Kornimate/medical-research-clean huggingface dataset:
the thrombus aspiration during pci after thrombolysis in stemi

Conditions: ST-segment Elevation Myocardial Infarction

Summary: the goal of this clinical trial is to determine whether thrombus aspiration combined with percutaneous coronary intervention (pci) improves clinical outcomes in st-segment elevation myocardial infarction (stemi) patients with high thrombus burden post-thrombolysis, compared to pci alone. the study population includes 3500 stemi patients, confirmed by diagnosis, who are transferred to pci centers after receiving thrombolysis and have no contraindications to thrombolysis.the main questions it aims to answer are: 1. does thrombus aspiration reduce 30-day major adverse cardiovascular events (mace), including cardiovascular death, recurrent myocardial infarction, stroke, or heart failure rehospitalization? 2. can thrombus aspiration improve microcirculation and clinical outcomes for high thrombus burden patients after thrombolysis? researchers will compare patients randomly assigned to receive thrombus aspiration combined with pci versus those who receive pci alone to evaluate the effects on reducing mace and improving clinical recovery. participants will: undergo initial thrombolysis followed by transfer to pci centers. be randomly assigned in a 1:1 ratio to receive either thrombus aspiration combined with pci or pci alone. be followed for 30 days post-treatment to assess mace and other clinical outcomes.


Eligibility criteria:
inclusion criteria: 1. diagnosed with stemi. 2. no contraindications for thrombolysis and has received thrombolytic treatment. 3. undergoing coronary angiography within 2 to 24 hours post-thrombolysis. 4. angiographic results confirm timi thrombus load ≥ 4 and residual stenosis \> 50%. exclusion criteria: 1. contraindications for thrombolysis. 2. cardiogenic shock. 3. need for coronary artery bypass grafting. 4. age less than 18 years. 5. life expectancy of less than 6 months. 6. unable to provide informed consent.

Keywords: st-segment elevation myocardial infarction thrombus aspiration percutaneous coronary intervention high thrombus burden randomized controlled trial
changes between lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis

Conditions: Myopia; Astigmatism

Summary: the aim is to evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after lenticule extraction (flex) and femtosecond laser-assisted laser in situ keratomileusis (fs-lasik) procedures.

over the past few years, laser in situ keratomileusis with a femtosecond laser-created flap (fs-lasik)has been a popular ophthalmic procedure for the correction of refractive error. this first all-in-one fs-laser system was designed to perform the refractive lenticule extraction (relex) procedures, femtosecond lenticule extraction (flex).they have the same feature: corneal flap. ocular surface disruption during corneal refractive surgery is commonly considered to be closely related to the development of dry eye. multiple etiologies contribute to this ocular surface disruption, including the flap creation and stromal ablation involved in previous refractive surgery techniques. corneal nerve damage has been considered the main cause of dry eye, due to disrupted afferent sensory nerves, reduced blink reflex, and increased tear evaporation leading to tear film instability. in addition, postoperative inflammatory mediator fluctuations are also a key factor related to ocular surface damage. extensive research has described the effects of cytokines, chemokines and growth factors in modulating corneal wound healing, cell migration, and apoptosis on the ocular surface after refractive surgery. this prospective clinical study is going to assess the short-term changes in ocular surface measures and tear inflammatory mediators after lenticule extraction (flex) and femtosecond laser-assisted laser in situ keratomileusis (fs-lasik) procedures.

Eligibility criteria:
inclusion criteria: * minimum age of 18 years(range from 18 year to 25 years) * corneal thickness 500 μm with calculated residual stromal bed after treatment greater than 300 μm * preoperative spherical equivalent refraction between- 2.00 diopter (d) and -6.50 d.preoperative cylindrical equivalent refraction between -0.25 d and -1.50 d. * preoperative corneal curvature from 41.0 d to 46.0 d with a regular topographic pattern monocular best corrected visual acuity of 20/20 or better and stable refractive error (less than 0.5 d change) for 24 months before surgery。 exclusion criteria: * systemic disease that contraindicated the surgery (such as diabetes, glaucoma and systemic collagen vascular disease) * corneal abnormality or disease. * a history of tear supplement usage or contact lens wear during the past year.

Keywords: lenticule extraction femtosecond laser-assisted laser in situ keratomileusis tear inflammatory mediators
pressure ulcers in knee replacement surgery

Conditions: Knee Osteoarthritis; Pressure Ulcer

Summary: from the point of view of nursing to know exactly the different risk factors for the onset of pressure ulcers is very important as it allows to accurately orient preventive care interventions. all the variable that could influence the development of pressure ulcer in patients undergoing knee replacement surgery are identified and collected: age, sex, body max index, risk to develop pressure ulcer (braden score), treatment to prevent pressure ulcers (typology of the devices used, such as air mattresses with alternating or static pressure, heel drains, frequency of mobilization carried out by both the patient care), management of eventual incontinence (use of diapers, urinary catheter), type of anesthesia, type of analgesia, length of stay, the asa physical status classification system (asa score), comorbidity, cancer, use of devices for controlling the position of the operated limb (foam valve), the number of physical therapy sessions actually carried out.


