spinal cord associative plasticity study

Conditions: Cervical Spinal Cord Injury; Tetraplegia/Tetraparesis; Cervical Myelopathy

Summary: spinal cord associative plasticity (scap) is a combined cortical and spinal electrical stimulation technique developed to induce recovery of arm and hand function in spinal cord injury. the proposed study will advance understanding of scap, which is critical to its effective translation to human therapy. the purpose of the study is to: 1. determine whether signaling through the spinal cord to the muscles can be strengthened by electrical stimulation. 2. improve our understanding of the spinal cord and how it produces movement. 3. determine whether spinal surgery to relieve pressure on the spinal cord can improve its function. aim 1 is designed to advance mechanistic understanding of spinal cord associative plasticity (scap). aim 2 will determine whether scap increases spinal cord excitability after the period of repetitive pairing. in rats, scap augments muscle activation for hours after just 5 minutes of paired stimuli. whereas aims 1 and 2 focused on the effects of paired stimulation in the context of uninjured spinal cord, aim 3 assesses whether paired stimulation can be effective across injured cord segments. aim 3 will incorporate the experiments from aim 1 and 2 but in people with sci, either traumatic or pre-operative patients with myelopathy in non-invasive experiments, or targeting myelopathic segments in intraoperative segments.

for people with cervical spinal cord injury (sci), regaining hand function is their highest priority. currently there are no effective treatments for people living with paralysis or profound weakness after sci. the goal of this project is to translate a promising therapy for improving arm and hand function after partial spinal cord injury to humans. the approach promotes repair of residual brain to spinal cord connections using combined motor cortex and spinal cord stimulation. the direct brain to spinal cord connection is critical for skilled hand movement in health, and for the loss of movement after injury. after spinal cord injury, many nerve connections for movement are preserved. these connections can be strengthened by electrical stimulation. the investigator has previously demonstrated that pairing brain and spinal cord stimulation strengthens spinal connections in rats. but it is unknown whether this is also applicable in humans. this study is designed to test this in people undergoing spine surgery for pain or decreased movement as well as non-invasively in people with traumatic spinal cord injury. there are three main goals of this project. first, the investigator will stimulate brain and spinal cord (intra-operatively and non-invasively) to try to study the influence of the timing of pairing brain and spinal cord stimulation. second, the investigator will study how repeating the optimal timing (spinal cord associative plasticity; scap) will influence muscle responses over a longer period of time when relatively uninjured parts of the spinal cord are targeted. finally, the investigator will study how the influence of this protocol changes when injured parts of the cord are targeted. stimulation of brain and spinal cord intra-operatively will be performed with the same devices that maintain safety during the surgery, while non-invasive stimulation will be performed with non-significant risk devices. participants: uninjured volunteers, individuals with chronic (\> 1 year) cervical sci, and individuals with cervical myelopathy or radiculopathy requiring clinically indicated decompressive surgery will be recruited. sci and myelopathy participants will have partially retained motor function in the hand, scoring 1-4 (out of 5) on manual muscle testing of finger extension, finger flexion, or finger abduction in left or right hand. participants will also require detectable f-wave responses of the left or right abductor pollicis brevis (apb) to median nerve stimulation and/or first dorsal interosseous muscle (fdi) to ulnar nerve stimulation.

Eligibility criteria:
non-invasive inclusion criteria: (all participants) * age between 18-80 years. * must have stable prescription medication for 30 days prior to screening * must be able to: abstain from alcohol, smoking and caffeine consumption on the day of each experiment; abstain from recreational drugs for the entirety of the study; commit to study requirements (i.e., 7 visits); provide informed consent. (able-bodied participants) * no known central or peripheral neurological disease or injury. (sci participants - including patients scheduled for intraoperative procedures) * score of 1-4 (out of 5) on manual muscle testing of finger extension, finger flexion, or finger abduction in left or right hand. exclusion criteria: (all participants) * personal or extensive family history of seizures; * ventilator dependence or patent tracheostomy site; * use of medications that significantly lower seizure threshold, such as amphetamines, neuroleptics, dalfampridine, and bupropion; * history of stroke, brain tumor, brain abscess, or multiple sclerosis; * history of moderate or severe head trauma (loss of consciousness for greater than one hour or evidence of brain contusion or hemorrhage or depressed skull fracture on prior imaging); * history of implanted brain/spine/nerve stimulators, aneurysm clips, ferromagnetic metallic implants in the head (except for inside mouth); cochlear implants; cardiac pacemaker/defibrillator; intracardiac lines; currently increased intracranial pressure; or other contraindications to brain or spine stimulation; * significant coronary artery or cardiac conduction disease; recent history of myocardial infarction and heart failure with an ejection fraction of less than 30% or with a new york heart association functional classification of class iii or iv; * recent history (within past 6 months) of recurrent autonomic dysreflexia, defined as a syndrome of sudden rise in systolic pressure greater than 20 mm hg or diastolic pressure greater than 10 mm hg, without rise in heart rate, accompanied by symptoms such as headache, facial flushing, sweating, nasal congestion, and blurry vision (this will be closely monitored during all screening and testing procedures); * history of significant hearing problems; * history of bipolar disorder; * history of suicide attempt; * active psychosis; * recent history (\>1 year) of chemical substance dependency or significant psychosocial disturbance; * heavy alcohol consumption (greater than equivalent of 5oz of liquor) within previous 48 hours; * open skin lesions over the face, neck, shoulders, or arms; * pregnancy; and * unsuitable for study participation as determined by study physician. intra-operative inclusion criteria: * clinical indication for cervical spine surgery. exclusion criteria: (for experiments involving cortical stimulation) * epilepsy; * a history of skull surgery with metal implants; * cochlear implants; * patients with aneurysm stents in neck or brain blood vessels; * evidence of skull shrapnel; (for experiments involving spinal cord stimulation) * stimulation devices in the neck or chest (e.g., vagal nerve stimulation, cardiac patients with pacemakers)

Keywords: spinal cord injury paired brain and spinal cord stimulation convergent stimulation spinal cord associative plasticity transcutaneous spinal cord stimulation intraoperative monitoring upper-limb muscle activation motor cortex cervical spinal cord