exercise prescription in patients with bone metastases

Conditions: Advanced Cancer; Bone Metastases

Summary: cancer which has spread to the bone, causing bone metastases (bone tumours) can weaken bone health and increase risk of fractures (breaks). consequently, patients can be unsure whether to exercise and health professionals can be unsure what exercise advice is suitable. despite this, it is well known that exercise improves quality-of-life for patients with bone metastases and therefore it is important that exercise is prescribed to these patients. this study aims to increase understanding of the link between daily exercise and risk of fracture in patients with bone metastases.

it remains unclear if being physically active increases the risk of skeletal-related events in patients with bone metastases. many health professionals report fracture risk as the primary concern with exercise prescription, despite a recognition of the importance of exercise participation. consequently, health professionals can be hesitant to offer exercise advice and many patients are physically inactive. with increasing evidence supporting the benefits of exercise in metastatic bone disease, there is a need to address exercise-related concerns. clinical scoring systems such as mirel's classification, are considered predictive of pathological fracture risk. while scoring algorithms have considerable potential to inform exercise eligibility in this population, to date the applicability of such clinical measures for exercise prescription have been inadequately studied. this study will examine the relationship between habitual physical activity, captured objectively by accelerometry, and skeletal related events (pathologic fracture, spinal cord compression, necessity for radiation to bone or surgery to bone pathological fracture) in patients with metastatic disease (n=100). clinical data including fracture risk and skeletal related events (sres), physical activity (pa) data and subjective measures of pain, sleep, quality of life (qol) and exercise barriers and benefits will be collected at baseline. fracture risk will be determined at baseline using mirel's classification, which will be assessed by a radiologist affiliated with the study research team. with treatment advances, patients with bone metastases secondary to advanced cancer are living longer. consequently, optimising quality-of-life is a key priority and exercise has many recognised benefits in this domain. this research will explore the association between daily activity levels and skeletal complications in patients with bone metastases, by examining methods of identifying patients who are suitable to exercise, therefore improving exercise prescription practice and exercise participation safety.

Eligibility criteria:
inclusion criteria: * diagnosis of bone metastases on radiological imaging as a result of breast, prostate or lung cancer. * initial systemic or local therapy post-diagnosis completed * commenced on bone modifying agents (bmas) * provide signed and dated informed consent form exclusion criteria: * cauda equina or metastatic spinal cord compression (mscc) * pre-existing chronic pain (persistent or recurrent pain lasting longer than 3 months) due to orthopedic, rheumatology or fibromyalgia condition

Keywords: physical activity skeletal related events