Kornimate/medical-research-clean huggingface dataset:
photograph quality rating scale study ("pqrs study")

Conditions: Dermatology/Skin - Other

Summary: advances in smart phone-based photography (both quality and image transmission) offer the potential to greatly improve access to pediatric dermatologists. however, the accuracy of diagnoses reliant on parent-provided photographs has been neither measured nor compared to diagnoses based on in-person examinations. therefore, the primary objective of this study was to assess the concordance between diagnoses based on photographs taken by parents (or legal guardians) and those based on in-person examinations. a secondary aim was to assess the effect of photography instructions on improving this concordance.

each patient/parent dyad will be randomized into one of two approximately equally sized groups; half of the subjects will be provided with an instruction sheet on how best to take photographs of skin conditions with their mobile devices (study group) and half will not be provided this instruction sheet (control group). photographs will be evaluated for image quality and to provide a diagnosis (see attached forms including photograph quality rating scale).

Eligibility criteria:
inclusion criteria: 1. must be a new patient/parent dyad arrived at the main pediatric dermatology clinic 2. patient must be under the age of 18. 3. consenting parent or guardian must be present and able to speak english to participate. 4. patients are either already enrolled in mychop (mychart) or are willing to enroll during the encounter. 5. parent or legal guardian has a mobile phone with the capability to download the free mychart app. 6. parents have a data plan that allows them to download the mychart app (if not already downloaded) and upload pictures, and are willing to accept any potential data charges incurred with these activities. 7. patient has active skin lesion or rash that can be photographed during the clinic visit. exclusion criteria: 1. patient is over the age of 18. 2. parent or guardian is not present or not able to speak english. 3. parent or guardian is not able to enroll in mychop (mychart). 4. parent or guardian does not have a mobile phone capable of downloading the mychart app. 5. photographs are not able to be taken (phone battery dies, phone/app does not work, patient is not cooperative, participant does not have time). 6. if there are no active skin lesions to photograph the patient/parent will not be enrolled (e.g. hives that are inactive, hyperhidrosis \[excessive sweating\], itching without a rash, resolved skin lesions \[e.g. warts, molluscum\]). 7. patients presenting for a general full body skin exam will be excluded, as this would require full body photography, which is too time consuming. (note: this does not include evaluation of one individual mole \[nevus\], which can be included in the study).
study of the safety and efficacy of regn1033 (sar391786) in patients with sarcopenia

Conditions: Sarcopenia

Summary: this is a randomized, double-blind, placebo-controlled, multicenter phase 2 study of the safety and efficacy of 3-month subcutaneous (sc) regn1033 (sar391786) treatment in patients with sarcopenia.


Eligibility criteria:
inclusion criteria: 1. men and women aged 70 years and older (all women participating in the study must be postmenopausal) 2. are capable, in the investigator's opinion, to complete the study per protocol and have no significant health issues or conditions 3. ability to follow a walking program 4. willing and able to comply with clinic visits and study-related procedures 5. provide signed informed consent 6. able to understand and complete study-related questionnaires exclusion criteria: 1. hospitalization or immobilization with a duration of \>48 hours within the month prior to screening 2. surgical procedure requiring general anesthesia within 1 month prior to screening, or a planned surgical procedure requiring general anesthesia within the next 6 months 3. participate in resistance training more than 3 times per week and regular exercise consisting of an average of 30 minutes per day or more of at least moderate physical activity 4. chronic medications introduced within 2 weeks prior to screening 5. respiratory disease that requires oxygen treatment 6. cancer requiring treatment currently or in the past 3 years (except primary nonmelanoma skin cancer or in situ cervical cancer) 7. neurological conditions that are causing impaired muscle function or mobility 8. certain cardiovascular conditions 9. uncontrolled diabetes the information listed above is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial and not all inclusion/ exclusion criteria are listed.
facilitated tucking position, gentle human touch practices and pain

