Kornimate/medical-research-clean huggingface dataset:
characterization of persistent pulmonary abnormalities following covid-19 pneumonia

Conditions: Pneumonia, Viral

Summary: severe acute respiratory syndrome (sars) sars-cov-2, name of the coronavirus group of international committee on taxonomy of viruses, is an emerging virus from the family of coronaviridae, responsible for the covid-19 pandemic. this infection can progress to viral pneumonia, and in 3% of cases up to acute respiratory distress syndrome (ards) which conditions the prognosis of the disease. due to its unusual clinical presentation with a risk of sudden deterioration on the 8th day as a result of possible hyperinflammatory response, the respiratory impairment of covid is unique and many questions remain unanswered concerning its evolution once the acute phase has passed. knowledge of the evolution of pulmonary involvement, particularly in patients requiring hospitalization, can help reduce the morbidity linked to the persistent abnormalities identified by establishing early therapeutic management. it can also provide a better understanding of the mechanisms of pulmonary involvement in the acute phase. current data regarding the acute phase of covid-19 suggest that persistent abnormalities remain distant from this infection at all levels of the respiratory system: gas exchange, perfusion, ventilatory mechanics, and interstitial lung disease. the main objective is to characterize persistent gas exchange anomalies 4 months after documented covid-19 pneumonia, resulting in oxygen desaturation and requiring hospitalization.


Eligibility criteria:
inclusion criteria: * patient with covid-19 pneumonia * positive pcr for covid-19 on respiratory sample (saliva, nasopharyngeal, bronchial, tracheal aspiration or lba) * having required hospitalization in the pulmonology service, intensive care in pneumology or resuscitation service at the toulouse university hospital * saturation \<94% in ambient air at diagnosis * patient having a chest ct-scan proving pneumonia during his hospitalization * patient ≥ 18 years old * patient who has given written consent to participate in the study exclusion criteria: * patient hospitalized for pneumonia not documented by a chest ct-scan * patient with negative covid pcr * patient known before the episode of covid-19 pneumonia for a respiratory or cardiac pathology which can lead in itself to an alteration of gas exchanges * patient under curators / guardianship * pregnant patient * minor patient * absence of consent for participation in the study * medical condition that does not allow for pulmonary function test

Keywords: covid-19 respiratory function tests pulmonary gas exchange : respiratory tract diseases pulmonary embolism respiratory distress syndrome
real world evidence of pd-l1, tmb prevalence and efficacy of 1st line chemotherapy in these high or low population for stage iv urothelial cancer

Conditions: Urologic Neoplasms

Summary: this study is a multi-center, non-interventional study. patients' background, treatment pattern, treatment outcome, efficacy will be collected from medical records in stage iv urotherial (uc) patients. archived patient's formalin-fixed paraffin-embedded (ffpe) primary tumor samples will be collected to assay pd-l1 expression and next generation sequencer (ngs) assay for tumor mutation burden (tmb).

this study is a multi-center, non-interventional study. patients' background, treatment pattern, treatment outcome, efficacy will be collected from medical records in stage iv urotherial (uc) patients. archived patient's formalin-fixed paraffin-embedded (ffpe) primary tumor samples will be collected from each site and conduct programmed cell death 1 ligand 1 (pd-l1) assay and next generation sequencer (ngs) assay for tumor mutation burden (tmb). based on these data, prevalence of pd-l1, tmb and overall survival (os), progression free survival (pfs) from start of 1st line treatment in stage iv will be assessed. in this study, 150 patients will be enrolled from approximately 30 sites in japan. the patients should have received at least 1 cycle of chemotherapy and never receive immune oncology drug as 1st line treatment in stage iv. the patients will be enrolled continuously from the 1st patient who is enrolled in this study until target number of patients in each site.

Eligibility criteria:
inclusion criteria: * age \> 20, japanese men and women. * patients who have started at least 1 cycle of chemotherapy. * patients who provided informed consent by appropriate methods. in dead case, optout will be applicable. * patients who are diagnosed as stage iv (t4b, any n or any t, n2-3 or m1) uc between january 1st in 2017 and december 31st in 2018. * patients who have ffpe primary tumor sample collected after january 1st in 2017. the sample should be collected before any therapies including 1st line treatment in stage iv and therapies in stage iii and other stages. it is possible to send sliced undyed section of primary tumor including 1 he-stained section of same sample in case that patients cannot send ffpe primary tumor block. exclusion criteria: -patients who are prior exposure to immune-mediated therapy as 1st line treatment in stage iv.

