Kornimate/medical-research-clean huggingface dataset:
erythrocyte complement receptor 1 and alzheimer disease

Conditions: Alzheimer Disease

Summary: main objective: investigate whether a functional polymorphism of cr1 (length, number of binding sites in c4b c3b, erythrocyte density, rate of soluble cr1 ...) so determined genetic or acquired, is a susceptibility factor for the disease alzheimer's.


Eligibility criteria:
inclusion criteria: * caucasians people with a alzheimer dementia defined on dsmiv criteria for patients and without alzheimer disease for control subjects exclusion criteria: * diseases modifying cr1 physiology
the children and adolescents nasopharyngeal carcinoma survivor study

Conditions: NPC Patients

Summary: the children and adolescents nasopharyngeal carcinoma survivor study will investigate the long-term effects of nasopharyngeal carcinoma (npc) and its associated therapies. a prospective and retrospective cohort study will be conducted through a multi-institutional collaboration. this project will study children and adolescents exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. a group of sibling controls will be identified and data collected for comparison purposes.

the study will focus on the following objectives: * characterize survivors' health with respect to disease- and treatment-related factors. * investigate the consequences of various intensities of exposure to chemotherapy and/or radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers, etc...). * compare the mortality experience of survivors with the general population. * characterize the health-related behaviors, patterns of medical care, and medical follow-up needs of survivors. * describe patterns of familial aggregation of cancer, including known (and variations of) cancer family syndromes. * collect and store biologic samples (saliva, blood, second tumor tissue) to correlate with health outcomes and use for future research.

Eligibility criteria:
inclusion criteria: * patients or their siblings must be informed of the investigational nature of this study and give written informed consent. * patients with histologically confirmed non-keratinizing nasopharyngeal carcinoma (including differentiated type and undifferentiated type, who ii or iii) before age 21 years at one of participating centers. exclusion criteria: * already involved in other blind clinical trial. * the information of tumour response evaluation and survival data cannot be obtained.

Keywords: children and adolescents
a study of neoadjuvant/adjuvant durvalumab for the treatment of patients with resectable non-small cell lung cancer

Conditions: Non-Small Cell Lung Cancer

Summary: this is a phase iii, randomized, double-blind, placebo-controlled, multi-center international study assessing the activity of durvalumab and chemotherapy administered prior to surgery compared with placebo and chemotherapy administered prior to surgery in terms of pathological complete response.


Eligibility criteria:
inclusion criteria: * age ≥18 years * newly diagnosed and previously untreated patients with histologically or cytologically documented nsclc with resectable (stage iia to select \[ie, n2\] stage iiib) disease * world health organization (who)/ecog ps of 0 or 1 at enrollment * at least 1 lesion, not previously irradiated, that qualifies as a recist 1.1 target lesion (tl) at baseline * no prior exposure to immune-mediated therapy including, but not limited to, other anti-ctla-4, anti-pd-1, anti-pd-l1, and anti-pd-l2 antibodies, excluding therapeutic anticancer vaccines * adequate organ and marrow function * confirmation of a patient's tumour pd-l1 status * provision of sufficient tumour biopsy sample for evaluation and confirmation of egfr and alk status * planned surgery must comprise lobectomy, sleeve resection, or bilobectomy exclusion criteria: * history of allogeneic organ transplantation * active or prior documented autoimmune or inflammatory disorders (including inflammatory bowel disease, diverticulitis, systemic lupus erythematosus, sarcoidosis syndrome, or wegener syndrome) * history of another primary malignancy * history of active primary immunodeficiency * active infection including tuberculosis hepatitis b and c, or human immunodeficiency virus * deemed unresectable nsclc by multidisciplinary evaluation * patients who have pre-operative radiotherapy treatment as part of their care plan * patients who have brain metastases or spinal cord compression * stage iiib n3 and stages iiic, iva, and ivb nsclc * known allergy or hypersensitivity to any of the study drugs or excipients * existence of more than one primary tumour such as mixed small cell and nsclc histology * patients whose planned surgery at enrollment includes any of the following procedures: pneumonectomy, segmentectomies, or wedge resections * patients with a documented test result confirming the presence of egfrm or alk translocation

Keywords: resectable non-small cell lung cancer, nsclc, carcinoma, non-small cell lung cancer
the effect of postoperative "peanut ball" rehabilitation after total knee replacement.