Eligibility criteria:
inclusion criteria: * primary knee joint replacement * secondary knee joint replacement exclusion criteria: * cancer patients * adult or senior with pressure ulcer at the heel
safety and tolerability of pasireotide lar in combination with everolimus in advanced metastatic nets

Conditions: Gastroenteropancreatic Neuroendocrine Tumor of the Pulmonary ot Gastroenteropancreatic System

Summary: the purpose of this study is to assess the safety and tolerability of pasireotide lar in combination with everolimus in advanced metastatic gastroenteropancreatic or pulmonary neuroendocrine tumors (net).


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of grade 1/2 advanced pulmonary or gastroenteropancreatic neuroendocrine tumor * progressive disease within last 12 months (only patients with nonfunctional tumors) * documented liver metastasis * measurable disease per recist determined by multiphase mri or triphasic ct exclusion criteria: * previous treatment with radiolabeled somatostatin analogs within 12 months prior to reporting baseline symptoms * previous treatment with mtor inhibitors or pasireotide * patients who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study * women who are pregnant or lactating other protocol-defined inclusion/exclusion criteria may apply

Keywords: carcinoid tumor, gastroenteropancreatic neuroendocrine tumors, pulmonary neuroendocrine tumors, pasireotide lar, som230 lar, everolimus, rad001, advanced neuroendocrine tumor, gastroenteropancreatic system
home sleep apnea machine in evaluating obstructive sleep apnea in patients with stage iii-iv head and neck cancer

Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma; Metastatic Head and Neck Squamous Cell Carcinoma

Summary: this trial studies information from a home sleep apnea machine to evaluate obstructive sleep apnea in patients with stage iii-iv head and neck cancer. sleep apnea (trouble breathing during sleep) can occur in head and neck cancer patients who have swelling in their neck. wearing a sleep apnea machine overnight may help doctors evaluate obstructive sleep apnea in patients with head and neck cancer.

this is a single center study in hnscc subjects to assess the effects of crt on osa.. patients will be screened with a physical exam and questionnaire (the berlin questionnaire, stop-bang, psqi) and when eligible, will have the home sleep study (specific aim 1). the low risk group (based on the physical exam and questionnaire) with stage ivc will not be eligible for the home sleep study and will concentrate on palliation of their symptoms. for locally advanced hnscc patients undergoing definitive crt, post crt home sleep study results will also be assessed (specific aim 2). when the patient is diagnosed with osa based on the home sleep study, or if the home sleep study is negative but if the patient had high risks based on the screening process, the patient will be referred to the sleep medicine clinic. if life-threatening obstructive sleep apnea is found, the patient will be referred to sleep medicine clinic right away and will be taken off study. otherwise, the patients will prioritize their definitive crt for hnscc, and will be referred to sleep medicine clinic once crt has been completed.

Eligibility criteria:
inclusion criteria: * locally advanced (stage iii-ivb) and metastatic (stage ivc) hnscc who are referred to medical oncology. patients may not have received upfront definitive surgical resection of the primary tumor or upfront neck dissection. * patients must be able to operate the home sleep study device. * eastern cooperative oncology group (ecog) performance status 0-2. exclusion criteria: * patients should not have received any prior systemic chemotherapy or radiation therapy for locally advanced or metastatic hnscc. * patients with tracheostomy or those requiring the assistance of a ventilator will be ineligible for the study.
posturographic characteristics of eccentric, isometric and concentric movements

Conditions: Chronic Pain; Musculoskeletal Pain

Summary: determine the posturographic characteristics of eccentric, isometric and concentric movements in healthy subjects as well as in subjects with chronic, orthopedic conditions / pain not involving the lower extremities. the squatting movement (going down from a stand up position, bending the ankle, knee and hip joints, and then returning to the stand up position, while not lifting the feet from the supporting ground surface) is a simple motion that involves all three types of movements: eccentric (the going down), isometric (holding the down position for a couple of seconds) and concentric (the coming up). it is hypothesized that non-healthy subjects will not have "smooth" movements, and posturography could be used to separate between healthy and non-healthy subjects.

