Kornimate/medical-research-clean huggingface dataset:
daylight photodynamic therapy for actinic keratosis and skin field cancerization

Conditions: Actinic Keratosis

Summary: twenty patients with multiple actinic keratosis on the face will be enrolled in the study and will be treated with daylight photodynamic therapy. before and after skin biopsies will be performed, for histological and immunohistochemical analysis.

twenty patients with multiple thin actinic keratosis (ak) on the face will be included in the study. they will be informed of the procedure in detail and sign a consent form. digital photographs will be done in a standardized way. prior to treatment, all patients will undergo 2 skin biopsies under local anesthesia and with a 2 mm punch biopsy. one biopsy will be done over an ak lesion and the other in an area with no apparent ak (field cancerization). the patients will be treated with daylight photodynamic therapy, following these steps: 1. mild curettage of the ak lesions 2. application of a chemical sunscreen with sun protection factor (spf) 30 3. application of methyl aminolevulinate cream (metvix r, galderma laboratories) 4. exposition to daylight, for 120 minutes 5. cleaning of the face three months after treatment, two new skin biopsies will be collected, 1cm away from the initial biopsies. on the same date, new photographs will be made following the same standards as pre-treatment photographs.

Eligibility criteria:
inclusion criteria: -multiple (at least five) actinic keratosis on the face, grades i and ii exclusion criteria: * phototypes iv, v and vi * patients treated for actinic keratosis up to 6 months before * history of allergy to methyl aminolevulinate * history of photoallergy * pregnancy

Keywords: actinic keratosis field cancerization photodynamic therapy daylight photodynamic therapy
impact of suture technique on wound healing in ankle fracture surgery: a randomized controlled trial

Conditions: Ankle Fractures

Summary: our primary aim is to compare the complication rates of patients with ankle fractures who underwent skin closure using a running subcuticular suture pattern compared to an interrupted suture pattern. at the time of the operation, participants will be assigned to either the subcuticular suture group (ssg) or the simple interrupted suture group (sisg) using computer-generated randomization programs. the surgeon will perform the assigned closure technique using standardized techniques. running subcuticular vicryl 3-0 sutures will be placed on patients in the experimental group while simple interrupted monocryl 3-0 sutures patients in our control group. patients will be followed up at the two-week and eight-week postoperative mark where we will use the patient and observer scar assessment scale (posas) to evaluate and compare wound healing. additionally, photographs of the scars will be captured to visually assess the healing progression.


Eligibility criteria:
inclusion criteria: * patients aged 21 years or older with isolated ankle fractures requiring surgical intervention and who consent to participate. exclusion criteria: * patients that will be excluded from this study include those with complex ankle fractures, open fractures, a history of wound healing disorders, and/or those unable to provide consent.
deep learning model and risk factors for tacrolimus-related acute kidney injury

Conditions: AKI

Summary: in this study, the investigators aim to develop a risk prediction model for acute kidney injury (aki) in hospitalized patients using the calcineurin inhibitor tacrolimus. this will be achieved by mining electronic medical record data and employing explainable deep learning methods. the model will provide clinical decision support for timely intervention and treatment. compared to traditional machine learning models, deep neural networks can extract more nuanced features from complex medical data and perform more precise pattern recognition, thereby enhancing prediction accuracy and reliability. by constructing a predictive tool based on explainable deep learning models, the investigators will better assess the association between the use of calcineurin inhibitors and aki, explore targeted prevention strategies, and offer more precise predictions and intervention guidance to clinicians. additionally, this research has significant socio-economic benefits and application potential. by reducing the incidence of aki, the investigators can lower patient hospitalization duration and re-treatment costs, conserve medical resources, and improve patient quality of life. preventive healthcare not only alleviates the physical and psychological burden on patients but also reduces the strain on the healthcare system, enhances healthcare efficiency, and promotes the rational allocation of medical resources.


