Kornimate/medical-research-clean huggingface dataset:
physical activity on postural stability and coordination in children with posterior fossa tumor

Conditions: Posterior Fossa Tumor; Medulloblastoma, Childhood

Summary: medulloblastoma is a rapidly-growing tumor of the cerebellum, this area controls balance, posture and sophisticated motor functions like finer hand movements, speech, and swallowing. it has been reported that those children fall frequently so the purpose of this study is to investigate the effectiveness of balance and coordination training in these children.

the effects of physical exercise training interventions for childhood cancer participants are not yet convincing due to small numbers of participants and insufficient study methodology. more and high-quality evidence is needed in order to be able to draft exercise and physical activity guidelines for this population. despite the positive results of exercise interventions in adult cancer patients, the evidence for benefits in childhood cancer patients is limited. there are two main objectives: 1. to investigate the effectiveness of pilates core stability exercises program. 2. to investigate the effectiveness of humac balance and tilt system. secondary objectives: 1. the effectiveness of coordination training in children with posterior fossa tumors. 2. the comparison between balance and coordination training and which of both trainings has more effect. this study will take place in a pediatric oncology setting, children's cancer hospital egypt(cche), in outpatient setting. patients will be evaluated for their balance and coordination at initial presentation, during treatment, and during follow-up after end of treatment at cche. also patients will receive balance and coordination training, before each chemotherapy cycle-maximum one week- given the patient is in good state. sixty children with posterior fossa tumors of both sexes will participate in this study. they will be selected from cche. they will be randomly assigned into 3 groups of equal number.

Eligibility criteria:
inclusion criteria: 1. children with posterior fossa tumors during follow up. 2. children between 5-12 years old. 3. time elapsed since the start of treatment more than 4 months in order to be in maintenance phase. 4. they can understand verbal command. 5. children with no visual, auditory or perceptual disorders. 6. children are already treated surgically. exclusion criteria: * children who have one or more of the following criteria will be excluded from the study: 1. children with a genetic disorder or mental retardation. 2. children with a chronic lung disease. 3. sever cardiomyopathy (ejection fraction \<40%, ischemia and angina pectoris at rest). 4. children with a neuromuscular disease not related to tumor.

Keywords: physical activity postural stability coordination posterior fossa tumor
the effects of traditional chinese medicine mouthwash solutions on the oral health of leprosy patients

Conditions: Leprosy; Hansen's Disease; Xerostomia; Plaque

Summary: the purpose of this study is to treat with traditional chinese medicine mouthwash, and through the research of dental plaque detection and xerostomia questionnaire and traditional chinese medicine treatment mechanism.

the study will recruit 58 patients who are hospitalized at lo-sheng sanatorium, ministry of health and welfare. investigators will use xerostomia questionnaire and pli examination to collect the subject's data. separate subjects in to two group randomly. the control group will use the traditional chinese medicine mouthwash, and the other group will use the dilute 50 times of traditional chinese medicine mouthwash. every 7 days will record the pli value and conduct a xerostomia questionnaire, until 21 days.

Eligibility criteria:
inclusion criteria: * residents of lo-sheng sanatorium of the ministry of health and welfare, taiwan * compliant with the presence of more than four teeth in each of the upper and lower four regions * those who have not used antibiotics and mouthwash two months before the test exclusion criteria: * moderate to severe dementia * cdr (clinical dementia assessment scale) is greater than or equal to 2 points or more * those with a score of less than 17 on the mmse simple mind scale * nasogastric tube inserters * those who are allergic to mouthwash * those who are on course of antibiotics and steroids * those who have had dental cleansing within one month

Keywords: leprosy hansen's disease (hd) traditional chinese medicine mouthwash oral health xerostomia plaque index, pli
study to evaluate the safety and efficacy of csb-001 ophthalmic solution 0.1% in subjects with limbal stem cell deficiency

Conditions: Limbal Stem Cell Deficiency

Summary: this study will enroll subjects with qualifying limbal stem cell deficiency (lscd). all subjects will receive csb-001 investigational drug in either one or both study eyes. the study is comprised of two identical phases (dosing phase i and ii) of test article dosing separated by a 31- to 40-day period, the dosing holiday, where no test article is administered. dosing phase ii is followed by an observational, noninterventional phase (observation phase).


