Kornimate/medical-research-clean huggingface dataset:
the mechanisms of underlying accelerated repetitive transcranial magnetic stimulation for treatment-resistant depression

Conditions: Treatment-resistant Depression

Summary: in this project, the investigators evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression. the investigators focuse on participants' brain activity and blood markers (reelin, apoer2, nmdar, bdnf, exosomes and so on) to deepen the understanding of the mechanism of accelerated rtms for treatment-resistant depression.

in this project, the investigator evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression. patients were included in two groups and received an accelerated stimulation or sham treatment. the changes of neuroimaging and biomarkers at baseline, 5 days after treatment and 1 month after treatment are evaluated. the investigators focuse on participants' brain activity and blood markers (reelin, apoer2, nmdar, bdnf, exosomes and so on) to deepen the understanding of the mechanism of accelerated rtms for treatment-resistant depression.

Eligibility criteria:
inclusion criteria: 1. the current episode met the dsm-5 diagnostic criteria for major depression in patients with first-episode or relapsed unmedicated depression without psychotic symptoms. 2. 24-item hamilton depression scale (hamd-24) ≥ 20. 3. age 18-45 years, regardless of gender. 4. right-handedness. 5. han chinese. 6. signed a written informed consent, willing to participate in the study and be evaluated. exclusion criteria: 1. co-morbid other mental disorders, including: schizophrenia, mental retardation, substance dependence, etc. 2. patients with metal objects in the body or with other contraindications to mri scanning 3. patients with severe or unstable somatic diseases 4. women during pregnancy or lactation, and women of childbearing age with positive urine hcg test results during the screening period 5. other conditions that, in the opinion of the investigator, exist that make participation in this clinical trial inappropriate.

Keywords: treatment-resistant depression repeated transcranial magnetic stimulation prefrontal-hippocampal circuit reelin synaptic plasticity
the impact of a diagnosis of parkinson's on work

Conditions: Parkinson Disease

Summary: parkinson's disease leads to loss of employment on average within less than 10 years of disease onset and has been found to be associated with an increased absence from work. this combined with hospitalisation; use of secondary health services; drug usage; and caregivers needing to give up work contributed to the costs associated with the conditions. it has been estimated that early support for working age newly diagnosed would cost the government about 1.5 million euro in the uk but might lead to a potential cost saving of over half a billion over 5 years. the study will explore the impact of a parkinson diagnosis on employment. the study will be survey based and will include demographic questions: age, age at diagnosis of pd, educational level, and nationality; questions pertaining to employment type, history, and reasons for leaving if this happened; and also general health.


Eligibility criteria:
inclusion criteria: diagnosis of parkinson exclusion criteria: none

Keywords: employment work diagnosis early support
the effect of a 30-day automated text messaging intervention on hospital based acute care encounters following ileostomy

Conditions: Ileostomy; Complications; Ileostomy - Stoma; Ileostomy Malfunction; Ileostomy Underactive; Complication of Surgical Procedure

Summary: each year a large number of patients undergo ileostomy surgery, a procedure in which a portion of the small intestine is attached to a hole in the abdominal wall, allowing for digested material to pass into a disposable bag worn attached to the skin. ileostomies are performed for the treatment of a variety of diseases of the intestinal tract, such as inflammatory bowel disease, intestinal trauma, and gastrointestinal malignancy. of the patients that undergo ileostomy surgery, 36% will require urgent medical care within the first 30 days of surgery. most frequently, this is a result of dehydration due to excessive ostomy output. thus, there is potential for significant improvement of the post-operative outcomes of ileostomy patients. implementation of an automated text messaging system, epxostomy, can provide a way of monitoring patient's daily ostomy output and allow for timely intervention if output is outside normal limits, providing an effective way of improving patient outcomes while simultaneously reducing healthcare costs.

