Kornimate/medical-research-clean huggingface dataset:
study of the safety and feasibility of psilocybin in adults with methamphetamine use disorder

Conditions: Methamphetamine Use Disorder; Substance-Related Disorders; Chemically-Induced Disorders; Substance Use Disorders; Stimulant-Use Disorder

Summary: the purpose of this research study is to investigate the safety and feasibility of two (2) oral doses of psilocybin when combined with behavioral support for methamphetamine use disorder (mud). participants have a diagnosis of methamphetamine use disorder (mud). participants can expect to be actively engaged in the study for up to 26 weeks.

the objective of this study is to determine the safety of psilocybin in adult participants with mud. eligible participants will be adults with methamphetamine use disorder recruited from the community. after physical and psychological screening, and at least 6 hours of psychological support for the psilocybin dosing, each participant will ingest 1 oral dose of psilocybin. all dosing sessions will be attended by 2 specially trained facilitators, in a dedicated session room at the university of wisconsin school of pharmacy. after eight hours of observation in the dosing room, the participant will stay overnight in the hospital clinical research unit, and complete an integration session with at least one of the session facilitators before discharge to home. approximately 4 weeks after the first dose, the participant will receive a second oral dose of psilocybin, with the same length of observation. participants who decide not to proceed to the second dose will complete two additional integration sessions and study measures through the two-month follow-up. if you are interested in participating in this study, please fill out a brief 1-minute survey at the link in the "more information" section at the bottom of this record.

Eligibility criteria:
inclusion criteria: * diagnosis of methamphetamine use disorder exclusion criteria: * positive urine pregnancy at any time point during screening or study participation * inadequately treated hypertension, defined as 2 blood pressure readings, 10 minutes apart, of greater than 140/90 mmhg systolic/diastolic * current acute coronary syndrome or angina * history of heart transplant or stroke * current use of and inability or unwillingness to taper off of medications that may interact with psilocybin * current insulin dependence, due to type i or type ii diabetes

Keywords: methamphetamine psilocybin psychedelics stimulants substance use
evaluation of the trumatch® system in knee prosthetic surgery

Conditions: Osteoarthritis, Knee

Summary: patient specific instrumentation is an alternative to conventional intra- and extra-medullary guides to perform the femoral and tibial cuts in total knee replacement (tkr). this instrumentation could provide a better alignment of a tkr, reduce blood losses and operative time, and improve clinical outcomes. the primary goal of this study is to compare the femorotibial mismatch angle of two groups of patients: patients undergoing posterior stabilized, fixed bearing tkr with conventional attune® instrumentation (depuy johnson \& johnson, warsaw, indiana), versus patient undergoing tkr with the trumatch® (depuy johnson \& johnson, warsaw, indiana) cutting guide.

good alignment after a tkr leads to faster rehabilitation, better clinical outcomes and lower revision rate. a correct rotational (axial) alignment reduces patellofemoral complications, polyethylene wear and unexplained knee pain. a randomized controlled study is conducted to test if to use the trumatch® (depuy johnson \& johnson, warsaw, indiana) patient specific instrumentation reduces the number of patients presenting femorotibial mismatch. secondary goals are to compare: * alignment in the coronal, sagittal and axial plane of the femoral component; * alignment in the coronal and sagittal plane of the tibial component; * number of recuts during surgery and surgeon's adherence to planning; * blood loss; * clinical outcome after two months using the oxford knee score (oks). after having signed informed consent, patients will be randomized in 2 groups preoperatively. a long-leg ct scan, according to manufacturer's instructions, will be performed on patients randomized to the trumatch® group. haemoglobin and haematocrit will be recorded pre- and postoperatively. two months after surgery a knee ct-scan, anteroposterior and laterolateral scanograms will be performed on all patients, and oks will be recorded.

