Kornimate/medical-research-clean huggingface dataset:
mscs therapy for cerebral palsy

Conditions: Stem Cell Transplant Complications

Summary: cerebral palsy (cp) is the most common physical disability in childhood. cp comprises a heterogeneous group of disorders that are the result of a non-progressive disruption or injury that occurred during fetal brain development or within the first two years of life.

this disruption can result in spasticity, dystonia, muscle contractures, weakness and difficulty in coordination that ultimately affects the ability to control movements. resultant activity limitations may affect gross motor movements, fine motor movements, speech and communication, as well as eating and drinking.

Eligibility criteria:
inclusion criteria: * • must be more than 2 year of age and less than 12 years of age at the time of screening for inclusion in the study. * clinical evidence of a non-progressive motor disability due to brain dysfunction. exclusion criteria: * • intractable seizures * traumatic brain injury * genetic disorder * current infection * renal insufficiency * hepatic disease * hiv+ (as demonstrated by positive blood test) * immunosuppression
a study of efficacy, safety, and tolerability of kan-101 in people with celiac disease

Conditions: Celiac Disease; Coeliac Disease

Summary: the study goal is to evaluate the efficacy, safety, and tolerability of kan-101 in participants with celiac disease (ced)

study kan-101-03 is a multi-center, double-blind, placebo-controlled phase 2a study to examine whether kan-101 confers protection from gluten exposure induced histological changes in the duodenum and to further evaluate the safety/tolerability of kan-101 in adult participants (≥18 years) with ced on a gluten free diet. approximately 52 participants who meet study inclusion/exclusion criteria will be randomized 1:1 to receive kan-101 or placebo.

Eligibility criteria:
inclusion criteria: * previous diagnosis of celiac disease based on histology and positive celiac serology * hla-dq2.5 genotype * gluten-free diet for at least 12 months * negative or weak positive for transglutaminase iga and negative or weak positive for dgp-iga/igg during screening * screening intestinal biopsy demonstrating vh:cd ratio of 2.3 or higher exclusion criteria: * refractory celiac disease * hla-dq8 genotype * selective iga deficiency * diagnosis of type-i diabetes * other active gastrointestinal diseases * history of dermatitis herpetiformis

Keywords: celiac disease hla-dq2.5 gluten free diet
denosumab: a potential treatment option for aneurysmal bone cysts

Conditions: Bone Cyst Aneurysmal; Pathological Fracture; Recurrent Disease; Refractory Tumor

Summary: the efficacy of traditional therapeutic approaches for aneurysmal bone cysts (abc), such as surgery, embolization, sclerotherapy and radiotherapy, are often compromised for lesions in axial skeletons and adolescents complicated with pathological fracture. therefore, denosumab, a new drug that has been successfully used in giant cell tumor of bone but has seldom used in abc, was used to treat abc in this trial.

patients with primary abc treated with perioperative denosumab in the musculoskeletal tumor center of peking university people's hospital between january 2014 and december 2016 will be reported in this trial.approved by the ethics committee of peking university people's hospital and with the full informed consent from the patients or their families, all patients received surgery and treatment with denosumab perioperatively. denosumab 120 mg was given subcutaneously (abdomen wall or upper arms) every 4 weeks (q4w), with a loading dose on both day 8 and day 15 of the first cycle. meanwhile, all patients were suggested to take 800mg oral calcium supplement every day and avoid any dental or oral surgery (tooth extraction, tooth filling, etc.). patients were followed once a month since the date of surgery. on follow-up visits, patient-reported adverse reactions, x-ray image of jawbone, serum calcium, alkaline phosphatase, renal and hepatic function, hemoglobin, white blood cell, and platelet count were collected, and histological examinations, radiological examinations (such as x-ray, computed tomography (ct), magnetic resonance image (mri) and positron emission tomography-computed tomography (pet-ct) and postoperative functional status evaluations by msts（musculoskeletal tumor society） score were conducted.

