Kornimate/medical-research-clean huggingface dataset:
in patients with scad undergoing complex pci, the response study"

Conditions: Coronary Disease

Summary: evaluation of efficacy/safety in cangrelor use in patients with scad undergoing complex pci. prospective, observational, multicenter registry.

scad patients routinely in the italian centers undergo complex pcis with pre-treatment with p2y12 inhibitors or with p2y12 inhibitors administration after procedure. this implies that participants receive interventions as part of routine medical care, and that researchers actually observe the effect of the intervention.

Eligibility criteria:
inclusion criteria: * patient must be at least 65 years of age at the time of signing the informed consent form * patient presenting with scad undergoing complex pci and: * type 2 diabetes mellitus; * ckd (grade specified in crf); * complex scad: lmd, 3vd, bifurcation lesions, rotablator, cto, multiple stents, total length of the stents must be greater than 60 mm. * patient is to be treated for de novo lesions located in previously untreated vessels. * patient must agree to undergo all required follow-up visits and data collection. exclusion criteria: * history of cabg; * in stent restenosis; * patient with intolerance or contra-indications to treatment with aspirin, clopidogrel, prasugrel, ticagrelor, cangrelor, heparin, contrast media; * patient on chronic treatment with oral anticoagulants; * patient with neoplastic or rheumatic diseases; * use of dipyridamole, cilostazol, or anticoagulant therapy during the study period; * bleeding disorder * history of an ischemic stroke or intracranial bleeding * intracranial vascular abnormality; * gastrointestinal bleeding within the previous 6 months or major surgery within the previous 30 days. * women who are pregnant/breastfeeding or who have the potential to become pregnant during the study; * patient with bleeding diathesis in whom antiplatelet drug is contraindicated; * concomitant indication to open heart surgery * inability to provide written informed consent * enrolment in another study within 1 month
dry needling versus ozone in myofascial pain syndrome

Conditions: Dry Needling; Ozone; Trapezius; Trigger Point Pain, Myofascial; Myofascial Pain Syndrome

Summary: the aim of this study is to compare the effects of dry needling treatment (dn) and ozone treatment on pain and functionality in individuals with myofascial pain syndrome affecting the upper trapezius (ut) region.

in this prospective randomized study to be conducted in üsküdar state hospital, patients diagnosed with myofascial pain syndrome in the upper part of the trapezius muscle will be divided into 3 groups. 1st group patients will be given stretching exercises for the upper part of the trapezius muscle. the exercise program will last 15 days. in addition to exercise therapy, the 2nd group will receive dry needling treatment using acupuncture needles of 0.25 x 25mm in size by a physical medicine and rehabilitation specialist with 5 years of experience in the field. active trigger points will be treated. trigger points will be diagnosed according to the criteria determined by simons and travell. dry needling treatment will be applied in 3 sessions, one week apart. in the 3rd group, in addition to exercise therapy, 10 gamma ozone will be applied in a total of 3 sessions, one week apart to the upper part of the trapezius muscle by a physical therapist with 10 years of experience in the field. patients will be evaluated at the beginning of the treatment, after 1 week, at the 3rd week, and after 1 month.

Eligibility criteria:
inclusion criteria: adults (18-65 years) with diagnosed myofascial pain syndrome affecting the upper trapezius area willing and able to provide informed consent able to comprehend and complete study-related assessments diagnosed with myofascial pain syndrome affecting the upper trapezius area, based on clinical assessment and simons and travell criteria no prior exposure to dry needling or ozone therapy for myofascial pain syndrome medically stable and cleared by a physician for study participation no active musculoskeletal injuries or conditions in the upper trapezius area no participation in similar interventions within the last 6 months exclusion criteria: individuals with known contraindications to dry needling or ozone therapy severe cardiovascular conditions or uncontrolled hypertension active infections or skin conditions at treatment sites known bleeding disorders or anticoagulant use diagnosed with any other chronic pain syndrome not related to myofascial pain syndrome any ongoing litigation or compensation claims related to pain conditions recent trauma or surgery in the upper trapezius area previous adverse reactions to dry needling or ozone therapy participation in other investigational studies within the last 3 months history of psychological conditions that might interfere with assessment pregnant or breastfeeding history of malignancy or immunocompromised status neurological disorders affecting upper trapezius function severe cognitive impairments that hinder assessment inability to commit to the study duration or follow-up assessments any change in medication regimen that might impact pain or functionality during the study period
impact of starting dose of vasopressor on hemodynamic response in shock

