Kornimate/medical-research-clean huggingface dataset:
apolipoprotein e gene and functional mri

Conditions: Dementia

Summary: 1. apolipoprotein e gene (apoe) is the most important genetic factor for alzheimer disease (ad) and an important genetic factor for outcome of brain injury situations. 2. function magnetic resonance imaging (fmri) is a powerful tool for study of both brain regional functions and brain network. 3. study about genetic contribution on fmri is an emerging concept, which will help on understanding about how the genetics affecting the brain function.

there are about 4-10% people aged and over 65 years suffering from dementia in taiwan. dementia caused by diverse diseases, including alzheimer's disease (ad), fronto-temporal dementia (ftd), dementia with lewy body (dlb), parkinson's disease dementia (pdd) and vascular dementia (vad), is a neurodegenerative disease characterized by memory impairment, cognitive dysfunctions, behavioral disturbances and various kinds of psychiatric manifestations. ad is the most common cause of dementia in the world. although the real pathophysiology of ad is still obscure, the compelling evidence has shown genetic factor should play an important role in the occurrence of ad. there are three genes, in terms of amyloid precursor protein (app), presenilin-1 (ps1) and presenilin-2 (ps2), linked in the familial ad. mutations on these genes would result in familial ad, which account for only less than 5% of ad. the only one well-documented genetic risk factor for sporadic ad is apolipoprotein e, ε4 allele (apoe4). apoe gene contains three genetic polymorphisms, ε2, 3, 4 and apoe4 has been found associated with many brain injury situations, such as poor outcome for traumatic brain injury (tbi), parkinson disease dementia (pdd). these findings might support apoe to be important for brain functions but the real mechanisms remain further clarification. functional magnetic resonance imaging (fmri) is a powerful tool for study of both brain regional functions and brain network. to our knowledge, only few reports in top journals indicated genetic background is an important contributor for fmri presentations. this could be a new filed of neuroscience. in this study, we will explore whether apoe genetic polymorphisms affect the presentation of fmri and realize some functions of apoe in the brain. in addition, our data could enhance the new concept about the association between genetics and brain function.

Eligibility criteria:
inclusion criteria: * people aged 45-65 years without cognitive impairment exclusion criteria: * unable to take apoe genotyping or undergo functional mri
comparison of on-site versus off-site evaluation of cholangioscopy-guided biopsies of the bile duct

Conditions: Bile Duct Stricture

Summary: this study will test two different methods for processing biopsy specimens taken from the bile duct. patient;s who are asked to participate int his study have a stricture in the bile duct that needs a single operator cholangioscopy-guided biopsies during endoscopic retrograde cholangiopancreatography (ercp) so that a diagnosis can be made. standard of care includes performing single operator cholangioscopy-guided biopsies in the bile duct and sending the tissue to the lab for testing to make a diagnosis. using this method the investigators can establish a diagnosis only about 50% of the time. the investigators believe that if a cytopathologist is available in the endoscopy suite during the procedure to evaluate the biopsy specimens onsite, the investigators can improve the diagnostic accuracy. the purpose of this study is to compare two methods for processing biopsies obtained from the bile duct (onsite vs. offsite).

the diagnostic accuracy rate of single operator cholangioscopy-guided biopsy is only 50%. this translates to the need for performing repeat procedures to establish a diagnosis and therefore delays patient treatment. the biopsy specimen obtained at cholangioscopy are usually processed offsite in the pathology lab. we believe that if a pathologist can assess the tissue sample during the procedure itself (onsite) and provide feedback, the diagnostic accuracy rate will improve. this translates to better (faster) diagnosis and early treatment. therefore, we will be comparing onsite versus offsite evaluation of bile duct biopsy specimens to determine which method yields a better diagnosis.

