Kornimate/medical-research-clean huggingface dataset:
compare the value of prophylactic versus therapeutic breast radiotherapy in casodex

Conditions: Prostate Cancer

Summary: the primary objective of this trial is to examine the value of prophylactic versus therapeutic breast radiotherapy in casodex monotherapy induced gynaecomastia and/or breast pain. patients will receive either prophylactic radiotherapy to the breast at a dose of 12gy (as two fractions of 6 gy in consecutives days), or will not receive any radiotherapy prior to commencing casodex 150mg monotherapy.


Eligibility criteria:
inclusion criteria: * males patients aged 18 years or over on entry into the trial * patients who have non-metastatic cancer that is confirmed by histology or cytology. this primary treatment should have been completed in the last 8 weeks * the stage should be t1b/t1c/t2/t3/t4 any n category * paitents must have given written, fully informed consent to participate in the trial prior to any trial specific assessments being made * be able and prepared to comply with trial procedures and restrictions * have a life expectancy greater than 2 years exclusion criteria: * any known sensitivity to radiation therapy or any conditions which in the investigator's opinion may lead to radiation sensitivity * patients with any concurrent malignancy (except for basal cell or to-2 no mo squamous cell carcinoma of the skin). history of previous malignancy or treatment for any cancer in the past 5 years * previous history of mastectomy including a webster operation or radiation therapy to the chest area * any previous treatment with surgical or medical castration, anti-androgens, monotherapy or oestrogen therapy at any time * any evidence of pre-existing gynaecomastia or breast pain * patients with history or presence of testicular abnormalities (as casodex can potentially aggravate testicular tumours) * patients with any concurrent disease or condition that in the opinion of the treating physician, would constitute a hazard for participation in this study or may interfere with the patient's ability to comply with the scheduled visits and assessments. this includes patients whose physical build would prevent reasonable assessment of gynaecomastia * liver disease (bilirubin greater than 2.0mg/dl; ast/alt greater than 2 times the upper limit or normal) * patients taking the following drugs; terfenadine, cisapride, astemizole, cyclosporin, and warfarin are excluded from the trial due to the possibility of drug interaction * patients with a known history of alcohol abuse * concurrent treatment with any druges known to have high potential for causing gynaecomastia or breast pain, eg.spironolactone, steroid therapy, cimetidine and neuroleptic agents. * treatment with a new chemical entity within the previous 4 months or current participation in another clinical trial involving an investigational product * patients considered by the investigator to be at risk of transmitting any infection through the body or other body fluids, including acquired immue dificiency syndrome (aids) other sexually transmitted diseases or hepatitis

Keywords: casodex prostate cancer
application and evaluation of group cognitive intervention for depressed adolescents

Conditions: Community Adolescents at Risk for Depression and Suicide

Summary: cognitive behavioral therapy (cbt) is effective and cbt with parental involvement has potential in preventing and treating adolescent depression. the purpose of this study was to compare the short- and long-term effectiveness of cbt alone and cbt plus parental education for community-based adolescents at risk for depression and suicide in taiwan. it is hypothesized that the cbt alone and cbt with parental education group are more effective than the control group.

cognitive behavioral therapy (cbt) is well known for its active, directive, time-limited, and structured approach. despite an increasing prevalence of adolescent depression in taiwan, few studies have been conducted to evaluate the immediate and long-term effectiveness of cbt for community-based adolescents at risk for depression and suicide. also, little is known about the effectiveness of the involvement of parents in cbt groups. the adolescent coping with depression course (cwda) (19) is an effective cbt-oriented group intervention for adolescent depression. however, it has not been tested in specific cultural groups. the primary purpose of this study was therefore to compare the immediate and long-term effectiveness of cbt alone, cbt with parental education, and control groups for community-based adolescents at risk for depression and suicide.a quasi-experimental research design was used in this study. community-based high school students at risk for depression and suicide were recruited and assigned to one of two experimental groups or a control group. students in the experimental groups received cbt plus parental education (group a, n = 9) or cbt alone (group b, n = 10). the control group was designed as a waiting list group (group c, n = 12). both experimental groups received a follow-up session 1 year after the intervention. several outcome variables (depressive symptoms, suicidal ideation, cognitive triad, learned resourcefulness \[lr\], and salivary cortisol level) were used to determine the effectiveness of treatment.