Conditions: Shock

Summary: this study is designed to assess the effect of initial vasopressor dose on clinical outcomes. to date, there are no clinical guidelines or recommendations regarding the dose of vasopressor medication that should be initiated before titrating to a mean arterial pressure (map) in patients with circulatory shock. high heterogeneity and clinical equipoise regarding this variable exist in routine clinical practice. however, there is strong evidence that delays in achieving map goals lead to worse clinical outcomes. the study will randomize patients with circulatory shock to a low (5mcg/min of norepinephrine) or high (15mcg/min of norepinephrine) initial starting dose followed by the usual protocolized titration to map goal. the time to reach the goal map, organ dysfunction, hospital length of stay, and mortality will be measured for each group.


Eligibility criteria:
inclusion criteria: * patients at least 18 years old * patients who are diagnosed with shock (map \< 65 mmhg) require the initiation of vasopressors * care provided in the ed or admission to the medical intensive care unit (micu) * norepinephrine chosen as first-line vasopressor by the treating clinician exclusion criteria: * patients who are receiving vasopressors or inotropes prior to ui health hospital presentation/admission * baseline map \>/= 65 mmhg * pregnant patients (checked as standard of care on admission) * prisoners. * immediate post-cardiac arrest patients
senior health clinic study

Conditions: Cardiovascular Diseases; Dementia; Frailty

Summary: turku senior health clinic study the turku senior health clinic study was targeted to 75-year-old citizens with an underlying idea that at that age it would be almost the last moment to nudge people towards healthy lifestyle and taking care of their health and functional ability to maintain independent living. the short-term aims of the turku senior health clinic study are to survey health and functional statuses and prevalence of specified risk factors for cvds, dementia, frailty, and functional decline of 75-year-old independently home-dwelling citizens of the city of turku. the aims also include assessment the frequency of follow-up treatments needed, and recommendations given for lifestyle changes and evidence-based drug treatment, as well as fulfillment of these recommendations. also, participants feedback on the turku senior health clinic will be assessed. in addition, based on the results, recommendation for the content and implementation of preventive health clinic targeted to older people will be provided. the long-term aim of the research project is to assess the effects of the turku senior health clinic on the need of institutional care and home care as well as the cost-effectiveness of the clinic during the 10-year follow-up. for this purpose, participants of the senior health clinic study will be compared to that of non-participants and earlier cohorts of 75-year-olds in terms of the use of home care and institutional care.


Eligibility criteria:
inclusion criteria: * citizens of turku * home-dwelling exclusion criteria: * use of munical home care

Keywords: health clinic prevention home-dwelling older people functional ability
skeletal and dental maturational stages in a sample of egyptian subjects with cleft lip and palate deformity

Conditions: Cleft Lip and Palate

Summary: the aim of this research is to evaluate the skeletal and dental maturation of cleft lip and palate patients in a sample of egyptian population using the cvm as indicator for the skeletal maturation and the demirjian method as indicator for the dental one when compared to a group of egyptian non-clp subjects of the same age.

