Kornimate/medical-research-clean huggingface dataset:
quality of care in french hiv infected patients

Conditions: HIV

Summary: the objective of the dataids cohort is to continue a long-term, prospective collection of clinical, laboratory and therapeutic data on a large cohort of hiv infected patients seeking care in 15 hiv centers in france in order : 1. to provide and develop a surveillance system to describe clinical practice and temporal changes in the clinical course of hiv and hiv-related co-infections and co-morbidities in france. 2. to assess the factors associated with the clinical, immunological and virological course of hiv infection and hiv-related co-infections and co-morbidities the specific objectives are as follows * to continue surveillance of hiv infection in france to describe temporal changes * to evaluate the efficacy of art and factors associated with art efficacy * to monitor the uptake and outcome of hcv therapy

the dataids cohort is a prospective observational cohort of 30,000+ patients followed in 15+ hiv centers scattered throughout france. the dataids cohort is an ongoing collaboration and patients have been enrolled into the study since 2010; the data are collected from the clinics as part of routine care. included patients should be patients who had a scheduled visit in the outpatient clinic regardless of cd4 cell count, hiv viral load or art status. for all hiv patients enrolled and under follow up, demographic data, immunological and virological data, serological evidence for infection with hepatitis b virus (hbv), hepatitis c virus (hcv), or syphilis, laboratory, therapeutic and clinical data are collected annually.

Eligibility criteria:
inclusion criteria: * hiv-1 infected patients regardless of cd4 cell count and antiretroviral therapy status exclusion criteria: * patients under 18 years of age * patients without written informed consent

Keywords: hiv hepatitis c comorbidities aids
controlling and lowering blood pressure with the mobiushdtm device

Conditions: Hypertension

Summary: to evaluate the safety and performance of the mobiushd system in subjects with resistant hypertension.

this is a prospective, randomized, double-blind, sham-controlled, multi-center post market study investigating the efficacy and safety of mobiushd system, and the efficacy of the mobiushd device in lowering mean systolic 24-hour abp in subjects with resistant hypertension.

Eligibility criteria:
inclusion criteria: * aged 18-70 years; * diagnosed with resistant hypertension; * a mean systolic 24-hour abp of 135-170 mmhg following at least 30 days on a stable antihypertensive medication regimen (no changes in medications or dose). * a mean systolic 24-hour abp of 135-170 mmhg after washout of all antihypertensive medications. exclusion criteria: * known or clinically suspected baroreflex failure or autonomic neuropathy * treatable cause of resistant hypertension * hypertension secondary to an identifiable and treatable cause other than sleep apnea
microperimetry and optical coherence tomography (oct) in idiopathic epiretinal membrane

Conditions: Epiretinal Membrane

Summary: purpose: to evaluate macular sensitivity and its correlation with visual acuity and spectral domain optical coherence tomography (sd-oct) in eyes with idiopathic epiretinal membrane (erm). design: cross sectional case-control series. methods: setting: dijon university hospital. patients: forty nine patients (49 eyes) with idiopathic erm and twenty-seven healthy patients (27 eyes) as a control group. main outcome measurement: microperimetry, spectral domain optical coherence tomography (sd-oct).


Eligibility criteria:
inclusion criteria: * epiretinal membrane exclusion criteria: * age related macular degeneration * diabetic macular edema

Keywords: microperimetry oct idiopathic epiretinal membrane
copeptin and thirst: possible predictive markers of effectiveness of bariatric surgery?

Conditions: Obesity

Summary: prospective, non-pharmacological, spontaneous, single-center, interventional study.

coptbar is a prospective, nonpharmacological spontaneous single-center interventional study. laboratory tests and imaging study (complete abdomen ultrasonography) for monitoring patients will be conducted in accordance with normal clinical practice. in addition, periodic copeptin assay will be performed. each patient, within the study protocol, will be evaluated for 12 months; thereafter, each patient will fall under the follow-up visits provided by normal clinical practice and by corporate diagnostic therapeutic pathway (pdta).

Eligibility criteria:
inclusion criteria: * bmi ≥ 40 in the absence of comorbidities; bmi ≥ 35 associated with at least one comorbidity * age ≥ 18 and less than or equal to 65 years * written informed consent obtained exclusion criteria: contraindications to bariatric surgery: * severe psychiatric illness in the decompensation phase; * drug or alcohol abuse; * patient unwilling to follow periodic checkups and a dietary regimen pregnancy or lactation. factors that could alter adh/copeptin: * obesity induced by other endocrinopathies or medications; * diabetes mellitus of any type; * malignant neoplasms or ongoing acute disease; * organ failure or chronic cns and kidney disease; * hydro-electrolyte alterations; * use of drugs that interfere with pituitary-adrenal axis, diuretics, anti-psychotics and psychopharmacological therapies, glp1 receptor agonists, estro-progestin therapy.
convolutional neural network for the detection of cervical myelomalacia

