Kornimate/medical-research-clean huggingface dataset:
effects of home-based cimt and clinic-based cim on stroke

Conditions: Motor Function

Summary: constraint induced movement therapy (cimt) is based on the theoretical basis that constraining the unaffected limb following injury of the brain such as stroke can help overcome learned non-use. it comprises of constraint of the unaffected limb, massed tasks practice with the affected limb and a behavioral contract known as the transfer package whereby use of the affected limb is extended to the real-world situations. home-based rehabilitation is likely to be cost-effective, and it may reduce cost for patients in terms of hospital charges and transport fares. however, one of the major problems with the existing home-based cimt protocols is that, they used number of hours spent carrying out tasks practice as the measure of intensity of practice, and it has been argued that, such method is not clear and it does not reflect the correct intensity of practice.

the aim of this study is to determine the effects of home-based cimt compared with clinic-based cimt that use number of repetition of tasks practice on motor impairment, motor function, quantity and quality of use of the limb in everyday life, community integration, stroke self-efficacy and quality of life. constraint induced movement therapy (cimt) can be administered either at home or in the clinic. the home-based cimt is used to make cimt easier for the patients

Eligibility criteria:
inclusion criteria: * have stroke 1-2 years before * moderate disability * a score of 1 to 3 on the motor arm item of the national institutes of health stroke scale (nihss) * a score of 3 or more on the upper arm item of the motor assessment scale (mas) * no significant cognitive impairment (a score of ≥24 points on minimental state examination) exclusion criteria: * patients with re-stroke * serious orthopaedic conditions such joint contracture, osteoarthritis and burns that will interfere with carrying out cimt * who are receiving rehabilitation at the time of the study

Keywords: constraint induced movement therapy disability
preventing urinary tract infections with e. coli nissle:

Conditions: Urinary Tract Infections in Children; Secondary Prevention

Summary: urinary tract infections (utis) account for 5-14% of pediatric emergency department visits annually. at the moment, up to one third of children suffering of acute (uti) will have a new infection and there is a lack of effective methods for preventing secondary utis in young children. majority of utis in children are caused by intestinal bacteria of the patient, mainly e. coli that colonizes gut of the patient. e. coli nissle is a probiotic strain that has been used successfully for treating acute gastrointestinal infections in children. the strain has also been proved to be safe for infants and young children. e. coli nissle could be a potential solution for preventing recurrent urinary tract infections in children as it competes with pathogenic bacteria that usually cause utis in children. the aim of this study is to evaluate efficacy of e. coli nissle strain in secondary prevention of urinary tract infections in young children.

in order to asses efficacy of e. coli nissle strain in prevention of recurrent utis in children, we aim to conduct randomized, placebo controlled and double blinded clinical trial. we are going to recruit children who are suffering the first urinary tract infection of their life. the uti will be treated by normal clinical recommendations decided by treating physician. intervention will start on the day following the last day of the antimicrobial course. the intervention will last for 15 days and the study participants will receive either intervention drug or placebo. intervention drug contains 10 e8 cfu/ml of e. coli nissle strain and will be administered as dose of 1 ml of oral suspension once daily for children aged under one year and twice daily for children aged more than one year. the study patients will be monitored by monthly electronic surveys for six months after the intervention in order to measure proportion of the children who will have a new uti during the follow up. we are also going to record possible adverse effects in both study groups. also use of antimicrobial medication due to any reason will be recorded.