Eligibility criteria:
inclusion criteria: * use of tacrolimus during hospitalization, with standardized therapeutic drug monitoring * age of 18 years or older at the time of admission * length of hospital stay ≥ hours * at least two serum creatinine level tests conducted during the hospital stay exclusion criteria: * stage 5 chronic kidney disease prior to admission * incomplete clinical data * serum creatinine levels consistently below 40 mmol/l during hospitalization

Keywords: acute kidney injury therapeutic drug monitoring deep learning
formal vs. home-based physical therapy after unicompartmental knee arthroplasty

Conditions: Osteoarthritis

Summary: to determine whether home-based physical therapy (hbpt) is not clinically inferior to formal outpatient physical therapy (opt) after hospital discharge of patients undergoing a unicompartmental knee arthroplasty (uka).

given that current practice trends are requiring treatments to be both clinically and cost effective, research has begun to focus on evaluating the effect of specific interventions. many surgeon and patients have believed formal opt is necessary to optimize functional outcomes following orthopaedic procedures. however, the literature has begun to call into question the need for opt following total hip arthroplasty, total knee arthroplasty, total shoulder arthroplasty, anterior cruciate ligament reconstruction, meniscectomy, and rotator cuff repair. a randomized controlled trial was done to compare face-to-face rehabilitation with in-home telerehabilitation following total knee arthroplasty. utilizing the western ontario and mcmaster universities osteoarthritis index (womac) as the primary outcome, the authors demonstrated noninferiority of telerehabilitation compared to face-to-face rehabilitation. other secondary outcomes of knee injury and osteoarthritis outcome score (koos), range of motion, and isometric strength did not exhibit a difference between the treatment groups. (see citation below) based on these findings, it appears that the high cost of formal opt doesn't translate into a meaningful improvement of functional outcome. because patient's undergoing uka have a higher pre-operative functional status than patients having a tka (total knee arthroplasty), it is reasonable to think that patients following a uka are better equipped to succeed with hbpt. as a result, the hypothesis of the current study is that hbpt will prove to be non-inferior to formal opt in the setting of uka.

Eligibility criteria:
inclusion criteria: * scheduled for a unicompartmental knee arthroplasty exclusion criteria: * require inpatient physical therapy beyond post-operative day one * \< 18 years old * decline to participate

Keywords: home-based physical therapy outpatient physical therapy unicompartmental knee arthroplasty pt (physical therapy) osteoarthritis
the sublingual microcirculatory alterations in patients undergoing extracorporeal flow conditions

Conditions: Microcirculatory Alterations

Summary: the aim of this study is to observe the perioperative course of sublingual microcirculatory alterations in patients undergoing coronary artery bypass grafting (cabg) using cold blood compared with cristalloid cardioplegia. additionally the impact of changes in hemodynamic parameters, blood gas, laboratory findings and standart therapy for intra and early postoperative period was studied. intubation time, icu stay, hospital stay, icu readmission, morbidity and mortality were recorded.

the microcirculatory measurements were obtained in both groups in the sublingual mucosa using cytocam imaging. the probe was handheld. different precautions were taken and steps followed to obtain images of adequate quality and to ensure good reproducibility. images were made after induction of anesthesia (t0), before cbp 5 minutes after heparine (t1), 5 minutes after cbp beginning (t2), during cbp 10 minutes after crossclamp beginning (t3), after crossclamp ending when heart begins to beat (t4), after cbp 10 minutes after protamine (t5). additional images were made before (tc0) and after (tc1) vasoactive medication; before (tv0) and after (tv1) volume administration; before (tb0) and after (tb1) blood administration, (ffp, plt). at each timepoint adequate focus depth and contrast were noticed. three steady images of 6 seconds were acquired and recorded on a device controller based on a powerful medical grade computer which is used for image storage and analysis. additionally macrocirculatory measurements were obtained at the same timepoints. hemodynamic variables, temperature, blood gas, invos, sto2, laboratory findings and standart therapy were recorded. additionally intubation time, icu stay, hospital stay, icu readmission, morbidity and mortality were studied.

