Kornimate/medical-research-clean huggingface dataset:
efficacy and safety evaluation of traditional chinese medicine in the treatment of advanced colorectal cancer

Conditions: Advanced Colorectal Cancer; Traditional Chinese Medicine

Summary: although patients of colorectal cancer use traditional chinese medicine (tcm) herbal therapy extensively in china, no strong evidence exists to demonstrate the safety and survival outcomes of tcm herbal therapy combined with conventional western medicine for treatment of this disease. the purpose of this multi-center perspective cohort study is to evaluate the relationship between tcm herbal therapy and survival outcomes in patients with advanced colorectal cancer.


Eligibility criteria:
inclusion criteria: * histologically confirmed adenocarcinoma of the colon or rectum * tnm classification of stage iv disease according to american joint committee on cancer * between 18 and 80 years old * progression or inability undergone conventional chemotherapy (conventional chemotherapy regimen containing fluorouracil, oxaliplatin, irinotecan based chemotherapy, and all the above regimen should be used before) * expected survival time is over 3 months * signed informed consent exclusion criteria: * serious non-malignant diseases such as heart, renal, and hepatic illnesses * the presence of other types of malignancies * the patients can not take medicine for intestinal obstruction
biological stardadization of d. pteronyssinus and d. farinae allergen extracts

Conditions: Immune System Diseases

Summary: four concentrations of dermatophagoides pteronyssinus and dermatophagoides farinae allergen extracts, together with a positive and negative control, using 10 mg/ml histamine dihydrochloride solution and a glycerinated phenol saline solution, respectively, will be tested in every patient in duplicate on the volar surface of the forearm..

this is an open, unblinded and non-randomized biological assay. the study design is a slight modification of the recommendations proposed by the nordic guidelines.

Eligibility criteria:
inclusion criteria: * clinical history positive inhalation allergy (rhinitis i rhinoconjunctivitis i asthma) against dermatophagoides pteronyssinus or dermatophagoides farinae. * a prick-test positive (average of the papule ≥ 3 mm diameter) with a summary of the same allergen i presence against the allergen specific immunoglobulin e. * the average area of the papule obtained by histamine dihydrochloride to 10 mgml must be greater than or equal 7 mm2. * age: over 18 years of age. * both sexes. exclusion criteria: * subjects outside of the age range. * individuals who have previously received immunotherapy in the last 5 years for the treatment of asthma or the allergic rhinoconjunctivitis induced by allergens that may interfere with the extract mixture of dermatophagoides pteronyssinus or farinae. * subjects with important symptoms of rhinoconjunctivitis i bronchial asthma in which the suspension of the antihistamine treatment for systemic is contraindicated. * subjects that have previously submitted a serious secondary reaction during skin prick test diagnostic tests. * subjects in treatment with ss-blockers. * unstable subjects of clinical point of view (asthma acute, febrile, etc.). * subjects with lesions of active hives, severe active dermographism, severe atopic dermatitis, sunburn, eczema, lesions of psoriasis in the area of realization of the prick test (risk of false positives). * subjects with viral infection activates the herpes simplex or herpes varicella-zoster in the area of realization of the prick test. * subjects that have some pathology in which the administration of adrenaline (hyperthyroidism, hypertension, heart disease, etc.) is contraindicated. * states of the subject that can not offer cooperation and severe psychiatric disorders. * pregnant or women at risk of pregnancy and breastfeeding women.

Keywords: immune system diseases prick test dermatophagoides pteronyssinus dermatophagoides farinae
strategies empowering activities in everyday life: an internet-based occupational therapy intervention

Conditions: Chronic Disease

Summary: the purpose of the study is to evaluate the feasibility, potential outcomes and the implementation process of a second updated version of an internet-based intervention in occupational therapy, focusing on self-management in activities of everyday life to promote health in people with chronic diseases.

the number of people with chronic disease is increasing as is the need of preventive efforts to facilitate their health. chronic diseases are defined as 'long-term health conditions' that require constant attention and/or limit activities of daily living. people living with one or multiple chronic diseases experience difficulties to live an active everyday life and restrictions of engagement in various activities are common. interventions that support their process of change and development of self-management in everyday life in relation to their changed capacity needs to be established. research shows that the access to interventions is facilitated by the use of internet-based solutions. hence, an internet-based occupational therapy intervention 'strategies empowering activities in everyday life' (see) has been developed that will be evaluated in a feasibility trial. the feasibility study is designed as a longitudinal trial with pre-test, post test evaluation without control group embedded in a mixed method approach. data will be collected by assessment tools, qualitative interviews and group interviews. evaluation of the feasibility of the intervention and the study design will be conducted in terms of acceptability, adherence, values, and implementation, from the perspective of patients with chronic disease and health care personnel at different organizational levels in the primary care. the results from this feasibility study will support the continued development of see in future larger-scale evaluation studies. the goal is that see will add to existing interventions and becomes implemented in clinical practice. the results will be published in peer-reviewed scientific journals and presented at conferences.

