Kornimate/medical-research-clean huggingface dataset:
an observational prospective study to understand the usage pattern of ticagrelor with acs (acute coronary syndrome)

Conditions: Acute Coronary Syndrome

Summary: the treasure observational study is designed to address the need to understand the usage pattern of ticagrelor in real life scenario in large number of acs (acute coronary syndrome) patients in india. the aim of this national study is to understand the usage pattern (including the duration of treatment) of ticagrelor in various acs patient population undergoing pci (percutaneous coronary intervention), cabg (coronary artery bypass graft) or medical management in a real-life setting in india.

this study is a multi-centre, observational, prospective study to be conducted at 60 hospitals across indiathe study will be initiated after obtaining written approval of independent ethics committee (iec) and written informed consent of the patient. patients who had been hospitalized for acs and are on ticagrelor on discharge or on ticagrelor therapy for ≤ 1month will be enrolled in the study and followed up for a period of 12 months. during the follow-up period of up to 12 months (according to the label), assessment visits will follow the routine clinical practice. no visits or measurements will be made mandatory by the protocol

Eligibility criteria:
inclusion criteria: 1. written informed consent has been provided. 2. aged 18 years or older. 3. male/female with acs on ticagrelor on discharge or ≤ 1month. 4. patient underwent pci, cabg or mm (medical management) for acs. 5. diagnosis of stemi, nstemi or ua exclusion criteria: 1. patients with medical history of intracranial hemorrhage 2. all those patients who are not fit to receive ticagrelor as per the latest prescribing information

Keywords: acs
microwave and laser ablation study (most study)

Conditions: Varicose Veins of Lower Limb

Summary: to validate the safety and efficacy of microwave versus laser ablation of the great saphenous vein in patients with varicose veins of lower extremities

a prospective, multicenter, randomized, controlled clinical trial to validate the safety and efficacy of microwave versus laser ablation of the great saphenous vein in patients with varicose veins of lower extremities

Eligibility criteria:
inclusion criteria: 1. age 18 years or older, not older than 80 years, male or female 2. patients clinically diagnosed as primary great saphenous vein insufficiency with reflux lasting \> 0.5 seconds on duplex ultrasound 3. patients with ceap grade c2-c6 4. patients who voluntarily participate in this trial, understand all the risks and benefits described in the informed consent document, and sign the written informed consent form exclusion criteria: 1. patients with diameter of target lesion vein \ 15 mm 2. patients with previous surgical treatment on the target lesion or patients with acute thrombosis 3. patients with deep vein thrombosis and superficial vein thrombosis 4. patients with acute systemic infectious diseases 5. patients with severe liver and kidney dysfunction (alt \> 3 times the upper limit of normal value; creatinine \> 225 umol /l) 6. patients with known uncorrectable bleeding or severe coagulopathy 7. patients with anesthesia contraindications 8. patients with poorly controlled hypertension (systolic blood pressure ≥ 160 mmhg and/or diastolic blood pressure ≥ 100 mmhg) and diabetes mellitus (fasting glucose ≥ 10.0 mmol / l) 9. patients with non-primary varicose veins caused by post-deep vein thrombosis syndrome, kt syndrome (klippel-trenaunay syndrome), arteriovenous fistula, etc. 10. patients with other diseases that may cause difficulty in conducting the trial or evaluation, such as mental illness, aids, malignant tumors, liver disease, cardiac insufficiency, etc. or patients whose life expectancy is less than 1 year 11. pregnant, lactating women, or those planning on becoming pregnant during the trial 12. patients who have participated in clinical trials of other drugs or medical devices in the past 3 months 13. patients considered unsuitable for inclusion by investigators for other reasons

Keywords: endovenous microwave therapy（emt） endovenous laser treatment（evlt） great saphenous vein
a study to investigate the exposure and safety and tolerability of a single dose of fg-4592 in subjects with moderately diminished liver function compared to those with normal liver function

