Kornimate/medical-research-clean huggingface dataset:
dyslipidemia and risk of cardiovascular disease in diabetic men and women

Conditions: Cardiovascular Diseases; Diabetes Mellitus, Non-insulin Dependent; Heart Diseases; Atherosclerosis; Diabetes Mellitus

Summary: to determine the role of dyslipidemia, markers of endothelial dysfunction genetic susceptibility, and dietary fat intake on the development of cardiovascular disease (cvd) complications in type ii diabetes mellitus.

background: the cardiovascular disease complications of type ii diabetes mellitus are a major public health problem. the research is designed to provide new information about the relation of specific biomarkers, genes, and diet on risk of cvd complications in the high-risk type ii diabetes mellitus population. design narrative: the study assesses biochemical markers of dyslipidemia and endothelial dysfunction, and omega-3 fatty acids in relation to risk of cvd among men and women diagnosed with type 2 diabetes in two large ongoing cohort studies, the nurses health study (nhs) and health professionals follow-up study (hpfs). by 1998, 12,600 confirmed type 2 diabetic cases had already accumulated in the two cohorts. by the year 2002, 5,507 blood samples prospectively collected from persons with previously or newly diagnosed type 2 diabetes will be available for analyses. using this unparalleled resource, the investigators will evaluate (1) the relationship between plasma levels of cell adhesion molecules (i.e. sicam-1, svcam-1, e-selectin), diabetic dyslipidemia, and risk of cvd among diabetics; (2) the association between lp(a) concentrations and risk of cvd among diabetics, independent of high triglycerides and low hdl; (3) the association between long-term intakes of omega-3 fatty acids and cvd risk in diabetes. the main nhs and hpfs grants will provide follow-up and documentation of cvd in addition to covariate information. overall, the large size of these cohorts, the prospective design, the high follow-up rates, and the availability of archived blood specimens provide a unique opportunity to study the relationship between diabetic dyslipidemia and risk of cvd in an extremely cost-efficient and timely manner. in addition, these two cohorts provide an unusual opportunity to compare lipid profiles and endothelial markers of cvd between diabetic men and women.

Eligibility criteria:
no eligibility criteria
study to investigate effect of sildenafil on clitoral engorgement as measured by magnetic resonance imaging (mri) in pre-menopausal women with female sexual arousal disorder

Conditions: Female Sexual Arousal Disorder

Summary: the purpose of this study is to investigate the effect of 100 mg sildenafil on clitoral engorgement in pre-menopausal women, as well as examining the safety and toleration of the drug.


Eligibility criteria:
inclusion criteria: * pre-menopausal women aged 18-45 with a primary diagnosis of female sexual arousal disorder for at least 6 months prior to entering the study. the fsad could have been associated with female orgasmic disorder (fod) and/or superficial or introital dyspareunia. exclusion criteria: * subjects with hypoactive sexual desire disorder. * subjects not using an acceptable mean of contraception for the duration of the study. * subjects who were prescribed and/or taking medication which were contraindicated or cautioned with concomitant intake of sildenafil.
dizziness among first time users of hearing aids

Conditions: Dizziness; Hearing Loss

Summary: the score on the dizziness handicap inventory (short version) before and after hearing aid fitting and usage will be compared


Eligibility criteria:
inclusion criteria: * hebrew speaking * first time users of hearing aids exclusion criteria: * using a wheelchair * neurological disorders * spine of leg surgery in the previous 6 months
pca062 in pcad-positive tumors.

Conditions: Triple Negative Breast Cancer; Head & Neck Cancer; Esophageal Cancer

Summary: a first-in-human sttudy using pca062 in patients with p-cad positive solid tumors.


