Kornimate/medical-research-clean huggingface dataset:
aquatic exercise program for knee osteoarthritis

Conditions: Knee Osteoarthritis; Obesity

Summary: the aim of pico study is to design an aquatic exercise program specific for obese individuals with knee osteoarthritis which the main goals are oa symptoms management and the improvement of physical fitness. the author's opinion is that the musculoskeletal pain is the main constraint for any kind of mobility and its control should be considered as an important goal in the weight management's programs. therefore the pico project proposes an aquatic exercise program to controlling pain and other symptoms management, showing that it is possible to live with the disease, and motivating the change in lifestyle, thus preventing the installation or worsening of koa. in this way, five hypotheses were formulated: h1. 3 months of aquatic exercise is enough to improve koa symptoms and functionality in obese individuals; h2. the gait parameters of obese individuals with koa can be improved by aquatic exercise; h3. beyond the exercises skills, aquatic exercise group classes can work with an educational component, promoting lifestyles changes. h4: pain reduction and a better psychological status can lead an increase of functionally, increasing amount of physical activity. h5: even if the main goal is not weight management, the aquatic exercise program can lead a weight reduction or body composition change.

the pico program is an overall body fitness and mind intervention through aquatic exercise involving as well an education component, created specifically for individuals with koa. its a single-blinded, one center, and randomized controlled trial with 3 months duration. participants will be randomized into one of two groups: aquatic exercise (ae) and control group (cg) which will participate in an educational program with the same hourly load.

Eligibility criteria:
inclusion criteria: * the study sample will consist of 60 adults, community-dwelling (lisbon) people with: (1) age 40-65 years; (2) 28.0 ≤ bmi ≤ 45 kg/m2; unilateral or bilateral koa (3) knee pain (4) grade i-iii radiographic tibiofemoral oa or tibiofemoral plus patellofemoral oa (5) a sedentary lifestyle, defined as not participating in a program that incorporates more than 30 minutes per week of formal exercise within the past 6 months; (6) being independent with mobility capacity; and (7) reading and writing knowledge. exclusion criteria: * subjects with skin diseases, unstable medical conditions and with hip or knee replacement, knee surgery within the past 6 months and participants who had any type of knee injections within the past 3 months will be excluded of pico.

Keywords: aquatic exercise knee osteoarthritis exercise pain obesity.
comparison of tot 8/4 versus tot 6/3

Conditions: Urinary Incontinence

Summary: transobturator tapes (tot) are placed according to the surgical technique described by delorme et al. in patients with a previous cervico-sacropexy (cesa) or vagino-sacropexy (vasa). before final fixation of the tapes and suturing the vaginal skin a hegar dilator sound with either 8 mm or 6 mm diameter is placed in the urethra and a second hegar dilator sound with either 4 mm or 3 mm diameter is placed between the tape and the urethra. after suturing the vaginal skin the hegar sounds are removed.

retrospective studies demonstrated that the distance between urethra and suburethral sling can vary considerably between 1 mm and 10 mm. in order to standardize the placement of the suburethral sling we choose two different distances between urethra and sling. transobturator tape (tot) are placed according to the surgical technique described by delorme et al. in patients with a previous cervico-sacropexy (cesa) or vagino-sacropexy (vasa). before final fixation of the sling and suturing the vaginal skin a hegar dilator sound with either 8 mm or 6 mm diameter is placed in the urethra and a second hegar dilator sound with either 4 mm or 3 mm diameter is placed between the tape and the urethra. after suturing the vaginal skin the hegar sounds are removed. according to the used hegar dilator sounds two different techniques are used: tot 8/4 or tot 6/3.

