Kornimate/medical-research-clean huggingface dataset:
smoking cessation in primary health care patients with obstructive pulmonary disease

Conditions: Smoking; Pulmonary Disease, Chronic Obstructive

Summary: the purpose of this study is to determine if an assessment protocol that measures the need for support with smoking cessation and that will be administered by primary health care nurses helps patients with obstructive pulmonary disease (copd) quit smoking.

some patients with copd continue to smoke despite the importance of quitting. a specially developed assessment protocol for such patients may support nurses in their discussions with the patients about smoking cessation. in a previous qualitative study involving in-depth interviews with patients with copd, the assessment protocol "trying to quit smoking" (ttq) was developed. the protocol consists of approximately 21 statements that the patient responds to on a scale ranging from 1 (agree entirely) to 4 (disagree). the purpose of the protocol is to identify areas in which the patient may need extra support in order to quit smoking. the aim of this study is to validate the ttq by testing it in a clinical setting. the study will be conducted at approximately 40 primary health care centers in stockholm county. the nurses will identify 5 consecutive patients who have copd and smoke. all nurses will complete a questionnaire for each patient at baseline (after visit 1) and after 3 months describing treatment provided. the nurses will ask each patient to fill in the ttq and will provide individual counseling on the basis of the answers. after 3 months, the nurses will ask all patients if they still smoke and to fill in the ttq again. appropriate statistical methods will be used to analyze the questionnaire data.

Eligibility criteria:
inclusion criteria: * physician diagnosis of copd * current smoker * speak swedish well enough to answer the ttq assessment protocol exclusion criteria: * cognitive difficulties that, in the judgment of the participating nurses, would make it difficult for the patient to answer the ttq assessment protocol or benefit from counseling

Keywords: smoking pulmonary disease, chronic obstructive questionnaires nurses primary health care
low fat diet and multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to evaluate if following a specific low fat diet will improve the brain damage as seen by magnetic resonance imaging (mri) and to decrease the progression of multiple sclerosis (ms) as evidenced by clinical evaluation and symptoms.

this research project has significance for its potential to develop a new therapeutic approach to ms. current treatments in ms include disease modifying therapies such as human recombinant interferon beta, glatiramer acetate and natalizumab. however, these are only partially effective, cannot be taken orally, have side-effects and are very expensive. developing treatment that can be combined with current disease modifying agent remains an important goal for improving the care of people with ms.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of the relapsing-remitting form of ms * age 18-70, inclusive * ms duration of less than 15 years * may or may not be on disease-modifying therapies for ms, but if on, must be on for more than 6 months of continuous therapy * should not have diabetes * able and willing to follow exercise instructions * able and willing to travel to california for 10-day training program (cost covered by study) * able and willing to travel to portland, or for 6 study visits over the 12 month study period (cost covered by study) exclusion criteria: * no clinically significant ms exacerbation within 30 days of screening visit * no systemically administered corticosteroids within 30 days of study entry * patient not pregnant or breastfeeding * not taking fish oil/flax seed for at least 2 months prior to first visit * no other significant health programs (e.g. active coronary heart disease, liver disease, pulmonary disease) that might increase risk of patient experiencing adverse events

Keywords: multiple sclerosis diet
irbesartan in the treatment of hypertensive patients with metabolic syndrome

Conditions: Metabolic Syndrome; Hypertension

Summary: the purpose of this clinical research study is to learn if irbesartan is superior to hydrochlorothiazide relative to effects on insulin sensitivity and glucose metabolism in hypertensive patients with metabolic syndrome.


