Kornimate/medical-research-clean huggingface dataset:
a online-delivered cognitive-behavioral intervention for dysfunctional worry related to the covid-19 pandemic

Conditions: Dysfunctional Worry

Summary: the purpose of this study is to investigate if a brief online-delivered cognitive-behavioral intervention can reduce the degree of dysfunctional worry related to the covid-19 pandemic, compared to a wait-list control condition.

worries about the immediate and long-term consequences of the ongoing covid-19 pandemic are largely justified in the current climate of uncertainty. however, dysfunctional worry, that is, pervasive worry that is disproportionate in its intensity or duration, and that significantly interferes with every-day problem-solving or goal-driven behavior, is clearly counterproductive. research has also indicated that repeated media exposure to a community crisis can lead to increased anxiety and heightened stress responses, that can give a downstream effect on health, and misplaced health-protective and help-seeking behaviors which, in turn, may overburden health care facilities. there is an urgent need to develop a brief, scalable intervention to target such dysfunctional worry in the general population. the current randomized controlled trial will evaluate the feasibility and efficacy of a brief online-delivered cognitive behavioral intervention designed to target dysfunctional worry related to the covid-19 pandemic. 670 individuals are randomized to intervention or to waiting-list. the hypothesis is that the brief self-guided intervention will show significant within-group reductions in self-rated worry from baseline (week 0) to post-treatment (week 3), and that these improvements will be larger than those seen in the wait-list control group. the wait-list group will be crossed over to receive the intervention after three weeks (post-treatment). all participants will be followed-up one month and one year after the end of the intervention.

Eligibility criteria:
inclusion criteria * the following 2 criteria must be met: * worrying about covid-19 and its possible consequences (e.g. risk of getting ill, fear of death, economy, family, etc.) every day, often several times a day * the worry about covid-19 is perceived as difficult to control * in addition, at least one of the following negative consequences of worrying: * the worry about covid-19 takes so much time and energy that it is difficult to concentrate on anything else (work, family, hobbies, etc.) * trouble sleeping due to covid-19 worries * constantly checking the news and social media to follow developments about covid-19 * marked loss of work productivity due to worries about covid-19 * difficulties finding joy in everyday situations because of worry about covid-19 * ≥ 18 years of age * resident in sweden * daily access to a computer or other device with internet connection exclusion criteria * non swedish speaking * severe depression, defined as \>28 points on the madrs-s * suicidal risk defined as 5 points or above on item 9 on the madrs-s * family member in the same household who is included in the study

Keywords: covid-19 internet-delivered cognitive behavioral intervention
predicting cell death by radiation therapy in early stage non-small cell lung cancer: a prospective translational trial

Conditions: Early Stage Non-small Cell Lung Cancer

Summary: surgical resection with mediastinal lymph node sampling is currently the therapy of choice for early stage (i-ii) non-small cell lung cancer (nsclc). selected patients unwilling or unable to tolerate surgery are referred for so-called 'curative' high dose radiotherapy. this has shown to result in a long term local disease control rate and a high cancer specific survival. the current trial addresses the relationship between blood and tissue biomarkers, bio-imaging and pathology in patients with early stage nsclc treated with hypofractionated radiation therapy and surgery.


Eligibility criteria:
inclusion criteria: * proof of ct1a/b - 2a/b n0m0 nsclc * informed consent signed * resectable tumour * operable patient * \> 18 years old * men and women

Keywords: early stage non-small cell lung cancer hypofractionated radiation therapy
assessment of cftr-modulator treatment in cystic fibrosis lung disease using novel structural and functional mri

Conditions: Group 1: Healthy Controls; Group 2: Stable CF; Group 3: CF Participants Anticipated to Receive CFTR-modulator Therapy; Group 4: 4-8 yo CF Participants Starting Triple Combination Modulator Therapy

Summary: this is a prospective, longitudinal observational study conducted at the hospital for sick children (sickkids). the purpose of this study is to evaluate the ability of mri to detect changes in lung structure and function in cf patients receiving cftr-modulator therapy. participants who meet eligibility criteria and consent to the study will undergo study procedures which include spirometry and body plethysmography (optional), multiple breath washout testing, mri and measurement of quality of life. the study will consist of three to six study visits for group 1, 2 and 3: baseline, one month (±1 week) and 6 month (±2 week) and if they re-consent then 3 additional visits of 1 year (±6 months). (2 years (±6 months) and 3 years (±6 months) follow-up. some participants in group 2 may transition to group 3. this study includes three populations of interest: group 1: 25 healthy volunteers, group 2: 25 patients with stable cf lung disease , group 3: 20 patients with cf lung disease anticipated to receive treatment with cftr-modulator therapy and group 4: 18 patients with cf who are between 4-8 years old and are starting triple combination modulator therapy using the rapid lung and abdominal imaging methods.


