Kornimate/medical-research-clean huggingface dataset:
effect of phototherapy incorporated into an exercise program on osteoarthritis of the knee

Conditions: Osteoarthritis of the Knee

Summary: the aim of the proposed study is to analyze the effect of the incorporation of phototherapy into a therapeutic exercise program on pain, functional capacity, range of motion, muscle strength in individuals with osteoarthritis of the knees. the participants will be allocated to different groups through a randomization process using opaque envelopes containing cards stipulating one of the three following groups: group a (exercise protocol); group b (exercise protocol + phototherapy protocol); and group c (exercise protocol + placebo phototherapy protocol). phototherapy will be performed on the knees diagnosed with osteoarthritis.


Eligibility criteria:
inclusion criteria: * diagnosis of osteoarthritis of the knee (unilateral) according to criteria of the american college of rheumatology * age between 40 and 80 years * either gender * knee pain and functional disability for at least six months confirmed by historical medical. exclusion criteria: * dementia * neurological disorder (sensory or motor) * cancer * diabetes * acute adverse health condition * symptoms of osteoarthritis of the hip * cardiopulmonary disease that impedes walking * need for wheelchair or gait-assistance device * and having received steroids through intra-articular injection or orally in the previous six months

Keywords: physical therapy modalities osteoarthritis
investigative mathematical modeling of hospital transmission of hepatitis c

Conditions: Exposure to Hepatitis C Virus

Summary: this project is a prospective observational cohort study to quantify the risk of acquiring hepatitis c virus (hcv) infection for patients and healthcare workers in ain shams university teaching hospital, cairo, egypt through: 1) identifying typical patient trajectories within the hospital; and 2) assessing the ward-specific risk based on the type and number of procedures performed and the prevalence of hcv viremia in patients within each ward.

hepatitis c virus (hcv) is a blood-borne virus and its major route of transmission include blood transfusion, medical injection and procedure, and injecting drug use. in egypt, the origin of the hcv epidemic has been attributed to a mass treatment of schistosomiasis between 1960 and 1984, when intravenous injections with antimony salts were given to 3-5 million people older than 6 years of age. insufficient sterilization of needles and syringes was considered to be responsible for hcv transmission at that time. in order to control the spread of hcv in egypt, the egyptian ministry of health and population established the national committee for the control of viral hepatitis. by 2008, this committee developed a national control strategy for viral hepatitis which has recommended prevention and education campaigns targeting general population and also healthcare workers (hcw). in their occupational environment, hcws are frequently exposed to multiple blood-borne pathogens, including hcv. several risk factors for hcv acquisition among patients and hcws within a hospital ward have been identified, including a high prevalence of hcv infection in the ward, understaffing, workplace characteristic, and human factors such as inexperience or unfamiliar with equipment. however, to the investigators' knowledge, the overall risk of hcv acquisition associated with hospital stay has never been evaluated in egypt. also, control measures to reduce the risk of hcv transmission in hospital settings, based on a global assessment of healthcare provider logistics and performance, have never been proposed in egypt. in this project, the investigators assume that hcv will be transmitted to both hospital staff and patients. given the slow dynamics of the hcv epidemic, the investigators further hypothesize that, in the short term, the prevalence of hcv viremia among patients will be constant. therefore, the investigators are led to conclude that hcv transmission risk may be inferred from a detailed description of individual trajectories of patients or staff within the hospital.

Eligibility criteria:
inclusion criteria for patients: * aged 21 years or older * staying in the hospital more than 24 hours * provided a written informed consent to participate inclusion criteria for healthcare workers: * aged 21 or older * provided a written informed consent to participate
treatment of elderly subjects with psychosis and behavioral disturbances associated with dementia of the alzheimer's type

Conditions: Psychosis and Behavioral Disturbances Associated With Dementia of the Alzheimer's Type

Summary: this is a 10-week study with bifeprunox and placebo in elderly subjects with psychosis and behavioral disturbances associated with dementia of the alzheimer's type.


