Kornimate/medical-research-clean huggingface dataset:
type i diabetes and non-surgical periodontal treatment

Conditions: Type 1 Diabetes; Periodontitis; Periodontal Diseases; Diabetes; Diabetes Mellitus; Diabetes Mellitus, Type 1

Summary: current evidence suggests a bidirectional association between periodontitis and diabetes. periodontal therapy improves short term hba1c levels and is safe to perform. most studies are focused on type 2 diabetes. literature about the correlation between periodontitis and type 1 diabetes is scarce, since no randomized clinical trials have been performed. the objective of the present clinical investigation is to evaluate the effects of nonsurgical treatment of periodontal disease on glycemic variability in patients with type 1 diabetes (t1dm). the hypothesis is that nonsurgical periodontal therapy affects glycemic variability in terms of time spent in hyperglycemia.


Eligibility criteria:
inclusion criteria: * diagnosis of type 1 diabetes * patients under treatment in the department of diabetology of aou careggi having a microinfusor for continuous subcutaneous insulin infusion (csii) and a flash glucose monitoring (fgm) device * diagnosis of periodontitis (all stages and grades) exclusion criteria: * contraindications for non-surgical periodontal therapy * pregnancy * history of other systemic disease (cancer, hiv, bone metabolic dysease, head and neck radiotherapy, immunosuppressive/modulating therapy)
the effect of hinge location on corneal sensation and dry eye after lasik: a systematic review and meta-analysis

Conditions: Dry Eye

Summary: the purpose of this study is to investigate the possible effect of hinge location on corneal sensation and dry eye syndrome after laser in situ keratomileusis (lasik).

dry eye symptoms are a frequent postoperative complication of laser in situ keratomileusis (lasik). although estimates of the incidence of dry eye syndrome vary widely, from 3% to 59%, almost all patients will have transient dry eye during the immediate postoperative period.because of the variability in corneal innervation patterns, altering flap characteristics in lasik may affect postoperative corneal sensation and dry-eye disease. some studies have reported that postoperative corneal sensation may be higher and recovery faster in eyes with horizontal flaps (nasal- or temporal-hinge) than in eyes with vertical flaps (superior- hinge). however, some other studies have not established an association between corneal sensation and hinge position. this study reviewed the published literature and performed a meta-analysis aimed to investigate the effects of hinge location on corneal sensation and dry-eye symptoms after lasik.

Eligibility criteria:
inclusion criteria: 1. each trial should be a prospective randomized controlled clinical trial (rct), 2. the age of patient population should be over 18 years exclusion criteria: 1. non-randomized controlled trials 2. patients who had had a previous ophthalmic surgery or ocular surface disorders 3. the raw data was not completed

Keywords: hinge position dry eye
methylome study in sporadic limb malformations

Conditions: Amelia; Femur Fibula Ulna Syndrome

Summary: some limb malformations are known to be sporadic (non hereditary). for these malformations, no molecular cause was identified, even after whole genome sequencing. methylation of cpg islands is an epigenetic process which is usually not transmitted to the descents. we hypothesize that sporadic limb malformations may be due to a methylation anomaly. this study will include patients with amelia or femur fibula ulna syndrome. with patients consent, we will study the methylome on dna samples already available in our laboratory. each patient sample will be paired to a control of same tissue, age and sex. by bioinformatics comparison, we will identify differentially methylated candidate regions.


Eligibility criteria:
inclusion criteria: * specific consent for this study * dna available in the laboratory * for amelia : agenesia of 2 or 4 limbs * for femur-fibula-ulna syndrome : hypoplasia or agenesia of the femur uni or bilateral with hypoplasia or agenesia or bowing of the fibula and/or of the ulna exclusion criteria: * no consent * no available dna or poor quality of the dna sample * patient under tutorship * pregnancy or nursing mother * patient non covered by the french social security

Keywords: amelia femur-fibula-ulna syndrome methylation limb development gene regulation
prevalence of lidocaine ineffectiveness in adults with and without adhd

Conditions: ADHD; PMS

Summary: this work will assess the prevalence in the general population of the ineffectiveness of the anesthetic lidocaine compared to males with adhd and females with adhd with or without pms.

using a non-invasive, pain-free, taste-based approach to assess lidocaine effectiveness, the study will assess the frequency of ineffectiveness in the target population. we will use an identical protocol at two sites: jacobi hospital and boston clinical trials. the controlled trial will assess the ability of lidocaine oral gel to block taste (e.g., sweet) in 100 teens and adults, half with a history of adhd, and for females, we will compare the sub-groups with and without premenstrual syndrome (pms). this study will also be compared with a similar assessment among a specialized adhd population (nct03563573), that does not respond to existing medication..

