Kornimate/medical-research-clean huggingface dataset:
the safety and effectiveness of low and high carbohydrate diets

Conditions: Obesity

Summary: this study will compare the safety and the effectiveness of a low carbohydrate diet (atkins diet) with a high carbohydrate diet (conventional usda diet).

despite the considerable mass appeal of popular diet books, such diet approaches lack data to support their efficacy and safety. despite its widespread use for more than 30 years, the atkins diet has never been evaluated in a large, randomized, controlled trial. this study will assess the short-term and long-term clinical effects of a low-carbohydrate diet and a high-carbohydrate diet in overweight and obese men and women. participants in this study will be randomly assigned to the atkins diet (low-carbohydrate, unlimited fat and protein) or a conventional usda diet (high-carbohydrate, low-fat). the study will evaluate the effects of each dietary approach on changes in: 1) weight and body composition; 2) metabolic and organ function; and 3) exercise tolerance. each participant will be enrolled in the study for 2 years.

Eligibility criteria:
inclusion criteria * body mass index between 30 and 40 * live and work within 1 hour of the study site * stable psychological status exclusion criteria * history of heart disease, heart attack, or stroke * blood pressure \>140/90 mmhg * abnormal cholesterol levels * significant psychiatric illness * any medication that affects weight or metabolic rate * presence or history of a chronic disease that is known to affect appetite, food intake, or metabolism (i.e., diabetes, thyroid disease, or cancer) * currently using antidepressants, steroids, tobacco, or illegal drugs * pregnant, breastfeeding, or planning pregnancy * 10 lb change in weight within 6 months of study entry * history of malignant arrhythmias or cerebrovascular, renal, or hepatic disease * history of protein wasting diseases or gout * severe arthritis * osteoporosis * certain types of hormone replacement therapy * currently following a vegetarian diet

Keywords: weight loss
intraoperative perfusion patterns of the sigmoid colon during elective open abdominal aortic aneurysm repair

Conditions: Abdominal Aortic Aneurysm

Summary: blood supply to the sigmoid colon during open abdominal aortic aneurysm (aaa) repair is at risk. ischemia of the sigmoid colon after aaa repair is potentially devastative. no reliable measures to prevent it are available and the underlying mechanisms are poorly understood. the aim of this study is to describe intraoperative perfusion patterns of the sigmoid colon during open aaa repair and their potential impact on postoperative outcome.


Eligibility criteria:
inclusion criteria: * undergoing elective open aaa repair between 2013 and 2016 were eligible for this study exclusion criteria: * no informed consent * emergency cases
cholinergic anti-inflammatory pathway in prevention & treatment of the sirs in patients with jaundice after operation.

Conditions: Systemic Inflammatory Response Syndrome; Jaundice, Obstructive

Summary: rationale:anticholinesterase drugs and cholinergic m receptor antagonist are applied to patients who have obstructive jaundice after operation. purpose:this clinical trial was designed to lower the incidence and mortality of operation complications in patients with obstructive jaundice .

objectives: ⅰ.judge whether it has the effect of inhibiting inflammation, anti oxidative stress and anti apoptosis when the alpha 7 nicotinic acetylcholine receptors are activated . ⅱ.judge whether it has the effect of reducing the incidence and mortality of operation complication when using cholinesterase inhibitors and m cholinergic receptor blocking agent in patients with obstructive jaundice after operation。 outline:patients are assigned to 1 of 2 groups according to order of enrollment. group 1:patients receive neostigmine methylsulfate and raceanisodamine hydrochloride on days 0,1,2 after operation. group 2:patients do not receive any special treatment after operation. all patients should be monitored the observed indexes on the day before the operation and one day, three days, five days after the operation.

