Kornimate/medical-research-clean huggingface dataset:
evaluation of mobiderm intimate bra in the management of breast edema related to breast cancer treatment

Conditions: Breast Cancer Surgery

Summary: the aim of this exploratory study is to assess the performance and tolerability of the mobiderm intimate bra in the management of breast edema related to breast cancer treatment.

breast cancer is the most common malignancy in women in the western world. bcs followed by radiotherapy is a safe and effective procedure to treat patients with early-stage \[verbelen h., 2021\]. but some patients are troubled by breast edema in the operated and irradiated breast. the consequences of breast edema can be : an increase in breast volume, orange peel skin, heaviness of the breast, redness of the skin, breast pain, thickening of the skin, hyperpigmented skin pores \[verbelen h., 2014\]. breast edema can also imply deterioration in patients' quality of life, physical functioning, and body image \[young-afat d. a., 2019\]. according to the literature, only a few clinical studies evaluated the value of compression medical devices in the management of breast edema. the aim of the study is to perform a prospective, exploratory, monocentric, uncontrolled clinical study to look at the performance and safety of mobiderm intimate bra in the management of breast edema related to breast cancer treatment.

Eligibility criteria:
inclusion criteria: * females aged 18 years and older. * patients who have undergone conserving surgery for breast cancer. * patients scheduled to undergo radiation treatment of the breast/chest wall within the next 12 weeks after surgery. * patients with a morphology compatible with the proposed sizes of the devices, including bust girth and cup size. * patients who have signed an informed consent form prior to any study intervention. * patients with full legal capacity and enrolled in a social security system or covered by a similar health insurance. exclusion criteria: * patients with an a cup bra size. * patients with infected or acutely inflammatory skin on the chest. * patients who require chemotherapy during the follow-up period. * pregnant women or women of childbearing age without adequate contraception or in the lactation period. * participation in other clinical trials that impact the primary endpoint. * patients with a known allergy to the investigational device components. * patients with psychiatric, psychological, or neurological disorders that are incompatible with the conduct of a clinical trial. * patients unable to be followed for 12 months. * vulnerable patients, or those subject to a judicial protection measure or unable to provide informed consent freely.

Keywords: breast cancer surgery compressive bra breast edema
a study of telegenetics versus usual care to increase access to cancer genetic services

Conditions: Breast Cancer; Ovarian Cancer; Colorectal Cancer

Summary: the goal of this research is to evaluate the relative advantage of remote counseling over usual care in community health practices without access to genetic services. we will evaluate ability of remote telemedicine, referred to going forward as telegenetic services (phone or videoconferencing), to increase uptake of genetic testing and identification of genetic carriers compared to usual care. secondly, we will evaluate the advantages of videoconferencing over telephone for delivery of remote genetic services and the short-term and longitudinal outcomes of telegenetic services in socio-demographically diverse patients in community practices.


Eligibility criteria:
inclusion criteria: 1. eligible participants will include adult men and women (aged 18 and older) who can understand and communicate in english 2. meet national comprehensive cancer network® criteria for cancer genetic testing for breast, ovarian or colorectal cancers 3. have insurance coverage for genetic testing. exclusion criteria: 1. under 18 years old - professional guidelines do not recommend genetic testing for cancer risk in minors. 2. does not speak english. 3. does not have insurance.

Keywords: meet national comprehensive cancer network® criteria for cancer genetic testing for breast, ovarian and colorectal cancers
influenza 2020/2021

