Kornimate/medical-research-clean huggingface dataset:
thyroid dysfunction in female patients with acne vulgaris: [ relation to other variables ]

Conditions: Acne Vulgaris; Thyroid Dysfunction

Summary: acne is a chronic inflammatory disease of the pilo-sebaceous unit with a multi-factorial etiology. it is one of the most frequent cutaneous diseases, affecting more than eighty percent of the population at some point in their lives . endocrine factors especially androgens and steroids are one of multiple factors provoked to be involved in pathogenesis of acne . thyroid hormones have steroid like action that have many regulatory functions in many body organ functions including skin and pilosebaceous unit. furthermore, subtle thyroid dysfunction was shown to have a role in many disease conditions. thyroid hormone action on sebaceous glands is unclear. in hypothyroid states, sebocytes exhibit reduced rates of secretion that increases with thyroxine administration .

most of studies about thyroid dysfunction in acne patients focused on adult acne population especially females and searched for presence or absence of associating anti-thyroid antibodies with controversial results . some other studies were concerned with the impact of acne treatments as tetracycline, isotretinoin or radiotherapy on thyroid pathologies and dysfunction . global acne severity scale (gags) is a simple, accurate, fast method for the determination of severity of acne, and it requires no special equipment and is relatively cost-effective. its personal and interpersonal differences is low and it was first used by doshi and his colleagues in 1997 in usa . to the best of knowledge, little is published about thyroid dysfunction in acne female patients of different age categories and correlating thyroid function with other important patient and acne variables as body mass index (bmi) , age (starting from 16 years) , acne type, severity and duration.

Eligibility criteria:
inclusion criteria: * patient with acne vulgaris from females only with different ages (starting from 16 years) , bmi groups. exclusion criteria: * female patients with clinically diagnosed thyroid disease. * female patients receiving isotretinoin or minocycline in the last 6 months * female patients who were subject to radiotherapy or surgery in neck region.

Keywords: acne vulgaris thyroid dysfunction
the early impact of postoperative bracing on pain and quality of life following posterior instrumented fusion for lumbar degenerative conditions

Conditions: Lumbar Degenerative Conditions

Summary: braces are commonly prescribed after posterior spinal instrumented fusion (psif) in patients with lumbar degenerative conditions with the aim of improving pain relief and quality of life. however, there is a lack of evidence on the indication for postoperative bracing, as surgeons choose to use braces mainly based on their experience and training. the aim of this study is to investigate whether wearing a brace after psif can improve pain relief and quality of life (qol) 6 weeks and 3 months after surgery.


Eligibility criteria:
inclusion criteria: * patients with degenerative lumbar spine disease (degenerative spondylolisthesis, spinal stenosis, or degenerative disc disease); * patients scheduled for an elective posterior spinal fusion. exclusion criteria: * patients with obesity (bmi \> 35kg/m2).

Keywords: post-operative bracing rigid lumbosacral orthosis posterior spine fusion quality of life lumbar degenerative conditions
post-emergency management of patients with transient ischemic attack

Conditions: Transient Ischemic Attack

Summary: a transient ischemic attack (tia) is a momentary neurological dysfunction due to a brief cessation of blood flow to a region of the brain, resulting in typical signs of stroke (hemiplegia, aphasia, dysarthria), but whose clinical symptoms typically last less than an hour, with no visible lesion on imaging. this diagnosis remains difficult and is essentially based on the clinical judgment of the physician. because a tia can be a "pre-alarm" for stroke in 20-30% of cases, it needs to be treated appropriately and as early as possible in the emergency department. stroke rates after untreated tia are 5% within 48 hours, 10% within one month and 20% within one year. this risk is calculated using the abcd² score which is based on the patient's risk factors and the clinical manifestations of tia. patients with a score ≥ 3 should be hospitalized as soon as possible for a complete medical evaluation. however, this score has not been scientifically validated, and several specialists agree that all tias should be evaluated immediately. preventing stroke is a major public health issue because it is a serious, disabling and sometimes fatal disease. given the seriousness of the progression from tia to stroke, the french national authority for health has issued a series of management recommendations. however, in practice, these guidelines remain complicated to follow and patients management may vary and be more or less effective. therefore, the aim of this study is to highlight the differences in how inpatients and outpatients are managed. following these observations, solutions will be sought to make the care and management of these patients more efficient and more in line with recommendations.