Eligibility criteria:
inclusion criteria: * willing to participate group assignment and grant consents exclusion criteria: * unwilling to participate potential group activity and grant consents * severe physical or psychiatric disorders

Keywords: cbt, depressed and suicidal adolescents
effect of alpha lipoic acid on obesity related comorbidities

Conditions: Obesity; Cardiovascular Disease; Type 2 Diabetes

Summary: the major objective of this study is to conduct a double-blind, placebo-controlled, randomized clinical trial to assess whether oral alpha lipoic acid supplementation will decrease cardiovascular disease and type 2 diabetes risk in obese subjects.


Eligibility criteria:
inclusion criteria: * han ethnicity * bmi≥25kg/m2 * having at least one of the following risk factors: borderline hypertension (130mmhg≤sbp\<140mmhg or 85mmhg≤dbp\<90mmhg), dyslipidemia (fasting total cholesterol ≥240mg/dl or hdl-c\<40mg/dl), or impaired fasting glucose (fasting glucose levels between 6.1 and 7.0mmol/l) * 18-60 years old * not on any antioxidant vitamin supplement exclusion criteria: * pregnancy, lactation or child-bearing age without birth control device * history of hypertension, diabetes, coronary heart disease(chd), cancer or liver disease * anything that would impede the subject from complying with the ala treatment * history of psychiatric problems

Keywords: antioxidant obesity
prospective cohort study of association of insulin resistance/steatosis with hepatic fibrosis in chb and nafld

Conditions: Chronic Hepatitis B; Hepatic Fibrosis; Fatty Liver

Summary: hepatic steatosis and insulin resistance are associated with severity of fibrosis in non-alcoholic fatty liver disease (nafld) and chronic hepatitis c. however, clinical significance of steatosis and insulin resistance on fibrosis in chronic hepatitis b (chb) is not well established. the aim was to investigate the relationship between insulin resistance, hepatic steatosis, and fibrosis in patients with chb.

acoustic radiation force impulse elastography

Eligibility criteria:
inclusion criteria: * chronic hepatitis b patients * with evidences of hepatic steatosis on ultrasonography or pathology exclusion criteria: * significant alcohol consumption or other known liver diseases

Keywords: chronic hepatitis b hepatic fibrosis steatosis
click in the critical care unit

Conditions: Central Venous Catheter Thrombosis; Central Venous Catheter Related Bloodstream Infection; Catheter Complications; Catheter Blockage; Catheter Dysfunction; Central Line-associated Bloodstream Infection (CLABSI); Catheter; Catheter Infection

Summary: insertion of a central venous access device (cvad) allows clinicians to easily access the circulation of a patient to administer life-saving interventions. due to their invasive nature, cvadss are prone to complications such as infection, bacterial biofilm production, and catheter occlusion due to a thrombus. a cvad is placed in up to 97% of patients in the intensive care unit, exposing this vulnerable population to risk of nosocomial infection and occlusion. current standard of care involves use of normal saline (for cvcs and piccs) or citrate (for hemodialysis catheters) as a catheter locking solution. cvad complications remain a problem with current standard of care. 4% tetrasodium ethylenediaminetetraacetic acid (edta) fluid (kitelock sterile locking solution) possesses antimicrobial, anti-biofilm, and anti-thrombotic properties and is approved by health canada as a catheter locking solution. as such, it may be superior cvc locking solution than the present normal saline or citrate lock. to our knowledge, the efficacy of an edta catheter locking solution has not yet been investigated in the intensive care patient population. our team proposes to fill this knowledge gap by performing a multi-centre, cluster-randomized, crossover study evaluating the impact of kitelock sterile locking solution on a primary composite outcome of clabsi, intraluminal occlusion, and alteplase use in the icu of six icu's compared to the standard of care saline lock.


