Kornimate/medical-research-clean huggingface dataset:
non small cell lung cancer evaluation according to pre-determined drug-targeting tumor markers

Conditions: Lung Cancer

Summary: evaluate chemotherapy related tumor markers on non small cell lung cancer by fluorescent in situ hybridization and immunohistochemistry, targets to be studied include egfr, c-met, topoisomerase ii, p53, topoisomerase i, thymidylate synthase, ercc1, tau, c-myc, rrm1, class iii tubulin. these targets have been chosen because they are targets for chemotherapeutic agents that are currently used in clinical management of these diseases. in total 50 specimen will be studied, approximately one third have mutations/deletions of the egfr gene.to attempt to establish a correlation between the pre-selected tumor markers and response to chemotherapy, and thus to be able to create a clinically useful classification that would provide clinical guidance for selection of the most effective chemotherapy for a individual patient, and thus be able to logically design more effective clinical trials for the future.


Eligibility criteria:
inclusion criteria: * patients with histologically confirmed lung cancer who received standard platinum-containing doublet chemotherapy followed by egfr tyrosine kinase inhibitors. exclusion criteria: * non

Keywords: lung cancer
radical cystectomy, nutrition and convalescence

Conditions: Urinary Bladder Neoplasms; Cystectomy; Bladder Cancer

Summary: the purpose of this study is to determine whether a goal directed nutritional intervention can reduce the convalescence period for patients undergoing radical cystectomy (rc). the aim is to examine the effect on quality of life of a standard nutritional strategy of resting the bowel till clear signs of bowel recovery and feeding orally after bowel recovery versus a goal-directed nutritional intervention combining oral intake and parenteral nutrition, in patients undergoing rc.

the study is a randomized controlled trial. inclusion criteria: bladder cancer, ability to give an informed consent. exclusion criteria: previous radiation therapy at the pelvic area, ureterocutaneostomy or robot-assisted surgery. the intervention aims to secure that 75% of the patient's total energy and protein needs are met during hospitalization. primary outcome: quality of life, using the eortc qlq-c30 and blm30 questionnaire. secondary outcomes: body-weight, hand grip strength, biochemical measures, length of hospital stay, time to bowel recovery. the follow-up period is 12 weeks. statistical analysis is performed in collaboration with a statistician.

Eligibility criteria:
inclusion criteria: * bladder cancer * ability to give an informed consent exclusion criteria: * previous radiation therapy at the pelvic area * ureterocutaneostomy * robot-assisted surgery

Keywords: quality of life enteral nutrition nutrition therapy parenteral nutrition, total
correlation between quadratus lumborum , pelvic floor muscles and diaphragm in patients with urinary incontinence

Conditions: Correlation Between Quadratus Lumborum , Pelvic Floor Muscles and Diaphragm in Patients With Urinary Incontinence

Summary: the purpose of this study is to investigate correlation between quadratus lumborum , pelvic floor muscles and diaphragm in patients with urinary incontinence

50 patients were distributed randomly into two groups. the first group measured ultrasound imaging for quadratus lumborum , pelvic floor muscles and diaphragm urinary incontinence female the second group measured ultrasound imaging for quadratus lumborum , pelvic floor muscles and diaphragm urinary incontinence female normal females. patients examined with medical ultrasound imaging .

Eligibility criteria:
inclusion criteria: * - their ages varied from 30to 40years, their body mass index (bmi) was 25-30 kg/m2 and a number of parities ≤ three normal vaginal deliveries, at least two years and subjects hadn't received drugs , urinary incontinence mild or modrate exclusion criteria: - 1. history of spinal surgery or spinal fracture. 2. volunteers with a history of a recto-vaginal or vesico-vaginal fistula, undiagnosed uterine bleeding urinary tract infection, diabetes, intrauterine device, chest and/or cardiac disease and using any drugs for urinary incontinence 3. serious diseases, such as heart disease, kidney, liver diseases, gastric ulcer or duodenal ulcer. 4. a history of bronchial asthma or any chest disease. 5. uncontrolled diabetes or hypertension. 6. patients with peacemaker or any metal implant on the treated area. 7. cancer or patient with past history of tumor excision.
changes in lab and ultrasonography after endoscopic varisceal treatment

Conditions: Liver Cirrhosis

Summary: laboratory and ultrasongraphicc changes after endoscopical varices treatment


Eligibility criteria:
inclusion criteria: * patients with liver cirrhosis and portal hyprtension with esophagel varisces exclusion criteria: * 1. patients with heart failure or renal failure 2. patients with copd 3. patients with hepato cellular carcinoma and portal vein thrombosis 4. pregnant
high-intensity laser therapy in patients with sacroiliitis

Conditions: Sacroiliac Arthritis

Summary: to investigate the effectiveness of high-intensity laser therapy (hilt) in reducing pain and improving function in patients with sacroiliitis, aged 40-60 years.


