Kornimate/medical-research-clean huggingface dataset:
genetic factors in chronic sinusitis

Conditions: Chronic Sinusitis

Summary: the purpose of this study is to learn more about the genetics of chronic sinusitis and identify genes involved in chronic sinusitis.


Eligibility criteria:
inclusion criteria: * age\> 18 years * diagnosis of chronic sinusitis or normal sinuses (with verification by imaging.) you must have a recent ct scan showing either normal sinuses or the presence of sinus disease. exclusion criteria: * genetic or acquired immunodeficiency * ciliary dyskinesia * cystic fibrosis * autoimmune disease * cancer of the sinuses
strategies empowering activities in everyday life (see 1.0) a web-based occupational therapy intervention

Conditions: Stroke

Summary: the purpose of the study is to evaluate the feasibility and potential outcomes of a first version of a web-based intervention in occupational therapy focusing on empowering an active everyday life for people with stroke.

a large amount of people with stroke face extensive changes to live an active life and restrictions in engaging in various activities are common. however, the rehabilitation seldom focusses on the process of change people with stroke need to go through to adapt to their changed capacity and reach an active life on new terms. this implies that rehabilitation needs to be developed to provide activity-based self-management strategies that can facilitate an active life. also, there is a need to improve the access to rehabilitation by making use of digital e- health solutions. based on these needs, the web-based occupational therapy intervention "strategies empowering activities in everyday life" (see 1.0) has been developed. this feasibility trial has a pre-test post-test design without a control group. the trial is embedded in a mix- method approach combining assessment tools, feasibility registration forms, intervention logbooks, qualitative interviews and focus groups. the feasibility of the web-based intervention see as well as of the study design, will be evaluated in terms of acceptability, adherence, values and appropriateness from the perspectives of patients with stroke and the staff. also, the potential outcome of see will be evaluated quantitatively and qualitatively. the results will support the continued development of see and provide for larger-scale research studies. the intervention, that combines a focus on empowering an active everyday life with a web-based format including online meetings, is innovative and is not part of clinical practice today. thereby, the results can be valuable for future research and clinical practice in general. the study protocol and the results will be published in peer-reviewed scientific journals and presented at conferences.

Eligibility criteria:
inclusion criteria: * stroke * age: 18-75 years * three to thirty six months after the onset of the stroke * have moderate disability or good recovery after the stroke * have access to a screen/computer, internet and e-id as well as being able to use them * experience limitations in activities in everyday life * be motivated to participate in the program, including be ready for a process of change * be discharged from rehabilitation at hospital or day care. exclusion criteria: * depression * other conditions or diseases that impact on activities in everyday life * have impairments or other diagnoses to such an extent that may have an impact on the ability to consent participation as well as participate in the data collection and intervention.

Keywords: stroke, self-management, activities of daily life, life-style intervention, web-based rehabilitation, tele-rehabilitation, digital e- health solutions, occupational therapy
first-line bosentan and sildenafil combination therapy for pulmonary arterial hypertension

Conditions: Hypertension, Pulmonary

Summary: the purpose of this study is to evaluate the strategy of initiating double oral combination therapy with bosentan and sildenafil at the time of diagnosis of pulmonary arterial hypertension (pah) in a preliminary way.

current treatment paradigms for pah suggest adopting goals of therapy with relatively objective parameters such as 6 minute walk distance to determine when to add a second oral agent (1). this often entails observing deterioration in the patient on a single agent before instituting the second one. this strategy could be problematic, as patients may never recover the function lost due to progressive pah (2). in addition, given the malignant nature of the clinical course of pah in many cases and the nature of the underlying proliferative vasculopathy, some have argued that altering this paradigm to resemble that used in cancer chemotherapy may be more appropriate (3). that is, "induction" therapy at diagnosis with multiple agents followed by a maintenance phase of treatment might offer significant benefits to the patient. this open-label pilot study is the first to investigate the potential efficacy and safety of a first-line combination strategy in consecutive patients with pah in contrast to the "add-on" strategy for combination therapy. it will serve as the basis on which to consider larger, multicenter investigations of this strategy. 1. hoeper m, et al. eur respir j. 2005 nov;26(5):858-63. 2. halpern sd, et al. proc am thorac soc. 2008 jul 15;5(5):631-5. 3. provencher s, et al. chest. 2005 dec;128(6 suppl):622s-628s.

