Kornimate/medical-research-clean huggingface dataset:
outcomes after dorsal wrist ganglia excision with or without pin

Conditions: Wrist Ganglion; Ganglion Cysts; Hand Ganglion; Denervation Atrophy

Summary: the purpose of this study is to determine if a statistical significance exists between outcomes of patients treated for dorsal wrist ganglion cyst with excision alone versus excision and the addition of a partial wrist denervation by resecting the common terminal sensory branch of the pin (posterior interosseus nerve). our hypothesis is that addition of pin improves outcome after dorsal wrist ganglion excision as indicated by post-operative pain, function, ability to perform activities of daily living, and physical exam findings.

the primary endpoint will be outcomes on subject surveys and questionnaires. data will be collected pre- and post-operatively at 2 weeks, 12 weeks, 6 months, and one year. four questionnaires will be used, including the visual analog pain score (vas), disabilities of the arm, shoulder, and hand (quickdash) questionnaire, as well as the patient-reported outcomes measurement information system (promis) pain interference (pi), and the promis pain behavior (pb) questionnaires. secondary outcomes include physical examination consisting of pre- and post-operative pinch and grip strength testing, and active range of motion including wrist flexion and extension ulnar and radial deviation, and weight bearing extension. these will be performed at 2 weeks, 12 weeks, and 6 months post-operatively.

Eligibility criteria:
inclusion criteria: * greater than or equal to 18 years of age * gender: male/female (non-pregnant) * diagnosis of symptomatic (pain and limited ability to perform activities of daily living) dorsal wrist ganglion cyst * subjects who have chosen surgical management for their ganglion cyst diagnosis * fluent in written and spoken english * subject is able to provide voluntary, written informed consent * subject, in the opinion of the clinical investigator, is able to understand the clinical investigation and is willing to perform all study procedures and follow-up visits * non-prisoners exclusion criteria: * less than 18 years of age * non-elective surgery for this diagnosis * chronic wrist instability of the operative extremity * comorbid neurologic maladies of the operative extremity * prior wrist surgery on either extremity * non-english speaking * prisoners * pregnancy * cognitive impairment

Keywords: ganglion cysts dorsal wrist ganglia neurectomy denervation posterior interosseous nerve
step rate in recreational runners

Conditions: Gait Disorder, Sensorimotor

Summary: this will be a pilot study to determine if a 6 week home training program can increase preferred step rate (cadence) in recreational runners. increase in step rate has been correlated with decreased stress at lower limb joints in runners. this has the potential of decreasing overuse injuries in this population. research participants will have their preferred cadence evaluated at the beginning of the study. the athletes will be randomly assigned to two groups. one group will continue to train without intervention and the other group will train at a cadence of 10% higher than their preferred step rate. at the end of 6 weeks the participants will have their preferred cadence reevaluated using the same method as pre-participation cadence was determined. the investigators hypothesis the preferred running cadence of recreational runners following the intervention will be 5-10% greater than prior to the intervention and the increased cadence will be maintained for 6 months following the intervention.


Eligibility criteria:
inclusion criteria: * healthy male or female runners * 18 years of age or greater * run two or more times per week most weeks of the year for at least 4 years * cadence of 85 strides/min or less as determined at initial evaluation * no musculoskeletal injuries or illnesses that would limit running in the last 6 months * currently running at least 15 miles a week exclusion criteria: * baseline running cadence greater than 85 strides/min * inability to run * cardiovascular disease * greater than 2 cardiovascular risk factors * peripheral vascular disease * neurological disease * musculoskeletal injury or disease that causes pain with running

Keywords: run cadence home exercise
m-tapa block for laparoscopic inguinal hernia repair surgery

