Kornimate/medical-research-clean huggingface dataset:
computer-assisted self-interviews and health screening in the pediatric emergency department

Conditions: Gonorrhea; Chlamydia

Summary: the purpose of this study is to determine if an audio-enhanced computer-assisted self-interview (acasi) will lead to increase testing for sexually transmitted infections in youth visiting a pediatric ed

the purpose of this study is to see if computer based health surveys for teenagers and young adults in the emergency department can improve the care we give, even for things that are not related to why they came to the emergency department. topics that are important in this age range include depression, violence, sexual behavior, physical activity and nutrition, though we are not asking about all of these. what will happen during this study? we wish to respect the privacy of everyone takes this survey. in order to do this, we are asking all relatives including your parents or guardians to respect several things so that you may participate: * we cannot tell family or friends the exact questions on the survey * you must be given complete privacy to answer the questions * the answers will only be shown to the healthcare team taking care of them today and the people running the study - family members will not be shown the answers * family and friends will not pressure you to discuss the survey or their answers after you are done * you will be given privacy to discuss their answers with the healthcare team if you do not feel your friends and family can respect these requests, then you cannot take the survey and cannot enroll in the study. if you agree to these requests, we will use a private area and allow you to use a computer to do the following: * explain in more detail what types of questions we will ask and why they are important * tell you how we will use your answers to improve their health care * give you a chance to answer any questions you have about the study * answer a series of questions about yourself and your health you are allowed to skip any questions you do not want to answer and can stop at any time. after you have completed the survey, a summary of your answers will become part of your medical record from today and be shown to the doctors and nurses taking care of you today. most participants will be asked to review their answers in private with the doctors and nurses taking care of them. if you do, your family and friends will be asked to step out of the room while you review the answers with the doctors and nurses. some participants may have additional testing or services done as part of their visit today based on their answers

Eligibility criteria:
inclusion criteria: * patient in the st. louis children's hospital emergency department * 15-21 years old exclusion criteria: * evaluation of abuse or sexual assault * activation of the trauma system, * level 1 or 2 triage scores (highest severity) * disabilities preventing independent computer use * psychiatric chief complaints * inability to speak english

Keywords: acasi gonorrhea chlamydia emergency department youth adolescents computer questionnaire
the effect of pain neuroscience education and behavioural graded activity on chronic pain in breast cancer survivors

Conditions: Breast Neoplasms; Survivors; Chronic Pain

Summary: chronic pain in breast cancer survivors (bcs) is of considerable concern as it impacts the health-related quality of life (hrqol) and activities of daily living negatively. over the past decades, awareness has raised the value of pain neuroscience education (pne) in chronic pain. however, pain education remains underused in oncology and is often restricted to a biomedical management, which falls short in explaining persistent pain following cancer. since pne alone has rather small effect sizes, it should ideally be combined with a physical part, 'behavioural graded activity' (bga). therefore, the purpose of this study is to investigate the effectiveness of pne with bga compared to usual care on chronic pain in bcs. a multi-centre, parallel, two-arm, double-blinded superiority with a three months intervention and two years follow-up will be conducted in 200 bcs with chronic pain. these will be randomly assigned to the intervention or usual care group. the intervention group will receive 6 sessions, in which pne and bga will be integrated. whereas, the usual care group will receive an information leaflet regarding "pain in and after cancer". the primary objective of the present study is to examine whether the combination of pne and bga has an added value in decreasing the pain intensity compared to the usual care in bcs with chronic pain. the secondary objectives are to investigate whether the combination of pne and bga has the ability to reduce endogenous hyperalgesia and improve hrqol compared to the usual care in bcs with chronic pain.


Eligibility criteria:
inclusion criteria: * to meet the definition introduced by the national cancer institute's office of cancer survivorship, in which a cancer survivor is a patient with a history of cancer that is beyond the acute diagnosis and treatment phase. patients need to be cancer-free and should have finished their primary treatment with a curative intent for at least 3 months prior to study participation. adjuvant hormonal therapy and immunotherapy form the exception to the rule and are tolerated. * to report a pain severity of at least 3 out of 10 on pain visual analogue scale. * to be able to speak and read in dutch in order to give informed consent and to complete the assessment tools. written and signed consent will be obtained from all participants. exclusion criteria: * suffering from dementia or cognitive impairment (unable to understand the test instructions and/or mini mental state examination score \<23/30). * suffering from severe psychological or psychiatric diseases. * diagnosis of new neoplasms or metastases.

