Kornimate/medical-research-clean huggingface dataset:
project healthy eating in children. a study on the health effects of fish intake in overweight children

Conditions: Healthy

Summary: it has previously been seen that increased fish intake improves the metabolic health of overweight and obese adults, and animal protein improved metabolic health of obese rats. in this project the investigators will investigate whether increased intake of fish or meat improve metabolic health in children aged 9-12 years as well when replacing processed food. the hypothesis is that increased intake of unprocessed fish or meat will improve metabolic health in children as measured by glucose tolerance, lipid metabolism and inflammatory markers.


Eligibility criteria:
inclusion criteria: * overweight (iso-bmi \> 25) * 9-12 years * healthy exclusion criteria: * diagnosed diseases such as diabetes, cvd, intestinal diseases, arthritis * prescription medications affecting the metabolism of glucose, lipids or the immune system * use of supplements containing long chain n-3 fatty acids * high intake of fish * food allergy

Keywords: children age 9-12 years overweight (iso-bmi > 25)
early oral feeding versus traditional delayed oral feeding post-perforated peptic ulcer repair

Conditions: Peptic Ulcer Perforation

Summary: this study aims to evaluate safety and benefits of early oral feeding compared to traditional delayed oral feeding in patients undergoing perforated peptic ulcer repairs. study population \& sample size :(

study design: this study is a single-center, prospective, parallel arm, randomized controlled trial. patients will be randomly assigned in 1:1 ratio to receive either delayed oral feeding or early oral feeding. methods: patients will be randomly assigned into two groups. group a patients followed an early oral feeding protocol(12 hours), and group b received delayed oral feeding (72 hours). outcome parameter : the outcomes are incidence of postoperative complications including postoperative repair leakage, infection-related postoperative complications , number of days of hospital stay and return of bowel function and diet intolerance.

Eligibility criteria:
inclusion criteria: - all consecutive patients, of age 18 years and above, who were presented to the emergency surgical team and were diagnosed with perforated duodenal ulcer by surgicalteam, were recruited and assessed for eligibility. exclusion criteria: * • preoperative refractory septic shock on admission. * delayed presentation more than 24 hours. * the presence of neuropsychiatric disease, pregnant and lactating women. * predisposing factors for impaired wound healing (e.g., currently using immunosuppressive agents, or chronic use of steroids), the presence of hiv. * american society of anesthesiologists grade iii/iv, or had an alternative perioperative diagnosis. * intraoperatively, after randomization, patients were excluded based on the following criteria: perforated duodenal ulcer ≥20 mm, consistent with malignant ulcers.
the effects of upper extremity lymphedema on posture, upper extremity functions, and quality of life

Conditions: Breast Cancer Related Lymphedema; Breast Cancer-Related Arm Lymphedema

Summary: this study aims to examine the effects of lymphedema extremity on upper extremity function, posture and quality of life in patients who develop upper extremity lymphedema after unilateral breast cancer. twenty-seven volunteers (27female) diagnosed with upper extremity lymphedema after unilateral breast cancer treatment by a specialist physician between may 2022 and october 2022 were included in the study. upper extremity circumference measurements of the individuals were performed on the healthy and affected sides. a goniometer measured both sides' upper extremity range of motion (rom). the new york posture analysis (nypa) was used for posture evaluation. upper extremity functions were assessed by the disabilities of the arm, shoulder and hand (dash) questionnaire and the lymphedema functionality, disability and health questionnaire (lymph-icf). quality of life was assessed by upper extremity lymphedema-27 (ull-27) and quality of life measure for limb lymphedema -arm (lymqol- arm).

