Kornimate/medical-research-clean huggingface dataset:
influence of healing time on the outcomes of alveolar ridge preservation in periodontally compromised extraction sockets

Conditions: Tooth Loss

Summary: the goal of this clinical trial is to histologically, clinically, and radiographically evaluate the healing sequelae of periodontally compromised extraction sockets grafted with bio-oss collagen® at 3 and 6 months following tooth extraction in molar sites. the main question it aims to answer is: does healing time influence the histologic, clinical, and radiographic outcomes following socket grafting (alveolar ridge preservation) in periodontally compromised extraction sockets. researchers will compare a healing time of 3 months to a healing time of 6 months (conventional healing duration) to see if a shorter duration is viable for implant placement. participants will: take a cone-beam computed tomography (cbct) scan to prepare for the surgical procedure. undergo tooth extraction and the extraction socket will be grafted with bio-oss collagen® and a collagen membrane bio-gide® will be placed to stabilize the graft material. return at 2 weeks for suture removal and either 3- or 6-months post-extraction for implant placement. return at 2 weeks post-implant placement for suture removal, 3 months for prosthesis fabrication, 4 months for final prosthesis loading, and 1 year post-loading.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * asa (american society of anesthesia) status i or ii * need for molar extraction due to periodontal disease with or without chronic endodontic involvement, complying with the presentation of periodontitis stage iii/iv * radiographic evidence of a bone dehiscence on at least one socket wall, where the height of the horizontal (suprabony) component of the defect (alveolar bone crest - cement-enamel junction) is \>50% of the corresponding root length as measured on cbct scans prior to extraction (ben amara et al., 2021) * radiographic evidence of at least 3 mm of residual bone wall height * presence of at least one adjacent tooth to the extraction site * treatment plan must include tooth replacement with an implant-supported fixed dental prosthesis exclusion criteria: * extraction of multiple adjacent teeth * acute infection associated with the tooth to be extracted or with adjacent teeth * current smokers (\>10 cigarettes per day) * uncontrolled diabetes mellitus (hba1c \>7.0) * any active oral or systemic acute infections * currently receiving chemo- or radiotherapy or a history of radiotherapy in the head and neck area * diseases or medications that may compromise normal wound healing

Keywords: ridge preservation tooth extraction
knowledge and attitudes regarding healthy lifestyle and health behavior change in cancer patients and their partners; a pilot study

Conditions: Breast Cancer; Testicular Cancer

Summary: the investigators will perform a pilot study to gain insight into attitudes, barriers and facilitators for health behavior change in cancer patients and their partners. results of this pilot will be used to design suitable questionnaires to investigate health behavior change in a larger cohort of patients and their partners. it will also direct future interventions to adequately target patients and, potentially, their partners to improve their lifestyle following a cancer diagnosis.

the investigators will perform semi-structured interviews with cancer patients and their partners in order to explore knowledge, attitudes, barriers and facilitators regarding health behavior change following cancer treatment.

Eligibility criteria:
inclusion criteria: * between 18 and 65 years of age * have completed adjuvant or curative chemotherapy (in bc and tc patients, respectively) or started adjuvant hormonal therapy alone (in bc patients) between 6 and 24 months previously * have no signs or symptoms of recurrent disease * be in follow-up at the department of medical oncology of the umcg. exclusion criteria: * signs or symptoms of recurrent disease * mental disability
efficacy of noninvasive ventilation in amyotrophic lateral sclerosis (als)

Conditions: Amyotrophic Lateral Sclerosis; Motor Neuron Disease

Summary: this study will test the hypothesis that noninvasive ventilation (niv) as prescribed in current medical practice for use in amyotrophic lateral sclerosis (als) patients fails to deliver adequate breathing support over a night of use in the patient's home. als patients who come to the als center for their routine 3 month follow up exam and are currently using niv will be asked to complete questionnaires regarding their quality of sleep, quality of life and general level of function, and to undergo a home sleep study, using a safe, comfortable and reliable breathing monitoring system during a night of sleep. if the questionnaires or the sleep study show failure of the breathing device, the investigators will work with the patient to fix the problem and then offer a second study to make sure that the changes were helpful. the results of this study may help to develop subsequent studies and to improve the guidelines used for care of als patients.

