Kornimate/medical-research-clean huggingface dataset:
wear measurement of opposing enamel to milled resin matrix ceramic versus bulk fill resin composite after 2 years

Conditions: Dental Wear

Summary: this clinical trial conducted to measure the amount of wear of opposing enamel to indirect milled resin matrix ceramic versus direct bulk fill resin composite intraorally using digital scanner after two years of using

indirect milled resin matrix ceramic overlay versus direct bulk fill resin composite overlay was utilized in a clinical trial to compare the amount of enamel wear on endodontically treated molars using a panda p2 digital scanner and geomagic control x 3d software. after one and two years, measurements of enamel wear were taken.

Eligibility criteria:
inclusion criteria: * ● patients with non vital badly decayed posterior teeth. * 18 -55years. * males or females. * good oral hygiene. * co-operative patients approving to participate in the study exclusion criteria: * high caries index. * severe medical complications. * pregnancy. * allergic history concerning methacrylates disabilities. * heavy smoking. * xerostomia. * lack of compliance. * evidence of parafunctional habits. * temporomandibular joint disorders.

Keywords: wear measurements, resin matrix ceramic, bulk fill composite, digital scanner.
fmri study examining effects of d-cycloserine in specific phobia

Conditions: Phobias

Summary: the research team hopes to use brain imaging and mental testing to learn more about specific phobias and the treatment of phobia. when given directly prior to therapy sessions, d-cycloserine has been shown to enhance the effects of therapy. this study hopes to identify reasons why d-cycloserine has this effect by measuring brain activity.

exposure and response prevention (erp) therapy has become the treatment of choice for specific phobias. erp involves systematic and repeated exposure to a feared or anxiety-provoking stimulus, leading to habituation and extinction of the fear response. animal models of fear extinction have shown that acute administration of d-cycloserine (dcs) prior to exposure to a feared stimulus enhances extinction of that fear. a recent study in human subjects with height phobia (a specific phobia) has also demonstrated that dcs facilitates the effects of erp therapy. current theories postulate that dcs facilitates fear extinction by enhancing the learning process and increasing consolidation of memories, but the neural mechanisms underlying this process are not understood. the proposed research aims to elucidate these mechanisms by using fmri to measure brain activation during 1) symptom provocation and verbal learning two hours post-medication, and 2)repeated symptom provocation and verbal recognition one week post-medication. this research will also examine the effects of dcs on cognitive functioning using neuropsychological testing both two house and one week post-medication.

Eligibility criteria:
inclusion criteria: * right-handed * adults between 18 and 55 years of age * subjects in the phobic group will additionally meet diagnostic (dsm-iv) criteria for spider phobia. * individuals of both genders and all races will be included exclusion criteria: * women who are breastfeeding or pregnant * individuals with medical conditions unsuitable for mr scanning * individuals reporting a history of epilepsy or seizures * individuals reporting an allergy to cycloserine * individuals diagnosed with asthma or who report previous anaphylactic reaction to insect stings/bites, medication, food, or other material and/or event * individuals reporting present or past diagnosis of a developmental disorder, neurological disorder, or head injury \*individuals found to have axis i psychopathology as defined by the dsm-iv (other than spider phobia) * individuals currently taking any psychotropic medication
a study of luffa operculate nasal solution 5mg/ml compared with saline (nacl 09%) for the relief of nasal obstruction

Conditions: Rhinitis; Sinusitis

Summary: sixty subjects will take part in this study. the subjects will be randomly assigned in a 1:1 ratio between the two arms of study. (group a: solution of luffa nasal operculate 5mg/ml, group b: saline). the subjects will use the study medication or comparative, according to their randomization, for a treatment period of 3 to 7 days. a follow-up visit will be made 15 days after initiation of treatment.


Eligibility criteria:
inclusion criteria: * subjects of both sexes aged over 18 years. * presence of nasal congestion due to colds, rhinitis, influenza, sinusitis and acute or chronic sinusitis * sign the informed consent form * comply the study requirements and attend to study visits * female subjects must have a negative urine pregnancy test during the screening. exclusion criteria: * known allergy to any study product component * subject pregnant, lactating or of childbearing potential and not using adequate and effective contraceptive * vasoconstrictor nasal topic or oral * use of a decongestant nasal whatever the route of administration * use of intranasal corticosteroids * use of antiallergic * use of medication containing atropine * subjects that are participating in another study or who participated in another study, less than 12 months * any subjects deemed unsuitable for study by the principal investigator * abuse of alcohol or illicit drugs
management of diabetes mellitus patients with retinopathy

Conditions: Retinopathy; Diabetes Mellitus

Summary: aim of this nis is to retrospectively document the management of diabetic patients with retinopathy in a naturalistic setting in switzerland. following elements are going to be analyzed: * which medication are used to keep blood pressure under control? * which medication are used for metabolic control? * the average control level of metabolism and blood pressure is compliant with the international guidelines? * laser photocoagulation plays a role in the control of metabolism and blood pressure? * there are differences in the control of metabolism and blood pressure between patients with dm i or dm ii? * there is an influence of renal failure on the choose of medication?


