Kornimate/medical-research-clean huggingface dataset:
the effects of hesperidin and flaxseed in prediabetes

Conditions: PreDiabetes

Summary: to study the effects of hesperidin and flaxseed supplement in patients with prediabetes, 50 patients will be randomly allocated to control group or 2 capsules hesperidin and 30 gram flaxseed for 12 weeks; both groups will be advised to adherence the investigators' diet and exercise program too. at the first and the end of the intervention, lipid profiles, blood pressure, blood sugar, inflammatory and anthropometric factors will be assessed and compared between groups.


Eligibility criteria:
inclusion criteria: * age of 18 to 70 years prediabetes: impaired fasting glucose (\>100 mg/dl) and/or hba1c 5.7% to 6.5%, and overweight or obese with body mass index range of 25 to 40 kg/m2 exclusion criteria: * pregnancy or lactation * a history of cardiovascular disease, pulmonary disease, renal disease \& celiac disease; cirrhosis * following program to lose weight in recent 3 mo
the relax trial: nonpharmaceutical intervention for nocturnal muscle cramps

Conditions: Cramps; Muscle Cramp

Summary: the purpose of the study is to learn about reducing the symptoms and severity of nighttime lower body muscle cramps in patients with and without cirrhosis. eligible participants will have an initial 7-day practice phase, followed by 28 days of one of two behavioral interventions.

the interventions in this trial can be done at home. openly discussing the intervention groups with all participants prior to randomization thus poses a high risk of tainting the study because subjects in the one group may start doing the other groups exercises after having heard about it during the consent process as a way to potentially reduce the symptoms and severity of painful muscle cramps. therefore, this study will conceal information regarding the nature of the interventions. only participants randomized to the true intervention group will be told during the study period what the behavioral intervention is. additionally, the title of this trial upon registration is listed slightly differently than it is listed with the institutional review board (irb), to provide scientific integrity with the masking requirements. when the trial is completed, the title will be amended to match the irb approved title. at the conclusion of the study, at the time of the final follow-up assessments, all participants will be debriefed on the use of the concealment of the study object in this study.

Eligibility criteria:
inclusion criteria: * participants have painful muscle spasms, cramps, or charley horses at night in feet or legs. * participants have muscle cramps that happen at least four times in the past month. and the muscle cramps bother them. * for cirrhosis patients only: diagnosis of cirrhosis based upon: 1. liver biopsy, or 2. history of cirrhosis complication: ascites, variceal bleeding, hepatic encephalopathy, or 3. 2 of the following 4 criteria: * ultrasound (us), computerized tomography (ct) or magnetic resonance imaging (mri) imaging findings of cirrhosis (cirrhotic appearing liver, splenomegaly, varices, ascites) * fibroscan liver stiffness score \>13 kilopascal (kpa) * laboratory testing: aspartate aminotransferase (ast)/platelet ratio index (apri) \>2.0 * ct, mri or esophagogastroduodenoscopy (egd) showing presence of esophageal varices exclusion criteria: * non-english speaking * unable or unwilling to provide consent * pregnancy via self-report * disorientation at the time of enrollment * history of multiple sclerosis * history of cerebral palsy * history of stroke with paralysis

Keywords: nighttime muscle cramps cirrhosis liver disease qualify of life sleep non-pharmaceutical intervention
baroreflex sensitivity in patients undergoing ablation of atrial fibrillation

