Kornimate/medical-research-clean huggingface dataset:
cognitive behavioral therapy for depression: helping clients learn new skills

Conditions: Depression

Summary: the purpose of this study is to compare two psychological treatments for major depressive disorder (mdd): cognitive-behavioral therapy (cbt) and cbt-skill enhanced (cbt-se). cbt is well-studied, research-supported treatment for depression. cbt-se is a variant of cbt that places greater focus on helping clients to developing the skills of cbt. the study will enroll 150 participants with mdd. participants will be randomized to cbt or cbt-se, with 75 participants being assigned to each condition. for both conditions, treatment will be provided over 12 weeks, with a 6 month follow-up period. potential participants are asked to complete an initial screening and an intake evaluation to determine eligibility. after entering the study, participants are asked to complete evaluations at 4 weeks and at 12 weeks. they are also asked to respond to self-report instruments before and after each session. following the 12 week treatment, participants are asked to complete monthly follow-up surveys for 6 months. the primary objectives of this study are three-fold. the first is to compare the outcomes of the two treatments. the second is to evaluate potential mediators of any treatment differences. the third is to evaluate the process of change in these two versions of cbt.


Eligibility criteria:
inclusion criteria: 1. diagnosis of major depressive disorder (mdd) according to dsm-5 criteria; 2. 18 years old or older; 3. residence in the state of ohio; 4. access to a reliable internet connection (to participate in virtual sessions); and 5. being able and willing to give informed consent. exclusion criteria: 1. current or past diagnosis of bipolar disorder or a psychotic disorder; 2. moderate or severe substance use in the past 6 months (where "moderate" is defined as 4-5 symptoms and "severe" is defined as 6 + symptoms of those listed in dsm-5 for each of the substance-related disorders); 3. current disorder other than mdd if it constitutes the predominant aspect of the clinical presentation and if it requires treatment other than that being offered; 4. currently participating in a treatment for an emotional disorder, including any individual psychotherapy or psychiatric medications used to treat a mood or anxiety disorders; 5. clear indication of secondary gain (e.g., court-ordered treatment); and 6. current suicide risk or significant intentional self-harm in the last six months sufficient to preclude treatment on an outpatient basis.

Keywords: cognitive behavioral therapy depression randomized clinical trial cognitive behavioral skills
popular: post-operative pulmonary complications after use of muscle relaxants in europe

Conditions: Surgical Procedures, Operative; Anaesthesia

Summary: international multicenter observational study of a random-sample cohort of patients undergoing any in-hospital surgical procedure under general or regional anaesthesia during a continued 14-day period of recruitment. primary hypothesis of this study is that the use of muscle relaxants, their reversal agents, or neuromuscular monitoring increases the incidence of postoperative pulmonary complications. the secondary hypothesis is that the use of muscle relaxants increases in-hospital mortality.

overall postoperative mortality for patients undergoing non-cardiac surgery in europe is 4% (eusos study). postoperative pulmonary complications are a major factor, which increase patient morbidity and mortality (periscope study). this study is designed to evaluate the effects of management of neuromuscular blockade on postoperative pulmonary complications in a general unrestricted anaesthetized population across europe. the investigation will be a continuation of the european eusos and periscope studies. based on a well-recognised body of surrogate data, it is hypothesized that incorrect approaches to the use, monitoring, and reversal of muscle relaxants will increase the incidence of in-hospital postoperative pulmonary complications and prolong hospital stay. the investigators will not modify a participating centre's customary management of patients. patients with postoperative pulmonary complications will be identified by postoperative assessment and consulting medical records for events that fulfil the definition of postoperative pulmonary complications.

Eligibility criteria:
inclusion criteria: * adult patients undergoing any in-hospital surgical procedure under general or regional anaesthesia during the defined continued 14-day period of recruitment. exclusion criteria: 1. patients less than 18 years of age 2. patients scheduled for local or regional anaesthesia only 3. patient's anaesthetic procedure scheduled outside an operating room 4. ambulatory patients = patient planned to be discharged within 12 hours post anaesthesia 5. patient with preoperatively intubated trachea 6. patient from an intensive care unit (icu) 7. patient scheduled for additional surgical / anaesthetic procedure in the next 7 days 8. patients who had a surgical / anaesthetic procedure within the past 7 days 9. patient born outside the predetermined 'month(s)' allocated for the specific study centre.