Eligibility criteria:
inclusion criteria: * children who suffer of the first urinary tract infection of their life defined as pyuria, presence of symptoms (fever or focal symptom), no other explanation for infection, bacterial culture positive or culture result pending * written informed consent exclusion criteria: * preterm birth, gestational age less than 35 weeks * signs of life-threatening infection (such as meningitis) * detected anomaly in urinary tract * primary immunodeficiency * detected anomaly of ge tract * ongoing antimicrobial prophylaxis * hospital-acquired infection

Keywords: urinary tract infections e. coli
the role of breast milk neutrophils from mothers with metabolic diseases after nutritional intervention. impact on infant development and response to pulmonary infections

Conditions: Gestational Diabetes Mellitus (GDM)

Summary: this project aims at identifying variations in breast milk neutrophils among lactating mothers with gestational diabetes or obesity (objective 1), and to describe how a dietary intervention with omega-3 fatty acids affects these changes (objective 2). the occurrence of respiratory infections on the progeny will be analysed, as well as its development and the impact on gut microbiota and epigenetic changes (objective 3). the involvement of breast milk on the neonate's microbiota (sub-objective 1) and epigenetic variations (sub-objective 2) will be depicted. in addition, the direct engagement of milk neutrophils in the ability of the progeny to react against lung infections will be studied (sub-objective 3). to attain these mother milk and blood samples will be obtained from three groups of lactating mothers: control, obesity or gestational diabetes, upon a dietary intervention with omega-3 fatty acids. neutrophil populations of maternal blood and milk samples will be studied by flow cytometry and in vitro assays. the microbiome and mirna content of infant's saliva and tool samples will be characterized by 16s rrna gene sequencing and pcr. the occurrence of respiratory infections and the development the infants participating in the study will be tracked during the first 2 years of life by telephone surveys. to study the impact of the presented maternal variables on the progeny upon a respiratory inflammation on a systemic level, mouse models will be employed. the offspring of lactating dams with gestational diabetes or obesity will be subjected to an artificial acute lung infection. the progression of the lung disease will be studied by histology and the neutrophil profile in the organs of the litter by flow cytometry. the response to acute lung injury after fecal transplantation with infant's microbiota intro germ-free mice as well as of wild type pups breastfeed by neutropenic dams will complement the animal studies.


Eligibility criteria:
inclusion criteria: * full term pregnancy (\>37 weeks) * mother age 18-50 years * intention to practice exclusive breastfeeding for at least 3 months exclusion criteria: * preterm pregnancy (\<37 weeks) * multiple delivery * delivery complications that compromise the well-being of the newborn * congenital abnormalities of the baby * pathologies of the mother such as hypertension, hellp syndrome, thyroids alterations or nephropathies - drugs or alcohol abuse record * occurrence of mastitis during the study * mothers practicing tandem nursing
tai chi for patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study was to study the impact of tai chi group exercise on physical function, health and disease activity of patients with ra, and to examine the patients' experience and perception of tai chi.

rheumatoid arthritis (ra) is a chronic, inflammatory and systemic disease that mainly affects the musculoskeletal system. the disease is often progressive and may result in reduced physical function, pain, fatigue, and joint destruction. exercise programs are reported to improve physical functioning in patients with ra. tai chi is a traditional chinese martial art that was developed in the 13th century, and combines slow and gentle movements with mental focus. the aim of this study was to examine the impact of a 12 weeks standardized tai chi group exercise program on disease activity, physical function and health status in patients with ra attending. further, the patients experiences of possible effects of tai chi were to be obtained in a focus group interview.

Eligibility criteria:
inclusion criteria: * diagnosis of ra according to the american college of rheumatology (acr) 1987 * stable medical treatment * no earlier experience with tai chi exclusion criteria: * lack of ability to bear weight on the lower extremities * recent or ongoing disease flare * unstable heart condition * participation in other physical exercise interventions more than twice a week included in other intervention studies.