Eligibility criteria:
inclusion criteria: ⅰ.accompanied by obstructive jaundice and plans to implement the liver resection of hilar bile duct carcinoma. patients with carcinoma of head of pancreas and plans to implement pancreaticoduodenectomy. ⅱ. drugs which were used in the clinical trials is safe for patients. ⅲ.the patients did not occur the complication which would affect the experimental observation seriously after the operation. ⅳ.the patients agreed to participate in this clinical trial and sign the informed consent. exclusion criteria: ⅰ.patients are unwilling to accept the clinical trials or researchers believe that patients can not in compliance with the requirements of clinical research. ⅱ.patients with tumor metastases widely or can not accept a predetermined operation scheme. ⅲ. the postoperative complications or other therapeutic measures take will affect the experimental observation seriously.

Keywords: systemic inflammatory response syndrome jaundice, obstructive anti-inflammatory
molyf : bone marrow and follicular lymphoma

Conditions: Lymphoma, Follicular

Summary: this is a prospective single-center study designed to assess potential differences in cell composition between bone marrows of patients with follicular lymphoma and those from control subjects. follicular lymphoma is the most common indolent lymphoma. it is characterised by systematic relapses and bone marrow dissemination in 70% of patients at the time of diagnosis. although relapses are thought to be related to refractory tumour cells nested in a supportive microenvironment in the bone marrow, the mechanisms involved are poorly understood. to study the specificities of the bone marrow of patients with follicular lymphoma, it is necessary to compare them with control samples. this study takes advantage of surgeries involving sternotomies to recover lost bone marrow and establish a bone marrow bank of patients without hematological disease. this bank will be used to set up control cohorts for other clinical trials involving patients with follicular lymphoma.


Eligibility criteria:
inclusion criteria: * major patient * patient hospitalized in the thoracic, cardiac and vascular surgery department for surgery involving a sternotomy * patient with free, informed, written consent * patient covered by a health insurance scheme exclusion criteria: * history of haematological malignancy or haemogram disturbance * immunomodulating treatment: immunosuppressants, corticoids, antineoplastics * persons covered by articles l. 1121-5 to l. 1121-8 and l. 1122-1-2 of the french public health code (e.g. minors, protected adults, etc.)\].
effects of consent methods performed according to intelligence types on anxiety associated with third molar surgery

Conditions: Dental Anxiety

Summary: the aim of this study is to investigate the effect of information provided in accordance with intelligence type on anxiety associated with wisdom tooth surgery.

the participants who will undergo third molar surgery divided into study and control groups. study group divided further into three groups according to multiple intellegence test. ultimately four groups created as follows; 1. control: the group with standard (written and verbal) information without multiple intelligence test 2. visual/spatial: the group with higher visual intelligence according to the multiple intelligence test results and watch video. also, will given with a written informed consent document. 3. verbal/linguistic: the group with higher verbal/linguistic intelligence according to the multiple intelligence test results and verbally informed in detail about the operation. lso, will given with a written informed consent document 4. bodily/kinesthetic: the group with higher bodily/kinesthetic intelligence according to the multiple intelligence test results and informed with a dental model. lso, will given with a written informed consent document to evaluate anxiety; participants will asked to complete mdas questionnairre before and after consent, and after operation. also, saliva samples will obtained to evaluate the salivary cortisol before and after consent, and after operation.

Eligibility criteria:
inclusion criteria: * patients with mandibular third molar tooth in vertical or mesioangular position according to winter classification, class i and ii ramus relationship according to pell-gregory classification and class b and c depth * patients who maintain their normal sleep patterns, * patients with asa i status according to the american society of anesthesiologists (asa) classification. exclusion criteria: * patients did not agree to be a volunteer, and/or refused to watch videos or receive information in a different way from the standard procedure, * habits of smoking and alcohol * patients who are pregnant or in the lactation period, * patients unable to cooperate, * patients having a psychiatric illness, * patients with systemic disease (local or systemic factors affecting salivary gland function, can cause changes in endocrine response) * patients using chronic medication and drugs that affect salivary cortisol levels, such as androgens, estrogens and corticosteroids. * patients with pericoronitis
early identification of patients presenting a first psychotic episode, non answering to first line support strategies