each year thousands of patients undergo ostomy surgery in the treatment of diseases such as colorectal cancer, crohn's disease, diverticulitis, and ulcerative colitis. during the 30-day post-operative period, patients that undergo ileostomy have a 36.1% rate of acute healthcare encounter compared to 16.2% of patients undergoing similar surgery but with primary anastomosis. the 30-day hospital readmission rate for ileostomy patients due to dehydration and renal failure is 17%, with the median cost per colorectal surgery readmission being $8,885. thus, there is substantial room for post-operative improvement in the care of ileostomy patients, both to reduce healthcare costs and improve patient quality of life. an automated text messaging system can provide a way to consistently monitor patients' ileostomy output, ensuring that patients are measuring their daily output as instructed and allowing for timely preemptive intervention should output be outside normal limits.

Eligibility criteria:
inclusion criteria: * patients between 18-90 years of age with phone or text receiving device access. * english speaking * patients undergoing ileostomy surgery exclusion criteria: * patients who do not have phone or text receiving device access * patients mentally unable to provide consent for the study * patients who do not speak english
pilot prospective cgm quality improvement (qi) project in pregnancy

Conditions: Diabetes Mellitus, Type I

Summary: a single-center, prospective, 'open-label,' investigator-initiated pilot study evaluating the role of continuous glucose monitor (cgm) use either alone or with remote monitoring capabilities during pregnancy associated with t1dm.

a single-center, prospective, 'open-label,' investigator-initiated pilot study evaluating the role of continuous glucose monitor (cgm) use either alone or with remote monitoring capabilities that enable subjects to share cgm data with family and friends (whom the investigators will call "followers" in this protocol) among women with t1dm associated with pregnancy.

Eligibility criteria:
inclusion criteria: * signed informed consent before any study-related activities * female aged 18 years and older * t1d duration \>1 year * pregnancy with confirmation of gestational age 13 weeks or less * willingness to routinely practice at least 3-7 blood glucose measurements per day * using mdi or csii therapy * willingness to provide an a1c level * ability and willingness to adhere to the protocol including scheduled study visits for the duration of the pregnancy * able to speak, read, and write english exclusion criteria * extensive skin changes/diseases that inhibit wearing a sensor on normal skin * known allergy to adhesives * any other condition, as determined by the investigator, which could make the subject unsuitable for the trial, impairs the subject's suitability for the trial, or impairs the validity of the informed consent
cardiac function and exercise capacity in pulmonary arterial hypertension

Conditions: Pulmonary Arterial Hypertension

Summary: pulmonary arterial hypertension is characterized by a progressive increase in pulmonary vascular resistance inducing shortness of breath and exercise intolerance. we aim to correlate cardiac function (evaluated at rest by right heart catheterism and rmn) to exercise capacity (evaluated by endurance time at 75% of maximal workout), in prevalent patients with pulmonary arterial hypertension, and their evolution at three and twelve months.


Eligibility criteria:
inclusion criteria: * adult patients * patients with pulmonary arterial hypertension (idiopathic, heritable or due to anorexigens), * prevalent cases of pulmonary artery hypertension (≥ 6 months) confirmed by right heart catheterism, * stable for at least 3 months, * written consent. exclusion criteria: * patients unable to proceed with six-minute walk test or cpet, or with contra-indication to exercise evaluation (syncope, low cardiac index, etc). * exercise induced abnormality (evaluated during the initial cpet) precluding to further evaluation.
attitude and practice for deep caries management between egyptian and indian dentists : a cross sectional study

Conditions: Deep Dental Caries

Summary: study type: observational study to assess and compare the attitudes, and practices of dentists in egypt and india regarding the removal of deep dentin caries and preferred restorative strategies. in addition to correlate between dentist's understanding of caries and its treatment and factors such as age, gender, degree of education and clinical setting.

study type:observational study to evaluate and compare the views and practices of dentists in egypt and india concerning the removal of deep dentin caries and their preferred restorative approaches. additionally, the study aims to examine the relationship between dentists' understanding of caries and its treatment, along with factors such as age, gender, level of education, and clinical environment. primary outcome-attitudes, and practices of dentists in egypt and india regarding the removal of deep dentin caries and their preferred restorative strategies. secondary outcome:the relationship between dentists' attitudes and their practices in managing deep caries treatment may be affected by factors such as age, gender, education level, and clinical experience. comparison groups: population (p1): dentists practicing in egypt - population(p2) : dentists practicing in india