Keywords: behavioural graded activity pain neuroscience education
exploration and determination of genomic markers predictive of uterine atony

Conditions: Uterine Atony

Summary: the primary objective of this study is to determine whether there are markers in the tissue of atonic uteri, and in the patients' plasma that would help identify patients likely to suffer postpartum hemorrhage due to uterine atony. we also will attempt to identify the cause(s) of uterine atony that might suggest mechanisms to prevent and manage it.

patient will be recruited from those admitted to our labor and delivery unit. ten women will be the control subjects, and these will be selected from patients who are admitted for scheduled cesarean delivery. ten women will be selected from women who develop uterine atony either following cesarean delivery, or postpartum patients who delivered vaginally but subsequently required surgical management of uterine atony (hysterectomy or uterine saving surgery). from each patient a small amount of uterine muscle will be excised and placed in a fixative, preservative transport medium. ten cubic centimeters of blood will be drawn from each patient to accompany the tissue. the tissue and blood will be processed and analyzed to identify differences in the tissue and plasma of messenger rna, micro rna, long non-coding rna, and dna methylation in normal and atonic uterine patients. statistical analysis of these markers will be performed to determine whether there are significant differences in their expression. it is hoped that differences will be discovered that may be used diagnostically to predict uterine atony, and differences that may suggest the etiology of uterine atony.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * female * pregnancy over 23 weeks gestation exclusion criteria: * under 18 years of age * prisoners * non-female sex * cannot provide informed consent

Keywords: genomic markers
depression prevention program for adolescents

Conditions: Depression

Summary: this study will compare the effectiveness of two programs designed to prevent depression in adolescents.

major depression is one of the most common psychiatric disorders in adolescents. in many cases, the condition is recurrent and can result in serious psychological impairment. a high number of depressed adolescents never receive treatment; therefore, it is crucial to develop prevention programs for this disorder that are effective and can be easily disseminated. this study will evaluate and compare the effectiveness of cognitive behavior therapy (cbt) and supportive/expressive (s/e) therapy in preventing depressive symptoms in adolescents. this study will last 2 years. participants will be randomly assigned to receive six sessions of cbt, s/e therapy, or standard depression education over 2 years. the cbt intervention will focus on reducing negative thoughts and increasing engagement in pleasant activities. s/e therapy is designed to allow adolescents to express their negative emotions and talk about recent stressful events in a supportive environment of their peers. surveys and psychiatric interviews will be completed by all participants and their parents at the beginning and the end of the study. the surveys and interviews will assess depressive symptoms.

Eligibility criteria:
inclusion criteria: * beck depression inventory score higher than 10 * parent or guardian willing to provide informed consent exclusion criteria: * diagnosis of depression

Keywords: adolescent cbt
uremic toxins and outcomes in chronic kidney disease

Conditions: Chronic Kidney Diseases

Summary: the aim of this cohort study is: to investigate the etiology and epidemiology of comorbidities in ckd; to find out risk factors associated with the mortality of ckd; to find out uremic toxins which are related to the mortality and comorbidities of ckd; to focuse on the association between uremic toxins and inflammation, oxidative stress and nutritional status in ckd.

to investigate the etiology and epidemiology of comorbidities in ckd; to find out risk factors associated with the mortality of ckd; to find out uremic toxins which are related to the mortality and comorbidities of ckd; to focuse on the association between uremic toxins and inflammation, oxidative stress and nutritional status in ckd.

Eligibility criteria:
inclusion criteria: * age ≥18 years old; * clinically diagnosed with chronic kidney disease, according k/doqi criteria. exclusion criteria: * acute kidney injury * history of kidney injury \<3 months * malignancy * pregnancy * incomplete clinical data

Keywords: chronic kidney disease uremic toxin prognosis
evaluation of pacemaker algorithms to avoid unnecessary right ventricular pacing

Conditions: Pacemaker Implantation for Sinus Node Disease

Summary: unnecessary right ventricular pacing has been shown to be detrimental in recipients of implantable pacemaker or defibrillators. the advantage study evaluates the efficacy of two pacemaker based algorithms (atrioventricular hysteresis function versus mode switch to atrial pacing) to reduce right ventricular pacing.

comparison of the effect of an atrioventricular hysteresis function with a mode switch to atrial pacing on the right ventricular pacing percentage in a multi-centre, prospective, randomized, single blinded, cross-over study.

Eligibility criteria:
inclusion criteria: indication for the implantation of a dual-chamber pacemaker exclusion criteria: persistent or permanent atrial tachyarrhythmias atrioventricular block 2nd or 3rd degree indication or the implantation of an defibrillator
the evaluation of the diagnostic properties of intra-operative in-situ thyroglobin levels of cervical lymph nodes, in the discrimination between benign and malignant lymph nodes in thyroid cancer: a prospective multicentre study.