Conditions: Paroxysmal Atrial Fibrillation

Summary: atrial fibrillation is the most common arrhythmia. the posterior surface of the left atrium is covered by an extensive network belonging to the autonomic nervous system that can be damaged during the ablation. the involvement of the autonomous nervous system in the genesis and maintenance of atrial fibrillation remains poorly understood. baroreflex sensitivity is a non-invasive method assessing autonomous nervous system activity. the rate of atrial fibrillation recurrence after ablation is currently high and a better understanding of the mechanisms associated with recurrence is essential to improve selection of the patients who will benefit the most from this procedure. the aim of this study is to evaluate the association between the baroreflex sensitivity and atrial fibrillation recurrences and to analyze the prognostic contribution of the baroreflex measurement compared to other published criteria.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old, * patients with paroxysmal atrial fibrillation, hospitalized for atrial fibrillation ablation, * assessable baroreflex sensitivity before ablation, * free subject, without guardianship or curatorship or subordination, * patients benefiting from a social security assurance, * informed consent signed by the patient after clear and fair information about the study. exclusion criteria: * age \< 18, * history of atrial fibrillation ablation, * inability to calculate the baroreflex sensitivity * contraindication to the performance of a cardiac ct scan (allergy to iodine, severe renal insufficiency with clearance \<30 ml/mn/m2), * inability to have continuous ecg recording by subcutaneous holter,
comprehensive electronic cancer support system for the treatment of cancer related symptoms

Conditions: Hepatocellular Carcinoma; Primary Liver Cancer; Bile Duct Cancer; Pancreatic Cancer; Gallbladder Cancer; Colorectal Carcinoma; Liver Metastases

Summary: the purpose of this study is to test the efficacy of a collaborative care intervention to manage cancer-related symptoms and improve health related quality of life in patients diagnosed with hepatobiliary carcinoma.

the study is a collaborative care intervention designed to reduce pain, fatigue, and depressive symptoms and improve overall health related quality of life.

Eligibility criteria:
inclusion criteria: * biopsy, radiological, and/or biological evidence of hepatobiliary carcinoma * age 18 years or older * fluency in english. exclusion criteria included: exclusion criteria: * current suicidal or homicidal ideation * current psychosis or thought disorder

Keywords: hepatocellular carcinoma cholangio carcinoma primary liver cancer bile duct cancerpancreatic cancer gallbladder cancer colorectal carcinoma other primary cancers with liver metastases
volar plating or external fixation of dorsally displaced fractures of the distal radius?

Conditions: Radius Fractures

Summary: promising results have been reported after volar locked plating of unstable dorsally displaced fractures of the distal radius. it offers stable fixation and early mobilization. the investigators' aim is to test if volar locked plating results in better patient-perceived, objective functional and radiological outcomes compared to the less invasive external fixation that has been the standard operation for decades.


Eligibility criteria:
inclusion criteria: * an acute unilateral colles' fracture (ao class a and c1) with a dorsal angulation of more than 20 degrees or radial shortening of 4 mm or more, and * patient aged 20-70 years with no previous fracture of either wrist. exclusion criteria: * bilateral fractures, * other current injury to the upper extremities, * dementia, or * severe comminution or too small distal fragment to allow plating.

Keywords: distal radius fractures fractures of the distal radius volar plate external fixation
a study to assess the efficacy and tolerability of diclofenac potassium soft gelatin capsules compared with ibuprofen tablets in patients with moderate to severe postoperative dental pain

Conditions: Post Operative Dental Pain

Summary: the study is designed to assess the efficacy and tolerability of diclofenac potassium soft gelatin capsules compared with ibuprofen tablets in patients with moderate to severe postoperative dental pain.


Eligibility criteria:
key inclusion criteria: * patients requiring surgical removal of 2 ipsilateral third molars, of which the mandibular must be fully or partially impacted. the ipsilateral maxillary third molar may be of any impaction level. * patients having a moderate to severe baseline pain intensity as assessed by a score of 2 (moderate) or 3 (severe) on the 4-point categorical pain intensity vrs, confirmed by a vaspi score of ≥ 50 mm within 5 hours of surgical completion, after local anesthetic dissipation. key exclusion criteria: * patients who require the removal of a single third molar, or 2 ipsilateral third molars where mandibular molar is not fully or partially impacted. * patients with active peptic ulcer disease or a history of significant gastrointestinal disease or any gastrointestinal bleeding. * patients with coagulation or bleeding disorders. * patients with a positive drug or alcohol screen. * patients who have received an anti-inflammatory agent, analgesic, sedative, hypnotic, muscle relaxant, or tranquilizer within 5 elimination half-lives before administration of study drug (other than surgical anesthetic prior to and during dental surgery).

