Kornimate/medical-research-clean huggingface dataset:
a study to observe the treatment patterns and outcomes of patients in japan with kidney cancer that is unable to be removed by surgery or that has spread

Conditions: Renal Cell Carcinoma

Summary: a medical review chart study in japan to describe the treatment patterns and outcomes of patients with kidney cancer that is unable to be removed by surgery or that has spread. the clinical data is to be abstracted using electronic data capture (edc) from patient medical records in japan.


Eligibility criteria:
for more information regarding bristol-myers squibb clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * adults 20 years and older at the time of initial diagnosis of mrcc * alive or deceased as of the date of data collection * diagnosis of mrcc between 01-jan-2012 and 31-aug-2015 exclusion criteria: * previously and/or currently enrolled in rcc clinical trials * patients have primary cancer other than renal cell cancer
lifestyle behavioural intervention on breast cancer survivors for the treatment of overweight/obesity.

Conditions: Breast Cancer Female; Overweight and Obesity

Summary: the goal of this clinical trial is to compare a behavioural lifestyle intervention program (bl) to usual care (uc) in breast cancer survivors. the main questions it aims to answer are: 1. if the participants of the bl group will lose more weight than the uc group. 2. if the participants of the bl group will have more lifestyle benefits than the uc group. volunteers will participate in a 24-week behavioural program. this program aims to improve their nutrition and physical activity in order to lose at least 10% of their initial body weight.

eligible participants should be female breast cancer survivors between the ages of 18 and 65, with a bmi between 25 and 40 kg/m2, and no active cancer therapy or ongoing treatment, except for hormonal or immune therapy. the usual care (uc) group will receive wcrf cancer prevention recommendations. the behavioural lifestyle intervention program (bl) group will participate in a 24-week intervention targeting diet and physical activity to lose weight. the program will be considered successful if participants lose at least 10% of their initial body weight. a secondary goal is to improve their nutrition and physical activity levels. the third and last goal is to improve their overall quality of life and their anxiety levels. the behavioral program includes in-person online meetings, group online sessions, and digital counseling material. considering that participants will be residing all around greece, an internet videoconferencing technology will be required. a qualitative study incorporating focus groups undertaken prior to this study to establish the methodology resulted in the utilization of synchronous and asynchronous media, as well as a combination of in-person and group sessions.

Eligibility criteria:
inclusion criteria: * bmi between 25 and 40 kg/m2 exclusion criteria: * active cancer or any ongoing treatment except hormonal or immune therapy

Keywords: behavioural intervention lifestyle intervention nutrition and physical activity breast cancer survivors overweight and obesity digital counselling
alzheimer's disease treatment with combination of 40hz light and cognitive therapy

Conditions: Alzheimer Disease; Mild Cognitive Impairment; Dementia; Cognition Disorders in Old Age; Cognitive Decline; Cognitive Deterioration

Summary: electrical activity in the brain known as "gamma" brainwaves help connect and process information throughout the brain. these gamma waves are diminished in alzheimer's disease. new research in alzheimer's disease mouse models shows that exposure to light flickering at the rate of 40 flashes per second or 40hz increased gamma brainwaves and led to clearing of beta amyloid plaques in the brain, a key abnormality in alzheimer's disease. this project will test the ability of a novel ipad app (alzlife https://www.alz.life/) that delivers light therapy at 40 hz combined with cognitive therapy to improve cognition, function, and quality of life in alzheimer's disease.

new research suggests that exposure to a light flickering at 40hz may promote gamma brain wave activity through the photic entrainment phenomenon. these waves have the potential to activate critical cleaning cells in the brain that could eliminate beta amyloid plaques. the most recent research on light therapy for alzheimer's disease appeared in the journal nature in 2017, entitled "how flashing lights and pink noise might banish alzheimer's, improve memory and more" (the full article can be freely accessed at: https://www.nature.com/articles/d41586-018-02391-6) and in 2016, entitled "gamma frequency entrainment attenuates amyloid load and modifies microglia" (the article abstract can be accessed at: https://www.nature.com/articles/nature20587). researchers from mit found that shining a strobe light into the eyes of mice with a rodent version of alzheimer's disease encouraged protective cells to phagocytize the harmful proteins that accumulate in the brain. the perfect rate of flashes was determined to be 40 per second. exposure to the flashing light for an hour (light therapy) led to a noticeable reduction in beta amyloid levels the next day in regions of the neocortex and hippocampus. when done every day for a week, beta amyloid levels were greatly reduced. in addition, there is a significant body of evidence that computerized brain training (cognitive therapy) improves the memory of patients with alzheimer's and dementia, which could help avert some symptoms of cognitive decline. the synergistic combination of light and cognitive therapy utilized in alzlife has the potential to improve the brain's function better than either of these therapies alone. this project will test the ability of a novel ipad app ("alzlife") that delivers light therapy at 40 hz combined with cognitive therapy to improve cognition, function, and quality of life in alzheimer's disease.

