Kornimate/medical-research-clean huggingface dataset:
the vivaer procedure for treatment of the septal swell bodies (swell)

Conditions: Nasal Obstruction

Summary: post-market study to access the clinical use of the vivaer arc stylus to treat septal swell bodies (ssb).

prospective, open-label, multicenter, single arm study of the aerin medical vivaer arc stylus to treat septal swell bodies (ssb) to improve symptoms in adults diagnosed with nasal obstruction attributed to ssb.

Eligibility criteria:
inclusion criteria: 1. age 22 to 85 years (inclusively). 2. seeking treatment for nasal obstruction and willing to undergo an office-based procedure. 3. baseline nose score ≥ 55. 4. presence of ssb hypertrophy limiting visualization of the middle turbinate (mt) by more than 50%. 5. reduction in size of the ssb after application of topical decongestant on a cotton plug directly to the ssb region. 6. improvement in the symptoms of nasal obstruction after ssb decongestion suggesting that the ssb may play a role in nasal obstruction. 7. willing and able to withhold anticoagulant medications during the perioperative period (3-day window on either side). 8. willing and able to provide informed consent. 9. willing and able to comply with the participant-specific requirements outlined in the study protocol. exclusion criteria: 1. rhinoplasty, septoplasty, inferior turbinate (it) reduction, or other surgical nasal procedures within the preceding 6 months. 2. severe case of any of the following: septal deviation, turbinate hypertrophy, polyps, or ptotic nose tip believed to be the primary contributor to the participant's nasal obstruction symptoms and warranting surgical intervention. 3. any adjunctive surgical nasal procedure planned on the same day or within 3 months after the vivaer procedure. 4. known or suspected allergies or contraindications for any general or local anesthetic agents. 5. known or suspected to be pregnant or is lactating. 6. participating in another clinical research study. 7. other medical conditions which in the opinion of the investigator would predispose the participant to poor wound healing or increased surgical risk, or poor compliance with the requirements of the study. 8. known or suspected regular use of oxymetazoline (afrin) nasal decongestant or oral steroids. 9. for sites participating in the ct substudy only: active sinus condition (eg, significant sinus diseases, infection or polyp formation) identified by ct.
clinical outcomes of sutured versus sutureless conjunctival autograft in primary pterygium excision

Conditions: Pterygium of Conjunctiva and Cornea; Pterygium of Both Eyes; Pterygium

Summary: the goal of this study is to find out if a certain technique in pterygium excision surgery ,using no sutures, is better than the technique mostly used ,which uses sutures. investigators aim to find out whether the no sutures technique provides better efficiency and patient satisfaction than the traditional approach. they predict that if this study provides evidence of the advantages of this technique over the one used, surgeons would be encouraged to use it instead. because not only would the patient benefit, the surgeon also may save operative time and effort used in the technique which uses sutures.

this study is a comparative interventional study, in which patients are assigned into two groups comparable in age, gender, and general condition. the first group consists of patients with primary pterygium who will undergo surgery in a traditional approach in which the pterygium is surgically removed and after which a conjuctival graft is placed on the exposed sclera and sutured to the surrounding conjuctiva; in comparison, patients of the second group undergo pterygium excision in a similar matter initially.but the conjuctival graft is placed on the exposed sclera without suturing it to the nearby conjuctiva; instead, the graft remains in place using the patient's autologous blood. fresh blood is left under the graft, while the surgeon merely compresses the graft for a few minutes. the aim of this study is to reach a conclusion as to which technique is more beneficial, to the patient and surgeon. patients included in this study must have primary pterygium, no known hematological condition, and full consent to the study. surgery time is recorded to compare the effect of avoiding sutures on the surgeon's speed. after that, patients are followed up in documented certain intervals post-operative, to assess graft displacement, signs of inflammation, signs of bleeding under graft, and patients' overall discomfort and satisfaction. finally, the two groups are compared with all factors taken into consideration. the ultimate target is to document evidence of the efficiency of the sutureless technique and endorse its application by ophthalmologists elsewhere.

