Kornimate/medical-research-clean huggingface dataset:
health-related quality of life in patients with dupuytren's disease

Conditions: Dupuytren's Contracture

Summary: main research questions: we want to measure the change in quality of life in dupuytren's disease patients who do and do not undergo surgery. also, we want to test the validity of health related quality of life measurements in patients with dupuytren's disease. why is this research important? some patients with dupuytren's contracture require excision surgery or palmar fasciectomy. other patient's with dupuytren's contracture do not require surgery; however, these patients may need surgery in the future. no studies have reported the health-related quality of life of patients with dupuytren's disease whether related to surgical intervention or not. what is being studied? we are studying the difference and change in health-related quality of life in patients suffering from dupuytren's disease who require excision surgery and do not require surgery.

previous research on dupuytren's disease has not reported the health-related quality of life (hrql) of patients' whether related to surgical intervention or not. the primary objective of this study is to measure the change in hrql in dupuytren's contracture patients who do and do not undergo palmar fasciectomy. health related quality of life will be measured using the 1) health utilities index mark iii (hui3); 2) short form-36 (sf-36); and the 3) michigan hand outcomes questionnaire (mhq). the secondary objective is to look at the measurement properties, including the reliability and responsiveness, of each of the three hrql instruments when they are used in patients with dupuytren's contracture. we will also assess the concurrent validity of each of the hrql instruments.

Eligibility criteria:
inclusion criteria: * patients who have the diagnosis of dupuytren's disease * able to comprehend english to complete the self-reported questionnaires * willing to provide informed consent. exclusion criteria: * patients who have had previous dupuytren's contracture surgery on the same hand * patients who have carpal tunnel syndrome, rheumatoid arthritis, connective tissue disorder, tenosynovitis, or another condition that could affect quality of life * patients who are under the age of 18 years.

Keywords: health-related quality of life dupuytren's disease health utilities index short form-36; michigan hand outcomes questionnaire
use of adjustable gastric band in adolescents

Conditions: OBESITY

Summary: this study is to investigate the use the adjustable gastric band for the treatment of obesity in adolescents.

weight loss is related to the amount of energy or fuel obtained from the kinds and amounts of food eaten. when the amount of exercise and dieting uses less fuel than the amount taken in, the excess is stored as fat. the adjustable gastric band used in this study is a tool to help the participant loose weight along with healthy eating, diet and exercise. this study involves minimally invasive laparoscopic surgery to place the adjustable band around the upper part of the stomach to make a smaller stomach or pouch about the size of a golf ball. one end of the band ends with a flat balloon that goes around the upper part of the stomach. the opening from this small stomach can be changed to allow more or less food into the intestine depending on the amount eaten and the amount of weight lost. the other end of the of the band ends in a filling port through which saline solution is pumped with a needle through an attached tube to inflate or deflate the balloon. the filling port is attached to the wall of the abdomen under the skin. because the flow of food is regulated by the band, most people feel full faster. this is how the appetite for food is controlled and the why the person is likely to eat less with the band in place. food is digested through the normal digestive process.

Eligibility criteria:
inclusion criteria: bmi: female: ≥ 27 - ≥ 33 male ≥ 26 - ≥ 30.5 exclusion criteria: * •hypertension: systolic blood pressure (sbp) of 140 mm hg * hyperlipidemia: hyperlipidemia depends on * obstructive sleep apnea: * metabolic syndrom: the presence of any three of the following: abdominal obesity - dimensons for children? triglycerides -cholesterol - * fasting glucose * blood pressure * overweight * non-surgical means of weight reduction failure of * significant psychopathology (absence of ) that could limit the subject's ability to understand the procedure, comply with medical, surgical, and/or behavioral recommendations, as documented during screening assessment; * agrees to refrain from any type of reconstructive surgery that would affect body weight such as abdominal lipoplasty or liposuction, mammoplasty, or removal of excess skin for three years following sagb placement; and * candidate for surgical weight loss intervention (i.e., meets accepted health criteria for major surgery.
effect of msd on fcr among gastric cancer survivors

Conditions: Stomach Cancer；Clinical Control Trial

Summary: the goal of this clinical trial is to explores the effect of marital self disclosure intervention on fear of cancer recurrence and dyadic coping ability in gastric cancer survivors and their spouses. the main questions are: what is the level of fear of cancer recurrence among gastric cancer survivors and their spouse? what is the level of dyadic coping ability among gastric cancer survivors and their spouse?what is the effect of marital self-disclosure intervention on fear of cancer recurrence and dyadic coping ability in the gastric cancer survivors and their spouses? participants will accept the intervention of marital self disclosure for 4 times (4 cycles of chemotherapy) with different topics. researchers will compare with control group to see if the level of fear of cancer recurrence and dyadic coping ability will be improved.