Eligibility criteria:
inclusion criteria: * participants must be greater than or equal to 4 years of age * informed consent by patient or parent/guardian consent and participant assent when appropriate. * able to perform reproducible spirometry and achieve a breath hold duration sufficient for mri acquisition exclusion criteria: * medical instability that would preclude the ability to undergo the required investigations * fev1 % predicted \< 40% * severe claustrophobia * does not meet mri screening criteria * cough within the past 3 days prior to study visit * usage of oral antibiotics within 3 weeks prior to study visit

Keywords: cftr modulator treatment xenon mri lung
the effect of cryotherapy on breast cancer patients

Conditions: Chemotherapy-induced Peripheral Neuropathy

Summary: the goal of this clinical trial is to test the effect of cryotherpay on chemotherapy-induced peripheral neuropathy(cipn) among breast cancer patients. the main questions of research are: * does cryotherapy reduce the incidence of cipn? * does cryotherapy reduce the severity of cipn and improve the quality of life? participants will be put on the cold gloves and boots during chemotherapy injection process and total 90 minutes. if there is a comparison group: researchers will compare usual care group to make sure if it effects of cipn.

this study is designed as a experiment study. in a medical center and breast ward, a randomized controlled trial was used to evaluate the effect of cryotherapy. block sampling was adopted, and participants total 94 were included. patients were randomly assigned to the croytherapy group (n=47) or the usual care group(n=47). both hands and feet received cryotherapy, and the frequency was once every three weeks. each cycle was 90-150 minutes, and the cycle was performed 4-8 times. the instrument included eprtc qlq-cipn20, pnq, and eortc qlq-c30. after 12-32 weeks, the cryotherapy received qualitative interviews to collect experience and perceptions. quantitaitve data were constructed and analyzed with spss 20.0 version, and chi-square test was used to detect the incidence of cipn after three months. mixed linear model was used to detect the severity of peripheral neuropathy symptoms and quality of life. survival analysis was used to compare the occurrence time of peripheral neuropathy events between groups.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of breast cancer stage i-iii, first time receive paclitaxel neurotoxic chemotherapy, consciousness clear, able to communicate in taiwanese or mandarin exclusion criteria: * insulin depent diabetes, raynaud's disease, cold urticaria disease, cryoglobulinemia and sclerosing basal cell carcinoma, those diagnosed with mental illness, and those with visual or hearing impairments.

Keywords: breast cancer chemotherapy neuropathy cryotherapy
pilot clinical trial of computer-based motivational intervention - 1

Conditions: Substance-Related Disorders

Summary: pilot trial of computer-based motivational intervention. hypothesis: the brief computer-delivered intervention would result in higher motivation to change at follow-up.

participants were randomized into brief intervention vs. assessment-only conditions, with follow-up to measure overall motivation to change.

Eligibility criteria:
woman in immediate post-partum period inclusion criteria: self-report of drug use prior to pregnancy exclusion criteria: frank psychosis or other cognitive impairment; inability to communicate in english; fatigue; recent receipt of narcotic pain medication; grieving over medically compromised infant
lianhua qingke for the rehabilitation of patient with omicron infection

Conditions: Coronavirus; Traditional Chinese Medicine

Summary: the patients with omicron infection usually have fever, respiratory symptoms, tachycardia, headache, toothache, muscle soreness, physical decline, and so on, while others are asymptomatic patients. it is urgent to find drugs to improve the long-term rehabilitation of symptomatic patients with omicron infection and decrease the duration of viral shedding in both symptomatic and asymptomatic patients. this study aims to investigate the efficacy and safety of lianhua qingke tablets in patients with omicron infection. the duration of viral shedding and symptoms will be evaluated. 6-month follow-up will be performed to evaluate the effect of lianhua qingke on long-term rehabilitation of all symptoms induced by omicron infection, as well as infection events.


Eligibility criteria:
inclusion criteria: * confirmed omicron infection by virus testing; * ≥18 years of age; * informed consent provided. exclusion criteria: * overt bacterial infection in the respiratory tract resulting from common pathologies, including primary immunodeficiency disease, acquired immunodeficiency syndrome, congenital respiratory malformation, congenital heart disease, gastroesophageal reflux disease, and abnormal lung development; * asthma treated daily, chronic airway disease, respiratory bacterial infections (e.g., purulent tonsillitis), acute tracheobronchitis, sinusitis, otitis media, and further respiratory tract pathologies potentially affecting the trial's data analysis; * common pulmonary diseases (e.g., severe pulmonary interstitial lesions and bronchiectasis) confirmed by chest ct; * severe pneumonia requiring ventilator use; * previous or present diseases potentially affecting trial participation or influencing study outcome, based on the investigator's judgment; * pregnancy or lactation in women; * participation in a clinical study in the past 3 months; * history of allergy to ≥2 drugs or foods or known allergy to the drug's constituents.
a preliminary, non-comparative study to evaluate a bioresorbable wound scaffold in acute wounds

Conditions: Pilonidal Sinus

Summary: as this is a proof-of-concept study, the primary objective is to provide preliminary data on the safety and efficacy of bioresorbable wound scaffold in the management of acute wounds left to heal by secondary intent.


