Kornimate/medical-research-clean huggingface dataset:
impact of the covid-19 on rsv

Conditions: Rhinovirus; RSV Infection

Summary: the magnitude of seasonal rsv epidemics brings each year new logistical challenges for the hospitalization of young infants with bronchiolitis that overwhelm hospital capacities and lead to specific winter plans with deprogramming and mobilization of human and logistical resources. the covid-19 pandemic has changed the way winter epidemics are presented. for example, the seasonal rsv epidemic was shifted by several months in lyon, with an impression of a lower incidence of hospitalized cases, with a population of older children and with fewer signs of clinical severity. this is largely attributable to the widespread use of barrier gestures and social distancing measures, known as "non-pharmacological interventions" or npi. given the magnitude of the reduction of the rsv epidemic, it is legitimate to analyze the benefits of npis to draw lessons for maintaining preventive measures around rsv-vulnerable populations; moreover, new preventive pharmacological interventions are soon to be marketed, whether they are particularly refined and long half-life anti-rsv monoclonal antibodies, rsv vaccines for mothers or for newborns and infants. in this perspective, it is crucial to properly define the populations at risk of severe disease to establish a legitimate hierarchy in the implementation of different preventive strategies. the study of the rsv epidemic is a high potential model because of the convergence of epidemiological, virological, and pharmacological knowledge. however, the study of the impact of the pandemic on the epidemiology of rhinovirus also seems promising because, for reasons unknown to date, it seems that the pandemic did not have the same reducing impact on the rhinovirus epidemic; in the latter case, the interest is to confirm the resistance of this virus and to look for more fundamental explanations, for example, on viral interactions. on a previous study (see ntc 04944160), 519 infants and children were recruited in the pre-covid-19 season population, and 277 infants and children were recruited in the first per-covid-19 season population. in the present study, the objective is to assess the epidemiology of rvs in infants from the birth cohorts of the tertiary teaching hospitals of lyon, france, during the pre-covid-19 (2013-2020) and the per-covid-19 (2020-2025) years.


Eligibility criteria:
inclusion criteria: * child hospitalized at " hôpital femme mère enfant ", lyon, france * positive rsv-pcr exclusion criteria: * • parent's refusal to participate

Keywords: rsv epidemic covid-19 rsv interaction children non-pharmacological-interventions bronchiolitis asthma pneumonia infants
maxillary sinus elevation and perioperative complications

Conditions: Maxillary Sinus Augmentation

Summary: this study aims to investigate the effects of various external sinus lifting techniques on patient comfort and perioperative complications.

patients who met the inclusion criteria and were admitted for posterior maxilla rehabilitation participated in this prospective, randomized, controlled clinical trial. the three methods used to lift the sinuses were randomized: piezosurgery using a surgical guide, a drill specifically made for lateral sinus lift, and traditional drills. recorded were the duration of the procedure, accessibility, and intraoperative complications. during the first week following surgery, analgesic intake and pain using a visual analog scale (vas) were assessed assessed. preoperatively and on the second and seventh postoperative days, edema was assessed. preoperatively and on the seventh postoperative day, the patient\&#39;s quality of life using the ohip-14 questionnaire, experiences, and expectations were evaluated.

Eligibility criteria:
inclusion criteria: 1. severe resorption or sinus pneumatization in the posterior maxilla that prevents standard implant treatment; class v or vi according to cawood and howell classification, patients with residual bone height less than 6 mm 2. patients over 18 years of age 3. patients without a history of reconstructive pre-prosthetic surgery or previous implant surgery 4. patients with partial edentulism who have applied to our center for implant treatment and need sinus lifting 5. patients with cone beam computed tomography (cbct) taken within the last 1 month exclusion criteria: 1. patients with a history of systemic diseases (hematologic, neurologic, etc.) that may be contraindicated surgery 2. patients who are pregnant or in lactation period 3. patients with a history of immune system disorders and substance abuse 4. patients with a history of radiotherapy in the head and neck region 5. patients with existing maxillary sinus pathology or who have undergone surgery 6. patients who smoke \&gt;10 cigarettes per day 7. patients using antibiotics or steroids in the 30 days before surgery 8. uncooperative patients who do not comply with the study protocol or follow-up regimen 9. patients with perforation of the schneiderian membrane