Eligibility criteria:
inclusion criteria: * have an area of the central 5 mm zone of cornea affected, presence of at least one clinical sign observed by slit-lamp examination with white light and/or cobalt blue light, fluorescein, and a wratten filter, and at least one clinical sign observed with as-oct. * if dosing with acthar at time of screening visit, must have a history of stable dosing for approximately 8 weeks, plan to maintain the same acthar treatment dose and regimen, and have demonstrated little to no improvement in severity of lscd. * sponsor written confirmation of qualifying lscd diagnosis. * inflammation associated with lscd or other non-infectious inflammation that will not interfere with subject's participation. exclusion criteria: * any active ocular infection (bacterial, viral, fungal, or protozoan) in either eye. * ocular surgery within 30 days of day 0 where investigator assesses that healing is not considered complete/stable. * planned ocular surgery on or before week 20 visit. * presence or history of any ocular or systemic disorder, condition, or procedure that might hinder the efficacy of the study treatment or its evaluation, or could interfere with the interpretation of study results, in the opinion of the investigator. note: other inclusion/exclusion criteria apply.
inadvertent hyperventilation during intraoperative care in neonates

Conditions: Neonatal Disorder

Summary: in order to evaluate current anesthetic practice in the care of preterm infants and neonates, the investigators will retrospectively review surgical procedures in infants who are less than 60 weeks post-conceptual age in which an arterial cannula was placed intraoperatively or in situ upon arrival in the operating room. they will evaluate the mode of ventilation (pressure or volume-controlled), tidal volume or peak inflating pressure, the level of peep, inspired oxygen concentration (fio2), and respiratory rate used during the procedure to determine the average minute ventilation.


Eligibility criteria:
inclusion criteria: * neonates (\<60 weeks post-conceptual age) undergoing non-cardiac operative procedures in which arterial access is generally present (exploratory laparotomy or thoracotomy) exclusion criteria: * none
efficacy of mobile phone short message service (sms) reminder and consultation on asthma control

Conditions: Asthma

Summary: asthma is the disease being studied. the main objective of this study is to assess the clinical efficacy of mobile phone short message service (sms) reminder and consultation on the self-management and outcomes of poorly controlled asthma which is first diagnosed in a time period of 3 months. the secondary objective is to explore the cost-benefit and cost-effectiveness of the proposed intervention. aims: the main aim of this study is to assist asthma patients to practice asthma self-management at home by sending reminders and responding to patients' consultations with mobile phone short message service (sms), which will eventually help them to control their asthma, and prevent asthma exacerbation. thus, the ultimate goal of this proposed study is to improve patient health outcome via enhancing patient-physician interaction through mobile phone short message service (sms) that is low-cost and could be followed easily by the patients and their physicians. the hypothesis is that asthma patients who receive weekly text message reminders to educate them and reinforce adherence will have better asthma outcome, such as asthma control, while the intervention integrating patient consultation and reminders by sms improve asthma outcome even more. the investigators further hypothesize that these subjects under intervention will have an improvement in secondary measures including quality of life and patient satisfaction. the investigators also anticipate that such an approach in asthma management will be cost-effective.

after examined for their eligibility and recruited into this study at outpatient service, all participants have their case records which contain their baseline data and receive the same standard asthma education(including basic knowledge about asthma, how to use their medicine, what to do when an asthma attack happens and when to come back for their disease review and so on). each patient is given a paper asthma diary and a peak expiratory flow(pef) measurer for free. in addition, they are told what intervention they will receive and revised face-to-face one month after the beginning of intervention. after the 3-month study period, when they return to the hospitals, they will return the asthma diaries, be asked to fill in the questionnaires and take pulmonary function tests.

Eligibility criteria:
inclusion criteria: 1. physician diagnosed uncontrolled or partly-controlled asthma by global initiative for asthma(gina) standard. 2. at least 6 months asthma history. 3. ownership of a mobile phone and currently using the text messaging service. 4. age between 18 and 65 years old. 5. willingness to participate in this study. 6. willing to sign the written informed consent to take part in the study. exclusion criteria: 1. inability to provide written informed consent or to fill in the paper asthma diary. 2. a history of smoking cigarettes for greater than ten pack years. 3. other current or a history of severe comorbidity. 4. being in other clinical trials.

