Kornimate/medical-research-clean huggingface dataset:
the bacterial composition of the stomach in reflux disease

Conditions: GORD; Oesophageal Cancer; Oesophageal Reflux; Gastric Cancer; Gastro Esophageal Reflux; Oesophageal Carcinoma; Barrett Esophagus; Esophagitis

Summary: gastric and oesophageal (og) cancer associated with poor long term outcome as overall less than 25% of patients survive for more than 5 years due to late recognition of the disease. growing evidence suggests an important role for bacteria in og cancer and gastro esophageal reflux disease (gord) development. about 1 in 10 people suffer from gord and this one of the most common conditions leading to gastric and oesophageal cancer. in gord surgical therapy is the most successful preventing cancer but around 85% of patient experience complications afterwards. acid suppressing medications are reducing the risk of oesophageal cancer but equally increasing the risk of gastric cancer. they also shorten patients' life expectancy and often fail to provide relief. analysis of stool samples of patients with gord demonstrated different gut bacterial compositions to normal and rather resembled the one found in cancer. there is a clear need to improve the outcome of og cancer. this could be achieved by identifying bacteria responsible for cancer development in gastric tissue, gastric content and saliva and potentially eliminate them hence avoid the development of cancer.


Eligibility criteria:
inclusion criteria: * patients who deemed necessary for an upper gastro intestinal endoscopy for clinical reasons and consent for additional gastric mucosal biopsies for study purposes exclusion criteria: * patients who have upper gi malignancy
electrical activity of diaphragm as a means to predict extubation success in preterm infants

Conditions: Respiratory Distress Syndrome

Summary: mechanical ventilation used to support the sick newborn infant is associated with many complications including the development of chronic lung disease. limiting prolonged invasive ventilation remains an important strategy to decrease lung injury and prevent chronic lung disease. currently, there is no objective measure available to predict readiness for removal of the endotracheal tube ("extubation") and discontinuing mechanical ventilation in this fragile population. the investigators propose to predict extubation success by evaluating the electrical activity of the diaphragm (edi), which provides important information about the "drive" to breathing coming from the brain and the function of the diaphragm, two essential factors determining extubation readiness and success.

in this observational study, very low birth weight preterm infants with rds who require mechanical ventilation in first 24 hour of life will be recruited. a size appropriate nasogastric tube with multiple array of electrodes (edi catheter) will be inserted in each eligible infant. the average edi (edi_avg) will be measured during mechanical ventilation just before extubation. all infants will be extubated to non-invasive positive pressure ventilation (nippv or cpap) delivered through nasal cannula the specific aim is to determine whether there is a relationship between edi_avg before extubation and the extubation success in a sample of preterm infants with respiratory distress syndrome (rds). we hypothesize that edi-avg of infants with successful extubation will be significantly different from the infants who fail extubation

Eligibility criteria:
inclusion criteria: preterm infants less than 35 week gestation, requiring intubation and mechanical ventilation for respiratory distress in the first 24 hours of life exclusion criteria: infants with a non-intact esophagus (e.g tracheal-esophageal fistula or atresia), a non-functional diaphragm (e.g. phrenic nerve palsy), severe intracranial hemorrhage or structural cns abnormality, severe birth asphyxia and critically sick infant needing paralysis or deep sedation.

Keywords: preterm rds mechanical ventilation extubation failure
efficacy and safety trial of the alk hdm tablet in house dust mite allergic subjects

Conditions: Asthma

Summary: the purpose of the trial is to determine if treatment of asthma patients allergic to house dust mites with the alk hdm tablet can reduce the need of inhaled corticosteroids (ics).


Eligibility criteria:
inclusion criteria: * a history of house dust mite induced asthma * use of inhaled corticosteroids (ics) * positive skin prick test to house dust mites * positive specific ige to house dust mites exclusion criteria: * fev1 lower than 70%
a study of si-6603 in patients with lumbar disc herniation

Conditions: Intervertebral Disc Disease; Lumbar Disc Disease

Summary: the purpose of this study is to evaluate the efficacy and safety of si-6603 (condoliase) in patients with lumbar disc herniation.