Keywords: sinus floor augmentation computer-aided design piezosurgery
incidence of hypoglycaemia events in patients with stable insulin-treated type 2 diabetes mellitus based on continuous glucose monitoring

Conditions: Diabetes Mellitus Type 2 With Hypoglycemia

Summary: certain groups of patients with type 2 diabetes mellitus (t2dm) appear to have higher risk of hypoglycaemia. periodic use of continuous glucose monitoring (cgm), has been suggested as a method to detect hypoglycaemia events in certain subgroups of patients with high risk of hypoglycaemia. the aim of the present study is to contribute to the identification of subgroups of t2dm patients with high risk of hypoglycemia events, based on periodic use of continuous glucose monitoring (cgm).

some studies successfully achieved standard glycemic targets without increased hypoglycaemia in older adults and other groups of patients with high risk of hypoglycaemia events. however these trials usually exclude adults with poor health and comorbidities, when they support the concept that intensive strategies for selected individuals can be effective and safe. the compendium of results from these and other published analyses suggests that although some patients may benefit from tighter targets, many are unable to reach these targets, and aggressive therapy may be harmful to some patients without the benefit of reducing complications. although avoidance of hypoglycaemia is a critical treatment strategy, overall glucose control remains an important goal. the present treatment guidelines fail to locate the proper subgroup of patients with type 2 diabetes mellitus (t2dm), that could be benefited of glycemic control balanced with the adverse effects of glucose-lowering medications and a patient's age, overall health status, and functional and intellectual capacity. the aim of the present study is to contribute to the identification of subgroups of t2dm patients with high risk of hypoglycemia events, based on periodic use of continuous glucose monitoring (cgm).

Eligibility criteria:
inclusion criteria: * being older than 40 years of age * having type 2 diabetes for at least 1 year * being on insulin therapy for at least 3 months before recruitment * having the ability to perform self-monitoring * being able to wear a cgm system during 2 weeks * having a stable metabolic situation, defined as having no need to add new treatments or make any changes in insulin dosage of more than 10% in the preceding 2 months exclusion criteria: * having severe hearing or vision problems or any other acute or chronic condition that would limit the ability of the user to participate in the study * being institutionalised or person not capable of giving consent * pregnancy
outcomes of social service programs for homebound older adults

Conditions: Homebound; Elderly

Summary: the objective of this prospective study is to document the impact of social service interventions (including meals, telephone reassurance, and friendly visiting)provided by the burden center, a model community social service agency, on overall quality of life.

specific outcomes include mental and physical function as measured by the sf-36, and depressive symptoms as measured by the ces-d depression scale. the hypothesis is that a multicomponent social service intervention program that provides social support and reduces social isolation can prevent depression and decline in quality of life in this vulnerable population.

Eligibility criteria:
inclusion criteria: * all new clients of the burden center for the aging who are homebound, out of the home less than one time per week, and cognitively intact will be eligible for enrollment. exclusion criteria: * clients unable to give informed consent such as those suffering from a major psychiatric disease or those who are not cognitively able to give informed consent will be excluded. * clients who refuse to participate will be excluded

Keywords: social service intervention social support elderly homebound quality of life
serum gper-1 and oxidant/antioxidant levels on retinopathy in diabetic patients

Conditions: Diabetes Mellitus; Diabetic Retinopathy; Hormones

Summary: observational, comparative, cross-sectional study

this study was conducted on g protein-mediated estrogen receptor 1 (gper-1), which is thought to be effective in preventing the development of diabetic retinopathy (dr). there are studies proving that gper-1 prevents neuroprotective effects and vascular pathology in many tissues. in the study, serum gper-1 and oxidative stress biomarker levels were compared in diabetic patients and healthy control groups. gper-1 was found to be significantly increased in diabetic patients. in addition, a positive correlation was found with oxidant markers. this may lead to new treatment models in the future.

