Kornimate/medical-research-clean huggingface dataset:
memory improvement with docosahexaenoic acid study (midas)

Conditions: Age-Related Cognitive Decline; Age-Related Memory Disorders

Summary: the purpose of this study is to investigate the effect of docosahexaenoic acid (dha, 22:6n-3) in improving cognitive functions in subjects with age-related cognitive decline. dha is a long chain omega-3 fatty acid (lc-pufa) that plays an important role in neural and visual development and cardiovascular health.


Eligibility criteria:
inclusion criteria: * males or females, aged 55 or greater. * have a subjective memory complaint and have a logical memory subtest (of the wechsler memory scale - iii \[wms-iii\]) raw score one standard deviation or greater below the mean of a younger population. * have the ability to understand the requirements of the study; be willing to provide written informed consent; and agree to abide by the study restrictions and return for the required assessments. * if taking non-prohibited medication, be on a stable drug regimen (in prior 3 months). exclusion criteria: * have a screening mini-mental state examination (mmse) \< 26. * consume greater than 200 mg/day dha as assessed on a dha food frequency questionnaire in the prior 2 months to screening. * use nutritional fish oil, flaxseed oil, omega-3 supplements, or huperzine in the prior 2 months to screening. * use acetylcholinesterase inhibitors or memantine in the prior 2 months to screening. * use major anti-psychotics or major anti-depressants. * use lipase inhibitors such as xenical® (orlistat). * history of major medical conditions including ischemic stroke, head trauma with loss of consciousness, epilepsy, psychosis, vascular dementia, depression (geriatric depression \[15-item\] \> 5), myocardial infarction (within 1 year), uncontrolled diabetes, or blindness. * history of major surgery within the past 6 months. * current use or history of drug and/or alcohol abuse within 5 years. * administration of any investigational product within the past 30 days. * inability to swallow capsules.

Keywords: cognition memory nutrition omega-3 dha
cisplatin and zd1839 + re-irradiation in recurrent squamous cell cancer of the head and neck

Conditions: Head and Neck Cancer; Carcinoma, Squamous Cell

Summary: to determine safety profile of the epidermal growth factor receptor (egfr) antagonist, zd1839 in combination with cisplatin and radiation therapy in patients with local-regional recurrent squamous cell cancer of the head and neck. to study the effects of zd1839 combined with either cisplatin or radiotherapy on signal transduction pathway gene expression in tumor cells in patients with local-regional recurrent squamous cell cancer of the head and neck using micro array analysis from tumor samples taken at the time of relapse and during treatment.


Eligibility criteria:
inclusion criteria:- patients must have pathologically confirmed recurrence (reappearance of previously cleared) squamous cell cancer primary in the upper aerodigestive tract or a second squamous cell primary (excluding nasopharynx or salivary gland tumors). patients may have experienced more than one recurrence as long as the first recurrence occurred greater than or equal to 6 months following the end of the prior rt. * the recurrence or second primary must have defined bi- or uni-dimensional measurements. * recurrence or second primary must be confined to the head and neck above the clavicles (loco-regional recurrence). * the patient must not be a candidate for complete surgical resection. the previous irradiation must not exceed a maximum of 75 gy. * the entire tumor volume must be included in a treatment field that limits the total spinal cord dose to 50 gy (prior rt and anticipated rt). * patients must be at least 6 months from prior radiation therapy. * patients may have received prior chemotherapy as a component of their primary treatment, but not for recurrent disease. * zubrod performance status 0-1. * granulocytes greater than or equal to 1500/mm3, platelets greater than or equal to 100,000/mm3, serum bilirubin less than or equal to 1.5 mg/dl, creatinine less than or equal to 1.5 mg/dl within 2 weeks prior to registration. * lft's less than or equal to 2 x normal (sgot/sgpt/alkaline phosphatase). if greater than 2 x normal, liver ultrasound or ct is required to exclude metastases. if negative for metastases, patients are eligible. * must be able to submit previous radiation records, including simulation and portal films, in order to assure that cord tolerance is not exceeded. * patients must sign a study-specific informed consent form prior to study entry. exclusion criteria:- primary in the nasopharynx or the salivary gland. * intercurrent medical illnesses which would impair patient tolerance to therapy or limit survival. * a history of allergic reactions attributed to compounds of similar chemical or biologic composition to zd1839 or other agents used in study. * pregnant and nursing women are excluded because of the potential teratogenic effects and potential unknown effects on nursing newborns.
study of biomarker from blood and tissue of head and neck carcinoma