Conditions: Knee Osteoarthritis

Summary: the purpose of this randomized controlled study is to evaluate the effect of postoperative exercise with a "peanut ball" after total knee replacement, on pain, intake of pain killers, knee function, and health-related quality of life.

after being informed about the study and potential risks, all patients giving written informed consent will be included in the study. at baseline, before surgery, all patients will meet a nurse, a physical therapist, and an orthopedic doctor and answer questions about their health condition and do functional tests. each week is randomized to be either "peanut ball" or standard exercise week, with all patients during that week receiving the same treatment. thus, depending on what week the patients are operated they will be mobilized with postoperative exercise with a "peanut ball" or to a standard exercise program (no peanut ball) 3-5 times/day for 6 weeks. all patients randomized to exercise with a "peanut ball" will receive a ball for free to bring home. at the ward, the nurses will ask about the patient's pain level two times a day and register all medicines. the physical therapist will introduce the exercise and inform the patients to do the exercise 3-5 times/day a´ 15 minutes and fill in all exercises in an exercise diary. 2 weeks after surgery all patients have a standard visit to a nurse and a physical therapist at the orthopedic department. at this visit, the nurse will register the pain level and all intake of medicine and the physical therapist will measure the range of movement and the sit to stand test. 3 months after surgery all patients have a standard visit to a physical therapist at the orthopedic department. at this visit, all outcomes will be filled in or measured.

Eligibility criteria:
inclusion criteria: * patients with osteoarthritis planned for surgery with total knee replacement at skåne university hospital. exclusion criteria: * patients who do not understand and talk the swedish language * patients with dementia * revision surgery of the knee * unicompartmentmental knee replacement
a study comparing monthly boniva (ibandronate) and weekly risedronate in women with post-menopausal osteoporosis.

Conditions: Post Menopausal Osteoporosis

Summary: this 2 arm crossover study will evaluate patient reported preference for either once monthly boniva (150mg p.o.) or once weekly risedronate (35mg p.o.). patients with post-menopausal osteoporosis will be randomized to receive boniva for 3 calendar months or risedronate for 12 weeks; they will then cross over to receive the alternative treatment for a further 12 weeks/3 months. the anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals.


Eligibility criteria:
inclusion criteria: * ambulatory women with post-menopausal osteoporosis; * patients who are bisphosphonate-naive, or who have previously received oral daily or i.v. bisphosphonate therapy (fulfilling certain criteria detailed in the protocol). exclusion criteria: * malignant disease diagnosed within previous 10 years (except for successfully resected basal cell cancer;) breast cancer within previous 20 years; * inability to stand or sit upright for at least 60 minutes; * disease/disorder/treatment with drugs known to influence bone metabolism.
prevalence of osteoporosis among inflammatory bowel disease patients in assiut university hospitals

Conditions: Osteoporosis

Summary: the prevalence of osteoporosis in patients with inflammatory bowel disease in assiut university hospitals.