Eligibility criteria:
inclusion criteria: * patients with lumbar disc herniation (l4-l5 or l5-s1) as assessed by mri and clinical symptoms corresponding to position of the impaired nerve root. * patients assessed as positive in the slr test. * patients with sciatica in either leg. * patients with no improvement from conservative treatment exclusion criteria: * patients who have 2 or more lumbar disc herniations as assessed by mri. * patients in whom a rupture into the posterior longitudinal ligament is identified by mri. * patients who have received spinal injection, epidural injection, nerve block within 3 weeks prior to the time of informed consent. * patients who have undergone lumbar operation, or lumbar percutaneous nucleotomy or lumbar intradiscal therapies
safety and efficacy study of ingn 241 gene therapy in patients with in transit melanoma

Conditions: Malignant Melanoma; Neoplasm Metastasis

Summary: this is a research study to look at the ways in which a treatment called ingn241 can kill melanoma cells or help the patient's immune system kill melanoma cells.

ingn 241 is an adenoviral vector carrying the mda-7 cdna. mda-7 is a novel tumor suppressor molecule with cytokine properties, recently designated as il-24. over expression of mda-7 in melanoma cells in vitro has been shown to inhibit cellular proliferation and induce apoptosis. loss of mda-7 expression in human melanomas has been shown to correlate with invasion and metastasis. the ingn 241 gene transfer construct has been previously used in human subjects in an ongoing open label phase i study using intratumoral administration, and has been well tolerated to date. the primary objectives of the present study are to determine if ingn 241, injected into a melanoma in transit lesion, can induce apoptosis in regional uninjected lesions and initiate systemic immune activation. secondary objectives include examination of specific immunity and of clinical response and toxicity.

Eligibility criteria:
inclusion criteria: * histologically proven melanoma, must have 3 regional metastatic lesions that are in transit exclusion criteria: * central nervous system involvement by melanoma

Keywords: gene therapy melanoma adenovirus in-transit melanoma metastatic melanoma
effect of the uterotonic carbetocin on acute post cesarean-section pain

Conditions: Cesarean Delivery

Summary: carbetocin is an oxytocin agonist used for prevention of postpartum bleeding after cesarean delivery. first studies revealed in 2012 an analgesic effect of carbetocin, compared to its parent substance oxytocin. this study will enroll 78 women undergoing cesarean delivery. in a double-blind, prospective design patients will be either attributed to the oxytocin or the carbetocin study arm. the primary endpoint will be the area of hyperalgesia around the cesarean delivery scar. this will be performed with a von frey hair, resulting in a unpleasant feeling in the area of hyperalgesia.


Eligibility criteria:
inclusion criteria: * age 18-45, uneventful pregnancy, on term (\>37 0/7 weeks of gestation), scheduled elective cs including repeat cs exclusion criteria: * lack of informed consent, active labor, multiple pregnancy, polyhydramnios, severe fetal malformations
treprostinil in newborns with pulmonary hypertension; a non-interventional study to collect data on drug utilization, safety, and effectiveness

Conditions: Persistent Pulmonary Hypertension of Newborn

Summary: this observational study will seek to describe the uses and safety and efficacy outcomes of treprostinil in clinical practice in patients with persistent pulmonary hypertension (pphn).


Eligibility criteria:
inclusion criteria: 1. newborn infants who received at least one dose of iv or sc treprostinil as per clinical practice within 5 years from the moment of data collection. 2. aged up to 44 weeks after conception at treprostinil initiation. 3. pulmonary hypertension (ph) or suspicion of ph at the moment of treprostinil initiation. 4. parent(s) or legally authorized representative(s) provides non-opposition consent for the patient participation in the study. 5. newborn infants affiliated to french social security. exclusion criteria: * none.
to investigate airway oxygen concentrations during rigid bronchoscopy procedures performed with high frequency jet ventilation