Eligibility criteria:
inclusion criteria: * diabetic patients * diabetic retinopathy

Keywords: diabetes mellitus retinopathy management of diabetic patients with retinopathy
characterization and prediction of atrial fibrillation-caused adverse events after hospital discharge for cardiac surgery

Conditions: Atrial Fibrillation; Stroke, Acute; Death

Summary: the purpose of the research is to identify the frequency and severity of adverse events related to atrial fibrillation that occur after discharge from hospital where the patient underwent cardiac surgery. the specific aims of the proposed study are to: 1. identify the predictors of postoperative atrial fibrillation after discharge from hospital. 2. identify the frequency of readmission to hospital, or other resource use such as emergency department or outpatient visit, for the treatment or prophylaxis of postoperative af and consequent stroke or bleeding outcomes. 3. identify the risks for stroke, death and other morbidity in patients after cardiac surgery and the effect of postoperative af upon subsequent stroke or bleeding outcomes.


Eligibility criteria:
inclusion criteria: * patients who underwent cardiac surgery in massachusetts between 2012 - 2016 exclusion criteria: * surgical procedures that do not include coronary artery bypass graft surgery, aortic valve surgery or mitral valve surgery; * surgical procedures that include maze surgery, or pulmonary vein isolation, ventricular assist device, heart transplantation, congenital heart surgery, bacterial endocarditis, cardiac trauma, cardiac tumor, ventricular septal defect repair, left ventricular aneurysm repair, pulmonary thromboendarterectomy, sub-aortic stenosis resection or surgical ventricular restoration; * surgical procedures on patients that have undergone maze surgery, af ablation procedures, pulmonary vein isolation or left atrial appendage resection or ablation (such as watchman devices).
evaluating pain and discomfort associated with cervical punch biopsy

Conditions: Pain; Anxiety

Summary: the use of forced coughing during cervical punch biopsy may reduce pain \& discomfort associated with the procedure.

pain and anxiety are associated with many medical procedures performed in ambulatory setting. colposcopically guided punch biopsies are a standard procedure performed in women with abnormal cervical cytology, as a part of the diagnosis and treatment selection. coughing is thought to provide a distraction and to cause a momentarily increase in blood pressure, reducing pain perception. therefore, the present study is designed to compare pain associated with cervical punch biopsy and the effect of forced coughing on pain and pain perception.

Eligibility criteria:
inclusion criteria: - women undergoing cervical punch biopsy exclusion criteria: * women under 18 years old * women currently taking prescription pain medications * women who consumed pain medication up to 2 hours prior to the scheduled biopsy. * women who refuse to take part in the study

Keywords: cervical biopsy forced cough pain vas scale
pinpointing the factors affecting clinical trial experiences of glioblastoma patients

Conditions: Glioblastoma

Summary: historically, clinical study participation has been biased toward certain demographics. however, there is a shortage of studies that delve into the underlying factors that influence patient participation, both positively and negatively. several people will be invited to enroll in this study so that it may collect a variety of data about glioblastoma clinical trial experiences and identify barriers to participation as well as the causes of participants' failure or withdrawal. the data collected from this study will be analyzed and used to improve the experiences of future glioblastoma patients who are recruited for medical trials.


Eligibility criteria:
inclusion criteria: * patient has self-identified as planning to enroll in a clinical trial * patient has been diagnosed with glioblastoma * patient is a minimum of 18 years or older exclusion criteria: * patient does not understand, sign, and return consent form * inability to perform regular electronic reporting * patient is pregnant

Keywords: glioblastoma
myo-kinetic stretching versus post-isometrics relaxation exercise with traction in patients of cervical radiculopathy

Conditions: Cervical Radiculopathy

Summary: the goal of this clinical trial is to examine the effectiveness of myo-kinetic stretching exercises versus post-isometric relaxation exercise in patients with cervical radiculopathy. convenient sampling technique will be used to enroll the patients. patients will be screened on the basis of pre formulated eligibility criteria. written consent will be taken from each patient for participation in the trial. the calculated sample size of this study will be 68 calculated through epitool. group a will receive conservative baseline treatment consisted of hot pack therapy for 10 minutes and traction for 8 minutes. myo-kinetic stretching exercises and group b will receive conservative baseline treatment and post-isometric relaxation exercise. the assessment of patients will be done at baseline, 4th and 8th week. the outcomes from patients will be calculated by using numeric pain rating scale (nprs), goniometer and neck disability index. the comparison between pre-treatment and post-treatment data will be done after 8th week. data will be analyzed through spss 25.