inflammatory bowel disease (ibd) includes ulcerative colitis (uc) and crohn's disease (cd) (1) .there has been a global rise in the incidence of ibd over the last few decades. (2) in the course of this disease, apart from the involvement of the gastrointestinal tract, up to 50% of patients may also have extraintestinal manifestations (eims) .one of them may be osteoporosis (ost), which is present in over half of ibd patients; this constitutes a significant problem due to the increased risk of fractures, especially non-traumatic fractures.(3) known risk factors for ost in ibd include the persistence of chronic inflammation, treatment with glucocorticosteroids, extensive range of the disease, previous resection of the small intestine, arthralgia, and current nutritional deficiencies. some risk factors are similar to those found in the general population, such as age, smoking, or low physical activity.(3) the pathogenesis of osteoporosis is multifactorial and comprises such elements as steroid therapy, low body mass index (bmi), malnutrition, genetic predispositions, and vitamin d deficiency (4) given that the gastroenterologist is often regarded as the main provider for ibd patients, gastroenterologists and primary care physicians are equally responsible to recommend preventive measures and screening for osteoporosis, in addition to other healthcare maintenance issues.(5) dual energy x-ray absorptiometry (dexa) scans are globally recognised as the screening tool for low bmd (6) the z and t scores are used to establish the diagnosis of osteoporosis, osteopenia or low bmd according to the 2019 international society of clinical densitometry official position for adults.(7)

Eligibility criteria:
inclusion criteria: * the study will include patients aged 18-65 years, diagnosed with either crohn's disease or ulcerative colitis, the diagnosis of uc and cd based on the clinical, endoscopic, laboratory and histological criteria according to ecco guidelines. the activity of ibd will be determined with the use of the crohn\&#39;s disease activity index (cdai) for cd, and the mayo score for uc, data collection will obtained over one year duration exclusion criteria: 1. patients known to have osteoporosis and on treatment 2. female patients on cocs 3. patients with malignancy 4. patients with ckd

Keywords: prevalence of osteoporosis among inflammatory bowel disease patients in assiut university hospitals.
hi-fatigue g bone cement retrospective study

Conditions: Total Hip and Knee Arthroplasties

Summary: the objective of this retrospective monocentric study is to collect survivorship and clinical data confirming safety, performance and clinical benefits for the hi-fatigue g bone cement. the assessments will include: * radiological analysis performed at different time points according to the standard of care of the hospital * implant survivorship and safety based on removal of a study device * patient reported outcome measures (proms) primary endpoint: assessment of radiolucent lines around the components (tibial, femoral, acetabular) at 5 years (in accordance with the hospital standard of care). secondary endpoints: * evaluation of implant survivorship and safety by monitoring the frequency and incidence of adverse events. relation of the events to implant, instrumentation and/or procedure should be specified. * evaluation of proms * obtain information regarding the cementing technique and handling of the cement, if available


Eligibility criteria:
inclusion criteria: * subject qualified for cemented tka or tha with a zimmer biomet implant * subject is willing and able to give written informed consent for retrospective data collection and undergo interim and final evaluation (x-ray \& scores completion) * subject \> 18 years old exclusion criteria: * muscle wasting * neuromuscular compromise in the affected limb * known hypersensitivity to any of the cement constituents * subjects with severe renal failure * bilateral interventions * subject is a vulnerable subject (prisoner, mentally incompetent or unable to understand what participation to the study entails, known alcohol or drug abuser, anticipated to be non-compliant)

Keywords: bone cement knee arthroplasty hip arthroplasty
nac in cc resistant pcos after lod

Conditions: Clomiphene Citrate Resistant Polycystic Ovary Syndrome

Summary: this prospective randomized placebo-controlled double blind clinical trial will conducted in ain shams university maternity hospital including 120 women diagnosed with clomiphene citrate resistant polycystic ovary syndrome. after laparoscopic ovarian drilling, they will be randomized to either receiving 50 mg oral clomiphene citrate twice daily and oral nac 1,200 mg/day for 5 days starting from cycle day 2 to cycle day 6 (group 1 = 60 patients) or clomiphene citrate only (group 2 = 60 patients). the primary outcome will be biochemical pregnancy rate, secondary outcomes include clinical pregnancy rate, ovulation rate, live birth rate, number of follicles ≥ 18 mm and endometrial thickness at triggering ovulation, mid- luteal sub-endometrial blood flow indices, and incidence of side effects.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) between 25 and 30 kg/m 2. * cc-resistant polycystic ovary syndrome exclusion criteria: * • patients with bmi under 25 or over 30 kg/m 2. * hyper or hypothyroidism, or hyperprolactinemia. * current or previous (within the last six months) use of oral contraceptives, glucocorticoids, antiandrogens, antidiabetic and anti-obesity drugs or other hormonal drugs. * intention to start a diet or a specific program of physical activity. * organic pelvic diseases. * tubal or male factor infertility. * interval of earlier treatment with any of the fertility drugs of less than 6 months. * contraindication to either: * clomiphene citrate: liver disease, undiagnosed abnormal uterine bleeding, uterine fibroids, endometrial cancer, ovarian enlargement or hyper stimulation * hcg injection: ovarian enlargement or hyper stimulation

