Kornimate/medical-research-clean huggingface dataset:
response to diaphragmatic pacing in subjects with pompe disease

Conditions: Pompe Disease

Summary: the purpose of this study is to determine the effect of diaphragm pacing on respiratory function in subjects with pompe disease by evaluating the duration and pattern of spontaneous respiratory function versus paced ventilation respiratory function in patients with pompe disease who have received the neudx diaphragm pacer (dps).

subjects with pompe disease who are scheduled to receive a neurx diaphragm pacer (dps) will be invited to participate in this study. the following tests will be performed during participation in the study: 1. forced expiratory tests 2. maximal inspiratory pressure (mip) 3. resting breathing pattern 4. phrenic nerve function evaluation with emg 5. severe respiratory insufficiency questionnaire 6. magnetic stimulation 7. diaphragm conditioning consisting of: 1. the external stimulator settings 2. the duration of diaphragm stimulation 3. off-ventilator spontaneous breathing (sb)

Eligibility criteria:
inclusion criteria: * diagnosis of pompe disease as defined by mutational analysis, gaa enzyme activity assay in blood spot, and/or fibroblast culture less than 40% of control value * medically and functionally eligible for neurx dps implantation, as determined by a clinical surgical evaluation. the surgeon will determine eligibility through pulmonary function tests, ability to stimulate your diaphragm, and arterial blood gas levels. eligibility may also be determined by your response to traditional respiratory strengthening exercises without a pacemaker. * history of mechanical ventilation dependence (six or more hours of invasive or non-invasive mechanical ventilation support daily for at least 21 days in duration exclusion criteria: * current participation in another treatment study (other than enzyme replacement therapy) directed at improving diaphragm function * unable to complete pulmonary function testing

Keywords: pompe disease mechanical ventilation diaphragm pacing
forward head posture correction impact on temporomandibular dysfunction

Conditions: Temporomandibular Disorder; Forward Head Posture

Summary: the goal of this clinical trial is to test the effect of nerd neck correction on damaged jaw in people who suffers from jaw problems and nerd neck. the main question it aims to answer: * whether there are different effects of traditional nerd neck correction exercises, device correction method and dental splints on jaw features of pain and function. participants will: * participants will be given the consent to sign first. * participants will be assessed to check jaw pain and function. * participants will be divided randomly into 3 groups. * each group will be given the treatment sessions for 6 weeks. * participants will come back after 6 weeks for one last assessment. researchers will compare traditional, new and dental treatment groups to see if there is improvement in jaw characteristics.

the relationship between the two conditions of forward head posture (fhp) and temporomandibular joint dysfunction (tmd) have been previously stated with comparing the craniocervical angle (cva) of tmd patients to the healthy individuals, still a clear relationship couldn't be drawn due to different study limitations such as the lack of subdivision in the tmd patients based on their diagnostic subcategories in addition to, patients posture might have been altered while the photo was captured. ever since, multiple researchers deliberately investigated the two conditions association and inferred the following: 1. fhp can be a risk factor resulting in tmd where any alteration in the head position produces more tension on the masticatory muscles by changing the mandible position 2. tmd origins from muscular component is more significant than articular component yet the correlation between head posture and tmd is still not clear enough, however, if fhp and myogenic tmd were linked preventive measures can be taken. recently, multiple studies established a relation between the occurrence of fhp in tmd patients which supported the hypothesized relation between them. till present, no study has investigated the fhp denneroll cervical traction orthodontic (dcto) correction impact alone on tmd and this is where the purpose of this study arises from.

Eligibility criteria:
inclusion criteria: * the participant experiencing one or more of tmd signs or symptoms and has been diagnosed with tmd beside having forward head posture with craniocervical (cva) angle \< 50. * the study will be limited to the patients in the dental clinic of the university of sharjah. * participants experiencing mild to moderate myogenic tmd with symptoms of orofacial pain and limited range of jaw opening. exclusion criteria: * previous head, neck or tmj traumas. * history of temporomandibular joint surgery.

