Kornimate/medical-research-clean huggingface dataset:
virtual reality cognitive training in alcohol use disorder

Conditions: Cognitive Function; Feasibility

Summary: this study aims to test the feasibility of using exercises in virtual reality for cognitive training of patients with alcohol use disorder undergoing residential treatment.

alcohol use disorder has been associated with diverse physical and mental morbidities. among the main consequences of chronic and excessive alcohol use are cognitive and executive deficits. some of these deficits may be reversed, with improvements in specific cognitive and executive domains, with behavioral approaches consisting in cognitive training. the advent of computer-based interventions may leverage these improvements, but rcts on the use of digital interactive-based intervention are still scarce. the aim consists in exploring whether a cognitive training approach using virtual reality exercises based on activities of daily living is feasible for improving cognitive function in patients with alcohol use disorder undergoing residential treatment. the method consists in a two-arm randomized controlled trial with individuals recovering from alcohol use disorder in a therapeutic community that will be assigned to an experimental and a control group. the experimental group consists of virtual reality-based cognitive training whereas the control group of treatment-as-usual. a comprehensive neuropsychological battery of tests will be used consisting in tests for global cognition, executive functions, and specific tests form memory, attention and cognitive flexibility. the ab design will involve a baseline assessment before intervention and post-intervention assessment.

Eligibility criteria:
inclusion criteria: * at least 18 years old * without history of psychiatric or neurological disorders * attending the inpatient program for rehabilitation of alcohol use disorder exclusion criteria: * psychosis episode during the intervention * withdrawal from the inpatient program for rehabilitation of alcohol use disorder
socio-aesthetic intervention on body image and quality of life in women with breast cancer.

Conditions: Breast Cancer

Summary: the aim of this study is to evaluate the impact of a socio-aesthetic intervention on body image and quality of life in post-surgical patients with mastectomy or tumorectomy for breast cancer.two groups of randomized subjects were constituted. patients of the experimental group received 2 or 3 aesthetic care during the first post-surgical week, whereas those of the control group not. body image, quality of life and diverse other personality variables were assessed at three different times: surgical operation day before, exit day before of hospitalization and three months afterwards. our general hypothesis is that subjects who receive aesthetic care report levels significantly higher of corporal satisfaction and of quality of life at the end of the hospitalization and three months later than patients of the control group.


Eligibility criteria:
inclusion criteria: first diagnosis of cancer and first surgical treatment for cancer diagnosis of breast cancer exclusion criteria: psychiatric antecedents inclusion in another psychosocial research

Keywords: aesthetic care, mastectomy, breast cancer, quality of life, body image, psychological adjustment
effect of renal denervation in end staged renal disease with resistant hypertension

Conditions: Hypertension

Summary: a. hypertension is a major cardiovascular risk factor and numerous treatment strategies have been developed to treat hypertension properly and reduce cardiovascular risk. b. however, there is a subgroup of hypertension which are resistant to treatment. 1. resistant hypertension is associated to sympathetic hyperactivity 2. renal sympathetic nerve is known to be associated with systemic sympathetic activity 3. according to research of recent years, catheter based renal sympathetic denervation is a safe and effective treatment modality to treat resistant hypertension c. resistant hypertension is observed in end stage renal disease (esrd) frequently. d. sympathetic hyperactivity is observed in esrd patients e. catheter based renal sympathetic denervation is expected to improve resistant hypertension in esrd patients f. the aim the present study is to evaluate the effects and safety of catheter based renal sympathetic denervation on resistant hypertension in esrd


Eligibility criteria:
inclusion criteria: * patients who are under hemodialysis due to end stage renal disease * patients who have resistant hypertension with office sbp \>160 mmhg) * patients who are or over 18 years old. * patients who submit informed consent exclusion criteria: * known secondary hypertension patients * patients who have renal artery which is not adequate for renal denervation 1. the main renal artery diameter \< 4 mm, or renal artery length \< 20 mm 2. the renal arteries into which stable catheter insertion is difficulty and which have hemodynamically or anatomically significant stenosis 3. the renal arteries who have undergone renal angioplasty * patients who have history of myocardial infarction, unstable angina, syncope cerebrovascular insufficiency or extensive atherosclerotic disease with intravascular thrombosis, or unstable plaque * type 1 diabetes * patients who have scheduled percutaneous coronary intervention (pci) or operation within 6 months * hemodynamically significant valvular heart disease in which blood pressure reduction may cause significant deterioration of patient's health. * primary pulmonary hypertension * patients who have the intracardiac defibrillator(icd) or pacemaker which do not allow delivery of radiofrequency energy. * patients who require continuous oxygen supply or mechanical ventilation for treatment of obstructive sleep apnea * patients who have serious medical condition which can compromise the safety of the patients and the safety and integrity of the study. * patients who have unresolved drug issue, alcoholism * patients who lack ability to understand and follow the instruction the researcher * patient who cannot follow up * patients who are registered in other trial * patients who are pregnant, nursing or planning to be pregnant