Eligibility criteria:
inclusion criteria: 1. pathologically diagnosed with primary aneurysmal bone cyst 2. lesions in axial skeletons (i.e. spine, pelvis) which are difficult to reach a satisfactory surgical margin, and surgery can lead to very high incidence of complications. 3. pathological fracture 4. recurrence cases exclusion criteria: 1. metastases or multi-focal lesions 2. malignancy

Keywords: aneurysmal bone cyst, denosumab, surgical treatment, complication
effect of the consumption of alcohol-free beers with different carbohydrates composition on postprandial metabolic response

Conditions: Healthy Diet; Postprandial Hyperglycemia

Summary: the overall objective of this study is to explore the glycemic index and glycemic load induced by an alcohol-free beer with modified composition (including almost full fermentation of carbohydrates and the addition of isomaltulose and a resistant maltodextrin), as well as its postprandial metabolic response, compared to the effect induced by: a) an alcohol-free beer with a usual composition; b) an alcohol-free beer with modified composition (including almost full fermentation of carbohydrates and the addition of a resistant maltodextrin). this study includes two cross-over sub-studies recruiting healthy participants. in the first one, 10 healthy volunteers receive 25 g of carbohydrates coming from: regular alcohol-free beer (rb), alcohol-free beer with almost completely eliminated maltose and enriched with isomaltulose (2.5 g/100 ml) and a resistant maltodextrin (0.8 g/100 ml) (imb), alcohol-free beer with the same maltose removal enriched with resistant maltodextrin (2.0 g/100 ml) (mb) and glucose solution. in the second study, 20 healthy volunteers are provided with 50 g of carbohydrates from white bread and water and the same meal plus 14.3 g of carbohydrates coming from: rb, imb, mb and extra white bread. blood is sampled at baseline and for 2 h, every 15 min, after ingestion.


Eligibility criteria:
inclusion criteria: * bmi between 18.5 and 27.5 kg/m2. exclusion criteria: * presence of cardiometabolic pathology such as dyslipemia (total cholesterol \> 200 mg/dl and/or triglycerides \> 150 mg/dl, and/or taking lipid-lowering drugs), prediabetes or type 1 or 2 diabetes mellitus (glucose ≥ 100 mg/dl and/or glycosylated hemoglobin ≥ 5.7% and/or taking hypoglycemic drugs) or high blood pressure without drug treatment. * presence of other chronic pathologies that could interfere with the results of the study such as cardiovascular disease, kidney disease, thyroid disease or liver disease. * presence of intestinal malabsorption syndromes and/or presence of chron disease or ulcerative colitis. * use of drugs that may interfere with lipid and/or glycidic metabolism. * presence of some analytical alteration that could interfere with the results of the study. * increased or decreased body weight of ≥ 5 kg in the last 6 months. * gluten intolerance. * regular intake of functional foods such as phytosterols or red rice yeast, which have a significant effect on lipid or glycidic metabolism, in the last 6 weeks. * intake of vitamin supplements. * hormone replacement therapy.

Keywords: carbohydrates alcohol-free beer maltodextrin isomaltulose
study assessing the contribution of telemedicine monitoring in addition to standard follow-up of an obesity program

Conditions: Obesity

Summary: stroberry study is a prospective, monocentric, randomized, open-label study assessing the contribution of telemedicine, in addition to standard follow-up, strengthening an obesity program in berry (france). the principal objective is to study the effectiveness of a follow-up reinforced with telemedicine in addition to the standard multidisciplinary annual follow-up on the rate of patients lost to follow-up after initial or second line management in a multidisciplinary bariatric medical program

obesity became a major public health issue in france. in 2019, obesity represented 5% of annual costs in health and was responsible of a 2.7% lost in france's gross domestic product. in the scop of french health ministry's recommendations for obese patients'care and the territorial healthcare program; saint-françois' hospital set up 3 healthcare programs: "medical obesity"," interventional" and "post surgery". a very few number of studies aim to asse the efficacity of a long-term telemedicine follow-up after a bariatric medical care program. stroberry study is a prospective, monocentric, randomized, open-label study assessing the contribution of a long term, telemedical, personalized, educative quarterly, follow-up (4 years follow up), in addition to standard follow-up, strengthening an obesity program in berry (france). the principal objective is to study the effectiveness of a follow-up reinforced with telemedicine in addition to the standard multidisciplinary annual follow-up on the rate of patients lost to follow-up after initial or second line management in a multidisciplinary bariatric medical program