Eligibility criteria:
inclusion criteria: 1. male or female ≥ 18 years of age 2. documented pcad expressing tumor cells with the exception of hnscc and escc. an archived tumor sample collected within 36 months prior to baseline if available, or a new tumor biopsy sample must be available for molecular pre-screening. 3. consent for a tumor biopsy at screening 4. progressive disease and no effective therapy exists 5. measurable disease as per recist v1.1 criteria 6. ecog performance status of ≤ 2 exclusion criteria: 1. cns metastatic involvement 2. clinically significant cardiac, respiratory, gastrointestinal, renal, hepatic or neurological conditions. 3. a history of serious allergic reactions, which in the opinion of the investigator pose an increased risk of serious infusion reactions. 4. monocular vision or has media opacities or any other condition that precludes monitoring of the retina or the fundus, or has a history of ophthalmology exam with retina or cornea abnormalities 5. previously treated with anti-pcad biologic therapies. 6. received anti-cancer therapies within the following time frames prior to the first dose of study treatment: * conventional cytotoxic chemotherapy: ≤4 weeks * biologic therapy (eg, antibodies), other than adcs: ≤4 weeks * non-cytotoxic small molecule therapeutics: ≤5 t1/2 or ≤2 weeks (whichever is longer) * other investigational agents: ≤4 weeks * radiation therapy (palliative setting is allowed.): ≤4 weeks * major surgery: ≤2 weeks 7. patient has out of range laboratory values defined as: * hematological values: * absolute neutrophil count (anc) \<1.5 x 109/l * hemoglobin (hgb) \<9 g/dl * platelets \<100 x 109/l * hepatic and renal function * total bilirubin \>1.5 x upper limit of normal (uln). for patients with gilbert's syndrome, total bilirubin \>2.5 x uln. * aspartate aminotransferase (ast) or alanine aminotransferase (alt) \>3 x uln for patients without tumor involvement of the liver or \>5 x uln for patients with tumor involvement of the liver. * serum creatinine \>1.5 x uln and/or measured creatinine clearance \< 40 ml/min

Keywords: pca062 triple negative breast cancer head & neck cancer esophageal cancer pcad, pcadherin, solid-tumors
perioperative myocardial and renal injury in patients undergoing hepatic resection

Conditions: Liver Neoplasm; Kidney Injury, Acute; Myocardial Injury After Non-Cardiac Surgery

Summary: liver surgeries are high risk surgeries that might result in injuries in kidneys and heart. this study was planned to investigate the frequency of these injuries as well as the risk factors for their devolopment and its effect on patient outcomes.

hepatic resections are highly invasive major surgical procedures and are associated with higher incidence of end-organ injuries, specifically acute kidney injury (aki) and perioperative myocardial injury (pmi). this study was designed to determine the incidences of aki and pmi, and reveal the risk factors for their development and investigate intraoperative labaratory predictors in patients undergoing hepatic resection. we also planned to evaluate the relationship between the occurrence of end-organ injury and length of hospital and intensive care unit (icu) stay, and 90-day mortality. patients were identified from a prospectively maintained data file that involves the perioperative data of patients undergoing surgery at hepatobiliary-pancreas clinic of başakşehir çam\&sakura city hospital. all consequtive patients within the study period were evaluated for inclusion. 128 patients were eligible for statistical analysis. this sample size was sufficient to determine the incidence of perioperative organ injury with a margin error of 8.4%. green formula revealed that the sample size was sufficient for evaluating 9 variables in a regression model.

Eligibility criteria:
inclusion criteria: * patients who underwent hepatic resection exclusion criteria: * presence of end stage kidney disease * emergency surgery * application of total vascular exclusion * concomitant gastrointestinal resection * duration of surgery less than 100 minutes * non-oncologic procedures

Keywords: hepatic resection acute kidney injury perioperative myocardial injury
evaluating the community drum circle

