Kornimate/medical-research-clean huggingface dataset:
kyphotic measure using distance from the wall

Conditions: Kyphosis

Summary: are the kypdist and conventional c7wd are practical, valid, reliable, and effectiveness of the tools to discriminate the functional ability impairments relating to kyphosis when compare with gold standard (cobb's method), and compare among physical therapy, vhs and caregiver?

1. to further develop an innovation to measure kyphosis using distance from the wall, a kyphosis wall distance tool (kypdist). 2. investigate validity of the measurements in terms of 2.1 concurrent validity of conventional c7wd and kypdist as compared to a gold standard (cobb's method). 2.2 discriminative ability of conventional c7wd and kypdist on functional abilities in elderly with different severity of kyphosis. 3. to investigate the reliability of the measurements in terms of 3.1 test-retest reliability of conventional c7wd and kypdist. 3.2 reliability of conventional c7wd and kypdist comparing among physical therapy, vhs and caregiver. 4. to explore the distance to indicate risk of spinal fracture to indicate a risk of spinal fracture.

Eligibility criteria:
inclusion criteria: * community-dwelling elderly with different degrees of kyphosis, * aged at least 60 years * body mass index between 18.5-29.9 kg/m2 * owd \>0 cm. exclusion criteria: * present signs and symptoms that may affect participation in the study, i.e. unstable medical condition, pain or inflammation in the joints of the lower extremity (pain scale \> 5), having sequelae of neurological deficits * unable to understand and follow a simple command used in the study.

Keywords: kyphosis kyphosis wall distance elderly
local pharmacokinetics of azithromycin eye drops in healthy volunteers

Conditions: Bacterial Conjunctivitis

Summary: to compare the pharmacokinetic behavior of azithromycin eye drops in the tear with the original azithromycin eye drops, and evaluate the release behavior of both in the eye.

there are 48 patients will divided into group a and group b randomly . subjects of group a will given the first test drug, elution after the control drug; subjects of group b will given the first control drug, elution given to the test drug.

Eligibility criteria:
inclusion criteria: * 18 to 65 years old, male or female; * bmi in the range of 19 to 28; * eyes corrected visual acuity should be ≥ 1.0, intraocular pressure, slit lamp and fundus examination were normal, tear secretion function is normal; * good compliance and voluntarily signed consent. exclusion criteria: * have eye disease or systemic disease; * physical examination, laboratory tests, ecg and chest x-ray examination abnormalities and has clinical significance; * hbsag, anti-hcv and hiv positive; * those who used eye drops two weeks before the test and who used any dosage form of azithromycin; * known to azithromycin or macrolide-related varieties of allergies or serious adverse reactions; * need to wear contact lenses during the test; * history of internal surgery or laser surgery history; * participated in other drug clinical trials in the past three months; * pregnant women and lactating women, or in the growth period without taking effective contraceptive measures, menstrual period women; * mental illness or alcohol, history of drug abuse or inability to collaborate; * any other circumstances that the investigators consider are unfit to participate in this study.

Keywords: azithromycin eye drops local pharmacokinetics
evaluation of positioning protocols on a wheelchair in hemiplegic patients

Conditions: Hemiplegia And/or Hemiparesis Following Stroke

Summary: the main purpose of this study is to assess the interest of using wheelchair positioning equipment on the decrease of postural disorders, compared to the standard use of a wheelchair

the stroke is the main cause of hemiplegia in developed countries. fifteen percent of people who say they have a stroke need, at home, a wheelchair to get from one room to another. the use of a wheelchair can cause postural disorders which can lead to pain, orthopedic deformity and pressure ulcers. this study aims to assess the interest of using wheelchair positioning equipment (seat back, positioning cushion and belt) on the decrease of postural disorders. this decrease will be assessed after a standardized course, performed under three different conditions: with the positioning equipment (positioning cushion and seat back), with the positioning equipment and the belt and with the wheelchair alone. clinical tool used to assess the decrease is the seated postural control measure for adults 2.0 (spcma 2.0). this study, which will be the first prospective, interventional, multicenter, controlled and randomized study, could pave the way for guidelines of good practice, for wheelchair positioning of hemiplegic patients in france