Eligibility criteria:
inclusion criteria: * age \> 18 years * suspected biliary stricture exclusion criteria: * age \< 18 years * pregnancy * altered surgical anatomy * irreversible elevation in inr \> 1.5 or low platelet count \< 50,000
study of the combination of anecortave acetate and triamcinolone acetonide for the treatment of exudative age-related macular degeneration (amd)

Conditions: Maculopathy, Age-Related

Summary: the purpose of this study is to evaluate the safety of combining juxtasclerally administered anecortave acetate 15 mg with triamcinolone acetate 4 mg administered intravitreally following photodynamic therapy with verteporfin for the treatment of exudative age-related macular degeneration (amd).


Eligibility criteria:
inclusion criteria: 1. a male or female with evidence of exudative age-related macular degeneration with clinical/angiographic/optical coherence tomography (oct) findings of subfoveal choroidal neovascularization (cnv) which has not responded to current therapy 2. baseline best-corrected visual acuity (bcva) 20/40 to 20/640 3. patient must be willing and able to comply with the protocol and provide informed consent. exclusion criteria: 1. patients on intravenous, subcutaneous, or anticoagulant therapy (with the exception of aspirin and antiplatelet therapy) and cannot take a 5 day holiday from therapy prior to the injection procedure. note: patients on oral anticoagulant therapy may be considered to participate if the physician responsible for monitoring the anticoagulant therapy agrees that the patient may take a 5 day holiday from therapy prior to each anecortave injection. the attending doctor must notify the principal investigator and this notification will be made part of the source documentation. anticoagulant therapy may resume either the evening of or the morning after the injection procedure. 2. patient with known glaucoma or steroid induced ocular hypertension 3. intraocular pressures of 21 mmhg or greater at time of entry into the study 4. patient with significantly compromised visual acuity in the study eye due to concomitant ocular conditions 5. patients who have undergone intraocular surgery within last 2 months or capsulotomy within last month in study eye 6. patient participating in any other investigational drug study 7. inability to obtain photographs to document cnv (including difficulty with venous access) 8. concomitant oral steroids or topical ophthalmic steroid use 9. sub-tenon's injection of steroids within the past 6 months 10. patient with significant liver disease or uremia 11. patient with known adverse reaction to indocyanine green, iodine, verteporfin, or triamcinolone 12. patient is pregnant or nursing 13. age less than 50 years old

Keywords: exudative age-related macular degeneration amd
self-efficacy scale for mothers of premature babies

Conditions: Baby Care

Summary: the aim of this study is to develop a scale to determine the self-efficacy of mothers of premature infants in individualized developmental care practices. this study consists of two stages. in the first stage, it is planned to develop a scale to determine the self-efficacy levels of mothers of premature babies based on individualized developmental care. in the second stage, the scale will be applied. at this stage, families will be trained for individualized developmental care and the effectiveness of the education will be evaluated through the developed scale. for the first stage of the study, it is stated in the literature that at least 5 times the number of items should be taken in determining the sample size during the scale development stage, and 10 times in order to increase the reliability of the scale. in this study, after creating the scale items, a pilot application will be made with 3 mothers. feedback will be received from mothers regarding the clarity of the questions and the scale will be finalized according to the feedback received. then, the scale will be applied to the participant with a size of at least 10 times the number of scale items. for the second phase of the study, firstly, a preliminary application will be made with 10 mothers who meet the inclusion criteria and agree to participate in the study. the number of samples to be taken for the second stage of the research will be determined by performing power analysis with the findings obtained. mothers included in the preliminary application will not be included in the study. it is planned to use stratified block randomization method in the study. first, mothers will be stratified according to their education level and the total number of children they have, then an equal number of (blocking) mothers will be assigned to each group. data will be collected after obtaining written permission from the institution where the research will be conducted. "descriptive information form", "informed voluntary consent form" prepared by the researchers and "individualized developmental care based premature baby mothers' self-efficacy scale" will be used in data collection.


Eligibility criteria:
inclusion criteria: * mothers of premature babies whose babies were discharged from the neonatal intensive care unit (nicu) (training will be given immediately after the baby is discharged), * continuing prematurity of the baby according to the corrected age, * full-time care of the baby at home by the mother, * mothers can speak and understand turkish, * voluntary written and verbal informed consent was obtained from the mothers. exclusion criteria: * being a term baby * the mother has an ongoing psychological diagnosis, * the mothers' unwillingness to continue working at any stage of the study.

