Kornimate/medical-research-clean huggingface dataset:
effectiveness of ultrasound guided adductor canal block on chronic pain in knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: adductor canal block has become popular as effective mean for pain relief following knee surgery.this block has not been checked in chronic pain patients.the purpose of this study is to assess the efficacy and safety of adductor canal block on chronic knee pain in patients with knee osteoarthritis.

knee osteoarthritis is serious epidemiologic problem. knee prosthesis is successful treatment for many of patients with advanced knee osteoarthritis but there are important numbers of patients, which are not appropriate candidates for such surgery treatment. for them ,any treatment which could relieve pain in their knee would have good impact on quality of life. adductor canal block is successfully used for relieving postoperative pain after knee surgery. official approval from ethics committee of republic slovenia was obtained for this study. after being informed about the study and potential risks, all patients giving written informed consent will undergo an orthopedic examination and those with confirmed diagnosis of knee osteoarthritis lasted more than 6 months will be included in the study. prior to start they filled knee injury and osteoarthritis outcome(koos) form and estimate maximal and minimal intensity of pain in the knee .they repeat self assessment of pain at the same manner using 11 point numeric rating score(nrs) 1 week and 1 month after blockade.measurement of maximum voluntary isometric contraction of quadriceps muscle (mvic) ,time up and go test(tug) and 30s chair stand test are performed by physiotherapist before block of adductor canal on the ipsilateral leg ,1 hour,1 week and 1 month after block..block of adductor canal is performed by the same and trained anesthesiologist at the proximal part of the leg using 14 ml of levobupivacaine and 100 mcg clonidine mixed in the same syringe.at the conclusion of study patients filled the knee injury and osteoarthritis outcome(koos) form once again.

Eligibility criteria:
inclusion criteria: outpatients had pain in knee at least 6 months before the study knee osteoarthritis chronic pain was diagnosed based on medical history, knee x- ray and orthopedic examination. a sufficient level of education to understand study procedures and be able to communicate with site personnel - exclusion criteria: * any cardiovascular, hepatic, or renal conditions that would compromise participation, in the opinion of the investigator * severe neurologic conditions interfere with knee condition * narcotic dependent (opioid intake more than 3 months and more than 30 mg of daily oral morphine equivalents) * coexisting severe hematological disorder or with deranged coagulation parameters * psychiatric illnesses * allergy to any of the drugs used in the study * infection or malignancy at the site of block * any active systemic infection
translation, cultural adaptation and validation of the italian version of functional rating index in patients with chronic low back pain

Conditions: Low Back Pain

Summary: chronic low back pain (clbp) is a global health issue lasting more than 3 months, where a clear pathologic and anatomic cause of pain is not recognized. various personal and psychosocial factors can influence the onset and chronicity of low back pain. the functional rating index (fri) is a self-administered questionnaire composed by 10 items, scored from 0 (better condition) to 4 (worst condition), that evaluate pain, sleep, work and daily activity. the fri's final score ranges from 0% to 100% (no disability to severe disability). the aim of the study is to translate, culturally adapt and validate the fri in italian (i-fri).

chronic low back pain (clbp) is a global health issue lasting more than 3 months, where a clear pathologic and anatomic cause of pain is not recognized. various personal and psychosocial factors can influence the onset and chronicity of low back pain. an outcome measure, in a specific context, refers to a quantifiable or observable variable used to assess and evaluate the results or effects of a particular intervention, treatment, program, or research study. the choice of appropriate outcome measures is critical in research and evaluation because it directly influences the validity and reliability of the results. there are already other validated scales translated in italian for the evaluation of patients with clbp, such as the oswestry disability index (odi-i). the functional rating index (fri) is a self-administered questionnaire composed by 10 items, scored from 0 (better condition) to 4 (worst condition), that evaluate pain, sleep, work and daily activity. the fri's final score ranges from 0% to 100% (no disability to severe disability). the aim of the study is to translate, culturally adapt and validate the fri in italian (i-fri). 104 patients were recruited for this study following inclusion/exclusion criteria. after signing the informed consent, each participant completed i-fri, oswestry disability index (odi), tampa scale of kinesiophobia (tsk) and pain catastrophizing scale (pcs). all the patients have done the i-fri re-test after 7 days from the first test administration. all statistical analyses have been performed using ibm-spss (statistical package for the social sciences) version 23.00. the results have been analyzed through the calculation of the cronbach's alpha, the intraclass correlation coefficient (icc) and the pearson's correlation coefficient.

