Kornimate/medical-research-clean huggingface dataset:
understanding the relationship between inflammation and insulin resistance in the adipose tissue

Conditions: Obesity; Insulin Resistance

Summary: this study is being done to better understand the relationship between inflammation and insulin resistance in your adipose (fat) tissue .

this study is being done to determine whether eosinophils (a type of white blood cell) play an important role in human fat metabolism and inflammation. this study is being done to determine if fish oil supplement could play a role in reducing inflammation and improving insulin sensitivity in your fat tissue.

Eligibility criteria:
lean, healthy person with a body mass index (bmi) of 25 or less, or you are obese, bmi between 30 and 50, and non-diabetic. lean healthy controls will not be on any medication and will be undergoing elective abdominal surgery excluding those involving acute inflammation (i.e. acute cholecystitis, bowel perforation, or diverticulitis). obese, non-diabetic subjects will have a bmi between 30 and 50 and be taking no medications affecting glucose metabolism or lipid metabolism. these subjects will be identified from a pool of patients undergoing an elective abdominal surgical procedure such as inguinal hernia repair, laparoscopic nissen fundoplication, planned cholecystectomy, but also bariatric surgery. volunteers will not be taking corticosteroid therapy or have a history of asthma, copd or atopic syndrome. all subjects will undergo a medical history intake and a physical examination followed by an ogtt to confirm normal glucose.

Keywords: obesity insulin resistance
effect of early removal of wound drains after mastectomy or lymph node dissection

Conditions: Draining Wound; Breast Cancer

Summary: to compare early drain removal versus output-based drain removal, assessing the following end-points: clinical : risk of seroma and infection, woundhealing, duration of wound care and drain output versus volume of seroma. quality of life : drain-induced pain, discomfort due to seroma or drain, sleep disturbance and implications on daily activities. cost-effectiveness


Eligibility criteria:
inclusion criteria: * patient scheduled for breast cancer surgery with placement of suction drainage * female or male * age \> 18 years * all stages of disease (inclusion is independent of tnm-classification) exclusion criteria: * patients scheduled for breast cancer surgery without placement of suction drains * no informed consent: patient refuses participation or is not able to give a written informed consent
trajectories of recovery after intravenous propofol versus inhaled volatile anesthesia trial

Conditions: Surgery-Complications; Anesthesia Complication; Anesthesia Awareness; Anesthesia; Surgery; Quality of Life; Pain, Postoperative; Anesthesia Morbidity

Summary: the investigators will conduct a 12,500-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether tiva confers no more than a small (0.2 %) increased risk of intraoperative awareness than inva in patients undergoing both outpatient and inpatient surgeries


Eligibility criteria:
inclusion criteria each patient must meet all of the following criteria: 1. aged 18 years or older 2. undergoing elective non-cardiac surgery expected to last ≥ 60 min requiring general anesthesia with a tracheal tube or laryngeal mask airway (or similar supra-glottic device) exclusion criteria patients will not be enrolled if any of the following criteria are met: 1. inability to provide informed consent in english (at all study sites) or spanish (at sites where spanish consent is provided as an option) 2. pregnancy (based on patient report or positive test on the day of surgery) 3. surgical procedure requiring general, regional, neuraxial anesthesia administered by an anesthesia clinician (anesthesiologist, crna, anesthesiology assistant) occurring within 30 days prior to or planned to occur within 30 days after surgery date 4. contraindication to propofol tiva or inva (for example, documented allergy to propofol, history of severe postoperative nausea or vomiting, concern for or history of malignant hyperthermia) based on self-report 5. surgical procedures requiring a specific general anesthesia technique (for example, tiva required for neuromonitoring). 6. locally approved, written protocol mandating a particular anesthetic technique 7. history of possible or definite intraoperative awareness during general anesthesia based on patient self-report 8. planned postoperative intubation 9. current incarceration
a study of a low-carbohydrate diet to improve maternal health after childbirth

Conditions: Obesity; Postpartum Weight Retention; Insulin Sensitivity

Summary: the study is evaluating the effects of a standard diet to a low carbohydrate diet in obese women after having a baby. the purpose of the study is to determine if a low carbohydrate diet is associated with improvement in insulin sensitivity in postpartum women.