Keywords: real world, pd-l1, tmb, stage iv, urothelial cancer, japanese
effect of wbt for ci with depression

Conditions: Chronic Insomnia; Depression Disorders

Summary: this randomized controlled trial aims to explore the therapeutic effects of well-being therapy (wbt) on patients with chronic insomnia accompanied by depressive symptoms.

according to dsm-iv criteria, approximately 6%-10% of the adult population in industrialized countries suffer from chronic insomnia (ci), characterized by difficulties in initiating or maintaining sleep accompanied by daytime symptoms persisting for at least four weeks. chronic insomnia often leads to various psychiatric symptoms, with depressive symptoms being among the most common. for patients with ci and comorbid depressive symptoms, the most common treatment involves the use of antidepressant medications. however, while depressive symptoms may improve, insomnia symptoms often persist. among non-pharmacological interventions aimed at promoting psychological well-being, well-being therapy (wbt) stands out as a brief and innovative psychotherapeutic approach. wbt is a structured, manualized, short-term therapy that incorporates self-monitoring of well-being episodes through the use of a diary, cognitive restructuring of interfering thoughts and behaviors, and homework assignments. previous research has demonstrated the effectiveness of wbt in alleviating stress in populations experiencing 'allostatic load.' this study seeks to evaluate the therapeutic effects of six wbt sessions on individuals with ci and comorbid depressive symptoms.

Eligibility criteria:
inclusion criteria: 1. diagnosed with insomnia disorder according to dsm-5 criteria, with a duration of at least 3 months. 2. pittsburgh sleep quality index (psqi) total score \> 5. 3. age 8 years or older. 4. educational level of at least junior high school. 5. voluntarily agree to participate and provide written informed consent. 6. presence of depressive symptoms, defined as hamilton depression scale (hamd) score ≥ 16. exclusion criteria: 1. presence of severe physical illnesses or major psychiatric disorders, or at risk of suicide. 2. diagnosed or suspected of having sleep breathing disorders, restless legs syndrome, circadian rhythm sleep disorders, or engaged in shift work. 3. pregnant or breastfeeding women. 4. currently undergoing any psychological therapy.

Keywords: chronic insomnia depression disorders well-being therapy
effect of exercise on renal function in predialysis

Conditions: Chronic Kidney Disease

Summary: the proposed research aims to examine whether regular aerobic exercise can preserve renal function, improve aerobic capacity, physical and psychosocial function, strength, cardiovascular function, general well-being and quality of life. ultimately, the research aims to prove that exercise is a more cost-effective and a more efficient use or healthcare resources used in the treatment of patients with ckd. exercise is a relatively cheap treatment option which is readily available and accessible for this patient population. establish if, compared with usual care, an exercise programme for pre-dialysis ckd patients; 1. preserves renal function. 2. improves aerobic capacity, physical and psychosocial function, strength, cardiovascular function, general well-being and quality of life.


Eligibility criteria:
inclusion criteria: * - stages 3-4 chronic kidney disease (ckd) patients (glomerular filtration rate (gfr) 20-60 ml/min) * male or female * aged \>18 years * written informed consent exclusion criteria: * pregnancy * requiring support for ambulation less than 20m * vasculitis, * proliferative diabetic retinopathy, * severe osteodystrophy, * uncontrolled diabetes, * psychiatric illness, including anxiety, mood and untreated eating disorders * infection or course of antibiotics within the last month

Keywords: exercise rehabilitation kidney function cardiovascular disease risk
evaluation of preventive regimens with different toothpastes vs fluoride varnish & toothpaste in high caries patients

Conditions: Dental Caries

Summary: this study will be conducted in order to determine the prevention effect of caries preventive regimen using herbal toothpaste and regimen using fluoride toothpaste versus fluoride toothpaste and fluoride varnish on the caries risk of patients with high caries risk.

dental caries is highly predominant worldwide. so, in addition to treating this caries, patients should be managed to avoid new caries. preventive measures could be applied to the patients who are most expected to develop dental caries who are identified by caries risk assessment. thus, effective caries risk assessment is essential to control new caries development. dental caries can be prevented by conducting appropriate measures; therefore, it is crucial to identify those who are most likely to have dental caries by caries risk assessment and giving them the essential preventive measures. though some caries preventive measures have showed success in descriptive clinical trials, there is little information on their practicality with high caries risk groups in everyday usage. oral health is an essential part of general well being, people have used herbs in order to prevent dental diseases for centuries. in 2008 the federal council of dentistry approved the use of medicinal plants for oral healthcare. medicinal plants can heal bacterial diseases as it is full of antimicrobial agents. they are becoming more popular than chemicals due to the side effects of synthetic antibiotics and the antibiotic resistance in microorganisms. studies propose that herbal extracts are highly effective against significant microorganism which cause dental caries like streptococcus mutans. herbal toothpaste decreases dental caries through combined effects of antibacterial agents, oral acid neutralisers and decreased plaque bacterial enzyme inhibitors present in the herbal toothpaste.