Keywords: diclofenac potassium post-operative dental pain moderate to severe pain
predictive factors in chronic rhinosinusitis with nasal polyps

Conditions: Chronic Rhinosinusitis With Nasal Polyps

Summary: the study will be conducted to identify factors predicting the response of chronic rhinosinusitis with nasal polyps ( crswnp) to oral corticosteroids.

treatment of nasal polyposis is divided into medical or surgical treatment . steroids are widely used as the most effective medicine in nasal polyposis. although oral corticosteroids are one of the frequently used treatments in the management of chronic rhinosinusitis with nasal polyps (crswnp), there is lack of effective means of predicting corticosteroid sensitivity in those patients. it was reported that the overall sensitivity rates of corticosteroid therapy to nasal polyps( np) were only between 53.8% and 80%.. many reports stated that serum and tissue interleukeine 25 (il 25) and serum and tissue eosinophalia are good predictors to the response of crswnp to oral corticosteroids. interleukeine 25(il-25), an important epithelial-derived proinflammatory cytokine, plays various roles in different inflammatory and allergic diseases, such as asthma and atopic dermatitis . hong et al demonstrated that the levels of il-25 in np tissues and in serum, as well as the np endoscopic scores, were significantly elevated in the corticosteroid-sensitive patients compared with the non-sensitive ones. in general, eosinophilic nps are pharmacologically glucocorticoid responsive, but non-eosinophilic or neutrophilic crswnp is frequently resistant to steroid treatment.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic rhinosinusitis with nasal polyps exclusion criteria: * 1-patients who had taken any steroid , antihistamine or other immune-modulating medications within the past 4 weeks 2- previous nasal and sinus surgery. 3-allergic fungal rhinosinusitis. 4-unilateral rhinosinusitis. 5- antrochoanal polyps or cystic fibrosis.
accuracy of amniotic fluid lamellar body counting for evaluating of fetal lung maturity

Conditions: Retained Fetal Lung Fluid

Summary: the purpose of this study is to determine the accuracy of amniotic fluid lamellar body counting for evaluating of fetal lung maturity.

respiratory distress syndrome (rds) is one of important cause of mortality in neonates. this study was designed to evaluate the amniotic fluid lamellar body counting for predicting fetal lung maturity.

Eligibility criteria:
inclusion criteria: * women, with 28-37 weeks of gestational age, who had been decided to terminate their pregnancy, were enrolled in the study exclusion criteria: * chorioamnionitis * intra uterine fetal death (iufd) * blood in amniotic fluid * rupture of placenta and patient dissatisfaction were the exclusion criteria.

Keywords: respiratory distress syndrome lung maturity lamellar body
evaluating clonogenic epithelial cell populations in patients with bronchiolitis obliterans syndrome

Conditions: Bronchiolitis Obliterans

Summary: this study investigates a type of cell, called abnormal clonogenic epithelial cells, in patients with bronchiolitis obliterans syndrome who have had an donor stem cell transplant or a lung transplant. learning more about clonogenic cells in these patients may help doctors to detect signs of bronchiolitis obliterans syndrome earlier in future patients.

primary objective: i. to characterize epithelial cell phenotypes in allogeneic hematopoietic cell transplant (allo-hct) recipients at md anderson cancer center (mdacc) and in lung transplant recipients at houston methodist who have bronchiolitis obliterans syndrome (bos). outline: patients undergo collection of blood samples and 3 brushings of the airway during standard of care (soc) bronchoscopy. after the bronchoscopy, patients undergo 2 nasal brushings (swabs). patients' medical records are also reviewed for data collection. after completion of study, patients are followed for up to 1 year.