Keywords: hypertension
educational video program to promote physical activity and reduce migraine frequency in adults with migraine

Conditions: Migraine Disorders; Exercise; Health Education; Audiovisual Aids; Surveys and Questionnaires

Summary: the goal of this clinical trial is to learn if an educational video program can help reduce migraine frequency and improve migraine-related outcomes in adults with migraine. the main questions it aims to answer are: * does the video-based intervention reduce the number of monthly migraine episodes? * does it reduce the use of acute migraine medication? * does it increase the physical activity levels? researchers will compare participants who watch educational videos about physical activity with participants who receive usual care, to see if the intervention has additional benefits. participants will: * be randomly assigned to one of two groups: intervention or control * the intervention group will watch seven short educational videos over a period of 3 months * all participants will complete questionnaires before and after the intervention period to assess migraine impact, frequency, medication use, and physical activity levels


Eligibility criteria:
inclusion criteria: * adults aged 18 years or older * diagnosis of episodic or chronic migraine confirmed by a neurologist, based on the 3rd edition of the international classification of headache disorders (ichd-3) * willing and able to participate in the study exclusion criteria: * inability to read or understand the study materials * inability or unwillingness to collaborate with study procedures * refusal to participate * diagnosis of other primary headache disorders (except for medication overuse headache) * presence of substance use disorders * presence of chronic medical conditions that limit physical activity (e.g., rheumatic diseases, systemic inflammatory conditions, neoplastic diseases) * presence of severe psychiatric disorders

Keywords: migraine disorders exercise health education audiovisual aids surveys and questionnaires
epidemiological study to evaluate the management of patients with chronic hepatitis c and previous treatment failure

Conditions: Hepatitis C

Summary: the purpose of this study is to describe the management of patients with chronic hepatitis c and previous treatment failure.


Eligibility criteria:
inclusion criteria: * patients of both sexes older than 18 years old. * patients with hepatitis c who had previously failed to the standard therapy. * patients who have given written informed consent to participate in the study. exclusion criteria: * patients with clinical and/or social conditions that might interfere with the development of the study (terminal diseases, cognitive detriment, severe psychiatric disease which prevent from obtaining the information required, prolonged absences during the study). * patients who are participating in other research trials or under treatment with any agent contraindicated according to the summary of product characteristics or other circumstance which requires a patient management different from the investigator's regular clinical practice.

Keywords: hepatitis c viral non-a non-b parenterally-transmitted
the effects of periodontal therapy on glycemic control in diabetic patients

Conditions: Chronic Periodontitis, Generalized

Summary: is the non-surgical periodontal therapy can improve glycemic control in type 2 diabetic patients with chronic periodontitis?

the aim of the present study was to monitor the clinical outcomes and the metabolic response of non-surgical periodontal therapy in patients with chronic periodontitis and uncontrolled type 2 diabetes. regarding clinical and metabolic parameters at baseline, no differences were displayed between two groups. however, at 3-months follow-up period the patients within a test group were demonstrated better clinical outcomes than patients in a control group

Eligibility criteria:
inclusion criteria: diagnosis of diabetes type 2 for more than five years type 2 diabetes with hba1c level from 7% to 9% at the last medical evaluation diagnosis with chronic periodontitis exclusion criteria: pregnancy * alcoholism and smoking * presence of any systemic disorders other than hypertension and diabetes * diabetic major complications
a study of glcnac on tear production in ngly1-cddg

Conditions: NGLY1 Deficiency

Summary: in patients with ngly1-cddg, the disorder can lead to eye damage due to not being able to produce enough tears. this study is being done to see if the dietary supplement, glcnac, improves tear production in patients with ngly1-cddg.

this study is a multicenter randomized, double-blind, placebo-controlled trial of glcnac supplementation for improvement of tear production in ngly1-cddg. clinical history and screening data will be reviewed to determine subject eligibility. if a subject is already on glcnac, a washout period of 1 month will be required prior to consent and randomization. interested subjects who have a molecularly confirmed diagnosis of ngly1-cddg will be consented. baseline data will be collected prior to randomization at treatment initiation. subjects will then be randomized to placebo or glcnac. they will be administered weight-dependent doses of glcnac or an equivalent volume of placebo enterally for 6 weeks, followed by open label weight-dependent doses of glcnac for 6 weeks. a visit for evaluation and collection of lab samples will be conducted at 6 and 12 weeks.