Eligibility criteria:
inclusion criteria: * 40 individuals were required to have proliferative diabetic retinopathy (pdr); * 40 were required to have non-pdr; * 40 were required to be healthy, without any systemic disease. exclusion criteria: * glaucoma, * ocular trauma sequelae, * pathological myopia, * non-diabetic retinopathy, * a history of previous ocular surgery, * endocrine disorders (e.g.,thyroidopathy, adrenal gland disorders, pituitary pathologies), * opacities interfering with fundus examination (e.g., corneal opacity, lens opacity, vitreous cloudiness other than diabetic haemorrhage).

Keywords: diabetic retinopathy gper-1 oestradiol progesterone tsh oxidative stress neuronal damage.
icotinib as the adjunctive treatment after surgery in stage i-iiib lung adenocarcinoma patients with egfr gene mutation

Conditions: Neoplasms, Therapy-Associated

Summary: this is a randomized ,opened, prospective controlled trial of clinical effectiveness for icotinib as the adjunctive treatment after surgery in stage i-iiib lung adenocarcinoma patients with epidermal growth factor receptor gene mutation

in this trial the investigators will enlist 100 patients who accepted surgery and with epidermal growth factor receptor gene mutation,these patients will be divided into 2 groups (chemotherapy group and icotinib group),compare the pfs,rfs,os after 5 years follow up

Eligibility criteria:
inclusion criteria: * 18-75 years old * lung adenocarcinoma patients with epidermal growth factor receptor gene mutation,stage i-iiib after surgery * the patients' eastern cooperative oncology group scores are ≤ 0-2 exclusion criteria: * mismatch conditions above * have used other anti-cancer therapy drug before the trial and may influence the outcome
vats evacuation compared to reinsertion of thoracostomy tube in persistent traumatic haemothorax

Conditions: Hemothorax; Traumatic

Summary: this is prospective, randomized study comparing vats (video- assisted thoracoscopy) to reinsertion of a thoracostomy tube in patients with persistent traumatic haemothorax. the incidence varies and can be as high as 20%, but in most studies is found to be 1-4% after initial tube thoracostomy for chest trauma. the most accepted complication of retained hemothorax is empyema.retained hemothorax treatment started by physiotherapy and early withdrawal of tube thoracostomy which lead to more complications as empyema, fibro thorax/entrapped lung, flail chest and diaphragmatic hernia. early vats is an alternative treatment for retained hemothorax with evidence that it is a superior intervention when compared to a second tube thoracostomy.

traumatic injuries are a significant cause of morbidity and mortality in our society.at assiut university hospitals, chest injuries (17.7%) considered as second cause of mortality after head injuries (34.6%) of registered deaths by cause of injury at trauma unit, assiut university hospitals in a study conducted between,2002-2009. in united states, thoracic injuries are the primary factor in approximately 35% of these deaths, one -third of which occur immediately following the injury, and are contributing in nearly 75% of trauma -related deaths. up to 15% of patients who sustain thoracic trauma undergo emergent thoracotomy for resuscitation, massive hemothorax, cardiac tamponade, large thoracic wounds, major thoracic vascular injuries, tracheobronchial injuries, or evidence of esophageal injury. the remaining 85-90% of patients who reach the emergency department does not require emergent thoracotomy are initially managed with tube thoracostomy, pain control, pulmonary toilet, and observation .patients failing this management ultimately require elective thoracotomy for further evaluation and treatment(clotted hemothorax, empyema and diaphragmatic hernia. the current role of vats in trauma includes evaluation and control of continued chest tube bleeding, early evacuation of retained hemothorax, evacuation and decortication of posttraumatic empyemas, evaluation and limited treatment of suspected diaphragm injuries, evaluation and treatment of persistent air leaks, and evaluation of mediastinal injuries.

Eligibility criteria:
inclusion criteria: we include for the study all patients admitted to assiut university hospitals during the time of the study that proved persistent haemothorax that with criteria: 1. ages that are eligible for study are between 18years to 60 years (adult) 2. both genders will be included to study. 3. clinical and radiological diagnosis of persistent haemothorax. 4. thoracostomy tube blockage or failure to drain within 5-7days. exclusion criteria: 1. more than one thoracostomy tube drainage in the same attempt side. 2. unable to consent to trial. 3. coexisting pathology requiring other interventions. 4. patients that need urgent interventions (hemodynamically unstable, empyema and flail chest).
covid-19 personal protective equipment for vaccinated health workers and convalescents