Keywords: polycystic ovary syndrome n-acetyl-cysteine clomiphene citrate clomiphene citrate resistant laparoscopic ovarian drilling therapy
femoral tunnel position on conventional mri after anterior cruciate ligament reconstruction-transtibial technique versus transportal technique

Conditions: Anterior Cruciate Ligament Rupture

Summary: the position of the femoral tunnel in anterior cruciate ligament (acl) reconstruction has been assessed on three dimensional ct (3d-ct) scan or in cadaveric study. however, these methods have some issues; 3d-ct scan has a concern on radiation exposure and cadaveric study is not easily available nor an in vivo test. the purpose of this study is to compare the position of the femoral tunnel aperture on conventional mri and the outcomes after single bundle acl reconstruction using free tendon achilles allograft between transportal technique and transtibial technique in active young men.


Eligibility criteria:
inclusion criteria: * diagnosis of anterior cruciate ligament rupture exclusion criteria: * female * over 45 years old * the subjects who had acl reconstruction with graft other than achilles allograft * the subjects who had concomitant other ligament injuries on the same knee needing surgical treatment * revision acl reconstruction * double bundle acl reconstruction * concomitant full thickness cartilage injury needing cartilage repairing surgery
validation of ultrasound as a diagnostic tool for assessment of hemophilic arthropathy of knees and ankles

Conditions: Hemophilia; Hemophilic Arthropathy

Summary: the purpose of this study is to test the external validity of the systemic ultrasound protocol for data acquisition and interpretation, in order to diagnose soft tissue and osteochondral abnormalities in hemophilic children.

ultrasound has advantages over mri as it is less expensive, does not require sedation and is more readily available in centres around the world. given these characteristics of ultrasound it is an ideal imaging tool for early assessment of hemophilic joints in countries whose access to mri is limited. early evaluation of soft tissue changes in young hemophilic patients may lead to earlier interventions and better mid-term and long-term clinical outcomes. by this way the joint function of hemophilic patients can be preserved, saving their joints from severe arthropathy and offering them the possibility of a normal professional life in the society.

Eligibility criteria:
inclusion criteria: * diagnosis of hemophilia a (factor viii deficiency ≤1%) or b (factor ix deficiency ≤1.0%) * cooperative patients (age of 7 to 18 years old) * patients under 7 years old who have clinical evidence of arthropathy and imaging studies are required for clinical reasons. in these cases, the procedures may be done under sedation. * male sex (higher prevalence in males) * history of previous ankle or knee bleed exclusion criteria: * co-morbid illness such as juvenile idiopathic arthritis, muscular dystrophy, neuropathic arthropathy that cause osteoarticular findings that may obscure or confound the hemophilia-based joint findings * non-cooperative patients * active bleed (defined as evidence of a recent bleed with one week of the proposing imaging studies and/or musculoskeletal changes on physical examination suggestive of a bleed within one week of the proposed imaging studies). * prior synovectomy

Keywords: pediatrics haemophilia ultrasound mri arthropathy
pregnancy and neonatal follow-up of ongoing pregnancies established in clinical trial p05714 (care program)(p05715)

Conditions: Pregnancy; Neonates

Summary: the objective of this trial is to evaluate whether corifollitropin alfa (org 36286) treatment for the induction of multifollicular growth in women undergoing controlled ovarian stimulation (cos) prior to in vitro fertilization (ivf) or intracytoplasmic sperm injection (icsi) is safe for pregnant participants and their offspring. in addition, a primary efficacy variable, live birth rate, was evaluated.

this is a follow-up protocol to prospectively monitor pregnancy, delivery, and neonatal outcomes of women who were treated with corifollitropin alfa and became pregnant after fresh embryo transfer during the base study p05714 (nct00696878). for this trial, no study specific assessments are required, but information as obtained in standard practice will be used.