Eligibility criteria:
inclusion criteria: * previously molecularly confirmed ngly1-cddg * between the ages of 1 year old to 60 years old * parent or legal guardian available to provide consent on behalf of minor subjects or adult subjects who are unable to give informed consent due to developmental disabilities. willingness of subject or legal guardian to provide consent. * non-pregnant, non-lactating female subjects of childbearing potential who are heterosexually active must agree to use a highly effective method of contraception for the duration of the study. a highly effective method of birth control is defined as one that results in a low failure rate (i.e., \&lt;1% per year) when used consistently and correctly, such as oral/injectable/inserted/implanted/transdermal contraceptives, condom with diaphragm, condom with spermicide, diaphragm with spermicide, intrauterine hormone- releasing system, or intrauterine device (iud), or sexual abstinence. contraception is not required where at least 6 weeks have passed since sterilization, defined as females having undergone one of the following surgeries: hysterectomy, bilateral tubal ligation or occlusion, bilateral oophorectomy, or bilateral salpingectomy; and males who are vasectomized. contraception is not required where females are postmenopausal (defined as 12 consecutive months of spontaneous amenorrhea and age ≥51 years).. exclusion criteria * hypersensitivity to any of the components of the placebo * history of treatment with glcnac within 28 days of visit 1 * participation in another therapeutic trial - the subject will not be permitted to participate in any other drug trial during the blinded phase and during the 28 days prior to visit 1 * shellfish allergy * planned eye surgery within 3 months of enrollment * • females that are pregnant, nursing or less than 6 months postpartum or attempting to conceive
turkish version of evaluation of the ability to sing easily (ease-tr)

Conditions: Voice Fatigue

Summary: the aim of the study is to translate and culturally adapt the turkish version of the ease (ease-tr) scale and investigate its validity and reliability.

the study consists of two phases. in the first phase of the study, the scale will be translated and culturally adapted into turkish. the second phase involves assessing participants and validating the translated scale. in this phase, participants will complete the ease-tr and the severity part of the vocal tract discomfort scale (vtds) before and after a 1-hour performance. one hundred choir member between the ages of 18 and 65 will be included in the study. both construct and criterion validity procedures will be used.within the scope of construct validity, the "known groups validity" method will be used based on variables such as experience duration, vocal training status, and the presence or absence of current vocal complaints. a comparison of pre- and post-performance ease-tr scores will be conducted. regarding criterion validity, the correlation between ease scores and the severity part of the vtds will be examined. for reliability, cronbach's alpha and test-retest reliability will be calculated. the questionnaire will be administered a second time to 30 participants after 14 days in order to measure test-retest reliability.

Eligibility criteria:
inclusion criteria: * having turkish as mother tongue * singing in choir at least 6 months * performing at least for an hour exclusion criteria: * having previously received voice therapy or undergone voice surgery * having a systematic/or neurological disorder that may affect voice quality

Keywords: singing voice professional voice users
atazanavir for hiv infected individuals: an early access program

Conditions: HIV Infections

Summary: the purpose of this clinical research study is to provide atazanavir to patients infected with human immunodeficiency virus (hiv) whose antiviral medications are no longer working to control hiv activity within the body and who are unable to create a new treatment regimen using other available anti-hiv drugs, because of either side effects or treatment failure previously taken. the safety of this treatment will also be studied.


Eligibility criteria:
key inclusion criteria: * patients eligible for inclusion into the eap are those that are a virologic failure due to resistance, intolerance and/or adherence problems with current anti-hiv medications; * or have multiple toxicities or intolerance to their anti-hiv medication but are not a virologic failure; * or have severe elevated lipids in the blood (e.g., cholesterol, triglycerides) that do not respond to lipid-lowering medication. key exclusion criteria: * restrictions apply regarding the use of atazanavir with specific medications which may have a potential to cause possible side effects when taken together. * patients will also be excluded for any of the following reasons: 1) pregnancy or breast feeding, 2) elevated liver enzymes, 3) significant cardiovascular disease, or 4) other restrictions as indicated in the protocol.

Keywords: treatment experienced
myelodysplastic syndrome (mds) gastrointestinal (gi) tolerability study

Conditions: Myelodysplastic Syndrome; Transfusional Iron Overload

Summary: the objective of the study is to evaluate and compare the frequency and severity of gi adverse events in different dose administration regimens. the patient population consists of low or intermediate (int-1) risk myelodysplastic syndrome (mds) patients with transfusional iron overload. the study patients are randomized to either a morning dose of 20 mg/kg/day deferasirox or an evening dose of the same. patients are then followed up for 6 months for any gi events and are assessed using patient reported outcomes tools e.g. a patient diary.


