Kornimate/medical-research-clean huggingface dataset:
10-year follow-up after tibial tubercle transposition

Conditions: Anterior Knee Pain Syndrome

Summary: patellofemoral pain is a common complaint especially in young adults. it can be caused by patellar maltracking. part of this is a patella alta. when patellar maltracking is the cause of the problem and conservative therapy fails, surgery, a tibial tuberosity transposition, may be considered. most research has been done in patients with recurrent patella luxation. however, in patients without luxation, research is scarce. it is known that patients with patella alta have an increased risk of developing patellofemoral chondropathy due to increased pressure. with this study, we aim to investigate whether and how a tibial tuberosity transposition in patients with patella alta and no instability affects the degree of patellofemoral chondropathy and patient satisfaction after 10 years. this will allow us to educate patients regarding long-term outcomes better.

anterior knee pain is a common complaint, especially in younger and active adults. an obvious source for anterior knee pain is patellar maltracking, which is often associated with patella alta (a high-riding patella). due to maltracking, the cartilage of the patella can face a greater amount of pressure, which can cause cartilage damage. when conservative treatment fails, a surgical intervention can be considered. one of the surgical options is performing a tibial tubercle transfer (ttt), where the patella is being distalized and medialized. as a result, the improvement in patellar tracking will reduce the pressure on the retropatellar cartilage. the ttt has been proven effective in patients with patellar instability but less is known about patients without instability. specifically, whether these patients face a higher risk of developing retropatellar cartilage damage ('retropatellar chondropathy') due to this intervention is currently unknown. the primary aim of this study is to determine the incidence and the degree of retropatellar chondropathy 10 years after a ttt in patients with anterior knee pain without patellar instability. the secondary aim is to evaluate the long-term patient reported outcomes (proms) 10 years after a ttt in patients with anterior knee pain without patellar instability.

Eligibility criteria:
inclusion criteria: * age between 18 and 80 years * participated in an earlier cohort study * underwent a tibial tubercle transposition between 2012 and 2015 * preoperative mri available exclusion criteria: * no preoperative mri is available * patellar-related surgery after the initial surgery * female patients that are (expecting to be) pregnant

Keywords: tibial tubercle transfer long-term follow-up
application of electronic endoscope in fetal distress

Conditions: Fetal Distress; Fetal Hypoxia

Summary: fetal distress is a common emergency in obstetrics, which refers to the combined symptoms of fetal health and life in utero due to acute or chronic hypoxia, with an incidence of 2.7% to 38.5%. fetal distress is mainly related to abnormal amniotic fluid, umbilical cord entanglement and compression, which is an important reason for the increase of cesarean section rate during delivery. at present, the diagnosis of fetal distress mainly relies on electronic monitoring of fetal heart, and the false positive rate is high. intrauterine pressure catheter has not been widely used because of the little effect of intrauterine treatment and the increase of infection. endoscopy has been widely used in the diagnosis and treatment of various specialties at present, but the diagnosis and treatment during childbirth are still in a blind area. the characteristics of endoscopic visualization provide a new idea for the diagnosis and treatment of fetal distress during delivery, especially for the etiological diagnosis and treatment of umbilical cord factors. the use of intraauterine endoscope during delivery can make up for the defects of intrauterine pressure catheter, realize the visual diagnosis of the causes of fetal distress such as oligoamniotic fluid, meconium contamination of amniotic fluid, umbilical cord compression caused by entangling and true junction, etc. at the same time, it can also improve the intrauterine environment by perfusion of saline for the causes of fetal embarrassment, correct fetal distress, and extend the observation time during labor. it is beneficial to reduce caesarean section during labor.


Eligibility criteria:
inclusion criteria: 1. subjects aged 20-45 years with single pregnancy; 2. intrauterine fetal distress occurs during labor (during the first stage of labor), and the fetal membrane was already broken; 3. fetal heart monitoring category ii, after stopping oxytocin, oxygen inhalation, change of position, intravenous fluid and other measures can not improve; 4. understand the research procedures, be able to follow the procedures of the research protocol, and voluntarily sign a written consent. exclusion criteria: 1. type iii fetal heart monitoring for pregnant women who require emergency c-section 2. pregnant women with gbs positive 3. pregnant women suspected of chorioamniotic infection 4. pregnant women have signs of reproductive system infection (vaginal inflammation, cervicitis, uterine infection) 5. pregnant women suspected of uterine rupture 6. pregnant women with abnormal contractions: excessive strong contractions 7. check the fetus for serious deformities during pregnancy 8. check pregnant women with serious abnormal functions of cardiovascular system, urinary system, digestive system, reproductive system and other organs
vaginal vs. laparoscopic hysterectomy

Conditions: Uterine Fibroids; Uterine Leiomyoma; Abnormal Uterine Bleeding, Unspecified

Summary: hysterectomy for benign indication is one of the most common surgical procedures in women. numerous reviews and guidelines recommend the vaginal approach for benign hysterectomy, but the proportion of laparoscopic (and robotic) hysterectomies is increasing. this study will compare a range of clinical and subjective outcomes of vaginal vs. total laparoscopic hysterectomy. outcomes include operating time, postoperative recovery, return to work as well as cosmesis, quality of life and sexual health.