amyotrophic lateral sclerosis (als), also known as "lou gehrig's disease", is a fatal disorder that causes breathing failure due to progressive weakness of the muscles of breathing. breathing assist devices known as noninvasive ventilation (niv) are offered to als patients when their breathing function worsens. these devices deliver breathing assistance via a mask on the nose or nose and mouth, and are thought to be particularly important to be used during sleep, when breathing often becomes more shallow and irregular. however, although these devices have become the standard of therapy in als patients once their lung function worsens, it remains unclear how effective these devices actually are when a patient is sleeping, partly because of the practical difficulties in applying the device properly and keeping it applied throughout the sleep period, and partly because they are most commonly prescribed without objective evidence regarding how much breathing support the patient needs as the disease progresses and the breathing muscles weaken further.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of amyotrophic lateral sclerosis (el escorial criteria) * age 18 to 18 years old * using nocturnal noninvasive ventilation to treat respiratory insufficiency at least 4 hours per night, for at least 4 nights per week exclusion criteria: * inability to safely use nippv because of bulbar dysfunction * indications for tracheostomy assisted ventilation due to inability to clear secretions from the airway * presence of comorbid conditions with a life expectancy \< 6 months * presence of advanced dementia * unwillingness to follow up at the eleanor and lou gehrig als/mda center at columbia university on a regular basis * previously diagnosed obstructive sleep apnea * residence outside the new york metropolitan area.

Keywords: noninvasive ventilation
comparison of balance, activity-specific balance confidence and quality of life in parkinson's patients

Conditions: Idiopathic Parkinson's Disease

Summary: parkinson's disease is characterized by cardinal motor signs and motor freezing, gait, posture and balance disorder. about 80% of the causes of falls in parkinson's patients are due to postural instability and motor freezing, and patients' quality of life is significantly affected. loss of balance and falls, which are frequently experienced in parkinson's patients, cause individuals to feel insecure during activities. it is thought that the quality of life of pd patients whose movements are restricted due to the fear of falling may also be negatively affected. the neutrophil/lymphocyte ratio is a marker of peripheral inflammation. the relationship of peripheral inflammation to balance, activity-specific balance confidence, and quality of life in individuals is unclear. the aim of this study was to compare balance, activity-specific balance confidence, quality of life, and the relationship between neutrophil/lymphocyte ratio in parkinson's patients with and without freezing.

parkinson's disease is characterized by cardinal motor signs and motor freezing, gait, posture and balance disorder. about 80% of the causes of falls in parkinson's patients are due to postural instability and motor freezing, and patients' quality of life is significantly affected. loss of balance and falls, which are frequently experienced in parkinson's patients, cause individuals to feel insecure during activities. it is thought that the quality of life of pd patients whose movements are restricted due to the fear of falling may also be negatively affected. the neutrophil/lymphocyte ratio is a marker of peripheral inflammation. the relationship of peripheral inflammation to balance, activity-specific balance confidence, and quality of life in individuals is unclear. the aim of this study was to compare balance, activity-specific balance confidence, quality of life, and the relationship between neutrophil/lymphocyte ratio in parkinson's patients with and without freezing. a total of 20 parkinson's disease age of older the 50 participate in the research. participants were divide into two groups with and without freezing.