Conditions: Influenza Vaccine

Summary: as part of the fight against covid-19, the uk government has announced its most comprehensive flu campaign to date (https://www.gov.uk/government/news/most-comprehensive-flu-programme-in-uk-history-will-be-rolled-out-this-winter). this should not be surpising: every year nhs hospitals experience an overwhelming number of influenza cases, and covid-19 increases this concern. as in previous years, the flu vaccine is free at the point of care for people 65 and over. new this year is that later in the season the vaccine will be made available free at the point of care for people 50 and over. however, if people refuse to take the vaccine this comprehensive program cannot benefit public health. the degree to which vaccine hesitancy is expressed varies across characteristics of the vaccine considered and the time and place it is offered, and across characteristics of the person's perceptions of complacency, convenience, confidence, calculations, and communal responsibility, i.e. the "5cs". information campaigns can be used to influence all 5cs, and public facing information is often a necessary component of public health campaigns that may also include structural components. largely, information campaigns can be viewed as a type of educational intervention. educational interventions may fall short of what is needed to alter people's intentions to vaccinate where they focus on system 1 rational thinking processes and neglect system 2 automatic thinking processes. to be more effective, public health messages must be tailored to align with the "beliefs, attitudes, and motivations" of the very people they intend to influence. fact-led educational interventions to increase parents' intentions to vaccinate their children are particularly ineffective where more subtle content opposes the recipient's deep-seated values. in a different context, recycling behaviour, previous research demonstrated that messages aligned with people's deep-seated values (i.e. the moral foundations that underlie political ideologies) are more likely to promote desired behavioural intentions than unaligned messages. the present research expands the scope of previous research in two ways. first, rather than investigating parental attitudes towards vaccination, the investigators will look at people's intentions to self-vaccinate. second, the investigators will explore the effectiveness of messages aligned with the moral foundations that underlie individual's political ideologies on their intentions to be vaccinated.


Eligibility criteria:
inclusion criteria: * resident in england * age 50+ years old, inclusive the age criteria is set at 50+ years old, because this is the age group currently being advised by public health england to seek the flu jab as soon as possible this season. (https://www.gov.uk/government/news/most-comprehensive-flu-programme-in-uk-history-will-be-rolled-out-this-winter). exclusion criteria: * not a resident in england * age less than 50 years old
pronto: obstetric and neonatal emergency training program: a cluster-randomized trial to measure impact

Conditions: Pregnancy Related Complications

Summary: rates and causes of maternal mortality in mexico have dropped only slightly; thus, reaching the internationally established millennium development milestones (mdm) is still a distant goal. a fundamental part of reducing maternal and infant mortality is ensuring an adequate and timely response to obstetric emergencies. pronto2: obstetric and neonatal emergency training program is an innovative training strategy based on simulations designed to train hospital personnel to respond to obstetric emergencies. the objective of this study is to implement pronto2 in selected hospitals to measure the effectiveness of the intervention in influencing key behaviors in hospital practices, as well as measuring maternal and neonatal outcomes in intervention versus control hospitals.


Eligibility criteria:
inclusion criteria: * hospitals must be located in guerrero, chiapas, or mexico states * number of deliveries and cesareans was between 500 and 3000 in 2009 exclusion criteria: * inaccessible by car

Keywords: women maternal morbidity maternal mortality perinatal mortality perinatal morbidity training obstetric emergency medical team simulation
effect of pharyngeal inhibition by rtms on swallowing function

Conditions: Oropharyngeal Dysphagia

Summary: the aim of this study is to test the hypothesis that rtms on the dominant swallowing hemisphere is able to modify swallowing coordination.

the aim of the study is to demonstrate that rtms (on the dominant hemisphere, on the nondominant hemisphere and placebo rtms) are able to modify swallowing coordination on healthy subjects. swallowing function will be studied before and after rtms with videomanometry.

Eligibility criteria:
inclusion criteria: * 18-50 years old * healthy subjects exclusion criteria: * epilepsia * brain injury * stroke * pregnancy

Keywords: neuromodulation swallowing magnetic stimulation healthy subjects
monocyte distribution width (mdw): an early marker of sepsis in patients with comorbidities