Eligibility criteria:
inclusion criteria: * subjects must be willing and able to provide written informed consent. subjects must read, sign, and receive a copy of the informed consent prior to any study procedures, including withdrawal of any antihypertensive medication. * males and females \>= 18 years of age. * uncontrolled hypertension defined as an average systolic blood pressure \>= 140 mmhg and/or an average diastolic blood pressure \>= 90 mmhg. this applies to both people not taking any blood pressure medications and people taking just one blood pressure medication. * presenting at least 2 of the following: * obesity; * high triglycerides; * low hdl cholesterol; * elevated fasting glucose. exclusion criteria: * women of child bearing potential who are not using adequate birth control. * women who are pregnant or breastfeeding * diabetics * systolic blood pressure \>= 180 mmhg. * diastolic blood pressure \>= 110 mmhg. * stroke within past 12 months. * myocardial infarction and heart revascularization procedure or acute angina within past 6 months. * moderate to severe heart failure. * significant kidney or liver disease. * cancer in past 5 years. * drug or alcohol abuse. * gout * lupus

Keywords: metabolic syndrome
use of respiratory therapists (rts) to improve outcomes and quality of life in patients with copd

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: evaluate subjects in an prospective randomized controlled trial in which subjects will be administered scientifically validated questionnaires to determine the effect of the education and case management by respiratory therapists (rts) on improvements in: health outcomes and quality of life as primary endpoints utilize: chronic respiratory disease questionnaire (crq) the secondary endpoints will be: rate of exacerbation's, health care utilization (emergency room encounters, hospital admissions)

evaluate subjects in an prospective randomized controlled trial in which subjects will be screened and administered scientifically validated questionnaires at study entry and during the observation period at specified intervals to determine the effect of the education and case management by respiratory therapists (rts) on improvements in health outcomes and quality of life as primary endpoints, utilizing the chronic respiratory disease questionnaire (crq). the secondary endpoints will be rate of exacerbation's and health care utilization (emergency room encounters, hospital admissions).

Eligibility criteria:
inclusion criteria: * diagnosis of copd * cognitive ability to retain education and training * resides in a stable residence or home, apartment * managed by primary care physician (family practice) exclusion criteria: * lacks cognitive ability to retain education and training * not managed by primary care physician (family practice) * no stable residence or is homeless

Keywords: copd respiratory therapist case management education
brimonidine in rosacea

Conditions: Rosacea

Summary: rosacea is a chronic and relapsing inflammatory cutaneous disorder with highly variable prevalence worldwide.

in our study, we will compare the safety, efficacy, and adverse effects of low-dose oral doxycycline alone versus combined with pulsed dye laser or topical brimonidine in treating erythematotelangiectatic rosacea in an attempt to build a treatment strategy in a disease with complex pathogenesis.

Eligibility criteria:
inclusion criteria: * patient with current erythematotelangiectatic rosacea exclusion criteria: - pregnant females. 2-patients on systemic steroids. 3-patients complaining of other dermatological disorders mainly photosensitive cutaneous disorder. 4- patients receiving any systemic treatment including retinoids for the previous 1 month or any topical treatment for the previous 2 weeks or any laser sessions for the previous 3months for erythematotelangiectatic rosacea at least.
bioavailability of zinc and iron from a whey-based protein supplement consumed with a habitual plant-based diet

Conditions: Nutritional Deficiency

Summary: bioavailability of iron and zinc from habitual plant-based diets consumed by young children in mexico is low due to the high phytate content. whey protein has been found to increase zinc absorption, thus, providing a whey based supplement with micronutrients may be an effective strategy to increase iron and zinc bioavailability from plant-based foods and alleviate iron and zinc deficiencies. the investigators compared absorption of zinc and iron in children receiving diets with and without whey protein supplements (wps).

study 1: zinc absorption studies the zinc study employed a 2-day cross-over design, labeling the wps diet with a different zinc stable isotope (67zn) than the control diet (70zn). all meals during the 2-day period were labeled with tracer. the dual isotope ratio technique was used with a 3rd zn stable isotope (68zn) given intravenously and urine enrichment of all isotopes measured on study days 6-9 to measure fractional absorption of zn (faz). the amount of zn absorbed for the day was determined by multiplying the zn intake for the day (determined from lab analyses of duplicate test meals) by the faz. children (n=16) were randomized as to the order in which they consume the test and control meals on study day 1 and 2. study 2: iron absorption studies the iron study was a cross sectional study with one group receiving control meals and the second group receiving the same control meal plus wps. iron absorption was measured using the erythrocyte iron incorporation technique with labeling of all meals over 2 days (58fe). this was preceded by a reference dose of fe57 and ascorbate on the previous day. children (n=32) were randomized to receive the control diet or intervention diet (control diet + wps).