chronological age (ca) is not considered an accurate method for assessing the stage of physical or growth development of an individual in childhood or adolescence. for that reason, skeletal and dental maturation can be used in order to examine the rate of physical maturation of the population. cervical vertebral maturation (cvm) method uses lateral cephalometric radiography to evaluate skeletal maturity. it is considered the preferable method due to its advantage of avoiding unnecessary extra radiation. the cvm method developed by baccetti et al. (2005) depends on the morphology of the three cervical vertebrae (c2, c3, and c4), which divided skeletal growth into six stages of based on the morphology of the previously mentioned cervical vertebrae. the demirjian method is considered as one of the most worldwide used method for assessment of the dental maturation due to its reliability. it depends on panoramic x-rays through which the dental developmental stage of 7 lower left teeth appears, and according to the gender of the patient the sum of values of the teeth will be transform to age through the standard tables of carmen m. nolla; 1960.

Eligibility criteria:
inclusion criteria: (1) subjects with non-syndromic clp aged 6-18 years. (2) subjects with no clp deformity, aged 6-18 years. (4) patients having complete records comprising dental/medical history and a lateral cephalometric and panoramic radiograph. (5) no congenitally missing teeth in the mandible. (6) no previous history of trauma to the face, neck. exclusion criteria: * radiographs of poor quality. * any growth or hereditary or systematic diseases or syndromes * any trauma or fracture of the jaw that might have affected the normal growth of permanent dentition.

Keywords: skeletal & dental maturational stages
dual triggering in patients with a high immature oocyte rate

Conditions: INFERTILITY

Summary: in in vitro fertilization (ivf) cycles, even after adequate triggering, some patients present a high rate of immature oocytes retrieved after controlled ovarian stimulation. in vitro oocyte maturation is still an experimental technique, with poorer results than conventional ivf. for that reason improve in in vivo maturation could have a better impact on reproductive outcome.

investigators performed an observational study analyzing the difference in the percentage of mature oocytes retrieved in patients with more than 50% immature oocytes in a previous ivf cycle triggered with human chorionic gonadotropin (rhcg) compared to the rate of mature oocytes retrieved in subsequent cycles, triggered with both gonadotropin-releasing hormone agonist (gnrha) and (hcg). the main outcome measure was the number and percentage of mature oocytes retrieved.

Eligibility criteria:
inclusion criteria: * bmi of 18-30 kg/m2 * male factor required for icsi exclusion criteria: -

Keywords: ivf dual trigger gnrh agonist hcg mature oocytes
risk factors in the initial presentation of specific cardiovascular disease syndromes

Conditions: Heart Diseases; Cardiovascular Diseases; Acute Myocardial Infarction; Unstable Angina; Chronic Stable Angina; Ischemic Stroke; Cerebrovascular Accident; Subarachnoid Hemorrhage; Transient Ischemic Attack; Abdominal Aortic Aneurysm; Peripheral Arterial Disease; Sudden Coronary Death; Ventricular Arrhythmia; Sudden Death; Cardiac Arrest; Heart Failure

Summary: cardiovascular disease (cvd) is an important public health problem that affects millions of people worldwide. associations between risk factors, such as smoking, dyslipidaemia or hypertension, and prevalent cvd are well documented. however, few studies have investigated associations with onset of disease. the initial manifestation of cvd, for example an episode of unstable angina, is important because it influences the prognosis, the quality of life and the management of disease. furthermore, the extent to which social deprivation, alcohol consumption or atrial fibrillation affects presentation of cvd is poorly understood and deserves further consideration. most previous studies have considered cvd as a single entity. however, differences in aetiology between coronary phenotypes suggest that risk factors may not be shared across specific coronary phenotypes and their relative importance is likely to differ for each phenotype. gaining knowledge of these differences could provide insights into the pathophysiology of specific forms of cvd and could eventually lead to modification of recommendations for patient management and disease prevention. we propose to use the linkage of the national registry of coronary events to general practice records in the clinical practice research database (cprd), to investigate whether demographic, behavioral, and clinico-metabolic risk factors differentially influence the onset of specific types of cvd.