Conditions: Hernia, Inguinal

Summary: modified perichondral approach thoracoabdominal nerve (m-tapa) block is a novel block that provides effective analgesia of the anterior and lateral thoracoabdominal walls during laparoscopic surgery, in which local anesthetic is applied only to the lower side of the perichondral surface. m-tapa block is a good alternative for analgesia of the upper dermatome levels and the abdominal lateral wall, and may be an opioid-sparing strategy with satisfactory quality improvement in patients undergoing laparoscopic surgery. m-tapa block provides analgesia at the level of t5-t11 in the abdominal region. sonoanatomy is easy to visualize and the spread of local anesthetic can be easily seen. analgesia occurs in several dermatomes thanks to the cephalocaudal spread of the local anesthetic solution. there are studies in the literature investigating the effectiveness of m-tapa block for post-operative pain management in several abdominal surgeries.

modified perichondral approach thoracoabdominal nerve (m-tapa) block is a novel block that provides effective analgesia of the anterior and lateral thoracoabdominal walls during laparoscopic surgery, in which local anesthetic is applied only to the lower side of the perichondral surface. m-tapa block is a good alternative for analgesia of the upper dermatome levels and the abdominal lateral wall, and may be an opioid-sparing strategy with satisfactory quality improvement in patients undergoing laparoscopic surgery. m-tapa block provides analgesia at the level of t5-t11 in the abdominal region. sonoanatomy is easy to visualize and the spread of local anesthetic can be easily seen. analgesia occurs in several dermatomes thanks to the cephalocaudal spread of the local anesthetic solution. there are studies in the literature investigating the effectiveness of m-tapa block for post-operative pain management in several abdominal surgeries. in this study, we aimed to evaluate the effectiveness of m-tapa block for postoperative analgesia management after laparoscopic inguinal hernia repair surgery. our primary aim is to compare the postoperative pain scores (nrs), and our secondary aim is to compare the postoperative rescue analgesic use and postoperative opioid consumption, and the side effects (allergic reaction, nausea, vomiting) associated with opioid use.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) classification i-ii * scheduled for laparoscopic inguinal hernia repair surgery under general anesthesia exclusion criteria: * bleeding diathesis * receiving anticoagulant treatment * known local anesthetics and opioid allergy * infection of the skin at the site of the needle puncture * pregnancy or lactation * patients who do not accept the procedure

Keywords: laparoscopic inguinal hernia repair postoperative pain management modified perichondral approach thoracoabdominal nerve (m-tapa) block
a pilot study of berberine (soloways ™) in patients with type 2 diabetes mellitus carrying tcf7l2 polymorphisms

Conditions: Diabetes Mellitus

Summary: this pilot, genotype-stratified clinical trial aims to investigate the safety and preliminary efficacy of berberine supplementation in adult patients with type 2 diabetes mellitus (t2dm) who carry a specific high-risk tcf7l2 polymorphism (e.g., rs7903146) in the homozygous state. the study will compare improvements in glycemic control and metabolic markers between two groups: (1) homozygous carriers of the tcf7l2 "unfavorable" variant and (2) non-carriers (wild-type). it is hypothesized that berberine will yield greater reductions in hba1c and fasting plasma glucose among homozygous carriers, potentially due to their distinct tcf7l2-mediated insulin secretion and sensitivity pathways.

type 2 diabetes mellitus is driven by a combination of insulin resistance and impaired insulin secretion. genetic polymorphisms in the transcription factor 7-like 2 (tcf7l2) gene have been strongly associated with an increased risk of t2dm, potentially through altered beta-cell function and incretin signaling. berberine, a natural alkaloid derived from plants such as coptis chinensis, has demonstrated hypoglycemic effects by modulating pathways like ampk, thereby improving insulin sensitivity and glucose metabolism. this pilot trial aims to clarify whether berberine offers a more pronounced metabolic benefit to individuals homozygous for a "high-risk" tcf7l2 polymorphism by targeting their unique pathophysiological mechanisms. results will inform future larger-scale, genotype-focused interventional trials.

Eligibility criteria:
inclusion criteria: * adults (age 30-70 years) with a confirmed diagnosis of type 2 diabetes mellitus. * on stable doses of metformin or other standard oral antihyperglycemic agents for at least 4 weeks prior to enrollment. * willingness to undergo genetic testing for tcf7l2 polymorphisms. for the homozygous variant cohort: confirmed homozygous high-risk tcf7l2 polymorphism (e.g., rs7903146) prior to enrollment. * for the non-variant cohort: confirmed wild-type tcf7l2 genotype. exclusion criteria: * current use of insulin therapy or recent (within 4 weeks) change in diabetic medications. known hypersensitivity or intolerance to berberine or related compounds. * significant renal or hepatic impairment. * pregnancy or breastfeeding. * any other acute or chronic condition that, in the investigator's judgment, could compromise the patient's safety or the study's integrity.