Eligibility criteria:
inclusion criteria: * adults aged between 18-60 years old. * patients diagnosed with primary pterygium (grades 1-4) exclusion criteria: * patients unable to offer viable consent * patients with other significant ocular surface diseases, bleeding disorders, or systemic conditions affecting wound healing.) * recurrent pterygium * combined ocular surgery

Keywords: pterygium surgery sutureless pterygium autologous blood serum pterygium excision using autologous blood in comparison to using sutures new techniques in pterygium surgery
side effects of bone marrow derived cd133 transplantation in cerebral palsy

Conditions: Cerebral Palsy

Summary: cerebral palsy (cp) is condition, sometimes thought of as a group of disorders that can involve brain and nervous system functions such as movement, learning, hearing, seeing, and thinking.cerebral palsy is caused by injuries or abnormalities of the brain. most of these problems occur as the baby grows in the womb, but they can happen at any time during the first 2 years of life, while the baby's brain is still developing.bone marrow derived stem cells are known as a effective therapy. in this study the investigators evaluate the side effect of bone marrow stem cell transplantation in patients with cerebral palsy.

our study evaluate the side effects of bone marrow derived cd133 cells transplantation in 4-12years old patients with cerebral palsy.first all the patients undergone a comprehensive evaluation(physical exam, serology tests,eeg,mri,gmfm66). after bone marrow aspiration,autologous stem cells prepare for each patient. in operation room ,the cells are transplanted by intrathecal injection. all the patients would be under observed to notice acute side effects and 3,6,9 and 12 months after injection they will be followed and evaluate by comprehensive tests.

Eligibility criteria:
inclusion criteria: 1. a diagnosis of spastic quadriplegic cp 2. children must be between the ages of 4 and 12 years 3. children must be cleared by an orthopedic surgeon for risk of hip subluxation or dislocation and cannot have significant scoliosis (curvature \> 40 degrees) 4. children must be seizure-free or seizure controlled exclusion criteria: 1. children who have a diagnosis of "mixed" types of cp (i.e. athetosis) or other movement disorders (i.e. ataxia) 2. children who have had a selective dorsal rhizotomy, are presently are receiving intrathecal baclofen, or have changed their spasticity medications in the past 6 months. 3. children who have a metallic or electrical implants

Keywords: bone marrow cd133 transplantation side effects side effects
comparison of peep in acute decompensated heart failure

Conditions: Heart Decompensation; Mechanical Ventilation Pressure High

Summary: little is known about optimal level of positive end-expiratory pressure (peep) in patiens who recieved invasive mechanical ventilation for acute decompensated heart failure. we therefore sought to compare clinical outcome according to low versus high peep.


Eligibility criteria:
inclusion criteria: 1. subject who was diagnosed with congestive heart failure and objective evidence of pulmonary congestion (pulmonary edema on simple chest radiography or positive b-line on lung ultrasonography and elevated b-type natriuretic peptide or n-terminal pro-brain natriuretic peptide level) as a reason for invasive mechanical ventilation 2. age over 19 years old 3. subject who agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate institutional review board/ethical committee of the clinical site. exclusion criteria: 1. subject who are on mechanical circulatory support (ecmo, intra-aortic balloon pump, vad) at the time of randomization 2. subject who has cardiac abnormality that requires emergent or urgent percutaneous or surgical valvular procedure 3. subject who are on vasoactive or inotropic agents at least moderate dose defined as vasoactive-inotropic score \>10 4. isolated preload-dependent cardiac dysfunction (isolated right ventricular failure, right ventricular infarction, constrictive pericarditis, cardiac tamponade, severe pulmonary hypertension without lv dysfunction) 5. predominant right ventricular failure defined as following; clinical evidence of right ventricular failure by attending physician's discretion including hepatojugular reflux, kussmaul sign, cardiac liver cirrhosis, hepato/splenomegaly, acites, thronmbocytopenia, etc. 6. subject who are not on mechanical ventilation before open heart surgery 7. subject who received unwitness cardiopulmonary rescucitation (cpr) or witness cpr lasting more than 30 minutes 8. subject who was already diagnosed or is suspected to have hypertophic cardiomyopathy with significant left ventricular outflow tract (lvot) obstruction 9. subject with intracranial hemorrahge or ischemic stroke at the time of randomization 10. subject with irreversible neurologic damage or irreversible hepatic failure 11. invasive mechanical ventilation lasting more than 24 hours preceding endotracheal intubation 12. subject with underlying chronic obstructive pulmonary disease (gold classification iii or iv) or restrictive pulmonary disease (e.g. interstitial lung disease) 13. subject with impaired consciousness that can not perform self coughing and need suction to maintain adequate airway patency 14. pregnant and/or lactating women 15. subject with life expectancy less than a year 16. subject who is not suitable to enrollment by investigator's discretion
systematic review and meta-analysis of cereal or grain consumption and gastric cancer

