Kornimate/medical-research-clean huggingface dataset:
crizotinib continuation clinical study

Conditions: NSCLC; ALCL; IMT

Summary: the purpose of this continuation study is to provide continued access to crizotinib treatment for eligible participants from a current pfizer sponsored crizotinib clinical study that is planned to close.

participants not previously enrolled or who have discontinued study treatment or safety follow-up in a current pfizer sponsored crizotinib clinical study are not eligible for participation in this continuation study.

Eligibility criteria:
participants must meet the following key inclusion criteria to be eligible for enrollment into the study: 1. any participant who is receiving crizotinib and deriving clinical benefit (as determined by their doctor) in a crizotinib study which is planned to close. 2. participants must agree to follow the reproductive criteria as outlined in protocol. 3. no ongoing grade ≥3 or intolerable grade 2 aes considered to be related to crizotinib treatment, except for those laboratory eligibility criteria described in inclusion #4. 4. adult participants (≥18 years): adequate hepatic and bone marrow function. stable renal function for at least 14 days. pediatric participants (\<18 years): adequate hepatic and bone marrow function. stable renal function for at least 14 days. exclusion criteria participants with any of the following characteristics/conditions will be excluded: 1. female participants who are pregnant or breastfeeding. 2. any medical reason that, in the opinion of the investigator or sponsor, precludes the participant from inclusion in the study.

Keywords: crizotinib xalkori anaplastic lymphoma kinase alk ros1 nsclc non-small cell lung cancer alcl anaplastic large cell lymphoma imt inflammatory myofibroblastic tumour
predictors of treatment failure among patients with gunshot wounds and post-traumatic stress disorder

Conditions: Gunshot Entry Wound

Summary: the 82.1% treatment failure of post-traumatic stress disorder(ptsd), associated with gunshot wounds, is related to high incidence of chronic pain syndrome as well as resistance to the ptsd treatment. defining treatment failure predictors among the ptsd patients with gunshot extremity wounds and the following therapy would improve treatment outcomes.

it has been noted that the ptsd in military combatants results from their direct participation in military actions. the study revealed that if a military combatant was wounded during the action operation, his emotional and subjective feelings will 100% lead to the ptsd. other scientists state about the ptsd remote treatment failure in 80% of the military combatants. the study evidences about 82.1% of the ptsd m-related wounds treatment failure, which was essential for the subsequent studies. some authors state about treatment effectiveness of psychopharmacological drugs and psychotherapy, which is rather questionable. traumas and somatic diseases in the ptsd patients are known to accumulate their negative effects. so, definition of the ptsd treatment failure predictors may improve treatment outcomes.

Eligibility criteria:
inclusion criteria: * gunshot wounds * post-traumatic stress disorder * patients who need anesthesia exclusion criteria: * the patient has no post-traumatic stress disorder * the patient has no gunshot wounds

Keywords: post-traumatic stress disorder
the impact of the covid-19 pandemic on the patient in need of an intervention

Conditions: Surgical Procedures, Operative; COVID-19; SARS-CoV-2

Summary: mixed-method observational study: the impact of pandemic related changes in healthcare on quality of life and experiences with healthcare in dutch patients undergoing surgery or another intervention during the covid pandemic (2020-2021). phase 1: qualitative study to gain insight in relevant themes in patient reported experiences measures (prems) by conducting focus groups phase 2: creating and validating a questionnaire based on themes identified in phase 1 phase 3: questionnaire study among dutch patients who underwent an intervention in 2020-2021 using the validated questionnaire of phase 2. the answers will be linked to data from national patients registries in surgery, cardiology, orthopedics and neurology.


Eligibility criteria:
inclusion criteria: * undergoing surgery or intervention in the netherlands in 2020 or 2021 exclusion criteria: * participation language restricted to dutch

Keywords: specialties, surgical surgery department, hospital
impacts of a physical therapy protocol on motor function in children with congenital zika syndrome

Conditions: Congenital Zika Syndrome

Summary: the study aims to evaluate the effects of a specialized physiotherapy protocol aimed at the motor function of children with congenital zika virus syndrome. first, participants' anthropometric parameters (weight and length) and motor functions were assessed. after that participant were splited in two groups: experimental group that uunderwent a one-hour daily protocol (5 times a week) of stimuli and handling based on the neuroevolutionary concept, and motor physical therapy with therapeutic garments (pediasuit). on the other hand, the control group (cg) kept the therapeutic routine (conventional physical therapy).