Eligibility criteria:
inclusion criteria: * 2-3 years of age * live in poor, rural communities * healthy * parents had provided informed consent exclusion criteria: * an acute or chronic illness which affects gut function, or * they are breast feeding.

Keywords: zinc absorption iron absorption whey protein mexico stable isotopes
study of lopinavir/ritonavir tablets versus soft gel capsules and once daily versus twice daily administration, when coadministered with nucleoside reverse transcriptase inhibitors in antiretroviral naive human immunodeficiency virus type 1 infected subjects

Conditions: Human Immunodeficiency Virus Infections

Summary: the purpose of this study was to compare the safety and tolerability of the to-be-marketed lopinavir/ritonavir (lpv/r) tablet formulation with the marketed soft gel capsule (sgc) formulation and to compare the safety, tolerability, and antiviral activity of once daily (qd) and twice daily (bid) dosing of the lpv/r tablet formulation in combination with select nucleoside reverse transcriptase inhibitors (nrtis) in patients who have not previously received antiretroviral treatment.


Eligibility criteria:
inclusion criteria * subjects were human immunodeficiency virus type 1 (hiv-1) positive, antiretroviral naïve adults at least 18 years of age with \< 7 days of prior antiretroviral therapy. * subjects had plasma hiv-1 ribonucleic acid (rna) levels \>= 1,000 copies/ml at screening and were not acutely ill. * female subjects were nonpregnant and nonlactating. exclusion criteria * subjects were excluded if screening laboratory analyses showed any of the following abnormal laboratory results: * presence of hepatitis b surface antigen (hbsag) * hemoglobin \<= 8.0 g/dl * absolute neutrophil count \<= 750 cells/microliter * platelet count \<= 50,000 per ml * alanine aminotransferase (alt) or aspartate aminotransferase (ast) \>= 3.0 x upper limit of normal (uln) * calculated creatinine clearance \< 50 ml/min

Keywords: human immunodeficiency virus infections
the stress management training provided to obese women

Conditions: Obese Women; Stress; Training

Summary: introduction: obesity, which is an important public healthcare issue, can affect women's physical, mental, social health, stress level, and coping negatively. aim: the present study was conducted to determine the effects of stress management training provided to obese women on eating attitudes, stress, and coping with stress.

methods: the sampling of the randomized controlled experimental study based on the pre-test and post-test model consisted of 70 women (experimental = 35; control = 35) with a body mass index ≥30, who applied to a community healthcare center obesity unit in primary care in turkey. the data were collected by using personal information form, perceived stress scale, stress coping styles scale, dutch eating behavior questionnaire, and height-weight measurements.

Eligibility criteria:
inclusion criteria: * women who lived in the city center, * body mass index ≥30, * having no perception and communication problems and being able to answer questions, * women who volunteered to participate in the study exclusion criteria: * being a man * non-obese women and those with a body mass index below 30 * those with communication problems * those who do not live in the city center

Keywords: women obesity stress stress management training eating attitude
non-invasive hemoglobin monitoring in cesarean section

Conditions: Placenta Previa

Summary: non-invasive hemoglobin monitoring will be performed in patients who underwent cesarean section with placenta previa and this will be compared with actual laboratory findings. the investigators will investigate whether noninvasive hemoglobin monitoring can adequately reflect the massive bleeding that occurs within a short period of time and find out if it matches the actual laboratory findings.