subjects will undergo computerized dynamic posturography (cdp) testing using the modified clinical testing of sensory integration in balance (mctsib) protocol: the subjects will be required to stand on a hard or compliant surface (a 4" tall foam cushion of known mechanical properties) in a comfortable posture, feet shoulder width, with eyes open or closed, head straight and arms to the side and free to move, gazing forward, and breathing normally. subsequently, subjects will be asked to stand first on the right leg and then on the left leg, raising the other leg (flexing the hip about 45 degrees), bending (flexing) the knee 90 degrees, keeping the arms extended and moving them laterally (abduct shoulders to 45 degrees and extend both elbows) to help maintaining balance with eyes open. finally, subjects will be asked to perform 10 repetition of the squatting movement, with the operator pacing them (telling them when to start and when to stop the movements). the results of the mctsib, combined with an initial physical and neurological examination will be used to classify the subjects into the healthy and non healthy group.

Eligibility criteria:
inclusion criteria: * subjects with chronic, orthopedic conditions / pain exclusion criteria: * involving the lower extremities

Keywords: balance, postural postural equilibrium
the impact of vitamin c on postoperative acute kidney injury in risk patients undergoing valvular heart surgery

Conditions: Acute Kidney Injury

Summary: in cases of cardiac surgery or sepsis which cause inflammation, oxidative stress, endothelial injury and vasoplegia, serum vitamin c concentration is sharply decreased. the anti-inflammatory and anti-oxidant effects of vitamin c and the effects of reducing vasoconstrictor use have been demonstrated in patients with sepsis and septic shock, however, the foregoing effects have not been validated in patients undergoing cardiac surgery. in this study, investigators investigate the effect of intravenous vitamin c on the incidence of acute renal injury after valvular heart surgery.


Eligibility criteria:
inclusion criteria: * patients older than 20 years and undergoing elective valvular heart surgery whose preoperative acute renal failure score is ≥3 (moderate to severe risk). exclusion criteria: * emergency operation * cardiogenic shock or ventricular-assist device (eg. ecmo, iabp) * severe chronic kidney disease (gfr(ckd-epi) \<30ml/min/1.73m2) * patients with past history of gout or renal stone or hyperoxaluria or cystinuria * hemolytic anemia due to pyruvate kinase deficiency or glucose-6-phosphate dehydrogenase deficiency * sicklemia or thalassemia * hemochromatosis * allergy to disodium ethylenediamine-tetraacetate or ascorbic acid * patients taking aspirin up to 3 days before surgery * patients taking antiepileptic drug or fluphenazine or steroid * patients taking vitamin c within a month of surgery * pregnant or lactating women * patients who cannot understand the informed consent (eg. foreigner)

Keywords: postoperative acute kidney injury
explore biomarkers associated with prognosis of recurrent and metastatic crc after surgery by multi-omics methods

Conditions: Colorectal Cancer Metastatic

Summary: this project is the first application, which is applied as a single center project and applied according to the screening quantity. this project is a multi-omics approach to explore biomarkers associated with prognosis after secondary radical resection of recurrent and metastatic colorectal cancer. main research objectives: 1. to detect dna mutation and methylation in tumor tissues by ngs detection technology (the methylation dimension should be detected in adjacent tissues at the same time), and to explore specific molecular markers related to prognosis; 2. using ngs test technology of blood in patients with preoperative and postoperative blood ctdna mutations and methylation double dimension testing, respectively, to explore the preoperative and postoperative ctdna mutations and the correlation between methylation status and recurrence, including but not limited to predict patients with recurrence of sensitivity, specificity, positive predictive value, negative predictive value and recurrence warning time and other indicators. main contents: this study intends to include single site for the first time/organ metastasis after radical treatment and surgical indications again in patients with colorectal adenocarcinoma (including but not limited to spread to the liver, lung metastasis, peritoneal metastasis, lymph node metastasis and other organ metastasis), collected in patients with preoperative peripheral blood and tissue samples, tissue adjacent to carcinoma and postoperative peripheral blood, ngs detection technology was used to detect dna and mutation in the relevant samples, combined with clinical treatment and prognosis information of patients, and then explore biomarkers for predicting recurrence risk.


Eligibility criteria:
inclusion criteria: 1. colorectal cancer patients with first recurrence and metastasis after previous radical resection 2. single site/organ metastasis is indicative of reoperation 3. adenocarcinoma diagnosed by histology or cytology 4. at the time of signing the informed consent, the applicant must be 18 years old or older 5. life expectancy is at least 12 weeks 6. ecog score 0\~1 exclusion criteria: 1. currently participating in the intervention study treatment, or receiving other drugs or study devices within 4 weeks before enrollment 2. concurrent with other malignant tumors 3. the investigator determined that the patient had other serious diseases that might affect follow-up and short-term survival 4. cardiac function nyha class iii or iv heart disease 5. the presence of definite peripheral nerve disease 6. there is definite hearing loss 7. other researchers think it is not suitable for inclusion

Keywords: colorectal cancer colorectal cancer metastatic multi-omics method biomarker
hypersensitivity to opening of atp-sensitive potassium channels in post-traumatic headache

Conditions: Post-Traumatic Headache

Summary: the aim is to investigate whether opening of atp-sensitive potassium (katp) channels induces headache with migraine-like features in people with persistent post-traumatic headache (pth) attributed to mild traumatic brain injury (mtbi).


