Kornimate/medical-research-clean huggingface dataset:
brief new treatment for suicide attempts

Conditions: Suicide, Attempted; Drug Use; Alcohol; Use, Problem

Summary: individuals with alcohol or drug use problems who are hospitalized for suicide attempt are at high risk for reattempt. this treatment development study adapts a promising outpatient intervention to prevent suicide reattempt in order to administer it during hospitalization to individuals with alcohol and drug use problems, and to test the adapted intervention in a pilot randomized controlled trial.


Eligibility criteria:
inclusion criteria: * suicide attempt within one week of hospitalization with acknowledgment of some intent to die using a standard item * problematic alcohol or drug use as determined by score \>8 on alcohol use disorders identification test, audit or \>3 on the 10-item version of the drug abuse screening test, dast-10 * admission to hospital * residence within 40 miles of strong memorial hospital exclusion criteria: * under age 18 * treated in ed, cpep, or observation unit only * unable to communicate with the researcher in english * unable to comprehend the nature of the study * participation untenable from a medical (e.g., intubated), psychiatric (e.g., florid psychosis), or behavioral (e.g., refusing to speak with staff) standpoint * short hospital length of stay, ruling out administering three sessions of the therapy prior to discharge
evaluation of safety and efficacy of the prepextm device for rapid scale up of adult mc programs in zimbabwe

Conditions: Circumcision Adult; HIV CDC Category B2; HIV Infections

Summary: the protocol, approved by the medical research council, was issued to assess the safety and efficacy of the non-surgical device for applying it to the national scale up of adult male circumcision in zimbabwe

models show that to have the highest impact on the hiv epidemic, circumcision of up to 80% of men in high prevalence countries, where mc rates are low, needs to be achieved (unaids 2009; manicaland hiv/std prevention project, 2008; bollinger, et al, 2009). hallett and colleagues in 2008 showed that for zimbabwe specifically, hiv incidence could be reduced between 25% to 35% if about 50% of men are circumcised. all modelings conducted show that mc programs must be part of a comprehensive hiv prevention package as mc alone will not tip the hiv epidemic into a terminal decline. the prepex device offers hope for rapid scale up of adult male circumcision in resource limited settings. once the safety and efficacy have been established, it is important to conduct operations research to determine how best to implement both device and surgical circumcisions in the national program. thus, the zimbabwe mohcw is planning a three phase trial in order to determine the safety of the prepextm device, its performance and the ease of use in an implementation roll out.

Eligibility criteria:
inclusion criteria: * ages 18 - 30 years * uncircumcised * wants to be circumcised * agrees to be circumcised by any of the study methods,prepex or surgical as appropriate * hiv sero-negative * able to understand the study procedures and requirements * agrees to abstain from sexual intercourse and to keep caution not to directly rub the cut area if masturbating, for 8 weeks post removal (9 weeks total) * agrees to return to the health care facility for follow-up visits (or as instructed) after his circumcision for a period of 8 weeks post removal (9 weeks total) * subject able to comprehend and freely give informed consent for participation in this study and is considered by the investigator to have good compliance for the study * subject agrees to anonymous video and photographs of the procedure and follow up visits * agrees to stay overnight at the hospital in order to follow pain measurements in the first 16 hours exclusion criteria: * active genital infection, anatomic abnormality or other condition, which in the opinion of the investigator prevents the subject from undergoing a circumcision * hiv sero-positive * subject with the following diseases/conditions: phimosis, paraphimosis, warts under the prepuce, torn or tight frenulum, narrow prepuce, hypospadias, epispadias * known bleeding / coagulation abnormality * uncontrolled diabetes * subject that to the opinion of the investigator is not a good candidate * subject does not agree to anonymous video and photographs of the procedure and follow up visits * refusal to take hiv test.