Eligibility criteria:
inclusion criteria: * patient over 18 years old. * consultation in the emergency department. * suspected tia diagnosed by emergency physician. * duration of tia symptoms \<1 hour. exclusion criteria: * validation mri performed prior to suspected tia. * patient hospitalized for a condition other than tia, including stroke. * patient referred to another hospital for further examination. * pregnant women. * patient unable to understand and answer a questionnaire. * patient under legal protection.

Keywords: emergency cerebral rmi guidelines compliance
preventing excessive gestational weight gain in obese women

Conditions: Obesity

Summary: the purpose of this study is to study the effects of a multicomponent lifestyle intervention that includes partial meal replacements as a means to prevent excessive gestational weight gain in obese women. the primary hypothesis is that the intervention will reduce the rate of gestational weight gain compared with standard care.


Eligibility criteria:
inclusion criteria: * over 18 years old * \< 16 weeks gestation * bmi \>= 25 * willing to consent exclusion criteria: * pregnant with twins * untreated medical or psychological problem * inability to be physically active

Keywords: overweight obese pregnancy weight gain
comparison of transversus abdominis plane block and erector spinae plane block in inguinal hernia repair

Conditions: Postoperative Pain

Summary: multimodal analgesia is used to control postoperative pain in inguinal hernia repair. transversus abdominis plane block is an effective regional anesthesia technique for postoperative analgesia in inguinal hernia repairs. the erector spinae plane block applied to thelow thoracic region was also reported to provide effective analgesia in these surgeries. in this study, we aimed to determine and compare the effects of transversus abdominis plane block and lumbar erector spinae plane block on postoperative pain in inguinal hernia repairs.


Eligibility criteria:
inclusion criteria: * inguinal hernia repair under spinal anesthesia, asa 1-2-3 exclusion criteria: * patient refusal * contraindications to regional anesthesia * known allergy to local anesthetics * bleeding diathesis * use of any anti-coagulants * inability to provide informed consent * severe kidney or liver disease * inability to operate pca system * patient with psychiatric disorders
can iron lessen anemia due to cancer and chemotherapy: a study to investigate the efficacy and safety of injectafer®

Conditions: Cancer and Chemotherapy Related Anemia

Summary: phase iii, multicenter, randomized, double-blinded, prospective study with two parallel treatment groups. patients who present to the hematologist/oncologist and satisfy all inclusion and exclusion criteria will be eligible for participation in this 18-week study.

this is a phase iii, multicenter, randomized, double-blinded, prospective study with two parallel treatment groups. patients who present to the hematologist/oncologist and satisfy all inclusion and exclusion criteria will be eligible for participation in this 18-week study. subjects who meet all inclusion criteria and no exclusion criteria, will be randomized into the trial (group a or b).

Eligibility criteria:
inclusion criteria: * subjects (male of female) ≥ 18 years of age able to give informed consent to the study. * subjects with non-myeloid malignancies * receiving chemotherapy as part of their cancer treatment with at least 4 weeks of treatment remaining. * screening visit central laboratory hemoglobin (hgb) ≤11 g/dl, but ≥8 g/dl. * ferritin between 100 and 800 ng/ml and transferrin saturation (tsat) =\<35% * subjects must have eastern coopertative oncology group (ecog) performance status of 0-2. * life expectancy of at least 6 months. * demonstrate the ability to understand the requirements of the study, willingness to abide by study restrictions and to return for the required assessments. exclusion criteria: * previous participation in a ferric carboxymaltose clinical trial. * known hypersensitivity reaction to any component of ferric carboxymaltose. * subjects with overt bleeding * any anemia treatment within 4 weeks before inclusion (oral iron, iv iron, transfusion, or erythropoiesis-stimulating agents). * subjects on erythropoiesis-stimulating agents. * requiring dialysis for the treatment of chronic kidney disease. * any non-viral infection. * known positive hepatitis with evidence of active disease. * received an investigational drug within 30 days of screening. * alcohol or drug abuse within the past 6 months. * hemochromatosis or other iron storage disorders. * any other laboratory abnormality, medical condition or psychiatric disorders which in the opinion of the investigator would put the subject's disease management at risk or may result in the subject being unable to comply with study requirements. * pregnant or actively trying to become pregnant (female subjects who are of childbearing age must have a negative pregnancy test at screening and be practicing an acceptable method of birth control during the study).
low-level laser therapy in patients with chronic fibromyalgia