Eligibility criteria:
inclusion criteria: exclusion criteria for both arms: (1) known adverse reactions to lidocaine; (2) adhd, add, and other inattention disorders; (3) epilepsy, iq \<80, severe head trauma, birth weight \<2270 grams, and severe autism; (4) treatment currently with potassium or potassium-elevating drugs such as renin-angiotensin-aldosterone blockers; (5) generalized anxiety disorders (but dental-specific anxiety will not be an exclusion because many of these individuals may be ones with anxiety because of painful dental experiences with lidocaine ineffectiveness); (6) mouth sores; (7) ehlers danlos syndrome, (8) red hair, and (9) current pregnancy.
the efficacy and safety of using tranexamic acid to reduce blood loss in simultaneous bilateral total knee arthroplasty

Conditions: Blood Loss

Summary: a randomized, double-blind, single-center and controlled study comparing the efficacy and safety of intravenous administration of tranexamic acid to reduce blood loss in simultaneous bilateral total knee arthroplasty.

a randomized, double-blind, single-center and controlled study comparing the efficacy and safety of intravenous administration of tranexamic acid to reduce blood loss in simultaneous bilateral total knee arthroplasty. subjects will be monitored for occurrence of any complications, particularly deep venous thrombosis and thromboembolism during the hospital stay and for 1 months postoperatively.

Eligibility criteria:
inclusion criteria: * adult patients who plan to undergo simultaneous primary total knee arthroplasty on bilateral knee joint with a diagnosis of osteoarthritis or aseptic bone necrosis, but not of rheumatoid arthritis; * all patients who have normal preoperative platelet count, normal prothrombin time, normal partial thromboplastin time, and normal international normalized ratio; * the use of only balanced electrolyte solutions and/or albumin for plasma volume restitution exclusion criteria: * allergy to tranexamic acid; * receiving warfarin or heparin; had a history of hemophilia, deep venous thrombosis, pulmonary embolism, or renal impairment; or were pregnant; * patients with any cardiovascular problems (such as myocardiac infarction history, atrial fibrillation, angina); * patients with thromboembolic disorders, or those exhibiting a deteriorating general condition; * preoperative anemia (a hemoglobin value of \<11 g/dl in females and \<12 g/dl in males), refusal of blood products; * preoperative use of anticoagulant therapy within five days before surgery, fibrinolytic disorders requiring intraoperative antifibrinolytic treatment, coagulopathy (as identified by a preoperative platelet count of \ 1.4, or a prolonged partial thromboplastin time \[\>1.4 times normal\]).
rate of microbial colonization over native calcified cardiac valves

Conditions: Degenerative Cardiac Valve Disease; Coronary Artery Bypass Surgery Patients

Summary: the purpose of this observational, exploratory study in patients undergoing any cardiac valve replacement or repair is to assess the rate of bacterial colonization over native degenerative calcified cardiac valves.


Eligibility criteria:
inclusion criteria: * written informed consent must be obtained from the subject or his/her legal guardian before any assessment is performed * male or female subject, 50 years or older * subjects are scheduled to go through any cardiac valve replacement or repair due to degenerative calcified process. for control, subjects with no evidence of valve disease exclusion criteria: * subjects have an established or indicated history of ie. * subjects have complaint that might indicate ie- intermittent fever and physical finding according to ie diagnosis criteria (not including a heart murmur) * subjects are current users or have a close history of drug abuse
treatment of non-severe covid-19 outpatients with xagrotin, phase 3