Keywords: asthma management sms reminder sms consultation
3 formulations of hib-mency-tt vaccine & 1 formulation of hib-menc-tt vaccine compared to licensed meningococcal serogroup c conjugate vaccine, each administered at 2,3,4 mths of age

Conditions: Haemophilus Influenzae Type b; Neisseria Meningitidis

Summary: this study evaluated the safety and immunogenicity of 3 formulations of hib-mency-tt vaccine and 1 formulation of hib-menc-tt vaccine compared to a control group receiving licensed meningococcal serogroup c conjugate vaccine, each administered at 2, 3, and 4 months of age. antibody persistence and immune responses to booster vaccinations were additionally assessed at 12 to 18 months of age.

primary \& booster vaccination study to evaluate the immuno,reacto \& safety of 3 diff. formulations of gskbio'combined haemophilus influenzae typeb-meningococcal serogroups c \& y-conjugate vaccine \& one formulation of gskbio' haemophilus influenzae typeb-meningococcal serogroup c conjugate vaccine each given concomitantly with infanrix penta (dtap-ipv-hepb vaccine), vs meningitec meningococcal serogroupc conj.vaccine) given concomitantly with infanrix hexa (dtap-ipv-hepb-hib vaccine) in infants according a 2-3-4 mth schedule

Eligibility criteria:
inclusion criteria: * healthy infants without major congenital illness, immunosuppression, or chronic disease born at 36 to 42 weeks of gestation, between 6 and 12 weeks of age at enrollment, and vaccinated against hepatitis b at birth. exclusion criteria: * infants should not have received any investigational drug, vaccine, chronic immunosuppressants, or immunoglobulin or blood products.

Keywords: invasive bacterial disease caused by hib neisseria meningitidis serogroups c & y
physiological vs right ventricular pacing in patients with normal ventricular function post-tavi

Conditions: Transcatheter Aortic Valve Implantation; Physiological Pacing; Right Ventricular Pacing; AV Block

Summary: single-center randomized trial in patients with pacing indication (av block) after tavi (transfemoral aortic valve implantation) and lvef\> 50%, that aims to study the percentage of patients who improve at 12 months in a combined clinical endpoint.

there is currently no evidence of the best mode of definitive pacing after tavi in patients with preserved systolic ventricular function and av block. through this study, investigators intend to elucidate the best post tavi pacing strategy, comparing the effect of right apical pacing vs. physiological pacing on the evolution of both echocardiographic and clinical parameters. investigators will include 24 patients without ventricular dysfunction (lvef\> 50%) and with av block pacing indication after tavi. patients will be randomized to 2 types of pacing (parallel randomized trial): physiological or right ventricular pacing (conventional). phys-tavi trial will analyze the following parameters in the 2 groups: survival; nyha class; distance in the 6-minute walking test; hospital admissions; left ventricular function; echocardiographic asynchrony (strain and flash septal); ntprobnp; and quality of life/symptoms with the kansas city cardiomyopathy questionnaire test (kccq-12) clinical, and echocardiographic follow-up will be performed for 1 year.

Eligibility criteria:
inclusion criteria: * successful implantation of tavi according to varc-2 criteria. * indication of cardiac pacing due to av block according to esc guidelines. * lvef\> 50%. * the patient must indicate their acceptance to participate in the study by signing an informed consent document. exclusion criteria: * ventricular dysfunction: lvef \<50%. * transapical tavi. * participating currently in a clinical investigation that includes an active treatment. * patients with left bundle branch block but without indication of pacing (av block). * life expectancy \<12 months.

Keywords: tavi physiological pacing av block
international survey of childbirth-related trauma - swedish part

Conditions: Childbirth-related PTSD; PTSD; Postnatal Depression; Fear of Childbirth; Post Traumatic Stress Disorder; Postpartum Sadness

Summary: the goal of this cross-sectional observational study is to analyze childbirth-related ptsd, traumatic birth experiences and stress symptoms postpartum. the main questions it aims to answer are: * what is the prevalence of traumatic birth experiences, ptsd and stress symptoms in a swedish postnatal sample? * what are the risk factors for postnatal mental ill-health? additional goals are to make cross-cultural translations of the instruments city bits and birth satisfaction scale - revised. participants will answer an online surveys including several instruments measuring postnatal stress and mental ill-health.


