Kornimate/medical-research-clean huggingface dataset:
the outcome of ahmed glaucoma valve in difficult glaucoma cases

Conditions: Glaucoma, Open-Angle; Glaucoma Secondary; Glaucoma, Neovascular

Summary: the clinical difference (mean iop, success rate, and complications) on using s2 and fp7 models of ahmed glaucoma valve that had similar dimensions and different materials used for their construction in one year follow up was evaluated.

refractory glaucoma is a difficult subject; many glaucoma devices are tried to reduce iop. glaucoma devices is now an integral part of glaucoma surgery. agv is commonly used. the investigators need to compare the efficiency and failure rate of two models of agv. the point that is the biological reaction around capsule can affect the efficiency.

Eligibility criteria:
inclusion criteria: 1. primary glaucoma patients with repeated failed trabeculectomy or other intraocular surgery. 2. patients had secondary glaucoma known to have a high failure rate with trabeculectomy such as neovascular, uveitis, post keratoplasty glaucoma or iridocorneal endothelial syndrome-associated glaucoma. exclusion criteria: 1. patients lacked light perception, unwilling or unable to give informed consent, lived out of the area and were expected to be unavailable for follow-up visits, 2. patients had previous aqueous shunt implanted in the same eye, other external impediment to supero-temporal drainage device implantation. 3. patients had silicone oil, vitreous in the anterior chamber sufficient to require a vitrectomy. 4. patients had uveitis associated with a systemic condition like juvenile rheumatoid arthritis. 5. patients had nanophthalmos, sturge-weber syndrome or other conditions associated with elevated episcleral venous pressure. -

Keywords: glaucoma-ahmed-valve-s2-fp7-iop-encapsulation
pharmacokinetic equivalence of calcium gluconate and calcium chloride in parturients

Conditions: Postpartum Hemorrhage; Pregnancy Related; Hypocalcemia; Parturition Complication

Summary: calcium is a life saving medicine in the care of parturients. it has many important uses including treatment of hypocalcemia, treatment of magnesium toxicity, prevention of hypocalcemia during blood transfusion (of citrate containing blood products), treatment of hyperkalemia, and others. recent clinical trials also suggest that calcium given after cord clamping may decrease blood loss in patients undergoing cesarean delivery. 2 fda approved forms of calcium can be given intravenously: calcium chloride and calcium gluconate. over the last decade there have been times with drug shortages of either calcium chloride or calcium gluconate. so there have been and likely will continue to be times when one formulation or the other may not be adequately available. despite the importance of calcium and the frequency in which it is used in parturients, there are no published studies in parturients to determine dose equivalence between calcium gluconate and calcium chloride. in this study the investigators will determine the population pharmacokinetics of calcium gluconate and calcium chloride in parturients and calculate the dose equivalent ratio the two drugs. this will help clinicians select appropriate doses of calcium and provide resilience to the drug supply chain in our era of frequent drug shortages.


Eligibility criteria:
inclusion criteria: pregnant female subjects delivering at the study institution via scheduled cesarean delivery at term (\>=37 weeks gestation) exclusion criteria: 1. severe range blood pressure (bp \>160/\>110) within the 48 hours prior to delivery 2. patient age \ 45 years 3. renal dysfunction with serum cr \> 1.0 mg/dl 4. known history of congenital or acquired cardiac disease or history of arrhythmia 5. patient taking digoxin 6. patient currently taking a calcium channel blocker 7. weight \ 100kg, or 8. receiving magnesium infusion within 24 hours prior to or during cesarean delivery 9. administration of intraoperative doses of calcium by the anesthesiology team for clinical indications
investigation of different relaxation techniques in eliciting a relaxation response

Conditions: Stress, Psychological

Summary: while the stress response, characterised by an increase in heart rate, blood pressure, and cortisol, has evolved to ensure the survival of the organism in face of danger, chronic stress due to psychological stressors can be harmful. the opposite of the stress response is the "relaxation response". mind-body techniques such as meditation, guided imagery and music therapy are thought to induce this response. the relaxation response is characterized as a wakeful hypometabolic state, where a decrease in central nervous system arousal is observed. some studies reported a reduction in stress hormones, and in symptoms of anxiety and depression following the use of mind-body relaxation techniques. other studies noted a reduction in stress measured using physiological measurements such as heart rate and blood pressure. light therapy is another technique that is suggested to induce physiological changes similar to those seen in the relaxation response. some studies have shown a reduction in heart rate, blood pressure, oxygen consumption and carbon dioxide production following exposure to blue light. these relaxation therapies can be useful for the general population and for vulnerable groups where alternative therapies, such as medication and psychotherapy, are difficult. limited amount of studies have quantified the decrease in stress in physiological measurements such as heart rate and blood pressure. the aim of this study is to investigate which relaxation technique among five different interventions (and one control) is the most effective in improving relaxation and reducing stress in adult women of reproductive age (18-45 years). the results of this study will be used to inform the intervention of a study testing the impact of relaxation therapy on breastfeeding outcomes in mothers of late preterm infants.