Eligibility criteria:
inclusion criteria: * age: adults aged 40-60 years old * diagnosis: confirmed diagnosis of sacroiliitis by a specialist (e.g., rheumatologist, orthopedic surgeon, or radiologist) based on a combination of clinical findings, laboratory tests, and imaging studies * clinical findings: presence of at least one or more of the following clinical signs and symptoms suggestive of sacroiliitis: 1. low back pain, buttock pain, or hip pain, worsened by prolonged sitting, standing, or walking 2. stiffness in the lower back, buttock, or hip region, particularly in the morning or following prolonged inactivity 3. pain improvement with physical activity or exercise * duration of symptoms: experiencing symptoms for at least 3 months exclusion criteria: * previous surgery or invasive procedures targeting the sacroiliac joints * contraindications to physical interventions (e.g., spinal instability, fractures, or severe neurological deficits) * presence of other spinal pathologies or systemic inflammatory conditions that could confound the assessment of sacroiliitis (e.g., lumbar disc herniation, ankylosing spondylitis, or rheumatoid arthritis) * pregnant or breastfeeding women
vildagliptin glycemic profiles assessment using a continuous glucose monitoring device.

Conditions: Type II Diabetes Mellitus

Summary: this study will use continuous glucose monitoring to assess differences in glycemic profiles between vildagliptin and glimepiride.


Eligibility criteria:
inclusion criteria: * type 2 diabetes patients on stable metformin * 18-70 years old * willing to perform at least 4 capillary blood glucose tests per day exclusion criteria: * type 2 diabetes patients on any other antidiabetic treatment * patients listed in other trials * patients with significant diabetic organ disease or complications. other protocol-defined inclusion/exclusion criteria may apply

Keywords: type ii diabetes mellitus vildagliptin glimepiride continuous glucose monitoring
open-label study of apx001 for treatment of patients with invasive mold infections caused by aspergillus or rare molds

Conditions: Invasive Fungal Infections

Summary: this is a phase 2, multicenter study to evaluate apx001 for the treatment of invasive fungal infections caused by aspergillus spp. or rare molds (eg, scedosporium spp., fusarium spp., and mucorales fungi).


Eligibility criteria:
inclusion criteria: * males or females, 18 years or older. * patients with proven or probable imi caused by aspergillus spp. patients who present with imi due to other filamentous fungi (eg, scedosporium spp., fusarium spp., and mucorales fungi such as mucor spp. or rhizopus spp.) may also be enrolled. * have limited or no treatment options due to documented or anticipated resistance, contraindication, intolerance, or lack of clinical response to soc antifungal therapy, as advocated by the relevant regional/country treatment guidelines. * patients where the investigator considers that there is a potential advantage of using apx001 over current soc (eg, broad spectrum of activity, emergence of imi during antifungal prophylaxis, activity against resistant mold pathogens, iv and po formulations, favorable ddi profile, favorable hepatic and renal safety profile, wide tissue distribution including brain), and/or where the soc antifungal therapy carries significant risk of toxicity or treatment failure (eg, ddi risk, safety/toxicity risk, site of infection not accessible by soc). exclusion criteria: * refractory hematologic malignancy. * chronic aspergillosis, aspergilloma, or allergic bronchopulmonary aspergillosis. * treatment with systemic (po, iv, or inhaled) mold active antifungal therapy for 120 hours immediately before initial dosing. note: patients with invasive fungal infection caused by a mold with documented resistance to or lack of coverage by the prior soc in question, may have received \>120 hours prior treatment and remain eligible for the study. * evidence of significant hepatic dysfunction.

Keywords: apx001 apx001a fosmanogepix manogepix aspergillus aspergillosis covid covid19 mold mould pulmonary aspergillosis pulmonary aspergillus galactomannan karius sars-cov-2 fusarium mucorales mucor rhizopus scedosporium fungal disease invasive fungal disease eortc
acupuncture and mindfulness based stress reduction for wellness

Conditions: PTSD

Summary: amwell is a randomized, waitlist-controlled, pilot study to evaluate the comparative efficacy of mindfulness based stress reduction (mbsr) and acupuncture (at) to wait-list control (wl) in adult female survivors of childhood sexual abuse (csa) experiencing symptoms of psychological distress.

female csa survivors at least 21 years old were recruited from newspaper ads, radio programs, study websites and various public announcements in the baltimore, md and surrounding area between september, 2008 to october, 2009.