Eligibility criteria:
inclusion criteria: * participants who participated in base study p05714 (nct00696878) and received at least one dose of corifollitropin alfa in base study p05714; * ongoing pregnancy confirmed by ultrasound at least 10 weeks after a fresh embryo transfer in base study p05714; * able and willing to give written informed consent. exclusion criteria: * none

Keywords: neonatal outcome congenital malformations in-vitro fertilization controlled ovarian stimulation follow-up
lung ultrasound signs and patterns in covid-19 pregnant women

Conditions: Pregnancy Complications; Covid19

Summary: sars-cov-2 impact on pregnant women is not well known yet. some authors demonstrated that lung ultrasound can give similar results if compared to chest computed tomography and better results if compared to chest x-rays without radiations and limited risks for mother and fetus. the lung ultrasound score (lus) can be used to asses the entity and monitor the evolution of lung impairment. some authors described an artifact, the "light beam", as a typical ultrasound sign in covid-19 positive patients. with our study we hypothesize to understand the prevalence of this sign and other ultrasound signs in pregnant covid-19 positive patients.


Eligibility criteria:
inclusion criteria: * all pregnant covid 19 positive patients admitted at our institution who had lung ultrasound performed exclusion criteria: * are \< 18 years old * history of rheumatic disease * history of spontaneous pneumothorax * fibrothorax * history of thoracic surgery * no consent given
aerobic training in pregnant women with gestational diabetes and chronic hypertension

Conditions: Pregnancy; Gestational Diabetes Mellitus; Chronic Hypertension in Obstetric Context

Summary: the aim of the present study is verify glycated hemoglobin (hba1c) and homa behavior in pregnant women with gestational diabetes or chronic hypertension after an aerobic training in cycle-ergometer. the sample is composed by 64 pregnant and sedentary women, 20 weeks' pregnant. two experimental groups (gestational diabetes and chronic hypertension, n = 16 each) will perform a low-intensity aerobic training in cycle-ergometer, three times/week, for 45 minutes each session. two control groups (gestational diabetes and chronic hypertension, n = 16 each) will perform an unique session/week of relaxation and stretching. outcomes: first ventilatory threshold, hba1c,homa, type of delivery, weight and height of the newborn.

the statistical analysis will consist of: * descriptive statistic; * levene's test * shapiro wilk's normality test * parametric or non-parametric test * a=0.05 * spss 17.0

Eligibility criteria:
inclusion criteria: * age \> 20 years; * gestational age between 20 and 27 weeks (date of the last period and confirmed by ultrasound); * only one foetus in the womb; * without orthopedic limitations; * non-smoker; * medical clearance for exercise exclusion criteria: * pre-eclampsia; * fetal malformations; * intrauterine fetal death

Keywords: glycated hemoglobin homa pregnancy aerobic exercise
comparative evaluation of post-endodontic pain using two rotary instrumentation systems

Conditions: Pain

Summary: in this study the investigators aim to compare the post-operative pain using two single-file endodontic rotary systems : reciproc and one shape.

comparison of the post operative pain with two rotary systems including reciproc and one shape. confounding factors were neutralized and the rotary systems were compared.

Eligibility criteria:
inclusion criteria: * systematically healthy patients * first or second molars with irreversible pulpitis without periapical pathosis. * single visit endodontic treatment exclusion criteria: * root canal retreatment * pregnancy * the presence of a difficult root canal anatomy * internal or external resorption * teeth with open apices * any accident of complication occurred during treatment * presence of periapical lesion, abscess or sinus tract

Keywords: root canal treatment pain endodontic instruments