Kornimate/medical-research-clean huggingface dataset:
effects of feet mechanical stimulation on cardiovascular autonomic profile and inflammation in parkinson's disease

Conditions: Parkinson's Disease; Autonomic Neuropathy; Inflammation; Hypertension

Summary: in the present study, investigators test the hypothesis that a controlled mechanical pressure applied on specific sites of both fore-feet (es) can reduce the inflammatory state and arterial blood pressure in patients with parkinson's disease by increasing the overall parasympathetic activity and reducing vascular sympathetic modulation.

neuroinflammation may contribute to the cascade of events leading to neuronal loss in parkinson's disease (pd) thus facilitating motor and autonomic impairment. a link between autonomic function and chronic and acute inflammation has been previously described. specifically, active inflammatory state was associated with an overall increased sympathetic tone, whereas the parasympathetic cholinergic activation seemed to promote a decrease of inflammatory compounds in inflamed tissues. in addition, a functional link between peripheral sensory afferents and autonomic control has been reported. in a recent study it was observed that in pd patients a somatosensory activation by mechanical stimulation of specific sites of the fore-foot (effective stimulus, es), improved gait, increased cardiac vagal modulation and decreased vascular sympathetic activity at rest. this latter effect was associated with a decline in arterial blood pressure values. the present study is aimed at: * addressing the magnitude of the inflammatory state in pd patients. * testing the hypothesis that a change in the autonomic profile of pd patients induced by es, consistent with cardiovascular increased parasympathetic and decreased sympathetic activities, may promote an overall reduction of the pd inflammatory state.

Eligibility criteria:
inclusion criteria: * idiopathic pd characterized by a moderate/important motor impairment (hoehn\&yhar scale 2-4) * pd will be diagnosed according to the united kingdom (uk) parkinson's disease society brain bank criteria, (or on the basis of clinical criteria, dopamine transporter (dat)- scan and/or mri). exclusion criteria: * dysautonomias and other neurodegenerative diseases * history/familiarity with seizures * atrial fibrillation and other relevant cardiac rhythm disturbances * chronic inflammatory diseases and chronic use on anti-inflammatory drugs * diabetes * other neurological or psychiatric diseases * pacemakers or other electronic implants inserted into the body * coronary disorders, elevated intracranial blood pressure * assumption of drugs facilitating seizures, psychiatric drugs, alcohol abuse

Keywords: foot mechanical stimulation autonomic nervous system inflammation parkinson's disease spectral analysis heart rate variability blood pressure variability
accelerating lung cancer diagnosis through liquid biopsy

Conditions: Non-small Cell Lung Cancer

Summary: this study will assess the utility of liquid biopsy to accelerate the time to treatment for patients with newly diagnosed advanced non-small cell lung cancer, compared to the conventional diagnostic pathway of molecular testing of tumour tissue after imaging and biopsy.


Eligibility criteria:
inclusion criteria: 1. lung ramp multidisciplinary cancer conference or study team confirms radiologic (clinical) evidence of advanced, unresectable lung cancer; 2. measurable disease (presumed malignant) by recist 1.1; 3. age ≥18 years; 4. ability to provide written informed consent; 5. diagnostic biopsy and molecular profiling ordered or planned. patients remain eligible even if biopsy or tumour testing later fails or is deemed not feasible. exclusion criteria: 1. pregnancy; 2. concurrent active malignancy except for localized non-melanomatous skin cancer or non-invasive cervical cancer. any previous cancer (excluding nsclc) must have been treated more than 2 years prior to study entry with no current evidence of active disease.
a study in healthy volunteers to estimate the pharmacokinetics of four modified-release formulations of dimebon (latrepirdine)

Conditions: Alzheimer's Disease; Huntington Disease

Summary: this study will evaluate four different modified release formulation to estimate the amount of dimebon available to the body relative to the current dimebon formulation that is given three times a day. the results of this study will help inform and guide further formulation development efforts with the ultimate goal of reducing dose frequency to once-a-day or twice-a-day.


Eligibility criteria:
inclusion criteria: * healthy male and/or female subjects between the ages of 18 and 55 years, inclusive. body mass index (bmi) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lbs). exclusion criteria: * evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing). * subjects with any history of a previous seizure (including childhood febrile seizures) or convulsion or significant head trauma. * subjects with hypersensitivity reactions to dimebon or other antihistamines. * any condition possibly affecting drug absorption (eg, gastrectomy). * smokers who use greater than 5 cigarettes per day. * use of proton pump inhibitors, antacids, and h2-blockers are prohibited for the duration of the study. * pregnant or nursing females; females of childbearing potential who are unwilling or unable to use an acceptable method of non-hormonal contraception.