Conditions: Pain; Premature

Summary: this prospective study is planned as a randomized controlled study to evaluate the effect of facilitated tucking position and gentle human touch practices on the pain experienced by newborns during heel blood collection. this study is planned to be carried out between 15 july and 15 december 2023 in the neonatal intensive care unit of a training and research hospital in the southeastern anatolia region. the sample size was calculated based on the study of premature infants to determine the effect of facilitated tucking position on procedural pain. according to the results of the study, pipp pain scores were determined as 11.88±3.05 in the intervention group (n=17) and 9.06±2.95 in the control group (n=17). the effect size of the study was determined as d= 0.939 at α=0.05 level and 95% confidence interval. it was decided to conduct the study with a total of 90 premature babies, 30 of whom were in the groups, in case of data loss during the study.

neonatal pain negatively affects prognosis, behavior, environmental adaptation, development of the brain and senses, and interaction. effective management of neonatal pain supports health and recovery, shortens hospital stays, and reduces care costs and the prevalence of neurobehavioral problems. therefore, proper management of pain in newborns is important for the healthy development of newborns. many invasive procedures are applied to newborns hospitalized in neonatal intensive care units. non-nutritive sucking, oral sucrose, kangaroo care, facilitated tucking position, and gentle human touch have proven to have positive effects on the pain experienced by newborns during interventional procedures. in this study, the effect of facilitated tucking position and gentle human touch practices applied during heel blood collection on the perception of pain in premature newborns will be examined.

Eligibility criteria:
inclusion criteria: * premature newborns (34-37 weeks of gestation), dependent on nasal cpap, without congenital anomalies, not taking sedative or analgesic drugs, not receiving oral feeding, and whose parents approved to participate in the study will be included in the study. exclusion criteria: * newborns with open wounds on their body, bleeding disorders, and those who underwent a painful procedure just before heel blood sampling will not be included in the study.
study of dapagliflozin in combination with metformin xr to initiate the treatment of type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: the primary purpose of this study is to compare the change from baseline in hemoglobin a1c achieved with dapagliflozin 10 mg in combination with metformin xr as compared with metformin xr monotherapy and compared with dapagliflozin monotherapy, after 24 weeks of oral administration of double-blind treatment. the safety of treatment with dapagliflozin will also be assessed in this study


Eligibility criteria:
inclusion criteria: * treatment naive males and females, \>= 18 years old and \<= 77 years old, with type 2 diabetes mellitus * subjects must have central laboratory pre-randomization hemoglobin a1c \>= 7.5 and \<= 12.0% * c-peptide \>= 1.0 ng/ml (0.34 nmol/l) * body mass index \<= 45 kg/m2 * must be able to perform self monitoring of blood glucose exclusion criteria: * aspartate aminotransferase (ast) and/or alanine aminotransferase (alt) \>3x\*upper limit of normal (uln) * serum total bilirubin \>2 mg/dl (34.2 µmol/l) * creatinine kinase \>3\*uln * serum creatinine \>= 1.50 mg/dl (133 µmol/l) for male subjects, \>= 1.40 mg/dl (124 µmol/l) for female subjects * calcium value outside of the central laboratory normal reference range * currently unstable or serious cardiovascular, renal, hepatic, hematological, oncological, endocrine, psychiatric, or rheumatic diseases * urine albumin:creatinine ratio (uacr) \>1800 mg/g (203.4 mg/mmol cr) * severe uncontrolled hypertension defined as systolic blood pressure (sbp) \>=180 mmhg and/or diastolic blood pressure (dbp) \>=110 mmhg * hemoglobin \>=11.0 g/dl (110 g/l) for men; hemoglobin \>=10.0 g/dl (100 g/l) for women * positive for hepatitis b surface antigen * positive for anti-hepatitis c virus antibody * history of diabetes insipidus * history of diabetic ketoacidosis or hyperosmolar nonketotic coma * symptoms of poorly controlled diabetes that would preclude participation in this trial