Eligibility criteria:
inclusion criteria: * diagnosed or at risk of developing a chronic disease/long-term condition such as long-term pain, stress-related conditions, neurological diseases and chronic fatigue syndrome * age: 18-75 years * experiencing difficulties to have an active everyday life and/or experiencing a need to develop self-management strategies in everyday life. * have access to a screen/computer, internet and e-id as well as being able to use them * be able to participate in the program, including be ready for a process of change * understanding of the swedish language in written and oral form. exclusion criteria: * sickness or disease which causes difficulties with understanding written and verbal advice (e.g. mental or cognitive illness). * having an ongoing misuse * receiving palliative care

Keywords: chronic disease self-management activities of daily life internet-based tele-rehabilitation e-health occupational therapy prevention rehabilitation long-term health conditions
a prospective study of electronic symptom reporting via mobile phone among patients with advanced non-small cell lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: symptoms are common among patients with advanced malignancy undergoing treatment, and yet often go unrecognized by treatment providers. in addition to contributing to morbidity, poorly controlled symptoms drive emergency room utilization and hospital admission in this population, representing significant cost to patients, families, and the health care system. systematic collection of patient-reported outcomes (pros) has been proposed as a way to arm providers with the information necessary to intervene early, intensify symptom management, and improve symptom control. recent research suggests that a standardized, web-based program of weekly patient-reported symptom monitoring leads to improved health-related quality of life and reduced acute care utilization; it may also prolong overall survival. despite mounting evidence supporting its use among oncology patients, systematic pro collection is lacking at most cancer centers, and optimal models for collection of pros are poorly understood. the objective of this study is to evaluate prospectively the feasibility of a novel mobile phone-based intervention of weekly symptom reporting, among patients undergoing treatment for advanced non-small cell lung cancer.


Eligibility criteria:
inclusion criteria: * adult patient (age ≥ 18 years) with advanced (metastatic) non-small cell lung cancer, initiating a new line of palliative-intent treatment at abramson cancer center * ability to read and respond to questions in english * ability to provide informed consent to participate in the study * access to a smart phone capable of sms-text messaging and internet access exclusion criteria: * inability to read and respond to questions in english * inability or unwillingness to provide informed consent to participate in the study * inability to engage with sms-text based platform * current enrollment in a clinical trial
evaluation of continuous symptom treatment of adhd

Conditions: Attention Deficit Hyperactivity Disorder

Summary: the purpose of this study is to test the hypothesis that atomoxetine administered orally, once a day, at doses up to 1.4 mg/kg/day for approximately 6 weeks given in the morning is superior to placebo in children with adhd.


Eligibility criteria:
inclusion criteria: * patients must have adhd that meets disease diagnostic criteria as defined by dsm-iv-revised * males or females who are at least 6 years old and no more than 12 years old prior to visit 2 * patients must be able to swallow capsules * patients must be of normal intelligence in the judgment of the investigator. normal intelligence is defined as being without evidence of significant general intellectual deficit and expected to achieve a score of 70 or more if formal iq testing were administered. * laboratory results must show no significant abnormalities (significance is defined as laboratory values requiring acute medical intervention, indicating a serious medical illness, or requiring further medical evaluation in the judgment of the investigator) exclusion criteria: * patients who weigh less than 20 kg or greater than 65 kg at study entry (visit 1) * patients who have a documented history of bipolar i or bipolar ii disorder, or psychosis * patients who have documented autism, asperger's syndrome, or pervasive developmental disorder. * other comorbid psychiatric disorders are not excluded provided that the diagnosis of adhd predates the comorbid disorder, and that the adhd symptoms are the primary source of impairment for the patient * patients taking any antipsychotic medication during the 4 weeks prior to visit 1 are not eligible.
adjunctive bright light therapy for opioid use disorder

Conditions: Opioid Use Disorder; Sleep Disturbance

Summary: investigators propose to conduct a pilot single-blind, parallel arm, randomized placebo-controlled trial evaluating the feasibility, acceptability, and preliminary efficacy of bright light therapy on reward system functioning among patients undergoing medication-assisted treatment for opioid use disorder.

bright light therapy (blt) is a simple, safe, and accessible intervention that can effectively ameliorates sleep disruptions, as well as circadian misalignment and depressive symptoms, and could potentially improve reward system function among patients with oud. beyond seasonal affective disorder, blt has shown efficacy as an intervention for non-seasonal depression, and post-traumatic stress disorder, which all exhibit significant impairment of the dopaminergic reward system and poor sleep quality as key symptoms. investigators propose to conduct a pilot single-blind, parallel arm, randomized placebo-controlled trial evaluating the feasibility, acceptability, and preliminary efficacy of blt on reward system functioning among patients undergoing medication-assisted treatment for oud. the present study will establish feasibility for a larger randomized-clinical trial proposal.