Eligibility criteria:
inclusion criteria: * patients with symptomatic functional class iii pah in the following categories: idiopathic (ipah), familial (fpah), associated with connective tissue disease, associated with drugs or toxins * pah diagnosed by right heart catheterization, defined as: mean pulmonary arterial pressure (mpap) ≥ 25 mmhg, pvr \> 3 mmhg/l/min (wood units) or \> 240 dyn sec cm-5, pulmonary capillary wedge pressure (pcwp) ≤ 15 mmhg * baseline 6 mwt distance \> 150 and \< 450 m exclusion criteria: * treatment with eras other than bosentan; * treatment with pde5 inhibitors other than sildenafil; * treatment with any prostanoid; * pah associated with thyroid disorders, glycogen storage disease, gaucher disease, hereditary hemorrhagic telangiectasia, hemoglobinopathies, myeloproliferative disorders and splenectomy; valvular disease with valvular lesions to be excluded by echocardiogram within 2 years prior to randomization * restrictive lung disease: total lung capacity (tlc) \< 60% of normal predicted value; * obstructive lung disease: forced expiratory volume/forced vital capacity (fev1/fvc) \< 50%
the effect of pharmacological antilipolysis on the metabolic effects of ghrelin

Conditions: Metabolism; Insulin Resistance; Hypopituitarism

Summary: this study will investigate the non-growth-hormone-dependent metabolic effects of the hormone ghrelin in growth hormone deficient subjects by examining the insulin tolerance as well as signal proteins in fat and muscle biopsies.

ghrelin is a relatively 'new' hormone that is produced in the stomach and to a lesser extend in the hypothalamus of the brain. the actions of ghrelin are diverse and includes stimulation of the appetite center of the brain and the release of growth hormone. we have for the first time shown that ghrelin also stimulates the metabolism of fatty acids and induces insulin resistance in skeletal muscle. these effects have we confirmed in growth hormone deficient subjects on a stabile substitution treatment with growth hormone and hydrocortisone. with these subjects we can investigate the effects of ghrelin that are independent of growth hormone. the present study is a continuation of these findings, as we wish to investigate whether the insulin resistance effect of ghrelin is dependent of the concomitant metabolism of fatty acids. this is possible by administration of the niacin acid antagonist acipimox, that blocks the fatty acid metabolism reversibly. we have applied this experimental principle in other settings with success. knowledge of the effects of ghrelin in general can in shot-sight as well as in long-sight have great importance for the understanding of growth disorders from overweight and type 2 diabetes to malnutrition and eating disorders.

Eligibility criteria:
inclusion criteria: * males with hypopituitarism in regard to growth hormone and acth in stabile treatment regime * age 18-65 * bmi 20-35 exclusion criteria: * abuse of alcohol * malign disease * medication other than that expected for hypopituitarism * known disease other than hypopituitarism * participation in isotope investigations the last 6 months

Keywords: ghrelin metabolism type 2 diabetes insulin resistance
a safety and efficacy study to evaluate romosozumab (amg 785) in south korean women with osteoporosis

Conditions: Postmenopausal Osteoporosis

Summary: the primary objective is to evaluate the effect of treatment with romosozumab for 6 months compared with placebo on percent changes in bone mineral density (bmd) at the lumbar spine as assessed by dual-energy x-ray absorptiometry (dxa) in postmenopausal women with osteoporosis.