Eligibility criteria:
inclusion criteria: * chronic low back pain * adult age * reading/speaking italian. exclusion criteria: * acute low back pain (lasting up to 4 weeks) or subacute low back pain (lasting up to 12 weeks). * cognitive impairment. * disabling pathological conditions.
sonographic measurement of intraneural blood flow in the median nerve

Conditions: Carpal Tunnel Syndrome; Median Nerve Injury

Summary: carpal tunnel syndrome (cts) is the most common nerve compression disease and the most expensive upper-extremity work-related musculoskeletal disorder, affecting approximately 10 million people in the us. to understand the clear etiology and mechanism of carpal tunnel syndrome, the measurement of median nerve intraneural blood flow needs to be further scrutinized as the common fluctuating physiological conditions and functional hand activities might contribute to the fluctuation of the measurement and serve as measurement error. this study aims to examine how intraneural blood flow within the median nerve is affected by physiological factors (i.e., body temperature and blood pressure) and functional hand activities (i.e., typing, using a mouse, and cooking).


Eligibility criteria:
inclusion criteria: * aged 18 to 65 * english-speaking * ability to endure a moderate-intensity physical activity * ability to type without looking at the keyboard exclusion criteria: * pain, tingling, or numbness in the hand or wrist region within the past week * history of corticoid injection in the upper extremity * history of surgery in the wrist region * carpal tunnel syndrome * amyotrophic lateral sclerosis * diabetes * hypothyroidism * pregnant * positive phalen's test * persistent median artery within wrist region * bifid median nerve

Keywords: intraneural blood flow
evaluation of the samsung labgeo pt10 hepatic panel in a point-of-care setting

Conditions: Hepatic Disease

Summary: to establish the performance characteristics of the samsung labgeo pt10 by comparing the test results of the pt10 hepatic assay with results obtained from an fda-cleared chemistry analyzer.

to establish the correlation between measurand values as obtained from the samsung labgeo pt10 hepatic panel at the point of care, and the corresponding measurand values as obtained on a commercial clinical chemistry analyzer, with respect to prospectively collected human serum specimens.

Eligibility criteria:
inclusion criteria: * male or female subjects with a history of elevated liver enzymes or symptoms suggestive of elevated liver enzymes * presenting to the site and requiring testing for levels of liver enzymes as part of routine care at the site * subjects able and willing to provide written informed consent exclusion criteria: * subjects unable or unwilling to provide written informed consent * subjects with a life-threatening disease or any serious, potentially life-threatening medical illness that may compromise patient safety or study conduct
possum, p-possum and charlson's comorbidity index in abdominal surgery.

Conditions: Postoperative Complications

Summary: abdominal surgery represents the most frequent activity in the surgical block. advances in surgical techniques and improvements in postoperative care imply the need for greater control of the surgical outcomes obtained and the comparison of results between services with the same characteristics with the help of assessment scales. a prospective observational study will be carried out during 2021. all patients undergoing abdominal surgery will be included. demographic variables, personal and surgical history, preoperative and intraoperative data, and variables related to surgery will be collected. at 30 days postoperatively, the clinical history of the patients will be reviewed and postoperative complications will be collected as well as the mortality that occurred. with these data, the possum, the p-possum and the charlson comorbidity index will be calculated.

abdominal surgery represents the most frequent activity in the surgical block. advances in surgical techniques and improvements in postoperative care imply the need for greater control of the surgical outcomes obtained and the comparison of results between services with the same characteristics with the help of assessment scales. a prospective observational study will be carried out during 2021. all patients undergoing abdominal surgery will be included. demographic variables, personal and surgical history, preoperative and intraoperative data, and variables related to surgery will be collected. at 30 days postoperatively, the clinical history of the patients will be reviewed and postoperative complications will be collected as well as the mortality that occurred. with these data, the possum, the p-possum and the charlson comorbidity index will be calculated. once this data are collected, the following objectives will be met: * validate the possum and p-possum systems in patients undergoing gastrointestinal surgery in our hospital, comparing the estimated morbidity and mortality with that observed 30 days after surgery. * analyze the correlation of estimated morbidity and mortality of the possum and p-possum with respect to that observed in scheduled surgery vs. emergencies. * analyze the correlation of estimated morbidity and mortality of possum and p-possum with respect to that observed in laparoscopic surgery vs. laparotomy * establish the relationship and predictive ability of chf with respect to morbidity and mortality at 30

Eligibility criteria:
inclusion criteria: * all patients undergoing scheduled or urgent intervention for gastrointestinal surgery will be included in the study. exclusion criteria: * patients operated under locoregional anesthesia. * patients undergoing major ambulatory surgery (cma) regardless of postoperative destination (home or hospitalization floor). * patients intervened on a scheduled basis in the afternoon shift * patients who require surgery after the first 24 hours of hospital admission

Keywords: postoperative complications abdominal surgery urgent surgery
iron deficiency in heart failure patients