Conditions: Central Airway Obstruction

Summary: thermal ablation (use of treatment modalities that generate heat) has become a widely used tool for treatment of central airway obstruction (e.g. laser, electrocautery, radiofrequency, and argon plasma coagulation). however, this method carries with it an increased risk for airway fire - a surgical fire that occurs in a patient's airway and could also include a fire in the attached breathing circuit. to decrease the risk of airway fire during mechanical ventilation with an endotracheal tube, the concentration of inspired oxygen (fio2) is set below 40% while waiting for end tidal oxygen concentration (eto2) to fall below 40% prior to starting thermal ablation. there is no published literature describing o2 concentration within the airways (aio2) during jet ventilation with rigid bronchoscopy. the co-investigators of this study have recently collected data on aio2 during rigid bronchoscopy using manual low frequency jet ventilation/high frequency jet ventilation with a period of apnea. the intent of this study is to measure the time taken for the central airway oxygen concentration to drop from 90 to 40% when the "laser mode" is activated on the monsoon jet ventilator. ventilation is continued during "laser mode."


Eligibility criteria:
inclusion criteria: * patients undergoing rigid bronchoscopy for treatment of central airway obstruction at fv ummc will be identified. * 18 years or older * need rigid bronchoscopy as pre-determined by the interventional pulmonologist exclusion criteria: * refusal to sign consent * pregnant patients * hemodynamic instability defined as continuous infusion of medication in order to support blood pressure and/or heart rate/rhythm * respiratory instability defined as spo2\&lt;90% with \&gt;90% supplemental oxygen. * ineligible for rigid bronchoscopic intubation * latex allergy * evidence of fistulous airway * active bronchopleural fistula
andro 2002: dehydroepiandrosterone (dhea) or testosterone versus placebo in men with sexual dysfunction

Conditions: Erectile Dysfunction

Summary: androgen deficiency in the aging male is poorly understood. the objective of this study will be to determine the role of testosterone and dhea in enhancing sexual interest and sexual performance.

120 men with a diagnosis of erectile dysfunction (ed) will be randomized to one of three arms in the study, dhea (50 mg), testosterone \[t\] (80 mg) or placebo. patients will be evaluated after starting blinded medication at 30 day intervals for a total of 90 days. response will be evaluated with blood parameters, physical examination including rectal examination, validated questionnaires and global assessment scales.

Eligibility criteria:
inclusion criteria: * erectile dysfunction (ed) exclusion criteria: * prior use of dhea or t

Keywords: ed dhea testosterone
cytoscopic antibiotic irrigant to reduce postoperative urinary tract infection

Conditions: Urinary Tract Infections

Summary: postoperative urinary tract infections (utis) affect 20-30% of patients undergoing elective gynecologic surgery and have a significant socioeconomic impact and cost. preoperative antibiotics, sterile operating techniques, postoperative antibiotic and non-antibiotic medical therapies have been utilized to attempt to decrease this rate with little improvement. utilization of an intraoperative antibiotic cystoscopic irrigant may decrease postoperative utis. the investigators have designed a prospective randomized controlled study to evaluate the effectiveness of an antibiotic cystoscopic fluid in preventing postoperative urinary tract infections in women undergoing elective pelvic floor surgery with cystoscopy.


Eligibility criteria:
inclusion criteria: * adult women at least 18 years of age * elective female pelvic medicine and reconstructive surgery or gynecologic minimally invasive surgeries including hysterectomy, suburethral sling, and pelvic organ prolapse repair that require cystoscopy. exclusion criteria: * surgeries that include: intradetrusor botox, vaginal mesh excision, and fistula repair * pregnancy * history of nephrolithiasis * allergy to study medications * congenital urogenital anomaly * neurogenic bladder
eye tracking and simulated postpartum hemorrhage

Conditions: Simulation of Physical Illness

Summary: eye tracking is the process of measuring an individual's eye movements in order to reflect their attentional behavior by using a device called an eye- tracker. this study uses eye-tracking methodology to observe the gaze patterns of participants to a high fidelity simulation scenario of postpartum hemorrhage acting in the role of leader to evaluate the relationship between eye-tracking patterns and leadership and team behavioral and technical skills.