Conditions: PK of FG-4592; Hepatic Insufficiency; Healthy Subjects

Summary: the effect of moderately diminished liver function on the exposure, safety and tolerability of a single dose of fg-4592 is studied in male and female subjects. the results are compared to the data gained from subjects with normal liver function.

the effect of moderate hepatic impairment on the pharmacokinetics (pk), safety and tolerability of a single dose of fg-4592 in male and female subjects is investigated. data obtained from these subjects are compared to data from bmi-, age- and sex-matched subjects with normal hepatic function. both groups consist of 8 subjects. screening takes place from days -22 to -2 before admission to the clinical unit on day -1. administration of the trial medication takes place on day 1 under fasted conditions. healthy subjects are discharged on day 5 and subjects with moderate hepatic impairment on day 7, if there is no reason to extend the stay. an end-of-study visit (esv) takes place 5 to 9 days after (early) discharge. safety assessments are performed throughout the study.

Eligibility criteria:
inclusion criteria: both healthy subjects and subjects with moderate hepatic impairment: * independent ethics committee (iec)-approved written informed consent and privacy language as per national regulations must be obtained from the subject prior to any study-related procedures (including withdrawal of prohibited medication, if applicable). * male subjects and their female spouse/partners who are of childbearing potential must be using highly effective contraception consisting of 2 forms of birth control (1 of which must be a barrier method) starting at screening and continuing throughout the study period and for 90 days after the study drug administration. in addition, subjects with moderate hepatic impairment must also meet the following inclusion criteria: * subject has child-pugh classification class b (moderate, 7 to 9 points) liver function impairment \[screening\]. exclusion criteria: both healthy subjects and subjects with moderate hepatic impairment: * female subject who has been pregnant within 6 months prior to screening or breastfeeding within 3 months before screening. * subject has a known or suspected hypersensitivity to fg-4592, or any components of the formulation used. in addition, healthy subjects must also not meet the following exclusion criteria: * subject has any of the liver function tests (lft) (aspartate aminotransferase \[ast\], alanine aminotransferase \[alt\], alkaline phosphatase \[alp\], gamma glutamyl transferase \[ggt\], total bilirubin \[tbl\] above the upper limit of normal (uln). in such a case the assessment may be repeated once \[day-1\]. in addition, subjects with moderate hepatic impairment must also not meet the following exclusion criteria: * subject had a previous liver transplantation.

Keywords: phase 1 fg-4592 single dose moderate hepatic impairment
optimal duration of stretching exercise in patients with chronic mechanical neck pain

Conditions: Mechanical Neck Pain

Summary: controversy remains about the stretching parameters needed to achieve a particular goal or treatment outcome. in clinical practice, multiple stretching techniques are used; nevertheless, there is no evidence-based agreement on the most effective parameters. one of these parameters, that might be affecting the treatment outcome the most, is the stretching duration, thus far there is a little agreement on the optimal stretching duration. this non agreement in exact stretching parameters is obvious between authors and researchers in the field of muscle energy techniques (met) as well as those who have used and advocate various durations for the passive stretch that follows the contraction phase in met.

comparison and subsequent conclusions about appropriate stretching times are mainly based on mechanical factors such as range of motion and flexibility, while ignoring the neural adversative mechanical tension that may be created during stretching exercises. according to the literature , stretching induced neural tension may adversely affect the central nervous system and nerve root function due to the absence of the perineurium, which is the primary load carrying structure. thus, safe or unsafe limits of nerve elongation are not well established, despite several basic scientific and clinical studies.. consequently, in the present study, the current study aimed to answer the question: is it theoretically possible, that increased longitudinal strain and stress on the spinal cord and nerve root from continuous stretching exercises may subtly impair the neural function? our hypothesis is that a duration threshold exists where, once reached, adverse neural function will be apparent resulting in a reduction of either or both latency and amplitudes of evoked potentials.

