Kornimate/medical-research-clean huggingface dataset:
epi-743 for mitochondrial respiratory chain diseases

Conditions: Mitochondrial Diseases

Summary: this study will evaluate the safety and efficacy of epi-743 in participants with severe mitochondrial respiratory chain diseases who are considered to be within 90 days of end-of-life care.


Eligibility criteria:
inclusion criteria: 1. participants with genetic diagnosis: genetically confirmed diagnosis of inherited mitochondrial respiratory chain disease 2. participants with clinical diagnosis: diagnosis of inherited mitochondrial disease absent genetic confirmation; specifically, participants must meet the diagnostic criteria of "definite" or "probable" mitochondrial disease as defined by bernier et al., 2002 3. deemed by principal investigator to be within 90 days of end-of-life hospice/terminal care 4. male or female age \> one year 5. hematocrit within normal range for age group 6. agreement to use contraception if within reproductive years 7. participant or participant's guardian able to consent and comply with protocol requirements 8. presence of caregiver to ensure study compliance 9. abstention from use of all pill-form dietary supplements and non-prescribed medications (except as allowed by the investigator) 10. abstention from foods or beverages or bars fortified with coenzyme q10, vitamin e, super-fortified "functional" foods or beverages 11. abstention from use of idebenone 12. clinically staged with a mitochondrial disease scale such as the newcastle score exclusion criteria: 1. allergy to epi-743, vitamin e or sesame oil 2. clinical history of bleeding or abnormal prothrombin time (pt)/partial thromboplastin time (ptt) (excluding anticoagulation rx) 3. hepatic insufficiency with liver function tests (lfts) greater than two times normal 4. renal insufficiency requiring dialysis 5. fat malabsorption syndromes precluding drug absorption 6. any other concurrent inborn errors of metabolism 7. severe end-organ hypo-perfusion syndrome secondary to cardiac failure resulting in lactic acidosis 8. pregnancy

Keywords: leigh syndrome melas kearns-sayre alper's inherited mitochondrial disease friedreich's ataxia polg1 deficiency
gastrointestinal activation post-elective cs (cesarean section) :a comparison of paula method to standard care

Conditions: Bowel Dysfunction

Summary: women generally report discomfort and a delay in gi motility after cs. the paula method, circular exercises of ring muscles has been shown to increase gi motility. this method had not been studied in women post cs. the current study is comparing the resumption of bowel sounds after cs in women utilizing the paula exercises to standard care (no exercises).


Eligibility criteria:
inclusion criteria: * elective, singleton, term cs, with spinal or epidural anesthesia exclusion criteria: * gi/ absorption disorders (chron's, ibs) * general anesthesia * urgent cs
a study of remitoro in participants with recurrent or refractory peripheral t cell lymphoma and cutaneous t cell lymphoma (all case study)

Conditions: Lymphoma, T-cell, Peripheral; Lymphoma, T-cell, Cutaneous

Summary: the primary purpose of the study is to investigate the incidence of adverse drug reactions (adrs) (adr of special interest: capillary leak syndrome, infusion reaction, rhabdomyolysis, myelosuppression, infection, hepatic dysfunction, visual impairment/color blindness, ischemic heart disease/arrhythmia/cardiac failure, and severe skin disorders).


Eligibility criteria:
inclusion criteria: 1. participants with ptcl or ctcl.

Keywords: peripheral t cell lymphoma cutaneous t cell lymphoma remitoro e7777 adverse drug reactions
the effects of mesenchymal stem cell secretome in rheumatoid arthritis patients

Conditions: Rheumatoid Arthritis

Summary: this research is a clinical trial of administering mesenchymal stem cell secretome to rheumatoid arthritis patients.

this research is experimental. the research subjects were 30 rheumatoid arthritis patients. the control group received a placebo, and the treatment group received mesenchymal stem cell secretome on the 1st, 2nd, 3rd, 4th, 5th, 6th, 7th, 14th, 21st, and 28th. the data collected were erythroblastic acidity, hscrp, interlukin 6, das-28, and assessment of drug side effects before and after therapy. statistical test with paired difference test with p\<0.05

Eligibility criteria:
inclusion criteria: * rheumatoid arthritis patients exclusion criteria: * pregnancy

Keywords: rheumatoid arthritis, messenchymal stem cell secretome
fibrin glue for perianal fistulas in crohn's disease: a randomized controlled trial

Conditions: Crohn's Disease

Summary: this multicenter, randomized, controlled trial was conducted by the groupe d'etude thérapeutique des affections inflammatoires du tube digestif (getaid) to evaluate the efficacy and safety of the injection of fibrin glue in perianal fistulas tracts of patients with cd. the institutional independent ethics committee of marseille, france and of liège, belgium approved the protocol for each participating centers. recruitment took place at 12 sites (11 in france and 1 in belgium)


Eligibility criteria:
inclusion criteria: * at least 18 years old * cd confirmed by endoscopy and histology. * cdai should be 250 or less * at least one perianal fistula (between anus or low rectum and perineum, vulva or vagina) draining for more than 2 months duration exclusion criteria: * treatment with an anti-tnf agent or with ciclosporin or tacrolimus within the last 3 months * presence of a perianal abscess (\>1cm) assessed by magnetic resonance imaging (mri) or endo-anal ultrasonography performed within the last month, * presence of anal or rectal stenosis, * surgery during the previous month (except seton removal), * previous fibrin glue injection, * pregnancy.