Eligibility criteria:
inclusion criteria: * ambulatory postmenopausal korean women, ≥ 55 to ≤ 90 years of age at enrollment. * postmenopause is defined as no spontaneous vaginal bleeding or spotting for 12 or more consecutive months prior to screening. * bmd t-score \</= -2.50 at the lumbar spine, total hip or femoral neck. * at least 2 vertebrae in the l1 through l4 region and at least one hip are evaluable by dxa. * other inclusion criteria may apply. exclusion criteria: * subjects with a bmd t-score \</= -4.0 at the lumbar spine, total hip, or femoral neck. * history of hip fracture. * bone disease other than osteoporosis/ or evidence of any other clinically significant disorder, condition/ or disease or significant laboratory abnormalities. * known sensitivity or intolerance calcium and vitamin d products. * other exclusion criteria may apply.

Keywords: osteoporosis. osteoporosis-postmenopausal. bone diseases-metabolic. bone diseases. musculoskeletal diseases.
a comparison of diagnostic approaches for malaria and pneumonia

Conditions: Malaria; Pneumonia

Summary: this research investigates the diagnostic accuracy of various diagnostic approaches for malaria and pneumonia in under-five children presenting to primary healthcare centres in benin city, nigeria.

of the preventable and treatable diseases, both malaria and pneumonia are significant contributors to under-five mortality in nigeria. to reduce the burden of these diseases, the integrated management of childhood illness (imci) guidelines were developed by the world health organisation (who) to be used at first point of contact (e.g., primary healthcare centres) with children under the age of five years old. preliminary literature review suggests that although interventions based on numerous diagnostic approaches have been trialed, burden from malaria and pneumonia remains unacceptably high in nigeria, suggesting limited effectiveness of existing approaches. therefore, this study aims to compare the accuracy of different early diagnostic approaches used in the community(for e.g. the who integrated management of childhood illness (imci) guidelines versus the gold standard diagnostic tests comprising microscopy in malaria and chest radiography in pneumonia) in children under the age of five years presenting with suspected malaria and pneumonia to primary healthcare centres in benin city, edo state of nigeria. the research will compare the accuracy of these various diagnostic approaches using measures such as sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve. the research will also assess patient outcomes like complications, hospitalisation and death following a diagnosis of either pneumonia or malaria in all study participants as well as costs associated with malaria and pneumonia.

Eligibility criteria:
inclusion criteria: * suspected malaria (symptoms reported by caregiver that are consistent with malaria: high temperature, chills and no other probable diagnosis) * suspected pneumonia (fever, cough, shortness of breath/difficulty in breathing, with or without chills and no other probable diagnosis) * willingness of caregiver to provide written or verbal consent in the presence of a witness. exclusion criteria: none

Keywords: malaria pneumonia nigeria imci diagnosis
dart ii - a phase iv study of 3 antiretroviral medicines in combination, in hiv patients who have not been previously treated with antiretroviral therapy

Conditions: HIV Infections; AIDS

Summary: the purpose of this study is to evaluate whether a therapy with an all once daily regimen of stavudine extended release (d4t xr), lamivudine (3tc), and efavirenz (efv) leads to improved outcomes, as measured by viral load, cd4 counts, adherence, safety, and tolerability.


Eligibility criteria:
inclusion criteria: * patients 18 years of age or older infected with hiv and weigh at least 40 kg. * plasma hiv rna viral load of 1000 copies/ml or greater and cd4 count of 100 cells/ml or greater. * be willing to use two forms of contraception throughout study. * no previous exposure to antiretroviral (arv) drugs exclusion criteria: * pregnancy or breastfeeding * physical or psychiatric disability * proven or suspected acute hepatitis within 30 days prior to study entry * active aids-defining opportunistic infection or disease * history of acute or chronic pancreatitis

Keywords: hiv/aids
managing diabetes in pregnancy using cell phone/internet technology

Conditions: Diabetes During Pregnancy; Gestational Diabetes

Summary: to compare compliance and satisfaction between a traditional method of blood glucose reporting using voicemail (control) and a novel method using cell phone /internet (confidant) technology in the management of diabetic pregnant women.

