Kornimate/medical-research-clean huggingface dataset:
dmek and cataract surgery: comparison of sequential versus combined procedure

Conditions: Cataract; Corneal Graft

Summary: the aim of this study is to describe the outcomes of phaco-dmek (descemet membrane endothelial keratoplasty ) according to a sequential versus a combined procedure

the study included patients who underwent dmek combined or not with cataract surgery between january 2014 and march 2016. were excluded patients with other ocular comorbidity, and those who had graft after a first graft failure. the main outcome was bvca measured at one year. the post-operative follow up was down at d7, m1, m3, m6, and m12. secondary outcomes were; the mean time to visual recovery and influence of the delay between cataract removal and dmek.

Eligibility criteria:
inclusion criteria: * patients who underwent dmek combined or not with cataract surgery exclusion criteria: * patients with other ocular comorbidity, and those who had graft after a first graft failure
maladaptive adipose tissue activity in cancer

Conditions: Cancer Nos

Summary: the purpose of this pilot research is to study brown adipose tissue, a type of fat that increases metabolism (burns energy) during exposure to cold, and how it may contribute to the weight loss observed in cancer.

the purpose of this research is to study brown adipose tissue, a type of fat that increases metabolism (burns energy) during exposure to cold, and how it may contribute to the weight loss observed in cancer. many patients affected by cancer lose weight, despite normal or increased nutrition. it may progress to the condition called "cancer-associated cachexia." cancer associated cachexia is defined by an ongoing loss of skeletal muscle mass with or without the loss of fat mass, and may negatively affect quality of life and the ability to undergo cancer treatments. metabolism is the breakdown of food by the body into the energy that your body needs.

Eligibility criteria:
inclusion criteria: * ≥ 40 years of age * have active cancer diagnosis. * have had a pet/ct scan within the past 12 months at time of enrollment. * ability to understand and the willingness to sign a written informed consent document exclusion criteria: * current use of beta-blockers * women who are pregnant or unsure of their pregnancy status * women who are breastfeeding * suffers from severe claustrophobia * diagnosed with a serious psychiatric condition which could impede the judgement of the investigators, and/or the successful conduct of the recording. * in remission stage for cancer diagnosis
accuracy of host-derived biomarkers in diagnosing symptomatic and asymptomatic apical periodontitis

Conditions: Biomarkers

Summary: apical lesions usually present clinically as a chronic infection, remaining as asymptomatic apical periodontitis(aap). because the balance among inflammation and bacteria is a dynamic process, aap may undergo an acute exacerbation and become symptomatic, presenting as symptomatic apical periodontitis or acute abscess, or it may evolve from the acute to the chronic stage. identification of specific biomarker could help in establishing more accurate diagnosis. biological marker serves as a parameter that is indicative of underlying physiology and health of the tissue. it is measurable as well as quantifiable. the aim of this study: to assess the level of potential biomarkers in asymptomatic and symptomatic apical periodontitis, and to determine the prediction potential of the same biomarkers for the outcome of endodontic treatment after 1year recall...

participants will be selected from patients attending the restorative and aesthetic department in the college of dentistry university of baghdad. consent form will be assigned with all participants prior to the study to take their agreement for participation. also case sheet including all diagnostic procedures will be prepared and used with all cases. the involved tooth should not have more than 3 surfaces affected with caries including mesioocclusal(m0), distoocclusal(do) or mesio occlusodistal( mod). cone beam computed tomography (cbct) will be taken for the accused teeth. gingival crevicular fluid(gcf) samples will be collected from the gingival sulcus of the test and healthy teeth within the same participant. the gcf samples will be centrifuged at 400-500 g for 4-5 min and concentrations of matrix metaloproteinases(mmp8), tissue inhibitor(timp1),receptor activator of nuclear factor kappa-b(rank), rank ligand(rankl) andosteoprotegerin( opg) will be determined using elisa test.