Conditions: Thyroid Cancer

Summary: cytological examination of punctured lymph nodes is the gold standard for confirming metastatic lymph node spread of differentiated thyroid cancers. in order to increase the diagnostic sensitivity of fine-needle cyto-punctured lymph nodes, an assessment of tg levels of the aspirate could be included. although this technique has been well proven, many uncertainties remain, especially with regards to a pathological cut-off value and its clinical utility when the thyroid is still intact. this uncertainty is mainly due to discordancy between low tg levels found in cytopunctured lymph nodes with normal cytology, and their final histopathological analyses. to eliminate this uncertainty, cyto-punction will be performed intra-operatively after localizing and isolating the target lymph nodes for assessment of cytology and tg values. the thyroid gland might be present or absent (already operated) depending on the case. finally, the cyto-punctured lymph nodes will be excised for complete histopathological analysis. in order to determine whether the tg values are appropriate in cases where the thyroid is intact, a control group has been included (first operation for thyroid cancer or benign pathology). to eliminate the possible iatrogenic risks of lymph node dissection and resection in patients for whom it is not indicated, only lymph nodes found along the incision path for neuromonitoring of the recurrent laryngeal nerve (performed systematically) will be analysed and excised.


Eligibility criteria:
inclusion criteria: * subject aged 18 years and above, male or female, with a valid social security coverage; * subject willing to participate in the study with a signed informed consent; * subject being operated for a papillary thyroid cancer, re-operated for persistent/relapsed lymphadenopathy, or for benign thyroid pathology (graves disease, multinodular goitre, toxic nodule); * subject having had a blood test for plasma tg levels and circulating anti-tg antibodies in the week preceding the surgical intervention. exclusion criteria: - subjects presenting with thyroid cancers of non follicular origin

Keywords: follicular origin
observational study of outcomes after echomark and echosure-based free flap monitoring

Conditions: Free Flap Transfer; Malignant Neoplasm

Summary: the purpose of this study is to evaluate the performance of the echomark and echosure as an ultrasound-based method of monitoring the viability of free flaps and patency of at-risk vessels.


Eligibility criteria:
inclusion criteria: * age \> 18 years * patients presenting for microvascular tissue transfer procedures where the surgeon has selected echomark and echosure as the optimal method of vascular monitoring based on clinical assessment and plan * patient is able to sign informed consent and able to participate in all testing associated with this clinical investigation * women of childbearing potential have a negative pregnancy test exclusion criteria: * age \<18 years old * patient unable to sign informed consent * patient participating in another investigational device or pharmacological study * prisoner or patient from vulnerable populations as defined in 45 cfr 46.
assessment of the efficacy of chatgpt in detecting surgical site infections following elective colorectal surgery

Conditions: Surgical Site Infection

Summary: epidemiological surveillance is one of the eight core components of the world health organization infection prevention and control programmes. these include surveillance programmes for surgical site infection (ssi). at present, for ssi surveillance, infection control teams perform a manual time-consuming work, which could make a transition to automated surveillance leveraging the new information technology. this study aimed to evaluate the ability of chatgpt-4o to detect surgical site infection at the three anatomical levels.

healthcare-associated infections (hais) have a negative impact on patient health, represent a significant healthcare and economic burden on healthcare systems and are considered the most preventable cause of serious adverse events in hospitalised patients. epidemiological surveillance is one of the eight core components of the world health organization (who) infection prevention and control programmes. these include surveillance programmes for surgical site infection (ssi), which have proven to be effective in all types of surgery and in a variety of settings. for a programme to be effective, surveillance for hcais must be active, prospective and continuous, comprising a surveillance period up to 30-90 days post-intervention, to cover the high rate of ssis detected after discharge. at present, infection control teams perform a manual, prospective, time-consuming and almost artisanal work, which should make a transition to automated or semi-automated surveillance that leverages the possibilities offered by today's information technology. the evolution of surveillance systems should benefit from this new possibilities offered by artificial intelligence, allowing automated detection of suspected ssi adverse events from clinical course text, microbiology reports or coding of diagnoses, procedures, complications and readmissions. this pilot study aims to evaluate the ability of chatgpt to detect surgical site infections (ssi) at the three anatomical levels described by the cdc. the aim is to retrospectively compare the results of the ai chatbot in diagnosing ssi, trained using the us cdc definition criteria, with a cohort of elective colorectal surgery patients evaluated through a nationwide nosocomial infection surveillance system.

Eligibility criteria:
inclusion criteria: * elective colorectal resection exclusion criteria: * emergency surgery * infection present at operation * previous intestinal stoma

Keywords: surgical site infection surveillance artificial intelligence chatgpt natural language processing
checklist tool in engaging patients in the discharge planning process

Conditions: Hospitalization; Malignant Neoplasm; Transitional Care Planning

Summary: this clinical trial studies how well a checklist tool works in engaging patients in the discharge planning process. engaging patients in the discharge process may increase participation in the discharge process and improve discharge outcomes, understanding of care after hospitalization, and decrease complications.

primary objectives: i. measure the impact on discharge and transition satisfaction of utilizing questions from the consumer assessment of healthcare providers and systems (chaps) patient satisfaction survey. ii. measure the impact of the tool to engage patients in discharge (tepid) on patient's readiness for hospital discharge and problems after discharge questionnaire-english (padq-e) results. iii. measure the impact on decreasing healthcare utilization measures: readmission rates within 30 days from hospital discharge, hospital length of stay of admission in hospital, and emergency department visits within 30 days of hospital discharge. outline: patients complete the tepid checklist of items during hospital stay. after completion of the study, patients are followed up for 35 days.