Conditions: Laryngeal Neoplasms; Pharyngeal Neoplasms

Summary: the aim of the study is to find for one or more serum or tissue markers of molecular biology in head and neck cancer patients used for early diagnosis, predicting prognosis and being sensitive to chemotherapy and radiotherapy

head and neck malignant tumors, especially nasopharyngeal carcinoma in southern china with the high incidence, its incidence, treatment, prognosis or tumor markers in serum has been a hot research with little progress.in our study, we collect npc-based collection including the blood samples of laryngeal, hypopharyngeal cancer, separating serum and white blood cells stored in -80 degrees，while tissues are frozen in liquid nitrogen and embedded in paraffin。 patient treatment and prognosis are combined in order to find for markers of molecular biology used for early diagnosis, predicting prognosis and being sensitive to chemotherapy and radiotherapy.

Eligibility criteria:
inclusion criteria: * all of nasopharyngeal carcinoma * hypopharyngeal carcinoma or laryngeal carcinoma visited at ent department of nanfang hospital exclusion criteria: * all of above patients whose anticipated survival duration were less than 6 months

Keywords: laryngeal neoplasms pharyngeal neoplasms
decreased t1 times and impaired myocardial contractility in anabolic androgenic steroids users

Conditions: Focal Fibrosis

Summary: anabolic androgenic steroids (aas) abuse may have a toxic on myocardium that could lead to cardiac alterations. clinical cases reported myocardial fibrosis in aas users. however, recent studies did not find myocardial fibrosis in aas users using t1-mapping technique. the aim of this study was to evaluate cardiac structure by cardiovascular magnetic resonance (cmr) with late-gadolinium enhancement (lge), cardiac t1-mapping and extracellular volume (ecv). we also evaluated the cardiac contractility in aas users.

twenty strength-trained aas users (aasu) age 29±5 yr, 20 age-matched strength-trained aas nonusers (aasnu), and 10 sedentary controls (sc) were enrolled. cardiac structure was assessed by lge, t1-mapping and ecv. cardiac contractility was evaluated as cardiac strain by cmr (feature tracking) and echocardiography (speckle tracking)

Eligibility criteria:
inclusion criteria: * anabolic androgenic steroids users and anabolic androgenic steroids nonusers groups had been involved in strength training for at least 2 years; * anabolic androgenic steroids users should be self-administering anabolic androgenic steroids in periodic cycles lasting from 8 to 12 weeks for at least 2 years with 2-4 cycles per year; * all anabolic androgenic steroids users were on a cycle over the course of the study; * sedentary control group: sedentary men without cardiovascular disease. exclusion criteria: * smoking; * alcohol consumption; * use of diuretics and/or antihypertensive medications; * liver and kidney disease

Keywords: anabolic steroid t1-mapping cardiac structure
impact of trans fatty acids from natural and industrial origin in the induction of insulin resistance development

Conditions: Insulin Resistance; Obesity

Summary: the investigators' project has as for principal objective to understand the impact of trans fatty acids from dairy products and industrial origin on the development of insulin resistance in obese woman. because of the different isomeric position of the double bound those trans fatty acids may have different metabolic effects.

women will be included in the study according to their susceptibility to develop a insulin resistance (evaluated starting from the body index of mass imc superior to 28 kg.m-², of the waist measurement 88 cm). once included in the study, the volunteers will receive for 4 weeks butter, dairy products and biscuits enriched in stearic, elaidic or vaccenic acid. the volunteers will undergo a measurement of the body composition by biphotonic absorptiometry as well as a complete metabolic assessment (blood and urinary samples, clamp to insulin and biopsies).