Conditions: Covid19

Summary: the aim of the trial is to assess the safety of using simplified personal protective equipment (ppe) for vaccinated or covid-19 convalescent healthcare workers working in covid-19 icu or covid-19 wards. the trial is designed as a prospective randomized observational trial with volunteer medical staff working in covid-19 departments aiming to show non-inferiority of simplified ppe vs standard covid-19 ppe.

objectives to assess safety of simplified personal protective equipment (ppe) for vaccinated health workers and covid-19 convalescents - pilot trial. methods prospective randomized observational trial. 60 participants randomized 1:1 to either standard ppe (covid-19 ward: ffp2 or higher respirator, goggles of face shield, gown, gloves; covid-19 icu: ffp3 respirator and tight goggles or full face mask or powered air-purifying respirators, gown and gloves) or simplified ppe (surgical mask, goggles or face shield, gown). 30 days follow up period. participants volunteer medical staff from covid-19 regular and icu departments at university medical center ljubljana, slovenia, with either proven covid-19 infection within 6 months or at least 7 days after second dose anti coivd-19 vaccine. hypotheses simplified ppe is non-inferior to standard ppe in vaccinated health workers or convalescents. discussion positive study results may decrease ppe spending cost and positively affect working conditions at covid-19 departments.

Eligibility criteria:
inclusion criteria: * age \< 50 years * prior covid-19 infection; time from infection \< 6 months. * prior completed anti covid-19 immunization; \> 1 week post second dose of immunization. * signed written consent * negative nasopharyngeal covid-19 rt-pcr test exclusion criteria: * age \> 50 years * time post covid-19 infection \> 6 months * time post covid-19 immunization \< 1 week. * immunocompromised patients * pregnancy * ckd 3 or more * copd or other lung disease * heart failure of any cause * ischemic heart disease * obesity (bmi \> 30) * dm on therapy

Keywords: covid19 sars-cov 2 personal protective equipment safety
the influences of early mobilization on myokines, body composition and outcomes in icu septic patients

Conditions: Sepsis

Summary: the investigators' preliminary data revealed that early physical therapy in patients with sepsis in icu could promote recovery of function (liver and kidney) and decrease the length of stay in hospitalization. the levels of plasma il-6 and il-10 were higher in non-survival group than in survival group. the investigators hypothesize that myokines and body composition parameters are related to the prognosis of sepsis.the investigators will investigate the influences of duration and intensity of early mobilization on myokines, body composition and outcomes of septic patients in intensive care. the proposed study can help precision medicine in the future.

the septic patients admitted to the intensive care unit (icu) will be divided into three groups. one is non-pt group, with no physical treatment intervention (group 1), early-pt group with physical treatment intervention started in icu admission day 3 (group 2), and delayed-pt with physical treatment intervention started after icu admission day 3 (group 3). the grouping will be based on clinical indication for early mobilization (physical therapy) as below. the body composition data (of day 1, 3, 8) of the patients in the three groups will be measured, and the residual blood from day 1 and day 8 will be collected for detecting myokines.

Eligibility criteria:
inclusion criteria: * 1. aadmission in icu 2. clinical diagnosis of sepsis exclusion criteria: * 1. expired in 3-days 2. cardiac stents or pacemakers 3. airborne disease 4. contact-transmitted disease

Keywords: sepsis early mobilization myokines body composition
tranexamic acid in pregnancies with vaginal bleeding

Conditions: Vaginal Bleeding During Pregnancy

Summary: tranexamic acid has been proposed and used for prevention and management of antepartum and postpartum hemorrhage.

bleeding during pregnancy is associated with a three- to fourfold increase in perinatal mortality. hemorrhage in pregnancy is characterized by activation of the fibrinolytic system. tranexamic acid is a potent pharmaceutical agent that suppresses fibrinolysis, and thus can be used for managing hemorrhage in pregnancy. the fda's pregnancy category for tranexamic acid is category b. tranexamic acid has been used to decrease blood loss and treatment of intra partum blood loss in cesarean section also it has been used for prevention and management of postpartum hemorrhage after vaginal bleeding, regardless of whether the bleeding is due to genital tract trauma or other causes.