Eligibility criteria:
inclusion criteria: * pregnant woman * elective cesarean section * placenta previa exclusion criteria: * decline of consent * peripheral vascular disease * cyanosis due to congenital heart disease * refusal of transfusion * mental retardation
learning through play (ltp) plus interpersonal psychotherapy (ipt)

Conditions: Maternal Depression

Summary: to evaluate the effectiveness of a telephone based ltp plus intervention for maternal depression.

despite the high prevalence of maternal depression in pakistan, research on psychosocial interventions is limited. we will test the effectiveness of a telephone based intervention program called learning through play plus interpersonal psychotherapy (ltp plus) that can be used by non-specialists, including trained graduates, mothers and lay health workers with minimal training. this telephone communication will be supplemented by the provision of ltp plus pictorial calendars to the depressed mothers. purpose of this rct is to determine if telephone delivered intervention of the ltp plus programme reduces symptoms of maternal depression and improves infant development compared to treatment as usual. a sample of 354 (177 in each group) will be required. the study will be conducted in big cities of pakistan including karachi, lahore, hyderabad, nawabshah, quetta and peshawar.participants will be screened using patient health questionnaire (phq-9) and eligibility checklist. those scoring 10 and above on phq-9 will be invited to participate in the study. assessments will be done at baseline and after completion of intervention (3rd month and 6th month after randomization). all follow ups will be done by independent research assistants (ras), blind to the treatment allocations.

Eligibility criteria:
inclusion criteria: participants will be included in the study if they are: 18 to 44 years old mothers with children aged between 0-30 months having a diagnosis of major depressive disorder using the structure clinical interview for dsm-v, ability to complete a baseline assessment, participating mother having telephone/mobile phone access for at least one hour per week. exclusion criteria: participants will be excluded from the study if they have: any medical illness that will prevent them from participation in the clinical trial, current or past diagnosis of bipolar depression, currently using antidepressants or receiving any kind of psychotherapy, active suicidal ideation, any other severe physical or mental disorder, no access to telephone/mobile.
eus vs. mdct in pancreatic malignancy

Conditions: Resectable Pancreatic Cancer

Summary: accurate staging of patients with pancreatic cancer is critical to avoid the expense, morbidity, and mortality related to unnecessary surgery. while several tests are available for assessing such patients, consensus has not been achieved on the optimal approach. as a matter of fact, pancreatic cancer staging is discussed controversially due to conflicting evidence and certainly eus has lost grounds due to improvements in ct technology. thus, the role of eus and eus-guided fna varies among treatment centers. the present study is designed to better define the role of eus in predicting resectability, as compared to high resolution cross-sectional imaging.

registry procedures: * high-resolution pancreatic protocol computed tomography (ct) scan examination: performed on at least 16-section multi-detector row (md) ct and reviewed using multi-planar reconstructions, with images obtained following the oral administration of water and pancreatic protocol intravenous iopamidol, with images acquired in the pancreatic and portal venous phases of contrast enhancement, reconstructed as thin slice (at 1 mm - pancreatic phase or 2 mm - portal venous phase increments). * eus examination: performed within 2 weeks of the mdct, aiming visualization of the pancreas, main surrounding vascular structures, celiac and mediastinal lymph nodes, liver and left adrenal gland, with eus-fna performed at the discretion of the investigator/examiner to confirm/exclude metastases and for the confirmation of malignancy in the primary tumor. patients confirmed by eus as having distant metastases are to be deferred from the planned surgical intervention. * surgical intervention: aiming to provide curative intent (r0) resection. * histopathological postoperative staging: with evaluation of loco-regional invasiveness and degree of complete surgical resection (r0/r1). * follow-up of patients: with phone-calls on an every 6 month basis, for up to 2 years, retaining the following data: survival (or not), date of decease and its direct cause (if applicable), the presence of tumor recurrence (or not).