Eligibility criteria:
inclusion criteria: * women of reproductive age (18-45 years) * fluent in english exclusion criteria: * any condition that may affect blood pressure, heart rate or energy expenditure i.e hypertension, hyperthyroidism, heart failure * smokers * recent surgeries or injuries

Keywords: meditation music relaxation light therapy stress
clinical trial to compare the pharmacokinetics of a pregabalin controlled release tablet 300mg and immediate release formulation

Conditions: Healthy

Summary: the purpose of this study is to compare the pharmacokinetics profiles of pregabalin sustained release tablet (300mg) to immediate release capsule(150mg \* 2) while multiple dosing.


Eligibility criteria:
inclusion criteria: * 19\~44 aged healthy adult. * someone tho has at least 50kg body weight and ideal body weight ±20% exclusion criteria: * someone has acute symptom at screening phase * someone has any disease or symptoms which is clinically significant * someone had been determined during healthy examination in screening period * ast or alt \> 1.25 times than normal * total bilirubin \> 1.5 times than normal * someone who has a history of allergy, anaphylaxis, drug abuse or misuse. * someone who had enrolled to other clinical trial within the last 60 days. * someone who had donated blood within the last 60 days. * someone who can't take a meal derived from this trial. * someone who has taken abnormal meals like which can affect to drug adme * someone who has taken other etc drugs or oriental drugs within the last 14 days, or otc drugs within the last 7 days * someone who has taken caffein continuously (coffee or green tea more than 5 cups per a day) or took caffein since 24hours before. * someone who has taken alcohol more than 30g/day or smoked more than 10 piece of tobacco/day. * someone who has galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption.

Keywords: neuropathic pain pregabalin
cycling and treadmill with dual task for parkinson's disease improvement

Conditions: Parkinson Disease(PD)

Summary: motor impairment in lower extremities is common in individuals with parkinson disease (pd). development sensitive test for early motor deviations is important. conventional walking test cannot induce the pd related motor impairments, such as freezing of gait. therefore, finding a safe substitute test to induce pd related motor impairments is important. studies showed that working memory related dual task walking was a sensitive test for pd. however, the optimal cognitive test needs to be clarified. studies also showed that the neuromuscular control mechanism of leg movements during cycling were similar to those during walking. therefore, dual task cycling test is potential to be a safe and sensitive testing model. studies showed that exercise could improve cognitive function and induce brain plasticity. dual task exercise training was shown to be more effective than single task exercise training for older people to prevent fall. whether the added cognitive task could improve to detriment brain plasticity in pd should be investigated. transcranial magnetic stimulation can evaluate the motor cortex plasticity on-invasively and can evaluate the exercise induced brain plasticity. the purpose of this three-year project is to develop pd-sensitive. the purposes of the first year are to translate the dual task walking test to dual task cycling test, and to establish the reliability of the dual task cycling test. the purposes of the second year are to compare the motor cortex plasticity induced by single task cycling versus dual task cycling and to compare the difference response between pd and healthy control people. the purpose of the third year is to evaluate the effect of 8 week long term cycling training or treadmill training of individuals with pd on motor cortex plasticity, dual task performance, and ambulation ability.


Eligibility criteria:
health subjects: exclusion criteria: * musculoskeletal injuries on legs. * osteoporosis. pd subjects: inclusion criteria: - clinical diagnosis of parkinson disease. exclusion criteria: * musculoskeletal injuries on legs * osteoporosis. * any peripheral or central nervous system injury or disease patients.