Eligibility criteria:
inclusion criteria: * allo-hct recipients undergoing a bronchoscopy at mdacc who consent to undergoing study airway brushings in addition to clinically indicated bronchoscopic procedures (e.g. bronchoalveolar lavage) * 5 patients with advanced bos - forced expiratory volume in one second (fev1) =\< 75% predicted and meeting other national institutes of health (nih) criteria (fev1/forced vital capacity \[fvc\] ratio 0.7, presence of air trapping or graft versus host disease \[gvhd\] of another organ) * 5 patient with early bos - at least 10% decline in fev1 from baseline values, with fev1 \>= 75% predicted, and 1 high-risk feature: * active systemic chronic gvhd with new early airflow obstruction or * respiratory viral infection in last three months with resolution of viral symptoms but new airflow obstruction * 3 patients with no pulmonary impairment (fev1 within 5% of baseline values) * lung allograft recipients undergoing a bronchoscopy at houston methodist who consent to undergoing study airway brushing sin addition to clinically indicated bronchoscopy procedures * 5 patients with bos stage 2 or higher (\>= 35% decline in fev1 from baseline values) * 5 patient with bos stage 0p or 1 (10-35% decline in fev1 from baseline values) * 3 patients undergoing screening bronchoscopy without decline in fev1 * patients with undiagnosed lung cancer and chronic obstructive pulmonary disease diagnosed by pulmonary function testing (fev1/fvc less than the lower limit of normal with \>20 pack-year history of smoking) exclusion criteria: * bronchoscopy performed on emergency basis for life-threatening issues as opposed to routine diagnostic testing * patient unwilling to give consent for study airway brushings
characterizing the cross-sectional approach to ovarian cancer: genetic testing of brca

Conditions: Ovarian Cancer

Summary: the multi-centered, cross-sectional investigations shall be conducted in this study with the objective of identifying the ownership ratio of gbrcam on the newly diagnosed patients with epithelial ovarian cancer, primary peritoneal cancer or fallopian tube cancer in japan.

this multi-centered, cooperative and epidemiological observation study is so designed to investigate the ownership ratio of gbrcam in the newly diagnosed patients with epithelial ovarian cancer, primary peritoneal cancer or fallopian tube cancer because such a ratio has not yet been adequately clarified in japan. the newly diagnosed eligible patients with epithelial ovarian cancer, primary peritoneal cancer or fallopian tube cancer shall be asked to participate in this study in order of diagnosis. after obtaining their consents by the written informed consent following appropriate explanation, investigations about the demographic information including the cancer family history shall be performed. subsequently, blood is collected for investigation about gbrcam. in addition, histological classification shall be conducted based on the resected tumor tissues.

Eligibility criteria:
inclusion criteria: for registration to this study, all of the following criteria should be satisfied: 1. the subject can attach the signature to the informed consent form (icf), besides having his/her intention to put the signature. 2. female japanese at more than 20 years of age 3. the newly diagnosed patients whose epithelial ovarian cancer, primary peritoneal cancer or fallopian tube cancer is histologically confirmed as figo from the subject to obtain their utmost understandings. limited to histopathological diagnosis based on resected tumor specimens (except the cytodiagnosis by ascites paracentesis). 4. the histopathological specimens can be submitted to the central pathological judgment. 5. within 60 days after diagnosis of epithelial ovarian cancer, primary peritoneal cancer or fallopian tube cancer, the patient's written consent has been obtained. exclusion criteria: * the subjects who coincide any of the following exclusion criteria are designated to be ineligible: 1. in case of the subjects who are diagnosed to have acute or chronic physical or severe mental diseases except cancer, and about whom the attending responsible physician makes judgement to say that participation of these subjects would possibly increase the risks or would probably disturb the interpretation of the study results. 2. in case of the subjects whose registration for the study is judged by the attending responsible physician as inappropriate.

Keywords: ovarian cancer, gbrcam
retrospective study of mri in pediatric patients

Conditions: Central Nervous System Disease; Central Nervous System Neoplasms

Summary: collection of already existing data and images for patients \< 2 years of age having multihance administration for a mri of the brain or spine. mr images will be reviewed during a prospectively designed blinded reading of the images.