Conditions: Sepsis

Summary: in patients with the aforementioned comorbidities, septic conditions are common and associated with high mortality rates. early diagnosis, along with prompt and appropriate management, has become a major challenge for emergency departments. however, it is often difficult to determine whether sepsis is the primary factor behind clinical decompensation, especially in patients with complex comorbidities where symptoms may be nonspecific and overlap with other causes of deterioration. this diagnostic uncertainty complicates the timely initiation of targeted treatment, making the role of biomarkers even more crucial. the measurement of sepsis biomarkers is widely used in clinical practice to enhance diagnostic accuracy, but there remains a need for a more reliable biomarker. a biomarker with higher sensitivity and negative predictive value (npv) is essential for the early initiation of treatment. several european and american studies have demonstrated the added value of mdw as an early predictor of sepsis in patients admitted to intensive care units, as well as its diagnostic performance when combined with the qsofa score. in the literature, the mdw threshold is established at 21.5, offering optimal diagnostic power with good sensitivity and specificity, supporting its clinical application and its approval by the united states food and drug administration (fda) and the european conformity (ce). in tunisia, few studies have focused on the effectiveness of this non-invasive tool in septic patients in emergency settings and its reliability in this context, highlighting the relevance of our research.

we will test the effectiveness of mdw in the early diagnosis of sepsis as a factor of decompensation in patients with comorbidities: renal failure, heart failure, and copd.

Eligibility criteria:
inclusion criteria: * patients aged over 18 years admitted to the emergency department for decompensation of congestive heart failure or renal failure, or exacerbation of copd. exclusion criteria: * patients who received antibiotic treatment in the past 7 days, pregnant women, children, non-consenting patients, patients with a history of malignant hematologic disease, polytransfused patients or those who recently received a transfusion, and patients whose mdw was not reported due to ineffective monocyte counting.
epidemiology of abnormal vaginal discharge during pregnancy

Conditions: Vaginal Infection

Summary: vaginitis among women of childbearing age is well acknowledged as a public health concern due to its high occurrence. vulvovaginitis is a disorder of the vulva and/or vagina caused by infection, inflammation, or changes in the flora. there are many types of infections that affect the vagina, the most common three types of infection: bacterial vaginosis, trichomoniasis, and candidiasis. bacterial vaginosis is the most common vaginal infection in women of reproductive age causing thin and milky vaginal discharge with a fishy odor. trichomoniasis causes a frothy, greenish-yellow discharge with a foul smell. vaginal candidiasis is one of the most common fungal infections of the female genital tract and the second most common vaginal infection affecting women of reproductive age (after the bacterial infection worldwide. it affects more than 75% of women at least once in their lifetime, with approximately 50% of them also suffering a single recurrence. about 75% of patients suffering from candidiasis are asymptomatic, but it may be symptomatic with clinical picture characterized by itching, vaginal pain, vulvar burning sensation, dyspareunia, dysuria and mildly unpleasant odor, erythema and vulvar edema, white-yellowish plaques on the walls of the vagina and cervix and cheesy vaginal discharge. the risk of vulvo-vaginal candidiasis increases by 30% during pregnancy also in pregnancy, the presence of vaginitis is related to abortion, intrauterine infection, fetal growth retardation, premature rupture of membranes, preterm birth, low birth weight, puerperal infection, and other adverse pregnancy outcomes.


Eligibility criteria:
inclusion criteria: * at any gestational age * age of patient: 19-40 exclusion criteria: * women in labor * women with current vaginal bleeding * women with current preterm rupture of membrane * women immunocompromised women * women patients who refused to participate in the study
intraoperative hyperglycemia and infections after orthopedic surgery

Conditions: Severe Hyperglycemia; Postoperative Infection; Orthopedic Patients

Summary: postoperative infections are a common complication. a relationship between perioperative severe hyperglycemia and postoperative infections has been found in patients undergoing craniotomy. the aim of this study is to evaluate the epidemiology of intraoperative severe hyperglycemia (bgc \>180 mg/dl; 10 mmol/l) and postoperative infections (wound, urinary and prosthetic joint infection) and to investigate if severe intraoperative hyperglycemia is associated with an higher risk of early postoperative (within the 7th postoperative days) infections (wound, urinary and prosthetic joint infection).