Eligibility criteria:
inclusion criteria: * inclusion: licensed dentists actively practicing in egypt or india. exclusion criteria: * exclusion: dentists not currently practicing or recent graduates without practical experience

Keywords: deep caries dentine caries
antecedents of obesity: fetal measures of adiposity

Conditions: Obesity

Summary: the purpose of this research is to study whether fetal biometrics obtained by 2-d ultrasound can predict infant adiposity by air displacement plethysmography at birth.


Eligibility criteria:
inclusion criteria: * infants of mothers between the ages of 18 and 45, planning child birth at the university of utah hospital, and willing to provide parental permission for the child to participate in the study. exclusion criteria: * infants of mothers under the age of 18, over the age of 45, planning child birth at another facility other than the university of utah hospital, or who are not willing to provide permission for the child to participate in the study.
study in non-responder hepatitis c genotype 1 patients with emz702, pegylated interferon and ribavirin

Conditions: Chronic Hepatitis C; Hepatitis, Viral, Human

Summary: the purpose of this study is to assess the safety and efficacy of repeated intravenous infusions of emz702 in combination with pegylated interferon and ribavirin in patients with chronic hepatitis c genotype 1.

in this study, 28 patients with chronic hepatitis c genotype 1 who have failed previous treatment with pegylated interferon plus ribavirin will be treated. the study treatment will consist of the same type and doses of pegylated interferon and ribavirin to which the patient failed to respond plus emz702. emz702 will be administered intravenously twice a week during the first 12 weeks of treatment. thereafter and according to viral response, patients will continue to receive pegylated interferon and ribavirin only for up to 36 weeks.

Eligibility criteria:
inclusion criteria: * hepatitis c virus (hcv) genotype 1 * previous therapy with pegylated interferon and ribavirin * documented previous treatment failure exclusion criteria: * hepatic dysfunction * coinfection with hepatitis b or hiv * other unrelated liver diseases * liver cancer

Keywords: hepatitis c genotype 1 non-responders viral hepatitis
efficacy of neuro-haart in patients with hiv

Conditions: HIV

Summary: patients infected with human immunodeficiency virus (hiv) are at risk of brain related complications despite the use of highly active antiretroviral therapy (haart). such complications are termed hiv neurocognitive disorders (hand) and comprise a spectrum from asymptomatic neurocognitive impairment (ani), through mild cognitive impairment (mci) to severe hiv dementia (had). prior to haart approximately 30% of patients with advanced hiv disease had cognitive impairment; with haart the incidence of hand has decreased but its prevalence increased. the reasons for the ongoing development of cognitive impairment in haart treated patients are not clear. they might relate to virus induced brain injury prior to starting haart, the onset of a separate neurological process, toxicity related to haart, or ongoing viral infection in the brain. it is clear that the ability of different antiretroviral drugs to penetrate the brain varies but what is not established is whether these differences between drugs lead to different neurological outcomes. the investigators propose to study hiv infected patients stable on haart for 12 months; subdividing the groups according to the brain penetrance of their drug combination. patients would undergo neuropsychological assessment and mri brain scan at the start of the study and after 12 months. differences in neuropsychological tests and mri would be sought between treatment groups to establish whether haart with better cns penetration is associated with better outcome and fewer mri changes.