Keywords: exercise physical function rheumatoid arthritis tai chi
social connections and healthy aging (the senior connection)

Conditions: Suicidal Ideation; Depression

Summary: this randomized trial compares peer companionship to care-as-usual in primary care on the outcome of risk for suicidal behavior in late life. the investigators hypothesize that older adults assigned to receive peer companionship will report greater social connectedness and less death and suicidal ideation compared to older adults assigned to care as usual.

there is a pressing need for interventions that reduce risk for suicide in later life. older adults in the u.s. have the highest rate of suicide and are the fastest growing segment of the population. the investigators can anticipate a large rise in the number of older adults who die by suicide in coming decades. this application is in response to rfa-ce-10-006. consistent with the cdc's key strategy of reducing suicide by promoting connectedness, our long-term goal is to reduce late life suicide-related morbidity and mortality by leveraging the resources and expertise of the aging services provider network (aspn) to address unmet social needs of community-dwelling older adults. our objectives with this proposal are (1) to examine whether linking socially disconnected seniors with peer supports through the retired and senior volunteer program (rsvp) is effective in reducing risk for suicide, and (2) to test an hypothesized mechanism for the association of social disconnectedness and suicidal ideation and behavior informed by the interpersonal theory of suicide. the investigators will recruit 400 primary care patients (200 men and 200 women) over age 60 years who endorse feeling lonely and/or as if they are a burden on others. they will be randomly assigned to either of two conditions. those assigned to the senior connection (tsc) will either be paired with a peer companion or, if they prefer and are eligible, be trained and placed as a peer companion for others by rsvp. the comparison group will receive no further intervention ("care-as-usual" \[cau\]). subjects will be followed for up to 24 months with repeated in-home (baseline, 12, and 24 months) and telephone assessments (3, 6, and 18 months).

Eligibility criteria:
inclusion criteria: * age 60 or older * primary care patient * endorses feeling lonely and/or like a burden in the the past two weeks exclusion criteria: * positive dementia screen * current alcohol abuse * psychosis * suicidal ideation with intent to act (current or past month.)

Keywords: suicidal ideation loneliness social support voluntary workers friends/companions prevention aged
il-39 & il-35 gingival crevicular fluid levels in diabetic patients with generalized periodontitis

Conditions: Generalized Periodontal Disease, AVDC Stage 3

Summary: the sudy was aiming to assess and compare gcf levels of il-39 \& il-35 in gingival crevicular fluid and to correlate the relationship between different patient groups before and after non-surgical therapy.

methodology: group i (periodontitis group): 19 patients suffering from generalized periodontitis with t2dm age range, 35-50 years. group ii (periodontitis group): 19 patients suffering from generalized periodontitis \& systemically healthy, age range: 35-50 years. group iii (control group): 19 periodontally and systemically healthy volunteers who served as control subjects age range: 30-45 years. periodontitis participants will be collected from the outpatient clinic of oral medicine and periodontology departments in fayoum, beni-swief and ahram-candian universities. the periodontitis included subjects will be diagnosed according to the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions (tonetti, ms, greenwell, h, kornman, ks. staging and grading of periodontitis: framework and proposal of a new classification and case definition. j periodontol.; 89( suppl 1): s159- s172, 2018.) diabetic patients will be enrolled in this study according to the criteria of american diabetes association. (american diabetes association. (2) classification and diagnosis of diabetes. diabetes care 38: s8-s16, 2015.) the control group will be selected from healthy subjects who attended the restorative dental clinic and has apparently clinically healthy gingiva. micropipettes will be used for collection of gcf samples for control group and periodontitis patients before \& after periodontal treatment. a complete mouth non-surgical periodontal therapy will be carried out for both periodontitis groups the levels of il-35 in the gcf samples were assessed using an elisa kit following the guidelines by the manufacturer.

