen with the naked eye of an external observer or with the use of a slit lamp. certain eye conditions can predispose to issues with lens stability. if patients have stability issues with their natural lens- this would be termed as "phakodonesis". however, in patients who have had prior cataract surgery with implantation of an artificial lens (iol)- this would be termed as "pseudophakodonesis". eye conditions such as pseudoexfoliation or marfan-syndrome can lead to unstable lens support- this can be detected if there are advanced stability issues. however, small instability in the eye's would not be detected with present descriptive methods. the authors have designed a high-speed camera which is able to detect stability of the lens, especially during eye movements. the high-speed camera can detect variation in the change of light reflex from the lens and calculate the amount of lens instability/oscillation. the results (in normal eyes) of this high-speed camera has already been published in a peer-review journal. it is non-contact and measures lens movement. the test lasts less than 5 minutes. further research is required to assess the amount of lens oscillation (wobbling) in different eye populations - patients with previous cataract surgery (an artificial implant is used to replace the lens) or eye conditions (such as pseudoexfoliation, marfan syndrome). the amount of lens stability has a role in the planning of further intraocular surgery - especially cataract extraction - however, at present, there is no approved quantitative measurement for this. participants will be recruited through anglia ruskin university (educational establishment), local community groups, and through southend university hospital eye clinics (nhs organisation). participants' data will remain anonymous.


Eligibility criteria:
inclusion criteria: * \>18 years old * able to read and understand the english language exclusion criteria: * significant corneal scarring * taking medications that cause miosis (pupil constriction) * patients with no light perception * patients unable to open their eyes e.g. due to significant ptosis
a safety pk/pd study of slv337 in patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to assess safety, tolerability, pharmacokinetics and pharmacodynamics of slv337 in patients with type 2 diabetes


Eligibility criteria:
inclusion criteria type 2 diabetes ,stable dose of metformin,hba1c \>= 7%, but \ 40.0 kg/m2, evidence of unstable cardiovascular diseases, nyha class i to iv, alt \> 1.5 times unl, creatinine clearance \<60 ml/min

Keywords: type 2 diabetes interventional placebo controlled pk pd safety
efficacy and safety of aliskiren 75 mg, 150 mg, and 300 mg in elderly patients with essential hypertension when given with a light meal in a 8 week placebo-controlled study

Conditions: Hypertension

Summary: this study will evaluate the efficacy and safety of aliskiren 75 mg, 150 mg, and 300 mg in elderly patients with essential hypertension when given with a light meal.


Eligibility criteria:
inclusion criteria: * male and female outpatients 65 years of age and older. * patients who are eligible and able to participate in the study, and who consent to do so after the purpose and nature of the investigation has been clearly explained to them (written informed consent). * at the randomization visit patients must have an office mssbp greater than or equal to 150 mmhg and \< 180 mmhg (msdbp \<110 mmhg) with a less than or equal to 15 mmhg difference during the last two visits of the single blind run-in period. exclusion criteria: * severe hypertension \[office msdbp ≥110 mmhg and/or mean sitting systolic blood pressure (mssbp) ≥ 180 mmhg\]. * history or evidence of a secondary form of hypertension. * known keith-wagener grade iii or iv hypertensive retinopathy. * history of hypertensive encephalopathy or cerebrovascular accident, including a history of transient ischemic cerebral attack (tia). * current diagnosis of heart failure (nyha class ii-iv). * history of myocardial infarction, coronary bypass surgery, or any percutaneous coronary intervention (pci). * current angina pectoris requiring pharmacological therapy other than nitrates. other protocol-defined inclusion/exclusion criteria applied to the study.

Keywords: hypertension ≥ 65 years aliskiren placebo light meal
the efficacy of a vr enhanced video exposure therapy for dental phobia

Conditions: Dental Phobia

Summary: evaluation of a one session vr - enhanced video exposure therapy for dental phobia. diagnosed dental phobics will be randomly assigned to one of two conditions: (1) psychoeducation + vr exposure (2) psychoeducation + video control treatment. prior to getting the therapy, participants will be evaluated with a questionnaire battery, diagnosed with a structured clinical interview and will participate in a psychophysiological symptom assessment. then, after a 2-week waiting period, participants again fill in questionnaires, and the intervention will take place. within 2-weeks after the second questionnaire assessment participants will be screened with the structured interview again and will fill in questionnaires.