Eligibility criteria:
inclusion criteria: * eligible patients had to be between 18 and 40 years of age * have generalized neck pain for more than 3 months. * with symptoms provoked by neck postures, movements, or palpation exclusion criteria: * subjects' exclusion criteria included specific neck pain due to trauma, disc protrusion, whiplash, congenital deformity of the spine, spinal stenosis, neoplasm, inflammatory or rheumatic disease. furthermore, subjects were excluded if they had a history of spine surgery and any objective findings consistent with neurological conditions and vascular disorders.

Keywords: randomized controlled trial muscle energy technique stretching exercises
application of molecular techniques for improving the diagnosis and treatment of nodular thyroid lesions.

Conditions: Papillary Thyroid Carcinoma

Summary: to determine the improvement in diagnosis of papillary carcinoma by detecting mutation v600e braf in retrospective cases with inconclusive cytologic diagnosis (categories iii, iv and v of bethesda system)

aim of the study to determine the improvement in diagnosis of papillary carcinoma by detecting mutation v600e braf in retrospective cases with inconclusive cytologic diagnosis (categories iii, iv and v of bethesda system). design: retrospective observational study. scope: the study will be peformed at the pathology service, from cytological samples and paraffin file post-diagnosis. mutations are detected by pyrosequencing technique. subject of study: cases with histological diagnosis of papillary carcinoma (cp) and previous cytological diagnosis in groups iii, iv and v bethesda, collected between october 1989 and july 2014 in corporació parc taulí. methodology: * identification of cases * detection of braf v600e mutation, initially in histological material from the surgical specimen, and if present, detection in cytological material. the statistical analysis will use spss. univariate and bivariate analysis will be done. results will be presented in the form of frequency tables and percentages for qualitative variables and by average, median and standard deviation for quantitative variables. pearson chi-square or fisher's exact test will be applied. the student t test or the mann-whitney test will be performed for quantitative variables.

Eligibility criteria:
inclusion criteria: * cases with histological diagnosis of papillary carcinoma (cp) and previous cytological diagnosis in groups iii, iv and v bethesda, collected between october 1989 and july 2014 in corporació parc taulí exclusion criteria: * non available cytological or histological material
risk factor analysis for coronary atherosclerosis measured by mdct

Conditions: Atherosclerosis; Metabolic Syndrome

Summary: coronary mdct (multi-detector computed tomography) has been useful screening imaging modality for the coronary artery disease. recently, novel adipokines and hepatokines as well as various inflammatory markers have been known as direct regulators of atherosclerosis. therefore, the investigators examine the correlation of various metabolic risk factors including adipokines and hepatokines with coronary atherosclerosis measured by coronary mdct in apparently healthy people.


Eligibility criteria:
inclusion criteria: * apparently healthy people who underwent medical routine check up in korea health promotion center. * age \> 20 years exclusion criteria: * history of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization) * diabetes * stage 2 hypertension * severe renal or hepatic disease
hsat for osa management in children

Conditions: Sleep Apnea, Obstructive; Sleep Disorder; Sleep Apnea Syndromes; Sleep Disturbance

Summary: this clinical trial will compare the diagnostic accuracy of type ii hsat with psg for determining osa status following treatment with adenotonsillectomy in children

many children have residual obstructive sleep apnea (osa) following adenotonsillectomy, but in-lab polysomnography (psg), the recommended means of re-evaluating these patients, is resource-intensive and availability is limited. home sleep apnea testing (hsat), a similar test performed in the patient's home and used clinically in adults, may offer an alternative means of evaluating the effect of osa treatment in children and make testing more convenient and widely available.