Eligibility criteria:
inclusion criteria: * age \> 40, \<80 * indication for tkr * surgical indication for attune®, posterior stabilized, fixed bearing tkr * patients signed written informed consent exclusion criteria: * age \> 80, \< 40 * tkr revision surgery * metal devices within 8 cm from knee articular surfaces * fixed knee deformities greater than 15° in varus, valgus, flexion or tibial slope. * knee ankylosis * previous tibial osteotomy surgery * informed consent not accepted * serious comorbidity * active infections * pregnant or breastfeeding women

Keywords: total knee replacement patient specific instrumentation
alcohol drinking as a vital sign

Conditions: Unhealthy Drinking; Alcohol Dependence

Summary: the purpose of this study is to determine whether alcohol screening, brief intervention, and referral to specialty chemical dependency treatment (as appropriate) by non-physicians versus primary care providers (versus control group) is more likely to be implemented and more effective at reducing unsafe drinking.

this health services implementation study is a clustered, randomized trial. we propose to randomize primary care clinics to three arms-a control condition and two alternative modes of delivery of the niaaa clinician's guide to alcohol screening, brief intervention, and referral to treatment (sbirt) in primary care settings. in the primary care physician or "pcp" arm, pcps will be trained on the sbirt protocols outlined in the niaaa clinicians' guide and conduct brief intervention and referrals as needed. in the non-physician provider or "npp" arm, medical assistants will be trained to use the niaaa screener and enter the results in the electronic medical record, and npps (e.g., behavioral medicine specialists, clinical nurses and health educators) will conduct brief intervention and referral activities. the sbirt content, based on the niaaa guide, is the same in both the npp and pcp arms; we compare delivery by the two types of providers and versus the control condition, in which providers and staff will not receive any training on sbirt protocols. we examine implementation outcomes: rates of screening, brief intervention, follow-up screening and brief intervention, referral to chemical dependency treatment, and alcohol use disorders medication rates. we also include, as secondary analyses, an effectiveness study examining patient outcomes by study arm.

Eligibility criteria:
inclusion criteria: * patients: all patients aged 18+ who receive primary care visits in the kaiser permanente clinics in northern california. exclusion criteria: * patients younger than 18.

Keywords: alcohol dependence unhealthy drinking sbirt
plasma exchange vs conservative management in non-severe acute hypertriglyceridemic pancreatitis

Conditions: Acute Pancreatitis

Summary: to compare effectiveness in reducing triglycerides between daily plasma exchange and glucose+insulin infusion in patients with non-severe acute hypertriglyceridemic pancreatitis with mildly elevated triglycerides


Eligibility criteria:
inclusion criteria: * mild acute hypertriglyceridemic pancreatitis * triglycerides \>15 but \< 40 mmol/l exclusion criteria: * pregnancy * severe course of pancreatitis

Keywords: plasma exchange hypertriglyceridemia
labial biopsy in patients with tuberculosis disease

Conditions: Tuberculosis; Sarcoidosis

Summary: the distinction between tuberculosis disease (tb), a worldwide infective granulomatosis requiring long-term antibiotic treatment, and sarcoïdosis, a rare granulomatous disease successfully treated with high dose steroids is not straightforward and may delay the treatment choice by the physician. the goal was to evaluate prospectively and consecutively the presence of epithelioid granulomas in salivary glands biopsy of patients with tb.


Eligibility criteria:
inclusion criteria: * adults above 18 years, * bacteriologically confirmed tuberculosis exclusion criteria: * patient not able to sign written consent

Keywords: usefullness of labial biopsy to distinguish between tuberculosis and sarcoidosis
real-world comparative effectiveness of apixaban versus vitamin k antagonist

Conditions: Atrial Fibrillation

Summary: to obtain a better understanding on the comparative effectiveness of apixaban versus vka (vitamin k antagonist) for stroke prevention in patients with nvaf (non-valvular atrial fibrillation) in a real-life setting.