Keywords: gait cycling training treadmill training dual-task walking dual-task cycling
neuralgic amyotrophy: central reorganization and rehabilitation after peripheral dysfunction

Conditions: Neuralgic Amyotrophy; Neuralgic Amyotrophy, Hereditary; Parsonage Turner Syndrome; Brachial Neuritis

Summary: this study evaluates the effect of a specific, multidisciplinary and personalized rehabilitation program compared to usual care, on motor control and functional disability in patients with neuralgic amyotrophy. half of the participants will start with the 17-week specific rehabilitation program while the other half will first continue their usual care for 17 weeks, after which they will also receive the 17-week specific rehabilitation program.

neuralgic amyotrophy (na) is a common (incidence 1:1000) peripheral nervous system disorder caused by acute autoimmune inflammation of the brachial plexus, the nerve bundle going to the shoulder and arm. many na patients develop abnormal motor control of the shoulder region (i.e. scapular dyskinesia), which persists even after the peripheral nerve damage has recovered. this suggests that persistent scapular dyskinesia in na may result from (mal)adaptive changes in the central motor system. clinical experience shows that the specific, multidisciplinary and personalized rehabilitation program, focused on cognitive motor control can restore scapular dyskinesia in na patients. this indicates that impairments in the central motor system likely play a role in persistent scapular dyskinesia and that specific rehabilitation may restore any alterations in central motor control. we hypothesize that the specific rehabilitation program, focused on cognitive motor control is more effective in improving functional disability than usual care and that it can reverse maladaptive changes in central motor control.

Eligibility criteria:
inclusion criteria: * (suspected) diagnosis of neuralgic amyotrophy * in subacute or chronic phase of neuralgic amyotrophy (\>2 months after attack onset) * right-handed * neuralgic amyotrophy predominantly present in right upper extremity * presence of scapular dyskinesia exclusion criteria: * patients in the acute phase of na (characterized by severe pain and inflammation of the brachial plexus) * (prior) na attacks of the lumbosacral plexus or the left upper extremity * sever comorbidity * any (bio)mechanical constraints of the shoulder girdle * any other central nervous system, neurological, or neuromuscular disorder

Keywords: physical therapy occupational therapy rehabilitation motor control
comparison of two pharmacist-led population management approaches to increase monitoring of vitamin b12 and serum creatinine levels for patients on metformin

Conditions: Type 2 Diabetes; Vitamin B12 Deficiency; Neuropathy; Anemia

Summary: the purpose of this project is to compare two pharmacist-led population management strategies designed to increase the rate of appropriate monitoring of vitamin b12 and serum creatinine for patients taking metformin.


Eligibility criteria:
inclusion criteria: * on metformin for at least one year * activated patient portal for electronic messaging * patient of an attending physician at ohio state general internal medicine * no serum vitamin b12 and/or no serum creatinine measurement in the past year

Keywords: metformin vitamin b12 deficiency population management pharmacist
mhealth intervention for improving eye health at community level

Conditions: Visual Impairment

Summary: this study is a community trial that aims to establish and evaluate an mhealth screening and promotional tool for improving eye health in iran. sampling frame is a region in tehran province with around 1 million sub-urban and rural inhabitants. investigators have obtained the list of health centers and their underserved population from the health authorities. in this region, health services are delivered through rural health houses, urban health posts and overhead health centers (221 units in total). investigators choose 27 units using cluster random sampling method with a probability proportional to size strategy, then investigators randomly assign them into three arms (explained below). the interventions will be at community level with the community as the unit of randomization. arm 1- training of the primary health care (phc) workers + phc workers will be empowered with the mhealth tool to monitor, screen and promote community members arm 2- phc system will be strengthened with health promotion and screening programmes (same content as the mhealth tool) and phc workers will deliver eye health messages and screening tests by the conventional facilities. arm 3: control group: only observation and registering of routine care


Eligibility criteria:
inclusion criteria: * inclusion criteria were living in one of the non-institutionalized urban or rural residential areas in one of the survey area, being resident in the same address for at least 6 months during the year before the enrolment, age 50 and over and iranian nationality.
deep margin elevation vs crown lengthening

Conditions: Endodontically Treated Teeth

Summary: the present clinical trial will be conducted to reject or accept the null hypothesis that in endodontically treated posterior teeth with deeply located proximal margins, will the deep margin elevation will have better results from surgical crown lengthening in terms of biological criteria?


Eligibility criteria:
inclusion criteria: * patients underwent endodontic treatment in the posterior region * 18-40 years * male and females * medically free patients * patients with healthy periodontium * patients with thick biotype. * patients having proximal margins violating the biological width exclusion criteria: * patients with chronic periodontal disease. * patients with persistent poor oral hygiene. * patients with unsuccessful root canal treatment. * periapical abscess or fistula. * patients with proximal margins beyond the bone level. * patients with developmental dental anomalies. * patients undergoing or will start orthodontic treatment * patients with removable prosthesis
evaluation of etc-1002 in participants with hypercholesterolemia and hypertension

Conditions: Hypercholesterolemia; Hypertension

Summary: this phase 2 study will assess the efficacy and safety of etc-1002 monotherapy versus placebo in participants with hypercholesterolemia and hypertension.