Eligibility criteria:
inclusion criteria: * male and female children age 5-12 years old inclusive * history of adenotonsillectomy for osa exclusion criteria: * children with a history of hypoventilation or hypoxemia or who require supplemental oxygen or positive airway pressure during sleep * children with a tracheostomy or tracheocutaneous fistula * children who live in a facility without their parent

Keywords: obstructive sleep apnea home sleep apnea testing
fibroscan® and its dedicated probes efficiency in obese patients

Conditions: Liver Fibrosis; Cirrhosis

Summary: the main objective of the study is to evaluate the diagnostic performance of the xl probe for estimating degree of liver fibrosis/cirrhosis in obese patients \> 28 kg/m² with various liver diseases in patients with chronic liver disease scheduled for a liver biopsy.


Eligibility criteria:
inclusion criteria: * patient of at least 18 years of age * patient able to give written informed consent form * patient with a bmi superior or equal to 28kg/m² * patient scheduled to have a liver biopsy within 1 month after the enrollment or with a liver biopsy performed within 6 months before the enrollment. * patient for which abdominal ultrasound is technically possible exclusion criteria: * unable or unwilling to provide written informed consent * confirmed diagnosis and/or history of malignancy, or other terminal disease * patients with clinical ascites * pregnant women * patient with a bmi \< 28 kg/m² * patients with any active implantable medical device (such as pacemaker or defibrillator) * transplanted patient and patient with heart disease * refusal to undergo a liver biopsy

Keywords: adult patients with chronic liver disease scheduled for a liver biopsy and a bmi superior or equal to 28 kg/m²
scoring systems covid19

Conditions: ICU Scoring System in Covid 19

Summary: in this study, we planned to investigate the role and determine the predictive performance of both apache ii and saps ii scoring systems and compare them in covid-19 patients admitted to the intensive care unit of assiut university hospital.

since the start of the coronavirus disease 2019 (covid-19) pandemic, intensive care units (icus) worldwide have struggled to treat affected patients who require a completely different approach to treatment than other patients * \[1\]\* .this study aims to evaluate the efficacy of single dose analgesia in combination with local anaesthesia to control pain during tus guided procedures. it also aims to assess the effect of its use on procedure performance time and rate of complications occurrence compared to local anaesthesia alone.although many severe cases are admitted to icus, it is unknown whether the conventional disease-severity scoring systems that were developed for icu patients can be applied to patients with covid-19.several recent studies have used acute physiology and chronic health evaluation (apache) and simplified acute physiology score (saps) to provide information on the clinical severity of covid-19 * \[2-4\]\*. however, very few reports have examined their validity of applying them to patients with covid-19.

Eligibility criteria:
inclusion criteria:• * • this study will be conducted on laboratory-confirmed covid-19 patients who will be transferred to the intensive care unit of assiut university hospital exclusion criteria: * patients would be excluded from this study if they died or were discharged from the intensive care unit prior collection of data required for both the apache ii and saps ii scoring systems, if they were discharged before their outcomes were determined and if we could not obtain consent from them or their companions to participate in this study. all patients involved will be subjected to a full history with special stress on age, gender, special habits, and associated diseases. information such as the patient's need for ventilatory support as well as the length of icu stay will be entered. also, the laboratory results and imaging findings will be registered. scores of apache ii and saps ii were calculated as illustrated in the previously published works \*\[5,6\]\* .patients will be followed up until their outcome was determined.
vitamin d supplementation in conscripts

Conditions: Vitamin D Deficiency; Military Activity

Summary: a longitudinal, triple-blinded, randomized, placebo-controlled trial, with a 7-month follow-up period is conducted between october 2016 to april 2017.

