Kornimate/medical-research-clean huggingface dataset:
genetic analysis of human hypertensive end stage renal disease (h-esrd)

Conditions: Cardiovascular Diseases; Heart Diseases; Hypertension; Kidney Failure, Chronic

Summary: to identify genes causing hypertensive end-stage renal disease (h-esrd) in high risk african-american populations

background: although hypertension is a predisposing factor for end stage renal disease, the underlying hypothesis of this study was that in select african-american families genetic factors predisposed them to develop esrd in the face of hypertension. an inherited basis for h-esrd was supported by familial clustering of h-esrd among african americans that could not be explained by socioeconomic status, access to medical care, and the prevalence of diabetes and hypertension. design narrative: dna samples were collected, identified, and clinically characterized from african-american sib-pairs (and other family members with hypertensive end-stage renal disease). this aspect of the study was based on the fact that dr. freedman, the principal investigator, had already developed a unique "family history of end-stage renal disease" database independently funded by the end-stage renal disease network six. this registry served as a very large and unique collection of african-american end-stage renal disease patients. he began with a candidate gene approach for linkage to hypertensive end-stage renal disease in his patient samples using a variety of growth factor genes, genes involved in sodium transport and vascular tone, as well as human homologues of rodent genes that had, or were to be identified in the future as contributing to esrd in that organism. if this initial first pass of candidate genes failed to demonstrate linkage to hypertensive end-stage renal disease, a systematic genome-wide scan was to be performed with available simple sequence length polymorphisms (sslp) and other polymorphic markers. hypertensive end-stage renal disease is a condition of enormous clinical and economic importance and identification of associated or causative renal-failure genes would form a genetic basis for the detection of high-risk individuals and assist in development of intervention and treatment strategies to prevent this condition. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
a study to evaluate the efficacy and safety of povorcitinib (incb054707) in participants with moderate to severe hidradenitis suppurativa (hs)

Conditions: Hidradenitis Suppurativa (HS)

Summary: the purpose of this study is to evaluate the efficacy and safety of povorcitinib (incb054707) in participants with moderate to severe hidradenitis suppurativa (hs) over a 12-week placebo-controlled period, followed by a 42-week extension period.


Eligibility criteria:
inclusion criteria: * male and female participants ≥ 18 years of age. * diagnosis of moderate to severe hs ≥ 3 months prior to screening visit. * hs lesions present in ≥ 2 distinct anatomic areas, 1 of which must be at least hurley stage ii or hurley stage iii, at both the screening and baseline visits. * total abscess and inflammatory nodule (an) count ≥ 5 at both the screening and baseline visits. * history of inadequate response to an appropriate course of at least 1 conventional systemic therapy for hs (or demonstrated intolerance to, or have a contraindication to, a conventional systemic therapy for hs) * agree to not use certain topical antiseptics on the areas affected by hs lesions during the placebo-controlled period. * willingness to avoid pregnancy or fathering children. * other inclusion criteria apply. exclusion criteria: * draining tunnel count of \> 20 at screening or baseline visits. * women who are pregnant (or who are considering pregnancy) or breastfeeding. * medical history including thrombocytopenia, coagulopathy or platelet dysfunction; venous and arterial thrombosis, deep vein thrombosis, pulmonary embolism, stroke, moderate to severe heart failure, cerebrovascular accident, myocardial infarction, or other significant cardiovascular diseases; q-wave interval abnormalities; disseminated herpes zoster or dermatomal herpes zoster; disseminated herpes simplex; chronic/recurrent infections; malignancies. * evidence of infection with tb, hbv, hcv or hiv. * history of failure to jak inhibitor treatment of any inflammatory disease. * laboratory values outside of the protocol-defined ranges. * other exclusion criteria apply.

