Kornimate/medical-research-clean huggingface dataset:
impact on energy intake by implementing recommended food texture through dietary guidance

Conditions: Energy Intake; Activities of Daily Living; Quality of Life; Protein Intake; Fluid Balance; Lean Body Mass; Fat Mass; Weight

Summary: an intervention study on the effect of dietary guidance with focus on implementing recommended food texture, at the department of eating and swallowing difficulties, region midtjylland, denmark. energy- and protein intake, weightloss, bodymass composition, fluid balance and activities of daily living (adl), will be measured by bioimpedance spectroscopy, interviews and a questionnaire.

it is know that people with eating- and swallowing difficulties(known as dysphagia), is prone to weightloss due to insufficient energy- and protein intake, and a reduction in adl. adl will in this project have its focus on the eating situation. the projects research questions are: * will dietary guidance with texture implementation increase energy intake in patients being examined on an outpatient basis for dysphagia, based on the fiberoptic endoscopic evaluation of swallowing (fees) recommendation? * can a dietetic guidance with texture implementation increase quality of life and adl in patients with dysphagia? recruitment and data collection will take place at hammel neurocenter, dk. each patient will be included for eight weeks, after their first fees examination. the participants will be randomized to control or intervention, and strata into three groups based on fiberoptic endoscopic dysphagia severity scale (fedss) 1, 2-3 and 4. within the eight weeks, participants have to show up three times to measurements, interviews and questionnaire, in addition to this, the intervention groups will have three follow-up phone meetings.

Eligibility criteria:
inclusion criteria: * signed consent form * newly refered patients to fees examination * score 1-4 on fedss-scale * consumes 50% energy or more orally * consumes less energy than calculated energy need (harris-benedict) * individuals of full legal capacity * individuals above 18 of years * that the patient is capable of executing examinations exclusion criteria: * individuals with known eating disorders * ineligible individuals * individual in need of translator * individuals participating in another trial

Keywords: dysphagia dietary guidance energy- and protein intake food texture activities of daily living and quality of life
flortaucipir pet imaging in the preclinical, prodromal and dementia phases of alzheimer's disease

Conditions: Alzheimer Disease; Mild Cognitive Impairment

Summary: a phase 1 study designed to evaluate imaging characteristics of flortaucipir in the preclinical, prodromal and dementia phases of alzheimer's disease.

the australian imaging biomarkers and lifestyle study (aibl) is a multicenter multidisciplinary study of alzheimer's disease and aging funded by the commonwealth scientific and industrial research organisation (csiro) flagship initiative, involving research centers in both victoria and western australia. the goal of the a08 protocol was to further investigate the positron emission tomography (pet) imaging results with flortaucipir in patients across the ad spectrum from individuals with subjective memory complaints (smc) to those with dementia, based on recruitment into the parent aibl study.

Eligibility criteria:
inclusion criteria: * meet all inclusion criteria for the aibl study protocol, with amyloid pet conducted or planned and mri available * subjects in the mci and ad groups required to have a reliable caregiver capable of providing information about the subjects' symptoms exclusion criteria: * lifetime history of schizophrenia, schizoaffective disorder, or bipolar disorder * history of electroconvulsive therapy * mri contraindicated * claustrophobic or, otherwise, unable to tolerate the imaging procedure * current clinically significant cardiovascular disease or clinically significant abnormalities on screening electrocardiogram * history of additional risk factors for torsades de pointes * current clinically significant infectious disease, endocrine or metabolic disease, or pulmonary, renal, or hepatic impairment that the investigator believes would affect study participation * history of cancer (other than skin or in situ prostate cancer) within the previous 5 years * current drug or alcohol abuse/dependence * history of alcohol abuse/dependence with 2 years of the onset of the symptoms of dementia * females of childbearing potential who were not surgically sterile, not refraining from sexual activity, or not using reliable methods of contraception
a laboratory-based surveillance study of candida bloodstream infections (mk-0991-093)

Conditions: Candidemia

Summary: this study will evaluate the incidence rate of candida blood stream infection (candidemia) among people hospitalized in participating medical centers in brazil, and will assess the antifungal drug susceptibility patterns of candida clinical isolates. no hypotheses will be tested in the study. candida blood stream isolates collected from people hospitalized for any reason during the study period will be sent to a core mycology laboratory for antifungal drug susceptibility testing. all people who develop candidemia while hospitalized will be considered participants in the study.


Eligibility criteria:
inclusion criteria: * hospitalized in a participating medical center * developed candidemia blood stream infection (confirmed by isolation of candida species from blood culture)
a comparison of continuous moderate training and reduced high intensity interval training in obese young adults

Conditions: Obesity; Exercise; Oxygen Consumption

Summary: exercise is a key component of obesity management. obese subjects cannot attend or sustain exercise program because of increased general fatigue, dyspnea and muscle fatigue. and they feel more exertion when comparing with normal weight subjects. reduced-exertion high-intensity interval training (rehit) is a alternative method to continuous exercise programs. the investigators aimed comparing metabolic effects of rehit and continuous exercise in young adults, in this study.