Conditions: Heart Failure

Summary: heart failure is a common problem with a prevalence of 1-2% in general population and a major cause of mortality,morbidity and impaired quality of life. anemia is afrequent comorbidity in stable heart failure patients and it increases morbidity in terms of frequent hospital admissions,impaired exercise capacity,poor quality of life ,and increased mortality

iron deficiency with or without anemia has been commonly associated with heart failure .although iron deficiency is the commonest nutritional deficiency worldwide ,affecting more than one-third of the population,its association with heart failure with or without anemia is of growing interest .as iron supplementation improves prognosis in patients with heart failure ,iron deficiency is an attractive therapeutic target. in 2012 ,the european society of cardiology guidelines for the diagnosis and treatment of acute and chronic heart failure recognized iron deficiency as a comorbidity in heart failure for the first time and recommended diagnosis of iron deficiency based on iron parameters in all patients suspected of having heart failure. iron deficiency can be classified as absolute or functional. absolute iron deficiency reflects depleted body stores caused by poor dietary intake, impaired gastrointestinal absorption,and chronic blood loss. functional iron deficiency is thought to be caused by increased hepcidin production and subsequent inhibition of the iron exporter ferroportin ,leading to impaired absorption and utilization of iron. chronic heart failure patients are susceptible to both forms iron deficiency aetiology of iron deficiency in chronic heart failure: the aetiology is multifactorial and complex 1. reduced dietary intake 2. chronic blood loss 3. chronic heart failure causes an inflammatory state which leads to increased hepcidin levels and subsequent iron deficiency due to reduced iron absorption and enhanced reticuloendothelial block

Eligibility criteria:
inclusion criteria: .100 males or females patients above age of 18years of age and clinically diagnosed with systolic heart failure,ejection fraction\<50% by echocardiography admitted in assiut university hospital exclusion criteria: .known to be non cardiac condition causing iron deficiency(haemorrhoids,malignancy). .other conditions causing fluid overload(eg.renal failure on dialysis ). .congenital heart disease.
effect of varithena on wound healing in venous leg ulcers (vlu)

Conditions: Venous Leg Ulcer

Summary: a 12 month, multicenter, open-label registry to observe chronic venous insufficiency resulting in vlu treated with varithena.

this 12 month, multicenter, open-label registry is designed to collect treatment and outcome data related to participants treated with varithena for great saphenous vein (gsv) system and/or anterior accessory saphenous vein (aasv) incompetence resulting in vlu. participant are treated per investigator's standard of care (soc) and in accordance with the full prescribing information (fpi) and instructions for use (ifu). for participants with healed ulcers during the 12 month follow-up period, vlu recurrence information is collected.

Eligibility criteria:
inclusion criteria: * men and women; age ≥18 * investigator has selected varithena® to treat participants classified c6 with chronic (≥3 months) vlu resulting from gsv and/or aasv incompetence * wound can be visualized in one plane to allow for image collection of the entire wound in one photograph, or if wound is circumferential, participant must be able to capture the entire wound using multiple photographs taken from directly above the wound (straight on) * reflux \>500 milliseconds (ms) on duplex ultrasound * willing and able to collect wound photographs and data using an application installed on a tablet * willing and able to return for scheduled follow-up and wound care visits * ability to comprehend and sign informed consent form (icf) and complete questionnaires exclusion criteria: * contraindications to varithena® 1% in accordance with the fpi * any serious concomitant disease, per physician's discretion, that confounds wound healing, including malignant changes of wound * concomitant heat ablation, or heat ablation of index leg within 6 weeks prior to treatment with varithena® * significant arterial disease or ankle-brachial pressure index (abpi) ≤0.8 * in the opinion of investigator, wound would close within 12 weeks without additional treatment

Keywords: gsv aasv vein venous ulcer varicose vein vlu venous insufficiency venous disease chronic vlu
a study to evaluate the safety of nivolumab and ipilimumab in subjects with previously untreated advanced or metastatic renal cell cancer

Conditions: Renal Cell Carcinoma

Summary: to investigate the safety of nivolumab in combination with ipilimumab in subjects with previously untreated advanced or metastatic renal cell cancer.


