Kornimate/medical-research-clean huggingface dataset:
a registered observational cohort study of myotonic dystrophy type 1

Conditions: Myotonic Dystrophy Type 1 (DM1)

Summary: myotonic dystrophy type 1 (dm1) is the most common form of muscular dystrophy.there is little phenotype and genetic data for chinese dm1 patients. the data to be collected is intended to fill this gap and provide complementary data

myotonic dystrophy 1 (dm1) is an autosomal, dominantly inherited neuromuscular disorder characterized by skeletal muscle weakness, myotonia, cardiac conduction abnormalities, cataracts, and other abnormalities. the china dm1 patient registry is a nationwide, population-based, non-interventional, observational cohort clinical study of all age groups of genetically-confirmed dm1 patients from families (with at least 1 affected member), collecting data retrospectively at study entry and prospectively during follow up. currently, there is limited phenotype and genotype data available for dm1 patients with chinese han ethnicity. therefore, the data to be collected is intended to fill this gap and provide complementary data.

Eligibility criteria:
inclusion criteria: * male or female subjects of all ages at baseline * subjects, with or without symptoms, with dm1 genetic confirmation through triplet-primed pcr or long-read sequencing * unrelated healthy controls exclusion criteria: * decline to participate * other neuromuscular disease (such as limb-girdle muscular dystrophy or oculopharyngodistal myopathy) * serious systemic illness (such as heart, liver, kidney disease or major mental illness)

Keywords: myotonic dystrophy type 1 tandem repeat
calm-ad

Conditions: Alzheimer's Disease

Summary: primary aim to determine whether; * donepezil is significantly better than placebo in the management of agitation in alzheimer's disease that has not responded to, or is inappropriate for a standardised brief psychosocial treatment secondary aims to determine whether; * donepezil has a significant positive or negative impact upon quality of life compared with placebo * whether there is a significant difference between donepezil and placebo with respect to cognitive performance * the cost effectiveness of the pharmacological treatment for agitation


Eligibility criteria:
inclusion criteria: a diagnosis of dementia consistent with diagnostic and statistical manual of mental health disorders, revised 3rd edition (dsm-iii-r) (apa, 1987) national institute of neurological and communicative disorders and stroke - alzheimer's disease and related disorders association (nincds-adrda) diagnostic criteria for probably or possible ad (mkhann et al, 1984) (appendix 6) clinically significant agitation (defined as causing distress to patient and at least moderate management problems for carers on at least two days per week for a two week period, together with a cohen mansfield agitation inventory (cmai) (cohen-mansfield, 1986) (appendix 11 a) score \>39 age \>39 years resident in care facility or community living with a carer not receiving treatment with neuroleptics or cholinesterase inhibitors currently or in the past four weeks and responsible clinician not considering treatment with cholinesterase inhibitor for the next 16 weeks taking into account the clinical evidence base and nice guideline (nice, 2001) patient with capacity willing to consent to study or will to participate in study if lacking capacity carer with capacity willing to consent to study and in agreement for patient lacking capacity to participate if patient willing to participate - exclusion criteria:known sensitivity to donepezil severe, unstable or uncontrolled medical conditions apparent from history, physical examination or investigations current evidence of delirium patient meets criteria for probably dementia with lewy bodies (mckeith et al, 1996) low probability of treatment compliance -

Keywords: dementia
activity changes in irritable bowel syndrome (ibs), anxiety, and depression following the use of viome precision nutrition program (vpnp)

Conditions: Depression, Anxiety; IBS - Irritable Bowel Syndrome

Summary: viome costumers are consented and recruited for this study and complete the questionnaires upon enrollment. any participant who previously self reported depression, anxiety, or irritable bowel syndrome (ibs) qualify for this study. all participants receive viome's diet, supplement and recommendations.

participants receive viome precision nutrition program (vpnp) after completing the health assessment and questionnaire. vpnp consists of diet, supplement and recommendations based on results from their sample results and their self reported questionnaire. after approximately 5 months, participants were given the same health assessment questionnaire. the results and data collected before and after the vpnp are analyzed to find correlations and differences between the measurements taken at the beginning of the trial and again approximately 5 months after.