Eligibility criteria:
inclusion criteria: * diagnosis of dementia of the alzheimer's type exclusion criteria: * history of seizure disorder * clinically significant electrocardiogram (ecg) * clinical or radiological evidence of stroke, vascular dementia or dementia due to substance abuse, or head trauma
observational data collection of surgical outcomes in the treatment of vaginal prolapse with ams products

Conditions: Vaginal Prolapse

Summary: this registry was observational (only collected information typically noted by the surgeon when their patients were routinely seen); there was no change to the care the patient received as a result of being part of the registry). data collection focused on the surgical outcomes of ams prolapse products.

the prolapse registry was an observational study of patients who were implanted with ams devices for the surgical repair of female pelvic prolapse. the registry followed patients post-operatively for up to 2 years and collected demographic, clinical, surgical, safety, and patient outcomes data. the registry was a web-based system in which surgeons entered patient information with regard to their prolapse surgery. all information entered was de-identified (no names, no date of birth, no date of surgery, etc).

Eligibility criteria:
inclusion criteria: * female at least 21 years old * has pelvic organ prolapse requiring surgical repair * receives at least one of the ams prolapse repair devices in the treatment of their pelvic organ prolapse exclusion criteria: * is contraindicated for an ams prolapse repair per the product's instruction for use.

Keywords: vaginal prolapse cystocele rectocele enterocele apical prolapse vaginal vault prolapse
assessing the feasibility of the patient-reported outcomes based model for community care of patients with axial spondyloarthritis via a type 1 pilot hybrid effectiveness-implementation trial using the re-aim framework

Conditions: Axial Spondyloarthritis

Summary: the goal of this clinical trial is to facilitate the implementation of proms-based care for patients with axial spondyloarthritis. the main questions it aims to answer are: * what are the barriers, facilitators and strategies to implement proms-based care? * can the promise algorithm successfully review and postpone appointments of eligible patients? * how feasible is proms-based care in patients with axial spondyloarthritis? researchers will implement proms-based care and see if proms-based care is feasible and understand patient's opinions on proms-based care implemented. participants will: * be randomized to either receive intervention (prom-based care) or control (usual care). randomisation means assigning you to one of two groups by chance, like tossing a coin or rolling dice. * that receive proms-based care, will be sent proms questionnaires that ask them about their health conditions via sms at a regular interval of 4 months. * have their appointments postponed by 4 months, if the promise algorithm with specific thresholds (with overview from the rheumatology care team) assess their condition as stable through their blood test results and proms questionnaire. * have a cap of 12 months between physician visits.


Eligibility criteria:
inclusion criteria: * diagnosed with axial spondyloarthritis according to the 2009 asas classification criteria of axspa * has been receiving care in singapore general hospital for at least 6 months * aged 21 years and above exclusion criteria: * bath ankylosing spondylitis disease activity index score of \>4
the effect of srs on hemiplegia in stroke survivors

Conditions: Stroke

Summary: strokes are one of the leading causes of long term disability and death in the united states. a stroke occurs when the blood supply to the brain is blocked, damaging parts of the brain. many stroke survivors have difficulty completing dexterous hand movements and manipulating objects due brain damage in the sensorimotor cortex. damage to these areas can cause decreased motor movements and tactile sensation on the affected side. research shows that tactile sensation is necessary for maintaining grip, grading grip forces and decreasing object slippage. therefore, it is important to address tactile sensation with motor performance during stroke rehabilitation to improve performance outcomes among stroke survivors.

a novel intervention that has shown immediate improvements in tactile sensation is called stochastic resonance stimulation. srs is a phenomenon where cutaneous sensation can be enhanced with the presence of tactile noise in a nonlinear system. this theory suggests that the application of an imperceptible vibrotactile stimulation increases the synchronization of afferent neurons firing to the somatosensory cortex, ultimately increasing the excitability of mechanoreceptors in the skin suggesting that afferent signals from the periphery to the somatosensory cortex influence motor movements. however, more research is needed to document the changes in motor performance with the use of srs and it is unclear how srs stimulation changes different measurable sensory processing differences