control of blood glucose levels is beneficial during pregnancy, however, the ability to effectively monitor patient's blood glucose levels is challenging and time consuming for patients and care providers. patients must keep track of their own glucose levels and take the initiative to check blood glucose multiple times per day. traditionally, patients record their glucose levels in a logbook, which they bring with them during an office visit or use to report their glucose levels over the phone. non compliance and factitious reporting are not uncommon. obstetricians and or diabetes program staff spend hours communicating with patients to obtain and record glucose values therefore alternatives to phone calls are needed. investigators performed a prospective randomized cross over study comparing a conventional voicemail (control) system for home glucose reporting with a cell phone/internet reporting system (confidant). the primary outcome measure was compliance with home blood glucose fingerstick reporting. compliance was determined by the number of home glucose fingersticks reported / expected (%). the secondary outcome was patient satisfaction. subjects were participants in the kapiolani medical center for women and children's diabetes in pregnancy program known as "a sweeter choice". irb approval was obtained before starting the study and all subjects received informed consent. the study was funded by hawai'i medical service association, a medical insurance company in hawaii. the confidant equipment was supplied by hookele personal health planners, llc. none of the ho'okele or hawaii medical service association staff were involved in data collection or analysis. study subjects were randomized to confidant or the control system at the entry into the diabetes program during consultation with the maternal fetal medicine physician. after randomization, subjects performed the assigned monitoring system for 3 weeks. after three weeks, they switched to the other monitoring system. a satisfaction survey was completed after three weeks on the second system was completed.

Eligibility criteria:
inclusion criteria: -pregnant women \>=18 years with gestational diabetes or pregestational type 2 diabetes referred to the diabetes in pregnancy management program before 30 weeks 1 day gestation. exclusion criteria: * age less than 18 year * pregnancy \>=30 weeks 1 day * type i pregestational diabetes * inability to speak english
the role of adverse environment factors, family functioning and parental psychopathology in the response to treatment with methylphenidate in children and adolescents with attention deficit/hyperactivity disorder

Conditions: Attention Deficit Disorder With Hyperactivity

Summary: the purpose of this study is to investigate the association of adverse environmental factors, parental psychopathology, family functioning and genetic factors and the response to methylphenidate treatment in children and adolescents with attention deficit/hyperactivity disorder.

attention deficit/hyperactivity disorder (adhd) is a chronic disorder, with a worldwide estimated prevalence of 5,29%. it is associated with a high risk of functional impairment in many aspects of the patient´s life, such as academic achievements, peers relationships and physical injuries. there are few studies assessing predictive factors of clinical response to treatment. different patterns of family functioning, such as high family conflict and low family cohesion might be associated with a poor treatment response, possibly mediating the effects of higher severity af the disorder and/or higher prevalence of comorbidity. parental psychopathology has been associated with a poorer prognosis and is related with family functioning. adverse social factors have long been studied and are associated with an increased risk for general mental disease, including adhd, as well as a poorer prognosis. different genetic factors have been studied and associated with different aspects of the disorder and different clinical responses to treatments. there are no studies evaluating how those factors interact with each other in a brazilian population.

Eligibility criteria:
inclusion criteria: * adhd * age: 5 - 18 * primary indication of methylphenidate exclusion criteria: * iq \< 70 * clinical conditions that preclude use of methylphenidate

Keywords: attention deficit disorder attention deficit disorders with hyperactivity hyperkinetic syndrome family function adverse factors parental psychopathology
a comparison of immediate treatment of cin1 with cryotherapy and 12 month cytology follow up in hiv seropositive women

Conditions: Cervical Dysplasia

Summary: based on the high incidence of cervical cancer and high grade dysplasia and increased progression and incomplete treatment of cin2 and 3 in south africa, we propose to study the effect of cryotherapy among hiv-positive women diagnosed with cin 1 versus regular 12 month cytology follow-up. this study will be a dual-arm, open-label, randomized clinical trial for hiv-infected women diagnosed with cin 1 and receiving care at the themba lethu clinic, helen joseph hospital, johannesburg, south africa. cin 1 will be identified from patients who have had a colposcopic biopsy for persistent lsil as per standard of care.

