Kornimate/medical-research-clean huggingface dataset:
adalimumab in axial spondyloarthritis (asim) - mri and biomarkers in patients with spondyloarthritis

Conditions: Spondyloarthritis

Summary: investigation of wholebody mri and circulating biomarkers of inflammation, cartilage and bone metabolism in patients with spondyloarthritis treated with adalimumab. furthermore to compare ultrasound examination with wholebody mri etc.


Eligibility criteria:
inclusion criteria: * spondyloarthritis (spa) according to the new asas criteria for axial spa * basdai \> 40 mm despite nsaids * clinical indication for treatment with tnf-alpha inhibitor * age \> 18 years old and \< 85 years old * sufficient contraception for women * capable of giving informed consent * capable of complying with the examination program of the protocol exclusion criteria: * pregnancy wish, pregnancy or breast-feeding * dmards within 4 weeks prior to inclusion * oral, intra-articular or intramuscular glucocorticoid within 4 weeks prior to inclusion * the use of other study drugs within 4 weeks prior to inclusion or less than 5 half-lives of the study drug before inclusion if this is more than 4 weeks * the use of suspected disease-modifying or immunosuppressive drugs within 4 weeks prior to inclusion * dmards are allowed during the study, but the dose cannot be changed from 4 weeks prior to inclusion through week * contraindications for tnf-α inhibitor treatment * contraindications for mri * known recent drug or alcohol abuse * failure to provide written consent * incapable of complying with the examination program for physical or mental reasons

Keywords: patients with axial spondyloarthritis
postoperative atelectasis in pediatric patients with prone position

Conditions: Pulmonary Atelectasis, Postoperative; Atelectasis, Compression

Summary: this study evaluates the incidence of postoperative atelectasis after general anesthesia with prone position using lung ultrasound in children age \< 3 years.

atelectasis is common in pediatric patients after general anesthesia. particularly, infants are more likely to develop atelectasis or ventilation-perfusion imbalance after general anesthesia because of the immature ribs and respiratory muscles, the high compliance of the rib cage and a significant reduction in functional residual capacity (frc) during general anesthesia. previous studies have reported that alveolar recruitment and positive end-expiratory pressure (peep) can be used to reduce atelectasis in children. also, previous studies have shown that the lung ultrasound can be used to evaluate the degree of atelectasis during general anesthesia in children. however, none of the previous studies investigated the incidence of atelectasis, the effect of alveolar recruitment, and the peep in pediatric patients under general anesthesia with prone position. the purpose of this study was to evaluate previously described parameters using lung ultrasound.

Eligibility criteria:
inclusion criteria: * children undergoing general anesthesia with prone position * endotracheal intubation and mechanical ventilation during general anesthesia * operation time is more than 2 hours exclusion criteria: * previous lung surgery * any abnormal findings such as atelectasis, pneumothorax, pleural effusion, or pneumonia on preoperative chest x-ray * researchers judge (to be inappropriate)
study to evaluate the safety & tolerability of mrt5005 administered by nebulization in adults with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: this phase 1/2, first-in-human study will evaluate the safety and tolerability of single and multiple escalating doses of mrt5005 administered by nebulization to the respiratory tract of adult subjects with cf.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of cf as defined by both of the following: * two cf disease-causing cftr mutations in class i or ii (genotype confirmed at the screening visit). * chronic sinopulmonary disease and/or gastrointestinal/nutritional abnormalities consistent with cf disease. * clinically stable cf disease, as judged by the investigator. * fev1 ≥50% and ≤90% of the predicted normal for age, gender, and height at screening. * resting oxygen saturation ≥92% on room air (pulse oximetry). exclusion criteria: * an acute upper or lower respiratory infection, pulmonary exacerbation, clinically significant episode of hemoptysis or change in chronic respiratory medications (including antibiotics) for cf lung disease within 28 days prior to dosing with investigational product on day 1. * receiving treatment with ivacaftor monotherapy (kalydeco) * for all groups except daily dosing: receiving treatment with triple combination therapy (trikafta). * subjects with a class iii, iv, or v cftr gene mutation in at least 1 allele. * infection with highly virulent bacteria associated with accelerated decline in pulmonary function and/or decreased survival (e.g., burkholderia cenocepacia, burkholderia dolosa, mycobacterium abscessus). treatment with orkambi or symdeko is not an exclusion for this study.

