Kornimate/medical-research-clean huggingface dataset:
an observational clinical study on the construction of an artificial neural network model for icu pneumonia

Conditions: Pneumonia

Summary: to achieve rapid, intelligent and accurate microbiological diagnosis and treatment for icu pneumonia, an artificial neural network model for microbiological diagnosis is established, which depends on many clinical cases and machine deep learning from clinical experts' judgements according to species-specific rapid detection of pathogenic bacteria and other clinical parameter variables of patients.

this study is a prospective single-centre observational study, 600 icu pneumonia patients are expected to be selected as the observation object, and the lower respiratory secretions of patients on d1, d3 and d7 after enrollment are collected for species-specific rapid detection and microbial culture, while the general information of the patients and the clinical information of the corresponding time points on d1, d3 and d7 are collected. two experienced senior physicians were organized to determine whether the microbial results were colonized or infected, and an artificial neural network model for rapid and intelligent diagnosis of pathogenic microorganisms in icu pneumonia will be established and validated through multi-dimensional machine learning.

Eligibility criteria:
inclusion criteria: 1. aged ≥18 years; 2. agreed to obtain lower respiratory specimens for rapid testing of pathogenic bacteria; 3. all were enrolled by an experienced physician who dynamically determined that the microorganisms were in a colonised or infected state; 4. signed an informed consent form. exclusion criteria: 1. pregnant women; 2. lactating women; 3. patients who could not obtain lower respiratory specimens;

Keywords: pneumonia colonization infection artificial neural network model intensive care unit
clinical significance of subclinical myocardial involvement in recovered covid-19 patients using cardiovascular magnetic resonance (r-covid-cmr)

Conditions: Covid19; Viral Respiratory Infection

Summary: this is a prospective cohort study that aims to clinical significance of subclinical myocardial involvement in recovered covid-19 patients using cardiovascular magnetic resonance.

this study aims to: 1. determine the extent of myocardial involvement of covid-19, as assessed by cardiovascular magnetic resonance (cmr), 2 weeks after patient recovery, at 3-month post discharge and at 1-year post discharge. 2. correlate these myocardial characteristics to biventricular structure, function, blood biomarkers of inflammation, clinical symptoms, and functional capacity at all time points. 3. follow up recovered covid-19 patients beyond the end of this study to assess for hard outcomes such as death, heart failure hospitalization, cardiac arrest and ventricular tachycardia/ fibrillation. recovered covid-19 patients and age and gender matched controls subjects will be recruited.

Eligibility criteria:
inclusion criteria: • recovered covid-19 patients definition of recovered covid-19 patient: * covid-19 diagnosis = established by a positive reverse transcription polymerase chain reaction (rt-pcr) for severe acute respiratory syndrome coronavirus-2 \[sars-cov2\] and recovered from covid-19. * recovery = based on two criteria: (1) two negative nasopharyngeal swab rt-pcr results \>24 hours apart and (2) absence of fever and improvement in respiratory symptoms. * recovered non-covid-19 patients with viral respiratory infections confirmed with viral polymerase chain reaction testing and with a confirmed negative covid-19 rt-pcr test. * age and gender matched controls with no cardiac risk factors, not on cardiac medications, no history of myocardial infarction, heart failure or myocarditis, negative covid-19 rt-pcr test and negative covid-19 antibodies test. exclusion criteria: * previous myocardial infarction or myocarditis unrelated to covid-19 infection * history of heart failure unrelated to covid-19 infection * presence of pacemakers or implantable cardiac defibrillators * any contraindication for cmr testing * renal impairment with egfr \<45ml/min/1.73m2 * limited life expectancy \<1 year, for example due to pulmonary disease, cancer or significant hepatic failure * refusal or inability to sign an informed consent. * potential for non-compliance towards the requirements in the trial protocol (especially the medical treatment) or follow-up visits
prospective study of personalized approach to inpatient patients with hyperglycemia

Conditions: Hyperglycemia

Summary: the purpose of this study is to compare the outcomes between hospitalized cancer patients with high blood sugar receiving the current standard of care of administering insulin, and hospitalized cancer patients receiving a new, individualized method of insulin administration.