Eligibility criteria:
inclusion criteria: * subjects over 18 years, willing and able to provide written informed consent. * subjects who have an excised pilonidal sinus wound left to heal by secondary intent. * subjects who are willing to commit to having two biopsies being taken during the study. exclusion criteria: * subjects with a history of skin sensitivity to any of the components of the study product * subjects whose wound is infected * subjects who have participated in a previous clinical study within the past 3 months * subjects' with a known history of poor compliance with medical treatments * subjects who are pregnant (where pregnancy is a possibility, a pregnancy testing kit will be provided) * necrotic/sloughy wounds unless surgically debrided prior to enrolment * medical or emotional risk associated with the potential biopsy that outweighs the risk of not taking a biopsy as determined by the investigator * subjects exhibiting any other medical condition which, according to the investigator, justifies the subject's exclusion from the study * subjects with impaired renal function
a multicentre retrospective study on bicuspid aortic valve

Conditions: Bicuspid Aortic Valve

Summary: bicuspid aortic valve (bav) is a common congenital heart disease with an incidence ranging from 0.16% in asians to 2% in westerners. asian populations with bav have different morphological characteristics from those of the western populations, and further elucidation of these differences will serve as a guide for the treatment and follow-up of asian patients. therefore, we conducted this multicentre retrospective study to analysis the clinical features, long-term development and surgical prognosis of bav .

bicuspid aortic valve (bav) is a common congenital heart disease with an incidence ranging from 0.16% in asians to 2% in westerners, and more than one half of patients require medical or surgical treatment within 20 years of diagnosis. therefore, early diagnosis and effective treatment can help to reduce the incidence of irreversible cardiac impairment and adverse outcomes such as sudden death. asian populations with bav have morphological characteristics that differ from those of the western populations, and further elucidation of these differences could serve as a guide for the treatment and follow-up of chinese patients. based on the above background, we conducted this multicentre retrospective study. we will search for patients diagnosed with bav by echocardiography or other imaging examinations from december 2021 to october 2022 at nanjing gulou hospital, jiangsu provincial hospital and nanjing children's hospital; collect clinical symptoms, signs and examination results of them; find out the specific surgical plan and time of surgery if they have undergone surgery; follow up for symptoms, medication and reexamin echocardiography to confirm any endpoint events.

Eligibility criteria:
inclusion criteria: * all patients with a suspected diagnosis of bicuspid aortic valve by echocardiogram from december 2021 to october 2022 exclusion criteria: * patients with suspected bicuspid aortic valve not clearly diagnosed by echocardiography and not confirmed by cardiac surgery

Keywords: bicuspid aortic valve echocardiography long-term progress
wheel assisted running training (wart) in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: the purpose is to evaluate the effects of adding a wheel assisted running training (wart) to a conventional mixed physical activity training (ct) program on walking and gross motor function in trained children with cerebral palsy (cp). method entails recruiting thirty children with cp (16 females, 14 males), with mean (sd) age 11.8 (3.5) and training experience 3.4 (3.5), years were assigned to either wart or ct groups. the energy expenditure index (eei), the gross motor function measure 66 (gmfm), self-selected and fast walking velocity (ssv and fv, respectively), and cadence are administered by a trained physical therapist. the intervention period is six months, with two sessions per week.


Eligibility criteria:
inclusion criteria: * (a) medical diagnosis of cerebral palsy; * (b) ability to comprehend instructions in a group setting; * (c) no medical procedures involving the lower limbs (including casting and botox injections) during the last six months prior to pre-testing; * (d) able to walk three minutes at a self paced speed; * (e) no seizures during the last year, and (f) functional performance levels between ii-iv of the gross motor functional classification system (gmfcs) exclusion criteria: * (a) gmfcs i or v; * (b) not being able to comprehend or comply with instructions.