Eligibility criteria:
inclusion criteria: * patients undergoing coronary artery bypass grafting (cabg) exclusion criteria: * previous heart and oral surgery * age below 18 years, * emergency surgery * pregnancy

Keywords: microcirculation coronary artery bypass grafting cold blood cardioplegia cristalloid cardioplegia
a big data-based cohort study for cataract patients

Conditions: Cataract; Retina Disorder

Summary: cataract is an important cause of blindness and visual impairment worldwide. at present, the only effective treatment method is surgery. the visual function of most patients can be significantly improved after surgery, but there are still 5-20% of patients whose visual function cannot be improved after surgery. previous studies have found that the surgical complications and postoperative visual function of cataract patients are closely related to the condition of the fundus, but the current fundus camera cannot perform clear fundus imaging of cataract patients, and the existing potential visual inspections, such as retinal visual inspection, are also inaccurate. predict postoperative visual acuity. therefore, there is an urgent need for a reliable postoperative effect prediction system for cataract patients to provide reference for both ophthalmologists and patients. this study intends to collect patient medical record information and traditional/ultra-wide fundus photos and other multi-modal data. firstly, this study will use artificial intelligence technology to enhance fundus photos of cataract patients to obtain clearer fundus photos. then this study will use both medical record information and traditional/ultra-wide fundus photographs to predict postoperative vision and visual function of cataract patients.


Eligibility criteria:
inclusion criteria: * candidates for cataract surgery (phacoemulsification and intraocular lens implantation) within a week. exclusion criteria: * unwilling or unable to receive fundus photography

Keywords: cataract postoperative prediction image enhancement retina disorder
bioequivalency study of clarithromycin tablets under fed conditions

Conditions: Infection

Summary: the objective of this study was the bioequivalence of a potential generic 500 mg clarithromycin tablet formulation compared with abbott laboratories 500 mg clarithromycin tablet, biaxin® following a single 500 mg dose, administered with food.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening. exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. * treatment with known enzyme altering drugs. * history of allergic or adverse response to clarithromycin or any other macrolide antibiotic.
a trial of shr-1701 with or without chemotherapy in patients with stage iii nsclc

Conditions: Non-Small-Cell Lung Cancer

Summary: the study is being conducted to evaluate the efficacy and safety of shr-1701 with or without chemotherapy in the treatment of unresectable stage iii non-small cell lung cancer


Eligibility criteria:
inclusion criteria: * voluntarily participate in the study and sign the informed consent form; * 18 to 70 years old, both male and female; * ecog score: 0-1 * histopathologically or cytologically confirmed, inoperable stage iii squamous cell or non-squamous cell lung cancer; * subjects who can provide fresh or archival tumor tissue; * measurable lesions available; * major organ function is basically normal; * non-surgically sterile female subjects of childbearing age must have a negative serum hcg test before randomization; exclusion criteria: * histologically or cytologically confirmed mixed sclc and nsclc; * subjects who have malignant pleural effusion; * previous systemic anti-tumor therapy for nsclc; * previous thoracic radiotherapy; * subjects who participated in other clinical trials within 4 weeks or 5 drug half-lives(whichever is shorter) before the first dose. * systemic immunostimulant therapy before the first dose; * systemic immunosuppressive therapy before the first dose or were expected to require systemic immunosuppressive drugs during the study treatment; * subjects with autoimmune diseases; * other malignant tumors other than non-small cell lung cancer within 5 years before screening; * known or suspected interstitial pneumonia; * other moderate to severe lung diseases that may interfere with the detection or treatment of drug-related pulmonary toxicity and seriously affect respiratory function; * severe cardiovascular and cerebrovascular diseases; * clinically significant bleeding symptoms or significant bleeding tendency within 1 month before the first dose; * arteriovenous thrombotic events within 3 months before the first dose; * positive hiv test; * active hepatitis b or c; * evidence of active tuberculosis infection within 1 year before the first dose; * serious infection within 4 years before the first dose; * history of attenuated live vaccination 28 days before the first dose or expected to receive attenuated live vaccination during the study; * major surgeries other than diagnosis or biopsy within 28 days prior to first dose; * previous or planned allogeneic bone marrow transplantation or solid organ transplantation; * history of severe allergic reactions to other monoclonal antibodies/fusion proteins; * allergic to any component of the randomized treatment regimen; * female subjects who are pregnant, lactating, or planning to get pregnant during the study period; * subjects who has a known history of psychotropic drug abuse, alcoholism, or drug abuse * presence of other conditions that, in the opinion of the investigator, would make participation in this clinical trial inappropriate.
antibiotic therapy in erupted tooth extractions