Keywords: cystic fibrosis cf
use of selective jak inhibitor in ild and skin tightness of systemic sclerosis versus mmf

Conditions: Interstitial Lung Disease Due to Systemic Disease (Disorder)

Summary: systemic sclerosis (ssc) is a systemic autoimmune disease with heterogeneous clinical presentation and prognosis. jak inhibitors reduced cutaneous and pulmonary fibrosis in mice models of ssc. clinical data regarding the efficacy and safety of jak inhibitors in ssc patients are scarce

systemic sclerosis (ssc) is a systemic autoimmune disease with heterogeneous clinical presentation and prognosis. jak inhibitors reduced cutaneous and pulmonary fibrosis in mice models of ssc. clinical data regarding the efficacy and safety of jak inhibitors in ssc patients are scarce. upadacitinib mechanism of action jak-stat pathways are composed of four jak kinases and seven stats (stat1-6, including homologs stat5a and stat5b). a cytokine binding to its receptor initiates the signaling cascade as well as the subsequent association/rearrangement of the receptor subunits. this rearrangement enables jak activation by transphosphorylation and, upon activation, jaks phosphorylate the receptors.

Eligibility criteria:
inclusion criteria: * all patients are systemic sclerosis disease duration more than 3 years limited and diffuse types ground glass at hrct dlco\ 10% in last 12months exclusion criteria: * associated other ct diseases disease duration \< 3 years kidney disease

Keywords: ild
evaluating replacement of standard-of-care low dose computer tomography (ct) scans with radiation-free bone imaging by deep-learning augmented zero echo time (dl-zte) magnetic resonance tomography (mrt)

Conditions: Joint Diseases; Joint Inflammation

Summary: the goal of this clinical trial is to determine how effectively bone structures of the human skeleton can be visualized using deep learning (dl) augmented magnetic resonance imaging (mri) in individuals with inflammatory and degenerative joint changes, compared to computed tomography (ct). mri is a technique that operates without the use of x-rays. the main question it aims to answer is: 1. can dl mri accurately depict bone structures as well as ct? 2. can dl mri be used as an alternative to ct to avoid exposure to x-rays in the future? researchers will compare dl mri scans to ct scans to see if dl mri can effectively replace ct in visualizing bone structures without the use of radiation. participants will: 1. undergo mri scans of their skeletal system that will then be processed using dl. 2. undergo ct scans of the same body region for comparison purposes.


Eligibility criteria:
inclusion criteria: * referral for a clinically indicated mri examination of the musculoskeletal system to assess inflammatory and degenerative joint changes. * willingness to sign the informed consent form. * no contraindications for a ct examination (e.g., claustrophobia). exclusion criteria: * no signed informed consent form. * patients under 18 years of age. * pregnant women. * the calculated effective dose of the ct examination exceeds 5 msv.
crisaborole ointment for skin toxicity induced by cetuximab

Conditions: Metastatic Colorectal Cancer; Cetuximab; Skin Toxicity

Summary: this is a prospective, single-arm, phase ii clinical trial that will enroll metastatic colorectal cancer patients with cetuximab-related skin toxicity, who will receive crisaborole ointment twice daily.

the efficacy of cetuximab has been demonstrated in treating metastatic colorectal cancer (mcrc). skin toxicities, especially acneiform eruption, are the major side effects associated with cetuximab, which affect patients' quality of life and can lead to treatment discontinuation and cetuximab dose reduction. this prospective, single-arm, phase ii clinical trial aims to explore the efficacy and safety of crisaborole ointment in cetuximab-related skin toxicity. a total of 33 mcrc patients with acneiform eruption will be enrolled. all of the participants will receive crisaborole ointment twice daily. the total follow-up time is 12 weeks.

Eligibility criteria:
inclusion criteria: 1. diagnosed mcrc and undergoing cetuximab treatment; 2. ≥2 grade egfr inhibitor-related acneiform eruption, evaluated by national cancer institute (nci) common terminology criteria adverse events (ctcae）5.0; 3. age 18 years and older； 4. ecog performance status 0-2.； 5. bone marrow ,brain, heart, kidney and other organ function well;； 6. expected survival time more than 3 months; exclusion criteria: 1. the presence of any active skin disease； 2. undergoing any current hormone therapy for any other disease; 3. prior allergic reaction or severe intolerance to crisaborole ointment
addiction health evaluation and disease management (ahead) study

Conditions: Alcohol Dependence; Alcoholism; Drug Dependence

Summary: the objective of this study is to test whether a chronic disease management (cdm) program for substance abusers in primary care leads to improved alcohol and drug-related outcomes (such as reduced consumption and health problems) and health care utilization patterns.