Eligibility criteria:
inclusion criteria: * systematically healthy individuals with healthy periodontal status which can be detected by periodontal probing depth (ppd) and bleeding on probing (bop). * both sexes and ages between 25-45 years old will be targeted. * patients with one or more sap or aap teeth will be included within this study. * the involved tooth or teeth have to be one or both of the maxillary premolars either in one or both sides. * selected sap and aap has to be without periodontal diseases. exclusion criteria: systematically unhealthy individuals or those who consumed any treatment that may affect periodontal condition. * consumption of antibiotics within 3-months prior to the study first examination. * periodontitis. * smoker. * pregnancy and lactation
pediatric distal radius us study

Conditions: Distal Radius Fractures

Summary: the purpose of the study is to evaluate the sensitivity and specificity of using a diagnostic musculoskeletal ultrasound in pediatric distal radius fractures in an outpatient setting. ultrasound reliability and accuracy will be tested. the result of the diagnostic ultrasound will be compared to x-ray diagnosis under routine conditions in the investigator's injury and fracture treatment evening clinic. data will be collected and recorded during the duration of the 12 week study. through the literature review and experience with ultrasound, the investigators anticipate that diagnostic ultrasound will provide very high sensitivity and specificity in diagnosing distal radius fractures in children.


Eligibility criteria:
inclusion criteria: * pediatric patient with a wrist injury. exclusion criteria: * gross deformity of the injured body part, suspected open fractures and the need for emergent surgery

Keywords: diagnostic ultrasound
tumor tissue analysis in patients receiving imatinib mesylate for malignant glioma

Conditions: Brain and Central Nervous System Tumors

Summary: rationale: collecting samples of tumor tissue and blood from patients with cancer to study in the laboratory may help doctors learn how patients respond to treatment. purpose: this clinical trial is looking at tumor tissue samples from patients receiving imatinib mesylate for malignant glioma to see how much imatinib mesylate is found in the tumor tissue.

objectives: primary * determine the efficacy, of imatinib mesylate, in terms of achieving a therapeutic tumor:plasma concentration ratio, in patients with primary malignant glioma. secondary * correlate tumor grade (low vs high) and/or tumor enhancement on mri with tumor concentration of this drug in these patients., outline: patients receive oral imatinib mesylate once daily for 7-12 days. patients then undergo surgical resection. blood and tissue samples are collected at the time of surgery and analyzed for imatinib mesylate concentration. after completion of study treatment, patients are followed for 7 days. projected accrual: a total of 33 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * histologically confirmed malignant glioma of 1 of the following subtypes: * low-grade glioma * anaplastic astrocytoma * anaplastic oligodendroglioma * glioblastoma multiforme * unifocal disease that is progressive or recurrent after prior radiotherapy and/or chemotherapy * scheduled to undergo surgical resection * able to undergo maximal surgical resection of tumor mass patient characteristics: * karnofsky performance status 70-100% * mini mental status exam ≥ 15 * absolute neutrophil count ≥ 1,500/mm³ * platelet count ≥ 100,000/mm³ * creatinine ≥ 1.7 mg/dl * bun ≤ 2 times upper limit of normal (uln) * transaminases ≤ 4 times uln * not pregnant or nursing * fertile patients must use effective contraception during and for ≥ 1 month after completion of study treatment * no other medical illness that would preclude study treatment, including any of the following: * serious infection * uncontrolled hypertension * unstable angina pectoris * uncontrolled cardiac dysrhythmia prior concurrent therapy: * see disease characteristics * recovered from all prior therapy * at least 4 weeks since prior investigational drugs * no more than 1 prior chemotherapy regimen * no concurrent chemotherapy, biologic therapy, or radiotherapy * no concurrent medications that may interact with imatinib mesylate or interfere with hepatic cytochrome p450 system