Eligibility criteria:
inclusion criteria: * orthopedic patients exclusion criteria: * non-orthopedic patients
corporeal compression at the onset of severe sepsis and septic shock

Conditions: Severe Sepsis or Septic Shock; Fluid Resuscitation

Summary: early and adequate fluid resuscitation (\< 6 hours) in patients with circulatory failure is essential but may exacerbate oedema, which may itself: 1) aggravate pulmonary lesions and prolong mechanical ventilation, 2) aggravate organ failure and 3) increase mortality notably in patients with acute renal failure. improving fluid balance is considered crucial in the management of patients in septic shock, but the efficacy of the measures currently proposed (diuretics associated or not with albumin and/or dialysis) is controversial. the investigators hypothesize that a whole-body compression using a body bandage could reduce capillary leakage and thus lead to faster restoration of a normal transmural pressure gradient in postcapillary venules and improve venous return. this is the first study to evaluate mechanical compression using a body bandage to reduce oedema in septic shock. to do this, a whole-body compression will be set up within the 12 hours following admission. water balance will be monitored daily throughout the duration of the compression and vital status of patients will be search at 7 days, 28 days and 90 days.


Eligibility criteria:
inclusion criteria: * written informed consent from a person of trust, * patients aged 18 years or over, * admitted to a medical icu for less than 24 hours, * for severe sepsis or septic shock and requiring fluid resuscitation because of hypotension and/or persistent signs of circulatory shock, * on mechanical ventilation with orotracheal intubation, exclusion criteria: * person not covered by national health insurance * recent abdominal or pelvic surgery, * contra-indication for a body bandage (pad, compartment syndrome, acute rhabdomyolysis, wounds), * pregnant women, * patients with severe sepsis or septic shock for more than 24 hours, * patients who are moribund or in whom death is probably imminent (within 24h), * patients who have given instructions not to be resuscitated, * patients under ward of court.
does chemotherapy train the mutation of the pig-a gene? (piga)

Conditions: Breast Cancer Female

Summary: the pig-a gene (in humans)/pig-a (in rodents) may be a useful reporter of acquired gene mutation. a simple and reproductive test based on flow cytometry allows detection of pig-a mutants in a few minutes with low blood volumes. many studies in rodents showed that detecting pig-a mutations is useful for identifying genotoxic exposure, but studies are needed in humans to validate this biological marker. the investigators propose to carry out a study to assess the prevalence of pig-a mutated reticulocytes among 30 patients exposed to genotoxic chemotherapy for breast cancer treatment. the investigators will prospectively collect, for each patient, 4 blood samples of 10ml during chemotherapy: the first one (t0) before chemotherapy (before genotoxic exposure), t1 during treatment (after the third cure), t2 (just at the end of chemotherapy) and t3 (five weeks after the end of chemotherapy). pig-a mutated cells frequency distributions will be compared between t0, t1, t2 and t3. at the same time, the investigators will document the impact of such a genotoxic exposure using the micronuclei test on in vitro binucleate lymphocytes. the micronuclei test reveals structural or numerical chromosome aberrations caused by aneugenic or clastogenic exposure. this test will be done on t0 and t3 blood samples of each patient.


Eligibility criteria:
inclusion criteria: * major patients * patients with breast cancer * who have benefited from breast surgical treatment and have a poly-chemotherapy adjuvanted by fec100 and docetaxel. * patients should be able to read and understand french. exclusion criteria: * minor patients * pregnant women * patients who do not speak french and/or are unable to read and understand french. * patients who have had a history of radiotherapy, including those who have received a per-operative radiation therapy as part of the initial management of breast cancer * patients who have had a history of chemotherapy outside of the chemotherapy possibly received in the treatment of current breast cancer.
acupuncture for post-stroke shoulder-hand syndrome

Conditions: Shoulder-hand Syndrome

Summary: shoulder-hand syndrome，a common complication of stroke patient，which is an important factor of limb function recovery.this research aims to observe the effect and safety of acupuncture and traditional chinese medicine combined with rehabilitation therapy for post-stroke shoulder-hand syndrome.furthermore, the investigators will promote the treatment in community hospital.


Eligibility criteria:
inclusion criteria: - ischemic stroke and shoulder hand syndrome,conscious,for 2 weeks to 6 months,patients with i or ⅱ period. exclusion criteria: - disturbance of consciousness,with shoulder joint disease or muscle disease,patients with shoulder hand syndrome ⅲ period,serious primary diseases such as heart,liver and kidney,mental illness.