Keywords: patients cd complicated least one perianal fistula draining 2 months duration
disruption of circadian rhythm and healthcare-related infection in patients with severe trauma

Conditions: Infection

Summary: circadian rhythms, which play crucial roles in physiology, are emerging as important regulators of specific immune functions. hospitalization in intensive care unit leads to a deep impairment of circadian rhythm. infection is a frequent event during icu hospitalization. the investigators hypothesis is that in trauma patients the lack of circadian rhythm variations is associated with the occurrence of infection. the primary aim of the study is to assess the circadian variations of plasma bmal1 in the occurrence of healthcare related infection during the 30 days after inclusion. the secondary aims are to assess the plasma expression of circadian genes (clock, cry1, per3, and rev-erba), the production of cytokines in plasma, and the concentration of cortisol, according to the occurrence of an infection.


Eligibility criteria:
inclusion criteria: * trauma patients with an injury severity score \> 15, requiring mechanical ventilation for at least 24 h during the first 48 h and an arterial catheter. exclusion criteria: * pregnant and lactating women

Keywords: infection in icu
the long-term outcome after toric intraocular lens implantation

Conditions: Corneal Astigmatism; Cataract

Summary: corneal astigmatism is refractive error that impairs uncorrected visual acuity. when patients undergo cataract surgery, implantation of toric iol is deemed the most effective choice for correcting corneal astigmatism and reducing postoperative spectacle dependence. previous studies report that the visual effects and rotational stability of toric iols are well maintained over 1- or 2-year follow-up periods. however, the long-term changes in the effects of toric iols remain unclear.

corneal astigmatism is refractive error that impairs uncorrected visual acuity. when patients undergo cataract surgery, implantation of toric iol is deemed the most effective choice for correcting corneal astigmatism and reducing postoperative spectacle dependence. previous studies report that the visual effects and rotational stability of toric iols are well maintained over 1- or 2-year follow-up periods. however, there is a long-term against-the-rule (atr) change of corneal astigmatism with aging，which influences the long-term outcomes of refractive surgery. the long-term changes in the effects of toric iols remain unclear. this study aim to observe the clinical effect of toric iol implantation in the correction of corneal astigmatism.

Eligibility criteria:
inclusion criteria: * ≥18years old * regular astigmatism * corneal astigmatism ≥ 0.75d exclusion criteria: * macular degeneration and retinal disease, history of glaucoma, corneal disease * previous corneal or intraocular surgery, and history of ocular inflammation. * pupils can not be dilated (\< 7mm)
early chemotherapy intensification in interim-positron emission tomography (pet) positive hodgkin lymphoma

Conditions: Hodgkin Lymphoma

Summary: early interim-pet after two courses of chemotherapy is a powerful outcome predictor in advanced-stage hodgkin lymphoma (hl) patients treated with adriamycin (doxorubicin), bleomycin, vinblastine and dacarbazine (abvd). two-year progression free survival of pet-2 positive patients is only 12%, but the optimal treatment for this patient subset is still unknown. from january 2006 gitil (gruppo italiano terapie innovative nei linfomi) suggested an early intensification of chemotherapy with beacopp \[bleomycin, etoposide, adriamycin (doxorubicin), cyclophosphamide, oncovin (vincristine), procarbazine, and prednisone\](4 escalated + 4 baseline cycles) for all the hl patients with a positive pet-2 after 2 abvd courses. the investigators retrospectively recorded and analyzed these data in order to evaluate if this strategy could be of benefit for this subset of patients.