Keywords: bioavailability pharmacokinetics alzheimer's disease huntington disease
modulated accelerated radiotherapy in early breast cancer

Conditions: Breast Cancer; Radiation Toxicity

Summary: this trial was a retrospective study on postoperative accelerated hypofractionated imrt (mara-1) in patients with early stage breast carcinoma, to compare late toxicity after this treatment and standard fractionated rt delivered with 3d-crt.

the aim of this study was to evaluate the clinical results in terms of late skin and subcutaneous toxicity of accelerated hypofractionated forward-planned imrt in patients with early stage bc. results were compared with a historical control group (cg) of patients treated with 3d-conformal postoperative rt delivered with conventional fractionation.

Eligibility criteria:
inclusion criteria: * confirmed histologic evidence of ptis-pt3 breast cancer * breast conservative surgery * post menopausal status * clear surgical margin exclusion criteria: * pt4 * positive or close resection margins * 3 or more metastatic axillary nodes * nodal irradiation * m1

Keywords: breast cancer radiotherapy cutaneous toxicity subcutaneous toxicity imrt
prolonged vasospasm in subarachnoid hemorrhage

Conditions: Subarachnoid Hemorrhage; Vasospasm, Intracranial

Summary: the prevalence and clinical implications of prolonged cerebral vasospasm in patients with subarachnoid hemorrhage are unknown.

the prevalence and clinical importance of prolonged cerebral vasospasm (after day 21 of bleeding) in patients with subarachnoid hemorrhage is unknown. objectives: to determine the prevalence and clinical relevance of prolonged vasospasm in patients with subarachnoid hemorrhage secondary to cerebral aneurysm. a prospective and observational study was conducted. adult patients with a diagnosis of subarcnoid hemorrhage ct scan or presence of blood in the cerebrospinal fluid were incorporated. patients with vasospasm were followed daily with transcranial doppler. those with technical impossibility to perform transcranial and pregnant doppler were excluded. day 0 was defined, the day of the last bleeding. evaluation: 1) it was considered in patients with prolonged vasospasm: whether or not it was associated with clinical manifestation (deterioration of the sensory or new neurological deficit) and 2) the magnitude of the vasospasm (mild, moderate or severe) was measured by transcranial doppler.

Eligibility criteria:
inclusion criteria: subarachnoid hemorrhage - exclusion criteria: pregnancy -

Keywords: subarachnoid hemorrhage vasospasm, intracranial transcranial doppler
a study of patupilone in patients with advanced solid tumors and varying degrees of hepatic function

Conditions: Advanced Malignancies; Tumors

Summary: this phase i study will determine the pharmacokinetic profile of patupilone in patients with mild or moderately impaired hepatic function within 2 cycles of treatment. the study population for this trial consists of patients with a documented advanced solid tumor. patients will be stratified into 3 groups: those with normal liver function, and those with mild or moderate liver dysfunction.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * world health organization (who) performance status score of: 0 - you are fully active and more or less as you were before your illness; 1 - you cannot carry out heavy physical work, but can do anything else; or 2 - you are up and about more than half the day, you can look after yourself, but are not well enough to work. * life expectancy of 3 months or more * patients with measurable or evaluable disease who have histologically documented advanced solid tumor and who have progressed after systemic therapy or for whom standard systemic therapy does not exist exclusion criteria: * severe and/or uncontrolled medical disease * known diagnosis of human immunodeficiency virus (hiv) infection * presence of any other active or suspected acute or chronic uncontrolled infection * severe cardiac insufficiency, with uncontrolled and/or unstable cardiac or coronary artery disease * history of another malignancy within 5 years prior to study entry, except for curatively treated non-melanotic skin cancer or cervical cancer in situ other protocol-defined inclusion/exclusion criteria may apply.

Keywords: epo patupilone solid tumors
new diabetes mellitus and pre-diabetes with first-time diagnosed coronary artery disease

Conditions: PreDiabetes; Diabetes; Coronary Artery Disease

Summary: a prospective analytic study to evaluate the incidence, clinical and laboratory characteristics, extent of coronary artery disease and short-term outcome of newly diagnosed diabetes and pre-diabetes in patients with first-time diagnosed coronary artery disease treated in saud al babtain cardiac center.


