Kornimate/medical-research-clean huggingface dataset:
comparing pcct with ica and ivus in detecting cardiac allograft vasculopathy

Conditions: Cardiac Allograft Vasculopathy

Summary: in traditional coronary artery disease, patients often experience symptoms such as angina. however, heart transplant patients lack nerve connections in the transplanted heart and therefore usually do not notice any symptoms. for this reason, routine examinations are performed using traditional coronary angiography at one, three, and six years after transplantation, sometimes with the addition of coronary ultrasound. a new technique, photon-counting computed tomography, has now been developed and may potentially replace both traditional coronary angiography and intravascular ultrasound. in this study, we aim to investigate how well this method works in diagnosing coronary artery changes compared to the established methods.

cardiac allograft vasculopathy (cav) is a major cause of graft failure and mortality in heart transplant recipients. unlike traditional atherosclerosis, cav is characterized by diffuse intimal hyperplasia and concentric narrowing of coronary arteries, affecting both epicardial vessels and the microvasculature. the cause is largely unknown, although it is believed that both immunologic and non-immunologic factors could be at play. cav is frequently asymptomatic due to denervation of the transplanted heart, underscoring the importance of routine surveillance to enable early and accurate detection. such monitoring is essential to optimize post-transplant outcomes. invasive coronary angiography (ica) is the gold standard for diagnosing cav, while intravascular ultrasound (ivus) can be considered as the gold standard for the assessment of intimal thickening and plaque burden. photon-counting computed tomography (pcct) represents a novel, non-invasive imaging modality with superior spatial resolution and tissue contrast compared to conventional ct systems. a systematic comparison of pcct with ica and ivus for detecting cav has not yet been performed. this study aims to assess the diagnostic accuracy, clinical relevance, and cost-effectiveness of pcct in comparison to ica and ivus. by evaluating the advantages and limitations of non-invasive versus invasive modalities, the study seeks to define the optimal surveillance strategy for cav, ultimately guiding the management of heart transplant recipients and improving long-term outcomes.

Eligibility criteria:
inclusion criteria: * adult heart transplant recipients. * clinically stable and scheduled for routine ica. * ability to provide informed consent exclusion criteria: * contrast allergy * renal insufficiency with egfr \< 30 ml/min/m2 * other contraindications for pcct, ica, or ivus * acute cardiac events within 30 days prior to enrollment.

Keywords: heart transplantation cardiac allograft vasculopathy photon counting computed tomography invasive coronary angiography intravascular ultrasound
first-in-human dose-escalation study of stp1002 in patients with advanced-stage solid tumors

Conditions: Advanced Solid Tumor

Summary: this is an open-label, multicenter, dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics (pk) and to determine the maximum tolerated dose (mtd) of stp1002 in patients with advanced-stage solid tumors.


Eligibility criteria:
inclusion criteria: * advanced-stage solid tumor (metastatic or locally advanced and unresectable) with histologically confirmed diagnosis of crc, nsclc, gc, rcc, or hcc * measurable lesion(s) according to recist 1.1 criteria * performance status of ≤ 2 on the eastern cooperative oncology group (ecog) scale. * ability to swallow capsules * received last chemotherapy, biologic, or investigational therapy at least 4 weeks prior to first dosing of study treatment * has received or is intolerant to all standard of care treatment options with known clinical benefit * life expectancy of more than 3 months * adequate hematological, hepatic and renal function * for women of childbearing potential, a negative serum pregnancy test performed within 7 days prior to start of treatment exclusion criteria: * received treatment within the last 28 days with a drug that has not received regulatory approval for any indication at the time of study entry * major surgery within the last 28 days prior to the first dose of investigational drug * prior radiation therapy within 14 days prior to study cycle 1 day 1 and/or persistence of radiation-related adverse effects. * concurrent treatment with any anticancer agent * currently taking either strong cyp inhibitors or inducers * known brain metastases, uncontrolled seizure disorder, or active neurologic disease * significant cardiovascular impairment * pregnant or nursing * known hiv infection, active hepatitis c and/or hepatitis b infection * known bleeding disorder or coagulopathy * active drug or alcohol abuse or history of alcohol or drug abuse during the last two years. * diagnosis of osteoporosis at the time of the screening * any history of retinal pathology including diabetic retinopathy, macular degeneration, or other retinal degenerative disease
student outcomes in fitness and nutrition iseo