Eligibility criteria:
inclusion criteria: * phq-9 score 5 or above * gad-7 score 5 or above * ibs rome-iv score 125 or above * females and males aged 18 years or older * signed and dated informed consent prior to any trial-specific procedures are performed * able to speak and read english * willing and able to follow the trial instructions * viome existing costumer exclusion criteria: * unable/unwilling to complete the provided questionnaires

Keywords: depression anxiety irritable bowel syndrome viome precision nutrition program vnpn ibs phq9 gad7 rome-iv viome diet nutrition supplements
a twenty-years' experience in pituitary disease.

Conditions: Pituitary Adenoma; Pituitary Cancer; Pituitary Disease

Summary: pituitary tumors represent a heterogeneous group of neoplasms by histotype. the pituitary adenomas are the most frequent heteroformation, among those affecting the pituitary gland, followed by meningiomas, craniopharyngiomas, germosomes and tumours secondary, such as metastases and lymphomas. since these conditions are considered rare, the data epidemiology and prognosis to predict the natural history of these diseases can not be considered conclusive. pituitary adenomas are a useful model for epidemiology in the study of pathology pituitary. over the past 20 years, several attempts have been made to identify unique prognostic factors, which predict the outcome of these pathologies, but without to arrive at a definitive classification. the purpose of this study aims to collect clinical, biochemical, morphological and pathological data on the retrospective and prospective cohort of over 1600 patients undergoing neurosurgical removal of pituitary tumors in the last 20 years, to develop a prognostic classification.


Eligibility criteria:
inclusion criteria: * patients underwent surgery for pituitary tumors; * pathology diagnosis of pituitary tumors; * patients older then 18 years at diagnosis of pituitary tumors; * 2 years follow-up; exclusion criteria: * age lower then 18 years * follow-up shorter than 2 years
does administration of etomidate and propofol of the anesthetic induction of elderly hypertensive patient provide superior blood pressure stability in response to direct laryngoscopy when compared to propofol or etomidate alone?

Conditions: Hypertension

Summary: this study will attempt to show that a combination of drugs, etomidate and propofol, provide a more stable blood pressure when used to put elderly hypertensive patients to sleep than either drug used alone.

same as above.

Eligibility criteria:
inclusion criteria: * patients at least 65 years old, with a history of hypertension. exclusion criteria: * patients less than 65 years old or without a history of hypertension.

Keywords: elderly hypertensive anesthesia
whole body magnetic resonance angiography with subsystolic venous compression

Conditions: Atherosclerosis; Intermittent Claudication

Summary: to investigate the diagnostic performance of whole body magnetic resonance angiography (wb-mra) using subsystolic venous compression of the thigh.

wb-mra is an examination that can evaluate the arteries from head to feet. timing of the injected bolus of contrast medium can be difficult, especially in the legs. as the result of the wb-mra depends on the contrast medium only being in the arteries at the time of examination, the use of venous compression is a possible way of overcoming the problem of early venous filling, that can hamper the diagnostic value of the examination. venous compression is performed with a blod pressure cuff around the thighs. it is inflated to subsystolic pressure (45 mm hg). this elevated pressure leads to filling of the lower leg arteries and late venous filling.