Eligibility criteria:
inclusion criteria: * male or female less than 2 years of age at the time of the mri with multihance injection at a dose of 0.1 mmol/kg (± 25% in volume administered) * has available demographic and safety data * has documented known or highly suspected enhancing disease of the cns (brain/spine) and previously underwent a cranial or spinal mr examination requiring an injection of multihance contrast agent * has both pre and post dose t1 se/fse and/or gre and t2 se/fse, and flair mr images (when available) for submission to sponsor or designee to be evaluated in a fully blinded read * has a documented dose of multihance administered for their mri exam and/or volume (ml) and weight of the patient available to be used to calculate the dose of multihance that was administered exclusion criteria: * any patient who does not fulfill all of the inclusion criteria
usefulness of capillary refill time and skin mottling score to predict intensive care unit admission

Conditions: Shock, Septic; Shock, Hemorrhagic

Summary: in the emergency department (ed), the severity assessment of shock is a fundamental step prior to the admission in intensive care unit (icu). as biomarkers are time consuming to evaluate severity of the micro and macro-circulation alteration, capillary refill time and skin mottling score are 2 simples, available clinical criteria validated to predict mortality in the icu. the aim of this study is to provide clinical evidence that capillary refill time and skin mottling score assessed in the ed also predict icu admission of patients with septic or haemorrhagic shock.

this trial is an observational, non-randomized controlled study. a total of 1500 patients admitted to the ed for a septic or hemorrhagic shock will be followed. the primary outcome is the admission to the icu. the study will not impact the treatments provided to each patient. capillary refill time and skin mottling score will not be taken into account to decide patient's treatments and/or icu admission. patients will be followed during their hospital stay in order to precise their destination after ed (home, icu, ward) and 28- and 90-days mortality after hospital admission.

Eligibility criteria:
inclusion criteria: 1. age \> 18 years 2. skin mottling score\> 2 and/or capillary refill time \> 3secondes associated with at least one of the followings measured at the ed admission by the nurse in charge of the patient: 1. systolic blood pressure \< 90mmhg or blood pressure decrease of 30% at least for patients with high blood pressure history 2. heart rate \> 120 beats per minute 3. respiratory rate \> 22 movements per minute 4. glasgow coma scale \< 13. exclusion criteria: 1. age \< 18 years 2. pregnancy 3. serious co morbid conditions with a not to be reanimated status known at the ed admission 4. patients with guardianship or curator

Keywords: shock sepsis haemoragy intensive care unit prediction
optical frequency domain imaging versus intravascular ultrasound in percutaneous coronary intervention - opinion imaging

Conditions: Coronary Artery Disease

Summary: this study is the sub-study of opinion trial. (umin000010580) the aim of this study is to evaluate how optical frequency domain imaging (ofdi) or intravascular ultrasound (ivus) imaging technology influence to the percutaneous coronary intervention (pci) strategy.

optical frequency domain imaging (ofdi) is a novel, high resolution intravascular imaging modality. intravascular ultrasound (ivus) is a widely used conventional imaging modality for achieving optimal stent deployment. this study is the sub-study of opinion trial. (umin000010580) the aim of this study is to evaluate how ofdi or ivus imaging technology influence to the percutaneous coronary intervention (pci) strategy. we will enroll the first 100 patients who have enrolled in the main-study of opinion trial.(umin000010580). we will assess lesions by the other device in addition to the assigned device in the main study at the time of post-pci. we will then assess lesions by ofdi at a 8-month follo-up.

Eligibility criteria:
inclusion criteria: * patients participating in the opinion trial * patients who has provided written informed consent exclusion criteria: * ineligible patients according to the investigator's judgment * inability or unwillingness to perform required follow up procedures

Keywords: coronary artery disease percutaneous coronary intervention optical frequency domain imaging intravascular ultrasound