Eligibility criteria:
inclusion criteria: * age 18 to 65 years of age upon entry into screening * history of persistent headache attributed to mild traumatic injury to the head for ≥ 12 months and in accordance with the international classification of headache disorders, 3rd edition (ichd-3) * ≥ 4 monthly headache days on average across the 3 months prior to screening * provision of informed consent prior to initiation of any study-specific activities/procedures. exclusion criteria: * \> 1 mild traumatic injury to the head * history of any primary or secondary headache disorder prior to mild traumatic injury to the head (except for infrequent episodic tension-type headache) * history of moderate or severe injury to the head * history of whiplash injury * history of craniotomy * history or evidence of any other clinically significant disorder, condition or disease (except for those outlined above) than, in the opinion of the site investigator, would pose a risk to subject safety or interfere with study evaluation, procedures or completion * the subject is at risk of self-harm or harm to others as evidenced by past suicidal behavior * female subjects of childbearing potential with a positive pregnancy test during any study visit * cardiovascular disease of any kind, including cerebrovascular diseases * hypertension (systolic blood pressure of ≥150 mmhg and/or diastolic blood pressure of ≥100 mmhg) prior to the start of infusion on the experimental day * hypotension (systolic blood pressure of ≤90 mmhg and/or diastolic blood pressure of ≤50 mmhg) * initiation, discontinuation, or change of dosing of prophylactic medications within 2 months prior to study inclusion * intake of acute medications (e.g. analgesics, triptans) within 48 hours of infusion start * baseline headache intensity of \>3 on an 11-point numeric rating scale (0 being no headache, 10 being the worst imaginable headache) * baseline headache with migraine-like features or self-reported baseline headache that mimics the subjects' usual headache with migraine-like features

Keywords: headache pain
the cost-effectiveness of stapes surgery for otosclerosis performed under local versus general anesthesia

Conditions: Otosclerosis

Summary: otosclerosis is a localized disorder of the otic capsule, characterized by bone resorption anterior to the oval window in the region of the fissula ante fenestram. this process leads to new sclerotic bone formation, resulting in stapes footplate fixation. it is one of the most common causes of progressive conductive hearing loss in young adults between the age of 30 and 50 year-old. as the disease advances, hearing loss can become mixed and even purely sensorineural due to the pathological process extending into the cochlea. stapes surgery is the gold standard procedure for restoring mechanical sound transmission through the middle ear. for patients who are not candidates for surgery, hearing aids offer a valid alternative. over the years, stapes surgery has evolved into a minimally invasive procedure that can be safely performed as day surgery, under either local or general anesthesia. the covid-19 crisis has exacerbated a shortage in anesthesiology teams, limiting operating room availability. to address this issue, stapes surgery for otosclerosis under local anesthesia were increasingly performed. local anesthesia has several advantages: it allows for immediate hearing tests after prosthesis placement, enabling early detection and correction of vertigo caused by prosthesis displacement, thus minimizing major complications. additionally, local anesthesia reduces exposure to general anesthesia, thereby decreasing postoperative morbidities. while there are few studies comparing outcomes and complications of stapes surgery based on the type of anesthesia, a systematic review in 2013 found no difference in postoperative air-bone gap (abg), sensorineural hearing loss (snhl), or postoperative vertigo between procedures performed under local versus general anesthesia. no studies have evaluated or compared the cost-effectiveness of stapes surgery for otosclerosis performed under local versus general anesthesia. this study hypotheses that patients undergoing stapes surgery under local anesthesia will have equivalent outcomes to those under general anesthesia, with the potential for reduced costs and operative time.


Eligibility criteria:
inclusion criteria: * patients diagnosed with otosclerosis and indicated for stapes surgery. * patients who underwent primary stapes surgery between january 1, 2022, and december 31, 2023. * surgery performed by utilizing the co2 laser technique (stapedotomy). * patients with complete medical records and audiometry data. * subjects do not object to the use of their personal data. exclusion criteria: * patients with incomplete medical records (pre- or postoperative audiologic data were unavailable). * patients with other concurrent middle ear pathologies. * patients who underwent revision surgery for otosclerosis. * performed by utilizing the microdrill technique or stapedectomy.