Eligibility criteria:
inclusion criteria: * symptomatic lower extremity ischemia (claudication, ischemic wounds) * referred to digital subtraction angiography (dsa) exclusion criteria: * renal insufficiency (gfr \< 30 ml/min) * contra-indications for mri-examination (claustrophobia, metal-implants, pacemaker) * dementia * pregnancy/lactation * allergy to gadolinium based mri contrast agents * acute disease

Keywords: magnetic resonance whole body angiography venous compression mri
using artificial intelligence-based chatbot to improve women's participation to cervical cancer screening programme

Conditions: Cervical Cancer Screening; Cervical Cancer

Summary: this project looks to improve the return rate of hpv self-sampling (hpvss) as well as the management of women hpvss positive.

france has already implemented a cervical screening programme based on hpv test for the whole female population aged 30-65 years. non-participant women can perform hpv test at their home. however, less than 20% of french women performed vaginal self-sampling when a kit was sent to their home. women with lower income and educational levels participate less to cervical screening. a variety of personal, practitioner, test-related and logistical barriers negatively impact the screening participation of french women. key barriers to participation could be addressed by overcoming disparities in hpv-related knowledge and perceptions about cervical cancer screening. this study aims to evaluate the impact of sending hpv self-sampling kit at women's home, associated with providing, through multiple mobile channels, a multi-language decision aid designed for women with lower education accessible via artificial intelligence-based chatbot. this decision aid will help women review high quality evidence on cervical cancer disease and screening modalities.

Eligibility criteria:
inclusion criteria: eligible women will be: * aged 30-65 * did not perform a pap smear in the last 4 years * are living in deprived clusters in the occitanie region. * did not answer to a first "invitation" letter to perform a clinician-collected hpv testing exclusion criteria: ineligible women will be those: * outside the target age group * had a pap smear in the past 3 years * had hysterectomy including cervix * are pregnant beyond 6 months * already scheduled a screening appointment or had just attended a hpv screening * had a cervical abnormality that was under exploration and/or treatment. * participated to the study pilot

Keywords: cervical neoplasia cervical cancer screening chatbot artificial intelligence cluster randomized controlled trial hpv vaginal self-sampling
effect of suicide prevention training for professionals

Conditions: Knowledge, Attitudes, Practice

Summary: annually a substantial number of courses and trainings are organised in flanders with regard to suicide prevention.these trainings are mainly aimed at intermediaries, such as caregivers, teachers, police, etc. from previous research it appears that such trainings are one of the most effective strategies for increasing knowledge, attitudes, skills and self-confidence with regard to dealing with persons who are suicidal and with crisis situations. however, such research has not yet been conducted in flanders, which means that the effect of the training on the knowledge and attitudes of the intermediaries could not yet be determined. therefore, this study aims to determine the effect of the trainings in flanders. these trainings are organised by the centre for the prevention of suicide (cpz) and by the suicide prevention workers of the centers for mental health care. all participants who register for one of these trainings will be invited by e-mail at three moments to complete an online questionnaire: * pre-test: one week before the training, * post-test: after the training, * follow-up: three months after training.


Eligibility criteria:
inclusion criteria: * participating in a suicide prevention training organised by 'centrum ter preventie van zelfdoding' or 'suïcidepreventiewerking centra geestelijke gezondheidszorg' exclusion criteria: * not participating in a suicide prevention training organised by 'centrum ter preventie van zelfdoding' or 'suïcidepreventiewerking centra geestelijke gezondheidszorg'
efficacy of stem cell transplantation compared to rehabilitation treatment of patients with cerebral paralysis

Conditions: Cerebral Palsy

Summary: cerebral palsy (cp) is described as a group of permanent disorders affecting motor development and posture, resulting in activity limitation attributed to nonprogressive disturbances of the fetal or infant brain. the prevalence of cerebral palsy has increased among the children with low birth-weight, jaundice, respiratory distress and intrauterine infection and so on. the incidence of cerebral palsy is increasing gradually with increased neonatal survival rate. although there are many kinds of functional therapy programs especially the rehabilitation treatment for cerebral palsy, their effects are limited. increasing cerebral palsy patients become a heavy burden to the family and society. stem cell based therapy, a new prospective therapy for central nervous system disorders, has the potential to repair the damaged brain tissue in patients with cerebral palsy. in this study, 300 patients with cerebral palsy will be divided into three groups and the investigators will use mesenchymal stem cells derived from umbilical cord to treat 100 cp patients of them randomly. we will also follow up the other 100 patients who only receive rehabilitation treatment and another 100 patients who accept neither stem cell therapy nor rehabilitation treatment. on this basis, as the investigators we can compare the efficacy of cell therapy and rehabilitation treatments for cerebral palsy patients. multiple sources of assessment were used to ascertain and classify all cases of cerebral palsy. particularly the gross motor function measure (gmfm) as an important valid and reliable outcome measure, has made it possible to evaluate the severity of movement disability，change over time and the effects of clinical interventions. it also will be the primary outcome measure in follow-up analysis of this study.