Keywords: diabetes mellitus type 2 diabetes supplements genetics berberine hba1c
egfr molecular classification in vivo

Conditions: Molecular Imaging

Summary: the investigators developed 18f-irs as a targeted molecular imaging agent for noninvasive and repeatable detecting egfr-activating mutational status.

the goal of investigators were to evaluate the use of 18f-irs as a novel pet/ct radiotracer to monitor egfr-activating mutational status and identify egfr-tkis benefit nsclc patients. the investigators want to evaluated the use of 18f-irs in lung cancer imaging in adult nsclc patients with different egfr mutational status of primary and metastatic cancers.

Eligibility criteria:
inclusion criteria: * advanced nsclc * 18 years or older * a life expectancy of at least 12 weeks * presence of a malignant lesion within the chest of at least 0.5 cm diameter as measured by computed tomography (ct) * written informed consent exclusion criteria: * claustrophobia * pregnancy * metal implants in the thorax
transvaginal ultrasound cervical length measurements in twin gestations

Conditions: Pregnancy

Summary: the purpose of this study is to determine if the use of routine transvaginal cervical length ultrasound can be used to prevent preterm deliveries in twin gestations.

this is a randomized controlled trial to determine whether there is a difference in the rate of preterm birth among women with twin pregnancies whose clinicians are aware of transvaginal ultrasound cervical length measurements compared to those managed without this information. the study group had transvaginal cervical length ultrasound monthly from 16-28 weeks and were managed with a standard algorithm for activity restriction and cerclage depending on the cervical length. the control group had digital cervical exams and routine transvaginal cervical length ultrasound was not utilized. the primary outcome was the mean length of gestation. secondary outcomes included percentage of deliveries \< 35 weeks, maternal and neonatal outcomes.

Eligibility criteria:
inclusion criteria: * twin pregnancy * gestational age \< 20 weeks exclusion criteria: * history of incompetent cervix with plans to place a cerclage * history of possible cervical incompetence with preexisting plans to monitor cervical length * prior preterm birth at \< 28 weeks gestational age * plans to leave the area before delivery * known major fetal anomaly * known diagnosis of twin-twin transfusion syndrome * age \< 18 * monoamniotic twins

Keywords: twins twin gestation preterm birth prevention
outcomes database to prospectively assess the changing therapy landscape in renal cell carcinoma

Conditions: Metastatic Renal Cell Carcinoma

Summary: odyssey rcc is a prospective, observational phase iv study is to understand the cancer management and health-related quality of life in patients with mrcc in routine real-world clinical practice in the united states, including both community and academic treatment settings.

this trial is a prospective, observational phase iv study is to understand the cancer management and health-related quality of life in patients with mrcc in routine real-world clinical practice in the united states, including both community and academic treatment settings. primarily, the study will evaluate patient experience through collection of patient reported outcomes (pros). the study will also collect and assess information on the therapies used such as first-line treatment selection, treatment sequence and duration, the drivers of physician selection of particular agents, and discontinuation of therapies. the primary objective is to determine distinct patterns of change in the quality of life and symptom burden in mrcc patients receiving therapy. patients will be identified and undergo consent and baseline assessments, including research blood collection and processing, by the study site team, this baseline visit will be their only clinic visits per protocol. all other visits are standard of care visits and outside the scope of the study. subsequent follow up with be coordinated centrally by dcri. additional clinic data will be obtained via pcornet data pull and medicare claims. patient reported outcomes, quality of life and medications data will be obtained via the dcri call center through follow-up phone interviews.

