Kornimate/medical-research-clean huggingface dataset:
early and late removal of the urinary catheter after rectum resection

Conditions: Colorectal Surgery; Rectal Cancer; Urinary Retention Postoperative

Summary: it was aimed to investigate the need for urinary retention and recatheterization in the postoperative period by removing the urinary catheter in patients undergoing low anterior resection, in the early or late period.

urinary catheter is placed before abdominal surgery to increase visualization during the operation, prevent bladder injury and provide perioperative urine output monitoring. it is especially useful in patients who will undergo low anterior resection, with a high risk of nerve damage and consequent urinary retention and bladder dysfunction. urinary catheter removal time differs between operations. traditionally, the urinary catheter is kept in place for 7 days because urinary retention occurs in some patients whose urinary catheter is displaced in the early period. as the urinary catheter retention time increases, the risk of urinary tract infection also increases. according to the current eras protocol, it is recommended to remove the urinary catheter 48 hours after the surgery in patients who have undergone colorectal surgery and are treated with epidural pain management. however, the eras protocol is not specific to patients who have undergone low anterior resection, which is the main point of our study and includes all patients who have undergone colorectal surgery. most authors still believe that prolonged retention of the urinary catheter will prevent urinary retention and long-term bladder dysfunction. in a randomized controlled study (published in 1999) that we encountered during our own literature search, early removal of the urinary catheter was associated with increased urinary retention \[2\]. in recent studies, some authors have associated the early removal of the urinary catheter with increased urinary retention \[3\], while others claimed the opposite and reported contradictory results \[4\]. advances in laparoscopic techniques have made it possible to visualize the hypogastric and pelvic nerves (nerves associated with urinary functions) during surgery. in addition to these developments, dissections on embryonic planes and tumor reduction with neoadjuvant chemotherapy protect these nerves during surgery.

Eligibility criteria:
inclusion criteria: * patients who will undergo low anterior resection due to rectal cancer in the department of general surgery of our university. * competent to consent to participate in trial * elective surgery * asa classification of 1\~3 exclusion criteria: * patients whose post-treatment status cannot be obtained. * having bladder surgery before * having a previous prostate surgery. * patient's refusal to participate in the study.
comparison of ketamine and esketamine in patients suffering from fibromyalgia syndrome.

Conditions: Fibromyalgia

Summary: ketamine and esketamine intravenous perfusions can modulate chronic pain. the purpose of this study is to determine if ketamine or esketamine are favorable for outpatients suffering from fibromyalgia.

ketamine and esketamine intravenous perfusions in pain clinic can modulate chronic pain and are therefore part of the therapeutic arsenal of the anesthesiologist in pain management. patients with fibromyalgia syndrome have elevated levels of glutamate in the brain. this is demonstrated by functional brain imaging techniques. elevation of glutamate is demonstrated in the posterior insular cortex, positively correlating with lower pain thresholds which is a hallmark of fibromyalgia syndrome. ketamine has (e.a.) an inhibitory role of the n-methyl-d-aspartate (nmda) receptor: it is a non-competitive antagonist of the nmda receptor. in this context, esketamine is available recently. this is the levorotatory form of ketamine. the main objective of this study is to measure if there is a difference between ketamine and esketamine on patients with fibromyalgia syndrome via the fibromyalgia impact questionnaire (fiq) and measurement of side effects after intravenous perfusion. the fibromyalgia impact questionnaire is a global assessment of symptoms: pain, function, fatigue, stiffness, discomfort when walking up stairs, difficulties at work, anxiety, depression, days not worked and days of good quality in the past week.