Eligibility criteria:
inclusion criteria: * delivery at university of texas medical branch * body max index greater than or equal to 30 kilograms/meters squared at the final prenatal visit prior to delivery. * singleton gestation. * accessibility to the internet. * basic understanding and comprehension of the english language to be assessed by study personnel at the time of recruitment. exclusion criteria: * diabetes mellitus on medication. * serious medical condition, such as heart failure, kidney failure, or severe asthma, as determined by the principle investigator. * planned pregnancy during study period. * enrolled in another trial that may affect outcome. * subject unlikely to be followed up after delivery.

Keywords: low carbohydrate diet
unwanted penile engorgement in pediatric patients under anesthesia.

Conditions: Anesthesia; Functional

Summary: penile engorgement during intraoperative period is of rare occurrence however when do happens, leads to difficulty in performing and even cancellation of elective urogenital surgery. the mechanism behind intraoperative penile engorgement is complex and involves various factors. one common myth is that penile engorgement occurs only during spinal anaesthesia and not in general anaesthesia. in this study we intend to report the incidence and management of intraoperative penile engorgement in pediatric patients undergoing urogenital operations under spinal anesthesia with/without sedation over a period of one year. the pathophysiology and role of common contributing factors leading to intraoperative penile engorgement are also discussed.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologist grade1 \& 2 * elective urogenital surgery of expected duration less than one hour exclusion criteria: * patients with local infection, coagulation abnormalities, expected duration of surgery \>1 hour and spinal anomalies. * parents of patient not giving consent for spinal anaesthesia.

Keywords: intraoperative penile engorgement anaesthesia urogenital surgery
autonomic evaluation of patients with hereditary amyloidotic cardiomyopathy: hereditary amyloidotic heart disease

Conditions: Autonomic Nervous System Disease; Amyloid Neuropathies

Summary: transthyretin amyloidosis exhibits a variety of possible phenotypes, the hereditary neurological form being the most commonly found and studied (familial amyloidotic polyneuropathy or fap), which can present from oligosymptomatic patients to patients with peripheral sensorimotor polyneuropathy of varying degrees and dysautonomia. although a specific mutation usually causes a specific phenotype, that is, with a predominantly cardiac or preferential neurological profile, with the increase in the number of diagnosed cases, an overlapping of clinical presentations has been observed. the assessment of the autonomic profile in individuals with familial amyloidotic cardiomyopathy (fac) has not been well studied, and it is not known whether patients with an exclusively cardiac profile of the disease may present dysautonomia or whether even mutation carriers without cardiac involvement may exhibit it. in this study, the autonomic profiles of patients with familial amyloidotic heart disease will be compared with the profiles of patients who have mutations but without established heart disease and healthy individuals (control group).


Eligibility criteria:
inclusion criteria: * fac group: patients with familial familial amyloidotic cardiomyopathy (fac). * non-fac group: patients with transthyretin gene mutations who do not have fac. * control group: healthy, asymptomatic individuals without comorbidities and without transthyretin gene mutations. * agreement and signing the informed consent form. exclusion criteria: -
saline sonohystrography and office hysteroscopy in evaluation of cases of abnormal uterine bleeding

Conditions: Gynecologic Disease

Summary: comparing the efficacy of the 3d saline infusion sonohysterography to the diagnostic office hysteroscopy in the diagnosis of the cause of abnormal uterine bleeding in females during their reproductive age


Eligibility criteria:
inclusion criteria: * female aged between 20 and 45 years * with no medical disorders * approving to participate in the study exclusion criteria: * vaginal or cervical lesions * history or suspicion of pid * iud users * bleeding disorders * on anticoagulant therapy * irregular use of oral contraceptive pills
risk factors of postoperative complications and survival rate in pancreatic ductal adenocarcinoma patients

Conditions: Pancreatic Cancer

Summary: by evaluating the nutritional status of patients with pancreatic ductal adenocarcinoma (pdac) admitted to jinling hospital, collecting relevant clinical data. we aim to conduct correlation analysis with patient clinical information, such as survival time, hospitalization time, nutritional status, hematological indicators, etc., in order to reveal the prognostic factors for overall survival and postoperative complications of pdac patients.