Eligibility criteria:
inclusion criteria: having given birth 6-16 weeks previously - exclusion criteria: having given birth to a child that did not survive -
accuracy of ultrasound for detecting residual fragments during rirs

Conditions: Stone, Kidney; Ultrasound Therapy; Complications

Summary: the purpose of this study is to assess the accuracy of ultrasound and traditional fluoroscopy to find the residual fragments before retrograde intrarenal surgery is complete. this would ultimately limit the need for radiation exposure and improve the quality of clinical care given to patients and healthcare teams.

ultrasound is currently gaining popularity as an alternative imaging modality for the diagnosis and treatment of urolithiasis. however, the benefit of ultrasound on the diagnostic accuracy of detecting residual fragments during retrograde intrarenal surgery (rirs) has never been evaluated in a randomized study. its use would reduce radiation exposure for patients and care team members as well as improve stone free clearance rates for surgery. therefore, the investigators plan to conduct a randomized trial to assess the diagnostic accuracy of ultrasound and fluoroscopy in conjunction with endoscopic examination for detecting residual stone fragments during retrograde intrarenal surgery. after admission, approximately 172 subjects will be randomized in a 1:1 ratio to receive ultrasound or fluoroscopy before completing rirs. subsequently, four weeks after the operation, the investigators will compare with routine low-dose non-contrast computed tomography as a gold standard for detecting residual fragments. if ultrasound is more accurate than fluoroscopy in detecting residual fragments, the investigators will encourage this approach as it can reduce radiation exposure for patients and healthcare professionals.

Eligibility criteria:
inclusion criteria: * patients over the age of 18. * consecutive patients with a diagnosis of renal stone or ureteral stone with a plan to undergoing rirs for stone removal. exclusion criteria: * patients who decline informed consent. * pregnancy * kidney transplantation * ectopic kidney * patients undergoing concurrent bilateral stone removal surgery. * patients whose pain cannot be controlled when presenting at the emergency department.

Keywords: residual stone ureteroscopy ultrasound diagnostic accuracy
association of fgf-23 and parathyroid hormone (pth) in dialysis patients

Conditions: End-Stage Renal Disease

Summary: the purpose of this study is to determine how levels of this newly-discovered hormone, called fgf-23, changes in the blood in response to a high calcium dialysis bath during a hemodialysis (hd) treatment, and how this relates to changes in the calcium and pth levels. we are also studying the effects of dialysis and inflammation on the levels of fetuin a. we intend to prospectively study a cohort of end stage renal disease (esrd) patients on hemodialysis in order to determine whether fdf-23 levels independently affect non-suppressible pth levels. the relationship between fetuin a and inflammatory markers will also be determined. by dialyzing patients on 3.5 meq/l calcium dialysate bath, we seek any relationship between ionized calcium, fgf-23 and pth.

the goal of this study is to ascertain whether there is a regulatory relationship between the novel phosphorus-regulating polypeptide fibroblast growth factor-23 (fgf-23), ionized calcium (ica), and parathyroid hormone (pth) levels. in addition, we will determine if there is an inverse relationship between fetuin a levels and inflammatory markers, interleukin 6 (il-6) and c-reactive protein (crp), during a hemodialysis treatment. all patients participating in this study will be off zemplar and/or sensipar for a washout period of approximately 4 weeks as these medications will interfere with the study. patients will go through one designated research hemodialysis time for a blood draw. blood draws will be taken during 4 separate intervals at 0, 45, 90 and 150 minutes. at each interval, 4 tubes of blood will be drawn. there are no further required blood draws once each designated research hd session has been completed. at the conclusion of the designated research hd session, vitamin d analogue (zemplar®) and/or cinacalcet (sensipar®) will be restarted, and the dose will be adjusted to reflect the subject's recent biochemical markers (ca, phos, and ipth).