women with hiv have a higher risk of cervical cancer. screening and treatment formaly of the disease is limited die to poor access of screening programs and multiple visits. women with hiv also have high progressions rates of disease amd my need to be treated earliers. cryotherapy is a low option and very easy to implement especially in low resource provinces. * it is cheaper and easier to administer than large loop electrosurgical excision procedure (lletz) * no histology or transportation costs of specimens * less invasive than lletz * it is nurse driven and easily learned * it decreases loss to follow-up of patients due to reduced waiting time, transportation costs, time off work and hiv stigma

Eligibility criteria:
inclusion criteria: * hiv -infected women whose biopsy proves cin1 and who consent to study participants and procedures * cin1 with no visible lesion * the entire ectocervical lesion should cover less than 75% of the cervix and not more than 2 - 3mm into the endocervical canal exclusion criteria: * pregnant women * known and previous treatment for hsil by any method (cryotherapy, leep or cone biopsy) * women who are menstruating or who have active pelvic inflammatory disease will be deferred from the study until the infection is cleared or the menstrual cycle has ended; the patient may then participate in the study. * unsatisfactory colposcopic examination defined as inability to see the extent of the lesion in the endocervical canal and lesions deemed ineligible for cryotherapy by an ob/gyn specialist. * previous hysterectomy with removal of the cervix

Keywords: cin1 hiv seropositive women cryotherapy
a study to assess the relative bioavailability and food effect of abi-h2158 in healthy adults

Conditions: Chronic Hepatitis B

Summary: this study is designed to assess the relative bioavailability of abi-h2158 tablets (test formulation) compared to abi-h2158 tablets (reference formulation). the effect of food on the pharmacokinetics of the test formulation will also be evaluated under fed and fasting conditions.


Eligibility criteria:
inclusion criteria: 1. no clinically significant abnormal findings on physical exam, medical history, or clinical laboratory results at screening. exclusion criteria: 1. positive test results for human immunodeficiency virus (hiv) or hepatitis b or c. 2. treatment for drug or alcohol dependence.
neuromuscular warm-up program for badminton players

Conditions: Balance; Distorted; Ankle Injury

Summary: this study aims to develop and evaluate a new warm-up program specifically designed for recreational badminton players. the program focuses on exercises that enhance balance and reduce the risk of ankle injury. participants will be asked to follow this warm-up routine, and their performance will be assessed before and after to see if the exercises improve their balance and overall movement. the goal is to create a practical, effective warm-up routine that can be easily incorporated into badminton practice.

this study investigates the effectiveness of a novel neuromuscular warm-up program tailored for recreational badminton players. the program is designed to improve balance, enhance movement efficiency and reduce the risk of injuries commonly associated with badminton. participants will be recruited from recreational badminton clubs and will undergo baseline assessments of balance performance and lunge movement using motion capture (mocap), emg. and inertia measurement unit (imu). the warm-up program includes a series of targeted exercises selected based on expert consensus from a previous delphi study. these exercises focus on key areas such as dynamic stability, and proprioception. participants perform pre and post test with star excursion balance test (sebt) and forward lunge movement with (imu, mocap and meg) attached on the lower limb. the intervention will be: 1) novel neuromuscular warmup and 2) traditional warmup. participants will perform both the warmup but on different days with one day rest in between the interventions. the study\&#39;s findings aim to inform best practices for warm-up routines in badminton, potentially offering a standardized program that can be widely adopted by recreational players to enhance their performance and safety on the court.

Eligibility criteria:
inclusion criteria: * injury free for \&gt;1 year, plays badminton minimum of once a week, have experience of playing at least 3 years exclusion criteria: * badminton players that participate in competition in any level (novice, intermediate or elite tier), involve in any regimented training, participants with any joint disorder, non-communicable diseases (ncd), neurologically unstable, consumption of any medication that can interfere with performance.

Keywords: recreational badminton balance improvement ankle injury prevention neuromuscular warm up warm up program