Keywords: male circumcision hiv zimbabwe
hla analysis in autoimmune encephalitis and related disorders

Conditions: Autoimmune Encephalitis; Imbic Encephalitis; Autoimmune Cerebellar Ataxia; Stiff-person Syndrome

Summary: autoimmune encephalitis (ae) are characterized by subacute onset of memory deficits, altered mental status or psychiatric symptoms, frequently associated with seizures, inflammatory cerebrospinal fluid and in cases with prominent limbic involvement, typical magnetic resonance imaging. several autoantibodies (ab) may be detected in ae, although its detection is not mandatory to establish a diagnosis. these ab mainly recognize different synaptic and cell-surface proteins in the central nervous system, and are thought to be pathogenic as they alter the normal location or function of its antigens. the primary trigger of the immune response is unknown for most of ae. in addition to acquired susceptibility, genetic predisposition may also be important in the pathogenesis of ae. human leukocyte antigen (hla) is the genetic factor most frequently associated with autoimmune diseases, due to its genetic complexity and key role in the adaptive immune response. the aim of the study is to describe hla profile in three groups of autoimmune encephalitis and related disorders: anti-lgi1, anti-caspr2 and anti-gad neurological diseases.


Eligibility criteria:
inclusion criteria: 1. presence of anti-lgi1, anti-caspr2 or anti-gad antibodies in serum or cerebrospinal fluid; 2. clinical picture compatible with the detected antibody (limbic encephalitis in anti-lgi1; limbic encephalitis, neuromyotonia or morvan's syndrome in anti-caspr2; limbic encephalitis, cerebellar ataxia or stiff-person syndrome in anti-gad exclusion criteria: - absence of complete clinicobiological data.
effects of hydroxychloroquine on oral complaints of sjögren patients

Conditions: Sjögren's Syndrome; Xerostomia

Summary: chronic inflammation that comprises the exocrine glands' function leads to xerophthalmia and xerostomia in sjögren's syndrome. the oral consequences range widely and they are related to decreased salivary output. hydroxychloroquine may inhibit cholinesterase activity in salivary glands via interference with antigen processing mechanism, and thus, the investigators' hypothesis was that salivary gland function may be improved if treated with hydroxychloroquine. the effects of hydroxychloroquine on the salivary flow rate, subjective and objective parameters of the patients were also assessed.


Eligibility criteria:
inclusion criteria: * patients who were recently diagnosed with primary ss according to american-european criteria and who were scheduled for hcq treatment in ege university faculty of medicine, department of rheumatology exclusion criteria: * sjögren patients consuming alcohol or tobacco

Keywords: sjögren's syndrome hyposalivation mouth dryness complications
feasibility of 11c-met pet/mri imaging in pediatric brain fossa tumors

Conditions: Posterior Brain Fossa Tumors in Children

Summary: brain tumors are the most common solid tumors in children and are the second most common cause of cancer-related death among this population. posterior brain fossa tumors represent about 50% of children brain tumors. recently, knowledge in molecular biology has permitted to identify different tumors subgroups of very different prognosis. today, surgery removal of the tumor is the mandatory. neuro-oncological treatment differs depending on the histological and molecular subgroup. with classical magnetic resonance imaging (cmri), distinction between different types of posterior fossa tumors remains difficult. positron emission tomography combined with mri (pet/mri) has proven its benefits for the management of brain tumors. the direct spatiotemporal correlation makes possible the assessment of metabolic, anatomical and functional information. pet/mri would provide precisions on the pre-therapeutic characterization of tumors, which could permit to modify the patients' care. l- \[methyl-11c\] methionine (11c-met) is currently the gold-standard tracer used in neuro-oncology, but few data exists in children. 11c-met pet/mri assessment seems promising, but has not been studied enough. to the best of our knowledge, there is no specific study on primary brain tumors of the posterior fossa in children using 11c-met pet/mri. the primary objectives of this first pilot study is to evaluate the practical feasibility of 11c-met pet/mri imaging (machine accessibility and imaging interpretability) before surgery in a population of children older than 5 years old with posterior fossa tumors. the secondary objectives aim to describe : * the pet/mri parameters of the different tumors studied, * and the patient's participation acceptation. this feasibility study will allow us to standardize the pet/mri measurements; this could allow us to discriminate, in a larger study, the different tumor subgroups before surgery.