Eligibility criteria:
inclusion criteria: * age 19 or over at time of informed consent. * diagnosis of metastatic renal cell cancer (mrcc) with less than or equal to (≤) 3 months of first-line systemic therapy or less than or equal to (≤) 3 months of second-line systemic therapy for mrcc. 1. prior surgery and radiation therapy are permitted. 2. prior neoadjuvant and adjuvant therapy for non-metastatic renal cell carcinoma are permitted. 3. patients currently not on therapy and being observed are permitted. * evidence of signed and dated informed consent document indicating that the patient has been informed of all pertinent aspects of the study. * ability to comply with completion of pros exclusion criteria: * patients being treated for metastatic solid tumors other than mrcc are excluded. non-cytotoxic oral agents for adjuvant or maintenance therapy of other cancers are permitted. * patients who are not intending to undergo follow up care at a study site within pcornet

Keywords: odyssey mrcc metastatic renal cell carcinoma rcc pro
role functioning changes nos

Conditions: Schizophrenia; Psychotic Disorders; Bipolar Disorder

Summary: during this study the investigators will 1) collect measures of social cognition and social functioning in adolescents and young adults who are experiencing early symptoms of a major mental disorder; and 2) evaluate the predictive value and utility of a new role functioning assessment measure for individuals experiencing changes in their lives after an index episode of mental illness. this will happen in the context of providing treatment-as-usual to individuals who arrive seeking help with the early phases of mental illness.

the early symptoms of major mental disorders, such as bipolar disorder and schizophrenia, can be non-specific, attenuated, or intermittent. these symptoms nevertheless frequently interfere with an individuals' ability to effectively carry-out multiple aspects of their everyday lives, including social, vocational, and educational functioning. functional changes may in fact occur before individual symptoms reach the threshold for clinical significance. relying solely on the emergence of early symptoms of psychopathology can delay treatment or lead to the improper selection of treatments that are not effective. therefore, measuring changes in real-world functioning that correlate with or predate symptoms may be a useful tool for developing an effective treatment plan. while psychopharmacology and psychotherapy can improve some symptoms of severe mental illness, much less is known about the mechanisms for improving impairments in social cognition. importantly social cognition affects not just social functioning, but many critical aspects of real-world functioning. thus, advancing our understanding of how social cognition and real-world functioning change over time, and their association to changing clinical symptoms, will help improve our understanding of early mental illness, and should inform patient care in new ways. currently, there are only a limited number of tools available for assessing aspects of real-world functioning as they connect to social cognition. therefore, the overarching goal of the present study is to conduct a pilot study to develop a new tool that measures functioning and evaluate the relationship between this new tool and measures of social cognition and symptoms.

Eligibility criteria:
inclusion criteria: 1. age 18 to 26 years 2. individuals seeking treatment for psychiatric symptoms in a clinical care setting 3. able to provide informed consent (age 18-26) 4. subjects must consent to a review of the medical records in order to track changes in clinical symptoms 5. fluent in english exclusion criteria: 1. adults unable to consent 2. individuals who have not reached the age of 18 3. pregnant women 4. prisoners.

Keywords: cognition early mental illness role functioning
kid stride: exploring participation in a family-based intervention

Conditions: Obesity

Summary: the aim of this qualitative study is to explore parental and child perceptions of participating in a family-based behavioral intervention targeting healthy behaviors.

children ages 9-14 have been participating in the kid stride study which is a family-based behavioral intervention for obese children. participants will be divided into 3 groups according to their change in weight: 1) children who lost greater than 5% of body weight; 2) children who lost less than 5% of body weight or gained less than 1% of body weight; 3) children who gained greater than 1% of body weight. we will invite five families from each of groups 1 and 3 to participate in an open-ended interview.