chronic disease management (cdm) is a collaborative, longitudinal, proven effective approach to the treatment of chronic medical illnesses that addresses individual patient and health systems barriers to receipt of needed treatment. the objective of this addiction health evaluation and disease management (ahead) study is to test the effectiveness of cdm for substance dependence in primary care. the study will enroll and randomize subjects to attend a substance dependence cdm program (the ahead unit) integrated into a real-world primary care clinic or to referral to usual primary care. all subjects will be assessed regarding alcohol and/or drug diagnosis, consumption and problems, readiness to change, health-related quality of life, and medical and substance abuse treatment utilization. primary outcomes are alcohol and drug use, alcohol and drug-related problems, emergency department visits, and hospitalizations. additional outcomes are health-related quality of life, readiness to change, medical and psychiatric comorbidity, hiv risk behaviors, and treatment utilization and costs. the hypothesis is that compared with standard care, a health services intervention -- chronic disease management for alcohol and drug dependence integrated in primary care -- will decrease alcohol and drug use and related problems, and improve health care utilization patterns. this study contains two studies (and study populations): * 1. 320 alcohol dependent subjects with current risky drinking, and * 2. 320 drug dependent subjects with current drug use.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * fluent in english or spanish * alcohol or drug dependent * heavy drinking in the past 30 days or recent drug use * provide 2 contacts to assist with follow-up * have no plans to move from the local area within a year of screening * score \>21 on mini-mental state examination (no serious cognitive impairment) exclusion criteria: * pregnant (self-report) * breath alcohol \>100 mg/dl * inability to provide informed consent determined by trained research associates

Keywords: alcohol alcohol use alcohol dependence drug drug use drug dependence utilization hospitalization primary care chronic disease management care management comorbidity
hearty meals for mom- pilot study of meal delivery for cardiometabolic health during pregnancy

Conditions: Diet, Healthy; Pregnancy

Summary: this study is being done to assess the feasibility, acceptability, and preliminary impact of a meal delivery intervention designed to improve diet quality and promote appropriate gestational weight gain among predominantly black and low-income pregnant women with overweight or obesity. this will be done by 1) assessing the feasibility and acceptability of the meal delivery intervention; 2) investigating changes in patient-reported diet quality, barriers to healthy eating, and food security; and 3) exploring the preliminary impact of the meal delivery intervention on gestational weight gain and blood pressure and estimate the effect size of the intervention relative to a de-identified non-randomized control group that will be derived from de-identified hospital records.

subjects will receive 10 home-delivered meals per week from about 20 weeks gestation until 40 weeks gestation.

Eligibility criteria:
inclusion criteria: * medicaid eligible and/or have a household income at or below 185 percent of the federal poverty line * 18 years of age or older * \<= 19 weeks gestation * currently experiencing a singleton pregnancy * receiving prenatal care at a university of alabama at birmingham clinic * planning to deliver at the university of alabama at birmingham * residing within the meal company's delivery radius * body mass index \>= 25 * willing to consent exclusion criteria: * self-reported major health condition (such as renal disease, cancer, or type 1 or type 2 diabetes) * current treatment for severe psychiatric disorder (such as schizophrenia) * current substance abuse * self-reported diagnosis of anorexia or bulimia * known fetal anomaly * current use of medication expected to significantly impact body weight * planned termination of the current pregnancy * participation in another dietary and/or weight management intervention during the current pregnancy * unwilling or unable to understand and communicate in english * unwilling or unable to consume study meals

Keywords: meal delivery maternal overweight or obesity blood pressure food security pregnancy gestational weight gain
the impact of aromatherapy on alleviating dental anxiety in children

Conditions: Pain Syndrome

Summary: dealing with dental anxiety in children is the most problematic responsibilities for pedodontists in the dental office. essential oils had been used for reducing dental anxiety in adults; this study is a challenge to understand their effects on children. aromatherapy is considered as a reasonable, potent, safe, and non-pharmacological way, which has been taken into consideration, especially for children who are supposed to go through any dental procedure under local anesthesia. the aim of this study is to explore and compare the effect of rosemary versus lemongrass essential oils on dental anxiety levels and vital signs of children during dental anesthesia and extraction of a lower primary molar in a dental office. forty-five children, aged between 4 to 7 years, who had a minimum of one mandibular primary molar with deep caries indicated for extraction were selected. patients are divided, randomly, into three groups (15 children each): group i (control group): with no interference before dental anesthesia and extraction, group ii (rosemary group): children inhaled two drops of rosemary oil for 3 minutes before the procedures of dental anesthesia and extraction of a primary molar, group iii (lemongrass group): children inhaled two drops of lemongrass oil, for 3 minutes before the procedure of dental anesthesia and extraction of a primary molar. wong baker scale and the physiological measures of the children's anxiety will be evaluated and recorded for each child by measuring (pulse rate, oxygen saturation, and blood pressure) before, during and after the dental procedures.