Eligibility criteria:
inclusion criteria: * hiv positive with nadir cluster of differentiation 4 (cd4) count \<350 /microlitre (ul) * taking haart with cns penetration effectiveness (cpe) score of either ≤7.0 or ≥7.5 for 1 year or more. changes in antiretrovirals (arvs) within the last 12 months are allowed so long as the cpe score does not lead to a change groups * plasma hiv viral load \<50 copies / ml for preceding 12 months or longer * informed consent given by participant or legally appointed guardian exclusion criteria: * non-hiv related neurological disorders and active cns opportunistic infection as assessed by full blood count, electrolytes, creatinine, glucose, liver function tests, cryptococcal antigen, venereal disease reaction level (vdrl), mri brain scan and cerebrospinal fluid analyses for cell count, protein, glucose, culture, vdrl and cryptococcal antigen. * psychiatric disorders on the psychotic axis, current major depression, and current substance use disorder as assessed by the study enrolment questionnaire for eligibility * severe substance use disorders (within 12 months of study entry) * active hepatitis c virus (hcv) (detectable hcv rna because hcv per se can cause cognitive impairment) * history of loss of consciousness \>1 hour * non-proficient in english as assessed by the "english as a second language questionnaire" * medications known pharmacologically to interact with arvs * pregnancy as assessed by the urinary pregnancy test

Keywords: hand hiv neurology neurocognitive neuro-haart hiv associated neurocognitive disorders (hand)
real life experience with caduet in patients with cardiovascular risk factors

Conditions: Hypertension and Cardiovascular Risk Factors

Summary: to assess the effect of single pill therapy on the management of hypertension and other cardiovascular risk factors (e.g., dyslipidemia) in indian patients in whom the treating doctor has already considered that the administration of the amlodipine/atorvastatin single pill to be appropriate

patients who have been prescribed single pill caduet are eligible to participate in this study. the treating physician will obtain written informed consent from each subject or the subject's legally acceptable representative before any study-specific activity is performed. the study terminated on may 5, 2008. the decision to terminate was due to inability to achieve study timelines and undue delay in obtaining iec/irb permission at some sites. no safety or efficacy issues caused the decision to terminate.

Eligibility criteria:
inclusion criteria: patients who have been prescribed single pill caduet are eligible to participate in this study. patients will be treated in this study according to prevailing local clinical practice following the locally approved product labeled recommendations. exclusion criteria: * known hypersensitivity to dihydropyridines, amlodipine, atorvastatin, or any component of this medication, * active liver disease or unexplained persistent elevations of serum transaminases exceeding three times the upper limit of normal, * or who are pregnant, breast-feeding, or of childbearing potential who are not using adequate contraceptive measures. amlodipine/atorvastatin should be administered to women of childbearing age only when such patients are highly unlikely to conceive and have been informed of the potential hazards to the fetus.

Keywords: efficacy,safety & tolerability of caduet in patients with cardiovascular risk factors
survey of thai-muslim health status

Conditions: Diabetes; Hypertension; Hyperlipidemia

Summary: the purpose of this study was to determine the prevalence and risk factors of diabetes, hypertension, hyperlipidemia among thai muslim population aged 35-75 years.

this was a cross-sectional study conducted in bangkok and surrounding provinces. approximately 1500 participants were enrolled. study staff interviewed participants on basic demographic data, health status, physical activities, food frequency and 24-hour recall. anthropometry (body weight, height, hip and waist circumference) and physical assessment (blood pressure)were measured. ten milliliters of venous blood was drawn by venipuncture after a 12 h overnight fast for determination of fasting plasma glucose (fpg) and blood lipid concentrations (total cholesterol, triglyceride, and hdl-cholesterol). fpg was measured by the enzymatic colorimetric method with glucose oxidase.21 total cholesterol was determined by the cholesterol oxidase method and serum triglycerides concentration was determined by standardized enzymatic procedures using glycerol phosphate oxidase assay.22, 23 hdl- cholesterol was measured by enzymatic assays.24 ldl cholesterol was calculated according to the method of friedwald et al.25 all samples were analyzed when internal quality control met the acceptable criteria. intra-and inter-assay cvs were 2.01% and 3.01% for fpg, 1.87% and 4.24% for total cholesterol, 0.93% and 11.6% for triacylglycerols, and 0.99% and 1.49% for hdl cholesterol, respectively.