Conditions: Tooth Extraction; Post-Op Complication; Amoxicillin

Summary: evaluation of the efficacy of amox+clav and of a probiotic after tooth extraction. the aim is to evaluate efficacy of antibiotic therapy after tooth extractions in preventing infections as compared to no therapy, and efficacy of probiotics in preventing gastro-intestinal adverse effects during the antibiotic treatment. the number of patients to be included is 150. the study products are: amoxicillin + clavulanic acid and bifidobacterium longum and lactoferrin.

the main objective of this trial is to evaluate the efficacy of the antibiotic after tooth extraction in preventing infections and to evaluate the effect of probiotic in reducing the possible antibiotic side effects. in order to analyze the effect of the antibiotic in terms of patient's general discomfort, a tailored form was prepared (appendix a). the local signs and symptoms to evaluate are swelling, pain (assessed by the visual analogic scale), presence of abscess, fever, post-extraction dental alveolitis (dry socket) and presence of trismus assessed as maximal mouth opening variation (mm). in addition adverse post-extraction events will be evaluated as follows: chewing impairments (assessed by the visual analogic scale), speaking impairments (assessed by the visual analogic scale), daily oral hygiene maneuvers impairments (assessed by the visual analogic scale) and daily activities alterations (days-off from job/study). moreover, the patients will be provided with a painkiller's prescription and they are required to take note of the painkillers needed during the first 7 days, i.e. until the first time point recall. the prescribed painkillers will be ibuprofen 600 mg or naproxen sodium 500mg for those patients who reported allergy to ibuprofen. finally, it will be a researcher duty to ask the patients if they needed to assume painkillers beyond the 7th day. since the post-surgical sequelae depend also on the difficulty of extraction, the appendix a provides a table in which the surgeon can take note of the type of extraction.

Eligibility criteria:
inclusion criteria: * patients who needed tooth extractions * patients older than 18 years * patients able to understand and to sign a consent form exclusion criteria: * general contraindications to oral surgery * third molar or impacted tooth extractions * patients treated or under treatment with immunosuppressive agents or patients immunocompromised * patients treated or under therapy with amino-bisphosphonate and anti-angiogenetic intravenous medications * patients who received head and neck irradiation treatments * patients who were diagnosed with uncontrolled diabetes * patients suffering from renal failure * pregnancy and breastfeeding patients * patients diagnosed with drug and alcohol addiction * patients who suffer from psychiatric disorders * patients diagnosed with allergy to penicillin and probiotic

Keywords: tooth extraction antibiotics probiotics tooth infection complications
electrical stimulation vs. static stretching in the leg muscles