Eligibility criteria:
inclusion criteria: * patients with advanced hodgkin's lymphoma according to the world health organization classification * age 16-80 * not previously treated * stage iib to ivb or stage iia with adverse prognostic factors (more than 3 nodal sites, esr \> 50 mm, bulky lesion) * written informed consent exclusion criteria: * patients aged more than 80 * concomitant or previously treated neoplastic disorder less than 5 years before the diagnosis of hodgkin's lymphoma * psychiatric disorders * uncontrolled infectious disease * impaired cardiac (ef \< 50%) or renal (creatinine clearance \< 60 ml/m)function * pregnancy and lactation * uncompensated diabetes mellitus and fasting glucose levels over 200 mg/dl

Keywords: pet
evaluation of california's sb 19 pupil nutrition act

Conditions: Obesity

Summary: four california school districts will be randomized to early implementation of california's sb 19 pupil nutrition act or to business as usual. over 5000 4th, 5th and 7th graders will be evaluated at baseline, 4-month, and 16-month follow-up in order to determine if the sb 19 nutrition and physical activity policies have had an impact on students' risk of excess body weight. the impact of early implementation of sb 19 on academic achievement will also be assessed.

four california school districts will be randomized to early implementation of california's sb 19 pupil nutrition act or to business as usual. the nutrition provisions in sb19 include assuring that no elementary school sells carbonated beverages at any time and that no middle schools sell carbonated beverages until after the end of the lunch hour each day. the nutrition provisions also include some restrictions on the sale of high-fat, high-sugar snack foods as well as encouragement to make fruits and vegetables more available to students. the legislation further encourages school districts to invest more heavily in providing students with opportunities to be physically active. high schools are not affected by this legislation. over 5000 4th, 5th, and 7th graders from 28 schools will be evaluated at baseline, 4-month and 16-month follow-up in order to determine if the sb 19 nutrition and physical activity policies have had an impact on students' risk of excess body weight. the principal outcome measure is sex- and age-adjusted bmi percentile as determined from the cdc growthchart percentiles. other measures include waist circumference, time to complete one mile run/walk, and blood pressure. the impact of early implementation of sb 19 on academic achievement will also be assessed, using students' standardized math and language arts achievement test scores.

Eligibility criteria:
healthy 4th, 5th or 7th graders able to fill out a 30-minute questionnaire in english and able to participate in aerobic physical activity.

Keywords: obesity food policy physical fitness (respiratory burst) academic achievement
ulinastatin preventing postoperative hepatic failure in hepatocellular carcinoma (hcc)

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is to confirm that ulinastatin is a safe and effective drug and it can reduce the incidence of postoperative hepatic failure in hcc patients. to evaluate that ulinastatin can improve survival in hcc patients or not.

hepatocellular carcinoma (hcc), a serious disease with high incidence at home and abroad, still shows a rising trend. postoperative hepatic failure remains a major reason of liver resection's failure. • as broad spectrum of enzyme inhibitors, ulinastatin has the valid therapeutical effect of hepatic failure and hepatic ischemia-reperfusion injury in animal experiment. and it restrain inflammatory mediator to release. but it's lack of clinical evidence that ulinastatin reduce the incidence of postoperative hepatic failure in hcc patients the purpose of the study is to assess the effort for comparing ulinastatin's drug protection in patients with hepatocellular carcinoma (hcc) for postoperative hepatic failure and to evaluate that ulinastatin can improve survival in hcc patients or not.

Eligibility criteria:
inclusion criteria: 1. male or female patients \> 35 years and \<=55 years of age. 2. confirmed case (patients with hcc) 3. tumors can be radical removed and resection volume was 50% to 70%. 4. criteria of liver function: child a level, serum bilirubin ≤ 1.5 times the upper limit of normal value,alanine aminotransferase and aspartate aminotransferase ≤ 2 times the upper limit of normal value. 5. no dysfunction in major organs; blood routine, kidney function, cardiac function and lung function are basically normal. hbg ≥ 90g/l, wbc ≥ 3.000 cells/mm³,platelets ≥ 80.000 cells/mm³. 6. karnofsky performance score performance over 60. 7. patients who can understand this trial and have signed information consent. exclusion criteria: 1. patients who have undergone previous treatment by ulinastatin. 2. patients with apparent cardiac, pulmonary, cerebronic and renal dysfunction, which may affect the treatment of liver cancer. 3. patients with other diseases which may affect the treatment mentioned here. 4. patients with medical history of other malignant tumors. 5. subjects participating in other clinical trials. 6. extrahepatic metastasis, portal vein or other major vascular involvement. liver function: child b c. 7. patients would not sign the consent to the trial.

Keywords: hepatocellular carcinoma ulinastatin hepatic failure
predictive value of early changes of chromogranin a levels in patients with neuroendocrine tumours treated with prrt

Conditions: Early Release of Chromogranin A (CgA)

Summary: the results of the study suggest that an early change in cga levels might serve as a prognostic factor in net patients treated with prrt.


