Kornimate/medical-research-clean huggingface dataset:
stimulating catheter with or without ultrasound guidance

Conditions: Pain

Summary: to study whether the combination of ultrasound guidance and stimulating catheter could reduce the time for needle and catheter insertion compared with using stimulating catheter alone. secondary outcomes: analgesic effects after the surgery.


Eligibility criteria:
inclusion criteria: * elective primary total knee replacement surgery under neuraxial anesthesia asa\<=4 * able to give informed consent * able to cooperate with sensory and motor testing of lower limb function exclusion criteria: * coagulopathy * allergy to local anaesthetic or postanalgesic rescue regimen * signs, symptoms or laboratory evidence of local infection or systemic sepsis * no pre-existing neurological deficit (sensory or motor) affecting lower limb * patients with lower limb amputations
the relationship between inflammatory artritis and cardiac disease

Conditions: Inflammatory Arthritis; Rheumatoid Arthritis; Spondylitis, Ankylosing; Axial Spondyloarthritis; Spondyloarthritis; Heart Failure; Ischemic Heart Disease; Valvular Heart Disease; Left Ventricular Systolic Dysfunction; Heart Failure, Systolic; Heart Failure, Diastolic; Myocardial Infarction; Myocardial Dysfunction; Cardiac Disease; Stroke

Summary: the goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to collectively as inflammatory arthritis (ia). the main questions it aims to answer are: * using conventional echocardiography, the investigators aim to determine the prevalence of overt and asymptomatic cardiac dysfunction in a large random sample of outpatients with ia. cardiac dysfunction will be evaluated by echocardiography and cardiac biomarkers (nt-pro-bnp, hs-tnt and hs-crp). * in patients without known heart disease: using 2, 5 and 10 year follow-up, the investigators aim to examine if advanced echocardiography can be used to detect early signs of heart disease by investigating the clinical significance of adding deformation measures - alone and in combination with selected biomarkers - to conventional risk factors in the cardiac risk assessment of patients with ia participants will undergo an echocardiographic examination in combination with a general health assessment including obtainment of cardiac biomarkers and a electrocardiogram. using advanced echocardiography - tissue doppler imaging, 2- dimensional speckle tracking echocardiography, 3d-echocardiography and 3-dimensional speckle tracking echocardiography - the investigators also aim to compare myocardial deformation parameters of patients with ia to a gender and age matched control group without ia from the copenhagen city heart study.


Eligibility criteria:
inclusion criteria: * persons with a diagnosis of with a confirmed diagnosis of rheumatoid arthritis or axial spondyloarthritis exclusion criteria: * persons not able to cooperate * persons unable understand and sign "informed consent"
rwe about qol and compliance of patients with ofs in china

Conditions: Breast Cancer; Quality of Life; Hormone Receptor-positive Breast Cancer

Summary: the purpose of this study is to assess the patient's feedback from using gnrha depot formulation in postoperative, premenopausal patients with hormone receptor-positive breast cancer.

this was a real world, observational study of adjuvant therapy with gnrha for ofs in postoperative, premenopausal women with endocrine responsive breast cancer. this trial is designed to compare patients' qol and treatment compliance measured by fact-b and self-administered questionnaires during ofs treatment period. total score of fact-b and self-administered questionaries, and change from baseline will be calculated and summarized descriptively. change from baseline will be compared between gnrha 3-month and gnrha 1-month using ancova model with baseline value as a covariate.the number depends on the patients who received questionnaire during 18 months recruitment in planned 10 sites. this analytical plan assumes homogeneity across 10 sites so that strata is not considered.

Eligibility criteria:
inclusion criteria: age≥18 years old; both or either er+ or pgr+ primary tumor; t1-t3, any n, and m0 according to the tnm classification; any type of breast surgery (includes breast conserving surgery and breast cancer radical surgery); any type of preoperative and/or postoperative adjuvant chemotherapy prior to enrollment; history of regular menstruation and not having chemical menopause (fsh≥40 miu/ml and e2\<10 pg/ml) within 12 weeks after completion of the postoperative chemotherapy; previously using gnrh-a 1m or 3m as ofs treatment for at least one time; capable of receiving other study drug like tamoxifen or ai; eastern cooperative oncology group performance status of grade 0 or 1. exclusion criteria: uncapable of receiving endocrine therapy for any clinical or other reason; bilateral oophorectomy or ovarian irradiation inflammatory breast cancer or bilateral breast cancer; multiple cancers or a history of cancer in other organs; patients with other non-malignant systemic diseases (cardiovascular, renal, hepatic, lung, etc.) that would prevent prolonged follow-up.