personalized and accurate survival risk prognostication remains a significant challenge in pancreatic ductal adenocarcinoma (pdac), despite extensive research on prognostic and predictive markers. patients with pdac are prone to muscle loss, fat consumption, and malnutrition, which is associated with inferior outcomes. this study investigated the use of three-dimensional (3d) anthropometric parameters derived from computed tomography (ct) scans and hematological indicators in relation to overall survival (os) outcomes and postoperative complications in pdac patients. a retrospective analysis was conducted on patients with pdac, all of whom had undergone pretreatment abdomen-pelvis ct scans. automatic 3d measurements of subcutaneous and visceral fat volume, skeletal muscle volume, and skeletal muscle density (smd) were assessed at the l3 vertebral level by an artificial intelligence assisted diagnosis system (hy medical). various indicators including tyg-bmi, nutritional indicators \[geriatric nutritional risk index (gnri) and prealbumin\], and inflammation indicators \[(c-reactive protein (crp) and neutrophil to lymphocyte ratio (nlr)\] were also recorded.

Eligibility criteria:
inclusion criteria: * all eligible patients diagnosed with pdac exclusion criteria: * 1) suffering from chronic or acute diseases related to malnutrition: chronic heart failure, cirrhosis, chronic kidney disease and infection, cognitive impairment, dysphagia or gastrointestinal obstruction, etc; 2) using excessive doses of systemic glucocorticoids within 4 weeks prior to enrollment;

Keywords: pancreatic cancer risk factors postoperative complications overall survival
real word european registry of ntrk fusions and other rare actionable fusions (tracking)

Conditions: Cancer; Cancer Metastatic; NTRK Gene Fusion Overexpression; NTRK Family Gene Mutation; ATIC-ALK Fusion Protein Expression; ALK Fusion Protein Expression; BCR-FGFR1 Fusion Protein Expression; ROS1 Gene Translocation; COL1A1-PDGFB Fusion Protein Expression; RET Gene Translocation; Gene Fusion; ROS Gene Translocation; BRAF Gene Rearrangement; FGFR2 Gene Translocation; FGFR3 Gene Translocation; NTRK1 Gene Translocation

Summary: this registry will make it possible to describe real life management of patients with rare actionable fusions and to better understand these cancers. in addition of clinical data from the medical files, a quality of life questionnaire (qlq-c30) will be complete at inclusion, at each new treatment and then every 6 months. the patients will be followed for a period of at least 2 years after the inclusion. this tracking registry is a european collaborative tool to improve the management of patients with actionable fusions, by sharing of data from rare tumor indications.

1. administrative opening of the center 2. routine identification of a patients harboring a rare actionable fusion 3. patient's inclusion * signature of written informed consent, * declaration by the physician to the coordinating center (using the "physician declaration" form) * completion of the qlq-c30 questionnaire (at inclusion, at each new treatment and then every 6 months). 4. collection of retrospective and prospective data into the e-crf by a local cra using patients' medical files.

Eligibility criteria:
inclusion criteria: * patient with histologically-confirmed cancer * patient harboring a rare actionable fusion (see appendix 1), * availability of clinical and demographic data, information on treatment and clinical outcome. * adult, ≥18 years old, * patient should understand, sign and date the written voluntary informed consent form. exclusion criteria: -

Keywords: actionnable fusion cancer registry european reference network
evaluation of labor related pelvic floor changes: a 3d transperineal ultrasound study