this study aims to examine the effects of lymphedema extremity on upper extremity function, posture and quality of life in patients who develop upper extremity lymphedema after unilateral breast cancer. twenty-seven volunteers (27female) diagnosed with upper extremity lymphedema after unilateral breast cancer treatment by a specialist physician between may 2022 and october 2022 were included in the study. upper extremity circumference measurements of the individuals were performed on the healthy and affected sides. a goniometer measured both sides' upper extremity range of motion (rom). the new york posture analysis (nypa) was used for posture evaluation. upper extremity functions were assessed by the disabilities of the arm, shoulder and hand (dash) questionnaire and the lymphedema functionality, disability and health questionnaire (lymph-icf). quality of life was assessed by upper extremity lymphedema-27 (ull-27) and quality of life measure for limb lymphedema -arm (lymqol- arm). the hypotheses of our study: hypothesis 0 (h0): there is no relationship between upper extremity function, posture and quality of life in patients with upper extremity lymphedema after unilateral breast cancer treatment. hypothesis 1 (h1): there is a relationship between upper extremity function, posture and quality of life in patients with upper extremity lymphedema after unilateral breast cancer treatment.

Eligibility criteria:
inclusion criteria: * volunteering to participate in the research * be between the ages of 18-50 * having had unilateral breast cancer * at least one year since breast cancer treatment * no active metastases exclusion criteria: * arthritis * fibromyalgia syndrome * neurological diseases * mental illnesses * myopathic diseases * bilateral upper extremity lymphedema * inability to communicate and cooperate * presence of any orthopaedic disease in the affected upper extremity * having scoliosis * having cognitive problems
quality of life in thai women diagnosed cervical cancer at king chulalongkorn memorial hospital

Conditions: Quality of Life; Cervical Cancer; Cervical Intraepithelial Neoplasia

Summary: to study the quality of life of patients earlier diagnosed for cervical cancer and cervical intraepithelial neoplasia (cin).

in thailand, age standardized incidence is 20.9 per 100,000 women-year. treatment-related survival gain are experienced by side-effect that may reduce quality of life (qol). we therefore, study the quality of life of patients earlier diagnosed for cervical cancer patients.

Eligibility criteria:
inclusion criteria: * thai patients * aged more than 15 years old. * diagnosed of cervical intraepithelial neoplasia (cin) or cervical cancer with pathological confirmation. if she has more than one diseases, the most severe will be considered as diagnosis. * not suffered from confusion or reduced level of consciousness or unable to communicate. exclusion criteria:
strength training to improve gait in people with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: this study will pilot a strengthening intervention targeted to muscles found to be important to gait in people with multiple sclerosis (ms). previous studies that have tried to strengthen leg and trunk muscles in people with ms have failed to improve walking ability consistently. the investigators think that is because strengthening exercises were not targeted to the correct muscle groups. for this study the investigators propose targeting muscle groups that they have found to be strong contributors to walking in a prior study. this is the first study to target these muscles, so the investigators propose doing a small trial to first evaluate the feasibility of the strength program and the outcomes. the investigators will measure strength and walking measures twice before and once after an 8-week strengthening intervention in a single group of 10 people with ms who are able to walk independently. the results of this study will help inform future, larger trials that could change the way strength training is conducted in people with ms.


Eligibility criteria:
inclusion criteria: 1. people with ms, 2. age 18-65, 3. a confirmed diagnosis of ms, and 4. are ambulatory for 100m without an assistive device (edds 0-5.5), and 5. have a gait speed measured by time to walk the 25-foot walk test of at least five seconds. exclusion criteria: 1. subjects are not ambulatory, 2. subjects rely on a wheelchair, 3. subjects cannot ambulate 100m (edds 6 or greater) without use of assistive devices, braces, or orthotics, 4. walk the t25fw in less than five seconds, 5. have lower extremity spasticity of 2 or greater on the modified ashworth scale (mas), 6. have pain or other conditions that limit ambulation or ability to test muscle strength, 7. cannot give consent, 8. cannot follow simple directions, 9. have had an exacerbation in the past month, 10. have had changes to their drug therapy in the last month, 11. have other neurologic diagnoses, or 12. are currently undergoing physical therapy for strength training.

Keywords: rehabilitation physical therapy
transcranial magnetic stimulation for borderline personality disorder

Conditions: Borderline Personality Disorder

Summary: primary purpose : to assess the effect on neuropsychological tasks related to planning of 10 daily sessions of right dorsolateral prefrontal cortex with high-frequency repetitive transcranial magnetic stimulation (rtms) on borderline personality disorder (bpd) patients. hypothesis : bpd patients receiving 10 sessions of rtms will have greater improvement in the average number of move to achieve tasks of the tower of london, than those receiving sham rtms.