Eligibility criteria:
inclusion criteria: * male and female * between 18 and 75 years old * reads and writes french * diagnosis of fibromyalgia syndrome according to widespread pain index (wpi) and symptom severity scale (sss) score ≥ 13/31 * both molecules (ketamine and esketamine) were administered at least once during an analgesic infusion session in pain clinic * patient with regular medical follow-up by a pain specialist at least 3 times a year exclusion criteria: * allergy or intolerance to ketamine or esketamine * current infection, fever * pregnant or breastfeeding woman * serious cardiovascular disorders and severe hypertension * increased pressure of cerebrospinal fluid and severe intracranial disease * acute intermittent porphyria * untreated epilepsy * untreated glaucoma * difficult or impossible intravenous access * chronic liver disease child-pugh c

Keywords: fibromyalgia ketamine esketamine fibromyalgia impact questionnaire side effects chronic pain
bufei yishen granule for reducing acute exacerbation in gold stage 3 or 4 copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study aims to establish the treatment scheme of bufei yishen granule for gold stage 3 or 4 chronic obstructive pulmonary disease (copd), reducing acute exacerbation, improving exercise capacity and forming high quality evidence.

copd is a highly prevalent disease, with a prevalence among people 40 years of age or older of 10.1% worldwide and 13.7% in china. copd has become the third leading cause of death worldwide. frequent acute exacerbation and exercise limitation broadly exist in copd patients, especially those in gold stage 3 or 4. although appropriate pharmacological therapies have been proven to be effective in copd management, however, many gaps are still to be filled. for example, the adverse effects of pharmacologic therapies can never be ignored. the investigator's previous studies suggested that traditional chinese medicine (tcm) has effect on gold stage 3 or 4 copd. this is a multicenter, randomized, double-blind, placebo controlled trial to evaluate the effect of bufei yishen granule on reducing acute exacerbation in gold stage 3 or 4 copd subjects. after a 14-day run-in period, 348 subjects will be randomly assigned to treatment group or control group for 52-week treatment. the primary outcomes are frequency and duration of acute exacerbation. the secondary outcomes include mortality, pulmonary function, clinical symptoms, exercise capacity, quality of life and treatment satisfaction. safety will also be assessed.

Eligibility criteria:
inclusion criteria: * a confirmed diagnosis of gold stage 3 or 4 copd. * syndrome differentiation meets criteria of qi deficiency of the lung and spleen syndrome, qi deficiency of the lung and kidney syndrome or qi and yin deficiency of the lung and kidney syndrome. * age ranges from 40 years to 80 years. * with informed consent signed. exclusion criteria: * pregnant and lactating women. * patients with severe cardiovascular and cerebrovascular diseases. * patients with severe liver and kidney diseases. * patients with asthma, bronchiectasis, active pulmonary tuberculosis, pulmonary embolism, chronic respiratory failure or other severe respiratory diseases. * patients with tumor after resection, radiotherapy or chemotherapy in the past 5 years. * patients with severe neuromuscular disorders, severe arthritis or severe peripheral vascular diseases. * patients with severe cognitive and psychiatric disorders. * patients with diabetes. * patients who were administered oral glucocorticoids in the past 4 weeks. * patients who have participated in other clinical studies in the past 4 weeks. * people who are allergic to the treatment drugs. * patients who have experienced one or more acute exacerbation in the past 4 weeks.

Keywords: chronic obstructive pulmonary disease bufei yishen granule randomized controlled trial
bowen's technique in postural neck pain among dentist

Conditions: Neck Pain

Summary: no previous randomized control trial has investigated the effectiveness of bowen's technique on health status in dentists suffering from postural neck neck pain. moreover, there is limited evidence and low agreement regarding the effect of bowen's therapy on neck pain. thus, this study aims to answer the question: bowmen's technique is effective for improving neck pain dentists' function by reducing pain, and disability, and improving posture, and health status, without need for ergonomic alternation?"

bowen technique may be used for relaxation of tightening muscles in poor posture. the findings suggest that bowen therapy has inconsistent immediate effects on postural control and pain threshold in healthy subjects. further studies are needed using symptomatic participants. no previous randomized control trial, to our knowledge, has investigated the effectiveness of bowen's technique on health status in dentists suffering from postural neck pain. moreover, there is limited evidence and low agreement regarding the effect of bowen's therapy on neck pain. thus, this study aims to answer the question: bowen's technique is effective for improving neck pain dentists' function by reducing pain, and disability, and improving posture, and health status, without need for ergonomic alternation?"