Conditions: Chronic Pain

Summary: the purpose of this study is to examine the use of low level therapeutic laser (lllt) for its effects on pain, fatigue, and physical function in individuals with fibromyalgia.

fifty consenting participants with long-standing fibromyalgia (\> 3 mo duration) will be randomized to one of two treatment groups (n=25 per group) according to a computer generated randomization table. group 1 will be the 'sham' control group and group 2 will be the 'active' laser treatment group. the study will be conducted in a double-blind fashion using a standard 42 watt class iv laser which has a switch at the back of the device which allows the laser to operate in the 'inactive' mode despite giving the operator and patients the appearance of being active (e.g., generates skin warmth and a red beam of light). treatment will be administered three times/week for three weeks. data will be collected across the 3-week intervention and one week after completion of the intervention. data will be analyzed with appropriate statistical methods. the following outcome measures will be collected at baseline: (1)standardized sf-36 questionnaire; (2) symptom impact questionnaire; (3) current analgesic medication usage; (4) pressure-pain threshold testing over tender points; and (5) spinal range of motion with an inclinometer and accelerometer. outcome measures (2) and (3) will be re-assessed during the treatment phase at the end of weeks 1, 2 and 3. at 1 week and 1 month after the last laser/sham treatment session, all baseline assessments will be repeated, in addition to a global rating of change scale. any patient who reports any harm from the laser/sham treatments on the helpfulness scale will be queried for specific harm details.

Eligibility criteria:
inclusion criteria: 1. 18-80 years old 2. pre-existing medical conditions are under stable control 3. diagnosis of fibromyalgia by widespread pain index and symptom severity score 4. able to wear laser protective eyewear during the treatment session 5. ability to speak english and complete testing exclusion criteria: 1. presence of another pain syndrome that has anatomical overlapping with fibromyalgia pain 2. unstable psychiatric disorders or cognitive dysfunction or serious memory impairment 3. previous treatment with low level laser therapy 4. contraindication to receiving laser treatments 5. current use of photosensitive medication (has been instructed to minimize sun exposure) 6. active metastasis 7. active infection 8. impaired sensation
a cross-sectional and cohort study of covid-19 patients with post - discharge dysfunction

Conditions: Covid19; Respiratory Rehabilitation; Cross-sectional Study; Cohort Study

Summary: post-discharge rehabilitation regimens for covid-19 patients have not been supported by high-quality evidence-based medical evidence.the first part of this study is a cross-sectional study.the contents of the study were the factors related to the dysfunction of covid - 19 patients after discharge from the hospital in wuhan.the second part of this study is a cohort study.to observe the functional changes of covid-19 patients after discharge in hospital rehabilitation, home rehabilitation and no rehabilitation, in order to propose a more safe and effective rehabilitation program.


Eligibility criteria:
inclusion criteria: * patients with definite diagnosis of covid-19 normal or severe * patients who entered the isolation point \<3 days after discharge * 18-80 years old * agree to join the queue exclusion criteria: * body temperature \>38°c * heart rate \>120 times/min or \ 180mmhg, respiratory rate \>25 times/min in calm state.or above vital signs fluctuate significantly. * continuous oxygen therapy is required. * patients with myocarditis, pulmonary hypertension, congestive heart failure, fresh venous thromboembolic diseases, unstable fractures and other inappropriate exercise * patients with consciousness disorders, severe sequelae of cerebral infarction, cognitive dysfunction, mental disorders, severe balance disorders, and severe bone and joint diseases, which affect evaluation and treatment * other conditions that cannot be cooperated with rehabilitation treatment
antibiotic prophylaxis in gynecologic laparoscopy