Eligibility criteria:
inclusion criteria: * completed the 15-week primary intervention phase of kid stride

Keywords: pediatrics, overweight, obese, behavioral intervention
stretching of the diaphragm and cervical impulse technique and its possible spirometric changes

Conditions: Respiratory Disease

Summary: this study investigates the effect of two different techniques, stretching of the diaphragm and cervical level impulse technique c3-c4, in the possible spirometric changes, vital capacity (cv), maximum expiratory flow (pef) and maximum expiratory volume (fev). in relation to the secondary variables (age, physical activity, bmi, sex). the subjects of the study were informed and clarified doubts about it and its subsequent reading and signing of informed consent. the subjects were randomly selected to determine which intervention group they would belong to (g1: intervention group of the diaphragm muscle stretch technique, g2: intervention group of the cervical rotation rotation impulse technique c3- c4, g3: combined technique g1 and g2, g4: control group.the evaluation technique is spirometry.the intervention protocol is as follows, first the pre-intervention spirometry is performed, then the corresponding technique (according to intervention group), then the post-intervention spirometry, the intervention technique and at 5 minutes, the intervention technique is performed.

the objectives of the study are the following: 1. to evaluate the changes in the values of the simple spirometry after the application of the study techniques: muscle stretching technique of the diaphragm (g1), rotation impulse technique of the cervical level of c3- c4 (g2) and combined technique of both (g3); 2. determine the influence of these on measurable respiratory parameters by simple spirometry; 3. compare the spirometric values obtained after applying the study techniques (g1, g2, g3) and the control group (g4: simulation of a previous technique); and 4. analyze the different variables measured (age, gender, weight, height, sports practice and body mass index) in the effects of the applied treatment.

Eligibility criteria:
inclusion criteria: * accept participating in the study (signature of informed consent). * be in an age range between 18 and 50 years. * do not present any exclusion criteria. exclusion criteria: * do not meet the inclusion criteria. * have obstructive and / or restrictive respiratory problems. * perfect transient conditions that affect the respiratory tract, such as colds, sinusitis, influenza, respiratory allergies. * to have a history of rib fractures. * congenital deformities. * to have digestive problems. * paying hepatitis and / or hepatobiliary lesions. * suffer heart disease and / or arterial hypertension. * have abdominal problems. * provide surgical scar on the abdomen, thorax and / or neck. * patience cancer * press any type of pain at the time of conducting the study.

Keywords: diaphragm neck frenic nerve
safety, tolerability, pharmacokinetics and efficacy of azd1208 in acute myelogenous leukemia (aml) patients

Conditions: Acute Myeloid Leukemia

Summary: the purpose of this open label study is to evaluate the safety, tolerability, pharmacokinetics, and efficacy of azd1208 in patients with recurrent or refractory acute myelogenous leukemia (aml). this study will have two parts. in part a, patients will receive escalating doses to identify the maximum tolerated dose (mtd). in part b, the efficacy of the maximum tolerated dose will be evaluated in a expanded group of patients.

a phase ia/ib, open-label, multicentre, two-part study to assess the safety, tolerability, pharmacokinetics and efficacy of azd1208 administered daily in adult patients with recurrent or refractory acute myelogenous leukemia (aml).

Eligibility criteria:
inclusion criteria: * males or females at least 18 years of age * patients with relapsed or refractory acute myelogenous leukemia (aml) or aml secondary to myelodysplastic syndromes, myeloproliferative neoplasm, or chronic myelogenous leukemia * eastern oncology cooperative group (ecog) performance status 0-2 and considered likely to complete at least 4 weeks of therapy exclusion criteria: * with the exception of alopecia, any unresolved toxicities from prior therapy greater than ctcae grade 1 at the time of starting study treatment. * as judged by the investigator, any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension, active bleeding diatheses, or active infection including hepatitis b, hepatitis c and hiv. * active heart disease including myocardial infarction within the last 3 months, symptomatic coronary artery disease, clinically significant arrhythmias not controlled by medication or uncontrolled congestive heart failure * prior allogeneic transplant requiring immunosuppressive therapy (patients with prior allogeneic transplants who remain clinically stable for ≥ 2 weeks or more off immunosuppressive therapy, are eligible) * white blood cell count ≥ 100,000/mm3 (100x10\*9/l) * type 1 diabetes or uncontrolled type ii diabetes * hba1c ≥8% or fasting blood glucose \>160 mg/dl (\>8.9 mmol/l) * baseline fasting total cholesterol \>300 mg/dl (\>7.75 mmol/l)

Keywords: leukemia aml azd1208