Keywords: adult anaplastic oligodendroglioma adult oligodendroglioma adult anaplastic astrocytoma adult giant cell glioblastoma adult gliosarcoma recurrent adult brain tumor adult brain stem glioma adult mixed glioma adult glioblastoma adult pilocytic astrocytoma adult diffuse astrocytoma adult anaplastic ependymoma adult ependymoma adult myxopapillary ependymoma adult subependymoma adult pineal gland astrocytoma adult subependymal giant cell astrocytoma
investigation of the effect of erector spinae plane block on systemic immuno-inflammatory index

Conditions: Erector Spinae Plane Block; Systemic Immune-inflammatory Index; Breast Cancer

Summary: erector spinae plane block (espb) is a novel interfascial block technique first described by forero in 2016. it has been reported to be effective in various clinical indications. in espb, local anesthetic is injected between the deep fascia of the erector spinae muscle and the transverse process of the vertebra, allowing cephalocaudal spread along the erector spinae muscle. the goal of the injection is to provide sensory blockade by affecting the anterior rami of the spinal nerves in the region. espb has been used during breast and axillary lymph node surgeries to manage postoperative pain. in addition to tumor cells, immune and inflammatory cells such as neutrophils, platelets, and lymphocytes contribute to the dissemination and invasion of tumor cells into the peripheral circulation. noninvasive biomarkers such as serum inflammatory markers are increasingly valued for their simplicity and predictive potential. platelets have been shown to facilitate epithelial-mesenchymal transition of tumor cells; neutrophils support tumor adhesion via growth factors such as vegf and proteases; lymphocytes play a role in modulating the host immune response to malignancy. the systemic immune-inflammatory index (sii), calculated as (platelet count × neutrophil count) / lymphocyte count, is a relatively new composite marker that reflects immune and inflammatory responses. it has been evaluated as a prognostic biomarker in several cancer-related studies. postoperative pain and surgical stress activate systemic inflammatory responses. espb is performed as part of postoperative analgesia in patients undergoing breast cancer surgery under general anesthesia, based on voluntary participation. the aim of this study is to evaluate the effect of espb on postoperative sii levels in comparison to other analgesia modalities.


Eligibility criteria:
inclusion criteria: * female patients aged 18-75 years * asa (american society of anesthesiologists) physical status i-ii-iii * undergoing unilateral breast cancer surgery under general anesthesia * volunteered to participate in the study and signed informed consent exclusion criteria: * allergy or contraindication to local anesthetics * coagulopathy or on anticoagulant therapy * infection at the injection site * history of chronic pain or opioid use * neurological or psychiatric disorders affecting pain perception * refusal to receive regional anesthesia

Keywords: breast cancer systemic immune inflammatory index (sii) erector spinae plane block (espb) stress response
left atrial appendage (laa) occluders after catheter ablation of atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the primary objective of this study is to assess combined end point (all stroke, systemic embolism, cardiovascular death) between two groups.


Eligibility criteria:
inclusion criteria: * patient has paroxysmal, persistent or permanent non-valvular atrial fibrillation (af) * eligible for long term warfarin * chads score \>= 1 (congestive heart failure \[chf\], history of high blood pressure, 75 years of age or older, diabetes, prior stroke or transient ischemic attack \[tia\]) exclusion criteria: * contraindicated for warfarin * contraindicated for aspirin or clopidogrel (plavix) * chf class 4 * implanted mechanical valve * atrial septal or patent foramen ovale (pfo) device * platelets \< 100,000 or hemoglobin \< 10 * left ventricular ejection fraction (lvef) \< 30%

Keywords: catheter ablation
kiva anti-bullying program in chile: evaluation of effectiveness with and without the digital game component

