Kornimate/medical-research-clean huggingface dataset:
bic: evaluation of the current care processes for stroke care in flemish hospitals

Conditions: Stroke, Ischemic

Summary: different studies showed large variation between care processes in multiple diseases, which lead to large variation in outcomes. better adherence to evidence-based guidelines for these diseases can reduce this variation and can improve the health outcomes. since international studies have demonstrated wide variations in care processes for acute stroke, it would be interesting to repeat these investigations in the population of stroke patients. worldwide, stroke is a leading cause of disability and death. every two seconds, someone across the world experiences a symptomatic stroke. 50% of stroke survivors has moderate to severe neurologic deficits, 25% of them depend on others. in belgium, stroke is one of the most important causes of invalidity. every year approximately 18 000 people in belgium experiences a stroke, which results in almost one person every two hours, with a mortality rate of 30%. the world health organization has the ambition to significantly reduce the mortality and risk factors for non-communicable diseases by 2025. the mortality and disability in stroke patients can be reduced by organized stroke care, which includes effective strategies in stroke management, treatment and prevention. also, other health domains, like functional recovery, healthcare costs and patient satisfaction, were positively related to adherence on stroke guidelines. this evidence had been converted in several clinical guidelines for stroke care. however, the adherence to these guidelines is variable. as already mentioned before, international studies have demonstrated wide variations in care processes for acute stroke. however, a positive relationship has been shown between the implementation of evidence-based clinical guidelines and the quality of stroke care. therefore, it is important to both implement these guidelines and to improve the adherence to them. the aim of this study is to map the variation in stroke care in flemish hospitals and to get an overview about the variation within and between these hospitals. during this study, electronic patient records will be analyzed to check which interventions are performed in a specific patient and of which no information could be found in de patient record.


Eligibility criteria:
inclusion criteria: * minimum age of 18 years * admitted to the emergency department and diagnosed with an ischemic stroke exclusion criteria: * diagnosed with cerebral venous thrombosis * diagnosed with hemorrhage * thrombectomy performed
diabetic foot ulcer prevention system

Conditions: Diabetic Foot

Summary: to evaluate a recently developed non-invasive infrared thermal camera called diabetic foot ulcer prevention system (dfups) in a clinical setting by studying healthy volunteers.


Eligibility criteria:
inclusion criteria: 1. aged 18 years or older 2. has no history of diabetes 3. has no previous history of foot ulceration 4. has no previous history of foot surgery 5. has palpable foot pulses on both feet (palpable posterior tibial artery pulse or dorsalis pedis artery pulse or both) 6. has no history of peripheral neuropathy 7. has no history of peripheral arterial disease 8. must be able to provide meaningful written informed consent for the study exclusion criteria: 1. has active foot ulceration and infection 2. has foot deformity which in the opinion of the investigator, would interfere with interpreting the results of the study 3. has any uncontrolled illness that, in the opinion of the investigator, would interfere with interpreting the results of the study 4. has an implantable electronic device 5. is aged \<18
oral health intervention pilot study for individuals with memory problems

Conditions: Mild Cognitive Impairment

Summary: the purpose of this study is to pilot test an intervention to improve oral health for individuals with memory problems. the results from this study will assist in developing prevention and intervention programs aimed at maintaining good oral health, or at least slowing its deterioration.

this project will involve two phases. the main purpose of phase 1 is to conduct a focus group with 6 individuals with mild dementia (imds) and their live-in partners (usually spouse) and conduct in-depth interviews with staff at community organizations (e.g., dementia caregiver support group staff) to develop the protocol. information from phase 1 will provide input to refine the proposed pilot intervention that will be phase 2 of this project. the pilot oral health intervention will last 6 months and will be conducted with up to ten imds and their live-in partners.