Conditions: Obesity

Summary: the study is designed to examine whether curriculum, designed in partnership with teachers at moreland elementary school in west st. paul and mayo clinic inscied out scientists, is able to influence the behavior and health literacy of students. this information will be collected in surveys before and after the students are given the curriculum during the school day.

the research will implement a short battery of two survey inventories to measure student outcomes under inscied out fitness and nutrition curriculum that is currently administered in 3rd and 4th grade at lincoln k-8 choice school. one is a grade-level adapted version of the national youth physical activity and nutrition survey (nypans) authored by the united states center for disease control (cdc). the other is a grade-level adapted version of the newest vital sign (nvs) health literacy assessment authored by pfizer and adapted by dr. linda aldoory at the university of maryland. these assessments will help inform the health promotion activities of the inscied out partnership within lincoln k-8 choice in rochester, minnesota (mn) and moreland elementary in west st. paul, mn who originally wrote the curriculum. these assessments will be key to curricular revision and expansion to other schools that partner with inscied out. as such, this study is a single cohort, internally controlled pre-post assessment of an existing behavioral intervention. pending pilot study success, future follow-up studies are projected to be parallel-group, nonrandomized clinical trials of a treatment school versus a control school with grade levels expansion. this study will inform activities within the inscied out network inside rochester public schools (rps), where grades kindergarten through 2nd and 5th through 8th curricula is currently being built. previously rps-approved mayo clinic institutional review board (irb) #13-003263 describes the format of inscied out programming in detail, but the general framework of this study operates upon an established partnership between inscied out researchers and lincoln k-8 choice/moreland elementary administrators, teachers, students, and parents. irb#13-003263 describes the format of inscied out programming in detail, but the general framework of this study operates upon an established partnership between inscied out researchers and administration, teachers, and students at lincoln k-8 choice elementary.

Eligibility criteria:
inclusion criteria: * students attending 3rd and 4th grade classes at lincoln k-8 choice elementary school in rochester, mn or moreland elementary school in west st. paul, mn who assent to the study exclusion criteria: * students attending 3rd and 4th grade classes at lincoln k-8 choice elementary school in rochester, mn or moreland elementary school in west st. paul, mn whose parents chose to opt-out of the study or who do not assent to the study

Keywords: program evaluation health literacy fitness nutrition education
evaluation of compulsive exercise group therapy for eating disorders

Conditions: Eating Disorders in Adolescence

Summary: the study aims to generate hypotheses about whether a group intervention is effective in reducing motivation to compulsive exercise and/or eating disorder psychopathology when compared with a control group. this will be explored through a randomized control trial.


Eligibility criteria:
inclusion criteria: * inpatients at newbridge house * aged 11-18 * primary diagnosis of any form of eating disorder * females exclusion criteria: * previously received neat group at newbridge house * aged under 10 years * severe learning disability * inpatients without compulsive exercise behaviours * day patients * co-morbid psychosis * males
does addition of a vessel loop in wound closure improve suture removal?

Conditions: Patient Satisfaction; Suture, Complication

Summary: this study will investigate whether adding a vessel loop under sutures after elective carpal tunnel release increases patient satisfaction with suture removal.

surgical wound closure with nonabsorbable stitches necessitates subsequent suture removal, a process that can be uncomfortable for the patient and consume clinic time and resources. anecdotal evidence suggests that the addition of a vessel loop under the sutures both simplifies suture removal and reduces discomfort. in this study, we propose a prospective, randomized, controlled, superiority trial to assess the impact of a vessel loop wound closure and suture removal for elective carpal tunnel release (ctr). patients will be prospectively enrolled to one of two groups: closure without a vessel loop or closure with a vessel loop. the primary outcome measure will be patient satisfaction with suture removal. time for wound closure, time for suture removal, pain with suture removal and other patient reported outcomes will be measured. these data will allow us to determine the benefit of addition of a vessel loop in wound closure.

Eligibility criteria:
inclusion criteria: * patients undergoing elective primary ctr (cpt 64721) at carilion clinic for carpal tunnel syndrome (cts) diagnosed by cts-6 or electrodiagnostic studies (eds). exclusion criteria: * emergency procedures. * revision procedures. * bilateral procedures. * concomitant procedures. * inability to provide informed consent for the study. * non-native english speakers. * allergy to suture material. * history of wrist trauma.