Eligibility criteria:
inclusion criteria: * nvaf will be defined as the occurrence of 2 or more inpatient or outpatient claims with icd-9 427.31 as the diagnosis code at any time in the patient's data history prior to inclusion * patients will be required to have 180 days of enrollment for the assessment of baseline characteristics * cha2ds2-vasc (c: congestive heart failure; h: hypertension; a2: age ≥75 years; d: diabetes mellitus; s2: prior stroke or tia or thromboembolism; v: vascular disease; a: age 65-74 years; sc: sex category) score ≥2 during the 180 days prior to index apixaban use baseline period exclusion criteria: * patients \<18 years of age * patients with valvular af (atrial fibrillation) * pregnancy * malignant cancers * transient cause of af * patients with vte (venous thromboembolism) (pulmonary embolism or dvt (deep vein thrombosis)) * patients with major surgery defined as hip or knee replacement * prescriptions of oacs (oral anticoagulants) (apixaban, warfarin, dabigatran, rivaroxaban) before index date * prescription of more than one oac on the index date * patient with any of the events defined in the composite endpoint

Keywords: non-valvular atrial fibrillation (nvaf) prevention stroke
etiology of diarrhea in guinea-bissau and in finland

Conditions: Diarrhea

Summary: diarrhoea is the leading cause of death in the world with 2.2 million deaths every year. the majority of deaths are among children in developing countries, but the travellers encounter the disease as well. the studies on the aetiology have suffered from serious methodological deficiencies and the results are even controversial. at the same time, the current diagnostic methods are inadequate. the investigators have recently developed novel multiplex rt-pcr methods to cover the majority of diarrhoeal pathogens. the present study is a collaboration between finland and sweden/guinea-bissau. the aim is to characterize the causative agents of diarrhoea (a) in finnish volunteers before and after a travel to tropical areas and, (b) in inhabitants of endemic areas in guinea-bissau. for these purposes stool samples will be collected from volunteers of different age groups and from healthy volunteers as well as those with diarrhea both in guinea-bissau and in finland. in addition to pathogens, other intestinal microbes and antimicrobial resistance will be investigated


Eligibility criteria:
inclusion criteria: 1. accepting to participate and willing to deliver 2 stool samples. 2. with diarrhea: the first 10 children and 10 adults presenting each month at the health facility without diarrhea: in bissau matched controls drawn from the registration system at bandim health project. in finland controls selected at the health facilities participating. exclusion criteria: * not willing or able to deliver the stool samples

Keywords: diarrhea guinea-bissau finland children adults intestinal pathogens bacteria virus parasites
effects of ginger on muscle soreness and dysfunction stemming from downhill running

Conditions: Muscle Soreness

Summary: the objective of the study is to determine whether five days of ginger (zingiber officinale) supplementation is effective at reducing muscle soreness and improving muscle function following downhill running. long-distance running is often associated with acute muscle pain, swelling, and reduced muscle functioning, and consequently, many runners utilize non-steroidal anti-inflammatory drugs (nsaid). nsaid use is associated with gastrointestinal side-effects such as stomach discomfort, nausea, dyspepsia, asymptomatic ulcers, and symptomatic ulcers that, although rare, can be fatal. ginger is a botanical compound that is generally recognized as safe by the food and drug administration (fda). evidence from osteoarthritis, dysmenorrhea, and resistance-training models indicate that ginger is effective at reducing general pain and muscle soreness. therefore, this study will supplement 60 runners with roughly 1.5 g/day of ginger root or a placebo for 2 days prior to, the day of, and 2 days after downhill running. participants will be evaluated for muscle soreness and function before and after the downhill run.


Eligibility criteria:
inclusion criteria: * be currently running ≥10 miles per week * have completed at least one run \>40 minutes over the past month exclusion criteria: * have no allergies to ginger * willing to avoid pain-relieving medications for the duration of the study * have no history of bleeding disorders nor currently taking blood thinners
an interventional multidisciplinary approach to individualize blood pressure treatment

Conditions: Uncontrolled Hypertension

Summary: the aim of the study is to investigate and explore the most important aspects of drug-adherence in the treatment of hypertension in order to improve treatment and blood pressure control, implying that new knowledge will reduce morbidity and mortality.