Eligibility criteria:
inclusion criteria: * a diagnosis of mild dementia within the past year. * have at least four natural teeth. * 60 years and older. * living with an informal caregiver who is willing to participate. * community-dwelling * physically able to brush own teeth. exclusion criteria: * edentulism * unable to have an oral health evaluation done. * sensory or physical problems that prevent participation in the intervention. * terminal illness or hospitalization for a psychiatric disorder in the prior year.
cooking for health optimization with patients

Conditions: Cardiovascular Diseases; Cardiovascular Risk Factor; Nutrition Disorders; Diabetes; Hypertension; Cancer; Depression; Obesity; Physical Activity

Summary: cooking for health optimization with patients (chop) is the first known multi-site prospective cohort study with a nested bayesian adaptive randomized trial in the preventive cardiology field of culinary medicine. it is also the first known longitudinal study to assess the impact of hands-on cooking and nutrition education on patient outcomes, with those classes taught by medical students and other future and current medical professionals who have first been trained in those classes on how to integrate diet and lifestyle counseling of patients with their respective scopes of clinical practice. chop is the primary research study of the world's first known medical school based teaching kitchen, the goldring center for culinary medicine at tulane university school of medicine. medical trainees and professionals are followed in this study long-term to understand how the classes impact their competencies in patient counseling, attitudes about the counseling, and their own diets. patients who consent to being randomized to these classes compared to standard of care are studied within the nested bayesian adaptive randomized trial to understand how the classes impact their health outcomes, clinical and food costs, and the costs of health systems caring for these patient populations. chop is designed as a pragmatic population health trial to hopefully improve healthcare effectiveness, equity, and cost by establishing an evidence-based, scalable, sustainable model of healthcare intervention targeting the social determinants of health, while complementing the pharmacological and/or surgical management of patients.


Eligibility criteria:
inclusion criteria: * 7 to 115 years of age (patients), and currently a medical trainee or professional (including for physicians, nurses, physician assistants, and dieticians) exclusion criteria: * inability to complete at least 2 intervention classes
prevalence of nafld in t2dm patients

Conditions: NAFLD; T2D; Type 2 Diabetes; Fatty Liver, Nonalcoholic

Summary: to determine the prevalence of non-alcoholic fatty liver disease (nafld) in patients with type 2 diabetes mellitus (t2dm).


Eligibility criteria:
inclusion criteria: * ≥ 18 years of age * having type 2 diabetes mellitus (t2dm) * written informed consent obtained exclusion criteria: * excessive alcohol use * exclusion of other causes of liver disease and secondary causes of steatosis
faecal microbiota transplantation in ulcerative colitis

Conditions: Ulcerative Colitis; Inflammatory Bowel Disease

Summary: the purpose of this study is to determine whether fecal microbiota transplantation (fmt) is safe and efficacious in the treatment of chronic active ulcerative colitis (uc) by conducting a randomised controlled trial

this study involves the assessment of the safety and efficacy of fmt in the treatment and induction of remission for patients with mild to moderate ulcerative colitis. it is a double blind study with patients randomised in a 1:1 manner to either active or placebo therapy

Eligibility criteria:
inclusion criteria: * ulcerative colitis \>3 months duration * active mild-moderate ulcerative colitis (mayo 4-10) * ulcerative colitis of any extent except isolated proctitis \< 5cm * live within driving distance of clinical site (to attend multiple study visits) exclusion criteria: * pregnancy * active gastrointestinal infection * other gastrointestinal disease / comorbidities * prior colonic surgery * recent antibiotic or probiotic use * prednisone \> 20mg * monoclonal antibody immunosuppressive therapy

Keywords: ulcerative colitis inflammatory bowel disease fecal transplantation fecal microbiota transplantation
psycho-education program blame-less and it's effect on traumarelated shame and guilt

Conditions: Trauma

Summary: the primary objective of the blame-less study is to examine the effectiveness of an online psychoeducation program in reducing trauma-related feelings of shame and guilt in adolescents who experienced sexual or physical abuse .

the study follows a two-arm rct (n=34). the effects of a brief online psychoeducation program will be compared, with a waiting-list control group. the intervention aims to reduce feelings of trauma-related shame and guilt that adolescents experience regarding their own defense responses during and after (sexual) violence. assessments take place after screening, at baseline, two weeks after allocation to the intervention or waiting-list, and, only for the waiting-list participants, seven weeks after allocation to the intervention.