Keywords: traction exercise pain temporomandibular dysfunction
trajectory of immunosuppression-caused tremor in kidney transplant recipients

Conditions: Kidney Transplantation; Tremor

Summary: kidney transplant recipients (ktr) have to adhere to a strict immunosuppressive maintenance regime, generally including calcineurin inhibitors (cnis). these cnis, including cyclosporine and tacrolimus, are essential to prevent graft rejection, but are associated with multiple side-effects. one of the most frequently reported side-effects of cnis is the development of tremor: rhythmic, sinusoidal oscillations of the limbs, head or trunk. cni-induced tremor generally occurs soon after initiation of cni maintenance therapy, and occurs in up to half of ktr using cnis. to what extent tremor changes over time and whether this change is objective and/or subjective is currently unknown. in-depth investigation of the course of tremor is therefore warranted, which would add valuable information to previous studies on tremor prevalence. the investigators aim to assess the course of tremor among ktr. the hypothesis is that tremor becomes less severe over time after transplantation, because cni dosage decreases with time after transplantation. however, it may also be hypothesized that cni neurotoxicity may accumulate with consequent worsening of tremor. more information regarding the course of tremor after transplantation is essential to increase understanding of cni-induced tremor, as well as for patient counselling and future research to alleviate the burden of cni-induced tremor.


Eligibility criteria:
inclusion criteria: * patients ≥ 16 years old, who will receive a kidney transplant exclusion criteria: * patients who are unable to comprehend the questionnaires and tests

Keywords: kidney transplant recipient tremor calcineurin inhibitor tacrolimus cyclosporine
chronic pain and hemophilia

Conditions: Chronic Pain; Hemophilia

Summary: hemophilia (a and b) are x-linked hereditary bleeding disorders whose severity depends on the level of coagulation factor (fviii or fix respectively). bleeding is mainly from joints (hemarthrosis) and muscles (hematoma). nowadays, treatment is based on preventive or curative intravenous infusion of coagulation factor concentrates. despite these treatments, there is joint deterioration that can be responsible for hemophilic arthropathy and chronic pain. this pain may be related to excess nociception during acute bleeding, but it may also be neuropathic. there are only a few studies that have looked at pain in hemophilia, but it is accepted that the vast majority of patients (especially those with severe forms) suffer from chronic pain. because patients have become accustomed to this pain and physicians are still not very aware of how to assess it, this pain is not treated effectively. in order to better manage pain in hemophilia, it is therefore necessary to characterize their pain and to know the nociceptive or neuropathic component. the aim of our study is therefore to study the prevalence, the nociceptive or neuropathic profile, the chronic aspect of pain and the main locations of pain in hemophilia. in addition to raising the awareness of physicians in the centers about pain management using specific questionnaires, this survey will help to better define chronic pain in hemophilia of all severities.

this first french assessment of chronic pain in patients with haemophilia will permit to improve and generate new data about chronic pain related to haemophilia, associated-comorbidities, sociodemographic characteristics and analgesic treatments used. these data will be retrieved using several questionnaires in the redcap web plateform (ecrf). the study will include 6 investigator centres and a minimum of 350 patients during 12 months.

Eligibility criteria:
inclusion criteria: * patient with haemophilia of any severity, * carrier female with low levels haemophilia (\< 40%), * ≥ 18 years of age and capable of giving informed consent to participate in research. exclusion criteria: * patient's refusal to participate in the survey, * patient does not understand enough french (written and spoken) to complete the survey, * patient unable to complete the survey for logistical reasons (lack of internet access), * patient under protective measures (guardianship), * patients with known addictive comorbidities and/or cognitive disorders.