Eligibility criteria:
inclusion criteria: * \>18 years of age icu/hau admission * presence of a central venous catheter requiring locking. this includes cvcs, ivads, dialysis lines, and picc lines. exclusion criteria: * known or tested sensitivity to edta or edetate * confirmed or suspected pregnancy * patients who decline receiving blood products * physician, patient, or temporary substitute decision maker (tsdm) declines * currently enrolled in any other research study that may confound primary outcome measures. co-enrollment in multiple studies will be considered on an individual basis * patients who were previously enrolled in the study. patients who were enrolled in the first period are not eligible for (re-)enrolment in the second period, and patients who are enrolled in the study and transferred to another participating hospital are not eligible for (re-)enrollment at the receiving hospital. patients who had been discharged from the unit to another hospital ward and are re-admitted to the critical care unit are no eligible for re-enrollment into the study.

Keywords: ethylenediaminetetraaceticacid
pain compared between the first and the second surgery in staged btka

Conditions: Knee Osteoarthritis

Summary: postoperative pain and analgesic consumption between the first and the second surgery would be compared in patients undergoing staged bilateral total knee arthroplasty (btka).

postoperative pain and analgesic consumption is compared between the first and second total knee arthroplasty (tka) operation.

Eligibility criteria:
inclusion criteria: * patients undergoing elective bilateral staged total knee arthroplasty at a 1-week interval under spinal anesthesia, * age \<=85 * american society of anesthesiologists physical status of i to ii exclusion criteria: any contraindication to spinal anesthesia or femoral nerve block such as coagulopathy; conversion to general anesthesia; preexisting pain syndrome; abnormal liver function or renal test results; severe heart, liver, or renal disease; history of stroke or neurologic deficits; psychiatric disorder; chronic opioid use; drug dependency; allergy to study medications; inflammatory joint disease; previous surgery on or trauma of the knee; difference in preoperative vas score of ≥ 20 (at rest and at maximum knee flexion) between each side of the knee; body mass index of ≥ 40 kg/m2; and inability to comprehend the vas or to use patient-controlled analgesia (pca.
validation of belun ring gen3 deep learning algorithms with subxiphoid body sensor

Conditions: Sleep-Disordered Breathing; Sleep Architecture; Arrhythmia

Summary: hypothesis: br's gen3 dl algorithms, combined with its subxiphoid body sensor, can accurately diagnose osa, categorize its severity, identify rem osa and supine osa, and detect central sleep apnea (csa). primary objective: to rigorously evaluate the overall performance of the br with gen3 dl algorithms and subxiphoid body sensor in assessing sdb in individuals referred to the sleep labs with clinical suspicion of sleep apnea and a stop-bang score \> 3, by comparing to the attended in-lab psg, the gold standard. secondary objectives: to determine the accuracy of br sleep stage parameters using the gen3 dl algorithms by comparing to the in-lab psg; to assess the accuracy of the br arrhythmia detection algorithm; to assess the impact of cpap on hrv (both time- and frequency-domain), delta hr, hypoxic burden, and pwadi during split night studies; to assess if any of the baseline hrv parameters (both time- and frequency-domain), delta heart rate (referred to as delta hr), hypoxic burden, and pulse wave amplitude drop index (pwadi) or the change of these parameters may predict cpap compliance; to evaluate the minimum duration of quality data necessary for br to achieve osa diagnosis; to examine the performance of osa screening tools using osa predictive ai models formulated by national taiwan university hospital (ntuh) and northeast ohio medical university (neomed).


Eligibility criteria:
inclusion criteria: * provision of signed informed consent form. * clinically assessed and suspicious for osa with a stop-bang score ≥ 3. exclusion criteria: * full night pap titration study. * on home o2, noninvasive ventilator, diaphragmatic pacing, or any form of a nerve stimulator. * having atrial fibrillation-flutter, pacemaker/defibrillator, left ventricular assist device (lvad), or status post cardiac transplantation. * recent hospitalization or recent surgery in the past 30 days. * unstable cardiopulmonary status on the night of the study judged to be unsafe for sleep study by the sleep tech and/or the on-call sleep physician. if a participant did not sleep for at least 4 hours of technically valid sleep based on the belun ring method for diagnostic assessments, or a minimum of 3 hours of technically valid sleep during the diagnostic phase of a split-night study, the patient will be excluded from statistical analysis.