Keywords: hidradenitis suppurativa hs incb054707 povorcitinib acne inversa hidradenitis
prostate biopsy, transrectal vs. transperineal: efficacy and complications

Conditions: Prostate Cancer; PSA; Infection

Summary: this study evaluates the difference between 2 prostate biopsy methods, transrectal (through the rectal wall) and transperineal (through the skin) needle biopsy. men who are in need of prostate biopsy due to clinical suspicions of prostate cancer will be randomly assigned (1:1) to either transrectal or transperineal approach. this research study will scientifically determine if one biopsy method is better than the other in reducing complications and improving cancer detection.

there are two ways to take biopsy (tissue) samples from the prostate. the more commonly used method is trans-rectal needle biopsy of the prostate (tr-bx) with a needle inserted through a probe in the rectum to reach the prostate. tr-bx is usually performed in the office, using local anesthesia, and often using a targeted biopsy approach using mri/ultrasound fusion technique. trans-perineal biopsy (tp-bx) with a needle inserted directly through the skin to reach the prostate. typically, tp-bx is performed in the outpatient surgical setting due significant pain associated with the procedure, requiring the use anesthesia and/or sedation. tp-bx. procedure is very uncommon in the usa and is often performed using ultrasound alone (less accurate), without the benefit of mri guided targeted biopsy. now, with the availability of new devices, we are able to perform both tr-bx and tp-bx using mri/ultrasound fusion guided targeted approach, in the office setting, using local anesthesia alone. with the tr-bx, there has been increasing risk of infection related complications, sepsis and hospital admissions. the newer approach of biopsy tp-bx may cause fewer infections and may have a higher accuracy of finding cancer. using validated questionnaires such as iief-6, ipss and trus-bxq, this randomized study of tr-bx and tp-bx will address these questions: * differences in the risk of infectious complications * differences in the overall cancer detection rate and the high-grade cancer detection rate * differences in the hemorrhagic and urinary side effects * tolerability of both techniques with local anesthesia alone * difference in the results of of mri/us fusion targeted biopsy * differences in the cost of the procedures

Eligibility criteria:
inclusion criteria: * all patients who are scheduled to undergo prostate biopsy for suspected prostate cancer as part of their regular medical care * either with or without an mri exclusion criteria: * patients with no access to rectum (due to previous rectal surgery) * any abnormalities of the perineal skin (e.g. infection) * patients whose procedure requires sedation or general anesthesia

Keywords: prostate biopsy psa infection bleeding
monocyte soluble activation markers scd14 and scd163 in children with type 1 diabetes mellitus

Conditions: Type1diabetes

Summary: the study aims to compare serum levels of scd14 and scd163 in children with type 1 diabetes mellitus with healthy controls, study the distribution of monocyte subsets in children with t1dm , correlate monocyte subsets and their soluble activation markers scd14 and scd163 with parameters reflecting islet β-cell insufficiency in children with t1dm.

type 1 diabetes mellitus (t1dm) is t-cell mediated autoimmune disease in which the function of insulin-secreting pancreatic β-cells is impaired due to autoreactive immune cell-mediated destruction (insulitis). although adaptive immunity has always been the focus for scientists in studying the pathogenesis of t1dm, yet, innate immunity also plays a critical role. alterations in innate immune responses drive autoimmune pathogenesis, with involvement in the initial break in tolerance and the later failure of regulation. several studies suggest that the development of t1dm is strongly associated with different immune cells, including monocytes. specifically, an increase in the monocyte population has been shown to trigger β-cell destruction during insulitis. intermediate monocytes may serve as m2 macrophage precursors with high anti-inflammatory properties, producing il-10. however, other studies reported them to have an antigen-presenting function with a dendritic cell-like feature. upon antigen stimulation, they became the main producers of inflammatory factors, like tnf-α which has been shown to correlate with the severity of t1dm. activation of circulating monocytes to a pro-inflammatory state induces the shedding of membrane bound cd14 (mcd14) to soluble cd14. compared to other acute phase proteins, scd14 was found to be the most sensitive in t1dm. soluble cd163 is present in blood serum as a result of shedding the cd163 membrane form of activated monocyte-macrophage-lineage cells in the course of inflammation. plasma scd163 is widely used as an immunomodulator with anti-inflammatory properties. it was found to be increased in t2dm.