Eligibility criteria:
inclusion criteria: * provision of signed and dated informed consent form * stated willingness to comply with all study procedures and availability for the duration of the study * provide race and ethnicity information * male or female, aged 18 years or greater * diagnosed with cancer * hospitalized at mcc in the medical, hematologic, or bone marrow transplant units * having in-hospital hyperglycemia with or without a pre-existing diagnosis of dm, with 2 measurements of bg \> 180 mg/dl and/or 1 measurement of bg \> 350mg/dl within the first 72 hours of admission, detected by bedside point-of-care testing and/or basic metabolic panel laboratory data. * participants enrolled in other clinical trials are admissible to this trial. exclusion criteria: * an individual who meets any of the following criteria will be excluded from participation in this study: * participants \< 18 years of age * participants at the end of life and/or with limited life expectancies (\< 6 months) * participants without cancer diagnoses * surgical patients and patients admitted directly to the intensive care unit, other than those in the bone marrow transplant unit, who are included * participants treated and discharged in outpatient settings (ie, direct referral center, infusion center, or clinical research unit) or those admitted for observation only (hospitalized less than 24 hours) * participants on total parenteral nutrition * participants on insulin pumps * participants admitted with diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome * pregnant participants based on medical history * participants being followed by endocrinology for hyperglycemia or hypoglycemia

Keywords: high blood sugar high blood glucose
survival with own liver of conventional versus laparoscopic kasai for biliary atresia

Conditions: Biliary Atresia

Summary: this study evaluated laparoscopic (videosurgery) versus conventional (open surgery) kasai portoenterostomy (anastomosis of small intestine to the liver hilus) in children with biliary atresia. the study was stopped due to lower survival with native liver 6 months after the laparoscopic operation. follow-up after 24 months confirmed superior results after conventional operation.

objective: a prospective observational study to compare survival with own liver in laparoscopic versus conventional kasai portoenterostomy in patients with biliary atresia. summary background data: available studies on laparoscopic versus conventional kasai portoenterostomy focus on short-term results, include limited numbers of patients and have design limitations. methods: a consecutive series of patients underwent laparoscopic kasai procedure from 2006 to 2007. conventionally operated control patients consisted of a consecutive series of infants with biliary atresia operated from august 2003 to 2006. all data were ascertained prospectively using the european biliary atresia registry / ebar registration forms. primary outcome measure was survival with own liver 6 months after kasai without being listed for liver transplantation. an interim analysis was planned after data became available for the first 12 patients who underwent laparoscopic kasai procedure. in case of a significantly different interim outcome the follow-up period should be extended to 24 months until a final decision should be drawn.

Eligibility criteria:
inclusion criteria: * biliary atresia exclusion criteria: * \< 3000 grs. body weight * syndromatic form of biliary atresia * significant comorbidity i.e. cardiac * contraindication to laparoscopy

Keywords: biliary atresia - laparoscopy - kasai - portoenterostomy
suprascapular nerve block for treatment of shoulder pain in individuals with spinal cord injuries

Conditions: Chronic Shoulder Pain

Summary: the purpose of this study is to evaluate the effectiveness and safety of using suprascapular nerve block for individuals with chronic spinal cord injury who have chronic shoulder pain.


Eligibility criteria:
inclusion criteria: 1. male or female, 18-70 years of age, inclusive. 2 neurological impairment secondary to sci that occurred at least twelve (12) months prior to the screening visit; neurological level of injury between c6 and l5, inclusive. 3. non-ambulatory, except for exercise or therapy purposes. 4. uses a manual wheelchair. 5 history of chronic shoulder pain for ≥6 months that has been unresponsive to conservative treatment (e.g. physical therapy, pharmacological agents), and is rated as ≥4 out of 10 on an 11-point numeric rating scale (nrs) (0 = "no pain"; 10 = "most intense pain imaginable") for average shoulder pain intensity during the week leading up to the screening visit. 6. able and willing to comply with the protocol. 7. able to give voluntary informed consent prior to the performance of any study-specific procedures. exclusion criteria: 1. contra-indications to the procedure (e.g. infection, coagulopathy) 2. history of active cancer within 5 years 3. adhesive capsulitis 4. prior history of regenerative medicine intervention 5. glucocorticoid injection within the past four weeks 6. any medical condition, including psychiatric illness, which would interfere with the interpretation of the study results or the conduct of the study

Keywords: overuse shoulder syndrome
the pathogenesis of depression - possible autoimmune mechanisms

Conditions: Depression; Autoimmune Diseases

Summary: it has long been claimed that depression, and other psychiatric illness, might be a manifestation of immune dysregulation involving the central nervous system. depression is associated with a significantly increased risk of autoimmune disease compared to those without a history of depression. the increased risk of autoimmune diseases is during the first year following the onset of depression .conversely, up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depressive symptoms. the aggregation of depression and some specific autoimmune diseases may demonstrate shared inherited pathogenesis. the first phase of the study will include patients with the diagnosis of depression. the control group will consist of a healthy population, according to medical records and will be recruited through a recruitment ad and volunteers. in the second phase of the study first and second-degree relatives (parents, siblings, children, grandparents, aunts, uncles and cousins) who are diagnosed with autoimmune disease/s will be recruited. auto-immune diseases will include - rheumatoid arthritis (ra), juvenile idiopathic arthritis jia), seronegative spondyloarthropathies (spa) including inflammatory bowel disease (ibd), psoriatic arthritis (psa), and ankylosing spondylitis. other autoimmune diseases: systemic lupus erythematosus, sjogren' syndrome (ss), systemic sclerosis (ssc), inflammatory myopathies (iim), any overlap of the above including mixed connective tissue disease (mctd), systemic vasculitis (see chapel hill classification criteria). all autoimmune diseases will be confirmed by an expert rheumatologist or an internist. celiac disease, diabetes mellitus type i, autoimmune thyroiditis, autoimmune hepatitis will be confirmed by a gastroenterologist, endocrinologist or an internist.