Keywords: obstructive sleep apnea wearable home sleep test photoplethysmography deep learning predictive ai models
transpulmonary driving pressure and intra-abdominal pressure relationship during laparoscopic surgery

Conditions: Anesthesia, General/Methods; Laparoscopy; Respiration, Artificial; Positive-Pressure Respiration; End-Expiratory Pressure, Positive; Ventilator-Induced Lung Injury

Summary: objective: the aim of this project is to evaluate how intra-abdominal pressure paired coupled with different ventilatory positive end-expiratory pressure levels affects the transpulmonary driving pressure during pneumoperiteneum insufflation for laparoscopic surgery. methodology: patients undergoing laparoscopic surgery will be included. the study will investigate the relationship between intra-abdominal pressure (iap) and transpulmonary driving pressure (tpdp) and the effect of titration of peep on their relationship. at three different levels of intra-abdominal pressure, the respiratory driving pressure (rdp) and tpdp in each subject will be measured in each subject. the same subject will undergo two different ventilation strategies. demographic data (height, weight, body mass index and sex), asa physical status (surgical risk classification of the american society of anesthesiology), number of previous abdominal surgeries, number of previous pregnancies, and respiratory comorbidities will be collected. respiratory pressures and mechanics will be recorded at each level of intra-abdominal pressure (iap) during each ventilatory strategy. the variables recorded will include: airway pressures (plateau pressure pplat, peak pressure, ppeak), the final esophageal pressure of inspiration and expiration and pulmonary stress index. mixed linear regression will be used to evaluate the relationship between different peep levels, iap and tpdp by adjusting for known confounders and adding individuals as a random factor. likewise, an analysis using a mixed linear regression model with the pulmonary stress index as a function of the intra-abdominal pressure, the ventilation regime, and a specific random intercept term for each subject will be performed.


Eligibility criteria:
inclusion criteria: * american society of anesthesiology (asa) risk scale i to iii * age \> 18 years * previously signed informed consent * undergoing laparoscopic surgery exclusion criteria: * asa ≥ iv * pregnancy * advanced liver, kidney or cardiopulmonary disease

Keywords: mechanical ventilation driving pressure protective lung ventilation
clinical and radiographic assessment of partial and complete pulpotomy in primary molars using mta

Conditions: Pulp Disease, Dental

Summary: that's comparison between partial and complete pulpotomy techniques in primary teeth


Eligibility criteria:
inclusion criteria: 1. - medically free children who will be able and cooperative in all steps of the study. 2. - asymptomatic primary molars with a deep carious lesion. 3. - vital pulp due to dental caries with no clinical sign of pulpal degeneration (spontaneous pain, fistula, mobility) prior to treatment. 3 - preliminary radiographs indicating absence of pathologic internal or external root resorption, or any evidence of inter-radicular bone destruction. 4 - absence of pre-operative pain or they will only have a short-term pain. 5 - no tenderness to percussion. 6-age ranging 4-6 years. exclusion criteria: 1- excessive bleeding during pulp amputation. 2 - non vital teeth. 3 -history of spontaneous or prolonged pain. 4 - swelling, tenderness, to percussion or palpation, or pathologic mobility. 5 - pre-operative radiographic pathology such as resorption (internal, external); periradicular or furcation radiolucency, or a widened periodontal ligament space. 6 - parent or guardians who refuse participating in the study
study to characterize effects of programming in scs patients undergoing a temporary trial

Conditions: Chronic Pain

Summary: this is a prospective, multi-center, non-randomized, exploratory, single-arm study characterize the effects of programming spinal cord stimulation (scs) in patients undergoing a boston scientific (bsc) spinal cord stimulation (scs) temporary trial


Eligibility criteria:
key inclusion criteria: * study candidate is undergoing a spinal cord stimulation (scs) trial of bsc neurostimulation system, per local directions for use (dfu). * subject signed a valid, institutional review board (irb)-approved informed consent form. * subject is 18 years of age or older when written informed consent is obtained. key exclusion criteria: * subject meets any contraindication in bsc neurostimulation system local directions for use (dfu).