patients enrolled in this study need to finish our whole follow-up survey for 12 months, which is carried out by clinical doctors, rehabilitators and epidemiologist.

Eligibility criteria:
inclusion criteria: * patients with diagnosis of cerebral palsy. * patients' curator must be able to give voluntary consent. exclusion criteria: * intracranial infection. * severe respiratory and circulatory system diseases. * hematologic malignancies. * positive serological tests such as aids, hepatitis b virus, hepatitis c virus and syphilis （antigen or antibody）. * tumors. * genetic and metabolic diseases.

Keywords: cerebral palsy cell transplantation rehabilitation
evaluation of safety and efficacy of using seraffix ltb - system for excisional biopsy wounds closure

Conditions: Dehiscence, Surgical Wound

Summary: the purpose of this study is to evaluate the safety and effectiveness of using seraffix ltb system for excisional biopsy wounds closure

excisional biopsy of the skin is a biopsy in which an entire lesion is removed. an excisional biopsy is in contrast to an incisional biopsy in which only a sample of tissue is cut into and removed. it is most frequently done to diagnose a skin growth such as a mole, or cancer of the skin. the most common method of wound closure of skin excisions is interrupted nonabsorbable sutures. the sutures should be removed as soon as adequate intrinsic bonding strength is sufficient, depending mostly on the specific body region (from 5-7 days for the face and up to 12-14 days for trunk and extremities). laser energy, also known as laser welding, has been used on limited basis as an alternative to traditional wound closure method. there have been two fundamental approaches to laser assisted bonding of tissues: 1. laser welding-heating the approximated edges of cuts in tissues by a laser beam; 2. laser soldering- applying a biological solder onto the approximated edges and heating the solder (and the underlying tissue). seraffix has developed the seraffix ltb (laser tissue bonding) system - a laser system for soft tissue bonding. this innovative system includes features that make laser soldering suitable for clinical use. the seraffix system is composed of co2 laser device, propriety grip device (clamps) and soldering agent (human albumin).

Eligibility criteria:
inclusion criteria: 1. male/female age 18-60. 2. subject is scheduled for excisional biopsy surgery. 3. subject able to comprehend and give informed consent for participation in this study. 4. signed informed consent form. exclusion criteria: 1. unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months prior to screening. 2. acute infection requiring intravenous antibiotics at the time of screening. 3. bleeding, coagulation and or clotting disorders. 4. diabetes mellitus: iddm or niddm. 5. hiv positive or any other immunosuppressive disorder. 6. renal failure (serum creatinine \>2.0 mg/dl). 7. inflammatory and or allergic diseases or condition of the skin: psoriasis, eczema or dermatitis. 8. any concomitant infection - viral or bacterial. 9. drug abuse. 10. use of steroids. 11. infection / abscess / pain in treatment target area. 12. pregnancy or lactating. 13. history of keloid scarring. 14. use of aspirin or antioxidants 15. subject is suffering extreme general weakness. 16. subject objects to the study protocol. 17. known cognitive or psychiatric disorder 18. concurrent participation in any other clinical study. 19. physician objection.