Eligibility criteria:
inclusion criteria: * woman or male aged from 18 to 60 years old included * patient in obesity (bmi\> or = 30) * patient who has completed a multidisciplinary medical program for obesity management, as a first- or second-line intention (after initial obesity management) at the investigating center * affiliation to a social security scheme * patient informed of the study and who had signed the informed consent form non inclusion criteria: * management of obesity within the framework of an exclusively interventional program, without redirection to a medical program * managing obesity as part of a post-operative program * pregnant or breastfeeding women * patients deprived of liberty * patients under legal protection

Keywords: obesity public health telemedicine
efficacy of a brief intervention to improve sexual and gender minorities' mental health: randomized controlled trial.

Conditions: Depression; Anxiety; Psychological Distress; Social Phobia; Post Traumatic Stress Disorder; Suicidal Ideation; Sex, Unsafe; Discrimination, Social; Behavior, Risk; Self Esteem

Summary: experiences of violence, from micro to physical aggressions, have a deleterious impact on mental health. according to the minority stress theory, unfavorable social conditions (such as anticipated and experienced discrimination and internalized homophobia), mediated by resilience strategies, can lead to mental health or illness. sexual and gender minorities (sgm) face stigma and discrimination aggravating multiple aspects of their lives: from school drop-out to halting health care access. sgm reveal avoiding medical assistance for fear of discrimination while health professionals disclose feeling unprepared to handle sgm health needs. there are two main challenges: 1) developing specific psychological interventions to reduce the impact of stigma and discrimination on sgm' mental health; and 2) training public health professionals to properly address sgm needs. therefore, the present trial aims to assess the efficacy of a brief, self-guided, on-line, asynchronous and unsupervised psychological intervention in improving sgm' mental health.


Eligibility criteria:
inclusion criteria: * self-identity as sexual and gender minority. * being older than 16 years old. * have a stable on-line connection for, at least, 20 minutes in a place where won't be disturbed. * reports, in the baseline survey, previous experiences of discrimination, having depression or anxiety symptoms. * currently living in rio grande do sul. exclusion criteria: * disagrees with the consent form.
treatment adherence and outcomes in three modalities of continuous positive airway pressure treatment for obstructive sleep apnea

Conditions: Obstructive Sleep Apnea

Summary: the purpose of this study is to compare the treatment adherence and effects in three modalities of continuous positive airway pressure treatment for obstructive sleep apnea.

obstructive sleep apnea (osa) is a common disorder that is associated with substantial morbidity, including excessive daytime sleepiness, hypertension, and cardiovascular disease. although continuous pressure airway pressure (cpap) is effective treatment of objective and subjective complaints, adherence to cpap therapy is suboptimal. recently, pressure-relief cpap (c-flex,a-flex; respironics; murrysville, pa) is available. the present study is single-blind,prospective, randomised, crossover study to compare the adherence and effects of therapy with c-flex, a-flex, and autoadjusting cpap after 3 months of cpap treatment. additionally, after 3 months of cpap treatment, the patients who treated with c-flex and a-flex will crossovered, we will acess to change of adherence and effects of cpap treatment.

Eligibility criteria:
inclusion criteria: * subjects on admission for sleep study under the respiratory care and sleep control medicine, kyoto university hospital. * subjects diagnosed with osa (apnea hypopnea index \>=5/hour) by overnight polysomnography. exclusion criteria: * subjects diagnosed with csa by overnight polysomnography. * subjects ever used cpap for osa.

Keywords: adherence continuous positive airway pressure
indolent non follicular lymphomas prognostic project

Conditions: Indolent B-Cell Lymphomas

Summary: prospective collection of data of possible prognostic relevance in patients with indolent non - follicular b-cell lymphomas.

the present study is designed as a prospective collection of information potentially useful to predict the prognosis of newly diagnosed patients with non-follicular low grade b-cell lymphoma. the study is aimed to verify whether a prognostic collection of data would allow the development of a more accurate prognostic assessment for non-follicular low grade b-cell lymphomas.