Conditions: Gastric Cancer

Summary: this project involved a systematic literature review of published trials of cereal or grain in relation to the risk of gastric cancer. data was extracted from the publications on pubmed, embase, cochrane library.a traditional meta-analysis, subgroup analysis, and heterogeneity was conducted on the extracted data.

investigators searched pubmed, embase, cochrane library for studies focusing on cereal or grain in relation to the risk of gastric cancer up to october 2017. summary odd ratios (or) and 95% confidence intervals (ci) were calculated by using either random effect models or fixed effect models according to the heterogeneity of included studies. subgroup analysis, heterogeneity, and publication bias were also performed.

Eligibility criteria:
inclusion criteria: * a case-control studies or a cohort study * investigate the association between cereal or grain intake and gc occurrence * report an odds ratio (or) or relative risk (rr) with corresponding 95% confidence intervals (ci) * provide sufficient data to estimate or or rr exclusion criteria: * non-human studies * gc mortality-based cohort studies

Keywords: cereal whole grain refined grain gastric cancer meta analysis
comparing perioperative education modalities for acl reconstruction on patient satisfaction, self-efficacy, and surgical outcomes

Conditions: ACL Injury; Anterior Cruciate Ligament Injuries

Summary: the purpose of this research is to find out whether the way information about surgery is presented to patients affects patient satisfaction, knowledge retention, and surgical outcomes such as anxiety


Eligibility criteria:
inclusion criteria: * patients of senior attending orthopedic sports medicine surgeons at mayo clinic arizona * patients with a proficiency in english in order to participate without need for translator. * patients with a diagnosis of a primary acl injury in need of surgical reconstruction utilizing any surgical technique for acl reconstruction. exclusion criteria: * patients with a diagnosis of acl injury in need of a surgical revision. * patients who have any multi-ligamentous injuries to the knee requiring modified postoperative unloading. * patients who have history of previous anterior cruciate ligament reconstructions in either leg. * patients who have either auditory or visual impairments. * patients who are medical professionals with work-related knowledge of acl reconstruction. * patients with an inability or unwillingness of individual or legal guardian to give written informed consent.

Keywords: acl reconstruction
the efficacy of the iurisure for detection of recurrent urothelial carcinoma

Conditions: Urothelial Carcinoma

Summary: the clinical trial was designed to determine the efficacy (sensitivity and specificity) of the iurisure test compared to the gold standard cystoscopy and pathology in patients under monitoring for recurrence of urothelial carcinoma.


Eligibility criteria:
inclusion criteria: 1. patients with high suspicion/confirmed urothelial carcinoma by ct, ctu, mr and other imaging examinations and meet the indications for surgery, including turbt, partial cystectomy, radical nephroperectomy and kidney-sparing surgery; 2. patients with highly suspected/confirmed recurrence of urothelial carcinoma who meet the indications for surgery, including turbt, partial cystectomy, radical nephroperectomy and kidney-sparing surgery; 3. the patient agrees to participate in this study and has signed the informed consent form. exclusion criteria: * (1) patients with urothelial carcinoma combined with other malignant tumors; (2) patients with a history of other non-urothelial carcinoma cancers; (3) samples that are not urothelial carcinoma in surgical pathology; (4) samples of ta/low-grade urothelial carcinoma shown by surgical pathology.