Eligibility criteria:
inclusion criteria: * between the ages of 18-22, * bmi ≥ 30, * female gender, exclusion criteria: * smoking history, * having any metabolic disease except obesity,
cytokine profile in children with celiac disease

Conditions: Celiac Disease

Summary: celiac disease (cd) is an immune-mediated systemic disease that is elicited by consumption of gluten and related prolamines in genetically susceptible individuals. not only genetic but also environmental factors play an important role in cd pathogenesis. cd patients have imbalance in the gut microbiota, they have reduced number of bididobacterium species in feces and biopsies. up till now, only effective treatment for cd is life long adherence to gluten free diet. if gluten free diet is not strict that leads over the years to complications of disease, such as autoimmune diseases, psychiatric diseases, osteoporosis etc. that may be caused by continuous recirculation of activated immune cells between the inflamed organ and the periphery. to avoid complications of disease in long term the investigators want to test specific probiotic bacteria from bifidobacteria genus, that has has been in vitro studies recognized as anti-inflammatory. hypothesis 1. children with celiac disease on gluten free diet have a higher level of pro-inflammatory cytokine (tnf-alpha) and anti-inflammatory cytokine (il-10) in comparison with healthy controls. 2. 3 months after daily probiotic consumption tnf-alpha level decrease and il-10 level increase. in the investigators research will be selected 70 children, age from 2 to 18 years, divided in different groups: 1. group: 25 children with celiac disease on gfd for at least 3 months and will receive probiotic for 3 months. 2. group: 25 children with celiac disease on gfd for at least 3 months and will receive placebo for 3 months. 3. group: 20 healthy children


Eligibility criteria:
inclusion criteria: * celiac disease on gluten free diet exclusion criteria: * acute or chronic diseases, * permanent use of medication and * ingestion of antibiotics at least one month prior to study
nutrition intervention among stem cell recipients: post hospital discharge

Conditions: Hematopoietic Stem Cell Transplantation; Malnutrition

Summary: chemotherapy conditioning, preceding stem cell transplantation (sct), has been associated with severe gastrointestinal toxicity, commonly compromising patients' food intake, nutritional status and functioning level. malnutrition has been associated with worse functional status, reduced survival, increased rate of infections, complications, hospitalizations, and therapy toxicity in oncology patients. to date, there is no randomized controlled trials (rct) assessing the impact of a nutrition intervention on sct patients who remain at risk of malnutrition even 100 days post sct. the proposed study is a single center, prospective, rct with a parallel design that aims to assess the impact of a nutrition intervention on the nutritional and functional statuses of sct recipients 100 days post sct.

this study is a single center rct with a parallel design. it aims to improve the sct recipients' nutritional status and qol and reduce the associated morbidities. results of the study can guide the recommendations for the medical and nutritional outpatient assessment post sct. during the pre-sct workup, patients will be invited to participate in the study. around discharge from the hospital, recruited patients will be randomized to a control or an intervention group based on permuted block random sampling. patients in the nutrition intervention group (nig) will receive a tailored diet plan from the dietitian as well as regular outpatient follow-ups measuring and reinforcing compliance. patients in the control group (cg) will receive usual care; they will only be assessed in the nutrition clinics upon referral by the medical team. the body composition, quality of life (qol), physical activity (pa) level, nutrient intake, functional status and nutritional status of both groups will be evaluated at regular intervals during the hospital stay and post discharge through the patient generated subjective global assessment (pgsga), body impedance analysis (bia), handgrip strength, functional assessment of cancer therapy -bone marrow transplantation (fact-bmt), pa questionnaire and karnofsky scale. moreover, patients' food intake will be analyzed for its micronutrient and macronutrient content to assess the changes in nutrient analysis in the peri-transplantation phase. when applicable, bia and computed tomography (ct) tests will be compared for their agreements. considering a power of 80%, an attrition rate of 30% and a difference of 40% between the nig and cg groups, 52 patients need to be recruited in the study. analysis will be done based on 'intention to treat' and 'per protocol' analysis.

Eligibility criteria:
inclusion criteria: * adults admitted to the adult bmt service at aubmc * allogeneic or autologous sct * malignant or non-malignant indication for sct exclusion criteria: * patients who pass away before day +100 * patients who miss 2 assessment points
osteoporosis and mri study in hemophilia

Conditions: Bone Mineral Density; Hemophilia A; Hemophilia B

Summary: the purpose of this study is to evaluate bone mineral density in adult subjects with hemophilia versus a comparator population without hemophilia (non-hemophilia age- and gender-matched database) by using the following diagnostic means: dual-energy x-ray absorptiometry (dxa) scanning, clinical scales, quality of life (qol) scales and biomarkers. in addition to this osteoporosis study, hemophilic arthropathy of the knee with respect to loss of knee cartilage will also be explored by using magnetic resonance imaging (mri substudy). no investigational product will be dispensed.