this study will include 5 groups of anesthesia trainees consisting of 5 participants each. each group will practice a standardized high-fidelity scenario on postpartum hemorrhage (pph) which will be repeated for four times. all the scenarios will be video recorded. all groups will receive a technical briefing on the pph guidelines before the scenario, and after having assigned to each participant a role (leader anesthesiologist, junior anesthesiologist, obstetrician, and midwife) they will practice a standardized 15 minutes scenario with a high fidelity manikin. a debriefing with an expert debriefer will be performed after each scenario. the participant acting as the leader will practice the scenario while wearing a pair of eye-tracking glasses (tobii pro glasses 50 hz wearable wireless eye-tracker). all the eye-tracking video-recordings will be stored and analyzed by using a tobii pro lab software. specific areas of interest (aoi), to define regions of a displayed stimulus, and to extract metrics specifically for those regions will be selected. number and duration of fixations, visit counts and their duration for each area of interest and for each scenario will be examined. eye-tracking metrics will be mapped as gaze plots and heat maps. two independent observers will review the scenario video recordings and will assing a score to the leader and team behavioral and technical skills. these scores will be correlated to eye tracking metrics.

Eligibility criteria:
inclusion criteria: * anesthesia trainee exclusion criteria: * severe vision defects
reduction of myocardial infarction by preconditioning in patients with ruptured abdominal aortic aneurysm

Conditions: Abdominal Aortic Aneurysm

Summary: preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(arr from 27% to 5%). precondition where performed by 10 minutes of clamping of each iliac arteries before clamping the abdominal aorta. human studies in cardiac patients have shown promising results with precondition. instead of clamping arteries they have all performed the procedure by inflating a blood pressure cuff above arterial pressure on a arm. the investigators want to investigate if preconditioning induced by a blood pressure cuff on a arm can reduce the perioperative rate of myocardial infarction in patients open operated for ruptured abdominal aortic aneurysm.


Eligibility criteria:
inclusion criteria: * patients with ruptured abdominal aortic aneurysm offered surgery * age \> 18 years exclusion criteria: * technical inoperable

Keywords: precondition ruptured abdominal aortic aneurysm myocardial infarction
vertical transmission of hepatitis c in adult children of female baby boomers

Conditions: Hepatitis C; Hepatitis C, Chronic

Summary: the investigators aim to determine the prevalence of hepatitis c in the adult children of female baby boomers. during the years baby boomers were becoming pregnant, hepatitis c testing was either not available or was not standard of care. because of this, participants' children may be unaware of participants' risk of hepatitis c.


Eligibility criteria:
inclusion criteria: mothers: * born between 1/1/45-12/31/64 * black or white race * active or prior infection with hepatitis c * have at least one living adult child over the age of 18 children: * ≥18 years of age * born to mother with current or prior hcv infection, with likely timing of hcv acquisition prior to or during pregnancy * mother gave informed consent for child to be approached for study participation exclusion criteria: mothers: - unwilling to disclose hepatitis c status to children
the effect of flexitarian, time-restricted eating on cardiometabolic traits in normal weight, young men

Conditions: Cardiometabolic Syndrome; Glucose Metabolism Disorders; Blood Pressure; Lipid Metabolism Disorders

Summary: the goal of this factorial randomized controlled trial is to find out whether time-restricted eating and flexitarian diet (on its own and combined) can improve cardiometabolic health markers in normal weight, young men with metabolic abnormalities? participants will be assigned to four groups: control, flexitarian, time-restricted eating and time-restricted eating + flexitarian. investigators will look for men with elevated fasting blood glucose or blood lipids level or blood pressure and with normal body weight and waistline. participants from the flexitarian group will be asked to follow a diet that has been carefully designed for them by the pi and dietitian for the period of 8 weeks. participants from the control group will receive general healthy eating recommendations. we aim to investigate if the experiment had any effect on changes in metabolic, inflammation and nutritional markers, blood pressure and body weight and composition. also, the effect of diets on men's sleep, general wellbeing and satisfaction with treatment will be investigated. the proposed study can test a potentially effective nutritional intervention which is feasible to adopt and sustainable (in line with recent planetary diet recommendations). confirming its effectiveness can fill the research gap, providing new knowledge and approach to the prevention and treatment of metabolic abnormalities in young, lean men.