Eligibility criteria:
inclusion criteria: * 20 to 45 years old * borderline personality disorder (diagnostic interview for borderline personality disorder \> 8) * psychiatric follow-up * righthander * informed consent * affiliated to medical insurance exclusion criteria: * bipolar disorder * substance use disorder * major depressive disorder or stress post traumatic disorder * history of epilepsy * neurosurgery * cardiac pacemaker * lefthander * involuntary admission * participation in an other research * legal guardianship * poor mastery of french.

Keywords: borderline personality disorder transcranial magnetic stimulation neuropsychological test randomised control trial
effects of atorvastatin versus probucol on small dense ldl

Conditions: Chronic Nephropathy

Summary: small dense low-density lipoprotein (ldl) plays an important role in causing glomerular injury through conversion to an oxidatively modified form of ldl. however, few studies evaluated the effects of antilipidemic agents on the ldl particle size and renoprotective actions in hyperlipidemic patients with non-diabetic nephropathy.

the study is a randomized crossover trial comparing the effect of atorvastatin (10 mg/day) and probucol (500 mg/day) for 24 weeks in 30 patients (urinary albumin excretion 0.3-2.0 g/day, and creatinine clearance \> 30 ml/min/1.73 m2 or serum creatinine concentration \< 2 mg/l). lipid parameters, mean ldl particle diameter, creatinine clearance, and urinary albumin to creatinine excretion ratio are measured before and during treatment periods. it will be evaluated that, first, whether atorvastatin and probucol significantly reduce serum total cholesterol and ldl cholesterol concentrations, second, whether atorvastatin and probucol significantly increase the ldl particle size, third, whether significant differences in urinary albumin/creatinine excretion ratio and creatinine clearance are observed in both groups during treatment.

Eligibility criteria:
inclusion criteria: * hyperlipidemic patients with non-diabetic nephropathy exclusion criteria: * endocrinological, hematological or hepatic disease * cerebral infarction or hemorrhage * homozygous familial hypercholesterolemia * uncontrolled hypertension * myocardial infarction occurring within the previous 6 months * unstable angina * diabetic nephropathy * abnormal thyroid function * receiving steroids or immunosuppressive agents

Keywords: small dense ldl
the efficacy of oral cryotherapy in preventing trop2-adc-induced oral mucositis in patients with advanced breast cancer

Conditions: Advanced or Metastatic Breast Cancer

Summary: the incidence of oral mucositis associated with trop2-adc therapy in patients with advanced breast cancer is notably high. identifying effective preventive and therapeutic strategies is essential for enhancing patient quality of life and optimizing treatment outcomes. oral cryotherapy has been demonstrated to be efficacious in mitigating oral mucositis induced by radiotherapy and chemotherapy. consequently, this study seeks to investigate the potential preventive efficacy of oral cryotherapy on trop2-adc-induced oral mucositis in patients with advanced breast cancer


Eligibility criteria:
inclusion criteria: 1. participants voluntarily enrolled in the study, signed the informed consent form, and demonstrated good compliance. 2. age ≥ 18 years at the time of informed consent signing. 3. patients with locally advanced or recurrent/metastatic breast cancer receiving trop2-adc treatment for the first time. 4. ecog ps: 0-2 points; 5. the expected survival time was more than 3 months; 6. adequate organ and bone marrow function, with no transfusions or treatments with recombinant human thrombopoietin or colony-stimulating factors within 1 week before the first dose, is defined as follows: 1. blood routine: neutrophil count (neut#) ≥ 1.5×109/l; platelet (plt) ≥ 75×109/l; hemoglobin ≥ 90g/l 2. liver function: ast and alt ≤ 3 × uln; for patients with liver metastasis, ast and alt ≤ 5 × uln. 3. renal function: creatinine ≤ 1.5 × uln or ccr ≥ 60 ml/min (cockcroft-gault formula provided). 4. cardiac function: lvef ≥ 50% by echo or muga scan. 7. patients with a negative pregnancy test and reproductive potential must agree to use effective non-hormonal contraception during treatment and for at least 3 months after the last dose of the investigational drug. 8. voluntary participants who sign informed consent, demonstrate good compliance, and agree to follow-up. exclusion criteria: 1. prior trop2-targeted treatment was administered. 2. patients with active oral mucositis or oral ulcers were excluded. 3. patients with serious concomitant diseases, as judged by researchers, that threaten safety or impede study completion, including uncontrolled hypertension, severe diabetes, and active infections, were excluded. 4. other conditions where the investigator determines the patient is unsuitable for study participation.
parenting with anxiety: helping anxious parents raise confident children