Eligibility criteria:
inclusion criteria: * female * waist measurement \> 88 cm * body mass index\> 28kg/m2 * affiliated to national health insurance * subject giving his/her written informed consent * subject willing to comply with the study procedures * subject considered as normal after clinical examination and medical questionnaire exclusion criteria: * reported food allergies * currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study * hepatic or renal impairments * positive serologies to hiv or hcv, determined on blood sample * pregnant or presently attempting to get pregnant or menopause or lactating blood donation done less than 2 months before the start of the study * chronic pathologies: diabetes, hypertriglyceridemia, hypertension, cardiovascular diseases, chronic inflammatory diseases * intestine, cardiovascular, kidney and cancer pathologies in the last 5 years * previous heavy intestine surgery (except appendicectomy) * previous medical and/or surgery judged by the investigator as incompatible with this study * high variation (\> 5%) of body weight during the last 3 months * consuming nutritional supplements which could interfered with lipid metabolism (fish oil capsule, vitamins, soja lecithins,...) * heavy consumer of alcohol * smoker or ex-smoker who stopped smoking less than 1 month before v0 (more than 5 cigarettes/dy). * practising intensive physical exercise (\> 5 h per week) * vegetarian or vegan * being under someone's supervision * refusal to be registered on the national volunteers data file * disliking butter, margarine, cheese, biscuits and/or vegetable oil * dietary habits unreliable to controlled food intake * being in exclusion on the national volunteers data file

Keywords: trans fatty acid insulin resistance skeletal muscle adipose tissue
types of fixation of vancouver b1 periprosthetic fractures

Conditions: Femur Fractures

Summary: the purpose of this study is to compare two different but standard treatments for the fixation of vancouver b1 periprosthetic. the investigators aim to compare open reduction internal fixation using a locked plating system versus plating and strut allograft with cerclage wiring to determine which treatment results in a faster return to function as measured by the tug test at 6 weeks post-op.


Eligibility criteria:
inclusion criteria: * age: over 18, no upper limit * vancouver type b1 periprosthetic fracture * fracture is amenable to either treatment group * prosthesis is well fixed * provision of informed consent exclusion criteria: * presence of an active infection around the fracture (soft tissue or bone) * loose prosthesis * trauma patients with an iss \> 16 or associated major injuries of the lower extremities * known substance abuse * likely problems, in the judgment of the investigators, with maintaining follow-up (i.e., patients with no fixed address, report a plan to move out of town, or intellectually challenged patients without adequate family support)

Keywords: periprosthetic femur fractures vancouver b1
nivestim® (filgrastim) tolerance in patients treated by toxic chemotherapeutic agents

Conditions: Solid Tumors; Malignant Hemopathy; Chemotherapy-induced Febrile Neutropenia (FN)

Summary: the main aim of the study is to assess the safety of nivestim® treatment in patients treated with neutropenia-inducing chemotherapy for a malignant disease, solid tumor or a malignant hemopathy.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * patients presenting with a solid tumor or a malignant hemopathy, * patients treated with or beginning treatment with neutropenia-inducing chemotherapy (regardless of the cycle), * patients in whom treatment with nivestim® is instituted for the purpose of reducing the duration of the neutropenias and the incidence of the chemotherapy-induced febrile neutropenias exclusion criteria: * patients presenting with a chronic myeloproliferative syndrome, * patients presenting with a myelodysplastic syndrome, * patients showing hypersensitivity to any of the ingredients of nivestim®, * patients not receiving chemotherapy, * patients who were already included in the study during a previous chemotherapy line
prospective, multicenter hccis evaluation study