Conditions: Sars-cov-2

Summary: this is an interventional, multi-center, randomized study. adults with confirmed covid-19 disease not more than 10 days before enrollment date will be recruited (n=1000). patients in same condition who get treated with standard of care will be randomly assigned to the control group (n=1000), and patients in same condition who get treated with standard of care will be randomly assigned to the placebo group (n=1000). the investigators analyze the effect of xagrotin, and also investigate impact of different characteristics for instance gender, age, duration of disease, smoking habits and concomitant diseases on the outcome.

an interventional, multi-center, randomized study that will performe in an outpatient setting (n=1000). adults with confirmed covid-19 disease not more than 10 days before enrollment date will be recruited. patients in same condition who had treated with standard of care will randomly assign to the control group (n=1000), and patients in same condition who get treated with standard of care will be randomly assigned to the placebo group (n=1000). the investigators analyze the effect of xagrotin, and also investigate impact of different characteristics for instance gender, age, duration of disease, smoking habits and concomitant diseases on the outcome. adverse events will be registered.

Eligibility criteria:
inclusion criteria: * age 18 or higher * newly diagnosed (no longer than 10 days) * pcr or clinically confirmed covid-19 exclusion criteria: * coronavirus patients admitted to medical centers for hospitalization and receive medical treatment and necessary care in medical centers

Keywords: sars-cov-2
choline fenofibrate and carotid atherosclerosis in patients with type 2 diabetes and combined dyslipidemia

Conditions: Dyslipidemia; Atherosclerosis; Diabetes Mellitus, Type 2

Summary: this is a randomized controlled study to assess the effect of choline fenofibrate compared with policosanol in korean t2dm patients with asymptomatic atherosclerosis.

in patients with type 2 diabetes with atherosclerotic combined dyslipidemia, the effect of choline fenofibrate on the progression of carotid intima media thickness and carotid artery plaque will be evaluated by 3d carotid ultrasound.

Eligibility criteria:
inclusion criteria: * type 2 diabetes under treatment with hba1c 6.0-10.0% at screening visit * male or female of 20 years or over * mixed dyslipidemia: triglyceride 200\~499 mg/dl, hdl-cholesterol male ≤45 mg/dl or female ≤50 mg/dl * identified carotid artery plaque: carotid intima-media thickness (cimt) ≥ 1.0 mm * creatinine ≤1.8 mg/dl exclusion criteria: * dyslipidemia which requires other therapy: triglyceride ≥500 mg/dl or ldl-cholesterol ≥190 mg/dl * uncontrolled hypertension * severe renal dysfunction * got/gpt \>120/120 or chronic liver disease * pregnant or childbearing woman who does not have enough contraception * changes of medication related to chronic diseases (diabetes, hypertension, dyslipidemia, etc.) within 3 months * other antiplatlet medication such as cilostazol, clopidogrel (except aspirin)
diagnostic classifier for cutaneous t-cell lymphomas

Conditions: CTCL/ Mycosis Fungoides

Summary: primary cutaneous t-cell lymphomas (ctcl) are a form of skin cancer that is derived from immune cells. the most common form of ctcl is mycosis fungoides (mf). while initially confined to the skin, mf may spread to lymph nodes, blood or inner organs, resulting in an overall poor prognosis for the patient. thus, being a potentially lethal disease, an early and correct diagnosis of mf has very important implications for the patient. however, diagnosis of early mf is often difficult, as it usually shows a close resemblance to benign inflammatory conditions such as eczema and psoriasis. strikingly, it takes an average of 3-6 (!) years from the appearance of the first skin lesions until a diagnosis of mf can be made. for this reason, a test to distinguishing early mf from benign inflammatory conditions is urgently mandated. by using skin suction blister fluid as well as skin biopsies from patients with mf, eczema and psoriasis, the investigators want to develop a classifier system that can distinguish early mf from benign inflammatory skin diseases.


Eligibility criteria:
inclusion criteria: * clinical and/or histopathological diagnosis of mf, eczema or psoriasis * healthy control subjects without personal history of mf, eczema or psoriasis exclusion criteria: * ongoing skin-targeted treatment (wash out times: 2 weeks for topical, and 4 weeks for systemic treatments) * ongoing other treatment that might, in the opinion of the investigator, influence proteomic features of the samples to be acquired
comparison of bicision® versus ultracision® during laparoscopic supracervical hysterectomy (lash)

Conditions: Uterine Bleeding Disorders; Benign Uterine Conditions; Focus: Comparison of Two Instruments

Summary: the aim of the study is the evaluation of the efficiency and safety of the new, ce-certified thermofu-sion and dissection instrument bicision® in comparison with the long established ultracision® har-monic scalpel(ethicon)during a laparoscopic supracervical hysterectomy (lash).