Eligibility criteria:
inclusion criteria: * stroke survivors over the age of 18 * at least six months post stroke * ability to provide verbal informed consent and written informed consent * score of at least 56 on the fugl meyer assessment total motor scores * able to detect at least 6.65 (300 grams) on the semmes weinstein monofilament on both the pads of the thumb and index finger * able to complete the nine hole peg test * able to reliably express pain, discomfort, or fear * speak english exclusion criteria: * history of upper extremity orthopedic conditions, such as arthritis, surgery, etc. * aphasia caused by stroke * does not have arom * currently have muscle contractures in upper extremity * participating in other research studies * patients with electrically operated implanted device (e.g. cardiac pacemaker/defibrillator, drug delivery pump, and neurostimulator) * history of smi (e.g. schizophrenia, schizoaffective disorder) * history of neurodegenerative disability (e.g. multiple sclerosis, parkinson's disease) * have received botulinum injections in the paretic limb within the past three months

Keywords: srs- stochastic resonance stimulation sr- stochastic resonance
a study of the effect of altitude on mircera (methoxy polyethylene glycol-epoetin beta) dose requirements in participants with chronic renal anemia in pre-dialysis or dialysis

Conditions: Anemia, Kidney Disease, Chronic

Summary: this comparative, open-label, multicenter, parallel-group study evaluated the effect of altitude on the dose requirements of mircera (methoxy polyethylene glycol-epoetin beta) to achieve a target hemoglobin concentration of 11-12 grams per deciliter (g/dl) in participants with chronic renal anemia in pre-dialysis and dialysis. four groups of participants, at sea level (below 50 meters) or an altitude above 1800 meters, and pre-dialysis or dialysis, received 50-250 micrograms (mcg) mircera subcutaneously (sc), according to the local prescribing label.


Eligibility criteria:
inclusion criteria: * adult participants, \>/= 18 years of age * chronic kidney disease stage iii-iv or v * probable start of dialysis within 18 months (pre-dialysis group) * hemodialysis or peritoneal dialysis in a stable regimen for at least 3 months (dialysis group) * adequate iron status * females of childbearing potential must agree to use two effective methods of contraception during the study and for at least 2 months following the last dose of study drug exclusion criteria: * failing renal allograft in place * acute or chronic bleeding within 8 weeks prior to screening * transfusion of red blood cells within 8 weeks prior to screening * poorly controlled hypertension, defined as hypertension that needs hospitalization to obtain control * history of seizures, hemoglobinopathies and/or severe liver disease * active malignant disease, except for non-melanoma skin cancer * immunosuppressive therapy in the 12 weeks prior to screening * treatment with any other investigational agent or participation in a clinical trial within 28 days prior to enrolment * known hypersensitivity to mircera (methoxy polyethylene glycol-epoetin beta) or any of its excipients * pregnant or lactating women
berberis vulgaris consumption and blood pressure

Conditions: Blood Pressure; Cardiovascular Risk Factor; Lipid Profile

Summary: the aim of this study is to investigate the effect of barberry consumption on systolic and diastolic blood pressure, serum lipids, and inflammatory status. the study will involve cases having elevated bp (129/ \< 85) and known hypertensive patients on medical treatment. seventy people will be randomized into two groups, including intervention (barberry) or placebo groups. before and after of 8 week intervention, 24-hour ambulatory blood pressure monitoring will be done and fasting venous blood sample will be taken to measure plasma lipids. in addition, 24-hour urine will be collected to measure its sodium content and estimate sodium intake.