Eligibility criteria:
inclusion criteria: * female survivors of childhood sexual assault reported in a clinical interview (e.g., age at which the abuse began and continued, frequency and duration, and the perpetrator) * at least 21 years old * ability to read and write in english * under the care of a licensed psychotherapist or physician for study duration * clinical approval for acupuncture or mbsd * ability to attend 80% of the sessions * willingness to practice skills 20-30 minutes per day, six days a week * if taking psychotropic medication, on a stable dose for 30 days prior to baseline * a score of 0.5 or greater on the brief symptom inventory (bsi) exclusion criteria: * any major illness or psychiatric disorder * symptom severity as evidenced by a cgi-s score of 6 or 7 * current suicidal ideation * active alcoholism or drug dependency * current enrollment in another clinical trial * major surgery scheduled * plans to move from the area during the 12-week study period * current pregnancy, plans to become pregnant, or no means of birth control

Keywords: ptsd depression acupuncture mindfulness-based stress reduction child abuse survivors
aspiration in acute respiratory failure survivors

Conditions: Dysphagia

Summary: the purpose of this study is to learn more about problems with swallowing that could develop in patients who are very sick and need a machine to help them breathe.

the purpose of this study is to learn more about problems with swallowing that could develop in patients who are very sick and need a machine to help them breathe. patients are asked to be in this study because they had problems breathing on their own and therefore needed the help of a machine called a ventilator. in order for this ventilator to push air into the lungs, patients need a tube placed in the throat called an endotracheal tube. the process of placing this endotracheal tube was called intubation. the tube has now been removed, which is a process called extubation. sometimes, people who have had endotracheal tubes can have difficulty swallowing food and liquids for a period of time. this disease is called post-extubation dysphagia (ped). ped is a serious condition and may result in food or liquid going from the mouth into the lungs. this could cause further lung problems. given this risk, doctors sometimes suggest that patients with ped either avoid eating or drinking, or get a feeding tube. currently, nobody knows how often patients develop ped, why they develop it, or the best method to detect it. standard care involves clinicians making educated guesses. this study looks to determine if watching the patient swallow, both with and without a small camera, is an accurate method for detecting ped.

Eligibility criteria:
inclusion criteria: * subjects will be eligible to participate in the study if they meet all of the following criteria: 1. admission to a university of colorado hospital icu 2. mechanical ventilation support through an endotracheal tube for greater than 24 hours exclusion criteria: * subjects will be ineligible to participate in the study if they meet any of the following criteria 1. age less than 18 years 2. contraindication to enteral nutrition administration 3. diagnosis of an acute or pre-existing central nervous system disorder (excluding a seizure disorder) 4. pre-existing dysphagia 5. previous surgery of the head, neck, or esophagus 6. previous cancer of the head or neck 7. the presence of a tracheostomy 8. the presence of nasal or pharyngeal trauma or bleeding 9. clinical team believes one of the protocols would be harmful to an individual patient 10. expected survival less than 3 months 11. pregnancy 12. imprisoned at the time of admission, anytime during the hospitalization, or anytime during the followup period 13. inability to give informed consent and proxy unavailable.
helicobacter pylori rescue treatment containing tetracycline in patients allergic to penicillin

Conditions: Helicobacter Pylori Infection

Summary: the purpose of this study is to assess and compare the effectiveness of furazolidone-tetracycline-containing and tinidazole-tetracycline-containing quadruple regimens for the rescue treatment of helicobacter pylori infection in patients allergic to penicillin.

helicobacter pylori(h.pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer. strongly evidence supports that h.pylori eradication is an effective approach to reduce the incidence of those pathologies.however,helicobacter pylori eradication is a challenge in patients allergic to penicillin. therefore, the investigators aim to assess and compare the effectiveness of furazolidone-tetracycline-containing and tinidazole-tetracycline-containing quadruple regimens for the rescue treatment of helicobacter pylori infection in patients allergic to penicillin.

Eligibility criteria:
inclusion criteria: * patients aged 18-70 with h. pylori infection. * patients with previous helicobacter pylori eradication. * patients allergic to penicillin. exclusion criteria: * patients treated with h2-receptor antagonist, ppi, bismuth and antibiotics in the previous 4 weeks. * patients with gastrectomy, acute gi bleeding and advanced gastric cancer. * patients with known or suspected allergy to study medications. * currently pregnant or lactating. * inability to provide informed consent and other situations that could interfere with the examination or therapeutic protocol.

Keywords: allergic penicillin rescue therapy tetracycline furazolidone
variability of spo2 measurements depending on the choice of finger for sensor placement

Conditions: Hypoxia; Hypercapnia

Summary: the aim of the project is to experimentally determine the effect of the choice of finger for the placement of a pulse oximeter sensor on the results of measuring peripheral blood oxygen saturation (spo2) in a healthy person with short-term hypoxia and hypercapnia.

the aim of the project is to experimentally determine the effect of the choice of finger for the placement of a pulse oximeter sensor on the results of measuring peripheral blood oxygen saturation (spo2) in a healthy person with short-term hypoxia and hypercapnia. this is an intervention prospective study that will take place at the faculty of biomedical engineering, especially on fbmi students. the experiment consists of two phases, in which in the first phase, the volunteers will inhale the hypoxic mixture for five minutes after the stabilization phase. in the second phase, volunteers inhale a hypoxic and hypercapnic mixture. during the experiment, non-invasive spo2 measurements will be performed continuously on individual fingers of both volunteer hands.