Conditions: Hepatocellular Carcinoma

Summary: with this prospective, multicenter trial the investigators aim to establish the hepatocellular immune score (hccis), a score that has been developed in a retrospective study, as a new tool for risk stratification of patients after resection of hepatocellular carcinoma that can be widely used in the clinical practice. the investigators expect to show that this score is a prognosticator for overall survival and also disease free survival. further, it should be demonstrated that the hccis is a risk stratification tool that is independent from clinical or descriptive parameters. additionally, the investigators plan to elucidate that the respective hccis risk groups are not only different with respect to immunological infiltration but are also different with respect to tumor biology. the finding, that tumors of the respective risk groups show different tumor biology leads to the assumption that different therapy strategies need to be applied. therefore, in a translational approach we aim to build up a data base with hcc tumor organoids and test the effect of cd8+il-33+ effector-memory cells on hcc tumor organoids of the respective hccis risk groups.


Eligibility criteria:
inclusion criteria: * patients \>18 years old who are receiving primary liver resection in curative intent for hcc after informed consent is obtained. exclusion criteria: * patients who have not given informed consent or who have withdrawn their consent will be excluded from this analysis. in case there is not enough liver tissue for a histological analysis or the remaining liver tissue is not enough to perform a routine pathological analysis patients have to be excluded from the further analysis. in case of an r1 or r2 resection, patients have to be excluded from further analysis. however, these patients will remain in the study as an intention to treat analysis.
utility of remote lung auscultation in transitions of care after pulmonary exacerbations of copd

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: listening to breath sounds with the stethoscope/auscultation is used by pulmonary physicians in conjunction with pulmonary function, signs and symptoms, oxygen saturation and diagnostic testing to admit, follow and discharge patients from hospital. of these, only auscultation routinely ceases upon discharge from hospital. healthcare utilization statistics have shown that for more than a decade, readmission after discharge for an exacerbation of copd or severe asthma (or chronic heart failure) remains a major problem. the strados resp biosensor has been designed to extend the range of lung sound recording both geographically and temporally to improve the standard of care when access to continuous monitoring has been replaced by periodic or no monitoring. the primary purpose of this study is to assess the associations between resp biosensor-acquired lung findings and subjective measures of respiratory symptoms as measured by validated measurement tools, and objective measure of respiratory physiology as determined by home spirometry


Eligibility criteria:
inclusion criteria: 1. males and females between the ages of 35 and 75 with documented physician-diagnosed copd 2. hospitalization with a primary diagnosis of copd with exacerbation or pneumonia. 3. patient able and willing to provide informed consent. 4. patient can follow study procedures, including instructions for self-placement and operation of device a. patient has experience using a smartphone 5. accessible by telehealth/telephone upon discharge 6. patient is able and willing to return to study site for study follow-up visits as necessary exclusion criteria: 1. patient unable or unwilling to provide informed consent 2. diagnosis of copd is uncertain 3. plan for discharge to location other than the patient's home (eg, nursing home, rehabilitation facility) 4. patient with end-stage medical condition with expected survival no more than 3 months 5. history of adverse reaction or allergy to tegaderm® 6. inaccessible by telehealth/telephone post discharge
management of sleeve gastrectomy failure using single-anastomosis metabolic surgery