Keywords: gnrha patient-reported qol treatment compliance
the effect of therapeutic methods for chronic knee osteoarthritis pain

Conditions: Osteoarthritis, Knee

Summary: chronic osteoarthritis (oa) pain of the knee is not effectively abrogated by the available non-pharmacologic or pharmacologic treatments. radiofrequency (rf) neurotomy is a therapeutic alternative for chronic pain. here, the researchers investigate the efficacy of rf neurotomy applied to articular branches (genicular nerves) in treating knee joint pain.

the knee joint is innervated by articular branches of various nerves (femoral, common peroneal, saphenous, tibial and obturator) (kennedy et al. 1982; hirasawa et al. 2000). these articular branches around the knee joint are known as genicular nerves. several genicular nerves can be easily approached percutaneously under fluoroscopic guidance. in our study, genicular nerves were effectively blocked with local anesthetics under fluoroscopic guidance, leading to a significant reduction in knee pain. rf neurotomy is based on the theory that cutting the nerve supply to a painful structure may alleviate pain and restore function. we evaluate the efficacy of rf neurotomy in reducing pain and improving function in the elderly with chronic knee oa.

Eligibility criteria:
inclusion criteria: * patients with chronic knee pain (i.e., knee pain of moderate intensity or greater on most or all days for ≥ 3 months) * patients with radiologic knee osteoarthritis (kellgren-lawrence grade 2-4, evaluated by a radiologist) exclusion criteria: * acute knee pain * prior knee surgery * other connective tissue diseases affecting the knee * serious neurologic or psychiatric disorders * injection with steroids or hyaluronic acids during the previous 3 months * sciatic pain * anticoagulant medications * pacemakers * prior electroacupuncture treatments

Keywords: genicular nerve osteoarthritis knee neurotomy
vitamin b12 vs b3 for nerve regeneration and functional recovery after pediatric traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: a traumatic brain injury (tbi) is among the most frequent reasons for neurological impairment in young people. the investigators investigated whether vitamin b12 vs b3 therapy could reduce the severity of traumatic brain injury (tbi) due to their positive effects on axon regrowth following nerve damage. the method utilized was a series of non-random samples. with a 95% confidence interval and a 5% margin of error, a total sample of 300 patients was estimated using epi info. participants in our study comprised both boys and girls with severe tbi ages 6 to 15 years old. two groups of 300 children were recruited. b3 (16 mg/day) was administered to group 1 and b12 (125-250 mcg/day) was provided to group 2. it is evaluated through follow-ups on a range of tests to evaluate cognitive capacity, sensorimotor activity and staircase test (working and reference memory). pre-and post-treatment gcs measurements were conducted. three weeks and a year following the treatment of tbi, children underwent neurobehavioral testing. the measurement of gait analysis was done. the standard error and mean of statistically examined data were shown by paired t-test.

a traumatic brain injury (tbi) is among the most frequent reasons for neurological impairment in young people. the investigators investigated whether vitamin b12 vs b3 therapy could reduce the severity of traumatic brain injury (tbi) due to their positive effects on axon regrowth following nerve damage. the method utilized was a series of non-random samples. with a 95% confidence interval and a 5% margin of error, a total sample of 300 patients was estimated using epi info. participants in our study comprised both boys and girls with severe tbi ages 6 to 15 years old. two groups of 300 children were recruited. b3 (16 mg/day) was administered to group 1 and b12 (125-250 mcg/day) was provided to group 2. it is evaluated through follow-ups on a range of tests to evaluate cognitive capacity, sensorimotor activity and staircase test (working and reference memory). pre-and post-treatment gcs measurements were conducted. three weeks and a year following the treatment of tbi, children underwent neurobehavioral testing. the measurement of gait analysis was done. the standard error and mean of statistically examined data were shown by paired t-test.

Eligibility criteria:
inclusion criteria: * children aged 6 to 15 years old * children with severe tbi of * children of both genders exclusion criteria: * those with mild injury * stable glasgow coma scale * not willing to consent
binaural sound for remimazolam induction

Conditions: General Anesthesia; Prostate Cancer; Uterine Myoma

Summary: it is important to decrease the time-to-loss of consciousness and anesthetics dose of remimazolam for general anesthesia induction. we will evaluate the effect of binaural sound for general anestheia induction using remimazolam infusion.