Eligibility criteria:
inclusion criteria: * patients fluent in english, conscious, coherent, and alert or have an adult caregiver present that is fluent in english will be identified for the tepid research project exclusion criteria: * patients discharged to another inpatient facility (hospice, skilled nursing facility, long term acute care hospital \[ltach\], or acute rehab) or patients discharged home with hospice will be excluded * any patients that are transferred to another unit prior to discharge will be excluded
high frequency chest wall oscillation and cystic fibrosis

Conditions: Cystic Fibrosis

Summary: high frequency chest wall oscillation (hfcwo) has been shown to increase tracheal mucus clearance compared with a control group. these observations led to the development of the vest® which is a non-stretchable jacket connected to an air-pulse generator and worn by the patient over the chest wall. the generator rapidly inflates and deflates the vest®, which gently compresses and releases the chest wall between 5 and 20 times per second. this generates mini-coughs that are said to dislodge mucus from the bronchial walls and to facilitate its movement up the airways. the vest® has been shown to reduce the viscosity of mucus and this should further enhance mucus clearance. people with cystic fibrosis (cf), admitted to hospital with an acute infective pulmonary exacerbation, should increase the frequency and duration of their airway clearance sessions owing to the increase in quantity and viscosity of purulent bronchial secretions.in the united kingdom, and in many other countries, the availability of physiotherapists to assist with the recommended number of daily treatments is insufficient to meet patient need. if the use of high frequency chest wall oscillation, in addition to 'usual' self airway clearance techniques, in the early morning and evening was to facilitate recovery from an exacerbation, this would indicate an important place for high frequency chest wall oscillation in the management of people with cystic fibrosis. hypothesis: the addition of high frequency chest wall oscillation to twice daily supervised physiotherapy is as effective as the addition of self treatment in facilitating recovery from an acute infective pulmonary exacerbation, as measured by improvement in lung function, specifically forced expiratory volume in one second (fev1).


Eligibility criteria:
inclusion criteria: * diagnosis of cystic fibrosis * hospitalised patients admitted with a pulmonary infection * forced expiratory volume in one second (fev1)of 15% predicted or over * 16 years of age or over exclusion criteria: * current severe haemoptysis * rib fractures or history of spontaneous rib fractures * pregnancy * lung abscess * end stage disease * requiring more than two assisted treatment sessions per day * requiring treatment with positive pressure * inability to give consent

Keywords: airway clearance cystic fibrosis high frequency chest wall oscillation
effects of the sangvia blood collection system on postoperative infections in orthopedic patients

Conditions: Coxarthrosis

Summary: the purpose of this study is to compare the infection rate in patients receiving/not receiving their own blood, collected during surgery, during and after orthopedic surgery. the hypothesis is that transfusion of autologous salvaged blood may reduce postoperative infection.

postoperative infections (both systemic and wound infections) are complications that should be avoided both due to the discomfort and the risk to the patients and for the corresponding increment of hospital costs. there are some studies indicating that transfusion of autologous salvaged blood may reduce postoperative infections. this may be due to immunostimulating cytokines released in these products. however, as these cytokines also may cause adverse events as febrile transfusion reactions and activation of the complement and the coagulation cascades, the overall impact may be different. there are two publications from an austrian group indicating that allogeneic blood transfusion in orthopedic patients cause increased postoperative infection rate irrespectively of the leukocyte content of the red cell concentrates. the austrian studies were not randomized. therefore, it would be useful to perform a randomized, prospective study where the patients receive transfusion of salvaged blood versus allogeneic red cell concentrate as their primary replacement product, respectively. the purpose of the pilot study is to evaluate if transfusion of autologous salvaged blood reduces the infection rate in orthopedic patients compared with patients receiving allogeneic blood transfusion. the study is limited to one source of autologous blood; blood collected by the sangvia blood collection system, and the study is partially sponsored by the manufacturer.

Eligibility criteria:
inclusion criteria: * patients with a risk of needing red cell transfusion after surgery estimated to be above 75%, judged by preoperative hemoglobin concentration and known risk of preoperative bleeding * patients over 16 years of age * patients who have consented to participate exclusion criteria: * patients with a known hemolytic anemia (congenital or acquired) * patients for whom informed consent has not been obtained

Keywords: autologous blood transfusion allogeneic blood transfusion infection rate