Eligibility criteria:
inclusion criteria: * patients ≥ 5 years old and \< 18 years old at enrollment, * with primary posterior brain fossa tumor, metastatic or not, * hospitalized in the department of pediatric neurosurgery of femme-mère-enfant hospital, and for whom a surgery is scheduled, * covered by national health insurance, * patient's parents or legal guardians who have provided written informed consent prior to participation in the study. exclusion criteria: * patients with contraindication for mri (claustrophobia, carrying metallic object) * patients with contraindication for gadolinium injection (including pregnancy and breastfeeding) * patient with recurring posterior brain fossa tumor * patient with brain stem infiltrative tumor

Keywords: pet/mri 11c-met posterior brain fossa tumors children surgery feasibility
comparison of a novel wound dressing stratamed versus current clinical practice after follicular unit extraction hair transplantation

Conditions: Wounds and Injuries

Summary: follicular donor sites on the scalp for hair transplantation will be treated with studied products post harvest. a randomized side of the scalp will be treated with stratamed, the other side with standard clinical practice. subjects will be assessed live immediately post treatment and in 2 sessions during the healing phase post harvest. subjects will also complete subject reported outcome questionnaires at home between study visits.


Eligibility criteria:
inclusion criteria: * over 18 years old * able to provide informed consent * planning to undergo follicular unit extraction hair restoration exclusion criteria: * significant medical or surgical conditions * unable to give informed consent * patient unable to apply topical device * allergy or intolerance to ingredients or excipients of the formulation of studied products * pregnancy

Keywords: stratamed wound healing follicular unit extraction hair transplantation
biodegradable stent implantation in biliary benign strictures.

Conditions: Biliary Tract; Biliary Tract Diseases; Stenosis; Follow-Up Studies; Stents

Summary: spanish registry of resorbable stent implantation in biliary benign strictures. this registry is sponsored by the spanish society of vascular and interventional radiology (servei) and conducted by the research group gitmi (group of research in minimally invasive techniques) of the university of zaragoza (spain). a software tool hosted on the official website of servei and the journal intervencionismo will be used for data collection a(https://estudios.watsoncme.com).

this is an prospective observational study of patients that have been implanted a biodegradable stent in the biliary tree. patients are recruited when the stent is implanted, and the investigators perfom a patients follow-up during 1, 3, 6, 12, 24, 36, 48 and 52 months.

Eligibility criteria:
inclusion criteria: * older than 18 years-old * informed consent * non-lithiasic chronic bening single or multiple stenosis * possibility of follow-up plus 1 year exclusion criteria: * under 18 years old * unsigned consent * non treatable coagulopathy * acute signs of infection * diagnosis of neoplasia
respiratory viral infections in pediatric transplantation

Conditions: Infection in Solid Organ Transplant Recipients; Complications of Organ Transplant; Respiratory Viral Infection

Summary: a retrospective cohort of solid organ transplant (sot) and hematopoietic stem cell transplant (hsct) recipients will be assembled to determine the incidence of respiratory viral infections diagnosed during an inpatient admission in the first year post-transplant. a sub-cohort of patients that develop a respiratory viral infection within one year of transplantation will be leveraged to investigate factors associated with mortality in the three months after respiratory viral infection.