Eligibility criteria:
inclusion criteria: * confirmed net * peptide receptor radionuclide therapy (prrt) exclusion criteria: * lack of patient consent to a clinical trial
effects of high flow nasal cannula on breathing and the respiratory system parameters

Conditions: Healthy

Summary: the aim of this study is a detailed investigation of the effect of high flow nasal oxygenation (hfno) on respiratory system characteristics and ventilation parameters in healthy adult subjects and the subsequent use of measured data to answer the following questions: what level of positive end expiratory pressure (peep) causes a hfno with different flow rates? does hfno work as pressure support or does it act more like a continuous positive airway pressure (cpap) ventilation?

high flow oxygen through nasal cannula is widely used in the setting of hypoxemic respiratory failure of heterogenous etiology with very good patients compliance. however, the evidence of what level of peep or pressure support (if any) with different flow rates is weak. our goal is to determine these effects and compare them with standard approach with non-invasive ventilation via full face mask.

Eligibility criteria:
inclusion criteria: * healthy volunteers willing to participate exclusion criteria: * general contraindications for oesophageal catheter insertion: oesophageal varices, bleeding disorders (including anticoagulant medication), diverticulitis, oesophageal tumors, history of recent oesophageal/gastric surgery, recent epistaxis, * sinusitis * allergy to local anesthetics * subject refusal

Keywords: high flow oxygenation electrical impedance tomography non invasive ventilation
comparıson of sılıcone and acrylıc medıcal adhesıve tapes on skın i̇njury nasogastrıc tube

Conditions: Medical-adhesive; Skin Injury

Summary: this randomized controlled experimental study was conducted to compare the effects of silicone and acrylic medical adhesive tapes on medical-adhesive related skin injury in the fixation of nasogastric tubes in patients being monitored in intensive care.

this randomized controlled experimental study was conducted to compare the effects of silicone and acrylic medical adhesive tapes on medical-adhesive related skin injury in the fixation of nasogastric tubes in patients being monitored in intensive care. the population of the research consisted of patients with nasogastric tubes who were hospitalized in the neurology intensive care unit of ege university hospital (health practice and research center) between the dates of 01.06.2022 and 31.12.2023. the sample of the study consisted of 76 patients who were hospitalized in the neurology intensive care unit during this date range, had a nasogastric tube inserted, complied with the limitations of the study and agreed to participate in the study. patients were stratified according to their age groups and assigned to experimental and control groups by block randomisation technique. the nasogastric tube of the patients in the control group was fixed with acrylic medical adhesive tape which is used in routine practice, and the nasogastric tube of the patients in the experimental group was fixed with silicone medical adhesive tape. starting from these condday following the nasogastric tube insertion, the medical adhesive tape that enables the fixation of the nasogastric tube was removed by wetting it with a sterile tampon impregnated with distilled water, and the patient's nasal skin was observed for 10 minutes each time, during 7 days for the presence of erythema, edema, denudation, dryness, infection, and vesicles. then, the same medical adhesive tape was applied again and the tube was fixed. the data were analyzed in spss 25.0 program. mann-whitney u test, pearson chi-square test and fisher's exact probability test were used to analyze the data. the nasogastric tube of the patients in the control group was fixed with acrylic medical adhesive tape which is used in routine practice, and the nasogastric tube of the patients in the experimental group was fixed with silicone medical adhesive tape.

Eligibility criteria:
inclusion criteria: * feeding with a nasogastric tube * being between the ages of 18-85 * voluntarily participating in the study * having the first nasogastric tube inserted after admission to the intensive care unit and having the tube detected by the researcher. exclusion criteria: * having any dermatological disease * having a history of allergy * having a lesion on the skin of the nose * failure to detect the tube by the researcher when the first nasogastric tube was inserted after admission to the intensive care unit.

Keywords: nasogastric tube medical-adhesive silicone acrylic skin injury
ultrasound elasticity imaging of venous thrombi

Conditions: Thrombosis

Summary: the purpose of this study is to see if the investigators can use ultrasound imaging to determine the type of clots in patients to help better manage their care.

deep vein thrombosis (dvt) is a blood clot and is a common illness that can result in pain and death if not recognized and treated well. death can occur when the venous clots break off and form pulmonary emboli (pe), which can block the arteries of the lungs. dvt and pe most often complicate the course of sick patients but may also affect healthy persons. dvt can also be a chronic disease. in those instances in which dvt and pe develop, in addition to the death risk, hospitalization is drawn out and healthcare costs are increased. therefore, the purpose of this study is to see if we can use ultrasound imaging to determine the type of clots in patients to help better manage their care.

Eligibility criteria:
inclusion criteria: * male or female subjects who have a diagnosis of chronic dvt that is at least 2 weeks old and are free from an acute dvt on top of your chronic dvt. * male and female patients who have been diagnosed with an acute blood clot by the diagnostic vascular lab and w/symptoms occurring within the previous 2 weeks. * patients under the age of 18 who give assent (permission) and whose parents give consent. * adult patients who give consent. exclusion criteria: * none