Eligibility criteria:
inclusion criteria: 1. patients scheduled for generla anesthesia 2. patients aged 20-60 3. patients with american society of anesthesiologist physical status classification 1-2 4. patients with ideal body weight 50-80 kg exclusion criteria: 1. patients with hearing disability 2. patients using opioids or sedatives in 1 week 3. patients who are dependent for alcoholics or drugs 4. patients with hypersensitivities to remimazolam 5. patients with arrhythmia, cardiovascular disease, heart failure, or hypovolemia 6. patients with liver failure
ventral hernia improvement of treatment and life

Conditions: Incisional Hernia; Parastomal Hernia; Ventral Hernia

Summary: the goal of this clinical trial called the vital study is to learn if surgery has a positive impact on the quality of life in patients with incisional or parastomal hernia. the main questions it aims to answer are: does surgery alleviate patients from their initial problem? does new discomfort arise after surgery? do the symptoms worsen, and does quality of life deteriorate in patients who are not offered surgery? the project will also look at time to surgery and postoperative complications. researchers will send questionnaires to the patients to answer. participants will: answer the baseline questionnaire. answer the follow-up questionnaires at 1 month, 3 months, 6 months, 1 year, and 3 years after surgery or after the baseline questionnaire has been completed for those patients being managed conservatively with observation


Eligibility criteria:
inclusion criteria: * \>18 years * incisional hernia or parastomal hernia exclusion criteria: - can't understand or read danish

Keywords: incisional hernia parastomal hernia quality of life patient-reported outcomes
hypothalamic amenorrhea as a fertility status marker for cardiovascular health (arch)

Conditions: Hypothalamic Amenorrhea

Summary: hypothalamic amenorrhea (ha) occurs during reproductive years and results in stopped menstrual cycles and infertility which can be prolonged from months to years and is characterized by varying combinations of psychosocial stress, anxiety, high levels of physical activity, and/or weight loss. data from our group indicates that one-third of women with ha (mean age: 27 yrs) have preclinical cardiovascular disease (cvd) measured noninvasively as vascular dysfunction and vascular inflammation. this study will use ha as a marker of fertility status for cardiovascular health and perform dense-phenotyping using remote patient monitoring (fitbit) and patient reported outcomes (questionnaires) to determine which ha phenotypes are related to preclinical cvd and inflammation.


Eligibility criteria:
inclusion criteria: * secondary amenorrhea of 3 or more consecutive months duration * include the screening hormones (eg, estradiol (e2) \< 50 pg/ml, follicle-stimulating hormone (fsh) \<10 miu/ml, and luteinizing hormone (lh) \< 10miu/ml and other ha-defining hormones); or clinical diagnosis of ha by medical providers. * pre-menopause status. * able to give informed consent. exclusion criteria: * a diagnosis for secondary amenorrhea including prolactinoma, polycystic ovary syndrome (pcos), premature ovarian insufficiency, pituitary surgery, infection or infarction * pregnancy * psychotropic/illicit drug use * mental/neurological/major psychological disorders (other than depression and anxiety). * parturition/lactating in the last 6-12 months.

Keywords: functional hypothalamic amenorrhea amenorrhea
mood disorders bladder cancer

Conditions: Bladder Cancer

Summary: this is a cross-sectional study evaluating mood disorders in bladder cancer patients and their caregivers across the bladder cancer trajectory


Eligibility criteria:
inclusion criteria: * patients or caregiver of patient with a histologic diagnosis of bladder cancer of the following subtypes, urothelial carcinoma, adenocarcinoma, or squamous cell carcinoma, within 24 months of survey administration and received treatment at the university of kansas health system * ≥ 18 years of age * have a patient-designated primary informal/family caregiver * able to speak and read english * willing and able to provide informed consent * functioning telephone number or access to one exclusion criteria: * patients or caregivers of patients with metastatic bladder cancer * patients who are unable to designate a primary caregiver * patients and caregivers who do not both consent to study participation
to compare the safety and efficacy of intracameral levofloxacin and intracameral cefazolin in reducing rates of endophthalmitis following cataract surgery.

Conditions: Cataract

Summary: patients with senile cataracts undergoing phacoemulsification were assigned to receive intracameral levofloxacin (0.1ml/0.5mg) or intracameral cefazolin (0.1ml/1mg). the primary endpoint was the occurrence of endophthalmitis during the 3 month follow-up period. secondary endpoints included best-corrected visual acuity (bvca), the presence of anterior chamber (ac) inflammation with grading of ac cells and presence of flare, along with intraocular pressure (iop), corneal cell thickness (cct), central foveal thickness (cft) and cell density.


Eligibility criteria:
inclusion criteria: * aged ≥50 to \<80 years * undergoing cataract surgery under the care of one of three study investigators, all of whom were consultant level cataract surgeons * only those with senile cataracts, assessed using the lens opacities classification system iii scale (locs iii) and without features of complex cataracts were included exclusion criteria: * \ 80 years old * prior ocular trauma, pregnant, previous history of refractive, corneal or intraocular surgery, cornea endothelial cell count \<1500/sqmm², concomitant ocular disease, allergy to penicillin, fluoroquinolone or cephalosporin, and abnormal biometric measurements
evaluate effects of personalized patient counselling for enbrel® therapy in adults with rheumatoid arthritis

Conditions: Persistence to Enbrel

Summary: this study will evaluate whether the effect of personalized patient counselling tool, information-motivation-strategy (ims) based on the results of the beliefs about medicines questionnaire (bmq) will improve persistence of enbrel (etanercept) therapy at week 52 in subjects with rheumatoid arthritis over the historical control as estimated by the standard of care.