Conditions: Mental Health Issue; COVID-19

Summary: mental health vulnerability due to stress is increased america due to disproportionate effects of social factors such as racism, poverty, education, and criminal justice sentencing. various meditation and mindfulness approaches have provided evidence of measured reductions in multiple negative dimensions of stress. however, the majority of these studies do not have an adequate representation of persons of african descent(pad) or other marginalized groups and are not designed to be culturally relevant or community based. music has been shown to alleviate multiple symptoms of stress and has been shown to be a preferred and effective support for meditation and mindfulness. however, its role in stress management in pads engaged in meditation or mindfulness is seldom studied. this study aims to evaluate the effects of a community-based music mindfulness program on stress management in pad community members with anxiety and depression during covid19. component 2c. drum circle study: investigators will study the impact of participation in drum circles on anxiety and feelings of connectedness.

the investigators also propose a study to investigate the effects of communal drumming in reducing anxiety and increasing connectedness within drum circle community. investigators hypothesize that these intervention will lead to reductions in scores on stress scales and will provide preliminary data for studies evaluating these types of community programs as an adjunct to the standard of care. individuals who attend periodic (i.e. weekly) drum circles will be recruited to join an 8-week paradigm. drum circle sessions may audio recorded and participants will be informed of this during the consent process. participants may be asked to undergo electroencepholography, functional near infrared spectroscopy, and/or other physiological measures before, during, and after the circles. upon completion of the experiments, participants will be asked to take part in a focus group that will provide valuable feedback on their experience with the mindfulness intervention. focus groups will last 30-minutes to 1 hour and will occur in-person.

Eligibility criteria:
inclusion criteria: * ages 16 and older exclusion criteria: * ages 15 and younger

Keywords: mindfulness meditation music
impact of counselling and visual aid on anxiety in endoscopic patients

Conditions: Chronic Liver Disease; Inflammatory Bowel Diseases

Summary: a single blind randomized controlled trial was conducted to compare the effect of counselling and visual aid on the anxiety levels in patients undergoing endoscopy and to investigate the superiority of visual aid over psychological counselling and preparation for the procedure in an informed patient.

a single blind rct was conducted to assess level of state anxiety between two interventional groups; counselling group and video group. 232 consecutive patients were enrolled from the outpatient department who were scheduled to undergo either a gastroscopy or a colonoscopy (diagnostic or therapeutic). the patients were randomly allocated to one of the two intervention groups (a and b) at the time of endoscopy scheduling. all of the patients received regular instructions regarding gut-preparation at the time of appointment and were also provided with written clear instructions. a gastroenterologist provided information about endoscopy, including the exact preparation instructions and information on the importance of bowel preparation and the adverse effects of the agents used. depression anxiety stress scale-42 was administered at baseline. intervention group a (counselling group) was counselled about the procedure, complications and the post-procedure recovery phase and group b (video group) was also counselled and shown a 5 minutes animated video of the respective procedure in separate room by gastroenterologist. endoscopies were carried out by trained doctors (endoscopists) with a minimum experience of 1000 endoscopic procedures. patients in both the groups were interviewed again after the intervention using depression anxiety stress scale-42.

Eligibility criteria:
inclusion criteria: * both genders (male or female) with a minimum age of 18 years * able to comprehend questions being asked in urdu language * mentally competent at signing the consent form exclusion criteria: * patients who were diagnosed cases of psychiatric illnesses * undergoing emergency endoscopy (whether diagnostic or therapeutic) * end stage renal disease * hearing difficulty * senile dementia * pregnant or diagnosed cases of malignancy * signs of hepatic encephalopathy

Keywords: endoscopy visual aid anxiety counselling
n-acetyl cysteine in the prevention of contrast induced nephropathy in cirrhosis of liver-nephro trial

Conditions: Liver Cirrhoses

Summary: contrast induced nephropathy has an incidence of 7-11 % in patients undergoing contrast imaging for various conditions. the risk associated with the development of cin are still under evaluation. even with patients having normal kidney functions there is a risk of contrast induced nephropathy hence the need for markers which could predict injury. cirrhosis of liver predisposes patient to kidney abnormalities as these patients lower renal reserve and can have various conditions like hepatorenal syndrome, sepsis, atn. contrast imaging is vital for ruling out conditions like hepatocellular carcinoma in patients of cirrhosis of liver. presently there is no study in cirrhosis of liver which studies the effect of n-acetyl cysteine before and after contrast imaging in the prevention of cin. the incidence of cni is cirrhosis is also an avenue which requires more studies and also there is a need for formulation of a score to predict this cin. hence this study is being done to assess the incidence of cni and the role of n-acetyl cysteine in preventing cni.