Eligibility criteria:
inclusion criteria: * male and at least 25 years old at the time of screening * moderately severe or severe hemophilia a or b (factor viii or factor ix \<= 2% by chart documentation) * ambulatory (ie, not wheel chair dependent) * performance status - ecog of 0 or 1 (= out of bed at least 75% of time) * willing and able to comply with the requirements of the protocol and is able to give informed consent additional inclusion criteria for mri substudy: * baseline knee joint space width is \>= 3mm at the medial or lateral aspect of either knee as measured by weightbearing fixed flexion pa x-ray * able to undergo 1.5 or 3t mri exclusion criteria: * inability to position properly for dxa * presence of orthopedic hardware or other artifact in the lumbar spine (l1-l4) or either proximal femur * prior documentation of being hiv positive * radiosynovectomy or surgical synovectomy within the last 6 months * current or past treatment with bone active drugs * long-term corticosteroid use \[defined as 7.5-mg prednisone daily (or equivalent) for \>= 3 months\] * if subject is family member or employee of the investigator additional exclusion criteria for mri substudy: * any contraindication or relative contraindication to mri * less than 3mm knee joint space width at the medial and lateral aspect of both knees on baseline x-ray evaluation * knee bleed within 30 days of informed consent * prior total knee arthroplasty (tka)

Keywords: hemophilia
depression prevention program for american indian adolescents during and after pregnancy

Conditions: Depression; Pregnancy

Summary: this study will determine the effectiveness of the "living in harmony" depression prevention program in preventing depressive symptoms among pregnant american indian adolescents during pregnancy and after giving birth.

pregnancy among reservation-based american indian adolescents has become increasingly common. numerous psychosocial and environmental factors have put this population at high risk for pregnancy-related depression. depression during pregnancy and after giving birth is associated with reduced quality of life for both young mothers and their children. many reservations lack mental health services; therefore, an inexpensive intervention is needed to prevent depressive symptoms among pregnant adolescents who live on reservations. the duration of this study will vary for each participant, depending on the time of study entry. participants will be randomly assigned to receive weekly sessions of either the "living in harmony" program, consisting of cognitive behavioral therapy (cbt), culturally-relevant education, and support; or general depression-prevention education and support. participants' depressive symptoms will be assessed at study entry, at 4, 12, and 24 weeks after giving birth, and study completion. interviews and self-report scales will be used to assess participants.

Eligibility criteria:
inclusion criteria: * at 28th week or earlier of pregnancy * center for epidemiologic studies-depression scale (ces-d) score of 16 or higher * identified (by others and by self) as an american indian * currently live on an american indian reservation * parent or guardian willing to give consent, if applicable * willing and able to comply with all study requirements exclusion criteria: * diagnosis of major depressive disorder * current psychiatric disorder or condition requiring intervention or treatment * current participation in another mental or behavioral health study

Keywords: postpartum depression postpartum period indians, north american adolescent female cbt
an open-label study of ym087 (conivaptan) in patients with euvolemic or hypervolemic hyponatremia

Conditions: Hyponatremia

Summary: this study will investigate the application of a vasopressin antagonist in the treatment of hyponatremia most likely caused by inappropriate avp secretion. the population studied will include patients with euvolemic or hypervolemic hyponatremia.


Eligibility criteria:
inclusion criteria: * serum sodium levels less than or equal 130meq/l * euvolemic or hypervolemic hyponatremia exclusion criteria: * clinical evidence of volume depletion or dehydration * untreated severe hypothyroidism, hyperthyroidism, or adrenal insufficiency * uncontrolled brady-or tachyarrhythmias requiring pacemaker placement or treatment

Keywords: hyponatremia hypervolemic euvolemic treatment outcomes ym087
surveillance of patients with adenocarcinoma of the gastroesophageal junction or esophagus

Conditions: Adenocarcinoma Esophagus

Summary: the purpose of this study is to find out more information about patients who have cancer (adenocarcinoma) of the esophagus or gastroesophageal junction (gej) who have been treated with chemotherapy and radiation but have not had surgery. the study will follow patients for 5 years to monitor for their cancer and to see how the standard medical care affects the daily life of patients.