Keywords: stimulation chronic pain back pain leg pain
study of brain function evaluation system for acute and prolonged disorders of consciousness

Conditions: Disorder of Consciousness

Summary: the research focuses on establishing a system for detecting loss of consciousness, developing clinical prognostic and awakening-related brain function testing criteria.

a framework for the acquisition of neural features, feature selection and mechanism analysis of consciousness deficits in patients with acute and prolonged disorders of consciousness(doc). based on the multimodal data of three types of patients with doc, the investigators established a comprehensive scientific collection of brain function features of acute and prolonged consciousness disorders; revealed the key neural nodes and circuits of consciousness deficits, and elucidated the neural mechanisms of consciousness deficits in patients with prolonged consciousness disorders from eeg time-frequency-spatial features;

Eligibility criteria:
admission criteria for patients with prolonged disorders of consciousness inclusion criteria: 1. age 14-60 years; 2. in accordance with the diagnostic criteria of unresponsive arousal syndrome or minimally conscious state by international research; 3. brain trauma, stroke and hypoxic-ischemic encephalopathy lead to disturbance of consciousness; 4. right-handed； 5. the patient's family members signed the informed consent form; exclusion criteria: 1. the history of mental illness and a history of hearing impairment; 2. intracranial arterial clamp, pacemaker and other metal implants; 3. during the experiment, sedatives and other drugs that affect the excitability of the cortex; 4. the presence of uncontrolled seizures or involuntary movements; admission criteria for patients with acute disorders of consciousness inclusion criteria: (1)age 14-60 years; (2）meets diagnostic criteria for coma recognized in international studies； (3)the gcs score was less than 8; (4)brain trauma, stroke and hypoxic-ischemic encephalopathy lead to disturbance of consciousness; (5) right-handed； (6)the patient's family members signed the informed consent form; exclusion criteria: 1. the history of mental illness and a history of hearing impairment; 2. intracranial arterial clamp, pacemaker and other metal implants; 3. during the experiment, sedatives and other drugs that affect the excitability of the cortex; 4. the presence of uncontrolled seizures or involuntary movements; admission criteria for patients with acute disorders of consciousness; 5. no spontaneous breathing; 6. status epilepticus; 7. need emergency neurosurgical treatment can not cooperate with the examination;

Keywords: brain function test
inhaled corticosteroids in u-5 children with acute respiratory infection in uganda: a randomised trial

Conditions: Bacterial Pneumonia; Viral Pneumonia; Acute Asthma

Summary: the purpose of this study is to find out whether adjunct treatment with inhaled corticosteroids lead to faster improvement and reduce mortality of children under 5 years of age admitted to hospital with alri.

pneumonia is one of the common causes of serious illness in children under 5 years of age. it is one of the common causes of admission to hospital and the commonest cause of death in ugandan children under 5 years of age. the signs of pneumonia also occur in children with asthma making it difficult to differentiate the two. other researchers have found that one of two children under five years of age with pneumonia have asthma. wheeze which is regarded as a sign of asthma is heard in only one of three children with asthma, implying that many children with asthma especially in the first few years of life are less likely to be diagnosed. they are also less likely to receive inhaled steroids, the recommended treatment for asthma. failure to administer asthma medicines may contribute to delayed improvement and increase the risk of death. the study hypothesizes that use of inhaled corticosteroids in addition to standard treatment in children hospitalized with alri will be associated with reduced morbidity and mortality and that the improvement will be more marked in children diagnosed with asthma posthoc. outcomes: reduction in case fatality, time to normalization of respiratory rate, time to normalization of oxygen saturation, duration of hospitalisation.

Eligibility criteria:
inclusion criteria: * children aged 2 to 59 months with cough and or difficult breathing exclusion criteria: * presence of a serious concurrent illness such as meningitis, children with congenital or acquired heart disease severe anaemia measles pneumonia foreign body inhalation a confirmed diagnosis of pulmonary tuberculosis

Keywords: children u-5 alri inhaled corticosteroids