Keywords: training exercise gait
tracheostomized copd patients and non invasive mechanical ventilation

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: the purpose of this study was to determine occurrence of ventilator associated pneumonia (vap) in tracheostomized patients with copd discharged in invasive mechanical ventilation (imv) compared to patients with cpopd discharged with tracheostomy but in non invasive mechanical ventilation (nimv).

acute respiratory failure due to copd is often treated with invasive mechanical ventilation through endotracheal intubation, followed by placement of a endotracheal canula. however, invasive ventilation is at risk of infective complications and is difficult to manage at home. in particular, invasive mechanical ventilation may be associated with ventilator associated pneumonia (vap). vap is usually suspected when the individual develops a new or progressive infiltrate on chest radiograph, leukocytosis, and purulent tracheobronchial secretions. when possible, we tried to put these tracheotomized patients in non invasive mechanical ventilation (nimv)to avoid vap. this population was followed for eight consecutive years and compared with patients in invasive home mechanical ventilation (imv).

Eligibility criteria:
inclusion criteria: * clinical diagnosis of copd * tracheostomy * need of domiciliary invasive / non invasive ventilation exclusion criteria: * patients with copd weaned from invasive / non invasive mechanical ventilation * lack of tracheostomy

Keywords: pulmonary disease, chronic obstructive. tracheostomy. invasive mechanical ventilation. non-invasive mechanical ventilation.
evaluation of efficacy and tolerance of joe on 4 to 11 years old asthmatic patients of gina 2,3,4 and 5 grades

Conditions: Asthma in Children

Summary: the main objective of this study is to evaluate efficacy and safety of patient's learning in self-taking of prescribed asthma maintenance treatments and provided by joe (a new dtx), on the number of severe exacerbations in children with an asthma graded 2, 3, 4 and 5 according to gina classification.

a new device, named joe, manufactured by ludocare, is available since 2019 in france. this new device, compact and connected, was designed to be easy to use by children suffering from chronic disease. joe is a robot designed to improve compliance with asthama maintenance treatments.to confirm efficacy and safety of a patient's learning in self-taking of asthma maintenance treatments provided by joe, it has been decided to carry out a clinical study in 4 to 11 years old patients and suffering from asthma graded 2, 3, 4 or 5 according to gina classification. these patients will be recruited by pneumo-pediatricians at hospital or in private practice. the study is a phase 3, multi-center, prospective, open, 2-parallel groups, randomized and controlled study. each patient will be randomly allocated in one of two studied treatment groups: standard asthma maintenace treatment (group sct) vs standard asthma maintenance treatment + joe (a new dtx) (group sct + joe). patients meeting eligible criteria will be included at day 0 (visit v0). for each patient the maximal duration of this study will be 12 months. at day 7 a phone call is planned to evaluate patient/parent's motivation and to detect potential technical and/or therapeutic problems. three visits are planned then after at4 (m4), 8 (m8) and 12 (m12) months.

Eligibility criteria:
inclusion criteria: * 4-11years old, * able to use joe * persistent uncontrolled asthma, graded 2, 3 , 4 or 5 on gina classification * maintenance treatment since at least 3 months * having given their informed written consent exclusion criteria: * asthma naïve-treatment child * without regular follow-up with the investigator * participating to another interventional study, with another disease, other treatments or planned modification of prescribed treatments that could interfere with studied disease

Keywords: asthma, children, prevention, severe asthma exacerbations
regimen optimization study

Conditions: Kidney Transplantation

Summary: patients who undergo a kidney transplant require prolonged therapy with drugs that suppress the immune system (called immunosuppressive regimens) to stop the immune system from attacking the transplanted kidney in order to limit damage to or the possibility of rejecting the transplanted kidney. the purpose of this study is to evaluate benefits and risks of two immunosuppressive regimens (belatacept with everolimus or tacrolimus with mycophenolate mofetil) following thymoglobulin induction and rapid corticosteroid withdrawal.

calcineurin inhibitor (cni)

Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * men and women, aged 18 to 75 * serologic test results are positive for past exposure to epstein barr virus (ebv+) * diagnosed with end stage renal disease (esrd) and scheduled to undergo transplantation of a non-hla identical, living or standard criteria deceased donor kidney exclusion criteria: * primary cause of esrd is: primary focal segmental glomerulosclerosis; or type i or ii membranoproliferative glomerulonephritis; or hemolytic uremic syndrome / thrombotic thrombocytopenic purpura * had a previous graft loss due to acute rejection * at increased immunologic risk of graft loss due to panel reactive antibodies (pra) \>20% or need for desensitization therapy * scheduled to receive a: kidney from identical twin; or paired kidney; or kidney from a cytomegalovirus(cmv) positive donor when recipient is cmv negative; or kidney from an extended criteria donor * have a body mass index (bmi) of \> 35 kg/m2 for nondiabetics or \> 30 kg/m2 for diabetics * diagnosed as hepatitis b positive; or hepatitis c positive; or hiv positive; or currently or previously active or inadequately treated latent