Eligibility criteria:
inclusion criteria: * the participant experienced one or more traumatic life events, including (sexual) violence as indicated by the ctsq; * the participant reported one or more feelings of guilt and/or shame on the cerq (items 1 and/or 10 and/or 19 and/or 28) * the participant being fluent in written and spoken dutch; * the participant is motivated and available for a period of seven weeks to engage in the study, including the psychoeducation program blame-less, and commit to the assessments. exclusion criteria: * acute suicidal behavior or suicidal ideations requiring immediate hospitalization; * the participant has already read the book that this program is based upon: "paralyzed with fear" (in dutch: verlamd van angst, van minnen 2017), or has been intensively informed otherwise in the past 12 months by a psychologist about common defense responses during and after trauma; * cognitive impairments (iq \< 70); * the participant has a brother or sister in the present study; * the participant is already involved in trauma-focused treatment.

Keywords: shame guilt defense response defense cascade ptsd psycho-education tonic immobility appeasement
fortified hospital food as nutritional support

Conditions: Malnutrition

Summary: background: the investigators have previously documented that patients at nutritional risk lack sufficient energy and protein intake. in 2009 the investigators conducted a non-randomized historically controlled intervention study of 40 patients at nutritional risk. the study indicated that a tailored food concept increased nutritional intake in this patient group. the objective of the current study is therefore to investigate these findings in a randomized clinical trial. our target is for 75% of patients in the intervention group to reach 75% of their energy and protein requirements. methods: the study will compare standard nutritional care (control group) with tailored nutritional care (the possibility to order small energy and protein-enriched dishes called "delights of herlev hospital"). 96 patients at nutritional risk, according to the nrs-2002 criteria, will be included in the study.


Eligibility criteria:
inclusion criteria: * patients at nutritional risk, according to the nrs-2002 system * patients must be able to understand the information and be able to give a written informed consent (sufficient cognitive functioning) * well-functioning gastrointestinal tract * anticipated length of hospitalization of more than 3 days exclusion criteria: * terminal patients * dysphagia * food allergy or intolerance

Keywords: nutritional risk, hospital food, nutritional intervention
the effect of semiconductor knee sleeves on pain in osteoarthritis of the knee.

Conditions: Osteo Arthritis Knee

Summary: to assess the benefits of using semiconductor (germanium and carbon) woven knee sleeves products in patients with osteoarthritis of the knee. to compare patients in a blinded randomized trial with and without the semiconductor knee sleeves product during the first 3 months period after initial contact at the outpatient clinic. aims: the hypothesis of the study is that the semiconductor sleeve will reduce pain and improve knee function in active group when compared to the placebo group.

semiconductor woven knee sleeves work by increasing circulation to reduce inflammation, relieve pain, optimize performance, and accelerate recovery. unlike compression products, semiconductor knee sleeves do not need to compress to work. instead, the technology incorporates the semiconductor elements germanium and carbon within the fabric, which when stimulated by body heat, by release of negative ions. the negative ions activate molecular vibrations that increase blood flow and speed. increasing circulation helps bring more oxygen and nutrients to the target area, which optimizes the body's natural healing process and accelerates recovery. benefits of increased blood circulation include: * accelerated recovery * reduced swelling * optimized performance * reduced fatigue * thermoregulation investigators wish to investigate a possible effect on knee pain and function in patients with osteoarthritis of the knee. subject enrollment: subjects referred with arthrosis of the knee to the out-patient clinic, at the hip- and knee-arthroplasty unit, herlev gentofte hospital. included subjects must be assessed by an arthroplasty surgeon to have arthrosis without present indication for surgery, and to be eligible for a period of conservative treatment including physiotherapist guided training and paracetamol treatment. this is a prospective study that will require informed consent. study size calculation a 25% difference in pain reduction between the intervention group compared and the placebo group is considered clinically relevant. standard deviation expected at 25 mm on a 100 mm visual analog scale (vas) for pain1. a type ii error set at 10%, and a two-sided 5% significance level. a total number of 36 subjects with 18 in each group was calculated. to account for dropouts and the risk of conversion to surgical strategy during the follow-up period we plan to enroll a total of 25 subjects in each group. study population: estimated enrollment target enrollment - 50 patients * 25 patients with the semiconductor knee sleeve. * 25 patients with the placebo sleeve.