Eligibility criteria:
inclusion criteria: * age \> 18 * gender: female * indication for laparoscopic supracervical hysterectomy with no adnexectomyor other surgery * will and the capability to comply the study requirements * signed informed consent exclusion criteria: * invasive malignome in the pelvis * cardiac pacemaker or implanted defibrilator if no informations are available about the compatibil-ity with rf energy * abnormal blood parameters (values less than factor 0.8 or more than 1.25 compared to the val-ues of creatinine and standard hemogram) * abnormal coagulation parameters: ptt \> 40 sec. and / or quick's-value\< 50% (the use of antiplateletsup to a max. of 100mg/d is no exclusion criteria) * inability to understand the purpose of the study * status after a laparotomy by a longitudinal incision * intraabdominal adhesions (at the beginning of the surgery ≥ 5 sectioning for adhesiolysis) * open laparoscopy required * different anatomical situations that yields to different surgery requirements * conspicuous pap, cervixmyoma or endometriosis of the rectovaginale space

Keywords: supracervical hysterectomy vessel sealing bipolar electrocoagulation
supported employment and skills training in conjunction with pharmacotherapy in schizophrenia patients

Conditions: Schizophrenia

Summary: this study will compare employment support with behavioral skills training to employment support alone in schizophrenia patients taking either risperidone or olanzapine to determine which is more effective in helping the patients maintain a job.

schizophrenia is a severe mental disorder characterized by disorganized thoughts, difficulty concentrating, and hallucinations. individuals with schizophrenia often experience reduced emotional, social, and occupational functioning. data indicate that antipsychotic drug treatment and occupational training and support may be effective in helping people with schizophrenia maintain a stable job. risperidone and olanzapine are antipsychotic drugs; participants in this study will be taking either risperidone or olanzapine for the duration of the study. this study will provide schizophrenia patients with employment support alone or with behavioral skills training to determine which combination is more effective in helping patients obtain and maintain a job. at study entry, participants will undergo a clinical and diagnostic evaluation to determine the severity of their schizophrenia. participants will be tapered off their regular medication for schizophrenia over 4 weeks. at the end of week 4, they will be randomly assigned to receive either risperidone or olanzapine. participants will then be assigned an individual placement and support (ips) specialist to assist them in finding a job. after participants secure a job, they will be randomly assigned to receive ips either alone or with the workplace fundamentals skills training module for 2 years. participants' risperidone or olanzapine treatment will continue during this 2-year period. participants will have clinic visits at study entry and months 7, 12, and 24. at each visit, participants will complete questionnaires and will be interviewed about their schizophrenia symptoms and occupational functioning.

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia * candidate for maintenance schizophrenia treatment * willing to initiate and continue risperidone or olanzapine therapy for the duration of the study exclusion criteria: * any serious medical problems other than schizophrenia that would interfere with the study

Keywords: antipsychotic agents employment
tca cycle in the dentate in friedreich's ataxia

Conditions: Friedreich Ataxia

Summary: objective: to measure the tricarboxylic acid (tca) cycle rate in the dentate nucleus in a group of control subjects and subjects with friedreich's ataxia (frda). hypothesis: the tca cycle rate will be lower in frda subjects than in controls approach: the investigators will infuse carbon-13 (13c) labeled glucose and measure the rate of 13c label incorporation from glucose to glutamate in the brain using in vivo magnetic resonance spectroscopy.

the investigators will measure the tca cycle rate in the dentate nucleus in a group of frda patients and in a group of age-matched healthy controls using 13c mrs in vivo together with systemic i.v. infusion of 13c-labeled glucose. the investigators aim to obtain adequate data in 16 subjects grouped as follows: * n=4 pilot subjects (healthy subjects) for testing and optimization of the experimental setup. * n=6 healthy controls * n=6 frda patients in other to reach this goal, the investigators plan to recruit up to 20 subjects, in case some subjects withdraw before completion of the mr scan, or in case the measured data are not adequate (e.g. technical problem with the scanner).