Eligibility criteria:
inclusion criteria: * urinary incontinence exclusion criteria: * previous tot or tvt

Keywords: urinary incontinence, cesa, vasa, tot, tvt
effects of royal jelly supplementation in chronic kidney disease

Conditions: Kidney Failure, Chronic; Oxidative Stress; Hemodialysis

Summary: the objective of this study is to evaluate the effects of royal jelly on inflammation and cellular senescence in patients with chronic kidney disease (ckd) on hemodialysis (hd).

royal jelly is a substance produced in the hypopharyngeal glands of bees that operate young, and rich in bioactive compounds such as polyphenols, free fatty acids and exclusive peptides capable of mitigating inflammation and premature aging (genomic instability, mitochondrial dysfunction, shortening of telomeres) existing in patients with chronic kidney disease (ckd) on hemodialysis. however, to date there are no studies evaluating the effects of royal jelly on such complications in patients with rdc. objectives: to evaluate the effects of royal jelly on inflammation and cellular senescence in patients with ckd. methods: clinical, longitudinal, randomized study, with washout and crossover period. patients with ckd on hd received 140 ml bottles containing propolis and turmeric, and were instructed to take 10 ml/day (dosing cup), containing a dose equivalent to 110 mg/day of standardized green propolis extract (epp-af) plus 130 mg of curcuminoids/day or placebo for 8 weeks. after this supplementation, patients will enter the washout period (8 weeks) and after this period, the intervention group will receive placebo and vice versa. the collection of biological material (blood and feces) will be done before and after each study period. the mrna expression of the transcription factors nrf2 and nf-κb, as well as their target genes, antioxidant enzymes, inflammatory cytokines and the expression of genes and proteins that modulate the protein will be evaluated using rtpcr, western blotting and assay methods. multiplex. uremic toxins from the intestinal microbiota such as indoxyl sulfate (is), p-cresyl sulfate (p-cs) and indole-3-acetic acid (iaa) will be confirmed by hplc and plasma lipopolysaccharide (lps) levels will be analyzed by elisa. the determination of antioxidant capacity will be determined by the frap, orac and dpph methods. the analysis of the composition of the intestinal microbiota will be evaluated by high-throughput sequencing of the v4-v5 region of the 16s ribosomal rna gene. nutritional status and dietary intake will also be assessed.

Eligibility criteria:
inclusion criteria: * patients with ckd undergoing hemodialysis for more than 6 months * patients with arteriovenous fistula (avf) as vascular access. exclusion criteria: * pregnant, * lactating, * smoker * patients using antibiotics and antioxidant supplements in the last three months * patients with autoimmune and infectious diseases, * patients with cancer, liver disease, and aids

Keywords: cellular senescence renal dialysis renal insufficiency, chronic oxidative stress
autologous testicular tissue transplantation

Conditions: Cancer; Sickle Cell Thalassemia; Hematologic Diseases

Summary: freezing testicular tissue of prepubertal boys is a method for preserving spermatogonial stem cells (sscs) in case of imminent gonadotoxic treatment during childhood. in case of total azoospermia in adulthood and presence of a childwish, the investigators intend to perform the first in men autologous testicular tissue transplantation to restore fertility.

freezing testicular tissue of prepubertal boys is a method for preserving spermatogonial stem cells (sscs). in 2002, the university hospital in brussels (uzb) was the first hospital worldwide to offer testicular tissue cryobanking for fertility preservation in boys and ado-lescents. since then, several other centers in europe and usa have implemented similar fertility preservation programs. however, up till now, autologous transplantations of cryopreserved testicular tissue have not been performed yet. as soon as a patient returns to the centre for reproductive medicine at uzb with the request to transplant the preserved testicular tissue, the investigators will first analyse semen and blood. if spermatozoa are found in their semen, men can immediately enroll in standard care for natural conception, intra-uterine insemination (iui), in-vitro fertilization (ivf) or intra-cytoplasmic injection (icsi). however, in case no spermatozoa are found in the ejaculate the investigators intend to propose and eventually perform autologous testicular tissue transplantation with the primary objective being to restore spermatogenesis and fertility.