Eligibility criteria:
inclusion criteria: * patients aged from six to nine years old * both girls and boys will be included. * patients who need extraction in at least one primary molar. * parents who will agree to contribute in the study. * patients with frankl behavior rating scale, categories 2, 3 and 4 exclusion criteria: * medically compromised patient * allergic children
neuropathic pain and traditional medicine syndromes in herpes zoster: a cross-sectional study

Conditions: Herpes Zoster (HZ); Traditional Chinese Medicine (TCM)

Summary: this study investigates the relationship between neuropathic pain characteristics and traditional chinese medicine (tcm) syndromes in patients with herpes zoster (hz). the study aims to integrate objective pain assessment tools, such as the leeds assessment of neuropathic symptoms and signs (lanss) scale, with tcm diagnostic classifications to enhance individualized treatment strategies. conducted at le van thinh hospital, vietnam, this cross-sectional study includes 80 hz patients, assessing their pain levels and corresponding tcm syndromes. the findings will contribute to a more comprehensive approach to pain management in herpes zoster.

this study is a cross-sectional and case series study conducted at le van thinh hospital, ho chi minh city, vietnam, between january and june 2024. it aims to evaluate the correlation between neuropathic pain characteristics and traditional chinese medicine (tcm) syndromes in patients with herpes zoster (hz). the study includes 80 participants diagnosed with hz, whose pain severity is assessed using the leeds assessment of neuropathic symptoms and signs (lanss) scale. the participants are classified into tcm syndromes based on standard diagnostic criteria, including liver meridian depression and heat syndrome (lmd), spleen deficiency and dampness retention syndrome (sda), and qi stagnation and blood stasis syndrome (qsa). the primary objectives of the study are: to determine the prevalence of different tcm syndromes in hz patients. to analyze the correlation between lanss scores and specific tcm syndromes. to provide insights into the integration of objective neuropathic pain assessment tools with traditional diagnostic frameworks. data collection includes demographic characteristics, medical history, pain characteristics, tcm diagnostic features, and clinical examination results. statistical analyses include correlation tests and multinomial logistic regression to assess the relationship between lanss pain scores and tcm syndromes. the study findings will contribute to a better understanding of the relationship between neuropathic pain and tcm syndromes in herpes zoster. the results may help refine diagnostic approaches and optimize integrative treatment strategies for pain management in patients with hz.

Eligibility criteria:
inclusion criteria: * adults aged ≥18 years * clinically diagnosed with herpes zoster (hz) based on european consensus guidelines * experiencing neuropathic pain associated with hz * willing to provide informed consent exclusion criteria: * history of chronic pain conditions unrelated to hz * receiving immunosuppressive therapy or diagnosed with immunodeficiency disorders * patients who had already received antiviral or analgesic treatment before evaluation * patients unable or unwilling to provide informed consent
proprioception of the knee post mis tka and mis-qs tka

Conditions: Osteoarthritis

Summary: if the proprioception of the affected knee post total knee arthroplasty (tka) can recover earlier, it will accelerate the regaining of motion control ability and motion control accuracy of the tka patients. this study compared the proprioception difference of the post operation knees between the mis-qs tka group and the mis tka group.the differences of proprioception recovery were analyzed following the two different tka procedures and the advantages of mis-qs tka in the recovery of knee. proprioception were discussed.

patients were scheduled prospectively to undergo total knee arthroplasties were randomly assigned to receive either a mis-qs tka or a mis tka. proprioception of the knee position sense was assessed by the knee angle reproduction test (10\~20 degree, 30\~40 degree, 80\~90 degree of the knee flexion) prior operation, and 1 week, 6 weeks, 3 months and 6 months post operation. paired two-tailed t tests with a level of significance of p \< 0.05 were used to assess the effect of the different arthroplasty procedure on the postoperative knee joint proprioception for all subjects.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of osteoarthritis * indication of tka exclusion criteria: * bilateral total knee replacements * rheumatoid arthritis * genu valgus over than 10 degrees and genu varum over 15 degrees * rom (range of motion) of preoperative knee joint less than 100 degree.

Keywords: surgical procedures minimally invasive arthroplasty knee