Keywords: anaesthesia anaesthesiology muscle relaxants popular postoperative pulmonary complications respiratory failure suspected pulmonary infection pulmonary infiltrates pleural effusion atelectasis pneumothorax bronchospasm aspiration pneumonitis cardiopulmonary oedema european society of anaesthesiology neuromuscular blockade europe
obesity awareness, physical activity level and sedentary behavior in obese women

Conditions: Obesity

Summary: it is known that the incidence of obesity, which is a global health problem, is higher in women. the aim of this study is to examine the relationship of obesity awareness with physical activity level and sedentary behavior in obese women.

obese people are at risk for medical conditions that can lead to greater morbidity and mortality. it is known that the incidence of obesity, which is a global health problem, is higher in women. lack of physical activity and sedentary behavior are well-known risk factors for obesity and the relationship between them has been supported by many studies. as a matter of fact, some studies have reported that public health programs should focus on increasing individuals' physical activity levels as well as reducing sitting time. while examining the sedentary behavior and physical activity levels of obese women, evaluating their obesity awareness status, can facilitate increasing their awareness of the disease, initiating and complying with treatment. the aim of this study is to examine the relationship of obesity awareness with physical activity level and sedentary behavior in obese women.

Eligibility criteria:
inclusion criteria: * the women who are ages between 18-65 years, * bmi ≥ 30.0 kg/m2 according to who classification. exclusion criteria: * bmi \< 30.0 kg/m2 according to who classification, * male participants, * inability to cooperate with assessments, * those who have had severe trauma or surgery that limit physical activities in the last 6 months, * those who have orthopedic, neurological, cardiovascular problems that limit / prevent ambulation, * pregnancy or suspected pregnancy, * individuals are included in a rehabilitation program.

Keywords: obesity women physical activity sedantary
aortic abdominal aneurysm pilot screening programme

Conditions: Aortic Aneurysm, Abdominal

Summary: populational abdominal aortic aneurysm (aaa) pilot screening programme performed by duplex ultrasonography in population born in 1952 in health areas depending from hospital de la santa creu i sant pau in barcelona. descriptive data analysis and cost-effectiveness study will be performed.

populational abdominal aortic aneurysm (aaa) pilot screening programme performed by duplex ultrasonography in population born in 1952 in areas depending from hospital de la santa creu i sant pau in barcelona. ultrasonography evaluations will be performed in primary health centers by previously trained doctors according to study protocol and aaa management will be according to united kingdom's national health service screening model. a descriptive analysis will be performed to estimate local population prevalence of aaa in both men and women in order to create the basis for a future state aaa screening programme. a cost-effectiveness analysis will be performed in order to assess optimal screening strategies in our population.

Eligibility criteria:
inclusion criteria: * all men in our area's population census and an aleatory sample of women born in 1952 living in hospital de la santa creu i sant pau area. exclusion criteria: * previously detected or operated aaa * fragile patients not eligible for aaa repair if needed * dead people when contacted * eligible people refusing to participate * eligible people failed to be contacted twice by our department
attention training and cognitive therapy

Conditions: Social Phobia

Summary: the present study aimed to investigate the efficacy and process of change that occurs in attention training in comparison to an established treatment for social phobia, cognitive therapy. a randomized trial was conducted in which participants were allocated to either six weeks of attention training or cognitive therapy. it was hypothesized that both treatments would be effective in reducing social phobia symptoms, but that attention training would work primarily by reducing levels of self focused attention, while cognitive therapy would work through changes to probability and threat appraisals.


Eligibility criteria:
inclusion criteria: * 18 years of age, * be fluent in english * have a primary concern of social anxiety that met dsm-iv criteria (apa, 2000) for social phobia. both subtypes of social phobia, specific and generalized, were accepted into the study. exclusion criteria: * the presence of comorbid condition(s) that were more severe than the presenting social phobia
a clinical trial of retinal gene therapy for x-linked retinitis pigmentosa using biib112

Conditions: X-Linked Retinitis Pigmentosa

Summary: the objective of the study is to evaluate the safety, tolerability and efficacy of a single sub-retinal injection of biib112 in participants with x-linked retinitis pigmentosa (xlrp).

this study was previously posted by nightstarx ltd. in october 2020, sponsorship of the trial was transferred to biogen.