Eligibility criteria:
inclusion criteria: * the disease meets the diagnostic criteria of "guidelines for diagnosis and treatment of gastric cancer"(department of medical affairs, 2019), the preoperative gastroscopy and pathological diagnosis are advanced gastric cancer, and the postoperative pathological classification is type ii, iii or iv * age ≥ 18 years * able to write and oral communicate effectively by themself * the main caregiver is their spouse * clear consciousness, no understanding barriers * agree to participate in this study exclusion criteria: * history of receiving a structured psychological intervention from a psychiatrist or a psychologist * cognitive disorders or psychiatric disorders (according to the dsm-v) * severe visual, hearing and speech impairment * with previous or concurrent malignant tumors * with severe complications, such as gastrointestinal obstruction, perforation, etc.

Keywords: cancer survivors；stomach；marital therapy
investigation of the clinical outcomes of endocrowns manufactured from three different materials

Conditions: Gross Material Loss in Endodontically Treated Upper and Lower Molars; No Systemic Infection; Gingival Steps Should be at Gum Level

Summary: the goal of this clinical trial is to examine the durability of endocrowns, created using various materials and manufacturing techniques with a fully digital workflow, and their ability to maintain functionality and aesthetics in the oral cavity. the main questions it aims to answer were does effect of different materials on clinical success?

based on the power analysis, it was determined that restorations would be applied to 11 teeth in each of the three material groups (lithium-disilicate reinforced glass-ceramic, polymer infiltrated ceramic, and 3d-printed permanent hybrid resin) as well as the control group (n=11). a total of 33 teeth received endocrown restorations. additionally, 11 patients were directly restored with composite resin in molar teeth with mod cavities. the digital impressions of the patients receiving endocrown restorations were recorded using an intraoral optical scanner and sent to a specialized dental laboratory. for two of the groups (lithium disilicate-reinforced glass-ceramic, polymer infiltrated ceramic), restorations were fabricated using block milling, while for the third group (permanent hybrid resin), restorations were produced through 3d printing. the restorations were cemented adhesively. the restorations were evaluated using the modified fdi and modified usphs criteria at baseline (0) and at the 6-month follow-up, and the data were subjected to statistical analysis. at the 6-month evaluation, a statistically significant difference in color match was found between the groups based on the modified fdi criteria, whereas no statistically significant differences were observed for any of the modified usphs criteria. all endocrowns produced with the three different materials survived and showed clinical success at the 6-month follow-up. nevertheless, additional clinical studies with extended follow-up durations are required.

Eligibility criteria:
inclusion criteria: * must be a lower or upper molar tooth * must be periodontal healthy * there must be at least two axial walls in the relevant tooth * gingival steps should be at gum level * there must be neighboring teeth mesial and distal to the relevant tooth. * the place where it occludes must be the opposing tooth and the tooth must be a natural or filled tooth without a prosthesis. * no systemic acut or chronic conditions (thyroid disease, alzheimer's disease, insulin dependent diabetes, etc.) exclusion criteria: * inadequate oral hygiene, bleeding on probing, pocket deeper than 3 mm mobility presence * sensitivity to percussion after root canal treatment * insufficient enamel tissue remaining in the relevant tooth * presence of radiographically abnormal periodontal space * teeth with inadequate bone support * teeth with root resorption and fracture

Keywords: endodontic treatment cad-cam endocrown
auricular acupuncture vs. sham procedure for pain control after knee arthroplasty

Conditions: Postoperative Pain

Summary: aim of the study to investigate whether auricular acupuncture (aa) will reduce postoperative pain and analgesic requirement in comparison with sham aa in patients after elective knee arthroplasty design prospective randomized controlled blinded clinical trial participants: * patients \ 50 years old * scheduled for knee arthroplasty under general anesthesia with \< 120 minutes duration * without previous opioid medication * able to give informed consent outcome measures * postoperative analgesic requirement * incidence of side effects * physiological parameters


Eligibility criteria:
inclusion criteria: 1. patients with an american society of anesthesiologists physical status of i to iii scheduled for elective knee arthroplasty under general anesthesia 2. surgery time does not exceed 120 minutes 3. patients without previous opioid medication 4. patients ranged 50-80 years old 5. patients who have given written informed consent exclusion criteria: 1. recidivist alcoholics 2. local auricular skin infection 3. age \ 80 years 4. surgery time more than 120 minutes 5. intraoperative complications (bleeding, required blood transfusion more than 6 units of packed cells, cardiovascular instability, required catecholamines) 6. patients who consumed opioid medication at least 6 months before surgery 7. patients with prosthetic or damaged cardiac valves, intracardiac and intravascular shunts, hypertrophic cardiomyopathy and mitral valve prolaps (risk of bacterial endocarditis according to guidelines of aha) 8. patients who are unable to understand the consent form 9. history of psychiatric disease
zinc and iron in children with short stature