Eligibility criteria:
inclusion criteria: * benign indication for vaginal hysterectomy (e.g., abnormal uterine bleeding, fibroids, atypical endometrial hyperplasia) * clinical exam indicates vaginal hysterectomy is feasible * no major concomitant surgery * able to complete questionnaires in german exclusion criteria: * uterine malignancy * major concomitant surgery (e.g., for incontinence or prolapse) * clinical exam indicating vaginal hysterectomy not feasible * contraindication for surgery or laparoscopy

Keywords: hysterectomy
maternal stress, milk composition, and preterm neurodevelopment

Conditions: Prematurity

Summary: this study explores the associations between maternal stress, breastmilk composition, and feeding and neurodevelopment for preterm infants in the nicu and at 4 months corrected age.

the proposed study will address our novel hypothesis that maternal stress is associated with feeding outcomes and markers of impaired neurodevelopment for preterm infants and alters human milk and infant gut profiles in ways that affect preterm neurodevelopment. mothers and their preterm infants (28-34 weeks gestation at birth) will be recruited to determine if: (1) variation in postnatal stress among mothers of very preterm infants relates to the total volume or proportion of maternal milk provided to her infant in the nicu and if (2) variation in maternal postnatal stress relates to her preterm infant's neurocognitive status at nicu discharge and 4 months corrected age. this project also involves collection/storage of maternal milk and infant fecal samples for multi-omics analyses. more specifically, the study will address: (3a) is maternal postnatal stress associated with the metabolomic and microbiome characteristics of the infant's gut and/or the milk composition?, and (3b) do milk composition differences relate to infant neurodevelopment? the aims of the proposed study contribute to our overarching research goal, which is to improve neurodevelopmental health for preterm infants by building the health and resilience of the mother-milk-infant triad.

Eligibility criteria:
inclusion criteria: * preterm infant born between 28 0/7 and 34 6/7 weeks' gestation that are medically stable for study procedures * mother of preterm infant meeting criteria and a) 18 to 45 years of age at the time of delivery exclusion criteria: * infants: major congenital anomalies, anticipated death, positive blood culture at birth, hypoxic ischemic encephalopathy, grade iv intraventricular hemorrhage, or plan to transfer care before discharge (35-37 weeks postmenstrual age). * mothers: a) alcohol consumption \>1 drink per week or any tobacco consumption during pregnancy, b) known congenital metabolic, endocrine disease or congenital illness affecting infant feeding/growth
onlay versus sublay mesh in incisional hernia

Conditions: Incisional Hernia

Summary: onlay versus sublay mesh hernioplasty in management of incisional hernia comparative prospective study (short term outcomes)

comparison between short term outcomes (advantages and disadvantages) of sublay and onlay techniques in management of incisional hernia regarding : * short term complications (superficial skin infection, seroma formation , recurrence and chronic abdominal discomfort.) * operative time , hospital stay , difficulty of technique.

Eligibility criteria:
inclusion criteria: * surgically fit patients * patients presented with incisional hernias * age between 18 to 60 years * cicatrized incisional hernia involving both muscle cutting and muscle splitting incisions exclusion criteria: * surgically unfit patients * irreducible, obstructed, strangulated hernias * other ventral hernias that not related to surgical incision. * huge hernias with wide abdominal wall defect and retracted abdominal wall muscles.
the effects of cervical stabilization exercises on pulmonary functions and respiratory muscle strength

Conditions: Neck Pain

Summary: this study aims to assess the effects of stabilization exercises on pulmonary functions and respiratory muscle strength. 42 participants with neck pain enrolled the study.

this study aims to assess the effects of stabilization exercises on pulmonary functions and respiratory muscle strength. 42 participants with neck pain enrolled the study. participants were divided into two groups, stabilization group (n=21) and the control group (n=21). the participants underwent a total of 24 sessions of treatment thrice a week for eight weeks under the supervision of a physiotherapist.