Eligibility criteria:
inclusion criteria: * willingness to participate in the study * age between 20-65 years * having elevated bp (129/ \< 85) and known hypertensive patients on medical treatment * at least one other classical cardiovascular disease risk factors, including hyperlipidemia or diabetes mellitus exclusion criteria: * unwillingness to continue participation * bmi\> 30 * patients on nitrates * high doses of statins consumption (atorvastatin\>40 mg/day or rosuvastatin\>20 mg/day) * consumption of vitamins or minerals supplements during past month * chronic kidney disease stage 4 or 5

Keywords: barberry berberis vulgaris blood pressure lipids inflammation
effect of core exercise on adl in hemodialysis

Conditions: Hemodialysis

Summary: finding the effect of core stability exercises with breathing exercises on activities of daily living (adls), fatigue level and balance in maintenance hemodialysis patients.

sixty patients will be randomly assigned into two equal groups, the experimental (ex) group and the control group (con). the participants' age will be 50-65 years and undergo hemodialysis. the ex-group will attend three sessions/week of core stability exercise training (cse) combined with deep breathing (25:30-min) for 8 weeks, the con will attend 3 sessions/week of deep breathing (15-min) for 8 weeks. all the patients received only routine hemodialysis department care.

Eligibility criteria:
inclusion criteria: * adults ranging from 55- 70 years old of both genders. * diagnosed as maintenance hemodialysis for at least 6 months or more. * free from mental illness, neuromuscular disorders, and serious lung problems and able to implement the interventional exercise. exclusion criteria: * obesity (bmi ≥ 30 kg/m2) * orthopeadics or neurological problems that interferes with training. * history of pulmonary problems (copd, pneumonia) * history of myocardial infarction and/or cardiothoracic surgery * unstable medical status * dementia that interferes with the ability to follow instructions. * history chronic fatigue syndrome (cfs).

Keywords: core exercise adl balance hemodialysis
prospective study to determine the factors influencing infant colic

Conditions: Infant Colic

Summary: randomized study to determine the effect of a commercialized combination of 2 probiotic strains (bifidobacterium longum and pediococcus pentosaceus) and the impact of feeding type in babies diagnosed with colic under roma iv criteria when administered for 21 days.

randomized, single-blind, interventional study with two parallel groups to determine the effect of two different commercialized probiotic products (lactobacillus reuteri or a combination of two different strains (bifidobacterium longum and pediococcus pentosaceus)) and the impact of feeding type in babies diagnosed with colic under roma iv criteria. infants meeting selection criteria are randomized 1:1 and stratified according to the type of feeding (breastfed or formula). probiotics are administered once a day (5 drops) for 21 days. parents must document clinical parameters during this 21 days. this parameters include colic-related symptoms, other functional gastrointestinal disorders symptoms, parental anxiety and adverse events. moreoever, stool samples are collected to determine intestinal microbiota and calprotectin levels.

Eligibility criteria:
inclusion criteria: * healthy infants from 2 to 12 weeks of age * infants diagnosed with infant colic following roma iv criteria for clinical research * gestational age greater or equal to 37 weeks * birth weight greater than 2100 g * exclusively breastfed or formula fed with a maximum of one daily intake of breast milk. exclusion criteria: * infants that are fed with solid food. * infants whose parents can not appropriately follow the requirements of the study. * antibiotics or probiotics administration to the infant (including infant formula with probiotics) 2 weeks prior the inclusion in the study. * breastfed infants whose mothers have taken antibiotics and/or probiotics 2 weeks prior the inclusion in the study. * infants fed extensively hydrolyzed infant formula * specific medication use for the treatment of functional digestive disorder: antacids (ibp type or h2 blockers), laxative polyethylene glycol (8peg), lactulose, magnesia), lactase or simeticone. * infants going through therapies related with acupuncture, homeopathy, medicinal herbs, or taking anti-inflammatory or antispasmodic drugs.

Keywords: infant colic, probiotic
renal cell carcinoma metastases to pancreas

Conditions: Surgery

Summary: patients' outcome was studied after surgery for renal cell carcinoma. the primary outcome was overall survival and desease free survival. secondary outcame was complications to surgery.