Conditions: Child Anxiety; Parent Anxiety; Parental Wellbeing; Child Wellbeing

Summary: this is a randomised controlled trial of an intervention to reduce symptoms of anxiety in the children of anxious parents. parents will participate in an online intervention which helps them develop a calm, consistent, behaviour management style. the parents will be randomised to the intervention or a control group with no intervention. the intervention itself will undergo a component analysis to determine whether some modules are more effective than others.

the study is an online course (derived from an existing evidence-based face-to-face workshop designed and evaluated by the c.i) which aims to reduce symptoms of anxiety in the children of anxious parents. it is a learning tool to help parents to understand the basic processes involved in children's anxiety, to develop a calm, consistent, behaviour management style and to learn skills for responding to difficult emotion in their children. the whole study takes place online, allowing the participants to sign up, run through some brief eligibility questions, read the study information and provide consent. once enrolled in the study, there is a series of baseline questionnaires. the participant also has the option to nominate someone who also knows their child well (e.g. a co-parent, a family member or close friend) to participate in the study with them and to complete a small number of questionnaires. this will help to give us a broader, more objective picture of the child, but is an optional part of the study. 48 hours later (to allow time for the participants to contact the co-respondent if they choose) the index participant will be randomised to one of two groups: either the intervention (the online course), or the control group where they do not receive the intervention. those in the intervention will be randomised to receive 8 out of 9 modules of the course, with a suggested time frame of one or two modules a week, each module taking about 30 minutes, with some home-practice tasks in-between. both the intervention group and the control group participants will be contacted again after 6 months to complete a set of follow-up questionnaires (similar to those completed at baseline). depending on when each participant joins the trial, they may be contacted a third time towards the end of the life of the study, to complete another set of questionnaires,9-21 months after their first.

Eligibility criteria:
inclusion criteria: * be a parent (any gender, adoptive/biological/step/foster/grandparent) aged 16+, of a child aged 2 to 11 years (inclusive). the index parent must have at least 50 days' contact with the index child per year and confirm that they see enough of the child to report on the child's current anxiety level. * index parent must be a uk resident. * self-report subjectively substantial levels of current or lifetime anxiety. * able to commit to completion of measures at (up to) three time points even if allocated to the control arm. exclusion criteria: * n/a

Keywords: parenting
study evaluating betaferons safety and tolerability in pediatric patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: multiple sclerosis (ms) is mainly known as a disease of young to middle adulthood but approximately 5% of all ms cases worldwide involve children that are younger than 16 years. the aim of care of children with multiple sclerosis is to prevent or at least to delay any neurological and cognitive impairment as well as progression of the disease as far as possible. therefore, it is very crucial to diagnose the disease at an early stage as immunomodulatory treatments are available that can delay the progression of multiple sclerosistreatment with the immunomodulatory agent betaferon® in children diagnosed with rrms and being 12 years or older has been approved by the health authorities. the aim of this observational study is to obtain further data on the safety, tolerability, and effectiveness of betaferon® under daily living conditions. as this is a non-interventional observational study, routine clinical practice is observed. the application of diagnostic measures and medications as well as physician visits follow the normal routine and is decided upon by the treating physician under recognition of the package insert.


Eligibility criteria:
inclusion criteria: * treatment naive children and adolescents of 12 to 16 years of age at inclusion with a diagnosis of rrms according to revised mcdonald or poser criteria and decision taken by the investigator to treat with betaferon. the local betaferon product information must be considered. exclusion criteria: * contraindications stated in the local betaferon product information; warnings and precautions must be considered.