Conditions: Cervical Myelopathy

Summary: deep learning technology has been used increasingly in spine surgery as well as in many medical fields. however, it is noticed that most of the studies about this subject in the literature have been conducted except of the cervical spine. in this study, we aimed to demonstrate the effectiveness of the deep learning algorithm in the diagnosis of cervical myelomalacia compared to conventional diagnostic methods. artificial neural networks, a machine learning technique, have been used in several industrial and research fields increasingly. the development of computational units and the increasing amount of data led to the development of new methods on artificial neural networks

cervical myelopathy (cm) is a frequent degenerative disease of the cervical spine that occurs as a result of compression of the spinal cord. in evaluating of this disease and determining treatment options, the patient's clinic and radiological modalities should be evaluated together. the current imaging procedures for cm are plain roentgenograms, computed tomography and magnetic resonance imaging (mri). however, mri in cm is more valuable in evaluating of the disc, spinal cord and other soft tissues compared to other imaging methods. artificial intelligence technologies also used in many health applications such as medical image analysis, biological signal analysis, etc. in this study, we aimed to demonstrate the effectiveness of the deep learning algorithm in the diagnosis of cervical myelomalacia compared to conventional diagnostic methods.

Eligibility criteria:
inclusion criteria: * the patients with classical cervical myelomalacia sypmtoms such as neck pain and stiffness, weakness and clumsiness at the upper extremities or gait difficulties and radiological findings of spinal compression * 30-80 years age. exclusion criteria: * patients with a previous history of cervical spinal surgery and has a systematic disease (rheumatologic or neural disease) .

Keywords: neural network deep learning cervical myelopathy
improved breast mri with swift

Conditions: Breast Cancer

Summary: today's medical imaging methods have insufficient specificity for reliable differentiation between benign and malignant breast lesions in patients. pathologic evaluation is currently the only way to obtain a definitive diagnosis. this research will use a novel method of magnetic resonance imaging (mri), sweep imaging with fourier transform (swift), at a very high magnetic field (4 tesla) to distinguish malignant from benign breast lesions. this research will reveal whether the swift sequence bears new capabilities in medical imaging for breast cancer diagnosis.

patients will be asked to come to the center for magnetic resonance research (cmrr) at the university of minnesota. researchers will interview the patient and describe procedures and risks. an intravenous (iv) line will be placed in an upper extremity for infusing magnetic resonance imaging (mri) contrast dye. baseline mri scans will be done. these mri measurements will be compared with clinical, radiological and pathological findings (the gold standard). follow-up contact will occur within one year after the mri to determine whether a pathology report is available.

Eligibility criteria:
inclusion criteria: * women with a clinically or mammographically identified suspicious breast mass that is likely to be biopsied or surgically removed. exclusion criteria: * pregnancy * ferromagnetic implants * history of shotgun wounds and shrapnel * obesity (\>250 pounds) * cardiac pacemaker * incompatible implanted medical device * severe claustrophobia * major surgeries with potential of ferromagnetic implants * severe asthma and allergies * i-stat system, a handheld blood analyzer (i-stat) creatinine test, estimated glomerular filtration rate (gfr) \<30 * metallic object (greater than 2 cm in length) in the breast * metallic ink tatoo within 20 cm of the breast (approximately 8 inches)
cognitive function assessment in patients with focal brain injury

Conditions: Focal Brain Injury; Cognition

Summary: this research relates to the study of cognitive deficits related to various focal brain lesions and their localizations in the brain. it involves building a large database of behavioural responses measured during the performance of cognitive tasks in patients with focal brain injury, to allow to better understand function of brain.

the study of patients with focal lesions is at the origin of many key discoveries in the field of neurology and cognitive neuroscience. there are many mechanisms of injury in the brain. the investigators focus on delineated lesions (as opposed to panencephalic, infectious or traumatic lesions), including stroke, excision of intracranial expansive processes or cortectomies of epileptogenic foci. at the chuga, several hundred patients are hospitalized each year for stroke, several dozen patients are operated on brain tumor and about thirty patients benefit from surgical treatment for their epilepsy. post-injury cognitive disorders represent a large heterogeneous class of neurological disorders. they are differentiated by various clinical and neuropsychological profiles involving different higher functions such as attention, language, memory, decision-making or executive functions. this variability observed in these disorders complicates their characterization. especially, there is no, on a sufficiently large scale, data collection to establish whether cognitive deficits are explained by the relative contribution of the type of test used, the location of the lesion, the nature of the pathology and the post-injury delay. this requires a large cohort of patients. the objective of this project is precisely to build a structure-function database in patients with focal brain injury (post-stroke or post-cortical resection), with the aim of conducting a transnosographic and longitudinal study of brain functions in these patients. to the knowledge of the investigators, this type of approach has not yet been proposed. such a project should eventually lead to a better understanding of the nature of the cognitive deficits observed in different types of lesions, and to refine the correlations between structures and functions. this project is in line with the objectives set by the university hospital federation neuropsynov, which was labeled in 2015 (dir p. kahane, fhu-neuropsynov.chu-grenoble.fr) and aims to encourage transnosographic and translational studies of neurological and psychiatric diseases.