Keywords: diabetes mellitus, type 2 diabetes mellitus endocrine system diseases glucose metabolism disorders metabolic diseases metformin dapagliflozin hypoglycemic agents pharmacologic actions physiological effects of drugs
a bilateral dispensing clinical trial of an sapphire lens against senofilcon a toric for astigmatism lens

Conditions: Astigmatism

Summary: this study was conducted to evaluate the clinical performance of an investigational silicone-hydrogel lens against senofilcon a toric lens. the study results were not used for design validation of the investigational product.

this will be a randomized, bilateral, 2-week cross-over, double-masked, dispensing study comparing the investigational test lens against the senofilcon a toric for astigmatism control lens.

Eligibility criteria:
inclusion criteria: * a person is eligible for inclusion in the study if they: 1. are at least 18 years of age and have full legal capacity to volunteer; 2. have read and signed an information consent letter; 3. are willing and able to follow instructions and maintain the appointment schedule; 4. are an adapted soft contact lens wearer; 5. require spectacle lens powers in both eyes; 1. sphere: between -1.75 to -6.00 diopters and 2. astigmatism: between -1.00 to -2.25 and 3. axis: 180 ± 20 degrees 6. are willing to wear contact lenses in both eyes; 7. have manifest refraction visual acuities (va) equal to or better than logmar (log of the minimum angle of resolution) equivalent of 20/25 in each eye; 8. to be eligible for lens dispensing, the subject must have va of logmar equivalent of 20/30 or better in each eye with the study lenses and the investigator must judge the fit including toric orientation as acceptable. exclusion criteria: * a person will be excluded from the study if they: 1. are participating in any concurrent clinical or research study; 2. have any known active\* ocular disease and/or infection; 3. have a systemic condition that in the opinion of the investigator may affect a study outcome variable; 4. are using any systemic or topical medications that in the opinion of the investigator may affect a study outcome variable; 5. have known sensitivity to the diagnostic pharmaceuticals to be used in the study; 6. are pregnant, lactating or planning a pregnancy at the time of enrolment (by verbal confirmation at the screening visit); 7. are aphakic; 8. have undergone refractive error surgery;
epidemiological study of fabry disease in taiwan young stroke patients

Conditions: Fabry Disease

Summary: epidemiological study of fabry disease in taiwan young stroke patients

this is a cross-sectional, population-based study. no randomization procedure will be executed in this study. approximately 1000 subjects over a 36-month period. the aim of this screening study is to identify the fabry disease as the cause in patients with young stroke. to measure the level of α-gal a activity, male subjects will initially provide a dbs sample and female subjects will start with a test by whole blood sample. the prevalence of fabry disease among patients with young stroke will be estimated by a confirmative diagnosis in gene testing.

Eligibility criteria:
inclusion criteria: * patients aged 20 or over * patients aged under 56 years old, not included 56 * patients with acute stroke * patients and/or their legal representatives are willing to provide written informed consent exclusion criteria: * patients with a confirmed diagnosis of fabry disease

Keywords: fabry disease young stroke
evaluation of the prevalence of oral hpv infection in patients who are positive to the pap-test

Conditions: HPV Infection

Summary: the present cross-sectional study aims to assess the prevalence and type distribution of oral hpv infection in pap-test-positive women aged ≥18 years. the means used in the present study will be the use of anamnestic questionnaires and exfoliative cytology tests at predetermined oral mucosal sites (lingual belly and dorsum, palate, and buccal mucosa).

the present cross-sectional study aims to evaluate the prevalence and distribution of the type of oral hpv infection in pap-test positive women. aged ≥18 years. sociodemographic and anamnestic data will be collected by questionnaire administration. data collected will be age, marital status, number of sexual partners, hpv vaccination, oral sex, contraceptive use, systemic diseases, smoking, alcohol consumption, etc.. next, patients will undergo oral cavity inspection and exfoliative cytology testing at predetermined oral mucosal sites (lingual belly and dorsum, palate, and buccal mucosa). sample taken sent for cytological analysis to determine the presence of viral dnaand possible typing.