Eligibility criteria:
inclusion criteria: * duration of cervical pain more than 4 weeks. * history of positive spurling test exclusion criteria: * history of previous cervical surgery * cervical spine tumor. * rheumatoid arthritis, prolong steroid use and osteoporosis in cervical region. * cervical spine fracture.
treatment recommendations for gastrointestinal cancers via large language models

Conditions: Gastrointestinal Neoplasm Malignant

Summary: this study will evaluate the utility of chatgpt in recommending treatment plans for patients with gastrointestinal cancers, using both retrospective and prospective data.

the medical records of over 1,200 patients with gastrointestinal cancers will be collected retrospectively from participating hospitals. this data will be split into an exploratory dataset (n=200) and a validation dataset (n\>=1,000). within the exploratory dataset, various prompt methods will be used to determine the treatment plans suggested by chatgpt. additionally, several clinicians of varied seniority levels will provide their treatment recommendations. for the validation dataset, chatgpt's suggestions for treatment plans will undergo both qualitative and quantitative assessments by a multidisciplinary consultation (mdt) team. the recommendations from chatgpt will then be compared with those from the clinicians. furthermore, this study will incorporate a prospective dataset comprising 400 participants with gastrointestinal cancers. the participants will be randomly allocated to either a control group (n=200) or a chatgpt-assisted group (n=200). in the control group, treatment plan recommendations will solely be provided by the clinicians and will guide subsequent treatments. in the chatgpt-assisted group, initial treatment plan recommendations will be independently proposed by both chatgpt and the clinicians. based on chatgpt's suggestions, clinicians might selectively adjust their initial plans. participants will then receive treatments as per these refined plans. within the chatgpt-assisted group, the treatment plans of the initial 100 participants will be evaluated to determine the percentage of patients whose treatment plans are influenced by chatgpt. subsequently, the proportion of participants in the entire chatgpt-assisted group with treatment plans modified by chatgpt will be calculated. the study will further monitor the 3-year progression-free survival (pfs) and the 5-year overall survival (os) rates, contrasting the outcomes between the control and chatgpt-assisted groups.

Eligibility criteria:
inclusion criteria: * age ≥18 years, both male and female. * pathologically confirmed diagnosis of gastrointestinal cancer (gastric cancer or colorectal cancer). * detailed medical records available prior to treatment (including chief complaint, history of present illness, radiological examinations, pathological examinations, laboratory tests, etc.). * participants will receive complete treatment in the participating hospitals. exclusion criteria: * participants with cancers other than gastrointestinal cancers. * participants who receive treatment in multiple hospitals.

Keywords: artificial intelligence large language model gastrointestinal cancers treatment recommendation
implantable loop recorders in post-atrial fibrillation (af) ablation: rpaf-a

Conditions: Atrial Fibrillation

Summary: this is a randomized pilot study, of post pulmonary vein isolation (pvi) patients to determine the clinical utility of the implantable loop recorder. these type of patients either are monitored with weekly transtelephonic monitoring (ttm) or implantable loop recorder (ilr). the medtronic reveal xt loop recorder will be implanted at the time of the pvi or at the 3-4 month pvi follow-up visit and patient care will be managed based on randomization to a blinded or unblinded group. outcome measures will be compared to aid in decision making regarding anticoagulation and overall post ablation clinical management.

this is a randomized pilot study, of post pulmonary vein isolation (pvi) patients to determine the clinical utility of the implantable loop recorder. the medtronic reveal xt implantable loop recorder is a market released device indicated for patients with clinical syndromes or situations at increased risk of cardiac arrhythmias, and patients who experience transient symptoms that may suggest a cardiac arrhythmia. these type of patients either are monitored with weekly transtelephonic monitoring (ttm) or implantable loop recorder (ilr). neither approach has been shown to be superior. as both approaches are currently being performed based on physician preference, the investigators propose to study and compare both approaches in a randomized fashion for evidence based practice. the medtronic reveal xt loop recorder will be implanted at the time of the pvi or at the 3-4 month pvi follow-up visit and patient care will be managed based on randomization to a blinded or unblinded group. outcome measures will be compared to aid in decision making regarding anticoagulation and overall post ablation clinical management.