Eligibility criteria:
inclusion criteria: * both male and females * age between 25-50 years. ( house officers and assistant professor) * working hours \>5 hours. * history of cervical pain \>2 months. * year of practice =\<1 year * treated more than 5 patient a day exclusion criteria: * cervical fracture * cervical radiculopathy * any surgery to neck and shoulder * rheumatoid arthritis * sever pain according to numeric pain rating scale (nprs) * long term anticoagulant or corticosteroid therapy

Keywords: pain dentist neck bowen technique
treating acutely agitated patients with asenapine sublingual tablets

Conditions: Agitation

Summary: our proposal is to administer asenapine to patients who are clinically agitated and in need of immediate intervention. at present there are no controlled studies that we know of that explores the use of asenapine for this purpose. establishing the utility of asenapine for this common clinical problem will support its use as an additional treatment option in acutely agitated patients.

a psychiatrist (blinded) will assess the patient for agitation and their capacity to consent. patients will be informed about the study and asked to complete informed consent prior to being included in the study. patients who decline will not be included. a nurse (blinded) will administer either 10mg asenapine or placebo sublingually in a randomized fashion. efficacy in reducing acute agitation will be evaluated using the panss-ec. a trained rater (blinded) will rate patients at baseline and at 15, 30, 60, 90 and 120 minutes (or endpoint) after medication administration. efficacy in reducing acute agitation will also be evaluated using the clinical global impression scale (cgi). a trained rater (blinded) will rate patients at baseline cgi-severity and cgi-change at 60 and 120 minutes (or endpoint) after medication administration. the need for additional medications, interventions or physical restraints will be recorded and constitute the endpoint for that patient. demographics, diagnoses, blood alcohol level, urine toxicology, and urine pregnancy will be collected.

Eligibility criteria:
inclusion criteria: * patients will be between the ages of 18 and 65 * be acutely agitated as determined by a total score of ≧ 14 on the panss-ec and at least one individual item score of ≧ 4 * patients must have the capacity to provide informed consent, and such consent will be obtained prior to participation exclusion criteria: * patient is knowingly pregnant * patient is less than 18 or greater than 65 years old * patient had a past adverse or allergic response to asenapine

Keywords: acute agitation schizophrenia bipolar psychosis panss-ec
one trial to evaluate the safety, tolerability and efficacy of jcxh-213 in patients with r/r b-nhl

Conditions: B-Cell Non-Hodgkin Lymphoma-Recurrent; B-Cell Non-Hodgkin Lymphoma-Refractory

Summary: evaluate the safety and efficacy of jcxh-213 in patients with relapsed/refractory b-cell non-hodgkin lymphoma

patient will receive study treatment in the treatment observation period. after the end of the treatment observation period, patients will be allowed to continue to receive treatment if there is no major safety problems and the investigator judges that the patient may continue to benefit.

Eligibility criteria:
inclusion criteria: * cytologically or histopathologically confirmed cd19-positive b-cell hodgkin lymphoma according to who 2022 criteria, including but not limited to pathologically confirmed (1) diffuse large b-cell lymphoma, not otherwise specified (dlbcl, nos); (2) follicular lymphoma (fl); (3)histologically transformed into diffuse large b-cell lymphoma; (4) primary mediastinal large b-cell lymphoma (pmbcl); (5) high-grade b-cell lymphoma (hgbcl) etc. * ecog performance status 0 to 1. * existing measurable lesions (lugano 2014 criteria, as detailed in appendix 2), meeting one of the following conditions: 1) nodal lesions with a long axis length exceeding 15 mm (short axis length is measurable); 2) extra-nodal lesions with both long axis and short axis lengths exceeding 10 mm. exclusion criteria: * patients with other malignant tumors within 5 years before screening, except for adequately treated cervical carcinoma in situ, basal cell or squamous cell skin cancer, local radical prostatectomy, radical ductal carcinoma in situ, and radical thyroidectomy. * b-cell non-hodgkin lymphoma with active primary or secondary central nervous system involvement. * life expectancy less than 3 months.
effects of 8-week core stabilization exercise with vitamin d on pain and functional limitation in adults