Keywords: bladder cancer upper tract urothelial carcinomas recurrence methylation
social media and covid-19

Conditions: Coronavirus; Depression; Anxiety; Stress

Summary: in this protocol, we seek to examine the role of popular messaging platform whatsapp in information spread during a crisis. as there have been few global crises in the last decade (coinciding with the rise of social media), the role of private messaging platforms such as whatsapp during crisis contexts remains understudied. during the current covid-19 global health crisis, we undertook this study to: (1) characterize the nature of whatsapp use during crises, (2) characterize the profiles of whatsapp users (3) understand how whatsapp usage links to well-being (fear and thoughts about covid-19).


Eligibility criteria:
inclusion criteria: * at least 21 years * has stayed in singapore for at least 2 years * has a whatsapp account that can be used for the research study exclusion criteria: * below 21 years * has stayed in singapore for less than 2 years * does not have a whatsapp account that can be used for the research study

Keywords: social media misinformation covid-19
glenohumeral internal rotation deficit in non-pitcher overhead athletic athletes: case series analysis of athletes

Conditions: Shoulder Injuries; Shoulder Syndrome; Injury;Sports; Sport Injury

Summary: in this observational case series the investigators would like to investigate wether or not the strenuous activity exerted on over head athletic athletes (ie. javelin throwers, discus throwers) may incite injury on their shoulders. the investigators understood that these athletes had to perform repeated throwing motions and yet reports on their effects are very limited. this condition in the long run may contribute to injury and affecting performance of the athletes. the investigators found that these relationships have not been looked at closely by others and largely overshadowed by athletes in other fields; such injury patterns had been described in details in baseball pitchers but not in other athletes.

description of protocol: in this study, the investigators would recruit athletes from the national athletics federation training in our city. data collection: history taking: * complaints of shoulder stiffness * need for prolonged warm-up * pain * discomfort relating to the shoulders physical examination: * bilateral shoulder range of motion (internal and external rotation) * posterior shoulder flexibility test (denotes internal rotation deficit) * scapular malpositioning, inferior medial border prominence, coracoid pain and malposition and dyskinesis of scapular movement (sick) scapula rating notes: measurements are taken by at least two investigators separately and compared to ensure accuracy. results are presented in a table and analysed.

Eligibility criteria:
inclusion criteria: * performed overhead throwing motions in their athletic skills * athletes have competed in regional and national level * undergoing active training exclusion criteria: * apparent anatomical deformity * sustaining injury(ies)

Keywords: shoulder glenohumeral internal rotation deficit throwing athletic athlete
substrate metabolism, growth hormone signaling (gh), and insulin sensitivity during gh and ketone bodies infusion

Conditions: Healthy

Summary: background: humans naturally produce ketone bodies under daily living conditions. the main ketone bodies are two functioning acids, beta-hydroxybutyric acid (3-ohb) and acetoacetate, and the ph-neutral, but odorous, acetone. in the fed state, level of 3-ohb is suppressed to an almost unmeasurable level while, in the fasted state, it rises to 0.1-0.5 millimoles (mm). main regulation of ketone synthesis is the abundance of sugars and resulting adaptations in insulin secretion. thus, ketone bodies are formed when sugar is not readily available and insulin is suppressed. this picture is, to a certain degree, seen in acute inflammatory states and, indeed, during starvation, where level of 3-ohb increases to 5-8 mm. hypothesis: 1. ketone bodies changes the insulin sensitivity and substrate metabolism in human subjects 2. ketone bodies changes the gh signaling in muscle and adipose tissue aim: the investigators wish to provide knowledge on changes in metabolites and shift in signaling pathways and insulin sensitivity during gh infusion and concomitant ketone bodies infusion among healthy subjects.