Eligibility criteria:
inclusion criteria: 1. type of participant and target disease characteristics 1. advanced or metastatic rcc 2. histologically confirmed, previously untreated (treatment-naive) rcc 3. no prior systemic therapy for rcc except for one prior adjuvant or neoadjuvant therapy for completely resectable rcc 4. measurable disease as per recist 1.1. subject must have extracranial metastasis as measurable disease 5. karnofsky performance status (kps) of at least 70% for cohort 1, 2, and 3; kps of 50-60% for cohort 4 6. tumor tissue need be received by the central vendor (block or unstained slides). note: fine needle aspiration (fna)and bone metastases samples are not acceptable for submission. exclusion criteria: 1. medical conditions 1. subjects with any active autoimmune disease or a history of known autoimmune disease 2. prior malignancy active within the previous 3 years except for locally curable cancers that have been apparently cured 3. known hiv or aids-related illness 4. any positive test for hepatitis b or hepatitis c virus indicating acute or chronic infection. 2. prior/concomitant therapy 1. prior systemic treatment in the metastatic setting with vascular epithelial growth factor(vegf) or vegf receptor targeted therapy 2. prior treatment with an anti-programmed death (pd) -1, anti-pd-l1, anti-pd-l2, anti-cluster of differentiation 137 (cd137), or anti-cytotoxic t-lymphocyte-associated antigen 4(ctla-4) antibody, or any other antibody or drug specifically targeting t-cell co-stimulation or checkpoint pathways. this includes the utilization of these agents in the neo-adjuvant or adjuvant setting. 3. anti-cancer therapy less than 28 days prior to the first dose of study drug or palliative, focal radiation therapy less than 14 days prior to the first dose of study drug. other protocol defined inclusion/exclusion criteria apply
multi-pronged ethanol ablation and radiofrequency ablation of early-stage hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is to compare the effectiveness of percutaneous ethanol ablation using a multi-pronged needle (qfea) with that of percutaneous radiofrequency ablation (rfa) in the treatment of early-stage hepatocellular carcinoma (hcc).

patients with early-stage (single tumor no more than 5 cm or up to 3 tumors each no more than 3 cm in size) primary hepatocellular carcinoma will be randomized into two percutaneous ablation treatment arms, including radiofrequency ablation and multi-pronged ethanol ablation. the local treatment responses, complications,and long-term disease-free survivals and overall survivals are analyzed.

Eligibility criteria:
inclusion criteria: * primary hepatocellular carcinoma, single tumor ≤5 cm or up to 3 tumors each ≤3 cm * ultrasound detectable tumor * liver function classified as child-pugh a or b * platelet count \> 50,000/mm3, or prothrombin activity \> 50% * not suitable for resection or patient refused surgery exclusion criteria: * vascular invasion and extrahepatic spread * patients allergic to ethanol

Keywords: hepatocellular carcinoma pei rf ablation tumor ablation
efficacy of combined blood clot and platelet rich fibrin scaffolds in regeneration of necrotic immature permanent teeth

Conditions: Pulp Necroses

Summary: the aim of the present study is to assess clinically and radio-graphically the regenerative potential of immature permanent teeth with necrotic pulp using blood clot and platelet rich fibrin scaffolds.

30 immature necrotic permanent teeth in patients will be allocated and divided into two groups. group 1 will be treated by regenerative procedure using blood clot as a scaffold and group 2 will be treated with regenerative procedures using combined blood clot and platelet rich fibrin as a scaffold.

Eligibility criteria:
inclusion criteria: * necrotic incisors with immature roots * pulp space not needed for post and core. * the patient has to be free from any coagulation disorders, with normal platelets count. * good oral hygiene * cooperative patient exclusion criteria: * internal or external root resorption. * root fracture and/or alveolar fracture. * previous root canal treatment. * medically compromised patients * uncooperative patient

Keywords: regenerative endodontics open apex immature necrotic teeth
task-oriented rehab with saeboflex: impact on independence, visual motor skills, and depression in stroke patients

Conditions: Stroke; Depression; Splints

Summary: objective: the saeboflex orthosis is designed to assist individuals with upper extremity weakness in performing repetitive tasks. this study is planned to evaluate its effectiveness in improving upper extremity functions in stroke patients. methods: a randomized controlled study is planned to be conducted with 30 stroke patients, who will be divided into a control group (15 patients) and an intervention group (15 patients). the intervention group will receive task-oriented training with the saeboflex splint for 12 weeks, twice a week for 45 minutes, in addition to regular rehabilitation. the control group will continue with standard rehabilitation. planned outcome measures include the brunnstrom stages, stroke impact scale, fugl-meyer assessment, action research arm test, joint range of motion, and beck depression inventory. non-parametric tests will be used for statistical analysis.


Eligibility criteria:
inclusion criteria: * stroke occurrence at least 6 months prior * score of 23 or higher on the standardized mini mental test * brunnstrom stage 2 or 3 * ability to maintain sitting balance * active shoulder and elbow flexion of 15 degrees or more * wrist extension with finger extension of 15 degrees or more * active finger flexion up to 25% of a full fist position exclusion criteria: * presence of another neurological, orthopedic, or psychiatric problem causing activity limitation * previous use of the method being studied

Keywords: occupational therapy activities daily living neurorehabilitation