Eligibility criteria:
inclusion criteria: 1. patients with histologically confirmed diagnosis of non-follicular low grade b-cell lymphoma * splenic mzl (bone marrow histology and/or spleen tissue) * extranodal mzl of malt (tissue biopsy) * nodal mzl (lymph node biopsy) * lymphocytic lymphoma (lymph node biopsy) * lymphoplasmacytic lymphoma (bone marrow histology or lymph node biopsy) * cd5-negative low grade b-cell lymphoma (bone marrow histology) 2. age over 18 3. written informed consent exclusion criteria: 1. none

Keywords: indolent b-cell lymphomas prospective collection
a cross-specialty collaboration platform for mucopolysaccharidosis confirmative diagnosis

Conditions: Mucopolysaccharidoses

Summary: in this study the investigators is aimed to establish the mps screening algorithm for high risk patients who had medical history of previous surgical repair or presence of inguinal and/or umbilical hernia with combination of any ent related surgery or examination in taiwan.

mucopolysaccharidoses (mps) are a group of inherited lysosomal storage disorders. in individuals with mps disorders, have deficiency or malfunction of specific lysosomal enzymes leads to an abnormal accumulation of certain complex carbohydrates (mucopolysaccharides or glycosaminoglycans) in the arteries, skeleton, eyes, joints, ears, skin, and/or teeth. these accumulations may also be found in the respiratory system, liver, spleen, central nervous system, blood, and bone marrow. this accumulation eventually causes progressive damage to cells, tissues, and various organ systems of the body. due to such an extreme variability in clinical presentation as well as wide range of disease spectrum, but insufficient mps disease awareness in taiwan, these resulted in a delay diagnosis or even miss diagnosis with other clinical symptom thus patient often received inappropriate treatment. in order to address the current issue of delay diagnosis among mps patient, it is critical to develop a mps screening algorithm for high risk patients in taiwan.

Eligibility criteria:
inclusion criteria: * the subject is 0-20 years of age. * the subject had medical history of previous surgical hernia repair or presence of inguinal and/or umbilical hernia. * the subject had or is scheduled for ent surgery for any of the following, alone or in combination with adenoidectomy, tonsillectomy, ear tube insertion/tympanostomy, tracheotomy and bronchoscopy * the subject who is willing and able to provide written, signed informed consent, or by a legally authorized representative after the nature of the study has been explained and prior to any research-related procedures. exclusion criteria: -the subject has a current confirmed diagnosis of any mps disorder.
administration of subanesthetic dose of ketamine and electroconvulsive treatment for treatment resistant depression

Conditions: Treatment Resistant Depression; Major Depressive Disorder; Severe Depression

Summary: in this proof of concept study, the investigators plan to administer iv ketamine interleaved with ect days. patients with treatment resistant depression who are deemed to be eligible for ect treatment will randomly be assigned to either ketamine or active placebo.

the study will compare the effects of standard ketamine dosing with an active placebo arm. hypothesis 1: the investigators hypothesize that interleaved electroconvulsive treatment and active ketamine treatment will lead to a meaningful clinical improvement compared to electroconvulsive treatment and placebo treatment arm. hypothesis 2: the investigators hypothesize that interleaved electroconvulsive treatment and active ketamine treatment will attenuate cognitive side effects. methods and design: patients with treatment resistant depression who are deemed to be eligible for electroconvulsive treatment will randomly be assigned to either ketamine or active placebo electroconvulsive treatments: all patients (independent of their depression scores) will receive the same electroconvulsive treatment parameters: bi-frontal brief pulse (0.5 miliseconds) electroconvulsive treatment administered by using thymatron electroconvulsive treatment machine. study blinding: neither the patients, nor the treating psychiatrist or the nurse will be aware of the patient's assigned arm. the success of blinding will be tested after each ketamine treatment with a questionnaire given to the subject, raters, and treating physician.