Eligibility criteria:
inclusion criteria: * written informed consent prior to any screening procedures * male or female patients ≥ 18 years of age * patient must weigh between 45-135 kg * patients with low or intermediate (int-1) risk mds, as determined by ipss score or ra, rars by who criteria. ipss must be confirmed by a bone marrow examination within 6 months prior to study entry and must be hematologically stable deferasirox naïve: sexually active pre-menopausal female patients must use double-barrier contraception, oral contraceptive plus barrier contraceptive, or must have undergone clinically documented total hysterectomy and/or oophorectomy, tubal ligation exclusion criteria: * history or current gi disease * systemic diseases which could prevent study treatments * left ventricular ejection fraction\< 50 % by echo cardiography * serum creatinine \> 1.2 x uln at screening * platelet counts \< 25x 109/l except in cases where guidance is already given in the local deferasirox label * ast or alt \> 2.5 xuln at screening other protocol-defined inclusion/exclusion criteria may apply

Keywords: gastrointestinal adverse events, myelodysplastic syndrome, transfusional iron overload diarrhea, constipation abdominal pain, vomiting
delphi evaluation of psychiatric conditions

Conditions: Major Depressive Disorder; Bi-Polar Disorder; ADHD; Schizophrenia; OCD; Ptsd; Healthy

Summary: delphi acquisition and analysis software, a quantalx neuroscience development, which is designed to measure, analyze, and display brain electrical activity of human electroencephalogram (eeg), to transcranial magnetic stimulation (tms), will be used to evaluate different psychiatric conditions.

psychiatric conditions requiring pharmaceutical treatment include schizophrenia and other psychotic disorders, major depressive disorder, bi-polar disorder, post traumatic stress disorder, obsessive compulsive disorder and anxiety disorders. to date none of the psychiatric conditions mentioned diagnosis' relies on an imaging or other quantitative technique. diagnosis and treatment prescription in the psychiatric clinic still relies on subjective reports and physician assessment of symptoms. trans-cranial magnetic stimulation (tms) is a noninvasive brain stimulation method that allows to study human cortical function in-vivo. using tms for examining human cortical functionality is enhanced by combining tms with simultaneous registration of electroencephalograph (eeg). eeg provides an opportunity to directly measure the cerebral response to tms, measuring the cortical tms evoked potential (tep), is used to assess cerebral reactivity across wide areas of neo-cortex. studies integrating tms with eeg (tms-eeg) have shown that tms produces waves of activity that reverberate throughout the cortex. and that are reproducible and reliable thus providing direct information about cortical excitability and connectivity with excellent time resolution. by evaluating the propagation of evoked activity in different behavioral states and in different tasks, tms-eeg has been used to causally probe the dynamic effective connectivity of human brain networks.

Eligibility criteria:
inclusion criteria: 1. adult male and female patients between the age of 18-80 years old. 2. patients willing to participate with all of the study procedures and sign informed consent form. 3. a clinical diagnosis of psychiatric condition that requires medication or other intervention (such as brain stimulation or psychological treatment).-study groups. 4. without any psychiatric medications or with stable treatment regimen for the last 2 months-study groups.. 4.5. a normal neurological exam- control group. exclusion criteria: 1. prior known epileptic episode. 2. history of any neurodegenerative disease. 3. patients with history of other known brain disorder/pathology. 4. contraindication to mr imaging. -
dexamethasone and dexmedetomidine as an adjuvant to spinal anesthesia for elective caesarean sections

Conditions: Pain, Postoperative

Summary: the main objective of our study is to evaluate analgesic effect of intrathecal dexamethasone and dexmedetomidine in elective caesarean sections


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists classii-iii adult female patient (age :18 -40 years old ) * elective cesarean section under spinal anaesthesia * gestational age \> 37 weeks * bmi less than 30 kg/m2 exclusion criteria: * patient refusal * unable to give consent * age \ 40 * bmi more than 30 kg/m2 * known allergy to the study medication * coagulopathies or on anticoagulant medications * diabetic neuropathy * patients with psychiatric disorders
ast clinical investigation

Conditions: Diabetes

Summary: blood glucose monitoring system are tested in the alternative site to validate the accuracy of the blood glucose.


Eligibility criteria:
inclusion criteria: * people ( disbetes people)with at least 8 hours of limosis exclusion criteria: * after meal(when doing the test) * take hypoglycemic drugs(when doing the test) * with insulin(when doing the test) * after strenuous exercise(when doing the test) * pregnant women * neonates * patients in a hyperglycemic-hyperosmolur state, with or without ketosis. * patients who are dehydrated, hypertensive, hypotensive or in shock.

Keywords: blood glucose