Eligibility criteria:
inclusion criteria: * first time diagnosed coronary artery disease as confirmed by invasive coronary angiography * emergently or electively admitted as coronary artery disease patients. * informed consent form exclusion criteria: * prior diagnosis of diabetes or pre-diabetes based on the diagnostic criteria of the american diabetes association (ada, 2020) * known coronary artery disease
effects of different inhalation oxygen concentrations on postoperative atelectasis

Conditions: Atelectasis

Summary: this study was a single-center, prospective, randomized controlled, two-arm study. this study will be conducted in the first hospital of china medical university. the investigators aimed to investigate the effects of different inspired oxygen concentrations in lung protective ventilation strategies on immediate postoperative atelectasis and intraoperative changes of oxygenation index in patients undergoing neurosurgical surgery in the supine position.

this study was a single-center, prospective, randomized controlled, two-arm study. this study will be conducted in the first hospital of china medical university. the investigators aimed to investigate the effects of different inspired oxygen concentrations in lung protective ventilation strategies on immediate postoperative atelectasis and intraoperative changes of oxygenation index in patients undergoing neurosurgical surgery in the supine position. a total of 96 neurosurgical patients under supine position were selected with an estimated operation time of more than 2 hours. patients were randomly assigned to low-oxygen concentration (30%fio2) l group, or high-oxygen concentration (60%fio2) h group, and both groups received lung protective ventilation strategies. the main outcome was the comparison of postoperative atelectasis volume between the two groups. secondary outcomes were the comparison of intraoperative oxygenation index and postoperative changes in diaphragm height between the two groups.

Eligibility criteria:
inclusion criteria: * patients with american society of anesthesiologist (asa) physical status i-ii; * older than 18 years; patients with operation time more than 2 hours and plan to extubate in the operating room; * preoperative blood gas partial pressure of oxygen was more than 80mmhg; * patients scheduled for elective neurosurgery were operated in the supine position. exclusion criteria: * a history of acute lung injury with acute respiratory distress syndrome within three months; * heart failure (new york heart association class) greater than iv, severe liver and kidney dysfunction (child b or c liver failure, glomerular filtration rate \<30ml/min); * bmi \> 30 kg/m2. * the operation time is more than 10 hours; * the amount of bleeding was more than 500ml; the total fluid volume exceeded 3000ml.
effects of vitamin e supplementation on free radicals and fat level of obese adolescence in jakarta, indonesia

Conditions: Obesity, Adolescent; Oxidative Stress

Summary: this study evaluate supplementation of vitamin e (alpha-tocopherol) in obese adolescent. half of the patient will receive vitamin e and the other half received placebo

one of obesity treatments that play important role is antioxidant diet. the effects of vitamin e supplementation as an antioxidant treatment in obese adolescent have not been concluded yet in indonesia. the primary aim of this study is to observe oxidative stress biomarker (isoprostane) in obese teenagers who consume vitamin e for 2 months. the secondary aim is to observe their body mass index and lipid profile after supplementation the study is randomized, double blind, placebo controlled trial in design and employed a consecutive sampling technique to sample subjects of 70 obese adolescent age 14 - 18 in senior high schools jakarta. blood tests of lipid profile (total cholesterol, hdl, ldl, triglyceride), fasting blood glucose, liver function (ast,alt) and oxidative stress biomarker (isoprostane) were taken for every subject after done fasting for 12 hours. this study is a randomized allocation and double blind technique. subjects divided into two groups, which one group receiving treatment of vitamin e and other group receiving placebo. the dose and duration of vitamin e treatment is 400 iu per day for 2 months. at the end of treatment, all subjects had to run the same medical interview, physical examination and blood test.

Eligibility criteria:
inclusion criteria: * obesity bmi ≥ p95 (cdc growth curve) exclusion criteria: * consuming antioxidants drug regularly within recruiting time * consuming orlistat
clinical and economic impact of an organized treatment pathway on afib patient management from the er

Conditions: Cardiac Arrhythmia; Atrial Fibrillation

Summary: investigators developed a multidimensional protocol for the management of af in the emergency department. investigators aimed to assess if this new er af management protocol would result in better outcomes compared to routine care.

management variation such as selecting rate vs rhythm control, timing and need for thromboembolic treatment, er vs inpatient treatment and cardiology consultation could lead to disparate care of patients. therefore, there is a need for future studies to standardize practice leading to improved management, decreased rates of hospitalization and overall cost. investigators developed a multidimensional protocol for the management of af in the emergency department. investigators aimed to assess if this new er af management protocol would result in better outcomes compared to routine care.

Eligibility criteria:
inclusion criteria: * consecutive patients \> 18 years of age who comes to the er with af as the primary diagnosis and is treated according to study protocol. exclusion criteria: * patients with established cardiology or electrophysiology care.