Keywords: chronic pain hemophilia
limiting trunk flexion as a self-treatment for low back pain

Conditions: Low Back Pain

Summary: the purpose of the proposed study is to test the effect of an intervention technique that reduces trunk flexion upon rising, on the outcome measures of self-reported back pain and functional impairment in individuals with chronic or recurrent non-specific low back pain (lbp). the intervention is a self-administered and requires no medical intervention or drugs. the technique referred to as the restrained sitting treatment (rst), involves training in minimizing forward bending of the trunk immediately upon rising. the technique builds upon a previous randomized controlled study conducted and published by members of the research team. the underlying premise of rst exploits the natural diurnal pattern as the intervertebral discs (people are tallest when they first wake up). the discs are fully hydrated upon rising, disc internal hydrostatic pressures and external forces acting on surrounding soft tissues are greatest at this time, and these pressures and forces can increase significantly with trunk flexion. the rst technique utilizes a back support used in sitting during the first hour upon rising to minimize trunk flexion during this critical period as the intervertebral discs begins the diurnal cycle of fluid loss. the study will test the null hypothesis that there are no significant difference in outcome (lbp, work or social function/disability) between groups performing rst, the experimental group performing rst upon rising, the control group performing prior to going to bed.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic or recurrent low back pain * six month or longer history of non-specific lbp * minimum 90 days in pain in the last six months * average pain score of past month ≥3 on a 0-10 numerical rating scale exclusion criteria: * red flags (tumor, metabolic diseases, rheumatoid arthritis, osteoporosis, prolonged steroid use, pregnancy, back surgery) * evidence of nerve root compression (pain reproduction with slr\>45º, weakness of major lower extremity muscle group, decreased deep tendon reflexes at knee or ankle, decreased sensation to pinprick) * acute trauma to low back

Keywords: self treatment technique chronic non specific lbp control trunk flexion diurnal
meglimine sodium succinate for correction of metabolic acidosis in critically ill patients

Conditions: Metabolic Acidosis

Summary: an acid-base imbalance, called metabolic acidosis (acid-base disorder lasting from several minutes to several days, caused by a decrease in serum bicarbonate ion (hco3) concentration), is often observed in critically ill patients with various underlying diseases. metabolic acidosis has a negative impact on the cardiovascular, respiratory, digestive, nervous, excretory, hematological, endocrine, musculoskeletal and immune systems and is associated with unfavourable outcomes. reamberin® is a solution of disubstituted sodium salt of succinic acid, which has an alkaline reaction and succinate is capable to integrate into the krebs cycle and restore energy metabolism in the cell. the aim of the present study is to evaluate the efficacy and safety of meglumine sodium succinate at a dose of 500 to 3000 ml in critically ill patients with metabolic acidosis and choose the optimal volume of its solution for the correction of metabolic acidosis in critically ill patients.


Eligibility criteria:
inclusion criteria: 1. signed and dated written informed consent (if unconscious due to a critical condition, the decision is made by a council consisting of 3 physicians) 2. male and female patients aged 18-70 3. critical illness ((shock (including traumatic, hypovolemic), major trauma, acute massive blood loss, acute complicated surgical diseases of the abdominal organs) accompanied by metabolic acidosis, defined as serum bicarbonate \<22mmol/l 4. ph of arterial blood 7.20-7.35, inclusive 5. planned volume of infusion \>= 1500 ml per day 6. interval between admission to the icu and randomization \<24 hours exclusion criteria: 1. pregnant and lactating women 2. known hypersensitivity to any component of the study drug / placebo 3. chronic kidney disease stage c5 (end-stage renal failure) 4. acute hepatic failure (alt \> 15 upper normal limits) or liver cirrhosis 5. traumatic brain injury accompanied by cerebral edema 6. previously diagnosed mental illness 7. any chronic disease in the terminal stage with a life expectancy of \< 3 months 8. hiv infection 9. clinically significant cardiovascular disease (unstable angina pectoris or angina pectoris of functional class iii or higher; chronic heart failure iii - iv class according to nyha; acute myocardial infarction within 6 months before screening) 10. extremely low or extremely high body fat 11. infusion sodium bicarbonate, sodium bicarbonate, trometamol, sterofundin, quintasol, ringer's lactate (hartmann's solution) within 6 hours before screening 12. acute respiratory acidosis 13. poisoning with chemical compounds causing metabolic acidosis 14. alcohol in saliva at screening \>= 0.5 pro mille 15. previously diagnosed chronic obstructive pulmonary disease