Keywords: prematüre mother scale
efficacy of hyaluronic acid injections on functional recovery after surgery for prostate adenoma

Conditions: Prostatic Adenoma

Summary: the purpose of this study is to evaluate the score on urinary function (international prostate score symptom) at 28 days. the main objective is to assess the efficacy of treatment with ialuril® prefill on functional recovery at 4 weeks, based on the international prostate score symptom. a paired test will be performed to compare the international prostate score symptom score between 0 and 28 days.

this is an interventional, non-comparative, open-label, monocentric study aimed at evaluating treatment with hyaluronic acid in patients who have undergone surgery (holep procedure) for prostatic adenoma.

Eligibility criteria:
inclusion criteria: * patient eligible for a holep procedure, according to the investigator ; * patient able to understand the information related to the clinical investigation, to read the information leaflet and agrees to sign the consent form. exclusion criteria: * known intolerance to one of the treatment components: hyaluronic acid, chondroitin sulphate, calcium chloride; * prostatic volume greater than 140 cm3; * patient under anticoagulant treatment for secondary prevention; * patient under guardianship or curatorship, or under a regime of deprivation of liberty; * participating patient, or in a period of exclusion from another clinical trial; * patient not benefiting from a social security scheme.
online hope intervention on mental health literacy among youths in singapore: an rct protocol

Conditions: Mental Health Literacy; Depression Literacy; Psychological Well-being; Stress, Psychological

Summary: the author developed the hope intervention based on a systematic review (tay, tay, \& klainin-yobas, 2018). the overall aim of the study is to test the effectiveness of the online hope intervention in enhancing mental health literacy, depression literacy, psychological well-being and in reducing stress among youths aged 18 - 24 living in singapore.

the study will be a two-group, parallel randomized control trial (rct), with a pre-test, post-test and repeated, control group design. he overall aim of the study is to test the effectiveness of the online hope intervention in enhancing mental health literacy, on depression literacy, psychological well-being and in reducing stress among youths aged 18 - 24 living in singapore.

Eligibility criteria:
inclusion criteria: * : a) students of a particular university in singapore, b) aged between 18 to 24 years old, c) had internet access and d) could read, write and understand the english language. exclusion criteria: * exclusion criteria were reading or hearing disabilities. this was because the online hope intervention consists of written words and videos that require visual and auditory abilities, respectively.
a clinical study on the feasibility and safety of abdominal endoscopic single-port surgery system to assist gynecological day surgery

Conditions: Adenopathy; Uterine Fibroids; Ovarian Cysts; Adnexal Mass; Ovarian Diseases; Adnexal Cyst; Adnexal Diseases

Summary: in this study, a prospective study is used to select patients who will undergo intra-abdominal endoscopic single-port surgery system for benign gynecological diseases from february 2025 to december 2026 in the second affiliated hospital of wenzhou medical university, including hysterectomy, myomectomy, ovarian cyst removal and adnexectomy. the study will perform statistical analysis to evaluate the feasibility and the main factors affecting the safety of intra-abdominal endoscopic single-port surgery system(sr-ens-600) used in gynecological day surgery.


Eligibility criteria:
inclusion criteria: 1. women aged 18 to 75 years old, with a body mass index (bmi) of no more than 32 kg/m2; 2. conscious, no history of mental illness, accompanied by an adult during the perioperative period; 3. educate the subjects, who are willing to undergo day surgery, understand and accept the surgical method and anesthesia method; 4. subjects and families understand perioperative care and are willing and able to complete post-discharge care; 5. elective surgery, no serious complications affecting the operation and prognosis, acci age adjusted comorbidity index 0 points; 6. according to the adhesion risk scoring system of european anti-adhesions in gynaecology expert panel (angel), the adhesion risk was divided into three levels: high, medium and low. subjects with low risk (0 to 12 points) and abdominal wall scarring and pelvic cavity b-ultrasonography do not indicate obvious pelvic cavity adhesion wiil be included. exclusion criteria: 1. moderate and high-risk patients will be excluded based on angel adhesion risk scoring system; 2. subjects with hemorrhagic rupture of ectopic pregnancy and unstable vital signs; 3. genital tract infection or in the acute phase of systemic infection; 4. subjects on long-term anticoagulant therapy or with coagulation dysfunction; 5. subjects have severe heart and lung disease, liver and kidney dysfunction, and cannot tolerate anesthesia; 6. a history of abdominal or diaphragmatic hernia, abnormal umbilical cord development, or umbilical surgery; 7. not willing to undergo endoscopic surgery; 8. participated in other drug and device clinical trials within 3 months before surgery.