Keywords: multiple sclerosis ms non-interventional
effect of beta-alanine and pelvic floor muscle training on urinary incontinence after radical prostatectomy (bela)

Conditions: Prostate Cancer; Urinary Incontinence; Beta-Alanine; Pelvic Floor Muscle Training; Radical Prostatectomy

Summary: the purpose of this study is to evaluate the effectiveness of beta-alanine in combination with pelvic floor muscle training (pfmt) compared to pfmt plus placebo in men undergoing radical prostatectomy.

this study will assess efficacy of beta-alanine in combination with pfmt for the treatment of participants with urinary incontinence after radical prostatectomy. b-alanine is a component of l-carnosine (with l-histidine), which is needed for its synthesis. βeta-alanine, thanks to its bioavailability) is a commonly used supplement that can improve exercise performance by increasing the amount of carnosine in striated muscle tissues. supplementation of beta-alanine in elderly patients has resulted in an increase in physical activity, less fatigue and overall increase in l-carnosine concentration in muscles. pfmt utilization is considered a strong predictor of early return of urinary continence after radical prostatectomy (rp). we hypothesize, that combination of pfmt with beta-alanine could result in improved urinary continence after rp. the intervention will start 30 days before the surgery and will continue until primary outcome is met. beta-alanine/placebo will be given daily. efficacy, pharmacokinetics, biomarkers, tissue histology, participants reported outcomes and safety will be assessed. the total duration of study will be approximately 6 months.

Eligibility criteria:
* inclusion criteria: * age 40-80 years * able to give informed consent * histologically proven prostate cancer * bmi \<35 * no other cancer treatment * continent * good physical and mental activity * on normal diet * scheduled for radical prostatectomy (open or robotic) * exclusion criteria: * other malignant cancer (except for benign skin cancer) * age \> 80 years * diabetes mellitus (any type) * chronic bowel inflammatory disease * urinary incontinence * impaired mental activity * previous radiotherapy of hormonal therapy * vegetarian/vegan/on macrobiotic diet
the effects of scapulohumeral rehabilitation on scapula kinematics and upper extremity functionality in individuals with parkinson's disease

Conditions: Parkinson&#39;s Disease (PD); Physiotherapy and Rehabilitation

Summary: with this study, individuals diagnosed with pd in burdur province in turkey will be provided with a physiotherapy and rehabilitation program for the upper extremity, and it is thought that the treatment received by both groups will have a positive effect on the functionality of the individuals. according to the results of our study, it will be determined whether the scapula kinematics and upper extremity functionality of individuals diagnosed with pd are different from healthy individuals of the same age and gender. after the intervention programs applied to the individuals, it is thought that it will contribute to the physiotherapy and rehabilitation programs of individuals with pd by determining whether the scapulohumeral rehabilitation program is superior to the upper extremity neurorehabilitation program.


Eligibility criteria:
inclusion criteria: * for the intervention group: * having been diagnosed with parkinson's disease * being between 1-3 according to the hoehn \& yahr staging * for the control group: * being of the same age and gender as the individuals diagnosed with parkinson's disease included in the study exclusion criteria: * for the intervention group: * refusing to participate in the study * having a full-thickness rotator cuff muscle rupture * having a history of humerus, clavicle, scapula or shoulder surgery * having a history of humerus, clavicle, scapula or shoulder fracture * having a history of any other disease that may affect the ability to stand independently * for the control group: * refusing to participate in the study * having a full-thickness rupture of the rotator cuff muscles * having a history of humerus, clavicle, scapula or shoulder surgery * having a history of humerus, clavicle, scapula or shoulder fracture study exclusion criteria for volunteers: * failure to complete the tests included in the study * failure to comply with the study schedule, failure to complete sessions * incomplete data * failure to attend 3 consecutive sessions * voluntary withdrawal

Keywords: parkinson&#39;s disease phsyiotherapy and rehabilitation upper extremity neurorehabilitation scapulahumeral rehabilitation