Eligibility criteria:
inclusion criteria: * children with confirmed czs diagnosis by rt-pcr or presumed by imaging findings (ct or mri \[or both\]), and according to the center for disease control and prevention criteria * children accompanied by the support center where the study was conducted. exclusion criteria: * children who did not undergo assessments after the intervention * children those weighing \ 40°\]).
comparison of the postoperative analgesic efficacy of spsipb and espb in anterior cervical discectomy

Conditions: Anterior Cervical Discectomy; Peripheral Nerve Block; Pain Management

Summary: anterior cervical discectomy is an operation performed for complaints of pain, numbness or loss of strength due to cervical disc disease. with this operation, pressure due to herniation on the upper neck area, spinal cord or nerve roots is relieved. it is performed by microscopic method from the front of the neck. nerve blocks reduces opioid consumption in the postoperative period by providing better pain control and therefore has advantages such as fewer side effects and less risk of pulmonary and cardiac complications. in this study; it was aimed to compare the analgesic effectiveness of serratus posterior superior intercostal plane block and erector spinae plane block, with each other and with the control group in the postoperative period in patients who underwent anterior cervical discectomy.


Eligibility criteria:
inclusion criteria: * patients aged 18-80 years * american society of anesthesiologists (asa) score i-ii-iii * body mass index (bmi) between 18-30 kg/m2 exclusion criteria: * patients under 18 and over 80 years of age * asa score iv and above * patients with a history of bleeding diathesis * bmi below 18 or above 30 kg/m2

Keywords: anterior cervical discectomy serratus posterior superior intercostal plane block erector spinae plane block
changes to function and quality of life and patient experience for patients undergoing treatments for recurrent oropharyngeal cancer

Conditions: Recurrent Oropharynx Carcinoma

Summary: the purpose of this research project is to measure changes in communication, swallowing and quality of life and individual patient priorities which may happen over time in patients with a diagnosis of recurrent head and neck cancer, specifically recurrent cancer (cancer which has returned after previous treatment) of the back of the throat, the tonsils and/or the base of tongue (recurrent oropharyngeal cancer) and what it is like for patients and their significant others to experience these changes over time.


Eligibility criteria:
inclusion criteria: * adult (aged 18 years or over) competent to provide consent * have a diagnosis of recurrent opc * have adequate linguistic and cognitive function to participate in interview * english speaking exclusion criteria: * any previous medical condition, other than hnc, which has a known impact on communication/ swallowing (parkinson's disease, multiple sclerosis, cerebral vascular accident (cva)
early follicular supplementation of ganirelix in ivf 2004

Conditions: Infertility; IVF Treatment

Summary: our goal was to investigate whether early follicular supplementation of the gnrh antagonist to the flexible gnrh antagonist protocol, has a potential to improve ivf-et clinical results

gnrh antagonist offers many advantages when used in ivf-et treatment, however, it is suspected to yield lower pregnancy rate when compared with the long gnrh agonist protocol. our goal was to investigate whether early follicular supplementation of the gnrh antagonist to the flexible gnrh antagonist protocol, has a potential to improve ivf-et clinical results. consecutive patients are prospectively enrolled and randomly assigned to the study and control groups. patients with low ovarian reserve or with uterine distortion are excluded from the study. both groups are treated with recombinant fsh and the flexible gnrh antagonist protocol. women in the study group are also treated with additional gnrh antagonist 0.25 mg/day on day 1, 2 and 3 of the menstrual cycle.

Eligibility criteria:
inclusion criteria: * infertility * ivf candidate * failure of previous ivf attempt exclusion criteria: * low ovarian reserve * untreated distortion of uterine cavity * medical contraindication for ivf treatment

Keywords: ivf gnrh antagonist
surgery in treating patients with neuroblastoma

Conditions: Neuroblastoma

Summary: rationale: surgery may be an effective treatment for neuroblastoma. purpose: this phase ii trial is studying how well surgery works in treating patients with neuroblastoma.

objectives: * evaluate the safety and efficacy of surgical treatment alone for stage ii neuroblastoma without n-myc amplification (nma). * describe predictive factors of relapse and survival for stages i and ii neuroblastoma without nma treated by surgery alone. outline: patients with localized resectable tumors undergo surgery. postoperative evaluations are performed 30 days following surgery. study patients with stage i (without n-myc amplification) tumors and trial patients with stage ii tumors receive no further therapy. study patients (except stage i patients) receive surgery and/or chemotherapy according to other protocols as necessary for disease progression or relapse. patients are followed every 3 months for the first year, then every 4 and 6 months for the second and third year respectively, then yearly for 5 years. projected accrual: this study will accrue 140 stage ii patients for the trial portion at a rate of 40 per year over 3.5 years. at least 70 more patients will be accrued for the study portion.