Conditions: Pelvic Floor Disorders

Summary: the aim of the study was the define changes lam morphology, biometric measurements of the lam and genital hiatus at immediate evaluation of pelvic floor and at 3 month after delivery was evaluated. we also sought to define the optimal time for evaluation of pelvic floor after childbirth

sixty four of 72 primiparous women who vaginally delivered singleton babies that eligible for trial were examined within 36 h of delivery and at 3rd months after delivery.parameters such as age, episiotomy, mode of delivery, duration of labor, birthweight and antenatal biparietal diameter (bpd) measures were obtained from the clinical files. the length of the first stage of labor was calculated from the beginning of regular and at least three strong uterine contractions in 30 min according to the women's statements, tocography and palpations to full dilatation. all static ultrasound volume acquisitions were performed by the same experienced sonographer trained in pelvic floor ultrasound within 36 h of delivery. same patients invited for second evaluation.two 3-d volumes (one at rest, one on valsalva maneuver) were recorded in the supine position after voiding.the effectiveness of valsalva was ascertained by observing 2-d ultrasounds before acquiring volumes.. lam thickness is determined at the plane of minimal hiatal dimensions rather than 1-1.5 cm above the actual lam hiatus where lam thickness is maximal as described by dietz et al.(15). the following parameters were assessed for this study: maximum diameters of the lam hiatus (anteroposterior and transverse) at rest and on valsalva maneuver; area of the lam hiatus at rest and on valsalva; and pubovisceral muscle thickness (left and right of the rectum), difference in anteroposterior and transverse diameter of hiatus and lam hiatus area between rest and valsalva

Eligibility criteria:
inclusion criteria: * primiparous women who vaginally delivered singleton babies that eligible for trial were examined within 36 h of delivery exclusion criteria: * operative deliveries (forceps or vacuum assisted), multifetal pregnancy, cesarean delivery, handicap in lithotomy position, refused consent and uncooperative patient for effective valsalva maneuver.

Keywords: levator avulsion transperineal ultrasound levator hiatus
turbt with adjuvant cryoablation to treat bladder cancer

Conditions: Urinary Bladder Neoplasms

Summary: the purpose of this study is to evaluate the safety and efficacy of applying cryoablation as an adjuvant therapy with tur to treat bladder tumor.

bladder tumors are one of the most commonly diagnosed urinary tumors in the world. worldwide, it has been estimated that 429,800 new cases of and 165,100 deaths due to bladder tumor occurred in 2012. transurethral resection (tur) is the gold-standard treatment for non-muscle invasive bladder cancer (nmibc). in muscle-invasive bladder cancer, tur also plays a vital role as a bladder-sparing procedure regardless of whether it is applied as a monotherapy or in combination with chemo-radiotherapy. whether radical resection of a tumor is initially performed can be essential in the treatment of bladder tumors. incomplete tur influences a patient's prognosis, regardless of whether it is part of a nmibc treatment or part of bladder-sparing trimodal therapy. however, the quality of tur is one of the greatest concerns in the treatment of bladder tumor. after initial tur, approximately 70% of patients exhibit incomplete resection re-staging tur. of these patients, 30% exhibit residual tumors at the resection site. to solve this problem, a second tur 4-6 weeks after the initial tur is recommended by the guidelines, and these repeated turs detect residual tumors in 26-83% of cases. the investigators sought to identify other therapies that can be combined with tur to eliminate residual tumors. as a minimally invasive method, cryotherapy has been widely used for urological tumors, including prostate tumor and kidney tumor. with respect to bladder tumors, cryotherapy remains in the exploration phase. only a few studies of the use of computed tomography (ct)-guided percutaneous cryoablation for the treatment of bladder cancer have been reported. unlike solid viscera, such as the prostate or kidney, the bladder exhibits the features of hollow viscera. cryoablation through the transurethral approach could be possible if the safety of the procedure can be ensured. our recent animal study conducted in a porcine model demonstrated the feasibility and safety of transurethral focal, full-thickness cryoablation. no perforations were observed during two eight-minute freeze cycles. based on the success of transurethral cryoablation in animal experiments, the investigators performed this study to explore the safety and efficacy of cryoablation as an adjuvant therapy with tur in the treatment of bladder tumors.