Eligibility criteria:
inclusion criteria: * alzheimer's disease * cognitive impairment exclusion criteria: * any previously noted epileptic seizures, including febrile seizures. * any significant disease of the eye, such as macular degeneration. since the 40hz light therapy is delivered via eye stimulation, healthy eyes are required.

Keywords: alzheimer disease alzheimer's dementia
bridge-enhanced acl repair vs acl reconstruction

Conditions: Anterior Cruciate Ligament Tear

Summary: the goal of this trial is to compare the efficacy of the bridge-enhanced anterior cruciate ligament repair (bear™) technique with the current method of treatment for anterior cruciate ligament (acl) injuries, acl reconstruction.

enrolled patients will be randomized to either the bridge-enhanced acl repair (bear) technique (new treatment) or an acl reconstruction (current gold standard of treatment).

Eligibility criteria:
inclusion criteria: * age: 14 to 35 years of age. * sex: both male and female * acl: complete tear * time from injury to surgery: ≤45 days * mri: acl tissue present on pre-operative mri - at least 50% of the acl length must still be attached to the tibial plateau exclusion criteria: * prior surgery on affected knee * prior joint infection on affected knee * regular use of tobacco or nicotine * use of corticosteroid within last 3 months * history of chemotherapy treatment * history of sickle cell disease * history of anaphylaxis * any condition that could affect healing or infection risk (diabetes, inflammatory arthritis, etc) * operative posterolateral corner injury (lcl complete tear, biceps femoris tendon avulsion, tear of the arcuate ligament, tear of the popliteus ligament) * grade iii medial collateral ligament injury * complete patellar dislocation * known allergy to bovine, beef or cow products
running title: walking to music and in silence on a treadmill

Conditions: Multiple Sclerosis

Summary: this work is embedded in the context of auditory-motor coupling, which entails the engagement of two systems; the interaction between the music (or repetitive auditory stimuli) and a walking individual (repetitive movements of footfall). in previous studies, the investigators have shown that synchronising steps to beats in music have shown to be feasible in persons with multiple sclerosis, showing increase of step frequency and reduced perceived fatigue\[1, 2\]. in this current work, the investigators expand previous findings with a pilot intervention study, to investigate if synchronisation is necessary to improve cognitive and motor functions. the proposed experiment includes 30 participants, randomised to three arms of a pilot intervention (10 participants per arm). with the intention of a further case-study analysis, the inestigators request to include 4 additional participants (2 pwms with cognitive impairment, and 2 persons with cerebellar lesion) to only follow the intervention arm 1.


Eligibility criteria:
inclusion criteria: * a diagnosis of ms if \>1, * no relapses \>1 month, * ability to walk for 12minutes, * ability to walk independently on a treadmill * walking speed between 0.8-1.2m/s. exclusion criteria: * amusia, * deafness, * cognitive impairment hindering understanding of study instructions, * pregnancy.
nac- nafld and cushing

Conditions: Cushing Syndrome; Fatty Liver Disease

Summary: cushing's syndrome is a rare disease resulting from prolonged exposure to high levels of circulating cortisol. clinical manifestations are variable but many patients present a metabolic syndrome (abdominal obesity, insulin resistance, dyslipidemia, hypertension). with regard to the liver, experimental data have shown that excess cortisol leads in an increase in lipogenesis and a reduction in the oxidation of fatty acids. this, in association with an accumulation of visceral adipose tissue and deregulation of adipokines, may contribute to the development of hepatic steatosis in animals. however, few data is available in humans with only one study of 50 patients with cushing's syndrome estimating the prevalence of hepatic steatosis at 20%. nafld (non-alcoholic fatty liver disease), is defined as the presence of hepatic steatosis in the absence of secondary causes of intrahepatic fat accumulation. it is a heterogeneous disease ranging from simple liver steatosis, whose prognosis is generally considered to be benign, to inflammation (nash, non-alcoholic steato-hepatitis) which may progress to fibrosis, cirrhosis and an increased risk of hepatocellular carcinoma. the prognosis for nafld is mainly related to the severity of hepatic fibrosis. in cushing's syndrome, normalization of cortisol production is the most effective strategy to improve co-morbidities associated with hypercortisolism. however, some of these complications, especially the metabolic co morbidities, could not be completely reversible and no data is available about resolution of hepatic steatosis.


Eligibility criteria:
inclusion criteria: * age \> 18 years * active cushing's syndrome exclusion criteria: * other common causes of chronic liver disease (hbv, hcv, haemochromatosis, alcohol) * contraindication to mri
a study of methods to reduce anxiety in preoperative elective surgical patients

Conditions: Anxiety

Summary: patients are often anxious immediately before surgery. the investigators hypothesis is that a warming blanket is as effective as the sedative midazolam in allaying anxiety before surgery.

the investigators are randomising patients aged 18-70 having elective surgery to 1) a cotton blanket and reassurance as required; 2) midazolam, a cotton blanket and reassurance as required; and 3) forced-air warming, a cotton blanket and reassurance as required. the primary endpoint is a visual analog scale of anxiety.