Eligibility criteria:
disease characteristics: * trial: histologically proven international neuroblastoma staging system (inss) stage iia and iib neuroblastoma without amplification of the n-myc oncogene * study: histologically proven neuroblastoma * stage i * stage ii with amplified n-myc * stage ii without evaluation of n-myc * stage ii with symptomatic spinal cord compression * stage iii * no metastases diagnosed within 1 month of study patient characteristics: age: * 20 and under performance status: * not specified life expectancy: * not specified hematopoietic: * not specified hepatic: * not specified renal: * not specified prior concurrent therapy: biologic therapy: * not specified chemotherapy: * no prior chemotherapy * no adjuvant chemotherapy planned endocrine therapy: * prior use of steroids allowed radiotherapy: * not specified surgery: * not specified

Keywords: localized resectable neuroblastoma localized unresectable neuroblastoma
application of pulse electrical stimulation around eye in dry eye disease patients scheduled for lasek surgery

Conditions: Dry Eye Disease

Summary: this study aims to evaluate the efficacy and safety of applying pulse electrical stimulation around eye in dry eye disease patients who are scheduled for lasek surgery.

duration of study period (per participant): screening period (0-14 days), intervention period (12 weeks), f/u period (2 weeks) patient needs to visit site at least 9 times (screening, baseline, v1, v2, v3, tele-visit, v4, v5, f/u tele-visit). baseline visit will be done on the day of surgery. visit 1, 2, 3, tele-visit, 4, 5, f/u tele-visit is 1 day, 3 days, 1 weeks, 2 weeks, 4 weeks, 12 weeks and 16weeks after baseline visit.

Eligibility criteria:
inclusion criteria: * participants must be 19 to 60 years of age, at the time of screening * those who are scheduled to get lasek surgery * according to the guidelines for diagnosing dry eye syndrome of korean corneal disease study group, those who fall under grade ii or higher * those with an osdi score of 13 or higher * a person who has no pregnancy plan during the clinical trial period and has agreed to an effective contraceptive plan for women of child bearing potential (wocbp) by a doctor * a person who voluntarily agreed to participate in this clinical trial exclusion criteria: patients who meet any of the exclusion criteria are excluded from this clinical trial. * a person with an uncontrollable systemic chronic disease (diabetes mellitus) * those who are allergic to drugs such as fluorescein solution or ophthalmic anesthetics * in a case where there is a history of receiving ophthalmic surgery known to affect the tear layer within the last 6 months (e.g., cataract, pterygium surgery) * a person who takes systemic drugs (e.g., tetracycline derivatives, antihistamine, isotretinoin) * a person who has eyelid diseases or structural abnormalities * a person with acute eye infection or inflammation of the eyeball not related to meibomian gland dysfunction * a person with abnormalities in the eyelids or eyelashes * a person with an eye condition or ophthalmic disease that is considered unsuitable for surgery (e.g., detachment of the retina, cataract) * pregnant or lactating women * those who can't understand or read the consent form of this clinical trial (e.g., illiterate or foreigners) * any other cases that pi considers hard to participate in this clinical trial (e.g., heart-related problems, seizure, epilepsy. patients transplanted metal or electronic device in head \& neck. patient suffering from unknown pain. patients who are warned not to use our clinical trial device or is prohibited from using it (e.g., pacemaker user).)
assessment of frailty as a risk factor for cardiac and vascular surgery

Conditions: Intellectual Frailty of Aging; Cardiovascular Diseases; Myocardial Infarction; Vascular Diseases; Heart; Dysfunction Postoperative, Cardiac Surgery

Summary: the purpose of this study is to assess the impact of frailty as a multidimensional risk factor on the outcomes of adult cardiac and vascular surgery. for the purpose of defining patient frailty a multimodal questionnaire has been developed including measurement of psychological, socioeconomical, neurological and behavioral aspects. this study also features an investigation of the possible relationship between sudden regional weather changes, individual meteorological susceptibility of the patients and the outcomes of adult cardiac and vascular surgery.


Eligibility criteria:
inclusion criteria: * patients, 18 years or older, admitted to the hospital for elective cardiac or vascular surgery. exclusion criteria: * not willing to participate. * pregnant women. * during active psychiatric hospital care. * patients with defined legal incapability or limited capability. * congenital or acquired speech impediment and locomotion disability of any kind. * non-evaluable patient due to communication problems and insufficient clinical information for the judgement of frailty (cfs). * patients admitted solely for elective surgery of the varices of the lower extremities. * patients with a transplanted heart.
effect of transcranial direct current stimulation (tdcs) on tobacco consumption

Conditions: Tobacco Use Disorder

Summary: the primary purpose of the protocol is to evaluate the effect of repeated application for 5 consecutive days of a real tdcs compared to the application of a placebo tdcs (sham procedure) on the evolution of tobacco consumption in the short term between day 1 and day 5. the study hypothesis is that a repeated application for 5 consecutive days of a real tdcs on the left dorsolateral prefrontal cortex region will reduce the craving induced causing a decreased of daily tobacco consumption between day 1 and day 5 which can persist at the final visit between day 15 and day 20.

smoking is a major public health problem and it is the leading cause of preventable death in the world. care should include education, psychotherapy and treatments, but despite these therapeutics, the smoking cessation process is often characterized by relapses. the main risk factor for relapse is craving. neurophysiological studies have provided evidence in the understanding of craving. this craving involves surface structures including the dorsolateral prefrontal cortex, accessible by neurostimulation. repetitive neurostimulation applies on this structures involved in craving could therefore modulate it. two non-invasive stimulation techniques exist: repetitive transcranial magnetic stimulation (rtms) and transcranial direct current stimulation (tdcs). the choice of tdcs is based on its ease of use, excellent tolerance, its better quality of placebo and low cost.