Conditions: Obesity; Obesity, Morbid

Summary: sleeve gastrectomy (sg) has become the most commonly performed weight loss surgery, accounting for 60% of all bariatric operations worldwide. while technically easier with less side-effects and nutritional risks than other operations, sg is also associated with a higher risk of failure (20 to 40%). in such case, the most effective option consists in adding an intestinal bypass called the biliopancreatic diversion with duodenal switch (bpd-ds). this surgery is, however, technically challenging and yields a significant risk of complications, nutritional deficiencies or gastro-intestinal side-effects. recently, a simplified version of the standard ds, called single-anastomosis duodenoileal switch (sadi-s) was endorsed by surgical societies as one of the approved bariatric procedures. there is currently no prospective or randomized data to support the effectiveness of this new procedure, especially as a revisional approach. the overall objective of this randomized controlled trial project is to establish the clinical benefits of the sadi-s as a revisional surgery after sg, while also considering critical issues related to sex and gender. the investigator overall hypothesis is that the sadi-s represents a relevant revisional option for weight loss and metabolic recovery in women and men suffering from severe obesity who had a previous sg. the investigator propose to address the following research question. research question: what are the clinical effects of sadi-s compared to standard ds when used as a revisional procedure after sg, in patients with obesity? participants who need revisional surgery after sg will be enrolled in a prospective, randomized, double-blind (patient-evaluator), non-inferiority trial comparing sadi-s vs ds. the primary outcome will be 12-month excess weight loss. secondary outcomes will be perioperative complications, risk of malnutrition, quality of life and gastrointestinal side effects. the investigator hypothesize that sadi-s offers similar weight loss compared to standard ds, but a lower risk of complications and nutritional deficiencies. with the increase in the number of bariatric operations performed worldwide and the recent endorsement of the sadi-s as a regular procedure, reliable clinical data are urgently needed. the present proposal will directly address this knowledge gap.


Eligibility criteria:
inclusion criteria: * had sleeve gastrectomy a minimum of 18 months before * still meet the nih criteria for bariatric surgery (bmi≥35kg/m2 with major comorbidities or bmi≥40kg/m2) or patients with ewl\<50% or significant weight regain (≥20%ewl) exclusion criteria: * general contra-indication for bariatric surgery * bmi\<35kg/m2 * pregnancy * cirrhosis * abnormal bowel habits including irritable bowel syndrome and inflammatory bowel disease

Keywords: bariatric surgery
new, easy and efficient ways to classify acetabular fractures

Conditions: Acetabular Fracture

Summary: acetabular fractures are the resultant from high-energy trauma or low-energy trauma in the elder patients. usually, surgeons use letournel's classification or/and judet's one. five elements are considered and associated to five type of fracture. even more, for orthopaedic surgeons with less experience with these fractures, correct classification can be more difficult. so the the aim of this study is: 1. evaluate the efficacy of four "special" 3d reconstruction: a 3d reconstruction of the pelvis with anterior view, posterior view, endopelvic view where the opposite hemipelvis removed and an exopelvic view where the femoral head is removed according to the initial teaching of e. letournel. 2. evaluate the addition of teaching of non-experimented surgeon on the accuracy of classifying acetabular fractures. 3. evaluate the addition of a digital algorithm (mobile application) on the accuracy of classifying acetabular fractures.

12 reviewers will be given the different imaging of each case and will be divided in 4 groups: novice (junior er and ortho residents), intermediate (non-experimented orthopedic surgeons), intermediate with a formation on classifying acetabular fractures and finally experts (acetabular fracture expert surgeons) . for each patient, representative ct scans are provided for each assessment. the study will be divided into 3 phases separated by 4-6 weeks of time. in the first phase, for each patient, representative ct scans are provided for each assessment with 2d and multiplanar reconstruction (mpr) without 3d views. in the second phase, 3d views are added. in the third phase, the cases are evaluated using the "acetabular diagnosis tool" to note, the evaluation of the cases is done twice in each phase separated by 4-6 weeks and the order of the cases is changed, both in order to minimize recall bias

Eligibility criteria:
inclusion criteria: * acetabular fracture exclusion criteria: * no criteria
upper extremity paın and ultrasound use

Conditions: Pain, Chronic; Upper Extremity Problem

Summary: the relationship between perinatologists' ultrasound use and upper limb joint pain will be evaluated.


Eligibility criteria:
inclusion criteria: * those who have received specialization training in the branch of perinatology and have completed their specialty in the branch and worked as a perinatologist * those who want to participate in the study exclusion criteria: * patients with discomfort and operation in the upper limb prior to perinatology training * physicians in other branches