Eligibility criteria:
inclusion criteria: - diagnosed specific dental phobia exclusion criteria: * schizophrenia or other psychotic illnesses * bipolar disorder * chronic headache * other neurological disorders such as epilepsy * hearing problems
shrinking target adaptive radiotherapy for locally advanced non-small cell lung cancer

Conditions: Non Small Cell Lung Cancer

Summary: this study aims to use a type of radiation (adaptive radiotherapy) to deliver curative-intent treatment to patients with non-small cell lung cancer, whose tumors would otherwise be too large for standard curative treatment. the study will use adaptive radiotherapy to achieve these goals. adaptive radiotherapy is a process whereby treatment plans are modified during the course of treatment due to patient and tumor variations (ie. weight loss or tumor shrinkage). this may allow for dose escalation, while limiting the side effects.


Eligibility criteria:
inclusion criteria: * age 18 or older * willing to provide informed consent * ecog performance status 0-2 * histologically confirmed non-small cell lung carcinoma * locally advanced stage iiia or iiib lung carcinoma according to ajcc 7th edition * expected lung v20 of 35-60%, as determined at the time of 4d-ct simulation * assessment by medical oncologist and radiation oncologist, with adequate hepatic and renal function for administration of cisplatin-based doublet chemotherapy, at the discretion of the medical oncologist exclusion criteria: * serious medical comorbidities or other contraindications to radiotherapy or chemotherapy * prior history of lung cancer within 5 years * prior thoracic radiation at any time * metastatic disease * in some select cases, patients with a solitary metastasis (i.e. brain metastasis) may receive radical chemoradiotherapy after resection/ablation of their metastatic lesion, as standard practice. in such cases, the patient may be enrolled onto this study at the discretion of the local principle investigator once the metastasis has been treated. * inability to attend full course of radiotherapy of follow-up visits * pregnant or lactating women
comparison of drainage methods in minimally invasive esophagectomy (demure）

Conditions: Esophageal Cancer; Drainage/Methods; Postoperative Pain

Summary: this rct compares three drainage approaches after minimally invasive esophagectomy (chest tube + thoracic mediastinal drainage tube, thoracic, and abdominal mediastinal drainage tube) to evaluate perioperative outcomes, addressing current evidence gaps in pain and complication profiles.


Eligibility criteria:
inclusion criteria: * age ≥18 years * pathologically confirmed esophageal cancer requiring three-incision esophagectomy (cervical, thoracic, and abdominal incisions) * asa physical status class i-iii exclusion criteria: * history of chronic pain or long-term use of analgesics prior to surgery * severe cardiopulmonary dysfunction (e.g., fev1 \<50%) * coagulation disorders or patients undergoing reoperation * intraoperative findings of extensive pleural adhesions, combined resection of adjacent organs, or other conditions deemed by the investigator to warrant exclusion

Keywords: esophageal cancer mediastinal drainage tube postoperative pain
irinotecan in treating patients with recurrent glioma

Conditions: Brain and Central Nervous System Tumors

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. purpose: phase ii trial to study the effectiveness of irinotecan in treating patients who have recurrent glioma.

objectives: i. determine the efficacy of irinotecan in the treatment of patients with recurrent glioma. ii. assess the toxicities of irinotecan in these patients. iii. correlate the pharmacological parameters with toxicity and response to therapy. outline: this is a two arm study. patients are stratified according to prior nitrosourea administration. patients are assigned to 1 of 2 arms, with only 1 arm being open at any time. patients assigned to arm i receive irinotecan iv over 90 minutes on days 1, 8, 15, and 22. this is followed by a 2 week rest and continues for a maximum of 6 courses. patients assigned to arm ii receive irinotecan on day 1 every 3 weeks for up to 12 courses. patients in both arms who received prior nitrosoureas receive reduced starting doses of irinotecan. the dosages may be increased once per patient after the first course if toxic effects are acceptable. arm i closed as of 10/98, arm ii open as of 10/98. patients are followed every 3 months for the first year, every 6 months for the next 4 years, then annually until death.