Eligibility criteria:
inclusion criteria: * adult (≥ 18 years of age) patients; * the presence of a confirmed pancreatic mass (suspected neoplastic) deemed resectable or borderline resectable on multislice (at least 16 simultaneously acquired slices) pancreatic protocol computed tomography (ct); * patients fit and willing to undergo surgery with a curative (r0) intent; * sign of the informed consent. exclusion criteria: * the presence of significant co-morbidities that contraindicate pancreatic resection; * previous neo-adjuvant oncologic therapy; * distant metastases; * lack of discernment; * refusal to sign the informed consent..

Keywords: pancreatic cancer resectability endosonography (eus) multidetection computer tomography (mdct) staging
self-acupressure on pain, fatigue and sleep quality in systemic lupus erythematosus

Conditions: Sleep Disorder

Summary: the aim of this study is to examine the effect of self-acupressure application on pain, fatigue and sleep quality in sle patients.

acupressure is a therapy method performed with an instrument or hand, fingertip, palm, elbow, knee, thumb relaxation and wrist bands on various points representing the waist organs in our body in order to ensure the continuation and balance of the energy in our body.

Eligibility criteria:
inclusion criteria: * being over the age of 18, * not using acupressure and similar integrative treatment methods, * not having a verbal communication disability (hearing and speaking), * not having a diagnosed psychiatric disorder, * not having a cognitive problem, * getting a score between 1-10 on the piper fatigue scale, * getting a score between 1-10 on the vas pain scale * agree to participate in the research. * not being in the active period of sle (exacerbation in the last 3 months or not using steroids for 3 months) * not using other complementary and integrated health practices in the treatment process exclusion criteria: -

Keywords: fatigue pain sleep quality systematic lupus erythemasus
the hemodynamics effect of glibenclamide on levcromakalim assessed by high resolution magnetic resonance angiography (mra) technique in a randomized double-blind cross-over placebo-controlled study with healthy volunteers

Conditions: Hemodynamics of Cranial Arteries; Headache; Cerebral Blood Flow

Summary: to investigate the effect of levcromakalim/placebo infusion on cranial arteries after glibenclamide administration.

15 healthy participants will randomly be allocated to receive levcromakalim or placebo on to different days before and after oral glibenclamide administration. the aim of the study is to investigate the effect of levcromakalim/placebo infusion on cranial arteries before and after glibenclamide administration. repeated magnetic resonance angiography (mra) measurements covering the middle meningeal artery (mma), superficial temporal artery (sta) and middle cerebral artery (mca) before and after glibenclamide administration and levcromakalim/placebo infusion.

Eligibility criteria:
inclusion criteria: * healthy volunteers of both sexes. * 18-60 years. * 50-100 kg. * women of childbearing potential must use adequate contraception exclusion criteria: * a history of serious somatic disease * migraine or any other type of headache (except episodic tension-type headache less than once a month) * daily intake of any medication except contraceptives * contraindications for mri scan.
a study of a mastoid device in subjects with ménière's disease

Conditions: Meniere Disease

Summary: the purpose of this study is to investigate the efficacy of a mastoid treatment device in patients with active ménière's disease that is not controlled by traditional medical management

this is a single center, randomized, placebo-controlled trial of mastoid oscillation for treatment of ménière's disease. eligible subjects will be randomized using a 1:1 allocation to either mastoid oscillation or placebo (oscillator device that provides the same sound but no vibration of the mastoid) received for 30 minutes at four weekly study visits, with efficacy determination via change in frequency and severity of ménière's symptoms following the final study visit.

Eligibility criteria:
inclusion criteria: 1. adults aged 18 and older 2. clinical diagnosis of ménière's disease, with classical symptoms: i. episodic spinning vertigo ii. fluctuating unilateral low frequency sensorineural hearing loss iii. tinnitus iv. aural fullness c. failure of traditional medical management of ménière's disease symptoms d. english language skills sufficient to provide informed consent to the study exclusion criteria: 1. atypical medical history of ménière's symptoms and questionable ménière's diagnosis 2. bilateral ménière's disease