Eligibility criteria:
the eligible patients opted as a prepubertal boy to enroll in the fertility preservation program and on the moment of cancer diagnosis or hematological disorder, their parents have agreed to cryopreserve testicular tissue for later autologous transplantation. inclusion criteria: * at least 18 years old * desire to become a parent at the moment of intake * stable relationship with a female partner and minimal one year cohabiting * age of female partner \< 43 year * azoospermia on 2 semen analyses * normal standardised preliminary and preoperative bloodsampling results * complete remission of the oncological or hematological disease * approval of the treating oncologist or other specialist in case of non-oncological disease as reason for the testicular tissue preservation as a child * risk for presence of malignant cells in testicular tissue is negligible (according to multidisciplinary assessment) * presence of sscs (positive mage staining) in one or two of the thawed fragments (if absence of sscs in two of the thawed fragments, the case will be discussed multidisciplinary) * written informed consent for the transplantation of cryopreserved testicular tissue and follow-up after the procedure and of children born eventually after this procedure exclusion criteria: * risk for presence of malignant cells in the testicular tissue * contra-indication for surgery * contra-indication for pregnancy in the female partner * bmi \> 32 * heavy smoking (≥10 cigarettes/day) * instable psychological condition
nir fluorescence imaging technique in thoracic surgery with icg

Conditions: Lung Cancer; Esophageal Cancer

Summary: this study aims to first apply near-infrared fluorescence imaging technology in thoracic surgery with indocyanine green in china. to evaluate the feasibility usage of the investigators' fluorescence imaging systems and the safety applications in intraoperative sentinel lymph node mapping of lung and esophageal cancer, lung nodule imaging, lung segment resection boundary determination, esophagus - tubular anastomosis, thoracic duct imaging and chylothorax repairing thoracic surgery. aim to achieve precise boundaries definition during thoracic surgery and realize accurate, minimally invasive thoracic surgery with fluorescence imaging technology.

lung cancer is a major threat to human health. diagnosis and treatment using precision medicine is expected to be an effective method for preventing the initiation and progression of cancer. although anatomical and functional imaging techniques such as radiography, computed tomography (ct), magnetic resonance imaging (mri) and positron emission tomography (pet) have played an important role for accurate preoperative diagnostics, for the most part these techniques cannot be applied intraoperatively. optical molecular imaging is a promising technique that provides a high degree of sensitivity and specificity in tumor margin detection. furthermore, existing clinical applications have proven that optical molecular imaging is a powerful intraoperative tool for guiding surgeons performing precision procedures, thus enabling radical resection and improved survival rates. however, detection depth limitation exists in optical molecular imaging methods and further breakthroughs from optical open surgery to minimally invasive intraoperative imaging methods are needed to develop more extensive and comprehensive intraoperative applications.

Eligibility criteria:
inclusion criteria: * pulmonary nodules undergoing thoracoscopy or thoracotomy * esophageal cancer patients who underwent radical surgery * preoperative liver function is normal * no indocyanine green and iodine allergies, and indocyanine green skin test negative * volunteered to participate in this study and signed informed consent in this study exclusion criteria: * preoperative liver dysfunction * indocyanine green or iodine allergies, or indocyanine green skin test positive * not combined with other well-controlled comorbidities * clinicians considered unsuitable for enrollment

Keywords: thoracic duct sentinel lymph node biopsy
exploration of risk factors for postoperative cerebral infarction in lung cancer patients: a retrospective single-centre study

Conditions: Lung Cancer, Non-Small Cell; Postoperative Cerebral Infarction

Summary: lung cancer remains the world's leading cancer in terms of morbidity and mortality, with more than 20 million new cases and 9.7 million deaths annually. despite improvements in surgical techniques and medical care, the number of elderly people undergoing surgery is gradually increasing, so there are an increasing number of complications following lung resection. postoperative cerebral infarction is a relatively rare but devastating complication that places a heavy burden on patients and families. the incidence of postoperative cerebral infarction in patients after thoracic surgery has been reported to be 0.6-1.1%. there is a risk of postoperative cerebral infarction after lung cancer surgery, and the results of a few studies have shown that postoperative cerebral infarction is related to old age, male, hypertension, hyperlipidemia, and lobectomy factors, but the pathogenesis of the occurrence of cerebral infarction has not been clearly proved for the time being, and so these risk factors cannot be taken as the direct cause of cerebral infarction. therefore, we need to further explore the factors leading to cerebral infarction after lung cancer surgery. if we can further prove that some of the risk factors are related to the causes of cerebral infarction after lung cancer surgery, we can make corresponding strategies in the perioperative period to improve the safety of surgery and reduce the incidence of cerebral infarction in the postoperative period.