Conditions: Zinc; Deficiency With Anemia

Summary: short stature is defined as height below 3rd centile or less than two standard deviations below the median height for that age and sex according to the population standard zinc and iron have important role in growth for children

short stature is defined as height below 3rd centile or less than two standard deviations below the median height for that age and sex according to the population standard. approximately 3% children in any population will be short, amongst which half will be physiological (familial or constitutional) and half will be pathological. it is estimated that approximately 60%-80% of all short children at or below 2standerd deviation fit the definition of idiopathic short stature. the growth and development of human require an adequate supply of many different nutritional factors. nutritional deficiencies causing short stature include: those associated with stunting as: protein and zinc, nutrient associated with rickts as :vitamin d, and those with bone abnormalities as: cupper,zin,and vitamin c insufficient nutrition tends to lead to short stature with a delayed pattern of growth. under-nutrition can be isolated (eg, caused by inadequate food supply or self-imposed restriction, such as fear of obesity), or it may be a component of an underlying systemic disease that interferes with food intake or absorption, or increases energy needs. the hallmark of under-nutrition is low weight-for-height . trace elements are dietary mineral that are present in very minute quantities (less than 0.01%),they divided into three groups (who classification): essential elements such as iodine and zinc ,probably essential elements such as manganese and silicon , potentially toxic elements such as fluoride,lead,cadmium, mercury, \& lithium. trace elements play significant functions as growth,oregulation of gene expression, immunity,the endocrine system, brain development, and the cell protection system. an adequate micronutrient intake is crucial for health, particularly in infants, children and adolescents ,deficiency in micronutrients can affect growth and development, particularly during periods of rapid growth.

Eligibility criteria:
inclusion criteria: * • children of both sexes. * age range: 4-18 years. * patients fulfilling criteria of short stature. * height is 2 standard deviations below normal . * initial height below the third percentile on egyptian growth chart. • number of patients: will include 50 cases exclusion criteria: * skeletal dysplasia. * chromosomal anomalies
psychosocial support for patients with takotsubo syndrome

Conditions: Takotsubo Cardiomyopathy

Summary: the study hypothesis is that participants enrolled in a virtual takotsubo support group will have significantly less anxiety at one year.

takotsubo cardiomyopathy, sometimes termed takotsubo syndrome and "broken heart syndrome," typically presents with symptoms remarkably similar to acute myocardial infarction (mi; heart attack): debilitating chest pain, shortness of breath, and a feeling of doom, among others. takotsubo was first identified in 1990 in japan. most cases occur in older women. during the acute phase, the heart spontaneously undergoes "apical ballooning," changing shape to resemble a "takotsubo," a japanese octopus trap. in approximately two-thirds of cases, takotsubo is precipitated by an intense emotional or physical "trigger." typically, the heart spontaneously reverts to its previous shape within about a month. initially, it was thought that recurrence was rare. however, more recently, recurrences have been reported in 3-15% of cases. many patients experience a variety of debilitating cardiac and psychological symptoms long after the initial presentation. there is no known way to prevent a recurrent event and patients are typically anxious about the possibility. since its inception as a diagnosis, one of the hallmarks of takotsubo has been the absence of coronary artery plaque. in a surprising finding from 2019, a study of more than 1,000 takotsubo patients undergoing coronary angiography reported that approximately 1/3 of patients had clinically significant plaque in their coronary arteries; 1/3 had evidence of sub-clinical atherosclerosis; and 1/3 had "clean coronaries," with no observable plaque. hence, much needs to be learned about this syndrome that may affect as many as 5% of women who have been diagnosed with acute mi. takotsubo is typically an emotionally challenging and life altering event. strategies for primary and secondary prevention of coronary artery disease will be discussed in the virtual group sessions. currently, there is no specialized intervention for patients diagnosed with takotsubo syndrome at weill cornell medical center, either in hospital or after discharge.

Eligibility criteria:
inclusion criteria: - all patients with documented diagnosis of takotsubo syndrome greater than 18 years old. exclusion criteria: * patients with a diagnosis of takotsubo syndrome already undergoing psychotherapy or those who choose not to participate. * vulnerable populations such as prisoners, non-english speaking subjects, pregnant women, and subjects unable to provide written informed consent will not be included in this research.

Keywords: takotsubo cardiomyopathy takotsubo syndrome
cerebral microembolism in the critically ill with acute kidney injury

Conditions: Cerebral Embolism

Summary: the primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill patients with dialysis-dependent acute kidney injury.