Eligibility criteria:
inclusion criteria: * patients aged between 18 and 70 years * male and female * presenting for elective surgery * requiring general anaesthesia * asa 1-3 exclusion criteria: * cardiothoracic and intracranial surgery * day case surgery * pre-existing anxiety disorder * patients on psychotropic drugs preoperatively febrile patients t \> 37.5 degrees celsius allergy to midazolam obstructive sleep apnoea diagnosed on sleep study

Keywords: anxiety midazolam forced-air warming
effect of tertiary a-level hospital remote intervention on macce, adherence to drugs and risk factors control in patients with stable coronary artery disease compared with traditional community hospital follow-up

Conditions: Stable Chronic Angina; Ischemic Heart Disease; Acute Coronary Syndrome

Summary: the study was a multicenter, two-arm, parallel, open label, prospective study intended for to compare effect of offline community hospital intervention on adherence to drugs and risk factors control in patients with stable coronary artery disease compared with tertiary a-level hospital wechat-based intervention.

objective: this study is intended for to compare effect of offline community hospital intervention on adherence to drugs and risk factors control in patients with stable coronary artery disease compared with tertiary a-level hospital wechat-based intervention. study design: the study was a multicenter, two-arm, parallel, open label, prospective study that evaluated a wechat-based intervention offered by tertiary a-level hospital with 1 year of follow-up. study intervention: all patients received lifestyle intervention and drug adjustment at 1 month, 3 months, 6 months and 1 year follow-up. in the control group, the subsequent visit was through an offline outpatient clinic at 4 different community hospitals. participants in this group received standard outpatient cardiology follow-up with formal cardiac rehabilitation and secondary prevention. while in the intervention group, the subsequent visit was through wechat-based online consultations. outcome measures: the primary outcome was macce. secondary outcome included blood pressure, heart rates, smoking cessation, drinking cessation, body mass index, and medications adherence. statistical analysis: values of analyzed endpoints between intervention group and control group will be compared according to the analysis plan. we'll follow a prespecified analysis plan and subgroup analysis will be conducted accordingly.

Eligibility criteria:
inclusion criteria: 1. aged between 18-99 years 2. diagnosed with scad according to guidelines by coronary cta or coronary angiography (including stable angina, ischemic cardiomyopathy, and the stable course after acute coronary syndrome) 3. have sufficient chinese language proficiency to reading, speaking and listening 4. live with at least one caregiver or guardian in the household 5. presence of stable hemodynamics without using vasopressor 6. able to individually consent 7. not participating in any other clinical trial exclusion criteria: 1. unable to provide informed consent 2. unable to be involved in clinical follow up and treatment 3. suffered comorbidity with a life expectancy of less than 1 year 4. have contra-indication to cardiac rehabilitation 5. acute coronary syndrome
increasing medical student well-being through gratitude journaling

Conditions: Stress, Psychological

Summary: clerkship causes significant stress to medical students. some interventions to increase well-being have been described but none have been studied prospectively in this context. the primary objective of this study is to examine the effects of gratitude journaling on medical clerks' perceived well-being. students will be randomised to one of two groups: gratitude journaling or no intervention. the participants of the experimental group will be asked to complete an online gratitude journal 3 times per week and will be compared to the participants in the control group. the students in both groups will answer a standardised questionnaire evaluating well-being before and after their surgical rotation. those randomised to the intervention group will perform gratitude journaling three times a week during their surgical rotation. this activity consists of writing something that made them feel happy during their day. those randomised in the control group (no intervention) will proceed with their normal rotation, without additional gratitude journaling. the main outcome will be evaluated by comparing the well-being at the end of the surgical rotation as evaluated by a composite well-being assessment scale between both groups.

medical education involves 2 years of rotations in different medical and surgical specialties. these cause significant stress to clerks, in particular during the surgery rotation. in other professional fields, mindfulness techniques have shown only small to moderate effect on mental health compared to the control group. an alternative approach to increasing well-being is gratitude journaling. a study examining this approach in student populations demonstrated enhanced well-being and life satisfaction. the primary objective of this study is to examine the effects of gratitude journaling on medical clerks' perceived well-being. students will be randomised to one of two groups: gratitude journaling or no intervention. the participants of the experimental group will be asked to complete an online gratitude journal 3 times per week and will be compared to the participants in the control group. the students in both groups will answer a standardised questionnaire evaluating well-being before and after their surgical rotation. those randomised to the intervention group will perform gratitude journaling three times a week during their surgical rotation. this activity consists of writing something that made them feel happy during their day. those randomised in the control group (no intervention) will proceed with their normal rotation, without additional gratitude journaling. the main outcome will be evaluated by comparing the well-being at the end of the surgical rotation as evaluated by a composite well-being assessment scale between both groups.