Eligibility criteria:
inclusion criteria: * clinically diagnosed bladder tumor, stage t1 or t2 * number of lesions ≤ 3 * tumor size ≤ 3cm exclusion criteria: * with other malignant diseases * t3 or above * enlarged pelvic lymph node or distant metastasis * poor overall condition

Keywords: bladder cancer cryoablation
antiarrhythmic therapy versus catheter ablation for atrial fibrillation in hypertrophic cardiomyopathy

Conditions: Atrial Fibrillation; Hypertrophic Cardiomyopathy

Summary: paroxysmal or chronic atrial fibrillation (af) develops in about 20- 25% of adult patients with hypertrophic cardiomyopathy (hcm) and represents an important complication in the clinical course of the disease, with adverse long-term consequences on functional status and outcome. therefore, aggressive therapeutic strategies are indicated to restore and maintain sinus rhythm (sr) in patients with hcm. nevertheless, pharmacologic prevention of af recurrence is challenging because of the limited long-term efficacy and potentially hazardous side effects of available treatment options. currently radiofrequency catheter ablation (rfca) of af is successfully used in clinical practice. however, comparison of the efficacy and safety of these two therapeutic options has not been done up till now in randomized manner in this group of patients. thus, the aim of the present study is to compare the efficacy and safety of rfca vs. antiarrhythmic drug therapy in patients with hcm and af.


Eligibility criteria:
inclusion criteria: * patients with hypertrophic cardiomyopathy and paroxysmal or chronic atrial fibrillation exclusion criteria: * severe hear failure (nyha iv) * left ventricular ejection fraction \<0.30 * left atrial diameter \>65 mm * age \> 70 years * contraindication to anticoagulation with warfarin * presence of a mechanical prosthetic valve * presence of left atrial thrombus on tee or ct * woman currently pregnant * renal failure (gfr \< 30 ml/min) * hepatic failure * untreated hypothyroidism or hyperthyroidism * lvot gradient \> 50 mmhg

Keywords: atrial fibrillation hypertrophic cardiomyopathy rf ablation antiarrhythmic drugs
the long-term effect of tianqi capsule interventions to prevent diabetes in the reduces study: a 8-year follow-up study

Conditions: Impaired Glucose Tolerance; Type 2 Diabetes Mellitus

Summary: objectives: this study is aimed to assess whether tianqi capsule interventions have a long-term effect on the risk of diabetes and provide evidence that early intervention by traditional chinese medicine could delay the progression from impaired glucose tolerance to diabetes. study contents: 1.420 participants were followed up for 8 years to assess the long-term effect of tianqi capsule. phone-call followed up was applied to investigate the status of impaired glucose tolerance and orthoglycemic survivors until the end of reduces study. 2.to participants that determined the status of glucose metabolism, a variety of ways were used to find the evidence of diagnosis of glucose metabolic status, such as glycemia laboratory sheets from normal hospitals, medical records, the use of antidiabetic drugs or insulin injection, etc. 3. to participants that undiagnosed the status of glucose metabolism, oral glucose tolerance test, blood pressure, weight and blood biochemical analysis were performed to assess the state of glucose metabolism. 4. questionnaires were given to all the participants to investigate their condition of treatment, diet, exercise and other lifestyle.

study design: perspective study study drug: tianqi capsuleinclusion criteria: 1. subjects have participated in the reduces study before; 2. informed consent forms were needed to participants performed to blood test; 3. laboratory sheets could be voluntary acquirement by participants that determined the status of glucose metabolism; 4.subjects were not disabled, and could take care of themselves. 5. subjects did not suffer the infectious disease. exclusion criteria: 1. subjects did not participate the reduces study; 2. subjects suffered serious mental illness; 3. subjects suffered severe mental or cognitive impairment; 4. subjects had a history of drug or alcohol dependence; 5. subjects have participated in other drug clinical trials in the past 1 month. main outcome index: incidence of diabetes. secondary outcome index: body mass index, fasting blood-glucose, postprandial blood sugar, blood lipids, blood pressure.

Eligibility criteria:
inclusion criteria: * subjects have participated in the reduces study before; * informed consent forms were needed to participants performed to blood test; * laboratory sheets could be voluntary acquirement by participants that determined the status of glucose metabolism; * subjects were not disabled, and could take care of themselves. 5. subjects did not suffer the infectious disease. exclusion criteria: * subjects did not participate the reduces study; * subjects suffered serious mental illness; * subjects suffered severe mental or cognitive impairment; * subjects had a history of drug or alcohol dependence; * subjects have participated in other drug clinical trials in the past 1 month.