Eligibility criteria:
inclusion criteria: * 18 years of age or older * able to consent for themselves * considered healthy (controls) or be diagnosed with frda. exclusion criteria: * all subjects: * participants who cannot have an mri, as determined by the cmrr safety screening form (e.g. metal implant) * pregnancy * clautrophobia * diabetes * clinically significant cardiac disease control subjects: - neurological disease
prevention of post-traumatic stress disorder in soldiers

Conditions: Post-traumatic Stress Disorder (PTSD); Aggressive Behavior

Summary: soldiers in conflict or former conflict regions deployed in peace-keeping missions were and are often exposed to multiple traumatic events and situations in which they are forced to engage in violent behavior. the preventive narrative exposure therapy (pre-net) aims to reinforce resilience thereby reducing the risk of developing or aggravating ptsd or other mental disorders as a result of traumatic experiences. the effective prevention of mental disorders as a result of war deployment is expected to facilitate reintegration in civil life after deployment and reduce uncontrolled violence.


Eligibility criteria:
inclusion criteria: * exposure to traumatic experiences derived from expert interviews with scores of the traumatic life event list for war and torture * soldiers are part of the burundian army and of the joint african union and united nations peacekeeping mission in somalia (amisom) exclusion criteria: * current use of mind altering drugs * psychotic symptoms

Keywords: post-traumatic stress disorder (ptsd) aggressive behavior appetitive aggression resilience preventive narrative exposure therapy
effect of hepatectomy on the prognosis of patients with nasopharyngeal carcinoma liver metastases

Conditions: Nasopharyngeal Carcinoma; Liver Metastases

Summary: the goal of this clinical trial is to learn about hepatectomy on the prognosis of patients with nasopharyngeal carcinoma liver metastases (nclm). the main questions it aims to answer are: to explore the effect of hepatectomy on the overall survival, recurrence-free survival and other prognostic indicators of patients with nclm. to explore the impact of hepatectomy on the safety of patients with nclm. researchers will compare the prognosis of the patients in the hepatectomy group and the patients with nclm who were prospectively enrolled in the same institution and received only systemic treatment at the same time by propensity score matching.


Eligibility criteria:
inclusion criteria: * nasopharyngeal carcinoma liver metastases (nclm) are diagnosed by pathological confirmation of liver biopsy or imaging findings combined with clinical history. * ecog score ≤ 2 points. * 1. patients with no recurrence of the primary tumor and oligometastasis in the liver. 2. patients with multiple metastases (bone) without primary tumor recurrence and liver metastases have stable disease (sd) or partial remission (pr) or complete remission (cr) after systemic treatment except for liver lesions. 3. patients with primary tumor recurrence and liver metastasis (may be combined with bone metastasis) have sd or pr or cr after systemic treatment except for liver lesions. * able to perform radical resection of liver lesions. * good liver function (child-pugh grade a liver function, estimated remaining liver volume ≥ 30%). * blood test, coagulation function, liver and kidney function, electrocardiogram, chest x-ray and other preoperative examinations show no clear contraindications for surgery. * expected survival ≥ 6 months. * those who voluntarily participate in this study and signe the informed consent form. exclusion criteria: * younger than 18 or older than 70 years old. * ecog score \> 2 points. * combined with distant metastasis other than liver and bone. * disease progression (pd) after systemic treatment of the primary tumor and bone metastases. * the liver lesion cannot be resected by r0. * insufficient liver reserve function (preoperative liver function child-pugh b or c grade and cannot be reduced to a grade in a short time, or estimated remaining liver volume \<30%). * combined with surgical contraindications in the preoperative examination, such as cardiac clinical symptoms or diseases that are not well controlled, abnormal coagulation function with bleeding tendency, or receiving thrombolytic therapy, etc.. * liver metastases have received local treatment for liver metastases such as interventional and radiofrequency. * pregnant or lactating women. * history of malignant tumors in other parts, severe mental illness, etc.. * patients or family members cannot understand the conditions and objectives of this study.

Keywords: nasopharyngeal carcinoma liver metastases hepatectomy prognosis