Eligibility criteria:
inclusion criteria: * age-18-70 years * normal kidney parameters (creatinine below \ 60) * cirrhosis of liver * egfr\>60ml/min exclusion criteria: * chronic kidney disease * h/o anaphylaxis to contrast * prior h/o aki * gfr\<60 ml/min * prior h/o tace/hvpg /contrast echo in the last 4 weeks
the pathogenesis of human senile cataract

Conditions: Cataract

Summary: to study the pathological mechanism of cataract by genomics, transcriptomics, and proteomics.

tissue samples and aqueous humor samples will be collected from each individual patients by cataract surgery. after sample treatment, different techniques will be applied for analysis. and bioinformatics approach is applied for data treatment and analysis.the data of genomics, transcriptomics, and proteomics will be analyzed for study of pathological mechanism of cataract.

Eligibility criteria:
inclusion criteria: * patients with the explicit diagnosis of cataract (including senile cataract, congenital cataract, complicated cataract, metabolic cataract, traumatic cataract, etc.) in the operated eye are willing to undergo cataract surgery. exclusion criteria: * patients whose cataracts need not be operated * patients with any contraindications to cataract surgery * patients are unwilling to undergo cataract surgery
a retrospective pharmacoeconomic study of lung cancer

Conditions: Lung Cancer

Summary: lung cancer is the no. cause of cancer death in taiwan. yet most of lung cancer are diagnosed at late stage, not amenable to surgical resection. with the introduction of new targeted agents, such as egfr tyrosine kinase inhibitors and the identification of egfr mutations, lung cancer management has markedly changed in recent years. however, these new agents are costly and their payment is restricted in certain situations defined national insurance agency. therefore, using databases from national insurance agency might not be able to reflect the exact impact on pharmacoeconomics. in this study, the investigators will analyze the data from a tertiary medical center, where all the costs including insurance reimbursement, co-payment, and payment not covered by insurance. the investigators will also compare with the investigators results with national database to analyze the cost benefit of these new agents on lung cancer.


Eligibility criteria:
inclusion criteria: * lung cancer patients in wanfang hospital exclusion criteria: * non

Keywords: lung cancer pharmacoeconomics new agents
chromoendoscopy to detect early synchronous second primary esophageal carcinoma

Conditions: Squamous Cell Carcinomas of the Head and Neck

Summary: patients with hnscc represent a high-risk group for the development of sescc. thus, esophagogastrofibroscopy should be performed to detect possible synchronous esophageal carcinomas in these patients. although only two patients with synchronous primary carcinomas were found among the patients with newly diagnosed hnscc in this study, esophagoscopy and better some of advanced endoscopic methods should be recommended after detection of hnscc to exclude secondary esophageal carcinoma or dysplasia. staining of the esophagus with lugol's solution is an easy and inexpensive option and can be done in most of gastroenterology offices.

abstract objective: to evaluate the use of flexible esophagoscopy and chromoendoscopy with lugol's solution in the detection of early esophageal carcinomas (second primary carcinomas) in patients with squamous cell carcinoma of the head and neck (hnscc). methods: all patients with newly diagnosed hnscc underwent office-based lugol chromoendoscopy. after flexible esophagoscopy with white light, 3.0% lugol iodine solution was sprayed over the entire esophageal mucosa. areas with less-intense staining (lvls) were evaluated and biopsies taken.