Keywords: clinical and economical impact treatment pathway emergency room atrial fibrillation
muscle function after childbirth

Conditions: Postpartum; Muscle Fatigue; Force Steadiness; Nulligravid; Muscle Weakness

Summary: this study will evaluate lower extremity and trunk neuromuscular control in 78 nulligravid and postpartum women. participants will attend two experimental sessions, approximately 1 week apart, to assess neuromuscular function. physical activity levels will also be assessed.

stability of the lumbar spine and pelvis is essential to nearly all activities of daily living, and is achieved primarily by muscular stabilization. recent studies have shown that postpartum women are more fatigable than nulligravid women during fatiguing tasks with the lumbopelvic stabilizing muscles (23%) and the trunk flexor muscles (52%) at six months postpartum. postpartum women also demonstrate impaired control of force with the trunk flexor muscles; however, it is unknown if force control during a fatiguing task of the lumbopelvic stabilizing muscles is impaired in postpartum women. this study has 3 purposes: (1) to quantify limb steadiness during fatiguing exercise of the lumbopelvic stabilizing muscles among nulligravid women and postpartum women; (2) to quantify muscle activity in the trunk, test limb and contralateral limb to provide insight into motor control; and (3) to identify possible factors (inter-recti distance (ird), physical activity, pain, biopsychosocial factors) that contribute to neuromuscular function (fatigability and force control). this is a novel, translational study that, for the first time, will quantify lower extremity force control in postpartum women. as this has not been studied before, to the best of the investigators' knowledge, this proposal will be a pilot study to establish means to utilize in power analyses for future studies of larger magnitude. furthermore, neuromuscular function is not typically assessed clinically in postpartum women, and no tests exist to easily assess fatigability of the lumbopelvic stabilizing muscles in clinic settings. this study will also provide further data to highlight the aslr fatigue task as a possible clinical examination tool and outcome measure to assess fatigability of the lumbopelvic stabilizing muscles.

Eligibility criteria:
inclusion criteria: * post-partum * primiparous (this is their first child) exclusion criteria: * multiple gestation * prescription anti-inflammatory/pain medications that are taken daily * significant orthopedic conditions that would contraindicate performance of the fatigue task (such as fractures, severe scoliosis, etc) * cardiovascular \& pulmonary disease * neuromuscular health conditions (such as diabetes, neuropathy, multiple sclerosis, stroke, seizures, etc) * history of previous abdominal surgery (with the exception of cesarean delivery) nulligravid women (controls) * women from the surrounding community will also be recruited to serve as controls * nulligravid women will meet the same inclusion/exclusion criteria as the postpartum women, with the exception of never having been pregnant
lorraine registry of multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the relsep aims to register exhaustively every new case of multiple sclerosis (ms) occuring in lorraine a french region, and follow up on them for an indefinite duration, registering disease evolution and intercurrent events.

as every patient registry in france, the relsep is periodically (every four years) evaluated by an independent committee. the relsep interrogate multiple sources to insure its exhaustiveness : * every neurologists of lorraine * ms patient network in lorraine * health insurance data * pmsi (administrative french national database for hospitals) * biological and imagery services in lorraine procedures (automatic and manual) are used to eliminate duplicates once a patient has been identified its medical file are checked by investigators in order to retrieve the relevant information. new ms cases are confirmed by neurologists. automatics (implemented in edmus software)and manual checks are implemented in the registry database, looking for inconsistencies. the following data are registered : * name, birthname * sex * date of birth * location (town) * birth location (town) * profession * number of siblings * marital status * number of children * date of onset * date and nature of clinical manifestations * mri reports * csf analysis reports * event-related potential reports * impairment and disability evolution * treatments (start and change of drug treatment) * drugs related events * cause of treatment discontinuation * disease progression every case has a follow up at least every two years. the quality of data is evaluated by periodically auditing cases at random from our database. an annual report on the main data (incidence and prevalence) of ms in lorraine is produced. data are also used for observational studies on prognostic factors.

Eligibility criteria:
inclusion criteria: * having a confirmed multiple sclerosis diagnosis * living in lorraine (french region) exclusion criteria: * refusal to be registered
fast titration of oral appliance at obstructive sleep apnea syndrome (osas) treatment

Conditions: Obstructive Sleep Apnea Syndrome

Summary: the literature does not discuss if the fast oral appliance titration (30 days period) in obstructive sleep apnea syndrome (osas) treatment, may improve subjects quality of life in such brief period. temporomandibular dysfunction-related (tmd) is one of the most important side effects observed in osas treatment with oral appliance. since the effectiveness of mandibular exercises in the control of tmd pain has already been verified, it may play a fundamental role in the support of the fast oral appliance titration.


Eligibility criteria:
inclusion criteria: * bmi ≤ 35kg/m2 * mild to moderate osas diagnosis according to the aasm criteria (2005) * negative tmd diagnosis (according to rdc/tmd) exclusion criteria: * dental conditions that contraindicated the oral aplliance usage * sleep disorders other than osas

Keywords: mandibular advancement oral appliance tmd