Eligibility criteria:
inclusion criteria: * 35 y and older muslim * free from severe communicable diseases and mental disorders exclusion criteria: * not able to complete the interviews or obtain blood samples for analysis

Keywords: thai-muslim thai-halal diabetes hypertension hyperlipidemia metabolic syndrome
estrogen and gender biased autoimmunity

Conditions: Systemic Lupus Erythematosus

Summary: this study involves research to investigate how estrogen affects women of childbearing age and its correlation to systemic lupus erythematosus. the findings from this study might help determine how body cells, called t cells, react to estrogen. the study will seek to determine if cells from women with lupus, react differently from cells in persons without lupus. we will attempt to identify genetic factors that determine the effects of estrogen on lupus cells.

this is a 3-year study. the total number of subjects enrolled will depend on the results obtained. the subjects will be at least 18 years of age and pre-menopausal. exclusion to include pregnant women, and all subjects are told not to get pregnant while on study. also, they cannot take hormones by mouth or patch while on study. the study can include healthy subjects as well. blood will be drawn (120 ml) four times a year, randomly.

Eligibility criteria:
inclusion criteria: * female subjects with lupus, and female subjects without lupus. age at least 18, not pregnant and not planning to get pregnant. exclusion criteria: * pregnant or planning to get pregnant. on hormone replacement, or birth control of any kind.

Keywords: systemic lupus erythematosus estrogen receptors t cells hormones female adult sle
checklist-guided shared decision-making for code status discussions in medical inpatients.

Conditions: Code Status Discussions With Medical In-patients

Summary: this cluster-randomized, multicenter trial is designed to investigate the effect of checklist-guided shared decision-making including decision aids and communication of expected outcome on patients' decision regarding their code status, and at the same time, if it improves decision-making quality as judged by patient's decisional comfort, patient knowledge and involvement in decision-making and patient satisfaction. patients in whom resuscitation is considered as futile will be treated separately in an ancillary project. in these patients a checklist to communicate the futility and the medical consequences will be used.


Eligibility criteria:
inclusion criteria: 1. physician level - residents on the medical wards will be the primary level of randomization. 2. patient level - any adult (\>18 years) patient that is admitted for in-hospital care will be eligible. exclusion criteria: 1. physician level - no exclusion criteria for physicians except if they refuse participation 2. patient level * patients unable to complete questionnaires or unable to follow code status discussions due to (1) intoxication, (2) paracusis; (3) serious psychiatric conditions (e.g., psychosis, depression with suicidal tendency, stupor), (4) cognitive impairment (e.g. dementia, delirium). * patients prior included in this study (i.e., patients who are hospitalized for the second time)

Keywords: code status discussion resuscitation hospitalized patient cardiac arrest
rsa study of furlong evolution with and without collar

Conditions: Hip Replacement in Osteoarthritis Patients

Summary: the aim of this study is to further investigate the clinical and radiological importance of design changes in cementless hip prosthesis. the investigators have earlier evaluated the classical furlong hac total hip prosthesis and a first design change furlong active. now a further development, furlong evolution, is to be evaluated. this prosthesis, furthermore, comes with and without a collar, and the investigators are going to randomize between the two. the investigators hypothesize that the new design will be easier to implant and will present equal or less migration than the older designs which would imply a favourable outcome in the long term. the investigators further hypothesize that the collar play no major part for the long term migration and bone remodelling. we will now do a 10 year follow up of the patients including rsa, dxa and proms


Eligibility criteria:
inclusion criteria: * primary osteoarthritis of the hip necessitating primary hip replacement * a femur considered suitable for uncemented fixation of the stem * biological age \<75 years old at the inclusion time of the study. exclusion criteria: * rheumatoid arthritis * malignant disease * severe osteoporosis * earlier fracture or operation in the hip to be operated on * peroperative fracture * ongoing corticosteroid (oral) or immunosuppressive medication * personal disorders (dementia, alcohol or drug abuse etc) suspected of making completion of the trial uncertain.

Keywords: radiostereometry total hip arthroplasty stem design