Keywords: laser bonding soft tissue albumin
study evaluating microbiological analysis of spontaneous draining acute otitis media

Conditions: Otitis Media

Summary: describe the patient population and bacterial microbiology of pediatric patients presenting with spontaneous draining acute otitis media


Eligibility criteria:
inclusion criteria: main inclusion criteria: * children \>= 2 months and =\< 5 years * spontaneous draining aom =\< 2 days main exclusion criteria: exclusion criteria: * previous operation of the ear * chronic otitis media or tube placement with drainage \>= 3 days * chronic disease/immune deficiency

Keywords: acute otitis media serotype distribution
gonoscreen: efficacy of screening stis in msm

Conditions: Neisseria Gonorrhoeae Infection; Chlamydia Trachomatis Infection

Summary: a multicentre, controlled, randomized trial of 3 site (urethra, pharynx and rectum) sampling performed every 3 months (3x3) for neisseria gonorrhoea (ng)/chlamydia trachomatis (ct) screening (comparator) vs. no screening (intervention).

this study is a multicentre, controlled, randomized trial of 3x3 ng/ct screening (comparator) vs. no screening (intervention). it will be performed in the prep cohorts situated at the institute of tropical medicine (itm), hôpital saint-pierre (hsp), liège university hospital (chu), university hospital of gent (uzg) and erasmus hospital (eh). all men in follow up at these five centres who report having had sex with another man in the previous year and are enrolled for prep follow up will be eligible to participate in the study. after signing informed consent participants will be randomized via a computer-generated schema to either 3x3 screening or no ng/ct screening. in both arms, participants will be followed up in an identical fashion including 3x3 screening. the only difference between the arms will be that in the screening arm, ng/ct results will be sent by the sti laboratory to the study physicians and these participants will be treated and partner contact tracing will be done. the sexually transmitted infection (sti) laboratory will only process the samples/report the results from the non-screening arm at the end of the study. in both arms, all individuals with symptoms compatible with ng or ct will be tested and treated for these infections according to current best practice guidelines. at the end of the 12-month study period, participants whose most recent tests were positive for ng or ct will receive treatment for these.

Eligibility criteria:
inclusion criteria: * able and willing to provide informed consent * men (born as males) and transwomen aged 18 or more * has had sex\*\* with another man in the last 12 months * enrolled in belgian prep program at itm/hsp/eh/chu/uzg with approval for tdf/ftc (tenofovir disoproxil fumarate/emtricitabine) reimbursement from a belgian medical aid * willing to comply with the study procedures and to attend the clinic for the 3-monthly visits exclusion criteria: * enrolment in another interventional trial * tests hiv-positive at screening * symptoms of proctitis or urethritis

Keywords: screening
comparison of blood pressure medications on metabolism

Conditions: Diabetes

Summary: the purpose of this study is to determine if there are differences, (benefits) between carvedilol and metoprolol in the treatment of htn in patients with type 2 diabetes. specifically we will be looking at differences in blood pressure and blood sugar control, endothelial function, inflammation, oxidative stress and coagulation. subjects will be randomized to one of the two beta-blockers and followed for 5 months. each subject will undergo 4 inpatient studies where an oral glucose tolerance test will be done, inflammatory and oxidative stress markers will be measured. endothelial function will be measured using brachial artery ultrasound and laser skin doppler

the purpose of this study is to determine if there are differences, (benefits) between carvedilol and metoprolol in the treatment of htn in patients with type 2 diabetes. specifically we will be looking at differences in blood pressure and blood sugar control, endothelial function, inflammation, oxidative stress and coagulation. subjects will be randomized to one of the two beta-blockers and followed for 5 months. each subject will undergo 4 inpatient studies where an oral glucose tolerance test will be done, inflammatory and oxidative stress markers will be measured. endothelial function will be measured using brachial artery ultrasound and laser skin doppler. baseline visit will be done when subjects are off all antihypertension medications except acei/arb. following the baseline study subjects will be randomized to study drug. the dose will be titrated until goal blood pressure is reached. add on medication will be used if needed. subjects will then undergo a second study. the third study will take place after 5 months on treatment. stud drug will then be stoppped and subjects will be restudied 2 weeks later

Eligibility criteria:
inclusion criteria: * not enrolling exclusion criteria: * not enrolling

Keywords: diabetes blood pressure oxidative stress