Eligibility criteria:
inclusion criteria: * being diagnosed with idiopathic parkinson's disease * healthy individuals who do not have musculoskeletal disease or any neurological disease that may affect assessments * older than 50 years old * volunteer to participate in the study * grade 1-3 on the modified hoehn-yahr scale * to have a score above 24 in the standardized mini mental test * to have a hemogram follow-up in the last 1 month before the date of participation in the study. * being able to walk independently on flat ground exclusion criteria: * having an additional or psychiatric disease other than parkinson's disease * lack of cooperation * presence of orthopedic problems (such as fractures, osteoporosis, osteomyelitis)

Keywords: parkinson's disease balance balance confidence quality of life freezing neutrophil/lymphocyte ratio
the effect of self-management skills training given to nursing students according to peer education module on problematic internet use and academic procrastination behavior

Conditions: Problem Behavior; Problematic Internet Use; Academic Procrastination Behavior

Summary: the aim of the study is to evaluate the effect of self-management skills training given with the peer education module on the problematic internet use and academic procrastination behavior of nursing students. .

a total of 12 hours of self-management skills training will be given to the peer groups, two days a week for three weeks, two lesson hours a day (60 min. + 60 min.).the effect of self-management skills training on problematic internet use and academic procrastination behavior of nursing students will be evaluated.

Eligibility criteria:
research inclusion criteria; * being 18 years or older, * volunteering to participate in the study, * using the internet for an average of 2 hours or more per day, * not having any communication problems, * to continue self-management skills training. criteria for exclusion from the research; * having any communication barrier, * not continuing self-management skills training.
"ultra-high frequency intraoral ultrasonography of the tongue" (houston)

Conditions: Oral Squamous Cell Carcinoma

Summary: oral diseases are currently diagnosed by means of clinical examination and supported by surgical biopsy procedures. in particular, daily oral medicine practice is lacking the use of a routine diagnostic support to the visualization of anatomical structures located beyond the mucosal surface. considering the growing interest in minimally invasive diagnosis, the possibility of having an imaging technique dedicated to the investigation of oral soft tissues and their alterations may be instrumental to support the clinical diagnosis. therefore, attempts to introduce conventional ultrasonography (us) to the diagnostic work-up of pathological conditions of the head and neck have been done, exploiting the unique features of this technique in terms of limited invasive- ness, repeatability, and cost efficiency. in the literature, both extraoral and intraoral applications of us have been reported. extraoral applications mainly focus on the characterization of oral and maxillofacial swellings of various origin, while intraoral applications mostly involve the study of malignant lesions in terms of tumor thickness and depth of invasion. the aim of the present protocol is to evaluate the role of intraoral ultra-high frequency ultrasonography in the study of oral mucosal lesions.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of oral squamous cell carcinoma * eligibility for surgical treatment * acceptance to be included in the study exclusion criteria: * oral lesions other than oral squamous cell carcinoma * pregnant or breastfeeding patients * uncontrolled chronic diseases and/or conditions hindering the participation in the study * denial of inclusion in the study

Keywords: oral neoplasm ultrasonography depth of invasion
myostrain cmr testing of ischemia with low levels of stress

Conditions: Coronary Artery Disease; Myocardial Ischemia; Myocardial Dysfunction

Summary: this prospective, observational study evaluates the accuracy of stress testing with the myostrain senc cmr imaging system to detect myocardial ischemia and viability in patients with suspected coronary artery disease using low levels of stress.

this prospective, single center study evaluates the myostrain senc cmr imaging system for the detection of myocardial ischemia and viability during conventional cardiac magnetic resonance (cmr) wall motion stress testing. patients with known or suspected coronary artery disease and scheduled for cardiac catheterization will be consented for inclusion in the study and evaluated during stress testing with low dose dobutamine as the stressor agent. data obtained with the myostrain senc cmr imaging system will be for observational purposes and will not be used to alter patient management.

Eligibility criteria:
inclusion criteria: * known or suspected coronary artery disease * symptoms potentially due to cad; stable angina * positive imaging stress test or negative stress test but typical angina or anginal equivalent * negative troponin with unstable angina * invasive coronary angiography planned within 3 months of cmr * provided written consent exclusion criteria: * pregnancy * contraindication to magnetic resonance imaging * prior allergy to dobutamine * severe aortic stenosis * hypertrophic cardiomyopathy * clinically significant ventricular tachycardia that would prohibit dobutamine administration

Keywords: strain
evaluate the effects of patupilone on the pharmacokinetics of midazolam and omeprazole in patients with advanced malignancies (extension)

Conditions: Solid Tumors

Summary: the purpose of this extension study is to evaluate the potential inhibitory effects of patupilone on metabolism using midazolam and omeprazole as the respective probe drugs.