Eligibility criteria:
inclusion criteria: * children of any age and sex diagnosed with t1dm (according to who criteria) with a minimum duration of five years will be included. exclusion criteria: * children with other with coexisting autoimmune, chronic, and acute inflammatory diseases.
efficacy of adding lll therapy to postural correction exercises on postnatal sij pain

Conditions: Sacroiliac Joint Pain

Summary: the purpose of the study will be to to examine the effect of low level laser therapy on pain and function disability in postnatal women with sacroiliac joint pain.

women are more susceptible to sacroiliac joint pain than men because the physiological changes associated with childbearing (e.g. pregnancy associated with weight gain, exaggerated lumber lordosis, hormone-induced ligamentous laxity and the mechanical trauma associated with childbirth) may result in sacroiliac joint pathology . low level laser is effective for treatment of various musculoskeletal pain disorders. it releases local neurotransmitters such as serotonin and endorphins. additionally, the analgesic effect of lllt is thought to be related to its anti-inflammatory action. laser irradiations also relieve pain by alleviating and removing swelling and by increasing oxygenation of the tissues, thus results in reduction of the pain .

Eligibility criteria:
inclusion criteria: * post natal women suffering from sacroiliac joint pain for at least 3 months. * they should have moderate to severe pain in the sacroiliac joint region (visual analogue scale ≥ 4). * they should have positive findings in at least three of five provocation sacroiliac joint tests (i.e., patrick's sign, gaenslen test, compression test, thigh thrust test and distraction test). * their age will range from 25 to 40 years old. * their body mass index (bmi) will be ranged from 25 to 30 kg /m2. * they should not have any musculoskeletal disorders. exclusion criteria: * lumber or hip joint pathology. * acute pelvic bacterial or viral infections or tumour. * taking nonsteroidal anti-inflammatory drugs, or hormonal treatments. * having positive straight leg raising test.
effectiveness of a massage instrument compared to placebo for upper trapezius muscle pain

Conditions: Myofascial Pain Syndrome

Summary: the purpose of this study was to determine if using a specialized massage tool was more effective than a placebo treatment in relieving pain in the upper trapezius muscle along the top of the shoulder.

the purpose of the study was to determine if a statistically significant and clinically meaningful difference exits between the fascialedge tool and placebo in the treatment of latent upper trapezius trigger points.

Eligibility criteria:
inclusion criteria: * male or female * between 18-64 years of age * a latent trigger point of the upper trapezius muscle exclusion criteria: * an active trigger point of the upper trapezius muscle * rash or infection of the skin over the trigger point * neck pain * taking anticoagulant drugs * spontaneous bleeding * long term corticosteroid use

Keywords: myofascial pain syndrome trigger points, myofascial chiropractic massage musculoskeletal manipulation
sitagliptin versus glipizide in participants with type 2 diabetes mellitus and end-stage renal disease (mk-0431-073 am1)

Conditions: Diabetes Mellitus, Type 2; End-Stage Kidney Disease

Summary: the purpose of the study is to compare sitagliptin and glipizide in lowering blood sugar in participants with type-2 diabetes mellitus (t2dm) and end-stage renal disease on dialysis who do not have adequate glycemic control.


Eligibility criteria:
inclusion criteria: * participant has t2dm. * participant is on dialysis on day of signing informed consent. * participant is unlikely to conceive or uses acceptable methods of birth control: hormonal contraceptive, intrauterine device (iud), diaphragm with spermicide, contraceptive sponge, condom, or vasectomy. * participant has hemoglobin a1c ≥7% and ≤9% measured at or within 2 weeks prior to visit 4/week -2. * participant is ≥85% compliant with study medication during the single-blind placebo run-in (as determined by tablet/capsule count) and compliant with diet, exercise and other run-in treatments during the run-in period. exclusion criteria: * participant has a history of type 1 diabetes mellitus or a history of ketoacidosis. * participant is losing weight in a weight loss program and is not in the maintenance phase (defined as \<2 kg weight loss in 2 months), or intends to be involved in weight loss intervention outside that prescribed by the study. * participant has a clinically significant hematological disorder (e.g., aplastic anemia, myeloproliferative or myelodysplastic syndromes, thrombocytopenia). * participant has cirrhosis or active liver disease. * participant has been on dialysis for \< 6 months. * participant has been diagnosed with a significant cardiovascular disorder and has new or worsening signs or symptoms of congestive heart failure within 3 months of signing informed consent. * participant has severe active peripheral vascular disease. * participant has a history of malignancy ≤ 5 years prior to signing informed consent, or \> 5 years without documentation of remission/cure. * participant is under treatment for hyperthyroidism. * participant has a hypersensitivity or contraindication to glipizide.
diet composition - metabolic regulation and long-term compliance