Keywords: metabolic acidosis critical illness acid-base disorder
a comparison laparoscopic with open gastric cancer surgery for locally advanced gastric cancer

Conditions: Gastric Cancer

Summary: nowadays, the proportion of patients with locally advanced gastric cancer is estimated up to 90 percent of all gastric cancer cases in russian federation. surgical procedure with d2 lymphadenectomy is the main option for treatment. conventional open approach is still the current standard for advanced gastric cancer. laparoscopic procedures for gastric cancer as minimally invasive surgery has gained popularity for the treatment of early gastric cancer in east asia. several studies indicated that laparoscopic procedures both total and subtotal gastrectomy with d2 lymphadenectomy is a technically feasible and safe procedure by experienced surgeons in high-volume specialized hospitals. however, lack of solid evidence on the oncologic efficacy. starting clinical trials for evaluate safety of oncology laparoscopic subtotal gastrectomy for locally advanced gastric cancer. aim of this trial is show safety, feasibility and oncologic efficacy of laparoscopic radical surgical procedures both total and subtotal gastrectomy for treatment gastric cancer.


Eligibility criteria:
inclusion criteria: * ecog 0-1 * asa i-iii * histologically proven cancer of the stomach ct 2-4a(clinical stage tumor), n0-3, m0 at preoperative evaluation according to the american joint committee on cancer (ajcc) cancer staging manual seventh edition * preoperative examination with no distant metastasis, no significantly enlarged lymph nodes around abdominal main artery, and tumor not a direct violation of the pancreas, spleen and other surrounding organs * the gastric tumors are located in the stomach, are macroscopically resectable by subtotal or total gastrectomy with d2 lymph node dissection. * written informed consent exclusion criteria: * clinically apparent distant metastasis * free cancer cells * bulky lymph node metastasis is detected by abdominal ct * previous treatment with radiation therapy for any tumors. * previous surgery for the present disease * pregnancy * psychiatric disease

Keywords: gastric cancer locally advanced gastric cancer laparoscopic surgery laparoscopic procedure comparison laparoscopic with open procedure multicenter trials
intra-operative chemotherapy with 5-fu for colorectal cancer patients receiving curative resection: efficacy and safety

Conditions: Colorectal Cancer

Summary: the purpose of this study is to investigate efficacy and safety of intra-operative chemotherapy with 5-fu for colorectal cancer patients receiving curative resection. the hypothesis is intra-operative intervention might be the best timing for cancer cells killing by cytotoxic agents, when most of residual cancer cells may get a rapid growth after tumor debulking and may become more chemotherapy-sensitive. a three-step procedure is designed for intra-operative chemotherapy with 5-fu of 1500 mg/m2, including step 1 of intraluminal 5-fu injection with 1000 mg/m2 at beginning of resection, step 2 of 200mg/m2 5-fu injection into portal vein system via mesentery vein after tumor removal and finish of bowel reconstruction, and step 3 of 300mg/m2 5-fu left into the abdominal cavity before incision closure. the controlled arm receive curative resection only. all the other treatments will stick to the guidelines.


Eligibility criteria:
inclusion criteria: * histologically confirmed as adenocarcinoma of colon and rectum * age 18-75 years * eligible for curative surgical resection * performance score: ecog 0-1 * normal blood cells counts: wbc ≥ 4.0×10\*9/l，plt ≥ 100×10\*9/l * normal blood chemistry test: alt/ast ≤ 2.5 uln, tbil ≤ 1.5 uln, bun ≤ 1.5 uln,cr ≤ 1.5 uln * normal ecg * no history of other malignant tumors * no concomitant anti-cancer therapy exclusion criteria: * clinical bowel obstruction * anticipated into another clinical trial within three months * uncontrolled infection, serious internal medical diseases * pregnant or lactating women * mentally abnormal patients * patients known allergic to 5-fu