Eligibility criteria:
disease characteristics: histologically proven primary brain glioma astrocytoma gliosarcoma oligodendroglioma oligoastrocytoma tumor progression by ct scan or mri following radiotherapy measurable or evaluable disease patient characteristics: age: 18 and over performance status: ecog 0-2 life expectancy: not specified hematopoietic: absolute neutrophil count at least 1500/mm3 platelet count at least 100,000/mm3 hemoglobin at least 9 g/dl hepatic: bilirubin no greater than 1.5 mg/dl ast no greater than 3 times upper limit of normal no prior gilbert's syndrome renal: creatinine no greater than 2.0 mg/dl cardiovascular: no history of myocardial infarction within 6 months no congestive heart failure requiring therapy other: no concurrent active second malignancy no uncontrolled infection no other severe concurrent disease not pregnant or lactating fertile patients must use effective contraception prior concurrent therapy: biologic therapy: not specified chemotherapy: no more than 1 prior adjuvant chemotherapy regimen and 1 for recurrence (gliadel is considered 1 regimen) at least 4 weeks since prior chemotherapy at least 6 weeks since prior nitrosoureas no prior irinotecan, topotecan, or aminocamptothecin endocrine therapy: at least 2 weeks on fixed dose of corticosteroids (or no corticosteroids) prior to baseline scan radiotherapy: at least 8 weeks since prior radiotherapy surgery: no surgical resection between last radiotherapy or chemotherapy and study therapy, unless unequivocal tumor growth since surgery

Keywords: recurrent adult brain tumor adult brain stem glioma adult oligodendroglioma adult mixed glioma adult diffuse astrocytoma
follow-up of the prevision® hip stem

Conditions: Periprosthetic Fracture Around Prosthetic Joint Implant; Aseptic Loosening of Prosthetic Joint

Summary: the main objective of this study is to represent the treatment reality at the study site and to draw conclusions from cases of failure or suboptimal outcome. potential risk factors for revision surgery, suboptimal outcome or radiologic sign of loosening, bone non-union or stem subsidence will be evaluated. next to the functional outcome, stem subsidence will be used as an important indicator for a stable fixation of the revision stem.


Eligibility criteria:
inclusion criteria: * all patients implanted with a prevision® hip stem at the study site between 2014 and 2019 * written informed patient consent exclusion criteria: - patients \< 18 years at surgery

Keywords: arthroplasty, replacement, hip implant failure failed primary hip arthroplasty severe bone defects complex bone fractures septic loosening poor bone remodeling
oct-guided dsaek graft shaping and smoothing

Conditions: Fuchs' Endothelial Dystrophy

Summary: the primary goal of this study is to determine if excimer laser smoothing of the cornea before descemet's stripping automated endothelial keratoplasty (dsaek)improves postoperative best spectacle corrected visual acuity (bscva).

many surgeons are moving away from full thickness corneal transplantation (because of risks involving rejection, irregular astigmatism, and wound dehiscence) to partial thickness transplantations of either the anterior or posterior (endothelial) layers. however this technique is not without its drawbacks. dsaek uses a mechanical microkeratome to cut the graft, but vision is limited by the roughness of the cut surface. dsaek can lead to significant refractive error due to the non-uniform shape of the microkeratome cut graft, and the roughness of the microkeratome cut surface limits vision to an average of 20/31. optical coherence tomography (oct)-guided laser shaping and smoothing may improve the refractive and visual outcome.

Eligibility criteria:
inclusion criteria: * adults with visual complaint and objective evidence of decreased vision due to corneal edema related to fuchs' corneal endothelial dystrophy exclusion criteria: * inability to give informed consent * inability to maintain stable fixation for oct imaging * inability to commit to required visits to complete the study * eyes with concurrent cataract, retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery

Keywords: fuchs' endothelial dystrophy dsaek descemet's stripping automated endothelial keratoplasty