Conditions: Obesity

Summary: this study will compare a high-protein/low-carbohydrate diet (modified paleolithic diet, mpd) with a diet high in slow carbohydrates (nordic nutrition recommendations, nnr). the diets will be compared with respect effects on weight reduction, metabolic regulation, and long-term compliance to the diet regimes. seventy-two postmenopausal overweight healthy women have been recruited and will be followed for two years. the following variables will be studied: * anthropometry * dexa * ogtt * liver fat content measured with 1h-mrs * hepatic 11β-hsd1 activity, measured with cortisone/cortisol conversion test


Eligibility criteria:
inclusion criteria: * female * postmenopausal * bmi\>28 exclusion criteria: * disease * gravidity * smoking * prescribed medication

Keywords: obesity postmenopausal diet intervention
myeloid-related protein in evaluation of acute chest pain in the emergency departement

Conditions: Myocardial Ischemia; Acute Coronary Syndrome; Myocardial Infarction; Coronary Occlusion; Coronary Thrombosis

Summary: the purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (mrp 8/14), along with established clinical markers, for early diagnosis and risk stratification in patients presenting with acute chest pain at the emergency department. study hypothesis: mrp 8/14, alone or together with other established or new biomarkers, increases the earliness, sensitivity, and specificity of diagnosing acute coronary syndromes.


Eligibility criteria:
inclusion criteria: * all patients in the emergency department of the university hospital zurich with measurement of troponin during the routine diagnostic evaluation. exclusion criteria: * refusal or inability to give informed consent.

Keywords: acute coronary syndrome myocardial infarction coronary artery disease
different insufflation flows and effects on cerebral oxygenation in laparoscopic cholecystectomy

Conditions: Pneumoperitoneum

Summary: previous studies conducted on the hemodynamic effects of pneumoperitoneum pressures created by different insufflation flows are very limited in the literature. in a current literature review, there was no study found comparing the effects of hemodynamic changes created by low and high insufflation flows and pneumoperitoneum pressure on cerebral oxygenation. the purpose of the study was to contribute to the literature by investigating the effects of pneumoperitoneum pressures created by different flows on brain oxygenation.

after the approval of the ethics committee, a total of 69 (sixty-nine) patients who would undergo elective laparoscopic cholecystectomy were planned as asa i-iii, 18-65 years old, 34 (thirty-four) patients low insufflation flow (10 lt/min) and 35 (thirty-five) patients and high insufflation flow (40 lt/min) with pneumoperitoneum pressure. the study will be conducted as a single-center observational study in trabzon ktu faculty of medicine general surgery operating room. anesthesia always be performed by the same anesthesia team, and no intervention will be made regarding the choice of the method. the data obtained will be recorded by the anesthetists other than the team who constitute the study group, and the data obtained at the end of the surgery will be interpreted by the study team. the decision for laparoscopic cholecystectomy of the patients who will be included in the study will be made by the general surgery doctor, and the patients who are scheduled to be operated on electively will be included in the study. the patients will be taken to the operating room after their written consents are obtained and preoperative evaluations are made, and routine premedication will be applied to the patients who arrive at the operating room. the patients who will be included in the study will be monitored routinely in the general surgery room (i.e. electrocardiography (ecg), non-invasive blood pressure measurement, peripheral oxygen saturation, bispectral index (bis), and additionally nirs monitoring. no interference will be made regarding the groups in which patients who will undergo general anesthesia will be in the pneumoperitoneum group formed with low insufflation flow or high insufflation flow, only non-invasive cerebral oxygenation measurements will be made with nirs monitor (invos™ 5100c cerebral/somatic oximeter, somanetics, covidien, mansfield/ usa)