Eligibility criteria:
inclusion criteria: * neck pain longer than 3 months * patients between ages of 18 and 55 exclusion criteria: * patients with neurologic symptoms * patients with chronic pulmonary disease * previous surgery on cervical region

Keywords: neck pain pulmonary function test respiratory muscle strength cervical stabilization exercises
oral health-related patterns of food selectivity in dental populations

Conditions: Oral Disease; Food Selection

Summary: the present study was undertaken in order to describe the clinical profiles of food selective behavior in 35-65 years dental and non-dental populations.

the study population included 125 participants, recruited within the general population and in a dental clinic: -non-dental group included 62 non-seeking dental treatment subjects, aged 30-65 years, previously recruited during the oralpom survey. -dental group included 63 patients recruited from september 2019 to december 2020 among patients seeking/pending dental treatment within the university dental clinic of the rothschild hospital (ap-hp sorbonne university, paris, france). both groups took part in an individual session with a dental practitioner during which food selectivity, medical history, and oral health status were assessed.

Eligibility criteria:
inclusion criteria: * non-dental group : non-seeking dental treatment subjects, aged 30-65 years. * dental group: patients seeking/pending dental treatment within the university dental clinic of the rothschild hospital (ap-hp sorbonne university, paris, france), aged between 35 and 65 years, literate french speakers, willing and able to complete the survey in a single setting. exclusion criteria: * for non dental group :declared painful conditions including temporo-mandibular disorder, cephalalgia, oral or dental pain, diagnosis of acute orofacial disease (i.e. rhinitis) or sensory trouble (i.e. anosmia, dysgeusia) neither at the time of the experiment nor in the recent past, pregnancy, head and neck irradiation, eating disorders, enteral or parenteral feeding, and cognitive impairment or impaired communication. * patients suffering from cognitive impairment or impaired communication are excluded.

Keywords: eating behavior food preferences
evaluate the impact of afatinib on quality of life and symptom burden of greek subjects with advanced nsclc in routine patient care settings

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: this non-interventional study will include a representative sample of patients with locally advanced or metastatic nsclc harboring epidermal growth factor receptor (egfr)-mutations in greece. eligible nsclc patients, for whom the physician has decided to initiate treatment with the study medication (afatinib, giotrif®) will be treated according to the local prescribing information and standard medical practice in terms of visit frequency and types of assessments performed. the study will investigate the impact of giotrif (afatinib) on patients' disease-related symptom burden and health-related quality of life (hrqol) in a real world clinical setting in greece.the average symptom burden index (asbi) score of the lung cancer symptom scale (lcss) in eligible patients, after 6 months of therapy, will be analyzed. the overall study duration period is expected to be 60 months, including a 48-month enrollment period and a minimum 12-month follow-up period.

study design:

Eligibility criteria:
inclusion criteria: * adult outpatients (18 years and older) of either gender; * histologically or cytologically confirmed locally advanced or metastatic (iiib/iv) nsclc of any histological type with activating egfr mutation(s) according to local laboratory egfr testing; * egfr- tyrosine kinase inhibitor (tki) naive patients; * patients for whom the decision to prescribe therapy with afatinib (giotrif®) according to the locally approved product's summary of product characteristics (smpc) has already been taken prior to their enrolment in the study; the assignment of the patient to this therapeutic strategy is not decided in advance by the study protocol but falls within current practice and the prescription of afatinib is clearly separated from the physicians decision to include the patient in the current study; * patients must be able and willing to provide written informed consent and to comply with the requirements of this study protocol; exclusion criteria: * patients who have initiated treatment with afatinib more than 7 days prior to their enrolment into the study; * patients that meet any of the contraindications to the administration of the study drug according to the approved smpc; * receipt of any investigational agent within 30 days or 5 half-lives of the investigational agent (whichever is longer) before the commencement of therapy with afatinib
a randomized control trial of an intervention to reverse frailty and enhance resilience through exercise and education

Conditions: Frailty; Sarcopenia

Summary: resistance training done at home and protein supplementation may be the most effective and easiest to implement interventions to reverse frailty and build resilience. however, it is not common practice to offer and support such interventions in primary care. this study provides an opportunity to assess the effectiveness of an optimised intervention with community-dwelling adults aged 65 and over, whose baseline clinical frailty score is not worse than mild (i.e. 5 or less), evaluate improvements in health outcomes and demonstrate how the intervention may be incorporated efficiently in clinical practice. the results are intended to encourage mainstream adoption of practical interventions to reverse clinical frailty and build resilience in primary care. an intervention with ten recommended resistance exercises and dietary guidance on protein consumption has been derived from findings of our systematic review and meta-analysis and optimised through a patient and public involvement (ppi) process and feasibility study.