Eligibility criteria:
inclusion criteria: * male and female patients, 18-70 years old * a single, focal anatomical lesion of a given cerebral territory (post vascular, post surgical resection) documented by mri * intellectual ability and understanding of instructions compatible with the cognitive tasks to be performed exclusion criteria: * patient deprived of liberty * somatic disorder likely to affect cognitive abilities * pregnant or nursing woman

Keywords: behavioral performance cortical resection stroke
effect of high intensity laser versus plus exercises

Conditions: Effect of High Intensity Laser Plus Exercises on Wrist Pain

Summary: high-intensity laser therapy (hilt) has been used more recently in the therapeutic protocols of musculoskeletal pain management. this study is conducted to find out the effect of high intensity laser therapy only versus high intensity laser pulse exercises on level of wrist pain, function and joint position sense in girls gymnasts

effect of high intensity laser plus exercises on wrist pain ..three groups of gymnastics girls suffer from non specific wrist is allocating ..the first group will receive exercises only , the second will receive laser only while the third will receive exercises plus laser

Eligibility criteria:
inclusion criteria: * all girls diagnosed with generalized chronic wrist pain and referred by orthopaedic physician. * their age between 10-16 years old * they will be able to follow instructions. * all are medically stable exclusion criteria: * • bone fractures and tumors. * cases after plastic surgery. * hypertension (due to secondary vasoconstriction) * diabetes mellitus * pacemakers
the effect of time on the outcome of periodontal treatment.

Conditions: Periodontitis

Summary: re-evaluation after non-surgical periodontal treatment remains an integral part of comprehensive periodontal therapy. this re-evaluation determines if a patient is in need either of surgical periodontal therapy or a personalized program of supportive periodontal treatment. however important, this time point is yet to be determined.this interventional study aims to clarify which is the best time to re-evaluate the therapeutic result after non-surgical periodontal treatment.

this randomized clinical trial aims to clarify which is the best time to re-evaluate the therapeutic result after non-surgical periodontal treatment. for this purpose the participants will be recruited among people who come to the periodontal department of 251 hellenic air force hospital for periodontal treatment. each participant is going to submit informed consent in order to be included in the study. patients with the diagnosis of periodontitis will be submitted to non-surgical periodontal treatment with ultrasonic and manual scalers within two sessions, under local anaesthesia. the result of the treatment is going to be evaluated at 6, 12 and 24 weeks after treatment completion.

Eligibility criteria:
inclusion criteria: * systematically healthy adults * informed consent form completion * periodontitis diagnosis * patients not having received periodontal treatment since 12 months before exclusion criteria: * medical history that interferes with wound healing * antibiotic and anti-inflammatory drugs intake * medication that induces gingival enlargement * pregnancy/ lactation

Keywords: periodontitis re-evaluation non-surgical periodontal treatment
a sleep-oriented intervention for suicidal behaviors

Conditions: Insomnia; Suicidal Ideation

Summary: an open-label trial to investigate the use of a behavioral insomnia treatment for suicidal ideation.


Eligibility criteria:
* age 18 or older * clinically significant sleep disturbances * diagnosis of depression

Keywords: insomnia sleep behavioral medicine suicide suicidal ideation
clopidogrel versus ticagrelor in type-2 diabetes

Conditions: Coronary Artery Disease; Diabetes Mellitus

Summary: clotildia is a single-center, prospective, randomized, open label, cross-over study evaluating the effects of ticagrelor versus high-dose clopidogrel on endothelial function and platelet reactivity in patients with type-2 diabetes mellitus (t2dm) treated with percutaneous coronary intervention (pci).


Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus * stable coronary disease * coronary revascularization with pci at least 1 month prior to recruitment exclusion criteria: * acute coronary syndrome * platelet count \<70x109/l * active bleeding or bleeding diathesis * history of intracranial bleeding * gastrointestinal bleeding \<6 months * cerebrovascular accident \<3 months * history of malignancy * concomitant need for oral anticoagulant therapy * severe liver disease or chronic renal failure (glomerular filtration rate \<30 ml/min /1.73m2)
evalution the safety and efficacy in atopic dermatitis patients

Conditions: Atopic Dermatitis

Summary: a multi-center, open, long-term follow-up study to evaluate the efficacy and safety of furestem-ad inj. in patients with moderate to severe chronic atopic dermatitis: 5-year results from the k0102 extension study