the purpose of the study is to 1) determine the incidence of respiratory viral infections diagnosed during the first year post sot and hsct; 2a) determine the all-cause mortality within 3 months of a respiratory viral infection diagnosed during an inpatient admission in the first year post sot and hsct; 2b) determine the proportion of deaths within 3 months of a respiratory viral infection diagnosed during an inpatient admission deemed to be directly attributable to that infection; and 3) to identify factors known at time of onset of the inpatient respiratory viral infection that are associated with all-cause mortality. the study cohort will consist of any sot or hsct recipient ≤18 years of age that received their transplant between january 1st, 2010 and june 30th, 2013. th cohort will determine the incidence of respiratory viral infections diagnosed during an inpatient admission in the first year post-transplant. a sub-cohort of patients that develop a respiratory viral infection within one year of transplantation will be leveraged to investigate factors associated with mortality in the 3 months after respiratory viral infection. baseline and demographic characteristics will be summarized by standard descriptive summaries. categorical variables will be summarized by frequencies while continuous variables will be summarized using mean, standard deviation and/or median, twenty-fifth and seventy-fifth percentiles, minimum, and maximum. this is a minimal risk study using data that will be collected retrospectively from medical charts. the only potential risk would be loss of confidentiality.

Eligibility criteria:
inclusion criteria: * males or females age 0 to \<18 years at the time of hsct or sot * transplantation occurred between january 1st, 2010 and june 30th, 2013. exclusion criteria: * none
the effectiveness of a weight management program in patients who have completed treatment for endometrial cancer

Conditions: Endometrial Cancer; Overweight

Summary: the primary purpose of this study is to evaluate the effectiveness of a 12-month comprehensive weight management program on weight change in overweight/obese patients following treatment for endometrial cancer. during the study period, subjects will be monitored for recurrence during routine clinic visits a secondary exploratory purpose of this study will be to evaluate the gut microbiome in this intervention group and the changes that may occur while participating in a weight loss and weight management program.

all enrolled subjects will participate in the profile weight loss and weight management program for a period of 12 months. they will work with a profile lifestyle coach weekly to develop a personalized nutrition plan, discuss their activity, and lifestyle behavior as done with all profile members. a comparison of similar retrospective chart reviews based on age, weight in pounds and stage of cancer will be conducted using the electronic medical record (emr). all enrolled subjects will collect and return a fecal specimen prior to beginning the weight management plan and again after 6 months of participation. the stool sample will be used to understand gut health.

Eligibility criteria:
inclusion criteria: * 18 years of age and older with a diagnosis of endometrial cancer * no known metastatic disease * has completed all treatment for their endometrial cancer at least 2 months prior to enrollment. * has a bmi (body mass index) of 30 or higher * ability to understand the purpose of study and willingness to sign consent * willingness to collect fecal specimens at the required time points * capable of following the dietary guidelines and instructions for the profile weight management plan * agrees to sharing information between profile and sanford research study personnel exclusion criteria: * bmi (body mass index) less than 30 * known metastatic disease * receiving treatment or expected to receive treatment for endometrial cancer or any other cancer * any psychological, familial, sociological conditions that the physician feels will interfere with medical follow-up and compliance on the study * taking insulin for diabetes (oral medications for diabetes allowed) * use of corticosteroids for a chronic medical condition * known liver disease * bowel or stomach disorders that the physician feels would interfere with profile participation. * any history of malabsorption syndrome or substantial amounts of small bowel or stomach surgery that impairs nutrient absorption
emma: empowerment, motivation and medical adherence

Conditions: Diabetes Mellitus, Type 2

Summary: emma: empowerment, motivation and medical adherence. a consultation program based on dialogue tools for adults with poorly regulated type 2 diabetes.

traditionally, the success of patients to manage their diabetes has been judged by their ability to adhere to a prescribed therapeutic regimen, and efforts have been spent developing strategies to promote adherence. it is estimated that 20% to 50% of patients with chronic conditions are not adherent to their prescribed medication regimen, with non-adherence being defined as \<80% adherence to prescribed, relevant medication. the treatment regimen often comprises several elements such as poly-pharmacy including insulin administration, self-monitoring of blood glucose, diet and physical exercise. it is thus not just a matter of 'taking a pill or not' but implies lifestyle changes, knowledge and competence, and internal motivation for self-management. the investigators developed a consultation program based on dialogue tools. the emma program aims to support medication adherence and blood glucose control by facilitating rapport, exploring patient concerns and challenges, enabling knowledge exchange and supporting goal-setting and action-planning. a pilot test of the program appeared feasible and acceptable to patients and health care professionals and showed significant decrease on hba1c. emma is now ready to be tested in a randomized controlled study (rct) study.