Eligibility criteria:
inclusion criteria: postoperative cerebral infarction exclusion criteria: no postoperative infarction
discontinuation for oral anticoagulants in patients with atrial fibrillation

Conditions: Auricular Fibrillation; Anticoagulant Drugs

Summary: the purpose of this study is to compare the discontinuation rates for vitamin k antagonists and for direct oral anticoagulants during their first year

the purpose of this study is to compare the discontinuation rates for vitamin k antagonists and for direct oral anticoagulants during their first year of use after their initiation during hospitalization in patients covered by our health insurance plan.

Eligibility criteria:
inclusion criteria: 1. patient older than 18 years of age covered by our health care insurance plan. 2. indication for oral anticoagulation with an expected duration of use of no less than 1 year. exclusion criteria: 1. refusal to take part. 2. use of oral anticoagulants within 6 months prior to admission. 3. presence of mechanical prosthetic valve. 4. chronic renal failure with creatinine clearance \<30 ml/min (estimated using the mdrd formula).
split-dose versus single-dose bowel preparation for colonoscopy

Conditions: Colonic Cancer; Colonic Polyp; IBS - Irritable Bowel Syndrome

Summary: colonoscopy is the current standard method for evaluation of colonic disorders such as colorectal cancer, ibd, polyps, and other conditions.

colonic cancers are a major concern in the middle east and the world in general, and every institute has attempted to initiate various clinical and investigatory procedures to detect the disease early in its development. from 2005 till 2010 an audit conducted at the royal liverpool university revealed that out of 8910 colonoscopies, 693 were incomplete (7.8%), and for 25% of failure was because of inadequate bowel preparation. an adequate bowel preparation regimen is not only effective in cleansing the colon but should be well tolerated by patients. the polyethylene glycol (peg) solution, an isosmotic non-absorbable polymer, is generally used for bowel preparation, because of its safety, effectiveness, and good tolerability. quality of bowel cleansing depends not only on the formula used, but the preparation regimen also plays a role. split dosing of the laxative offers, in general, better cleansing than a single dose preparation. a large survey was also done in the usa in 2018 and demonstrated that split dose treatment was more tolerable than single-dose treatment for bowel preparation. also more recent study shows split-dose bowel preparation for colonoscopy with peg is better than single-dose, in terms of adequate bowel preparation and polyp detection. on the other hand , a large randomized trial of peg regimens show, low-volume same-day resulted in similar bowel cleanliness compared with high-volume or low-volume split-dosing. willingness to repeat and tolerability were superior with low-volume same-day compared with high-volume split-dose and similar to low-volume split-dose. another most recent one demonstrated that same-day morning peg regimen can be considered an effective well-tolerated, and acceptable bowel preparation for colonoscopy. a same-day dose of bowel cleanser has several benefits compared with split-dose or previous-day dose: the fasting time is shorter and there is no sleep disturbance, which can be associated with split-dose or previous-day regimen.

Eligibility criteria:
inclusion criteria: - all patients undergoing elective colonoscopy exclusion criteria: * presence of sever renal impairment. (creatinine clearance \< 30 ml/min or patient on hemodialysis). * sever congestive heart failure (nhya iii or iv). * pregnant woman. * history of bowel obstruction or resection. * known allergies to polyethylene glycol. * refusal of consent for the study. * signs of liver cell failure as ascites and hepatic encephalopathy. * electrolytes disturbances
tranexamic acid in major orthopedic surgery: comparison of 3 dosage regimen

Conditions: Tranexamic Acid; Knee Osteoarthritis; Ankle Osteoarthritis; Bleeding

Summary: tranexamic acid has been shown to be effective in reducing blood loss and transfusion in orthopedic surgery. it remains unknown the ideal therapeutic regimen. the goal of this study is to compare 3 dosage regimen of tranexamic acid in patients submitted to major orthopedic surgery.

there is ongoing debate, however, around optimal perioperative tranexamic acid dosing, which varies widely. a large number of studies comparing tranexamic acid to placebo, overall blood loss and transfusion requirements are both reduced by ≈30%. a well designed tranexamic acid trial will provide answers to the best regimen dosage for perioperative tranexamic acid use. it will benefit patients by reducing allogeneic transfusions and their associated risks and costs, thus adding value to the care delivered.