Eligibility criteria:
inclusion criteria: * patients must meet dsm-5 (diagnostic and statistical manual of mental disorders) criteria for a diagnosis of depression. * sufficient knowledge of the hebrew language * a stabled mental state. if hospitalized, patients are scheduled for discharge based on clinical assessment of psychiatric symptoms. exclusion criteria: * mental co-morbidity.
the effect of cow milk consumption on respiratory symptoms and pulmonary functions in asthmatic and non asthmatic children

Conditions: Asthma

Summary: the investigators hypothesis is that milk consumption, either in the acute phase and through prolonged exposure, does not cause or increase respiratory symptoms or airway inflammation. the investigators aim to objectively prove this by examining respiratory symptoms and signs and objectively measuring parameters of airway inflammation and hyper responsiveness after consumption of cow milk or soy milk substitute.

in this prospective single blinded placebo controlled trial, acute milk consumption will be evaluated. 50 asthmatic and 50 healthy children aged 6-18 will drink 240 ml of cow milk or soy milk substitute. respiratory symptoms by questionnaire and physical examination will be evaluated. airway response and inflammation will be assessed by fraction of exhaled nitric oxide (feno) and spirometry before and after the exposure.

Eligibility criteria:
inclusion criteria: * healthy children * asthmatic children exclusion criteria: * known allergy to cow milk * children had upper / lower respiratory disease in two weeks prior the study. * children who had been treated in systemic steroids in the month prior the study. * intolerant children to cow milk.

Keywords: asthma cow milk pulmonary function testing children mucus
the order effect of acute concurrent exercise on executive function: an event-related potential study

Conditions: Executive Function

Summary: executive function is a high-level cognition which plays an important role in our life. meta-analysis study has demonstrated that acute exercise could improve executive function. however, it is still unclear whether executive function can be enhanced by the concurrent exercise that combines aerobic and resistance exercise. moreover, the sequence of concurrent exercise may result in different blood lactate concentration which may affect executive function. therefore, the purposes of present study are: (1) measuring the order effect of acute concurrent exercise on executive function. (2) measuring whether order effect of acute concurrent exercise on executive function is mediated by blood lactate.

executive function is a high-level cognition which plays an important role in academic performance, career, and interpersonal relationship. meta-analysis study has demonstrated that acute exercise could improve executive function, and also observed similar positive effect through both aerobic and resistance exercise. however, it is still unclear whether executive function can be enhanced by the concurrent exercise that combines aerobic and resistance exercise. moreover, the sequence of concurrent exercise may result in different blood lactate concentration which may affect executive function. therefore, the purposes of present study are: (1) measuring the order effect of acute concurrent exercise on executive function. (2) measuring whether order effect of acute concurrent exercise on executive function is mediated by blood lactate.

Eligibility criteria:
inclusion criteria: 1. no history of psychiatric or neurological disorders 2. no history of cardiovascular disease 3. normal or corrected to normal vision and normal color perception 4. right handed 5. 18.5 \< bmi \< 27 exclusion criteria: 1. diagnosed with epilepsy

Keywords: acute exercise concurrent exercise inhibition cognitive flexibility
dose-ranging study in patients with type 1 diabetes mellitus

Conditions: Type 1 Diabetes Mellitus

Summary: the primary objective of this study was to define the dose leading to desirable efficacy, as measured by the change in hemoglobin a1c (a1c) between baseline and week 12.