Eligibility criteria:
inclusion criteria stage iii grade c generalized periodontitis with diabetes stage iii grade b generalized periodontitis in systemic healthy subjects exclusion criteria: 1. patients treated with any type of medications and/ or antibiotics during the past 3 months, 2. pregnancy 3. lactation 4. receiving professional periodontal treatment during the past 6 months 5. current or former smokers

Keywords: periodontitis & diabetes mellitus
the use of wireless sensors in neonatal intensive care

Conditions: Preterm Birth; Apnea of Newborn

Summary: the study will be conducted in a convenience sample of 75 infants admitted to the nicu at the montreal children's hospital, divided into 3 phases: (a) phase 1a - monitoring for 8h per day for 4 consecutive days, (b) phase 1b - monitoring between 2h to 8h per day for 2 to 4 consecutive days, and (c) phase 2- monitoring for 96h continuously. study objectives include: 1. demonstrate the feasibility of continuous wireless monitoring in term and preterm infants with variable degrees of maturation and acuity in the nicu. 2. assess safety of using a special wireless sensor system in neonates. 3. evaluate the accuracy of proposed wireless technology as compared to standard monitoring technology in the nicu.

infants admitted in the nicu are all subject to continuous monitoring of vital signs such as heart rate, respirations and oxygen saturation (spo2) by placing sensors, leads, or bands directly on infant's skin and connecting them to monitors via wires. however, despite the rapid technological advances in wireless monitoring and wearable devices across various industries, the health care sector has traditionally lagged. therefore, the investigators aim to explore the safety and effectiveness of wireless monitoring (anne™ monitoring system) and compare it with the traditional wired monitoring system on infants with variable degrees of maturity in the nicu. more specifically, the investigators aim to examine (1) if it is feasible and to implement a wireless monitoring system in both term and preterm infants in the nicu; (2) if it is safe to use this particular wireless monitoring system among neonates; and (3) the accuracy of the wireless monitoring technology compared to the stand-of-care monitoring in the nicu.

Eligibility criteria:
inclusion criteria: * healthy term infants in room air at enrollment * term infants with perinatal asphyxia undergoing therapeutic hypothermia at enrollment * healthy preterm infants in room air at enrollment * preterm infants on continuous positive airway pressure at enrollment * preterm infants on conventional mechanical ventilation at enrollment * preterm infants on high frequency ventilation at enrollment * preterm infants on nasal intermittent positive end expiratory pressure at enrollment * preterm infants on continuous positive airway pressure at enrollment exclusion criteria: * congenital anomalies and surgical conditions (ex: gastroschisis, omphalocele, congenital diaphragmatic hernia) * congenital heart disorders * congenital skin infections or known conditions with fragile skin (such as epidermolysis bullosa)

Keywords: continuous monitoring nicu wireless sensors
hemodynamic and biological evaluations during reventilation collapse in icu

Conditions: Arterial Line; Consent of Patients; Adult Patients; Tracheal Intubation in ICU

Summary: prospective, observational clinical multicentric study in icu; during the period surrounding the orotracheal intubation.

main objective: to describe the characteristics of reventilation collapse: collapse rate, duration and treatment implemented secondary objectives: * identify risk factors of reventilation collapse * compare mortality, hemodynamic, respiratory, infectious and biological data between collapse group and no reventilation collapse group.

Eligibility criteria:
inclusion criteria: * arterial line * consent of patients * adult patients * tracheal intubation in icu exclusion criteria: * tracheal intubation for cardiac arrest * pregnant woman * major protected

Keywords: reventilation collapse rate of reventilation collapse risk factor of reventilation collapse hemodynamic profile of reventilation collapse biologic approach of reventilation collapse
a comparison of fluoxetine and divalproex for the treatment of intermittent explosive disorder

Conditions: Intermittent Explosive Disorder

Summary: this study will compare the medications fluoxetine (prozac®) and divalproex (depakote®) for the treatment of aggressive behavior in individuals with intermittent explosive disorder (ied).

ied is a condition characterized by a failure to resist aggressive impulses. ied is a behavioral defined condition for which effective treatments have not been identified. research suggests that serotonin (5-ht), a chemical that helps regulate mood and emotions, may play a role in the response to pharmacological ied treatments. this study will examine the relationship between 5-ht receptors and response to treatment with fluoxetine or divalproex. in addition, this study will examine people with ied and those without the condition to determine whether there are differences in their 5-ht receptor and transporter systems. participants in this study will be randomly assigned to receive either fluoxetine, divalproex, or placebo for 12 weeks. scale ratings will be used to assess the aggression levels of participants. biologic evaluations of the 5-ht system will be conducted throughout the study.