Eligibility criteria:
inclusion criteria: * hemiplegic patient following a stroke * hospitalized in a follow-up and rehabilitative care service, after hospital stays in a mco service (neurology, neurosurgery or reanimation) * with a planned exit from hospital (homecoming, residential care facilities, nursing home, long term care unit ...) * patient whose wheelchair choice should be already done * patient who propels the wheelchair with the valid hand and/or valid foot * written informed consent (ic) obtained * patients with affiliation to the social security system exclusion criteria: * good walk recovery (fac scale \>3) * wheelchair with a double hand rim * patient who cannot use his2 wheelchair independently * cognitive disorders which prevent the ability to well understanding the instructions * other pathology which can interfere with this protocol (spinal disorder, morbid overweight (bmi\>40...)

Keywords: hemiplegia stroke wheelchair positioning propulsion pelvic posterior tilt obliquity
sexual health and rehabilitation after ovarian suppression treatment

Conditions: Breast Cancer Survivors; Sexual Function Disturbances; Ovarian Suppression Treatment

Summary: this research study is evaluating an educational intervention for breast cancer survivors who have experienced changes in sexual function after ovarian suppression treatment to reduce the risk of breast cancer recurrence.

the purpose of this research is to study the effectiveness of an educational intervention for breast cancer survivors who have experienced changes in sexual function after ovarian suppression treatment to reduce the risk of cancer recurrence. the aim is to develop an effective intervention to help women manage these changes and restore sexual health and functioning. - this study consists of attending a group educational session followed by a one-on-one telephone coaching session. * the group educational session will last about 4 hours, and will include information on resources, self-help strategies, and relaxation techniques. * the telephone coaching session will take place four weeks after the group session, and will last about 15 minutes

Eligibility criteria:
inclusion criteria: * women with a history of breast cancer who are currently on chemical ovarian suppression * current age ≤ 50 * no active cancer therapy in the past 6 months and no future therapy planned * endorsement of at least one sexual symptom (see appendix a for eligibility screening) * english-speaking exclusion criteria: * history of pelvic radiation * prior participation in one of dr. bober's sexual health workshops

Keywords: breast cancer survivors sexual function disturbances ovarian suppression treatment
additive effects of alternative nostril breathing with pharmacological management on dyspnea and control pause in patients with bronchial asthma

Conditions: Bronchial Asthma

Summary: bronchial asthma is a widespread chronic condition charactrized by inflammation and narrowing of airways, leading to repeateted episodes of breathlessness, wheezing and labored breathing.breathing exercises help to manage hyperventilation often seen in asthmatic patients. to handle respiratory complications asthmatics are advised to practise nasal breathing techniques in conjunction with their prescribed medications.

bronchial asthma is a very common chronic disease marked by inflammation and constriction of airways, resulting in recurrent episodes of breathlessness, wheezing and decrease work of breathing. breathing exercises help to manage hyperventilation associated with asthma. in order to manage respiratory conditions asthmatic patients are encouraged for nasal breathing techniques along with pharmacological management. hence the objective of the study is to compare the effects of alternative nostril breathing along with pharmacological management versus pharmacological management alone on dyspnea, control pause, asthma control and peak expiratory flow rate in patients with bronchial asthma.