Eligibility criteria:
inclusion criteria: * healthy patients with free medical history. * age range 15-50 years. * patients with high caries risk assessment due to increased cariogenic bacteria according to cariogram. * low fermentable carbohydrates diet patient * not under antibiotic therapy either at the time of the study or up to the last month before the start of the study. exclusion criteria: * patients with a compromised medical history. * cariogenic diet patient. * extreme plaque accumulation and periodontal problems * participants with a history of allergy to any of the drugs or chemicals used in the study. * patients on any antibiotics during the past month
hyperglycemia, exercise, and endothelial function

Conditions: Endothelial Function; Hyperglycemia

Summary: the main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. all subjects will consume a sugary beverage three times daily for seven days. subjects will be randomly assigned to either the glucose with (glu+ex) or without (glu) structured exercise group.

acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. it remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.

Eligibility criteria:
inclusion criteria: - healthy young men 18-35 years of age. exclusion criteria: * hypertension, * hyperlipidemia, * smoking, * heart disease, * chest pain upon exertion, * previous heart surgeries or history of arrhythmias, * diabetes, * obesity (body mass index ≥30kg/m2), * kidney disease, * pulmonary disease, * autonomic disorders, * individuals whom engage in structured exercise (≥30min, ≥2d/wk), * current use of medications which influence outcome measures

Keywords: exercise glucose vascular function
dailies total1® soft contact lenses - post-market clinical follow-up study

Conditions: Myopia; Hyperopia; Presbyopia; Astigmatism

Summary: the purpose of this study is to continuously assess the visual performance and safety of dailies total1 soft contact lenses in a real world setting and broader patient base through routine clinical practices. this activity will be used to continuously support delefilcon a (sphere, toric, and multifocal) soft contact lens regulatory requirements and standards.

this study includes a baseline visit and a year 1 visit. the baseline visit is defined as the first office visit where an eye care professional provided an in-person office biomicroscopy exam to the subject before or during which a dailies total1 sphere, toric, or multifocal soft contact lens prescription was released. the baseline visit will be retrospective. all assessments at baseline will be obtained from chart reviews. the year 1 visit is defined as the visit that occurs 1 year (-2/+4 months) since the baseline visit during which period the subject is wearing prescribed lenses and a contact lens examination is performed. the year 1 visit can be either retrospective or prospective in subjects 7 to less than 18 years of age. for subjects 18 years of age and older, the year 1 visit will be retrospective.

Eligibility criteria:
key inclusion criteria: * at baseline: 7 years of age or older for sphere and toric wearers, 40 years of age or older for multifocal wearers. * wearers of delefilcon a (sphere, toric, or multifocal) soft contact lenses of the same design in both eyes who have already begun use of the lens type and have purchased at least 3-month supply of lenses at baseline. * best corrected distance visual acuity (bcva) 20/25 or better in each eye at baseline. * other protocol-defined inclusion criteria may apply. key exclusion criteria: * any ocular disease or condition that would contraindicate contact lens wear at baseline. * use of systemic or ocular medications that would contraindicate contact lens wear at baseline. * other protocol-defined exclusion criteria may apply.

Keywords: contact lenses
usage of acyclovir for suppression of hiv-1 and hsv-2 coinfected persons in cameroon

Conditions: HIV-1 and HSV-2 Coinfection; HIV Infections

Summary: the study proposed that both clinical and subclinical hsv reactivation is associated with increased hiv shedding from mucosal surfaces, which may increase the infectiousness of hiv-1/hsv-2 coinfected persons. to test this hypothesis, we will control hsv reactivation with acyclovir, a safe medication that is proven to reduce hsv shedding, and measure hiv levels in blood, genital, and pharyngeal secretions. the study hypothesizes that acyclovir will reduce hiv shedding from mucosal surfaces of hiv-1/hsv-2 coinfected individuals.

the main objective is to assess the reduction in genital hiv-1 shedding associated with daily acyclovir for suppression of hsv-2 reactivation. all patients will be treated with the usual antibiotic treatment for any sexually transmitted infections that are diagnosed during the study. in addition, half will receive acyclovir for 8 weeks , whilst the other half will receive a placebo for 8 weeks. the study medication will reverse in the second 8 weeks of the study. the patients will attend the clinic 3 times per week during the first and the last 8 weeks of the study and once every week during the washout period in the middle of the study - for a total of 18 weeks per participant. at each visit genital and oral samples will be collected. a blood sample will also be collected. for women participants, pregnancy test will be performed. the clinic will provide both pre- and post-hiv test counseling.