Conditions: Infection Secondary to Surgical Procedure

Summary: laparoscopy is a surgical procedure indicated for most gynecological pathologies and presents numerous advantages over laparotomy, among them lower rates of surgical site infection and less comorbidity feverish. despite this, the use of antibiotic prophylaxis is widely accepted and performed by most gynecologists. however, there isn't literature evidence to support the routine use of antibiotics in the prophylaxis of wound infection on laparoscopic pelvic surgery .therefore, this study will evaluate the need for the use of antibiotic prophylaxis in gynecological laparoscopies not including opening hollow viscera.

it is a clinical, prospective, double-blind, randomized study. 114 women with gynecologic disease, in which there is indication of laparoscopic surgical approach, will be consecutively select. these women will be allocated in two arms, control and study, where control group will use placebo and study will receive intravenous cephazolin. these patients will be followed for 30 days according to centers for disease control and prevention criteria.

Eligibility criteria:
inclusion criteria: * patients with gynecologic disease, undergoing gynecologic laparoscopy without opening hollow viscera. exclusion criteria: * body mass index over 30 kg/m2 * smoking * diabetes type i or ii with glycated hemoglobin exceeding 6.5% * patients who are at surgical risk classification of the american society of anesthesiologists(asa) as asa iii or higher * refusal to participate * postoperative antibiotic therapy for another indication clinical complication

Keywords: laparoscopy surgical wound infection antibiotic prophylaxis gynecologic surgical procedures
obstetrics and gynecology residents and experts' knowledge of, attitudes toward, practice behaviors, and self-confidence levels of caring for lesbian, bisexual, and transgender (lbt+) patients in turkey; a descriptive-cross sectional study

Conditions: Knowledge, Attitudes, Practice

Summary: obstetrics and gynecology residents and experts' knowledge of, attitudes toward, practice behaviors, and self-confidence levels of caring for lesbian, bisexual, and transgender (lbt+) patients in turkey; a descriptive-cross sectional study

there are various studies about lgbt people's problems while utilizing healthcare services and interactions with physicians in turkey and other countries. there is a lack in the curriculum for obstetricians and gynecologists regarding lgbt individuals' healthcare problems. in this study, we tried to evaluate obstetrics and gynecology residents/experts' knowledge level about lgbt individuals, attitudes toward these sexual minority individuals in their clinical practices, practice behaviors and experience levels about this condition, and their confidence level about caring for sexual minority individuals by performing cross-sectional study using online survey platform.

Eligibility criteria:
inclusion criteria: * work actively as an obstetrician and gynecologist in istanbul/turkey exclusion criteria: * retired clinicians * lgbt individuals working as obstetrician and gynecologist

Keywords: lgbt attitude knowledge practice behaviour self confidence
influence of drainage on evd icp-signal

Conditions: Head Injury; Subarachnoid Hemorrhage

Summary: this observational study investigates icp signals obtained through an external ventricular drain in the brain connected with an external transducer. in particular, the study investigates how drainage influences the monitored signal: influence of flow rate, reservoir height and initial icp before draining.


Eligibility criteria:
inclusion criteria: * tbi/sah patients with need for icp monitoring exclusion criteria: -

Keywords: intracranial pressure cerebrospinal fluid drainage waveform analysis
managed access programs for ldk378, ceritinib

Conditions: Anaplastic Lymphoma Kinase (ALK)- Positive Tumors; Non-small Cell Lung Cancer (NSCLC)

Summary: the purpose of this registration is to list managed access programs (maps) related to ldk378, ceritinib.

cldk378a2401 - no longer available - managed access program (map) to provide access to ceritinib, for alk positive tumors. cldk378a2402 - no longer available - an open-label, multi-center, expanded treatment protocol (etp) of oral ldk378 in adult patients with non-small cell lung cancer (nsclc) characterized by alk positivity. cldk378a2003m - available - managed access program (map) cohort treatment plan cldk378a2003m to provide access to ldk378 (ceritinib), for alk-positive tumor pediatric patients.