Keywords: robotic-assisted laparoscopic single-site surgery (r-less) single-port robot system (sprs) day surgery
chemotherapy-related cognitive impairment and acute leukemia

Conditions: Acute Myeloid Leukemia

Summary: this is an ancillary study of an intervention study (nct04570709). the parent study is a single institution, feasibility trial of 20 (10 control and 10 intervention) patients with the primary objective of assessing feasibility, acceptability, and change in pre and post measures of symptoms, function, and quality of life by administering the palliative and collaborative care intervention (pact). we will further assess cognitive function in the patients who participate in the control of the parent study.

the study objective is to observe patient-reported and researcher-assessed cognitive function in adults with acute myeloid leukemia with chemotherapy treatment. we will assess cognitive function using a battery of neuropsychological assessments, patient-reported questionnaire, and semi-structured interviews among participants in control group only. the group assignment will be conducted through parent study (nct04570709). participating in this study will not affect participants' group assignment.

Eligibility criteria:
\[patient\] inclusion criteria: * ≥ 60 years of age * diagnosis of aml * receive 1) low-dose cytarabine or hypomethylating agent (hma) in combination with venetoclax chemotherapy or 2) low-dose cytarabine or hypomethylating agent (hma) in combination with venetoclax chemotherapy and any investigational drugs * have caregiver(s) willing to participate * participate in the parent study (pact study, nct04570709) exclusion criteria: * referred to hospice care \[caregiver\] inclusion criteria: * identified by patient as a caregiver * ≥18 years of age * speak and read english

Keywords: cognitive function
the efficacy of a tart cherry drink for the treatment of patellofemoral pain in recreational athletes.

Conditions: Patellofemoral Pain

Summary: patellofemoral pain (pfp) is the most common chronic pathology in sports medicine and physiotherapy clinics. as pain and inflammation are the main symptoms of pfp, non-steroidal anti-inflammatory and analgesic medications are often utilized to decrease pain and inflammation; however alternative treatments are increasingly being sought due to the cardiovascular and gastrointestinal side effects of traditional pain medications. most researchers advocate conservative treatment, though there is still insufficient clarity regarding the effectiveness of conservative treatment modalities. dietary interventions for pfp have not received any attention in clinical literature, yet there is a growing body of evidence indicating that cherries have significant anti-inflammatory, antioxidant and pain-mediating effects. therefore, the primary purpose of the proposed investigation was to test (using a randomized control investigation) the ability of a tart cherry juice blend to provide symptom relief in recreational athletes with pfp and to understand the biological and mechanical mechanisms behind any changes in pfp symptoms.


Eligibility criteria:
inclusion criteria: * recreationally active * suffering from mild to moderate patellofemoral pain with no evidence of any other condition. exclusion criteria: * rheumatoid arthritis or other systemic inflammatory condition * chronic pain syndrome * corticosteroid medication in last 2 months (intra-articular or oral) * intra-articular injections of hyaluronic acid in the last 9 months * pregnancy * diabetes * food allergies to cherries.
amputation associated factors and prediction model in diabetic foot patients

Conditions: Diabetic Foot

Summary: diabetic foot can lead to adverse consequences such as amputation and death, which seriously endangering the physical and mental health and quality of life for patients. the aim of this study is to assess factors associated with the occurrence of amputation events in the diabetic foot patients based on a retrospective cohort and to construct a prediction model for patients at high amputated risk.