Eligibility criteria:
inclusion criteria: * 18 years or older * chronic hemodialysis for more than 3 months * ipth levels ≥ 300 pg/ml in the absence of therapy: cinacalcet (sensipar ®) and/or 1,25 vitamin analogues (zemplar®) * corrected ca ≥ 8.4 mg/dl at time of enrollment * ability to stay at least 3 hours during hemodialysis treatment exclusion criteria: * pediatric patients (age ≤ 18 years) * those unable to give informed consent * dialysis treatment for less than 3 months, or pre-emptive kidney transplantation * inability to stay more than 3 hours during a single hemodialysis treatment period
effects of motive-oriented therapeutic relationship in the early-phase treatment of borderline personality disorder

Conditions: Borderline Personality Disorder

Summary: the present research aims at examining the effectiveness of a specific set of therapist relational interventions and attitudes, called the motive-oriented therapeutic relationship (motr), based on plan analysis (caspar, 2007) in the early-phase treatment of patients diagnosed with borderline personality disorder. the investigators intend to include n = 80 outpatients diagnosed with borderline personality disorder, consulting at the outpatient personality disorder program of the karl jaspers clinical unit, in collaboration with the institute of psychotherapy, at the department of psychiatry-chuv, university of lausanne and in collaboration with the university of berne, switzerland. patients are assigned by chance to two treatment conditions 1) control condition (general psychiatric management; gunderson \& links, 2008) and 2) motr-condition. the investigators hypothesize better results in the motr-condition, as compared to the control condition in terms of symptom reduction pre-post. the conduct of the study represents a significant contribution to the understanding and enhancement of relationship aspects in the treatment of patients diagnosed with borderline personality disorder which may be of potential benefit for these patients.


Eligibility criteria:
inclusion criteria: * dsm-iv borderline personality disorder; * between 18 and 65 yrs of age exclusion criteria: * dsm-iv psychotic disorders, * mental retardation, * substance abuse in the forefront
a dose-ranging study of the safety and effectiveness of jnj-42160443 as add-on treatment in patients with low back pain

Conditions: Low Back Pain; Low Back Pain, Recurrent

Summary: the purpose of this study is to compare the safety and effectiveness of different doses of jnj-42160443 with placebo in the treatment of chronic, moderate to severe low back pain patients with a diagnosis of chronic low back pain.

this is a randomized (study drug assigned by chance), double-blind (neither the physician nor the patient knows the name of the assigned drug) study to evaluate the safety and effectiveness of different doses of jnj-42160443 compared with placebo in the treatment of patients with a diagnosis of chronic low back pain who have moderate to severe, chronic low back pain that is not controlled by standard pain medications. jnj-42160443 (10 mg/ml) or matching placebo given as a subcutaneous (sc) (under the skin) injection (inj) once every 4 weeks (wks); one of four jnj-42160443 doses (1 mg every 4 wks; 3 mg every 4 wks; 6 mg loading dose on day 1 followed by 3 mg every 4 wks; or 10 mg every 4 wks, or matching placebo for up to 104 wks (12-wk double-blind efficacy period + 92-wk double-blind extension period).

Eligibility criteria:
inclusion criteria: * diagnosis of chronic low back pain exclusion criteria: * pain with radiation to the extremity and with neurologic signs * history within the past year of any of the following: seizure disorder * intrathecal therapy and ventricular shunts, mild or moderate traumatic brain injury, stroke, or transient ischemic attack, meningitis * history of brain injury within the past 15 years consisting of \>= 1 of the following, or with residual sequalae suggesting transient changes in consciousness: brain contusion, intracranial hematoma, either unconsciousness or posttraumatic amnesia lasting more than 24 hours * history of epilepsy or multiple sclerosis * current diagnosis of fibromyalgia, complex regional pain syndrome (including reflex sympathetic dystrophy or causalgia), acute spinal cord compression, bowel or bladder dysfunction as a result of cauda equine compression, back pain caused by secondary infection, or pain caused by confirmed or suspected neoplasm * any new or unresolved neurologic deficits, including progressive deficits, within 6 months before screening

Keywords: jnj-42160443 low back pain-related pain moderate to severe, chronic pain