Eligibility criteria:
key inclusion criteria: part 1: * participants with genetically confirmed diagnosis of xlrp (with rpgr mutation). * participant with active disease clinically visible within the macular region in both eyes. part 2: - participant with mean total retinal sensitivity in the study eye as assessed by microperimetry ≥ 0.1 db and ≤8 db. key exclusion criteria: parts 1 and 2: * participant with history of amblyopia in either eye. * participated in a gene therapy trial previously or a clinical trial with an investigational drug in the past 12 weeks or received a gene/cell-based therapy at any time previously. note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: xlrp ophthalmology gene therapy retinitis pigmentosa gtpase regulator (rpgr) aav8
the effect of su-jok therapy applied in the first stage of labor on pain level in primiparas

Conditions: Labor Pain

Summary: the aim of this study is to examine the effect of sujok therapy applied in the first stage of labor on the pain level in primiparas.

birth pain, known as acute pain, is felt in the human body as one of the oldest, complex, severe and most difficult to control types of pain. however, this pain differs from other types of pain due to the fact that it reunites the mother with her baby and covers a limited period of time. pain is a subjective phenomenon that every individual experiences throughout their lives and to which people react differently. su jok therapy, an alternative and complementary therapy technique, is seen as a method that balances the energy flow based on the philosophy of non-pharmacological and non-invasive acupuncture that can be used to control labor pain. su-jok application is the development of a massage therapy that will create a feeling of comfort in the body by using certain points. there are tiny swellings on the reflection points on the hands and feet (such as the area between the 3rd and 4th fingers reflecting the uterus area). these are also called micro acupuncture points. when pressure is applied to these swellings on the hands and feet for 1-2 minutes, pain and a feeling of pulling occur. thus, the area to be massaged is determined. during the detection phase, a blunt-tipped diagnostic probe or a round-tipped stick can be used. at this stage, the same amount of pressure should be applied to the area to be applied. when a point is determined, the correct point for massage application should be massaged and energy flow should be provided. since it does not have any side effects, it is a therapy that can be used in pregnant women and is a massage application that does not require any invasive intervention.

Eligibility criteria:
inclusion criteria: * being primiparous * the pregnant woman must be over 18 years of age * to participate in the research voluntarily * the beginning of labor (water breaking, presence of non-stress testa contractions, engagement) exclusion criteria: * pregnancies outside 37-41 weeks * multiparas * those who are not pregnant * having visual, mental and auditory disabilities * being pregnant as an adolescent * not accepting participation in the research

Keywords: su jok therapy labor pain primiparous
pp13 and doppler study to predict preeclampsia

Conditions: Preeclampsia

Summary: assessment of biochemical and sonographic marker to predict the risk for developing preeclampsia among biochemical markers are serum level of placental protein 13 (pp13) and placenta growth factor (pigf). for sonographic marker doppler pulsatility index of the blood flow through the uterine maternal arteries is assessed. pp13 is produced by the placenta and released to the maternal blood circulation. it has been shown to be an effective serum marker for early onset preeclampsia (nicolaides kh et al., 2005). the purpose of this study is to combined the assessment of the biochemical markers with doppler in the first and the second trimester to provide a comprehensive evaluation of various methods for sequential and combined analysis to assess the risk for developing preeclampsia.

this is a prospective observational study enrolling all comers who attend the prenatal clinic for first trimester assessment of the risk for down syndrome. all women are providing medical and obstetric history, demography and blood samples along with doppler pulsatility index during the first and the second trimester at ga 10-13 weeks and 21-23 weeks. when possible - blood will be drawn at hospital admission for delivery. measurements of sonography and serum markers are done blinded to pregnancy outcome. patients will be assigned to three groups: 1. all comers attending the prenatal testing at ga 10-13. 2. patients with a history of at least 2 pregnancy loss or preterm delivery and treated with low molecular weight heparin at 40-80 mg/day from admission to until 12 weeks after delivery. 3. patients who admitted the emergency obgyn clinic for bleeding during the first trimester and are treated with progesterone.

Eligibility criteria:
inclusion criteria: * women age 16-45 with viable pregnancy as defined by crl and after signing on an informed consent * in group 1 all patients meeting the above are eligible when ga is below 14 weeks * in grop 2 all patients exclusion criteria: * gestation age at enrolment \> 13 weeks and 6 days by lmp verified by ultrasound at blood taking * mental retardation or other mental disorders that impose doubts regarding the patient's true willingness to participate in the study

Keywords: preeclampsia iugr gh pp13 doppler placenta ptd preterm delivery
trial using 125i embedded stent in patients with advanced esophageal cancer

Conditions: Esophageal Cancer

Summary: more than half of patients with esophageal cancer are inoperable because of late stage cancer or metastasis and they have to undergo palliative treatments. dysphagia is the major symptom of patients with inoperable esophageal cancer. to relieve the dysphagia and improve the quality of life of such patients, stent placement has been widely accepted to be an option for palliation of the symptoms. however, recurrence of the neoplastic stricture remains a challenge after stent placement. to combine the advantages of the immediate relief of the esophageal dysphagia with the stent placement and radiation therapy with brachytherapy, a novel esophageal stent loaded with 125i seeds has been developed in the authors' institute. the preliminary clinical trial in a single institute has demonstrated better results than the conventional stent. this prospective multiple center trial is designed to further demonstrate the clinical outcomes with this irradiation, stent in patients compared to those using a conventional covered stent.