Eligibility criteria:
inclusion criteria: * age between 18 and 65 * ability to speak, write, and read in english * past 2 weeks of insomnia as evidenced by insomnia severity index (isi) total score of ≥10 * enrolled in outpatient medication-assisted treatment for oud (i.e., either methadone or buprenorphine treatment) * been in medication-assisted treatment for at least 3 months * at least one month of stable methadone or buprenorphine dose * have a smartphone exclusion criteria: * lifetime history of bipolar disorder or mania * current narcolepsy, sleep paralysis, or restless leg syndrome as assessed by medical history * history of seizure disorders/epilepsy * the stop-bang score for obstructive sleep apnea ≥ 5 * retinal pathology, history of eye surgery or taking photosensitizing medications (e.g., lithium, l-tryptophan) * current regular use of melatonin * have circumstances that would interfere with study participation (e.g., impending jail sentence) * previous experience with bright light therapy * working a night shift or traveling outside the arizona time zone in the past month * pregnant, trying to get pregnant, or breastfeeding * currently wearing prescription glasses with blue-light protection

Keywords: opioid use disorder bright light therapy reward function methadone
case management for frequent users of the emergency department

Conditions: Frequent Users of the Emergency Department; Vulnerable Populations

Summary: the purpose of this study is to evaluate a specific case management intervention for frequent users (fu) of emergency department (ed). compared to infrequent or non-users, most of the ed-fu visitors are identified as vulnerable patients because they are more likely to be of low social and economical status, be more isolated and live alone. they report more chronic medical conditions, have a higher mortality rate and consume more healthcare resources. in the literature, interventions aimed at improving the management of ed-fu have demonstrated several positive outcomes, but there are still some knowledge gaps. the proposed project tests the hypotheses that case management intervention as compared with standard emergency care * is a more efficient use of healthcare resources and reduces ed attendance, * is cost-saving and * improves quality of life, * altogether leading to favorable cost-utility ratio.


Eligibility criteria:
inclusion criteria: * 5 or more attendances during the previous 12 months at the emergency department of the university hospital of lausanne * be capable of communicating in any of the languages spoken by the team (i.e. french, english, german, italian and spanish) or through a community interpreter exclusion criteria: * patients who cannot give informed consent or are ineligible to receive case managers services (e.g. acutely confused, acutely psychotic, intoxicated) * patients who are in prison * patients with a diagnose of cognitive disorders (delirium, dementia, and other cognitive disorders) * patients who are not expected to survive at least 18 months after enrollment * patients who will not remain in switzerland for 12 to 18 months after enrollment * family members of a participant already included

Keywords: frequent users of the emergency department vulnerable populations case management cost savings intervention quality of life number of emergency department visits
study to evaluate the clinical outcomes in adults with covid-19 who have been treated with remdesivir.

Conditions: Covid19

Summary: this is a multi-centre, multi-country retrospective cohort study. at least 450covid-19 cases from up to 20 participating study sites who meet all eligibility criteria will be included in the analysis. deidentified data will be extracted from electronic medical record (emr) databases, clinical registries, case series or additional sources from participating sites and countries, and then entered into a structured e-crf system. addition, each site/country will be surveyed to determine the local standard of care therapy for covid-19 infection and to determine if standard protocols were/are in place for the use of remdesivir and if/how the protocols changed over time.


Eligibility criteria:
inclusion criteria: all adult participants with covid-19 confirmed by pcr who meet the following criteria: * hospitalised after august 31st,2020 * receivedat least one dose of remdesivir(rdv)at anytime during hospitalisation exclusion criteria: * received remdesivir as part of a clinical trial, compassionate use or expanded access program * received remdesivir prior to this admission at any other health facility than the research sites and whose health records are available.
maximizing energy and reducing fatigue in breast cancer survivors

Conditions: Breast Cancer Survivor; Cancer Related Fatigue

Summary: this study is testing a program called maximizing energy to see if it can help women who have finished breast cancer treatment manage their fatigue. the study has two main goals: 1. check if the program can be successfully delivered - researchers will see if women are willing to join and stay in the study, if they follow the program, and if they find it helpful. 2. see if the program works - researchers will compare maximizing energy to a general health education program to see which one helps reduce cancer-related fatigue better. participant will: 1. take tests to see if they qualify and to measure their fatigue. 2. be randomized to receive maximizing energy or health education interventions for 6 sessions over the internet 3. after the sessions and again one month later, repeat some tests to see if their fatigue has improved.