Eligibility criteria:
inclusion criteria: * 18 years old and above * documented hiv-seropositive * hsv-2 seropositive as determined by focus eia * not intending to move out of the area for the duration of study participation * willing and able to: 1. provide independent written informed consent 2. undergo clinical evaluations 3. take study drug as directed 4. adhere to follow-up schedule * bacterial stds (symptomatic std syndromes or laboratory-confirmed asymptomatic gonorrhea, chlamydia, syphilis) are treated within two weeks if study enrollment and random assignment. exclusion criteria: * women who meet any of the following criteria are not eligible for this study. 1. known history of adverse reaction to acyclovir 2. planned open label use of acyclovir, valacyclovir, or famciclovir 3. positive pregnancy test 4. active opportunistic infection

Keywords: hiv-1 hsv-2 coinfection africa cameroon
pcr cycle threshold values and covid-19 outcomes

Conditions: Covid19

Summary: this is a retrospective observational study. the study will use high quality, reliable data that has already been collected for the isaric 4c covid-19 study in order to analyse the relation between predictor variables (laboratory polymerase chain reaction \[pcr\] cycle threshold \[ct\] values) and outcomes for covid-19 disease within a hospitalised population.

currently, in the united kingdom, the recommended method for diagnostic testing and screening for covid-19 is quantitative (real-time) reverse transcription polymerase chain reaction (pcr) analysis of viral rna extracted from upper respiratory tract samples. a positive result indicates that sars-cov-2 rna has been detected with a cycle threshold (ct) value of less than 38 cycles of amplification (n.b. this is a locally agreed value, which is based on analysis of proficiency testing performance and other local testing data. cycle threshold (ct) values inversely correlate to the amount of target nucleic acid in the sample. thus, a lower cycle threshold (ct) value indicates a greater amount of target nucleic acid in a sample i.e. a higher viral load. a recent scoping literature review has revealed only a handful of published studies to date that explore an association between cycle threshold (ct) values and disease severity or clinical outcome in patients infected with the sars-cov-2 virus. the majority of these studies have been conducted in china with small patient sample sizes. thus, a larger-scale study which explores the relationship between viral load and disease severity is required; indeed, the world health organization (who) has recently highlighted this as an area which needs further research.

Eligibility criteria:
inclusion criteria: 1. adult (aged 18 years and over) patients presenting to uhnm with confirmed sars-cov-2 infection and who are enrolled onto the isaric covid-19 study. 2. patients who have undergone an initial diagnostic or screening test for sars-cov-2 (from an upper respiratory tract sample) and a cycle threshold (ct) value is available on the uhnm laboratory database. exclusion criteria: 1. paediatric patients (under 18 years). 2. patients without a pcr ct result on the uhnm laboratory database 3. patients without confirmed sars-cov-2 infection 4. patients who were not enrolled in to the isaric covid-19 study
development of eating disorders symptoms among children

Conditions: Eating Disorders Symptoms

Summary: randomized clinical trial, the research will be composed of two parts in order to examine the research question: a combination of controlled randomized retrospective research and prospective cohort research prospective cohort research: the research groups - families coming for treatment in "active maccabi" clinics in the northern region, israel. approximately 30 families. retrospective random controlled research 1. the research group - families that have completed an intervention program of "active maccabi" northern region, israel,within the past two to three years. the families will be requested to attend a follow-up meeting of all family members in which they will answer questionnaires. approximately 66 families. 2. the control groups - families who did not participate in the program who have a child between the age 7-14 who has suffered from obesity/weight (over the past 2-3 years), in correlation with the child in the intervention group. approximately 66 families. hypotheses of the research: 1. status of the weight of the child being treated and of his siblings will be higher than that at the end of the program. 2. indication of the obesogenic environment of families participating in the program will be lower in comparison with families not participating in the program. 3. the rate of eating disorder symptoms among children who participated in the program will be lower in comparison with those of the obese/overweight child in families who were not the program. 4. the rate of eating disorder symptoms among siblings who participated in the program will be lower than that of siblings in families not in the program.

duration of the research -prospective cohort research: 6 months of intervention. 8 months follow-up. research instruments 1. anthropometric measurements of all children in the family (height, weight and bmi). bmi per centile examinations according to age. 2. an acquaintance questionnaire and demographic details - to be answered by parents 3. a feaq_r questionnaire to be answered by the parents (only in the prospective research group). the questionnaire will examine the obesogenic burden in the family. a column will be added for each sibling of relevant age. the questionnaire will be valid in english and hebrew. the psychometric characteristics of the questionnaire: alpha cronbach - validity 0.84; reliability 0.78 trt 4. eat-26 (cheat) questionnaire to be answered by the children and their siblings. the questionnaire will examine the risk of developing an eating disorder.

Eligibility criteria:
inclusion criteria: 1. families who participated in "active maccabi 2. families who signed a consent form 3. families who attended 80% of the sessions exclusion criteria: 1. families who don't fill in questionnaires at all stages of the research 2. families in which the parents refuse to sign a consent form 3. families in the control group who receive treatment in more than three sessions by a dietician in the community

Keywords: eating disorder childhood obesity family based treatment