Eligibility criteria:
inclusion criteria: * adenocarcinoma of esophagus or gastroesophageal junction (nidus of the cancer within 5 cm from the gastroesophageal junction) confirmed by biopsy with clinical stage i, ii, or iii. the superficial adenocarcinoma of the esophagus will be excluded. * received no previous treatment for esophageal cancer. * measurable or evaluable disease * ecog performance status: 0 to 2 that is able to perform activities of daily living with minimal assistance * adequate bone marrow function (hemoglobulin ≥8 g/dl, neutrophil ≥1.5x109/l and platelet ( ≥100x109/l) * adequate liver function * bilirubin normal, meets 1 of the following criteria: * alkaline phosphatase (ap) normal and ast/alt ≤ 5 times upper limit of normal (uln) * ap ≤ 2.5 times uln and ast/alt ≤ 1.5 times uln * ap ≤ 5 times uln and ast/alt normal * adequate kidney function (creatinine ≤1.5 unl and creatinine clearance ≥ 60 ) * be at least 4 weeks from recent major surgical procedures. * patients must be able to understand the nature of the study and give written informed consent * at least one measurable lesion on ct, mri or esophageal barium exam. exclusion criteria: * age \ 80 years * contraindication for irradiation: complete obstruction of esophagus, deep esophageal ulcer, fistula to mediastinum, or hematemesis * participating in other clinical trials * pregnancy * clinically significant and uncontrolled major medical conditions including but not limited to active uncontrolled infection, symptomatic congestive heart failure, unstable angina pectoris or cardiac arrhythmia, psychiatric illness/ social situation that would limit compliance with study requirements * any medical condition, which in the opinion of the study investigator places the subject at an unacceptably high risk for toxicities
a clinical study of mk-4318 and diltiazem in healthy people (mk-4318-003)

Conditions: Healthy; Pain

Summary: the goal of this study is to learn what happens to mk-4318 in a person's body over time. researchers will compare what happens to levels of mk-4318 in people's blood when it is taken with and without diltiazem. researchers also want to learn about the safety of mk-4318 taken with and without diltiazem and if people tolerate them.


Eligibility criteria:
inclusion criteria the main inclusion criteria include but are not limited to the following: * is in good health based on medical history and physical examination * has a body mass index \>18 and ≤32 kg/m\^2, inclusive exclusion criteria the main exclusion criteria include but are not limited to the following: * has a history of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases * has a history of cardiac arrythmia or recurrent unexplained syncopal events
acceptability and tolerance study of new oral nutritional supplement prague

Conditions: Malnutrition

Summary: tolerance and acceptability of new oral nutritional supplement - aymes prague

to evaluate tolerance and acceptability of aymes prague in patients requiring supplementary oral nutritional support compared with currently available alternatives, measuring outcomes of gi effects, compliance, product preference,convenience etc. to obtain data to support an acbs submissions for aymes prague (to allow for prescription in the community at nhs expense).

Eligibility criteria:
inclusion criteria: * adult patients (≥18 years) who are able to communicate their views regarding acceptability. * patients established on an oral nutritional supplement, being prescribed 1-2 ons providing approximately 300kcal/day * patients expected to require oral nutritional supplementation for at least 2 further weeks. * informed consent obtained. exclusion criteria: * participation in any other studies involving investigational or marketed products concomitantly or within two weeks prior to entry into the study * patients requiring a milk-free diet * patients with medical or dietary contraindication to any feed ingredients (see appendix 2 of protocol for full list) * patients with significant renal or hepatic impairment * patients with swallowing impairment requiring thickened fluids * patients with inflammatory bowel disease or previous bowel resection.
environmental influences on vitamin d status

Conditions: Vitamin D Deficiency

Summary: vitamin d deficiency is a common problem. the principal source of vitamin d for humans is solar exposure, with cutaneous synthesis of vitamin d by photoconversion of 7-dehydrocholesterol in the skin to pre-vitamin d3. latitude, altitude, season, skin pigmentation, and age are recognized factors that influence how much vitamin d can be made by solar exposure. however, the relative influences of each are largely unknown and we cannot reliably answer the question of how much sun exposure an individual needs at various latitudes and at various seasons in order to ensure normal vitamin d status.

purpose of the study: to determine the effect of environmental influences on vitamin d status. specific aims 1. to measure the prevailing 25d and vitamin d levels in communities at diverse latitudes (alaska and hawaii). 2. to collect information on variables that influence vitamin d status such as skin color, history of sun exposure and sunscreen use, diet history, vitamin and calcium supplements used, and bmi. 3. to collect typical food samples from the region for future analysis of their vitamin d and 25d content. 4. to collect a blood sample for dna analysis of inter-individual differences in vitamin d metabolism (gc or vitamin d binding protein alleles).

Eligibility criteria:
inclusion criteria: * able to consent and come for a study visit. male or female males and females ages 18-60. exclusion criteria: * unable to consent or come to a visit, taking vitamin d supplements, anticonvulsants, barbiturates, steroids, having granulomatous disease, or liver or kidney disease as these medications and conditions interfere with vitamin d metabolism.

Keywords: vitamin d sun latitude vitamin d status