Eligibility criteria:
inclusion criteria: 1. males/females at least 18 years of age but no older than 65 years of age 2. meet diagnostic and statistical manual of mental disorders-4th edition (dsm-iv) criteria for major depression or bipolar disorder, depressed phase, as determined by a clinician's diagnostic evaluation and confirmed by interview using the mini international neuropsychiatric interview (mini plus 5.0.0) 3. a current depressive episode that has lasted a minimum of 4 weeks. 4. have \> 3 trials of antidepressants/augmentation strategies. 5. have a support system capable of transporting the patient post-treatment. exclusion criteria: 1. meeting diagnostic and statistical manual of mental disorders criteria for schizophrenia, schizophreniform disorder, schizoaffective disorder, mental retardation, pervasive developmental disorder. 2. meeting diagnostic and statistical manual of mental disorders criteria for other substance/alcohol dependence within the past 6 months or abuse in the past 3 months. 3. patients who meet exclusion criteria for ketamine and/or midazolam infusion.

Keywords: ketamine electroconvulsive therapy major depressive disorder treatment resistant depression electroconvulsive treatment severe depression
social web mining for suicide prevention

Conditions: Suicidal Behaviors

Summary: according to a recent and alarming who (world health organisation) report (september 4, 2014), one person dies of suicide every 40 seconds in the world. suicide is the third-leading cause of death for 15- to 24-year-olds, according to the centers for disease control and prevention , after accidents and homicide. this major public health issue need prevention strategies especially directed to at-risk populations. since 2013, more than 2 billion users are enrolled in social networks such as twitter or facebook. young adults (ages 18 to 29) are the most likely to use social media - fully 90% do. consequently, in this project, we focus on suicide prevention in social media network.. the aim of this project is the validation of the algorithm. this algorithm build a decision support system that monitor young people at-risk based on large volume of heterogeneous data collected through social media to improve suicide prevention.

this study is composed of two steps : 1. 9 subjects were recruited. after patients agreement, computer scientists were accessing to patient social network profile. computer scientists were not able to visualize the content of publications, just run the algorithm that will analyse the content of messages (text, frequency, emoticons...) the algorithm defines the 3 most at-risk periods of suicide behaviors, on the next month. this result were compared to periods found by psychiatric interview. the psychiatrist then confirmed or not to lirm whether periods found by the algorithm conrrespond to those defined by the psychitrist. no data of the social network were collected. 2. the 2nd step aim to improve the algorithm by collecting sociodemographic and clincal data related to patients included.

Eligibility criteria:
inclusion criteria: * major patient * minor patient with parents approval * patient hospitalized due to suicide attempt or suicide ideations * frequent active user of social netword (facebook, instagram, youtube, twitter) exclusion criteria: - patient's refusal to participate

Keywords: suicide prevention social network
non-invasive continuous cardiac output monitoring in preterm infants study

Conditions: Cardiac Output, Low; Cardiac Output, High; Blood Pressure

Summary: this is an observational study in newborn term and preterm infants. the study will validate if non-invasive continuous cardiac output monitoring is feasible in newborn infants, if normative values can be constructed and what is the effect of fluid boluses and inotropes on cardiac output and peripheral vascular resistance.

this is a 3-year prospective observational study. principal research question: is non-invasive continuous cardiac output (co) measurement a validated tool of comprehensive cardiovascular assessment in neonatal intensive care (nicu)? secondary research questions: 1. can robust normal ranges of co be constructed for neonates undergoing cardiovascular measurement? 2. how do neonatal interventions (fluid boluses, ventilation and inotropes) affect co? 3. does the non-invasive continuous cardiac output monitoring in children with foetal growth restriction (fgr) differ from normative co data as above (1)? a prospective study of stable newborn babies in the postnatal ward and sick term and preterm infants in the nicu in 36 months.

Eligibility criteria:
inclusion criteria: * healthy term infants in postnatal ward (within the first 72 hours of age) * term and preterm infants (including those with fgr) admitted to the neonatal unit * written informed parental consent (prospective for postnatal ward and retrospective for babies admitted to the neonatal units) exclusion criteria: * antenatal or postnatal diagnosis of severe congenital anomaly * infants with no realistic chance of survival * infants who are \>12 hours of age * infants with fragile skin not permitting skin probe placement

Keywords: blood pressure