Eligibility criteria:
inclusion criteria: * participant had given written informed consent to participate in the study in accordance with local regulations. * adult participants 18 years and older with a diagnosis of type 1 diabetes mellitus (t1d) made at least 1 year prior to informed consent. * participants were being treated with insulin or insulin analog delivered via continuous subcutaneous insulin infusion (csii) or multiple daily injection (mdi). * at the screening visit, a1c had to be between 7.0% and 10.0%. * females of childbearing potential had to use an adequate method of contraception and have a negative pregnancy test. exclusion criteria: * use of antidiabetic agent other than insulin or insulin analog at the time of screening. * use of sodium-glucose cotransporter (sglt) inhibitors within 8 weeks prior to screening. * chronic systemic corticosteroid use. * type 2 diabetes mellitus (t2dm), or severely uncontrolled t1d as determined by the investigator.
a multinational trial of the efficacy of albendazole against soil-transmitted nematode infections in children

Conditions: Infections With Soil-Transmitted Helminths (STH)

Summary: the three major soil-transmitted helminths (sth), ascaris lumbricoides, necator americanus/ancylostoma duodenal and trichuris trichiura are among the most prevalent parasites worldwide. the objective of this multicentre international study is to define the efficacy of a single 400 milligram dose of albendazole (alb) against these three sths using a standardised protocol. the trial will be undertaken among school age children in seven countries - brazil, cameroon, cambodia, ethiopia, india, tanzania (zanzibar) and vietnam - each with a different epidemiologic pattern of infection. a trial of this nature is urgently required because in spite of the wide usage of albendazole over the last 3 decades, there is still no key publication reporting the efficacy of the anthelmintic accurately, and to modern conventional standards, that can act as a central reference for the baseline efficacy. the latter is critically important because albendazole is now being used even more widely, as large scale mass treatment campaigns are being implemented in africa and elsewhere, with the intention of reducing morbidity in children. such large scale usage of a drug risks resistance developing, but resistance cannot be detected unless benchmark values for baseline efficacy are widely known.


Eligibility criteria:
inclusion criteria: * children should be infected with a minimum of 150 eggs/gram of any of the three species of sth (i.e. ascaris or hookworms or trichuris). exclusion criteria: * not willing to participate * unable to give samples for follow up * severe intercurrent medical condition * diarrhoea at first sampling
a comparative study of intrathecal magnesium sulphate & midazolam with epidural ropivacaine for caesarean patients

Conditions: Postoperative Pain

Summary: this study compares whether addition of magnesium or midazolam intrathecally to epidurally administered isobaric ropivacaine improves the quality of blockade, haemodynamics and duration of analgesia post-operatively. 25 parturients were given intrathecal magnesium and rest of the 25 parturients were given intrathecal midazolam combined with 0.75% ropivacaine via epidural route.

magnesium sulphate and midazolam have been used in clinical trials as adjuvants to local anaesthetics via intrathecal and epidural routes and are effective in augmenting the quality of block and prolonging post-operative analgesia. noxious stimulation leads to the release of glutamate and aspartate neuratransmitters which bind to various sub-classes of excitatory aminoacid, including the nmda receptor. intrathecal magnesium potentiates neuraxial anaesthesia by blocking nmda receptors with out causing significant side effects as reported in various studies. intrathecal midazolam produces antinociception at spinal cord-level through benzodiazepine gaba-a receptor complex which are present abundantly in the lamina 2 of spinal cord. midazolam also releases endogenous opioid acting at spinal delta receptors and also enhances adenosine release which also augments analgesia.

Eligibility criteria:
inclusion criteria: * 50 pregnant women * asa-i and ii parturients * weight 50-80 kgs * pre-eclampsia exclusion criteria: * thrombocytopenia * hellp syndrome * parturients on magnesium therapy * foetal distress * parturients on benzodiazepine therapy * patient refusal * contraindications to regional anaesthesia

Keywords: magnesium sulphate intrathecal route midazolam
epidural anesthesia in acute pancreatitis

Conditions: Acute Pancreatitis

Summary: acute pancreatitis is a common urgency with a mortality rate of up to 30% , decreased blood flow in the pancreatic microcirculation. it seems to be the main cause of the pathophysiology of acute pancreatitis. today, there have been many attempts in the management of pancreatitis but no established management seems to be ideal. the epidural block is an anesthetic technique used to provide highly peri and post-operative analgesia, also plays an important role in improving the gastrointestinal vascular perfusion (due to sympathetic blockade that this technique produces) so this anesthetic technique is proposed as an alternative to both clinical treatment as an analgesic for acute pancreatitis.

the main objective of the study is to evaluate the therapeutic effects of epidural block in patients with acute pancreatitis, comparing day hospital stay among patients receiving intravenous analgesic treatment and patients who are undergoing epidural block. it is a (prospective, comparative, longitudinal, experimental, randomized) controlled clinical trial. they include patients who are diagnosed with acute pancreatitis at the naval general hospital of high specialty. two groups were taken by random assignment.

Eligibility criteria:
inclusion criteria: 1. patients with acute pancreatitis 2. patients who agree to participate in the study exclusion criteria: 1. patients who do not agree to participate in the study 2. patients who experience any absolute contraindication to epidural block 3. patients with platelet counts below 80,000 mcl 4. patients with data gastrointestinal or urinary bleeding

Keywords: epidural anesthesia pain management microcirculation