Conditions: Schizophrenia

Summary: researchers propose in this project to evaluate predictive factors of non response. it is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis. it will be performed on objective markers taken from imagery techniques. the link between evolution of these markers and clinical measures will be studied.

recently, radiological markers demonstrated a good capacity to discriminate first episode of psychosis patients, that will show a bad response to treatment. furthermore, automatic learning methods were recently successfully applied to neurological data, but never for the first episode psychosis patients. these powerful methods are based on multivariate analyses allowing the prediction at an individual stage. the possibility to identify more precisely the population of non-answering patients would allow the adaptation of the support in first attention for these patients, and consequently to perform appropriate cares. researchers propose in this project to evaluate predictive factors of non response. it is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis. it will be performed on objective markers taken from imagery techniques. the link between evolution of these markers and clinical measures will be studied.

Eligibility criteria:
inclusion criteria: * men and women aged 18-35 years * member or beneficiary of a social security scheme, * for women, appropriate contraception will be mandatory, as well as a negative pregnancy test, * patients with a diagnosis of schizophrenia, schizoaffective disorder or schizophreniform disorder according to the dms v * having never received anti-psychotic treatment, * followed in the hospital or outpatient, * having given their written informed consent, * that the physical examination revealed no significant clinical abnormalities exclusion criteria: * female patients of childbearing period without effective contraception (oral, intramuscular hormonal, intrauterine device, or surgical); * patients pregnant or nursing; * presenting a serious somatic or neurological disease, especially parkinson's disease, epilepsy, debilitating tardive dyskinesia, cardiovascular disease, severe liver or kidney; * featuring against-indication for an mri; including: metallic foreign body eye or intracranial, pacemaker, heart valve, surgical clips, claustrophobia, large tattoo in the upper part of the body, not compatible with 3t mri * having a history of alcohol or drug abuse in the past year; * participating in another clinical trial or being in an exclusion period of the previous protocol; * patients likely to exhibit aggressive behavior self according to the judgment of the investigators.
virtual reality headset and/or aromatherapy for patients undergoing a transperineal prostate biopsy

Conditions: Prostate Cancer

Summary: the purpose of this study is to evaluate if a vr headset and/or aromatherapy can be used to reduce patient pain, anxiety, and embarrassment during a transperineal biopsy (tpbx) compared to standard of care (soc). the primary objective is to evaluate differences in self-reported pain, fear, or embarrassment during and after the procedure between the vr group, aromatherapy group, vr+aromatherapy group, and the control group.

this is a single-center, randomized controlled trial comparing the use of a virtual reality (vr) device vs. an aromatherapy patch vs. vr+aromatherapy vs. standard of care as a non-anesthetic pain management tool during a transperineal prostate biopsy (tpbx). 208 patients who express interest in participating in the trial will be consented via redcap. patients will be centrally, dynamically randomized in a 1:1:1:1 ratio to one of the treatment groups or control group. there will be no subgroup stratification. the randomization will be predetermined by participant id number. there will be a sealed envelope prepared and labeled with the participant id that will contain the information for which treatment group a participant is assigned to. once a participant is consented and assigned an id, the envelope will be reopened to reveal which intervention the patient will be assigned to. all participants will take a survey immediately following the procedure and that will conclude their participation in the study.

Eligibility criteria:
inclusion criteria: * patient is 18 years or older * patient is male * patient is due for a transperineal prostate biopsy * patient signed and dated informed consent form on redcap agreeing to participate in the study exclusion criteria: * patient has a known psychiatric or mental illness that would impede use of the vr device or aromatherapy patch * patient has severe hearing or vision problems that would impair use of the vr headset (under the physician's discretion) * patient has a history of seizures or epilepsy or is on a medication that would lower the threshold for a seizure * patient has a history of reactions to noxious odors

Keywords: transperineal prostate biopsy
profile of pediatric patients admitted to au icu

Conditions: Critical Illness

Summary: this study aims to determine the profile and outcome of children admitted to icu at assiut university children hospital in order to detect association between risk factors and outcome, to asses the efficacy of treatment making it possible to take better decisions , to improve the quality of care.