Keywords: colorectal cancer curative resection intra-operative chemotherapy 5-fluorouracil chemotherapy
peri-operative vitamin d therapy for hepatectomy

Conditions: Vitamin D Deficiency; Hepatocellular Carcinoma; Perioperative Complication

Summary: the goal of this double-blind, randomized controlled trial is to test the effect of short-term and high-dose vitamin d therapy in patients undergoing hepatectomy for hepatocellular carcinoma.

participants will receive short-term high dose of vitamin d during perioperative period. the main questions the study aims to answer are: 1. if vitamin d therapy benefits perioperative care 2. if short-term high dose of vitamin d supplement is safe

Eligibility criteria:
inclusion criteria: * patients older than 20 years * patients will undergo hepatectomy for hepatocellular carcinoma. exclusion criteria: * patients with hypercalcemia, hyperparathyroidism, sarcoidosis, multiple myeloma

Keywords: vitamin d therapy hepatocellular carcinoma perioperative complication
utility of multisensory body-representation in spinal cord injury (sci) with pain

Conditions: Spinal Cord Injuries; Neuropathic Pain

Summary: the purpose of this study is to investigate the effectiveness of bodily illusions combined with transcranial direct current stimulation (tdcs) on neuropathic pain symptoms and sensory functions in participants with spinal cord injury (sci) and neuropathic pain.


Eligibility criteria:
the study will be open to people of any ethnicity, racial background, and gender. inclusion criteria: sci with pain: 1. men or women 2. fluent in english 3. 18-70 years of age who have: (3a) complete and incomplete sci, level of injury (above l1); (3b) persistent neuropathic pain started after the injury for a minimum of three months prior to entering the study that is at least moderate in severity, defined as ≥ 4 on a numeric rating scale (nrs) ranging 0 to 10. exclusion criteria: participants will be excluded if they have: 1. major psychiatric disease/disorder (self-reported); 2. a significant neurological trauma (self-reported) other than sci; 3. a recent (one-year) history of alcohol or drug abuse assessed by the drug abuse screening test (dast-10) 4. history of visual and hearing loss not corrected 5. history of epilepsy or seizures 6. any metal implants in the head, or implanted devices such as cochlea implants or cardiac pacemakers. we will not include any special population like: adults unable to consent individuals who are not yet adults (infants, children, teenagers) pregnant women prisoners
the efficacy and safety of tropisetron in preventing emergence delirium

Conditions: Emergence Delirium; Postoperative Delirium

Summary: the purpose of this study is to determine the efficacy and safety of tropisetron in preventing emergence delirium.

delirium is a common complication during postoperative period, especially in elderly patients. the presence of postoperative delirium is independently associated with poor recovery, increased length of hospital stay, the development of long-term cognitive decline and increased mortality. tropisetron is a 5-ht3a receptor antagonist and is widely used to treat postoperative nausea and vomiting. previous studies found that tropisetron has positive effect on cognitive function. this study aims to access the efficacy and safety of tropisetron in preventing emergence delirium. to explore the results differences amongst different patients, subgroup analysis will be conducted according to: a. age (older than 65 years versus 65 years or younger); b. surgery type (major surgery versus minor surgery); c. preoperative moca scores (\>26 versus 18-26 versus 10-17).

Eligibility criteria:
inclusion criteria: 1. written consent given 2. scheduled to undergo elective non-cardiac surgeries under general anesthesia 3. asa physical score i-iii exclusion criteria: 1. patients with a history of neurological disease, such as alzheimer disease. 2. patients with a history of psychiatric disease 3. patients with a medication history of antipsychotic drugs over the last 30 days prior to enrollment. 4. unable to complete neuropsychological testing including patients with severe visual or hearing impairment. 5. the montreal cognitive assessment (moca) scores below 10 6. patients who have severe intraoperative adverse events, such as cardiac arrest. 7. patients with contraindication of tropisetron.

Keywords: tropisetron emergence delirium postoperative delirium