Eligibility criteria:
inclusion criteria: * healthy men * written consent * body mass index (bmi) 18.5 - 25 * age 20-50 years exclusion criteria: * any kind of disease * regular medication
survey study for pain management, wound care, scar care or udt

Conditions: Pain; Scars; Wounds; Urinary Drug Testing

Summary: this is a survey study that will be given to patients who have been prescribed a topical compound for pain management, wound care or scar care or to patients who have been requested to do a urinary drug test (udt) by their provider. the initial survey for pain management, wound care, scar care or udt will be given to the patient by their providers during their office visit.

we have designed a survey study that will be given to patients who have been prescribed a topical compound for pain management, wound care or scar care or to patients who have been requested to do a urinary drug test (udt) by their provider. the initial survey for pain management, wound care, scar care or udt will be given to the patient by their providers during their office visit. follow-up surveys will be given at 30, 60, and 90 days. these surveys will be collected by e-mail or follow-up calls from datum research, llc, contract research organization. data collection for this study will be derived through the 4 patient surveys (initial, 30 day, 60 day, and 90 day) and the prescription written by the provider. the survey study will enroll patients until december 31, 2014, or until sufficient numbers have been achieved. rahm foundation will continue the study until: * sufficient information has accumulated to meet the scientific objectives of the study (i.e. numeric targets or effect size) * the feasibility of collecting sufficient information diminishes to unacceptable levels, poor enrollment, loss to follow-up and/or * other methods of gathering appropriate information become achievable or are deemed preferable. datum research will need to have access to the prescription to see what compound was prescribed.

Eligibility criteria:
inclusion criteria: * prescribed a topical cream for pain, scar care, or wound or provider preforms urinary drug test exclusion criteria: * subjects with legally authorized representatives * minors * prisoners

Keywords: pain management scar care wound care udt urinary drug testing
variability in transcranial doppler technique in neuro-critical care patients

Conditions: Cerebral Aneurysm; Stroke; Vasospasm, Cerebral; Subarachnoid Hemorrhage, Aneurysmal; Aneurysmal Subarachnoid Hemorrhage; Cerebral Ischemia

Summary: this study aims to determine the inter- and intra-variability of transcranial doppler (tcd) ultrasound in neuro-critical care patients who are planned for consecutive daily tcd evaluations.

patients enrolled in the study are recruited from the pool of neuro-critical care patients admitted to the surgical intensive care unit (sicu). when the patients are admitted in the surgical icu, the study staff will determine eligibility based on the protocol inclusion criteria. due to the nature of the disease, there is a high likelihood that patients are either unconscious, of limited mental capacity and/or have been intubated therefore when appropriate the legally authorized representative will be utilized to obtain research consent. to meet study inclusion, transcranial doppler (tcd) testing will be ordered as part of the standard of care for these patients. the test will not be ordered solely for research purposes. there are no known side effects from the non-invasive measurement of cerebral blood flow using ultrasound three different tcd technicians will do triplicate readings on 3 consecutive days on up to 12 patients already undergoing tcd as ordered by their treating team. standard of care on specific neuro critical care patients (such as cerebral aneurysms) is to undergo daily tcd monitoring to assess for possible vasospasm. patients will be in the supine position while measurements are obtained. the probe will be placed in the preauricular region of the temporal window

Eligibility criteria:
inclusion criteria: 1. adults 18 years of age or older 2. current hospitalization for a neurologic issue and admitted to the surgical intensive care unit. 3. undergoing daily transcranial doppler imaging no 4. english speaking patients and/or legally authorized representative (lar) exclusion criteria: 1. less than 18 years of age 2. patient is unable to obtain consent and no lar is identified to provide consent 3. non-english speaking patient or lar 4. unable to perform the study due to lack of availability of tcd technologists

Keywords: transcranial doppler tcd interrater variability intrarater variability transcranial doppler ultrasound neurocritical care dci delayed cerebral ischemia mca pca mean flow velocity