study design. the study is a single-center study and includes all patients from the age of 18 who underwent a pancreatic resection due to metastasis from rcc from 1. january 2011 to 31. december 2021. patients, who underwent additional pancreatic resection after surgery for metastatic rcc, were excluded. the follow-up period ended 31. december 2022. data collection. data are collected from a prospectively maintained database of pancreatic operations, from the electronic hospital record systems orbit and epic, the danish national pathology data registry, and from the national register of death. all danish nationals have a unique central person registration number that enables searching of health data. outcome. extracted data included patient demographics, date, and site of nephrectomy, leibovich score, type of pancreatic resection, 30-days postoperative complications according to the clavien-dindo classification system, procedure specific complications (pancreatic fistula or biliary leak) according to the international study group on pancreatic surgery (isgps), pathology of resected pancreatic specimen. postoperative data included time and site of disease recurrence after pancreatic resection, disease free survival (ds) and overall survival (os). the postoperative follow-up included standard imaging surveillance with computed tomography scan (ct) of the chest and abdomen at specific intervals depending on the leibovich score. statistics. clinicopathologic characteristics were summarized using descriptive statistics. data are presented as median and range if not otherwise stated. categorial data are presented as numbers or percentage and were analysed with fisher's exact test. the kaplan-meier method was used to estimate survival. post-pancreatectomy survival was defined as date of pancreatic resection to death. post-pancreatectomy disease free survival was defined as the median time from the date of pancreatic resection to the date of detection of recurrence of disease, expressed in months. statistical analysis was performed using graphpad version 9.5.1 la holla, ca. the study was reported according to the strocss guidelines. ethics the study is a register study and was conducted in accordance with the principles stated in the declaration of helsinki. no approval was required according to the danish national health board. the use of register data followed the general data protection regulation of the european union and was approved by the danish data protection agency (rh -2015-07, nr. 03616) and patients' consent.

Eligibility criteria:
inclusion criteria: participants, who underwent pancreatic resection for metastatic renal cell carcinoma - exclusion criteria: participants, who underwent additional pancreatic resection after surgery for metastatic renal cell carcinoma. -

Keywords: pancreatic resection, pancreatic metastase
the effect and frequency of helicobacter pylori infection in primary immune thrombocytopenic patients

Conditions: Effects Toxics

Summary: immune thrombocytopenia (itp) is an autoimmune disorder characterized by low platelet count (i.e less than 100.000) . in itp, platelet surface membrane proteins become antigenic for unknown reasons , leading to stimulation of the immune system , autoantibody production, and platelet destruction in recent years ,the list of etiologies of itp has been steadily increasing, so the term "idiopathic" is becoming obsolete, increasingly replaced by "immune"tp . treatment of itp may be conceptually divided into rescue therapy and maintenance therapy . the terminology of corticosteroid-dependence means the need for ongoing or repeated doses administration of corticosteroids for at least 2 months to maintain a platelet count at or above 30 _ 109/l and/or to avoid bleeding. so, patients with corticosteroid dependence are considered non responders

• immune thrombocytopenia (itp) is an autoimmune disorder characterized by low platelet count (i.e less than 100.000) . in itp, platelet surface membrane proteins become antigenic for unknown reasons , leading to stimulation of the immune system , autoantibody production, and platelet destruction in recent years ,the list of etiologies of itp has been steadily increasing, so the term "idiopathic" is becoming obsolete, increasingly replaced by "immune"tp. treatment of itp may be conceptually divided into rescue therapy and maintenance therapy. the terminology of corticosteroid-dependence means the need for ongoing or repeated doses administration of corticosteroids for at least 2 months to maintain a platelet count at or above 30 _ 109/l and/or to avoid bleeding. so, patients with corticosteroid dependence are considered non responders the recent entry of helicobacter pylori to the growing list of etiologies of itp has stirred much interest. . the relationship between h pylori infection and immune thrombocytopenia (itp) is less clear . however, among patients with h.pylori-associated itp, a significant percentage achieve lasting remission after eradication of h.pylori . h.pylori can be readily detected by non invasive methods, the c-urea breath test and antigen detection in stools are considered to be the most accurate, with both sensitivity and specificity in the range of 90% to 95% .

Eligibility criteria:
inclusion criteria: 1.patients diagnosed itp and failed on steroid therapy. exclusion criteria: 1. patients with systemic lupus erythromatous 2. drug administration 3. hepatitis c infection

Keywords: frequency