Keywords: acupuncture，rehabilitation,shoulder-hand syndrome
exercise as alcohol use disorders intervention for non-treatment seeking adults

Conditions: Alcohol-Related Disorders

Summary: alcohol use disorders are common and few individuals with the disorder ever seek help. this study proposes to intervene in a novel way - exercise, as it has many mental and physical health benefits and is an activity that is incompatible with simultaneous alcohol use. if effective, this non-stigmatizing intervention may increase the utility and acceptability of interventions for alcohol use disorders and ultimately increase the number of individuals effectively treated.

about 26 million americans (8.5%) meet criteria for an alcohol use disorder (aud; i.e., abuse or dependence), and most with an aud will not ever seek help. a variety of reasons exist for not seeking help, with stigma and desire to handle the problem on one's own being primary among them. therefore, offering interventions for aud that do not stigmatize or require an individual to see a mental health professional may increase the utility and acceptability of aud interventions and ultimately increase the number of individuals effectively treated. this pilot study evaluates exercise as an aud intervention. exercise has been proposed as a potential treatment for aud due to its numerous mental and physical health benefits. thirty sedentary non-treatment seeking aud individuals to be recruited from the community via advertisements. participants will be given a four month ymca gym membership and will be randomized to one of two conditions: (1) assessment only (ao), or (2) a combination of two motivational enhancement therapy (met) sessions focused on increasing exercise spaced two months apart and four months of weekly contingency management (cm) for adhering to specific exercise activities. met is a client-centered, directive method of enhancing intrinsic motivation to change by exploring and resolving ambivalence, and cm is a behavioral treatment offering individuals tangible reinforcers such as prizes for completion of specific target behaviors. assessments of all participants will take place at baseline, 2-months (mid-treatment), and 4-months (post-treatment. results from this pilot study will guide future investigations of exercise as a method for intervening with non-treatment seeking aud individuals.

Eligibility criteria:
inclusion criteria: * age 21-55 years * english speaking * sedentary * alcohol-related problems * recent heavy drinking episodes * blood pressure \<165/95 mmhg exclusion criteria: * currently receiving or desiring treatment for alcohol problems * contraindications for exercise * acute psychiatric problems that require immediate treatment * obese - class ii * pregnant or desire to become so in the next several months * other substance dependence * in recovery for pathological gambling
long-term study of paroxetine in women and men

Conditions: Social Phobia

Summary: this study is designed to evaluate the efficacy and safety in social anxiety disorder (sad)


Eligibility criteria:
inclusion criteria: * diagnosis of social anxiety disorder (sad) (300.23 social phobia/social anxiety disorder) according to dsm-iv-tr criteria. * must give a written informed consent. * if the patient is under 20, both the patient himself/herself and his/her proxy consenter must give written informed consent. * patients have a minimum score of 60 on the lsas total score. exclusion criteria: * patients primarily diagnosed with a disorder that is categorized into axis i excluding sad by dsm-iv-tr (e.g. major depression, dysthymic disorder, specific phobia (simple phobia) , obsessive compulsive disorder, panic disorder) within 24 weeks before week -2. * patients with a history or complication of schizophrenia and bipolar disorder * patients with a complication of body dysmorphic disorder. * patients with evidence of substance abuse (alcohol or drugs). * substance dependence by dsm-iv-tr criteria within 24 weeks before week -2. * patients who started psychotherapy and cognitive-behavioural therapy within 24 weeks before week-2, except for supportive psychotherapy. * patients receiving electro-convulsive therapy (ect) within 12 weeks before week -2. * patients being pregnant, lactating or are of childbearing potential and are likely to become pregnant. * patients with 3 or more points of ham-d item no. 3, or who are likely to attempt suicide. * patients with a history or complication of cancer or malignant tumor. * patients receiving mao inhibitors (fp®) within 14 days before expected week 0 visit date.

Keywords: social (sad) anxiety disorder