Eligibility criteria:
inclusion criteria: * male or female patients 18 years or older * histologically documented advanced solid tumor, who have failed standard systemic therapy, or for whom standard systemic therapy does not exist * completed the core study * completed all sampling in the core and not dose reduced patients with adequate hematologic parameters exclusion criteria: * female patients who are pregnant or breast-feeding. * patients with a severe and/or uncontrolled medical disease * patients with a known diagnosis of human immunodeficiency virus (hiv) infection * patients having received an investigational agent within 30 days prior to study entry other protocol-defined inclusion/exclusion criteria may apply

Keywords: cancer epo906 patupilone
efficacy of bimatoprost 0.03% in patients who are low-responders to latanoprost

Conditions: Glaucoma

Summary: to evaluate the iop-lowering efficacy of bimatoprost 0.03% in patients found to be low-responders to latanoprost therapy.


Eligibility criteria:
inclusion criteria: * · male or female \> 18 years of age * documented low-responder to latanoprost therapy as delineated in the outline above. * diagnosis of open-angle glaucoma or ocular hypertension * ability to provide informed consent and likely to complete all study visits exclusion criteria: * · known contraindication to bimatoprost or any component of any study medication * uncontrolled systemic disease * active ocular disease other than glaucoma or ocular hypertension * required use of ocular medications other than the study medications during the study (intermittent use of artificial tear solutions will be permitted) * history of intraocular surgery within the last 3 months
safety and efficacy study of cinryze for prevention of angioedema attacks in children ages 6-11 with hereditary angioedema

Conditions: Hereditary Angioedema (HAE)

Summary: primary objective - to assess the relative efficacy of two dose levels of cinryze (500 units and 1000 units) administered by intravenous (iv) injection every 3 or 4 days to prevent angioedema attacks in children 6 to 11 years of age with hereditary angioedema (hae). secondary objectives - to assess the safety and tolerability, characterize the pharmacokinetics (pk) and pharmacodynamics (pd), and assess the immunogenicity of two dose levels of cinryze administered by iv injection in children 6 to 11 years of age with hae.


Eligibility criteria:
inclusion criteria: * diagnosis of type i or type ii hae. * history of angioedema attacks. exclusion criteria: * history of bleeding or clotting abnormality. * diagnosis of acquired angioedema or known to have c1 inh antibodies. * history of allergic reaction to c1 esterase inhibitor or other blood products. * receipt of any experimental agents other than those required for prevention or treatment of angioedema attacks within 30 days prior to screening.

Keywords: pediatric c1 inhibitor hae cinryze c1 inh prevention
the effects of dark chocolate on blood pressure in individuals with mildly elevated blood pressure

Conditions: Blood Pressure

Summary: the evidence linking chocolate with lowered blood pressure has been observed. however, the interventions have been short, at most 4 weeks. the aim of this study is to find out if the habitual consumption of dark chocolate for 8 weeks has an effect on blood pressure. also, more insight to the mechanisms linking chocolate to individual healt-responses is needed.


Eligibility criteria:
inclusion criteria: * age 25-65 years * resting systolic pressure 140-159 mmhg or diastolic blood pressure 90-99 mmhg * bmi 25.0- 29.9 exclusion criteria: * smoking * regular medication for hypertension, cardiovascular disease, diabetes or asthma

Keywords: cocoa dark chocolate hypertension blood pressure monitoring, ambulatory flavanols
preemptive and postoperative intra-articualr injection of levobupivacaine and tramadol

Conditions: Pain After Knee Arthroscop

Summary: comparison between preemptive and postoperative intraarticular injection of tramadol on pain sensation after arthroscopy