Eligibility criteria:
inclusion criteria: * adults type 2 diabetes ≥ 18 år * type 2 diabetes ≥ 1 år * hba1c ≥ 64 mmol/mol (≥ 8%) at the last three measures before randomisation * taking medication for type 2 diabetes • - speak, read and understands danish exclusion criteria: * participating in other intervention research projects during the trial period * being treated by a psychiatrist or psychologist during the period * reduced sight or blindness

Keywords: adults, dialogue tools, outpatient clinic visits
interest of challenge tests for diagnosis of immediate hypersensitivity against iodinated contrast agents

Conditions: Allergic Reaction

Summary: iodinated contrast agents (ica) are widely used in medical imaging. they provide however a risk of immediate hypersensitivity reactions (ihs). the risk of anaphylactic shock is estimated at 1/100 000 injections. nevertheless, for safety reasons and to limit undesirable effects, the reintroduction tests are not conducted along similar lines to throughout scan or arteriography. moreover, reintroduction protocols are actually not standardized, in terms of injected volume and doses progression. it should be evaluated the relevance of the reintroduction tests with injection of a low volume and ensure the absence of reaction during the ica injections under real conditions. the investigators are assuming that the realization of a provocation test by intravenous reintroduction with a reduced dose of ica improves the predictive value of ihs in comparison with only cutaneous tests.

the main objective of this study will be to estimate the negative predictive value of the combination of cutaneous tests and provocation test by intravenous reintroduction in the ihs to iodinated contrast agents.

Eligibility criteria:
inclusion criteria: * major patient * having suffered single-blind reintroduction * having benefited from cutaneous tests and ica reintroduction test in the framework of ihs exclusion criteria: * patient with delayed hypersensitivity * opposed to use data

Keywords: iodinated contrast agents immediate hypersensitivity reactions reintroduction tests
autologous fat grafting in radiated soft tissue reconstruction

Conditions: Breast Cancer; Radiation Fibrosis; Fat Grafting

Summary: the purpose of this study is to observe the effect of autologous fat grafting on soft tissue reconstruction of the breast following radiation treatment. moving fat from one part of the body to another has been used for reconstruction for hundreds of years. however, it is not fully understood how well this works in reconstruction after radiation is used for cancer treatment.

this is a single-arm, prospective pilot study that will objectively assess outcomes in patients electively undergoing aft for breast or chest wall reconstruction. patients planning to undergo autologous fat transfer for breast or chest wall reconstruction will be enrolled prospectively. as this is a pilot study, the study team plans to enroll ten (10) patients to demonstrate the feasibility of the protocol and pathway as well as establish preliminary data for extramural funding. the research will include capturing 2-dimensional (2-d) and 3-dimensional (3-d) photographs as well as ultrasound (us) soft tissue assessments to determine volume retention and changes in the reconstructed area. participants will undergo this imaging of their breast and chest wall and complete two questionnaires to evaluate patient satisfaction, quality of life, and late effects of radiation following fat grafting over a 12-month period, all standard of care. the 3d photographs and us are routinely used in practice but will be performed for research purposes in this study.

Eligibility criteria:
inclusion criteria: * able to give consent * undergoing elective autologous fat grafting * previously treated for breast cancer * previous treatment included radiation therapy to the breast/chest wall. exclusion criteria: * unable to give consent * no history of radiation to the breast or chest wall * no prior treatment for breast cancer * no indication for autologous fat grafting * currently pregnant or breastfeeding * currently consuming nicotine products (smoking, vaping, patches, gum) * under the age of 18