Conditions: Bullying

Summary: bullying is a major problem worldwide and, with no exception, in chile. bullying is defined as a systematic aggressive behavior against a victim who cannot defend himself or herself. victims suffer many consequences such as social isolation, psychological maladjustment, and self-injury behavior. additionally, bullies have a higher risk for conduct problems and substance use disorders. these problems appear to last in time, affecting mental health even years later since the experience of bullying. there are few studies in chile aiming to determine the prevalence of bullying. in one of such studies, 47% of the students reported having been bullied during the last month before the application of the questionnaire. even though there are many initiatives and guidelines in chile supported by the government to help schools in order to deal with bullying, there is no any cluster randomized controlled trial (rct) aiming to assess the effectiveness of an anti-bullying program. kiva anti-bullying prevention program contains universal and indicated actions. main universal actions for 5 to 6 graders consist of 10 two-hours lessons given during a year and an online game, which have the aim to raise awareness of the role of the group in bullying, increase empathy and promote strategies to support victims. indicated actions consist of a set of discussion groups with the victims and with the bullies with proper follow-up. the aims of this study are: 1) to develop a culturally appropriate version of the kiva material, and 2) to test its effectiveness of kiva program with and without the online game, to reduce bullying behavior among low-income primary schools in santiago using a cluster rct design with three arms: i) kiva full program group, ii) kiva without online game program group, and iii) control group.


Eligibility criteria:
inclusion criteria for schools: * primary education * co-educational * high vulnerability (measured by the chilean index ivesinae \>75%) * location: santiago, chile. * exact two classes per level (5th grade and 6th grade), during the intervention.

Keywords: bullying kiva program primary school students
the effect of intradialytic exercise on the physical function of people undergoing hemodialysis

Conditions: End Stage Renal Failure on Dialysis; Frail Elderly Syndrome

Summary: the investigators intend to recruit 50 patients into an intradialytic exercise study that will measure the impact of resistance bands exercises under the guidance of an exercise physiologist on the physical function of hemodialysis patients.

the primary objective of this study will be to test the feasibility and efficacy of a 3 month exercise physiologist consultation program. specifically, the investigator's aims will be to: 1. test the feasibility of a 3-month exercise physiologist led program 2. measure the effect of an exercise physiologist collaboration and intradialytic exercise on the physical function of hd patients using the 30 second sts test, handgrip strength test \[required for frailty scale\], 8-foot tug test and patient physical activity based off of the low physical activity questionnaire.

Eligibility criteria:
inclusion criteria: * age 18 years or greater * ability to understand and communicate english * diagnosis of esrd and currently undergoing in-center hemodialysis * on hd for longer than 6 weeks * approved by the satellite milpitas medical director and/or referring physician exclusion criteria: * previous major amputations * inability to independently ambulate * known to be pregnant

Keywords: intra-dialytic exercise end stage renal disease hemodialysis therabands exercise physiologist
comparison of modified-otago and tai chi exercises in patients with stroke

Conditions: Stroke

Summary: the study aims to determine the comparative effects of modified-otago and tai chi exercises on balance and motor function in patients with stroke.

this randomized clinical trial will be conducted at the physiotherapy and chiropractor centre, lahore. data will be collected within seven months after the approval of synopsis. a total of 64 patients will be recruited through convenience sampling technique after inclusion and exclusion criteria. after the baseline assessment, randomizations will be performed through the lottery method. group a will receive modified otago exercises for 60 minutes, 3 times per week for 12 weeks, and group b will receive tai chi qigong exercises for 60 minutes, 3 times per week for 12 weeks. to assess the balance and motor function, the berg balance scale (bbs) and motor assessment scale will be used, respectively. the data will be analyzed by using the spss (statistical package for social sciences) 23 version.