220 patients assigned for therapeutic knee arthroscopy were divided into four equal groups in this prospective comparative study. all patients received iai of 20 ml (0.5%) levopubivacaine alone in group c; with 100 mg tramadol as pe (group pe), at end of surgery (group po) or divided as 50 mg tramadol + 20 ml 0.25 % levobupivacaine as pe and 50 mg trmadol + 20 ml 0.25 % levobupivacaine as po (group pe/po). numeric rating scale (nrs) was used to assess pain sensation. duration till request of rescue analgesia and number of requests were recorded. patients' satisfaction concerning efficacy of po analgesia was assessed using iowa satisfaction with anesthesia scale.

Eligibility criteria:
inclusion criteria: * patient physical status according to american society of anesthesiology (asa) classes i-ii * patients free of general diseases prohibiting the use of local anesthesia. exclusion criteria: * patients had allergy for local anesthetics or to tramadol * patients have psychological or neurological disorders inducing difficulty for evaluation of pain scoring.

Keywords: tramadol intra-articular injection preemptive post-arthroscopy pain levobupivacaine
penpulimab combined with rma treatment of primary diagnosis of primary central nervous system lymphoma

Conditions: Primary Central Nervous System Lymphoma

Summary: to explore pfs, orr (cr/cru+pr), os and side effects of piamprizumab combined with rma in newly diagnosed pcnsl, so as to clarify the value of piamprizumab combined with rma in the first-line treatment of pcnsl patients, and to clarify the clinical and biological factors affecting the efficacy


Eligibility criteria:
inclusion criteria: * for initial pcnsl confirmed by pathological tissue, the diagnostic criteria were based on who diagnostic criteria in 2016 * head mr (plain scan + enhancement) performed 28 days prior to study enrollment should show the presence of at least one measurable lesion in two vertical directions (according to 2014 lugano criteria); or abnormal cerebrospinal fluid examination (including cerebrospinal fluid protein, cells, ngs), or ophthalmologic examination confirmed the retina, vitreous lesions * ps score was 0\~4 according to ecog exclusion criteria: * organs or lymph nodes outside the central nervous system are involved * patients with a second primary tumor (other than non-melanoma skin cancer in situ, superficial bladder cancer, cervical cancer in situ, gastrointestinal intramucosal cancer or breast cancer that has been cured and has not recurred within 5 years) * has a history of allergic disease, severe drug allergy, or is known to be allergic to any component of a macromolecular protein preparation or penpulimab injection prescription * prior treatment with anti-pd-1 antibody, anti-pd-l1 antibody, anti-pd-l2 antibody, anti-ctla-4 antibody, or car t cell therapy (or any other antibody that acts on t cell co-stimulation or checkpoint pathways) * a severe acute or chronic infection requiring systemic treatment * the investigator believes that the subjects may have other factors that affect the efficacy or safety evaluation of the study
psychodynamic psychotherapy for psychosis

Conditions: Psychotic Disorders

Summary: the broad goals of our pilot study are to (1) determine whether psychodynamic psychotherapy for psychosis (ppfp), relative to treatment as usual (tau), can maintain or augment clinical and functional benefits for patients who have achieved initial recovery in our coordinated specialty care (csc) early psychosis treatment program; (2) to conduct novel empirical study of how various psychodynamic factors may inform candidate selection, mediate therapeutic effects, and influence relational aspects of the therapy; and (3) to conduct a detailed study of how features of therapist and patient speech and behavior influence therapeutic outcomes, therapeutic alliance alliance, and relational process. this registration focuses on the first goal.


Eligibility criteria:
inclusion criteria: * completed the 2-3 year coordinated specialty care (csc) program * judged by present provider to be in an intermediate or advanced phase of recovery * had first episode of psychosis within the 3 years prior to enrollment exclusion criteria: * established diagnosis of primary affective disorder, psychosis secondary to substance use or a medical illness * inability to communicate in english * eligibility for department of developmental services * legally mandated to enter treatment.