Eligibility criteria:
inclusion criteria: * adults: aged (18-45 years) * gender: both males and females * grade1- grade 4 on modified mrc dyspnea scale * asthma severity classes (intermediate, mild persistent and moderate persistent asthma) acc. to naepp national asthma education and prevention program guidlin exclusion criteria: * patients having acute exacerbation of copd or status asthmaticus * patients diagnosed with acute infections * patients unable to follow command/ instructions * asthma patients with \>40 sec control pause duration * patients who fall in red zone of asthma action plan (pefr \< 50%)

Keywords: dyspnea, asthma control, peak expiratory flow rate
efficacy, safety, tolerability and pharmacokinetics of kae609 in adult patients with acute, uncomplicated plasmodium falciparum or vivax malaria mono-infection

Conditions: Malaria

Summary: this study will assess efficacy, safety , tolerability and pk in uncomplicated adult malaria patients with p. vivax or p. falciparum infection after 3 day dosing with kae609 at 30 mg/day


Eligibility criteria:
inclusion criteria: * male and female patients aged 20 to 60 years * presence of mono-infection of p. falciparum or p. vivax * weight between 40 kg to 90 kg exclusion criteria: * patients with signs and symptoms of severe/complicated malaria * mixed plasmodium infection * presence of other serious or chronic clinical condition requiring hospitalization. * severe malnutrition * significant chronic medical conditions which in the opinion of the investigator preclude enrollment into the study other protocol-defined inclusion/exclusion criteria may apply.

Keywords: acute malaria kae609
virtual reality games in pediatric surgery

Conditions: Analgesia; Surgical Procedure, Unspecified; Immersion

Summary: randomized controlled trial reporting the pain levels and pain control/reduction of children at the age of 6-15 undergoing surgical procedures by using virtual reality gaming (vr) compared to nitrous oxide. therefore, 50 patients in each treatment group are recruited, resulting in 100 children altogether. the pain levels and pain control/reduction is measured by the standard anesthesia protocol normally used when nitrous oxide is applied and questionnaires that are administered to the patients at baseline and two weeks after surgery including both the primary and secondary outcome.


Eligibility criteria:
inclusion criteria: * indication to undergo an elective minor surgical procedure (removal of percutaneous osteosynthesis or pin material or dressing change) * written informed consent by parents * written informed consent by patient if patient is 14 or 15 years old exclusion criteria: * inability to understand the vr-program * inability to fill in the questionnaire because of language deficiencies * neurologic disorders * respiratory tract infections * intolerance of the vr headset or vr gaming procedure
comparison of chitodex gel vs nexfoam on post-operative outcomes in the treatment of chronic rhinosinusitis

Conditions: Chronic Rhinosinusitis

Summary: the purpose of this study is to compare the efficacy and outcomes of chitodex gel plus kenalog versus nexfoam plus kenalog in patients with chronic rhinosinusitis (crs) undergoing sinus surgery. both dressings are already known to be beneficial in controlling postoperative bleeding and promote wound healing.

the trial will be single blinded randomized controlled trial and patients recruited will undergo endoscopic sinus surgery as standard of care for treatment of crs. specific outcome measures will be objective and subjective outcome scores post surgery.

Eligibility criteria:
inclusion criteria: 1. those who have had symptoms of chronic rhinosinusitis (nasal discharge, postnasal drip, nasal obstruction, facial pain and pressure, lack of sense of smell) that has been previously persistent for greater than 3 months and 2. ≥ 18 years to ≤ 90 years and 3. english speaking and 4. able to give written informed consent and 5. local residents who will be returning to this center for postoperative follow-up care and 6. indicated to undergo endoscopic sinus surgery and willing to return at 2-4, 6-8 \& 12 (± 2) weeks post-op. exclusion criteria: 1. allergy to shellfish 2. pregnant or breastfeeding 3. hepatitis or blood disorders 4. any drug allergy 5. allergy to potato starch (due to nexfoam)
managing changes in life after deep brain stimulation for parkinson's disease

Conditions: Parkinson's Disease

Summary: parkinson's disease is a chronic progressive neurological disorder. symptoms are tremor, slowness in movement, rigidity and postural instability. as the disease progresses and treatment with l-dopa is no longer sufficient, some patients may be treated with deep brain stimulation. when treated with deep brain stimulation, electrodes are inserted in the affected area of the brain and through stimulation, motor symptoms of parkinson's disease are significantly reduced. during the first year of dbs treatment patients and spouses may experience changes in everyday life and illness trajectory posing new opportunities as well as new challenges. the purpose of the study is to develop an individualised and targeted nursing program to support patients and relatives manage changes and challenges in life the first three months after deep brain stimulation. the intervention is expected to generate important knowledge that will serve as a foundation for the further development of a future nursing program.