Eligibility criteria:
inclusion criteria: * subject has provided informed consent prior to any study specific procedures * diagnosed with rheumatoid arthritis and eligible for treatment with enbrel® (etanercept) * subject has been prescribed and has access to commercial enbrel® (etanercept) (50mg once weekly) according to the subject's health insurance * completion of all required safety assessments before starting treatment with enbrel® (etanercept) other inclusion criteria may apply. exclusion criteria: * previously received treatment with a biologic disease modifying antirheumatic drug (dmard) and/or tofacitinib. * malignancy (except nonmelanoma skin cancers, cervical or breast ductal carcinoma in situ) within the last 5 years * refusal to consent to enroll in the enliven program * currently receiving treatment in another investigational device or drug study, or less than 30 days since ending treatment on another investigational device or drug study(s) other exclusion criteria may apply.

Keywords: enbrel rheumatoid arthritis
isis 1 therapeutic effectiveness

Conditions: OSAS (Obstructive Sleep Apneas Syndrome)

Summary: the study is a prospective field evaluation to assess the therapeutic value of the cpap/autocpap sandman in 24 new diagnosed obstructive sleep apneic patients. precisely, the study was designed to : * evaluate the therapeutic efficacy of the cpap/autocpap sandman device in improving sleep quality and normalozing respiratory events * determine the sensitivity and specificity of the device in adequately detecting respiratroy events * compare effective pressure peff determined by the device and during manual titration * compare the impact of the two-speed descent pressure algorithm

during the study, each patient underwent one night of full polysomnography with two consecutives therapeutic sequences during the same night, after randomization of the passage order: * autotitrating pressure phase: sleep parameters and respiratory events vs results of the polysomnographic registration, * manual titration phase: concordance between events respiratory analyzed on the polysomnographic recordings and the events detected by the cpap / auto-cpap.

Eligibility criteria:
inclusion criteria: * patient male or female, aged 18 to 75 years * weight \> 30kg * patient with a newly diagnosed osas, under treatment with cpap * patient in stable condition * patient affiliated to a social security insurance * having given its written informed consent to participate to the study exclusion criteria: * pneumothorax or pneumomediastin history * massive epistaxis (current or previous) * decompensated heart failure or hypotension * pneumoencephal history, recent trauma or surgery sequel with cranio-nasopharyngeal fistula * acute sinusitis history, middle ear infection or perforation of the tympanic membrane * respiratory insufficiency or severe respiratory illness with the possibility of residual hypoxemia * severe bullous emphysema or previously complicated pneumothorax * severe claustrophobia
yoga for persons with severe visual impairment

Conditions: Sleep Disturbance; Stress; Anxiety; Depression; Balance Impairment

Summary: this study aims to provide novel information on the feasibility of yoga interventions for secondary symptoms related to severe vision loss, such as sleep disturbances, negative mood states, fall risk and balance. this information will be important for determining safe, cost-effective and reliable practices for the benefits of yoga as an alternative means for improved health and well-being. a yoga intervention that is integrative and evidence-based will benefit the blind population through effective treatments and prevention of secondary symptoms as well as serve to inform rehabilitation specialists, educators, and clinicians in the future.

this study aims to provide novel information on the feasibility of yoga interventions for secondary symptoms related to severe vision loss, such as sleep disturbances, negative mood states, fall risk and balance. this information will be important for determining safe, cost-effective and reliable practices for the benefits of yoga as an alternative means for improved health and well-being. a yoga intervention that is integrative and evidence-based will benefit the blind population through effective treatments and prevention of secondary symptoms as well as serve to inform rehabilitation specialists, educators, and clinicians in the future.

Eligibility criteria:
inclusion criteria: * age 18+ * legal blindness (visual acuity worse than 20/200 but better than no/bare light perception, and/or visual field less than 20º, in the better eye) * any ocular disease diagnosis that is expected to remain relatively stable throughout a 3-6 month period * being healthy to the extent that participation yoga therapy would not exacerbate any existing disease conditions; * willingness to participate on a weekly basis for the 12-week intervention; * moderate to severe sleep disturbances, defined as ratings of 5 or greater on the psqi exclusion criteria: * significant changes to vision within the most recent 3-month period * inability to understand study procedures or communicate responses to visual stimuli in a consistent manner * clinically diagnosed or clinically significant sleep disorder (e.g., sleep apnea) or a medical or psychiatric condition (e.g., chronic pain) responsible for sleep complaints; * use of prescription sleep medication more than once a week for duration of the study; * use of other psychotropic medication; * current recipient of sleep disorder treatment; * consumption of more than 2-3 alcoholic beverages per day * smoking more than 10 cigarettes per day;