Keywords: suture vessel loop suture removal satisfaction carpal tunnel release
intensive uric acid lowering with verinurad and febuxostat in patients with albuminuria

Conditions: Hyperuricemia; Albuminuria; Type 2 Diabetes

Summary: the purpose of this clinical research study is to evaluate signals of potential clinical benefit of the combination of verinurad and febuxostat in lowering concentrations of circulating uric acid and thus improving kidney or cardiovascular status of patients with hyperuricemia, albuminuria, and type 2 diabetes (t2dm).

evidence shows independent associations between elevated serum uric acid (sua) and the risk of hypertension, myocardial infarction (mi), chronic kidney disease (ckd), t2dm, heart failure (hf), and metabolic syndrome, including obesity. gout is associated with an increased risk of all-cause death, as well as cardiovascular death. the causal relationship between elevated sua, gout, and these disease outcomes remains to be proven. verinurad (rdea3170), is a novel urate transporter 1 (urat1) inhibitor in phase ii development. verinurad combined with the xanthine oxidase (xo) inhibitor febuxostat has been shown to lower sua in patients with recurrent gout in phase ii studies by \>80%. the extensive lowering of sua delivered by the combination presents a unique opportunity to explore whether intensive urate lowering therapy can improve kidney and/or cardiac health. this study will assess if intensive serum urate lowering therapy, more potent than ever explored before in the chronic out-patient setting, can improve chronic kidney or cardiac function in the study population. in order to maximize the scientific value of the study and minimize the risk for systemic biases a parallel group, double blind, randomized design will be utilized. the study will recruit patients with hyperuricemia and presenting with albuminuria. hyperuricemic patients are expected to benefit more from urate lowering, and albuminuria at baseline is required, as the primary objective of the study will be to assess changes in albuminuria. patients are also required to be diagnosed with t2dm. patients with t2dm frequently exhibit changes in cardiac function detectable using magnetic resonance imaging (mri) that represents an early, pre-symptomatic state of hf. by limiting recruitment to patients with t2dm and by performing mri at baseline and 6 months of therapy, the study will deliver insights into whether or not intensive urate lowering therapy can positively affect not only chronic kidney disease, but also cardiac disease.

Eligibility criteria:
inclusion criteria: * serum uric acid ≥6.0 mg/dl * egfr ≥30 ml/min/1.73 m2 * uacr between 30 mg/g and 3500 mg/g inclusive * diagnosed with t2dm exclusion criteria: * treated with any drug for hyperuricemia in the 6 months preceding randomization.drugs for hyperuricemia include all xo inhibitors (allopurinol, febuxostat and topiroxostat) and urat1 inhibitors (lesinurad, verinurad, probenecid, and benzbromarone) * prior history of gout, unless prophylaxis therapy isn't required * patients who are pregnant, lactating, or planning to become pregnant * patients unsuitable or unable to undergo mri assessment
beetroot juice ingestion effects on field hockey performance.

Conditions: Nitrates; Hockey

Summary: scientific evidence supports that only a few dietary supplements have reported good evidence for improving sports performance, between we can mention beetroot juice supplementation with doses \> 5 mmol of no3-. in this randomized placebo-controlled study, we investigated the effects of bj acute supplementation in improving neuromuscular performance and match-play demands in female field hockey players.

beetroot juice supplementation has demonstrated good evidence for improving sports performance, however, benefits in team sports, especially in female athletes, are underrepresented. in this randomized placebo-controlled study, we investigated the effects of beetroot juice acute supplementation in improving neuromuscular performance and match-play demands.testing sessions will comprise a neuromuscular test battery consisting of a countermovement jump (cmj), isometric handgrip strength, 20-m sprint and repeated sprint ability test, followed by a 20-minute simulated field hockey physical match activity (distances, speeds, accelerations and decelerations) will be monitored in real-time using an inertial tracking system

Eligibility criteria:
inclusion criteria: * elite female field hockey players (playing in first field hockey division). * more than 8 years of field hockey training experience. exclusion criteria: * concurrently participating in other studies. * contraindications associated to beetroot ingestion. * health problems or musculoskeletal injuries 6 months previous to study realization

Keywords: dietary supplements sports nutrition field hockey female
identifying risk factors for developing aki in sepsis

Conditions: Sepsis; Acute Kidney Injury; Diabetic Ketoacidosis

Summary: a study to evaluate the prevalence of acute kidney injury (aki) in patients with diabetic ketoacidosis (dka) and sepsis using data collected prospectively to a patient registry. the primary objective is to compare the prevalence of aki in sepsis and dka in different age groups in children and investigate the difference in the prevalence of hyperchloremia in the two groups.secondary objectives are compare the prevalence of aki in sepsis and dka in different age groups in children and investigate the difference in the prevalence of hyperchloremia in the two groups.