the intervention is designed as a psychosocial intervention, targeted both patients and spouses. the intervention consists of individually targeted meetings with a specialized dbs nurse several times during the first six months og dbs. patients and spouses likewise have to fill out a diary for use in the meetings. all meetings have specific topics, addressing aspects of challenges in adjusting to dbs, and the aim is to off patients and spouses a tailored intervention, supporting each individual based on an individual assessment.

Eligibility criteria:
inclusion criteria: * eligible and offered treatment with dbs for pd * married or cohabitant exclusion criteria: * living alone

Keywords: patients nursing parkinsons disease deep brain stimulation spouses
blood donation--immune sequelae and recruitment

Conditions: Blood Disease; Blood Donors

Summary: to determine if there were immune sequelae related to the long-term donation of blood or blood products.

design narrative: the study had two objectives. the first objective was to investigate changes in immune function which may have occurred as a result of blood, plasma, or platelet donations. preliminary studies had shown evidence of alterations in immune parameters in normal apheresis donors with the most marked changes occurring in long-term plasmapheresis donors. to ascertain whether donation of blood or blood products altered specific immune parameters, studies were conducted on white blood cell (wbc) receptors known to be involved in normal host defense mechanisms, lymphocyte subpopulations, plasma proteins, and complement activation products from 30 individuals in each of four separate donor groups: whole blood donors, bulk plasma donors, plasma donors stimulated with incompatible rbc, and platelet donors. donor immune data were compared with results in nondonor controls and were also correlated with demographic data, donation history, laboratory data, and clinical findings. the second objective of the study was to determine if changes in an individual donor's immune status occurred over time. a longitudinal study of 15 new donors in each donation group was performed to evaluate alterations in immune function that may have occurred in committed donors of blood products and whether there was any clinical significance to the findings. new donors were enrolled in donation groups and followed longitudinally for a period of up to two years. the study was extended through january, 1997 on fy 1995 funds.

Eligibility criteria:
no eligibility criteria
evaluate the efficacy and safety of lomitapide in pediatric patients with homozygous familial hypercholesterolemia on stable lipid-lowering therapy

Conditions: Homozygous Familial Hypercholesterolemia

Summary: this is a phase 3 single-arm, open-label, international, multi-center clinical trial to evaluate the efficacy and safety of lomitapide in pediatric patients with hofh who are receiving stable lipid-lowering therapy, including ldl apheresis. the study is comprised of a 12-week run-in period, a primary 24-week efficacy phase, followed by an 80-week safety phase.


Eligibility criteria:
inclusion criteria: 1. male or female aged ≥5 and \<18 years with diagnosed functional hofh 2. patient must weigh at least 15 kg and be at or above the 10th percentile in bmi and at least 10th percentile in height for age and gender based on cdc growth charts 3. negative pregnancy test at screening and during the study for females of child bearing age 4. potentially sexually active female patients who are of child-bearing age must either be sexually abstinent or follow two acceptable methods of contraception exclusion criteria: 1. other forms of primary hyperlipoproteinemia and secondary causes of hypercholesterolemia (e.g., nephrotic syndrome, hypothyroidism). 2. abnormal liver function test at screening 3. moderate or severe hepatic impairment or active liver disease 4. serum creatine phosphokinase (cpk) level \>2 × uln. 5. chronic renal insufficiency 6. history of drug abuse within the last 3 years or habitual alcohol consumption 7. new york heart association (nyha) class iii or iv congestive heart failure. 8. uncontrolled hypertension 9. in the judgment of the pi, precocious or delayed puberty or endocrine disorder that would affect growth 10. history of non-skin malignancy or other cancers occurring within the past 3 years 11. history of inflammatory bowel disease or other malabsorption syndrome or a history of bowel resection, gastric bypass, or other weight loss surgical procedure. 12. use of mipomersen within 6 months of screening. 13. any medical condition for which the life expectancy is predicted to be less than 5 years. 14. any patient who is unable to avoid treatment with strong or moderate cytochrome p450 3a4 (cyp3a4) inhibitors, or other drugs contraindicated for use with lomitapide during the study. 15. participation in an interventional clinical study within 6 weeks for a statin therapy or within 6 months for any other unapproved therapy.