Eligibility criteria:
inclusion criteria: * aged ≥30yrs old * registered in cprd practices in england consenting to data linkage * ≥1 year of up-to-standard pre-study follow-up exclusion criteria: * history of any of the cvd endpoints considered before study follow-up initiation.

Keywords: heart diseases cardiovascular diseases coronary heart disease not otherwise specified cerebrovascular disorders brain diseases central nervous system diseases nervous system diseases atherosclerosis arteriosclerosis pathologic processes acute myocardial infarction myocardial infarction myocardial ischemia infarction necrosis unstable angina chronic stable angina stable angina angina pectoris chest pain pain signs and symptoms ischemia ischemic stroke hemorrhagic stroke stroke subarachnoid hemorrhage transient ischemic attack abdominal aortic aneurysm aneurysm aortic aneurysm aortic aneurysm, abdominal aortic diseases peripheral arterial diseases peripheral vascular diseases vascular diseases peripheral occlusive diseases sudden coronary death ventricular arrhythmia sudden cardiac death cardiac arrest heart failure
improvement of lower digestive endoscopy without anesthesia : evaluation of the virtual reality mask

Conditions: Digestive System Disease

Summary: 90% of colonoscopies are performed with general anesthesia (ga). ga carries risks and requires a prior anesthesia consultation, a dedicated team and technical platform on the day of the examination. these constraints increase the time it takes to organize examinations. this was particularly highlighted during the recent health crisis. the success of colonoscopy without ga varies depending on the patient's experience of the examination. any measure allowing better tolerance of the exam is therefore likely to increase its success rate and avoid rescheduling the exam under ga. a 2017 meta-analysis showed that the use of virtual reality (vr) reduced pain and anxiety during care for burn victims, in trauma and oncology. in upper digestive endoscopy, retrospective studies have shown good tolerability of the examinations and a reduction in pain compared to patients with only local anesthesia. thus, if the vr mask improves the success rate of total colonoscopy by improving tolerance and acceptability, more examinations without ga could be considered. it could also have an economic impact.


Eligibility criteria:
inclusion criteria: patient over 18 years old with an indication for total colonoscopy and accepting without general anesthesia exclusion criteria: * hearing problems or low vision * psychiatric or cognitive disorders hindering communication * history of epilepsy * claustrophobia which can lead to a rejection of the virtual reality mask * history of cybercynetosis during previous use of vr * chronic abdominal pain with baseline visual analogue scale (vas) \> 5 * emergency examination * patient participating in another interventional research on digestive endoscopy * patient not speaking french * patient under guardianship

Keywords: lower digestive endoscopy whatever the indication digestive endoscopy colonoscopy virtual reality
thromboelastography guided blood product transfusion for upper gastrointestinal bleeding in cirrhosis

Conditions: Cirrhosis, Liver; Coagulopathy; GastroIntestinal Bleeding

Summary: the goal of this clinical trial is to compare resuscitation strategies in patients with cirrhosis and gastrointestinal bleeding. the main question it aims to answer is whether thromboelastography guided resuscitation decreased the amount of fresh frozen plasma patients receive. patients will receive blood products guided by thromboelastography in the intervention group. researchers will compare the patients who undergo thromboelastography guided resuscitation to those who receive usual care to see which strategy leads to the use of less blood products, specifically less fresh frozen plasma.


Eligibility criteria:
inclusion criteria: * patient aged 18 years or older * octreotide order placed for the indication of upper gastrointestinal bleeding in cirrhosis exclusion criteria: * none
terlipressin in septic shock: effects on microcirculation

Conditions: Septic Shock; Sepsis

Summary: the present study was conducted as a prospective, randomized study to investigate the effects of vasopressin receptor agonists terlipressin and vasopressin on systemic hemodynamics and microcirculation in patients with catecholamine-dependent septic shock.