Eligibility criteria:
inclusion criteria: * signed informed consent * uncontrolled hypertension * a stable medication regimen for at least 4 weeks of ≥ 2 antihypertensive agents * no planned changes in antihypertensive drugs exclusion criteria: * withdrawal of consent * 24-h systolic ambulatory blood pressure \>/= 170 mmhg * patients with inadequate norwegian language skills * positive pregnancy test * known alcohol or drug abuse * estimated glomerular filtration rate \<30 ml/min/1.73m2 * albumin/creatinin ratio \>300 mg/mmol * any reason why, in the opinion of the investigator, the patient should not participate

Keywords: adherence therapeutic drug monitoring patient perspective
effects of shock wave therapy in women with pain in trapézio muscle

Conditions: Pain; Muscle Tonus

Summary: the study consisted of 60 women who had pain-point pains in the upper fibers of the trapezius muscle. they had a medical age of 22.8 years, with a body mass index of 22.8 kg / cm2.they underwent an initial assessment, with a visual analogue pain scale, followed by an assessment of pain threshold, and manual muscle strength.then, they were allocated into three groups: control group with 20 volunteers without intervention, placebo group with 20 volunteers with shock wave simulation and an intervention group with 20 volunteers with shock wave therapy. all volunteers were evaluated immediately after the protocol (post evaluation) and 48 hours after the intervention protocol (48 hour evaluation). a mixed anova of repeated measurements was used for intra and intergroup comparisons, followed by tukey post hoc. significance was set at 5% (p \<0.05).

the objective was to investigate the effects of shock wave therapy on the pain of trigger points in the upper fibers of the trapezius muscle. a randomized, blinded clinical trial of 60 women (mean age 22.8 years and mean body mass index of 22.8 kg / cm2) with presence of trigger points in the upper fibers of the trapezius muscle. these were submitted to an initial evaluation (av1), composed of the visual analogical pain scale, followed by an evaluation of the pain threshold, using algometry. then, the evaluation of the electromyographic activity of the upper trapezius muscle was performed, as well as of its muscular strength by manual dynamometry. then allocated randomly in 3 groups: control (n = 20), without intervention; placebo (n = 20), simulation of the application of shock wave therapy; and shock wave therapy (n = 20). shock wave therapy was performed with the master plus 200® storz medical equipment, radial emission 2000 pulses, 15 hz frequency and pressure of 1 bar. all volunteers were evaluated immediately after the protocol (post evaluation) and 48 hours after the intervention protocol (evaluation 48 hours). a mixed anova of repeated measurements was used for intra and intergroup comparisons, followed by tukey post hoc. significance was set at 5% (p \<0.05).

Eligibility criteria:
inclusion criteria: * women with painful symptoms, compatible with the referred pain pattern of trigger points in the upper trapezius muscle. * age range of 18 to 35 years. * no upper limb injury in the last 6 months. * featuring trigger points identified in the upper trapezius muscle. * present pain and / or moderate and / or severe disability after application of specific instruments. exclusion criteria: * present unbearable pain during the evaluation procedures. * missing or not executing the solution correctly.