Eligibility criteria:
inclusion criteria: * arthrosis of the knee * surgery not yet indicated * 40-90 years old * male or female * compliant patient * bmi less than 35 * able to understand danish sufficiently for written consent exclusion criteria: * rheumatoid arthritis * previous blood clots * bmi greater than 35 * varicosities on operative leg

Keywords: knee arthrosis pain osteoarthritis knee-sleeves semiconductor
"cancersensor": circadian rhythms

Conditions: Metastatic Colorectal Cancer

Summary: observational, non randomized study aimed at measuring the circadian rhythms in the urinary concentrations of physiological modified nucleosides in 30 patients with metastatic colorectal cancer and in 30 age and sex-matched healthy subjects.


Eligibility criteria:
inclusion criteria for patients: * histologically-confirmed metastatic colorectal cancer; * 0 to 3 prior chemotherapy lines; * signed informed consent; * good understanding of the protocol and of the follow-up; * estimated life expectancy exceeding 3 months; * at least one measurable metastatic lesion (recist criteria); * performance status (who) of 0 to 2; * good haematological, hepatic and renal functions. inclusion criteria for healthy subject * age ≥ 18 ans * signed informed consent; * good understanding of the protocol and of the follow-up; * good haematological, hepatic and renal functions. * test hiv and b and c hepatitis negative test * no chronic or acute diseases exclusion criteria for patients: * poor performance status (\>2); * poor haematological, hepatic or renal functions; * uncontrolled chronic disease; * serious unhealed wound, ulcer or fracture within the previous month; * clinical or laboratory finding suggesting possible abnormalities in nucleosides urinary excretion; * pregnancy or breast-feeding during the previous month; * transmeridian trip of more than 4 time zones within the prior 2 weeks; * person with legal restriction to participate into clinical research, according to the current law in france. exclusion criteria for healthy subject: * poor haematological, hepatic or renal functions; * uncontrolled chronic disease; * serious unhealed wound, ulcer or fracture within the previous month; * clinical or laboratory finding suggesting possible abnormalities in nucleosides urinary excretion; * pregnancy or breast-feeding during the previous month; * transmeridian trip of more than 4 time zones within the prior 2 weeks; * person with legal restriction to participate into clinical research, according to the current law in france.

Keywords: colorectal cancer metastatic healthy control circadian urine nucleosides
effect of i/r injuries by pringle manoeuvre on the prognosis of hcc patients after curative hepatectomy

Conditions: Hepatocellular Carcinoma

Summary: this is a multi-centre prospective randomized controlled trial to explore the influence of ischemia-reperfusion injuries elicited by pringle manoeuvre during radical excision on the prognosis of hepatocellular carcinoma (hcc) patients.

until now there are two popular procedures during the radical excision of primary liver cancer in our country.one is to give a pringle manoeuvre to control the operative blood loss,the other is using a combination of cusa and tissue-link to control the bleeding while without liver ischemia.according to the recent experimental studies in rats,we know that the ischemia and reperfusion injury may contribute to the metastasis of the tumor.in order to test the actual contribution of ischemia on human,we conduct this prospective clinical trial to compare the two popular procedures' effect on the prognosis of liver cancer patients undergoing radical excision.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of resectable primary liver cancer * the liver function showed:child-pugh a，icg-r15 \< 20% * hbsag (+) * tumor nodes in the liver were singular or multiple and could be radical excision * no preoperative anti-cancer therapy * written informed consent from the patient or legal guardian prior to entering the study exclusion criteria: * pregnancy patients * with extrahepatic tumor or lymphnode metastasis * tumor invasion or thrombosis in portal vein,hepatic vein or inferior vena cava * positive marginal