60 septic shock patients requiring norepinephrine to maintain mean arterial pressure between 65 and 75 mmhg despite adequate volume resuscitation will be enrolled in the study. after an initial hemodynamic resuscitation aimed at achieve a mean arterial pressure between 65 and 75 mmhg and normovolemia, patients will be randomly allocated to be treated with either a) intravenous administration of terlipressin 1 µg∙kg-1∙h-1 for 6 hrs, b) intravenous administration of arginine vasopressin 0.04 ui∙min-1 for 6 hrs, c) intravenous administration of terlipressin bolus dose of 0.5 mg (each n = 20). in all groups open label norepinephrine will be additionally administered to maintain a mean arterial pressure (map) between 65 and 75 mmhg, if necessary. data from right heart catheterization and sublingual microvascular network will be obtained just before randomization (baseline) and then after 6 hours in the vasopressin, terlipressin infusion and terlipressin bolus groups. the sublingual microvascular network will be studied using the sidestream dark field (sdf)imaging. the device will be applied on the lateral side of the tongue, in an area approximately 2-4 cm from the tip of the tongue. sequences of 10 secs from eight adjacent areas will be recorded on disk using a personal computer. these sequences will be later analyzed by an investigator blinded to the patient's diagnosis and therapy.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of septic shock * vasopressor support to maintain mean arterial pressure (map) between 65 and 75 mmhg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 13-18 mmhg and central venous pressure = 8-12 mmhg) exclusion criteria: * pregnancy * age \< 18 years * present or suspected acute mesenteric ischemia * vasospastic diathesis (e.g. raynaud's syndrome or related diseases)

Keywords: terlipressin vasopressin sepsis septic shock norepinephrine
incisional hernia repair with mesh at waitemata district health board - a 15 year retrospective cohort study'

Conditions: Incisional Hernia

Summary: a retrospective review of all incisional hernia repairs at north shore hospital (nsh), auckland, nz was performed between january 2004 and july 2019. patients who had an open or laparoscopic incisional hernia repair with mesh were included in this study. patients were retrospectively followed up from the date of their operation until the end of the study period.


Eligibility criteria:
inclusion criteria: * primary surgical procedure was incisional hernia repair with mesh exclusion criteria: * suture repair * other hernia repair (not incisional) * operation notes unavailable
evaluation of white sweet potato tube feeding formula on type 2 diabetic residents in long-term care institutions

Conditions: Type 2 Diabetes

Summary: in order to response the increasing of aging population cause losing ability that need long-care needs, the project entitled "10-year long-term care program" from executive yuan in 2007 is carried out to assist economically disadvantaged and disabled elderly to acquire daily nutrition. therefore, the long-term care resident's nutritional status got more attention than before. out of control in blood glucose will not only increase bed sores and urinary tract infection in tube feeding residents but also rise medical expenditures. the nutritional status of long-term care institutions, anyang homes and nursing home are generally bad in nutrition management due to high cost of nutritional supplements from foreign imports that cause the burden of families. in this study, we will recruit diabetic subjects that divide into white sweet potato group (experimental group) and commercial formula group (control group) by using randomized, parallel and open clinical study through tube feeding in sixty days.

all subjects will be evaluated the blood sugar and clinical nutrition assessment such as postural measurement, urine test and blood biomarker examination.

Eligibility criteria:
inclusion criteria: * long-term stability nasogastric or gastrostomy-fed person. * the physician diagnosed as diabetic and regular use of hypoglycemic drugs. exclusion criteria: * psychosis or depression. * hba1c\> 8.5%. * high taking nutritional supplements or steroids drugs. * have undergone abdominal surgery caused by intestinal sticky. * suffering from cancer, ulcers, respiratory infections and other diseases. * currently receiving central venous nutrition therapy or intravenous nutrition therapy. * liver dysfunction (alt ≧ 100 u / l), renal insufficiency (creatinine ≧ 3mg / dl), heart failure (nyfc ii above), moderate anemia (hemoglobin \<9 g / dl).