Eligibility criteria:
inclusion criteria: * age ≥ 18 anos * total ankle arthroplasty * total knee arthroplasty * weight \>50 kilogram exclusion criteria: * allergy and hypersensitivity to tranexamic acid * thromboembolic events history * epilepsy * acute kidney injury, glomerular filtration rate \< 50 ml/min * coagulation disorders * surgical reintervention * blood transfusion refusal
study of probiotic potential of lactobacillus strains in the upper respiratory tract after nasal spray application

Conditions: Healthy Volunteers; Chronic Rhinosinusitis (Diagnosis); Probiotics; Sprays; Nasal Disease

Summary: probiotics are defined as "live micro-organisms that, when administered in adequate amounts, confer a health benefit to the host" (hill et al, 2014). these microbes are generally applied in the gastrointestinal tract via fermented food products or capsules. in previous research, the investigators isolated bacterial strains with potential probiotic properties for the upper respiratory tract based on in vitro laboratory tests, in vivo mice experiments and genome sequencing. in this study, the investigators want to deliver the proof-of-concept that the most promising isolated strain, lactobacillus casei ambr2 (lambr2) and the well-documented probiotic strain lactobacillus rhamnosus gg (lgg) also have interesting properties in humans, i.e. that these strains are able to -temporarily- persist in the upper respiratory tract of healthy volunteers and crs patients after daily nasal application via a nasal spray for 2 weeks. in addition, the investigators aim to explore whether the application of these strains has an impact on the nasopharyngeal microbiome via 16s rrna amplicon sequencing and dedicated qpcr analysis. therefore, bacterial dna from nasal swabs will be isolated via commercially available dna extraction kits, followed by illumina miseq sequencing in order to identify the bacterial species present in these samples. furthermore, the concentration of the lactobacillus and specific pathogens will be monitored via qpcr.


Eligibility criteria:
inclusion criteria: * crs patient group: crs diagnosed exclusion criteria: * no patients with trisomy 21 * no pregnant women * no breastfeeding women * no acute or chronic airway infections (except for crs patients in crs patient group) * no cancer * no autoimmune diseases
fr1da early diagnosis and care of type 1 diabetes

Conditions: Type 1 Diabetes Mellitus

Summary: the fr1da study: "early diagnosis and care of type 1 diabetes" aims to carry out a comprehensive, population-based screening for the early diagnosis of type 1 diabetes as part of the u7 to u11 preventive medical check-up for children or between the ages of 2 and 10 years in bavaria and to implement it in other federal states. screening is recommended at two time points: 1st screening at the age of 3 years (u7a) and 2nd screening at the age of 7 years (u10). in addition, relatives of patients with type 1 diabetes between the ages of 1 and 21 can be screened repeatedly at intervals of 3 to 5 years for an early-stage of type 1 diabetes.

with the fr1da study, 100,000 children in the free state of bavaria were offered a one-off screening for the early diagnosis of type 1 diabetes from january 1, 2015 to 2019 as part of the u7 (21st month of life) to u9 (64th month of life) check-ups, or as part of any other visit at the paediatrician between the ages of 2 and 5. after 100,000 children had been screened in the fr1da study, the screening was continued as part of fr1da (formerly fr1da-plus). the screening was then extended to a second age group from 6 to 10 years (u10-u11). as relatives of people with type 1 diabetes have an up to 10-fold increased risk of developing type 1 diabetes themselves, the screening is also offered to these people between the age 1 to 21 years. the aim of the fr1da study is 1) to prevent life-threatening ketoacidosis at clinical manifestation of type 1 diabetes, 2) to reduce anxiety, uncertainty and psychological stress through training and intensive support for those affected, 3) to test the feasibility of two-time nationwide screening and evaluate the benefits, 4) to determine the prevalence of early-stage type 1 diabetes in children in defined age groups and in first and second screening, 5) to identify geographical differences and associations with environmental factors in the development and progression of the disease and 6) to prevent disease progression by means of preventive therapies. from 2024, the screening will also be offered in other federal states outside of bavaria.

Eligibility criteria:
written informed consent by one custodial parent

Keywords: fr1da fr1da-plus type 1 diabetes islet autoantibodies