Eligibility criteria:
inclusion criteria: * atrial fibrillation * chads score \> or equal to 1 exclusion criteria: * contraindication for ilr * life expectancy less an 12 months * pregnant women * existing cardiac rhythm management (crm) device

Keywords: atrial fibrillation implantable loop recorder ttm
renal metabolism of glycolate to oxalate

Conditions: Healthy

Summary: this study will determine the contribution of glycolate metabolism to urinary oxalate excretion in healthy subjects, using carbon 13 isotope glycolate tracer technique and a low-oxalate controlled diet.

it is known that glycolate, an intermediary molecule in normal metabolism, can be converted into oxalate. the origin of urinary oxalate is of interest as calcium oxalate is a main component of kidney stones. in the rare disease primary hyperoxaluria, excessive production of oxalate by the body results in frequent kidney stones and can cause loss of kidney function. primary hyperoxaluria is caused by deficiencies in one of several enzymes involved in the glycolate pathway. this study will seek to determine how much oxalate is formed from glycolate in normal subjects. after consuming a controlled diet, subjects will either ingest or have an intravenous infusion of carbon 13 glycolate, a stable isotope of glycolate that can be tracked and will also label downstream metabolic products. blood and urine samples will be assessed for their amounts of labeled glycolate and labeled oxalate to provide an accurate measure of how much oxalate is made from normal glycolate breakdown in healthy human subjects.

Eligibility criteria:
inclusion criteria: * mentally competent adults, able to read and comprehend the consent form * 18-75 years of age * body mass index (bmi) between 19 and 40 * in good health as judged from a medical history, reported medications, and a complete blood metabolic profile * acceptable 24 hour urine collections (performed twice for screening) exclusion criteria: * history of any hepatic, renal, bowel, or endocrine disease or any other condition that may influence the absorption, transport or urine excretion of ions * abnormal urine chemistries or blood metabolic profiles * poor 24 hour urine collections completed during screening, judged by 24 hour urine creatinine excretion (indicative of not collecting all urine in the 24 hour period) * pregnancy, intention to become pregnant in the near future, or lactation * aged \ 75 * bmi \ 40

Keywords: oxalate metabolism kidney stones glycolate isotope tracer study urolithiasis oxalate
the impact of remimazolam for postoperative sedation on the left ventricular systolic performance in cardiac surgery

Conditions: Coronary Artery Disease

Summary: this study analyzes the impact of intraoperative remimazolam infusion for postoperative sedation on the left ventricular global longitude strain (lv-gls) patients undergoing cardiac surgery


Eligibility criteria:
inclusion criteria: * elective off-pump coronary artery bypass surgery exclusion criteria: * arrhythmia * lv ejection fraction \< 50 % * preoperative inotropic support
paced-digitized support during adjuvant endocrine therapy

Conditions: Breast Cancer; Treatment Adherence; Quality of Life; Treatment Side Effects

Summary: the research team want to investigate whether digital support, an app under preventive hormonal breast cancer treatment can lead to less late side effects, better quality of life and increased adherence to treatment.

patients with hormon receptor positive breast cancer and adjuvant endocrine treatment will be invited to participate in the study after adjuvant radiotherapy is completed. participants will be randomised to 12 months of access to a digital support-an app-in addition to standard follow-up or standard follow-up. research team want to investigate whether digital support under hormonal breast cancer treatment can lead to less late side effects, better quality of life and increased adherence to treatment.

Eligibility criteria:
inclusion criteria: * hormone receptor positive breast cancer * on adjuvant endocrine treatment 0-16 weeks ago exclusion criteria: * cognitively impaired * no access to a mobile phone or internet * not understanding swedish

Keywords: digital support
biochip for hcmv detection in breast milk

Conditions: Cytomegalovirus Infections; Breast Feeding; Premature Birth of Newborn

Summary: human cytomegalovirus (hcmv) is the leading cause of neonatal viral infection and can have a significant impact on the neurosensory development of newborns and especially preterm infants. hcmv infection may result from maternal-fetal transmission during pregnancy or postnatal transmission. while congenital hcmv infection affects about 2-5% of very preterm infants, the risk of postnatal infection, particularly through breast milk, is much higher in this population (prevalence of about 20%). many learned societies wonder about the interest to inactivate hcmv (by freezing or pasteurization) in breast milk in order to reduce or eliminate contamination of these children. however, freezing is relatively inefficient to reduce contamination and pasteurization drastically alters the nutritional quality of the milk. therefore, a systematic preventive treatment of breast milk for very preterm infants is not currently recommended. an alternative approach could consist in detecting hcmv in breast milk to target at-risk situations. this detection can be performed by pcr but its cost and the time required to obtain the result prohibits its use for a mass detection. currently, viral status of breast milk is not explored in practice and, depending on the health centers, breastfeeding is continued as such or milk is systematically inactivated.the main objective of virumilk is to study the feasibility of the cmv detection in breast milk from lactating mothers with a biochip.the ultimate goal is to prevent postnatal hcmv infection of preterm newborns less than 33 weeks.


Eligibility criteria:
inclusion criteria: * lactating women (\> 18 years) * mothers with infants less than 33 weeks hospitalized in intensive care infant / neonatal the university hospital of besancon. * no opposition mothers. * join a french social security or receiving such a scheme. * subjects who received medical care during pregnancy. exclusion criteria: * legal incapacity or limited legal capacity. * topics without health insurance. * topics being in the disqualification of another study or under the "national register of volunteers."