Eligibility criteria:
inclusion criteria: * aged 65 or older at baseline * rockwood clinical frailty scale score 4 or 5 (vulnerable or mildly frail) * able and willing to provide informed consent and to comply with the requirements of this study protocol exclusion criteria: * rockwood clinical frailty scale score \> 5 * end of life care * persons in residential care home * concurrent malignancy ckd stage 3 or 4 * coded diagnosis of severe dementia as per gp or consultant geriatrician diagnosis or baseline montreal cognitive assessment (moca) score \<= 10 * persons unable to engage in discussion on frailty due to acute care needs or determined to be inappropriate by gp (e.g., needing transfer to ed or acutely unwell or disorders resulting in intolerance of the intervention) * subjects unable to provide written informed consent

Keywords: resilience primary-care intervention exercise protein diet community
validation of a mental health scale for young people with chronic stomach symptoms

Conditions: Functional Gastrointestinal Disorders; Gastroparesis; Vomiting; Cyclical; Nausea; Vomiting; Rumination Syndrome; Aerophagy; Dyspepsia

Summary: this study aims to validate the alimetry® gut-brain wellbeing survey- youth version (agbw-y), a mental health scale developed for patients aged 12-17 years with chronic stomach symptoms.

there is currently a lack of validated questionnaires developed to assess mental health within patients with chronic stomach symptoms. our team has therefore developed and validated a new mental health scale for patients with gastroduodenal symptoms, the alimetry® gut-brain wellbeing (agbw) survey. however, the agbw survey was developed and validated for patients aged 18 years and over. therefore, the alimetry® gut-brain wellbeing survey- youth version (agbw- y) was developed for use in patients with chronic gastroduodenal symptoms aged 12-17 years. this scale is adapted from the adult agbw survey, with more appropriate wording for this age group. this study will distribute an anonymous, online survey to adolescent patients with chronic gastroduodenal symptoms aged 12-17 years. this survey will ask questions about a patient's general demographics, gastrointestinal symptoms, and mental health in order to assess the validity and reliability of the agbw-y.

Eligibility criteria:
inclusion criteria: * aged 12-17 years * able to read and write fluently in english * meet the rome iv criteria and/or have a self-reported previous clinical diagnosis for at least one of the following childhood gastroduodenal dgbis: gastroparesis, cyclic vomiting syndrome, functional nausea, functional vomiting, rumination syndrome, aerophagia, or functional dyspepsia exclusion criteria: * patients with self-induced vomiting * patients with an eating disorder
the value of palliative primary tumor resection in metastatic colon cancer

Conditions: Metastatic Colon Cancer; Surgery

Summary: the aim of this trial is to evaluate the value of palliative primary tumor resection in colon cancer patients with initially unresectable metastases and a positive response to induction chemotherapy which depends on gene testing. the primary endpoint is to evaluate overall survival.


Eligibility criteria:
inclusion criteria: * 75 years old * ecog (eastern cooperative oncology group) 0-1 and expected survival period for 6 months or more * pathological diagnosis of colon cancer adenocarcinoma * at least one measurable objective tumor lesions which could be evaluated. * primary and metastatic tumors exist at the same time, and distant metastases are not resectable * anc≥1.5\*109/l；plt≥90\*109/l；hb≥90g/l；tbi≤1.5(unl); alt、ast≤2.5uln；cr≤1.0(uln) screening within 7 days * no systemic chemotherapy * patients with voluntary participation, and sign the informed consent exclusion criteria: * operation intervention required for perforation, bleeding and obstruction of intestinal cavity * multiple primary colorectal carcinoma * malignant peritoneal effusion or metastatic carcinoma of the peritoneum * uncontrolled pleural effusion * malignant tumour of the past five years with other organizations to source, but the full treatment of cervical carcinoma in situ and except skin basal cell carcinoma and squamous cell carcinomas * with brain metastasis or meningeal metastasis * pregnancy or breast-feeding women * alcohol or drug addictions * there is an important organ failure or other serious diseases, including coronary artery disease, symptomatic cardiovascular disease or myocardial infarction within 12 months; serious neurological or psychiatric history; severe infection; actively disseminated vascula blood coagulation

Keywords: palliative surgery stage iv colon cancer chemotherapy
tracheal anatomy after thyroidectomy

Conditions: Goiter, Nodular

Summary: the investigators aimed at investigating the effects of thyroidectomy on tracheal anatomy and airflow in patients with benign nodular goiter, employing a prospective observational study. magnetic resonance images of the neck and respiratory flow-volume curves were performed prior to and six months following surgery. tracheal and thyroid volumes, smallest cross-sectional area of the trachea (scat), tracheal narrowing, tracheal deviation and tracheal encirclement by the thyroid were evaluated. through flow-volume curves respiratory function, including both in- and expiration, was evaluated.


Eligibility criteria:
inclusion criteria: * reads and write danish exclusion criteria: * suspected or present malignancy * neuromuscular disease * prior surgery to the neck