Keywords: hofh
trial of protein supplement on vertebral fusion in posterior spine fusion surgery

Conditions: Spine Surgery

Summary: receiving protein can affect the bone formation and maintenance by providing a structural matrix of the bone, optimizing the level of igf-1, increasing intestinal calcium absorption, transferring phosphorous, and improving muscle strength.therefore, protein may be effective on vertebral fusion by such mechanisms. in this trial patients undergoing elective posterior spine fusion surgery are divided into two groups of intervention or control.

a randomized, double blind, controlled trial will be conducted in patients undergoing elective posterior spine fusion surgery in tehran, iran. after a full review of the inclusion and exclusion criteria and explanation of the risks and benefits of the study, written consent form will be completed. the participants are 80 eligible posterior spine fusion surgery patients, aged ≥ 18 years. intervention patients will be received 36 grams of protein supplement along with diet containing 1.2 g/kg/day of protein for 30 days after surgery and control patients will be received carbo mass along with diet containing 1.2 g/kg/day of protein 30 days after surgery. patients will be evaluated for occurrence of vertebral fusion and enhanced recovery after 3 months surgery.

Eligibility criteria:
inclusion criteria: * adult patients 18-65 years * body mass index 18.5-30 * candidate for the elective posterior spine fusion * without history of severe liver disorder * without history of kidney disorder * without history of diabetes * without history of trauma and fracture of the vertebral * without history of osteoporosis * without history of gastrointestinal malabsorption * without history of parathyroid gland disorders * without taking medications that affect the metabolism of bone, such as calcitonin, * bisphosphonate, corticosteroid * no smoking * serum level of vitamin 25 (oh) d ≤20 ng/l exclusion criteria: * allergy or intolerance to protein or maltodextrine supplement * unwillingness to continue cooperation

Keywords: protein supplement protein diet vertebral fusion enhanced recovery after surgery infection wound healing pain
effect of low amplitude vibration therapy on flexibility of hamstring muscle in athletes of pakistan

Conditions: Hamstring Contractures; Whole Body Vibration

Summary: whole body vibration therapy is rapidly becoming a topic of interest for the researchers around the world. evidence suggests that whole body vibration has an effect on improving flexibility of hamstring muscle and balance in athletes. the purpose was to examine the effect of low amplitude whole body vibration on the flexibility of hamstring muscle and improving balance in athletes of pakistan

a total 60 number of athletes were analyzed and out of these 40 were included in the study who full fill the inclusion criteria, selected athletes were randomly assigned into two groups (control \& experimental). after a total 2 drop outs from control group and 3 drop outs from experimental group, there were 18 athletes in control group and 17 in experimental group who continued till the analysis. experimental group was given five sessions of low amplitude whole body vibration therapy for almost duration of 10 minutes, on alternative days, along with static stretching of hamstring muscles for 5 minutes and the control group was given only the static hamstring muscle stretches for five minutes, and same five sessions alike on alternative days. static stretching protocol had 10 stretches in total with 15 seconds stretch time and 30 seconds relaxing time of hamstring muscle. all participants were assessed using biodex whole body vibration plate, biodex balance system , goniometer and a questionnaire.

Eligibility criteria:
inclusion criteria: * national athletes of pakistan. * age between 18-30 years exclusion criteria: * athletes having history of any acute injury within last 6 weeks. * athletes who have had any surgical procedure previously or patients who were medically unstable.

Keywords: whole body vibration hamstring flexibility rom balance postural stability index