Eligibility criteria:
inclusion criteria: * aged 18 to 60 years old * smoking ≥ 5 years * smoking ≥ 15 manufactured cigarettes per day or ≥ 10 rolled cigarettes per day * fagerström test ≥ 5 * smokers who have at least an attempt to stop of minimum 7 days * written informed consent signed by the patient * affiliated to medical insurance exclusion criteria: * co-addiction (cannabis, alcohol, other drugs) * had test: d ≥ 8; a + d ≥ 19 * treatment by nicotine replacement therapy, bupropion or varenicline within 30 days prior inclusion * neuropsychiatric disease, considered serious by the investigator * psychotropic treatment (antidepressant, anxiolytic, antipsychotic) * skin scalp dermatosis * pregnancy or breastfeeding. positive pregnancy test. * patient under guardianship, trusteeship or judicial protection * patient in inclusion period for another clinical research protocol

Keywords: direct transcranial electrical stimulation (tdcs) sham procedure tobacco consumption craving
monitoring of sleep and behavior of children 3-7 years old receiving parent-child interaction therapy with the help of artificial intelligence

Conditions: Disruptive Behavior; Attention-deficit Hyperactivity; Oppositional Defiant Disorder

Summary: the purpose of this study is to develop an innovative wearable tracking protocol that will use artificial intelligence (ai) technology to monitor sleep and behavior of 3-7 year old children.


Eligibility criteria:
inclusion criteria - children: * ages 3-7. * outpatients or inpatients. * any gender, race or ethnicity. * able to provide developmentally appropriate informed assent, and legal guardians able to provide informed consent . * ebp severity rated above the clinically significant range (≥120; t-score ≥ 60) (eyberg child behavior inventory- ecbi; eyberg \& pincus, 1999). * need for more intensive behavioral treatments such as er visit for behavioral dyscontrol or hospitalization will not be exclusionary or exit criteria. * families approached for participation will be asked to commit to complete the treatment. * at least one primary caregiver and the identified child will have to be able to speak and understand english. exclusion criteria - children: * formal diagnosis of severe intellectual disability, autistic spectrum disorder level 3, or a psychotic disorder for the child. * parents not consenting to the study. * parents or child is not able to adhere to the study protocol. * a child who is reasonable expected to be unable to tolerate wearing the garmin device for at least 70% of the time during the day and night 70% of the days during the treatment (12 weeks). this is based on the principal investigator's discretion. * unable to speak and understand english. * refusal or withdrawal of consent, inability, or unwillingness to adhere to study procedures. * children in foster care. inclusion criteria - adults: * agree to wear garmin watch. * ages 18-99. * any gender, race, ethnicity. * able to provide informed consent. exclusion criteria - adults: * unable to speak and understand english. * refusal or withdrawal of consent, inability, or unwillingness to adhere to study procedures.

Keywords: emotional behavioral dyscontrol
ethical crossroads in nursing education

Conditions: Ethics, Narrative; Professional Identity Formation

Summary: in conclusion, understanding the variables influencing ethical decision-making among nursing students is crucial for developing interventions to minimize moral distress and promoting their ability to cope with ethical issues and dilemmas. while acknowledging the existence of ethical challenges, it is noteworthy that there is a dearth of studies investigating the intricate relationship between ethical sensitivity and the development of professional identity among nursing students. this research aims to fill this gap, advancing our understanding and providing valuable insights for shaping effective educational practices. in this improvement, the research problem is clearly stated: the need to explore the relationship between ethical sensitivity and professional identity among nursing students, with a call for further research to bridge the existing gap. in light of the identified research gap regarding the correlation between ethical sensitivity and the development of professional identity among nursing students, this study seeks to answer the following question: how does ethical sensitivity influence the formation of professional identity in nursing students within the context of contemporary healthcare environments, characterized by evolving technology and complex health systems?


Eligibility criteria:
inclusion criteria: - participants will be recruited from diverse online communities, including platforms such as facebook, whatsapp, and telegram. the decision to utilize these social media channels is based on their extensive usage within the target population, ensuring effective outreach and active participation. the undergraduate nursing students at the college are expected to establish dedicated social media groups for each academic level. exclusion criteria: * students not from nursing background education