Eligibility criteria:
inclusion criteria: * \> 18 yrs. * signed ic exclusion criteria: * heart disease (pfo, asd, vsd, severe valvular disease) * atrial fibrillation * cerebrovascular pathology * missing temporal bone window * allergy to plastic contained in the investigative device (transcranial doppler) * chronic kidney disease * pregnancy * participation in another study
effectiveness and safety of mitral valve repair with the neochord ds1000 artificial chordae delivery system versus conventional surgery in patients with severe primary mitral regurgitation due to isolated leaflet prolapse

Conditions: Cardiovascular Diseases

Summary: the main objective is to assess the effectiveness and safety of the neochord ds1000 repair technique as compared with conventional open-heart on-pump mitral valve surgery in patients with severe primary mitral regurgitation.


Eligibility criteria:
inclusion criteria: * severe primary mitral regurgitation (grade 3+ or 4+) * class i indication for mv surgery according to esc/eacts and aha/acc guidelines: 1. symptomatic patients and/or 2. lv (left ventricular) dysfunction : lvesd ≥45 mm and/or 30≤ lvef ≤60% * leaflet prolapse of p2 and/or a2 * predicted coaptation length \> 4 mm * candidates for surgical mitral valve repair according to heart team * patient able to sign an informed consent form * patient benefiting from a social insurance system or a similar system exclusion criteria: * asymptomatic patients with preserved lv function * complex mechanism of mr (leaflet perforation, severe calcifications, commissural extension, etc) * secondary mr * predicted post-repair coaptation length less than 4 mm * atrial fibrillation * inflammatory or infective valve disease * severe lv dilation (dtd \> 65 mm) * significant mitral annulus dilatation (d \> 45 mm) * surgical indication of tricuspid annulus * contraindication to tee (transesophageal echocardiographic ) or inadequate image quality * need for any other concomitant cardiac procedure * concurrent medical condition with a life expectancy of less than 24 months * patient unable to understand the purpose of the trial * patient \< 18 years old * participation to another trial that would interfere with this trial * pregnancy

Keywords: heart valve diseases heart failure heart diseases mitral valve insufficiency
validity and reliability of iciq-fluts lf in thai version and correlation with ipss

Conditions: Validity of Thai Version of the ICIQ-FLUTS LF Questionnaire; Reliability of Thai Version of the ICIQ-FLUTS LF

Summary: the investigators recruited participants, who were female with luts 50 participants for known group validity and 80 normal control females to evaluate for construct validity and test for reliability by statistical analysis.

50 females with luts will completed the iciq-fluts and ipss and then again at 2 weeks apart to test for convergent validity and test-retest validity. the normal control group 80 women will completed iciq-fluts lf for test of construct validity.

Eligibility criteria:
inclusion criteria: * age at or over 18 years old * can read and understand thai language * have lower urinary tract symptoms exclusion criteria: * those who have a diagnosis of calculi, urinary tract cancer
cognitive behavioral therapy for arthritis pain and insomnia in older adults

Conditions: Pain Dysfunction; Sleep Disturbance; Osteoarthritis

Summary: this study compares the efficacy of three group interventions for people with co-morbid osteoarthritis (oa) and insomnia to help them manage their oa symptoms. the investigators hypothesize that a combination cognitive-behavioral treatment will produce significantly greater initial and long-term improvements in oa symptoms than will the other two treatments.

this study is only for members of the group health cooperative (ghc) of puget sound who have both osteoarthritis pain and insomnia. the first part of the study involves filling out a mailed survey. based on the results of the survey some respondents will be eligible for the second part of the study. our goal in the second part is to test three different treatments for managing oa symptoms. the programs teach about things people with arthritis can do to improve the quality of their lives. all three programs deal with pain, sleep, mood and activity-but each has a slightly different focus. participants will be randomly assigned to one of the three programs. each program is made up of six weekly group sessions that last about 90-120 minutes. the programs will be co-led by licensed therapists and each will include 8-12 members. study participants will also take part in a series of visits at their homes over the next 18 months. at each visit the investigators will ask them to do a few other study activities, such as keep a 7-day diary of their sleep and fill out a survey about their arthritis pain. with their permission the investigators will also ask them to let us collect some information from their ghc medical records.

Eligibility criteria:
inclusion criteria: * age 60+ * continuously enrolled in group health one year prior to sample pull * primary care clinic at selected clinics * not in "no contact file" * diagnosis 715xx (osteoarthritis) in prior three years exclusion criteria: * not continuously enrolled in group health for at least one year * medical record information indicates a diagnosis of: 1. rheumatoid arthritis 2. obstructive sleep apnea 3. periodic leg movement disorder 4. restless leg syndrome 5. sleep-wake cycle disturbance 6. rapid eye movement (rem) behavior disorder 7. dementia or receiving cholinesterase inhibitors 8. parkinson's disease or other neurodegenerative disease known to directly impact sleep 9. cancer in the past year and receiving chemotherapy or radiation therapy in the past year 10. inpatient treatment for congestive heart failure within the previous 6 months

Keywords: arthritis group program pain insomnia pain dysfunction and sleep disturbance among older adults with osteoarthritis.