body mass (kg) and height (cm) is measured by the same person at the medical center using standardized equipment and the body mass index (bmi) is calculated in kg/m2. computed randomization is used to divide conscripts into two groups; either the intervention group or the control group. both types of capsules are administered once per day in the morning before breakfast for 7 months. standardized coded packages (3 per conscript) and capsules (100 per package) are manufactured on a special order by innopharma a/s (denmark). no commercial sponsoring is involved. the key of the package code is stored in the computer database until unblinding of the results. laboratory measurements serum samples for clinical chemistry analysis are collected into serum clot activator tubes. calcium measurements are performed using spectrophotometry method. ionized calcium measurements are performed using ion selective electrodes. the direct chemiluminescent immunoassay method is used for measurement of pth. 25(oh)d is measured using direct chemiluminescent immunoassay method. power calculation the primary variable of the study is the level of 25 (oh)d in the serum. in the power analysis a difference of 20 nmol/l between the intervention and the control group is considered to be meaningful to detect. if the sd would be 25 nmol/l, then 26 participants would be needed in each group to reach a power of 80%. statistical analysis the distribution of blood serum values in the study groups is described by means and standard deviations (sd). differences in mean values of the variables of interest between the groups are evaluated using welch t-test. the within group comparisons over time are performed using paired t-test with bonferroni correction. distributions of categorical variables are described by absolute numbers and percentages and compared between groups using the fisher exact test. statistical significance is set at the 0.05 probability level.

Eligibility criteria:
inclusion criteria: * participating in military service at the estonian defence forces * voluntarity to participate in the study exclusion criteria: * inability to continue military service for any reason, during the 7 month follow-up period
mitochondrial remodeling after exercise

Conditions: Overweight and Obesity; Insulin Resistance; Metabolic Disease; Mitochondrial Metabolism; Sedentary Lifestyle

Summary: regulation of mitochondrial health in overweight and obese individuals may be impaired. the purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. the investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.


Eligibility criteria:
inclusion criteria: * age 18-45 years * body mass index (bmi) 18-45 kg/m2 * sedentary (\<1 hour of planned exercise per week) exclusion criteria: * regular exercise (\>1 hour of planned exercise per week) * smoking, tobacco or nicotine use within the last 1-year * fasting glucose \>126mg/dl * hypertension (systolic pressure \>140 mmhg or diastolic pressure \>90 mmhg) * chronic metabolic or cardiovascular health conditions * pregnant, nursing, irregular menses or post-menopausal * lidocaine allergy * certain medications * physical limitations that prevent safe or successful exercise completion * diminished capacity for consent
preventing contrast-induced nephropathy: evaluating hydration strategies and l-carnitine administration

Conditions: Acute Kidney Injury; Renal Insufficiency

Summary: the general objective of this open, pilot study is to characterize biological parameters related to acute kidney injury among patients undergoing a programmed coronarography with injection of contrast material. the study focuses on two main factors that may influence acute kidney injury: (1) sodium chloride hydration strategy versus sodium bicarbonate hydration strategy and (2) presence of oral l-carnitine treatment versus absence of oral l-carnitine treatment. we will also test for a potential interaction between these two factors.


Eligibility criteria:
inclusion criteria: * the patient must have given his/her informed and signed consent * the patient must be insured or beneficiary of a health insurance plan * the patient is scheduled for a coronarography * the patient can come back to the hospital on days 2 and 7 after the coronarography for follow up * the patient has moderate to severe renal insufficiency (glomerular filtration rate \< 60 ml / min / 1.73 m\^2) * the patient has not had any oral antidiabetic treatments, or diuretic treatments, within 48 hours preceding the coronarography * lack of treatment with ace inhibitors or ara2 24 hours prior to coronary exclusion criteria: * the patient is participating in another study * the patient is in an exclusion period determined by another study * the patient is under judicial protection * the patient is under any kind of guardianship * the patient refuses to sign the consent form * it is impossible to correctly inform the patient * the patient is unable to participate in follow-up visits at days 2 and 7 after the coronarography * the patient is pregnant or breastfeeding * the patient is taking l-carnitine * the patient has a contra indication for a treatment used in this study * acute heart failure * infarction, acute phase * hemodialysis patient * myeloma * epileptic patient treated with depakine (valproic acid) (carnitine can lower epilepsy-related thresholds by speeding up the metabolism of depakine)

Keywords: contrast induced nephropathy hydration strategy l-carnitine