Eligibility criteria:
inclusion criteria: * passing the initial examination, which will determine the following data: finger circumference, heart rate, blood pressure and blood oxygen saturation exclusion criteria: * post-traumatic conditions of the upper limbs affecting the perfusion of the fingers or injuries or skin diseases on the fingers. * pneumothorax or a condition after cardiovascular surgery. * anemia, bradycardia, hemoglobinopathy or other diseases of the cardiovascular system, pregnancy, diabetes, hypotension or hypertension.
the u.k. embryologist fatigue study

Conditions: Fatigue; Stress; Burnout, Professional; Musculoskeletal Pain; Back Pain; Neck Pain; Headache; Dizziness; Sleep Disturbance; Chest Pain; Syncope; Cardiovascular Diseases; Shortness of Breath; Gastrointestinal Diseases

Summary: the purpose of the study is to determine physical and mental health issues of u.k. embryologists related to their occupational characteristics, and how workplace fatigue and burnout may affect their quality of life, cynicism, interactions with patients, attention to detail, and lead to human error, the cause of the most severe ivf incidents that often make headlines and result in costly litigation. it will also correlate how the current manual workflows contribute to these health issues, and what measures can be taken to improve both working conditions and embryologists' health, and, therefore, improve patient care.

embryologist fatigue surveys conducted in spain, the united states, and the international survey of embryologists from 85 countries reported that embryologists experience work-related fatigue, stress, and burnout. they named those as contributing factors to decreased efficiency, cynicism, and emotional exhaustion, which, together with having to handle the increasing cycle volume using conventional, manual protocols of cryomanagement, can lead to human error and ivf incidents. the known ivf incidents resulted in lost, damaged, or misplaced embryos and gametes, lawsuits, and reputational damage to patients and providers. in the absence of a "better than" cryopreservation storage solution, many programs just turned to buying more tanks and alarms and/or added expensive staff. the more effective solutions should focus on optimizing workflows by adopting innovation like automation and a digital chain of custody, organizational changes that will lead to a more productive, collaborative, and rewarding work environment, allowing embryologists to focus on patient care, scientific research, innovation, and career planning, and fewer incidents and lawsuits. the purpose of this cross-sectional study using a web-based survey is to determine physical and mental health issues of u.k. embryologists related to their occupational characteristics, and how workplace fatigue and burnout may affect their quality of life, cynicism, interactions with patients, attention to detail, and lead to human error, the cause of the most severe ivf incidents that often make headlines and result in costly litigation. it will also correlate how the current manual workflows contribute to these health issues, and what measures can be taken to improve both working conditions and embryologists' health, and, therefore, improve patient care.

Eligibility criteria:
inclusion criteria: * complete surveys from embryologists exclusion criteria: * incomplete surveys from embryologists; complete and incomplete surveys from non-embryologists.

Keywords: fatigue burnout stress occupational health occupational challenges
study of the reversibility of vigilance dysfunction at 6 months of continuous positive airways pressure (cpap) in patients with obstructive sleep apnea/hypopnea syndrome (osahs)

Conditions: Vigilance Dysfunction

Summary: it is a monocentric prospective pilot study in poitiers university hospital, specifically analyzing the vigilance disorders in the obstructive sleep apnea hypopnea syndrome (osahs) and their reversibility after 6 months of continuous positive airways pressure (cpap). all subjects were administered a test of vigilance (test of attentional performance) both before and after the 6 months of cpap. the main objective is the study of the reversibility of alertness disorders on the number of omissions in the subtest visual vigilance of the tap ( (test of attentional performance) at 6 months of cpap in the osahs in patients with a memory complaint.


Eligibility criteria:
inclusion criteria: * patients aged 20-70 years * memory disorders without memory problems in episodic memory * presence of polysomnography of a obstructive sleep apnea/hypopnea syndrome (osahs) requiring continuous positive airways pressure * moderate osahs (apnea hypopnea index ≥ 15 / hour with arousals ≥ 10) * severe osahs (apnea hypopnea index ≥ 30 / h) exclusion criteria: * age \<20 years or ≥ 70 years * neurodegenerative disease (alzheimer's disease, parkinson's disease) * dysthyroidism * severe depression, schizophrenia, bipolar disorder * treatment with an effect on cognition: hypnotics, sedative * chronic obstructive pulmonary disease * chronic alcoholism, other addictions * contraindications to magnetic resonance imaging * refusal of equipment