Eligibility criteria:
inclusion criteria: * medical students at the university of montreal about to begin their surgical clerkship rotation. exclusion criteria: -

Keywords: stress medical education
low-level laser therapy with a 635nm diode laser on orthodontic mini-implants stability.

Conditions: Malocclusion, Angle Class II

Summary: the study aimed to clinically estimate an influence of a 635nm diode laser on the primary and secondary stability of orthodontic mini-implants placed in a maxilla, to assess mini-implants failure rate (mini-implant loss) and to evaluate a pain level after the treatment. the randomized clinical split-mouth trial included 15 subjects, 30 implants (dual top anchor system, seoul, korea) with a diameter 1.4mm and length of 10mm. mini-implants were placed in the area of the attached gingiva between the second premolar and first molar teeth 2 mm below the mucogingival junction of both sides of the maxilla in 20 patients (13 women and 7 men; age: 32.5 ± 6.1 years).


Eligibility criteria:
inclusion criteria: * patients with class ii malocclusion defect requiring lateral maxillary teeth distillation based on the use of orthodontic mini-implant; * the patients were treated first time using fixed orthodontic appliance; * no systemic diseases; * were not using anti-inflammatory drugs; exclusion criteria: * had used antibiotics in the previous 24 months; * smokers; * had history of radiotherapy, * taking bisphosphonate medication

Keywords: atp, biostimulation, micro-screw, periotest, semiconductor laser
fibrin sealant in preventing fluid build up during surgery in patients undergoing breast reconstruction

Conditions: Breast Cancer; Perioperative/Postoperative Complications

Summary: the purpose of this study is to investigate the efficacy of an alternative surgical technique and the use of fibrin sealant in preventing post-operative seroma formation. a seroma is a build-up of clear bodily fluids in a place on the body where tissue has been removed by surgery. seromas can happen after breast surgeries. seromas can appear about 7 to 10 days after surgery, after the drainage tubes have been removed. the breast area involved in the surgery may have a spot that's swollen and feels like there is liquid under the skin

primary objectives: i. to evaluate differing surgical techniques (sharp dissection v. electrosurgical, use of fibrin glue) in latissimus dorsi donor flap harvest and their effect, if any on the prevention of post-operative seromas. outline: patients are randomized to 1 of 2 treatment arms. arm i: patients undergo sharp dissection technique with fibrin sealant closure. arm ii: patients undergo standard electrocoagulation dissection technique. after completion of study treatment, patients are followed up for 90-180 days.

Eligibility criteria:
inclusion criteria: * patients who will be undergoing latissimus dorsi donor flap harvest reconstruction and evaluated by the department of plastic and reconstructive surgery at oregon health and science university (ohsu) * these patients will be undergoing reconstructive surgery for a mastectomy/wide local excision of breast cancer defect or other soft tissue defect resulting from trauma, infection, undesirable surgical outcome, oncologic resection, etc. * ability to understand and the willingness to sign a written informed consent document exclusion criteria: * patients who will not qualify for latissimus dorsi donor flap reconstruction based on anatomical limitations specific the subjects respectively; to be evaluated by the plastic surgeon * history of allergic reactions attributed to compounds of similar chemical or biologic composition to fibrin glue sealant * patients with evidence of hematological disorders resulting in deficient coagulation whereby sharp dissection would result in undesirable bleeding otherwise performed more safely with electrosurgery
breathing counts: evaluating adherence in the presence of asthma navigation support

Conditions: Asthma

Summary: to determine if an asthma navigator is helpful in improving communication between care providers and improving patient adherence to asthma medications after an asthma exacerbation.

this study will aim to use technology to evaluate the effectiveness of a patient navigator for childhood asthma. the investigators will place adherence monitoring devices on patient inhalers, and track use of patient asthma medicines. the investigators will also utilize an asthma navigator who will discuss adherence with families and help to address any barriers to adherence that families identify. additionally, the navigator will communicate patient specific adherence information to the patient's primary care physician (pcp) and school nurse. the adherence monitor will monitor communications between these providers.

Eligibility criteria:
inclusion criteria: * age 6-17 years old, * admission to children's hospital colorado with an asthma exacerbation between jan 1 2017 and dec 31 2017. exclusion criteria: * language other than english or spanish (application for monitoring adherence is only available in these languages) * presence of other complex medical problems including: * cystic fibrosis, * tracheostomy/ventilator dependence, * other severe chronic lung disease, and * significant developmental delays. * home schooled or not in school * following up with an allergy or pulmonary provider outside the chco system after hospital discharge.