Conditions: Low Back Pain

Summary: chronic non-specific low back pain (cnslbp) is a prevalent condition contributing to pain, functional limitations, and reduced quality of life. core stabilization exercises (cse) have shown promise in enhancing spinal stability and reducing symptoms. additionally, vitamin d supplementation plays a critical role in musculoskeletal health. study objective will be to determine combined effect of vitamin d supplementation and core stabilization exercises is better than core stabilization exercises alone in reducing pain-related and functional independence among chronic non-specific low back patient a randomized controlled trial will be conducted on 52 adults aged 25-45 diagnosed with chronic non-specific low back pain.

subjects will be divided into two groups: the intervention group will receive an 8-week core stabilization exercises program alongside daily vitamin d supplementation, while the control group will receive either core stabilization exercises alone visual analog scale (vas), and oswestry disability

Eligibility criteria:
inclusion criteria: * adults aged 25 to 45 years will be included. * both gender male /female will participate. * subjects with diagnosed non-specific low lumber pain persisting for at least 12 weeks will be included. * subjects must have baseline pain score of ≥4 on the visual analog scale. * confirmed serum vitamin d levels \<30 ng/m will be included exclusion criteria: * low lumber pain due to specific causes such as fracture malignancy infection or inflammatory diseases (e.g. ankylosing spondylitis). * presence of significant comorbidities that could interfere with participation (e.g. cardiovascular neurological or respiratory disorders). * history of spinal surgery within the last year. * subjects currently taking vitamin d supplements or undergoing other treatments for vitamin d deficiency. * use of medications such as corticosteroids or opioids that might affect pain perception or functional assessment. * enrolled in any other physical therapy or pain management program within the last three months.
ex-vivo cof study for lung cancer observation

Conditions: Lung Cancer

Summary: accessing nodules located in the most outer part of the lung is challenging. tissue that will be removed from the lung will be used to see if we can reach and see the nodule with a very small camera. this camera that may reach in the smaller and outer airways is called a composite optical fiberscope (cof). the purpose of this study is to evaluate insertion ability of the cof and visualization of the lung tumor by the cof. in order to do so, we plan to evaluate 50 patient samples from the university health network over the span of 2 years.

peripheral pulmonary lesions (ppls), which include pulmonary nodules and masses, are a common problem in pulmonology practice. the incidence of ppls will likely increase given the growing adoption of chest ct screening for lung cancer. there are several guidelines available for management of ppls. if bronchoscopy is selected as the method of diagnosis, conventional bronchoscopy has been one platform used for decades to diagnose ppls. however, conventional bronchoscopic techniques have significant limitations and overall low diagnostic yield for most ppls. as a result, innovative bronchoscopic techniques and technologies have evolved over the last decade to diagnose ppls more accurately. however, accessing to ppls located in the most peripheral part is still challenging. as a new method to diagnose and localize cancers, photodynamic diagnosis (pdd) has been gaining attention. pdd is a new technique where a photosensitizer injected intravenously accumulates in the abnormal lesion, then its fluorescence can be detected by a detector. to conduct pdd for ppls, we collaboratively developed a parallel-type composite optical fiberscope (cof) with an outer tip diameter of 0.97 mm with ok fiber technology (kyoto, japan). its small size and flexibility of the tip enable it to be inserted into animal ultrasmall airways. the outer membrane of the fiberscope is made from polytetrafluoroethylene in the cof's insertable section and is hydrophilic coated, which reduces frictional forces when in the contact with the bronchial wall resulting in smooth insertion of the fiberscope. as the cof has illumination fibers and a laser fiber inside, simultaneous white-light and fluorescence imaging with real-time monitoring can be performed to confirm the tip position of the fiberscope during laser irradiation. in this study, we want to evaluate the cof regarding the quality of white-light images and the accessibility of lung tumors located in the peripheral area of the lung.