Keywords: high energy shock waves physiotherapy
comparing the clinical characteristics of male lada, t1dm and t2dm patients

Conditions: Diabetes

Summary: diabetes is a common chronic disease in most parts of the world. diabetes-related complications are harmful to the human body. different types of diabetes have different levels of harm to the human body. there are also fewer studies on the relationship between specific types of diabetes and clinical diseases such as osteoporosis and hypogonadism. therefore, clarifying the differences in the clinical characteristics of adult men with late-onset autoimmune diabetes (lada) ,classical type 1 diabetes (t1dm) and type 2 diabetes (t2dm) will help to further understand the effects of diabetes on bone metabolism and sex hormones.

diabetes is a common chronic disease in most parts of the world. diabetes-related complications are harmful to the human body. there are also fewer studies on the relationship between specific types of diabetes and clinical diseases such as osteoporosis and hypogonadism. this study aimed to compare the prevalence of hypogonadism and osteoporosis among male patients with latent autoimmune diabetes (lada), type 1 diabetes (t1dm) and type 2 diabetes (t2dm) and investigate the protective factors for hypogonadism and osteoporosis in these patients. this cross-sectional study evaluated male patients with lada, t1dm, and t2dm who visited the endocrinology department of shanghai tenth people's hospital for diabetes management. sex hormones, lipid profiles, sex hormone-binding globulin (shbg), glycosylated hemoglobin a1c, beta-cell function, uric acid, and osteocalcin were determined in serum samples. therefor，clarifying the differences in the clinical characteristics of adult men with lada, t1dm and t2dm will help to further understand the effects of diabetes on bone metabolism and sex hormones.

Eligibility criteria:
inclusion criteria: 1. 30 \~ 80 years old male; 2. meet the american diabetes association (ada) definition and standards for diabetes exclusion criteria: 1. having diseases that affect bone and calcium metabolism, such as hyperthyroidism, hyperparathyroidism, hypogonadism, cushing syndrome, rheumatoid arthritis, cirrhosis, or malignant tumor; 2. the use in the past 6 months of drugs that interfere with bone and calcium metabolism, such as sex steroids, vitamin d metabolites, calcitonin, bisphosphonates, and thyroid hormone; 3. moderate or severe liver and renal dysfunction, including serum alanine aminotransferase of 120 iu/l, aspartate aminotransferase of 80 iu/l, and serum creatinine of 120 μmol/l. 4）a history of congenital/hypogonadotropic hypogonadism or hyperthyroidism, or those who received testosterone replacement therapy in the past 6 months were excluded.
transforming hypertension treatment in nigeria using a type ii hybrid, interrupted time series design

Conditions: Hypertension

Summary: the purpose of the transforming hypertension treatment in nigeria program is to improve awareness, treatment, and control of hypertension in nigeria through the adaptation, implementation, and evaluation of the effectiveness and implementation of a system-level hypertension control program.

this study includes the implementation and evaluation of a culturally- and contextually-adapted intervention package based on the kaiser permanente northern california and world health organization hearts programs for hypertension diagnosis and treatment at primary health centers in abuja, nigeria. the intervention has been adapted based on a local needs' assessment including evidence synthesis and specific exploration of health care workers' knowledge, attitudes, and behaviors related to hypertension, causes, consequences, and treatment, including fixed-dose combination and patient self-management, and patients' knowledge, attitudes, and behaviors related to hypertension, causes, consequences, and treatment. implementation pathways have been developed with particular attention to overcoming modifiable system- and patient-level barriers to hypertension treatment and control across capability, intentional, and system domains using the consolidated framework for implementation research. preparedness and capacity have been assessed at primary health centers (e.g. available staff; information systems; use of clinical guidelines) through an adapted service availability and readiness assessment (sara) instrument during the formative work for this study. the multi-level implementation package includes: 1) patient registration and empanelment (health system level), 2) standard treatment protocol (national policy level), 3) encouragement of fixed-dose combination therapy (health system level), 4) team-based care (health worker level), and 5) home blood pressure monitoring and health coaching (patient-level).

Eligibility criteria:
inclusion criteria: * adults (≥18 years). * elevated blood pressure (systolic blood pressure ≥ 130 mmhg or diastolic blood pressure ≥ 80 mmhg) documented or measured by a health care professional (e.g., physician, community health extension worker, or community health officer). exclusion criteria: * individuals who are not yet adults (minors) * prisoners or other detained individuals.

Keywords: hypertension nigeria primary health center