Eligibility criteria:
inclusion criteria: * female patients with positive pap test; * age ≥ 18 years exclusion criteria: * female patients with negative pap test * uncooperative patients * patients with mental deficits * age\<18 years
crrt for glutamate elimination after cardiac arrest

Conditions: Reperfusion Syndrome

Summary: glutamate is known to be a mediator for apoptosis after brain hypoxia e.g. due to cardiac arrest. this pilot trial evaluates the possibility of elimination of glutamate by crrt after cardiac arrest.


Eligibility criteria:
inclusion criteria: * post cardiac arrest exclusion criteria: * hemodynamic instable * in-hospital cardiac arrest
early detection of neonatal shock

Conditions: Impact of Advanced Hemodynamic Monitoring

Summary: the purpose of this study is to evaluate the hypothesis that advanced hemodynamic monitoring results in an earlier detection of circulatory failure in newborn infants


Eligibility criteria:
inclusion criteria: * birth weight \>700 grams * arterial catheter in place * central venous catheter in place * informed consent from parents/legal representatives exclusion criteria: * life-threatening congenital defects * congenital heart defects, except patent ductus arteriosus and patent foramen ovale

Keywords: newborn shock hemodynamics cardiac output blood pressure
contrast-enhanced magnetic resonance angiography investigation of intracranial aneurysms and prospective study of risk factors

Conditions: Intracranial Aneurysm

Summary: this is a prospective observational registry with intent to detect the prevalence of intracranial aneurysms with contrast-enhanced mr angiography (ce-mra) at 1.5t, and to determine the risk factors such as high blood pressure and cigarette smoking relating to intracranial aneurysms.

intracranial aneurysms are common and have been reported increased incidence rate because of the widespread use of high-resolution imaging techniques. they are clinically important because of the life-threatening rupture and hemorrhage. early detection and diagnosis is the key of treatment. contrast-enhanced mr angiography (ce-mra), as a simple, sensitivity and noninvasive method, is playing an important role in vascular imaging. ce-mra has been an accuracy modality for intracranial aneurysm at most centers and proved the high sensitivity and accuracy comparing with dsa. therefore, we use ce-mra at 1.5t as a tool of epidemiological investigation of intracranial aneurysms. in retrospective analysis, conventional risk factors for intracranial aneurysms include hypertension, hyperlipidemia, diabetes mellitus (dm), smoking history, and family history, etc. however, retrospective analysis probably gives an underestimation or overestimation of the actual results. prospective analysis will get accurate data on the risk factors relating to intracranial aneurysms

Eligibility criteria:
inclusion criteria: * aged 20 to 80 years * willing to undergo study procedures * who are fully informed about the study and have signed the informed consent form exclusion criteria: * history of intracranial aneurysm * history of intracranial tumor * history of cerebral infarction * acute stroke * require emergency treatment * contraindication for mri examination * severely impaired renal functions * known anaphylactic reaction to mr contrast media * pregnancy or nursing

Keywords: intracranial aneurysm magnetic resonance angiography epidemiology
a machine learning architecture to predict post-hepatectomy liver failure using liver regeneration biomarkers and time-phased data

Conditions: Liver Failure After Operative Procedure

Summary: post-hepatectomy liver failure (phlf) is the leading cause of morbidity and mortality following major hepatectomy. existing prediction models fail to capture the dynamic liver regeneration and perioperative changes, limiting their predictive accuracy. we aimed to develop a machine learning (ml) modelling system (pilot architecture) integrating liver regeneration biomarkers with time-phased perioperative clinical data to accurately predict phlf risk.