Eligibility criteria:
inclusion criteria: * all patients admitted to intensive care unit of assiut university children hospital over one year aged from 1month to 18 years exclusion criteria: * pediatric patients less than one month old pediatric patients will die on arrival
a cross-sectional study on ibs subtypes, chinese medicine pattern and host-gut microbiota metabolic interactions

Conditions: Irritable Bowel Syndrome

Summary: the investigators will conduct a cross-sectional study to discovery the distribution of ibs subtypes who would like to seek tcm treatment and their tcm patterns. at the same time, the investigators will also collect the serum, urine and stool samples of the participants to explore the host-gut microbiota metabolic interactions associated with ibs subtypes.

it is a cross-sectional study to discovery the distribution of ibs subtypes who would like to seek cm treatment and their cm patterns.serum, urine and stool samples of the participants will be collected from 400-600 ibs participants to explore the host-gut microbiota metabolic interactions associated with ibs subtypes. the primary outcome will be the distribution of ibs subtype and their cm pattern in hong kong population. secondary outcomes will be the host-gut microbiota metabolic interactions associated with ibs subtypes, the relationship between cm pattern and their microbiota and metabolic profiling. the relationship between ibs subtype distribution and other predetermined factors will be assessed, including gender, age, weight, body mass index (bmi), dietary habit, education, economical status, the overall and individual ibs symptom severity scale (ibs-sss), syndrome of chinese medicine, qol assessment and bristol stool scale.for those who had fulfillment of the structured clinical interview for dsm-5 disorders-(scid-5), the hamilton depression rating scale (hamd-17), clinical global impression-severity (cgi-s), and self-rating depression scale (sds) will also be assessed. after the collection of serum, urine and stool samples, bacterial total dna will be extracted, purified,concentrated,dried and stored for further fecal 16s rrna sequencing analysis. a number of parameters, including serum alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphate (alp) et al., will be measured in serum. total ba and ba profiles in serum and feces will be tested as well.

Eligibility criteria:
inclusion criteria: * 1) meet of diagnosis of ibs(rome 4); 2) age of 18 to 65 years (inclusive); 3) ibs symptom severity scale \[17\] (ibs-sss) \> 75 points (a range of 0-500 points of vas on five questions) at baseline and during the 2-week run-in period; 4) normal colonic evaluation (colonoscopy or barium enema) within 5 years; 5) written informed consent. exclusion criteria: * 1) pregnancy or breast-feeding; 2) medical history of inflammatory bowel diseases, carbohydrate malabsorption, hormonal disorder, known allergies to food additives, and/or any other serious diseases; 3) having suicidal ideas or attempts or aggressive behavior; 4) use of medications known to influence gastrointestinal transit.
strongwomen- healthy hearts: a community based program for midlife and older women

Conditions: Cardiovascular Diseases; Overweight and Obesity

Summary: cardiovascular disease (cvd) is the leading cause of death for women in the united states. cvd disproportionately affects underserved populations, specifically low-income, minority, and rural women who have higher obesity rates and experience other health disparities. there is a need for replicable, evidence-based programs that target women, particularly midlife and older women who represent an increasing proportion of the u.s. population, to reduce their cvd risk . strongwomen - healthy hearts is a 12-week, community-based program that has demonstrated effectiveness at improving cvd risk factors, including body weight, diet quality, and physical activity in a controlled, randomized trial conducted with midlife and older overweight and obese subjects in arkansas and kansas. the central objective is to rigorously evaluate dissemination of the strongwomen - healthy hearts program using the re-aim framework to achieve maximal public health impact. expanded dissemination will occur through the cooperative state research, education and extension service (csrees) this partnership will leverage a long and successful collaboration between tufts university and csrees that provides strength training programs to older women in 41 states.