Conditions: Muscle Fatigue

Summary: the retraction of the posterior leg muscles consists of a shortening of the muscle fibers that limits ankle dorsiflexion. the objective of this randomized controlled clinical trial (rct) with a double-blind technique and longitudinal chronology is to evaluate the short-term effect of electrostimulation associated with muscle stretching (electrical muscle elongation technique or eme) compared to static stretching in adult subjects with shortening of the posterior leg muscles. the main questions it seeks to answer are: * are there significant differences in the short-term effect of electrical muscle elongation versus static stretching exercises on the gastrocnemius complex and achilles tendon in young adults? * does the ankle\&#39;s range of motion increase in both weight-bearing and non-weight-bearing positions? * does muscle strength increase in ankle plantar flexion? the researchers will compare the group receiving electrical muscle elongation with interferential current to the group receiving passive static stretching to assess whether there are significant differences in the effects on the ankle\&#39;s range of motion and the muscle strength of the posterior leg muscles. participants in this study will perform the following tasks: * receive a session of electrical muscle elongation with tens and static stretching performed by the researcher. * follow the instructions during the intervention. * undergo evaluations of ankle range of motion and plantar flexor muscle strength * record their level of satisfaction after the study.


Eligibility criteria:
inclusion criteria: * subjects affiliated with or related to the university of seville. * those with muscular shortening of the posterior chain of the limb. exclusion criteria: * subjects who engage in sports activity above the average of the sample or who follow an organized stretching program for the posterior leg muscles. * hyperlaxity * history of musculoskeletal, neuromuscular injuries, joint disease, surgery on the lower leg, or serious illness.

Keywords: achilles tendon gastrocnemius muscle electric stimulation static stretching articular range of motion randomized clinical trial longitudinal muscle shortening session duration comparision group electric muscle elongation triceps surae
safety and efficacy of difluprednate 0.05% for the treatment of anterior uveitis

Conditions: Endogenous Anterior Uveitis

Summary: the purpose of this study was to demonstrate that difluprednate 0.05% (durezol) dosed 4 times daily is noninferior to prednisolone 1% (pred forte) dosed 8 times daily for the treatment of endogenous anterior uveitis.


Eligibility criteria:
inclusion criteria: * diagnosis of endogenous anterior uveitis in at least 1 eye. * the presence of \> 10 cells in the anterior chamber of at least one eye, and a flare score of \> 2 in that same eye. * age 2 years or older on day of consent. * negative urine pregnancy test on day 0 for females of childbearing potential who are not at least 1 year post-menopausal or surgically sterilized. * other protocol-defined inclusion criteria may apply. exclusion criteria: * presence of endogenous anterior uveitis diagnosed for \> 2 weeks prior to enrollment in the study. * presence of intermediate uveitis, posterior uveitis or panuveitis in either eye. * instillation of any topical corticosteroid or nsaid in the study eye within 7 days of instillation of study drug. * history of glaucoma or clinically significant ocular hypertension in the opinion of the investigator involving an iop ≥ 21 millimeters mercury in either eye. * history of steroid-induced elevation of intraocular pressure. * any confirmed or suspected active viral, bacterial or fungal keratoconjunctival disease in either eye. * history of glaucoma or clinically significant ocular hypertension in the opinion of the investigator involving an intraocular pressure (iop) \> 21 mmhg in either eye. * corneal abrasion or ulceration in either eye. * pregnancy or lactation. * other protocol-defined exclusion criteria may apply.
collection of blood samples from patients with relapsing ms who developed itp after receiving lemtrada

Conditions: Multiple Sclerosis

Summary: primary objective: to collect blood samples in a new cohort of relapsing forms of multiple sclerosis (rms) participants who had developed immune thrombocytopenic purpura (itp) after lemtrada treatment, for future deoxyribonucleic acid (dna) analysis as part of a global biomarker project assessing pre-identified candidate single nucleotide polymorphisms (snps) associated to the development of itp after lemtrada treatment in rms participants.

one to 70 days, as screening and inclusion visit(s) were performed the same day or on separate days with a maximum timeframe of 30 days apart. one visit was required for blood draw. however, if a second visit occured, it took place within 40 days of the first visit.

Eligibility criteria:
inclusion criteria : * male and female adult participants who had been treated with lemtrada, with development of itp subsequent to treatment. participants does not need to be currently on lemtrada treatment. * participants who had signed the study icf. exclusion criteria: - not applicable the above information was not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.