Keywords: ischemia liver cancer radical excision prognosis
positioning during colonoscopy

Conditions: Colonic Polyps

Summary: colonoscopy is the gold standard investigation in the screening of colorectal neoplasms. the investigators hypothesise that visualisation of the colonic mucosa on extubation may be improved by changing patient position as follows: left lateral position for the right colon, supine for the transverse colon and right lateral position for the left colon(fixed positioning). the investigators aim to validate our hypothesis by performing a randomised control study, comparing mucosal visualisation in patients placed in the 'routine' positions at the discretion of the endoscopist with visualisation in those placed in the above described positions. the hypothesis is that fixed positioning confers an advantage.


Eligibility criteria:
inclusion criteria: * patients requiring colonoscopy exclusion criteria: * polyp surveillance * cancer surveillance * infirmity * pregnancy * colectomy * poor tolerance * failed colonoscopy * poor bowel preparation

Keywords: colonoscopy positioning in colonoscopy quality control
effects of high intensity interval training and strength training in obese

Conditions: Obesity

Summary: obesity is a global health problem since it is associated with many cardiovascular and metabolic diseases, osteoarticular problems and some cancers. that is why it is a priority of the national health policies. exercise is a mainstay in the treatment, but still the most effective method is sought. the resistance exercise and high intensity intervals (hiit) have been shown to positively affect the outcome of the disease, increasing the oxidative capacity of the trained subjects. therefore it is important to look if both together produce greater benefits or otherwise nullify its effects, such as suggested by recent publications in relation to the cellular response to different stimuli such exercise in skeletal muscle. the aim of this study is to evaluate the effectiveness of interventions exercise high intensity intervals, overload and combining them in the oxidative capacity of obese subjects.


Eligibility criteria:
inclusion criteria: * indication of medical supervised exercise * bmi of 25-35kg/m2 * participate in a 10 session rehabilitation program exclusion criteria: * osteomuscular injuries * cardiovascular disease without control * bariatric surgery * high blood pressure without control

Keywords: obesity exercise hiit vo2 kinetics
stress management and resiliency training following acute myocardial infarction

Conditions: Heart Attack; Cardiovascular Diseases

Summary: the goal of this pilot study is to use total body pet/ct imaging to examine the relationships between stress, amygdala activation, and arterial wall inflammation in participants before and after participating in a multi-modal stress reduction program.


Eligibility criteria:
inclusion criteria: * concurrently enrolled in an observational study of patients who have had an acute myocardial infarction * score on pss-10 of 14 or greater during screening * willing and able to access the internet to participate in the online smart program exclusion criteria: * poorly controlled physical or mental health condition that would likely interfere with the ability to participate in smart or ability to undergo pet scan * current daily practice of meditation of 10 minutes or more per day
nerve conduction study for assessment of peripheral neuropathy in rheumatoid arthritis patients on the janus kinase inhibitor baricitinib

Conditions: Rheumatoid Arthritis

Summary: rheumatoid arthritis is a chronic, systemic, autoimmune inflammatory disease that mainly affects the joints and periarticular soft tissues. baricitinib (olumiant®) is an oral, targeted synthetic dmard that inhibits jak1 and jak2, which are implicated in the pathogenesis of rheumatoid arthritis (ra). nerve conduction studies (ncss) are an essential tool in the evaluation of the peripheral nervous system. the sensory nerve action potential (snap) provides information on the sensory nerve axon and its pathway from the distal receptors in the skin to the dorsal root ganglia, while the compound muscle action potential (cmap) is an assessment of the motor nerve fibers from their origins in the anterior horn cell to their termination along muscle fibers.


Eligibility criteria:
inclusion criteria: 1. patients fulfill the 2010 acr/eular classification criteria of ra 2. age above 18 years old. 3. patient cooperative and can answer questions exclusion criteria: 1. other rheumatologic or collagen diseases. 2. age below 18 years and above 65 years. 3. uncooperative patients. 4. patients with other causes of peripheral neuropathy as diabetes mellitus.