diabetic foot is one of the major complications observed in patients with diabetes. diabetic foot can lead to non-traumatic lower-limb amputation (lla), and is confirmed to be associated with cognitive decline and worsening quality of life. previous studies indicated that diabetics had a 25% lifetime risk of developing diabetic foot, and 14% to 24% of those require amputation. in patients with poor results of conservative treatment, amputation is the main terminal treatment option to avoid the spread of infection. amputation in diabetic foot patients may linked to different causes, including inflammatory, infectious and malignant conditions. a retrospective cohort based on shandong provincial qianfoshan hospital healthcare big data platform is conducted to evaluate the progression and prognosis of diabetic foot patients. a prediction model will be developed to identify high-risk diabetic foot patients of amputation and provide a scientific basis for personalized clinical care.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of diabetic foot * hospitalized patients * no history of amputation exclusion criteria: * patients with bone neoplasms * patients with osteomyelitis not caused by diabetes * patients with amputation caused by severe peripheral vascular disease not caused by diabetes * traumatic amputations * patients in shock on admission * patients discharged against medical advice

Keywords: diabetic foot amputation cohort study predict model
forceps biopsy versus cryo-biopsy in the diagnosis of lung cancer

Conditions: Lung Cancer

Summary: this study was comprised of 30 patients who were scheduled for a diagnostic bronchoscopy due to a suspicion of lung cancer in order to obtain tissue samples for a final diagnosis , four biopsies were taken by each of cryobiopsy and forceps biopsy , to evaluate and compare the diagnostic yield of endobronchial cryobiopsy and forceps biopsy in the diagnosis of lung cancer .

diagnostic bronchoscopic interventions are used to evaluate and tissue sample from endobronchial lesions utilising variety of devices that can be delivered through the operative channel of a fibrio-optic bronchoscope. all of the procedures were carried out with 2% lidocaine instillation and midazolam iv sedation all patients signed a written informed consent form for bronchoscopy and tissue sampling with forceps and a cryoprobe.between august 2020 and june 2021. all interventions were performed in the bronchoscopy unit of the chest medicine department at benha university data were collected, revised, coded and entered to the statistical package for social science (ibm spss) version 23. the quantitative data with parametric distribution were presented as mean, standard deviations and ranges.

Eligibility criteria:
inclusion criteria: * severe uncorrected hypoxemia despite supplemental oxygen treatment * unstable angina * uncontrolled arrhythmias, * severe hypercarbia, * unstable cervical spine. * coagulopathy that cannot be reversed * chronic obstructive pulmonary disease (copd) exacerbation * severe illness * old age * malnutrition * patient who refused to have a bronchoscopy performed exclusion criteria: patients' histories, including age, sex, and smoking status, were documented for all participants in the trial clinical examination and medical history complete blood count, serum creatinine, liver enzymes, inr, bleeding time, and clotting time are all routine laboratory tests plain chest x-ray and chest computed tomography were used in the radiological workup\* arterial blood gas on room air. bronchoscopy and biopsy taking with forceps and cryobiopsy -

Keywords: bronchoscope, cryo-biopsy
tdcs combined with constraint induced movement therapy and role of gaba activity in stroke recovery

Conditions: Stroke

Summary: the aim of this study is to determine whether noninvasive brain stimulation in form of active transcranial direct current stimulation (tdcs) combined with constraint induced movement therapy (cimt) offers an additional benefit as compared with sham tdcs combined with cimt in patients with stroke. furthermore the purpose is to highlight changes in gaba activity more than 3 months after stroke and its importance for effect of tdcs and cimt combined with tdcs.


Eligibility criteria:
inclusion criteria: * stroke onset \>3 months prior to study enrollment * subject has at least 10 degrees mobility over wrist, thumb and fingers on the affected side * subject can move, stand up and stand firmly with constrained healthy hand * subject can perform training 6 hours daily in 2 weeks * subject is able to understand instructions and be able to cooperate exclusion criteria: * pregnancy * contraindications to mri of brain * epilepsy, major psychiatric disease * excessive pain that prevents training * history of other diseases resulting decreased mobility of affected upper limb