Eligibility criteria:
inclusion criteria: 1. any patients scheduled for lobectomy or anatomical segmental resection for malignant lung tumors. 2. 18 years of age or older. exclusion criteria: 1) any patients with inability to give informed consent.
utility of sodium lactate infusion during septic shock

Conditions: Septic Shock

Summary: ulis-1 is an open-label pilot study concerning utility of molar sodium lactate in fluid balance in septic shock patients

ulis-1 consists in three arms of treatment during the first 24hrs of septic shock treatment. * normal saline * sodium lactate 2.5ml/kg in 60min then * either 0.25 or 0.5ml/kg/h during 24hrs main criteria is fluid balance at 48hrs

Eligibility criteria:
inclusion criteria: * presence of septic shock * requiring vascular filling within 12 hours after introduction of noradrenaline. septic shock is defined as sepsis with persistent hypotension requiring the administration of vasopressors to maintain rte \> 65mmhg. * social insurance exclusion criteria: * pregnancy * cardiac arrest * more than 50ml/kg of fluid loading * chronic renal failure with chronic hemodialysis or the investigators estimate a need for renal replacement therapy in the following 24hrs * child c or acute liver failure with pt\<40% (unless avk) * plasmatic sodium \ 145mmol/l * metabolic alkalosis with ph\>7.45

Keywords: sepsis fluid balance metabolism ischemia-reperfusion treatment
podcasting cervical cancer prevention for aaw

Conditions: Cervical Cancer

Summary: for african american women (aaw) in houston, cervical cancer mortality is disproportionate to their racial and ethnic counterparts.most notably, lack of human papillomavirus (hpv) screening, vaccination, and later diagnosis increase cervical cancer mortality. however, cervical cancer is largely preventable. while previous research has identified only a few social determinants that are specifically related to cervical cancer, there may be a host of additional social and cultural factors that contribute to a lack of preventative behavior. the overall objective of the proposed study is to gather preliminary data to determine whether the use of concept mapping methodology is useful in identifying unique sociocultural determinants of cervical cancer prevention behavior, and to pilot test the feasibility of a podcast video developed using the information garnered from the concept mapping procedure. it is hypothesized that the resulting podcast video will increase hpv knowledge and behavioral intentions. proof of concept and feasibility are needed first, in determining the utility of both the methodology and media development procedures, as well as data on preliminary effect outcomes, before further investigation and program development.


Eligibility criteria:
inclusion criteria: * self-identify as african american * biological female sex * speak and read english * 18 years old or older * not currently or previously diagnosed with cervical cancer or cervix dysplasia exclusion criteria: • history of hysterectomy

Keywords: cervical cancer african american women cancer prevention
pet-ct predicting segement specific lymph nodes metastasis

Conditions: Non Small Cell Lung Cancer; Lymph Node Metastasis; Positron Emission Tomography

Summary: this study is a multicenter prospective clinical study that aims to evaluate the predictive value of preoperative pet-ct results (such as suv uptake, size of tumor lymph nodes, and differences in fdg uptake compared to surrounding tissues) for lymph node metastasis in patients with non-small cell lung cancer. during surgery, all patients underwent systematic mediastinal lymph node dissection. the final pathological results were used to assess the predictive value of pet-ct for segment-specific lymph node metastasis.


Eligibility criteria:
inclusion criteria: * solitary tumor, or multiple tumors with only ground-glass nodules (ggns) apart from the primary lesion. * diameter of the primary lesion ≤5cm, with a ctr between 0.5 and 1. * no enlarged mediastinal lymph nodes observed on preoperative contrast-enhanced ct. * pathological confirmation of non-small cell lung cancer (nsclc) either before or during surgery. * systematic lymph node dissection performed during surgery. * no prior radiotherapy or chemotherapy for initial treatment. * no history of malignant tumors. exclusion criteria: * locally advanced or distant metastasis. * pleural dissemination observed during surgery. * history of malignant tumors. * received neoadjuvant therapy. * systematic lymph node dissection not performed during surgery. * histopathological examination reveals lung malignancies other than non-small cell lung cancer (nsclc).