Eligibility criteria:
inclusion criteria: * greater than 40 years of age * female * bmi greater than 24 * sedentary (not doing any type of exercise more than once per week) exclusion criteria: * unstable medical condition that would preclude participation in an exercise program * current participation in another lifestyle modification program * cognitive impairment * pregnancy.

Keywords: exercise healthy eating heart disease prevention & control middle aged women health promotion
predictive value of periodic repolarization dynamics in post-infarction patients

Conditions: Myocardial Infarction

Summary: increased periodic repolarization dynamics (prd) indicate increased risk of death in cardiac patients. this study thoughts to prospectively validate the prognostic value of prd in post-infarction patients.

periodic repolarization dynamics (prd) reflect periodic changes of repolarization instability located in the low-frequency spectral range. level of prd can be assessed using a high resolution surface ecg recorded in the 12-leads of frank leads configuration during resting conditions. increased levels of prd have been associated with sympathetic overactivity and increased risk of mortality in survivors of acute myocardial infarction and patients undergoing a clinically indicated exercise test.

Eligibility criteria:
inclusion criteria: * previous myocardial infarction \>4 weeks * age \>18 years exclusion criteria: * life expectancy \< 1 year due to non-cardiac causes * unable to give informed consent

Keywords: myocardial infarction repolarization instability ventricular fibrillation
could dietary algae affect immunity and viral counts in people with hiv?

Conditions: HIV Infections

Summary: drawing inferences from epidemiologic studies of hiv/aids as well well as cell culture and animal studies of hiv inhibition by algae, we propose algal consumption as one unifying characteristic of countries with anomalously low rates. hiv/aids incidence and prevalence in eastern asia (\<1/10,000 adults in japan and korea), compared to africa (≈1/10 adults) strongly suggest that differences in iv drug use and sexual behavior are insufficient to explain the 1000-fold variation. even in africa, aids/hiv rates vary. spirulina is part of the daily diet for many people living in chad, where prevalence of hiv has remained at less than 4% for more than 20 years. average daily algae consumption in asia and africa ranges between 1 to 2 tablespoons (3 - 13 grams). hiv viral load is the main indicator of infection, however cd4 helper cell counts are most predictive of morbidity and mortality.we hypothesized that the consumption of algae could be important in diminishing the risk of hiv infection, and subsequent progression, possibly by enhancing the immune response.

twelve hiv+ patients not on antiretroviral therapy were clinically evaluated and enrolled in the three-week study. subjects received 10 algae capsules/d. laboratory tests of cd4 counts and hiv rna were performed at baseline, week 1, week 2, and week 3, and then once a month. six subjects continued for between 4 and 14 months. in addition to cd4 lymphocyte counts and viral loads, subjects were evaluated monthly for complete blood counts (cbc), liver profile, basic metabolic panel, and some subjects were evaluated for thyroid function and cholesterol. all subjects completed standard hiv quality of life questionnaires at each clinic visit.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of hiv * able to swallow pills exclusion criteria: * allergy to iodine/seafood * thyroid disease * not taking antiretroviral therapy

Keywords: hiv dietary intervention algae hiv progression algae specific kind
assessing the effectiveness, immunogenicity and safety of meningococcal abcwy vaccine administered to healthy adolescents

Conditions: Meningococcal Disease

Summary: this is extension of the v102_16 study (nct02140762). v102_16e1 is designed to assess the effectiveness of a 3-dose vaccination series of menabcwy, administered according to 0, 2, 6 month schedule, against the same panel of endemic us n. meningitidis serogroup b strains, as measured by enc-hsba assay. the subjects who completed the parent v102_16 study will be invited at the time of their last study visit to participate in this extension study.


Eligibility criteria:
inclusion criteria: * adolescents who completed v102_16 study and received the study vaccines as assigned in the protocol (either two doses of the menabcwy or one dose each of menacwy and placebo). exclusion criteria: * serious, acute, or chronic illnesses. previous or suspected disease caused by n. meningitidis. * history of any meningococcal vaccine administration other than vaccination given in the parent v102_16 protocol.