Eligibility criteria:
inclusion criteria: 1. an independent request was received from a licensed physician. 2. the patient has a serious or life-threatening disease or condition and there is no comparable or satisfactory alternative therapy available for diagnosis, monitoring, or treatment. 3. the patient is not eligible or able to enroll in a clinical trial or continue participation in such trial. 4. there is a potential patient benefit to justify the potential risk of the treatment use, and the potential risk is not unreasonable in the context of the disease or condition to be treated. 5. the patient must meet any other medical criteria established by the medical experts responsible for the product or by the health authority in the country of request (as applicable). 6. provision of the product will not interfere with the initiation, conduct, or completion of a novartis clinical trial or overall development program. 7. managed access provision is allowed per local laws/regulations.

Keywords: map manage access program ceritinib alk positive tumors non-small cell lung cancer (nsclc) anaplastic large cell lymphoma (alcl) inflammatory myofibroblastic tumour (imt), ldk378
multicenter single-blind rct of ctif versus lnf for treatment of gerd in patients requiring hiatal hernia repair

Conditions: GERD; Hiatal Hernia

Summary: this single-blind randomized control study will follow 142 subjects across 7 sites randomized on a 1:1 ratio to compare treatment efficacy and safety between tif and lnf in gerd patients with hiatal hernia undergoing hernia repair.


Eligibility criteria:
inclusion criteria: 1. 22-80 years of age 2. subjects have gerd with hiatal hernia \< 5 cm (defined as maximum ,axial height from end of the esophagus to diaphragm by any study including upper endoscopy esophagram and or at time of surgery) and hill grade iii or iv 3. pathologic reflux while off ppi based on lyon criteria by either of the following: 3.1. conclusive evidence for pathologic reflux defined as acid exposure time (aet) \> 6% (worst day) or la grade c or d esophagitis. 3.2. borderline evidence of pathologic reflux defined as presence of one of the following parameters: aet 4-6%, la grade a or b. 4. commitment to long-term study 5. ability to give consent individually or by a legally authorized representative exclusion criteria: 1. hiatal hernia \> 5 cm (defined as maximum axial height from end of the esophagus to diaphragm by any study including upper endoscopy esophagram and or at time of surgery) 2. evidence of clinically significant major esophageal motility disorder as determined by the site primary investigator 3. pregnancy (in females) at time of procedure 4. previous anti-reflux procedure 5. subjects requiring mesh treatment at time of procedure 6. at the discretion of the site pi for subject safety 7. bmi \> 35 at time of surgery. 8. prior gastric surgery that may affect ability to perform either procedure or affect normal gastric function (e.g. gastrectomy, gastric bypass, sleeve gastrectomy, pyloroplasty. 9. severe gastroparesis
a study evaluating the effectiveness of amg 334 injection in preventing migraines in adults having failed other therapies

Conditions: Episodic Migraine

Summary: the purpose of this study is to determine if amg 334 is effective in treating migraines in patients who have failed other preventive migraine treatments.

this study was a double blind, placebo-controlled, randomized trial in adult patients with episodic migraine. there was a screening period of 2 weeks to assess initial eligibility, and a 4-week baseline period. after randomization, participants entered the double-blind treatment epoch (dbte) and had clinic visits for 12 weeks. all participants who completed the dbte were eligible to enter the open-label treatment epoch (olte) for up to 156 weeks. all participants had a 12 week follow-up epoch and a a follow-up visit 16 weeks after the last dose of amg334 unless the participant continued on commercially available amg334. participants who had demonstrated clinical benefit were eligible to enter a post trial access (pta-open label treatment epoch) of flexible duration for approximately 6 months.

Eligibility criteria:
inclusion criteria: * documented history of migraine in the 12 months prior to screen * 4-14 days per month of migraine symptoms * \>=80% diary compliance during the baseline period * failure of previous migraine prophylactic treatments exclusion criteria: * \>50 years old at migraine onset * pregnant or nursing * history of cluster or hemiplegic headache * evidence of seizure or psychiatric disorder * score of over 19 on beck depression inventory-2 * active chronic pain syndrome * cardiac or hepatic disease

Keywords: migraine attack headache episodic aura amg 334 cgrp receptor agonist erenumab adult