Eligibility criteria:
inclusion criteria: * newly diagnosed patients with head and neck carcinoma * age 18-65 exclusion criteria: * recurrent head and neck carcinomas * previously diagnosed oesophageal cancer

Keywords: head and neck carcinoma chromoendoscopy lugol's solution esophageal carcinoma synchronous tumors deglutition deglutition disorders newly diagnosed hnscc
observation of exhaled voc biomarkers characteristics in admitted women with breast ultrasound bi-rads 4 grade

Conditions: Breast Cancer

Summary: 1. explore vocs indicators that can effectively distinguish between benign and malignant breast diseases. 2. the accuracy of vocs indicators and ultrasound 4a/4b/4c diagnosis will be compared in determining benign and malignant diseases based on pathological gold standards.

inclusion criteria: ultrasound examination within 3 months clearly indicates that breast lesions are bi-rads4a/4b/4c surgical treatment within one week after exhaled voc test informed consent form should be signed exclusion criteria: male women who have been diagnosed as breast cancer by puncture individuals with unclear bi-rads level information by breast ultrasound, including but not limited to bi-rads 4/3-4a/4a-b/4b-c pregnant or lactating women a positive smoking history within one year medical history of malignant tumor, including but not limited to breast cancer (excluding skin basal cell carcinoma) the past history of metabolic diseases, including diabetes, gout, etc respiratory diseases that have been clearly diagnosed in the past, such as asthma and chronic obstructive pulmonary emphysema, are not suitable for participation in the study previously diagnosed digestive system diseases, such as helicobacter pylori positivity and gastric ulcers, are not suitable for participation in the study combination application of drugs related to the treatment of elderly dementia possible cases which researchers believe it is not suitable for this clinical research

Eligibility criteria:
inclusion criteria: * ultrasound examination within 3 months clearly indicates that breast lesions are bi-rads4a/4b/4c * surgical treatment within one week after exhaled voc test * informed consent form should be signed exclusion criteria: * male * women who have been diagnosed as breast cancer by puncture * individuals with unclear bi-rads level information by breast ultrasound, including but not limited to bi-rads 4/3-4a/4a-b/4b-c * pregnant or lactating women * a positive smoking history within one year * medical history of malignant tumor, including but not limited to breast cancer (excluding skin basal cell carcinoma) * the past history of metabolic diseases, including diabetes, gout, etc * respiratory diseases that have been clearly diagnosed in the past, such as asthma and chronic obstructive pulmonary emphysema, are not suitable for participation in the study * previously diagnosed digestive system diseases, such as helicobacter pylori positivity and gastric ulcers, are not suitable for participation in the study * combination application of drugs related to the treatment of elderly dementia * possible cases which researchers believe it is not suitable for this clinical research
an open label study of the safety and efficacy of psilocybin in participants with treatment-resistant depression (p-trd)

Conditions: Treatment Resistant Depression

Summary: the primary objective of this study is to evaluate the efficacy of psilocybin (25 mg) administered under supportive conditions to adult participants with severe trd, in improving depressive symptoms.


Eligibility criteria:
inclusion criteria: * diagnosis of at least moderate major depressive disorder (mdd) exclusion criteria: * comorbidities note for ca site: only veterans are eligible
rate of non-copers to non-surgical acl treatment after 3 months of rehabilitation

Conditions: Anterior Cruciate Ligament Injuries

Summary: the aim is to determine the sensitivity and specificity of a screening tool to identify patients who undergo acl reconstruction (non-copers) after 3 months of standard rehabilitation following an anterior cruciate ligament (acl) injury.

all included patients are referred to municipal rehabilitation to resolve effusion and range of motion deficits before the first screening (baseline screening) is completed. hereafter the patients follow 3 months municipal rehabilitation before the second screening (3 months screening). a physiotherapist performs the screening and at the second screening, this is performed prior to consulting an orthopaedic surgeon.

Eligibility criteria:
inclusion criteria: * unilateral primary acl injury * index injury no older than 6 months exclusion criteria: * multiligament rupture * large cartillage or meniscus injuries * scheduled acl reconstruction within 3 months