it is a descriptive study to report the prevalence ofacute kidney injury ( aki) in the two cohorts of sepsis and diabetic ketoacidosis ( dka). in addition we aim to evaluate the relation with hyperchloremia. in both groups, attempts will be made to evaluate the association of risk factors such as severity of dehydration/shock and hyperchloremia with aki in the two groups. data will be analysed using spss software. categorical variables will be analysed using chi-square test and if appropriate, multiple logistic regression analysis. continuous variable will be analysed with student's t test and if possible, by linear regression modelling. the differences between the two groups may analysed using analysis of variance (anova). the study will collect anonymous data from 2015 to 2020 from the paediatric intensive care audit network (picanet) database for a tertiary picu servicing the pediatric population of wales.this data is submitted prospectively for audit of clinical outcomes of children admitted for paediatric intensive care in the united kingdom. the study was reviewed by the institutional research and development department and was given exemption for ethics committee review as it does not involve direct patient contact and the data is anonymous. approval was obtained from the relevant database manager, institutional information governance department as well as the health care research wales.

Eligibility criteria:
inclusion criteria * children under 16 years and admitted to pccu or wards in the past 5 years * diagnosis of dka or sepsis/severe bacterial infection/septic shock dka - defined as per the british society for paediatric endocrinology and diabetes (bsped) guidance. sepsis is defined based on the international pediatric sepsis consensus conference guidance (2005) 8.3. exclusion criteria * any patients identified as above but not able to obtain case notes for any reason. * patients with pre-existing kidney conditions * patients with inborn errors of metabolism
does glaucoma cause loss of brain function?

Conditions: Glaucoma

Summary: the purpose of the study is to determine if glaucoma is associated with neurodegenerative changes in areas of the brain other than the occipital lobe. this will help guide the direction of further research in the use of neuroprotective agents in preventing or controlling such changes. the final goal is to improve the quality of life for patients with glaucoma.

death of retinal ganglion cells causes loss of neurons in areas other than just the visual cortex. these neurodegenerative changes decrease the patient's ability to perform the activities of daily living. tensor-based morphometry analysis of magnetic resonance imaging (mri) brain scans will reveal areas of cortical degeneration in glaucoma patients, and the extent of damage in these areas should correlate with patients ability to perform vision-dependent tasks, as measured by the assessment of ability related to vision (aarv). patients with glaucoma who were outliers in two previous studies, assessment of ability related to vision (aarv) or assessment of disability related to vision (adrev), in that they had poor performance-based measure scores despite having midrange visual field scores. mini-mental state exam and t-1 weighted mri brain scan and will be performed.

Eligibility criteria:
inclusion criteria: * patients with glaucoma who were participated in other studies assessment of ability related to vision (aarv) or assessment of disability related to vision (adrev) and were found to be outliers in that they have poor performance-based measure scores (≤ 40) despite having midrange visual field scores (mean deviation of -6 to -20). * age-, gender- and race-matched controls who do not have glaucoma, and who do not have loss of vision for any reason other than cataract or refractive error. exclusion criteria: 1. patients with any type of neurological disease. 2. patients with a cognitive deficit which would affect visual functioning, as revealed by score of less than 25 in the mini mental status examination.

Keywords: glaucoma mri brain scan voxel-based morphometry
a one-year study to evaluate the effects and safety of cp-690,550 in patients with moderate to severe chronic plaque psoriasis

Conditions: Psoriasis

Summary: the main objective of this study is to compare the effects of cp-690,550 with the effects of placebo in patients being treated for moderate to severe chronic plaque psoriasis. this one-year study will also evaluate the safety and tolerability of cp-690,550 versus placebo.


Eligibility criteria:
inclusion criteria: * are 18 years or older with diagnosis for at least 12 months of moderate to severe plaque psoriasis covering as least 10%of body surface area * a psoriasis area and severity index (pasi) score of 12 and are considered to be candidates for systemic or light therapy * no evidence of active or latent tuberculosis exclusion criteria: * non-plaque or drug induced forms of psoriasis * cannot discontinue current oral, injectible or topical therapy for psoriasis or cannot discontinue phototherapy (puva or uvb) * any uncontrolled significant medical condition

Keywords: xeljanz tofacitinib chronic pruritus itch dlqi severe moderate treatment safety efficacy cp-690,550 plaque psoriasis psoriasis vulgaris jax-inhibitor oral treatment