Eligibility criteria:
inclusion criteria: extensive hepatectomy in our hospital（≥ three hepatic segment） exclusion criteria: serious basic diseases intolerable surgery refuse to perform icg test before operation
phase ii iressa & carbo/gem in nsclc

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: the primary objective is to demonstrate in chemotherapy naïve patients with advanced (stage iiib or iv) nsclc and ecog ps 2 non-inferiority in progression free survival (pfs) for zd1839 compared to gemcitabine/carboplatin.


Eligibility criteria:
inclusion criteria: * advanced non small cell lung cell lung cancer * never received chemotherapy * up and about 50% of waking hours exclusion criteria: * spread of lung cancer to the brain * low level of white blood cells * radiotherapy within 4 weeks patients were entered to this study, initiated in 2004, before the significance of predictive factors such as smoking history, adenocarcinoma histology and mutation status was described.

Keywords: non-small-cell lung cancer nsclc lung cancer
median nerve strain and applied pressure measurement in the carpal tunnel syndrome patients

Conditions: Carpal Tunnel Syndrome

Summary: the aim of this study is to investigate diagnostic accuracy of median nerve strain and applied pressure measurement . idiopathic carpal tunnel syndrome patients and healthy controls will be evaluated by ultrasound. median nerve strain, pressure applied to the skin will be measured at the proximal part of the carpal tunnel. the parameters will be compared between patients and controls, and before and after the open carpal tunnel release in the patients.

the aim of this study is to investigate diagnostic accuracy of median nerve strain and applied pressure measurement . idiopathic carpal tunnel syndrome patients and healthy controls will be evaluated by ultrasound. median nerve strain, pressure applied to the skin, and ratio of pressure-strain will be measured at the proximal part of the carpal tunnel. in addition, distal latencies in the motor and sensory nerve conductions studies and cross-sectional area of median nerve will be measured. the parameters will be compared between patients and controls, and before and after the open carpal tunnel release in the patients.

Eligibility criteria:
inclusion criteria: * carpal tunnel syndrome patients and asymptomatic control exclusion criteria: * patients were excluded if there was a history of cervical radiculopathy, rheumatoid arthritis, gout, hemodialysis, sarcoidosis, amyloidosis, or traumatic injuries to the arm. written consent was obtained from all study participants
the s-care trial: manual treatment for c-sections scars, a pilot study.

Conditions: Cesarean Section Complications; Cesarean Section; Complications, Wound, Infection (Following Delivery)

Summary: this study aims to examine the effects of an osteopathic treatment on adhesions related to c-sections scars.

the rates of caesarean sections are growing throughout the world, with recent rates (in 2016) in europe of 25%, in north america of 32.3% and in south america of 40.5%. the incidence of intra-abdominal adhesions in women undergoing to repeated caesarean sections is constantly increasing. labor and surgical time are significantly longer in patients with adhesions compared to patients without adhesions. furthermore, it has been estimated that about 10% of patients undergoing cesarean section experience chronic pain. despite of the big impact on the quality of life of patients and high cost for public health, treatments for adhesions are mostly surgical. the identification of non-surgical treatments that aim to reduce cicatricial adhesions' formation is essential to decrease hospitalization times and associated complications. the purpose of this study is to evaluate the effects of osteopathic treatment and self-massage on scars in women who underwent to a cesarean section. the main aim is to assess whether there is a change in the number, size and vascularization of of cesarean section adhesionsthrough superb microvascular imaging (smi).

Eligibility criteria:
inclusion criteria: * primiparous or multipara who have undergone a cesarean section with a completely healed scar will be included. * women who had first menstruation after childbirth * women with or without pain or symptoms related to scarring or the presence of isthmocele will be included. exclusion criteria: * caesarean section performed in a period less than 6 months and over 3 years * uterine prolapse * scar treatments already performed (both manual and medical) * absence of scar adhesions

Keywords: adhesions cicatrix c-section scar manual treatment