Eligibility criteria:
inclusion criteria: * adult (18 years and older) pre and post-menopausal female at birth diagnosed with stages i-iiia breast cancer, * completed primary treatment for breast cancer (surgery, chemotherapy, radiation) at least 6 months prior to ensure that fatigue is stable and chronic, - moderate to severe fatigue based on score ≥ 4 on the 7-point fatigue severity scale, * able to speak and understand english * has a mobile device that runs on the apple or android platform exclusion criteria: * major depressive disorder, mania, hypomania, psychosis, or substance abuse in the past 3 months and * disability due to diagnoses other than breast cancer.

Keywords: self-management problem solving therapy actigraphy occupational therapy
open-label safety study of axs-05 in subjects with depression

Conditions: Major Depressive Disorder; Treatment Resistant Depression; Depression

Summary: an open-label, long-term, safety study of axs-05 in patients with major depressive disorder (mdd), including treatment resistant depression.

a multi-center, open-label, long-term study to evaluate the safety and efficacy of axs-05 in patients with major depressive disorder, including treatment resistant depression, treated for up to one year.

Eligibility criteria:
inclusion criteria: * diagnosis of major depressive disorder, including treatment resistant depression * body mass index (bmi) between 18 and 40 kg/m\^2, inclusive * agree to use adequate method of contraception for the duration of the study * additional criteria may apply exclusion criteria: * suicide risk * pregnant, breastfeeding, or planning to become pregnant or breastfeed during the study * additional criteria may apply

Keywords: depression axs-05 dextromethorphan bupropion dopamine reuptake inhibitor nmda receptor antagonist nicotinic acetylcholine receptor antagonist serotonin reuptake inhibitor axsome therapeutics norepinephrine reuptake inhibitor sigma-1 receptor agonist glutamate modulator antidepressant
orthostatic intolerance and hypotension after administration of morphine in patients prior to hip or knee arthroplasty

Conditions: Orthostatic Hypotension; Orthostatic Intolerance

Summary: incidence of orthostatic intolerance and orthostatic hypotension after intravenous administration of morphine in patients prior to hip or knee arthroplasty.

early postoperative mobilization is crucial for recovery of patients undergoing surgery in the multimodal fast-track approach to perioperative care, since physical immobilization is highly associated with increased risk of postoperative complications and prolonged hospital length of stay. postoperative mobilization is often delayed due to patients experiencing orthostatic hypotension (oh), defined as a drop in systolic blood pressure \> 20 mmhg or diastolic blood pressure \> 10 mmhg, or orthostatic intolerance (oi), characterized by dizziness, blurred vision, nausea, vomiting, sensation of heat or syncope. previous studies have found a high incidence of postoperative oi (\> 40 %) among patients undergoing total hip arthroplasty. a possible causative factor to the high occurrence of oh and oi after surgery could be postoperative pain management by administration of morphine. morphine is known to have many side-effects including nausea, vomiting, dizziness and orthostatic hypotension. the object of this study is to isolate and estimate the effect of intravenous morphine on the incidence of oh and oi.

Eligibility criteria:
inclusion criteria: * patients undergoing primary unilateral total hip arthroplasty (tha), total knee arthroplasty (tka) or unicompartmental knee arthroplasty (uka) * patients \> 18 * patients that understand and speak danish * patients that have provided written informed consent exclusion criteria: * alcohol or substance abuse * habitual use of opioids * habitual use of anxiolytic, antidepressant and/or antipsychotic drugs * history of previous orthostatic intolerance or hypotension * cognitive dysfunction * glomerular filtration rate (gfr) \< 30 ml/min * cardiac arrhythmia

Keywords: orthostatic hypotension orthostatic intolerance morphine autonomic dysfunction
testing of cognitive behavioral therapy resource of turkish version

Conditions: Dental Anxiety

Summary: this study aimed to evaluate the cognitive behavioral therapy source of turkish version of the 'message to dentist' (mtd) with children attending two dental settings.

children aged 5-16 years attending a dental faculty clinic and a private dental office were invited to complete the mtd form. children were asked to report how worried they felt, their level of pain they anticipated and the actual level of pain they experienced on a scale of 1-10 (with 1 being the best outcome).

Eligibility criteria:
inclusion criteria: having dental anxiety but not having negative experiences during dental treatment in childhood or adolescence * without any systemical and mental diasabilities * who volunteered to participate in the study and whose parental consent was obtained. exclusion criteria: * not have dental anxiety * having any systemical or mental disability * having negative experiences during dental treatment in childhood or adolescence * and who did not volunteer to participate in the study and did not have parental consent for the study were excluded.

Keywords: dental anxiety cognitive behavioral therapy pediatric dentistry