Eligibility criteria:
inclusion criteria: * males * age 18-40 years * normal body weight * at least one of metabolic abnormalities (elevated fasting glucose level - but not diabetes, elevated blood lipids, elevated blood pressure) exclusion criteria: * females * age \ 40 years * overweight or obesity (bmi\>25 kg/m2) * wc \> 94cm * alcohol \>14 units/week * smoking * on medication * diabetes or other chronic diseases * vegetarians or vegans * don't own or unable to use a smartphone with apple ios or android os
ocular growth factors profile in proliferative retinopathies before and after intravitreal bevacizumab

Conditions: Proliferative Diabetic Retinopathy; Age Related Macular Degeneration

Summary: aims of the trial: establishing the profile of the growth factors and other mediators of angiogenesis in different ocular fluids (aqueous humour, vitreous gel and ocular liquid in vitrectomized eyes), in the 2 most frequent proliferative retinopathies - diabetic proliferative retinopathy (pdr) and exudative age related macular degeneration (amd). following up the dynamic of this profile before and after intravitreal administration of bevacizumab (avastin) as an anti-vegf blocker. materials: the research will be conducted on the following categories of patients groups: * nondiabetic patients without amd or any other diagnosed proliferative ocular disease (controls) * patients with age related macular degeneration (amd groups) before and after intravitreal injections with avastin * diabetic patients with different types of diabetic retinopathy, before and after intravitreal avastin (diabetic groups) methods: samples from different ocular fluids will be collected from each group of patients. 10 growth factors and other 10 cytokines will be determined in the ocular fluids samples. results: the results from the biochemical measurements will be statistically interpreted in order to obtain conclusions for the clinical practice. conclusions: the conclusions of this trial will be used exclusively for research publications and communications, as well as for clinical practice.


Eligibility criteria:
inclusion criteria: * age over 20 years * nondiabetic patients requiring cataract surgery or vitrectomy for different posterior segment nonproliferative disorders - controls groups * diabetic patients asking ophthalmologic treatments for different degrees of decreasing of visual acuity - diabetic groups * diabetic patients requiring cataract surgery or vitrectomy - diabetic groups * age related macular degeneration patients asking ophthalmologic treatments for different degrees of decreasing of visual acuity - age related macular degeneration groups * age related macular degeneration patients requiring cataract surgery or vitrectomy - age related macular degeneration groups exclusion criteria: * patients under the age of 20 years * patients that did not accept and signed the informed consent of the trial * patients that received any anti-vegf therapy for any proliferative or inflammatory ocular disease * patients that received any type of intraocular injection with any pharmaceutical agent * patients with any clinical type of malignancy in their pathologic antecedents * patients with recent penetrating trauma (less than 1 year old) * patients operated for different ocular disorders requiring combination with antimetabolites (ex. 5-fu or mitomycin c with trabeculectomy) * patients with intraocular inflammations or infections or other pathologies that contraindicate open globe surgery or intraocular injections with anti-vegf blockers
a study on the treatment of recurrent clubfoot with the tendon release of musculi tibialis posterior

Conditions: Recurrent Clubfoot

Summary: the musculi tibialis posterior can adduct the foot, so releasing the tedon of the muscle can help to correct the deformity of the forefoot adduction.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of recurrent idiopathic clubfoot * the initial treatment was treated with the ponseti method * dynamic supination * the max-dorsiflexion of angle \<5° * the fore foot is adduct * the sole is cavus exclusion criteria: * symptomatic recurrent clubfoot * tarsal fusion * rigid recurrent clubfoot

Keywords: musculi tibialis posterior tendon release anterior tibial tendon transfer