Eligibility criteria:
inclusion criteria: 1. clinically diagnosed stroke patients with ischemic type. 2. post-stroke ≥ 3 months. 3. survivors of both hemorrhagic and ischemic stroke. 4. subjects should have stable conditions after the stroke incidence. 5. community-dwelling survivors of stroke who were aged ≥40 years. 6. both genders can participate in the study. 7. mini-mental state exam score equal to or greater than 24. 8. modified rankin scale score of three or less. 9. berg balance scale score is between 41 and 52. 10. muscle strength grade should be of grade 4 and above. exclusion criteria: 1. subjects with diagnosed peripheral neuropathy. 2. the subject is unable to perform tai chi exercises. 3. no history of other neurological and musculoskeletal conditions. 4. subjects with diagnosed vestibular disease. 5. subjects have cardiac abnormalities. 6. contracture, fracture, or pain in the musculoskeletal system. 7. subjects who have undergone strength and balance training in the past 3 months. 8. subject taking medications that increase the incidence of falls. 9. subjects have been diagnosed with malignancy of any type.

Keywords: modified-otago exercises tai-chi exercises stroke randomized clinical trial
analysis of paediatric treatments with multifiltratepro

Conditions: Renal Failure; CVVHD

Summary: this clinical study evaluates the performance of the multifiltratepro in pediatric mode for continuous venovenous hemodiafiltration (cvvhd) in children. its primary aim is to assess the efficacy of the multifiltratepro in paediatric mode, specifically in achieving at least 80% of the prescribed effluent dose within 72 hours. additionally, the study focuses on the safety of this mode in a paediatric setting, closely monitoring for clinical adverse events, hemodynamic instability, and electrolyte imbalances. paediatric patients with body weights between 8kg and 40kg will be treated with the multifiltratepro for a period of up to 10 days, with the treatment duration and approach being tailored to the severity of each patient's condition.


Eligibility criteria:
inclusion criteria: general: * paediatric patients: * informed consent signed and dated by legal representative and investigator/ authorized physician. * the minors have received the information referred to in article 63(2) mdr in a way adapted to their age and mental maturity and from investigators or members of the investigating team who are trained or experienced in working with children. * the explicit wish of a minor who is capable of forming an opinion and assessing the information referred to in article 63(2) mdr to refuse participation in, or to withdraw from, the clinical investigation at any time, is respected by the investigator. study-specific: * estimated life expectancy greater than 3 days * children under 18 years * body weight ≥8kg and \<40kg * patients with clinical indication for cvvhd exclusion criteria: general: * any conditions which could interfere with the patient's ability to comply with the study * patient or legal representative is not able to give informed consent according to european medical device regulation and corresponding national regulations * in case of female patients: pregnancy or lactation period * participation in an interventional clinical study during the preceding 30 days * previous participation in the same study study-specific: * hypersensitivity to heparin or known history of heparin induced thrombocytopenia (hit type ii) * uncontrolled bleeding and coagulation disorders * decision to limit therapeutic interventions * inability to establish the required vascular access

Keywords: acute kidney injury renal replacement therapy haemodiafiltration contintious kidney replacement therapy paediatric
parecoxib vs. dexketoprofen for the management of pain after cesarean section.

Conditions: Caesarean Section; Pain

Summary: although it is known that parecoxib and dexketoprofen are commonly used in successful post-operative pain relief, there are very few studies that compare these two agents in their individual applications and/or combined with neuraxial analgesia with opioids and even less in post-cesarean section pain, as well as the evaluation of the side effects and their impact on the patient's functionality. for this reason, in order to approach this answer, we sought to perform this study in patients undergoing elective or emergency cesarean section in our institution, who meet the inclusion criteria, using the visual analog pain scale at 12 hrs and 24 hrs post surgery and evaluating the aforementioned side effects, comparing in one arm of the study parecoxib + acetaminophen vs dexketoprofen + acetaminophen in the other arm, randomizing the patients in both groups using a double-blind configuration.


Eligibility criteria:
inclusion criteria: * pregnancy 32w or more. * emergency or elective caesarean section. exclusion criteria: * allergy to parecoxib. * allergy to dexketoprofen. * allergy to acetaminophen. * general anesthesia.

Keywords: caesarean section pain parecoxib dexketoprofen