Eligibility criteria:
inclusion criteria: * elective laparoscopic cholecystectomy were planned, * asa i-iii, * 18-65 years old exclusion criteria: * cerebrovascular diseases and/or intracranial pathologies and/or related neurological events, * uncontrolled diabetes * uncontrolled hypertension * coagulopathy, * cirrhosis and/or peritonitis, * asthma and/or respiratory diseases e.g. copd, * morbid obesity, * patients with severe organ failure, * emergency cases, * cases converted to laparotomic cholecystectomy.

Keywords: laparoscopic cholecystectomy near infrared spectroscopy (nirs)
assessing the symptoms of obstructive sleep apnea

Conditions: Obstructive Sleep Apnea

Summary: the purpose of this study is to investigate the correlation between health outcomes associated with the severity of obstructive sleep apnea (osa) symptomatology, the findings will guide the design of interventional studies.

obstructive sleep apnea is a condition characterised by periods of narrowing of the pharyngeal airways during sleep causing hypoxic and hypercapnic episodes with the cessation of ventilation. considering the high number of overweight and obese individuals in western society the understanding of the pathomechanisms behind osa are important. this observational study aims to investigate the correlations between the severity of obstructive sleep apnea assessed by the apnea-hypopnea index (ahi) and different health outcomes associated with the osa.

Eligibility criteria:
inclusion criteria: * body mass index ≤39 * not received any treatment for obstructive sleep apnea. * is a non-smoker * is not epileptic * epworth sleepiness scale ≥ 10. * patient's on statins or antihypertensive drugs are included as so frequent in osa. exclusion criteria: * body mass index ≥ 39. * presence of significant or unstable renal, liver or heart failure. * receiving anti-diabetic treatment. * is a smoker. * is epileptic * presence of significant or unstable psychological morbidities.

Keywords: obstructive sleep apnea correlation ahi symptoms mechanisms
hfnc treatment in covid-19 pneumonia

Conditions: Coronavirus Infection; Pneumonia, Viral; Acute Respiratory Failure

Summary: coronavirus disease 2019 related pneumonia is causing acute respiratory failure and this is the most common reason for icu admission. we have several different way for respiratory support. hfnc is one of the new technics for oxygen support. our main purpose to observe the effect of hfnc on coronavirus disease 2019 patients' icu stay and mortality.

in the first group (group h), the data of patients undergoing hfnc treatment, and in group ii (group k), the data of patients who received cot with a reservoir mask were included. in hfnc support, the current air temperature is 31-37 degrees, the flow rate is 30-60 lt / min, and the fio2 value is targeted so that saturation is 93% and above. initially, continuous treatment was applied intermittently after the partial oxygen pressure / fraction of inspired oxygen(fio2) ratio exceeded 250 and clinical well-being occurred. in patients in group k, fingertip saturation was targeted as 93% and above, and a cot was applied with a reservoir mask with a flow rate of 6-15 l / min. the flow rate was calculated using the formula of fio2 (%) = 21 + 4 \* (liters / min) in patients undergoing cot. noninvasive mechanical ventilation was applied to patients who could not be provided with adequate clinical and laboratory well-being in both groups (partial oxygen pressure / fraction of inspired oxygen ratio below 150) and invasive mechanical ventilation if this was insufficient.

Eligibility criteria:
inclusion criteria: * we include the patient with acute respiratory failure related coronavirus disease 2019 (diagnosed with polymerase chain reaction), older than 18 year and supported by high flow nasal cannulae or conventional oxygen treatment(cot). exclusion criteria: * patients with primary pulmonary disease, glasgow coma scale≤ 12 , respiratory acidosis in the first blood gases(ph≤ 7,2 - pco2≥50) will exclude.

Keywords: high flow nasal cannula (hfnc) conventional oxygen treatment (cot)