Eligibility criteria:
inclusion criteria: * pregnant woman having vaginal bleeding * second and third trimester of unknown etiology * no placenta previa, abruptio placentae, local cervical or vaginal causes for bleeding * primigraivid, multiparous and grand multiparous woman * accept to participate in the trial exclusion criteria: * hypersensitivity to tranexamic acid * women with acquired defective color vision * history of venous thromboembolism * refused to participate

Keywords: antepartum bleeding perinatal morbidity perinatal mortality preterm labor
study to evaluate the efficacy and safety of dwp14012 in patients with erosive gastroesophageal reflux disease (phase 2, therapeutic exploratory study)

Conditions: Erosive Gastroesophageal Reflux Disease

Summary: the purpose of this study is to determine the efficacy and safety of dwp14012 compared to esomeprazole in the treatment of erosive gastroesophageal reflux disease classified as los angeles(la) classification grades a to d.


Eligibility criteria:
inclusion criteria: * adults between 20 and 75 years old based on the date of written agreement * those who have been diagnosed with erosive gastroesophageal reflux disease(egrd) of la grade a-d on the upper gastrointestinal endoscopy * those who experienced symptoms of heartburn or acid reflux within the last 7 days exclusion criteria: * those who have undergone gastric acid suppression or gastric, esophageal surgery * those who with clinically significant liver, kidney, nervous system, respiratory, endocrine, hematologic, cardiovascular, urinary system disease
exploration on the value of mrd based on ctdna detection in predicting recurrence of resected non-small cell lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: based on the unique patented monod and methyl titan methylation sequencing technology on lung cancer tissue and blood samples, a lung cancer mrd monitoring panel is designed. the panel is used to detect molecular residual disease of stage ib-iiib non-small cell lung cancer patients underwent radical surgery, explore personalized analysis models, and conduct research on recurrence monitoring for non-small cell lung cancer patients.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years old, regardless of gender; 2. patients with pathological diagnosis of non-small cell lung cancer and clinical staging of stage ib-iiib; 3. able to undergo radical surgical treatment; 4. physical condition score (ecog) ≤1; 5. the expected survival time exceeds 24 months; 6. volunteer to participate in this study and sign an informed consent form. exclusion criteria: 1. individuals with a history of other malignant tumors within 5 years; 2. those who have undergone neoadjuvant therapy before surgery; 3. postoperative incision margin r1 or incision margin r2; 4. those who have undergone a blood transfusion within 2 weeks before the surgery; 5. individuals with systemic inflammatory response syndrome; 6. those with serious diseases of important organs such as the heart, lungs, kidneys, and brain; 7. participants in other clinical trials within the past 30 days and have taken investigational drugs; 8. due to various reasons, sampling cannot be completed, samples do not meet the requirements, or baseline samples (preoperative and postoperative plasma samples, tumor tissue samples) are incomplete; 9. researchers believe that it is not appropriate to participate in this experiment.
extracorporeal shock wave versus local corticosteroid injection for carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome; Shock Wave

Summary: this rct is to investigate the clinical effect of extracorporeal shock wave therapy (eswt) compared to the local corticosteroid injection (lci) in managing mild to moderate carpal tunnel syndrome (cts).

to investigate the effect of extracorporeal shock wave therapy (eswt) compared to the local corticosteroid injection (lci) in managing mild to moderate carpal tunnel syndrome (cts). about 50-60 patients with mild to moderate cts are supposed to be randomly allocated into either eswt group or lci group. the outcomes include the visual analog scale (vas), the boston carpal tunnel questionnaire (bctq), and nerve conduction study at baseline and at 3 weeks, 9 weeks, 12 weeks, 6 months, and 12 months after the treatments.

Eligibility criteria:
inclusion criteria: the patients aged ≥18 years 1. should present a new episode of cts with symptoms lasting for ≥ six weeks 2. symptoms include wrist pain, numbness, and paraesthesia on the hands 3. tested postive by the phalen test and tinel test 4. electrodiagnostically diagnosed with mild to moderate cts exclusion criteria: 1. a lack of consent information 2. a history of a cts surgery or lci in the carpal tunnel 3. asystemic disease that may interfere with the study