Eligibility criteria:
inclusion criteria: * diagnosis of intermittent explosive disorder (ied) * in good physical health * overt aggression scale-modified (oas-m) score of 15 or higher at screening * willing and able to comply with the study requirements exclusion criteria: * life history of bipolar disorder, schizophrenia, organic mental syndrome, or mental retardation * current major depressive disorder, with a hamilton depression (ham-d) scale score higher than 18 * current alcohol or drug abuse or dependence * active medical conditions that will interfere with the study * thymoleptic or neuroleptic treatments * presence of the following serious and active medical conditions: demyelinating or progressive degenerative disorders; central nervous system infection; progressive degenerative neurological disorder; ischemic heart disease; respiratory, renal, or liver disease; type i diabetes; malignant neoplasm; hyper- or hypo-coagulopathy; acquired immune deficiency syndrome (aids); or seizure disorder. participants with a history of more than two febrile seizures prior to 1 year of age are eligible. * chronic, ongoing treatment with the following classes of medications: antidepressants, neuroleptics, mood stabilizers, antianxiety agents, hypnotics, narcotics or synthetic narcotics, barbiturates, stimulants, anti-migraine agents, anti-epileptics, non-beta-blocking or ca-channel blocking anti-arrhythmic agents prescribed to treat cardiac arrhythmia, anticoagulants, immunomodulators, anti-neoplastic agents, or hiv antiviral agents * ongoing psychotherapeutic treatment for the treatment of ied or anger that was started less than 3 months before study entry * hypersensitivity to fluoxetine or divalproex * pregnancy
platelet rich fibrin with 1% metformin gel for treatment of intrabony defects

Conditions: Periodontitis

Summary: abstract: background: platelet-rich fibrin (prf) is a second-generation platelet concentrate which releases various growth factors that promote tissue regeneration. metformin (mf), a member of biguanide group has been shown to facilitate osteoblast differentiation and thus may exhibit a favourable effect on alveolar bone . current study was designed to evaluate the combined efficacy of prf and 1% mf gel with open flap debridement (ofd) in treatment of intrabony defects in chronic periodontitis (cp) subjects. methods: one hundred and twenty subjects with single defects were categorized into four treatment groups: ofd alone, ofd with prf, ofd with 1% mf and ofd + prf+1% mf. clinical parameters like site specific plaque index (pi), modified sulcus bleeding index (msbi), probing depth (pd), relative attachment level (ral) and gingival marginal level (gml) were recorded at baseline before surgery and 9 months post-operatively. percentage radiographic intra-bony defect depth reduction was evaluated using computer-aided software at baseline and 9 months.


Eligibility criteria:
inclusion criteria: * presence of 3- wall intrabony defects ≥3 mm deep (distance between alveolar crest and base of the defect on an intraoral periapical radiograph \[iopa\] ) along with an interproximal probing depth (pd) ≥5 mm after phase i therapy (scaling and root planing \[srp\] ) in asymptomatic molar teeth. exclusion criteria: * aggressive periodontitis subjects * subjects with systemic conditions known to affect the periodontal status * medications known to affect the outcomes of periodontal therapy * hematological disorders and insufficient platelet count (\<200,000/mm3) * pregnancy/lactation * smoking and tobacco use in any form * immunocompromised individuals. those having unacceptable oral hygiene (plaque index \[pi\]16 \> 1.5) after re-evaluation of phase i therapy were also excluded from the study. * in addition, teeth with furcation defects, non vital teeth, carious teeth warranting restorations and mobility of at least grade ii were also excluded.

Keywords: periodontal surgery periodontal regeneration growth factors clinical trials