esophageal cancer ranks as the fourth leading cause of death from cancer in china and sixth worldwide. although the prognosis of surgical resection for esophageal cancer has been improved, more than 50% of such patients are inoperable and have to undergo palliative treatments because of late stage cancer or metastasis. dysphagia is the predominate symptom of patients with inoperable esophageal cancer. to relieve the dysphagia and improve the quality of life of such patients, brachytherapy has previously been utilized. recently, stent placement has been widely accepted to be an option for palliation of the symptoms due to the esophageal strictures. however, recurrence of the neoplastic stricture remains a challenge after stent placement. to combine the advantages of the immediate relief of the esophageal dysphagia with the stent placement and radiation therapy with brachytherapy, a novel esophageal stent loaded with 125i seeds has been developed in the authors' institute. the technical feasibility and safety with this new stent has been demonstrated to be adequate in a healthy rabbit model. the following preliminary clinical study in a single institute has demonstrated longer survival time, better quality of life and less restenosis of the stent than whose with the conventional stent. this prospective multiple center trial is designed to further demonstrate the clinical outcomes with this irradiation, stent in patients compared to those using a conventional covered stent.

Eligibility criteria:
inclusion criteria: * histologically confirmed primary cancer of esophagus, * must be dysphagia caused by esophageal cancer, * without esophageal fistulas, * must be an inpatient, * life expectancy is over 6 months exclusion criteria: * esophageal fistulas, * tracheal compression with symptoms, * wbc \<2000/mm3 and platelet count \<50,000/mm3, * concurrent therapies after stenting:surgery, chemotherapy,radiotherapy, traditional chinese medicine

Keywords: dysphagia esophageal cancer stent brachytherapy
the evolution of relationship between results of peripheral blood test and outcomes of in vitro fertilization

Conditions: Infertility, Female; Immune Tolerance

Summary: the purpose of this study was to assess the relationship between infertility blood test results and outcomes of pregnancy and alive birth of women who underwent with or without intravenous immunoglobulin (ivig) before in vitro fertilization.

study design (brief description) 1. inclusion criteria patients had underwent infertility blood test or treatment in lee's women hospital 2. exclusion criteria no 3. endpoint 1. values of blood test (ptt, idm, ana, lupus, protein-s) 2. embryo quality 3. results of intravenous immunoglobulin (ivig) treatment (pregnancy or not) 4. alive birth rate 4. withdraw criteria and rescue medication no 5. sample size and study duration sample size: total 500 women who underwent ivf treatments and tests from jan. 2007 to dec. 2010. study duration: from date of irb agreement to dec. 2012 6. please specify objectives of study when collecting extra specimen from participants no more need to collect extra specimen from participants in this study 7. expected endpoints of treatment no 8. others no

Eligibility criteria:
inclusion criteria: * patients had underwent both infertility blood test and ivf treatment in lee's women hospital exclusion criteria: * no
evaluation of ureteral stents in the management of stone disease

Conditions: Urinary Stones; Urinary Tract Stones

Summary: a thin tube, called a ureteral stent, is inserted into the ureter and is commonly used as treatment of urinary stone disease. stents are designed to help provide drainage of the kidney in the setting of an obstructing stone, or postoperative swelling of the ureter. though their presence is only temporary, stents are associated with a significant amount of patient discomfort and bother, which can negatively impact overall satisfaction. over the past decades, there have been refinements in stent technology and usage philosophy. smaller and softer stents are now available for use in patients, though studies evaluating the relative benefits have been conflicting. the investigators aim to evaluate the effect of stent size and composition upon outcomes after the treatment of stone disease, including patient comfort and satisfaction.


Eligibility criteria:
inclusion criteria: 1. over 18 years of age and willing and able to provide informed consent 2. patients with current urinary stone disease, undergoing any of the following procedures: * cystoscopy with stent placement * ureteroscopy with intracorporeal lithotripsy exclusion criteria: 1. patients with compromised urinary tract due to cancer (e.g. bladder tumor, ureteral obstruction from non-gu malignancy) 2. patients requiring bilateral surgical stone management procedure 3. patients with any single stone exceeding 1.5 cm 4. patients with severe concurrent disease, infection, or co-morbidity that, in the judgment of the investigator, would render the patient inappropriate for enrollment 5. any patient who is on anticholinergic medication at baseline