Eligibility criteria:
inclusion criteria: * mean 24-hour ambulatory sbp greater than or equal to 130 mmhg * or- mean 24-hour ambulatory dbp greater than or equal to 80 mmhg * fasting ldl-c between 100 and 220 mg/dl * fasting triglycerides less than 400 mg/dl * body mass index (bmi) between 18 and 45 kg/m2 exclusion criteria: * known or suspected secondary hypertension or history of malignant hypertension * taking more than two anti-hypertension medications at the first visit * history or current clinically significant cardiovascular disease * history or current type 1 diabetes or type 2 diabetes

Keywords: ldl cholesterol
the benefits of intensive glycemic control in elderly patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: aims/hypothesis: populations worldwide are aging and type 2 diabetes is common in individuals aged \>80 years. the important issue that needs to be considered is whether tight glycemic control is benefits for elderly patients with type 2 diabetes. the benefits of intensive glucose control remain uncertain for the heterogeneous population of older diabetic patients due to a lack of clinical trial data evaluating the benefits of long-term intensive glucose control in older patients. this study is designed to provide reliable evidence on the balance of benefits and risks conferred by intensive glucose control in elderly patients with type 2 diabetes methods: this is a prospective, randomized, open-labeled, controlled design to assess the benefits of treating elderly patients with type 2 diabetes. the study will include 208 elderly patients with type 2 diabetes and follow-up for 5 years. eligible patients are randomized to receive intensive (a1c \<7.0%) or conservative (a1c around 8.0%) glycemic control. the primary study outcomes are a composite of macrovascular events and a composite of microvascular events, considered both jointly and separately. the secondary outcomes are death from any cause, death from cardiovascular causes, total coronary events, total cerebrovascular events, heart failure, peripheral vascular events, all cardiovascular events, and hospitalization for 24 hours or more. expected results: this study is designed to provide reliable evidence on the balance of benefits and risks conferred by intensive and conservative glucose control in elderly patients with type 2 diabetes. once completed, this trial will clearly influence the management of elderly patients with type 2 diabetes, regardless of the results.


Eligibility criteria:
inclusion criteria: * men or women aged ≥80 years at time of randomization.there is no upper age limit. * be able to walk by themselves * they had their first diagnosis of type 2 diabetes mellitus at age 30 years or older. exclusion criteria: * known advanced diabetic complications (such as proliferative retinopathy, chronic kidney disease stage iv or above). * overt clinical congestive heart failure (chf) requiring treatment with a diuretic or ace inhibitor. * previous documented cerebral or subarachnoid haemorrhage in the last 6 months * condition expected to severely limit survival * clinical diagnosis of dementia * resident in a nursing home

Keywords: type 2 diabetes elder patients glycemic control men or women aged ≥80 years at time of randomization. there is no upper age limit. be able to walk by themselves they had their first diagnosis of type 2 diabetes mellitus at age 30 years or older.
therasphere post-approval study to calculate the radiation-absorbed dose of tc-99m maa.

Conditions: Hepatocellular Carcinoma

Summary: the therasphere post-approval study is a post-market, prospective, single-arm, open-label, observational study to support the use of therasphere for the treatment of hepatocellular carcinoma (hcc).

every patient being treated with therasphere needs to have a screening procedure with the administration of a radioactive product named tc-99m maa (called pre-treatment mapping). this screening procedure aims to determine if the patient can be treated with therasphere. the purpose of this study is to better understand the dose of radiation that is absorbed by the body and the risk of tc-99m maa to the whole body and other organs around the liver. the study will determine the amount of tc-99m maa that stays in the body and organs up to 24 hours after the administration.

Eligibility criteria:
inclusion criteria: 1. patients 21 years and older 2. written informed consent 3. patients who receive tc-99m maa while being evaluated for therasphere treatment. exclusion criteria: 1. patients who are contraindicated for therasphere treatment. 2. patients who are contraindicated for tc-99m maa per the applicable package insert. 3. patients who do not receive tc-99m maa during pre-treatment y-90 mapping

Keywords: carcinoma carcinoma, hepatocellular neoplasms, glandular and epithelial neoplasms by histologic type neoplasms adenocarcinoma liver neoplasms digestive system neoplasms neoplasms by site digestive system diseases liver diseases