Eligibility criteria:
inclusion criteria: 1. subject who enrolled k0102 clinical trial(parent study). 2. subjects who understand and voluntarily sign an informed consent form exclusion criteria: 1. in case follow-up is not possible from end of k0102 clinical trial to end of this study period 2. any other condition which the investigator judges would make patient unsuitable for study participation
a study of imvotamab in active, refractory idiopathic inflammatory myopathies

Conditions: Idiopathic Inflammatory Myopathies; Inflammatory Myopathies

Summary: the purpose of this study is to determine the safety and tolerability of imvotamab in patients with moderate-severe idiopathic inflammatory myopathies who have failed prior therapies. participants will be given imvotamab through a vein (i.e., intravenously).

this is a phase 1b, open-label study to determine the safety, tolerability, pharmacokinetics (pk), and pharmacodynamics (pd) of imvotamab in adult participants with active, refractory, moderate-severe idiopathic inflammatory myopathies. approximately 5-10 participants will be assigned.

Eligibility criteria:
key inclusion criteria: * age ≥ 18 years at the time of signing icf * diagnosis of probable or definite iim according to the 2017 european league against rheumatism (eular)/american college of rheumatology (acr) classification criteria for iim with subgroup classification of either dm, polymyositis (pm), anti-synthetase syndrome, or immune-mediated necrotizing myositis (imnm). * active iim despite treatment with corticosteroids and at least 1 immunosuppressive or immunomodulatory standard-of-care agent determined at the discretion of the investigator after at least 3 months of treatment. * if using oral corticosteroids (ocs), must be on a stable dose equivalent to ≤ 30 mg/day of prednisone for at least 4 weeks prior to first study treatment key exclusion criteria: * pregnant or breastfeeding or intending to become pregnant during the study or within 3 months after the final dose of imvotamab. * receipt of an investigational therapy less than 12 weeks or 5 drug-elimination half-lives (whichever is longer) prior to first administration of study treatment and during the study. * has inclusion body myositis or myositis-associated with other connective tissue disease.

Keywords: myopathies moderate-severe myopathy myositis
study evaluating the safety, immunogenicity and tolerability of meningococcal group b vaccine in healthy adults

Conditions: Meningitis, Meningococcal

Summary: to determine the safety \& immunogenicity of a potential vaccine against meningococcal b disease


Eligibility criteria:
inclusion criteria: * healthy 18-25 year olds exclusion criteria: * prior history of vaccination with any meningococcal vaccine * prior history of any invasive meningococcal disease

Keywords: vaccines healthy adults health adult meningococcal vaccines
preventive treatment of groin pain in football

Conditions: Healthy

Summary: groin pain represents a common issue in football. currently, there are no prevention protocols demonstrating real effectiveness. we aimed to investigate the possible positive effect of a prevention program for groin pain.forty-two élite male athletes belonging to a youth academy of a professional football club were recruited in this prospective, randomized, controlled, single-blind, study.


Eligibility criteria:
inclusion criteria: * subjects between the ages of sixteen and eighteen, belonging to the youth sector of a professional club. exclusion criteria: * presence of pain or injuries at the level of the hip-hip region at the initial assessment.

Keywords: groin injuries, soccer, athletes, pain, muscle strength
optical assessment on brain death via a oxygen supply procedure

Conditions: Brain Death

Summary: this study aims to evaluate brain death with optical probes. the changes of hemodynamic parameters including oxyhemoglobin (hbo2) and deoxyhemoglobin (hb) were detected by near infrared spectroscopy probes attached on the forehead of patients. a multiple-phase protocol at varied fraction of inspired o2 were utilized during the assessment.

brain death is an irreversible loss of all brain functions, and the assessment is crucial for organ supply for transplantation. the noninvasive, sensitive, universally available and timely ancillary method to assess brain death has not been established. this study aims to evaluate brain death with optical probes. the changes of hemodynamic parameters including oxyhemoglobin (hbo2) and deoxyhemoglobin (hb) were detected by near infrared spectroscopy probes attached on the forehead of patients. a multiple-phase protocol at varied fraction of inspired o2 were utilized during the assessment. the concentration changes ratios of oxyhemoglobin to deoxyhemoglobin (δ\[hbo2\]/δ\[hb\]) in the cerebral cortex of brain-dead patients were significantly higher than those of healthy subjects.

Eligibility criteria:
inclusion criteria: * patients who have had brain death or serious brain trauma. * healthy people who are interested in optical assessment of hemodynamic parameters exclusion criteria: * patients who are in pregnancy or have plan to conception. * patients who have vertebra surgery or have plan of surgery. * patients who are inappropriate to join this trial judged by the radiologists or specialists. * aids, active hepatitis, tuberculosis, syphilis * patients who regularly take anticoagulants, antiplatelet drugs

Keywords: brain death oxygen metabolism near infrared spectroscopy